Document ID: EPA-HQ-OPP-2011-0394-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2012-08-17T04:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

Office of Chemical Safety and Pollution Prevention

MEMORANDUM			

May 3, 2012								

SUBJECT:	Cyprodinil – Acute and Chronic Dietary and Drinking Water
Exposure and Risk Assessment.  

PC Code:  288202	DP Barcode: D390233 & 398362

Decision No.:  447576 & 448809	Registration No.: 100-953

Petition No.:  1E7854 & 1E7869	Regulatory Action:  Section 3 

Risk Assessment Type:  Dietary	Case No.:  NA

TXR No.:  NA	CAS No: 121552-61-2

MRID No.:  NA	40 CFR:  180.532

FROM:	Thurston G. Morton, Chemist

Risk Assessment Branch IV

Health Effects Division (7509P)

THROUGH:	Doug Dotson, Chemist 

		Meheret Negussie, Chemist

		Dietary Exposure Science Advisory Council (DESAC),

		and

		Susan Hummel, Senior Scientist, RAB IV

		Elissa Reaves, PhD. Branch Chief

Health Effects Division (7509P)

TO:		Rebecca Daiss, Risk Assessor, RAB IV

Health Effects Division (7509P)

					and

				Lisa Jones/Erik Kraft, RM20

				Fungicide Branch

Registration Division (7505P)

This document provides an acute and chronic dietary and drinking water
risk analyses of exposures resulting from use of cyprodinil as a
fungicide on food crops.  This assessment supports requests to amend the
use of cyprodinil on a number of expanded crop groups, add the remaining
fruiting vegetables (in addition to tomato), and to add the new use on
leafy petioles subgroup 4B.  Grapes are being expanded to crop subgroup
13-07F and strawberry to 13-07G.

Executive Summary

Acute and chronic dietary risk assessments were conducted for cyprodinil
using the Dietary Exposure Evaluation Model (DEEM-FCID™, Version
2.03), which uses food consumption data from the USDA’s Continuing
Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998. 

   

Acute Dietary Exposure Analysis Results and Characterization

A conservative acute dietary exposure analysis was performed for the
general U.S. population and various population subgroups.  Tolerance
level residues and 100 % crop treated assumptions were used.  DEEM
default and empirical processing factors were used to modify the
tolerance values.  The acute analysis incorporated the 1 in 10 year peak
surface drinking water estimate from application of cyprodinil to
grapes.    SEQ CHAPTER \h \r 1 The resulting 95th percentile acute
exposure estimates are not of concern for the general U.S. population or
any of the other population subgroups.  The subgroup with the highest
risk estimate is children 1-2 years old with a % acute population
adjusted dose (aPAD) of 8%.  The% aPAD for the general U.S. population
is 5%.     

Chronic Dietary Exposure Analysis Results and Characterization

A moderately refined chronic dietary exposure analysis was performed for
the general U.S. population and various population subgroups.  For the
chronic dietary analysis, tolerance level residues for most commodities;
average field trial residues for pome fruit, head lettuce, leaf lettuce,
and grapes; and 100% crop treated assumptions were used.  DEEM default
and empirical processing factors were used to modify the tolerance
values.  The chronic analysis incorporated the 10 year average surface
drinking water estimate from application of cyprodinil to grapes. 
Chronic dietary risk estimates are not of concern for the general U.S.
population or any of the other population subgroups.  The subgroup with
the highest risk estimate is children 1-2 years old with a % chronic PAD
(cPAD) of 75%.  The% cPAD for the general U.S. population is 28%. 

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the PAD.  The PAD is equivalent
to the point of departure (POD, NOAEL, LOAEL, etc) divided by the
required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  References that discuss
the acute and chronic risk assessments in more detail are available on
the EPA/pesticides web site:  “Available Information on Assessing
Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link:   
HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA_PEST/2000/July/Day_12/6061.pdf  ; or see
SOP 99.6 (8/20/99).

II.	Residue Information

Residues of Concern 

The metabolism of cyprodinil has been studied in apple, peach, potato,
tomato, and wheat.  The residue of concern in plants is the parent
compound cyprodinil as determined by the HED Metabolism Assessment
Review Committee (MARC) (D243198, G. Kramer, 3/11/98).  The nature of
the residue in ruminants is adequately understood based on acceptable
lactating goat metabolism studies.  HED has concluded that the residues
of concern for both risk assessment and the tolerance definition should
include the combined residues of cyprodinil and free and conjugated
CGA-304075, expressed in parent equivalents (D345970 and D345182, G.
Kramer, 6/4/08).  The water residues of concern as determined by MARC
are the parent and CGA 249287 (4-cyclopropyl-6-methylpyrimidin-2-amine)
(D292557, 6/8/03).  HED continues to consider these metabolites and
degradates to be the residues of concern.

Table 1:  Summary of Residues of Concern for Cyprodinil 

Matrix	Residues of Concern

	For Risk Assessment	For Tolerance Expression

Plants	cyprodinil	cyprodinil

Livestock	cyprodinil and CGA-304075	cyprodinil and CGA-304075

Water	cyprodinil and CGA 249287	cyprodinil

Established/Recommended Tolerances

Permanent tolerances are established (40 CFR §180.532(a)) for residues
of cyprodinil per se in/on a variety of crop commodities, at levels
ranging from 0.02 ppm in/on almonds to 340 ppm in citrus oil. 
Recommended tolerances for the proposed amended/new uses are as follows
(D389554, T. Morton, 05/3//2012).  

Onion, bulb, subgroup 3-07A…..	0.6 ppm

Onion, green, subgroup 3-07B	4.0 ppm

Caneberry  subgroup
13-07A……………………………………………….10 ppm

Bushberry subgroup 13-07B	………3.0 ppm

Fruit, small vine climbing, except fuzzy kiwifruit, subgroup 13-07F,
……..2.0 ppm

Berry, low growing subgroup 13-07G, except cranberry	5.0 ppm

Dragon fruit 	2.0 ppm

Fruit, pome, group 11-10	1.7 ppm

Vegetable, fruiting, group 8-10	1.5 ppm

Vegetable, leafy, except brassica, subgroup
4A……………........................	50 ppm

Leafy petiole subgroup 04B	30 ppm

Citrus,
oil……………………………………………………………
……….60 ppm

HED continues to recommend that the current tolerance expression for
animal commodities be changed to reflect both parent and metabolite
CGA-304075 (4-[(4-cyclopropyl-6-methyl-2-2-pyrimidinyl)amino]-phenol).

Residues Used in the Acute and Chronic Analysis

For the acute dietary analysis, tolerance level residues and 100% crop
treated assumptions were used for all treated commodities.  For the
chronic dietary analysis, tolerance level residues for most commodities;
average field trial residues for pome fruit, head lettuce, leaf lettuce,
spinach, tomato, lemon, and grapes; and 100% crop treated assumptions
were used.  Default processing factors were used for most processed
commodities, except for tomato paste/puree in the chronic(1x) and
lemon/lime juice (1x).  Residues used in the acute and chronic dietary
analysis are provided in Table 2.  Average residues where noted were
used in the chronic dietary analysis.

