Document ID: EPA-HQ-OPP-2005-0249-0002
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2005-12-06T05:00Z

November
18,
2005
FIFRA
SCIENTIFIC
ADVISORY
PANEL
(
SAP)
OPEN
MEETING
DECEMBER
6­
8,
2005
FIFRA
SAP
WEB
SITE
http://
www.
epa.
gov/
scipoly/
sap/
OPP
Docket
Telephone:
(
703)
305­
5805
Docket
Number:
OPP­
2005­
0249
PLANT­
INCORPORATED
PROTECTANTS
BASED
ON
VIRUS
COAT
PROTEIN
GENES:
SCIENCE
ISSUES
ASSOCIATED
WITH
THE
PROPOSED
RULE
Judith
Bender,
Ph.
D.

Dr.
Judith
Bender
is
an
Associate
Professor
in
the
Department
of
Biochemistry
and
Molecular
Biology,
Johns
Hopkins
Bloomberg
School
of
Public
Health.
Her
research
interests
focus
on
DNA
methylation
and
gene
silencing
in
Arabidopsis
and
the
regulation
of
tryptophan
metabolism
in
Arabidopsis.
Dr.
Bender
has
a
B.
S.
in
Biochemistry
from
Harvard­
Radcliffe
College,
a
Ph.
D.
in
Biochemistry
from
Harvard
University
and
completed
a
Postdoctoral
Fellowship
in
Biology
from
Whitehead
Institute
for
Biomedical
Research.

Judith
Brown,
Ph.
D.

Dr.
Brown
is
a
Professor
in
the
Department
of
Plant
Sciences
at
the
University
of
Arizona.
Dr.
Brown's
research
interests
are
(
1)
begomovirus/
satellite
DNA
diversity
and
diversification
mechanisms,
pathogenesis
(
2)
biotype
formation­
Bemisia
tabaci
(
Genn.)
complex,
role
of
endosymbionts
in
B.
tabaci
speciation
(
3)
whitefly
genome
(
ESTs)/
proteomics
to
elucidate
transmission
pathway
(
4)
begomovirus
resistance/
transgenic
plants­
gene
silencing.
Dr.
Brown
has
a
Ph.
D.
in
Plant
Pathology
from
the
University
of
Arizona,
a
MS
in
Plant
Pathology
from
Washington
State
University
and
BS
in
Horticultural
Science
from
Texas
A&
M
University.

George
Cobb,
Ph.
D.

Dr.
Cobb
is
an
Associate
Professor
of
Environmental
Toxicology,
The
Institute
of
Environmental
and
Human
Health,
Texas
Tech
University
&
Texas
Tech
Health
Sciences
Center.
His
research
entails
improving
approaches
for
quantifying
exposure
and
trophic
transport
of
toxicants.
He
provides
coordinated
research
and
education
opportunities
for
students
in
toxicology,
environmental
chemistry,
environmental
chemistry,
sensor
development,
trace
analysis,
and
risk
assessment.
Dr.
Cobb
has
a
Ph.
D.
in
Chemistry
from
the
University
of
South
Florida
and
a
B.
S.
in
Chemistry
from
the
College
of
Charleston.
Shou­
Wei
Ding,
Ph.
D.

Dr.
Ding
is
a
Professor
in
the
Department
of
Plant
Pathology
and
the
Institute
for
Integrative
Genome
Biology
in
the
College
of
Natural
and
Agricultural
Sciences,
University
of
California,
Riverside.
He
received
his
PhD
from
the
Australian
National
University's
Research
School
of
Biological
Sciences
in
1990,
and
subsequently
completed
postdoctoral
training
in
plant
molecular
virology
at
the
Waite
Institute,
University
of
Adelaide,
South
Australia.
He
has
previously
served
on
the
faculty
of
the
Institute
of
Molecular
Agrobiology
at
the
National
University
of
Singapore.
Dr.
Ding
has
active
research
programs
funded
by
the
NIH,
USDA,
and
California
Citrus
Research
Board
to
investigate
mechanisms
of
virus­
host
interactions,
primarily
focusing
on
the
biology
and
application
of
gene
silencing
as
an
antiviral
immunity
in
both
plant
and
animal
systems.
His
teaching
responsibilities
at
the
University
of
California,
Riverside
include
undergraduate
and
graduate
courses
in
virology.
Dr.
Ding
is
an
editor
of
FEBS
Letters
(
Federation
of
European
Biochemistry
Societies).
He
also
serves
on
the
editorial
boards
of
Virology
and
Phytopathology.

