Document ID: EPA-HQ-OPP-2007-0339-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2008-05-28T04:00Z

`  SEQ CHAPTER \h \r 1 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF              

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM

DATE:  	19-MAR-2008 

SUBJECT:	2,6-Dichlorobenzamide (BAM) as a Metabolite of Fluopicolide and
Dichlobenil.  Acute and Chronic Aggregate Dietary (Food and Drinking
Water) Exposure and Risk Assessments for the Section 3 Registration
Actions for Fluopicolide on Root Vegetables (Subgroup 1A), Leaves of
Root and Tuber Vegetables (Group 2), Bulb Vegetables (Group 3), and Head
and Stem Brassica (Subgroup 5A)

					and 

		Section 3 Registration Actions for Dichlobenil on Rhubarb, Caneberries
(Subgroup 13-07A), Bushberries (Subgroup 13-07B) and Associated Berry
Commodities. 

PC Codes: 027402(BAM), 027401(Dichlobenil) and 027412(Fluopicolide)

Decision Number: 	373401

DP Number: 		349722	

REVIEWERS:	Debra Rate, Ph.D., Biologist

				Sheila Piper, Chemist

Alternative Risk Integration and Assessment (ARIA) Team 

Risk Integration, Minor Use and Emergency Response (RIMUER) Branch 

Registration Division-RD (7505P)

THROUGH:	Thurston Morton, Chemist

Mohsen Sahafeyan, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division-HED (7509P)

and

			William Cutchin, Acting Senior Branch Scientist

			ARIA/RIMUERB/RD (7505P)

TO:		Felecia Fort, Risk Assessor

Reregistration Branch 1/ HED (7509P)

and

Janet Whitehurst/Tony Kish, RM Team #22

		Fungicide Branch/RD (7505P)

Executive Summary

Acute and chronic dietary (food and drinking water) exposure and risk
assessments were conducted using the Dietary Exposure Evaluation Model
DEEM-FCID™, Version 2.03, which use food consumption data from the
U.S. Department of Agriculture’s Continuing Surveys of Food Intakes by
Individuals (CSFII) from 1994-1996 and 1998.  The analyses were
performed on BAM to support Section 3 requests for use of parent
fluopicolide on root vegetables, leaves of root and tuber vegetables,
bulb vegetables, and head and stem Brassica and the Section 3 requests
for use of parent dichlobenil on rhubarb, caneberries, bushberries and
associated berry commodities.

BAM will be included in risk assessments for domestic crops.  This
assessment is for residues of BAM from uses of fluopicolide and
dichlobenil.  A separate assessment (D349721, S.Piper, 19-MAR-08) has
been conducted for fluopicolide (parent) and a separate assessment
(D341453, D.Rate, in process) is being conducted concurrently for
dichlobenil (parent).  BAM is a metabolite and/or environmental
degradate of both fluopicolide and dichlobenil. 

Acute and Chronic Dietary (Food and Drinking Water) Exposure Results and
Characterization

Conservative acute and chronic (food and drinking water) exposure
assessments were conducted.  Maximum residues of BAM from fluopicolide
field trials on root vegetables, leaves of root and tuber vegetables,
bulb vegetables, and head and stem Brassica, and from dichlobenil field
trials on food commodities with established/pending tolerances (40 CFR
180.231) were included in the assessments.  The assessments used 100%
crop treated except for apples, blueberries, cherries, cranberries,
peaches, pears, and raspberries.  No livestock tolerances are
established or proposed for either fluopicolide or dichlobenil.  DEEM
(version 7.81) default processing factors were used.

The drinking water residue level used in this dietary risk assessment is
the estimate of residues of BAM from use of dichlobenil.  This
assessment will use 56.2 ppb (from Screening Concentration in Ground
Water-SCIGROW modeling of BAM residues from dichlobenil use on nutsedge)
for the drinking water estimate for both the acute and chronic
exposures.

The results of the acute dietary analysis for food and drinking water
indicate that acute dietary risks do not exceed the Agency’s level of
concern (<100% of the aPAD) for the U.S. population and all subgroups. 
Combined dietary exposure from food and drinking water at the 99.9th
percentile of exposure is estimated to be 0.011650 mg/kg/day for the
overall U.S. population, equivalent to 12% of the acute Population
Adjusted Dose (aPAD).  The population subgroup with the highest
estimated acute dietary exposure is all infants (<1 year old) of
0.028470 mg/kg/day, equivalent to 28% of the aPAD.

Chronic dietary exposure estimates for food and drinking water are well
below HED’s level of concern (<100% cPAD) for all population
subgroups.  The dietary exposure is estimated at 0.001317 mg/kg/day for
the general U.S. population (29% of the chronic Population Adjusted Dose
(cPAD)) and 0.004170 mg/kg/day (93% of the cPAD) for infants (<1 year
old), the population subgroup with the highest estimated chronic dietary
exposure to BAM from fluopicolide and dichlobenil.

Cancer Dietary (Food and Drinking Water) Exposure Results and
Characterization

BAM is formally unclassified with respect to cancer.  The parent
fungicide fluopicolide is classified as “not likely to be carcinogenic
to humans.”  The parent herbicide dichlobenil is classified as
“Group C, possible human carcinogen” with the RfD approach utilized
for quantification of human risk. The quantification of cancer risk
using the RfD approach is identical to the assessment for chronic
effects; no separate carcinogenic risk assessment is necessary. 

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL,
e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, ARIA is concerned when
estimated dietary risk exceeds 100% of the PAD.  ARIA is generally
concerned when estimated cancer risk exceeds one in one million (i.e.,
the risk exceeds 3 x 10-6).  References which discuss the acute and
chronic risk assessments in more detail are available on the
EPA/pesticides web site:  “Available Information on Assessing Exposure
from Pesticides, A User’s Guide,” 21/JUN/2000, web link:   
HYPERLINK "http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/ Day
-12/6061.pdf"  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/ Day
-12/6061.pdf  ; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for BAM was conducted by N.Dodd
(21-NOV-07, D340366).

II.	Residue Information

BAM is a metabolite and/or environmental degradate of both fluopicolide
and dichlobenil.  This risk assessment includes residues of BAM in food
and drinking water from uses of both fluopicolide and dichlobenil.  A
separate assessment (D349721, S.Piper, 19-MAR-08) has been conducted for
fluopicolide (parent) and a separate assessment (D341453, D.Rate, in
process) is being conducted concurrently for dichlobenil (parent).   

Fluopicolide

Tolerances have been established (40 CFR §180.627) for residues of
fluopicolide,
2,6-dichloro-N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]
benzamide, range from 0.02 ppm on vegetable, tuberous and corm (except
potato) to 6.0 ppm for use on grape raisins as an imported crops.  No
livestock tolerances have been established.  

Dichlobenil

Dichlobenil is registered as a granular (G) formulation (Casoron® 4G;
EPA Reg. No. 400-168; date of issuance: 18-MAY-05) for use on apple,
blueberry, cherry, filbert, grape, and pear at 6 lb ai/A/season and on
blackberry, cranberry, and raspberry at 4 lb ai/A/season.  A
registration for Casoron® 4G for use on rhubarb at 2 lb ai/A/season and
translation of data to establish tolerances on berry commodities are
pending (D315266, W.Cutchin, 22-FEB-06 and D349398, D.Rate, in process).

Tolerances are established (40 CFR §180.231) for the herbicide
dichlobenil (2,6-dichlorobenzonitrile) and its metabolite
2,6-dichlorobenzamide.  A tolerance for rhubarb and tolerances on berry
commodities translated from the data reviewed for tolerances on
blueberry, blackberry and raspberry are pending.  The revised RED
(31-JUL-1996) recommended deletion of the stone fruit crop group
tolerance which was not being supported by the petitioner and
establishment of a separate tolerance on cherries.  However, the stone
fruit crop group is included in this dietary exposure assessment since
commodities containing BAM residues could be imported as long as the
tolerance exists [as stated in the previous RED:  Kathryn Boyle,
31-JUL-1996:  Dichlobenil: The Revised HED Chapter of the Reregistration
Eligibility Decision Document (RED), Case 0263, Chemical 027401, 027402
(BAM)].  No livestock tolerances are established for dichlobenil.  Since
the potato use will not be registered at this time and some restrictions
will be applied to rotational crops at this time, no livestock feed
items are associated with this petition.

Residue Data used for Acute and Chronic Assessments:

Maximum residues of BAM from fluopicolide field trials were used on root
vegetables, leaves of root and tuber vegetables, bulb vegetables, and
head and stem Brassica and from dichlobenil field trials on rhubarb,
caneberries, bushberries and associated berry commodities.  The
assessments used 100% crop treated except for apples, blueberries,
cherries, cranberries, peaches, pears, and raspberries (See attachment
6).  Tolerances for grape have been established for imported grapes;
therefore, no percent crop treated was used.  No livestock tolerances
are established or proposed for either fluopicolide or dichlobenil. DEEM
(version 7.81) default processing factors were used.  A summary of the
anticipated residues for the new uses are listed in Table 1 below.

