Document ID: EPA-HQ-OPP-2005-0150-0002
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2005-06-23T04:00Z

UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
MEMORANDUM
Date:
22­
JUN­
2005
Subject:
Revised
as
per
30­
day
Error
Only
Registrant
Comments.
Sethoxydim.
HED
Chemistry
Chapter
of
the
Reregistration
Eligibility
Decision
(
RED).
Summary
of
Analytical
Chemistry
and
Residue
Data.
Case
No.
2600
DP
Number:
D318169
PC
Code:
121001
Chemical
Class:
Cyclohexenone
From:
William
H.
Donovan,
Ph.
D.,
Chemist
Reregistration
Branch
3
Health
Effects
Division
(
7509C)

Through:
Danette
Drew,
Branch
Senior
Scientist
Reregistration
Branch
3
Health
Effects
Division
(
7509C)

To:
James
Parker,
Chemical
Review
Manager
Reregistration
Branch
1
Special
Review
and
Reregistration
Division
[
7508C]

This
document
was
originally
prepared
under
contract
by
Versar
Corporation.
The
document
has
been
reviewed
by
HED
and
revised
to
reflect
current
OPP
policies.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
2
of
101
Executive
Summary
Sethoxydim
is
a
selective,
systemic,
postemergence
herbicide
used
for
the
control
of
annual
and
perennial
grass
weeds
in
broadleaf
crops.
Sethoxydim
is
a
member
of
the
cyclohexenone
class
of
pesticides.
The
current
formulations
of
sethoxydim
are
comprised
of
emulsifiable
concentrates
(
ECs).
The
active
ingredient
(
ai)
sethoxydim
in
these
formulations
range
from
13
to
43%.
Sethoxydim
is
registered
for
application
to
a
number
of
crops;
application
rates
and
pre­
harvest
interval
(
PHI)
requirements
vary
depending
on
the
crop.

The
qualitative
nature
of
the
residue
in
plants
is
adequately
understood
based
on
soybean,
tomato
and
sugar
beet
metabolism
studies.
The
nature
of
the
residue
in
livestock
is
understood
based
on
acceptable
metabolism
studies
in
ruminants
(
goat)
and
poultry
(
hens).
The
residues
of
concern
in
plants
and
livestock
are
the
combined
residues
of
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
(
calculated
as
sethoxydim).
For
risk
assessment
purposes,
the
residues
in
water
are
parent
plus
degradates.
The
degradates
which
are
expected
to
be
found
in
water
are
the
sulfoxide
and
sulfone
derivatives
of
the
parent
(
MSO
and
MSO2)
along
with
M1S
(
loss
of
ethoxy
group
on
imino
nitrogen)
and
M2S
(
formation
of
oxazole
ring).

BASF
Wyandotte
Corporation's
(
BWC's)
Methods
No.
30,
30G,
30H
and
A9003
are
adequate
analytical
methods
for
data
collection
and/
or
enforcement
of
tolerances
for
residues
of
sethoxydim
and
its
metabolites
in
or
on
plant
and
animal
commodities.
In
these
methods,
residues
are
determined
by
gas­
liquid
chromatography
with
flame
photometric
detection
(
GLC/
FPD).
Method
30
is
included
as
Method
I
in
PAM
II.
Methods
30G,
30H
and
A9003
have
been
submitted
for
publication
in
PAM
II
as
lettered
methods.

Tolerances
have
been
established
under
40
CFR
§
180.412
for
the
combined
residues
of
sethoxydim
[
2­[
1­(
ethoxyimino)
butyl]­
5­[
2­(
ethylthio)
propyl]­
3­
hydroxy­
2­
cyclohexen­
1­
one]
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
(
calculated
as
sethoxydim)
in
or
on
numerous
agricultural
commodities.
Permanent
tolerances
are
established
(
40
CFR
§
180.412)
for
residues
of
the
herbicide
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
in
meat
and
fat
of
cattle,
goats,
hogs,
horses,
poultry,
and
sheep
at
0.2
ppm;
meat
byproducts
of
cattle,
goats,
hogs,
horses,
and
sheep
at
1.0
ppm
(
2.0
ppm
in
meat
byproducts
of
poultry);
eggs
at
2.0
ppm,
and
milk
at
0.5
ppm.
The
tolerance
expression
for
plant
and
livestock
commodities
includes
the
combined
residues
of
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
(
calculated
as
the
herbicide)
as
specified
in
40
CFR
§
180.412.

Crop
field
trial
and
processing
studies
have
been
submitted
by
the
registrant.
In
the
Phase
IV
review
for
sethoxydim,
HED
requested
magnitude
of
residue
studies
for
various
crops
to
fulfill
data
gaps
identified
during
review.
Subsequent
to
the
completion
of
the
Phase
IV
review,
the
validity
of
certain
field
studies
was
questioned
because
residue
samples
from
those
studies
had
been
analyzed
in
a
particular
contract
laboratory,
Craven
Labs.
As
a
result,
the
Agency
issued
a
DCI
to
replace
crop
field
trial
data
generated
by
Craven
Labs
for
alfalfa
hay,
artichoke,
succulent
beans,
dry
beans,
broccoli,
cabbage,
mustard
greens,
cotton,
flax,
peppers,
tomatoes,
grapes,
lentils,
peanuts,
succulent
peas,
dry
peas,
potatoes,
raspberry,
soybeans,
strawberry
and
sugar
beets.
Additionally,
the
DCI
requested
replacement
data
for
bean
and
grape
processing
studies.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
3
of
101
Only
data
not
generated
by
Craven
Labs
are
discussed
in
this
document.
In
general,
residue
data
support
the
existing
tolerances.

Regulatory
Recommendations
and
Residue
Chemistry
Deficiencies
Tolerances
have
been
established
under
40
CFR
§
180.412
for
the
combined
residues
of
sethoxydim
[
2­[
1­(
ethoxyimino)
butyl]­
5­[
2­(
ethylthio)
propyl]­
3­
hydroxy­
2­
cyclohexen­
1­
one]
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
(
calculated
as
sethoxydim)
in
or
on
numerous
plant
and
animal,
food
and
feed
commodities.
HED
supports
these
tolerances,
provided
that
the
following
deficiencies
and
data
gaps
are
resolved:

1)
Crop
field
trials
Safflower
­
Two
additional
residue
studies
from
Region
10
are
needed.

2)
Tolerance
Revocation
The
following
tolerances
should
be
revoked:

­
Flax,
straw
­
Flax,
meal
­
Peanut,
soapstock
­
Tomato,
dry
pomace
­
Tomato,
concentrated
products
­
Citrus,
molasses
3)
Tolerance
Increases
The
maximum
residues
detected
in
the
crop
field
samples
are
higher
than
the
tolerance
for
the
following
commodities:

­
Clover
hay
(
maximum
residue
of
50.7
ppm,
tolerance
of
50
ppm).
Increase
tolerance
level
to
55
ppm.
­
Cranberries
(
maximum
residue
of
2.2
ppm,
tolerance
of
2
ppm).
Increase
tolerance
level
to
2.5
ppm.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
4
of
101
S
H
3
C
CH
3
OH
CH
3
O
N
O
CH
3
DME
Background
The
PC
Code
and
nomenclature
of
sethoxydim
are
listed
below
in
Table
1,
the
chemical
names
and
structures
of
the
metabolites
are
listed
in
Table
2,
and
the
physicochemical
properties
of
sethoxydim
are
listed
in
Table
3.

TABLE
1.
Sethoxydim
Chemical
Structure
Common
name
Sethoxydim,
MS
Company
experimental
name
BAS
9052
H
IUPAC
name
(
±
)
­(
EZ)­
2­(
1­
ethoxyiminobutyl)­
5­[
2­(
ethylthio)
propyl]­
3­
hydroxycyclohex­
2­
enone
CAS
name
(
±
)
­
2­[
1­(
ethoxyimino)
butyl]­
5­[
2­(
ethylthio)
propyl]­
3­
hydroxy­
2­
cyclohexen­
1­
one
CAS
#
74051­
80­
2
TABLE
2.
Chemical
names
and
structures
of
metabolites
of
sethoxydim
Common
name
Chemical
Name
Structure
DME
3­[
2­(
ethylsulfonyl)
propyl]­
pentanedioic
acid
dimethyl
ester
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
TABLE
2.
Chemical
names
and
structures
of
metabolites
of
sethoxydim
Common
name
Chemical
Name
Structure
5
of
101
DME­
OH
MSO
M1S
DME­
OH
3­[
2­(
ethylsulfonyl)
propyl]­
3­
hydroxypentanedioic
acid
dimethyl
ester
MSO;
sethoxydim
sulfoxide
2­[
1­(
ethoxyimino)
butyl]­
5­[
2­
(
ethylsulfinyl)
propyl]­
3­
hydroxy­
2­
cyclohexen­
1­
one
M1S
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
TABLE
2.
Chemical
names
and
structures
of
metabolites
of
sethoxydim
Common
name
Chemical
Name
Structure
6
of
101
5­
OH­
MSO
MSO2
M1SO
5­
OH­
MSO
MSO2;
sethoxydim
sulfone
2­[
1­(
ethoxyimino)
butyl]­
5­[
2­
(
ethylsulfonyl)
propyl]­
3­
hydroxy­
2­
cyclohexen­
1­
one
M1SO
2­[
1­(
imino)
butyl]­
5­[
2­
(
ethylsulfinyl)
propyl]­
3­
hydroxy­
2­
cyclohexen­
1­
one
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
TABLE
2.
Chemical
names
and
structures
of
metabolites
of
sethoxydim
Common
name
Chemical
Name
Structure
7
of
101
M1SO2
M2SO
OH
MSO2
M1SO2
M2SO
6­[
2­(
ethylsulfinyl)
propyl]­
6,7­
dihydro­
2­
propyl­
4(
5H)­
benzoxazolone
5­
OH­
MSO2;
5­
hydroxy
sethoxydim
sulfone
2­[
1­(
ethoxyimino)
butyl]­
5­[
2­
(
ethylsulfonyl)
propyl]­
3,5­
dihydroxy­
2­
cyclohexen­
1­
one
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
TABLE
2.
Chemical
names
and
structures
of
metabolites
of
sethoxydim
Common
name
Chemical
Name
Structure
8
of
101
M2S
MGSO
MGSO2
M2S
MGSO
MGSO2
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
TABLE
2.
Chemical
names
and
structures
of
metabolites
of
sethoxydim
Common
name
Chemical
Name
Structure
9
of
101
M2SO2
OH­
M2SO2
M2SO2
6­[
2­(
ethylsulfonyl)
propyl]­
6,7­
dihydro­
2­
propyl­
4(
5H)­
benzoxazolone
5­
OH­
M2SO2
Table
3.
Physical
and
Chemical
Properties
of
Sethoxydim
Property
Description
Reference
(
MRID#)

Color
brown
41607203
Physical
state
viscous
liquid
41607203
Odor
garlic­
like
41607203
Boiling
Point
>
130

C
at
6
x
10­
1
mm
Hg
41607203
Density,
bulk
density,
or
specific
gravity
1.058
specific
gravity
at
20

C
41607203
Solubility
Water
at
25

C:
2.57
x
10
2
ppm
at
pH
5,
4.39
x
10
3
ppm
at
pH
7;
organic
solvents
(
methanol,
n­
octanol,
ethyl
acetate,
n­
hexane,
toluene,
xylene,
and
olive
oil)
at
20

C:
freely
soluble
(>
10
3
g/
100
mL).
41475201
41510601
Vapor
pressure
1.6
x
10
­
7
mm
Hg
at
25

C
00047647
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Table
3.
Physical
and
Chemical
Properties
of
Sethoxydim
Property
Description
Reference
(
MRID#)

10
of
101
Dissociation
constant
pKa
is
4.6
at
pH
4.5
and
25

C
00047650
Octanol/
water
partition
coefficient
Kow
is
3.26
x
10
3
at
pH
5;
45.1
at
pH
7;
0.93
at
pH
9
41475202
pH
3.95
at
20

C
41607203
Stability
stable
at
normal
temperatures
(
24

C)
and
in
the
presence
of
metals
(
zinc
or
iron
powder);
unstable
at
elevated
temperatures
(
54

C)
and
in
the
presence
of
sunlight.
41607203
860.1200
Directions
for
Use
Product
List
A
product
registration
query
of
the
Agency's
OPPIN
database
identified
5
active
sethoxydim
end­
use
products
(
EPs)
registered
for
use
on
food/
feed
sites.
All
five
end­
products
are
registered
to
BASF
Corporation
and
are
intended
for
use
on
a
variety
of
crops.
The
EPs
are
listed
in
Table
4
below.
Additionally,
the
query
identified
19
Special
Local
Needs
(
SLN)
registrations
and
73
Section
18
Emergency
Exemption
Registrations.
The
most
recent
Section
18
Emergency
Exemption
is
from
2003
(
03ND15).
The
remainder
Section
18
Emergency
Exemptions
are
from
1982
to
2002.

TABLE
4.
Sethoxydim
End­
Use
Products
(
EPs)
with
Food/
Feed
Uses.

EPA
Reg.
No.
Formulation1
Registrant
Product
Name2
7969­
58
EC
­
18.0%
ai
BASF
Corporation
Poast
®
Herbicide
ManifestJ
Herbicide
ConcludeJ
Herbicide
Poast
®
S
Herbicide
7669­
88
EC
­
13.0%
ai
BASF
Corporation
Poast
Plus
®
Herbicide
Vantage
®
Herbicide
Rezult
®
Herbicide
Torpedo
®
Herbicide
7669­
121
EC
­
16.2%
ai
BASF
Corporation
UltimaJ
160
Herbicide
7969­
129
EC
­
43.0%
ai
BASF
Corporation
Poast
®
3.5
Herbicide
Conclude
®
Ultra
G
Herbicide
(
43.3%
ai)
Poast
®
HC
Herbicide
7969­
176
EC­
25.5%
ai
BASF
Corporation
Poast
®
2.0
Herbicide
1.
EC=
Emulsifiable
concentrate
2.
The
product
name
in
bold
is
the
current
product
name
according
to
OPPIN.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
11
of
101
Use
Patterns
Table
5
presents
a
summary
of
the
use
directions
based
on
the
supported
uses
as
specified
in
the
Sethoxydim
Use
Closure
Memo
(
A.
Johnson,
9/
14/
2004).
For
the
purposes
of
reregistration,
the
registered
food/
feed
uses
of
sethoxydim
have
been
re­
evaluated
for
all
the
plant
and
animal
commodities
for
which
tolerances
exist.
A
tabular
summary
of
the
chemistry
science
assessments
is
presented
in
Table
6.
The
conclusions
listed
in
Table
6
regarding
the
reregistration
eligibility
of
sethoxydim
food/
feed
uses
are
based
on
the
use
patterns
registered
by
the
producer.
When
end­
use
product
data
call
ins
(
DCIs)
are
developed
(
e.
g.,
at
issuance
of
the
RED),
SRRD
should
ensure
that
all
end­
use
product
labels
(
e.
g.,
MAI
labels,
SLNs,
and
products
subject
to
the
generic
data
exemption)
are
consistent
with
the
basic
producer
labels.

Table
5.
Summary
of
Sethoxydim
Use
Directions
Crop
Minimum
Time
From
Application
to
Harvest
(
PHI)
(#
of
days)
Maximum
Rate
Per
Acre
Per
Application
(
lb
ai/
acre)
Maximum
Rate
Per
Acre
Per
Season
(
lb
ai/
acre)

Alfalfa,
birdsfoot
trefoil,
and
sanfoin
(
dried)
14
0.47
1.2
Alfalfa,
birdsfoot
trefoil,
and
sanfoin
(
undried)
7
0.47
1.2
Apricot
25
0.47
0.94
Artichoke,
Globe
7
0.47
0.94
Asparagus
1
0.47
0.94
Avacado
(
nonbearing)
365
0.47
1.4
Beans
;
Dry,
Succulent
30
15
0.47
0.75
Beet
(
Garden)
60
0.47
0.94
Blueberry
30
0.47
0.94
Brassica
(
Crop
Group
5)
30
0.28
0.56
Bulb
Vegetables
(
Crop
Group
3)
30
0.28
0.84
Caneberries
(
Crop
Subgroup
13A)
45
0.47
0.94
Canola/
Crambe/
Rapeseed
60
0.47
0.94
Carrot
30
0.47
0.94
Cherries
(
sweet
and
sour)
25
0.47
0.94
Christmas
tree
farms
n/
a
0.47
0.56
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Table
5.
Summary
of
Sethoxydim
Use
Directions
Crop
Minimum
Time
From
Application
to
Harvest
(
PHI)
(#
of
days)
Maximum
Rate
Per
Acre
Per
Application
(
lb
ai/
acre)
Maximum
Rate
Per
Acre
Per
Season
(
lb
ai/
acre)

12
of
101
Citrus
(
Crop
Group
10)
15
0.47
1.9
Clover
7
(
before
grazing,
feeding,
or
cutting
for
undried
forage)
0.47
1.2
Clover
hay
20
(
before
grazing,
feeding,
or
cutting
for
dry
hay)
0.47
1.2
Corn
(
Poast
®
protected
field
corn)
60
(
grain
or
fodder)
45
(
forage
and
silage)
0.28
0.56
Corn
(
Poast
®
protected
sweet
corn)
45
(
grain
or
fodder)
30
(
fresh
sweet
corn
or
forage
and
silage)
0.28
0.56
Cotton
40
0.47
1.4
Cranberry
60
0.47
0.94
Curcubits
(
Crop
Group
9)
14
0.28
0.56
Date
(
nonbearing)
365
0.47
1.4
Deciduous
trees,
Nonfood
Crop
Areas,
Fallow
Land
n/
a
0.47
n/
a
Fescue
(
tall)
n/
a
0.47
n/
a
Fig
(
nonbearing)
365
0.47
1.4
Flax
75
0.28
0.75
Fruiting
Vegetables
(
Crop
Group
8)
20
0.28
0.84
Grape
50
0.47
0.94
Head
and
Petiole
Type
Vegetables
(
Crop
Subgroup
4B)
30
0.28
0.56
Horseradish
60
0.47
0.94
Leafy
Vegetables
(
Crop
Group
4)
15
0.28
0.56
Lentil
50
0.47
0.75
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Table
5.
Summary
of
Sethoxydim
Use
Directions
Crop
Minimum
Time
From
Application
to
Harvest
(
PHI)
(#
of
days)
Maximum
Rate
Per
Acre
Per
Application
(
lb
ai/
acre)
Maximum
Rate
Per
Acre
Per
Season
(
lb
ai/
acre)

13
of
101
Lingonberry,
Salal,
Juneberry
45
0.47
0.94
Mint
20
0.47
0.94
Nectarine
25
0.47
0.94
Non­
bearing
food
crops
n/
a
0.47
0.56
Nursery
plantings
n/
a
0.47
0.56
Olives
(
nonbearing)
365
0.47
1.4
Orchard
floor
middles
n/
a
0.09
0.09
Ornamentals
n/
a
0.47
0.56
Peach
25
0.47
0.94
Peanut
40
0.28
0.47
Peas,
Dry
Succulent
30
15
0.47
0.47
0.75
Pistachio
15
0.47
1.9
Plum
(
nonbearing)
365
0.47
1.4
Pome
fruits
(
Crop
Group
11)
14
0.47
1.4
Pomegranate
(
nonbearing)
365
0.47
1.4
Potatoes,
Field
Sweet
(
East
US)
Sweet
(
West
US)
30
30
60
0.47
0.47
0.28
0.94
0.94
0.94
Prune
(
nonbearing)
365
0.47
1.4
Rights­
of­
way
n/
a
0.47
0.56
Roadsides
n/
a
0.47
0.56
Safflower
30
0.47
0.94
Set
Aside
Conservation
Land
n/
a
0.47
1.4
Soybean
75
0.47
0.94
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Table
5.
Summary
of
Sethoxydim
Use
Directions
Crop
Minimum
Time
From
Application
to
Harvest
(
PHI)
(#
of
days)
Maximum
Rate
Per
Acre
Per
Application
(
lb
ai/
acre)
Maximum
Rate
Per
Acre
Per
Season
(
lb
ai/
acre)

14
of
101
Strawberry
7
0.47
0.47
Sugar
beet
60
0.47
0.94
Sunflower
70
0.47
0.47
Tobacco
42
0.28
0.75
Tree
Nuts
(
Crop
Group
14)
15
0.47
1.9
Tuberous
and
Corm
Vegetables
(
Crop
Subgroup
1C)
30
0.47
0.94
Turf/
lawns
n/
a
0.47
0.56
Wildflowers
n/
a
0.47
0.56
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
15
of
101
TABLE
6.
Residue
Chemistry
Science
Assessment
for
Reregistration
of
Sethoxydim
(
121001).

GLN
Data
Requirements
Current
Tolerances
(
ppm)
[
§
180.412]
Additional
Data
Needed?
MRID
Nos.

860.1200:
Directions
for
Use
N/
A
=
Not
Applicable
No
N/
A
860.1300:
Nature
of
the
Residue
­
Plants
°
Soybeans
N/
A
No
92166094
1
°
Tomatoes
N/
A
No
00148007
2
°
Sugar
Beets
N/
A
No
43144501
3
43467001
4
860.1300:
Nature
of
the
Residue
­
Animals
°
Goat
N/
A
No
00153602
(
summary
in
92166046)
5
°
Hen
N/
A
No
00155129
(
summary
in
92166047)
6
860.1340:
Residue
Analytical
Method
°
Plant
Commodities
N/
A
No
Not
available
7
°
Animal
Commodities
N/
A
No
Not
available
7
860.1360:
Multiresidue
Method
N/
A
No
41980701
8
860.1380:
Storage
Stability
Data
°
Plant
Commodities
N/
A
No
43801401
9
00130578
10
°
Animal
Commodities
N/
A
No
43223401
11
860.1400:
Magnitude
of
the
Residue
­
Water,
Fish,
and
Irrigated
Crops
N/
A
N/
A
N/
A
860.1460:
Magnitude
of
the
Residue
­
Food
Handling
N/
A
N/
A
N/
A
860.1480:
Magnitude
of
the
Residue
­
Meat,
Milk,
Poultry,
Eggs
°
Cattle,
goat,
hog,
horse,
sheep,
&
poultry­
fat
and
meat
0.2
No
00153602
and
0042808
(
summary
in
92166049)
12
°
Cattle,
goat,
hog,
horse,
&
sheep
­
meat
byproducts
1
No
°
Poultry
­
meat
byproducts
2
No
°
Egg
2.0
No
°
Milk
0.5
No
860.1500:
Crop
Field
Trials
°
Alfalfa
forage
40
No
00155129
13
40515801
13
°
Alfalfa
hay
40
No
41970901
14
°
Almonds
2
No
41428501
15
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
TABLE
6.
Residue
Chemistry
Science
Assessment
for
Reregistration
of
Sethoxydim
(
121001).

GLN
Data
Requirements
Current
Tolerances
(
ppm)
[
§
180.412]
Additional
Data
Needed?
MRID
Nos.

16
of
101
°
Apricot
0.2
No
41236404
16
°
Artichoke,
globe
5
No
43973101
17
°
Asparagus
No
42487401
18
42487402
18
42834201
19
42834202
19
43051701
20
°
Bean,
dry,
seed
20
No
43801413
21
°
Bean,
forage
15
No
43801411
21
43801413
21
°
Bean,
hay
50
No
43801411
21
43801413
21
°
Bean,
succulent
15
No
43801411
21
°
Beet,
garden
1
No
None
22
°
Beet,
sugar,
roots
1
No
155129
23
and
40639101
24
(
summary
in
92166067),
40639102
24
°
Beet,
sugar,
tops
3
No
155129
23,
40639101
24,
40639102
24
°
Blueberry
4
No
40492604
(
summary
in
92166072)
25
°
Caneberry
subgroup
13A
5
No
4397270125
00157187
(
summary
in
92166066)
26
°
Canola/
rapeseed
35
No
42074201
27
°
Carrots
1
No
42195001
24,
28
°
Cherry,
sweet
0.2
No
41236401
29
°
Cherry,
tart
0.2
No
41236401
29
°
Citrus
0.5
No
40492601
40492602
40492603
°
Clover
forage
35
No
42353601
30
°
Clover
hay
50
No
42353601
30
°
Coriander
4
No
None
31
°
Corn,
field,
grain
0.5
No
43178701
32
43455701
32
°
Corn
fodder
2.5
No
43178701
32
43455701
32
°
Corn
forage
2
No
43178701
32
43455701
32
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
TABLE
6.
Residue
Chemistry
Science
Assessment
for
Reregistration
of
Sethoxydim
(
121001).

GLN
Data
Requirements
Current
Tolerances
(
ppm)
[
§
180.412]
Additional
Data
Needed?
MRID
Nos.

17
of
101
°
Corn,
sweet,
forage
3
No
45100501
33
°
Corn,
sweet,
kernel
plus
cob
with
husks
removed
0.4
No
45100501
33
°
Corn,
sweet,
stover
3.5
No
45100501
33
°
Cotton,
undelinted,
seed
5
No
43062205
34
°
Cranberry
2
No
41627001
35
°
Flax,
seed
5
No
43801409
21
°
Flax,
straw
2
No
43801409
21
°
Grape
1
No
43801410
21
°
Horseradish
4
No
None
36
°
Juneberry
5
No
None37
°
Lentil,
seed
30
No
None
21
°
Lingonberry
5
No
None
37
°
Nectarine
0.2
No
41236404
16
°
Peach
0.2
No
41236402
16
°
Peanut
25
No
43801408
21
9216606326
°
Pea,
dry,
seed
40
No
43801414
21
°
Pea,
field,
vines
(
forage)
20
No
43801414
21
43801415
21
°
Pea,
field,
hay
40
No
43801414
21
43801415
21
°
Pea,
succulent
10
No
43801415
21
°
Peppermint,
tops
(
stems
and
leaves)
30
No
42101701
38
°
Pistachio
0.2
No
None
39
°
Pome
Fruit
0.2
No
40576101
40576102
°
Rhubarb
0.3
No40
41072001
°
Salal
5
No
None
37
°
Safflower
15
Yes
41
44864501
°
Soybean
(
seed)
16
No
43801412
21
100535
43
°
Soybean,
hay
10
No
153602
21
43801412
21
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
TABLE
6.
Residue
Chemistry
Science
Assessment
for
Reregistration
of
Sethoxydim
(
121001).

GLN
Data
Requirements
Current
Tolerances
(
ppm)
[
§
180.412]
Additional
Data
Needed?
MRID
Nos.

18
of
101
°
Spearmint,
tops
(
stems
and
leaves)
30
No
42101701
38
°
Strawberry
10
No
41342801
°
Sunflower,
seed
7
No
MRID
00131857
(
Summary
in
MRID
92166068)
23;
Accession
Number
07342444
°
Tree
nut
0.2
No
41428502
15
41428503
15
41428501
15
°
Tuberous
and
corm
vegetable
crop
subgroup
4
No
43801407
21
°
Vegetable,
brassica,
leafy,
group
5
5
No
43801403
45
43801404
45
43801405
45
°
Vegetable,
bulb,
group
3
1
No
40783000
46
40783001
46
40783002
46
°
Vegetable,
curcubit,
group
9
4
No
43062202
34
43062203
34
43282401
47
00162812
(
summary
in
92166055)
26
°
Vegetable,
fruiting,
group
8
4
No
43062201
34
43801402
45
43801406
21
00148007
(
summary
in
92166057)
26
°
Vegetable,
leafy,
except
brassica,
group
4
4
No
40375701
(
summary
in
92166059)
26
40375702
(
summary
in
92166061)
26
40375703
(
summary
in
92166058)
48
40375704
(
summary
in
92166060)
48
860.1520:
Processed
Food/
Feed
°
Alfalfa
meal
N/
A
No
42816801
49
°
Apple,
dried
and
wet
pomace
0.8
No
92166087
40576103
°
Beet,
sugar,
molasses
10
No
42839001
50
41966101
51
°
Canola/
rapeseed,
meal
40
No
42074202
27
°
Citrus,
molasses
and
dried
pulp
1.5
No
40492605
(
Summary
in
92166086)

°
Corn,
wet
and
dry
milling
N/
A
No
43178702
32
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
TABLE
6.
Residue
Chemistry
Science
Assessment
for
Reregistration
of
Sethoxydim
(
121001).

GLN
Data
Requirements
Current
Tolerances
(
ppm)
[
§
180.412]
Additional
Data
Needed?
MRID
Nos.

19
of
101
°
Cotton,
seed,
soapstock
15
No
00127281
(
Summary
in
92166078)
26
°
Flax,
meal
7
No
None
°
Grape,
raisin
2
No
43801416
21
°
Peanut,
soapstock
75
No
92166081
(
Summary
in
92166078)
26
°
Peppermint,
oil
N/
A
No
42101702
38
°
Potato,
flakes/
granules
8
No
40195102
(
Summary
in
92166082)
26
°
Potato,
processed
potato
waste
8
No
40195102
(
Summary
in
92166082)
26
°
Safflower,
meal
and
refined
oil
N/
A
No
44864501
46496901
42
°
Soybean,
meal,
hulls
and
refined
oil
N/
A
No
00100535
(
Summary
in
92166083)
26
°
Spearmint,
oil
N/
A
No
42101702
38
°
Sunflower,
meal
and
refined
oil
20
(
for
sunflower
meal)
No
00131857
(
Summary
in
92166085)
26
°
Tomato,
concentrated
products
24
No
00162633
(
Summary
in
92166080)
26
°
Tomato,
dried
pomace
12
No
00162633
(
Summary
in
92166080)
26
860.1650
Submittal
of
Analytical
Reference
Standards
N/
A
No52
N/
A
860.1850:
Confined
Accumulation
in
Rotational
Crops
N/
A
No
Accession
No.
42825
53
860.1900:
Field
Accumulation
in
Rotational
Crops
N/
A
No
41510612
53
1.
PP#
3F2904,
K.
Arne,
6/
26/
85;
Phase
V
Review,
CBRS
17851,
L.
Cheng,
4/
4/
97
2.
PP#
5F3284/
5H5475,
C.
Deyrup,
10/
9/
85;
Phase
V
Review,
CBRS
17851,
L.
Cheng,
4/
4/
97
3.
D200367,
L.
Cheng,
9/
16/
94
4.
D210046,
L.
Cheng,
1/
3/
95
5.
PP#
3F2904,
K.
Arne,
6/
26/
85;
Phase
V
review,
CBRS
17851,
L.
Cheng,
4/
4/
97;
Phase
IV,
L.
Cheng,
2/
25/
91
6.
Phase
V
review,
CBRS
17851,
L.
Cheng,
4/
4/
97;
Phase
IV,
L.
Cheng,
2/
25/
91
7.
Reviews
were
found
in:
D210060,
D210062,
D208310,
&
D208312,
M.
I.
Rodriguez,
7/
24/
95;
PP#
2F2670,
K.
Kissler,
4/
1/
83;
D257559,
N.
Dodd,
1/
24/
02;
PP#
3F2904,
11/
2/
88,
S.
Malak;
S.
Malak,
11/
7/
88;
D172349,
W.
D.
Wassell,
2/
11/
92,
memo
from
J.
Onley,
4/
1/
83
and
letter
from
M.
Bradley,
5/
4/
90
8.
PP#
0F3855,
M.
J.
Nelson,
10/
9/
91
9.
D219970,
CBRS
16310,
L.
Cheng,
4/
9/
96.
Also
summarized
in
D256970,
N.
Dodd,
8/
9/
01
10.
Phase
IV,
L.
Cheng,
2/
25/
91
11.
D203246,
L.
Cheng,
8/
15/
94
12.
Other
study
reports
were
reviewed
by
EPA;
however,
the
MRIDs
were
not
provided.
Reviews
found
in
D257559,
N.
Dodd,
1/
24/
02,
D178826,
C.
Swartz,
8/
20/
92,
and
Phase
IV,
L.
Cheng,
2/
25/
91.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
20
of
101
13.
D209952,
L.
Cheng,
1/
19/
95
14.
D200363,
L.
Cheng,
8/
22/
94
15.
PP0F3855,
M.
J.
Nelson,
2/
7/
91
and
D256970,
N.
Dodd,
8/
9/
01.
16.
PP9F3804/
PP9H5589,
S.
Inasi,
8/
8/
90
17.
D225427,
W.
Cutchin,
6/
12/
98;
D238439,
W.
Cutchin,
4/
8/
98.
18.
D183351,
D.
Davis,
12/
4/
92
19.
D193362,
D.
Davis,
8/
4/
93
20.
D197875,
D.
Davis,
4/
21/
94
21.
D237724,
L.
Cheng,
7/
28/
97
22.
D225427,
W.
Cutchin,
6/
12/
98
23.
Phase
IV,
L.
Cheng,
2/
25/
91
24.
D185410,
M.
I.
Rodriguez,
8/
25/
93
25.
D225427,
W.
Cutchin,
6/
12/
98;
D238439,
W.
Cutchin,
4/
8/
98.
26.
Phase
IV,
L.
Cheng,
2/
25/
91
27.
D171714,
D171716,
D171724,
B.
Schneider,
9/
21/
92
28.
D174374,
M.
I.
Rodriguez,
8/
7/
92
29.
PP9F3804/
PP9H5589,
S.
Inasi,
8/
8/
90
30.
D179955
&
D179957,
M.
I.
Rodriguez,
9/
16/
93
31.
Data
translated
from
parsley,
W.
Cutchin,
4/
8/
98.
32.
D210060,
D210062,
D208310,
&
D208312,
M.
I.
Rodriguez,
7­
24­
95
33.
D266208/
D266210,
N.
Dodd,
7/
5/
02
34.
D198048,
L.
Cheng,
4/
26/
94
35.
PP0E3909,
M.
J.
Nelson,
2/
14/
91
36.
Tolerance
for
horseradish
was
established
based
on
existing
residue
data
from
sugar
beets,
carrots,
potatoes
and
sweet
potatoes.
D251542,
G.
Herndon,
12/
10/
98.
37.
Residue
data
on
blueberry
and
caneberry
were
used
to
support
use
on
juneberry,
lingonberry
and
salal.
D278583,
N.
Dodd,
7/
19/
02
38.
D172349,
W.
D.
Wassell,
2/
11/
92
39.
D256970,
N.
Dodd,
8/
9/
01.
Residue
data
for
sethoxydim
on
almonds
(
nuts
and
hulls)
(
MRID
41428501),
pecans
(
MRID
41428502),
and
walnuts
(
MRID
41428503)
were
used
in
lieu
of
residue
data
on
pistachios
to
support
the
tolerance
on
pistachios.
40.
The
tolerance
for
rhubarb
is
a
regional
registration.
41.
Additional
crop
field
trials
are
needed
(
2
trials
in
Region
10)
42.
Storage
stability
data
reported
in
MRID
46496901
demonstrate
that
sethoxydim
and
its
metabolites
in
soybean
processed
fractions
(
crude
oil,
refined
oil,
and
soapstock)
remain
stable
for
at
least
29
months
under
freezer
storage
conditions
(<
­
5
C).
These
results
may
be
translated
to
cover
safflower
oil.
43.
D182749,
B.
Schneider,
11/
23/
92
44.
RCB#
943
and
#
944,
M.
Firestone,
7/
17/
85
45.
D219970,
L.
Cheng,
4/
9/
96
46.
D185410,
M.
I.
Rodriguez,
8/
25/
93
47.
D205049,
L.
Cheng,
12/
1/
94
48.
D172550,
M.
Peters,
6/
24/
92
49.
D192620,
F.
Suhre,
4/
19/
94
50.
D182748,
D182746,
D182747,
D193019,
D193020,
D193021,
W.
Wassell,
8/
6/
93
51.
D167888,
D167906,
D167908,
W.
Wassell,
2/
19/
92
52.
Replenish
standards
as
requested
by
the
repository
53.
D189273,
G.
Kramer,
8/
3/
93
860.1300
Nature
of
the
Residue
­
Plants
The
qualitative
nature
of
the
residue
in
plants
is
adequately
understood
based
on
soybean,
tomato
and
sugar
beet
metabolism
studies.
These
studies
indicate
that
sethoxydim
is
rapidly
metabolized
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
21
of
101
in
plants
to
a
multitude
of
cyclohexenone
derivatives
including
the
corresponding
parent
sulfoxide,
parent
sulfone,
their
hydroxylated
and
desethoxylated
analogs,
and
oxazole
compounds;
very
little
(

0.5%)
sethoxydim
is
left
unmetabolized.
Since
metabolism
studies
in
three
dissimilar
crops
indicate
a
similar
metabolic
route,
HED
has
concluded
that
no
additional
metabolism
studies
are
required.
The
residues
of
concern
in
plants
are
the
combined
residues
of
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
(
calculated
as
sethoxydim).
Detailed
summaries
of
the
metabolism
studies
for
soybean,
tomatoes,
and
sugar
beets
are
presented
below.
Metabolism
studies
were
also
conducted
on
alfalfa
(
MRID
00153602,
summary
in
MRID
92166044)
and
cotton
(
MRID
92166095),
however,
these
studies
are
not
discussed
in
the
document
as
they
are
not
necessary
for
the
determination
of
the
qualitative
nature
of
residue
in
plants.

