Document ID: EPA-HQ-OPP-2007-0309-0008
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2007-12-26T05:00Z

SEQ CHAPTER \h \r 1 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF           

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM

DATE:  	06-NOV-2007

SUBJECT:	Etoxazole.  REVISED:  Chronic Dietary Exposure and Risk
Assessment for the Section 3 Registration Action on Cherries, Hops, and
Melon, Subgroup 9A.  PC Code: 107091; Decision #: 373129;  DP#: 341211;
PP#: 6E7150.

		DP#: 346200.	Decision#: 373129.

		

FROM/TO:	Jennifer R. Tyler, Chemist

		Sarah J. Levy, Chemist

		Registration Action Branch (RAB1)

		Health Effects Division (HED) (7509P)

THROUGH:	George F. Kramer, Ph.D., Senior Chemist

RAB1/HED (7509P)

				and

		Thurston Morton, Chemist

		Ajay Parmar, Biologist

		Dietary Exposure Science Advisory Council (DESAC)/HED (7509P)

This memorandum supersedes the previous document (DP#: 341211).

Executive Summary

king water) exposure and risk assessments were conducted using the
Dietary Exposure Evaluation Model DEEM-FCID™, Version 2.03 which use
food consumption data from the U.S. Department of Agriculture’s
(USDA’s) Continuing Surveys of Food Intakes by Individuals (CSFII)
from 1994-1996 and 1998.  The analyses were performed to evaluate
establishment of tolerances for residues of etoxazole in/on cherries,
hops, and melon, subgroup 9A.  Based on the toxicological database for
etoxazole, only a chronic assessment was conducted.

The chronic dietary assessment was based on tolerance-level residues for
all agricultural commodities, assumed 100% crop treated (CT), used DEEM
7.81 default processing factors, and directly incorporated modeled
etoxazole estimated drinking water concentrations (EDWCs).

Risk estimates for the chronic assessment range from <1% of the chronic
PAD (cPAD) to 8% of the cPAD.  Generally, HED is concerned when dietary
risk estimates exceed 100% of the PAD.

Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population-adjusted dose
(PAD).  The PAD is equivalent to the point of departure (POD, NOAEL,
LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  References which
discuss the acute and chronic risk assessment in more detail are
available on the EPA/pesticides web site:  “Available Information on
Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web
link:   HYPERLINK
"http://www.epa.gov/fedrgstr/EPA_PEST/2000/July/Day_12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA_PEST/2000/July/Day_12/6061.pdf  ; or see
SOP 99.6 (8/20/99).

The most recent dietary risk assessment for etoxazole was conducted by
J. Tyler (Memo, 3/30/05; DP# 314198).

Residue Information

Registered and Proposed Tolerances:  Etoxazole is currently registered
in the U.S. for the control of mites on various raw agricultural
commodities (RACs).  Permanent tolerances have been established for
residues of etoxazole in/on plant and livestock commodities (40 CFR
§180.593).  The current petition is for the establishment of tolerances
for residues of etoxazole in/on cherries, hops and melon, subgroup 9A. 
The currently registered tolerances as well as the HED-recommended 
tolerances for cherries, hops and melon, subgroup 9A are listed in Table
1.

Nature of the Residue:  On 4/23/03, the HED Metabolism Assessment Review
Committee (MARC) met to determine the residues of concern in plant and
livestock commodities (Memo, J. Tyler et al., 4/24/03; D288817; TXR No.
0051966).  For apples, oranges, eggplant and cottonseed, MARC concluded
that the residues of concern for both tolerance expression and risk
assessment is parent only (Memo, J. Tyler 6/17/03; D289666).  For cotton
gin byproducts, the residue of concern for tolerance expression is
parent only.  For risk assessment the residues of concern in cotton gin
byproducts and almond hulls are parent and Metabolite R-3.  For ruminant
 muscle, fat and milk, the residue of concern for tolerance expression
and risk assessment is parent only.  For ruminant liver and kidney, the
residue of concern for tolerance expression is parent only, but parent
and Metabolite 1 should be included in the risk assessment.

