Document ID: EPA-HQ-OPP-2004-0382-0020
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2005-10-06T04:00Z

Thidiazuron
Dietary
Exposure
Assessment
DP
Number:
D321826
PC
Code:
120301
Page:
1
of
10
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
MEMORANDUM
DATE:
9/
26/
2005
SUBJECT:
Thidiazuron:
Chronic
Dietary
Exposure
Assessment
for
the
Reregistration
Eligibility
Decision­
Revised.

PC
Code:
120301
DP
Number:
D321826
FROM:
Toiya
Goodlow,
Chemist
Reregistration
Branch1
Health
Effects
Division
(
7509C)

THROUGH:
Whang
Phang,
Branch
Senior
Scientist
Reregistration
Branch1
Health
Effects
Divison
(
7509C)

TO:
John
Pates,
Chemical
Review
Manager
Special
Review
and
Reregistration
Division
(
7508C)

Executive
Summary
Chronic
dietary
risk
assessments
were
conducted
using
the
Dietary
Exposure
Evaluation
Model
(
DEEM­
FCID
 
)
,
Version
2.0
and
Lifeline
 
Model
Version
3.0,
which
used
food
consumption
data
from
the
United
States
Department
of
Agriculture's
(
USDA's)
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII)
from
1994­
1996
and
1998.
The
analyses
were
performed
to
support
the
reregistration
eligibility
decision.

Chronic
Dietary
Exposure
Results
and
Characterization
A
Tier
I
chronic
dietary
exposure
assessment
was
performed
for
thidiazuron.
The
assumptions
of
these
dietary
exposure
assessments
were
tolerance
level
residues
and
100%
crop
treated,
with
the
Thidiazuron
Dietary
Exposure
Assessment
DP
Number:
D321826
PC
Code:
120301
Page:
2
of
10
exception
of
ruminant
meat,
meat
byproducts,
and
fat
tolerances.
Existing
meat,
meat
byproduct,
and
fat
tolerance
levels
were
not
used
in
the
assessment
because
the
magnitude
of
the
residue
study
for
ruminant
commodities
suggests
higher
residue
values
than
the
current
tolerance
level.
Therefore,
proposed
tolerances
were
used
for
these
commodities.
The
dietary
exposure
analyses
for
thidiazuron
result
in
dietary
risk
estimates
for
food
and
water
that
are
below
the
Agency's
level
of
concern
for
chronic
dietary
exposure.
For
the
chronic
analyses,
the
highest
exposure
and
risk
estimates
were
for
children
1
to
2
years
old.
For
DEEM­
FCID
 
,
the
chronic
exposure
for
children
1
to
2
years
old
was
0.002867
mg/
kg/
day,
which
utilizes
7.3%
of
the
chronic
Population­
Adjusted
Dose
(
cPAD)
for
thidiazuron.
For
the
Lifeline
Model,
the
chronic
exposure
for
children
1
to
2
years
was
old
0.00254
mg/
kg/
day,
which
also
utilizes
6.5%
of
the
cPAD
for
thidiazuron.

I.
Introduction
The
dietary
risk
assessment
incorporates
both
exposure
and
toxicity
of
a
given
pesticide.
For
acute
and
chronic
assessments,
the
risk
is
expressed
as
a
percentage
of
a
maximum
acceptable
dose
(
i.
e.,
the
dose
which
HED
has
concluded
will
result
in
no
unreasonable
adverse
health
effects).
This
dose
is
referred
to
as
the
population
adjusted
dose
(
PAD).
The
PAD
is
equivalent
to
the
reference
dose
(
RfD)
divided
by
the
special
Food
Quality
Protection
Act
(
FQPA)
Safety
Factor.

For
non­
cancer
chronic
exposures,
HED
is
concerned
when
estimated
dietary
risk
exceeds
100%
of
the
PAD.
References
which
discuss
the
chronic
risk
assessments
in
more
detail
are
available
on
the
EPA/
pesticides
web
site:
"
Available
Information
on
Assessing
Exposure
from
Pesticides,
A
User's
Guide,"
6/
21/
2000,
web
link:
http://
www.
epa.
gov/
fedrgstr/
EPA­
PEST/
2000/
July/
Day­
12/
6061.
pdf;
or
see
SOP
99.6
(
8/
20/
99).