For
convenience,
the
following
abbreviations
will
be
used
in
this
document
to
refer
to
sethoxydim
and
its
metabolites:

Sethoxydim
=
MS
=
2­[
1­(
ethoxyimino)
butyl]­
5­[
2­(
ethylthio)
propyl]­
3­
hydroxy­
2­
cyclohexen­
1­
one
DME
=
3­[
2­(
Ethylsulfonyl)
propyl]­
pentanedioic
acid
dimethyl
ester
DME­
OH
=
3­[
2­(
Ethylsulfonyl)
propyl]­
3­
hydroxypentanedioic
acid
dimethyl
ester
MSO
=
(
Sethoxydim
sulfoxide
metabolite.
It
is
converted
to
the
final
analyte
DME.)
=
2­
[
1­(
Ethoxyimino)
butyl]­
5­[
2­(
ethylsulfinyl)
propyl]­
3­
hydroxy­
2­
cyclohexen­
1­
one
MSO2
=
2­[
1­(
Ethoxyimino)
butyl]­
5­[
2­(
ethylsulfonyl)
propyl]­
3­
hydroxy­
2­
cyclohexen­
1­
one
M1SO
=
2­[
1­(
Imino)
butyl]­
5­[
2­(
ethylsulfinyl)
propyl]­
3­
hydroxy­
2­
cyclohexen­
1­
one
M2SO
=
6­[
2­(
Ethylsulfinyl)
propyl]­
6,7­
dihydro­
2­
propyl­
4(
5H)­
benzoxazolone
M2SO2
=
6­[
2­(
Ethylsulfonyl)
propyl]­
6,7­
dihydro­
2­
propyl­
4(
5H)­
benzoxazolone
5­
OH­
MSO2
=
(
The
most
common
hydroxylated
plant
metabolite.
It
is
converted
to
the
final
analyte
DME­
OH)
=
2­[
1­(
Ethoxyimino)
butyl]­
5­[
2­(
ethylsulfonyl)
propyl]­
3,5­
dihydroxy­
2­
cyclohexen­
1­
one
Other
metabolites
that
were
identified,
but
did
not
have
chemical
names
provided
include:
M2S
M1SO2
5­
OH­
MSO
6­
OH­
M2SO2
M1S
6­
OH­
M2SO
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
22
of
101
MGSO
MGSO2
nor­
MS
nor­
MSO
nor­
MSO2
Soybeans
MRID
92166094
(
PP#
3F2904,
K.
Arne,
6/
26/
85;
Phase
V
Review,
CBRS
17851,
L.
Cheng,
4/
4/
97)

Sethoxydim
was
labeled
with
carbon­
14
at
the
C­
4
of
the
ring
and
had
a
specific
activity
of
8.213
Ci/
mol
(
55.67
x
E9
dpm/
g).
Chemical
purity
of
the
compound
was
not
given.
Soybean
plants
received
applications
of
sethoxydim
at
a
rate
of
either
0.892
lb
ai/
A
(
0.95x
rate)
or
0.5
lb
ai/
A.
Forage
was
sampled
at
14
days
after
treatment
and
seeds
were
harvested
89
days
after
treatment.
Immediately
after
harvesting,
samples
were
placed
in
dry
ice
and
transported
to
a
laboratory
refrigerator
(­
20

C)
and
kept
there
until
analysis
(
storage
interval
estimated
to
be
about
2
years).
In
fortified
seed
(
levels
not
given),
average
recoveries
were
98
±
12%
for
parent,
100
±
8%
for
MSO2,
98
±
8%
for
M2SO2,
and
81
±
11%
for
5­
OH­
MSO2
after
freezer
storage
of
24
months.
HED
has
determined
that
sethoxydim
and
its
sulfoxide
and
sulfone
metabolites
are
stable
in
soybeans
for
3
years
(
D219970,
L.
Cheng,
4/
9/
96).

Characterization
and
identification
of
metabolites
was
completed
through
2­
dimensional
thin
layer
chromatography
(
TLC)
and
mass
spectroscopy
(
comparison
with
standards).
In
soybean
forage,
a
total
of
62%
of
total
radioactive
residue
(
TRR)
was
identified
and
in
soybean
seed,
a
total
of
72%
of
TRR
was
identified.
Of
the
remaining
residues
which
were
not
identified,
the
largest
fraction
was
the
aqueous
fraction
(
16%
in
soybean
forage
and
10%
in
soybean
seed);
however,
the
individual
fractions
accounted
for
less
than
10%
of
TRR.

The
radioactive
residues
identified
in
soybean
forage
were
MSO,
MSO2,
M2SO,
M2SO2,
M2S,
M1SO,
M1SO2,
MGSO,
and
MGSO2.
MGSO
and
MGSO2
are
ring
opened
metabolites
only
found
in
the
forage.
Metabolites
MSO
and
M2SO
were
the
major
residues
identified
at
31.3%
TRR
(
1.16
ppm)
and
13.7%
TRR
(
0.51
ppm),
respectively.
The
radioactive
residues
identified
in
soybean
seed
included
MSO,
MSO2,
M2SO,
M2SO2,
5­
OH­
MSO,
and
5­
OH­
MSO2.
Metabolites
5­
OH­
MSO
and
5­
OH­
MSO2
were
the
major
residues
identified
in
soybean
seeds
at
23.0%
TRR
(
0.119
ppm)
and
12.2%
TRR
(
0.063
ppm),
respectively.
The
amounts
of
radioactive
residues
were
higher
in
forage
than
in
seeds.

Tomatoes
MRID
00148007
(
PP#
5F3284/
5H5475,
C.
Deyrup,
10/
9/
85;
Phase
V
Review,
CBRS
17851,
L.
Cheng,
4/
4/
97)

Sethoxydim
was
labeled
at
the
C­
4
position
with
carbon­
14
with
a
specific
activity
of
13.16
mCi/
mmole.
Tomato
plants
were
treated
at
the
4­
6
trifoliate
stage
(
18
inches)
twice
with
sethoxydim
14
days
apart.
The
application
rate
was
0.5
lb
ai/
A
each
time.
Samples
were
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
23
of
101
collected
at
Days
7,
21,
35,
49
and
66
after
last
application.
The
interval
between
treatment
of
tomatoes
and
sample
analysis
was
about
24
months.
HED
has
determined
that
sethoxydim
and
its
sulfoxide
and
sulfone
metabolites
are
stable
in
tomatoes
for
3
years
(
D219970,
L.
Cheng,
4/
9/
96).

The
treated
tomatoes
were
homogenized
with
methanol
and
filtered
to
yield
a
methanolic
extract.
After
concentration
of
the
filtrate,
calcium
hydroxide
was
added
to
precipitate
protein.
After
filtration
and
concentration,
the
filtrate
was
acidified
to
pH
2
and
extracted
with
methylene
chloride.
The
acidic
aqueous
layer
was
heated
at
reflux,
cooled,
and
partitioned
with
methylene
chloride.

Metabolites
in
the
major
fraction
(
methylene
chloride)
were
identified
by
comparison
to
reference
standards
using
TLC
or
high
performance
liquid
chromatography
(
HPLC).
Depending
on
the
sampling
interval,
between
54
and
72%
of
TRR
in
tomato
fruit
was
identified.
Residues
identified
in
the
tomato
fruit
included
MSO,
MSO2,
M1SO,
M2SO,
M2SO2
and
5­
OH­
MSO2.
The
major
metabolites
were
also
confirmed
by
mass
spectroscopy.
The
total
amount
of
metabolites
in
the
methylene
chloride
fraction
from
day
35
was
also
confirmed
by
Method
30B,
which
measures
all
metabolites
containing
the
substituted
cylcohexenone
group
and
gave
a
result
of
53.4%
of
the
TRR.
When
the
aqueous
phases
(
day
35,
49,
66)
were
subjected
to
Method
30B,
<
3%
of
the
TRR
contained
the
substituted
cylcohexenone
group.

Sugar
beets
MRID
43144501,
D200367,
L.
Cheng,
9/
16/
94;
MRID
43467001,
D210046,
L.
Cheng,
1/
3/
95
A
metabolism
study
with
sugar
beets
(
MRID
00131857;
summary
in
MRID
92166042)
was
originally
conducted
using
a
dose
equivalent
to
0.45
lb
ai/
A.
As
the
dose
applied
only
represented
about
½
the
registered
seasonal
rate,
HED
requested
that
another
sugar
beet
study
be
conducted
at
the
registered
use
rate
(
L.
Cheng,
2/
25/
91).
In
response,
a
new
sugar
beet
study
was
submitted
(
MRID
43144501).
In
this
study,
sethoxydim
was
labeled
with
carbon­
14
at
the
C­
4
of
the
cylcohexene
ring
(
94%
radiopurity
and
a
specific
activity
of
60.97

Ci/
mg).
A
spray
solution
was
prepared
in
crop
oil
concentrate
and
water
in
proportions
similar
to
a
typical
spray
tank
mixture.
One
hundred
and
13
days
after
planting,
6
sugar
beet
plants
were
sprayed
until
the
foliage
was
thoroughly
covered
with
formulated
sethoxydim
at
a
rate
equivalent
to
1
lb
ai/
A.
Six
plants
also
served
as
control.

Samples
were
collected
at
0,
60,
and
100
days
after
treatment.
The
plants
were
separated
into
tops
and
roots.
The
samples
were
stored
frozen
at
­
20

C
at
until
analysis.
Chemical
analysis
lasted
18
months
(
6/
92
to
12/
93).

Crop
samples
were
extracted
with
methanol
and
aqueous
methanol
that
yielded
ca
90­
93%
TRR.
The
fibrous
residue
left
was
then
extracted
with
methanol:
chloroform
and
acetone
that
yielded
0.4­
0.5%
TRR.
The
methanol
and
aqueous
methanol
fractions
were
combined,
reduced
in
volume,
diluted
with
water,
and
extracted
at
pH
2
with
dichloromethane.
The
organosoluble
residues
were
separated
into
neutral
and
acidic
compounds
by
partitioning
with
aqueous
sodium
hydroxide
followed
by
back
extraction
into
hexane
and
then
dichloromethane.
The
aqueous
fractions
were
combined,
passed
through
Amberlite
XAD­
4
columns,
treated
with
pectinase,
and
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
24
of
101
the
released
exocons
were
extracted
into
dichloromethane.
Residues
remaining
in
the
aqueous
solution
were
methylated
and
then
extracted
into
dichloromethane.
The
final
aqueous
phase
was
subjected
to
the
residue
analytical
method
to
determine
any
sethoxydim
related
compounds
left.
The
non­
extractable
residues
(
9%
TRR
for
tops
and
6%
for
roots)
were
reacted
with
polysaccharide
hydrolyzing
enzymes
(
cellulase,
pectolyase,
driselase).

One­
and/
or
two­
dimensional
TLC
analyses
were
used
for
the
separation
and
detection
of
sethoxydim
metabolites
(
through
Rf's
of
known
standards).
Regions
of
silica
gel
corresponding
to
individual
metabolites
were
scraped
off
and
the
radioactivity
was
determined
by
a
liquid
scintillation
counter.
Aliquots
of
liquid
or
TLC
silica
gel
samples
were
mixed
with
a
scintillation
cocktail
and
assayed
directly
and
fibrous
residues
were
oxidized
and
the
trapped
carbon
dioxide
was
mixed
with
a
scintillation
cocktail
and
then
assayed.
DME,
DME­
OH,
MSO,
and
MSO2
were
detected
by
UV
365
nm
after
spraying
with
0.01%
purimulin
in
80%
acetone,
and
the
others
by
254
nm
directly
without
spraying.
The
identity
of
many
metabolites
was
confirmed
by
HPLC
retention
time
and/
or
LC­
MS.

Initial
dichloro­
methane
extractions
(
DCM
I:
acidic
M
type,
&
DCM
II:
neutral
M1,
M2
type)
removed
about
half
or
more
of
the
TRR.
Other
fractions
that
released
any
significant
amount
of
TRR
(>
10%
TRR)
were
from
the
methylation
and
oxidation/
methylation
step.

The
metabolites
identified
and
characterized
included
sethoxydim,
MSO2,
5­
OH­
SO2,
5­
OH­
SO,
MSO,
M2SO2,
M2SO,
6­
OH­
M2SO2,
M1SO2,
M1S,
M1SO,
M2S,
and
6­
OH­
M2SO.

The
registrant
submitted
photographs
of
sample
TLC's,
HPLC's,
and
LC­
MS
to
support
metabolite
characterization.
Two­
dimensional
TLC's
were
submitted
to
support
structural
assignment
of
the
residues
extracted
into
the
early
dichloromethane
fractions
(
DCM­
I
&
II)
for
sugar
beet
top
and
root.
Identification
was
through
comparison
of
Rf
values
of
various
mixtures
of
known
standards.
The
extracted
samples
were
carried
through
2­
dimensional
TLC
and
mixtures
of
certain
standards
and
samples
were
analyzed
in
two
different
solvent
systems.
HPLC's
for
standards
MSO2,
MSO,
M2SO2,
M1SO2,
and
M2SO
were
submitted.
However,
mass
specs
of
the
MSO2
(
a
major
component)
fractions
isolated
from
sugar
beet
tops
and
roots
were
not
superimposable
with
those
of
the
standards;
there
were
either
extraneous
peaks
(
see
p
206)
or
vastly
different
ion
ratios
(
p
207).
In
a
follow­
up
submission
(
MRID
43467001)
the
registrant
indicated
that
the
extraneous
peaks
seen
in
the
mass
spectra
were
due
to
impurities
in
the
sugar
beet
samples.
The
performing
laboratory
re­
analyzed
reserved
samples
of
sugar
beet
top
and
root.
Mass
spectra
of
the
samples
showed
the
same
peaks
as
the
MSO2
standard
with
similar
peak
intensities.
It
was
pointed
out
that
even
the
relative
peak
intensities
of
the
standard
injected
at
two
different
times
varied.
HED
concluded
that,
with
the
2­
dimensional
TLC
analyses
submitted
in
the
original
report
and
the
additional
mass
spec
information,
the
identity
of
MSO2
as
one
of
the
metabolites
found
in
sugar
beet
top
and
root
has
been
confirmed.

Stability
data
under
frozen
conditions
(­
16

C)
for
sethoxydim
residues
were
also
provided
by
the
registrant.
Aliquots
(
10­
50
g
sugar
beet
top
or
25­
50
g
root)
of
the
60­
day
PHI
sample
from
the
metabolism
study
were
removed
at
various
intervals
during
frozen
storage,
extracted,
and
analyzed
by
TLC.
TLC
profiles
showed
that
levels
of
sethoxydim,
MSO2,
5­
OH­
SO2,
and
M1
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
25
of
101
and
M2
type
of
metabolites
in
the
top
and
root
remained
relatively
constant
for
20
months.
Additional
experiments
were
conducted
in
which
the
sugar
beet
top
and
root
samples
after
extraction
were
oxidized
and
methylated.
This
process
converted
sethoxydim
residues
to
DME
and
DME­
OH.
Amounts
of
DME
and
DME­
OH,
expressed
in
%
TRR,
were
quantitated
by
TLC.

The
426­
day
sugar
beet
top
sample
and
the
393­
day
sugar
beet
root
sample
were
also
quantitated
by
GC
residue
method
(
Method
30B)
to
check
the
accountability
of
sethoxydim
residues
in
plant
commodities.
Method
30B
converts
sethoxydim
residues
to
DME
and
DME­
OH
through
oxidation
and
methylation.
It
accounted
for
46%
of
TRR
in
sugar
beet
top
and
root.
Concurrent
recoveries
ranged
68­
102%
for
sethoxydim
and
5­
OH­
MSO2
in
sugar
beet
top
and
root.
The
stability
data
support
the
validity
of
the
metabolism
results
obtained
from
samples
that
were
stored
frozen
for
18
months.

860.1300
Nature
of
the
Residue
­
Livestock
(
D257559.
MEM.
wpd)

The
nature
of
the
residue
in
livestock
is
understood
based
on
acceptable
metabolism
studies
in
ruminants
(
goat)
and
poultry
(
hens).
The
residues
of
concern
in
animal
commodities
are
the
combined
residues
of
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety.

Ruminants
MRID
00153602
(
Summary
in
MRID
92166046)
(
PP#
3F2904,
K.
Arne,
6/
26/
85;
Phase
V
Review,
CBRS
17851,
L.
Cheng,
4/
4/
97)

Adequate
ruminant
metabolism
data
are
available
(
Phase
V
Review,
CBRS
17851,
L.
Cheng,
4/
4/
97).
A
lactating
goat
was
fed
14C­
ring­
labeled
sethoxydim
sulfoxide
(
14C­
MSO)
for
5
consecutive
days
at
100
ppm
in
the
dry
diet.
HED
notes
that
this
is
equivalent
to
1.3x
of
the
expected
dietary
burden
of
75
ppm.
The
residues
in
milk,
liver,
and
kidney
were
identified.
The
residues
in
muscle
and
fat
were
not
identified.
Analyses
of
samples
were
completed
in
2­
3
months.
The
study
indicated
that
sethoxydim
sulfoxide
(
MSO)
was
oxidized
to
the
corresponding
sulfone
(
MSO2)
followed
by
desethylation
with
subsequent
methylation
at
the
sulfur
atom
to
form
several
nor­
compounds
(
nor­
MS,
nor­
MSO,
and
nor­
MSO2).
These
nor­
compounds
were
found
in
small
quantities
in
milk,
liver
and
kidney.
In
milk
and
kidney,
the
major
residues
were
MSO
and
MSO2.
The
major
residues
in
liver
were
MSO2
and
sethoxydim.
Sethoxydim
was
found
in
kidney
and
liver,
but
not
in
the
milk
(
D257559,
N.
Dodd,
1/
24/
02).

In
the
Phase
4
Review
(
L.
Cheng,
2/
25/
91),
HED
required
the
registrant
to
submit
a
new
ruminant
metabolism
study
using
the
parent,
sethoxydim,
for
feeding.
This
requirement
was
later
waived
by
HED
(
D165957,
D169251
&
D170139,
C.
Swartz,
1/
24/
92).

Poultry
MRID
00155129
(
Summary
in
MRID
92166047)
(
Phase
V
Review,
CBRS
17851,
L.
Cheng,
4/
4/
97)
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
26
of
101
Adequate
poultry
metabolism
data
are
available
through
two
poultry
metabolism
studies.
In
one
poultry
metabolism
study,
laying
hens
were
dosed
with
14C­
sethoxydim
sulfoxide
(
ring­
labeled
at
the
C4
and
C6
positions)
at
50
ppm
for
7
days
in
the
diet.
HED
notes
that
this
dose
is
equivalent
to
4.2x
of
the
theoretical
dietary
burden
of
12
ppm.
Residue
analyses
on
eggs
and
liver
were
completed
in
2
months.
The
major
residues
in
eggs
and
liver
were
MSO
and
MSO2.
In
a
subsequent
submission
(
8
months
later)
(
RCB
#
306,
S.
Malik,
6/
23/
86),
frozen
samples
of
liver,
muscle,
skin,
and
fat
from
the
above
study
were
analyzed
for
sethoxydim
residues.
The
major
residues
in
muscle,
fat,
skin,
and
liver
were
MSO
and
MSO2.
M1SO
was
also
found
in
muscle,
fat,
and
liver.

In
a
second
poultry
metabolism
study,
10
laying
hens
were
dosed
with
14C­
sethoxydim
(
ringlabeled
at
the
C­
4
and
C­
6
position
of
the
ring)
at
200
ppm
in
the
diet.
Analysis
was
completed
in
2
months.
MSO,
MSO2,
and
MS
were
found
in
muscle,
fat,
and
liver.
The
major
residues
were
MSO
and
MSO2
in
muscle
and
liver,
and
MSO
and
MS
in
fat
(
D257559,
N.
Dodd,
1/
24/
02).

In
the
Phase
IV
review
HED
also
noted
that
the
registrant
failed
to
characterize
radioactive
residues
in
eggs
from
hens
fed
with
the
parent
and
requested
an
additional
poultry
metabolism
study.
However,
HED
later
waived
the
requirement
for
an
additional
hen
metabolism
study
noting
that
residues
were
well
characterized
and
well
identified
in
the
two
submitted
poultry
metabolism
studies;
additional
metabolites
of
toxicological
concern
would
be
likely
to
contain
the
2­
cyclohexen­
1­
one
moiety,
and
the
analytical
method
would
detect
any
species
containing
this
moiety
(
D165957,
D169251
&
D170139,
C.
Swartz,
1/
24/
92).

860.1300
Nature
of
the
Residue
­
Water
The
Metabolism
Assessment
Review
Committee
(
MARC)
discussed
residues
of
the
herbicide
sethoxydim
in
water
on
5/
14/
98.
The
likely
degradates
in
soil
and
water
were
described
at
the
meeting
by
Jim
Breithaupt,
EFED.
The
predominant
degradates
in
soil
are
the
sulfoxide
and
sulfone
derivatives
of
the
parent
(
MSO,
MSO2).
Those
degradates
are
expected
to
be
found
in
water
along
with
M1S
(
loss
of
ethoxy
group
on
imino
nitrogen)
and
M2S
(
formation
of
oxazole
ring).
Toxicology
data
for
the
four
degradates
expected
in
water
do
not
appear
to
be
available.
In
the
absence
of
such
data,
the
MARC
concluded
that
these
degradates
should
be
considered
as
having
comparable
toxicity
as
the
parent.
Therefore,
for
risk
assessment
purposes,
the
residues
in
water
are
the
"
total
sethoxydim
residues"
in
water
(
i.
e.,
parent
plus
degradates).
(
Metabolism
Assessment
Review
Committee
meeting
on
5/
14/
98;
R.
Loranger
memo
dated
5/
27/
98).

860.1340
Residue
Analytical
Methods
(
D257559.
MEM.
wpd)

BASF
Wyandotte
Corporation's
(
BWC's)
Methods
No.
30,
30G,
30H
and
A9003
are
adequate
analytical
methods
for
data
collection
and/
or
enforcement
of
tolerances
for
residues
of
sethoxydim
and
its
metabolites
in
or
on
plant
and
animal
commodities.
Summaries
of
these
methods
are
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
27
of
101
provided
below.

Method
30
BWC's
Method
No.
30,
"
Determination
of
BAS
9052H
and
its
Metabolites
in
Soybean
Seed,
Soybean
Seed
Process
Fractions,
Chicken
Tissues,
Beef
Tissues,
Milk
and
Eggs",
is
designed
to
determine
residues
of
sethoxydim
and
its
metabolites,
including
the
parent
sulfoxide
(
MSO),
the
parent
sulfone
(
MSO2)
and
hydroxylated
derivatives
(
e.
g.
5­
OH­
MSO2).
Residues
are
determined
as
3­[
2­(
ethylsulfonyl)­
propyl]
pentanedioic
acid
dimethyl
ester
(
DME)
and
its
3­
hydroxy
derivative,
3­[
2­(
ethoxysulfonyl)
propyl]­
3­
hydroxypentanedioic
acid
dimethyl
ester
(
DME­
OH),
respectively.
The
limit
of
quantitation
for
each
analyte
is
reported
to
be
0.05
ppm
sethoxydim
equivalents.
Method
30
is
included
as
Method
I
in
PAM
II.
In
Method
30,
samples
are
extracted
with
aqueous
methanol,
methanol,
or
acetonitrile,
depending
on
the
sample
matrix.
The
sample
extracts
are
cleaned
up
by
alkaline
precipitation
and
acidic
back
extraction
and
then
partitioned
with
methylene
chloride.
Sethoxydim
and
its
metabolites
are
oxidized
to
3­[
2­
(
ethoxysulfonyl)
propyl]
pentanedioic
acid
and
3­[
2­(
ethoxysulfonyl)
propyl]­
3­
hydroxypentanedioic
acid
and
then
derivatized
to
DME
and
DME­
OH,
respectively.
The
derivatives
are
partitioned
into
methylene
chloride
and
cleaned
up
by
silica
gel
column
chromatography.
Some
samples
require
an
additional
HPLC
cleanup.
DME
and
DME­
OH
are
determined
by
GLC
with
flame
photometric
detection.

Successful
EPA
petition
method
validation
trials
were
conducted
for
Method
30
on
soybeans,
beef
liver,
and
milk.
In
the
soybean
validation
trial,
EPA
obtained
recoveries
of
73­
85%
for
sethoxydim
and
the
metabolites
MSO2,
M2SO2,
and
5­
OH­
MSO2
from
duplicate
soybean
samples
fortified
with
each
compound
at
0.1
ppm.
Two
trials
were
conducted
with
beef
liver
and
milk.
In
one
trial,
EPA
obtained
recoveries
of
92­
95%
for
sethoxydim
and
M2SO2,
each
added
to
duplicate
beef
liver
samples
at
0.2
ppm.
Recoveries
of
MSO2
and
5­
OH­
MSO2,
each
added
to
duplicate
milk
samples
at
0.05
ppm,
were
72­
90%
(
PP#
2F2670,
K.
Kissler,
4/
1/
83;
D257559,
N.
Dodd,
1/
24/
02).
In
the
other
trial,
Method
30
was
determined
to
be
adequate
for
residue
determination
of
the
metabolites
M1SO,
nor­
MSO,
and
nor­
MSO2
in
milk
and
livestock
tissue.
Recoveries
of
the
metabolites
ranged
from
70
to
107%
in
milk
fortified
at
levels
of
0.05
and
0.1
ppm
and
from
68
to
100%
in
beef
liver
fortified
at
levels
of
0.2
and
0.4
ppm
(
PP#
3F2904,
11/
2/
88,
S.
Malak).
The
results
were
forwarded
to
FDA
for
updating
the
Method
I
entry
in
PAM
II
(
S.
Malak,
11/
7/
88).

Method
30G
and
30H
BWC's
Method
30G
"
Addendum
to
BWC
Agricultural
Chemicals
Method
No.
30
for
the
Determination
of
BAS
9052H
and
its
Metabolite
Residues
in
Alfalfa
Forage
and
Soybean
Forage"
and
Method
30H
"
Addendum
to
BWC
Agricultural
Chemicals
Method
No.
30
for
the
Determination
of
BAS
9052H
and
its
Metabolite
Residues
in
Alfalfa
Hay
and
Soybean
Hay"
are
common
moiety
methods
and
are
essentially
similar
to
Method
No.
30,
except
that
both
methods
skip
the
methylene
chloride
partition
step
just
before
oxidation.
Method
30G
is
designed
for
determination
of
residues
of
sethoxydim
and
its
metabolites
in
succulent
commodities,
forages,
fruits
and
vegetables;
the
limit
of
detection
is
0.05
ppm
sethoxydim
equivalents
(
0.1
ppm
for
citrus
process
products,
succulent
beans
and
peas).
Method
30H
is
designed
for
analysis
of
residues
of
sethoxydim
and
its
metabolites
in
dry
commodities,
hay,
flax
products,
dry
grape
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
28
of
101
products
(
raisins,
raisin
waste
and
dry
pomace),
dry
potato
process
products
and
sugar
beet
tops;
the
limit
of
detection
is
0.05
ppm
sethoxydim
equivalents
(
0.1
ppm
for
grape
and
potato
process
products).
Methods
30G
and
30H
were
submitted
for
publication
in
PAM
II
(
see
letter
from
M
Bradley,
EPA
to
A.
Marcotte,
FDA,
5/
4/
90)
as
Method
A
and
B,
respectively;
however,
they
have
not
as
of
this
time
appeared
in
PAM
II.

Method
A9003
BWC's
Method
A9003
is
chemically
similar
to
BASF
Methods
30G
and
30H;
the
primary
innovation
in
Method
A9003
is
the
transfer
of
the
analyte
from
an
aqueous
solution
into
activated
charcoal
prior
to
methylation.
Briefly,
sethoxydim
and
its
metabolites
are
extracted
from
the
matrix
with
an
isopropanol/
water
mixture.
A
calcium
hydroxide
precipitation
step
follows.
The
extract
is
then
oxidized
using
hydrogen
peroxide.
After
phase
separation,
the
acids
are
isolated
from
the
aqueous
phase
by
charcoal
treatment
and
subsequently
converted
to
their
dimethyl
esters.
Sample
purification
is
accomplished
by
silica
gel
column
chromatography
and
C
18
solid
phase
extraction,
if
necessary.
Final
determination
is
made
by
gas
chromatography
with
sulfur
detection.
Alfalfa
hay,
spinach,
poultry
meat,
corn
grain,
tomato,
and
apple
were
used
in
the
validation.
The
method
was
not
successful
with
soybeans
or
most
other
oily
matrices.
Samples
were
fortified
on
the
day
of
the
analysis
with
metabolites
MSO
and
5­
OH­
MSO2
at
levels
ranging
from
0.05
to
50
ppm.
Overall,
mean
recoveries
were
83%
for
MSO
and
81%
for
5­
OH­
MSO
2.
Since
the
method
was
not
considered
acceptable
for
soybeans,
the
overall
mean
recoveries
do
not
include
percent
recoveries
for
soybeans.
The
limit
of
quantitation
for
spinach,
poultry
meat,
corn
grain,
tomato,
and
apple
was
0.05
ppm
for
each
analyte.
The
limit
of
quantitation
for
alfalfa
hay
was
0.5
ppm
for
each
analyte.
HED
noted
that
Method
A9003
would
be
sent
to
FDA
for
inclusion
in
Pesticide
Analytical
Manual
(
PAM)
II
as
a
lettered
method
(
D210060,
D210062,
D208310,
&
D208312,
M.
I.
Rodriguez,
7/
24/
95).

Method
278
It
should
be
noted
that
in
the
crop
field
trials
for
mint,
samples
were
analyzed
by
BASF
Method
278,
which
is
a
slightly
modified
version
of
BASF
Method
30G
and
30H
(
D172349,
W.
D.
Wassell,
2/
11/
92
­
file
R066020).
In
this
method,
the
samples
are
soaked
in
water
and
extracted
with
isopropanol.
The
extract
is
precipitated
and
oxidized
as
in
Methods
30G
and
30H.
A
modification
includes
an
isolation
of
the
residues
utilizing
charcoal
adsorption.

860.1360
Multiresidue
Methods
Multiresidue
data
for
sethoxydim,
sethoxydim
sulfoxide
(
MSO),
and
5­
hydroxy
sethoxydim
sulfone
(
5­
OH­
MSO2)
were
submitted
by
the
registrant
in
MRID
4198701.
Only
protocols
C,
D,
and
E
were
tested
since
protocols
A
and
B
were
not
applicable.
Under
current
guidelines,
protocol
G
is
also
not
applicable.
Sethoxydim
and
sethoxydim
sulfoxide
(
MSO)
chromatographed
through
Protocol
C
but
did
not
elute
through
Florisil;
therefore,
these
analytes
could
not
be
recovered
through
Protocols
D
and/
or
E.
On
the
other
hand,
5­
hydroxy
sethoxydim
sulfone
(
5­
OH­
MSO2)
did
not
chromatograph
through
Protocol
C.
The
registrant
concluded
that
sethoxydim
and
its
metabolites
are
not
amenable
to
the
multiresidue
test
procedures
defined
in
PAM
I.
The
results
were
forwarded
to
FDA
for
evaluation
and
inclusion
in
PAM,
Vol
I,
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
29
of
101
Appendix
I.
(
PP#
0F3855
and
0E3900,
M.
J.
Nelson,
10/
9/
91).

The
FDA
PESTDATA
database
dated
10/
99
(
PAM
Volume
I,
Appendix
I)
indicates
that
sethoxydim
and
sethoxydim
sulfone
are
not
recovered
through
protocol
E
(
Section
303)
or
protocol
F
(
Section
304).

860.1380
Storage
Stability
Plant
Commodities
(
D256970.
DER.
wpd)

The
Phase
IV
review,
HED
indicated
that
data
were
available
to
demonstrate
the
stability
of
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
in
several
commodities
for
14
to
60
months
of
frozen
storage.
However,
the
Sethoxydim
Phase
IV
review
was
issued
prior
to
the
investigation
of
the
validity
of
data
generated
by
Craven
Laboratories.
As
a
result
of
the
Craven
investigation,
HED
assessed
the
impact
Craven­
data
had
on
sethoxydim
registrations.
With
respect
to
storage
stability
data,
HED
concluded
that
non­
Craven
frozen
storage
stability
data
for
sethoxydim
and
its
metabolites
in
soybean
seeds,
tomatoes,
apples,
oranges,
and
potatoes
are
available
for
up
to
36
months
and
are
adequate
to
profile
sethoxydim
and
its
metabolites
in
various
crops
(
D165411,
L.
Cheng,
9/
23/
91).
For
soybean
seeds,
the
data
indicate
that
residues
of
parent,
MSO2,
M2SO2,
and
5­
OH­
MSO2
are
stable
for
only
up
to
24
months
(
D256970,
N.
Dodd,
8/
9/
01).

