Document ID: EPA-HQ-OPPT-2003-0068-0001
Agency: epa
Document Type: Notice
Title: Fifty-Third Report of the TSCA Interagency Testing Committee (ITC) to the Administrator of the US Environmental Protection Agency
Posted Date: 2004-01-15T05:00Z

Thursday,

January
15,
2004
Part
V
Environmental
Protection
Agency
Fifty­
Third
Report
of
the
TSCA
Interagency
Testing
Committee
to
the
Administrator
of
the
Environmental
Protection
Agency;
Receipt
of
Report
and
Request
for
Comments;
Notice
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69,
No.
10
/
Thursday,
January
15,
2004
/
Notices
ENVIRONMENTAL
PROTECTION
AGENCY
[
OPPT
 
2003
 
0068;
FRL
 
7335
 
2]

Fifty­
Third
Report
of
the
TSCA
Interagency
Testing
Committee
to
the
Administrator
of
the
Environmental
Protection
Agency;
Receipt
of
Report
and
Request
for
Comments
AGENCY:
Environmental
Protection
Agency
(
EPA).
ACTION:
Notice.

SUMMARY:
The
Toxic
Substances
Control
Act
(
TSCA)
Interagency
Testing
Committee
(
ITC)
transmitted
its
Fifty­
Third
Report
to
the
Administrator
of
the
EPA
on
December
2,
2003.
In
the
53rd
ITC
Report,
which
is
included
with
this
notice,
the
ITC
is
revising
the
Priority
Testing
List
by
adding
3
pyridinamines
and
20
tungsten
compounds.
The
ITC
is
requesting
that
EPA
add
the
3
pyridinamines
and
20
tungsten
compounds
to
the
TSCA
section
8(
a)
Preliminary
Assessment
Information
Reporting
(
PAIR)
rule.
In
addition,
the
ITC
is
soliciting
voluntary
use,
exposure,
and
effects
information
for
3
pyridinamines,
20
tungsten
compounds,
and
43
vanadium
compounds
through
its
Voluntary
Information
Submissions
Innovative
Online
Network
(
VISION).
DATES:
Comments,
identified
by
docket
ID
number
OPPT
 
2003
 
0068,
must
be
received
on
or
before
February
17,
2004.
ADDRESSES:
Comments
may
be
submitted
electronically,
by
mail,
or
through
hand
delivery/
courier.
Follow
the
detailed
instructions
as
provided
in
Unit
I.
of
the
SUPPLEMENTARY
INFORMATION.

FOR
FURTHER
INFORMATION
CONTACT:
For
general
information
contact:
Barbara
Cunningham,
Director,
Environmental
Assistance
Division
(
7408M),
Office
of
Pollution
Prevention
and
Toxics,
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460
 
0001;
telephone
number:
(
202)
554
 
1404;
e­
mail
address:
TSCAHotline
epa.
gov.
For
technical
information
contact:
John
D.
Walker,
Director,
TSCA
Interagency
Testing
Committee
(
7401),
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460
 
0001;
telephone
number:
(
202)
564
 
7527;
fax:
(
202)
564
 
7528;
email
address:
walker.
johnd@
epa.
gov.

SUPPLEMENTARY
INFORMATION:

I.
General
Information
A.
Does
this
Action
Apply
to
Me?

This
notice
is
directed
to
the
public
in
general.
It
may,
however,
be
of
particular
interest
to
you
if
you
manufacture
(
defined
by
statute
to
include
import)
and/
or
process
TSCAcovered
chemicals.
Potentially
affected
entities
may
include,
but
are
not
limited
to:
 
Chemical
Industry,
e.
g.,
NAICS
325,
Manufacturers.
 
Petroleum
Industry,
e.
g.,
NAICS
32411,
Refineries.
This
listing
is
not
intended
to
be
exhaustive,
but
rather
provides
a
guide
for
readers
regarding
entities
likely
to
be
affected
by
this
action.
Other
types
of
entities
not
listed
in
this
unit
could
also
be
affected.
The
North
American
Industrial
Classification
System
(
NAICS)
codes
have
been
provided
to
assist
you
and
others
in
determining
whether
this
action
might
apply
to
certain
entities.
If
you
have
any
questions
regarding
the
applicability
of
this
action
to
a
particular
entity,
consult
the
technical
person
listed
under
FOR
FURTHER
INFORMATION
CONTACT.

B.
How
Can
I
Get
Copies
of
this
Document
and
Other
Related
Information?
1.
Docket.
EPA
has
established
an
official
public
docket
for
this
action
under
docket
identification
(
ID)
number
OPPT
 
2003
 
0068.
The
official
public
docket
consists
of
the
documents
specifically
referenced
in
this
action,
any
public
comments
received,
and
other
information
related
to
this
action.
Although
a
part
of
the
official
docket,
the
public
docket
does
not
include
Confidential
Business
Information
(
CBI)
or
other
information
whose
disclosure
is
restricted
by
statute.
The
official
public
docket
is
the
collection
of
materials
that
is
available
for
public
viewing
at
the
EPA
Docket
Center,
Rm.
B102­
Reading
Room,
EPA
West,
1301
Constitution
Ave.,
NW.,
Washington,
DC.
The
EPA
Docket
Center
is
open
from
8:
30
a.
m.
to
4:
30
p.
m.,
Monday
through
Friday,
excluding
legal
holidays.
The
EPA
Docket
Center
Reading
Room
telephone
number
is
(
202)
566
 
1744
and
the
telephone
number
for
the
OPPT
Docket,
which
is
located
in
EPA
Docket
Center,
is
(
202)
566
 