Bryce
W.
Falk,
Ph.
D.

Dr.
Bryce
Falk
is
Professor,
Dept.
of
Plant
Pathology,
University
of
California,
Davis,
CA.
Dr.
Falk
received
his
BS
degree
in
Biology
from
Cal
Poly
in
San
Luis
Obispo,
California,
followed
by
MS
and
PhD
degrees
in
Plant
Pathology
from
the
University
of
California,
Berkeley.
After
postdoctoral
work
at
UC
Riverside
he
was
an
Assistant
Professor
at
the
University
of
Florida,
Everglades
Research
and
Education
Center
in
Belle
Glade.
In
1985
he
moved
to
UC
Davis
advancing
to
Full
Professor
in
1991.
He
has
served
on
a
number
of
Federal
Grant
review
panels
and
was
the
first
panel
manager
for
the
NRICGP
Biology
of
Plant
Microbe
Associations
program
in
2000.
He
has
served
on
editorial
boards
for
a
number
of
scientific
journals,
currently
for
Virology
and
Molecular
Plant
Pathology.
His
lab
research
has
been
focused
on
various
aspects
of
the
biology
and
molecular
biology
of
plant
viruses.
His
current
efforts
are
mainly
with
viruses
in
the
family
Closteroviridae,
genera
Crinivirus
and
Closterovirus.
He
is
examining
the
replication
and
host
plant
interactions/
determinants
for
Lettuce
infectious
yellows
virus
(
LIYV).
His
lab
is
using
immunological,
microscopic
and
molecular
biological
tools
to
assess
protein
accumulation
in
cells/
whole
plants
and
taking
a
mutagenic
approach
to
modify
specific
LIYV­
encoded
proteins
and
then
analyze
effects
on
function.
They
are
also
attempting
to
understand
LIYV­
encoded
determinants
that
effect
LIYV
transmission
by
the
whitefly,
Bemisia
tabaci.
His
lab
is
also
taking
novel
approaches
to
confer
resistance
to
Citrus
tristeza
virus
in
citrus
by
engineering
plants
to
respond
with
a
systemic
resistance
signal,
and
they
are
trying
to
better
understand
the
molecular
and
biological
factors
affecting
CTV
host:
plant
interactions
and
virus
evolution.
He
has
recently
also
evaluated
how
transgenic,
virus­
resistant
plants
may
affect
virus
populations
and
evolution
by
performing
field,
laboratory
and
greenhouse
studies
to
assess
the
genetic
composition
of
plant
virus
populations
and
how
selection
conferred
by
transgenic
resistance
may
direct
shifts
in
virus
genotype
populations.
In
2003
and
2004
he
was
named
Fellow
of
the
American
Association
for
the
Advancement
of
Science
(
AAAS)
and
the
American
Phytopathological
Society
(
APS),
respectively.

Steven
Gendel,
Ph.
D.

Dr.
Gendel
received
his
B.
S.
in
Chemical
Engineering
from
Case
Western
Reserve
University
and
his
Ph.
D.
in
Cell
Biology
from
the
University
of
California,
Irvine.
He
held
postdoctoral
positions
at
Harvard
University
and
the
University
of
Toronto
before
joining
the
Department
of
Genetics
at
Iowa
State
University.
Since
1990
he
has
been
with
the
FDA
at
the
National
Center
for
Food
Safety
and
Technology
in
Chicago
as
Chief
of
the
Biotechnology
Studies
Branch
and
now
as
Biotechnology
Program
Lead.
His
research
interests
focus
on
the
application
of
bioinformatics
to
food
safety,
particularly
as
related
to
food
biotechnology
and
food
allergens.

Jonathan
Gressel,
Ph.
D.