In
response
to
a
Data
Call­
In
(
DCI)
regarding
the
replacement
of
the
data
generated
by
Craven
Laboratories,
the
registrant
submitted
freezer
storage
stability
data
for
sethoxydim
and
its
metabolites
in
13
representative
fruit
and
vegetable
crops.
In
these
studies
(
MRIDs
43801401,
43801402,
43801403,
43801404
and
438014015),
untreated
control
samples
of
corn
grain,
corn
forage,
cherry,
orange,
strawberry,
potato,
onion,
lettuce,
apple,
succulent
bean,
and
dry
bean
from
previous
field
trials
and
those
of
tomatoes
and
cucumbers
purchased
from
local
supermarkets
were
fortified
with
MSO
and
with
MSO2.
Initial
screening
of
the
control
samples
indicated
that
most
matrices
were
free
of
any
interfering
residues
with
residues
<
0.01
ppm
(
cherries,
oranges,
strawberries,
potatoes,
lettuce,
tomatoes,
and
apples).
The
remaining
matrices
(
corn
grain,
corn
forage,
onion,
cucumber,
succulent
bean,
and
dry
bean)
bore
0.05
ppm
or
less
contaminants
which
appeared
at
similar
retention
times
on
gas
chromatography
as
DME
and
DME­
OH.
These
levels
were
considered
insignificant
when
compared
to
the
1­
10
ppm
fortification
levels.

Samples
were
fortified
with
a
solution
containing
either
1,
2,
3,
or
10
ppm
of
MSO
and
1,
2,
3,
or
10
ppm
of
5­
OH­
MSO2.
The
fortified
samples
and
the
large
composite
samples
of
control
materials
were
then
transferred
to
a
freezer
where
they
were
kept
at
­
5

C
until
analysis.
On
the
day
of
each
analysis,
two
aliquots
of
stored
fortification
samples
and
two
control
samples
were
removed
from
the
freezer
for
analysis.
One
or
two
aliquots
of
the
control
material
were
weighed
out
and
used
for
procedural
fortifications.
Each
of
these
two
procedural
fortification
(
concurrent
recovery)
samples
was
fortified
with
1.0
(
corn
grain,
corn
forage,
cherries,
oranges,
potatoes,
onions,
lettuce,
cucumbers,
and
apples),
2.0
(
strawberries),
3.0
(
tomatoes),
or
10.0
(
succulent
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
30
of
101
beans
and
dry
beans)
ppm
each
of
MSO
and
5­
OH­
MSO2.

The
corn
grain
and
dry
bean
were
analyzed
by
Method
30.
The
remaining
crop
matrices
were
analyzed
by
Method
30B.
The
limit
of
quantitation
for
Method
30
and
30B
for
all
thirteen
crop
matrices
was
given
as
0.05
ppm
per
metabolite.
For
MSO,
recoveries
of
the
stored
samples
from
all
crop
matrices
were
not
significantly
different
from
those
fortified
on
the
days
of
analysis
throughout
the
test
period.
For
5­
HO­
MSO2,
acceptable
recoveries
were
obtained
in
most
crop
matrices
throughout
the
test
period
except
in
cherries,
strawberries,
potatoes,
tomatoes,
and
succulent
bean.

MSO
was
stable
in
corn
grain
and
forage,
lettuce,
oranges,
tomatoes,
cucumbers,
succulent
and
dry
beans,
potatoes,
onions,
apples,
cherries,
and
strawberries
for
5
years
under
frozen
storage
(<­
5

C).
5­
OH­
MSO2
was
less
stable
than
MSO
in
acidic
matrices:
5­
OH­
MSO2
was
stable
in
cherries,
strawberries,
and
tomatoes
for
3
years,
in
succulent
beans
and
potatoes
for
4
years,
and
in
corn
grain
and
forage,
lettuce,
oranges,
cucumbers,
dry
beans,
onions,
and
apples
for
5
years
under
frozen
storage.
(
D219970,
L.
Cheng,
4/
9/
96).

HED
indicated
that
the
replacement
storage
stability
studies
did
not
include
an
oil
seed
(
soybean
or
nut)
crop.
However,
non­
Craven
storage
stability
data
for
soybeans
was
submitted
previously
and
demonstrates
stability
of
sethoxydim
and
it's
metabolites
for
up
to
24
months.

Animal
commodities
A
study
to
document
the
stability
of
sethoxydim
metabolites
(
MSO,
non­
hydroxylated,
and
5­
OHMSO2
hydroxylated)
in
livestock
matrices
under
frozen
conditions
was
conducted
by
the
registrant
(
MRID
43223401).
In
this
study,
whole
bovine
milk,
chicken
eggs,
ground
beef
(
30%
fat),
chicken
breasts
with
bone
and
skin,
beef
liver,
and
beef
kidney
were
purchased
from
a
local
grocer.
No
further
sample
preparation
was
necessary
for
the
milk
and
ground
beef.
The
white
and
yolk
of
eggs
were
homogenized;
the
chicken
breasts
were
deboned,
cut
into
strips
(
with
skin),
and
ground
up
in
a
meat
grinder.
The
beef
kidney
and
liver
were
cut
into
strips
and
fed
through
the
meat
grinder.
All
samples
were
prepared
after
thawing
but
while
still
cold.
Aliquots
of
each
matrix
were
selected
as
control,
or
fortified
with
(
nominally)
1
ppm
of
MSO
or
1
ppm
5­
OHMSO
2
as
procedural
and
storage
samples.
The
samples
were
kept
at
­
5

C
or
colder
and
analyzed
at
intervals
of
0,
3,
6,
12,
18,
and
25
months
(
D203246,
L.
Cheng,
8/
15/
94).

Samples
were
agitated
with
methanol
in
a
blender
and
then
concentrated
to
near
dryness.
Calcium
hydroxide
was
added
(
yielding
precipitation)
and
the
mixture
was
filtered.
The
filtrate
was
acidified,
extracted
with
dichloromethane
and
evaporated
to
dryness.
The
residues
were
oxidized
with
alkaline
hydrogen
peroxide
and
any
excess
oxidizing
agent
was
quenched
enzymatically.
The
oxidized
products
were
converted
to
methyl
esters
with
sulfuric
acid
and
methanol,
and
excess
acid
was
quenched
with
saturated
sodium
bicarbonate.
The
two
esters
(
DME
and
OH­
DME)
were
extracted
into
dichloromethane.
All
samples
were
purified
through
a
silica
gel
and/
or
C
18
solid
phase
column
before
GC
analysis
(
FPD
in
the
sulfur
mode).
The
limit
of
quantitation
of
all
analyses
was
0.05
ppm
for
either
metabolite.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
31
of
101
Percent
recoveries
of
MSO
and
5­
OH­
MSO2
in
all
the
matrices
tested
were
generally
in
the
80­
90%
range.
HED
concluded
that
residues
of
sethoxydim,
hydroxylated
and
non­
hydroxylated
are
stable
in
livestock
commodities
under
frozen
conditions
for
26
months
(
D203246,
L.
Cheng,
8/
15/
94).

860.1400
Water,
Fish,
and
Irrigated
Crops
Sethoxydim
is
not
presently
registered
for
direct
use
on
water
and
aquatic
food
and
feed
crops;
therefore,
no
residue
chemistry
data
are
required
under
these
guideline
topics.

860.1460
Food
Handling
Sethoxydim
is
not
presently
registered
for
use
in
food­
handling
establishments;
therefore,
no
residue
chemistry
data
are
required
under
this
guideline
topic.

860.1480
Meat,
Milk,
Poultry,
and
Eggs
(
D257559.
MEM.
wpd)

Feeding
studies
with
lactating
dairy
cows
(
administered
0.60
or
50.0
ppm
sethoxydim
for
30
days)
and
laying
hens
(
fed
1,
10,
or
100
ppm
sethoxydim
for
30
days)
were
submitted
in
connection
with
PP#
0G2396
(
E.
Zager,
12/
4/
80).
However,
because
the
dose
levels
in
the
cattle
feeding
study
were
less
than
the
computed
dietary
burden
for
cattle
(
see
Table
7),
data
from
a
75
ppm
goat
feeding
study
were
used
for
the
analysis
that
follows.

Dietary
burdens
were
calculated
assuming
reasonably
balanced
diets
comprised
of
roughage,
protein
concentrate,
and
carbohydrate
concentrate
for
cattle,
and
protein
concentrate
and
carbohydrate
concentrate
for
swine
and
poultry.
These
diets
and
their
resulting
dietary
burdens
are
presented
in
Tables
7
and
8.

Table
7.
Calculated
theoretical
dietary
burden
of
sethoxydim
for
beef
and
dairy
cattle.

Feedstuff
Tolerance
level
(
ppm)
%
Dry
Matter
Beef
&
Dairy
Cattle
%
of
Diet
Dietary
Burden
(
ppm)

Alfalfa,
forage
40
35
50
57
Sunflower,
meal
20
92
15
3.3
Beet,
sugar,
molasses
10
75
10
1.3
Potato,
processed
waste
8
15
25
13.3
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Table
7.
Calculated
theoretical
dietary
burden
of
sethoxydim
for
beef
and
dairy
cattle.

Feedstuff
Tolerance
level
(
ppm)
%
Dry
Matter
Beef
&
Dairy
Cattle
%
of
Diet
Dietary
Burden
(
ppm)

32
of
101
Total
for
diet
100
74.9
Table
8.
Calculated
theoretical
dietary
burden
of
sethoxydim
for
poultry
and
swine
Feedstuff
Tolerance
Level
(
ppm)
Poultry
Swine
%
Diet
Burden
(
ppm)
%
Diet
Burden
(
ppm)

canola
meal
40
15
6
15
6
Corn,
field,
grain
0.5
85
0.43
85
0.43
Total
100
6.4
100
6.4
In
lactating
goats
fed
hay
containing
75
ppm
sethoxydim
for
28
days
(
PP#
8F3640/
8H5557,
H.
Fonouni,
11/
4/
88;
PP#
4F04344,
D208310,
M.
Rodriguez,
7/
24/
95),
residues
of
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
were
<
0.05
ppm
in
muscle
and
fat,
<
0.44
ppm
in
kidney,
0.14
ppm
in
liver,
and
<
0.01­
0.18
ppm
in
milk.
The
maximum
residue
levels
measured
in
each
tissue
are
summarized
below
in
Table
9
and
used
to
computed
the
maximum
potential
sethoxydim
residue
level
in
each
tissue
assuming
a
dietary
burden
of
75
ppm
for
cattle.

Table
9.
Maximum
potential
sethoxydim
residue
levels
based
on
lactating
goat
feeding
study.

Matrix
Max
sethoxydim
residue
at
75
ppm
dosing
level
T/
Fa
Dietary
Burden
(
ppm)
Max
potential
sethoxydim
level
(
ppm)
b
Muscle
<
0.05
0.000667
75
<
0.05
Fat
<
0.05
0.000667
75
<
0.05
Kidney
<
0.44
0.00587
75
<
0.44
Liver
0.14
0.00187
75
0.14
Milk
0.18
0.00240
75
0.18
a
Tissue
to
feed
ratio
calculated
as
maximum
sethoxydim
residue
level
in
the
indicated
tissue
divided
by
the
75
ppm
dosing
level.
b
Determined
by
multiplying
the
T/
F
value
and
the
dietary
burden.

In
the
poultry
feeding
study,
no
detectable
residues
were
reported
for
muscle
samples
from
the
1.0
or
10.0
ppm
dosage
level.
Residue
levels
of
<
0.05­
0.19
ppm
were
found
in
muscle
tissues
from
the
100
ppm
level.
In
poultry
liver,
residues
of
<
0.05­
0.34
ppm
and
0.23­
0.47
ppm
were
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
33
of
101
found
in
samples
from
the
10
and
100
ppm
feeding
levels,
respectively.
In
eggs,
residue
values
of
<
0.05­
0.34
were
reported
for
the
10
ppm
feeding
level,
and
<
0.05­
1.88
ppm
for
the
100
ppm
feeding
level
(
PP#
9F3806,
L.
Rodriguez,
2/
27/
90;
PP#
0G2396,
E.
Zager,
12/
4/
80).

Table
10.
Maximum
potential
sethoxydim
residue
levels
based
on
poultry
feeding
study.

Matrix
Max
sethoxydim
residue
at
10
ppm
dosing
level
T/
Fa
Dietary
Burden
(
ppm)
Max
potential
sethoxydim
level
(
ppm)
b
Muscle
0.11
0.011
6.4
0.07
Liver
0.17
0.017
6.4
0.11
Eggs
0.34
0.034
6.4
0.22
a
Tissue
to
feed
ratio
calculated
as
maximum
sethoxydim
residue
level
in
the
indicated
tissue
divided
by
the
10
ppm
dosing
level.
b
Determined
by
multiplying
the
T/
F
value
and
the
dietary
burden.

Based
on
the
feeding
study
results
and
the
dietary
burden
calculations,
secondary
residues
in
livestock
commodities
may
be
expected
as
a
result
of
livestock
ingesting
feedstuffs
derived
from
crops
which
may
be
treated
with
sethoxydim.
Permanent
tolerances
are
established
(
40
CFR
§
180.412)
for
residues
of
the
herbicide
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
in
meat
and
fat
of
cattle,
goats,
hogs,
horses,
poultry,
and
sheep
at
0.2
ppm;
meat
byproducts
of
cattle,
goats,
hogs,
horses,
and
sheep
at
1.0
ppm
(
2.0
ppm
in
meat
byproducts
of
poultry);
eggs
at
2.0
ppm,
and
milk
at
0.5
ppm.
The
existing
sethoxydim
permanent
tolerances
on
livestock
commodities
are
adequate
to
cover
the
maximum
potential
sethoxydim
residue
levels
presented
in
Tables
9
and
10.

860.1500
Crop
Field
Trials
In
the
Phase
IV
review
for
sethoxydim
(
L.
Cheng,
2/
25/
91),
HED
requested
magnitude
of
residue
studies
for
various
crops
to
fulfill
data
gaps
identified
during
review.
Subsequent
to
the
completion
of
the
Phase
IV
review,
the
validity
of
certain
field
studies
was
questioned
because
residue
samples
from
those
studies
had
been
analyzed
in
a
particular
contract
laboratory,
Craven
Labs
(
D165411,
L.
Cheng,
9/
23/
91).
As
a
result,
the
Agency
issued
a
DCI
to
replace
residue
chemistry
data
generated
by
Craven
Labs
for
alfalfa
hay,
artichoke,
succulent
beans,
dry
beans,
broccoli,
cabbage,
mustard
greens,
cotton,
flax,
peppers,
tomatoes,
grapes,
lentils,
peanuts,
succulent
peas,
dry
peas,
potatoes,
raspberry,
soybeans,
strawberry
and
sugar
beets.
Only
data
not
generated
by
Craven
Laboratories
are
included
in
the
following
summaries
of
crop
field
trials.

Alfalfa
Two
studies
were
originally
submitted
(
MRIDs
001155129
and
40515801)
to
provide
residue
chemistry
data
to
support
registration
of
sethoxydim
for
use
on
alfalfa.
As
some
of
the
alfalfa
hay
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
34
of
101
samples
were
analyzed
by
Craven
Laboratories,
HED
requested
replacement
data
reflecting
maximum
label
use
pattern
from
CA/
ID/
OR/
WA,
IA/
MN/
NE/
WI,
and
NY/
OH/
PA.
No
new
data
for
alfalfa
forage
were
requested
because
the
samples
were
not
analyzed
by
Craven
Labs
(
D165411,
L.
Cheng,
9/
23/
91).
In
response
to
the
data
request,
the
Registrant
submitted
another
study
(
MRID
41970901)
which
analyzed
both
alfalfa
hay
and
forage
samples.
The
new
forage
data,
however,
were
not
submitted
by
the
Registrant
with
the
intention
of
replacing
the
previously
submitted
data.
Summaries
of
the
submitted
data
are
provided
below.

Forage
MRIDs
00155129
and
40515801
(
D209952,
L.
Cheng,
1/
19/
95)

In
support
of
a
tolerance
of
40
ppm
on
alfalfa
forage
(
7­
day
PHI),
the
registrant
submitted
residue
data
in
MRID
00155129
(
submission
dated
12/
85)
and
40515801
(
6/
87).
HED
noted
that
residue
data
for
alfalfa
forage
had
not
been
generated
by
Craven,
so
no
replacement
data
were
needed
(
D165411,
L.
Cheng,
9/
23/
91).

According
to
a
memo
by
L.
Cheng
(
D209952,
1/
19/
95)
the
field
trials
described
in
MRID
00155129
were
conducted
in
CA,
AZ,
and
NM.
In
these
trials,
alfalfa
plants
were
treated
with
sethoxydim
at
1
x
0.5
lb
ai/
A
+
2
x
0.3
lb
ai/
A
or
3
x
0.5
lb
ai/
A
by
ground
application.
Information
on
spray
volumes
was
not
provided
in
the
report.
Forage
was
sampled
at
6
to
18
days
after
the
last
treatment.
Analytical
Method
30G
(
Determination
of
BAS
9052
H
and
Its
Metabolite
Residues
in
Alfalfa
Forage
and
Soybean
Forage)
was
used
for
residue
analysis
and
its
limit
of
quantitation
was
0.5
ppm
sethoxydim
equivalent
for
each
analyte.
Recoveries
were
73­
128%
for
MSO
(
parent
sulfoxide)
when
fortified
at
0.5,
1.0,
5.0,
10.0,
15.0,
20.0
or
30.0
ppm,
and
66­
112%
for
5­
OH­
MSO2
(
parent
sulfone
hydroxylated
at
C­
5
position)
when
fortified
at
the
same
levels.
Control
samples
contained
0.13
ppm
or
less
MSO
(<
0.5
ppm
sethoxydim)
or
5­
OHMSO2
equivalents.
Combined
residues
of
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
ranged
from
<
1.5
ppm
to
20.7
ppm.

The
study
described
in
MRID
40515801
was
a
side­
by­
side
aerial
versus
ground
application
experiment
conducted
in
CA
at
several
locations.
Identical
treatment
rates
and
virtually
identical
pre­
harvest
intervals
were
employed.
Plants
were
treated
with
sethoxydim
at
1
x
0.3
or
0.5
lb
ai/
A.
Samples
of
forage
were
collected
at
6­
10
days
and
20
or
22
days
later,
and
samples
of
hay
were
collected
19­
28
days
later.
Residue
levels
from
air
applications
(
1.7­
18.5
ppm
for
forage
and
3.8­
10.8
ppm
for
hay)
were
equal
or
less
than
those
from
ground
applications
(
1.6­
32.8
ppm
for
forage
and
4.1­
30.9
ppm
for
hay).
The
available
residue
data
are
adequate
to
support
the
current
tolerance
of
40
ppm
on
alfalfa
forage.

Hay
MRID
41970901
(
D200363,
L.
Cheng,
8/
22/
94)

In
D165411
(
L.
Cheng,
9/
23/
91),
HED
indicated
that
some
of
the
alfalfa
hay
residue
data
submitted
in
MRID
1155129
had
been
generated
by
Craven
Laboratories.
The
residue
data
not
generated
by
Craven
Laboratories
were
from
crop
field
trials
conducted
at
less
than
the
maximum
application
rate.
HED
requested
that
replacement
data
reflecting
maximum
label
use
pattern
from
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
35
of
101
CA/
ID/
OR/
WA,
IA/
MN/
NE/
WI,
and
NY/
OH/
PA
be
submitted
(
D165411,
L.
Cheng,
9/
23/
91).

In
response
to
the
Craven
DCI,
the
registrant
provided
residue
data
from
trials
conducted
in
CA,
IA,
ID,
KS,
MI,
MN,
ND,
NE,
NY,
SD,
and
WI.
These
data
were
also
provided
to
support
a
label
amendment
requesting
the
PHI
to
be
revised
to
14
days.
Alfalfa
received
three
applications
of
sethoxydim
at
0.5,
0.5
and
0.3
lb
ai/
A
at
intervals
varying
from
roughly
4
to
8
weeks.
Applications
were
made
by
ground
equipment
in
a
spray
volume
of
15­
20
gallons/
A.
Samples
of
forage
and
hay
were
collected
after
each
treatment
at
PHIs
of
12­
15
days;
one
cutting
had
a
PHI
of
7
days.
Forage
samples
were
frozen
immediately
after
harvest.
Forage
and
hay
samples
were
homogenized
and
stored
frozen
until
shipment
to
the
laboratory
for
analysis.

The
analytical
methods
used
were
modified
versions
of
Method
30G
(
for
alfalfa
and
soybean
forage)
and
Method
30H
(
for
alfalfa
and
soybean
hay).
The
limit
of
quantitation
was
0.5
ppm
for
DME
or
DME­
OH,
or
1.0
ppm
for
the
total
residue.
For
recoveries,
forage
and
hay
samples
were
fortified
with
metabolite
MSO
or
MSO2
at
0.5­
15.0
ppm
for
forage
and
at
0.5­
40
ppm
for
hay.
Better
individual
recoveries
were
obtained
in
forage
than
in
hay.
Average
recoveries
were
87
±
21%
(
N=
36)
for
forage
and
80
±
24%
(
N=
48)
for
hay.

Residue
samples
were
stored
for
ca
12­
18
months
before
analysis.
HED
concluded
that
data
submitted
for
corn
forage
and
dry
beans
were
adequate
to
show
the
stability
of
sethoxydim
residues
in
alfalfa
forage
and
hay
under
frozen
storage
conditions
for
27
months.

Residues
resulting
from
three
treatments
of
alfalfa
with
sethoxydim
at
0.5
+
0.5
+
0.3
lb
ai/
A
and
a
PHI
of
12­
15
days
ranged
up
to
15
ppm
in
forage
and
31
ppm
in
hay.
The
available
residue
data
are
adequate
to
support
the
current
tolerance
of
40
ppm
on
alfalfa
hay.

Almonds,
hulls
MRID
41428501
(
PP0F3855,
M.
J.
Nelson,
2/
7/
91)

Six
field
trials
were
conducted
in
CA
to
provide
residue
chemistry
data
to
support
registration
of
sethoxydim
for
use
on
almonds.
Multiple
applications
of
Poast
®
Herbicide
were
made
at
1x
or
2x
the
maximum
recommended
label
rate,
for
a
total
of
1.5
­
4
lb
ai/
A/
season.
PHIs
ranged
from
9
to
18
days.
Samples
were
harvested
at
normal
maturity
and
stored
frozen
for
up
to
48
months
prior
to
analysis
by
Method
30H.
Control
samples
(
almonds,
pecans
and
walnuts)
were
fortified
with
sethoxydim,
MSO
and
5­
OH­
MSO2
at
levels
ranging
from
0.1
ppm
to
1.5
ppm.
Recoveries
of
sethoxydim
ranged
from
68
to
120%
with
an
average
of
92%;
MSO
recoveries
ranged
from
72­
110%
with
an
average
of
89%;
while
for
5­
OH­
MSO2
recoveries
ranged
from
69
to
110%
with
an
average
of
83%.

Almonds
were
stored
for
24
months
(
4
field
trials),
35
months
(
1
field
trial),
and
48
months
(
1
field
trial).
The
registrant
referenced
storage
stability
data
from
other
crops
(
strawberries,
cherries,
soybeans,
peanut
hay,
and
succulent
peas)
that
indicated
stability
for
sethoxydim
and
its
metabolites
for
up
to
a
60­
month
storage
period.
HED
determined
that
only
the
data
for
soybean
seeds
were
not
generated
by
Craven,
and
these
data
only
support
storage
for
up
to
24
months
(
D198048,
L.
Cheng,
4/
26/
94).
However,
HED
concluded
that
the
stability
of
sethoxydim
and
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
36
of
101
metabolites
in
almonds
for
the
storage
duration
is
adequately
supported
by
the
Craven
replacement
storage
stability
data
that
shows
stability
in
various
frozen
commodities
for
3­
5
years
(
D256970,
N.
Dodd,
8/
9/
01).

Non­
detectable
residues
(<
0.1
ppm)
were
reported
for
DME­
OH
in
all
almond
hull
samples,
but
residues
of
DME
ranged
from
<
0.1
ppm
to
0.96
ppm.
The
available
residue
data
are
adequate
to
support
the
established
tolerance
level
of
2.0
ppm
for
almond,
hulls.

Apricot
MRID
41236404
(
PP9F3804/
PP9H5589,
S.
Inasi,
8/
8/
90)

Only
one
apricot
sample
was
analyzed;
the
total
residue
was
<
0.1
ppm.
HED
has
determined
that
the
residue
data
from
the
analysis
of
peaches
(
13
samples)
can
be
translated
to
apricots.
Residue
data
for
peaches
are
provided
under
the
Peaches
section
of
this
memo.

Artichoke,
globe
MRID
43973101
(
D238439,
W.
Cutchin,
4/
8/
98;
D225427,
W.
Cutchin,
6/
12/
98
The
original
artichoke
field
trial
data
submitted
were
generated
by
Craven
Laboratories.
The
data
were
replaced
with
two
globe
artichoke
field
trials
conducted
in
California
(
MRID
43973101).
Field
trial
residue
results
ranged
from
0.31
­
4.3
ppm.
These
data
support
the
established
tolerance
of
5.0
ppm
for
sethoxydim
on
globe
artichokes.
It
should
be
noted
that
the
tolerance
for
globe
artichoke
is
a
tolerance
with
regional
registration
listed
under
40
CFR
§
180.412
(
c).

Asparagus
MRID
42487401
&
42487402
(
D183351,
D.
Davis,
12/
4/
92)

Two
studies
were
submitted
(
MRID
42487401
and
42487402)
to
provide
residue
chemistry
data
to
support
registration
of
sethoxydim
for
use
on
asparagus.
MRID
42487401
provides
data
for
eight
field
trials
conducted
in
five
states
(
CA,
WA,
MI,
IL,
NJ)
and
MRID
42487402
provides
data
for
two
field
trials
conducted
in
two
states
(
MI
and
AZ).
HED
determined
that
the
number,
geographical
representation,
and
application
pattern
of
the
field
trials
are
adequate.
Additionally,
HED
determined
that
storage
stability
data
from
soybean
forage
and
succulent
legumes
studies
are
translatable
to
asparagus
and
are
adequate
to
demonstrate
the
stability
of
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
on
asparagus
for
the
interval
that
the
crop
field
residue
samples
were
stored.
The
results
indicate
maximum
combined
residues
of
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
are
2.14
ppm
for
MRID
42487401
and
3.5
ppm
for
MRID
42487402.
These
data
are
adequate
to
support
the
established
tolerance
level
of
4.0
ppm
for
sethoxydim
on
asparagus.

Bean,
dry,
seed
MRID
43801413
(
D237724,
L.
Cheng,
7/
28/
97)
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
37
of
101
Replacement
field
trials
to
replace
data
generated
by
Craven
Laboratories
on
dry
beans
were
conducted
in
CA(
2),
CO,
ID,
MI,
NE,
and
ND.
Beans
were
harvested
30
days
after
the
second
of
two
applications
of
the
1.5
lb/
gal
EC
formulation,
the
first
at
0.28
lb
ai/
A
and
the
second
14
days
later
at
0.47
lb
ai/
A
(
1x
the
maximum
registered
seasonal
rate).
Broadcast
applications
were
made
in
5
gal/
A
using
ground
equipment.

Samples
of
beans
were
bagged
and
stored
frozen
for
a
maximum
of
13
months
prior
to
analysis
using
GC/
FPD
Method
30.
HED
noted
that
storage
stability
data
on
13
matrices
submitted
with
the
residue
data
on
tomatoes,
broccoli,
mustard
greens,
and
cabbage
(
D219970,
4/
9/
96,
L.
Cheng)
indicate
that
sethoxydim
and
metabolites
are
stable
for
3­
5
years.
Thus,
adequate
supporting
storage
stability
data
are
available
to
cover
the
storage
intervals
reflected
in
the
field
trials.

Samples
were
analyzed
using
Method
30.
Concurrent
recoveries
were
adequate;
recoveries
ranged
from
68
to
95%
for
MSO
and
from
80
to
122%
for
5­
OH­
MSO2
in
dry
beans.
Apparent
combined
residues
were
less
than
the
limit
of
quantitation
(<
0.1
ppm)
in/
on
one
or
two
samples
of
untreated
dry
beans
from
each
trial.

HED
concluded
that
the
dry
bean
field
trials
were
acceptable.
The
trials
were
conducted
in
the
states
specified
by
the
DCI.
Residues
in
the
dry
beans
ranged
from
4.41
to
13.3
ppm.
These
data
are
adequate
to
support
the
established
tolerance
level
of
20.0
ppm
for
sethoxydim
on
bean,
dry,
seed.

Bean,
succulent
MRID
43801411(
D237724,
L.
Cheng,
7/
28/
97)

Studies
were
conducted
to
replace
existing
succulent
bean
residue
data
generated
by
Craven
Laboratories.
Field
trials
on
snap
beans
and
lima
beans
were
conducted
in
CA(
2),
FL,
MI,
NJ,
and
NC,
and
two
trials
on
cow
peas
were
conducted
in
FL
and
NC.
Bean
pods
were
harvested
15
days
after
the
second
of
two
applications
of
the
1.5
lb/
gal
EC
formulation,
the
first
at
0.28
lb
ai/
A
and
the
second
14
days
later
at
0.47
lb
ai/
A
(
1x
the
maximum
registered
seasonal
rate).
Broadcast
applications
were
made
in
5
gal/
A
using
ground
equipment.

Samples
of
bean
pods
were
bagged
and
stored
frozen
for
a
maximum
of
15
months
prior
to
analysis
using
GC/
FPD
method
30G.
As
noted
above,
adequate
supporting
storage
stability
data
were
available
to
cover
the
storage
intervals
reflected
in
the
field
trials.
Concurrent
recoveries
were
adequate.

Residues
were
detected
in
snap
bean
pods
at
0.52­
7.49
ppm,
in
lima
bean
pods
at
2.76­
5.08
ppm,
and
in
cow
pea
pods
at
2.41­
13.0
ppm.
HED
concluded
that
the
succulent
bean
field
trials
were
acceptable.
The
trials
were
conducted
in
the
states
specified
by
the
DCI.
These
data
indicate
that
the
established
tolerance
of
15
ppm
for
succulent
bean
is
adequate.

Bean,
forage
and
hay
MRID
43801413
and
43801411
(
D237724,
L.
Cheng,
7/
28/
97)
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
38
of
101
In
conjunction
with
field
trials
on
succulent
and
dry
beans,
the
registrant
provided
data
on
bean
vines
(
forage)
and
hay.
Vine
and
hay
samples
were
harvested
15­
30
days
following
two
applications
of
the
1.5
lb/
gal
EC
formulation
at
0.28
and
0.47
lb
ai/
A.
The
application
rates
and
PHIs
all
reflect
the
current
label
rates
for
these
crops.

Sethoxydim
residues
in
legume
forage
samples
were
analyzed
using
BASF
GC/
FPD
Methods
30G
and
30H,
following
up
to
15
months
in
frozen
storage.
As
noted
above,
adequate
supporting
storage
stability
data
were
available
to
cover
the
storage
intervals
reflected
in
the
field
trials.
Concurrent
recoveries
were
adequate.

Combined
residues
of
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
ranged
from
1
ppm
to
13
ppm
for
bean
forage
and
1
ppm
to
27
ppm
for
bean
hay.
HED
concluded
that
the
bean
foliage
field
trials
were
acceptable.
The
trials
were
conducted
in
the
states
specified
by
the
DCI.
These
data
indicate
that
the
established
tolerances
of
15
and
50
ppm
for
bean
forage
and
hay
are
adequate.

Beet,
Garden
No
MRID
number
(
D225427;
W.
Cutchin;
6/
12/
98)

No
data
on
garden
beets
were
submitted
by
the
Registrant.
HED
determined
that
since
sugar
beets
and
garden
beets
are
in
the
same
crop
subgroup,
data
can
be
translated
from
sugar
beets
to
garden
beets,
provided
the
PHI
is
increased
to
60
days.
As
the
registrant
has
complied
with
this
condition,
HED
concludes
that
the
established
tolerance
of
1.0
ppm
is
adequate
for
beet,
garden,
roots.

Beet,
sugar
(
roots
and
tops)
MRID
155129
and
MRID
40639101
(
Summary
in
MRID
92166067)
(
L.
Cheng,
2/
25/
91)
MRID
40639102
(
D185410
M.
I.
Rodríguez;
8/
25/
93)

According
to
the
Phase
IV
Review,
field
trials
(
MRID
155129
and
40639101)
were
conducted
in
major
sugar
beet
growing
areas
with
2
x
0.5
lb
ai/
A
(
label
maximum)
treatments
by
ground
and
aerial
equipment.
At
PHIs
approximating
100
days
(
the
previous
label
PHI),
roots
contained
<
0.1
ppm
residues
and
tops
contained
<
3
ppm
residues
(
L.
Cheng,
2/
25/
91).
It
was
determined
that
a
portion
of
the
sugar
beet
top
data
was
generated
by
Craven
Laboratories
(
D165411,
L.
Cheng,
9/
23/
91);
however,
the
data
for
the
sugar
beet
top
samples
collected
at
a
PHI
of
60
days
(
the
current
label
PHI)
were
not
analyzed
by
Craven
Laboratories
(
W.
Wassel;
8/
6/
93).
As
the
Registrant
submitted
an
amendment
to
decrease
the
pre­
harvest
interval
from
an
interval
of
100
days
to
an
interval
of
60
days,
no
further
sugarbeet
top
data
were
required.

The
non­
Craven
residue
data
for
sugar
beet
tops
reflecting
a
PHI
of
60
days
and
the
maximum
application
rate
of
1.0
lbs
ai/
A
(
two
applications
of
0.5
lbs
ai/
A,
both
ground
and
aerial
application
trials)
were
available
from
CA
(
10
trials),
ND
(
1
trial),
MN
(
1
trial),
ID
(
1
trial)
and
MT
(
1
trial).
In
these
field
trials,
the
highest
residue
level
was
approximately
0.73
ppm
with
preharvest
intervals
ranging
from
38
to
69
days.
The
established
tolerance
of
3.0
ppm
for
the
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
39
of
101
residues
of
sethoxydim
and
its
metabolites
in
or
on
sugar
beet
tops
is
adequately
supported
by
residue
data.