This
action
represents
a
revised
version
of
the
dietary
exposure
assessment
dated
May
2,
2005
for
thidiazuron.

II.
Residue
Information
Thidiazuron
Use:

Currently
thidiazuron
tolerances
are
established
for
the
combined
residues
of
thidiazuron
and
its
aniline
containing
metabolites.

CFR
Reference:
40
§
180.403
Commodity
Tolerance
(
ppm)
Cotton,
undelinted
seed
0.4
Meat,
meat
byproducts,
and
fat
0.2
Thidiazuron
Dietary
Exposure
Assessment
DP
Number:
D321826
PC
Code:
120301
Page:
3
of
10
Poultry
meat,
meat
byproducts,
and
fat
0.2
Eggs
0.1
Milk
0.05

Residues
of
Concern
Plant:
Parent
only,
thidiazuron
[
1­
phenyl­
3­(
1,2,3­
thidiazol­
5­
yl)
urea]

Livestock
commodities:
Parent,
thidiazuron
and
metabolites,
4­
hydroxy
thidiazuron
[
1­(
4­
hydrophenyl)­
3­(
1,2,3­
thidiazol­
5­
yl)
urea]
and
phenylurea
Water:
Parent,
thidiazuron
and
photoproducts,
photothidiazuron
[
1­
pheynl­
3­(
1,2,5­
thidiazol­
3­
yl)
urea]
and
1­
cyano­
3­
phenylurea
The
residues
of
concern
for
plant
and
livestock
commodities
were
determined
by
the
HED
Metabolism
Committee
(
9/
29/
95,
F.
Fort).
The
water
residues
of
concern
were
calculated
in
the
Thidiazuron
Drinking
Water
Assessment
provided
by
EFED
(
D244574,
9/
24/
04,
A.
Clem).
Since
the
HED
Metabolism
Assessment
Review
Committee
(
MARC)
did
not
determine
the
residues
of
concern
for
water,
EFED
provided
three
surface
water
exposure
scenarios
for
thidiazuron.
The
most
conservative
of
the
three
scenarios
was
chosen
for
the
dietary
exposure
assessment.

Residue
Data
Used
for
Chronic
Assessments:

Tolerance
level
residues
and
100%
crop
treated
were
used
for
all
commodities
included
in
these
assessments,
with
the
exception
of
ruminant
meat,
meat
byproducts,
and
fat
tolerances.
Adequate
magnitude
of
residue
data
are
not
available
for
ruminant
livestock
commodities.
It
is
tentatively
concluded,
pending
a
storage
stability
and
raw
data
to
validate
the
feeding
study,
that
residues
of
thidiazuron
and
its
metabolites
of
concern
are
not
expected
to
exceed
0.05
ppm
for
milk
and
0.4
ppm
for
meat,
meat
byproducts,
and
fat.
HED
used
these
estimates
in
the
dietary
assessment
from
the
existing
magnitude
of
residue
study
to
obtain
reasonable
high
end
estimates
of
total
thidiazuron
residues
in
ruminant
livestock
commodities.

Poultry
commodities
were
not
included
in
the
dietary
assessment.
Tolerances
are
no
longer
required
for
residues
of
thidiazuron
in/
on
poultry.
The
presently
registered
uses
of
thidiazuron
are
classified
as
Category
3
of
40
CFR
§
180.6(
a)
with
respect
to
the
need
for
tolerances
in
poultry
and
eggs
i.
e.,
there
is
no
reasonable
expectation
of
finite
residues.
No
processing
factors
were
incorporated
into
these
assessments.