0280.
2.
Electronic
access.
This
Federal
Register
document
may
be
accessed
electronically
through
the
EPA
Internet
under
the
``
Federal
Register''
listings
at
http://
www.
epa.
gov/
fedrgstr/.
You
may
also
access
additional
information
about
the
ITC
at
http://
www.
epa.
gov/
opptintr/
itc/
and
VISION
at
http://
www.
epa.
gov/
opptintr/
itc/
vision.
htm.
An
electronic
version
of
the
public
docket
is
available
through
EPA's
electronic
public
docket
at
http://
www.
epa.
gov/
edocket/.
EPA's
electronic
public
docket
may
be
used
to
submit
or
view
public
comments,
access
the
index
of
the
docket's
contents,
and
to
access
those
documents
in
the
public
docket
that
are
available
electronically.
Although
not
all
docket
materials
may
be
available
electronically,
any
of
the
publicly
available
docket
materials
may
be
accessed
through
the
docket
facility
identified
in
Unit
I.
B.
1.
Once
in
the
system,
select
``
search,''
then
key
in
the
appropriate
docket
ID
number.
Certain
types
of
information
will
not
be
placed
in
the
EPA
Dockets.
Information
claimed
as
CBI
and
other
information
whose
disclosure
is
restricted
by
statute,
which
is
not
included
in
the
official
public
docket,
will
not
be
available
for
public
viewing
in
EPA's
electronic
public
docket.
EPA's
policy
is
that
copyrighted
material
will
not
be
placed
in
EPA's
electronic
public
docket
but
will
be
available
only
in
printed,
paper
form
in
the
official
public
docket.
To
the
extent
feasible,
publicly
available
docket
materials
will
be
made
available
in
EPA's
electronic
public
docket.
When
a
document
is
selected
from
the
index
list
in
EPA
Dockets,
the
system
will
identify
whether
the
document
is
available
for
viewing
in
EPA's
electronic
public
docket.
EPA
intends
to
work
towards
providing
electronic
access
to
all
of
the
publicly
available
docket
materials
through
EPA's
electronic
public
docket.
For
public
commenters,
it
is
important
to
note
that
EPA's
policy
is
that
public
comments,
whether
submitted
electronically
or
in
paper,
will
be
made
available
for
public
viewing
in
EPA's
electronic
public
docket
as
EPA
receives
them
and
without
change,
unless
the
comment
contains
copyrighted
material,
CBI,
or
other
information
whose
disclosure
is
restricted
by
statute.
When
EPA
identifies
a
comment
containing
copyrighted
material,
EPA
will
provide
a
reference
to
that
material
in
the
version
of
the
comment
that
is
placed
in
EPA's
electronic
public
docket.
The
entire
printed
comment,
including
the
copyrighted
material,
will
be
available
in
the
public
docket.
Public
comments
submitted
on
computer
disks
that
are
mailed
or
delivered
to
the
docket
will
be
transferred
to
EPA's
electronic
public
docket.
Public
comments
that
are
mailed
or
delivered
to
the
docket
will
be
scanned
and
placed
in
EPA's
electronic
public
docket.
Where
practical,
physical
objects
will
be
photographed,
and
the
photograph
will
be
placed
in
EPA's
electronic
public
docket
along
with
a
brief
description
written
by
the
docket
staff.

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Vol.
69,
No.
10
/
Thursday,
January
15,
2004
/
Notices
C.
How
and
to
Whom
Do
I
Submit
Comments?

Comments
may
be
submitted
electronically,
by
mail,
or
through
hand
delivery/
courier.
To
ensure
proper
receipt
by
EPA,
identify
the
appropriate
docket
ID
number
in
the
subject
line
on
the
first
page
of
your
comment.
Please
ensure
that
your
comments
are
submitted
within
the
specified
comment
period.
Comments
received
after
the
close
of
the
comment
period
will
be
marked
``
late.''
EPA
is
not
required
to
consider
these
late
comments.
If
you
wish
to
submit
CBI
or
information
that
is
otherwise
protected
by
statute,
please
follow
the
instructions
in
Unit
I.
D.
Do
not
use
EPA
Dockets
or
e­
mail
to
submit
CBI
or
information
protected
by
statute.
1.
Electronically.
If
you
submit
an
electronic
comment
as
prescribed
in
this
unit,
EPA
recommends
that
you
include
your
name,
mailing
address,
and
an
email
address
or
other
contact
information
in
the
body
of
your
comment.
Also
include
this
contact
information
on
the
outside
of
any
disk
or
CD
ROM
you
submit,
and
in
any
cover
letter
accompanying
the
disk
or
CD
ROM.
This
ensures
that
you
can
be
identified
as
the
submitter
of
the
comment
and
allows
EPA
to
contact
you
in
case
EPA
cannot
read
your
comment
due
to
technical
difficulties
or
needs
further
information
on
the
substance
of
your
comment.
EPA's
policy
is
that
EPA
will
not
edit
your
comment,
and
any
identifying
or
contact
information
provided
in
the
body
of
a
comment
will
be
included
as
part
of
the
comment
that
is
placed
in
the
official
public
docket,
and
made
available
in
EPA's
electronic
public
docket.
If
EPA
cannot
read
your
comment
due
to
technical
difficulties
and
cannot
contact
you
for
clarification,
EPA
may
not
be
able
to
consider
your
comment.
i.
EPA
Dockets.
Your
use
of
EPA's
electronic
public
docket
to
submit
comments
to
EPA
electronically
is
EPA's
preferred
method
for
receiving
comments.
Go
directly
to
EPA
Dockets
at
http://
www.
epa.
gov/
edocket/,
and
follow
the
online
instructions
for
submitting
comments.
Once
in
the
system,
select
``
search,''
and
then
key
in
docket
ID
number
OPPT
 