Table 2. Residue Estimates Used in the Cyprodinil Acute and Chronic
Dietary/Drinking Water Analysis

Commodity	Tolerance (ppm)

Crop Subgroup 1B, except sugarbeet	0.75

Crop Group 2 	10

Onion, bulb subgroup 3-07A	0.6

Onion, green subgroup 3-07B	4.0

Crop Subgroup 4A (except spinach) 	30 tolerance/0.87 avg head lettuce

30 tolerance/13 avg leaf lettuce

Crop Subgroup 4B	30

Crop Subgroup 5A Head and stem 	1.0

Crop Subgroup 5B Leafy Brassica greens 	10

Bean, dry; Bean, succulent	0.6

Vegetable, fruiting, group 8-10	1.5

Crop Group 9	0.7

Lemon, Lime	0.6

Citrus Oil	Decreased to 60

Pome fruit, Crop group 11-10	1.7 tolerance/0.50 avg apple

1.7 tolerance/0.38 avg pear

Stone fruit, Crop group 12	2

Caneberry, subgroup 13-07A	10

Bushberry subgroup 13-07B	3

Small fruit vine climbing subgroup 13-07F, except fuzzy kiwifruit	2.0
tolerance/0.81 avg grapes

Low growing berry subgroup 13-07G, except cranberry	5.0 (inc.
strawberry)

Almond	0.02

Pistachio	0.1

Crop Subgroup 19A Herb Fresh (except parsley)               	3

Crop Subgroup 19A Herb Dried (except parsley)               	15

Parsley, dried leaves            	170

Parsley leaves	35

Rape seed oil (canola, seed)	0.03

Avocado,  Canistel; Mango; Papaya; Sapodilla; Sapote, black; Sapote,
mamey; Star apple	1.2

Dragonfruit	2.0

Kiwifruit	1.8

Watercress	20

Beef, Goat, Horse, Sheep, meat byproducts (including liver and kidney )
0.02

Grape, raisin	3.0

Turnip, greens	10.0

III.	Water Data

Drinking water residues were incorporated directly into the acute and
chronic dietary analyses as “water, direct, all sources” and
“water, indirect, all sources” and were provided by the
Environmental Fate and Effects Division (EFED) (D391853, J Melendez
11/4/11).  EFED generated the surface water estimates using the linked
Pesticide Root Zone/Exposure Analysis Modeling System (PRZM-EXAMS) Tier
2 aquatic models.  Ground water estimates were calculated using the  SEQ
CHAPTER \h \r 1  Tier 1 Screening Concentration In GROund Water
(SCI-GROW) model.   Estimated Drinking Water Concentrations (EDWCs) for
cyprodinil and its metabolite CGA-249287 were derived based on a maximum
application rate of 0.47 lb a.i./A applied 3 times/year, or 1.4 lb
a.i./A/year, on grapes.   The concentrations have been adjusted with the
Percent Crop Area (PCA) of 0.87 for a national assessment.  Combined
surface water EDWCs for cyprodinil and CGA-249287 used in the exposure
assessment, are provided in Table 3.  

Table 3.  EDWCs for the Cyprodinil Human Health Risk Assessment 

Drinking Water Source	Peak (μg/L)	Annual Mean (μg/L)

Surface Water	34.79	24.65

Ground Water	0.0861	0.0861

IV.	DEEM-FCID™ Program and Consumption Information

Cyprodinil chronic dietary exposure assessments were conducted using the
Dietary Exposure Evaluation Model software with the Food Commodity
Intake Database (DEEM-FCID™, Version 2.03), which incorporates
consumption data from USDA’s Continuing Surveys of Food Intakes by
Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98 data are based
on the reported consumption of more than 20,000 individuals over two
non-consecutive survey days.  Foods “as consumed” (e.g., apple pie)
are linked to EPA-defined food commodities (e.g. apples, peeled fruit -
cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S,
baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA.  For chronic exposure assessment,
consumption data are averaged for the entire U.S. population and within
population subgroups, but for acute exposure assessment are retained as
individual consumption events.  Based on analysis of the 1994-96, 98
CSFII consumption data, which took into account dietary patterns and
survey respondents, HED concluded that it is most appropriate to report
risk for the following population subgroups: the general U.S.
population, all infants (<1 year old), children 1-2, children 3-5,
children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+
years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form.  The resulting residue
consumption estimate for each food/food form is summed with the residue
consumption estimates for all other food/food forms on the commodity
residue list to arrive at the total average estimated exposure. 
Exposure is expressed in mg/kg body weight/day and as a percent of the
cPAD.  This procedure is performed for each population subgroup.

V.	Toxicological Information

HED evaluated the toxicology data base for cyprodinil and selected doses
and endpoints for  chronic dietary and drinking water risk assessments
provided in Table 4.  

Table 4. Summary of Toxicological Doses and Endpoints for Cyprodinil 
for Use in Dietary Human Health Risk Assessments

Exposure/Scenario	Point of Departure	Uncertainty/FQPA Safety Factors
RfD, PAD, LOC for Risk Assessment	Study and Toxicological Effects

Acute Dietary

(All Populations)	

NOAEL = 200 mg/kg/day	

UFA= 10x

UFH=10x

FQPA SF= 1x	

Acute RfD = 2.0 mg/kg/day           aPAD = 2.0 mg/kg/day    

	Acute Neurotoxicity - Rat

LOAEL = 600 mg/kg/day based on clinical signs of toxicity, low motor
activity and reversible hypothermia

Chronic Dietary 

(All Populations)	NOAEL= 2.7 mg/kg/day	UFA = 10x

UFH =10x

FQPA SF= 1x	Chronic RfD = 0.027

mg/kg/day

cPAD = 0.027mg/kg/day	2-Year Chronic Toxicity/ Carcinogenicity- rat

LOAEL = 35.6 mg/kg/day based on degenerative liver lesions (spongiosis
hepatis) in males.

Cancer (all routes)	Classification: “Not likely to be carcinogenic to
humans”

Point of Departure (POD) = A data point or an estimated point that is
derived from observed dose-response data and  used to mark the beginning
of extrapolation to determine risk associated with lower environmentally
relevant human exposures.  

NOAEL = no observed adverse effect level.  

LOAEL = lowest observed adverse effect level.  

UF = uncertainty factor.  

UFA = extrapolation from animal to human (interspecies).  

UFH = potential variation in sensitivity among members of the human
population (intraspecies).  

FQPA SF = FQPA Safety Factor.  

PAD = population adjusted dose (a = acute, c = chronic).  

RfD = reference dose.  

VI.	Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned
when dietary risk exceeds 100% of the PAD.  The DEEM-FCID™ analyses
estimate the dietary exposure of the U.S. population and various
population subgroups.  The results reported in Tables 5 & 6 are for the
general U.S. Population, all infants (<1 year old), children 1-2,
children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49,
and adults 50+ years.

Results of Acute Dietary Exposure Analysis

The results of the acute dietary exposure analysis are reported in Table
5.  

Table 5:  Summary of Acute Dietary Exposure and Risk for Cyprodinil

Population Subgroup	aPAD (mg/kg/day)	Acute (95th Percentile)

Exposure (mg/kg/day)	%aPAD

General U.S. Population	2.0	0.095794	4.8

All Infants (< 1 year old)

0.102882	5.1

Children 1-2 years old

0.151445	7.6

Children 3-5 years old

0.131883	6.6

Children 6-12 years old

0.098193	4.9

Youth 13-19 years old

0.080270	4.0

Adults 20-49 years old

0.092162	4.6

Adults 50+ years old

0.085400	4.3

Females 13-49 years old

0.099465	5.0

Results of Chronic Dietary Exposure Analysis

The results of the chronic dietary exposure analysis are reported in
Table 6.  

Table 6:  Summary of Chronic Dietary Exposure and Risk for Cyprodinil

Population Subgroup	cPAD (mg/kg/day)	Chronic

Exposure (mg/kg/day)	% cPAD

General U.S. Population	0.027	0.007421	28

All Infants (< 1 year old)

0.014099	52

Children 1-2 years old

0.020269	75

Children 3-5 years old

0.015148	56

Children 6-12 years old

0.008552	32

Youth 13-19 years old

0.005195	19

Adults 20-49 years old

0.005818	22

Adults 50+ years old

0.007260	27

Females 13-49 years old

0.006066	23

VII.   Characterization of Inputs/Outputs

For the acute dietary analysis, tolerance level residues and 100% crop
treated assumptions were used for all treated commodities.  For the
chronic dietary analysis, tolerance level residues for most commodities;
average field trial residues for pome fruit, head lettuce, leaf lettuce,
spinach, tomatoes, lemon, and grapes; and 100% crop treated assumptions
were used.  Default processing factors were used for all processed
commodities except tomato paste/puree (1x) and and lemon/lime juice
(1x).  Residues do not warrant further refinement at this time.