Dr.
Jonathan
Gressel
is
Professor
Emeritus
in
the
Department
of
Plant
Sciences,
Weizmann
Institute
of
Science,
Israel.
His
areas
of
expertise
are
plant
and
fungal
physiology,
biochemistry,
molecular
biology,
evolutionary
dynamics
in
agro­
ecosystems.
His
research
interests
focus
on
transgenic
herbicide
resistant
crops,
introgression
and
molecular
prevention
of
crop
transgenes
to
weeds,
herbicide
resistance,
herbicide
action,
parasitic
weeds
and
biotechnological
axenic
systems.
Dr.
Gressel
has
a
BS
in
Plant
Science
from
Ohio
State
University,
a
MS
in
Botany
from
the
University
of
Wisconsin
and
Ph.
D.
in
Botany/
horticulture
from
the
University
of
Wisconsin.

Simon
P.
Hogan,
Ph.
D.

Dr.
Simon
Hogan
is
Assistant
Professor
of
Pediatrics,
Division
of
Allergy
and
Immunology,
Cincinnati
Children's
Hospital
Medical
Center
,
Cincinnati
,
OH
.
He
received
his
Ph.
D.
from
the
John
Curtin
School
of
Medical
Research,
Australian
National
University
,
Canberra,
Australia
in
1998
and
subsequently
completed
a
National
Health
Medical
Research
Council
NHMRC
CJ
Martin
Fellowship
in
Allergy
and
Immunology
at
Cincinnati
Children's
Hospital
Medical
Center
,
Cincinnati
,
OH
.
He
was
appointed
in
2004
to
Head
of
the
Gastrointestinal
Research
laboratory,
John
Curtin
School
of
Medical
Research,
ANU,
Canberra
,
Australia
as
part
of
the
NHMRC
funded
Program
grant
to
examine
Molecular
mechanisms
in
the
regulation
of
allergy
and
inflammation.
Dr
Hogan
has
an
active
research
program
investigating
inflammation
induced
gastrointestinal
dysfunction.
Current
projects
are
(
1)
to
elucidate
the
cellular
and
molecular
processes
involved
in
gastrointestinal
allergic
responses
using
novel
models
of
allergic
responses
in
mice
with
translational
studies
in
humans,
(
2)
to
identify
the
role
of
gastrointestinal
inflammation
in
peristaltic
reflex
and
gastrointestinal
epithelial
cell
dysfunction
and
(
3)
to
characterize
food
allergen
reactive
T
cells
in
eosinophilic
esophagitis.

Roger
Hull,
DSc.
Dr.
Roger
Hull
is
an
Emeritus
Fellow
at
the
John
Innes
Centre
in
Norwich,
United
Kingdom.
He
has
a
BS
in
Botany
at
Cambridge
University,
a
PhD
in
Plant
Pathology
at
the
University
of
London
in
1964
and
a
DSc
in
Plant
Virology
by
the
University
of
London
in
1980.
Other
awards
include
Honorary
Professorships
at
the
University
of
East
Anglia,
Norwich,
UK
and
at
Peking
University,
China,
an
Honorary
Doctorate
at
the
University
of
Perpignan,
France
and
Fellowship
of
the
American
Phytopathological
Society.
His
research
interests
are
in
the
area
of
badnaviruses
and
tenuiviruses,
RNA
viruses
and
designing
resistance
in
plants
to
virus
infection
or
controlling
the
spread
of
viruses
from
plant
to
plant.
He
is
also
involved
in
biosafety
issues
relating
to
the
uptake
of
transgenic
crops
in
developing
countries.

Alexander
Karasev,
Ph.
D.

Dr.
Alexander
Karasev
is
an
Assistant
Professor,
Department
of
Microbiology
and
Immunology,
Thomas
Jefferson
University,
Philadelphia,
Pennsylvania.
His
research
focused
on
the
design
and
construction
of
novel
viral­
based
vectors
for
expression
of
foreign
gene
sequences
in
plants
and
development
of
plant­
based
oral
vaccines
for
viral
and
bacterial
infectious
diseases.
Dr.
Karasev
has
a
Ph.
D.
in
Molecular
Biology
from
Moscow
State
University,
Russia.

