Document ID: EPA-HQ-OPP-2020-0263-0031
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2020-08-24T04:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                       SCIENTIFIC ADVISORY PANEL (SAP) 
              August 25, 2020, Public Virtual Preparatory Meeting
           September 15-18, 2020, Public Virtual Peer Review Meeting
 Food Quality Protection Act (FQPA) Science Review Board Biographical Sketches
                      Docket Number: EPA-HQ-OPP-2020-0263
                                       
Veronica J. Berrocal, PhD

 Affiliation: Associate Professor, Department of Statistics, University of California, Irvine, California.

 Expertise: Statistical methods for environmental exposure assessment (e.g., characterize environmental exposure) and effect of environmental exposure on health.

 Education: PhD, Statistics, University of Washington; MSc, Statistics, Michigan State University; Diplôme d'études approfondies (DEA) en Mathematiques, Université Joseph Fourier, Grenoble (now part of Université Grenoble Alpes), France; Laurea, Mathematics, Sapienza Università di Roma, Italy.

 Experience Summary: Dr. Veronica Berrocal is Associate Professor of Statistics at the University of California (UC), Irvine, California. She joined the Department of Statistics at UC, Irvine, in Fall 2019, after having been on the faculty at the University of Michigan in the Department of Biostatistics (first as Assistant Professor, then as Associate Professor; 2010-2019). Dr. Berrocal's research focuses on the development of statistical methods to characterize individuals' exposure to environmental risk factors (e.g., air pollution, weather, climate, built environment, etc.) and in estimating the effect of environmental exposure on health. Because of her research accomplishment in spatial and environmental statistics, Dr. Berrocal received the Early Investigator award from the Section on Statistics and the Environment of the American Statistical Association in 2015. Dr. Berrocal served and is currently serving as Associate Editor for: (i), the Journal of the American Statistical Association (2016-2018), the flagship journal for the American Statistical Association; (ii) the Journal of Agricultural, Biological and Environmental Statistics (2011-2018); and (iii) Bayesian Analysis (2018-present). She is currently also a statistical reviewer for the Journal of the American Medical Association (JAMA) Network Open (2018-present) and Lancet Psychiatry (2019-present).

 Panel Experience: Dr. Berrocal has served as ad-hoc member on the US Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) Scientific Advisory Panel four times (December 2014; May 2015; November 2017; November 2019). She has served as external peer reviewer for the US EPA on the "Environmental Relative Moldiness Index (ERMI)" (October 2016), and on "Significant Impact Levels (SILs) for ozone and fine particle pollution" (September 2016). Besides these experiences, Dr. Berrocal has served as a member on panels reviewing grant applications to National Institutes of Health (NIH) (ad-hoc member of the Biostatistical Methods and Research Design (BMRD) study section; June 2017); to National Institute of Environmental Health Sciences (NIEHS) for superfund centers (October 2016); the Health Effects Institute (2018); National Science Foundation (NSF) (May 2019) and National Aeronautics and Space Administration (NASA) (July 2019).

Harvey J. Clewell, PhD, DABT, FATS

 Affiliation: Principal Consultant, Ramboll US Corporation, Raleigh, North Carolina.
 Expertise: Incorporation of in vitro data, in silico modeling, and mode-of-action evaluation into chemical risk and safety assessment.
 Education: PhD, Toxicology, University of Utrecht, the Netherlands; MA, Chemistry, Washington University.
 Experience Summary: Dr. Harvey Clewell has gained an international reputation for his work on the incorporation of mechanistic data and mode of action information into chemical risk assessments, having played a role in the first uses of physiologically based pharmacokinetic (PBPK) modeling in cancer and non-cancer assessments by EPA, Agency for Toxic Substances and Disease Registry (ATSDR), Occupational Safety and Health Administration (OSHA), and Food and Drug Administration (FDA).
 Panel Experience: Dr. Clewell has previously served on external peer review panels for a number of EPA guidelines, including those for cancer risk assessment, risk characterization, benchmark dose modeling, and dermal absorption, and has participated in a number of chemical-specific reviews conducted by the EPA Science Advisory Board (SAB) and the FIFRA Scientific Advisory Panel (SAP). He also served as a member of the European Center for the Validation of Alternative Methods (ECVAM) Scientific Advisory Panel from 2012-2016. He is currently a member of the EPA Science Advisory Board (SAB) Chemical Assessment Advisory Committee.