Table 1. Residue Estimates Used in the BAM Dietary Analysis

RAC	Classification1	Data Source	No. of Samples	Acute

% CT2	Chronic

 % CT2	Processing Factors	Acute & Chronic (Maximum Residues ppm)

Amaranth, leafy	PB	MRID 46708540 (spinach)	14	100	100

0.188

Apple	NB/PB	MRID 42177102	15	2.5	1.0	8.0 dried

1.3 juice	RDF 1

0.271

Apricot5	NB/PB	MRID 42476102 (peach)	6	100	100	6.0 dried	0.04

Arrowroot, flour	NB	MRID 46708537	38	100	100

0.01

Artichoke	NB	MRID 46708537	38	100	100

0.01

Arugula	PB	MRID 46708540 (spinach)	14	100	100

0.188

Balsam, pear	NB	MRID 46708531 (cantaloupe)	18	100	100

0.01

Beet garden, roots	NB/PB	MRID 47021704 (radish roots)	12	100	100

0.01

Beet garden, tops	PB	MRID 47021704 (radish tops)	12	100	100

0.163

Blackberry	PB	MRID 42452803	3	100	100

0.01

Blueberry	PB	MRID 42304201	3	2.5	1.0

RDF 2

0.06

Boysenberry3	PB	MRID 42452803

(blackberry)	3	100	100

0.01

Broccoli	NB/PB	MRID 47021701	12	100	100

0.01

Brussels sprouts	PB	MRID 47021701 (cabbage)	14	100	100

0.017

Burdock	NB	MRID 4702170

(radish tops)	12	100	100

0.01

Cabbage	NB/PB	MRID 47021701	14	100	100

0.017

Cantaloupe	NB/PB	MRID 46708531	18	100	100

0.01

Cardoon	NB/PB	MRID 46708539

(celery)	12	100	100

0.041

Casaba	NB	MRID 46708531

(cantaloupe)	18	100	100

0.01

Cassava	NB/PB	MRID 47021704 (radish roots)	12	100	100

0.01

Cauliflower	NB/PB	MRID 47021701 (broccoli)	12	100	100

0.01

Celeriac	NB	MRID 47021704

(radish tops)	12	100	100

0.01

Celery	NB/PB	MRID 46708539	12	100	100

0.041

Chayote	NB	MRID 46708538

(squash)	12	100	100

0.01

Cherry	PB	MRID 42452804	2	2.5	1.0	1.5 juice	RDF 3

0.46

Chicory, roots	NB	MRID 47021704

(radish roots)	12	100	100

0.01

Chicory, tops	NB	MRID 47021704 (radish tops)	12	100	100

0.163

Chinese waxgourd	NB/PB	MRID 46708532

(cucumber)	12	100	100

0.01

Chive	B	MRID 47021703 (green onion)	6	100	100

0.014

Chrysanthemum, garland	PB	MRID 46708540 (spinach)	14	100	100

0.188

Cranberry	PB	MRID 42452801

100	45	1.1 juice	0.03

Cress	PB	MRID 46708540 (spinach)	14	100	100

0.188

Cucumber	NB/PB	MRID 46708532	12	100	100

0.01

Currant	PB	MRID 42304201 (blueberry)	3	2.5	1.0

0.06

Dandelion	PB	MRID 46708540 (spinach)	14	100	100

0.188

Dasheen corm	PB	MRID 47021704 (radish tops)	12	100	100

0.01

Dasheen leaves	PB	MRID 47021704 (radish roots)	12	100	100

0.163

Dewberry	PB	MRID 42452803 (blackberry)	3	100	100

0.01

Eggplant	NB	MRID 46708530 (pepper)	14	100	100

0.01

Elderberry4	PB	MRID 42304201

(blueberry)	3	100	100

0.06

Endive	PB	MRID 46708540 (spinach)	14	100	100

0.188

Fennel Florence	B	MRID 46708539 (celery)	12	100	100

0.041

Filbert6	PB	MRID 42476101	3	100	100

0.02

Garlic	NB/PB	MRID 47021703 (green onion)	6	100	100

0.014

Ginger	NB	MRID 47021704 (radish roots)	12	100	100

0.01

Ginseng	PB	MRID 47021704 (radish tops)	12	100	100

0.01

Gooseberry4	PB	MRID 42304201 (blueberry)	3	100	100

0.06

Grape	PB	MRID 42476103	12	100	100	4.3 raisin

1.2 juice	0.1

Honeydew Melon	NB	MRID 46708531 (cantaloupe)	18	100	100

0.01

Horseradish	NB/PB	MRID 47021704 (radish roots)	12	100	100

0.01

Huckleberry	PB	MRID 42304201 (blueberry)	3	2.5	1.0

0.06

Kohlrabi	NB	MRID 47021701 (cabbage)	14	100	100

0.017

Leek	NB	MRID 47021703 (green onion)	6	100	100

0.014

Lettuce, head	NB/PB	MRID 46708533	14	100	100

0.0132

Lettuce, leaf	NB/PB	MRID 46708534	14	100	100

0.038

Loganberry	PB	MRID 42452803 (blackberry)	3	100	100

0.01

Nectarine5	NB	MRID 42476102 (peach)	6	100	100

0.04

Okra	NB/PB	MRID 46708530 (pepper)	14	100	100

0.01

Onion, bulb	NB/PB/B	MRID 47021703	14	100	100	 9.0 dried	0.01

Onion, green	PB	MRID 47021703	6	100	100

0.014

Parsley, leaves	PB	MRID 46708540 (spinach)	14	100	100

0.188

Parsley, root	NB	MRID 47021704 (radish roots)	12	100	100

0.01

Parsnip	NB	MRID 47021704 (radish roots)	12	100	100

0.01

Peach	NB/PB	MRID 42476102	6	2.5	1.0	7.0 dried

1.5 juice	RDF 4

0.04

Pear	NB/PB	MRID 42177102 (apple)	15	2.5	1.0	6.25 dried	RDF 1

0.271

Pepper	NB/PB	MRID 46708530	14	100	100

0.01

Plum	NB/PB	MRID 42452804	2	100	100	5.0 prune dried

1.4 juice	0.46

Pumpkin	NB/PB	MRID 46708531 (cantaloupe)	18	100	100

0.01

Radicchio	NB	MRID 46708533 (lettuce)	14	100	100

0.0132

Radish, root	PB	MRID 47021704	12	100	100

0.01

Radish, tops	PB	MRID 47021704	12	100	100

0.163

Raspberry	PB	MRID 42452803 (blackberry)	3	5.0	5.0

RDF 5

70.01

Rhubarb	NB	MRID 46708539 (celery)	12	100	100

0.041

Rutabaga	NB/PB	MRID 47021704 (radish roots)	12	100	100

0.01

Salisfy, roots	NB	MRID 47021704 (radish roots)	12	100	100

0.01

Salisfy, tops	NB	MRID 47021704 (radish tops)	12	100	100

0.163

Shallot	NB	MRID 47021703 (green onion)	6	100	100

0.014

Spinach	PB	MRID 46708540	14	100	100

0.188

Squash	NB/PB	MRID 46708538	12	100	100

0.01

Sweet Potato	NB/PB	MRID 47021704 (radish roots)	12	100	100

0.01

Swiss Chard	NB	MRID 46708539 (celery)	12	100	100

0.041

Tomatillo	NB	MRID 46708536 (tomato)	24	100	100

0.01

Tomato	NB/PB	MRID 46708536	24	100	100	5.4 paste

3.3 puree

14.3 dried

1.5 juice	0.01

Turmeric	NB	MRID 47021704 (radish roots)	12	100	100

0.01

Turnip, roots	NB/PB	MRID 47021704 (radish roots)	12	100	100

0.01

Water	--

	--	--

0.0562

Watermelon	NB/PB	MRID 46708531 (cantaloupe)	18	100	100

0.01

Yam	NB	MRID 47021704 (radish roots)	12	100	100

0.01

1 B=Blended; PB=Partially Blended; NB=Not Blended

2 Percent crop treated data were provided by the Biological and Economic
Analysis Division (DP Num: 342741, J. Alsadek, Ph.D., 22-AUG-2007). 
“Percent of Crop Treated” values were used for the chronic
assessment; “Maximum Percent of Crop Treated” values were used for
the acute assessment. 

3 Blackberry residue was translated to and used in the dietary analysis
for caneberry, subgroup 13A and wild raspberry.  

4 Blueberry residue was translated to and used in the dietary analysis
for bushberry, Subgroup 13B.

5 Peach residue was translated to apricot and nectarine. [HED SOP 200.1:
 Guidance for Translation of Field Trial Data from Representative
Commodities in the Crop Group Regulation to Other Commodities in Each
Crop Group/Subgroup, HED Standard Operating Procedure (12-SEP-2000)].  