The metabolites of concern for risk assessment purposes in cotton gin
byproducts (etoxazole and Metabolite R-3) and ruminant liver and kidney
(etoxazole and Metabolite 1) were included in previous dietary exposure
assessment (Memo, J. Tyler, 7/29/03; D291694).  In order to include the
residues of concern in almond hulls (parent and Metabolite R-3), the
metabolites of concern for risk assessment purposes were recalculated
for ruminant liver and kidney (see Attachment 3).  It should be noted
that the residue values (etoxazole and Metabolite 1) increased slightly
from 0.0017 ppm to 0.0025 ppm for ruminant liver, and from 0.0046 ppm to
0.0067 ppm for ruminant kidney.  As the calculated residue level
(etoxazole and Metabolite 1) for liver is less than the established
tolerance of 0.01 ppm, the tolerance-level residue was used in the
chronic dietary exposure assessment.  The residue values for risk
assessment purposes are listed in Table 1.

Drinking Water Considerations:  The Environmental Fate and Effects
Division (EFED) provided Estimated Drinking Water Concentrations (EDWCs)
of etoxazole and the metabolites of concern (R-8 and R-13) in surface
and ground water using the Food Quality Protection Act (FQPA) Index
Reservoir Screening Tool (FIRST) and Screening Concentration in Ground
Water (SCI-GROW) models, respectively.  The assessment was based on the
proposed hops use, which has a maximum proposed seasonal application
rate of 0.18 lb ai/A.  EFED calculated the 1-in-10-year estimated annual
mean non-cancer chronic EDWCs for etoxazole, R-8 and R-13 in surface
water to be 1.27 ppb.  The ground water EDWC for chronic exposures is
estimated as 0.318 ppb.

Percent Crop Treated:   For the chronic assessment, it was assumed that
100% of the registered and proposed crops have been treated with
etoxazole.

Residue and PDP Data:  HED-recommended tolerance level residues were
used for all registered and proposed commodities in the chronic
assessment.

Processing Factors:  As available submitted processing data indicate
that residues of etoxazole do not concentrate in apple juice, and
cottonseed hulls, meal and oil (Memo, J. Tyler, 7/31/03; D283737),
default processing factor was set to 1 for these commodities, where
applicable.  A citrus processing study was not submitted in support of
the tangerine tolerance; therefore, the default processing factor was
used for tangerine juice (2.3x).  An adequate grape processing study is
not available.  However, using the Office of Prevention, Pesticides, and
Toxic Substances (OPPTS) guideline theoretical concentration factors for
grape juice and raisins, and the highest-average field trial (HAFT)
value from the submitted crop field trials, HED determined that a
tolerance for grape juice is not needed, but a tolerance of 1.5 ppm for
raisin is needed (Memo in progress, J. Tyler; D303628).  The default
processing factor for grape, juice was set to 1.  See Table 1 for a
complete list of the processing factors used in this assessment.



Table 1.  HED-Recommended Tolerances and Residue Values for Risk
Assessment Purposes.

Commodity	Recommended Tolerance (ppm)1	Residue Values for Chronic
Dietary Exposure Assessment (ppm)2	Processing Factors

Proposed Uses

Cherry	1.0	1.0	Default value

Hop, dried cones	7.0	7.0	Not applicable (NA)

Vegetable, cucurbit subgroup 9A	020	0.20	NA

Registered Uses

Nut, tree, group 14	0.01	0.01	NA

Almond, hull	2.0	NA7	NA

Pistachio	0.01	0.01	NA

Grape	0.5	0.5	Grape, juice=1.0 (default value set to 1); Grape, leaves =
1.0 (default value); Grape, wine and sherry=1.0 (default value); Grape,
raisin=see below

Grape, raisin	1.5	1.5	Default value set to 1

Fruit, Pome, Group 11	0.20	0.20	Apple, juice=1.0 (default value set to
1); Apple, dried=8.0 (default value); Apple, sauce=1.0 (default value);
Pear, dried=6.25 (default value); Pear, juice =1.0 (default value)

Apple, pomace wet	0.50	NA3	NA

Strawberry	0.50	0.50	Strawberry, juice=1.0 (default value)

Cottonseed	0.05	0.05	Cottonseed, oil=1.0 (default value)

Cotton Gin Byproducts	1.0	NA4	NA

Tangerine	0.10	0.10	Tangerine, juice=2.3 (default value)

Liver 	0.01	0.015	NA

Kidney*, 6	NA	0.0067	NA

Fat*	0.02	0.02	NA

Milk, fat	0.01	0.01	NA

* of cattle, goat, horse, and sheep

1. The residue of concern for tolerance purposes for all plant and
livestock commodities is parent only.

2.  Residues to be included in risk assessment for pome fruit,
strawberry and cottonseed is parent only.  Residue to be included in
risk assessment for cotton by-products are parent and Metabolite R-3. 
Residues to be included in risk assessment for ruminant muscle, fat and
milk is parent only.  Residues to be included in risk assessment for
ruminant liver and kidney are parent and Metabolite 1.