                               Holly Davies, PhD
 Affiliation: Washington State Department of Health, Tumwater, Washington.

Expertise: Sustainability, human health and ecological risk assessments; scientific studies supporting state chemical policy.

Education: PhD, Genetics, University of Washington; BS, Biology, Cornell University.

Experience Summary: Dr. Holly Davies is a senior toxicologist at the Washington State Department of Health. She is an experienced professional in chemical policy, scientific research, and teaching. Her work has focused on evaluating uses of toxic chemicals, including chemicals of emerging concern and persistent, bioaccumulative, and toxic chemicals (PBT), and identifying actions needed to protect human health and the environment. Dr. Davies is a member of the Association for the Advancement of Alternatives Assessment and actively participates in the Children's Environmental Health Working Group within the Washington Chapter of the Collaborative on Health and the Environment. Her postdoctoral research (2000-2004) is on mammalian reproduction and development, transcription factors, and genomics.

Panel Experience: Dr. Davies has served on the Peer Review of the Draft Risk Assessment for Toxic Substances Control Act (TSCA) Work Plan Chemical 1-Bromopropane (CASRN-106-94-5) [May 24-25, 2016] advisory panel. and on the Chemical Safety Advisory Committee (CSAC) Orientation Session on Toxic Substances Control Act (TSCA) [May 11, 2016] advisory committee. Dr. Davies is currently a member of the TSCA Science Advisory Committee on Chemicals.
 

                     Marion F. Ehrich, RPh, PhD, DABT, ATS

 Affiliation: Professor, Pharmacology/Toxicology, Virginia Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia.

 Expertise: General and veterinary pharmacology, general toxicology, neurotoxicology, pesticide toxicology, and veterinary diagnostic toxicology.

 Education: PhD, Pharmacology/Toxicology, University of Connecticut, Storrs; MS Pharmacology/Toxicology, The University of Chicago; BS, Pharmacy, South Dakota State University. 

 Experience Summary: Dr. Marion Ehrich is a professor at Virginia-Maryland College of Veterinary Medicine (VMCVM) in Blacksburg, Virginia. In addition to teaching pharmacology and toxicology to veterinary, medical and graduate students, her professional responsibilities include serving as relief pharmacist in the Veterinary Medical Teaching Hospital Pharmacy as well as consultant in the Veterinary Toxicology Diagnostic Laboratory. Dr. Ehrich has been teaching at VMCVM since 1980, the year in which she became a member of the Society of Toxicology and a Diplomate of the American Board of Toxicology (DABT). Pharmacology teaching at the new medical school encompassed 2010-2017. She was elected a fellow of the Academy of Toxicological Sciences (ATS) in 1999. The Society of Toxicology provided Marion Ehrich with its Merit Award in 2010. She has served on numerous committees for that organization and was its president in 2003-2004.

 Panel Experience: US EPA FIFRA Scientific Advisory Panel, 2012-2019 (member of the permanent panel 2012-2018; invited ad hoc panel member 2019, 2010, 1996).
 National Institutes of Health (NIH), Special Study Sections, 2020 (1), 2019 (1), 2018 (3),
 2017, 2016, 2013 (2), 2009, 2008, 2004, 2002, 2000 (2), 1999, 1997, 1996 (2), 1995
 (2), 1986. Member of the National Academy of Sciences (NAS), Engineering and Medicine Review panel 2020. Chair of Committee for review of risk assessment processes for pesticides done by the California Department of Pesticide Regulations (DPR), 2014-2015. Member on Committee on Toxicology, 2005-2011. Other NAS/National Research Council (NRC) reviews (Gulf War, 2001-2002; Low Dose Chemical Mixtures, 2003-2004; Great Lakes Pollutants, 2008). Integrated Risk Information System (IRIS), US EPA, Review of science topics for hexahydro-1,3,5- trinitro-1,3,5-triazine, RDX), May 2016. United States Pharmacopia (USP) Expert Committee on Toxicology, 2010-2015. Veteran's Administration (VA) research grants, Chair, Study Section, 2012. Scientific Advisory Committee on Alternative Toxicological Methods (SACATM), NIH, NIEHS, 2006-2010.