6 Filberts, the highest reported residue was doubled to 0.02 because of
approximately 50% degradation on storage. 

III. Drinking Water Data

As discussed below, the drinking water residue level used in this
dietary risk assessment is the estimate of residues of BAM from use of
dichlobenil.  This residue level was the highest, considering uses of
dichlobenil, uses of fluopicolide, and uses of both fluopicolide and
dichlobenil (on grapes and rhubarb, the only crops on which both
pesticides will be registered).  This assessment will use 56.2 ppb (from
SCIGROW modeling of BAM residues from dichlobenil use on nutsedge) for
the drinking water estimate for both the acute and chronic exposures.

Dichlobenil

The BAM residues in drinking water from use of dichlobenil were provided
by the Environmental Fate and Effects Division (EFED) in the following
memoranda:  “Drinking Water Assessment for the BAM
(2,6-Dichlorobenzamide) Degradate of Dichlobenil” (DP Num: 340773, J.
Angier, Ph.D., 29-AUG-2007).  The sums of the reported values were
incorporated directly into this dietary assessment.  Water residues were
incorporated in the DEEM-FCID into the food categories “water, direct,
all sources” and “water, indirect, all sources.” 

This drinking water exposure assessment utilizes known physical/chemical
characteristics of BAM, combined with estimated rates of formation of
the degradate following dichlobenil application.  The OPP/EFED Tier 2
surface water model PRZM-EXAMS (Pesticide Root Zone Model - Exposure
Analysis Modeling System) was used in this assessment.  Percent Cropped
Area (PCA) corrections were applied for appropriate crops as well. 
Currently registered and pending uses of dichlobenil were considered. 
Dichlobenil use is currently registered for control of weeds in fruit
and nut orchards (6 lbs ai/acre) and non-crop areas (12 lbs ai/acre),
and for control of nutsedge (10 lbs ai/acre).  (Nutsedge usage was
previously evaluated at 20 lbs ai/acre; the current label restricts this
use to a maximum application rate of 10 lbs ai/acre.)  A new use on
rhubarb (2 lbs ai/acre) is pending.  A screening assessment for the
impact of BAM on potential groundwater drinking water sources, using the
Tier 1 groundwater model SCIGROW, has also been conducted.

 

Each run was performed using fate and mobility parameters for BAM only. 
To determine the equivalent amount of BAM degradate applied as a result
of dichlobenil usage, the ‘applied’ BAM amounts were calculated by
multiplying the maximum amount of BAM expected to form as a result of
registered dichlobenil use (13.1%) by the (maximum allowed for each
scenario) amounts of dichlobenil applied.  However, since BAM has a
different molecular weight (190.3 g/mol) than parent dichlobenil (172
g/L), a further correction was applied.  Thus, in terms of total mass,
BAM represents 14.5% of parent dichlobenil.  Rhubarb and orchard values
have had PCA adjustments of 87% applied, while the nutsedge control and
other non-crop uses have no PCA applied.

SURFACE WATER DRINKING WATER CONCENTRATIONS (ppb) FOR THE DEGRADATE BAM
(RESULTING FROM DICHLOBENIL USE), MODELED USING PRZM-EXAMS

Scenario	Peak (acute)		1-in-10 Year Annual Mean		30 Year Overall Mean

FL turf (Nutsedge control):

20.9				8.61					3.97

CA lettuce (surrogate for Rhubarb):	

		12.9				6.59					3.69

FL turf (non-crop weed control):

		25.5				10.5					4.84

OR apple (Orchards):

		6.13				3.63					0.896

Results for estimated (high-end) groundwater BAM concentrations from
SCIGROW were obtained using the maximum proposed application rates
(adjusted to reflect 14.5% of applied dichlobenil) and the available
fate parameters for BAM.  

GROUND WATER DRINKING WATER CONCENTRATIONS FOR BAM, RESULTING FROM
PARENT DICHLOBENIL USE – MODELED USING SCIGROW

SciGrow output for Nutsedge control use = 56.2 ppb

SciGrow output for non-crop weed control use = 67.4 ppb

SciGrow output for Orchard use = 33.7 ppb

SciGrow output for Rhubarb use = 11.2 ppb

Since the weed control in non-crop areas is typically applied beneath a
semi-protective layer such as concrete, vinyl liner, etc., it is not
expected to contribute substantially to runoff or infiltration (as the
covering will restrict contact with water).  Thus, for “non crop area
weed control” only, the EECs are not truly representative of what
would be expected under approved usage patterns (e.g., under concrete,
asphalt, etc). 

 

Based on modeling results, the estimated ground water drinking water
concentration for BAM from use of dichlobenil is 56.2 ppb (based on
SCIGROW modeling of dichlobenil use on nutsedge).  (The use for non-crop
weed control is not expected to exceed the use for nutsedge control on
an actual use basis.)  This BAM residue level is higher than estimated
residues in surface water.

Fluopicolide

The BAM residues in drinking water from use of fluopicolide were
provided by the EFED in the following memoranda: “Drinking Water
Exposure Assessment for Fluopicolide Uses on Grapes, Vegetables,
Potatoes, Sugar Beet, Onion, and Turf – Exposure of
2,6-Dichlorobenzamide (BAM) (DP Number 325804, J. Lin, 3-MAY-07).

This drinking water exposure memo addresses the human exposure of BAM
through ingestion of drinking water from uses of fluopicolide on grapes,
vegetables, sugar beet, onion and turf.  The drinking water exposure of
fluopicolide itself has been addressed in an earlier drinking water
exposure memo (07/MAR/2007).  Surface water concentrations were
estimated using the Tier II model PRZM version 3.12 and EXAMS version
2.98.  Ground water concentrations were estimated using the Tier I
SCI-GROW model. 

Based on modeling results, the estimated surface water drinking water
concentrations for BAM from uses of fluopicolide are:  

4.26 ug /L for the 1-in-10 year annual peak concentration (acute)  

1.53 ug /L for the 1-in-10 year annual mean concentration (non-cancer
chronic) and  

0.85 ug /L for the 30-year annual mean concentration (cancer chronic).  

The 1-in-10 year annual peak (acute) was derived from modeling on
Florida peppers.  The 1-in-10 year annual mean (non-cancer chronic) and
the 30-year annual mean concentration (cancer chronic) were derived from
modeling on California lettuce.  These values were highest among all
modeling scenarios examined.  

The SCI-GROW estimated ground water drinking water concentrations for
BAM form uses of fluopicolide are not expected to exceed 4.19 μg/L,
which was based on 2 applications of 0.054 lb ai/A per application.

Dichlobenil and Fluopicolide

Grapes and rhubarb (a leafy vegetable) are the only crops on which both
dichlobenil and fluopicolide are to be registered.  The rates on grapes
are 2 lb ai/A for dichlobenil and 0.375 lb ai/A for fluopicolide.  The
rates on rhubarb are also 2 lb ai/A for dichlobenil and 0.375 lb ai/A
for fluopicolide.  Since the rate for dichlobenil on nutsedge is much
higher (10 lb ai/A), the dichlobenil use on nutsedge is expected to
result in higher residues in drinking water.

IV.	DEEM-FCID™ Program and Consumption Information

BAM acute and chronic dietary exposure assessments were conducted using
the Dietary Exposure Evaluation Model software with the Food Commodity
Intake Database DEEM-FCID™, Version 2.03, which incorporates
consumption data from USDA’s Continuing Surveys of Food Intakes by
Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98 data are based
on the reported consumption of more than 20,000 individuals over two
non-consecutive survey days.  Foods “as consumed” (e.g., apple pie)
are linked to EPA-defined food commodities (e.g. apples, peeled fruit -
cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S,
baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA.  For chronic exposure assessment,
consumption data are averaged for the entire U.S. population and within
population subgroups, but for acute exposure assessment are retained as
individual consumption events.  Based on analysis of the 1994-96, 98
CSFII consumption data, which took into account dietary patterns and
survey respondents, HED concluded that it is most appropriate to report
risk for the following population subgroups: the general U.S.
population, all infants (<1 year old), children 1-2, children 3-5,
children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+
years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., only those who reported
eating relevant commodities/food forms) and a per-capita (i.e., those
who reported eating the relevant commodities as well as those who did
not) basis.  In accordance with HED policy, per capita exposure and risk
are reported for all tiers of analysis.  However, for highly refined
assessments, any significant differences in user vs. per capita exposure
and risk are specifically identified and noted in the risk assessment.