VIII.	Conclusions

An acute and chronic dietary exposure analyses was performed for the
general U.S. population and various population subgroups.  The acute and
chronic risk estimates are below HED’s level of concern.  HED is
confident the acute and chronic dietary exposures to cyprodinil are not
underestimated.

IX.	List of Attachments

1.  Acute DEEM-FCID Residue Input File.

2.  Results of Acute DEEM-FCID Dietary Exposure Analysis.

3.  Chronic DEEM-FCID Residue Input File.

4.  Results of Chronic DEEM-FCID Dietary Exposure Analysis.

Attachment 1 Acute DEEM-FCID Residue Input File

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM
Files\288202 Cyprodinil\Leafy Petioles 1E7869 and Misc
1E7854\288202acuteEPArecommendations.R98

Chemical: cyprodinil

RfD(Chronic): .03 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 2 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 03-13-2012/10:38:56/8          Program ver.
2.03

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

01010500 1AB  Beet, garden, roots                0.750000   1.000  1.000
 

01010501 1AB  Beet, garden, roots-babyfood       0.750000   1.000  1.000
 

01010670 1AB  Burdock                            0.750000   1.000  1.000
 

01010780 1AB  Carrot                             0.750000   1.000  1.000
 

01010781 1AB  Carrot-babyfood                    0.750000   1.000  1.000
 

01010790 1AB  Carrot, juice                      0.750000   1.000  1.000
 

01010840 1AB  Celeriac                           0.750000   1.000  1.000
 

01011000 1AB  Chicory, roots                     0.750000   1.000  1.000
 

01011680 1AB  Ginseng, dried                     0.750000   1.000  1.000
 

01011900 1AB  Horseradish                        0.750000   1.000  1.000
 

01012500 1AB  Parsley, turnip rooted             0.750000   1.000  1.000
 

01012510 1AB  Parsnip                            0.750000   1.000  1.000
 

01012511 1AB  Parsnip-babyfood                   0.750000   1.000  1.000
 

01013140 1AB  Radish, roots                      0.750000   1.000  1.000
 

01013160 1AB  Radish, Oriental, roots            0.750000   1.000  1.000
 

01013270 1AB  Rutabaga                           0.750000   1.000  1.000
 

01013310 1AB  Salsify, roots                     0.750000   1.000  1.000
 

01013880 1AB  Turnip, roots                      0.750000   1.000  1.000
 

02000510 2    Beet, garden, tops                10.000000   1.000  1.000
 

02001010 2    Chicory, tops                     10.000000   1.000  1.000
 

02001400 2    Dasheen, leaves                   10.000000   1.000  1.000
 

02003150 2    Radish, tops                      10.000000   1.000  1.000
 

02003170 2    Radish, Oriental, tops            10.000000   1.000  1.000
 

02003320 2    Salsify, tops                     10.000000   1.000  1.000
 

03001640 3    Garlic                             0.600000   1.000  1.000
 

03001650 3    Garlic, dried                      0.600000   1.000  1.000
 

03001651 3    Garlic, dried-babyfood             0.600000   1.000  1.000
 

03001980 3    Leek                               4.000000   1.000  1.000
 

03002370 3    Onion, dry bulb                    0.600000   1.000  1.000
 

03002371 3    Onion, dry bulb-babyfood           0.600000   1.000  1.000
 

03002380 3    Onion, dry bulb, dried             0.600000   9.000  1.000
 

03002381 3    Onion, dry bulb, dried-babyfood    0.600000   9.000  1.000
 

03002390 3    Onion, green                       4.000000   1.000  1.000
 

03003380 3    Shallot                            4.000000   1.000  1.000
 

04010050 4A   Amaranth, leafy                   50.000000   1.000  1.000
 

04010180 4A   Arugula                           50.000000   1.000  1.000
 

04011040 4A   Chrysanthemum, garland            50.000000   1.000  1.000
 

04011330 4A   Cress, garden                     50.000000   1.000  1.000
 

04011340 4A   Cress, upland                     50.000000   1.000  1.000
 

04011380 4A   Dandelion, leaves                 50.000000   1.000  1.000
 

04011500 4A   Endive                            50.000000   1.000  1.000
 

04012040 4A   Lettuce, head                     50.000000   1.000  1.000
 

04012050 4A   Lettuce, leaf                     50.000000   1.000  1.000
 

04012480 4A   Parsley, leaves                   50.000000   1.000  1.000
 

04013130 4A   Radicchio                         50.000000   1.000  1.000
 

04013550 4A   Spinach                           50.000000   1.000  1.000
 

04013551 4A   Spinach-babyfood                  50.000000   1.000  1.000
 

04020760 4B   Cardoon                           30.000000   1.000  1.000
 

04020850 4B   Celery                            30.000000   1.000  1.000
 

04020851 4B   Celery-babyfood                   30.000000   1.000  1.000
 

04020860 4B   Celery, juice                     30.000000   1.000  1.000
 

04020870 4B   Celtuce                           30.000000   1.000  1.000
 

04021520 4B   Fennel, Florence                  30.000000   1.000  1.000
 

04023220 4B   Rhubarb                           30.000000   1.000  1.000
 

04023670 4B   Swiss chard                       30.000000   1.000  1.000
 

05010610 5A   Broccoli                           1.000000   1.000  1.000
 

05010611 5A   Broccoli-babyfood                  1.000000   1.000  1.000
 

05010620 5A   Broccoli, Chinese                  1.000000   1.000  1.000
 

05010640 5A   Brussels sprouts                   1.000000   1.000  1.000
 

05010690 5A   Cabbage                            1.000000   1.000  1.000
 

05010710 5A   Cabbage, Chinese, napa             1.000000   1.000  1.000
 

05010720 5A   Cabbage, Chinese, mustard          1.000000   1.000  1.000
 

05010830 5A   Cauliflower                        1.000000   1.000  1.000
 

05011960 5A   Kohlrabi                           1.000000   1.000  1.000
 

05020630 5B   Broccoli raab                     10.000000   1.000  1.000
 

05020700 5B   Cabbage, Chinese, bok choy        10.000000   1.000  1.000
 

05021170 5B   Collards                          10.000000   1.000  1.000
 

05021940 5B   Kale                              10.000000   1.000  1.000
 

05022290 5B   Mustard greens                    10.000000   1.000  1.000
 

05023180 5B   Rape greens                       10.000000   1.000  1.000
 

05023890 5B   Turnip, greens                    10.000000   1.000  1.000
 

06020310 6B   Bean, broad, succulent             0.600000   1.000  1.000
 

06020330 6B   Bean, cowpea, succulent            0.600000   1.000  1.000
 

06020370 6B   Bean, lima, succulent              0.600000   1.000  1.000
 

06030300 6C   Bean, black, seed                  0.600000   1.000  1.000
 