2003
 
0068.
The
system
is
an
``
anonymous
access''
system,
which
means
EPA
will
not
know
your
identity,
e­
mail
address,
or
other
contact
information
unless
you
provide
it
in
the
body
of
your
comment.
ii.
E­
mail.
Comments
may
be
sent
by
e­
mail
to
oppt.
ncic@
epa.
gov,
Attention:
Docket
ID
Number
OPPT
 
2003
 
0068.
In
contrast
to
EPA's
electronic
public
docket,
EPA's
e­
mail
system
is
not
an
``
anonymous
access''
system.
If
you
send
an
e­
mail
comment
directly
to
the
docket
without
going
through
EPA's
electronic
public
docket,
EPA's
e­
mail
system
automatically
captures
your
email
address.
E­
mail
addresses
that
are
automatically
captured
by
EPA's
e­
mail
system
are
included
as
part
of
the
comment
that
is
placed
in
the
official
public
docket,
and
made
available
in
EPA's
electronic
public
docket.
iii.
Disk
or
CD
ROM.
You
may
submit
comments
on
a
disk
or
CD
ROM
that
you
mail
to
the
mailing
address
identified
in
Unit
I.
C.
2.
These
electronic
submissions
will
be
accepted
in
WordPerfect
or
ASCII
file
format.
Avoid
the
use
of
special
characters
and
any
form
of
encryption.
2.
By
mail.
Send
your
comments
to:
Document
Control
Office
(
7407M),
Office
of
Pollution
Prevention
and
Toxics
(
OPPT),
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460
 
0001.
3.
By
hand
delivery
or
courier.
Deliver
your
comments
to:
OPPT
Document
Control
Office
(
DCO),
EPA
East
Bldg.,
Rm.
6428,
1201
Constitution
Ave.,
NW.,
Washington,
DC.
Attention:
Docket
ID
Number
OPPT
 
2003
 
0068.
The
DCO
is
open
from
8
a.
m.
to
4
p.
m.,
Monday
through
Friday,
excluding
legal
holidays.
The
telephone
number
for
the
DCO
is
(
202)
564
 
8930.

D.
How
Should
I
Submit
CBI
to
the
Agency?
Do
not
submit
information
that
you
consider
to
be
CBI
electronically
through
EPA's
electronic
public
docket
or
by
e­
mail.
You
may
claim
information
that
you
submit
to
EPA
as
CBI
by
marking
any
part
or
all
of
that
information
as
CBI
(
if
you
submit
CBI
on
disk
or
CD
ROM,
mark
the
outside
of
the
disk
or
CD
ROM
as
CBI
and
then
identify
electronically
within
the
disk
or
CD
ROM
the
specific
information
that
is
CBI).
Information
so
marked
will
not
be
disclosed
except
in
accordance
with
procedures
set
forth
in
40
CFR
part
2.
In
addition
to
one
complete
version
of
the
comment
that
includes
any
information
claimed
as
CBI,
a
copy
of
the
comment
that
does
not
contain
the
information
claimed
as
CBI
must
be
submitted
for
inclusion
in
the
public
docket
and
EPA's
electronic
public
docket.
If
you
submit
the
copy
that
does
not
contain
CBI
on
disk
or
CD
ROM,
mark
the
outside
of
the
disk
or
CD
ROM
clearly
that
it
does
not
contain
CBI.
Information
not
marked
as
CBI
will
be
included
in
the
public
docket
and
EPA's
electronic
public
docket
without
prior
notice.
If
you
have
any
questions
about
CBI
or
the
procedures
for
claiming
CBI,
please
consult
the
technical
person
listed
under
FOR
FURTHER
INFORMATION
CONTACT.

E.
What
Should
I
Consider
as
I
Prepare
My
Comments
for
EPA?

We
invite
you
to
provide
your
views
and
comments
on
the
53rd
ITC
Report.
You
may
find
the
following
suggestions
helpful
for
preparing
your
comments:
1.
Explain
your
views
as
clearly
as
possible.
2.
Describe
any
assumptions
that
you
used.
3.
Provide
copies
of
any
technical
information
and/
or
data
you
used
that
support
your
views.
4.
Provide
specific
examples
to
illustrate
your
concerns.
5.
Make
sure
to
submit
your
comments
by
the
deadline
in
this
notice.
6.
To
ensure
proper
receipt
by
EPA,
be
sure
to
identify
the
docket
ID
number
assigned
to
this
action
in
the
subject
line
on
the
first
page
of
your
response.
You
may
also
provide
the
name,
date,
and
Federal
Register
citation.

II.
Background
The
Toxic
Substances
Control
Act
(
TSCA)
(
15
U.
S.
C.
260let
seq.)
authorizes
the
Administrator
of
the
EPA
to
promulgate
regulations
under
section
4(
a)
requiring
testing
of
chemicals
and
chemical
mixtures
in
order
to
develop
data
relevant
to
determining
the
risks
that
such
chemicals
and
chemical
mixtures
may
present
to
health
or
the
environment.
Section
4(
e)
of
TSCA
established
the
ITC
to
recommend
chemicals
and
chemical
mixtures
to
the
Administrator
of
the
EPA
for
priority
testing
consideration.
Section
4(
e)
of
TSCA
directs
the
ITC
to
revise
the
TSCA
section
4(
e)
Priority
Testing
List
at
least
every
6
months.