Since
the
Phase
IV
review,
the
registrant
also
submitted
an
amendment
to
increase
the
tolerance
for
sugar
beet
roots
from
0.1
to
1.0
ppm.
According
to
D185410
(
M.
I.
Rodríguez;
8/
25/
03),
two
sets
of
data
(
presumably
in
MRID
40639101
and
40639102)
were
available
to
support
these
changes.
In
one
set
of
data,
three
sugar
beet
root
samples
from
17
field
trials
in
9
states
were
over
the
limit
of
detection
(
0.05
ppm)
at
a
60
day
PHI.
These
residues
(
0.07,
0.20,
and
0.28
ppm)
were
detected
in
samples
which
received
two
applications
at
0.5
lb
ai/
A
application
(
total
of
1.0
lb
ai/
A).
The
other
set
of
data
(
14
trials
in
5
states)
show
that
the
maximum
level
detected
in
roots
was
0.40
ppm
at
a
60
day
PHI.
These
residues
were
detected
in
samples
which
also
received
two
applications
at
0.5
lb
ai/
A
application
(
total
of
1.0
lb
ai/
A).
The
established
tolerance
of
1.0
ppm
for
the
residues
of
sethoxydim
and
its
metabolites
in
or
on
sugar
beet
roots
is
adequately
supported
by
residue
data.

Blueberry
MRID
40492604
(
Summary
in
92166073)

Nine
field
trials
were
conducted
at
the
maximum
label
rate
and
minimum
PHI
in
the
following
states:
GA
(
Region
2),
IL
(
Region
5),
ME
(
Region
1),
MI
[
3
trials]
(
Region
5),
NC
(
Region
2),
NJ
(
Region
2),
and
WA
(
Region
12).
The
number
and
distribution
of
blueberry
field
trials
is
adequate
to
satisfy
reregistration
data
requirements.
Sethoxydim
was
applied
2
times
at
a
rate
of
0.5
lbs/
A/
application,
with
a
minimum
retreatment
interval
(
RTI)
of
9
days,
and
a
PHI
of
29­
33
days.
The
maximum
frozen
storage
interval
(<
­
5

C)
was
30
months.
This
interval
was
supported
by
strawberry
storage
stability
data
showing
no
significant
loss
of
residues
in
samples
held
at
<
­
5

C
for
up
to
31
months.
Fortification/
recovery
experiments
were
run
at
levels
ranging
from
0.05
to
15.0
ppm.
Control
blueberry
samples
were
fortified
with
sethoxydim
and/
or
metabolites
MSO
and
5­
OH­
MSO2
and
analyzed
concurrently
with
treated
samples,
using
Method
30G.
Recoveries
ranged
from
82­
126%.
Residue
levels
in
treated
blueberry
samples
ranged
from
<
0.10
­
3.4
ppm.
These
values
adequately
support
the
established
blueberry
tolerance
level
of
4.0
ppm.

Caneberry
subgroup
13A
MRID
00157187
(
Summary
in
92166066)
(
L.
Cheng,
2/
25/
91)
MRID
43972701
(
D238439,
W.
Cutchin,
4/
8/
98;
D225427,
W.
Cutchin,
6/
12/
98)

Crop
field
trials
were
submitted
for
raspberries,
a
representative
commodity
of
the
caneberry
subgroup.
The
trials
were
conducted
in
MI,
OR,
WA,
CA,
NJ,
and
NY
(
MRID
00157187)
Sethoxydim
was
applied
2
or
3
times
at
a
rate
of
0.5
lb
ai/
A/
application.
The
samples
from
MI,
OR,
WA,
and
CA
were
collected
at
a
PHI
of
45
days
and
the
samples
from
NJ
and
NY
were
collected
at
a
PHI
of
21
to
31
days.
The
Phase
IV
review
indicates
that
all
residue
values
were
below
the
established
tolerance
of
5
ppm.
In
D165411
(
L.
Cheng,
9/
23/
91),
HED
noted
that
even
though
the
tolerance
was
set
at
5
ppm,
the
residues
resulting
from
2
x
0.5
lb
ai/
A
and
a
PHI
of
45
days
were
generally
<
0.1
ppm.
It
was
determined
that
Craven
Laboratory
analyzed
the
samples
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
40
of
101
from
the
MI,
OR,
WA,
and
CA
test
sites
(
D165411,
L.
Cheng,
9/
23/
91).
HED
concluded
that
the
NJ
and
NY
data
were
adequate
to
support
the
raspberry
tolerance
in
the
interim;
however,
raspberry
residue
data
from
WA
and
OR
may
be
required
to
support
the
established
tolerance.

To
replace
the
Craven
data,
two
trials
(
OR
and
WA)
on
raspberries
conducted
in
1996
were
submitted
(
MRID
43972701).
In
the
OR
study,
sethoxydim
was
applied
twice
at
approximately
0.5
lb
ai/
A
and
samples
taken
at
a
45­
day
PHI.
In
the
WA
study,
sethoxydim
was
applied
twice
at
approximately
1.0
lb
ai/
A
(
2x
the
maximum
label
rate)
and
samples
taken
at
a
39­
day
PHI.

The
raspberry
samples
from
MRID
43972701
were
analyzed
using
BASF
Method
30.
Recoveries
from
samples
fortified
with
DME
and
DME­
OH
at
0.042
to
0.86
ppm
and
concurrently
analyzed
with
the
field
samples
ranged
from
85­
122%
(
n
=
20).
The
highest
sethoxydim
residue
found
was
from
a
sample
from
the
WA
study
which
contained
4.3
ppm
total
residues
as
sethoxydim.
The
performing
laboratory,
Analytical
Labs.,
Dept.
of
Food
Science,
Cornell
University,
included
sample
chromatograms
and
calibration
curves
(
D238439;
W.
Cutchin;
4/
8/
98).
These
data
are
adequate
to
support
the
established
sethoxydim
tolerance
level
of
5.0
ppm
for
crop
subgroup
13A
(
caneberries).

Canola,
rapeseed
MRID
42074201
(
D171714,
D171716,
D171724,
B.
Schneider,
9/
21/
92)
Eight
field
trials
were
conducted
in
the
following
six
states:
ID,
MT,
ND,
OH,
OR,
and
TN.
It
was
noted
that
these
states
represent
>
60
%
of
the
total
U.
S.
canola
production
(
D171714,
D171716,
D171724,
B.
A.
Schneider,
6/
4/
92).
HED
concluded
that
geographical
representation
for
the
submitted
field
trials
for
canola
is
adequate.
Sethoxydim
(
Poast
®
Herbicide)
was
applied
postemergent
at
two
applications
at
14­
19
day
intervals
using
the
maximum
label
rate
at
0.5
lb
ai/
A
(
1X)
with
PHI's
ranging
from
59­
61
days.
These
treatments
were
applied
as
a
broadcast
ground
application
directly
to
the
emerged
weeds
(
4­
6
inches
tall).

Samples
of
the
forage
and
seed
were
stored
frozen
at
<
­
5

C
until
further
analysis;
samples
were
analyzed
19
months
after
initial
storage
following
harvest.
No
storage
stability
data
were
submitted
for
this
crop;
however,
HED
concluded
that
storage
stability
data
developed
for
soybean
seed
were
adequate
and
translatable
to
canola.

Slight
modifications
of
the
BASF
Method
30
and
BASF
Method
30G
were
used
for
the
determination
of
sethoxydim
in
canola
seeds
and
forage,
respectively.
No
samples
were
analyzed
by
the
Craven
Laboratories.
The
limit
of
quantitation
was
0.05
ppm
of
sethoxydim
equivalents
for
DME
or
DME­
OH,
or
1.0
ppm
for
the
total
residue.
Control
samples
were
fortified
with
the
metabolite
MSO
and
5­
OH­
MSO2.
The
canola
forage
samples
showed
recoveries
of
MSO
ranging
from
61
to
115%
with
an
average
of
91
±
12%;
while
for
5­
OH­
MSO2
ranged
from
65
to
114%
with
an
average
of
96
±
13%.
The
canola
seed
samples
showed
recoveries
of
MSO
ranging
from
69
to
115%
with
an
average
of
94
±
14.5%;
while
for
5­
OH­
MSO2
ranged
from
59
to
125%
with
an
average
of
100
±
14.7%.

At
an
application
rate
of
0.5
lb
ai/
A
and
a
PHI
of
59­
61
days,
total
sethoxydim
residue
(
calculated
as
sum
of
DME
plus
DME­
OH)
in
canola
forage
ranged
from
<
1.0­
3.5
ppm
while
the
residues
in
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
41
of
101
canola
seed
ranged
from
3.7­
35.0
ppm.
These
data
are
adequate
to
support
the
established
sethoxydim
tolerance
level
of
35.0
ppm
for
canola
seed.
However,
the
preferred
commodity
definition
for
this
RAC
is
"
Rapeseed,
seed".

Carrot,
roots
MRID
42195001
(
D174374,
M.
I.
Rodriguez,
8/
7/
92;
D185410,
M.
I.
Rodriguez,
8/
25/
93)

Field
studies
were
conducted
in
CA,
TX,
MI,
WA,
NY,
FL,
WI
and
NJ.
In
all
the
studies,
two
applications
were
made
at
0.5
lb
ai/
A.
The
first
application
was
made
approximately
2
to
3
weeks
after
carrot
leaf
emergence
and
the
second
application
was
made
within
21
to
28
days
of
harvest.
All
sprays
included
crop
oil
concentrate.

Carrot
root
samples
were
harvested
and
then
frozen
at
less
than
­
10
°
C
until
homogenized
into
ground
carrot
pulp.
After
processing,
the
samples
were
frozen
again
until
analysis.
Samples
were
stored
for
12
months
prior
to
analysis.
No
storage
stability
data
were
provided
in
this
study;
however,
HED
concluded
that
storage
stability
data
developed
for
sugar
beets
adequately
covered
the
storage
interval
used
for
carrot
samples.

Method
30
G,
with
modifications
(
use
of
C18
cleanup
column
if
interfering
peaks
were
present)
was
used
for
analysis
of
carrot
samples.
Recoveries
for
samples
fortified
with
sethoxydim,
MSO
and
5­
OH­
MSO2
at
levels
ranging
from
0.05
ppm
to
0.7
ppm
were
95­
116%
for
DME
and
83­
121%
for
DME­
OH.
The
results
of
the
residue
analysis
indicated
that
the
maximum
residue
recovered
in
treated
carrots
was
0.72
ppm
(
PHI
=
25
days).

In
the
8/
7/
92
review,
HED
requested
additional
field
trials
on
carrots.
However,
HED
later
determined
that
sethoxydim
data
for
carrots
show
similarity
to
data
obtained
for
other
crops
(
sugar
beets,
sweet
potatoes,
bulb
vegetables,
and
root/
tuber
crops)
and
thus,
the
data
submitted
are
adequate
(
D185410,
M.
I.
Rodriguez,
8/
25/
93).
Accordingly,
the
available
data
are
adequate
to
support
the
established
tolerance
level
of
1.0
ppm
for
"
carrot,
roots".

Cherry
(
sweet
and
tart)
MRID
41236401
(
PP9F3804/
PP9H5589,
S.
Inasi,
8/
8/
90)

A
total
of
12
field
trials
were
conducted
in
5
states
for
sour
cherries
and
in
4
states
for
sweet
cherries.
Application
rates
ranged
from
0.8
lb
ai/
A
(
0.8X)
to
1.5
lb
ai/
A
(
1.5
X)
and
PHIs
ranged
from
7
to
43
days.
Samples
were
stored
frozen
for
28
to
45
months.
The
storage
stability
data
submitted
as
a
response
to
the
Craven
DCI
show
that
MSO
and
5­
OH­
MSO2
are
stable
in
cherries
for
5
and
3
years,
respectively.

Method
30
G
was
used
for
analysis.
Samples
of
stone
fruits
were
fortified
with
0.05,
0.5
and
1.0
ppm
of
sethoxydim,
MSO
and
5­
OH­
MSO2;
recovery
for
residues
of
sethoxydim
and
its
metabolites
in/
on
sweet
and
sour
cherries
and
peaches
ranged
from
74­
108
percent
at
all
three
levels.

At
a
PHI
range
of
7
to
43
days
the
total
residues
of
DME
and
5­
OH­
DME
observed
in
7
samples
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
42
of
101
of
each
fruit
were
<
0.13
ppm.
The
available
data
are
adequate
to
support
the
current
tolerance
level
of
0.2
ppm
for
cherry,
sweet
and
cherry,
sour.

Clover
Hay
and
Forage
MRID
42353601
(
D179955
&
D179957,
M.
I.
Rodriguez,
9/
16/
93)

Thirteen
crop
field
trials
were
conducted
in
the
states
of
OR,
ID,
MN,
NB,
TN,
NY,
MO,
CA,
and
TX.
Each
trial
consisted
of
two
treated
plots
(
one
designated
to
produce
forage
and
another
one
to
produce
hay)
and
two
untreated
control
plots
(
one
for
forage
and
one
for
hay).
Each
of
the
treated
plots
was
subdivided
into
three
equal
replicate
plots.
Poast
®
Herbicide
was
applied
at
rates
of
0.5,
0.5,
and
0.3
lb
ai/
A
before
the
first,
second,
and
third
cuttings,
respectively.
For
all
trials,
three
cuttings
during
a
single
season
were
performed.
Poast
®
Herbicide
was
applied
at
preharvest
intervals
of
20­
21
days
for
clover
hay,
and
6­
7
days
for
clover
forage.
At
each
site,
the
plot
designated
to
produce
forage
was
treated
13
days
after
the
plot
designated
to
produce
hay
in
order
that
both
could
be
harvested
on
the
same
day
for
each
cutting.
The
general
sequence
was
herbicide
application,
cutting,
application,
cutting,
and
final
application
and
cutting.
The
clover
hay
plots
were
cut
as
forage
20­
21
days
after
each
Poast
®
application
and
allowed
to
dry
in
the
field
for
2­
8
days
to
produce
hay.
Hay
samples
were
then
collected
and
frozen.
Clover
forage
was
harvested
6­
7
days
after
each
Poast
®
application.

The
clover
forage
and
hay
samples
were
stored
at
less
than
­
5
oC
until
analyzed.
A
maximum
of
24
months
elapsed
between
harvest
and
analysis
of
samples.
Storage
stability
data
were
not
submitted
with
this
study.
HED
concluded
that
data
generated
for
corn
forage
adequately
covers
the
use
in/
on
clover
forage.
The
storage
stability
data
for
alfalfa
hay
does
not
cover
the
storage
duration
of
the
clover
hay,
therefore,
these
data
can
not
be
translated.
However,
as
the
stability
of
sethoxydim
under
similar
conditions
has
been
demonstrated
with
numerous
other
crops
(
sugar
beet,
potato,
head
lettuce,
beans,
snap,
peanut,
hay,
beans,
succulent,
peas,
succulent,
and
soybeans,
forage),
HED
concluded
these
data
are
acceptable
for
translation
and
that
no
storage
stability
data
are
required
for
clover
hay.

Methods
30
G
and
30H
were
used
for
analysis
of
forage
and
hay
samples,
respectively.
Mean
method
recoveries
were
97
±
12%
(
N=
52)
for
clover
forage
and
96
±
17%
(
N=
60)
for
clover
hay.
Control
samples
were
fortified
with
MSO
and
5­
OH­
MSO2.
Fortifications
ranged
from
0.5
ppm
to
30
ppm
(
per
metabolite)
for
clover
forage
and
0.5
ppm
to
50
ppm
(
per
metabolite)
for
clover
hay.

The
clover
hay
samples
showed
a
maximum
sethoxydim
residue
level
of
50.7
ppm
(
sample
in
OR,
first
cutting).
Samples
from
other
sites
and
cuttings
had
residue
levels
ranging
from
3.3
ppm
to
48
ppm.
The
mean
total
sethoxydim
residue
was
19.3
ppm.
Replicate
samples
at
the
site
with
the
highest
residue
contained
5.4/
5.9
ppm
(
duplicate
analyses),
48.3/
50.7
ppm
(
duplicate
analyses),
and
49.8
ppm
total
residues.

The
clover
forage
samples
showed
a
maximum
sethoxydim
residue
level
of
30.9
ppm
(
sample
at
another
site
in
OR,
third
cutting).
Samples
from
other
sites
and
cuttings
had
residue
levels
ranging
from
1.9
ppm
to
30.6
ppm.
The
mean
total
sethoxydim
residue
was
14.8
ppm.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
43
of
101
The
maximum
residue
detected
in
the
clover
hay
samples
was
50.7
ppm,
which
is
slightly
more
than
the
tolerance
level
of
50
ppm.
Thus,
the
established
tolerance
level
for
clover
hay
should
be
increased
to
55
ppm,
while
the
established
tolerance
level
of
35
ppm
is
adequate
for
clover
forage.

Coriander
(
D238439,
W.
D.
Cutchin
and
M.
J.
Nelson,
4/
8/
98)

Although
no
residue
data
were
submitted
for
coriander,
HED
recommended
a
tolerance
level
of
4.0
ppm
for
this
commodity
for
the
following
reasons:
1)
there
exists
a
tolerance
of
4.0
ppm
for
the
leafy
vegetables
(
except
Brassica)
crop
group
#
4,
2)
parsley
is
a
member
of
crop
group
#
4,
and
3)
a
commodity
definition
has
been
established
allowing
translation
of
parsley,
leaves
data
to
cover
cilantro
(
coriander)
[
Reviewer's
Guide,
B.
A.
Schneider,
6/
14/
02].

Corn
In
PP#
9F3806,
the
registrant
submitted
residue
data
(
MRID
41248401,
41248402,
41248403,
and
41248404)
to
support
a
proposed
label
for
Poast
®
Herbicide
involving
directed
spray
application
to
the
base
of
the
corn
plant
to
control
annual
grasses
in
field
and
sweet
corn
(
30­
day
PHI)
and
proposed
tolerances
for
field
corn
grain
(
0.1
ppm),
sweet
corn
(
0.2
ppm),
corn
forage
(
0.2
ppm)
and
corn
fodder
(
0.2
ppm).
These
data
were
deemed
adequate
by
HED
(
PP#
9F3806,
M.
I.
Rodriguez,
2/
27/
90).
However,
in
PP4F04344
and
PP#
2F04075,
the
registrant
proposed
to
amend
the
registration
to
use
Poast
®
in
an
over­
the­
top
application
to
sethoxydim­
resistant
(
SR)
field
corn
and
sweet
corn
and
to
increase
the
application
rate
for
the
control
of
grassy
weeds.
Residue
data
submitted
in
support
of
PP4F04344
and
PP#
2F04075
are
summarized
below.

Field
Corn
MRIDs
43178701
and
43455701
(
D210060,
D210062,
D208310,
&
D208312,
M.
I.
Rodriguez,
7/
24/
95)

Two
residue
studies
were
submitted
for
review.
In
each
study,
trials
were
performed
at
the
rate
of
0.2
lb
ai/
acre
and
at
rate
of
0.6
lb
ai/
acre
(
2
applications
of
0.3
lb
ai/
acre
each).
In
both
cases,
trials
were
performed
across
the
United
States
and
Canada.
Poast
®
was
applied
post­
emergent
at
the
3­
to
5­
leaf
stage
over­
the­
top
of
the
corn
using
ground
application
equipment.
For
the
proposed
increased
rate,
a
second
Poast
®
application
was
made
30
days
later.

All
samples
were
frozen
at
­
5
oC
immediately
after
harvest
and
maintained
frozen
until
analysis.
A
maximum
of
9
months
lapsed
between
harvest
and
analysis
of
the
samples.
No
concurrent
storage
stability
data
were
included
in
the
submission.
However,
HED
had
previously
determined
that
two
sethoxydim
metabolites
(
MSO
and
5­
OH­
MSO2)
are
stable
under
freezer
storage
conditions
for
5
years
in
corn
grain
and
corn
forage
(
D219970,
L.
Cheng,
4/
9/
96),
and
residues
of
parent,
MSO2,
M2SO2,
and
5­
OH­
MSO2
(
each
separately
spiked
and
analyzed)
were
stable
in
soybeans
under
frozen
storage
for
18
and
24
months
(
D198048,
L.
Cheng,
4/
26/
94).
Analytical
Method
A9003
was
used
for
analysis.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
44
of
101
For
the
lower
application
rate,
a
total
of
25
trials
were
performed.
PHIs
ranged
from
59­
90
days,
from
75­
106
days,
and
from
90­
147
days
for
forage,
silage,
and
fodder/
grain,
respectively.
Residues
ranged
from
<
0.1
­
0.17
ppm,
<
0.1
­
0.48
ppm,
<
0.1
­
0.20
ppm,
and
were
<
0.1
ppm
for
forage,
silage,
fodder,
and
grain,
respectively.

For
the
higher
application
rate,
a
total
of
24
trials
was
performed.
PHIs
ranged
from
29­
60
days,
from
45­
76
days,
and
from
60­
117
days
for
forage,
silage,
and
fodder/
grain,
respectively.
Residues
ranged
from
<
0.10
­
1.52
ppm,
<
0.10
­
1.62
ppm,
<
0.10
­
2.11
ppm,
and
<
0.10
­
0.40
ppm
for
forage,
silage,
fodder,
and
grain,
respectively.

The
available
data
are
adequate
to
support
the
current
tolerance
levels
of
2.0,
3.5,
and
0.5
ppm
for
field
corn
forage,
fodder,
and
grain,
respectively.

Sweet
Corn
MRID
45100501
(
D266208/
D266210,
N.
Dodd,
7/
5/
02)

A
total
of
14
trials
were
conducted
in
CA,
FL,
IA,
IL,
IN,
MI,
NC,
NJ,
OR,
PA,
WA,
and
WI
during
the
1997
growing
season.
In
each
test
location,
sethoxydim­
resistant
hybrids
of
sweet
corn
received
two
applications
with
a
10­
day
retreatment
interval
of
the
proposed
formulation,
a
1.5
lb
ai/
gal
EC.
Each
application
was
made
as
an
over­
the­
top
postemergence
treatment
at
a
nominal
rate
of
0.3
lb
ai/
A
per
application
for
a
total
of
0.6
lb
ai/
A
(
1.0x
the
maximum
proposed
seasonal
rate
for
sweet
corn).

Sweet
corn
RAC
samples
were
collected
at
normal
crop
maturity
and
then
frozen
prior
to
residue
analysis.
Fresh
sweet
corn
(
kernels
plus
cob
with
husk
removed)
and
forage
were
collected
30
days
after
the
second
treatment.
Stover
was
collected
according
to
normal
practices,
and
led
to
harvest
from
33
to
85
days
after
the
second
treatment.
Samples
were
kept
in
a
freezer
for
up
to
7.5
to
10.5
months
prior
to
analysis.
No
concurrent
storage
stability
data
were
included
in
the
submission.
However,
HED
had
previously
determined
that
two
sethoxydim
metabolites
(
MSO
and
5­
OH­
MSO2)
are
stable
under
freezer
storage
conditions
for
5
years
in
corn
grain
and
corn
forage
(
D219970,
L.
Cheng,
4/
9/
96),
and
residues
of
parent,
MSO2,
M2SO2,
and
5­
OH­
MSO2
(
each
separately
spiked
and
analyzed)
were
stable
in
soybeans
under
frozen
storage
for
18
and
24
months
(
D198048,
L.
Cheng,
4/
26/
94).

Fresh
corn,
forage,
and
stover
were
analyzed
by
BASF
Analytical
Methods
A9003,
30G,
and
30H,
respectively.
Concurrent
method
recoveries
indicated
these
methods
were
adequate
for
data
collection.
Average
recoveries
were
92,
99,
and
101%
for
MSO
in
sweet
corn,
forage
and
stover,
respectively.
Average
recoveries
were
81,
91
and
88%
for
5­
OH­
MSO2
in
sweet
corn,
forage
and
stover,
respectively.

Following
analysis
of
1.0x­
treated
samples
that
were
collected
at
the
proposed
30­
day
PHI,
the
combined
residues
of
DME
and
DME­
OH
(
calculated
as
total
sethoxydim)
were
<
0.10­<
0.34
ppm
in/
on
sweet
corn
grain
and
<
0.38­<
2.67
ppm
in/
on
sweet
corn
forage.
The
combined
residues
in/
on
treated
samples
of
sweet
corn
stover,
collected
at
33­
85
day
PHI,
were
<
0.16­
<
3.32
ppm.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
45
of
101
The
residue
decline
data
showed
trends
of
lower
residues
with
longer
PHIs
in/
on
sweet
corn
grain
and
forage.
There
was
no
decline
trend
for
stover
as
residues
remained
consistent
through
the
71­
to
91­
day
sampling
intervals.
The
available
data
are
adequate
to
support
the
current
tolerance
levels
of
0.4,
3.0,
and
3.5
ppm
for
sweet
corn
grain,
forage,
and
stover,
respectively.

Cotton,
undelinted
seed
MRID
43062205
(
D198048,
L.
Cheng,
4/
26/
94)

Field
trials
were
conducted
in
CA,
GA,
MS,
and
TX.
Three
applications
were
made
at
0.43­
0.48
lb
ai/
A/
application
at
21­
day
intervals
approximating
the
3
x
0.47
lb
ai/
A
label
rate.
Harvests
were
made
at
40
or
42
days
after
the
last
application.
Cotton
was
mechanically
ginned
immediately.
Cottonseeds
with
lint
were
frozen
after
harvest
and
shipped.

Samples
were
stored
for
up
to
5
months
before
residue
analyses.
HED
noted
that
storage
stability
data
previously
generated
from
soybean
seeds
indicated
stability
of
sethoxydim
metabolites
during
this
period.
The
stability
data
were
not
generated
by
Craven
labs.

Residue
samples
were
analyzed
by
BASF
Method
30A.
Recoveries
from
fortified
control
sample
were
adequate.
Average
recoveries
in
cottonseeds
were
76.0
±
10.7%
for
MSO
and
77.9
±
2.5%
for
5­
OH­
MSO2.

Residues
in
cottonseeds
resulting
from
treatment
of
cotton
with
sethoxydim
ranged
from
0.66
to
4.01
ppm.
The
available
data
are
adequate
to
support
the
current
tolerance
level
of
5.0
ppm
for
cotton,
undelinted
seed.

Cranberry
MRID
41627001
(
PP0E3909,
M.
J.
Nelson,
2/
14/
91)

Five
trials
were
conducted
in
WI
(
2),
MA
(
1),
and
WA
(
2).
One
to
three
applications
at
0.5
to
2.0
lbs
ai/
A
were
applied
to
cranberries.
PHIs
of
31
to
110
were
utilized.

Samples
were
harvested
at
normal
maturity
and
stored
frozen
5­
29
months
prior
to
analysis
by
Method
30G.
Control
samples
were
fortified
with
sethoxydim,
MSO
and
5­
OH­
MSO2
at
levels
ranging
from
0.05
to
5
ppm.
Average
recoveries
were
93,
88,
and
96%
for
sethoxydim,
MSO
and
5­
OH­
MSO2,
respectively.

Storage
stability
data
were
not
submitted
for
cranberries.
The
registrant
referenced
data
from
other
crops
(
strawberries,
cherries,
soybeans,
peanut
hay,
and
succulent
peas)
that
indicated
storage
stability
for
sethoxydim
and
its
metabolites
for
up
to
a
60­
month
period;
however,
these
data,
except
for
soybeans,
were
generated
by
Craven
Laboratories
(
D165411,
L.
Cheng,
9/
23/
91).
Field
trials
conducted
to
replace
the
Craven
generated
data
show
that
sethoxydim
and
it's
metabolites
are
stable
in
13
different
matrices
(
including
strawberries
and
cherries)
for
3
to
5
years.
These
data
are
translatable
to
cranberries.

Overall,
total
residue
of
sethoxydim
ranged
from
0.25
to
5.0
ppm.
At
an
application
rate
of
1.0
lb
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
46
of
101
ai/
A
(
1x
maximum
rate)
and
a
PHI
of
60
days,
residues
were
1.2
ppm
and
2.20
ppm
(
1
sample).

For
the
current
use
pattern,
the
maximum
residue
found
(
2.2
ppm)
is
greater
than
the
tolerance
of
2
ppm.
Therefore,
the
sethoxydim
tolerance
level
for
cranberries
should
be
increased
to
2.5
ppm.

Flax,
seed
and
straw
MRID
43801409
(
D237724,
L.
Cheng,
7/
28/
97)

Studies
were
conducted
to
replace
flax
residue
data
generated
by
Craven
Laboratories.
Three
field
trials
on
flax
were
conducted
in
MN,
ND,
and
SD.
Flaxseed
and
straw
were
harvested
75
days
after
three
applications
of
the
1.5
lb/
gal
EC,
each
at
0.19
lb
ai/
A
(
1x
the
maximum
registered
rate).
Broadcast
applications
were
made
in
5
gal/
A
using
ground
equipment.

Samples
were
bagged
and
frozen
(
temperature
unspecified)
within
2.5
hours
of
collection
and
were
stored
frozen
for
a
maximum
of
10
months.
HED
noted
that
storage
stability
data
on
13
matrices
submitted
with
the
residue
data
on
tomatoes,
broccoli,
mustard
greens,
and
cabbage
(
D219970,
4/
9/
96,
L.
Cheng)
indicate
that
sethoxydim
and
metabolites
are
stable
for
3­
5
years.
Thus,
adequate
supporting
storage
stability
data
were
available
to
cover
the
storage
intervals
reflected
in
the
field
trials.

Samples
were
analyzed
using
GC/
FPD
Methods
30
(
seed)
and
30H
(
straw).
Concurrent
recoveries
were
adequate;
for
flax
seed
recoveries
were
69.5%
and
71.5%
for
MSO
and
94.6%
and
76.8%
for
5­
OH­
MSO2;
for
flax
straw
recoveries
were
100%
and
69.5%
for
MSO
and
107%
and
83.2%
for
5­
OH­
MSO2.

At
a
total
application
rate
of
0.57
lb
ai/
A
and
a
PHI
of
75
days,
combined
residues
of
sethoxydim
were
0.49­
0.86
ppm
in
flax
seed
and
0.25­
0.43
ppm
in
flax
straw.
Because
flax
straw
is
not
considered
a
significant
livestock
feed
item
(
see
Table
1,
Series
860
OPPTS
Test
Guidelines)
the
tolerance
for
flax
straw
should
be
revoked.
For
flax,
the
maximum
rate
per
application
is
0.28
lb
ai/
A,
with
a
total
maximum
per
season
of
0.75
lb
ai/
A.
Accordingly,
the
field
trial
data
reflects
a
use
rate
of
approximately
0.76x.
To
account
for
the
higher
rate
on
the
label,
the
established
tolerance
level
of
5.0
ppm
for
flax,
seed
is
appropriate.

Fruit,
Citrus,
Group
10
MRIDs
40492601,
40492602
and
40492603
(
Summary
in
92166069)

Field
trials
were
conducted
on
oranges,
lemons,
and
grapefruit
to
establish
a
tolerance
for
the
citrus
fruits
crop
group.
Trials
were
conducted
in
FL,
CA,
and
TX
for
oranges
and
grapefruit;
and
in
AZ
and
CA
for
lemons.
The
number
and
distribution
of
field
trials
is
adequate
to
satisfy
reregistration
data
requirements.
The
maximum
frozen
storage
interval
(<
­
5

C)
was
50
months.
This
interval
was
supported
by
storage
stability
data
on
oranges,
strawberries,
and
succulent
peas,
which
showed
no
significant
loss
of
residues
in
samples
held
at
<
­
5

C
for
up
to
31,
60,
and
52
months,
respectively.
Fortification/
recovery
experiments
were
run
at
levels
ranging
from
0.05
to
5.0
ppm,
and
showed
recoveries
ranging
from
68­
112%
for
all
three
representative
crops.
Control
samples
were
fortified
with
sethoxydim
and/
or
metabolites
MSO
and
5­
OH­
MSO2
and
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
47
of
101
analyzed
concurrently
with
treated
samples,
using
Method
30G.
The
available
data
are
adequate
to
support
the
current
tolerance
level
of
0.5
ppm
for
crop
group
10.

Oranges
Sethoxydim
was
applied
4­
5
times
at
a
rate
of
0.5
lbs/
A/
application,
with
a
minimum
retreatment
interval
(
RTI)
of
20
days,
and
a
PHI
of
3­
15
days.
Exaggerated
rate
studies
consisted
of
5­
6
applications
at
1.0
or
2.0
lbs/
A/
application.
The
maximum
combined
residue
level
at
a
1x
treatment
rate
was
0.30
ppm;
the
maximum
combined
residue
level
at
a
2x
treatment
rate
was
0.35
ppm.

Lemons
Sethoxydim
was
applied
4­
6
times
at
a
rate
of
0.5
lbs/
A/
application,
with
a
minimum
retreatment
interval
(
RTI)
of
20
days,
and
a
PHI
of
3­
15
days.
Exaggerated
rate
studies
consisted
of
3­
6
applications
at
1.0
lb/
A/
application.
The
maximum
combined
residue
level
at
a1x
treatment
rate
was
<
0.10
ppm;
the
maximum
combined
residue
level
at
a
2x
treatment
rate
was
0.37
ppm.

Grapefruit
Sethoxydim
was
applied
4­
5
times
at
a
rate
of
0.5
lbs/
A/
application,
with
a
minimum
retreatment
interval
(
RTI)
of
20
days,
and
a
PHI
of
3­
15
days.
Exaggerated
rate
studies
consisted
of
4­
5
applications
at
1.0
lbs/
A/
application.
The
maximum
combined
residue
level
at
a1x
treatment
rate
was
0.27
ppm;
the
maximum
combined
residue
level
at
a
2x
treatment
rate
was
0.46
ppm.

Fruit,
Pome,
Group
11
MRIDs
40576101
and
40576102
(
Summary
in
92166070)

Field
trials
were
conducted
on
apples
(
13)
and
pears
(
6)
to
establish
a
tolerance
for
the
pome
fruits
crop
group.
Trials
were
conducted
in
CA,
CT,
NY,
MI,
PA,
OR,
and
WA
for
apples;
and
in
CA,
MI,
PA,
OR,
and
WA
for
pears.
The
number
and
distribution
of
field
trials
is
adequate
to
satisfy
reregistration
data
requirements.
The
maximum
frozen
storage
interval
(<
­
5

C)
was
38
months.
This
interval
was
supported
by
storage
stability
data
on
apples
and
strawberries,
which
showed
no
significant
loss
of
residues
in
samples
held
at
<
­
5

C
for
up
to
37
and
60
months,
respectively.
Fortification/
recovery
experiments
were
run
at
levels
ranging
from
0.05
to
1.0
ppm,
and
showed
recoveries
ranging
from
64­
108%
for
the
two
representative
crops.
Control
samples
were
fortified
with
sethoxydim
and/
or
metabolites
MSO
and
5­
OH­
MSO2
and
analyzed
concurrently
with
treated
samples,
using
Method
30G.
The
available
data
are
adequate
to
support
the
current
tolerance
level
of
0.2
ppm
for
crop
group
11.

Apples
Sethoxydim
was
applied
3­
5
times
at
a
rate
of
0.5
lbs/
A/
application
(
1x),
with
a
minimum
retreatment
interval
(
RTI)
of
11
days,
and
a
PHI
of
7­
15
days.
Exaggerated
rate
studies
consisted
of
4
applications
at
2.0
lbs/
A/
application
(
4x).
The
maximum
combined
residue
levels
at
treatment
rates
of
1x
and
4x
was
0.15
ppm.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
48
of
101
Pears
Sethoxydim
was
applied
3­
5
times
at
a
rate
of
0.5
lbs/
A/
application,
with
a
minimum
retreatment
interval
(
RTI)
of
25
days,
and
a
PHI
of
10­
17
days.
The
maximum
combined
residue
level
at
a
1x
treatment
rate
was
<
0.10
ppm.