3. As this wet apple pomace is a livestock feed item only, it was not
included in the chronic dietary exposure assessment.

4.  For chronic dietary exposure assessment, the average combined
residue (parent and Metabolite R-3) was determined to be 0.43 ppm, which
is less than the HED-recommended tolerance of 1.0 ppm.  Therefore,
HED-recommended tolerance level of 1.0 ppm was used to calculate the
appropriate livestock diet for risk assessment purposes.  As this cotton
gin byproducts is a livestock feed item only, it was not included in the
chronic dietary exposure assessment.

5.  The calculated residue level (etoxazole and Metabolite 1) of 0.0025
ppm is less than the HED-recommended tolerance of 0.01 ppm.  Therefore,
the tolerance-level residue will be use in the chronic dietary exposure
assessment.

6.  The results of the submitted livestock feeding study indicate that
tolerance for residues of etoxazole are not needed for livestock kidney
[180.6(a)(3)].  However, as quantifiable residues of Metabolite 1 (a
residue of concern for risk assessment purposes) were measured in kidney
in the feeding study, kidney (parent and Metabolite 1) was included in
the risk assessment.

DEEM-FCID™ Program and Consumption Information

The etoxazole chronic dietary exposure assessment was conducted using
DEEM-FCID™ (Version 2.03), which incorporates consumption data from
USDA’s CSFII, 1994-1996 and 1998.  The 1994-96, 98 data are based on
the reported consumption of more than 20,000 individuals over two
non-consecutive survey days.  Foods “as consumed” (e.g., apple pie)
are linked to EPA-defined food commodities (e.g. apples, peeled fruit -
cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S,
baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA.  Consumption data are averaged for the
entire U.S. population and within population subgroups for chronic
exposure assessment.

For chronic exposure and risk assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form.  The resulting residue
consumption estimate for each food/food form is summed with the residue
consumption estimates for all other food/food forms on the commodity
residue list to arrive at the total average estimated exposure. 
Exposure is expressed in mg/kg body weight/day and as a percent of the
cPAD.  This procedure is performed for each population subgroup.

Toxicological Information

Etoxazole was presented to the HED Hazard Identification Assessment
Review Committee (HIARC) on 2/2/03 (Memo, PV Shah, 3/19/03; TXR No.
0051659).  Based on the HIARC conclusions and the Etoxazole risk
assessment team’s evaluation of the hazard and exposure data, the team
recommended that the FQPA Safety Factor be reduced to 1x.  A summary of
the toxicological doses and endpoints selected for dietary exposure
assessment is provided in Table 2.

Table 2.  Summary of Toxicological Dose and Endpoints for Etoxazole for
Use in Human Health Risk Assessment1.

Exposure

Scenario	Dose Used in Risk Assessment (UF) 	FQPA SF* and Level of
Concern for Risk Assessment	Study and Toxicological Effects

Acute Dietary

(Females 13-50 years of age; as well as General population including
infants and children)	NOAEL = None mg/kg/day

UF = N/A

Acute RfD = None	FQPA SF = 1x

aPAD = acute RfD

              FQPA SF

= None	A dose and endpoint attributable to a single dose was not
available in the database including the developmental toxicity studies.

Chronic Dietary

(All populations)	NOAEL= 4.62 mg/kg/day

UF =100

Chronic RfD = 

0.046 mg/kg/day

	FQPA SF = 1x

cPAD = 

chronic RfD

 FQPA SF

= 0.046 mg/kg/day	Chronic Oral Toxicity Study- Dog

LOAEL = 23.5 mg/kg/day based upon increased alkaline phosphatase
activity, increased liver weights, liver enlargement (females), and
incidences of centrilobular hepatocellular swelling in the liver.

Cancer (oral, dermal, inhalation)	The HIARC classified etoxazole as
“not likely to be carcinogenic to humans” according to EPA Proposed
Guidelines for Carcinogen Risk Assessment (April 10, 1996).

1 UF = uncertainty factor, FQPA SF = FQPA safety factor, NOAEL =
no-observed-adverse-effect-level, LOAEL =
lowest-observed-adverse-effect-level, cPAD = chronic population adjusted
dose, RfD = reference dose.