A.
The
ITC's
53rd
Report
The
53rd
ITC
Report
was
transmitted
to
the
EPA's
Administrator
on
December
2,
2003,
and
is
included
in
this
notice.
In
the
53rd
ITC
Report,
the
ITC
revises
the
Priority
Testing
List
by
adding
3
pyridinamines
and
20
tungsten
compounds,
requests
that
EPA
add
the
pyridinamines
and
tungsten
compounds
to
the
TSCA
section
8(
a)
PAIR
rule
and
solicits
voluntary
use,
exposure,
and
effects
information
for
pyridinamines,
tungsten
compounds,
and
vanadium
compounds.

B.
Status
of
the
Priority
Testing
List
The
current
TSCA
4(
e)
Priority
Testing
List
as
of
November
2003
can
be
found
in
Table
1
of
the
53rd
ITC
Report,
which
is
included
in
this
notice.

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Notices
List
of
Subjects
Environmental
protection,
Chemicals,
Hazardous
substances.

Dated:
January
8,
2004.
Charles
M.
Auer,
Director,
Office
of
Pollution
Prevention
and
Toxics.

Fifty­
Third
Report
of
the
TSCA
Interagency
Testing
Committee
to
the
Administrator,
U.
S.
Environmental
Protection
Agency
Table
of
Contents
Summary
The
TSCA
Section
4(
e)
Priority
Testing
List
I.
Background
II.
TSCA
Section
8
Reporting
A.
TSCA
Section
8
Reporting
Rules
B.
ITC's
Use
of
TSCA
Section
8
and
Other
Information
C.
New
Requests
to
Add
Chemicals
to
the
TSCA
Section
8(
a)
PAIR
Rule
D.
Previous
Requests
to
Add
Chemicals
to
the
TSCA
Section
8(
d)
HaSDR
Rule
III.
ITC's
Activities
During
this
Reporting
Period
(
May
to
November
2003)
IV.
Revisions
to
the
TSCA
Section
4(
e)
Priority
Testing
List
V.
References
VI.
The
TSCA
Interagency
Testing
Committee
Summary
In
this
53rd
Report,
the
ITC
is
revising
the
Priority
Testing
List
by
adding
3
pyridinamines
and
20
tungsten
compounds.
The
ITC
is
requesting
that
EPA
add
the
3
pyridinamines
and
20
tungsten
compounds
to
the
TSCA
section
8(
a)
Preliminary
Assessment
Information
Reporting
(
PAIR)
rule.
The
TSCA
section
4(
e)
Priority
Testing
List
follows
as
Table
1
of
this
unit.

TABLE
1.
 
THE
TSCA
SECTION
4(
E)
PRIORITY
TESTING
LIST
(
NOVEMBER
2003)

ITC
Report
Date
Chemical
name/
Group
Action
31
January
1993
13
Chemicals
with
insufficient
dermal
absorption
rate
data
Designated
32
May
1993
16
Chemicals
with
insufficient
dermal
absorption
rate
data
Designated
35
November
1994
4
Chemicals
with
insufficient
dermal
absorption
rate
data
Designated
37
November
1995
4­
tert­
Butylphenol
and
Branched
nonylphenol
(
mixed
isomers)
Recommended
41
November
1997
Phenol,
4­(
1,1,3,3­
tetramethylbutyl)­
Recommended
42
May
1998
3­
Amino­
5­
mercapto­
1,2,4­
triazole
Recommended
42
May
1998
Glycoluril
Recommended
47
November
2000
9
Indium
compounds
Recommended
48
May
2001
Benzenamine,
3­
chloro­
2,6­
dinitro­
N,
N­
dipropyl­
4­
(
trifluoromethyl)­
Recommended
49
November
2001
Stannane,
dimethylbis[(
1­
oxoneodecyl)
oxy]­
Recommended
50
May
2002
Benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
Recommended
50
May
2002
1­
Triazene,
1,3­
diphenyl­
Recommended
51
November
2002
43
Vanadium
compounds
Recommended
53
November
2003
3
Pyridinamines
Recommended
53
November
2003
20
Tungsten
compounds
Recommended
I.
Background
The
ITC
was
established
by
section
4(
e)
of
the
Toxic
Substances
Control
Act
(
TSCA)
``
to
make
recommendations
to
the
Administrator
respecting
the
chemical
substances
and
mixtures
to
which
the
Administrator
should
give
priority
consideration
for
the
promulgation
of
rules
for
testing
under
section
4(
a)....
At
least
every
six
months
...,
the
Committee
shall
make
such
revisions
to
the
Priority
Testing
List
as
it
determines
to
be
necessary
and
transmit
them
to
the
Administrator
together
with
the
Committee's
reasons
for
the
revisions''
(
Public
Law
94
 
469,
90
Stat.
2003
et
seq.,
15
U.
S.
C.
2601
et
seq.).
ITC
Reports
are
available
from
the
ITC's
web
site
(
http://
www.
epa.
gov/
opptintr/
itc)
within
a
few
days
of
submission
to
the
Administrator
and
from
the
EPA's
web
site
http://
www.
epa.
gov/
fedrgstr/
after
publication
in
the
Federal
Register.
The
ITC
produces
its
revisions
to
the
Priority
Testing
List
with
administrative
and
technical
support
from
the
ITC
Staff,
ITC
Members
and
their
U.
S.
Government
organizations,
and
contract
support
provided
by
EPA.
ITC
Members
and
Staff
are
listed
at
the
end
of
this
report.