06030320 6C   Bean, broad, seed                  0.600000   1.000  1.000
 

06030340 6C   Bean, cowpea, seed                 0.600000   1.000  1.000
 

06030350 6C   Bean,  great northern, seed        0.600000   1.000  1.000
 

06030360 6C   Bean, kidney, seed                 0.600000   1.000  1.000
 

06030380 6C   Bean, lima, seed                   0.600000   1.000  1.000
 

06030390 6C   Bean, mung, seed                   0.600000   1.000  1.000
 

06030400 6C   Bean, navy, seed                   0.600000   1.000  1.000
 

06030410 6C   Bean, pink, seed                   0.600000   1.000  1.000
 

06030420 6C   Bean, pinto, seed                  0.600000   1.000  1.000
 

06030980 6C   Chickpea, seed                     0.600000   1.000  1.000
 

06030981 6C   Chickpea, seed-babyfood            0.600000   1.000  1.000
 

06030990 6C   Chickpea, flour                    0.600000   1.000  1.000
 

06031820 6C   Guar, seed                         0.600000   1.000  1.000
 

06031821 6C   Guar, seed-babyfood                0.600000   1.000  1.000
 

06032030 6C   Lentil, seed                       0.600000   1.000  1.000
 

08001480 8    Eggplant                           1.500000   1.000  1.000
 

08002340 8    Okra                               1.500000   1.000  1.000
 

08002700 8    Pepper, bell                       1.500000   1.000  1.000
 

08002701 8    Pepper, bell-babyfood              1.500000   1.000  1.000
 

08002710 8    Pepper, bell, dried                1.500000   1.000  1.000
 

08002711 8    Pepper, bell, dried-babyfood       1.500000   1.000  1.000
 

08002720 8    Pepper, nonbell                    1.500000   1.000  1.000
 

08002721 8    Pepper, nonbell-babyfood           1.500000   1.000  1.000
 

08002730 8    Pepper, nonbell, dried             1.500000   1.000  1.000
 

08003740 8    Tomatillo                          1.500000   1.000  1.000
 

08003750 8    Tomato                             1.500000   1.000  1.000
 

08003751 8    Tomato-babyfood                    1.500000   1.000  1.000
 

08003760 8    Tomato, paste                      1.500000   1.000  1.000
 

08003761 8    Tomato, paste-babyfood             1.500000   1.000  1.000
 

08003770 8    Tomato, puree                      1.500000   1.000  1.000
 

08003771 8    Tomato, puree-babyfood             1.500000   1.000  1.000
 

08003780 8    Tomato, dried                      1.500000  14.300  1.000
 

08003781 8    Tomato, dried-babyfood             1.500000  14.300  1.000
 

08003790 8    Tomato, juice                      1.500000   1.000  1.000
 

09010750 9A   Cantaloupe                         0.700000   1.000  1.000
 

09010800 9A   Casaba                             0.700000   1.000  1.000
 

09011870 9A   Honeydew melon                     0.700000   1.000  1.000
 

09013990 9A   Watermelon                         0.700000   1.000  1.000
 

09014000 9A   Watermelon, juice                  0.700000   1.000  1.000
 

09020210 9B   Balsam pear                        0.700000   1.000  1.000
 

09020880 9B   Chayote, fruit                     0.700000   1.000  1.000
 

09021020 9B   Chinese waxgourd                   0.700000   1.000  1.000
 

09021350 9B   Cucumber                           0.700000   1.000  1.000
 

09023080 9B   Pumpkin                            0.700000   1.000  1.000
 

09023090 9B   Pumpkin, seed                      0.700000   1.000  1.000
 

09023560 9B   Squash, summer                     0.700000   1.000  1.000
 

09023561 9B   Squash, summer-babyfood            0.700000   1.000  1.000
 

09023570 9B   Squash, winter                     0.700000   1.000  1.000
 

09023571 9B   Squash, winter-babyfood            0.700000   1.000  1.000
 

10001080 10   Citrus, oil                       60.000000   1.000  1.000
 

10001990 10   Lemon                              0.600000   1.000  1.000
 

10002000 10   Lemon, juice                       0.600000   1.000  1.000
 

10002001 10   Lemon, juice-babyfood              0.600000   1.000  1.000
 

10002010 10   Lemon, peel                        0.600000   1.000  1.000
 

10002060 10   Lime                               0.600000   1.000  1.000
 

10002070 10   Lime, juice                        0.600000   1.000  1.000
 

10002071 10   Lime, juice-babyfood               0.600000   1.000  1.000
 

11000070 11   Apple, fruit with peel             1.700000   1.000  1.000
 PP#0F7

          Full comment: PP#0F7696

11000080 11   Apple, peeled fruit                1.700000   1.000  1.000
 PP#0F7

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11000081 11   Apple, peeled fruit-babyfood       1.700000   1.000  1.000
 PP#0F7

          Full comment: PP#0F7696

11000090 11   Apple, dried                       1.700000   8.000  1.000
 PP#0F7

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11000091 11   Apple, dried-babyfood              1.700000   8.000  1.000
 PP#0F7

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11000100 11   Apple, juice                       1.700000   1.300  1.000
 PP#0F7

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11000101 11   Apple, juice-babyfood              1.700000   1.300  1.000
 PP#0F7

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11000110 11   Apple, sauce                       1.700000   1.000  1.000
 PP#0F7

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11000111 11   Apple, sauce-babyfood              1.700000   1.000  1.000
 PP#0F7

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11001290 11   Crabapple                          1.700000   1.000  1.000
 PP#0F7

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11002100 11   Loquat                             1.700000   1.000  1.000
 PP#0F7

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11002660 11   Pear                               1.700000   1.000  1.000
 PP#0F7

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11002661 11   Pear-babyfood                      1.700000   1.000  1.000
 PP#0F7

          Full comment: PP#0F7696

11002670 11   Pear, dried                        1.700000   6.250  1.000
 PP#0F7

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11002680 11   Pear, juice                        1.700000   1.000  1.000
 PP#0F7

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11002681 11   Pear, juice-babyfood               1.700000   1.000  1.000
 PP#0F7

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11003100 11   Quince                             1.700000   1.000  1.000
 PP#0F7

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12000120 12   Apricot                            2.000000   1.000  1.000
 