Results/Discussion/Conclusions

Generally, HED’s level of concern is when the exposure is greater than
100% of the PAD.  That is, estimated exposures above this level are of
concern, while estimated exposures at or below this level are not of
concern.  The DEEM-FCID™ analysis estimates the dietary exposure of
the U.S. population and 26 population subgroups.  The results reported
in Table 3 are for the U.S. Population, all infants (<1 year old),
children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49,
males 20-49, and adults 50+ years.

The chronic dietary assessment was based on tolerance-level residues for
all agricultural commodities, assumed 100% CT, used DEEM 7.81 default
processing factors, and directly incorporated modeled etoxazole EDWC. 
This assessment concludes that the chronic dietary exposure estimates
are below HED’s level of concern (<100% cPAD) for the general U.S.
population (1.6% cPAD) and all population subgroups.  The most highly
exposed population subgroup is children 1-2 years old at 8.3% of the
cPAD.

Table 3.  Summary of Dietary Exposure and Risk for Etoxazole.

Population

Subgroup	Acute Dietary1	Chronic Dietary2

	Dietary Exposure

(mg/kg/day)	% aPAD	Dietary Exposure

(mg/kg/day)	% cPAD

U.S. Population (total)	Not applicable.	0.000735	1.6

All Infants (< 1 year old)

0.002089	4.5

Children 1-2 years old

0.003805	8.3

Children 3-5 years old

0.002464	5.4

Children 6-12 years old

0.000997	2.2

Youth 13-19 years old

0.000402	0.9

Adults 20-49 years old

0.00451	1.0

Adults 50+ years old

0.00484	1.1

Females 13-49 years old

0.00434	0.9

1 No acute dietary endpoint was chosen for the general U.S. population
or any population subgroup, including infants and children.

2 Chronic dietary endpoint of 0.046 mg/kg/day applies to the general
U.S. population and all population subgroups.

List of Attachments

Attachment 1.  Residue File for Chronic DEEM-FCID™ Analysis.

Attachment 2.  Chronic DEEM-FCID™ Analysis.

cc (w/Attachments): J. Tyler (RAB1), S. Levy (RAB1)

RDI: DE SAC [A. Parmar (11/06/07), T. Morton (11/06/07)]; G. Kramer
(11/06/07)

S. Levy:S10953:(703)305-0783: 7509P:RAB1

Attachment 1.  Residue File for Chronic DEEM-FCID™ Analysis.

U.S. Environmental Protection Agency                                Ver.
2.00

DEEM-FCID Chronic analysis for ETOXAZOLE                         1994-98
data

Residue file: C:\Documents and Settings\slevy\Desktop\107091.r98

                                                              Adjust. #2
used

Analysis Date 11-05-2007            Residue file dated:
11-05-2007/09:38:17/8

Reference dose (RfD) = 0.046 mg/kg bw/day

Comment:Section 3 for use on cherries, hops and melon, subgroup 9A.

------------------------------------------------------------------------
-----

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   

14000030 14   Almond                             0.010000   1.000     
1.000   

  Full comment: Parent only

14000031 14   Almond-babyfood                    0.010000   1.000     
1.000   

  Full comment: Parent only

14000040 14   Almond, oil                        0.010000   1.000     
1.000   

  Full comment: Parent only

14000041 14   Almond, oil-babyfood               0.010000   1.000     
1.000   

  Full comment: Parent only

11000070 11   Apple, fruit with peel             0.200000   1.000     
1.000   

  Full comment: Parent only

11000080 11   Apple, peeled fruit                0.200000   1.000     
1.000   

  Full comment: Parent only

11000081 11   Apple, peeled fruit-babyfood       0.200000   1.000     
1.000   

  Full comment: Parent only

11000090 11   Apple, dried                       0.200000   8.000     
1.000   

  Full comment: Parent only; Default processing factor.

11000091 11   Apple, dried-babyfood              0.200000   8.000     
1.000   

  Full comment: Parent only; Default processing factor.

11000100 11   Apple, juice                       0.200000   1.000     
1.000   

  Full comment: Parent only; Default processing factor set to 1.

11000101 11   Apple, juice-babyfood              0.200000   1.000     
1.000   

  Full comment: Parent only; Default processing factor set to 1.