V.	Toxicological Information

BAM toxicity was reassessed (R. Mitkus, RAB1, updated 09-AUG-07) as
follows:

Table 2.  Summary of Toxicological Doses and Endpoints for
2,6-Dichlorobenzamide (BAM) for Use in Dietary Exposure Assessments

Exposure Scenario	Point of Departure	Uncertainty/

FQPA Safety Factors	RfD, PAD, Level of Concern for Risk Assessment	Study
and Toxicological Effects

Acute Dietary (General population, including infants and children)	LOAEL
= 100 mg/kg/day 

	UFA = 10X

UFH = 10X

FQPA SF1,2 = 10X (includes UFL and UFDB)

	aRfD = aPAD = 0.1 mg/kg/day	Dose-range finding assay for in vivo mouse
erythrocyte micronucleus assay LOAEL = 100 mg/kg/day based on lethargy
after a single oral dose

Acute Dietary (Females 13-49 years of age)	NOAEL = 30 mg/kg/day	UFA =
10X

UFH = 10X

FQPA SF1 = 10X

(includes UFDB)	aRfD = aPAD = 0.03 mg/kg/day	Developmental toxicity
(rabbit) Offspring LOAEL = 90 mg/kg/day based on increased incidences of
 late abortion and skeletal (bipartite interparietal bone) and visceral
(postcaval lung lobe agenesis) anomalies

Chronic Dietary (All populations)	NOAEL = 4.5

mg/kg/day	UFA = 10X

UFH = 10X

FQPA SF1 = 10X

(includes UFDB)	cRfD = cPAD = 0.0045 mg/kg/day	Chronic toxicity (dog)
LOAEL = 12.5 mg/kg/day based on decreased body weight and body weight
gain

Cancer	Classification: Formally unclassified.  The parent herbicide
dichlobenil is classified as “Group C, possible human carcinogen”
with RfD approach utilized for quantification of human risk.  The parent
fungicide fluopicolide is “not likely to be carcinogenic to humans.”

Abbreviations: UF = uncertainty factor, UFA = extrapolation from animal
to human (interspecies), UFH = potential variation in sensitivity among
members of the human population (intraspecies), FQPA SF = FQPA Safety
Factor, UFL = use of a LOAEL to extrapolate a NOAEL, UFDB = to account
for the absence of key data, NOAEL = no observed adverse effect level,
LOAEL = lowest observed adverse effect level, RfD = reference dose (a =
acute, c = chronic), PAD = population adjusted dose, MOE = margin of
exposure, 

1 The FQPA SF has been retained in the form of a UFDB for the lack of
neurotoxicity, including olfactory toxicity, data.

2 The FQPA SF has been retained in the form of a UFL and UFDB for the
use of a LOAEL to extrapolate a NOAEL and for the lack of olfactory
toxicity data.

VI.	Results/Discussion 

As stated above, for acute and chronic assessments, the Agency is
concerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID™
analyses estimate the dietary exposure of the U.S. population and
various population subgroups.  The results reported in Tables 3 and 4
are for the general U.S. Population, all infants (<1 year old), children
1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults
20-49, and adults 50+ years.  Cancer risk is determined for the general
U.S. population only.

Results of Acute and Chronic Dietary (Food and Drinking Water) Exposure
Analyses

The results of the acute dietary exposure analysis are reported in Table
3, below.  A conservative acute and chronic (food and drinking water)
exposure assessments were conducted.  Maximum residues of BAM from
fluopicolide field trials on root vegetables, leaves of root and tuber
vegetables, bulb vegetables, and head and stem Brassica, and from
dichlobenil field trials on food commodities with established/pending
tolerances (40 CFR 180.231) were included in the assessments.  The
assessments used 100% crop treated except for apples, blueberries,
cherries, cranberries, peaches, pears, and raspberries.  No livestock
tolerances are established or proposed for either fluopicolide or
dichlobenil.  DEEM default processing factors were used.

The drinking water residue level used in this dietary risk assessment is
the estimate of residues of BAM from use of dichlobenil.  This
assessment will use 56.2 ppb (from SCIGROW modeling of BAM residues from
dichlobenil use on nutsedge) for the drinking water estimate for both
the acute and chronic exposures.

The results of the acute dietary analysis for food and drinking water
indicate that acute dietary risks do not exceed the Agency’s level of
concern (<100% of the aPAD) for the U.S. population and all subgroups. 
Combined dietary from food and drinking water at the 99.9th percentile
of exposure is estimated to be 0.011650 mg/kg/day for the overall U.S.
population, equivalent to 12% of the aPAD.  The population subgroup with
the highest estimated acute dietary exposure are all infants (<1 year
old) of 0.028470 mg/kg/day, equivalent to 28% of the aPAD.

Table 3.  Results of Acute Dietary for Food and Water using DEEM-FCID 

Population Subgroup	aPAD (mg/kg/day)	95th Percentile	99th Percentile
99.9th Percentile

Exposure (mg/kg/day)	% aPAD	Exposure (mg/kg/day)	% aPAD	Exposure
(mg/kg/day)	% aPAD

General U.S. Population	0.1	0.003294	3	0.005997	6	0.011650	12

All Infants (< 1 year old)

0.011506	12	0.016406	16	0.028470	28

Children 1-2 years old

0.005949	6	0.009911	10	0.017320	17

Children 3-5 years old

0.005021	5	0.007521	8	0.014934	15

Children 6-12 years old

0.003314	3	0.005349	5	0.008285	8

Youth 13-19 years old

0.002576	3	0.004146	4	0.007207	7

Adults 20-49 years old

0.002886	3	0.004726	5	0.008394	8

Adults 50+ years old

0.002726	3	0.003983	4	0.006591	7

Females 13-49 years old	0.03	0.002926	10	0.004720	16	0.008495	28

As shown in Table 4, chronic dietary exposure estimates for food and
drinking water are well below HED’s level of concern (<100% cPAD) for
all population subgroups.  The dietary exposure is estimated at 0.001317
mg/kg/day for the general U.S. population (29% of the cPAD) and 0.004170
mg/kg/day (93% of the cPAD) for infants (<1 year old), the population
subgroup with the highest estimated chronic dietary exposure to BAM from
fluopicolide and dichlobenil.

Table 4.  Summary of Dietary (Food and Drinking Water) Exposure and Risk
for BAM

Population Subgroup	Acute Dietary

(99.9th Percentile)	Chronic Dietary	Cancer

	Dietary Exposure (mg/kg/day)	% aPAD	Dietary Exposure

(mg/kg/day)	% cPAD	Dietary Exposure

(mg/kg/day)	Risk

General U.S. Population	0.011650	11	0.001317	29	*	*

All Infants (< 1 year old)	0.028470	28	0.004170	93	N/A	N/A

Children 1-2 years old	0.017320	17	0.002284	51

Children 3-5 years old	0.014934	12	0.001985	44

Children 6-12 years old	0.008285	7	0.001297	29

Youth 13-19 years old	0.007207	7	0.000930	21

Adults 20-49 years old	0.008394	8	0.001196	27

Adults 50+ years old	0.006591	7	0.001288	29

Females 13-49 years old	0.008495	28	0.001196	27

* Classification: BAM is formally unclassified.  The parent herbicide
dichlobenil is classified as “Group C, possible human carcinogen”
with RfD approach utilized for quantification of human risk.  The
quantification of cancer risk using the RfD approach is identical to the
assessment for chronic effects; no separate carcinogenic risk assessment
is necessary.   The parent fungicide fluopicolide is “not likely to be
carcinogenic to humans.”

VII.	Characterization of Inputs/Outputs

Conservative acute and chronic (food and drinking water) exposure
assessments were conducted.  Maximum residues of BAM from fluopicolide
field trials on imported grapes and from dichlobenil field trials on
food commodities with established/pending tolerances (40 CFR 180.231)
were included in the assessment.  The assessments used 100% crop treated
except for apples, blueberries, cherries, cranberries, peaches, pears,
and raspberries.  No livestock tolerances are established or proposed
for either fluopicolide or dichlobenil.  DEEM default processing factors
were used.  Although not needed at this time, HED could refine the
exposure and risk assessments with the following information:  1)
additional projected market share/percent crop treated data; 2)
anticipated residue data; and 3) processing studies.

 

VIII.	Conclusions

	

The results of the acute dietary analysis for food and drinking water
indicate that acute dietary risks do not exceed the Agency’s level of
concern (<100% of the aPAD) for the U.S. population and all subgroups. 
Combined dietary from food and drinking water at the 99.9th percentile
of exposure is estimated to be 0.011650 mg/kg/day for the overall U.S.
population, equivalent to 12% of the aPAD.  The population subgroup with
the highest estimated acute dietary exposure are all infants (<1 year
old) of 0.028470 mg/kg/day, equivalent to 28% of the aPAD.

The results of the chronic dietary exposure estimates for food and
drinking water are well below HED’s level of concern (<100% cPAD) for
all population subgroups.  The dietary exposure is estimated at 0.001317
mg/kg/day for the general U.S. population (29% of the cPAD) and 0.004170
mg/kg/day (93% of the cPAD) for infants (<1 year old), the population
subgroup with the highest estimated chronic dietary exposure to BAM from
fluopicolide and dichlobenil.