12000121 12   Apricot-babyfood                   2.000000   1.000  1.000
 

12000130 12   Apricot, dried                     2.000000   6.000  1.000
 

12000140 12   Apricot, juice                     2.000000   1.000  1.000
 

12000141 12   Apricot, juice-babyfood            2.000000   1.000  1.000
 

12000900 12   Cherry                             2.000000   1.000  1.000
 

12000901 12   Cherry-babyfood                    2.000000   1.000  1.000
 

12000910 12   Cherry, juice                      2.000000   1.500  1.000
 

12000911 12   Cherry, juice-babyfood             2.000000   1.500  1.000
 

12002300 12   Nectarine                          2.000000   1.000  1.000
 

12002600 12   Peach                              2.000000   1.000  1.000
 

12002601 12   Peach-babyfood                     2.000000   1.000  1.000
 

12002610 12   Peach, dried                       2.000000   7.000  1.000
 

12002611 12   Peach, dried-babyfood              2.000000   7.000  1.000
 

12002620 12   Peach, juice                       2.000000   1.000  1.000
 

12002621 12   Peach, juice-babyfood              2.000000   1.000  1.000
 

12002850 12   Plum                               2.000000   1.000  1.000
 

12002851 12   Plum-babyfood                      2.000000   1.000  1.000
 

12002860 12   Plum, prune, fresh                 2.000000   1.000  1.000
 

12002861 12   Plum, prune, fresh-babyfood        2.000000   1.000  1.000
 

12002870 12   Plum, prune, dried                 2.000000   5.000  1.000
 

12002871 12   Plum, prune, dried-babyfood        2.000000   5.000  1.000
 

12002880 12   Plum, prune, juice                 2.000000   1.400  1.000
 

12002881 12   Plum, prune, juice-babyfood        2.000000   1.400  1.000
 

13010550 13A  Blackberry                        10.000000   1.000  1.000
 

13010560 13A  Blackberry, juice                 10.000000   1.000  1.000
 

13010561 13A  Blackberry, juice-babyfood        10.000000   1.000  1.000
 

13010580 13A  Boysenberry                       10.000000   1.000  1.000
 

13011420 13A  Dewberry                          10.000000   1.000  1.000
 

13012080 13A  Loganberry                        10.000000   1.000  1.000
 

13013200 13A  Raspberry                         10.000000   1.000  1.000
 

13013201 13A  Raspberry-babyfood                10.000000   1.000  1.000
 

13013210 13A  Raspberry, juice                  10.000000   1.000  1.000
 

13013211 13A  Raspberry, juice-babyfood         10.000000   1.000  1.000
 

13020570 13B  Blueberry                          3.000000   1.000  1.000
 

13020571 13B  Blueberry-babyfood                 3.000000   1.000  1.000
 

13021360 13B  Currant                            3.000000   1.000  1.000
 

13021370 13B  Currant, dried                     3.000000   1.000  1.000
 

13021490 13B  Elderberry                         3.000000   1.000  1.000
 

13021740 13B  Gooseberry                         3.000000   1.000  1.000
 

13021910 13B  Huckleberry                        3.000000   1.000  1.000
 

14000030 14   Almond                             0.020000   1.000  1.000
 

14000031 14   Almond-babyfood                    0.020000   1.000  1.000
 

14000040 14   Almond, oil                        0.020000   1.000  1.000
 

14000041 14   Almond, oil-babyfood               0.020000   1.000  1.000
 

14002820 14   Pistachio                          0.100000   1.000  1.000
 

19010280 19A  Basil, fresh leaves                3.000000   1.000  1.000
 

19010281 19A  Basil, fresh leaves-babyfood       3.000000   1.000  1.000
 

19010290 19A  Basil, dried leaves               15.000000   1.000  1.000
 

19010291 19A  Basil, dried leaves-babyfood      15.000000   1.000  1.000
 

19011030 19A  Chive                              3.000000   1.000  1.000
 

19011180 19A  Coriander, leaves                  3.000000   1.000  1.000
 

19011181 19A  Coriander, leaves-babyfood         3.000000   1.000  1.000
 

19011440 19A  Dillweed                           3.000000   1.000  1.000
 

19011840 19A  Herbs, other                       3.000000   1.000  1.000
 

19011841 19A  Herbs, other-babyfood              3.000000   1.000  1.000
 

19012020 19A  Lemongrass                         3.000000   1.000  1.000
 

19012200 19A  Marjoram                           3.000000   1.000  1.000
 

19012201 19A  Marjoram-babyfood                  3.000000   1.000  1.000
 

19012490 19A  Parsley, dried leaves            170.000000   1.000  1.000
 

19012491 19A  Parsley, dried leaves-babyfood   170.000000   1.000  1.000
 

19013340 19A  Savory                             3.000000   1.000  1.000
 

20003190 20   Rapeseed, oil                      0.030000   1.000  1.000
 

20003191 20   Rapeseed, oil-babyfood             0.030000   1.000  1.000
 

21000460 M    Beef, meat byproducts              0.020000   1.000  1.000
 

21000461 M    Beef, meat byproducts-babyfood     0.020000   1.000  1.000
 

21000480 M    Beef, kidney                       0.020000   1.000  1.000
 

21000490 M    Beef, liver                        0.020000   1.000  1.000
 

21000491 M    Beef, liver-babyfood               0.020000   1.000  1.000
 

23001700 M    Goat, meat byproducts              0.020000   1.000  1.000
 

23001720 M    Goat, kidney                       0.020000   1.000  1.000
 

23001730 M    Goat, liver                        0.020000   1.000  1.000
 

26003400 M    Sheep, meat byproducts             0.020000   1.000  1.000
 

26003420 M    Sheep, kidney                      0.020000   1.000  1.000
 

26003430 M    Sheep, liver                       0.020000   1.000  1.000
 

86010000 O    Water, direct, all sources         0.034790   1.000  1.000
 

86020000 O    Water, indirect, all sources       0.034790   1.000  1.000
 

95000200 O    Avocado                            1.200000   1.000  1.000
 

95000740 O    Canistel                           1.200000   1.000  1.000
 

95001750 O    Grape                              2.000000   1.000  1.000
 

95001760 O    Grape, juice                       2.000000   1.200  1.000
 

95001761 O    Grape, juice-babyfood              2.000000   1.200  1.000
 

95001770 O    Grape, leaves                      2.000000   1.000  1.000
 

95001780 O    Grape, raisin                      3.000000   1.000  1.000
 

95001790 O    Grape, wine and sherry             2.000000   1.000  1.000
 

95001950 O    Kiwifruit                          1.800000   1.000  1.000
 

95002090 O    Longan                             2.000000   1.000  1.000
 

95002110 O    Lychee                             2.000000   1.000  1.000
 

95002120 O    Lychee, dried                      2.000000   1.850  1.000
 

95002150 O    Mango                              1.200000   1.000  1.000
 

95002151 O    Mango-babyfood                     1.200000   1.000  1.000
 

95002160 O    Mango, dried                       1.200000   1.000  1.000
 

95002170 O    Mango, juice                       1.200000   1.000  1.000
 

95002171 O    Mango, juice-babyfood              1.200000   1.000  1.000
 

95002450 O    Papaya                             1.200000   1.000  1.000
 

95002451 O    Papaya-babyfood                    1.200000   1.000  1.000
 

95002460 O    Papaya, dried                      1.200000   1.800  1.000
 

95002470 O    Papaya, juice                      1.200000   1.500  1.000
 

95003330 O    Sapote, Mamey                      1.200000   1.000  1.000
 

95003510 O    Spanish lime                       2.000000   1.000  1.000
 

95003590 O    Strawberry                         5.000000   1.000  1.000
 

95003591 O    Strawberry-babyfood                5.000000   1.000  1.000
 

95003600 O    Strawberry, juice                  5.000000   1.000  1.000
 

95003601 O    Strawberry, juice-babyfood         5.000000   1.000  1.000
 

95003980 O    Watercress                        20.000000   1.000  1.000
 

Attachment 2 Chronic DEEM-FCID Residue Input File

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM
Files\288202 Cyprodinil\Leafy Petioles 1E7869 and Misc
1E7854\288202chronicEPArecommendations.R98

Chemical: cyprodinil

RfD(Chronic): .03 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 1.5 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 03-13-2012/10:58:02/8          Program ver.
2.03