 Penelope A. Fenner-Crisp, PhD Affiliation: Independent Consultant, North Garden, Virginia.
 Expertise: Toxicology and risk assessment; execution and/or management oversight of the development of human health and ecological risk assessments for environmental substances and for the risk assessment guidelines that support the development of these chemical-specific assessments.

 Education: Postdoctoral Fellowship, Georgetown University School of Medicine; PhD and MA, Pharmacology, University of Texas Medical Branch; BS, Zoology, University of Wisconsin-Milwaukee.

 Experience Summary: Dr. Penelope Fenner-Crisp has been an independent consultant since retiring from the International Life Sciences Institute as Executive Director of the Risk Science Institute (2000-2004). Prior to that, Dr. Fenner-Crisp served in a variety of capacities at US EPA, beginning her career in the Office of Drinking Water (ODW) as a Senior Toxicologist. Her responsibilities included managing the Health Advisory program, in which non-regulatory guidance was developed for contaminants in drinking water (1978-1987). From 1987-1989, she served as the Director of the Health and Environmental Review Division (now the Risk Assessment Division) in the Office of Pollution Prevention and Toxics (OPPT). For the balance of her career (1989-2000), she served as the Director of the Health Effects Division in the Office of Pesticide Programs (OPP), then its Deputy Office Director and Senior Science Advisor, as well as the official responsible for creating the Office of Science Coordination and Policy in the Office of Chemical Safety and Pollution Prevention.
 During these years, she was responsible for management oversight of the FIFRA Scientific Advisory Panel. Dr. Fenner-Crisp has served as a member of the boards of the Toxicology Forum (1991-2000), the Midwest Center for Environmental Science and Public Policy (2001-2006), GreenBlue (2006-2020) and the EPA Alumni Association (2017-present).

 Panel Experience: Some of Dr. Fenner-Crisp's post-EPA peer review experiences include the NAS expert group which published "Review of the Worker and Public Health Activities Program Administered by the Department of Energy and the Department of Health and Human Services" (2005-2006), the Food Advisory Committee of FDA's Center for Food Safety and Applied Nutrition (2008-2011), EPA's Science Advisory Board's Drinking Water Committee (2003-2009) and Committee on Science Integration in Decision-making (2009-2013). As an ad hoc member of the FIFRA Scientific Advisory Panel, Dr. Fenner-Crisp reviewed: 1) the status of the in utero through lactational assay in the EDSP (2007); 2) the Agency's activities related to the assessment of pyrethroid pesticides (2009 and 2010); and assessment activities related to atrazine (2010 and 2011) . In addition, she has participated in the review of: 1) the draft EPA Integrated Risk Information System (IRIS) document "Toxicological Review of Trichloroacetic Acid", 2) a Health Canada Regional Branch's "Evaluation of the Priority Substance List Assessment Report for Acrylonitrile," 3) the draft EPA Risk Assessment Forum "Framework for Human Health Risk Assessment to Inform Decision-making," 4) EPA OPPT's 2013 draft Trichloroethylene risk assessment (Chair), and 5) EPA's Physiologically-based Pharmacokinetic (PBPK) Model for Deltamethrin and Permethrin and PBPK-Pharmacodynamic (PBPK-PD) Model for Carbaryl (2018).

                     Helena T. Hogberg, PhD

 Affiliation: Deputy Director, Center for Alternatives to Animal Testing (CAAT), Environmental Health & Engineering, at Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

 Expertise: Research in developmental neurotoxicity and neurological disorders using in vitro approaches.

 Education: PhD, Toxicology and Physiology, Stockholm University, Sweden; MS, Molecular Biology, Stockholm University, Sweden; BS, Biology, Stockholm University, Sweden.