II.
TSCA
Section
8
Reporting
A.
TSCA
Section
8
Reporting
Rules
Following
receipt
of
the
ITC's
Report
(
and
the
revised
Priority
Testing
List)
by
the
EPA
Administrator,
the
EPA's
Office
of
Pollution
Prevention
and
Toxics
(
OPPT)
adds
the
chemicals
from
the
revised
Priority
Testing
List
to
the
TSCA
section
8(
a)
PAIR
and
TSCA
section
8(
d)
Health
and
Safety
Data
Reporting
(
HaSDR)
rules.
The
PAIR
rule
requires
producers
and
importers
of
Chemical
Abstract
Service
(
CAS)­
numbered
chemicals
added
to
the
Priority
Testing
List
to
submit
production
and
exposure
reports
(
http://
www.
epa.
gov/
opptintr/
chemtest/
pairform.
pdf).
The
HaSDR
rule
requires
producers,
importers,
and
processors
of
all
chemicals
added
to
the
Priority
Testing
List
to
submit
unpublished
health
and
safety
studies
under
TSCA
section
8(
d)
that
must
be
in
compliance
with
the
revised
HaSDR
rule
(
Ref.
1).
All
submissions
must
be
received
by
the
EPA
within
90
days
of
the
reporting
rules
Federal
Register
publication
date.

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B.
ITC's
Use
of
TSCA
Section
8
and
Other
Information
The
ITC's
use
of
TSCA
section
8
and
other
information
is
described
in
previous
ITC
Reports
(
http://
www.
epa.
gov/
opptintr/
itc/
rptmain.
htm).

C.
New
Requests
to
Add
Chemicals
to
the
TSCA
Section
8(
a)
PAIR
Rule
The
ITC
is
requesting
that
EPA
add
3
pyridinamines
and
20
tungsten
compounds
to
the
TSCA
section
8(
a)
PAIR
rule.
The
3
pyridinamines
and
20
tungsten
compounds
are
discussed
in
Units
IV.
A.
1.
and
IV.
A.
2.
of
this
report.

D.
Previous
Requests
to
Add
Chemicals
to
the
TSCA
Section
8(
d)
HaSDR
Rule
In
previous
ITC
Reports
it
was
requested
that
the
following
chemicals
be
added
to
the
TSCA
section
8(
d)
HaSDR
rule:
3H­
1,2,4­
triazole­
3­
thione,
5­
amino­
1,2­
dihydro­
(
3­
amino­
5­
mercapto­
1,2,4­
triazole)
(
CAS
No.
16691
 
43
 
3)
and
imidazo[
4,5­
d]
imidazole­
2,5(
1H,
3H)­
dione,
tetrahydro­
(
glycoluril)
(
CAS
No.
496
 
46
 
8)
(
42nd
ITC
Report,
Ref.
2),
9
indium
compounds
(
47th
ITC
Report,
Ref.
3);
benzenamine,
3­
chloro­
2,
6­
dinitro­
N,
N­
dipropyl­
4­(
trifluoromethyl)­
(
CAS
No.
29091
 
20
 
1)
(
48th
ITC
Report,
Ref
4);
and
stannane,
dimethylbis[(
1­
oxoneodecyl)
oxy]­
(
CAS
No.
68928
 
76
 
7),
benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
(
CAS
No.
3278
 
89
 
5)
and
1­
triazene,
1,3­
diphenyl­
(
CAS
No.
136
 
35
 
6)
(
50th
ITC
Report,
Ref.
5).
The
TSCA
section
8(
d)
studies
requested
for
these
chemicals
were
listed
in
the
ITC's
51st
Report
(
Ref.
6).

III.
ITC's
Activities
During
this
Reporting
Period
(
May
to
November
2003)

During
this
reporting
period,
the
ITC
received
voluntary
information
submissions
from
the
Color
Pigments
Manufacturers
Association
(
CPMA)
and
the
Vanadium
Producers
and
Reclaimers
Association
(
VPRA)
in
response
to
solicitations
for
the
43
vanadium
compounds
listed
in
the
ITC's
51st
Report
(
Ref.
6).
The
procedures
for
submitting
voluntary
information
through
the
ITC's
Voluntary
Information
Submissions
Innovative
Online
Network
(
VISION)
are
described
on
the
ITC's
web
site
(
http://
www.
epa.
gov/
opptintr/
itc/
vision.
htm).
During
this
reporting
period,
the
ITC
reviewed
the
PAIR
reports
submitted
in
response
to
the
June
11,
2003,
PAIR
rule
(
Ref.
7).
This
PAIR
rule
required
submission
of
reports
for
benzenamine,
3­
chloro­
2,6­
dinitro­
N,
N­
dipropyl­
4­(
trifluoromethyl)­
(
CAS
No.
29091
 
20­
1);
stannane,
dimethylbis[(
1­
oxoneodecyl)
oxy]­
(
CAS
No.
68928
 
76
 
7);
benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
(
CAS
No.
3278
 
89
 
5);
and
1­
triazene,
1,3­
diphenyl­
(
CAS
No.
136
 
35
 
6
)
and
the
43
vanadium
compounds
listed
in
the
ITC's
51st
Report.
The
ITC
is
continuing
to
analyze
the
data
in
those
reports
as
well
as
data
submitted
voluntarily.
For
the
43
vanadium
compounds
listed
in
the
ITC's
51st
Report
(
Ref.
6),
the
ITC
is
still
soliciting
voluntary
submissions
of:
1.
Recent
non­
CBI
estimates
of
annual
production
or
importation
volume
data
and
trends,
and
use
information,
including
percentages
of
production
or
importation
that
are
associated
with
different
uses.
2.
Estimates
of
the
number
of
humans
and
concentrations
of
vanadium
compounds
to
which
humans
may
be
exposed
during
manufacturing
or
processing.
3.
Health
effects
data
including
pharmacokinetics,
genotoxicity,
subchronic
toxicity,
reproductive
and
developmental
toxicity,
and
any
human
data
from
occupationally
exposed
workers.
The
ITC
is
soliciting
this
information
in
order
to
adequately
assess
the
extent
and
degree
of
exposure
and
potential
hazard
associated
with
the
various
forms
of
vanadium.
In
addition,
the
ITC
is
soliciting
voluntary
information
submissions
for
the
3
pyridinamines
and
20
tungsten
compounds
being
added
to
the
Priority
Testing
List
to
meet
U.
S.
Government
data
needs.
The
information
being
solicited
is
summarized
in
Unit
IV.
A.
1.
c.
and
IV.
A.
2.
c.
of
this
report.