11000110 11   Apple, sauce                       0.200000   1.000     
1.000   

  Full comment: Parent only

11000111 11   Apple, sauce-babyfood              0.200000   1.000     
1.000   

  Full comment: Parent only

21000470 M    Beef, fat                          0.020000   1.000     
1.000   

  Full comment: Parent only

21000471 M    Beef,fat-babyfood                  0.020000   1.000     
1.000   

  Full comment: Parent only

21000480 M    Beef, kidney                       0.006700   1.000     
1.000   

  Full comment: Parent and Metabolite 1

21000490 M    Beef, liver                        0.010000   1.000     
1.000   

  Full comment: Parent and Metabolite 1

21000491 M    Beef, liver-babyfood               0.010000   1.000     
1.000   

  Full comment: Parent and Metabolite 1

14000590 14   Brazil nut                         0.010000   1.000     
1.000   

  Full comment: Parent only

14000680 14   Butternut                          0.010000   1.000     
1.000   

  Full comment: Parent only

09010750 9A   Cantaloupe                         0.200000   1.000     
1.000     Full comment: New, parent only

09010800 9A   Casaba                             0.200000   1.000     
1.000     Full comment: New, parent only

14000810 14   Cashew                             0.010000   1.000     
1.000     Full comment: New, parent only

12000900 12   Cherry                             1.000000   1.000     
1.000     Full comment: New, parent only

12000901 12   Cherry-babyfood                    1.000000   1.000     
1.000     Full comment: New, parent only

12000910 12   Cherry, juice                      1.000000   1.500     
1.000     Full comment: New, parent only

12000911 12   Cherry, juice-babyfood             1.000000   1.500     
1.000     Full comment: New, parent only

14000920 14   Chestnut                           0.010000   1.000     
1.000     Full comment: Parent only

95001280 O    Cottonseed, oil                    0.050000   1.000     
1.000     Full comment: Parent only; Default processing factor.

95001281 O    Cottonseed, oil-babyfood           0.050000   1.000     
1.000     Full comment: Parent only; Default processing factor.

11001290 11   Crabapple                          0.200000   1.000     
1.000     Full comment: Parent only

14001550 14   Filbert                            0.010000   1.000     
1.000     Full comment: Parent only

14001560 14   Filbert, oil                       0.010000   1.000     
1.000     Full comment: Parent only

23001710 M    Goat, fat                          0.020000   1.000     
1.000   

  Full comment: Parent only

23001720 M    Goat, kidney                       0.006700   1.000     
1.000   

  Full comment: Parent and Metabolite 1

23001730 M    Goat, liver                        0.010000   1.000     
1.000   

  Full comment: Parent and Metabolite 1

95001750 O    Grape                              0.500000   1.000     
1.000   

  Full comment: Parent only

95001760 O    Grape, juice                       0.500000   1.000     
1.000   

  Full comment: Processing factor set to one; parent only

95001761 O    Grape, juice-babyfood              0.500000   1.000     
1.000   

  Full comment: Processing factor set to one; parent only

95001770 O    Grape, leaves                      0.500000   1.000     
1.000   

  Full comment: Parent only

95001780 O    Grape, raisin                      1.500000   1.000     
1.000   

  Full comment: Processing factor set to one; parent only

95001790 O    Grape, wine and sherry             0.500000   1.000     
1.000   

  Full comment: Parent only

14001850 14   Hickory nut                        0.010000   1.000     
1.000   

  Full comment: Parent only

09011870 9A   Honeydew melon                     0.200000   1.000     
1.000         Full comment: New, parent only

95001880 O    Hop                                7.000000   1.000     
1.000     Full comment: New, parent only

11002100 11   Loquat                             0.200000   1.000     
1.000     Full comment: Parent only

14002130 14   Macadamia nut                      0.010000   1.000     
1.000     Full comment: Parent only

27002220 D    Milk, fat                          0.010000   1.000     
1.000   

  Full comment: Parent only

27002221 D    Milk, fat - baby food/infant for   0.010000   1.000     
1.000     Full comment: Parent only

11002660 11   Pear                               0.200000   1.000     
1.000   

  Full comment: Parent only

11002661 11   Pear-babyfood                      0.200000   1.000     
1.000   

  Full comment: Parent only

11002670 11   Pear, dried                        0.200000   6.250     
1.000   

  Full comment: Parent only; Default processing factor.

11002680 11   Pear, juice                        0.200000   1.000     
1.000   

  Full comment: Parent only; Default processing factor.

11002681 11   Pear, juice-babyfood               0.200000   1.000     
1.000   

  Full comment: Parent only; Default processing factor.