 Experience Summary: Dr. Helena Hogberg is faculty at Johns Hopkins Bloomberg School of Public Health (2010-present) teaching and researching neurotoxicology. Her PhD thesis aimed to develop in vitro approaches to evaluate chemical induced developmental neurotoxicity (DNT). The experimental work was performed at the European Centre for the Validation of Alternative Methods (ECVAM), Joint Research Centre, European Commission, Ispra, Italy (2005-2009). Dr. Hogberg is the Specialty Chief Editor for Neurotoxicology, Frontiers in Toxicology; Associate Editor for Predictive Toxicology, Frontiers in Pharmacology; and Member of Editorial Board of Elsevier Journal NeuroToxicology. Dr. Hogberg is currently the Secretary/Treasurer for the In Vitro and Alternative Methods Specialty Section of the Society of Toxicology (2020- present) and the councilor of the International Neurotoxicology Association (2017- present). She has been on the scientific steering committee for three of the five International Conferences on Alternatives for DNT (2010-present, Chair 2012-2014).
 She is currently appointed to the expert group on DNT of the International Council on Animal Protection in OECD Programs (2018-present) and member of the International Stakeholder Network for creating a (Developmental) Neurotoxicity Testing Roadmap (2013-present). Her primary research interests are NAMs for DNT using 3D models, Induced Pluripotent Stem Cells (iPSCs) and omics approaches.

 Panel Experience: Dr. Hogberg is directing the grants program of CAAT, Alan and Helene Goldberg In Vitro Toxicology Grants peer reviewed by CAATs board (2012- present). Dr. Hogberg is peer reviewer of grants for the Netherland Organisation for Scientific Research and Alternatives Research & Development Foundation (2015- present). She is on the Scientific Advisory Board for the European Commission funded Horizon 2020 grant - Novel Testing Strategies for Endocrine Disruptors in the Context of Developmental NeuroToxicity (2019-present) and of AxoSim (2019-present).

                     David A. Jett, PhD

 Affiliation: Program Director, NIH, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.

 Expertise: Neurotoxicology, pesticides, and translational toxicology.

 Education: PhD, Neuropharmacology and Toxicology, University of Maryland School of Medicine; MS, Zoology and Toxicology, University of Maryland at College Park; BA, Biology, Hampton Institute (now Hampton University).

 Experience Summary: Dr. David Jett is Director of the NIH Countermeasures Against Chemical Threats (CounterACT) Program, a program supported by a specific Congressional appropriation to the NIH for the development of new drugs and diagnostic tools for treating victims of chemical exposures during an emergency. He also serves as Program Director and Scientific Team Leader within the Division of Translational Research at the National Institute of Neurological Disorders and Stroke (NINDS). After receiving a PhD in Neuropharmacology and Toxicology at the University of Maryland School of Medicine, Dr. Jett conducted post-doctoral research and subsequently joined the faculty at Johns Hopkins University's Bloomberg School of Public Health where he conducted research as a university professor for several years. Dr. Jett has authored many scientific articles and book chapters in the area of neurotoxicology and has chaired sessions and given keynote addresses at many national and international scientific meetings. He holds the position of Professor Adjunct of Chronic Disease and Epidemiology within the Yale School of Public Health. Dr. Jett has served on White House and intergovernmental committees that set the nation's research priorities. Dr. Jett's other major interest at NIH is training and diversity.

 Panel Experience: EPA FIFRA Scientific Advisory Panel (member of Permanent panel), two terms (2014-2018).

                             Mark S. Johnson, PhD

Affiliation: Director of Toxicology, US Army Public Health Center at Aberdeen Proving Ground, Maryland.

Expertise: Toxicology, risk assessment, and ecology.

Education: PhD, Veterinary Science, Virginia-Maryland College of Veterinary Medicine; MSc, University of Delaware; BS, Biology, Towson State University.

Experience Summary: Dr. Johnson currently serves as the Director of Toxicology, US Army Public Health Center at Aberdeen Proving Ground, Maryland where he is responsible for the operational and technical arm of the Army Surgeon General and the Assistant Secretary of the Army for toxicological matters. He has worked extensively in the evaluation of the toxicity of military unique compounds and development and evaluation of a phased approach to the gathering of toxicity data for new compounds under development. Dr. Johnson has been a member of the Society of Environmental Toxicology and Chemistry (SETAC) since 1997 and is a Steering Group Member of several World Interest Groups (e.g., Wildlife Toxicology World Interest Group, Ecological Risk Assessment World Interest Group, and Science Committee for SETAC North America). Dr. Johnson is the chair of the Tri-Service Toxicology Consortium and has over 100 published peer-reviewed publications, technical reports, and book chapters on toxicology and risk assessment.