IV.
Revisions
to
the
TSCA
Section
4(
e)
Priority
Testing
List
A.
Chemicals
Added
to
the
Priority
Testing
List
1.
Pyridinamines
 
a.
Recommendation.
Pyridinamines
are
being
added
to
the
Priority
Testing
List
to
obtain
importation,
production,
use,
exposure,
and
health
effects
information
to
meet
U.
S.
Government
data
needs.
Three
pyridinamines
are
being
recommended:
2­
Pyridinamine
(
CAS
No.
504
 
29
 
0),
3­
pyridinamine
(
CAS
No.
462
 
08
 
8)
and
4­
pyridinamine
(
CAS
No.
504
 
24
 
5).
b.
Rationale
for
recommendation.
Pyridinamines
are
readily
absorbed
through
the
skin
and
the
gastrointestinal
tract
and
widely
distributed
in
the
body,
including
the
brain.
They
are
not
metabolized
and
are
completely
excreted
through
the
kidneys.
Studies
in
animals
and
humans
have
shown
that
pyridinamines
are
acutely
toxic
compounds.
Part
of
this
toxic
response
may
be
due
to
their
ability
to
block
K+
channels
causing,
among
other
effects,
convulsions.
The
chronic
toxicity
of
these
compounds
has
not
received
adequate
evaluation.
To
determine
a
priority
for
testing
members
of
the
pyridinamine
class
of
compounds,
additional
information
is
needed
to
characterize
human
exposure
potential.
c.
Information
needs.
For
each
individual
pyridinamine:
Recent
data
or
estimates
of
annual
production
and
importation
volume
and
trends;
information
on
specific
uses,
including
percentages
of
production
or
importation
volume
associated
with
each
of
these
uses;
estimates
of
the
number
of
persons
potentially
exposed
to
each
pyridinamine
during
its
manufacture
and
use
and
health
effects,
including
chronic
toxicity
data.
d.
Supporting
information.
Pyridinamines
are
chemicals
in
commerce.
The
annual
production
volume
of
2­
pyridinamine
exceeded
1
million
pounds
in
1998;
it
is
used
in
hair
colorants
and
as
an
intermediate
in
the
manufacture
of
pharmaceuticals.
3­
Pyridinamine
is
an
intermediate
in
the
production
of
agrochemicals
and
pharmaceuticals;
it
may
have
end­
uses.
In
addition
to
its
use
as
a
chemical
intermediate,
4­
pyridinamine
is
the
active
ingredient
in
the
registered
pesticide
Avitrol
 
and
has
been
evaluated
as
an
experimental
drug
to
treat
several
neurological
syndromes.
Under
the
Food
and
Drug
Administration
(
FDA)
Modernization
Act
of
1997
(
http://
www.
fda.
gov/
opacom/
7modact.
html),
4­
pyridinamine
was
nominated
for
inclusion
on
the
list
of
bulk
substances
for
use
in
pharmacy
compounding
but
was
not
included
by
the
FDA
on
the
initial
list.
Human
exposure
data
are
limited
for
pyridinamines.
A
survey
conducted
between
1981
and
1983
by
the
National
Institute
for
Occupational
Safety
and
Health
estimated
that
4,618
workers
in
452
facilities
representing
3
industries
were
potentially
exposed
to
4­
pyridinamine.
2.
Tungsten
compounds
 
a.
Recommendation.
Twenty
tungsten
compounds
are
being
added
to
the
Priority
Testing
List
to
obtain
importation,
production,
use,
exposure,
and
health
effects
information
to
meet
U.
S.
Government
data
needs
(
Table
2).
The
ITC
believes
the
list
of
tungsten
compounds
in
Table
2
includes
those
most
likely
to
be
in
current
use.

TABLE
2.
 
TUNGSTEN
COMPOUNDS
BEING
ADDED
TO
THE
TSCA
SECTION
8(
A)
PAIR
RULE
CAS
No.
Chemical
name
1314
 
35
 
8
Tungsten
oxide
(
WO3)

7440
 
33
 
7
Tungsten
7783
 
82
 
6
Tungsten
fluoride
(
WF6),
(
OC
 
6
 
11)­

7790
 
85
 
4
Cadmium
tungsten
oxide
(
CdWO4)

7790
 
60
 
5
Tungstate
(
WO4
2­),
dipotassium,
(
T­
4)­

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TABLE
2.
 