Grapes
MRID
43801410
(
D237724,
L.
Cheng,
7/
28/
97)

Studies
were
conducted
to
replace
existing
grape
residue
data
generated
by
Craven
Laboratories.
Six
field
trials
on
grapes
were
conducted
in
CA(
2),
MI,
NY,
NC,
and
WA.
Grapes
were
harvested
50
days
after
two
applications
of
the
1.5
lb/
gal
EC,
each
at
0.47
lb
ai/
A
(
1x
the
maximum
registered
rate).
Broadcast
applications
were
made
in
5
gal/
A
using
ground
equipment.

Samples
were
bagged
and
frozen
(
temperature
unspecified)
within
2.5
hours
of
collection
and
were
stored
frozen
for
a
maximum
of
9
months
prior
to
analysis.
HED
noted
that
storage
stability
data
on
13
matrices
submitted
with
the
residue
data
on
tomatoes,
broccoli,
mustard
greens,
and
cabbage
(
D219970,
4/
9/
96,
L.
Cheng)
indicate
that
sethoxydim
and
metabolites
are
stable
for
3­
5
years.
Thus,
adequate
supporting
storage
stability
data
were
available
to
cover
the
storage
intervals
reflected
in
the
field
trials.

Method
A9003
was
used
for
sample
analysis.
Concurrent
recoveries
were
adequate;
recoveries
ranged
from
70%
to
92%
for
MSO
and
from
77%
to
89%
for
5­
OH­
MSO2.
Residues
in
grapes
resulting
from
treatment
with
sethoxydim
ranged
from
<
0.1
to
0.56
ppm.
The
available
data
are
adequate
to
support
the
current
tolerance
level
of
1.0
ppm
for
grape.

Horseradish
No
MRID
number
(
D251542,
G.
J.
Herndon,
12/
10/
98)

In
PP#
9E5049,
the
registrant
submitted
a
request
for
establishment
of
a
tolerance
for
residues
of
sethoxydim
and
its
metabolites
in/
on
horseradish
at
4.0
ppm
based
on
existing
data
from
sugar
beets,
carrots,
potatoes
and
sweet
potatoes.
HED
concluded
that
since
the
cultural
practices
for
horseradish
are
in
line
with
those
of
carrots,
potatoes,
sugar
beets,
and
sweet
potatoes,
the
residue
data
requirements
for
horseradish
were
satisfied
based
on
residue
data
for
these
crops
(
D251542,
G.
J.
Herndon,
12/
10/
98).

Juneberry,
Lingonberry
and
Salal
(
D278583,
N.
Dodd,
7/
19/
02)

No
residue
data
were
submitted
for
these
crops.
The
registrant
proposed
to
use
residue
data
on
blueberry
and
caneberry
to
support
use
on
lingonberry,
juneberry,
and
salal.
HED
concluded
that
residue
data
for
sethoxydim
on
blueberries
could
be
used
for
lingonberries,
juneberries,
and
salal
given
that
similar
use
patterns.
Based
on
the
blueberry
residue
data,
HED
noted
that
residues
of
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
are
not
expected
to
exceed
the
proposed
tolerance
of
5.0
ppm
in
lingonberry,
juneberry,
and
salal.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
49
of
101
Lentil,
seed
No
MRID
number
(
D165411,
L.
Cheng,
9/
23/
91;
D237724,
L.
Cheng,
7/
28/
97)

In
D165411
(
L.
Cheng,
9/
23/
91),
HED
noted
that
samples
from
lentil
field
trials
evaluated
in
the
Phase
IV
review
had
been
analyzed
by
Craven
Laboratories.
HED
also
indicated
that
the
use
pattern
of
sethoxydim
on
dry
peas
(
40
ppm,
30­
day
PHI)
is
similar
to
lentils
(
30
ppm,
50­
day
PHI),
and
therefore,
residue
data
generated
on
dry
peas
are
translatable
to
lentils.
Residue
data
for
dry
peas
(
MRID
43801414)
were
submitted
in
1995
and
found
acceptable
(
D237724,
L.
Cheng,
7/
28/
97).
The
20­
day
longer
PHI
for
lentils
supports
a
lower
tolerance
level
for
lentils
than
for
dry
pea.
Thus,
the
available
data
are
adequate
to
support
the
established
30
ppm
tolerance
level
for
lentil,
seed.

Nectarine
MRID
41236404
(
PP9F3804/
PP9H5589,
S.
Inasi,
8/
8/
90)

For
nectarines,
one
field
trial
was
conducted
in
CA.
Nectarines
were
harvested
17
days
after
the
last
of
two
applications
of
sethoxydim
at
0.5
lb
ai/
A.
Only
one
nectarine
sample
was
analyzed;
the
total
residue
was
<
0.1
ppm.
HED
determined
that
the
residue
data
from
the
analysis
of
peaches
(
13
samples)
can
be
translated
to
nectarines.

Peach
MRID
41236402
(
PP9F3804/
PP9H5589,
S.
Inasi,
8/
8/
90)

For
peaches,
6
field
trials
were
conducted
in
6
states
at
1­
2X
dose
rates
with
a
PHI
of
10­
89
days.
Samples
were
store
for
up
to
45
months.
The
registrant
submitted
freezer
storage
stability
data
for
cherries
fortified
with
1.0
ppm
each
of
MSO
and
5­
OH­
MSO2
that
indicated
that
these
metabolites
are
stable
for
at
least
26­
33
months.

Method
30
G
was
used
for
analysis.
Samples
of
stone
fruits
were
fortified
with
0.05,
0.5
and
1.0
ppm
of
sethoxydim,
MSO
and
5­
OH­
MSO2;
recovery
for
residues
of
sethoxydim
and
its
metabolites
in/
on
sweet
and
sour
cherries
and
peaches
ranged
from
74­
108
percent
at
all
three
levels.
Recovery
of
these
metabolites
from
plums
at
all
three
levels
ranged
from
84­
92%.
HED
noted
that
these
data
were
adequate
to
establish
that
recoveries
of
the
herbicide
and
its
metabolites
in/
on
sweet
and
sour
cherries,
peaches
and
plums
were
within
acceptable
range.

For
peaches,
the
total
sethoxydim
residues
detected
in
all
thirteen
treated
samples
analyzed
were
less
than
0.1
ppm.

Peanut
MRID
43801408
(
D237724,
L.
Cheng,
7/
28/
97)

The
Phase
IV
review
indicates
that
peanut
crop
field
trials
(
MRID
92166063)
were
conducted
in
all
the
major
peanut
growing
areas
using
ground
equipment
only
(
aerial
mode
of
application
permitted).
Sethoxydim
was
applied
at
1
x
0.3
+
1
x
0.2
lb
ai/
A
(
label
maximum
of
0.47
lb
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
50
of
101
ai/
A/
season).
Samples
of
nuts
and
hulls
were
collected
at
20­
47
days
(
label
PHI=
40
days)
and
contained
less
than
25
ppm
(
nut
meat)
and
5
ppm
(
hulls)
residues.
Subsequently,
it
was
determined
that
some
of
the
data
was
analyzed
by
Craven
Laboratories.
To
replace
the
existing
peanut
data
generated
by
Craven
Laboratories,
three
field
trials
on
peanuts
were
conducted
in
GA,
NC,
and
TX
(
MRID
4381408).
Peanuts
were
harvested
40
days
after
two
applications
of
the
1.5
lb/
gal
EC
formulation,
the
first
at
0.09
lb
ai/
A
and
the
second
at
0.38
lb
ai/
A
(
1x
the
maximum
registered
seasonal
rate).
Broadcast
applications
were
made
in
5
gal/
A
using
ground
equipment.

Samples
were
bagged
and
frozen
(
temperature
unspecified)
within
2.5
hours
of
collection
and
were
stored
frozen
for
a
maximum
of
10
months.
Storage
stability
data
for
soybeans
indicate
that
sethoxydim
and
its
metabolites
are
stable
for
up
to
24
months
and
are
translatable
to
peanuts.

Sample
analysis
was
performed
using
GC/
FPD
Method
30.
Concurrent
recoveries
were
adequate;
for
peanut
nutmeat
recoveries
were
120%
and
86%
for
MSO
and
139%
and
93%
for
5­
OHMSO2
for
peanut
hulls
recoveries
were
96%
and
72%
for
MSO
and
97%
and
89%
for
5­
OHMSO2
.
Residues
in
peanut
nutmeat
were
5.3­
12.5
ppm
and
these
data
are
adequate
to
support
the
25
ppm
tolerance
for
peanuts.

Pea,
succulent
MRID
43801415(
D237724,
L.
Cheng,
7/
28/
97)

Studies
were
conducted
to
replace
existing
succulent
pea
residue
data
generated
by
Craven
Laboratories.
Field
trials
on
peas
were
conducted
in
CA(
2),
DE,
ID,
MN,
OR,
and
WI.
Pea
pods
were
harvested
15
days
after
the
second
of
two
applications
of
the
1.5
lb/
gal
EC
formulation,
the
first
at
0.28
lb
ai/
A
and
the
second
14
days
later
at
0.47
lb
ai/
A
(
1x
the
maximum
registered
seasonal
rate).
Broadcast
applications
were
made
in
5
gal/
A
using
ground
equipment.

Samples
of
bean
pods
were
bagged
and
frozen
within
4.5
hours
of
collection.
Samples
were
stored
frozen
for
a
maximum
of
15
months
prior
to
analysis.
HED
noted
that
storage
stability
data
on
13
matrices
submitted
with
the
residue
data
on
tomatoes,
broccoli,
mustard
greens,
and
cabbage
(
D219970,
4/
9/
96,
L.
Cheng)
indicate
that
sethoxydim
and
metabolites
are
stable
for
3­
5
years.
Thus,
adequate
supporting
storage
stability
data
were
available
to
cover
the
storage
intervals
reflected
in
the
field
trials.

Method
30G
was
used
for
sample
analysis.
Concurrent
recoveries
were
adequate;
recoveries
ranged
from
65%
to
101%
for
MSO
and
from
86%
to
121%
for
5­
OH­
MSO2.
Residues
in
succulent
peas
were
1.4­
7.0
ppm.
The
available
data
are
adequate
to
support
the
established
10
ppm
tolerance
for
residues
of
sethoxydim
in/
on
succulent
peas.

Pea,
dry,
seed
MRID
43801414
(
D237724,
L.
Cheng,
7/
28/
97)
All
samples
from
the
original
U.
S.
residue
trials
were
analyzed
by
Craven.
Non­
Craven
pea
residue
trials
were
conducted
in
Manitoba,
Saskatchewan,
Canada
and
used
less
than
the
maximum
use
pattern.
To
replace
the
existing
dry
pea
residue
data
generated
by
Craven
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
51
of
101
Laboratories,
field
trials
on
dry
peas
were
conducted
in
ID
and
WA.
Peas
were
harvested
30
days
after
the
second
of
two
applications
of
the
1.5
lb/
gal
EC
formulation,
the
first
at
0.28
lb
ai/
A
and
the
second
14
days
later
at
0.47
lb
ai/
A
(
1x
the
maximum
registered
seasonal
rate).
Broadcast
applications
were
made
in
5
gal/
A
using
ground
equipment.

Samples
of
peas
were
bagged
and
frozen
(
temperature
unspecified)
within
1.75
hours
of
collection.
Samples
were
stored
frozen
for
a
maximum
of
13
months
prior
to
analysis.
HED
noted
that
storage
stability
data
on
13
matrices
submitted
with
the
residue
data
on
tomatoes,
broccoli,
mustard
greens,
and
cabbage
(
D219970,
4/
9/
96,
L.
Cheng)
indicate
that
sethoxydim
and
metabolites
are
stable
for
3­
5
years.
Thus,
adequate
supporting
storage
stability
data
were
available
to
cover
the
storage
intervals
reflected
in
the
field
trials.

Method
30
was
used
for
analysis.
Concurrent
recoveries
were
adequate;
recoveries
ranged
from
68­
95%
for
MSO
and
from
80­
122%
for
5­
OH­
MSO2.
Residues
in
dry
peas
were
13.8
and
14.3
ppm.
The
available
data
are
adequate
to
support
the
established
40
ppm
tolerance
for
residues
of
sethoxydim
in/
on
dry
pea,
seed.

Pea
forage
and
hay
MRIDs
43801414
and
43801415
(
D237724,
L.
Cheng,
7/
28/
97)

In
conjunction
with
each
of
the
field
trials
on
succulent
and
dry
peas,
the
registrant
provided
data
on
pea
vines
(
forage)
and
hay.
Vine
and
hay
samples
were
harvested
15­
30
days
following
two
applications
of
the
1.5
lb/
gal
EC
formulation
at
0.28
and
0.47
lb
ai/
A.
The
application
rates
and
PHIs
all
reflected
the
current
label
rates
for
these
crops.

Sethoxydim
residues
in
legume
forage
samples
were
analyzed
using
BASF
Methods
30G
and
30H
following
up
to
15
months
in
frozen
storage.
Concurrent
recoveries
were
adequate;
for
pea
forage
recoveries
were
63­
100%
for
MSO
and
67­
84%
for
5­
OH­
MSO2;
for
pea
hay
recoveries
were
70­
122%
for
MSO
and
83­
108%
for
5­
OH­
MSO2
.

Total
residues
of
sethoxydim
were
reported
for
dry
pea
forage
(
3.0
&
5.4
ppm)
and
hay
samples
(
11.4
&
12.8
ppm).
In
the
succulent
pea
forage
and
hay
samples,
total
residues
of
sethoxydim
ranged
from
1.8
­
9.4
ppm
and
4.1
­
24.9
ppm,
respectively.
The
data
are
adequate
to
support
tolerances
of
20
and
40
ppm
for
pea
forage
and
hay,
respectively.

Peppermint,
tops/
Spearmint,
tops
MRID
42101701
(
D172349,
W.
D.
Wassell,
2/
11/
92)

Nine
crop
field
trials
were
conducted
during
1988
in
six
states
(
IN
(
2),
MI,
OR
(
2),
UT,
WA
(
2)
and
WI)
to
provide
residue
chemistry
data
to
support
the
registration
of
sethoxydim
for
use
on
mint.
Four
field
trials
used
spearmint
and
five
used
peppermint.
In
all
trials,
two
applications
of
Poast
®
Herbicide
were
made
using
ground
equipment
at
rates
of
0.5
lbs
ai/
A.
For
all
applications,
a
crop
oil
concentrate
was
used
at
a
rate
of
1
quart/
A.
Retreatment
intervals
of
14
to
18
days
were
observed
and
all
second
applications
were
made
20
days
prior
to
cutting
of
the
mint.
Whole
green
plant
samples
were
collected
on
the
day
of
cutting.
Plants
were
allowed
to
air
dry
for
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
52
of
101
one
to
four
days
and
then
collected
as
mint
hay
samples.
In
one
field
trial,
Washington,
mint
hay
samples
were
not
collected
since
mint
in
this
area
is
normally
processed
the
same
day
as
cutting.

Mint
green
plant,
mint
hay
and
mint
process
samples
were
stored
from
harvest
to
analysis
for
a
maximum
of
21,
20
and
17
months,
respectively.
Previously
submitted
storage
stability
data
for
alfalfa
hay,
corn
forage
and
dry
beans
were
cited
by
the
registrant;
however,
HED
concluded
that
the
cited
data
were
not
adequate
to
demonstrate
the
stability
of
sethoxydim
per
se
in
or
on
mint
commodities
over
the
period
between
harvest
and
analysis
and
requested
the
submission
of
storage
stability
data
for
mint
or
a
similar
crop
that
reflects
the
interval
and
conditions
of
storage
for
the
samples
of
the
submitted
studies.
Subsequently,
storage
stability
data
for
13
crop
matrices
were
submitted
which
demonstrate
the
stability
of
sethoxydim
and
it's
metabolites
for
up
to
3
to
5
years.
These
data
may
be
translatable
to
mint.

Mint
green
plant
and
mint
hay
samples
were
analyzed
according
to
modified
versions
of
BASF
Methods
30G
and
30H,
respectively,
or
according
to
BASF
Method
278
for
either
matrix.
Concurrent
recoveries
were
adequate;
for
mint
green
plant
samples,
recoveries
were
74­
122%
(
97
±
17%)
for
MSO
and
78­
110%
(
95
±
12%)
for
5­
OH­
MSO2;
for
mint
hay
samples,
recoveries
were
61­
105%
(
82
±
16%)
for
MSO
and
60­
111%
(
89
±
15%)
for
5­
OH­
MSO2.

Total
residues
were
2.5­
25.9
ppm
and
2.5­
9.9
ppm
in
mint
green
plant
and
mint
hay
samples,
respectively.
The
available
data
are
adequate
to
support
the
current
tolerance
level
of
30
ppm
for
"
peppermint,
tops"
and
"
spearmint,
tops".

Pistachio
No
MRID
number
(
D256970,
N.
Dodd,
8/
9/
01)

No
residue
data
have
been
submitted
for
pistachios.
HED
noted
that
the
proposed
use
of
Poast
®
Herbicide
on
pistachios
is
the
same
as
the
registered
use
on
the
tree
nuts
crop
group
(
almonds,
pecans,
walnuts)
with
respect
to
lb
ai/
A/
application,
lb
ai/
A/
season,
and
PHI.
Residue
data
for
sethoxydim
and
its
metabolites
on
almonds
(
nuts
and
hulls)
(
MRID
41428501),
pecans
(
MRID
41428502),
and
walnuts
(
MRID
41428503)
were
previously
reviewed
in
connection
with
establishment
of
the
sethoxydim
tolerance
on
the
tree
nuts
crop
group
at
0.2
ppm
(
PP#
0F3855,
M.
J.
Nelson,
2/
7/
91).
HED
determined
that
data
on
walnuts,
pecans,
and
almonds
can
be
used
in
lieu
of
residue
data
on
pistachios
to
support
the
proposed
tolerance
on
pistachios.
Thus,
the
existing
tree
nut
tolerance
level
of
0.2
ppm
is
adequate
to
cover
the
pistachio
use.

Rhubarb
MRID
41072001
One
rhubarb
field
trial
was
conducted
in
MI
in
1986.
Due
to
the
low
acreage
of
rhubarb
and
the
regional
registration
of
rhubarb,
the
one
field
trial
is
adequate
to
satisfy
reregistration
data
requirements.
Sethoxydim
was
applied
at
a
rate
of
0.3
lbs/
ai/
A
as
the
formulation
Poast
1.5
EC.
The
maximum
combined
residues
of
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
in
rhubarb
were
0.24
and
0.16
ppm
for
samples
harvested
following
15­
and
30­
day
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
53
of
101
PHIs,
respectively.
These
residue
levels
indicate
that
the
existing
tolerance
level
of
0.3
ppm
is
adequate
for
rhubarb.

Safflower
MRID
44864501
(
D257559,
N.
Dodd,
1/
24/
02)

Four
field
trial
studies
using
safflower
were
conducted
in
1988.
The
studies
were
conducted
in
Region
10
(
1
study),
Region
5
(
2
studies),
and
Region
7
(
1
study).
In
the
trials,
sethoxydim
(
Poast
®
1E)
was
applied
twice
to
each
test
plot
at
a
rate
of
0.5
lb
ai/
A/
application
(
total
of
1.0
lb
ai/
A/
season).
At
a
PHI
of
30
days,
maximum
residues
of
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
in
safflower
seed
were
12
ppm.

Based
on
the
storage
stability
of
sethoxydim,
MSO2,
M2SO2,
and
5­
OH­
MSO2
in
soybean
seeds
for
24
months,
HED
concludes
that
residues
of
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
are
stable
in
safflower
seed
and
meal
for
24
months,
which
is
longer
than
the
time
of
safflower
seed
and
meal
sample
storage.

The
available
field
trial
data
indicate
that
residues
of
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
will
not
exceed
15
ppm
in/
on
safflower
as
a
result
of
the
proposed
use;
however,
an
adequate
number
of
field
trials
have
not
been
submitted.
Under
OPPTS
860.1500,
five
field
trials
are
required
for
safflower,
with
suggested
distribution
in
Region
7
(
2
trials)
and
Region
10
(
3
trials).
Therefore,
two
additional
studies
from
Region
10
should
be
submitted.
Pending
submission
and
review
of
the
Region
10
trials,
the
established
tolerance
level
of
15
ppm
is
adequate
for
sunflower,
seed.

Soybean
Seed
MRIDs
100535
and
43801412
(
D237724,
L.
Cheng,
7/
28/
97;
D182749,
B.
Schneider,
11/
23/
92)

In
1991,
HED
determined
that
some
residue
data
for
soybean
seed
and
hay
evaluated
in
the
Phase
IV
review
had
been
generated
by
Craven
Laboratories.
In
1992,
the
registrant
submitted
a
revised
label
proposing
a
75­
day
PHI
and
resubmitted
the
non­
Craven
data
to
support
the
revised
label.
The
non­
Craven
data
were
generated
from
ten
soybean
seed
field
trials
(
MRID
100535)
conducted
in
five
states
(
IL,
MI,
MO,
NC,
and
NJ).
Only
data
from
the
tests
conducted
at
PHIs
ranging
from
17­
78
days
were
resubmitted.
All
of
the
field
trials
were
applied
as
ground
application
directly
to
the
emerged
weeds
using
two
applications
of
sethoxydim
(
Poast
®
Herbicide)
at
0.5
lb
a.
i./
A
(
1X)
with
PHIs
ranging
from
17­
78
days.
All
samples
analyzed
for
seed
after
harvest
were
stored
frozen
at
<
­
5
°
C
until
analysis.
The
total
sethoxydim
residue
(
calculated
as
sum
of
DME
plus
DME­
OH)
in
soybean
seed
ranged
from
2.52
­
8.7
ppm.
At
78
and
75
day
PHIs,
the
sethoxydim
residues
were
3.5
and
6.5
ppm,
respectively.

In
MRID
43801412,
the
registrant
submitted
the
results
of
studies
conducted
to
supplement
existing
soybean
residue
data
in
order
to
satisfy
geographic
representation
and
PHI
amendment.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
54
of
101
Field
trials
on
soybeans
were
conducted
in
LA,
TN,
AR,
IA,
and
MN.
Soybeans
were
harvested
75
days
after
the
second
of
two
applications
of
the
1.5
lb/
gal
EC
formulation,
each
at
0.47
lb
ai/
A
(
1x
the
maximum
registered
rate).
Broadcast
applications
were
made
in
5
gal/
A
using
ground
equipment.
Samples
of
soybeans
were
bagged
and
frozen
(
temperature
unspecified)
within
2
hours
of
collection.
Samples
were
stored
frozen
for
a
maximum
of
9
months
prior
to
analysis
using
GC/
FPD
Method
30.
Total
residues
in
soybean
seed
ranged
from
0.4
­
15.2
ppm.
These
data
are
adequate
to
support
the
existing
tolerance
level
of
16
ppm
for
soybean,
seed.

Hay
MRIDs
153602
and
43801412
(
D237724,
L.
Cheng,
7/
28/
97)

As
indicated
above,
in
1992,
the
registrant
submitted
a
revised
label
proposing
a
75­
day
PHI
for
soybeans.
To
support
the
revised
label,
non­
Craven
data
for
soybean
hay
were
submitted.
These
data
were
generated
from
14
soybean
hay
field
trials
(
MRID
153602)
conducted
in
5
states
(
IL,
MI,
MN,
MO,
and
NJ).
These
field
trials
include
tests
conducted
at
PHI
ranging
from
32
to
78
days.
Samples
used
for
hay
were
cut
from
the
dried
soybean
stubble
in
the
field.
The
total
sethoxydim
residue
in
soybean
hay
ranged
from
2.01
ppm
to
6.49
ppm.
At
78
and
75
day
PHIs,
the
sethoxydim
residues
in
hay
averaged
2.40
ppm
and
2.49
ppm,
respectively.

In
43801412,
the
registrant
submitted
additional
residue
data
on
soybean
hay.
Hay
samples
were
harvested
at
the
same
time
as
the
seed,
75
days
following
two
applications
of
the
1.5
lb/
gal
EC
formulation,
each
at
0.47
lb
ai/
A.
Sethoxydim
residues
in
soybean
hay
were
analyzed
using
BASF
GC/
FPD
Methods
30H,
following
up
to
15
months
in
frozen
storage.
Concurrent
recoveries
were
adequate;
recoveries
were
68­
90%
for
MSO
and
80­
125%
for
5­
OH­
MSO2.
Total
residues
were
0.34­
2.23
ppm.
These
data
are
adequate
to
support
the
existing
tolerance
level
of
10
ppm
for
soybean,
hay.

Strawberry
MRID
41342801
(
Summary
in
92166066)

From
92166066
[
Analysis
by
Craven
Labs]
Ten
strawberry
field
trials
were
conducted
from
1982­
1985
in
CA
(
3
trials),
FL,
MI
(
2
trials),
MN,
and
NJ
(
3
trials).
The
application
rate
used
for
these
studies
was
0.5
lbs
ai/
A,
except
for
some
exaggerated
rate
trials
that
used
2
applications
at
0.5
lbs
ai/
A.
The
PHI
ranged
from
1­
34
days
in
the
reported
trials.
Analytical
method
30G
was
used
to
determine
the
total
residues
of
sethoxydim
and
its
metabolites.
Samples
were
stored
frozen
for
a
maximum
of
37
months
between
harvest
and
analysis.
A
strawberry
storage
stability
study
showed
no
significant
residue
loss
for
at
least
31
months
of
frozen
storage.
The
maximum
combined
residue
level
reported
for
treated
strawberries
was
3.6
ppm.

From
41342801
[
Analysis
by
Nippon
Soda.,
Ltd.]
Eleven
strawberry
field
trials
were
conducted
from
1988
in
CA
(
3
trials),
FL
(
2
trials),
IN,
MI,
NY,
OR,
PA,
and
WA.
The
number
and
geographical
distribution
of
the
strawberry
trials
is
adequate
to
satisfy
reregistration
data
requirements.
The
use
pattern
for
these
studies
consisted
of
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
55
of
101
2
applications
at
0.5
lbs
ai/
A,
with
a
PHI
of
7
days
and
a
RTI
of
21
days
(
except
for
one
FL
trial
and
the
WA
trial,
where
a
14
day
RTI
was
used).
This
rate
corresponds
to
2x
the
maximum
label
rate.
Analytical
method
30G
was
used
to
determine
the
total
residues
of
sethoxydim
and
its
metabolites.
Samples
were
stored
frozen
for
a
maximum
of
6
months
between
harvest
and
analysis.
A
strawberry
storage
stability
study
showed
no
significant
residue
loss
for
at
least
60
months
of
frozen
storage.
The
combined
residue
levels
found
for
treated
strawberries
ranged
from
2.4­
9.4
ppm,
with
a
mean
value
of
6.2
ppm.
These
results
support
the
established
strawberry
tolerance
level
of
10
ppm.

Sunflower,
seed
MRID
00131857
(
Summary
in
MRID
92166068)
(
L.
Cheng,
2/
25/
91)
Accession
Number
073424
(
RCB
#
943
and
944;
7/
17/
85;
M.
Firestone)

According
to
the
Phase
IV
review,
field
trials
using
sunflowers
were
conducted
were
conducted
in
ND,
MN,
TX,
IL
and
KS.
Rates
approximated
the
seasonal
maximum
(
1
x
0.47
lb
ai/
A)
and
sunflower
seeds
samples
were
harvested
33­
89
days
later
(
label
PHI=
70
days).

Additional
information
was
found
in
a
1985
memo
regarding
sunflower
crop
field
trial
data
(
Accession
Number
073424).
Trials
in
the
study
were
conducted
in
ND,
MN,
TX,
IL
and
KS
at
a
rate
of
0.5
lb
ai/
A/
season
and
at
PHI's
of
53
­
118
days.
Total
sethoxydim
residues
ranged
from
0.08­
5.8
ppm
in
the
sunflower
seeds
(
RCB
#
943
and
944;
7/
17/
85;
M.
Firestone).
These
results
are
adequate
to
support
the
established
tolerance
level
of
7.0
ppm
for
sunflower,
seed.

Nut,
Tree,
Group
14
MRID
No.
41428503
(
walnut),
41428502
(
pecan),
and
41428501
(
almond)
(
PP0F3855,
M.
J.
Nelson,
2/
7/
91)

In
support
of
the
establishment
of
a
tolerance
on
the
tree
nuts
crop
group
at
0.2
ppm,
residue
data
on
walnuts
(
MRID
41428503),
pecans
(
MRID
41428502),
and
almonds
(
MRID
41428501)
were
submitted.
Five
field
trials
with
English
walnuts
were
conducted
in
CA
and
OR
during
crop
years
1984
and
1985,
four
field
trials
with
pecans
were
conducted
during
1985
in
TX,
GA,
and
AL,
and
six
field
trials
with
almonds
were
conducted
during
1984,
1985,
and
1986
in
CA.
Multiple
applications
of
Poast
®
Herbicide
were
made
to
the
crops
at
1x
or
2x
the
maximum
recommended
label
rate.
Total
application
rates
were
1.5
to
4
lb
ai/
A
for
walnuts
and
almonds
and
2
lb
ai/
A
for
pecans.
PHI's
ranged
from
11
to
16
days
for
walnuts
and
pecans
and
from
9
to
18
days
for
almonds.

Nut
residue
samples
were
stored
frozen
between
sampling
and
analysis.
Most
of
the
residue
samples
were
stored
for

35
months.
The
registrant
referenced
storage
stability
data
from
other
crops
(
strawberries,
cherries,
soybeans,
peanut
hay,
and
succulent
peas)
that
indicated
stability
for
sethoxydim
and
its
metabolites
for
up
to
a
60­
month
storage
period.
HED
concluded
that
the
stability
of
sethoxydim
and
metabolites
in
nuts
is
adequately
supported
by
the
Craven
replacement
storage
stability
data
that
shows
stability
in
various
frozen
commodities
for
3­
5
years
(
D256970,
N.
Dodd,
8/
9/
01).
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
56
of
101
Residues
were
below
the
limit
of
quantitation
(<
0.1
ppm)
for
both
DME
and
DME­
OH
in
all
samples.
Hence,
the
established
tolerance
level
of
0.2
ppm
is
appropriate
for
tree
nuts.

Tuberous
and
corm
vegetable
crop
subgroup
1C
Potatoes
MRID
43801407
(
D237724,
L.
Cheng,
7/
28/
97)

The
field
trials
(
MRID
43801407)
generated
to
replace
existing
potato
residue
data
generated
by
Craven
Laboratories
on
potatoes
were
conducted
in
CA(
2),
CO,
ID,
ME,
MN,
ND,
WA,
and
WI.
Potatoes
were
harvested
30
days
after
the
second
of
two
applications
of
the
1.5
lb/
gal
EC
at
0.47
lb
ai/
A
(
1x
the
maximum
registered
rate).

Samples
were
stored
frozen
for
a
maximum
of
6.5
months
prior
to
analysis
using
GC/
FPD
Method
A9003.
Concurrent
recoveries
were
adequate;
recoveries
were
74­
101%
for
MSO
and
75­
105%
for
5­
OH­
MSO2.
HED
noted
that
storage
stability
data
on
13
matrices
submitted
with
the
residue
data
on
tomatoes,
broccoli,
mustard
greens,
and
cabbage
(
D219970,
4/
9/
96,
L.
Cheng)
indicate
that
sethoxydim
and
metabolites
are
stable
for
3­
5
years.
Thus,
adequate
supporting
storage
stability
data
were
available
to
cover
the
storage
intervals
reflected
in
the
field
trials.

In
MRID
43801407,
total
sethoxydim
residues
in/
on
potatoes
were
0.25­
2.95
ppm.
These
data
are
adequate
to
support
the
established
tolerance
of
4.0
ppm
for
sethoxydim
residues
in/
on
"
vegetable,
tuberous
and
corm,
subgroup
1C".

Vegetable,
brassica,
leafy,
group
5
The
residue
data
reviewed
in
the
Phase
IV
for
mustard
greens,
broccoli
and
cabbage
were
generated
by
Craven
Laboratories.
In
support
of
the
establishment
of
a
tolerance
on
the
vegetable
brassica
crop
group
at
5.0
ppm,
replacement
residue
data
on
mustard
greens,
broccoli
and
cabbage
were
submitted
(
MRID
43801404,
43801403,
and
43801405).
Samples
were
analyzed
by
BASF
Analytical
Method
A9003.
Residue
data
were
supported
by
adequate
concurrent
recovery
data
(
mustard
greens
­
recoveries
of
68­
90%
for
MSO
and
80­
125%
for
5­
OH­
MSO2;
cabbage
­
recoveries
of
81­
108%
for
MSO
and
77­
124%
for
5­
OH­
MSO2;
broccoli
­
recoveries
of
70­
94%
for
MSO
and
73­
121%
for
5­
OH­
MSO2).
Additionally,
samples
were
analyzed
within
the
period
covered
by
frozen
storage
stability
data
submitted
by
the
registrant.
The
frozen
storage
stability
study
(
MRID
43801401)
indicated
that
MSO
was
stable
in
corn
grain
and
forage,
lettuce,
oranges,
tomatoes,
cucumbers,
succulent
and
dry
beans,
potatoes,
onions,
apples,
cherries,
and
strawberries
for
5
years
under
frozen
conditions
and
5­
OH­
MSO2
was
stable
in
cherries,
strawberries,
and
tomatoes
for
3
years,
and
in
succulent
beans
and
potatoes
for
4
years
under
frozen
conditions.

A
summary
of
the
residue
data
for
mustard
greens,
broccoli,
and
cabbage
is
provided
below.
All
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
57
of
101
trials
were
conducted
using
a
total
of
0.56
lb
ai/
A
(
2
applications
at
0.28
lb
ai/
A)
and
a
PHI
of
30
days.
Overall,
the
combined
residues
of
sethoxydim
were
detected
at
a
maximum
of
4.51
ppm
(
broccoli).
Taken
together,
the
residue
data
on
mustard
greens,
broccoli,
and
cabbage
are
adequate
to
support
the
established
tolerance
level
of
5.0
ppm
for
"
vegetable,
brassica,
leafy,
group
5".