Panel Experience: Dr. Johnson has served on multiple North Atlantic Treaty Organization Science and Technology Organization (NATO STO panels) (e.g., Applied Vehicle Technology (AVT) 322 Combustion Products, Exposure and Related Risks, AVG-276-RLS-042 on Environmental Management of Munition and Greener Approaches to Design) and The Technical Cooperation Program (TTCP) Panels (WPN/Technical Panel 4, Energetic Materials and Propulsion Technology, Environmental Aspects of Energetic Materials, U.S. Area of Interest Annual Reports; TTCP Technical Report CP 4-42, Assessing the Potential Environmental and Human Health Consequences of Energetic materials: A Phased Approach, TR-WPN-TP04-15-2014). He is a Steering Group Member of the Wildlife Toxicology World Interest Group, Chair of Ecological Risk Assessment World Interest Group, and a member of the Science Committee for SETAC North America. Dr. Johnson was the past chair of the Terrestrial Toxicity Subcommittee of the Biological Fate and Effects Committee of the American Society for Testing and Materials (ASTM), and the past president of the American Board of Toxicology (ABT) and current chair of the Tri-Service Toxicology Consortium. He also serves as a government liaison on the National Research Council (NRC)/National Academy of Sciences (NAS) Committee on Emerging Science for Environmental Decision Making. Dr. Johnson is currently a member of the TSCA Science Advisory Committee on Chemicals.

                     John C. Lipscomb PhD, DABT, FATS

 Affiliation: Senior Toxicologist at CTEH, LLC, North Little Rock, Arkansas and Adjunct Professor of Toxicology, University of Louisville, Louisville, Kentucky.

 Expertise: Dr. Lipscomb has received recognition for his research into the toxicology and risk assessment of single chemicals and chemical mixtures. He has experience in developing and applying US EPA-level guidance for the conduct of quantitative health risk assessments.

 Education: PhD, Interdisciplinary Toxicology, University of Arkansas for Medical Sciences; MS and BS, Biology, University of Central Arkansas.

 Experience Summary: Dr. John Lipscomb is a Senior Toxicologist at CTEH, LLC, and Adjunct Professor of Toxicology at the University of Louisville. He is certified in toxicology (DABT) by the American Board of Toxicology and is a Fellow of the Academy of Toxicological Sciences (FATS). He is/has been an associate Editor for Toxicology Reports, Toxicology Mechanisms and Methods and Toxicological Sciences; has led regional chapters and specialty groups for the Society of Toxicology and the Society for Risk Analysis, served on Council for the Society of Toxicology and as President of the American Board of Toxicology. His research interests include developing non-default, quantitative (protective) risk values for public health protection and weight of evidence based (predictive) risk values for application in emergency response. He has over 100 peer reviewed publications, government technical reports and book chapters on topics including developmental toxicology, in vitro to in vivo extrapolation, toxicokinetics, drinking water disinfection byproduct toxicity and risk, mixtures and cumulative risk assessment, quantitative risk assessment and health guidance (risk) values. Dr.
 Lipscomb retired in 2019 from a 21-year career in US EPA's Office of Research and Development, where he co-led the development of Agency guidance for Data-Derived Extrapolation Factors.

 Panel Experience: None to date.

                             Kenneth Portier, PhD

Affiliation: Consulting Biostatistician, Athens, Georgia (Retired, National Cancer Society). 

Expertise: Statistical applications in agriculture, natural resources, environmental sciences and environmental health. More recently providing administrative and statistical support on design and analysis of cross-sectional and longitudinal sample surveys, program evaluations, models of cancer mortality and incidence, text mining and Geographical Information System (GIS) in cancer program planning. Specific expertise in statistical aspects of environmental sampling, toxicology, program evaluation, and geographical information systems. 

Education: PhD, Biostatistics and MS, Statistics, University of North Carolina-Chapel Hill; BS, Mathematics, Nicholls State University.