Potential
drinking
water
concentrations
for
the
chronic
assessments
were
estimated
using
two
EFED
Tier
1
screening­
level
models:
FIRST,
Version
1.0
and
SCI­
GROW,
Version
2.3.
Since
the
HED
Metabolism
Assessment
Review
Committee
(
MARC)
did
not
determine
the
residues
of
concern
for
water,
EFED
provided
three
estimates
for
possible
drinking
water
concentrations.
Thidiazuron
Dietary
Exposure
Assessment
DP
Number:
D321826
PC
Code:
120301
Page:
4
of
10
The
most
conservative
numbers
were
used
for
the
chronic
assessments,
which
included
thidiazuron
and
both
photoproducts,
photothidiazuron
and
1­
cyano­
3­
phenylurea
in
its
estimate.
The
water
concentration
values
used
was
0.001
ppm
for
the
chronic
assessments.

III
Program
and
Consumption
Information
Several
reasonable
peer­
reviewed
softwares
have
recently
been
emerging
for
modeling
dietary
exposure
to
pesticides.
For
a
variety
of
technical,
historical,
and
availability
reasons,
DEEMTM
was
the
program
generally
used
by
EPA's
Office
of
Pesticide
Programs
(
OPP)
for
conducting
its
dietary
risk
assessments.
With
the
advent
and
current
availability
of
a
number
of
other
exposure
software
programs,
OPP,
registrants,
and
other
interested
parties
have
available
to
them
the
option
of
selecting
other
peer­
reviewed
exposure
software
in
conducting
risk
assessments
for
pestices.
LifelineTM
is
one
such
model
and
is
the
sofware
being
used
in
this
HED
review.
Dietary
exposure
assessments
may
also
be
performed
with
other,
similar
programs,
and
if
submitted,
such
results
will
be
reviewed
by
EPA
for
acceptability
and
comparability
to
existing
peer­
reviewed
software
being
used
by
OPP.

III
a.
DEEM­
FCID
 
Program
and
Consumption
Information
A
thidiazuron
chronic
dietary
exposure
assessment
was
conducted
using
the
Dietary
Exposure
Evaluation
Model
software
with
the
Food
Commodity
Intake
Database
(
DEEM­
FCID
 
,
Version
2.0),
which
incorporates
consumption
data
from
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII),
1994­
1996
and
1998.
The
1994­
96,
98
data
are
based
on
the
reported
consumption
of
more
than
20,000
individuals
over
two
non­
consecutive
survey
days.
Foods
"
as
consumed"
(
e.
g.,
apple
pie)
are
linked
to
EPA­
defined
food
commodities
(
e.
g.
apples,
peeled
fruit
­
cooked;
fresh
or
N/
S;
baked;
or
wheat
flour
­
cooked;
fresh
or
N/
S,
baked)
using
publicly
available
recipe
translation
files
developed
jointly
by
USDA/
ARS
and
EPA.
For
chronic
exposure
assessment,
consumption
data
are
averaged
for
the
entire
U.
S.
population
and
within
population
subgroups,
but
for
acute
exposure
assessment
are
retained
as
individual
consumption
events.
Based
on
analysis
of
the
1994­
96,
98
CSFII
consumption
data,
which
took
into
account
dietary
patterns
and
survey
respondents,
HED
concluded
that
it
is
most
appropriate
to
report
risk
for
the
following
population
subgroups:
the
general
U.
S.
population,
all
infants
(<
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
adults
20­
49,
females
13­
49,
and
adults
50+
years
old.

For
chronic
dietary
exposure
assessment,
an
estimate
of
the
residue
level
in
each
food
or
foodform
(
e.
g.,
orange
or
orange
juice)
on
the
food
commodity
residue
list
is
multiplied
by
the
average
daily
consumption
estimate
for
that
food/
food
form
to
produce
a
residue
intake
estimate.
The
resulting
residue
intake
estimate
for
each
food/
food
form
is
summed
with
the
residue
intake
estimates
for
all
other
food/
food
forms
on
the
commodity
residue
list
to
arrive
at
the
total
average
estimated
exposure.
Exposure
is
expressed
in
mg/
kg
body
weight/
day
and
as
a
percent
of
the
Thidiazuron
Dietary
Exposure
Assessment
DP
Number:
D321826
PC
Code:
120301
Page:
5
of
10
cPAD.
This
procedure
is
performed
for
each
population
subgroup.