TUNGSTEN
COMPOUNDS
BEING
ADDED
TO
THE
TSCA
SECTION
8(
A)
PAIR
RULE
 
Continued
CAS
No.
Chemical
name
7783
 
03
 
1
Tungstate
(
WO4
2­),
dihydrogen,
(
T­
4)­

10213
 
10
 
2
Tungstate
(
WO4
2­),
disodium,
dihydrate,
(
T­
4)­

11105
 
11
 
6
Tungsten
oxide
(
WO3),
hydrate
11120
 
01
 
7
Sodium
tungsten
oxide
11120
 
25
 
5
Tungstate
(
W12(
OH)
2
O40
10­),
decaammonium
12067
 
99
 
1
Tungsten
hydroxide
oxide
phosphate
12028
 
48
 
7
Tungstate
(
W12(
OH)
2
O38
6­),
hexaammonium
12027
 
38
 
2
Tungstate(
4­),[.
mu.
12­[
orthosilicato(
4­)­
.
kappa.
O:.
kappa.
O:.
kappa.
O:.
kappa.
O':.
kappa.
O':.
kappa.
O':.
kappa.
O''.
kappa.
O'':.
kappa.
O''
:.
kappa.
O''':
kappa.
O''':.
kappa.
O''']]
tetracosa­.
mu.­
oxododecaoxododeca­,
tetrahydrogen
12036
 
22
 
5
Tungsten
oxide
(
WO2)

12141
 
67
 
2
Tungstate
(
W12(
OH)
2
O38
6­),
hexasodium
12138
 
09
 
9
Tungsten
sulfide
(
WS2)

13283
 
01
 
7
Tungsten
chloride
(
WCl6),
(
OC
 
6
 
11)­

13472
 
45
 
2
Tungstate
(
WO4
2­),
disodium,
(
T­
4)­

14040
 
11
 
0
Tungsten
carbonyl
(
W(
CO)
6),
(
OC
 
6
 
11)­

23321
 
70
 
2
Tungsten
oxide
(
WO3),
dihydrate
b.
Rationale
for
recommendation.
Tungsten
was
recently
nominated
for
toxicology
and
carcinogenicity
studies
to
the
National
Toxicology
Program
by
the
Centers
for
Disease
Control
and
Prevention's
National
Center
for
Environmental
Health
(
http://
ntpserver
niehs.
nih.
gov/
NomPage/
2003Noms.
html).
The
nomination
was
based
on
recent
data
showing
elevated
tungsten
body
burdens
in
residents
of
Fallon,
NV,
and
the
limited
data
available
to
assess
the
potential
long­
term
adverse
health
effects
of
tungsten
exposure
(
http://
www.
cdc.
gov/
nceh/
clusters/
Fallon).
The
source
and
pathways
of
exposure,
and
the
form
of
tungsten
to
which
Fallon,
NV,
residents
are
exposed
is
presently
poorly
understood.
The
Agency
for
Toxic
Substances
and
Disease
Registry
(
ATSDR)
has
completed
community
exposure
and
health
investigations
in
Churchill
County,
NV
(
http://
www.
atsdr.
cdc.
gov/
HAC/
PHA/
region_
9.
html#
nevada)
and
is
developing
a
toxicological
profile
for
tungsten
(
http://
www.
atsdr.
cdc.
gov/
toxprofiles/
tp186.
html).
Tungsten
and
tungsten
compounds
have
numerous
important
industrial
uses.
Other
than
workplace
exposure
limits,
there
are
few
regulatory
controls
on
the
use,
emission,
and
disposal
of
tungsten
compounds
and
few
data
on
which
to
assess
the
ecological
effects
and
human
health
impacts
resulting
from
environmental
and
general
population
exposures.
Further
information
is
needed
to
more
fully
evaluate
human
and
environmental
exposures
and
health
effects.
c.
Information
needs.
To
meet
U.
S.
Government
data
needs,
the
ITC
needs:
1.
Recent
non­
CBI
estimates
of
annual
production
or
importation
volume
data
and
trends,
and
chemical­
specific
use
information,
including
percentages
of
production
or
importation
that
are
associated
with
different
uses.
2.
Environmental
release
and
monitoring
information,
including
occurrence
and
concentrations
in
environmental
media.
3.
Fate
and
transport
data.
4.
Ecological
effects
data,
especially
for
aquatic
and
sediment
organisms,
if
there
is
evidence
that
tungsten
compounds
are
mobilized
and
transported
to
groundwater,
surface
water,
and
sediments.
5.
Estimates
of
the
number
of
exposed
humans
and
concentrations
of
tungsten
compounds
to
which
humans
may
be
exposed
in
each
relevant
manufacturing,
processing,
or
other
occupational
scenario.
6.
Case
studies
from
occupationally
exposed
workers
and
pharmacokinetics,
dermal,
inhalation,
and
oral
acute
toxicity,
subchronic
toxicity,
chronic
toxicity,
genotoxicity,
carcinogenicity,
neurotoxicity,
reproductive
and
developmental
toxicity,
and
epidemiology
studies.
The
ITC
is
soliciting
this
information
in
order
to
adequately
assess
the
extent
and
degree
of
exposure
and
potential
hazard
associated
with
the
various
forms
of
tungsten
and
to
determine
if
additional
test
data
are
needed.
d.
Supporting
information.
Tungsten
compounds
are
naturally
released
to
the
atmosphere
by
windblown
dusts.
Tungsten
compounds
can
be
released
to
surface
waters
from
sources
of
human
origin
(
e.
g.,
water
effluents
from
tungsten
mining).
Deposition
of
tungsten
aerosols
or
dusts
from
both
natural
and
anthropogenic
sources
is
also
a
source
of
tungsten
in
surface
waters.
Individuals
who
work
in
manufacturing,
fabricating,
and
reclaiming
industries,
especially
individuals
using
hard­
metal
materials
or
tungsten
carbide
machining
tools,
may
be
exposed
to
higher
levels
of
tungsten
compounds
than
the
general
population.
Occupational
exposure
is
primarily
via
inhalation
of
dust
particles
of
elemental
(
metallic)
tungsten
and/
or
its
compounds.
Pulmonary
fibrosis,
memory
and
sensory
deficits,
and
increased
mortality
due
to
lung
cancer
have
been
associated
with
occupational
exposure
to
dusts
generated
in
the
hard­
metal
industry.
Historically,
the
respiratory
and
neurological
effects
observed
in
hard­
metal
workers
have
been
attributed
to
cobalt,
not
tungsten.
However,
based
on
the
presence
of
tungsten
oxide
fibers
in
air
samples
taken
at
some
hard­
metal
facilities
and
demonstrations
that
tungsten
oxide
fibers
are
capable
of
generating
hydroxyl
radicals
in
human
lung
cells
in
vitro,
it
has
been
suggested
that
tungsten
oxide
fibers
may
contribute
to
the
development
of
pulmonary
fibrosis
in
hard­
metal
workers.
Limited
reports
associate
tungsten
exposure
with
reproductive
and
developmental
effects
such
as
decreased
sperm
motility,
increased
embryotoxicity,
and
delayed
fetal
skeletal
ossification
in
animals.
Tungsten
has
been
observed
to
cross
the
placental
barrier
and
enter
the
fetus.
Dermal
or
ocular
exposure
to
tungsten
may
result
in
localized
irritation.