Mustard
Greens
MRID
43801404
(
D219970,
L.
Cheng,
4/
9/
96;
D229627,
L.
Cheng,
4/
25/
97)

The
registrant
submitted
results
from
field
trials
conducted
in
TX,
LA,
and
MI
to
replace
the
residue
data
generated
by
Craven
laboratories,
which
showed
residues
in
mustard
greens
ranging
from
0.10
­
0.54
ppm
(
D198048,
L.
Cheng,
4/
26/
94).
Two
applications
were
made
at
each
site
at
0.28
lb
ai/
A/
application
for
a
total
of
0.56
lb
ai/
A,
the
seasonal
maximum
label
rate.
The
crop
was
harvested
30
days
(
label
PHI)
after
the
second
broadcast
treatment
in
5
gal/
A
spray
volume.
At
harvest
each
sample
consisted
of
at
least
2.5
lbs
of
mustard
greens
taken
from
12
different
plants
at
12
locations
within
the
plot.
Four
months
elapsed
between
harvest
and
analysis
of
samples.
Combined
residues
of
sethoxydim
and
its
metabolites
in
mustard
green
following
label
treatment
were
<
0.10
ppm.
In
a
memo
dated
4/
25/
97
(
D229627,
L.
Cheng)
CBRS
concluded
that
the
crop
field
trial
reregistration
requirement
for
mustard
greens
was
satisfied.

Broccoli
MRID
43801403
(
D219970,
L.
Cheng,
4/
9/
96)

The
study
was
conducted
to
replace
existing
broccoli
residue
data
generated
in
the
Craven
laboratories.
Field
trials
were
conducted
in
CA,
TX,
and
OR
to
cover
the
major
growing
areas
in
the
U.
S.
Two
applications
were
made
at
each
site
at
0.28
lb
ai/
A/
application
for
a
total
of
0.56
lb
ai/
A,
the
seasonal
maximum
label
rate.
The
crop
was
harvested
30
days
(
label
PHI)
after
the
second
broadcast
treatment
in
5
gal/
A
spray
volume.
At
harvest
each
sample
consisted
of
at
least
2.5
lbs
of
broccoli
heads
and
stalks
taken
from
12
different
plants
at
12
different
locations
within
the
plot.
Seven
months
elapsed
between
harvest
and
analysis
of
samples.
Combined
residues
of
sethoxydim
and
its
metabolites
in
broccoli
following
label
treatment
range
from
<
0.10
­
4.51
ppm.

Cabbage
MRID
43801405
(
D219970,
L.
Cheng,
4/
9/
96)

The
field
trials
were
conducted
in
CA,
NY,
FL,
TX,
WI,
NJ,
and
GA
to
replace
the
residue
data
generated
by
Craven
laboratories.
Two
applications
were
made
at
each
site
at
0.28
lb
ai/
A/
application
for
a
total
of
0.56
lb
ai/
A,
the
seasonal
maximum
label
rate.
The
crop
was
harvested
30
days
(
label
PHI)
after
the
second
broadcast
treatment
in
5
gal/
A
spray
volume.
At
harvest
each
sample
consisted
of
at
least
2.5
lbs
of
cabbage
leaves
taken
from
12
different
untrimmed
cabbage
heads
located
within
the
plot.
Eight
months
lapsed
between
harvest
and
sample
analysis.
Combined
residues
of
sethoxydim
and
its
metabolites
in
cabbage
following
label
treatment
range
from
0.4
­
0.85
ppm.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
58
of
101
Vegetable,
bulb,
group
3
MRIDs
40783000,
40783001
and
40783002
(
D185410,
M.
I.
Rodriguez,
8/
25/
93)

The
representative
crops
for
the
bulb
vegetable
crop
group
are
green
onions
and
bulb
onions.
Crop
field
trial
data
were
submitted
for
these
two
crops
and
garlic,
and
the
results
are
briefly
summarized
below.

Six
field
trials
for
garlic
were
conducted
in
1986
and
1987
in
CA
and
OR.
The
trials
were
conducted
using
3
applications
at
0.3
lb
ai/
A/
application
and
a
PHI
of
36
to
32
days.
Residue
data
for
garlic
showed
maximum
total
residues
of
<
0.80
ppm.
Eight
field
trials
for
green
onions
were
conducted
in
AZ,
CA,
and
TX.
The
trials
were
conducted
using
2
applications
at
0.3
lb
or
5
lb
ai/
A/
application
and
a
PHI
of
22
to
34
days.
Residue
data
for
green
onion
showed
maximum
total
residues
of
<
0.36
ppm.
Eighteen
field
trials
for
bulb
onions
were
conducted
in
CA,
CO,
ID,
MI,
NY,
OR,
TX
and
WA.
The
trials
were
conducted
using
3
applications
at
0.3
lb
ai/
A/
application
and
a
PHI
of
14
or
52
days
(
n=
4)
or
24
to
33
days
(
n
=
44).
Residue
data
for
bulb
onions
showed
maximum
total
residues
of
<
0.58
ppm.
Overall,
the
results
support
the
current
tolerance
level
of
1.0
ppm
for
crop
group
3.

Vegetable,
cucurbit,
group
9
According
to
the
Phase
IV
review
(
L.
Cheng,
2/
22/
91),
crop
field
trials
were
conducted
in
CA,
FL
and
MS
for
cucumbers,
in
CA
for
cantaloupes,
and
in
CA,
VA,
FL,
MS
and
WI
for
summer
squash
(
MRID
00162812,
summarized
in
MRID
92166055).
Two
treatments
at
0.3
lb
ai/
A
were
applied
to
cucumbers,
summer
squash
and
cantaloupes.
The
Phase
IV
determined
that
additional
field
trials
for
cucumbers,
cantaloupes,
and
summer
squash
were
required
to
satisfy
geographical
representation
requirements.
A
summary
of
this
residue
data
is
provided
below.
All
trials
were
conducted
using
a
total
of
0.56
lb
ai/
A
(
2
applications
at
0.28
lb
ai/
A)
and
a
PHI
of
14
days.
Overall,
the
available
data
support
the
current
tolerance
level
of
4.0
ppm
for
crop
group
9.

Summer
Squash
MRID
43062202
(
D198048,
L.
Cheng,
4/
26/
94)

Field
trials
were
conducted
in
GA,
MI,
NY,
OR,
and
TX
at
2
x
0.28
lb
ai/
A
and
a
3­
week
interval.
Samples
were
harvested
14
days
after
the
second
treatment
and
stored
for
up
to
7
months
before
residue
analyses.
Based
on
tomato
storage
data,
HED
concluded
that
sethoxydim
metabolites
were
stable
during
the
7
months
storage
period.

Samples
were
analyzed
by
Method
A9003.
Concurrent
recoveries
were
adequate;
recoveries
were
70­
108%
(
86.5
±
13.1%)
for
MSO
and
65­
98%
(
83.5
±
12.8%)
for
5­
OH­
MSO2.
Residues
resulting
from
treatment
of
summer
squash
with
sethoxydim
ranged
from
0.35­
2.15
ppm.

Cantaloupe
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
59
of
101
MRID
43062203
(
D198048,
L.
Cheng,
4/
26/
94)

Field
trials
were
conducted
in
GA,
MI,
and
TX
at
2
x
0.28
lb
ai/
A
and
a
21­
day
interval.
Samples
were
harvested
14
days
after
the
second
treatment
and
stored
for
up
to
7
months
before
residue
analyses.
Based
on
tomato
storage
data,
HED
concluded
that
sethoxydim
metabolites
are
stable
during
the
7
months
storage
period.

Samples
were
analyzed
by
Method
A9003.
Concurrent
recoveries
were
adequate;
recoveries
were
73­
119%
(
85.6
±
15.9%)
for
MSO
and
66­
109%
(
76.6
±
14.9%)
for
5­
OH­
MSO2.
Residues
resulting
from
treatment
of
cantaloupes
with
sethoxydim
ranged
from
0.40­
3.03
ppm.

Cucumbers
MRID
43282401
(
D205049,
L.
Cheng,
12/
1/
94)

Field
trials
were
conducted
in
MI,
NC,
NY,
NJ,
OH,
and
TX.
Two
applications
at
0.28
lb
ai/
A
were
made
at
roughly
a
20­
day
interval
using
a
ground
sprayer.
Spray
volume
was
5
gpa
and
spray
pressure
ranged
from
40
to
60
psi.
The
first
applications
were
made
35­
60
days
after
planting.
Cucumbers
were
all
harvested
14
days
after
the
second
application.
A
sample
consisted
of
at
least
16
fruit.
Plants
were
selected
from
both
sides
of
eight
separate
vines
throughout
the
plot
excluding
the
outer
edges.
A
maximum
of
6
months
lapsed
between
harvest
and
analysis
of
the
samples.
Storage
stability
of
MSO
and
MSO2
in
cucumbers
were
provided
by
the
registrant
and
adequately
supported
the
storage
interval
used
in
the
field
trials.

Residue
samples
were
analyzed
by
BASF
Method
A9003.
Controls
were
all
less
than
0.05
ppm
parent
equivalents
for
each
analyte.
Control
samples
were
fortified
with
MSO
and
5­
OH­
MSO2
at
0.05,
2.0
and
5.0
ppm.
The
overall
mean
recovery
was
80%
(
n=
12).
Residues
resulting
from
treatment
of
cucumbers
with
sethoxydim
ranged
from
0.14­
1.89
ppm.

Vegetable,
fruiting,
group
8
Field
trials
were
conducted
on
tomatoes
and
peppers
to
establish
a
tolerance
for
the
fruiting
vegetable
crop
group.
Trials
were
conducted
in
FL,
CA,
SC,
TX
and
MI
for
tomatoes,
and
in
FL,
CA,
TX,
NJ
and
MI
for
bell
peppers
(
92166057).
For
tomatoes,
sethoxydim
was
applied
at
and
exceeding
the
label
rate
of
3
x
0.28
lb
ai/
A.
Samples
were
collected
10­
22
days
after
treatment
(
label
PHI=
20
days).
For
bell
peppers,
applications
were
made
at
3
x
0.3
lb
ai/
A
or
2
x
0.5
lb
ai/
A.
Samples
were
collected
at
18­
22
days
after
treatment.
The
Phase
IV
review
determined
that
additional
trials
on
tomatoes
were
needed
to
satisfy
geographical
representation
requirements.
Summaries
of
the
additional
studies
are
provided
below.
These
studies
were
conducted
using
a
total
application
rate
of
0.84
lb
ai/
A
(
3
applications
at
a
rate
of
0.28
lb
ai/
A)
and
a
PHI
of
20
days.
In
the
more
recent
studies
submitted,
total
residues
were
a
maximum
of
2.26
ppm
(
peppers).
Overall,
the
results
support
the
current
sethoxydim
tolerance
level
of
4.0
ppm
for
crop
group
8.

Tomatoes
MRID
43062201
(
D198048,
L.
Cheng,
4/
26/
94)
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
60
of
101
Trials
were
conducted
in
OH,
PA
and
NJ
at
3
x
0.28
lb
ai/
A
and
at
3­
week
intervals
as
specified
in
the
Phase
IV
review.
Tomatoes
were
harvested
20
days
after
the
last
application.
Samples
were
stored
for
up
to
5
months
before
analysis.
Storage
stability
data
previously
collected
indicate
stability
of
sethoxydim
metabolites
during
this
period.

Residue
samples
were
analyzed
by
BASF
Method
A9003.
The
limit
of
quantitation
for
each
analyte
was
reported
to
be
0.05
ppm
sethoxydim
equivalents.
Controls
were
all
less
than
0.05
ppm
MSO
and
less
than
0.05
ppm
5­
OH­
MSO2.
Recoveries
from
fortified
tomato
samples
were
adequate;
recoveries
were
65­
86%
(
78.0
±
7.9%)
for
MSO
and
49­
77%
(
65.3
±
11.2%)
for
5­
OHMSO2
Residues
resulting
from
treatment
of
tomatoes
with
sethoxydim
ranged
from
0.60
to
1.06
ppm.

MRID
43801402
(
D219970,
L.
Cheng,
4/
9/
96)

The
study
was
conducted
to
update
the
tomato
residue
database.
Tomato
plants
were
treated
with
Poast
®
1.5
EC
at
a
rate
of
0.28
lb
ai/
A/
application
for
a
total
of
0.84
lb
ai/
A,
the
seasonal
maximum
rate.
Fruit
were
harvested
by
hand
according
to
the
label
PHI
of
20
days.

The
time
between
harvest
and
analysis
was
4­
5
months
(
5.5
months
max).
The
frozen
storage
stability
study
(
MRID
43801401)
submitted
with
the
field
trial
indicated
that
MSO
was
found
to
be
stable
in
corn
grain
and
forage,
lettuce,
oranges,
tomatoes,
cucumbers,
succulent
and
dry
beans,
potatoes,
onions,
apples,
cherries,
and
strawberries
for
5
years
under
frozen
conditions
and
5­
OH­
MSO2
was
stable
in
cherries,
strawberries,
and
tomatoes
for
3
years,
and
in
succulent
beans
and
potatoes
for
4
years
under
frozen
conditions.

Samples
were
analyzed
by
BASF
Analytical
Method
A9003.
Concurrent
recoveries
were
adequate;
recoveries
were
69­
78%
for
MSO
and
76­
85%
for
5­
OH­
MSO2.
Combined
residues
of
sethoxydim
and
its
metabolites
in
two
samples
of
tomatoes
were
0.45
and
1.14
ppm.

Peppers
MRID
43801406
(
D237724,
L.
Cheng,
7/
28/
97)

Studies
were
conducted
to
replace
existing
pepper
residue
data
generated
by
Craven
Laboratories.
Two
field
trials
on
peppers
were
conducted
in
CA.
Peppers
were
harvested
20
days
after
three
applications
of
the
1.5
lb/
gal
EC,
each
at
0.28
lb
ai/
A
(
1x
the
maximum
registered
rate).
Broadcast
applications
were
made
in
5
gal/
A
using
ground
equipment.

Samples
were
bagged
and
frozen
(
temperature
unspecified)
within
5.5
hours
of
collection.
Samples
were
stored
frozen
for
a
maximum
of
5.5
months
prior
to
analysis.
HED
noted
that
storage
stability
data
on
13
matrices
submitted
with
the
residue
data
on
tomatoes,
broccoli,
mustard
greens,
and
cabbage
(
D219970,
4/
9/
96,
L.
Cheng)
indicate
that
sethoxydim
and
metabolites
are
stable
for
3­
5
years.
Thus,
adequate
supporting
storage
stability
data
were
available
to
cover
the
storage
intervals
reflected
in
the
field
trials.

Samples
were
analyzed
by
GC/
FPD
Method
A9003.
Concurrent
recoveries
were
adequate;
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
61
of
101
recoveries
were
74.8
and
85.2%
for
MSO
and
82.7
and
92.2%
for
5­
OH­
MSO2.
Residues
in/
on
peppers
were
1.09­
2.26
ppm.

Vegetable,
leafy,
except
brassica,
group
4
The
Phase
IV
review
provided
limited
residue
data
from
crop
field
trials
conducted
on
leaf
lettuce,
head
lettuce,
celery,
and
spinach
in
support
of
a
tolerance
for
the
leafy
vegetable
(
except
brassica)
crop
group.
The
Phase
IV
indicated
that
no
data
gaps
existed.
The
leaf
lettuce
and
spinach
crop
field
trial
results
were
also
reported
in
a
6/
24/
92
EPA
memo
(
D172550,
M.
H.
Peters,
6/
24/
92).
Overall,
the
results
support
the
current
tolerance
level
of
4.0
ppm
for
crop
group
4.

Leaf
Lettuce
MRID
40375703
(
Summary
in
MRID
92166058)
(
D172550,
M.
H.
Peters,
6/
24/
92)

Crop
field
trials
of
leaf
lettuce
were
conducted
in
NJ,
OR,
WA,
FL,
AZ,
MA,
MI,
CA
(
3),
and
MN.
At
all
sites
except
two,
the
test
plots
received
two
applications
of
Poast
®
Herbicide
at
0.3
lb
ai/
A/
application
and
samples
were
collected
at
PHIs
of
13
to
18
days.
At
the
remaining
two
test
sites,
a
single
application
of
Poast
®
Herbicide
was
applied
at
a
rate
of
0.3
lb
ai/
A/
application
and
samples
were
collected
at
PHIs
of
36­
39
days.

Samples
were
analyzed
by
Method
30G.
Average
recoveries
of
sethoxydim,
MSO
and
5­
OHMSO2
ranged
from
81
to
83%.
Storage
stability
data
were
not
provided;
however,
HED
noted
that
existing
storage
stability
data
for
soybean
forage
were
translatable
to
these
field
trials.
Total
sethoxydim
residues
were
detected
in
the
leaf
lettuce
samples
at
a
maximum
of
<
0.86
ppm.

Spinach
MRID
40375704
(
Summary
in
MRID
92166060)
(
D172550,
M.
H.
Peters,
6/
24/
92)

Crop
field
trials
of
spinach
were
conducted
in
CA
(
5),
OK,
TN
(
2),
TX
(
3),
MS,
AR,
NJ
(
2),
NY,
WA,
and
CO.
Single
or
double
applications
of
Poast
®
Herbicide
were
applied
to
each
test
plot
at
a
rate
of
0.3
lb
ai/
A/
application.
Samples
were
collected
at
PHIs
of
10­
46
days.

Samples
were
analyzed
by
Method
30G.
Average
recoveries
of
sethoxydim,
MSO
and
5­
OHMSO2
ranged
from
87
to
90%.
Storage
stability
data
were
not
provided;
however,
HED
noted
that
existing
storage
stability
data
for
soybean
forage
were
translatable
to
these
field
trials.
Total
sethoxydim
residues
were
detected
in
spinach
samples
at
a
maximum
of
<
3.02
ppm.

Head
Lettuce
MRID
40375702
(
Summary
in
MRID
92166061)
(
L.
Cheng,
2/
25/
91)
Trials
were
conducted
in
major
lettuce
(
head)
growing
areas
using
ground
equipment
and
applying
sethoxydim
at
2
x
0.3
lb
ai/
A
(
label
maximum=
0.56
lb
ai/
A/
season).
Samples
were
collected
12­
31
days
(
label
PHI=
30
days)
and
total
sethoxydim
residues
were
less
than
1
ppm.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
62
of
101
Celery
MRID
40375701
(
Summary
in
MRID
92166059)
(
L.
Cheng,
2/
25/
91)

Trials
were
conducted
in
major
celery
growing
areas.
Sethoxydim
was
applied
at
2
x
0.3,
2
x
0.4
or
2
x
0.8
lb
ai/
A
(
label
maximum
of
2
x
0.28
lb
ai/
A/
season).
Samples
were
collected
at
PHIs
of
28­
33
days
(
label
PHI=
30
days)
and
total
sethoxydim
residues
were
less
than
1
ppm.

860.1520
Processed
Food
and
Feed
Alfalfa
MRID
No.
42816801
(
D192620,
F.
Suhre,
04/
19/
94)

The
registrant
submitted
data
from
a
processing
study
depicting
residues
of
sethoxydim
and
its
2­
cyclohexene­
1­
one
containing
metabolites
determined
as
DME
and
DME­
OH
in
alfalfa
hay
and
its
processed
commodity,
meal.
In
two
tests
conducted
in
WI
and
MT,
three
postemergence
broadcast
applications
of
the
1.5
lb/
gal
EC
formulation
were
made
at
0.5,
0.5,
and
0.3
lb
ai/
A
(
1.4x
the
maximum
seasonal
application
rate)
with
a
bicycle
or
backpack
sprayer
in
12.7­
16.2
gal/
A
of
finished
spray.
Alfalfa
was
harvested
14
days
after
the
final
treatment
and
cured
in
the
field
for
4­
5
days.

The
harvested
and
cured
hay
samples
were
processed
into
meal
using
a
simulated
industrial
procedure.
A
description
of
the
procedure
and
material
balance
sheets
were
included.
Samples
were
stored
frozen
at
<­
5
C
prior
to
analysis.
The
sample
storage
interval
between
harvest
of
alfalfa
hay
and
analysis
of
the
hay
was
13
months.
The
sample
storage
interval
between
harvest
of
the
alfalfa
hay
and
final
analysis
of
the
meal
was
approximately
14
months.
The
registrant
submitted
a
summary
of
storage
stability
data
for
weathered
alfalfa
hay
from
a
1983­
1984
study
to
support
the
current
study.
According
to
the
Sethoxydim
Phase
IV
review,
data
are
available
to
demonstrate
the
stability
of
sethoxydim
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety
in
several
commodities
(
including
alfalfa)
for
14
to
60
months
of
frozen
storage.
HED
concluded
that
adequate
storage
stability
data
were
available
to
support
the
alfalfa
processing
study
and
that
sufficient
levels
of
sethoxydim
residues
were
present
at
time
of
analysis
(
28
­
31
ppm
DME
and
1.4
­
2.7
ppm
DME­
OH)
to
determine
whether
concentration
would
result.

Duplicate
control
and
treated
samples
of
alfalfa
hay
and
meal
from
each
site
were
analyzed
for
sethoxydim
and
its
2­
cyclohexen­
1­
one
containing
metabolites,
determined
as
DME
and
DMEOH
using
BASF
Method
30H.
Samples
of
hay
and
meal
were
fortified
separately
with
5­
OHMSO2
and
MSO
at
0.5
and
50
ppm.
Recoveries
of
MSO
were
81%
and
123%
in
hay
and
76%
and
80%
in
meal,
and
recoveries
of
5­
OH­
MSO2
(
as
DME­
OH)
were
74%
and
138%
in
hay
and
78%
and
83%
in
meal.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
63
of
101
Combined
residues
of
sethoxydim
in/
on
alfalfa
hay
and
in
alfalfa
meal
were
30.4
­
33
ppm
and
29.5­
32.7
ppm,
respectively.
HED
concluded
that
the
study
indicates
that
the
residues
of
sethoxydim
and
its
metabolites
5­
OH­
MSO2
and
MSO
are
not
likely
to
concentrate
in
alfalfa
meal
processed
from
alfalfa
hay.

Apple
MRID
40576103
(
Summary
in
MRID
92166087)

Sethoxydim
is
currently
registered
for
use
on
pome
fruit.
The
registrant
submitted
an
apple
processing
study
that
consisted
of
an
apple
trial
conducted
at
an
exaggerated
rate
of
5x
and
a
PHI
of
14
days.
Samples
were
stored
frozen
a
maximum
of
4
months,
an
interval
covered
by
an
apple
storage
stability
study
showing
no
significant
decline
in
sethoxydim
residues
for
at
least
26
months.
Method
30G
was
used
to
analyze
total
sethoxydim
residues
in
all
samples.
The
total
combined
residues
in
the
unprocessed
apples
was
5.6
ppm.
Residues
in
apple
juice
and
wet
pomace
from
the
treated
apples
resulted
in
residue
levels
of
4.1
and
3.6
ppm,
respectively.
Hence
the
corresponding
processing
factors
in
apple
juice
and
wet
pomace
were
determined
to
be
0.7x
and
0.6x,
respectively.
Based
on
the
results
of
the
apple
processing
study,
HED
concludes
that
no
separate
tolerances
are
needed
for
apple
juice
or
wet
pomace.

Beet,
Sugar
MRID
No.
41966101
(
D167888,
D167906,
D167908,
W.
Wassell,
2/
19/
92)
MRID
No.
42839001
(
D182748,
D182746,
D182747,
D193019,
D193020,
D193021,
W.
Wassell,
8/
6/
93)

A
field
residue
study
was
conducted
in
North
Dakota
in
order
to
obtain
sugar
beet
roots
for
use
in
a
processing
study.
Poast
®
Herbicide
was
applied
twice
at
nominal
rates
of
2.0
lbs
ai/
A
by
ground
equipment
in
20
GPA.
This
rate
is
equivalent
to
4
times
the
maximum
application
rate.
The
interval
between
applications
was
29
days
and
samples
for
processing
were
harvested
28
days
after
the
last
application.
Samples
were
harvested
at
normal
maturity
and
were
received
at
the
processing
facility
5
days
after
harvest.
Samples
were
processed
into
refined
sugar,
dried
pulp,
and
molasses
using
simulated
commercial
procedures.

The
raw
beets
and
the
process
commodities
were
analyzed
according
to
BASF
Analytical
Method
30B
with
slight
modifications.
The
residues
are
quantitated
as
the
sethoxydim
metabolites
DME
and
DME­
OH
by
gas
chromatographic
analysis
utilizing
flame
photometric
detection
(
sulfur
mode).
A
limit
of
quantitation
for
each
analyte
of
0.05
ppm
sethoxydim
equivalents
was
specified.

Control
samples
(
sugar
beets,
dehydrated
pulp,
molasses
and
sugar)
were
fortified
with
MSO
and
5­
OH­
MSO
and
analyzed
concurrently
with
treated
and
untreated
samples.
Recoveries,
corrected
for
apparent
residue
levels
in
the
controls,
were
70­
106%
for
MSO
and
75­
116%
for
5­
OHMSO2

Total
residues
were
4.1­
4.6
ppm
in
sugar
beets,
1.6­
1.7
ppm
in
dehydrated
pulp,
31.2­
43.5
ppm
in
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
64
of
101
molasses
and
0.36
ppm
in
sugar
samples.
Residue
levels
in
the
treated
samples
were
not
corrected
for
apparent
residue
levels
in
control
samples
or
for
procedural
recoveries.
HED
noted
that
there
were
large
variation
of
the
residue
levels
between
the
duplicates
of
the
molasses
samples.
The
registrant
indicated
that
molasses
is
a
difficult
matrix
to
analyze
and
the
multistep
analytical
procedure
performed
may
have
caused
the
variable
residue
levels
in
the
duplicate
analyses.
HED
concluded
that
"
taking
into
account
the
variability
of
the
molasses
residue
values
and
the
fortification
recoveries
at
a
level
that
approximates
the
residue
levels
in
the
treated
samples
(
50
ppm
level
for
the
MSO
fortification),
residues
of
sethoxydim
appear
to
concentrate
in
the
molasses
processed
fraction
of
sugar
beets
at
a
factor
of
10x."
Accordingly,
as
the
sugar
beet
root
tolerance
level
is
1.0
ppm
the
appropriate
tolerance
level
for
sugar
beet
molasses
is
10
ppm.

Canola
MRID
42074202
(
D171714,
D171716,
D171724,
B.
Schneider,
9/
21/
92)

Sethoxydim
was
applied
at
an
4X
exaggerated
rate
(
two
applications
of
0.5
lb
ai/
A
+
1.0
qt/
A
crop
oil
concentrate)
by
a
postemergent
broadcast
ground
application
to
weeds
in
canola
cultivar
'
West
Star'
located
in
North
Dakota
with
a
PHI
of
61
days.
At
harvest,
canola
seed
were
stored
frozen
within
4
hours
and
shipped
to
the
Food
Protein
Research
and
Development
Center,
Texas
A&
M
University
for
processing.
The
processing
study
was
conducted
according
to
commercial
practice.
The
canola
seed
samples
were
processed
into
press
cake
(
meal),
soapstock,
crude
and
refined
oil
fractions.
The
optional
oil
bleaching
and
deodorizing
steps
were
not
utilized
in
the
study.

Processed
samples
were
then
stored
frozen
(­
5

C)
and
shipped
to
the
lab
for
analysis.
The
canola
seed
and
press
cake
samples
were
homogenized
and
mixed
with
dry
ice
and
finely
ground
and
then
stored
frozen
until
analysis.
The
residues
are
quantitated
as
the
sethoxydim
dimethyl
ester
metabolites,
DME
or
DME­
OH
by
gas
chromatography
utilizing
a
capillary
column
with
a
flame
photometric
detector.
The
detection
limits
for
canola
seed,
press
cake
(
meal),
and
soapstock
are
0.1
ppm,
while
the
detection
limit
for
crude
and
refined
oil
are
0.04
ppm.

Samples
(
press
cake,
soapstock,
and
crude
and
refined
oils)
were
analyzed
19
months
after
initial
storage
following
harvest.
No
storage
stability
data
were
submitted
for
this
crop;
however,
HED
concluded
that
storage
stability
data
developed
for
soybean
seed
(
non­
Craven
data)
were
adequate
and
translatable
to
canola.

Control
samples
for
each
matrix
were
also
fortified
at
levels
ranging
from
0.1
to
500
ppm
with
5­
OH­
MSO2
or
with
DME.
The
recoveries
of
5­
OH­
MSO2
ranged
from
73%
in
the
press
cake
to
116%
in
canola
seed
with
an
overall
average
of
86.2
±
13%;
whereas
the
recoveries
of
DME
ranged
from
61%
in
soapstock
to
125%
in
canola
seed
with
an
overall
average
of
85.1
±
17%.

Residue
levels
of
total
sethoxydim
equivalents
(
includes
DME
and
DME­
OH)
in
crude
and
refined
oil
were
76.4
ppm
and
3.1
ppm,
respectively;
whereas
the
press
cake
(
meal)
fractions
contained
131
ppm.
These
levels
were
compared
to
a
total
residue
level
of
116
ppm
in
canola
seeds.
Hence,
no
significant
concentration
of
residues
were
found
in
either
the
crude
or
refined
oil,
but
in
meal,
residues
concentrated
by
a
factor
of
1.13x.
Multiplying
the
rapeseed,
seed
tolerance
level
of
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
65
of
101
35
ppm
by
1.1x
supports
the
established
tolerance
level
of
40
ppm
for
rapeseed,
meal.

Citrus
MRID
40492605
(
Summary
in
MRID
92166086)

Sethoxydim
is
currently
registered
for
use
on
citrus
fruit.
The
registrant
submitted
an
orange
processing
study
that
consisted
of
an
orange
trial
conducted
at
an
exaggerated
rate
of
5x
and
a
PHI
of
11
days.
Samples
were
stored
frozen
a
maximum
of
18
months,
an
interval
covered
by
an
orange
storage
stability
study
showing
no
significant
decline
in
sethoxydim
residues
for
at
least
31
months.
Method
30G
was
used
to
analyze
total
sethoxydim
residues
in
all
samples.
The
total
combined
residues
in
the
unprocessed
oranges
was
0.22
ppm.
Residues
in
orange
juice,
oil,
and
dried
pulp
from
the
treated
oranges
resulted
in
residue
levels
of
<
0.20,
<
0.20,
and
0.60
ppm,
respectively.
Hence
the
corresponding
processing
factors
in
orange
juice,
oil,
and
dried
pulp
were
determined
to
be
<
1.0x,
<
1.0x,
and
2.7x,
respectively.

There
currently
are
tolerances
for
citrus,
dried
pulp
and
citrus,
molasses
at
1.5
ppm.
The
dried
pulp
tolerance
is
supported
by
the
available
data,
but
the
tolerance
for
citrus
molasses
should
be
revoked
as
the
commodity
is
not
listed
in
Table
1
of
OPPTS
860.1000.

Corn
(
Sethoxydim
Resistant)
MRID
#
43178702
(
D210060,
D210062,
D208310,
&
D208312,
M.
I.
Rodriguez,
7/
24/
95)

Two
sethoxydim­
resistant
(
SR)
field
corn
trials
were
conducted
in
Iowa
and
Illinois
and
the
corn
grain
collected
was
processed
and
analyzed
for
sethoxydim
residues.
Poast
®
Herbicide
was
applied
using
two
applications
of
0.5
lb
ai/
acre
each
for
a
total
of
1.0
lb
ai/
acre.
This
application
rate
represents
5X
the
maximum
label
rate
of
0.2
lb
ai/
acre
at
the
time
of
the
study
and
1.7X
the
current
maximum
rate
of
0.6
lb
ai/
acre
(
applied
as
two
applications
of
0.3
lb
ai/
acre
each).
Poast
®
was
applied
broadcast
post­
emergence
over­
the­
top
using
ground
equipment
at
the
3­
to
5­
leaf
stage
and
again
30
days
later
at
layby
(
not
less
than
30
inches
tall).
Field
corn
grain
was
harvested
at
normal
maturity;
PHIs
were
98
and
74
days
for
Iowa
and
Illinois,
respectively.
Field
corn
grain
harvested
was
processed
by
wet
and
dry
milling
into
crude
and
refined
oil,
starch,
grits,
meal,
and
flour.
The
petitioner
provided
flow
diagrams
as
well
as
a
description
of
the
wet
and
dry
milling
processes.
Both
processes
simulated
industrial
practices.

Field
corn
grain
samples
were
stored
frozen
at
<­
5
oC
until
analysis
or
processing.
The
frozen
field
corn
grain
samples
for
residue
analysis
were
finely
ground
in
a
chopper
and
aliquots
taken
for
analysis.
Processed
fractions
were
stored
at
<­
5
oC
until
analysis.
A
maximum
of
9
months
lapsed
between
harvest
and
analysis
of
the
processed
fraction
samples.
HED
noted
that
in
MRID
43178701,
storage
stability
for
sethoxydim
and
its
metabolites
in
field
corn
forage
and
grain
has
been
demonstrated
for
up
to
38
and
36
months,
respectively.
The
registrant
indicated
that
storage
stability
for
sethoxydim
and
its
metabolites
in
soybean
crude/
refined
oil
had
been
demonstrated
in
an
on­
going
study
for
up
to
19
months.
The
data
show
that
residues
in
field
corn
commodities
are
stable
during
freezer
storage
from
harvest
to
analysis.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
66
of
101
Crude
and
refined
oil
samples
were
analyzed
by
BASF
Method
30.
All
other
samples
were
analyzed
by
Analytical
Method
A9003.
For
both
methods,
the
limit
of
quantitation
for
each
analyte
is
0.05
ppm
of
sethoxydim
equivalents
or
0.1
ppm
for
the
total
residue.
Residues
were
determined
as
sethoxydim
equivalents.
Control
samples
were
fortified
with
MSO
and
5­
OHMSO2
for
recovery
analyses.
Method
recoveries
for
fortifications
of
0.05,
0.50,
and
1.0
ppm
for
grain,
grits,
starch,
meal,
flour,
refined
oil,
and
crude
oil
ranged
from
68
to
102%.

The
grain
from
Illinois
did
not
have
detectable
sethoxydim
residues
and
the
processed
fraction
samples
were
not
analyzed.
The
grain
from
Iowa
had
DME
residues
at
0.07
ppm
and
DME­
OH
residues
at
<
0.05
ppm
for
total
sethoxydim
residues
of

0.12
ppm.
Therefore,
field
corn
processed
fractions
from
Iowa
were
analyzed
for
sethoxydim
residues.

Wet­
milled
starch,
crude
oil,
and
refined
oil,
as
well
as
dry­
milled
grits,
meal,
flour
and
refined
oil
had
residues
of
<
0.05
ppm
for
each
analyte,
DME
and
DME­
OH.
Therefore,
total
residues
of
sethoxydim
in
these
samples
were
<
0.10
ppm.
Dry­
milled
grits
and
meal
had
calculated
residues
of
DME
below
the
quantitation
limit
at
0.03
and
0.02
ppm,
respectively.
Dry­
milled
crude
oil
had
DME
residues
of
0.08
ppm
and
DME­
OH
residues
of
<
0.05
ppm
for
total
sethoxydim
residues
of

0.13
ppm.
The
analysis
was
performed
in
triplicate
and
all
three
times
the
same
results
were
obtained.