III
b.
Lifeline
 
Program
and
Consumption
Information
Chronic
dietary
exposure
estimates
were
also
conducted
using
the
Lifeline
 
model
(
Version
3.0).
These
Lifeline
 
assessments
were
also
conducted
using
the
same
consumption
data
as
the
DEEM­
FCID
 
(
CSFII,
1994­
1996
and
1998
consumption
data
with
FCID).
Lifeline
 
uses
the
recipe
file
to
relate
RACs
to
foods
"
as­
eaten."
Lifeline
 
converts
the
RAC
residues
into
food
residues
by
randomly
selecting
a
RAC
residue
value
from
the
"
user
defined"
residue
distribution
(
created
from
the
residue,
percent
crop
treated,
and
processing
factors
data),
and
calculating
a
net
residue
for
that
food
based
on
the
ingredients'
mass
contribution
to
that
food
item.
For
example,
`
apple
pie'
will
have
a
residue
distribution
based
on
the
residues
provided
for
apples
(
adjusted
by
the
appropriate
processing
factors
and
percent
crop
treated),
as
well
as
the
residues
for
each
of
the
other
ingredients
in
the
apple
pie
recipe
for
which
there
may
be
tolerances.
Lifeline
 
calculates
dietary
exposure
from
`
apple
pie'
based
on
the
amount
eaten,
and
the
residue
drawn
from
the
`
apple
pie'
residue
distribution
for
that
eating
occasion.

Lifeline
 
models
the
individual's
dietary
exposures
over
a
season
by
selecting
a
new
CSFII
diary
each
day
from
a
set
of
similar
individuals
based
on
age
and
season
attributes.
Lifeline
 
groups
CSFII
diaries
based
on
the
respondents'
age
and
the
season
during
which
the
food
diary
was
recorded.
Further
information
regarding
the
Lifeline
 
model
can
be
found
at
the
following
web
site:
www.
theLifeline
 
group.
org.

IV.
Toxicological
Information
Table
I.
Summary
of
Toxicological
Dose
and
Endpoints
for
Dietary
Exposure
Assessment
of
Thidiazuron
Exposure
Scenario
Dose
Used
in
Risk
Assessment,
UF
Hazard
and
Exposure
Based
Special
FQPA
Safety
Factor
Study
and
Toxicological
Effects
Chronic
Dietary
(
All
populations)
NOAEL=
3.93
mg/
kg/
day
UF
=
100
Chronic
RfD
=
0.0393
mg/
kg/
day
FQPA
SF
=
1X
cPAD
=
chronicRfD
FQPA
SF
=
0.0393
mg/
kg/
day
Dog
chronic
toxicity
study
LOAEL
=
11.1
mg/
kg/
day
based
on
increased
incidence
of
anemia,
changes
in
hematological
parameters
and
marked
hemosiderosis
in
liver
and
spleen.

Cancer
Both
rat
and
mouse
carcinogenicity
studies
did
not
show
treatment
related
increase
in
tumor
incidences.
Thidiazuron
Dietary
Exposure
Assessment
DP
Number:
D321826
PC
Code:
120301
Page:
6
of
10
V.
Results/
Discussion
As
stated
above,
for
chronic
assessments,
HED
is
concerned
when
dietary
risk
exceeds
100%
of
the
PAD.
The
DEEM­
FCID
 
analysis
estimates
the
dietary
exposure
of
the
U.
S.
population
and
various
population
subgroups.
The
results
reported
in
Table
II
are
for
the
general
U.
S.
Population,
all
infants
(<
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
females
13­
49,
adults
20­
49,
and
adults
50+
years.

Chronic
dietary
risks
were
also
estimated
using
the
Lifeline
 
model
(
version
3.0).
The
Lifeline
 
chronic
dietary
exposure
estimate
is
based
on
an
average
daily
exposure
from
a
profile
of
1000
individuals
over
a
one
year
period.
Results
of
the
Lifeline
 
analysis
are
fully
consistent
with
DEEM­
FCID
 
results.
The
Lifeline
 
model
estimates
can
also
be
found
in
Table
II.