 

 

IX.		List of Attachments

1.  Residue Distribution Files for the Acute Analyses

2.  Acute Food Plus Water Residue Input File 

3.  Acute Food Plus Water Results File

4.  Chronic Food Plus Water Residue Input File

5.  Chronic Food Plus Water Results File

6.  Screening Level Estimates of Agricultural Uses of Dichlobenil

Attachment 1:  Residue Distribution Files for the Acute Analyses 

RDF #1

'Apple, maximum res FT data; 2.5%CT 

TOTALZ=39

TOTALNZ=1

0.271	RDF #2

'Blueberry, maximum res FT data; 2.5%CT 

TOTALZ=39

TOTALNZ=1

0.06

RDF#3

'Cherry, maximum res FT data; 2.5%CT 

TOTALZ=39

TOTALNZ=1

0.46	RDF#4

'Peach, maximum res FT data; 2.5%CT 

TOTALZ=39

TOTALNZ=1

0.04

RDF#5

'Raspberry, maximum res FT data; 5%CT 

TOTALZ=19

TOTALNZ=1

0.01

	Attachment 2:  Acute Food plus Water Residue Input File

U.S. Environmental Protection Agency                                
Ver. 2.02

DEEM-FCID Acute analysis for 2,6-DICHLOROBENZAMIDE (BAM)

Residue file name: C:\DEEMFCID\BAM\BAM_domestic_acutePP7E7172R98.R98

Analysis Date 03-18-2008             Residue file dated:
03-18-2008/11:39:42/8

Reference dose (aRfD) = 0.1 mg/kg bw/day

Comment: New uses from PP#7E7172 + dichlobenil

------------------------------------------------------------------------
--------

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1           Param #2    Param #3    Comment

  #   Code 

----- ---- ------------           ----------- ----------- ----------

  1    6   apple.RDF

  2    6   blueberry.RDF

  3    6   Cherry.RDF

  4    6   Peach.RDF

  5    6   Raspberry.RDF

  EPA    Crop Food Name                         Def Res     Adj.Factors 
RDL  Comment

  Code    Grp                                    (ppm)       #1     #2  
Pntr

-------- ---- -------------------------------  ----------  ------ ------
---  -------

04010050 4A   Amaranth, leafy                    0.188000   1.000  1.000
     

11000070 11   Apple, fruit with peel             0.271000   1.000  1.000
  1  

11000080 11   Apple, peeled fruit                0.271000   1.000  1.000
  1  

11000081 11   Apple, peeled fruit-babyfood       0.271000   1.000  1.000
  1  

11000090 11   Apple, dried                       0.271000   8.000  1.000
     

11000091 11   Apple, dried-babyfood              0.271000   8.000  1.000
     

11000100 11   Apple, juice                       0.271000   1.300  1.000
  1  

11000101 11   Apple, juice-babyfood              0.271000   1.300  1.000
  1  

11000110 11   Apple, sauce                       0.271000   1.000  1.000
  1  

11000111 11   Apple, sauce-babyfood              0.271000   1.000  1.000
  1  

12000120 12   Apricot                            0.040000   1.000  1.000
     

12000121 12   Apricot-babyfood                   0.040000   1.000  1.000
     

12000130 12   Apricot, dried                     0.040000   6.000  1.000
     

12000140 12   Apricot, juice                     0.040000   1.000  1.000
     

12000141 12   Apricot, juice-babyfood            0.040000   1.000  1.000
     

01030150 1CD  Arrowroot, flour                   0.010000   1.000  1.000
     

01030151 1CD  Arrowroot, flour-babyfood          0.010000   1.000  1.000
     

01030170 1CD  Artichoke, Jerusalem               0.010000   1.000  1.000
     

04010180 4A   Arugula                            0.188000   1.000  1.000
     

09020210 9B   Balsam pear                        0.010000   1.000  1.000
     

01010500 1AB  Beet, garden, roots                0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

01010501 1AB  Beet, garden, roots-babyfood       0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

02000510 2    Beet, garden, tops                 0.163000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

13010550 13A  Blackberry                         0.010000   1.000  1.000
     

13010560 13A  Blackberry, juice                  0.010000   1.000  1.000
     

13010561 13A  Blackberry, juice-babyfood         0.010000   1.000  1.000
     

13020570 13B  Blueberry                          0.060000   1.000  1.000
  2  

13020571 13B  Blueberry-babyfood                 0.060000   1.000  1.000
  2  

13010580 13A  Boysenberry                        0.010000   1.000  1.000
     dichlo

    Full comment: dichlobenil

05010610 5A   Broccoli                           0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

05010611 5A   Broccoli-babyfood                  0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

05010620 5A   Broccoli, Chinese                  0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

05010640 5A   Brussels sprouts                   0.017000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

01010670 1AB  Burdock                            0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

05010690 5A   Cabbage                            0.017000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

05010710 5A   Cabbage, Chinese, napa             0.017000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

05010720 5A   Cabbage, Chinese, mustard          0.017000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

09010750 9A   Cantaloupe                         0.010000   1.000  1.000
     

04020760 4B   Cardoon                            0.041000   1.000  1.000
     

09010800 9A   Casaba                             0.010000   1.000  1.000
     

01030820 1CD  Cassava                            0.010000   1.000  1.000
     

01030821 1CD  Cassava-babyfood                   0.010000   1.000  1.000
     

05010830 5A   Cauliflower                        0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

01010840 1AB  Celeriac                           0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

04020850 4B   Celery                             0.041000   1.000  1.000
     

04020851 4B   Celery-babyfood                    0.041000   1.000  1.000
     

04020860 4B   Celery, juice                      0.041000   1.000  1.000
     

04020870 4B   Celtuce                            0.041000   1.000  1.000
     

09020880 9B   Chayote, fruit                     0.010000   1.000  1.000
     

12000900 12   Cherry                             0.460000   1.000  1.000
  3  

12000901 12   Cherry-babyfood                    0.460000   1.000  1.000
  3  

12000910 12   Cherry, juice                      0.460000   1.500  1.000
  3  

12000911 12   Cherry, juice-babyfood             0.460000   1.500  1.000
  3  

01011000 1AB  Chicory, roots                     0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

02001010 2    Chicory, tops                      0.163000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

09021020 9B   Chinese waxgourd                   0.010000   1.000  1.000
     

19011030 19A  Chive                              0.014000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

04011040 4A   Chrysanthemum, garland             0.188000   1.000  1.000
     

04011330 4A   Cress, garden                      0.188000   1.000  1.000
     

04011340 4A   Cress, upland                      0.188000   1.000  1.000
     

09021350 9B   Cucumber                           0.010000   1.000  1.000
     

13021360 13B  Currant                            0.060000   1.000  1.000
     dichlo

    Full comment: dichlobenil

13021370 13B  Currant, dried                     0.060000   1.000  1.000
     dichlo

    Full comment: dichlobenil

04011380 4A   Dandelion, leaves                  0.188000   1.000  1.000
     

01031390 1CD  Dasheen, corm                      0.010000   1.000  1.000
     

02001400 2    Dasheen, leaves                    0.163000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

13011420 13A  Dewberry                           0.010000   1.000  1.000
     dichlo

    Full comment: dichlobenil

08001480 8    Eggplant                           0.010000   1.000  1.000
     

13021490 13B  Elderberry                         0.060000   1.000  1.000
     dichlo

    Full comment: dichlobenil

04011500 4A   Endive                             0.188000   1.000  1.000
     

04021520 4B   Fennel, Florence                   0.041000   1.000  1.000
     

14001550 14   Filbert                            0.020000   1.000  1.000
     

14001560 14   Filbert, oil                       0.020000   1.000  1.000
     

03001640 3    Garlic                             0.014000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

03001650 3    Garlic, dried                      0.014000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

03001651 3    Garlic, dried-babyfood             0.014000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

01031660 1CD  Ginger                             0.010000   1.000  1.000
     

01031661 1CD  Ginger-babyfood                    0.010000   1.000  1.000
     

01031670 1CD  Ginger, dried                      0.010000   1.000  1.000
     

01011680 1AB  Ginseng, dried                     0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

13021740 13B  Gooseberry                         0.060000   1.000  1.000
     dichlo

    Full comment: dichlobenil

95001750 O    Grape                              0.100000   1.000  1.000
     

95001760 O    Grape, juice                       0.100000   1.200  1.000
     

95001761 O    Grape, juice-babyfood              0.100000   1.200  1.000
     

95001770 O    Grape, leaves                      0.100000   1.000  1.000
     

95001780 O    Grape, raisin                      0.100000   4.300  1.000
     

95001790 O    Grape, wine and sherry             0.100000   1.200  1.000
     

09011870 9A   Honeydew melon                     0.010000   1.000  1.000
     

01011900 1AB  Horseradish                        0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

13021910 13B  Huckleberry                        0.060000   1.000  1.000
     dichlo