Concentration
factors
in
all
cases
except
the
dry­
milled
crude
oil
were
less
than
one.
For
the
drymilled
crude
oil,
the
concentration
factor
was
1.08x.
HED
did
not
consider
this
to
demonstrate
concentration
due
to
the
very
low
residue
levels.
HED
noted
that
the
levels
reported
can
vary
depending
on
sample
preparation
and
the
ability
of
the
analytical
method
to
accurately
distinguish
between
the
levels
reported.

HED
concluded
that
sethoxydim
residues
do
not
concentrate
in
SR
field
corn
commodities.
Therefore,
no
tolerances
are
required
for
SR
field
corn
process
fractions.
HED
noted
that
these
results
coincide
with
previous
data
on
field
corn
(
non­
resistant)
processed
fractions.
In
PP#
9F3806
(
M.
I..
Rodríguez,
2/
27/
90,
DEB
#
s
5869/
5870,
MRID
#
s
412484­
01,
­
02,
­
03,
&
­
04),
a
trial
at
4X
the
application
rate
of
0.2
lb
ai/
A
provided
total
residues
that
did
not
exceed
the
limit
of
quantitation
of
0.01
ppm.

Cotton
MRID
00127281
(
Summary
in
92166078)
(
L.
Cheng,
2/
25/
91)

The
Phase
IV
review
indicated
that
the
cotton
processing
study
was
adequate
(
L.
Cheng,
2/
25/
91).
In
this
study
(
MRID
00127281)
cottonseeds
bearing
finite
sethoxydim
residues
were
processed
employing
small
scale
commercial
techniques
(
at
Texas
A
&
M).
The
hulls
were
removed,
the
meats
were
solvent
extracted
at
above
room
temperature,
and
the
oil
fraction
was
separated.
The
crude
oil
was
recovered
through
evaporation,
a
portion
of
which
was
refined
using
official
(
American
Oil
Chemists'
Society)
laboratory
methods
to
afford
refined
oil
and
soapstock
fractions.
The
extracted
flakes
(
from
meats)
were
air
dried
to
produce
the
meal
fraction.
Sethoxydim
was
found
to
concentrate
in
the
soapstock
fraction
(
2.6­
2.9x)
but
not
in
the
meal,
hulls,
crude
or
refined
oil
fraction.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
67
of
101
There
currently
is
a
tolerance
for
cotton,
seed,
soapstock;
however,
this
tolerance
is
not
needed
as
soapstock
is
not
listed
in
Table
1
of
OPPTS
860.1000.
The
cotton,
seed,
soapstock
tolerance
should
be
revoked.

Flax
No
MRID
number
(
D165411,
L.
Cheng,
9/
23/
91)

HED
noted
that
the
flax
processing
study
(
MRID
No.
00159591)
evaluated
in
the
Phase
IV
review
was
analyzed
by
Craven
Laboratories
and
indicated
that
the
soybean
processing
data
(
see
below)
could
be
used
as
surrogate
data
to
support
the
tolerance
for
flax
meal
(
D165411,
L.
Cheng,
9/
23/
91).
Because
the
soybean
processing
study
showed
no
residue
concentration
in
any
processed
commodity,
no
flax
meal
tolerance
is
needed.
Accordingly,
the
established
tolerance
level
of
7
ppm
for
flax,
meal
is
not
necessary
and
should
be
revoked.

Grapes
MRID
43801416
(
D237724,
L.
Cheng,
7/
28/
97)
(
Summary
in
92166088)

In
field
trials
conducted
in
CA,
grapes
received
two
applications
of
the
1.5
lb/
gal
EC
formulation
at
0.47
lb
ai/
A
(
1x)
applied
directly
to
the
foliage
and
fruit.
Grapes
were
harvested
14
days
after
the
second
application.
A
6x­
rate
trial
was
also
conducted,
but
the
first
(
1x)
trial
gave
sufficient
residues
for
processing.
Grapes
were
subjected
to
laboratory
simulations
of
commercial
juice
and
raisin
processing
procedures.
Grapes
and
processed
fractions
were
analyzed
within
10
months
of
grape
harvest.
Analyses
were
conducted
using
method
A9003.
Concurrent
recoveries
were
adequate
and
apparent
combined
residues
in
untreated
grapes,
raisins,
and
juice
were
<
0.1
ppm
(
nondetectable).

The
average
combined
residues
from
two
grape
samples
were
1.62
ppm.
This
level
was
considerably
higher
than
residues
in
grapes
from
the
other
grape
field
trials
(
HAFT
=
0.555
ppm).
The
report
explained
that,
for
the
processing
study,
application
was
made
directly
to
the
foliage
and
fruit,
whereas
in
the
residue
studies
application
was
directed
to
the
soil
at
the
base
of
the
vines
as
directed
on
the
labels.
Furthermore,
the
grapes
in
this
study
were
harvested
14
days
after
treatment,
whereas
the
50­
day
PHI
was
observed
in
the
residue
trials.

HED
concluded
that
sethoxydim
residues
concentrated

3x
in
raisins.
Applying
this
factor
to
the
HAFT
of
0.555
ppm
in
the
residue
field
trials
indicates
that
the
established
tolerance
of
2.0
ppm
is
appropriate.
Residues
did
not
concentrate
in
grape
juice
(
concentration
factor
=
0.6x).
Grape
pomace
and
raisin
waste
are
not
significant
livestock
feed
items;
therefore,
no
tolerances
for
these
commodities
are
needed.

Peanut
MRID
92166081
(
Summary
in
MRID
92166078)
(
L.
Cheng,
2/
25/
91)

The
Phase
IV
review
indicated
that
the
peanut
processing
study
was
adequate
(
L.
Cheng,
2/
25/
91).
In
this
study,
peanuts
were
processed
at
Texas
A
&
M.
Whole
peanuts
were
shelled
and
cooked.
After
drying
oil
was
pressed
out
of
the
kernels
to
afford
the
screwpress
cake
and
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
68
of
101
crude
oil
fractions.
The
cake
was
solvent
extracted
and
dried.
Crude
oil
was
refined
according
to
official
laboratory
methods
to
produce
refined
oil
fractions.
Results
show
no
concentration
in
peanut
oil
or
meal.
Therefore,
no
tolerances
are
needed
for
processed
peanut
commodities,
and
the
established
tolerance
for
peanut,
soapstock
should
be
revoked
as
it
is
not
a
significant
livestock
feedstuff.

Peppermint/
Spearmint
MRID
42101702
(
D172349,
W.
D.
Wassell,
2/
11/
92)

Two
field
trials
were
conducted
(
Oregon
and
Indiana)
during
1988
at
exaggerated
application
rates
to
produce
samples
for
a
mint
processing
study.
Mint
was
treated
with
two
applications
of
Poast
®
Herbicide
at
a
rate
of
2.0
lbs
al/
A
with
ground
equipment.
This
rate
is
equivalent
to
approximately
four
times
the
typical
rate.
In
both
trials,
mint
oil
and
spent
mint
hay
samples
were
collected
on
the
same
day
as
processing.
The
oil
was
distilled
from
the
mint
with
steam
and
the
spent
mint
hay
was
removed.

Green
plant
samples
were
analyzed
according
to
Method
30G.
Mint
hay
and
spent
mint
hay
samples
were
analyzed
according
to
Method
30H.
Mint
oil
samples
were
analyzed
according
to
Method
30
with
modifications.
The
limit
of
quantitation
for
each
analyte
was
1.0
ppm
for
the
green
plant,
2.0
ppm
for
the
hay
and
spent
hay,
and
0.5
ppm
for
the
oil.
Concurrent
recovery
data
were
adequate;
recoveries
of
5­
OH­
MSO2
ranged
from
63%
to
125%
in
mint
oil,
whereas
the
recoveries
of
MSO
ranged
from
63%
in
spent
hay
to
118%
in
mint
hay.

Residue
data
for
the
Indiana
trials
were
25.8
ppm,
27.1
ppm,
17.8
ppm
and
2.1
ppm
for
green
plant,
mint
hay,
spent
hay
and
mint
oil
respectively.
For
the
Oregon
trials,
residue
data
were
38.5
ppm,
52.3
ppm,
59.4
ppm
and
<
1.0
ppm
for
green
plant,
mint
hay,
spent
hay
and
mint
oil
respectively.
HED
concluded
that
the
Oregon
trial
was
not
valid
to
show
the
concentration
or
lack
of
concentration
of
residues
from
the
mint
hay
to
the
spent
mint
hay,
but
was
adequate
to
show
the
lack
of
concentration
from
the
processing
of
the
mint
hay
to
mint
oil
as
the
mint
hay
contained
detectable
residues
and
the
mint
oil
did
not.
HED
indicated
that
the
Indiana
trial
was
adequate
to
show
no
concentration
of
residues
in
both
the
mint
hay
and
oil.

HED
concludes
that
a
tolerance
for
residues
of
sethoxydim
in/
on
mint
oil
is
not
needed
as
the
RAC
tolerance
should
cover
any
residues
present
in
the
oil.

Potato
MRID
40195102
(
Summary
in
MRID
92166082)
(
L.
Cheng,
2/
25/
91)

The
Phase
IV
review
indicated
that
the
potato
processing
study
was
adequate
(
L.
Cheng,
2/
25/
91).
In
this
study,
potatoes
containing
2.8
ppm
total
residues
were
processed
at
a
facility
that
employed
small
scale
commercial
techniques.
For
chips,
fresh
potatoes
were
washed,
destoned,
peeled
(
abrasive
peeler),
sliced,
washed
and
fried.
Chips
were
then
de­
oiled
and
salted.
For
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
69
of
101
potato
flakes,
the
RAC
was
washed,
destoned,
steam
peeled,
scrubbed,
sliced,
washed
to
remove
starch
and
cooked
briefly.
After
cooling
the
potatoes
were
steamed
and
mashed.
Various
stabilizers
and
additives
were
introduced
and
the
resulting
mixture
was
dried
and
milled
to
the
proper
size.
In
the
granule
process,
after
the
step
in
which
the
various
additives
had
been
introduced,
the
mixture
was
divided
into
portions
and
stored
frozen.
From
these
was
prepared
the
"
add
back"
supply,
a
partially
finished
potato
granule
that
is
used
for
preparing
the
finished
granule.
One
aliquot
after
thawing
was
dried
on
a
fluid
bed
dryer
to
10%
water
level,
then
mixed
with
a
second
aliquot
and
the
resulting
mixture
was
brought
to
10%
moisture.
This
process
was
repeated
and
in
the
last
cycle
the
mass
was
dried
to
7­
7.5%
moisture
and
sifted
through
a
screen
for
final
packaging.
Residue
results
indicate
no
concentration
of
sethoxydim
in
wet
peels,
sliced/
peeled
potatoes
or
chips,
and
about
2x
concentration
in
dry
peels
(
stock
feed
granules),
flakes,
"
add
back"
potato
granules
and
potato
granules.
As
the
maximum
sethoxydim
residue
level
in
potato
RAC
from
the
field
trials
was
3
ppm,
a
tolerance
level
of
8
ppm
is
appropriate
for
"
potato,
granules/
flakes"
and
"
potato,
processed
potato
waste".

Safflower
MRID
44864501
(
D257559,
N.
Dodd,
1/
24/
02)

A
processing
study
on
safflower
was
submitted.
The
processed
commodities
from
safflower
seed
are
meal
and
refined
oil.
Residues
in
safflower
meal
and
oil
were
lower
than
in
the
seed,
indicating
that
sethoxydim
residues
do
not
concentrate
on
processing.
HED
concluded
that
pending
submission
of
storage
stability
data
on
oil,
tolerances
will
not
be
needed
for
meal
and
refined
oil
since
residues
in
these
processed
fractions
will
be
covered
under
the
RAC
tolerance.

Soybean
MRID
00100535
(
Summary
in
MRID
92166083)(
L.
Cheng,
2/
25/
91)

The
Phase
IV
review
indicated
that
the
soybean
processing
study
was
adequate
(
L.
Cheng,
2/
25/
91).
In
this
study,
soybeans
containing
41
ppm
total
residue
of
sethoxydim
and
its
metabolites
were
processed
by
commercial
techniques.
The
soybeans
were
heated,
cooled
and
cracked
at
which
time
the
hulls
were
removed.
The
seeds
were
flaked
and
solvent
extracted.
The
extracted
flakes
were
air
dried
to
afford
the
meal
fraction.
A
portion
of
the
crude
oil
recovered
from
solvent
evaporation
was
refined
according
to
official
laboratory
methods
to
yield
refined
oil
and
soapstock
fractions.
Results
indicate
no
concentration
of
sethoxydim
residues
in
any
of
the
processed
fractions.
Therefore
no
separate
tolerances
on
soybean
processed
fractions
are
warrented.

Sunflower
MRID
00131857
(
Summary
in
MRID
92166085)(
L.
Cheng,
2/
25/
91)

The
Phase
IV
review
indicated
that
the
sunflower
processing
study
was
adequate
(
L.
Cheng,
2/
25/
91).
Sunflower
seeds
bearing
2
or
3
ppm
sethoxydim
residues
were
hulled,
and
the
seeds
were
separated
from
the
hulls
(
Carver
shaker).
The
seeds
after
further
cleaning
were
solvent
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
70
of
101
extracted.
The
residue
was
dried
to
afford
the
meal.
Crude
oil
was
recovered
from
solvent
evaporation.
A
portion
was
processed
into
refined
oil
by
official
laboratory
methods.
Results
show
concentration
in
meal
(
1.3­
2.5x)
but
not
in
hulls,
crude
oil
or
refined
oil.
As
the
maximum
sunflower
seed
residue
level
was
5.8
ppm,
the
maximum
residue
level
expected
in
sunflower
meal
is
5.8
ppm
x
2.5
=
14.5
ppm.
Accordingly,
these
data
support
the
established
tolerance
level
of
20
ppm
for
sunflower,
meal.

Tomato
MRID
00162633
(
Summary
in
MRID
92166080)(
L.
Cheng,
2/
25/
91)

The
Phase
IV
review
indicated
that
the
tomato
processing
study
was
adequate
(
L.
Cheng,
2/
25/
91).
Tomatoes
containing
0.52
ppm
total
residue
of
sethoxydim
and
its
metabolites
were
processed
simulating
normal
commercial
process
as
defined
by
W.
A.
Gould's
"
Tomato
Production,
Processing,
and
Quality
Evaluation."
Tomatoes
after
homogenization
were
allowed
to
pass
through
a
sieve
and
a
cotton
cloth.
A
portion
of
the
filtrate
(
pulp
or
juice)
was
concentrated
until
the
percent
solids
reached
8.5%
to
afford
puree.
Another
portion
of
the
pulp
(
juice)
was
heated
and
then
the
following
ingredients
were
added:
glacial
acetic
acid,
sugar,
salt
and
starch
suspended
in
water.
Concentration
to
75%
of
the
original
pulp
weight
yielded
the
catsup
fraction.
The
residue
after
filtration
constituted
the
wet
pomace
which
upon
drying
to
92.5%
solids
afforded
the
dry
pomace.
The
results
showed
no
concentration
of
residues
in
tomato
juice
or
wet
pomace,
slight
concentration
in
puree
and
catsup
(
1.1­
1.2x),
and
2x
concentration
in
dry
pomace.
The
existing
tolerances
for
"
tomato,
dry
pomace"
and
"
tomato,
concentrated
products"
should
be
revoked
since
they
are
no
longer
considered
livestock
feedstuffs.
Additionally,
no
separate
tolerance
is
necessary
for
tomato,
puree
(
or
catsup)
since
the
concentration
factors
are
essentially
1x
in
these
processed
commodities.

860.1650
Submittal
of
Analytical
Reference
Standards
As
of
9/
02/
04,
analytical
reference
standards
for
sethoxydim
and
the
metabolites
MSO,
MSO2,
DME,
DME­
OH
and
5­
OH­
MSO2
are
available
at
the
EPA's
National
Pesticide
Standards
Repository.

860.1850
Confined
Accumulation
in
Rotational
Crops
The
registrant
submitted
a
confined
accumulation
study
(
Accession
No.
42825).
The
test
substance
was
(
butyrimidoyl­
1­
14C)­
sethoxydim
with
a
specific
activity
of
1.05
mCi/
mmol
and
a
radiopurity
of
98%.
A
soybean
plant
was
grown
in
each
of
4
pots
containing
sandy
loam
soil.
When
the
plants
had
reached
the
1­
2
trifoliolate
stage,
test
substance
was
applied
to
the
soil
surface
at
a
rate
of
0.45
lb.
ai/
A.
The
plants
were
then
grown
outdoors.
After
80
days,
the
soybeans
were
harvested.
The
soil
was
mixed
and
stored
outdoors
for
120
days.
The
soil
was
then
returned
to
the
pots
and
wheat
and
radishes
were
seeded.
Test
crops
were
then
grown
in
the
greenhouse.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
71
of
101
Crops
were
harvested
and
TRR
determined
by
combustion.
The
TRR
was
characterized
by
sequential
extractions.
The
only
data
reported
was
for
wheat
straw.
The
initial
extraction
was
with
50%
methanol/
water.
Analysis
indicated
that
62%
of
the
TRR
was
extractable,
while
38%
was
bound
residue.
The
aqueous
methanol
fraction
was
extracted
with
dichloromethane.
No
data
concerning
the
nature
of
these
residues
were
reported.
The
length
of
time
the
samples
were
stored
prior
to
analysis
was
not
reported
and
no
storage
stability
data
was
included.

This
study
does
not
meet
the
requirements
for
Good
Laboratory
Practice
Standards
as
it
was
performed
before
1989.
Only
two
test
crops
were
used,
crops
were
not
planted
at
30
and
365
DAT
intervals,
and
the
nature
of
the
residue
was
not
determined.
HED
concluded
that
the
results
of
this
study
were
thus
of
limited
value
in
determining
the
need
for
rotational
crop
tolerances
(
D189273,
G.
Kramer,
8/
3/
93).

860.1900
Field
Accumulation
in
Rotational
Crops
A
limited
field
study
using
soybeans
treated
with
14C­
ring­
labeled
sethoxydim
at
0.9
or
1.0
lb
ai/
A
(

1X
the
proposed
rate
on
safflower)
and
cotton
treated
at
0.5
lb
ai/
A
as
primary
crops
was
submitted
by
the
registrant
(
MRID
41510612).
At
approximately
30
days
after
treatment
(
simulating
emergency
replant),
immediately
after
harvest
of
the
primary
crop
(
simulating
fall
crop
rotations)
and
at
the
beginning
of
the
next
growing
season
(
simulating
annual
crop
rotations),
the
primary
crop
was
removed
from
the
plots
and
rotational
crops
were
planted.
The
selected
rotational
crops
represented
the
leafy
vegetable,
root
crop
and
small
grain
groups.

Total
radioactive
residues
(
TRRs)
were
<
0.005­
0.01
ppm
with
some
exceptions:
0.05
ppm
in
sorghum
forage
at
a
plantback
interval
of
30
days
(
0.5
lb
ai/
A
application
rate);
0.02
ppm
in
winter
wheat
forage
and
0.05
ppm
in
winter
wheat
straw
at
a
plantback
interval
of
134
days
(
1
lb
ai/
A
application
rate);
and
0.024
ppm
in
spring
wheat
grain
and
0.06
ppm
in
spring
wheat
straw
at
a
plantback
interval
of
283
days
(
0.5
lb
ai/
A
application
rate).

HED
noted
that
even
though
the
application
rate
in
cotton
was
below
the
maximum
for
this
crop,
it
was
similar
to
that
of
many
other
crops.
The
chance
that
using
the
highest
possible
application
rate
could
lead
to
rotational
crop
residues
in
excess
of
the
LOQ
is
judged
unlikely.
The
residues
in
this
study
were
measured
as
the
TRR
which
are
not
necessarily
the
sethoxydim
residues
detected
by
the
enforcement
analytical
method.
Studies
in
soybean
and
alfalfa
have
shown
that
approximately
60%
of
the
TRR
is
in
the
form
of
sethoxydim
metabolites.
Using
the
maximum
soybean
use
rate
(
0.71X
of
cotton),
the
highest
level
of
residues
observed
was
30­
60%
of
the
LOQ.
If
this
value
is
corrected
for
the
approximate
percentage
of
the
TRR
in
the
form
of
sethoxydim
metabolites
(
60%),
then
the
highest
residue
observed
was
only
18­
36%
of
the
LOQ.
High
levels
of
sethoxydim
residues
are
found
in
some
crops.
These
crops
are
typically
those
which
would
be
directly
treated
during
Poast
®
application
(
i.
e.,
alfalfa,
tolerance
of
40
ppm)
and
which
have
a
short
PHI
(
2­
4
weeks).
The
expected
residues
in
rotational
crops
would
be
similar
to
those
found
in
corn
grain.
Poast
®
is
applied
to
corn
no
higher
than
10
inches
up
the
stalk
with
the
corn
being
a
minimum
of
30
inches
in
height.
Residues
in
corn
grain
would
therefore
be
primarily
a
result
of
uptake
from
the
soil
as
are
residues
in
rotational
crops.
In
field
trials
with
0.8
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
72
of
101
lb.
ai/
A
sethoxydim,
the
residues
were
below
the
LOQ
(
0.1­
0.2
ppm)
in
field
corn
grain
(
PHI
of
51­
75
d)
and
sweet
corn
kernels
and
cobs
(
PHI
of
3­
24
d).
Sethoxydim
residues
in
rotational
crops
are
thus
expected
to
be
minimal.

Given
that
the
sethoxydim
residues
appear
to
be
below
the
LOQ
in
all
rotational
crops
at
all
plantback
intervals
and
that
tolerances
were
already
established
for
representatives
of
the
leafy
vegetable
and
root
crop
groups,
HED
concluded
that
no
tolerances
on
rotational
crop
are
required
for
plantback
times
greater
than
30
days.
In
addition,
HED
noted
that
the
label
prohibits
planting
crops
not
registered
for
the
product
for
120
days
after
application
(
D189273,
G.
Kramer,
8/
3/
93).
TOLERANCE
REASSESSMENT
SUMMARY
Tolerance
Reassessments
for
Sethoxydim
Tolerances
for
residues
of
sethoxydim
in/
on
plant
and
animal
commodities
are
expressed
in
terms
of
the
combined
residues
of
sethoxydim
[
2­[
1­(
ethoxyimino)
butyl]­
5­[
2­(
ethylthio)
propyl]­
3­
hydroxy­
2­
cyclohexen­
1­
one]
and
its
metabolites
containing
the
2­
cyclohexen­
1­
one
moiety,
calculated
as
sethoxydim.

A
summary
of
the
sethoxydim
tolerance
reassessments
is
presented
in
Table
11.

Tolerances
Listed
Under
40
CFR
§
180.412:

Adequate
residue
data
have
been
submitted
to
reassess
the
established
tolerances
for
sethoxydim
in/
on
the
listed
commodities.

TABLE
11.
Tolerance
Summary
for
Sethoxydim
Commodity
Established
Tolerance
(
ppm)
Recommended
Tolerance
(
ppm)
Comments
(
correct
commodity
definition)

Alfalfa,
Forage
40.0
40
Alfalfa,
Hay
40.0
40
Almond,
Hulls
2.0
2.0
Apple,
Dry
Pomace
0.8
0.80
Apple,
dried
pomace
Apple,
Wet
Pomace
0.8
­­­
Revoke:
not
a
significant
feedstuff
Apricot
0.2
0.20
Artichoke,
globe
5.0
5.0
Tolerance
with
Regional
Registration
Asparagus
4.0
4.0
Bean,
Dry,
Seed
20.0
20
Bean,
Forage
15.0
15
Cowpea,
forage
Bean,
Hay
50.0
50
Cowpea,
hay
Bean,
Succulent
15.0
15
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Commodity
Established
Tolerance
(
ppm)
Recommended
Tolerance
(
ppm)
Comments
(
correct
commodity
definition)

73
of
101
Beet,
Garden
1.0
1.0
Beet,
garden,
roots
Beet,
Sugar,
Molasses
10.0
10
Beet,
Sugar,
Roots
1.0
1.0
Beet,
Sugar,
Tops
3.0
3.0
Blueberry
4.0
4.0
Caneberry
Subgroup
13A
5.0
5.0
Caneberry
subgroup
13A
Canola/
rapeseed
35.0
35
Rapeseed,
seed
Canola/
rapeseed,
meal
40.0
40
Rapeseed,
meal
Carrot,
Roots
1.0
1.0
Carrot
Cattle,
Fat
0.2
0.20
Cattle,
Meat
0.2
0.20
Cattle,
Meat
Byproducts
1.0
1.0
Cherry,
Sweet
0.2
0.20
Cherry,
Tart
0.2
0.20
Citrus,
Dried
Pulp
1.5
1.5
Citrus,
Molasses
1.5
­­­
Revoke:
not
a
significant
feedstuff
Clover,
Forage
35.0
35
Clover,
Hay
50.0
55
The
maximum
residue
observed
was
50.7
ppm.

Coriander
4.0
4.0
Coriander,
leaves
Corn,
Field,
Grain
0.5
0.50
Corn,
Forage
2.0
2.0
Corn,
field,
forage
Corn,
Fodder
2.5
2.5
Corn,
field,
stover
Corn,
Sweet,
Forage
3.0
3.0
Corn,
Sweet,
Kernel
plus
Cob
with
Husks
Removed
0.4
0.40
Corn,
Sweet,
Stover
3.5
3.5
Cotton,
Seed,
Soapstock
15
­­­
Revoke:
not
a
significant
feedstuff
Cotton,
Undelinted
Seed
5.0
5.0
Cranberry
2.0
2.5
The
maximum
residue
observed
was
2.2
ppm.

Egg
2.0
2.0
Flax,
Meal
7
­­­
Revoke:
Covered
by
flax,
seed
tolerance
Flax,
Seed
5.0
5.0
Flax,
Straw
2.0
­­­
Revoke:
not
a
significant
feedstuff
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Commodity
Established
Tolerance
(
ppm)
Recommended
Tolerance
(
ppm)
Comments
(
correct
commodity
definition)

74
of
101
Fruit,
citrus
0.5
0.50
Fruit,
citrus,
group
10
Fruit,
Pome
0.2
0.20
Fruit,
pome,
group
11
Goat,
Fat
0.2
0.20
Goat,
Meat
0.2
0.20
Goat,
Meat
Byproducts
1.0
1.0
Grape
1.0
1.0
Grape,
Raisin
2.0
2.0
Hog,
Fat
0.2
0.20
Hog,
Meat
0.2
0.20
Hog,
Meat
Byproducts
1.0
1.0
Horse,
Fat
0.2
0.20
Horse,
Meat
0.2
0.20
Horse,
Meat
Byproducts
1.0
1.0
Horseradish
4.0
4.0
Juneberry
5.0
5.0
Lentil,
seed
30.0
30
Lingonberry
5.0
5.0
Milk
0.5
0.50
Nectarine
0.2
0.20
Peach
0.2
0.20
Peanut
25.0
25
Peanut,
Soapstock
75.0
­­­
Revoke:
not
a
significant
feedstuff
Pea,
Dry,
Seed
40.0
40
Pea,
Field,
Hay
40.0
40
Pea,
Field,
Vines
20.0
20
Pea,
field,
forage
Pea,
Succulent
10.0
10
Peppermint,
tops
(
stems
and
leaves
30.0
30
Peppermint,
tops
Pistachio
0.2
0.20
Potato,
Flakes
8.0
8.0
Combine
these
two
tolerances
into
the
following:
Potato,
granules/
flakes
Potato,
Granules
8.0
Potato
waste,
processed
(
wet
and
dry)
8.0
8.0
Potato,
processed
potato
waste
Poultry,
Fat
0.2
0.20
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Commodity
Established
Tolerance
(
ppm)
Recommended
Tolerance
(
ppm)
Comments
(
correct
commodity
definition)

75
of
101
Poultry,
Meat
0.2
0.20
Poultry,
Meat
Byproducts
2.0
2.0
Rhubarb
0.3
0.30
Tolerance
with
Regional
Registration
Safflower
15.0
15
Safflower,
seed
Two
additional
safflower
field
trials
are
needed
from
Region
10.

Salal
5.0
5.0
Sheep,
Fat
0.2
0.20
Sheep,
Meat
0.2
0.20
Sheep,
Meat
Byproducts
1.0
1.0
Soybean
16.0
16
Soybean,
seed
Soybean,
Hay
10.0
10
Spearmint,
tops
(
stems
and
leaves)
30.0
30
Spearmint,
tops
Strawberry
10.0
10
Sunflower,
Meal
20.0
20
Sunflower,
Seed
7.0
7.0
Tomato,
Concentrated
Products
24.0
­­­
Revoke:
not
a
significant
feedstuff
Tomato,
Dry
Pomace
12.0
­­­
Revoke:
not
a
significant
feedstuff
Tree
Nut
0.2
0.20
Nut,
tree,
group
14
Vegetable,
Brassica,
Leafy,
Group
5
5.0
5.0
Vegetable,
Bulb,
Group
3
1.0
1.0
Vegetable,
bulb,
group
3
Vegetable,
Cucurbit,
Group
9
4.0
4.0
Vegetable,
cucurbit,
group
9
Vegetable,
Fruiting,
Group
8
4.0
4.0
Vegetable,
fruiting,
group
8
Vegetable,
Leafy,
Except
Brassica,
Group
4
4.0
4.0
Vegetable,
leafy,
except
Brassica,
group
4
Tuberous
and
Corm
vegetable
crop
subgroup
4.0
4.0
Vegetable,
tuberous
and
corm,
subgroup
1C
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
76
of
101
Codex/
International
Harmonization
A
comparison
of
Canadian
and
Mexican
MRLs
with
recommended
US
tolerances
for
sethoxydim
is
provided
in
Table
12.
The
Canadian
tolerances
on
various
legume
vegetables
are
significantly
less
than
those
needed
to
cover
residues
in
the
U.
S.
The
Mexican
MRLs
are
based
on
the
U.
S.
tolerance
levels.

Table
12.
Comparison
of
Canadian
and
Mexican
MRLs
with
Recommended
US
Tolerances.

Crop
US
Tolerance
(
ppm)
Canada
MRL
(
ppm)
Mexico
MRL
(
ppm)

Alfalfa
(
hay
&
forage)
40
­­­
40
Pea,
dry
40
­­­
40
Lentils
30
30
30
Peanut
25
­­­
25
Tomato
paste
4
15
4
Soybean
16
5
16
Pea,
succulent
10
10
10
Bean,
dry
20
10
­­­

Strawberry
10
10
10
Sunflower
7
7
­­­

Brassica
vegetables
5
­­­
5
Cotton,
seed
5
­­­
5
Raspberry
5
5
­­­

Bean,
succulent
15
5
­­­

Curcurbit
vegetables
4
­­­
4
Fruiting
vegetables
4
­­­
4
Leafy
vegetables
4
­­­
4
Blueberry
4
4
­­­

Potato
4
4
4
Tomato
4
4
4
Artichoke
5
2
­­­

Cabbage
4
2
4
Cantaloupe
4
2
4
Cranberrry
2.5
2
­­­

Eggplant
4
2
4
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Crop
US
Tolerance
(
ppm)
Canada
MRL
(
ppm)
Mexico
MRL
(
ppm)

77
of
101
Mustard
4
2
4
Mustard
greens
4
2
4
Spinach
4
2
4
Celery
4
1
4
Cucumber
4
1
4
Lettuce
4
1
4
Pumpkin
4
1
4
Squash
4
1
4
Bulb
vegetables
1
 
1
Grape
1
 
1
Citrus
fruit
0.5
 
0.5
Asparagus
4
0.5
­­­

Broccoli
4
0.5
4
Corn
0.5
0.5
­­­

Pepper
4
0.5
4
Flax
5
0.2
­­­

Onion
1
0.2
1
Turnip
 
0.2
1
Apple
0.2
 
0.2
Carrot
1
0.1
 
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
78
of
101
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Sethoxydim
Summary
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D318169
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Unpublished
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BASF
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Poast
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2nd
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302
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[
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225
and
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Unpublished
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15
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162633
BASF
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(
1986)
Poast
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Herbicide­­
Fruiting
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PP
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3284:
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86:
[
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Unpublished
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70
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162812
Paulick,
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(
1985)
Determination
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263.
Unpublished
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prepared
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14
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162818
Craven,
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(
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Determination
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and
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No.
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2­
G­
309­
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31.
Unpublished
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20
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40195102
Paulick,
R.
(
1987)
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Potato
Process
Fractions:
BASF
Doc.
No.
87/
5009:
Report
No.
A8704.
Unpublished
study
prepared
by
BASF
Corp.
90
p.

40375701
Single,
Y.
(
1987)
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Celery:
BASF
Document
NO.
87/
5052.
Unpublished
study
prepared
by
BASF
Corp.
49
p.

40375702
Single,
Y.
(
1986)
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Head
Lettuce:
BASF
Document
No.
87/
5049.
Unpublished
study
prepared
by
BASF
Corp.
58
p.

40375703
Single,
Y.
(
1987)
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Leaf
Lettuce
and
Endive:
BASF
Document
No.
87/
5043.
Unpublished
study
prepared
by
BASF
Corp.
54
p.

40375704
Single,
Y.
(
1987)
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Spinach:
BASF
Document
No.
87/
5045.
Unpublished
study
prepared
by
BASF
Corp.
55
p.

40492601
Single,
Y.
(
1987)
Magnitude
of
the
Residue
of
Sethoxydim
&
Metabolites
in
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
80
of
101
Oranges:
Registration
Document
#
BASF:
87/
5072.
Unpublished
study
prepared
by
Nippon
Soda
Co.,
Ltd.
66
p.

40492602
Eswein,
R.
(
1987)
Magnitude
of
the
Residue
of
Sethoxydim
&
Metabolites
in
Lemons:
Registration
Document
#
BASF:
87/
5071.
Unpublished
study
prepared
by
Nippon
Soda
Co.,
Ltd.
47
p.

40492603
Eswein,
R.
(
1987)
Magnitude
of
the
Residue
of
Sethoxydim
&
Metabolites
in
Grapefruit:
Registration
Document
#
BASF:
87/
5070.
Unpublished
study
prepared
by
Nippon
Soda
Co.,
Ltd.
60
p.

40492604
Zehr,
R.
(
1987)
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Blueberries:
Registration
Document
#
BASF:
87/
5084.
Un­
published
study
prepared
by
Morse
Laboratories,
Inc.
in
cooperation
with
Nippon
Soda
Co.,
Ltd.
94
p.

40492605
Single,
Y.
(
1987)
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Orange
Process
Fractions:
Registration
Document
#
BASF:
87/
5078.
Unpublished
study
prepared
by
University
of
Florida.
54
p.

40515801
Morris,
W.
(
1987)
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Alfalfa
Forage
and
Hay
(
Aerial
vs.
Ground
Application):
Laboratory
Project
ID
87/
5023.
Unpublished
study
prepared
by
BASF
Corporation
Chemicals
Division.
58
p.

40576101
Single,
Y.
(
1987)
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Apples:
Registration
Document
#
BASF
87/
5086.
Unpublished
study
prepared
by
Nippon
Soda
Co.,
Ltd.
51
p.