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

01010500 1AB  Beet, garden, roots                0.750000   1.000  1.000
 

01010501 1AB  Beet, garden, roots-babyfood       0.750000   1.000  1.000
 

01010670 1AB  Burdock                            0.750000   1.000  1.000
 

01010780 1AB  Carrot                             0.750000   1.000  1.000
 

01010781 1AB  Carrot-babyfood                    0.750000   1.000  1.000
 

01010790 1AB  Carrot, juice                      0.750000   1.000  1.000
 

01010840 1AB  Celeriac                           0.750000   1.000  1.000
 

01011000 1AB  Chicory, roots                     0.750000   1.000  1.000
 

01011680 1AB  Ginseng, dried                     0.750000   1.000  1.000
 

01011900 1AB  Horseradish                        0.750000   1.000  1.000
 

01012500 1AB  Parsley, turnip rooted             0.750000   1.000  1.000
 

01012510 1AB  Parsnip                            0.750000   1.000  1.000
 

01012511 1AB  Parsnip-babyfood                   0.750000   1.000  1.000
 

01013140 1AB  Radish, roots                      0.750000   1.000  1.000
 

01013160 1AB  Radish, Oriental, roots            0.750000   1.000  1.000
 

01013270 1AB  Rutabaga                           0.750000   1.000  1.000
 

01013310 1AB  Salsify, roots                     0.750000   1.000  1.000
 

01013880 1AB  Turnip, roots                      0.750000   1.000  1.000
 

02000510 2    Beet, garden, tops                10.000000   1.000  1.000
 

02001010 2    Chicory, tops                     10.000000   1.000  1.000
 

02001400 2    Dasheen, leaves                   10.000000   1.000  1.000
 

02003150 2    Radish, tops                      10.000000   1.000  1.000
 

02003170 2    Radish, Oriental, tops            10.000000   1.000  1.000
 

02003320 2    Salsify, tops                     10.000000   1.000  1.000
 

03001640 3    Garlic                             0.600000   1.000  1.000
 

03001650 3    Garlic, dried                      0.600000   1.000  1.000
 

03001651 3    Garlic, dried-babyfood             0.600000   1.000  1.000
 

03001980 3    Leek                               4.000000   1.000  1.000
 

03002370 3    Onion, dry bulb                    0.600000   1.000  1.000
 

03002371 3    Onion, dry bulb-babyfood           0.600000   1.000  1.000
 

03002380 3    Onion, dry bulb, dried             0.600000   9.000  1.000
 

03002381 3    Onion, dry bulb, dried-babyfood    0.600000   9.000  1.000
 

03002390 3    Onion, green                       4.000000   1.000  1.000
 

03003380 3    Shallot                            4.000000   1.000  1.000
 

04010050 4A   Amaranth, leafy                   50.000000   1.000  1.000
 

04010180 4A   Arugula                           50.000000   1.000  1.000
 

04011040 4A   Chrysanthemum, garland            50.000000   1.000  1.000
 

04011330 4A   Cress, garden                     50.000000   1.000  1.000
 

04011340 4A   Cress, upland                     50.000000   1.000  1.000
 

04011380 4A   Dandelion, leaves                 50.000000   1.000  1.000
 

04011500 4A   Endive                            50.000000   1.000  1.000
 

04012040 4A   Lettuce, head                      0.870000   1.000  1.000
 

04012050 4A   Lettuce, leaf                     13.000000   1.000  1.000
 

04012480 4A   Parsley, leaves                   35.000000   1.000  1.000
 

04013130 4A   Radicchio                         50.000000   1.000  1.000
 

04013550 4A   Spinach                           11.800000   1.000  1.000
 

04013551 4A   Spinach-babyfood                  11.800000   1.000  1.000
 

04020760 4B   Cardoon                           30.000000   1.000  1.000
 

04020850 4B   Celery                            30.000000   1.000  1.000
 

04020851 4B   Celery-babyfood                   30.000000   1.000  1.000
 

04020860 4B   Celery, juice                     30.000000   1.000  1.000
 

04020870 4B   Celtuce                           30.000000   1.000  1.000
 

04021520 4B   Fennel, Florence                  30.000000   1.000  1.000
 

04023220 4B   Rhubarb                           30.000000   1.000  1.000
 

04023670 4B   Swiss chard                       30.000000   1.000  1.000
 

05010610 5A   Broccoli                           1.000000   1.000  1.000
 

05010611 5A   Broccoli-babyfood                  1.000000   1.000  1.000
 

05010620 5A   Broccoli, Chinese                  1.000000   1.000  1.000
 

05010640 5A   Brussels sprouts                   1.000000   1.000  1.000
 

05010690 5A   Cabbage                            1.000000   1.000  1.000
 

05010710 5A   Cabbage, Chinese, napa             1.000000   1.000  1.000
 

05010720 5A   Cabbage, Chinese, mustard          1.000000   1.000  1.000
 

05010830 5A   Cauliflower                        1.000000   1.000  1.000
 

05011960 5A   Kohlrabi                           1.000000   1.000  1.000
 

05020630 5B   Broccoli raab                     10.000000   1.000  1.000
 

05020700 5B   Cabbage, Chinese, bok choy        10.000000   1.000  1.000
 

05021170 5B   Collards                          10.000000   1.000  1.000
 

05021940 5B   Kale                              10.000000   1.000  1.000
 

05022290 5B   Mustard greens                    10.000000   1.000  1.000
 

05023180 5B   Rape greens                       10.000000   1.000  1.000
 

05023890 5B   Turnip, greens                    10.000000   1.000  1.000
 

06020310 6B   Bean, broad, succulent             0.600000   1.000  1.000
 

06020330 6B   Bean, cowpea, succulent            0.600000   1.000  1.000
 

06020370 6B   Bean, lima, succulent              0.600000   1.000  1.000
 

06030300 6C   Bean, black, seed                  0.600000   1.000  1.000
 

06030320 6C   Bean, broad, seed                  0.600000   1.000  1.000
 

06030340 6C   Bean, cowpea, seed                 0.600000   1.000  1.000
 

06030350 6C   Bean,  great northern, seed        0.600000   1.000  1.000
 

06030360 6C   Bean, kidney, seed                 0.600000   1.000  1.000
 

06030380 6C   Bean, lima, seed                   0.600000   1.000  1.000
 

06030390 6C   Bean, mung, seed                   0.600000   1.000  1.000
 

06030400 6C   Bean, navy, seed                   0.600000   1.000  1.000
 

06030410 6C   Bean, pink, seed                   0.600000   1.000  1.000
 

06030420 6C   Bean, pinto, seed                  0.600000   1.000  1.000
 

06030980 6C   Chickpea, seed                     0.600000   1.000  1.000
 

06030981 6C   Chickpea, seed-babyfood            0.600000   1.000  1.000
 

06030990 6C   Chickpea, flour                    0.600000   1.000  1.000
 

06031820 6C   Guar, seed                         0.600000   1.000  1.000
 

06031821 6C   Guar, seed-babyfood                0.600000   1.000  1.000
 

06032030 6C   Lentil, seed                       0.600000   1.000  1.000
 

08001480 8    Eggplant                           1.500000   1.000  1.000
 

08002340 8    Okra                               1.500000   1.000  1.000
 

08002700 8    Pepper, bell                       1.500000   1.000  1.000
 

08002701 8    Pepper, bell-babyfood              1.500000   1.000  1.000
 

08002710 8    Pepper, bell, dried                1.500000   1.000  1.000
 

08002711 8    Pepper, bell, dried-babyfood       1.500000   1.000  1.000
 

08002720 8    Pepper, nonbell                    1.500000   1.000  1.000
 

08002721 8    Pepper, nonbell-babyfood           1.500000   1.000  1.000
 

08002730 8    Pepper, nonbell, dried             1.500000   1.000  1.000
 

08003740 8    Tomatillo                          0.160000   1.000  1.000
 

08003750 8    Tomato                             0.160000   1.000  1.000
 

08003751 8    Tomato-babyfood                    0.160000   1.000  1.000
 

08003760 8    Tomato, paste                      0.160000   1.000  1.000
 

08003761 8    Tomato, paste-babyfood             0.160000   1.000  1.000
 

08003770 8    Tomato, puree                      0.160000   1.000  1.000
 

08003771 8    Tomato, puree-babyfood             0.160000   1.000  1.000
 

08003780 8    Tomato, dried                      0.160000  14.300  1.000
 