Steven
A.
Lommel,
Ph.
D.

Dr.
Steve
Lommel
is
the
Assistant
Vice­
Chancellor
for
Research
at
North
Carolina
State
University
and
is
a
Professor
with
joint
appointments
in
the
Departments
of
Plant
Pathology
and
Genetics
in
the
College
of
Agriculture
and
Life
Sciences.
He
received
his
Ph.
D.
from
the
University
of
California,
Berkeley
in
1983.
He
has
previously
served
on
the
faculty
at
Kansas
State
University
and
was
Assistant
Director
of
the
North
Carolina
Agriculture
Research
Service.
Dr.
Lommel
has
an
active
research
program
funded
by
the
NSF
to
explore
the
genetic
and
molecular
mechanisms
of
plant
virus
pathogenicity.
His
laboratory
is
interested
in
the
structure
of
robust
small
plant
viruses
with
the
goal
of
using
them
as
viral
based
nanotechnology
cargo
vehicles.
Dr.
Lommel
is
the
co­
Director
of
the
Nicotiana
Genome
Initiative
based
at
North
Carolina
State
University.
His
teaching
responsibilities
at
North
Carolina
State
University
include
graduate
courses
in
Plant
Pathology
and
Plant
Virology
as
well
as
invited
lectures
in
Biotechnology
and
Genetics.
Dr.
Lommel
is
the
editor
for
the
Journal
Virus
Research
and
sits
on
the
editorial
boards
of
several
other
plant
biology
and
virology
journals.
He
was
also
one
of
the
original
organizers
and
current
University
representative
for
PIPRA,
the
Public
Intellectual
Property
Resource
for
Agriculture.

Diana
Pilson,
Ph.
D.
Dr.
Diana
Pilson
is
an
Associate
Professor
of
Biological
Sciences
at
the
University
of
Nebraska,
where
she
has
been
on
the
faculty
since
1994.
She
received
her
Ph.
D.
from
Duke
University
(
Department
of
Zoology
and
the
University
Program
in
Genetics)
in
1990,
and
then
was
a
member
of
the
research
faculty
at
the
University
of
Montana.
Dr.
Pilson
has
an
active
research
program
examining
the
ecological
consequences
of
the
escape
of
transgenes
into
wild
populations
(
funded
by
the
USDA),
including
projects
evaluating
the
effects
of
insect
herbivores
on
the
population
dynamics
of
wild
sunflower
and
the
effects
of
virus
infection
on
wild
squash
populations.
Other
work
(
funded
by
USDA
and
NSF)
has
examined
the
evolution
of
plant
response
to
herbivore
attack
and
the
evolution
of
plant
mating
systems.
Her
teaching
responsibilities
include
undergraduate
and
graduate
courses
in
evolution
and
ecology.
She
has
served
on
proposal
review
panels
for
the
National
Science
Foundation
and
the
US
Department
of
Agriculture
Competitive
Grants
Program,
and
is
currently
a
member
of
the
Editorial
Board
for
Ecology/
Ecological
Monographs.

Alison
Power,
Ph.
D.

Dr.
Alison
G.
Power
is
a
Professor
in
the
Department
of
Ecology
and
Evolutionary
Biology
and
Dean
of
the
Graduate
School
at
Cornell
University
in
Ithaca,
New
York,
USA.
She
received
a
B.
S.
in
Biology
from
the
University
of
Alaska­
Fairbanks
and
a
Ph.
D.
in
Zoology
from
the
University
of
Washington
in
1985.
Her
research
focuses
on
the
ecology
of
viruses
in
plant
communities,
including
both
natural
and
agricultural
communities.
Current
research
also
addresses
the
impact
of
agriculture
on
the
spread
of
plant
diseases
in
natural
ecosystems
and
the
ecological
risks
of
genetically
engineered
crops
expressing
transgenic
virus
resistance.
Other
research
interests
include
biodiversity
conservation
in
managed
ecosystems,
interactions
between
agricultural
and
natural
ecosystems,
agroecology,
and
tropical
ecology.
Currently,
Power
serves
as
Vice­
President
for
Public
Affairs
for
the
Ecological
Society
of
America,
on
the
Executive
Committee
of
the
Association
of
Graduate
Schools,
and
on
the
Oversight
Committee
of
the
Collaborative
Crop
Research
Program
of
the
McKnight
Foundation.
She
has
served
on
the
Scientific
Advisory
Board
of
the
National
Center
for
Ecological
Analysis
and
Synthesis
(
NCEAS);
several
committees
of
the
National
Research
Council;
and
the
Executive
Committee
of
the
Organization
for
Tropical
Studies.