    Full comment: dichlobenil

05011960 5A   Kohlrabi                           0.017000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

03001980 3    Leek                               0.014000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

04012040 4A   Lettuce, head                      0.013200   1.000  1.000
     

04012050 4A   Lettuce, leaf                      0.038000   1.000  1.000
     

13012080 13A  Loganberry                         0.010000   1.000  1.000
     dichlo

    Full comment: dichlobenil

12002300 12   Nectarine                          0.040000   1.000  1.000
     

08002340 8    Okra                               0.010000   1.000  1.000
     

03002370 3    Onion, dry bulb                    0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

03002371 3    Onion, dry bulb-babyfood           0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

03002380 3    Onion, dry bulb, dried             0.010000   9.000  1.000
     PP#7E7

    Full comment: PP#7E7172

03002381 3    Onion, dry bulb, dried-babyfood    0.010000   9.000  1.000
     PP#7E7

    Full comment: PP#7E7172

03002390 3    Onion, green                       0.014000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

04012480 4A   Parsley, leaves                    0.188000   1.000  1.000
     

01012500 1AB  Parsley, turnip rooted             0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

01012510 1AB  Parsnip                            0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

01012511 1AB  Parsnip-babyfood                   0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

12002600 12   Peach                              0.040000   1.000  1.000
  4  

12002601 12   Peach-babyfood                     0.040000   1.000  1.000
  4  

12002610 12   Peach, dried                       0.040000   7.000  1.000
  4  

12002611 12   Peach, dried-babyfood              0.040000   7.000  1.000
  4  

12002620 12   Peach, juice                       0.040000   1.500  1.000
  4  

12002621 12   Peach, juice-babyfood              0.040000   1.500  1.000
  4  

11002660 11   Pear                               0.271000   1.000  1.000
  1  

11002661 11   Pear-babyfood                      0.271000   1.000  1.000
  1  

11002670 11   Pear, dried                        0.271000   6.250  1.000
  1  

11002680 11   Pear, juice                        0.271000   1.000  1.000
  1  

11002681 11   Pear, juice-babyfood               0.271000   1.000  1.000
  1  

08002700 8    Pepper, bell                       0.010000   1.000  1.000
     

08002701 8    Pepper, bell-babyfood              0.010000   1.000  1.000
     

08002710 8    Pepper, bell, dried                0.010000   1.000  1.000
     

08002711 8    Pepper, bell, dried-babyfood       0.010000   1.000  1.000
     

08002720 8    Pepper, nonbell                    0.010000   1.000  1.000
     

08002721 8    Pepper, nonbell-babyfood           0.010000   1.000  1.000
     

08002730 8    Pepper, nonbell, dried             0.010000   1.000  1.000
     

12002850 12   Plum                               0.460000   1.000  1.000
     

12002851 12   Plum-babyfood                      0.460000   1.000  1.000
     

12002860 12   Plum, prune, fresh                 0.460000   1.000  1.000
     

12002861 12   Plum, prune, fresh-babyfood        0.460000   1.000  1.000
     

12002870 12   Plum, prune, dried                 0.460000   5.000  1.000
     

12002871 12   Plum, prune, dried-babyfood        0.460000   5.000  1.000
     

12002880 12   Plum, prune, juice                 0.460000   1.400  1.000
     

12002881 12   Plum, prune, juice-babyfood        0.460000   1.400  1.000
     

09023080 9B   Pumpkin                            0.010000   1.000  1.000
     

09023090 9B   Pumpkin, seed                      0.010000   1.000  1.000
     

04013130 4A   Radicchio                          0.013200   1.000  1.000
     

01013140 1AB  Radish, roots                      0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

02003150 2    Radish, tops                       0.163000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

01013160 1AB  Radish, Oriental, roots            0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

02003170 2    Radish, Oriental, tops             0.163000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

13013200 13A  Raspberry                          0.010000   1.000  1.000
  5  dichlo

    Full comment: dichlobenil

13013201 13A  Raspberry-babyfood                 0.010000   1.000  1.000
  5  

13013210 13A  Raspberry, juice                   0.010000   1.000  1.000
  5  

13013211 13A  Raspberry, juice-babyfood          0.010000   1.000  1.000
  5  

04023220 4B   Rhubarb                            0.041000   1.000  1.000
     

01013270 1AB  Rutabaga                           0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

01013310 1AB  Salsify, roots                     0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

02003320 2    Salsify, tops                      0.163000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

03003380 3    Shallot                            0.014000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

04013550 4A   Spinach                            0.188000   1.000  1.000
     

04013551 4A   Spinach-babyfood                   0.188000   1.000  1.000
     

09023560 9B   Squash, summer                     0.010000   1.000  1.000
     

09023561 9B   Squash, summer-babyfood            0.010000   1.000  1.000
     

09023570 9B   Squash, winter                     0.010000   1.000  1.000
     

09023571 9B   Squash, winter-babyfood            0.010000   1.000  1.000
     

01033660 1CD  Sweet potato                       0.010000   1.000  1.000
     

01033661 1CD  Sweet potato-babyfood              0.010000   1.000  1.000
     

04023670 4B   Swiss chard                        0.041000   1.000  1.000
     

01033710 1CD  Tanier, corm                       0.010000   1.000  1.000
     

08003740 8    Tomatillo                          0.010000   1.000  1.000
     

08003750 8    Tomato                             0.010000   1.000  1.000
     

08003751 8    Tomato-babyfood                    0.010000   1.000  1.000
     

08003760 8    Tomato, paste                      0.010000   5.400  1.000
     

08003761 8    Tomato, paste-babyfood             0.010000   5.400  1.000
     

08003770 8    Tomato, puree                      0.010000   3.300  1.000
     

08003771 8    Tomato, puree-babyfood             0.010000   3.300  1.000
     

08003780 8    Tomato, dried                      0.010000  14.300  1.000
     

08003781 8    Tomato, dried-babyfood             0.010000  14.300  1.000
     

08003790 8    Tomato, juice                      0.010000   1.500  1.000
     

01033870 1CD  Turmeric                           0.010000   1.000  1.000
     

01013880 1AB  Turnip, roots                      0.010000   1.000  1.000
     PP#7E7

    Full comment: PP#7E7172

86010000 O    Water, direct, all sources         0.056200   1.000  1.000
     

86020000 O    Water, indirect, all sources       0.056200   1.000  1.000
     

09013990 9A   Watermelon                         0.010000   1.000  1.000
     

09014000 9A   Watermelon, juice                  0.010000   1.000  1.000
     

01034060 1CD  Yam, true                          0.010000   1.000  1.000
     

01034070 1CD  Yam bean                           0.010000   1.000  1.000
     

Attachment 3:  Acute Food Plus Water Results File

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for 2,6-DICHLOROBENZAMIDE (BAM)        
(1994-98 data)

Residue file: BAM_domestic_acutePP7E7172R98.R98       Adjustment factor
#2 used.

Analysis Date: 03-18-2008/12:05:12    Residue file dated:
03-18-2008/11:39:42/8

Acute Pop Adjusted Dose (aPAD) varies with population; see individual
reports

Daily totals for food and foodform consumption used.

MC iterations = 1000      MC list in residue file     MC seed = 10

Run Comment: "New uses from PP#7E7172 + dichlobenil"

========================================================================
=======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th
Percentile

                   Exposure   % aPAD    Exposure   % aPAD    Exposure  
% aPAD 

                  ---------- --------  ---------- --------  ----------
--------

U.S. Population:

                    0.003294     3.29    0.005997     6.00    0.011650  
 11.65 

All infants:

                    0.011506    11.51    0.016406    16.41    0.028470  
 28.47 

Children 1-2 yrs:

                    0.005949     5.95    0.009911     9.91    0.017320  
 17.32 

Children 3-5 yrs:

                    0.005021     5.02    0.007521     7.52    0.014934  
 14.93 

Children 6-12 yrs:

                    0.003314     3.31    0.005349     5.35    0.008285  
  8.28 

Youth 13-19 yrs:

                    0.002576     2.58    0.004146     4.15    0.007207  
  7.21 

Adults 20-49 yrs:

                    0.002886     2.89    0.004726     4.73    0.008394  
  8.39 

Adults 50+ yrs:

                    0.002726     2.73    0.003983     3.98    0.006591  
  6.59 

Females 13-49 yrs:

                    0.002926     9.75    0.004720    15.73    0.008495  
 28.32

Attachment 4:  Chronic Food Plus Water Residue Input File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for 2,6-DICHLOROBENZAMIDE (BAM)       
1994-98 data