Results
of
Chronic
Dietary
Exposure
Analysis
The
chronic
assessments
estimate
the
dietary
exposure
of
the
general
U.
S.
population,
all
infants
(<
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
adults
20­
49,
females
13­
49,
and
adults
50+
years
old.
The
highest
exposure
and
risk
estimates
were
for
children
1
to
2
years
old.
For
DEEM­
FCID
 
,
the
chronic
exposure
for
children
1
to
2
years
old
was
0.002867
mg/
kg/
day,
which
utilizes
7.3%
of
the
cPAD
for
thidiazuron.
For
the
Lifeline
Model,
the
chronic
exposure
for
children
1
to
2
years
was
old
0.00254
mg/
kg/
day,
which
also
utilizes
6.5%
of
the
cPAD
for
thidiazuron.
The
results
of
the
chronic
dietary
analyses
for
both
models
are
reported
in
Table
II.

Table
II.
Chronic
Dietary
Exposure
and
Risk
Estimates
for
Thidiazuron­
Food
and
Water
Population
Subgroup
1
PAD,
mg/
kg/
da
y
DEEM­
FCID
Lifeline
Water
Concentration
Estimates
(
ppb)
Exposure,
mg/
kg/
day
%
PAD
2
Exposure,
mg/
kg/
day
%
PAD
2
Chronic
Dietary
Estimates
U.
S.
Population
0.0393
0.000899
2.3
0.000832
2.1
1.0
All
infants
(<
1
yr)
0.0393
0.000928
2.4
0.000809
2.1
1.0
Children
1­
2
yrs
0.0393
0.002867
7.3
0.00254
6.5
1.0
Thidiazuron
Dietary
Exposure
Assessment
DP
Number:
D321826
PC
Code:
120301
Page:
7
of
10
Children
3­
5
yrs
0.0393
0.002252
5.7
0.00219
5.6
1.0
Children
6­
12
yrs
0.0393
0.001482
3.8
0.00139
3.5
1.0
Youth
13­
19
yrs
0.0393
0.000869
2.2
0.000814
2.1
1.0
Adults
20­
49
yrs
0.0393
0.000680
1.7
0.000725
1.9
1.0
Adults
50+
yrs
0.0393
0.000567
1.4
0.000701
1.8
1.0
Females
13­
49
yrs
0.0393
0.000595
1.5
0.000830
2.1
1.0
Cancer
Dietary
Estimate
U.
S.
Population
Toxicological
studies
did
not
indicate
any
cancer
risks
for
thidiazuron,
thus
a
cancer
assessment
was
not
performed.

1
The
values
for
the
population
with
the
highest
risk
for
each
type
of
risk
assessment
are
bolded.
2
Reported
to
1
significant
figure.

VI.
Conclusions
A
Tier
I
dietary
exposure
assessment
was
performed
for
thidiazuron.
The
assumptions
of
these
dietary
exposure
assessments
were
tolerance
level
residues
and
100%
crop
treated,
with
the
exception
of
ruminant
meat,
meat
byproducts
and
fat.
The
dietary­
exposure
analyses
in
this
assessment
for
thidiazon
result
in
dietary
risk
for
food
and
water
estimates
that
are
below
the
Agency's
level
of
concern
for
chronic
dietary
exposure.
The
highest
exposure
and
risk
estimates
were
for
children
1
to
2
years
old.
For
DEEM­
FCID
 
,
the
chronic
exposure
for
children
1
to
2
years
old
was
0.002867
mg/
kg/
day,
which
utilizes
7.3%
of
the
cPAD
for
thidiazuron.
For
the
Lifeline
Model,
the
chronic
exposure
for
children
1
to
2
years
was
old
0.00254
mg/
kg/
day,
which
also
utilizes
6.5%
of
the
cPAD
for
thidiazuron.

As
stated
above,
for
chronic
dietary
exposure
assessments,
HED
is
concerned
when
dietary
risk
exceeds
100%
of
the
PAD.
Both
models
show
that
the
chronic
exposure
is
<
8%
of
the
cPAD
for
thidiazuron.

VII.
References
DP
Barcode
D244574.
Alex
Clem.
September
24,
2004.
Drinking
Water
Assessment
Felecia
A.
Fort.
September
29,
1995.
HED
Metabolism
Committee
Decision
following
the
9/
18/
95
meeting.