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Federal
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/
Vol.
69,
No.
10
/
Thursday,
January
15,
2004
/
Notices
V.
References
1.
EPA.
1998.
Revisions
to
Reporting
Regulations
Under
TSCA
Section
8(
d)
Federal
Register
(
63
FR
15765,
April
1,
1998)
(
FRL
 
5750
 
4).
Available
online
at:
http://
www.
epa.
gov/
fedrgstr/.
2.
ITC.
1998.
Forty­
Second
Report
of
the
ITC.
Federal
Register
(
63
FR
42554,
August
7,
1998)
(
FRL
 
5797
 
8).
Available
online
at:
http://
www.
epa.
gov/
fedrgstr/.
3.
ITC.
2001.
Forty­
Seven
Report
of
the
ITC.
Federal
Register
(
66
FR
17768
April
3,
2001)
(
FRL
 
6763
 
6).
Available
online
at:
http://
www.
epa.
gov/
fedrgstr/.
4.
ITC.
2001.
Forty­
Eighth
Report
of
the
ITC.
Federal
Register
(
66
FR
51276,
October
5,
2001)
(
FRL
 
6786
 
7).
Available
online
at:
http://
www.
epa.
gov/
fedrgstr/.
5.
ITC.
2002.
Fiftieth
Report
of
the
ITC.
Federal
Register
(
67
FR
49530,
July
30,
2002)
(
FRL
 
7183
 
7).
Available
online
at:
http://
www.
epa.
gov/
fedrgstr/.
6.
ITC.
2002.
Fifty­
First
Report
of
the
ITC.
Federal
Register
(
68
FR
8976,
February
26,
2003)
(
FRL
 
7285
 
7).
Available
online
at:
http://
www.
epa.
gov/
fedrgstr/.
7.
EPA.
2003.
Preliminary
Assessment
Information
Reporting;
Addition
of
Certain
Chemicals.
Federal
Register
(
68
FR
34832,
June
11,
2003)
(
FRL
 
7306
 
7).
Available
online
at:
http://
www.
epa.
gov/
fedrgstr/.

VI.
The
TSCA
Interagency
Testing
Committee
Statutory
Organizations
and
Their
Representatives
Council
on
Environmental
Quality
Vacant
Department
of
Commerce
National
Institute
of
Standards
and
Technology
Robert
Huie,
Member
Barbara
C.
Levin,
Alternate
National
Oceanographic
and
Atmospheric
Administration
Thomas
P.
O'Connor,
Member,
Vice
Chair
Teri
Rowles,
Alternate
Environmental
Protection
Agency
Gerry
Brown,
Member
Paul
Campanella,
Alternate
National
Cancer
Institute
Alan
Poland,
Member
David
Longfellow,
Alternate
National
Institute
of
Environmental
Health
Sciences
Scott
Masten,
Member
William
Eastin,
Alternate
National
Institute
for
Occupational
Safety
and
Health
Mark
Toraason,
Member,
Chair
Dennis
W.
Lynch,
Alternate
National
Science
Foundation
Marge
Cavanaugh,
Member
Parag
R.
Chitnis,
Alternate
Occupational
Safety
and
Health
Administration
Val
H.
Schaeffer,
Member
Maureen
Ruskin,
Alternate
Liaison
Organizations
and
Their
Representatives
Agency
for
Toxic
Substances
and
Disease
Registry
William
Cibulas,
Member
Daphne
Moffett,
Alternate
Consumer
Product
Safety
Commission
Treye
Thomas,
Member
Jacqueline
Ferrante,
Alternate
Department
of
Agriculture
Clifford
P.
Rice,
Member
Laura
L.
McConnell,
Alternate
Department
of
Defense
Barbara
Larcom,
Member
Warren
Jederberg,
Alternate
Department
of
the
Interior
Barnett
A.
Rattner,
Member
Food
and
Drug
Administration
Kirk
Arvidson,
Alternate
Ronald
F.
Chanderbhan,
Alternate
National
Library
of
Medicine
Vera
W.
Hudson,
Member
National
Toxicology
Program
NIEHS,
FDA,
and
NIOSH
Members
Technical
Support
Contractor
Syracuse
Research
Corporation
ITC
Staff
John
D.
Walker,
Director
Norma
S.
L.
Williams,
Executive
Assistant
TSCA
Interagency
Testing
Committee,
Office
of
Pollution
Prevention
and
Toxics
(
7401),
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460
 
0001;
telephone
number:
(
202)
564
 
7527;
fax
number:
(
202)
564
 
7528;
e­
mail
address:
williams.
norma@
epa.
gov;
url:
http://
www.
epa.
gov/
opptintr/
itc.
[
FR
Doc.
04
 
894
Filed
1
 
14
 
04;
8:
45
am]

BILLING
CODE
6560
 
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