08003781 8    Tomato, dried-babyfood             0.160000  14.300  1.000
 

08003790 8    Tomato, juice                      0.160000   1.000  1.000
 

09010750 9A   Cantaloupe                         0.700000   1.000  1.000
 

09010800 9A   Casaba                             0.700000   1.000  1.000
 

09011870 9A   Honeydew melon                     0.700000   1.000  1.000
 

09013990 9A   Watermelon                         0.700000   1.000  1.000
 

09014000 9A   Watermelon, juice                  0.700000   1.000  1.000
 

09020210 9B   Balsam pear                        0.700000   1.000  1.000
 

09020880 9B   Chayote, fruit                     0.700000   1.000  1.000
 

09021020 9B   Chinese waxgourd                   0.700000   1.000  1.000
 

09021350 9B   Cucumber                           0.700000   1.000  1.000
 

09023080 9B   Pumpkin                            0.700000   1.000  1.000
 

09023090 9B   Pumpkin, seed                      0.700000   1.000  1.000
 

09023560 9B   Squash, summer                     0.700000   1.000  1.000
 

09023561 9B   Squash, summer-babyfood            0.700000   1.000  1.000
 

09023570 9B   Squash, winter                     0.700000   1.000  1.000
 

09023571 9B   Squash, winter-babyfood            0.700000   1.000  1.000
 

10001080 10   Citrus, oil                       60.000000   1.000  1.000
 

10001990 10   Lemon                              0.260000   1.000  1.000
 

10002000 10   Lemon, juice                       0.260000   1.000  1.000
 

10002001 10   Lemon, juice-babyfood              0.260000   1.000  1.000
 

10002010 10   Lemon, peel                        0.260000   1.000  1.000
 

10002060 10   Lime                               0.260000   1.000  1.000
 

10002070 10   Lime, juice                        0.260000   1.000  1.000
 

10002071 10   Lime, juice-babyfood               0.260000   1.000  1.000
 

11000070 11   Apple, fruit with peel             0.500000   1.000  1.000
 PP#0F7

          Full comment: PP#0F7696

11000080 11   Apple, peeled fruit                0.500000   1.000  1.000
 PP#0F7

          Full comment: PP#0F7696

11000081 11   Apple, peeled fruit-babyfood       0.500000   1.000  1.000
 PP#0F7

          Full comment: PP#0F7696

11000090 11   Apple, dried                       0.500000   8.000  1.000
 PP#0F7

          Full comment: PP#0F7696

11000091 11   Apple, dried-babyfood              0.500000   8.000  1.000
 PP#0F7

          Full comment: PP#0F7696

11000100 11   Apple, juice                       0.500000   1.300  1.000
 PP#0F7

          Full comment: PP#0F7696

11000101 11   Apple, juice-babyfood              0.500000   1.300  1.000
 PP#0F7

          Full comment: PP#0F7696

11000110 11   Apple, sauce                       0.500000   1.000  1.000
 PP#0F7

          Full comment: PP#0F7696

11000111 11   Apple, sauce-babyfood              0.500000   1.000  1.000
 PP#0F7

          Full comment: PP#0F7696

11001290 11   Crabapple                          0.500000   1.000  1.000
 PP#0F7

          Full comment: PP#0F7696

11002100 11   Loquat                             0.500000   1.000  1.000
 PP#0F7

          Full comment: PP#0F7696

11002660 11   Pear                               0.380000   1.000  1.000
 PP#0F7

          Full comment: PP#0F7696

11002661 11   Pear-babyfood                      0.380000   1.000  1.000
 PP#0F7

          Full comment: PP#0F7696

11002670 11   Pear, dried                        0.380000   6.250  1.000
 PP#0F7

          Full comment: PP#0F7696

11002680 11   Pear, juice                        0.380000   1.000  1.000
 PP#0F7

          Full comment: PP#0F7696

11002681 11   Pear, juice-babyfood               0.380000   1.000  1.000
 PP#0F7

          Full comment: PP#0F7696

11003100 11   Quince                             0.500000   1.000  1.000
 PP#0F7

          Full comment: PP#0F7696

12000120 12   Apricot                            2.000000   1.000  1.000
 

12000121 12   Apricot-babyfood                   2.000000   1.000  1.000
 

12000130 12   Apricot, dried                     2.000000   6.000  1.000
 

12000140 12   Apricot, juice                     2.000000   1.000  1.000
 

12000141 12   Apricot, juice-babyfood            2.000000   1.000  1.000
 

12000900 12   Cherry                             2.000000   1.000  1.000
 

12000901 12   Cherry-babyfood                    2.000000   1.000  1.000
 

12000910 12   Cherry, juice                      2.000000   1.500  1.000
 

12000911 12   Cherry, juice-babyfood             2.000000   1.500  1.000
 

12002300 12   Nectarine                          2.000000   1.000  1.000
 

12002600 12   Peach                              2.000000   1.000  1.000
 

12002601 12   Peach-babyfood                     2.000000   1.000  1.000
 

12002610 12   Peach, dried                       2.000000   7.000  1.000
 

12002611 12   Peach, dried-babyfood              2.000000   7.000  1.000
 

12002620 12   Peach, juice                       2.000000   1.000  1.000
 

12002621 12   Peach, juice-babyfood              2.000000   1.000  1.000
 

12002850 12   Plum                               2.000000   1.000  1.000
 

12002851 12   Plum-babyfood                      2.000000   1.000  1.000
 

12002860 12   Plum, prune, fresh                 2.000000   1.000  1.000
 

12002861 12   Plum, prune, fresh-babyfood        2.000000   1.000  1.000
 

12002870 12   Plum, prune, dried                 2.000000   5.000  1.000
 

12002871 12   Plum, prune, dried-babyfood        2.000000   5.000  1.000
 

12002880 12   Plum, prune, juice                 2.000000   1.400  1.000
 

12002881 12   Plum, prune, juice-babyfood        2.000000   1.400  1.000
 

13010550 13A  Blackberry                        10.000000   1.000  1.000
 

13010560 13A  Blackberry, juice                 10.000000   1.000  1.000
 

13010561 13A  Blackberry, juice-babyfood        10.000000   1.000  1.000
 

13010580 13A  Boysenberry                       10.000000   1.000  1.000
 

13011420 13A  Dewberry                          10.000000   1.000  1.000
 

13012080 13A  Loganberry                        10.000000   1.000  1.000
 

13013200 13A  Raspberry                         10.000000   1.000  1.000
 

13013201 13A  Raspberry-babyfood                10.000000   1.000  1.000
 

13013210 13A  Raspberry, juice                  10.000000   1.000  1.000
 

13013211 13A  Raspberry, juice-babyfood         10.000000   1.000  1.000
 

13020570 13B  Blueberry                          3.000000   1.000  1.000
 

13020571 13B  Blueberry-babyfood                 3.000000   1.000  1.000
 

13021360 13B  Currant                            3.000000   1.000  1.000
 

13021370 13B  Currant, dried                     3.000000   1.000  1.000
 

13021490 13B  Elderberry                         3.000000   1.000  1.000
 

13021740 13B  Gooseberry                         3.000000   1.000  1.000
 

13021910 13B  Huckleberry                        3.000000   1.000  1.000
 

14000030 14   Almond                             0.020000   1.000  1.000
 

14000031 14   Almond-babyfood                    0.020000   1.000  1.000
 

14000040 14   Almond, oil                        0.020000   1.000  1.000
 

14000041 14   Almond, oil-babyfood               0.020000   1.000  1.000
 

14002820 14   Pistachio                          0.100000   1.000  1.000
 

19010280 19A  Basil, fresh leaves                3.000000   1.000  1.000
 

19010281 19A  Basil, fresh leaves-babyfood       3.000000   1.000  1.000
 

19010290 19A  Basil, dried leaves               15.000000   1.000  1.000
 

19010291 19A  Basil, dried leaves-babyfood      15.000000   1.000  1.000
 

19011030 19A  Chive                              3.000000   1.000  1.000
 

19011180 19A  Coriander, leaves                  3.000000   1.000  1.000
 

19011181 19A  Coriander, leaves-babyfood         3.000000   1.000  1.000
 

19011440 19A  Dillweed                           3.000000   1.000  1.000
 

19011840 19A  Herbs, other                       3.000000   1.000  1.000
 

19011841 19A  Herbs, other-babyfood              3.000000   1.000  1.000
 

19012020 19A  Lemongrass                         3.000000   1.000  1.000
 