MRID
43781901.
DP
Barcode
D220968.
Stephen
Funk.
February
15,
1996.
Thidiazuron:
Thidiazuron
Dietary
Exposure
Assessment
DP
Number:
D321826
PC
Code:
120301
Page:
8
of
10
Response
to
the
Phase
4
Review
Magnitude
of
the
Residue
in
Ruminants.

DP
Barcode
D319302.
Toiya
Goodlow.
August
31,
2005.
Thidiazuron:
Revised
HED
Chapter
of
the
Reregistration
Eligibility
Decision
Document
(
RED),
Phase
3­
Public
Comments.

VIII.
List
of
Attachments
Attachment
1:
DEEM­
FCID
 
Chronic
Food
plus
Water
Residue
Input
file;
Lifeline
available
electronically.
Attachment
2:
Chronic
DEEM­
FCID
 
Results
file;
Lifeline
available
electronically.

cc:
T.
Goodlow/
HED/
RRB1.

Attachment
1:
DEEM­
FCID
 
Chronic
Food
plus
Water
Residue
Input
file.

U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
THIDIAZURON
1994­
98
data
Residue
file:
C:\
2004DEEMFCID\
Thidiazuron\
thidiazuron_
phase3_
food&
H2O.
R98
Adjust.
#
2
NOT
used
Analysis
Date
09­
21­
2005
Residue
file
dated:
08­
29­
2005/
08:
27:
31/
8
Reference
dose
(
RfD)
=
0.0393
(
NOEL)
=
3.93
mg/
kg
bw/
day
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Food
Crop
Residue
Adj.
Factors
Comment
Thidiazuron
Dietary
Exposure
Assessment
DP
Number:
D321826
PC
Code:
120301
Page:
9
of
10
EPA
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
21000440
M
Beef,
meat
0.400000
1.000
1.000
21000441
M
Beef,
meat­
babyfood
0.400000
1.000
1.000
21000450
M
Beef,
meat,
dried
0.400000
1.000
1.000
21000460
M
Beef,
meat
byproducts
0.400000
1.000
1.000
21000461
M
Beef,
meat
byproducts­
babyfood
0.400000
1.000
1.000
21000470
M
Beef,
fat
0.400000
1.000
1.000
21000471
M
Beef,
fat­
babyfood
0.400000
1.000
1.000
21000480
M
Beef,
kidney
0.400000
1.000
1.000
21000490
M
Beef,
liver
0.400000
1.000
1.000
21000491
M
Beef,
liver­
babyfood
0.400000
1.000
1.000
95001280
O
Cottonseed,
oil
0.300000
1.000
1.000
95001281
O
Cottonseed,
oil­
babyfood
0.300000
1.000
1.000
23001690
M
Goat,
meat
0.400000
1.000
1.000
23001700
M
Goat,
meat
byproducts
0.400000
1.000
1.000
23001710
M
Goat,
fat
0.400000
1.000
1.000
23001720
M
Goat,
kidney
0.400000
1.000
1.000
23001730
M
Goat,
liver
0.400000
1.000
1.000
24001890
M
Horse,
meat
0.400000
1.000
1.000
27002220
D
Milk,
fat
0.050000
1.000
1.000
27002221
D
Milk,
fat
­
baby
food/
infant
for
0.050000
1.000
1.000
27012230
D
Milk,
nonfat
solids
0.050000
1.000
1.000
27012231
D
Milk,
nonfat
solids­
baby
food/
in
0.050000
1.000
1.000
27022240
D
Milk,
water
0.050000
1.000
1.000
27022241
D
Milk,
water­
babyfood/
infant
form
0.050000
1.000
1.000
27032251
D
Milk,
sugar
(
lactose)­
baby
food/
0.050000
1.000
1.000
25002900
M
Pork,
meat
0.400000
1.000
1.000
25002901
M
Pork,
meat­
babyfood
0.400000
1.000
1.000
25002910
M
Pork,
skin
0.400000
1.000
1.000
25002920
M
Pork,
meat
byproducts
0.400000
1.000
1.000
25002921
M
Pork,
meat
byproducts­
babyfood
0.400000
1.000
1.000
25002930
M
Pork,
fat
0.400000
1.000
1.000
25002931
M
Pork,
fat­
babyfood
0.400000
1.000
1.000
25002940
M
Pork,
kidney
0.400000
1.000
1.000
25002950
M
Pork,
liver
0.400000
1.000
1.000
26003390
M
Sheep,
meat
0.400000
1.000
1.000
26003391
M
Sheep,
meat­
babyfood
0.400000
1.000
1.000
26003400
M
Sheep,
meat
byproducts
0.400000
1.000
1.000
26003410
M
Sheep,
fat
0.400000
1.000
1.000
26003411
M
Sheep,
fat­
babyfood
0.400000
1.000
1.000
26003420
M
Sheep,
kidney
0.400000
1.000
1.000
26003430
M
Sheep,
liver
0.400000
1.000
1.000
86010000
O
Water,
direct,
all
sources
0.001000
1.000
1.000
86020000
O
Water,
indirect,
all
sources
0.001000
1.000
1.000
Attachment
2:
Chronic
DEEM­
FCID
 