Lars
Poulsen,
Ph.
D.

Dr.
Lars
Poulsen
is
head
of
research
at
the
Allergy
Clinic
at
the
National
University
Hospital
in
Copenhagen,
Denmark.
In
addition,
he
serves
as
an
adjunct
Professor
of
Immunology
at
the
Danish
Technical
University
and
as
external
associate
professor
in
Basic
Allergology
at
the
Faculty
of
Medicine
at
the
University
of
Copenhagen.
Dr.
Poulsen
serves
as
a
manager
of
a
national
allergy
research
programme
at
the
Danish
Allergy
Research
Center.
Dr.
Poulsen
has
a
Ph.
D.
from
the
Univeristy
of
Copenhagen
Medical
Faculty,
Danish
Doctorate
of
Medical
Sciences
at
the
University
of
Copenhagen
and
postdoctoral
training
at
the
Department
of
Immunology
at
Johns
Hopkins
University.
Geoffrey
I.
Scott,
Ph.
D.

Dr.
Geoff
Scott
is
the
Director
of
the
Center
for
Coastal
Environmental
Health
and
Biomolecular
Research
at
Charleston,
SC,
National
Centers
of
Coastal
Ocean
Science,
National
Ocean
Service,
NOAA.
Dr.
Scott
holds
adjunct
faculty
appointments
at
the
Medical
University
of
South
Carolina,
University
of
South
Carolina,
University
of
Charleston,
and
Texas
Technical
University.
He
received
his
Ph.
D.
in
marine
science
from
the
University
of
South
Carolina
in
1979.
Research
experience
includes
working
as
an
aquatic
toxicologist
for
the
EPA
and
the
Research
Planning
Institute,
as
well
as,
an
Associate
Professor
in
the
School
of
Public
Health
at
the
University
of
South
Carolina
where
his
research
was
focused
on
understanding
the
impacts
of
agricultural
pesticide
NPS
runoff
and
mosquito
control
agents
on
estuarine
ecosystems,
and
the
health
of
estuarine
organisms
as
well
as
methods
for
measuring
bacterial
pollution
emanating
from
different
septic
tanks
systems
in
the
coastal
zone
of
SC.
Additional
research
has
focused
on
the
impacts
of
oil
and
hazardous
material
spills
on
coastal
ecosystems
throughout
the
U.
S.
including
studies
in
Alaska,
Puget
Sound,
Texas,
Puerto
Rico
and
the
Florida
Keys.
His
research
at
NOAA
has
focused
on
agricultural
and
urban
nonpoint
source
runoff
issues
throughout
the
southeastern
US.
His
teaching
responsibilities
at
the
University
of
South
Carolina
include
courses
in
environmental
health
sciences
and
aquatic
toxicology.
Dr.
Scott
has
served
on
numerous
advisory
panels
to
government
and
industry
including:
(
1)
the
Interstate
Shellfish
Sanitation
Conference;
(
2)
EPA's
Advisory
Board,
Panel
on
Endocrine
Disrupting
Chemicals;
(
3)
EPA's
Food
Quality
Protection
Act
Board,
Scientific
Panel
Member;
(
4)
EPA's
Environmental
Technology
Verification
Program,
Water
Stakeholder
Committee
Member;
(
5)
Governor's
Primary
Health
Care
Task
Force;
(
6)
the
SC
Coastal
Pesticide
Advisory
Committee;
(
7)
SC
Sea
Grant
Advisory
Board;
(
8)
Editorial
Board
Aquatic
Toxicology;
and
(
9)
United
Nations
Gulf
of
Guinea
Large
Marine
Ecosystem
Study
Technical
Advisor.