Residue file: C:\DEEMFCID\BAM\BAM_domestic_chronicPP7E7271.R98 Adjust.
#2 used

Analysis Date 03-18-2008             Residue file dated:
03-18-2008/11:51:13/8

Reference dose (RfD) = 0.0045 mg/kg bw/day

Comment:New uses from PP#7E7172 + dichlobenil berries

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

04010050 4A   Amaranth, leafy                    0.188000   1.000     
1.000   

11000070 11   Apple, fruit with peel             0.271000   1.000     
0.010   

11000080 11   Apple, peeled fruit                0.271000   1.000     
0.010   

11000081 11   Apple, peeled fruit-babyfood       0.271000   1.000     
0.010   

11000090 11   Apple, dried                       0.271000   8.000     
0.010   

11000091 11   Apple, dried-babyfood              0.271000   8.000     
0.010   

11000100 11   Apple, juice                       0.271000   1.300     
0.010   

11000101 11   Apple, juice-babyfood              0.271000   1.300     
0.010   

11000110 11   Apple, sauce                       0.271000   1.000     
0.010   

11000111 11   Apple, sauce-babyfood              0.271000   1.000     
0.010   

12000120 12   Apricot                            0.040000   1.000     
1.000   

12000121 12   Apricot-babyfood                   0.040000   1.000     
1.000   

12000130 12   Apricot, dried                     0.040000   6.000     
1.000   

12000140 12   Apricot, juice                     0.040000   1.000     
1.000   

12000141 12   Apricot, juice-babyfood            0.040000   1.000     
1.000   

01030150 1CD  Arrowroot, flour                   0.010000   1.000     
1.000   

01030151 1CD  Arrowroot, flour-babyfood          0.010000   1.000     
1.000   

01030170 1CD  Artichoke, Jerusalem               0.010000   1.000     
1.000   

04010180 4A   Arugula                            0.188000   1.000     
1.000   

09020210 9B   Balsam pear                        0.010000   1.000     
1.000   

01010500 1AB  Beet, garden, roots                0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

01010501 1AB  Beet, garden, roots-babyfood       0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

02000510 2    Beet, garden, tops                 0.163000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

13010550 13A  Blackberry                         0.010000   1.000     
1.000   

13010560 13A  Blackberry, juice                  0.010000   1.000     
1.000   

13010561 13A  Blackberry, juice-babyfood         0.010000   1.000     
1.000   

13020570 13B  Blueberry                          0.060000   1.000     
0.010   

13020571 13B  Blueberry-babyfood                 0.060000   1.000     
0.010   

13010580 13A  Boysenberry                        0.010000   1.000     
1.000   dichlo

  Full comment: dichlobenil

05010610 5A   Broccoli                           0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

05010611 5A   Broccoli-babyfood                  0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

05010620 5A   Broccoli, Chinese                  0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

05010640 5A   Brussels sprouts                   0.017000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

01010670 1AB  Burdock                            0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

05010690 5A   Cabbage                            0.017000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

05010710 5A   Cabbage, Chinese, napa             0.017000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

05010720 5A   Cabbage, Chinese, mustard          0.017000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

09010750 9A   Cantaloupe                         0.010000   1.000     
1.000   

04020760 4B   Cardoon                            0.041000   1.000     
1.000   

09010800 9A   Casaba                             0.010000   1.000     
1.000   

01030820 1CD  Cassava                            0.010000   1.000     
1.000   

01030821 1CD  Cassava-babyfood                   0.010000   1.000     
1.000   

05010830 5A   Cauliflower                        0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

01010840 1AB  Celeriac                           0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

04020850 4B   Celery                             0.041000   1.000     
1.000   

04020851 4B   Celery-babyfood                    0.041000   1.000     
1.000   

04020860 4B   Celery, juice                      0.041000   1.000     
1.000   

04020870 4B   Celtuce                            0.041000   1.000     
1.000   

09020880 9B   Chayote, fruit                     0.010000   1.000     
1.000   

12000900 12   Cherry                             0.460000   1.000     
0.010   

12000901 12   Cherry-babyfood                    0.460000   1.000     
0.010   

12000910 12   Cherry, juice                      0.460000   1.500     
0.010   

12000911 12   Cherry, juice-babyfood             0.460000   1.500     
0.010   

01011000 1AB  Chicory, roots                     0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

02001010 2    Chicory, tops                      0.163000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

09021020 9B   Chinese waxgourd                   0.010000   1.000     
1.000   

19011030 19A  Chive                              0.014000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

04011040 4A   Chrysanthemum, garland             0.188000   1.000     
1.000   

04011330 4A   Cress, garden                      0.188000   1.000     
1.000   

04011340 4A   Cress, upland                      0.188000   1.000     
1.000   

09021350 9B   Cucumber                           0.010000   1.000     
1.000   

13021360 13B  Currant                            0.060000   1.000     
1.000   dichlo

  Full comment: dichlobenil

13021370 13B  Currant, dried                     0.060000   1.000     
1.000   dichlo

  Full comment: dichlobenil

04011380 4A   Dandelion, leaves                  0.188000   1.000     
1.000   

01031390 1CD  Dasheen, corm                      0.010000   1.000     
1.000   

02001400 2    Dasheen, leaves                    0.163000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

13011420 13A  Dewberry                           0.010000   1.000     
1.000   dichlo

  Full comment: dichlobenil

08001480 8    Eggplant                           0.010000   1.000     
1.000   

13021490 13B  Elderberry                         0.060000   1.000     
1.000   dichlo

  Full comment: dichlobenil

04011500 4A   Endive                             0.188000   1.000     
1.000   

04021520 4B   Fennel, Florence                   0.041000   1.000     
1.000   

14001550 14   Filbert                            0.020000   1.000     
1.000   

14001560 14   Filbert, oil                       0.020000   1.000     
1.000   

03001640 3    Garlic                             0.014000   1.000     
1.000   PP#737

  Full comment: PP#737172

03001650 3    Garlic, dried                      0.014000   1.000     
1.000   PP#737

  Full comment: PP#737172

03001651 3    Garlic, dried-babyfood             0.014000   1.000     
1.000   PP#737

  Full comment: PP#737172

01031660 1CD  Ginger                             0.010000   1.000     
1.000   

01031661 1CD  Ginger-babyfood                    0.010000   1.000     
1.000   

01031670 1CD  Ginger, dried                      0.010000   1.000     
1.000   

01011680 1AB  Ginseng, dried                     0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

13021740 13B  Gooseberry                         0.060000   1.000     
1.000   dichlo

  Full comment: dichlobenil

95001750 O    Grape                              0.100000   1.000     
1.000   

95001760 O    Grape, juice                       0.100000   1.200     
1.000   

95001761 O    Grape, juice-babyfood              0.100000   1.200     
1.000   

95001770 O    Grape, leaves                      0.100000   1.000     
1.000   

95001780 O    Grape, raisin                      0.100000   4.300     
1.000   

95001790 O    Grape, wine and sherry             0.100000   1.200     
1.000   

09011870 9A   Honeydew melon                     0.010000   1.000     
1.000   

01011900 1AB  Horseradish                        0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

13021910 13B  Huckleberry                        0.060000   1.000     
1.000   dichlo

  Full comment: dichlobenil

05011960 5A   Kohlrabi                           0.017000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

03001980 3    Leek                               0.014000   1.000     
1.000   PP#737

  Full comment: PP#737172

04012040 4A   Lettuce, head                      0.013200   1.000     
1.000   

04012050 4A   Lettuce, leaf                      0.038000   1.000     
1.000   

13012080 13A  Loganberry                         0.010000   1.000     
1.000   dichlo

  Full comment: dichlobenil

12002300 12   Nectarine                          0.040000   1.000     
1.000   

08002340 8    Okra                               0.010000   1.000     
1.000   

03002370 3    Onion, dry bulb                    0.010000   1.000     
1.000   PP#737

  Full comment: PP#737172

03002371 3    Onion, dry bulb-babyfood           0.010000   1.000     
1.000   PP#737

  Full comment: PP#737172

03002380 3    Onion, dry bulb, dried             0.010000   9.000     
1.000   PP#737

  Full comment: PP#737172

03002381 3    Onion, dry bulb, dried-babyfood    0.010000   9.000     
1.000   PP#737

  Full comment: PP#737172

03002390 3    Onion, green                       0.014000   1.000     
1.000   PP#737

  Full comment: PP#737172

04012480 4A   Parsley, leaves                    0.188000   1.000     
1.000   

01012500 1AB  Parsley, turnip rooted             0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

01012510 1AB  Parsnip                            0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

01012511 1AB  Parsnip-babyfood                   0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