Results
file.

U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
THIDIAZURON
(
1994­
98
data)
Residue
file
name:
C:\
2004DEEMFCID\
Thidiazuron\
thidiazuron_
phase3_
food&
H2O.
R98
Adjustment
factor
#
2
NOT
used.
Analysis
Date
09­
21­
2005/
09:
10:
03
Residue
file
dated:
08­
29­
2005/
08:
27:
31/
8
Reference
dose
(
RfD,
Chronic)
=
.0393
mg/
kg
bw/
day
NOEL
(
Chronic)
=
3.93
mg/
kg
bw/
day
Thidiazuron
Dietary
Exposure
Assessment
DP
Number:
D321826
PC
Code:
120301
Page:
10
of
10
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Margin
of
Percent
Subgroup
body
wt/
day
Exposure
1/
of
RfD
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­­­­
U.
S.
Population
(
total)
0.000899
4,370
2.3%

U.
S.
Population
(
spring
season)
0.000897
4,383
2.3%
U.
S.
Population
(
summer
season)
0.000897
4,383
2.3%
U.
S.
Population
(
autumn
season)
0.000919
4,278
2.3%
U.
S.
Population
(
winter
season)
0.000883
4,450
2.2%

Northeast
region
0.000870
4,515
2.2%
Midwest
region
0.000974
4,036
2.5%
Southern
region
0.000852
4,610
2.2%
Western
region
0.000920
4,274
2.3%

Hispanics
0.001050
3,743
2.7%
Non­
hispanic
whites
0.000856
4,593
2.2%
Non­
hispanic
blacks
0.000973
4,040
2.5%
Non­
hisp/
non­
white/
non­
black
0.001043
3,770
2.7%

All
infants
(<
1
year)
0.000928
4,235
2.4%
Nursing
infants
0.000290
13,568
0.7%
Non­
nursing
infants
0.001170
3,358
3.0%
Children
1­
6
yrs
0.002405
1,634
6.1%
Children
7­
12
yrs
0.001400
2,807
3.6%

Females
13­
19
(
not
preg
or
nursing)
0.000705
5,573
1.8%
Females
20+
(
not
preg
or
nursing)
0.000541
7,270
1.4%
Females
13­
50
yrs
0.000670
5,866
1.7%
Females
13+
(
preg/
not
nursing)
0.000798
4,926
2.0%
Females
13+
(
nursing)
0.000754
5,213
1.9%

Males
13­
19
yrs
0.001025
3,835
2.6%
Males
20+
yrs
0.000739
5,319
1.9%
Seniors
55+
0.000563
6,976
1.4%

Children
1­
2
yrs
0.002867
1,371
7.3%
Children
3­
5
yrs
0.002252
1,745
5.7%
Children
6­
12
yrs
0.001482
2,651
3.8%
Youth
13­
19
yrs
0.000869
4,521
2.2%
Adults
20­
49
yrs
0.000680
5,781
1.7%
Adults
50+
yrs
0.000567
6,928
1.4%
Females
13­
49
yrs
0.000595
6,602
1.5%

­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­