14002690 14   Pecan                              0.010000   1.000     
1.000   

  Full comment: Parent only

14002820 14   Pistachio                          0.010000   1.000     
1.000   

  Full comment: Parent only

11003100 11   Quince                             0.200000   1.000     
1.000   

  Full comment: Parent only

26003410 M    Sheep, fat                         0.020000   1.000     
1.000   

  Full comment: Parent only

26003411 M    Sheep, fat-babyfood                0.020000   1.000     
1.000   

  Full comment: Parent only

26003420 M    Sheep, kidney                      0.006700   1.000     
1.000   

  Full comment: Parent and Metabolite 1

26003430 M    Sheep, liver                       0.010000   1.000     
1.000   

  Full comment: Parent and Metabolite 1

95003590 O    Strawberry                         0.500000   1.000     
1.000   

  Full comment: Parent only

95003591 O    Strawberry-babyfood                0.500000   1.000     
1.000   

  Full comment: Parent only

95003600 O    Strawberry, juice                  0.500000   1.000     
1.000   

  Full comment: Parent only; Default processing factor.

95003601 O    Strawberry, juice-babyfood         0.500000   1.000     
1.000   

  Full comment: Parent only; Default processing factor.

10003690 10   Tangerine                          0.100000   1.000     
1.000   

  Full comment: Parent only

10003700 10   Tangerine, juice                   0.100000   2.300     
1.000   

  Full comment: Parent only; Default processing factor.

14003910 14   Walnut                             0.010000   1.000     
1.000   

  Full comment: Parent only

86010000 O    Water, direct, all sources         0.001270   1.000     
1.000     Full comment: EDWC = 1.27 ppb

86020000 O    Water, indirect, all sources       0.001270   1.000     
1.000     Full comment: EDWC = 1.27 ppb

09013990 9A   Watermelon                         0.200000   1.000     
1.000     Full comment: New, parent only

09014000 9A   Watermelon, juice                  0.200000   1.000     
1.000     Full comment: New, parent only

D™ Analysis.

U.S. Environmental Protection Agency                                Ver.
2.00

DEEM-FCID Chronic analysis for ETOXAZOLE                       (1994-98
data)

Residue file name: C:\Documents and Settings\slevy\Desktop\107091.r98

                                                   Adjustment factor #2
used.

Analysis Date 11-05-2007/09:48:47   Residue file dated:
11-05-2007/09:38:17/8

Reference dose (RfD, Chronic) = .046 mg/kg bw/day

COMMENT 1: Section 3 for use on cherries, hops and melon, subgroup 9A.

========================================================================
=====

                    Total exposure by population subgroup

------------------------------------------------------------------------
-----

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.000735                
1.6%

U.S. Population (spring season)             0.000762                
1.7%

U.S. Population (summer season)             0.000802                
1.7%

U.S. Population (autumn season)             0.000688                
1.5%

U.S. Population (winter season)             0.000688                
1.5%

Northeast region                            0.000824                
1.8%

Midwest region                              0.000747                
1.6%

Southern region                             0.000623                
1.4%

Western region                              0.000820                
1.8%

Hispanics                                   0.000708                
1.5%

Non-hispanic whites                         0.000754                
1.6%

Non-hispanic blacks                         0.000642                
1.4%

Non-hisp/non-white/non-black                0.000755                
1.6%

All infants (< 1 year)                      0.002089                
4.5%

Nursing infants                             0.001082                
2.4%

Non-nursing infants                         0.002471                
5.4%

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Children 1-6  yrs                           0.002746                
6.0%

Children 7-12 yrs                           0.000911                
2.0%

Females 13-19 (not preg or nursing)         0.000415                
0.9%

Females 20+ (not preg or nursing)           0.000452                
1.0%

Females 13-50 yrs                           0.000482                
1.0%

Females 13+ (preg/not nursing)              0.000480                
1.0%

Females 13+ (nursing)                       0.000678                
1.5%

Males 13-19 yrs                             0.000388                
0.8%

Males 20+ yrs                               0.000471                
1.0%

Seniors 55+                                 0.000494                
1.1%

Children 1-2 yrs                            0.003805                
8.3%

Children 3-5 yrs                            0.002464                
5.4%

Children 6-12 yrs                           0.000997                
2.2%

Youth 13-19 yrs                             0.000402                
0.9%

Adults 20-49 yrs                            0.000451                
1.0%

Adults 50+ yrs                              0.000484                
1.1%

Females 13-49 yrs                           0.000434                
0.9%

Etoxazole	                               Dietary Exposure and Risk
Assessment	                             DP#: 346200

PC Code:  107091

________________________________________________________________________
_____________________

 PAGE   14 

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