Experience Summary: Dr. Ken Portier has served as Vice President (2015-2017), Managing Director (2010-2015), Director of Statistics (2006-2010), Statistics and Evaluation Center, Intramural Research Department, American Cancer Society (ACS), Atlanta, Georgia. Affiliate Professor of Biostatistics, School of Public Health, Emory University (2006-2017). Assistant Research Scientist (1979-1981), Assistant Professor (1981-1986), Associate Professor (1986-2006), Experiment Station Statistician (1979-2006), Institute of Food and Agricultural Sciences and College of Agriculture, University of Florida, Gainesville. Courtesy faculty (2001-present), Center for Environmental and Human Toxicology, College of Veterinary Medicine, University of Florida, Gainesville.

Dr. Portier's research interests include statistical issues in environmental and human health risk assessment, applied statistical methods, multivariate data analysis, data and text mining, GIS applications in environmental and public health, use of technology in the learning of statistics, survey methodology including data imputation.

Panel Experience: Dr. Portier has participated in over 60 US Environmental Protection Agency (US EPA) FIFRA Scientific Advisory Panel meetings (1999 to 2013) and five EPA Science Advisory Board Review Panels (2012 to 2015). In addition, Dr. Portier served on expert and advisory panels for the National Institutes of Health (NIH); National Institute of Environmental Health Sciences (NIEHS); National Toxicology Program (NTP), and the World Health Organization Food and Agriculture Organization (WHO/FAO). Other panels Dr. Portier has served on include: NIH/NIEHS; Breast Cancer & Environmental Research Coordinating Committee (2010-2012); World Health Organization, Expert Panel, Toxicological and Health Aspects of Bisphenol A (2010); American Statistical Association, Section on Risk (2010); NTP/NIEHS/NIH Board of Scientific Counselors (2007-2009, Chair (2009); NTP/NIEHS/NIH, Center for the Evaluation of Risks to Human Reproduction, Expert Panel (2003 and 2008); Biometric Society (ENAR & WNAR) representative to the Ag and Life Sciences Committee of the American Association for the Advancement of Science (AAAS) (2005-2007). Dr. Portier previously served as Chair for the Chemical Safety Advisory Committee (CSAC) reviewing the Draft Risk Assessment for Work Plan Chemical 1-Bromopropane (2016). Dr. Portier is currently the Chair of the TSCA Science Advisory Committee on Chemicals.

                             Daniel M. Quinn, PhD

Affiliation: Emeritus Professor, Adjunct Professor; Department of Chemistry, University of Iowa, Iowa City, Iowa.

Expertise: Chemistry, biochemistry, and medicinal chemistry.

Education: PhD, Bioorganic Chemistry, The University of Kansas; BS, Chemistry, Quincy College.

Experience Summary: Dr. Quinn is an Emeritus Professor of Chemistry and Adjunct Professor at the University of Iowa. He has 38 years of teaching in organic chemistry and biotechnology; and research on the mechanism and inhibition of lipases and enzymes of the cholinergic neurotransmission system. Among the cholinergic enzymes studied in the Quinn lab were acetylcholinesterase and butyrylcholinesterase.

Panel Experience: Dr. Quinn has served on the NIH Countermeasures Against Chemical Threats (CounterACT) study section since 2012 and has served as co-chair since 2014. 
He has also been a member of the following NIH study sections: Training and Workforce Development (ad hoc) (2015), Biomedical Research Training (permanent member) (2008-2014), Biochemistry and Biophysics of Membranes (2005), Macromolecular Structure and Function (ad hoc), Physical Biochemistry Study Section (ad hoc) (2004, 2002, and 1996-1999), and Neurological Sciences Subcommittee (1989). Dr. Quinn has also served on grant review and fellowship committees for the following organizations: National Science Foundation (2014), Alzheimer's Association (2003), NIH Chemistry and Biophysics Fellowship Panel (2003), and US Army Medical Research and Material Command (2001).

                     Pamela J. Spencer, PhD, DABT

 Affiliation: Vice President, Regulatory, Product Stewardship & Quality, ANGUS Chemical Company, Buffalo Grove, Illinois.