19012200 19A  Marjoram                           3.000000   1.000  1.000
 

19012201 19A  Marjoram-babyfood                  3.000000   1.000  1.000
 

19012490 19A  Parsley, dried leaves            170.000000   1.000  1.000
 

19012491 19A  Parsley, dried leaves-babyfood   170.000000   1.000  1.000
 

19013340 19A  Savory                             3.000000   1.000  1.000
 

20003190 20   Rapeseed, oil                      0.030000   1.000  1.000
 

20003191 20   Rapeseed, oil-babyfood             0.030000   1.000  1.000
 

21000460 M    Beef, meat byproducts              0.020000   1.000  1.000
 

21000461 M    Beef, meat byproducts-babyfood     0.020000   1.000  1.000
 

21000480 M    Beef, kidney                       0.020000   1.000  1.000
 

21000490 M    Beef, liver                        0.020000   1.000  1.000
 

21000491 M    Beef, liver-babyfood               0.020000   1.000  1.000
 

23001700 M    Goat, meat byproducts              0.020000   1.000  1.000
 

23001720 M    Goat, kidney                       0.020000   1.000  1.000
 

23001730 M    Goat, liver                        0.020000   1.000  1.000
 

26003400 M    Sheep, meat byproducts             0.020000   1.000  1.000
 

26003420 M    Sheep, kidney                      0.020000   1.000  1.000
 

26003430 M    Sheep, liver                       0.020000   1.000  1.000
 

86010000 O    Water, direct, all sources         0.024650   1.000  1.000
 

86020000 O    Water, indirect, all sources       0.024650   1.000  1.000
 

95000200 O    Avocado                            1.200000   1.000  1.000
 

95000740 O    Canistel                           1.200000   1.000  1.000
 

95001750 O    Grape                              0.810000   1.000  1.000
 

95001760 O    Grape, juice                       0.810000   1.200  1.000
 

95001761 O    Grape, juice-babyfood              0.810000   1.200  1.000
 

95001770 O    Grape, leaves                      0.810000   1.000  1.000
 

95001780 O    Grape, raisin                      3.000000   1.000  1.000
 

95001790 O    Grape, wine and sherry             0.810000   1.000  1.000
 

95001950 O    Kiwifruit                          1.800000   1.000  1.000
 

95002090 O    Longan                             2.000000   1.000  1.000
 

95002110 O    Lychee                             2.000000   1.000  1.000
 

95002120 O    Lychee, dried                      2.000000   1.850  1.000
 

95002150 O    Mango                              1.200000   1.000  1.000
 

95002151 O    Mango-babyfood                     1.200000   1.000  1.000
 

95002160 O    Mango, dried                       1.200000   1.000  1.000
 

95002170 O    Mango, juice                       1.200000   1.000  1.000
 

95002171 O    Mango, juice-babyfood              1.200000   1.000  1.000
 

95002450 O    Papaya                             1.200000   1.000  1.000
 

95002451 O    Papaya-babyfood                    1.200000   1.000  1.000
 

95002460 O    Papaya, dried                      1.200000   1.800  1.000
 

95002470 O    Papaya, juice                      1.200000   1.500  1.000
 

95003330 O    Sapote, Mamey                      1.200000   1.000  1.000
 

95003510 O    Spanish lime                       2.000000   1.000  1.000
 

95003590 O    Strawberry                         5.000000   1.000  1.000
 

95003591 O    Strawberry-babyfood                5.000000   1.000  1.000
 

95003600 O    Strawberry, juice                  5.000000   1.000  1.000
 

95003601 O    Strawberry, juice-babyfood         5.000000   1.000  1.000
 

95003980 O    Watercress                        20.000000   1.000  1.000
 

Attachment 3  Results of Acute DEEM-FCID Dietary Exposure Analysis

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for CYPRODINIL                         
(1994-98 data)

Residue file: 288202acuteEPArecommendations.R98       Adjustment factor
#2 used.

Analysis Date: 03-22-2012/07:11:33    Residue file dated:
03-22-2012/07:08:52/8

Daily totals for food and foodform consumption used.

Run Comment: ""

========================================================================
=======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
--------

U.S. Population:

                    0.095794     4.79    0.173478     8.67    0.327751  
 16.39 

All infants:

                    0.102882     5.14    0.372488    18.62    0.943947  
 47.20 

Children 1-2 yrs:

                    0.151445     7.57    0.288151    14.41    0.744868  
 37.24 

Children 3-5 yrs:

                    0.131883     6.59    0.241040    12.05    0.536255  
 26.81 

Children 6-12 yrs:

                    0.098193     4.91    0.167538     8.38    0.358174  
 17.91 

Youth 13-19 yrs:

                    0.080270     4.01    0.160028     8.00    0.212343  
 10.62 

Adults 20-49 yrs:

                    0.092162     4.61    0.172228     8.61    0.309780  
 15.49 

Adults 50+ yrs:

                    0.085400     4.27    0.155374     7.77    0.264973  
 13.25 

Females 13-49 yrs:

                    0.099465     4.97    0.174098     8.70    0.309890  
 15.49

Attachment 4  Results of Chronic DEEM-FCID Dietary Exposure Analysis

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for CYPRODINIL                       (1994-98
data)

Residue file name: C:\Documents and Settings\tmorton\My
Documents\MyFiles\DEEM Files\288202 Cyprodinil\Leafy Petioles 1E7869 and
Misc 1E7854\288202chronicEPArecommendations.R98

                                                     Adjustment factor
#2 used.

Analysis Date 03-22-2012/07:13:12     Residue file dated:
03-22-2012/07:09:53/8

Reference dose (RfD, Chronic) = .027 mg/kg bw/day

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.007421               
27.5%

U.S. Population (spring season)             0.007725               
28.6%

U.S. Population (summer season)             0.007667               
28.4%

U.S. Population (autumn season)             0.007106               
26.3%

U.S. Population (winter season)             0.007194               
26.6%

Northeast region                            0.007971               
29.5%

Midwest region                              0.007167               
26.5%

Southern region                             0.006476               
24.0%

Western region                              0.008696               
32.2%

Hispanics                                   0.007440               
27.6%

Non-hispanic whites                         0.007328               
27.1%

Non-hispanic blacks                         0.006939               
25.7%

Non-hisp/non-white/non-black                0.010253               
38.0%

All infants (< 1 year)                      0.014099               
52.2%

Nursing infants                             0.007361               
27.3%

Non-nursing infants                         0.016657               
61.7%

Children 1-6  yrs                           0.016210               
60.0%

Children 7-12 yrs                           0.008060               
29.9%

Females 13-19 (not preg or nursing)         0.005111               
18.9%

Females 20+ (not preg or nursing)           0.006767               
25.1%

Females 13-50 yrs                           0.006317               
23.4%

Females 13+ (preg/not nursing)              0.006768               
25.1%

Females 13+ (nursing)                       0.007128               
26.4%

Males 13-19 yrs                             0.005276               
19.5%

Males 20+ yrs                               0.005869               
21.7%

Seniors 55+                                 0.007358 
†††††††㜲㌮ഥ䌍楨摬敲⁮ⴱ′特⁳†††††
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摧⮤¨᠀Youth 13-19 yrs                             0.005195         
      19.2%

Adults 20-49 yrs                            0.005818               
21.5%

Adults 50+ yrs                              0.007260               
26.9%

Females 13-49 yrs                           0.006066               
22.5%

------------------------------------------------------------------------
-------

Cyprodinil (PC Code 288202)	Dietary Exposure and Risk Assessment        
         DP # 390233 & 398362:   

Page  PAGE  21  of  NUMPAGES  21