Document ID: EPA-HQ-OPP-2014-0375-0004
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2015-09-09T04:00Z

HOPGUARD® II

For use in beehives to control Varroa mites (Varroa destructor) on honey
bees

ACTIVE INGREDIENTS:                                                     
       BY WEIGHT

                        Potassium Salts of Hop Beta
Acids…………………………16.0%

OTHER INGREDIENTS:
…………………………………………….…. 84.0%

                                                                        
                 TOTAL             100.0%

KEEP OUT OF REACH OF CHILDREN

DANGER

PRECAUTIONARY STATEMENTS

Hazards to Humans and Domestic Animals

Danger:  Corrosive. Causes irreversible eye damage. Do not get in eyes
or on clothing. Wear (specify appropriate protective eyewear such as
goggles, face shield, or safety glasses). 

Wash thoroughly with soap and water after handling and before eating,
drinking, chewing gum, using tobacco or using the toilet. Remove and
wash contaminated clothing before reuse. 

FIRST AID

.

IF IN EYES: 	Hold eyelids open and flush with a steady, gentle stream of
water for 15-20 minutes. Remove contact lenses, if present, after the
first 5 minutes, then continue rinsing eye. Call a poison control center
or doctor for advice

IF ON SKIN OR  	Take off contaminated clothing. 

CLOTHING:	Rinse skin immediately with plenty of water for 15-20 minutes.

Call a poison control center or doctor for further treatment advice.

IF SWALLOWED: 	Call a poison control center or doctor immediately for
treatment advice.  

Have person sip a glass of water if able to swallow.

Do not induce vomiting unless told to do so by poison control center or
doctor. 

Do not give anything by mouth to an unconscious person.

Have the product container or label with you when calling a poison
control center or doctor, or going for treatment.  You may also contact
1-800-858-7378 for emergency medical treatment

For general information on product use, etc., call the National
Pesticides Information Center at 1-800-858-7378. For emergencies, call
the poison control center 1-800-222-1222. 

Note to Physician: “Probable mucosal damage may contraindicate the use
of gastric lavage”. See label back panel for additional precautionary
statements.

EPA Registration Number 83623-E              EPA Establishment Number
61671-MN-001

NET CONTENTS

Each HopGuard® kit contains 24 cardboard strips. Each strip is folded
in half and contains 4.0 grams of potassium salts of hop beta acids, and
the kit contains 96 grams (3.4 ounces) of potassium salts of hop beta
acids.

Manufactured by: BetaTec Hop Products, Inc., A Division of John I. Haas,
Inc., 1600 River Road, Yakima, WA 98902

PERSONAL PROTECTION EQUIPMENT (PPE): Applicators and other handlers must
wear appropriate protective eyewear, such as face shield or goggles long
sleeved shirt and long pants, waterproof gloves and shoes plus socks.

DIRECTIONS FOR USE

Bee Package- Cut strips in half. Strips must be applied at the rate of
three-half strips per 2 or 3 lb. package of adult worker bees. Attach
three-half strips to the top of package so that the strips are hanging
within the package. Place bees in the package after the strips are
attached. The bees should remain in contact with the strips for at least
48 hours.

Colony-  Strips must be applied at the rate of one strip per five deep
combs covered with bees in each brood super or for example two strips
per ten frame brood super (chamber) when all combs are covered with
bees. Strips are to be placed only in the brood chamber (not in the
honey super). Folded strips must be opened and hung over one of the
center brood frames near the middle of the frame with one-half of the
strip on each side of the frame. If using a second strip, apply it to an
adjacent center frame about four inches away from the first strip.
Strips must be placed hanging between frames, and within the colony
cluster, and not laid on top of the frames. Do not lay the strips on top
of the frames. Leave strips in the colony for 30 days. Retreat as
necessary, up to 3 times per year.

  A maximum of three applications per year (6 strips  or approximately
24 grams of potassium salts of hop beta acids) per ten frame brood super
(chamber) is allowed. This limit includes all applications to the
package(if applicable) and to the colony. Application timing (usually
during spring, summer, and fall) should be based on levels of Varroa
mite observed in the colony.  Users must not take honey and wax from the
brood chambers, only from the honey supers. For optimal results, apply
HopGuard® II when little to no brood is present in the hive.

RESISTANCE MANAGEMENT

Varroa mite populations can become resistant to pesticides. Resistance
development is affected by both the frequency of application and
rate/dose of application. After an application, the more susceptible
pests die and the less susceptible ones

survive, mate with other survivors, and reproduce. Most of the ensuing
offspring inherit the parental resistance. Additional

applications continue to kill only the remaining, unsusceptible
individuals. Continued reliance on a single class of miticide or 

miticide with the same mode of action will select for resistant
individuals which will dominate the mite population in

subsequent generations. In order to prevent resistance development and
to maintain the usefulness of individual pesticides

the adoption of an appropriate resistance management strategy is vital.
The Mode of Action (MOA) for hop beta acids is

undefined at this time: however, it may cause death by asphyxiation by
penetration of the pest's thin exoskeleton. 

To delay resistance:

• When possible, rotate the use of miticides to reduce selection
pressure as compared to repeatedly using the same 

  product, mode of action or chemical class. If multiple applications
are required, use a different mode of action each

  time before returning to a previously-used one. 

• Base rniticide use on Integrated Pest Management (IPM). This
includes proper pest identification, monitoring for

  locality, specific economic threshold and economic injury levels,
record keeping, and utilizing all available control 

  practices (cultural. biological and chemical).

• Maximize efficacy by following all label instructions including
dosage and timing of application. 

• Continually monitor treated populations for development of miticide
resistance and report suspected resistance to

   local extension specialists. 

• Contact your local extension specialist for additional pesticide
resistance/management recommendations and/or

   !PM recommendations for your specific location. 

• For further information or to report suspected resistance contact
your local extension specialist.

• Remove strips if still in hive after 30 days.

					RESTRICTIONS

For in-hive use only.

Maximum rate = 2 strips per brood chamber per application (i.e. one
strip per five frames covered with bees).

Remove remaining strip(s) after 30 days. 

Do not use HopGuard® II more than 3 times per year.

STORAGE AND DISPOSAL

Unused strips should be stored in a tightly sealed, cool, dark area.
Unused, unregistered product must either be returned to the manufacturer
or distributor in unopened containers or disposed of in accordance with
the Resource Conservation Recovery Act.

USER SAFETY RECOMMENDATIONS:  Users must:

Wash hands before eating, drinking, chewing gum, using tobacco or using
the toilet.

Remove clothing immediately if pesticide gets inside.  Then wash
thoroughly and put on clean clothing.

Remove PPE immediately after handling this product.  Wash the outside of
gloves before removing.  As soon as possible, wash thoroughly and change
into clean clothing.