 Expertise: Expertise in general toxicology, human health risk assessments and predictive toxicology; Extensive experience in regulatory toxicity testing and research to define human health risks, with publications in the areas of neurotoxicology, genetic toxicology, carcinogenicity and green chemistry.

 Education: Honorary Doctor of Science, Central Michigan University; PhD, Toxicology, University of Michigan, School of Public Health; MS, Biology, Central Michigan University; BS, Biology, Saginaw Valley State University.

 Experience Summary: Dr. Pamela Spencer is the Vice President of Regulatory, Product Stewardship & Quality at ANGUS Chemical Company, in Chicago, Illinois (2016
 - present). Prior to this role, she worked for the Dow Chemical Company for 30 years, retiring as the Scientific Director of Dow's Toxicology Environmental Research & Consulting function which included leading capability development for Dow's Predictive Toxicology Center (1985-2016). Dr. Spencer was a member of the Board of Directors for Center for Alternative Test Methods, Johns Hopkins School of Public Health (2013- 2016); Board of Directors for International Life Sciences Institute, Health and Environmental Sciences Institute (2016-present), Board of Directors for the Center for Contemporary Science (2019-present) and served on the Executive Council for the Society of Toxicology In Vitro and Alternative Methods (2016-present) and Sustainable Chemicals through Contemporary Toxicology (2019-present) Specialty Sections. Her research interests have focused on the protection of human health as it relates to solvent neurotoxicity, rapid carcinogen screening models and more recently on evaluation and application of predictive toxicology screening approaches to inform early screening safety assessments in new product development/reformulation and substitution of chemicals of high concern.

 Panel Experience: Dr. Spencer was appointed to the National Institute of Environmental Health Sciences (NIEHS), Scientific Advisory Committee on Alternative Toxicological Methods (2015-2019). She served as Chair of the committee from 2017-2019.

 Lisa M. Sweeney, PhD, DABT, CHMM Affiliation: Risk Assessment Toxicologist, UES, Inc., Dayton, Ohio. Expertise: Risk assessment, toxicokinetics, and toxicology.
 Education: BSE, Chemical Engineering, Case Western Reserve University; PhD Chemical Engineering, Cornell University.

 Experience Summary: Dr. Lisa Sweeney has a broad range of experience in the application of toxicology, chemistry, and engineering to problems in the health and environmental sciences. She has over 25 years of experience in risk assessment, pharmacokinetics, and biochemical engineering from private sector, non-profit and government perspectives. She is an author of over 50 peer-reviewed publications, with 30 as first author. Her experience has focused on the development and refinement of physiologically based pharmacokinetic (PBPK) models and their application to risk assessment and experimental design. Other risk assessment experience includes preparing toxicological reviews and calculating human health risks from exposure to compounds found in manufacturing and maintenance environments in accordance with US EPA guidance. She has also served as the principal investigator/project manager for in vivo acute toxicity and toxicokinetic studies.

 Panel Experience: Dr. Sweeney has experience with US EPA FIFRA SAP meeting, FQPA Science Review Board Member, Evaluation of a Proposed Approach to Refine Inhalation Risk Assessment for Point of Contact Toxicity: A Case Study Using a New Approach Methodology (NAM) (2018); US EPA FIFRA SAP meeting, FQPA Science Review Board Member, Review of Scientific Issues Associated with Chlorpyrifos: Analysis of Biomonitoring Data (2016); ATSDR manuscript review: Concentration-time extrapolation in the development of protective action criteria for airborne Hazardous Chemicals (2016); US EPA PPRTV review: ethylene cyanohydrin, On behalf of Eastern Research Group, under contract to US EPA (2012); US EPA IRIS review: methanol noncancer toxicity reference values, On behalf of Eastern Research Group, under contract to the US EPA (2011); ITERate review: Manganese RfC, On behalf of Toxicology Excellence for Risk Assessment (2011); US EPA PPRTV review: methacrylonitrile, On behalf of Eastern Research Group, under contract to US EPA (2011); US EPA IRIS review: ethyl tert-butyl ether toxicity reference values, On behalf of Eastern Research Group, under contract to the US EPA (2010); TERA Peer Consultation: Draft frame work to evaluate adult-child differences in inhalation dosimetry of gases: application to selected systemically-acting volatile organic chemicals (2007).