12002600 12   Peach                              0.040000   1.000     
0.010   

12002601 12   Peach-babyfood                     0.040000   1.000     
0.010   

12002610 12   Peach, dried                       0.040000   7.000     
0.010   

12002611 12   Peach, dried-babyfood              0.040000   7.000     
0.010   

12002620 12   Peach, juice                       0.040000   1.500     
0.010   

12002621 12   Peach, juice-babyfood              0.040000   1.500     
0.010   

11002660 11   Pear                               0.271000   1.000     
0.010   

11002661 11   Pear-babyfood                      0.271000   1.000     
0.010   

11002670 11   Pear, dried                        0.271000   6.250     
0.010   

11002680 11   Pear, juice                        0.271000   1.000     
0.010   

11002681 11   Pear, juice-babyfood               0.271000   1.000     
0.010   

08002700 8    Pepper, bell                       0.010000   1.000     
1.000   

08002701 8    Pepper, bell-babyfood              0.010000   1.000     
1.000   

08002710 8    Pepper, bell, dried                0.010000   1.000     
1.000   

08002711 8    Pepper, bell, dried-babyfood       0.010000   1.000     
1.000   

08002720 8    Pepper, nonbell                    0.010000   1.000     
1.000   

08002721 8    Pepper, nonbell-babyfood           0.010000   1.000     
1.000   

08002730 8    Pepper, nonbell, dried             0.010000   1.000     
1.000   

12002850 12   Plum                               0.460000   1.000     
1.000   

12002851 12   Plum-babyfood                      0.460000   1.000     
1.000   

12002860 12   Plum, prune, fresh                 0.460000   1.000     
1.000   

12002861 12   Plum, prune, fresh-babyfood        0.460000   1.000     
1.000   

12002870 12   Plum, prune, dried                 0.460000   5.000     
1.000   

12002871 12   Plum, prune, dried-babyfood        0.460000   5.000     
1.000   

12002880 12   Plum, prune, juice                 0.460000   1.400     
1.000   

12002881 12   Plum, prune, juice-babyfood        0.460000   1.400     
1.000   

09023080 9B   Pumpkin                            0.010000   1.000     
1.000   

09023090 9B   Pumpkin, seed                      0.010000   1.000     
1.000   

04013130 4A   Radicchio                          0.013200   1.000     
1.000   

01013140 1AB  Radish, roots                      0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

02003150 2    Radish, tops                       0.163000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

01013160 1AB  Radish, Oriental, roots            0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

02003170 2    Radish, Oriental, tops             0.163000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

13013200 13A  Raspberry                          0.010000   1.000     
0.050   

13013201 13A  Raspberry-babyfood                 0.010000   1.000     
0.050   

13013210 13A  Raspberry, juice                   0.010000   1.000     
0.050   

13013211 13A  Raspberry, juice-babyfood          0.010000   1.000     
0.050   

04023220 4B   Rhubarb                            0.041000   1.000     
1.000   

01013270 1AB  Rutabaga                           0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

01013310 1AB  Salsify, roots                     0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

02003320 2    Salsify, tops                      0.163000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

03003380 3    Shallot                            0.014000   1.000     
1.000   PP#737

  Full comment: PP#737172

04013550 4A   Spinach                            0.188000   1.000     
1.000   

04013551 4A   Spinach-babyfood                   0.188000   1.000     
1.000   

09023560 9B   Squash, summer                     0.010000   1.000     
1.000   

09023561 9B   Squash, summer-babyfood            0.010000   1.000     
1.000   

09023570 9B   Squash, winter                     0.010000   1.000     
1.000   

09023571 9B   Squash, winter-babyfood            0.010000   1.000     
1.000   

01033660 1CD  Sweet potato                       0.010000   1.000     
1.000   

01033661 1CD  Sweet potato-babyfood              0.010000   1.000     
1.000   

04023670 4B   Swiss chard                        0.041000   1.000     
1.000   

01033710 1CD  Tanier, corm                       0.010000   1.000     
1.000   

08003740 8    Tomatillo                          0.010000   1.000     
1.000   

08003750 8    Tomato                             0.010000   1.000     
1.000   

08003751 8    Tomato-babyfood                    0.010000   1.000     
1.000   

08003760 8    Tomato, paste                      0.010000   5.400     
1.000   

08003761 8    Tomato, paste-babyfood             0.010000   5.400     
1.000   

08003770 8    Tomato, puree                      0.010000   3.300     
1.000   

08003771 8    Tomato, puree-babyfood             0.010000   3.300     
1.000   

08003780 8    Tomato, dried                      0.010000  14.300     
1.000   

08003781 8    Tomato, dried-babyfood             0.010000  14.300     
1.000   

08003790 8    Tomato, juice                      0.010000   1.500     
1.000   

01033870 1CD  Turmeric                           0.010000   1.000     
1.000   

01013880 1AB  Turnip, roots                      0.010000   1.000     
1.000   PP#7E7

  Full comment: PP#7E7172

86010000 O    Water, direct, all sources         0.056200   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.056200   1.000     
1.000   

09013990 9A   Watermelon                         0.010000   1.000     
1.000   

09014000 9A   Watermelon, juice                  0.010000   1.000     
1.000   

01034060 1CD  Yam, true                          0.010000   1.000     
1.000   

01034070 1CD  Yam bean                           0.010000   1.000     
1.000   

Attachment 5:  Chronic Food Plus Water Results File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for 2,6-DICHLOROBENZAMIDE (BAM)      (1994-98
data)

Residue file name: C:\DEEMFCID\BAM\BAM_domestic_chronicPP7E7271.R98

                                                     Adjustment factor
#2 used.

Analysis Date 03-18-2008/11:51:31     Residue file dated:
03-18-2008/11:51:13/8

Reference dose (RfD, Chronic) = .0045 mg/kg bw/day

COMMENT 1: New uses from PP#7E7172 + dichlobenil berries

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.001317               
29.3%

U.S. Population (spring season)             0.001305               
29.0%

U.S. Population (summer season)             0.001418               
31.5%

U.S. Population (autumn season)             0.001268               
28.2%

U.S. Population (winter season)             0.001275               
28.3%

Northeast region                            0.001236               
27.5%

Midwest region                              0.001322               
29.4%

Southern region                             0.001244               
27.6%

Western region                              0.001501               
33.4%

Hispanics                                   0.001459               
32.4%

Non-hispanic whites                         0.001295               
28.8%

Non-hispanic blacks                         0.001237               
27.5%

Non-hisp/non-white/non-black                0.001578               
35.1%

All infants (< 1 year)                      0.004170               
92.7%

Nursing infants                             0.001591               
35.4%

Non-nursing infants                         0.005149              
114.4%

Children 1-6  yrs                           0.002037               
45.3%

Children 7-12 yrs                           0.001225               
27.2%

Females 13-19 (not preg or nursing)         0.000912               
20.3%

Females 20+ (not preg or nursing)           0.001293               
28.7%

Females 13-50 yrs                           0.001244               
27.7%

Females 13+ (preg/not nursing)              0.001246               
27.7%

Females 13+ (nursing)                       0.001742               
38.7%

Males 13-19 yrs                             0.000941               
20.9%

Males 20+ yrs                               0.001155               
25.7%

Seniors 55+                                 0.001292               
28.7%

Children 1-2 yrs                            0.002284               
50.7%

Children 3-5 yrs                            0.001985               
44.1%

Children 6-12 yrs                           0.001297               
28.8%

Youth 13-19 yrs                             0.000930               
20.7%

Adults 20-49 yrs                            0.001196               
26.6%

Adults 50+ yrs                              0.001288               
28.6%

Females 13-49 yrs                           0.001196               
26.6%

------------------------------------------------------------------------
-------

Attachment 6:  Screening Level Estimates of Agricultural Uses of
Dichlobenil



-

"

#

$

3

C

3

L

a

b

Š

¤

Ý

萎ｌ萏ୀ萑褐葝ｌ葞ୀ葠褐摧⺬%฀C

D

K

L

V

Y

[

_

a

j

k

l

‰

Š

£

¤

 

 

(

.

f

g

n

t

›

œ

¨

¯

°

±

³

¹

(

)

J

o

s

t

œ

º

Í

Î

¹

º

»

Í

Î

Ù

ß

à

ç

è

ò

@

@

@

  h

  h

kdE

kd•

kd

$

kd

摧fHࠀ

kd

h

#

ó

h

h

@

@

@

愀Ĥ摧ಊTԀ

&

&

h

&

&

@

&

&

&

&

&

&

&

&

&

&

&

&

&

&

&

@

h

h

h

h

&

@

@

@

&

@

 h

  h

  h

h

gd

 h

  h

h

gd

@

@

@

 h

 h

# h

h

h

@

gd

@

@

gd

 

e

µ

E

•

å

@

@

Cherries	2,000	<1	<2.5

Cranberries	30,000	45	--

Grapes	3,000	<1	<2.5

Peaches	1,000	<1	<2.5

Pears	<500	<1	<2.5

Raspberries	1,000	  5	  5

Strawberries*	<500	<1	<2.5

*No tolerance is established on strawberries.

2,6-Dichlorobenzamide (BAM)          Dietary Exposure and Risk
Assessment               DP Number: 349722	

& Fluopicolide

PC Codes: 027402 and 027412

________________________________________________________________________
______________

                                                                        
                                                                        
               

 PAGE   8 

Page   PAGE  1  of   NUMPAGES  29