40576102
Single,
Y.
(
1987)
Magnitude
of
the
Residue
of
Sethoxydin
and
Metabolites
in
Pears
and
Quince:
Registration
Document
#
BASF
87/
5087.
Unpublished
study
prepared
by
Nippon
Soda
Co.,
Ltd.
43
p.

40576103
Single,
Y.
(
1988)
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Apple
Process
Fractions:
Registration
Document
#
BASF
88/
5012.
Unpublished
study
prepared
by
Nippon
Soda
Co.,
Ltd.
53
p.

40639101
McAleese,
D.
(
1987)
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Sugarbeet
Roots
and
Tops:
Registration
Document
#
BASF
88/
5024.
Unpublished
study
prepared
by
Nippon
Soda
Co.
104
p.

40639102
Single,
Y.
(
1987)
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Sugarbeet
Roots:
Registration
Document
#
BASF
87/
5019.
Unpublished
study
prepared
by
Nippon
Soda
Co.,
Ltd.
54
p.

40783000
Citation:
BASF
Corp.
(
1988)
Submission
of
Chemistry
Data
in
Support
of
the
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
81
of
101
Full
Tolerance
Petition
and
Application
for
Registration
of
Poast
®
Herbicide
(
Sethoxydim).
Transmittal
of
2
studies.

40783001
Single,
Y.
(
1988)
Magnitude
of
the
Residue
of
Sethoxydim
and
Its
Metabolites
in
Green
and
Bulb
Onions:
Registration
Document
No.
BASF:
88/
5029.
Unpublished
study
prepared
by
Nippon
Soda
Co.,
Ltd.
76
p.

40783002
Single,
Y.
(
1988)
Magnitude
of
the
Residue
of
Sethoxydim
and
Its
Metabolites
in
Garlic:
Registration
Document
#
BASF:
88/
5027.
Unpublished
study
prepared
by
Nippon
Soda
Co.,
Ltd.
38
p.

41072001
Baron,
J.
(
1989)
Sethoxydim:
Magnitude
of
Residue
on
Rhubarb:
IR­
4
PR
No.
2438.
Unpublished
study
prepared
by
IR­
4
North
Central
Region
Analytical
Laboratory.
44
p.

41236401
Single,
Y.
(
1988)
Magnitude
of
the
Residues
of
Sethoxydim
and
Its
Metabolites
on
Sweet
and
Sour
Cherries:
Project
ID
88/
5065.
Unpublished
study
prepared
by
Nippon
Soda.,
Ltd.
44
p.

41236402
Single,
Y.
(
1988)
Magnitude
of
the
Residue
of
Sethoxydim
and
Its
Metabolites
in
Peaches:
Project
ID
88/
5064.
Unpublished
study
prepared
by
Nippon
Soda.,
Ltd.
43
p.

41236403
Single,
Y.
(
1988)
Magnitude
of
the
Residues
of
Sethoxydim
and
Its
Metabolites
in
Plums:
Project
ID
88/
5066.
Unpublished
study
prepared
by
Nippon
Soda.,
Ltd.
34
p.

41236404
Single,
Y.
(
1988)
Magnitude
of
the
Residues
of
Sethoxydim
and
Its
Metabolites
in
Apricots
and
Nectarines:
Project
ID
88/
5067.
Unpublished
study
prepared
by
Nippon
Soda.,
Ltd.
33
p.

41248401
Single,
Y.
(
1988)
Magnitude
of
the
Residues
of
Sethoxydim
and
Its
Metabolites
in
Field
Corn:
Project
ID
88/
5143.
Unpublished
study
prepared
by
Nippon
Soda,
Ltd.
133
p.

41248402
Burkey,
J.
(
1988)
Magnitude
of
the
Residue
of
Sethoxydim
and
Its
Metabolites
in
Field
Corn
Grain
Processed
Fractions:
Project
ID
88/
5144.
Unpublished
study
prepared
by
BASF
Corp.,
Chemical
Div.
102
p.

41248403
Single,
Y.
(
1988)
Magnitude
of
the
Residues
of
Sethoxydim
and
Its
Metabolites
in
Sweet
Corn
and
Sweet
Corn
Cannery
Waste:
Project
ID
88/
5107.
Unpublished
study
prepared
by
Nippon
Soda,
Ltd.
64
p.

41428501
Single,
Y.
(
1988)
Magnitude
of
the
Residues
of
Sethoxydim
and
its
Metabolites
in
Almond
Nuts
and
Hulls:
Lab
Project
Number:
A8813.
Unpublished
study
prepared
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
82
of
101
by
Nippon
Soda.,
Ltd.
46
p.

41475202
Nomura,
O.;
Nakashima,
N.
(
1987)
Sethoxydim:
Octanol/
Water
Partition
Coeffecient:
Final
Report.
Lab
Project
Number:
BASF
87/
0377
Nisso
EC­
98.
Unpublished
study
prepared
by
Nippon
Soda
Co.
Ltd.,
Environmental
Toxicology
Laboratory.
17
p.
­
NOT
REVIEWED
41475201
Nomura,
O.;
Nakashima,
N.
(
1987)
Sethoxydim­­
Water
Solubility:
Final
Report:
Lab
Project
Number:
BASF
87/
0376:
NISSO
EC­
97.
Unpublished
study
prepared
by
Nippon
Soda
Co.,
Ltd.,
Environ­
mental
Toxicology
Laboratory.
16
p.­
NOT
REVIEWED
41510601
Nomura,
O.
(
1979)
Sethoxydim­­
Solubility
in
Solvents:
Lab
Project
Number:
BASF
89­
5161;
NISSO
EC
202.
Unpublished
study
prepared
by
Nippon
Soda
Co.,
Ltd.
9
p.
­
NOT
REVIEWED
41428503
Single,
Y.
(
1988)
Magnitude
of
the
Residues
of
Sethoxydim
and
Its
Metabolites
in
Walnuts:
Lab
Project
Number:
A8814.
Unpublished
study
prepared
by
Nippon
Soda.,
Ltd.
37
p.

41510612
Clark,
J.
;
Adamson,
S.
(
1981)
Uptake
of
BAS
9052­
Carbon
14
(
NP­
55)
Residues
by
Rotational
Crops
Under
Field
Conditions:
Lab
Project
Number:
PM­
33:
81­
5053.
Unpublished
study
prepared
by
BASF
Corp.
20
p.

41607203
Sanson,
C.
A.
(
1990)
Data
Concerning
the
Physical
and
Chemical
Characteristics
of
the
Technical
Grade
of
Active
Ingredient
of
Poast
®
Herbicide.
Unpublished
study
submitted
by
BASF
Corporation.
50
p.

41627001
Baron,
J.
(
1990)
Sethoxydim:
Magnitude
of
Residue
on
Cranberry:
Lab
Project
Number:
IR/
4/
2132.
Unpublished
study
prepared
by
Morse
Laboratories.
167
p.

41966101
Single,
Y.
(
1990)
Magnitude
of
the
Residue
of
Sethoxydim
(
BAS
9052
H)
and
Metabolites
in
Sugar
Beet
Process
Fractions:
Lab
Project
Number:
A9010.
Unpublished
study
prepared
by
BASF
Corp.
80
p.

41980701
Sears,
L.
(
1987)
Investigation
of
Multiresidue
Pesticide
Analytical
Methodologies
for
the
Determination
of
Sethoxydim
and
Its
Metabolites:
Lab
Project
Number:
87/
5128.
Unpublished
study
prepared
by
BASF
Corp.
41
p.

42074201
Sotack,
G.
(
1991)
Magnitude
of
the
Residue
of
Sethoxydim
and
its
Metabolites
in
Canola
Forage
and
Seeds
(
Raw
Agricultural
Commodity)
Lab
Project
Number:
91/
5129.
Unpublished
study
prepared
by
ADPEN
Labs.
175
p.

42074202
Sotack,
G.
(
1991)
Magnitude
of
the
Residues
of
Sethoxydim
(
BAS
9052
H),
the
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
83
of
101
Active
in
Poast
®
Herbicide,
and
its
Metabolites
in
Canola
Process
Fractions:
Lab
Project
Number:
91/
5110.
Unpublished
study
prepared
by
BASF
Corp.
102
p.

42101701
Burkey,
J.
(
1991)
Magnitude
of
the
Residue
of
Sethoxydim,
the
Active
Ingredient
in
Poast
®
Herbicide,
and
its
Metabolites
in
Mint­
Green
Plant
and
Hay:
Lab
Project
Number:
91/
5111;
A9116.
Unpublished
study
prepared
by
Huntingdon
Analytical
Services
(
HAS).
163
p.

42101702
Sotack,
G.
(
1991)
Magnitude
of
the
Residue
of
Sethoxydim
(
BAS
9052
H),
the
Active
Ingredient
in
Poast
®
Herbicide,
and
its
Metabolites
in
Mint
Process
Fractions
(
Green
Plant,
Mint
Hay,
Spent
Hay
and
Oil):
Lab
Project
Number:
A9108:
91/
5103.
Unpublished
study
prepared
by
BASF
Corp.
111
p.

42195001
Biehn,
W.
(
1991)
Sethoxydim:
Magnitude
of
the
Residue
on
Carrot:
Lab
Project
Number:
2046:
9052
6H/
28.
Unpublished
study
prepared
by
IR­
4
Northeastern
Region
Analytical
Lab.
209
p.

42353601
Sotack,
G.
(
1991)
Magnitude
of
the
Residue
of
Sethoxydim,
the
Active
Ingredient
in
Poast
®
Herbicide,
and
its
Metabolites
in
Clover
Forage
and
Hay:
Lab
Project
Number:
91/
5236:
A9120.
Unpublished
study
prepared
by
Adpen
Labs
and
Stewart
Ag
Research
Services,
Inc.
281
p.

42487401
Sotack,
G.
(
1991)
Magnitude
of
the
Residue
of
Sethoxydim
and
its
Metabolites
in
Asparagus
Spears
(
Raw
Agricultural
Commodities):
Lab
Project
Number:
91/
5242.
Unpublished
study
prepared
by
McKenzie
Labs.
161
p.

42487402
Biehn,
W.
(
1992)
Sethoxydim:
Magnitude
of
the
Residue
on
Asparagus­­
1988
Trials:
Lab
Project
Number:
IR­
4
PR
2202,
4009:
Unpublished
study
prepared
by
IR­
4
Northeastern
Region
Analytical
Lab
(
Cornell
Univ).
84
p.

42816801
Sotack,
G.
S.
(
1993)
Magnitude
of
the
Residue
of
Sethoxydim
and
Its
Metabolites
in
1991
Alfalfa
Hay
Processed
Fraction
Samples.
BASF
Registration
Document
No.
93/
5046,
Report
No.
A9218.
Unpublished
study
submitted
by
BASF
Corporation,
Research
Triangle
Park,
NC.
102
p.

42834201
Sotack,
G.
(
1991)
Magnitude
of
the
Residue
of
Sethoxydim
and
its
Metabolites
in
Asparagus
Spears
(
Row
Agricultural
Commodity):
Supplemental
Information:
Lab
Project
Number:
91/
5242:
A9121.
Unpublished
study
prepared
by
McKenzie
Labs.
7
p.

42834202
Biehn,
W.
(
1992)
Sethoxydim:
Magnitude
of
Residue
on
Asparagus­­
1988
Trials:
Supplemental
Information:
Lab
Project
Number:
2202,
4009.
Unpublished
study
prepared
by
IR­
4
Northeastern
Region
Analytical
Lab.
8
p.

42834201
Sotack,
G.
(
1991)
Magnitude
of
the
Residue
of
Sethoxydim
and
its
Metabolites
in
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
84
of
101
Asparagus
Spears
(
Row
Agricultural
Commodity):
Supplemental
Information:
Lab
Project
Number:
91/
5242:
A9121.
Unpublished
study
prepared
by
McKenzie
Labs.
7
p.

42834202
Biehn,
W.
(
1992)
Sethoxydim:
Magnitude
of
Residue
on
Asparagus­­
1988
Trials:
Supplemental
Information:
Lab
Project
Number:
2202,
4009.
Unpublished
study
prepared
by
IR­
4
Northeastern
Region
Analytical
Lab.
8
p.

42839001
Sotack,
G.
(
1993)
Magnitude
of
the
Residue
of
Sethoxydim
(
BAS
9052
H)
and
Metabolites
in
Sugar
Beet
Process
Fractions
(
Amended
June
18,
1993):
Lab
Project
Number:
90/
5121:
A9010A:
A9021.
Unpublished
study
prepared
by
BASF
Corp.
91
p.

43051701
Biehn,
W.
(
1992)
Sethoxydim:
Magnitude
of
Residue
on
Asparagus­­
1988
Trials:
Supplemental
Information:
Lab
Project
Number:
2202:
4009.
Unpublished
study
prepared
by
IR­
4
Northeastern
Region
Analytical
Lab.
26
p.

43062201
Jordan,
J.
(
1993)
Magnitude
of
Sethoxydim
Residue
in
Tomato:
Lab
Project
Number:
93/
3161:
A9301:
FR9210.
Unpublished
study
prepared
by
Huntington
Analytical
Services.
116
p.

43062202
Jordan,
J.
(
1993)
Magnitude
of
Sethoxydim
Residues
in
Summer
Squash:
Lab
Project
Number:
93/
5162:
A9302:
92076.
Unpublished
study
prepared
by
Huntington
Analytical
Services.
171
p.

43062203
Jordan,
J.
(
1993)
Magnitude
of
Sethoxydim
Residues
in
Cantaloupe:
Lab
Project
Number:
93/
5163:
A9304:
FR9210.
Unpublished
study
prepared
by
Huntington
Analytical
Services.
140
p.

43062205
Jordan,
J.
(
1993)
Magnitude
of
Sethoxydim
Residue
in
Cotton:
Lab
Project
Number:
93/
5167:
A9346:
HAS
A008.032.
Unpublished
study
prepared
by
Huntington
Analytical
Services.
162
p.

43144501
Panek,
E.
(
1994)
Metabolism
and
Distribution
of
(
carbon
14)­
Sethoxydim
in
Sugar
Beets:
Final
Report:
Lab
Project
Number:
91129:
M9405:
94/
5009.
Unpublished
study
prepared
by
BASF
Agricultural
Research
Center,
Battelle
Columbus
Operations,
and
Nisso
Chemical
Analysis
Service.
349
p.

43178701
Jordan,
J.
(
1994)
Magnitude
of
the
Residue
of
Sethoxydim
and
Its
Metabolites
in
Sethoxydim
Resistant
Field
Corn:
Lab
Project
Number:
A9325A:
92031:
94/
5007.
Unpublished
study
prepared
by
Stewart
Agric.
Research
Services;
Land
O'
Lakes,
Inc.;
Agri­
Research
Corp.
265
p.

43178702
Jordan,
J.
(
1993)
Magnitude
of
Sethoxydim
Residues
in
Sethoxydim
Resistant
Corn
Processed
Fractions:
Lab
Project
Number:
A9342:
94/
5006:
ER92071.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
85
of
101
Unpublished
study
prepared
by
Stewart
Agric.
Research
Services;
Land
O'
Lakes,
Inc.;
Agri­
Research
Corp.;
Agvise
Lab.
Inc.;
Nisso
Chemical
Analysis
Service.
134
p.

43223401
Sotack,
G.
(
1994)
Storage
Stability
of
Sethoxydim
Metabolites
in
Animal
Matrices
(
Milk,
Eggs,
Beef,
Chicken,
Beef
Liver,
and
Beef
Kidney):
Lab
Project
Number:
A9408:
91127:
94/
5044.
Unpublished
study
prepared
by
BASF
Corp.
116
p.

43282401
Jordan,
J.
(
1994)
Magnitude
of
Sethoxydim
Residues
in
Cucumber:
Lab
Project
Number:
A9414:
94/
5052:
92058.
Unpublished
study
prepared
by
Huntingdon
Analytical
Services
in
cooperation
with
Stewart
Agricultural
Research
Services,
Inc.
and
Field
Cooperators.
168
p.

43455701
Jordan,
J.
(
1994)
Magnitude
of
Residue
of
Sethoxydim
and
Its
Metabolites
in
Sethoxydim
Resistant
Field
Corn:
1993
Field
Project:
Lab
Project
Numbers:
94/
5160:
A9435:
ER93054.
Unpublished
study
prepared
by
Huntingdon
Analytical
Services;
Stewart
Agricultural
Research
Services;
and
AGVISE
Labs.,
Inc.
246
p.

43467001
Ishihara,
K.
(
1994)
LC­
MS
Re­
Analysis
of
M­
SO2
Isolated
from
Sugar
Beet:
Lab
Project
Number:
94/
5004:
BASF/
94/
5004:
NISSO/
2/
139/
EC/
590.
Unpublished
study
prepared
by
NISSO
Chemical
Analysis
Service
Co.,
Ltd.
13
p.

43801401
Burkey,
J.;
Riley,
M.
(
1995)
Freezer
Storage
Stability
of
Sethoxydim
Metabolites
MSO
and
5­
OH­
MSO2
in
Representative
Fruit
and
Vegetable
Crops:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
95/
5145:
A9442:
A8906.
Unpublished
study
prepared
by
BASF
Corp.
111
p.

43801402
Wofford,
J.;
Hess,
E.
(
1995)
Magnitude
of
Sethoxydim
Residue
in
Tomatoes:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
95/
5088:
A9535:
94055.
Unpublished
study
prepared
by
BASF
Corp.
102
p.

43801403
Wofford,
J.;
Hess,
E.
(
1995)
Magnitude
of
Sethoxydim
Residue
in
Broccoli:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
95/
5091:
A9534:
94057.
Unpublished
study
prepared
by
BASF
Corp.
130
p.

43801404
Wofford,
J.;
Hess,
E.
(
1995)
Magnitude
of
Sethoxydim
Residue
in
Mustard
Greens:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
95/
5092:
A9531:
94061.
Unpublished
study
prepared
by
BASF
Corp.
116
p.

43801405
Hess,
E.
(
1995)
Magnitude
of
Sethoxydim
Residue
in
Cabbage:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
86
of
101
95/
5093:
A9540:
94040.
Unpublished
study
prepared
by
BASF
Corp.
200
p.

43801406
Wofford,
J.;
Hess,
E.
(
1995)
Magnitude
of
Sethoxydim
Residue
in
Peppers:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
95/
5097:
A9537:
94056.
Unpublished
study
prepared
by
BASF
Corp.
101
p.

43801407
Hess,
E.
(
1995)
Magnitude
of
Sethoxydim
Residue
in
Potatoes:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
95/
5098:
A9536:
94045.
Unpublished
study
prepared
by
BASF
Corp.
207
p.

43801408
Hess,
E.
(
1995)
Magnitude
of
Sethoxydim
Residue
in
Peanut:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
95/
5100:
A9549:
94043.
Unpublished
study
prepared
by
BASF
Corp.
139
p.

43801409
Hess,
E.
(
1995)
Magnitude
of
Sethoxydim
Residue
in
Flax:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
95/
5101:
A9548:
94041.
Unpublished
study
prepared
by
BASF
Corp.
130
p.

43801410
Hess,
E.
(
1995)
Magnitude
of
Sethoxydim
Residue
in
Grapes:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
95/
5139:
A9552:
94042.
Unpublished
study
prepared
by
BASF
Corp.
169
p.

43801411
Hess,
E.
(
1995)
Magnitude
of
Sethoxydim
Residue
in
Succulent
Beans:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
95/
5140:
A9557:
94039.
Unpublished
study
prepared
by
BASF
Corp.
286
p.

43801412
Wofford,
J.;
Hess,
E.
(
1995)
Magnitude
of
Sethoxydim
Residue
in
Soybeans:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
95/
5141:
A9550:
94060.
Unpublished
study
prepared
by
BASF
Corp.
176
p.

43801413
Wofford,
J.;
Hess,
E.
(
1995)
Magnitude
of
Sethoxydim
Residue
in
Dry
Beans:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
95/
5142:
A9556:
94058.
Unpublished
study
prepared
by
BASF
Corp.
206
p.

43801414
Wofford,
J.;
Hess,
E.
(
1995)
Magnitude
of
Sethoxydim
Residue
in
Dry
Peas:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
95/
5143:
A9553:
94059.
Unpublished
study
prepared
by
BASF
Corp.
136
p.

43801415
Hess,
E.
(
1995)
Magnitude
of
Sethoxydim
Residue
in
Succulent
Peas:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
87
of
101
Number:
95/
5144:
A9551:
94044.
Unpublished
study
prepared
by
BASF
Corp.
212
p.

43801416
Hess,
E.;
Bardinelli,
T.
(
1995)
Magnitude
of
Sethoxydim
Residue
in
Grape
Processed
Fractions:
(
Data
Submitted
as
Alternate
to
Craven
Laboratories
Generated
Data):
Lab
Project
Number:
95/
5138:
A9555:
94046.
Unpublished
study
prepared
by
BASF
Corp.
185
p.

43973101
Kunkel,
D.
(
1996)
Sethoxydim:
Magnitude
of
the
Residue
on
Artichoke:
(
Data
submitted
as
alternate
to
Craven
Laboratories
generated
data):
Lab
Project
Number:
6102.92­
NYR01:
PR
6102:
6102.92­
CA23.
Unpublished
study
prepared
by
IR­
4.
210
p.

43972701
Kunkel,
D.
(
1996)
Sethoxydim:
Magnitude
of
the
Residue
on
Raspberry:
(
Data
submitted
as
alternate
to
Craven
Laboratories
generated
data):
Lab
Project
Number:
5729.94­
NYR17:
PR
5729:
5729.94­
OR28.
Unpublished
study
prepared
by
IR­
4.
233
p.

44864501
Biehn,
W.
L.
(
1999)
Sethoxydim:
Magnitude
of
Residue
on
Safflower,
IR­
4
Project
No.
2531.
Unpublished
study
sponsored
by
IR­
4.
367
pp.

45100501
Burkey,
J.;
Versoi,
P.
(
2000)
The
Magnitude
of
Sethoxydim
Residues
in
Sethoxydim­
Resistant
Sweet
Corn.
BASF
Registration
Document
No.:
2000/
5093.
BASF
Study
Number:
97020.
Unpublished
study
prepared
by
BASF
Corporation.
226
p.

92166042
McKenna,
E.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
00131857
and
Related
MRIDs
41510615.
Sethoxydim:
Nature
of
Residues
in
Sugar
Beets:
REG
DOC
#
BASF
90/
6096,
#
80/
9003;
BWC
Report
No.
1947
(
83/
9000)
and
RD­
8019
(
83/
9003).
Prepared
by
BASF
AKTIENGESELLSCHAFT.
22
p.

92166044
Soeda,
Y.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
00153602.
Sethoxydim
­
Nature
of
the
Residue
in
Alfalfa:
Project:
RD­
8482N,
RD­
8483
and
M9002;
REG
DOC
#
BASF
90/
6047,
84/
5024
and
90/
5019.
Prepared
by
NIPPON
SODA
CO.
LTD.
11
p.

92166046
Bornemann,
V.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
00153602
and
Related
MRIDs
00155129.
Biokinetics
and
Metabolism
of
Sethoxydim
Sulfoxide
in
Goats:
BASF
Reports
HRC
BSF
415/
84781,
2092,
and
LC
1069:
REG
DOC
#
BASF
90/
6094.
Prepared
by
HUNTINGDON
RESEARCH
CENTRE
LTD.
36
p.

92166047
Kohl,
W.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
00153602
and
Related
MRIDs
00155129.
Biokinetics
and
Metabolism
of
(
Carbon­
14)­
Sethoxydim
in
Laying
Hens:
BAASF
Reports
BSF
416,
2101,
1068,
BSF
447
and
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
88
of
101
1070.
Prepared
by
BASF
Aktiengesellschaft.
20
p.

92166049
Eswein,
R.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
00100535
and
Related
MRIDs
00153602,
00042808.
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Chicken
Tissues
and
Eggs:
BASF
Report
No.
PR­
205
and
Huntingdon
Analytical
Services
Report
BSF
420BR/
841030;
Magnitude
of
the
Residue...
in
Beef
Tissues
and
Milk:
Report
No.
PR­
254;...
BASF
Report
No.
PR­
200.
Prepared
by
PRODUCT
SAFETY
LABS.
27
p.

92166055
Burkey,
J.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
00162812
and
Related
MRIDs
00162813,
00162815,
00162816,
00162817,
40195103,
00162633.
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Cucurbits;
Freezer
Storage
Stability
of
Sethoxyim
(
sic)
Metabolites
MSO
and
5­
OH­
MSO2
in
Potatoes;
The
Freezer
Storage
Stability
of
Sethoxydim
Metabolites
MSO
and
5­
OH­
MSO2
in
Tomatoe
Samples:
REG
DOC
#
BASF
90/
6073.
Prepared
by
BASF
WYANDOTTE
CORP.
16
p.

92166057
Burkey,
J.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
00148007
and
Related
MRIDs
00162633.
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Fruiting
Vegetables;
The
Freezer
Storage
Stability
of
Sethoxydim
Metabolites
MSO
and
5­
OH­
MSO2
in
Tomato
Samples:
REG
DOC
#
BASF
90/
6061
BASF
Report
Nos.
CR­
16A,
PR­
257,
CR­
16C,
CR­
16B,
PR­
258
and
SR­
118.
Prepared
by
BASF
AKTIENGESELLSCHAFT.
17
p.

92166058
Jordan,
R.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
40375703
and
Related
MRIDs
40611405,
00130578.
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Leaf
Lettuce;
Freezer
Storage
Stability
of
Sethoxydim
and
Its
Metabolites
in
Legume
Vegetables;
Freezer
Storage
Stability
of
BAS
9052
H
and
MSO,
Its
Metabolite,
in
Soybean
Forage:
REG
DOC
#
BASF
90/
6066;
BASF
Report
Nos.
A8730,
A8736
and
SR­
79.
Prepared
by
NIPPON
SODA
COMPANY,
LTD.
14
p.

92166059
Jordan,
R.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
40375701
and
Related
MRIDs
40611405,
00130578.
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Celery;
Freezer
Storage
Stability
of
Sethoxydim
and
Its
Metabolites
in
Legume
Vegetables;
Freezer
Storage
Stability
of
BAS
9052
H
and
MSO,
Its
Metabolite,
in
Soybean
Forage:
REG
DOC
#
BASF
90/
6068,
A8732,
A8736
and
SR­
79.
Prepared
by
NIPPON
SODA
COMPANY,
LTD.
15
p.

92166060
Jordan,
R.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
40375704
and
Related
MRIDs
40611405,
00130578.
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Spinach;
Freezer
Storage
Stability
of
Sethoxydim
and
Its
Metabolites
in
Legume
Vegetables;
Freezer
Storage
Stability
of
BAS
9052
H
and
MSO,
Its
Metabolite,
in
Soybean
Forage:
REG
DOC
#
BASF
90/
6069;
BASF
Report
Nos.
A8731,
A8736,
SR­
79.
Prepared
by
NIPPON
SODA
COMPANY,
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
89
of
101
LTD.
15
p.

92166061
Jordan,
R.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
40375702
and
Related
MRIDs
40611405,
00130578.
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Head
Lettuce;
Freezer
Storage
Stability
of
Sethoxydim
and
Its
Metabolite
in
Legume
Vegetables;
Freezer
Storage
Stability
of
BAS
9052
H
and
MSO,
Its
Metabolite,
in
Soybean
Forage:
REG
DOC
#
BASF
90/
6067;
BASF
Report
Nos.
A8729,
A8736
and
SR­
79.
Prepared
by
NIPPON
SODA
COMPANY,
LTD.
13
p.

92166063
Burkey,
J.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
00131857
and
Related
MRIDs
40391201,
00130578,
40391201.
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Peanuts
and
Peanut
Hulls;
Freezer
Storage
Stability
of
BAS
9052
H
and
Its
Metabolites
in
Soybean
Seed;
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Peanuts,
Peanuts
Hulls
and
Peanut
Hay:
REG
DOC
90
6057;
BASF
Report
Nos.
PR­
227,
A8721,
SR­
85.
Prepared
by
BASF
WYANDOTTE
CORP.
15
p.

92166066
Eubanks,
M.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
00157187.
Magnitude
of
the
Residue
of
Sethoxydim
and
Its
Metabolites
in
Raspberries;
Freezer
Storage
Stability
of
Weathered
Sethoxydim
Derived
Residues
in
Strawberries:
REG
DOC
#
BASF
90/
6064;
Report
No.
CR­
27
BASF
Report
SR­
108;
Report
No.
CR­
26;
REG.
DOC.
BASF
90/
6063.
Prepared
by
CRAVEN
LABORATORIES,
INC.
26
p.

92166067
Burkey,
J.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
00155129
and
Related
MRIDs
40145601,
40639102,
40639101,
40195103,
40639101.
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Sugarbeet
Tops
and
Sugarbeet
Roots;
Freezer
Storage
Stability
of
Sethoxydim
Metabolites
MSO
and
5­
OH­
MSO2
in
Potatoes;
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Sugarbeet
Roots
and
Tops:
REG
DOC
90/
6091;
BASF
Report
Nos
PR­
255,
A8702,
A8719,
A8722
and
A8705.
Prepared
by
NIPPON
SODA
CO.
LTD.
23
p.

92166068
Looper,
G.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
00131857
and
Related
MRIDs
00130578.
Determination
of
Sethoxydim
and
Its
Metabolite
Residues
in
Sunflower
Seed
Samples:
Freezer
Storage
Stability
of
BAS
9052
H
and
Its
Metabolites
in
Soybean
Seed:
REG
DOC
90/
6059;
BASF
Report
No.
PR­
232
and
SR­
85.
Prepared
by
BASF
WYANDOTTE
CORP.
13
p.

92166072
Eubanks,
M.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
40725801
and
Related
MRIDs
00130578,
00157187.
Magnitude
of
the
Residue
of
Sethoxydim
and
its
Metabolites
in
Grapes;
Freezer
Storage
Stability
of
BAS
9052
and
MSO,
Its
Metabolite
in
Soybean
Forage:
BASF
Report
No.
SR­
79;
Freezer
Storage
Stability
of
Weathered
Sethoxydim
Derived
Residues
in
Strawberries;
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
90
of
101
Magnitude
of
the
Residue
of
Sethoxydim
and
its
Metabolites
in
Grapes.
Prepared
by
CRAVEN
LABORATORIES,
INC.
15
p.

92166078
Eswein,
R.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
00127281
and
Related
MRIDs
00110510.
Determination
of
Sethoxydim
and
Its
Metabolite
Residues
in
Cottonseed
Process
Fractions
(
Meal,
Hulls,
Crude
Oil,
Refined
Oil
and
Soapstock);
Freezer
Storage
Stability
of
BAS
9052
H
and
its
Metabolites
in
Soybean
Seed:
REG
DOC
#
BASF
90/
6056;
BASF
Report
Nos
PR­
211,
PR­
211a
and
SR­
85.
Prepared
by
BASF
WYANDOTTE
CORP.
11
p.

92166080
Burkey,
J.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
00162633
and
Related
MRIDs
00148007.
Determination
of
Sethoxydim
and
Its
Metabolite
Residues
in
Tomato
Process
Fractions
(
Wet
Pomace,
Dry
Pomace,
Puree,
Catsup,
and
Juice);
The
Freezer
Storage
Stability
of
Sethoxydim
Metabolites
MSO
and
5­
OH­
MSO2
in
Tomato
Samples:
REG
DOC
#
BASF
90/
6062;
BASF
Report
No.
SR­
118.
Prepared
by
BASF
AKTIENGESELLSCHAFT.
11
p.

92166081
Burkey,
J.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
00131857
and
Related
MRIDs
00130578.
Determination
of
Sethoxydim
and
its
Metabolite
Residues
in
Peanut
Process
Fractions
(
Screwpress
Cake,
Solvent
Extracted
Screwpress
Cake,
Crude
Oil,
Soapstock,
and
Refined
Oil);
Freezer
Storage
Stability
of
BAS
9052
H
and
its
Metabolites
in
Soybean
Seed:
REG
DOC
#
BASF
90/
6058;
BASF
Report
PR­
228
and
SR­
85.
Prepared
by
BASF
WYANDOTTE
CORP.
11
p.

92166082
Nichols,
K.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
40195102
and
Related
MRIDs
40195103.
Determination
of
Sethoxydim
and
its
Metabolite
Residues
in
Potato
Process
Fractions
(
Granules,
Flakes,
Chips,
and
Peels);
Freezer
Storage
Stability
of
Sethoxydim
Metabolites
MSO
and
5­
OH­
MSO2
in
Potatoes:
REG
DOC
#
BASF
90/
6072;
BASF
Report
No.
A8904
and
A8705.
Prepared
by
BASF
CORPORATION.
14
p.

92166083
Burkey,
J.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
00100535
and
Related
MRIDs
00130578.
Sethoxydim
and
Its
Metabolite
Residues
in
Soybean
Seed
Process
Fractions
(
Soybean
Seed
Meal,
Hulls,
Soapstock,
Crude
oil
and
Refined
Oil);
Freezer
Storage
Stability
of
BAS
9052
H
and
Its
Metabolites
in
Soybean
Seed
BASF
Report
No.
SR­
85:
REG
DOC
#
BASF
90/
6055;
BASF
Report
Nos.
PR­
204,
PR­
204A
and
SR­
85.
Prepared
by
BASF
WYANDOTTE
CORP.
11
p.

92166085
Burkey,
J.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
00131857
and
Related
MRIDs
00130578.
Determination
of
Sethoxydim
and
its
Metabolite
Residues
in
Sunflower
Seed
Process
Fractions
(
Sunflower
Seed
Meal,
Hulls,
Crude
Oil
and
Refined
Oil);
Freezer
Storage
Stability
of
BAS
9052
H
and
its
Metabolites
in
Soybean
Seed:
REG
DOC
#
BASF
90/
6060;
BASF
Report
No.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
91
of
101
PR­
233
and
SR­
85.
Prepared
by
BASF
WYANDOTTE
CORP.
11
p.

92166086
Zehr,
R.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
40492605.
Determination
of
Sethoxydom
and
Its
Metabolite
Residues
in
Orange
Process
Fractions
(
Dried
Pulp,
Wet
Pulp,
Peel,
Oil,
Molasses
and
Juice);
Magnitude
of
the
Residues
of
Sethoxydim
and
Metabolites
in
Oranges:
REG
DOC
#
BASF
90/
6076;
BASF
Report
Nos.
A8745
and
A8744.
Prepared
by
Nippon
Soda
Co.
Ltd.
11
p.

92166087
Zehr,
R.
(
1990)
BASF
Corporation
Phase
3
Summary
of
MRID
40576103
and
Related
MRIDs
40576101.
Determination
of
Sethoxydim
and
its
Metabolite
Residues
in
Apples
Process
Fractions
Wet
Pomace,
Dry
Pomace,
Juice;
Magnitude
of
the
Residue
of
Sethoxydim
and
Metabolites
in
Apples.
REG
DOC
#
BASF
90/
6078;
BASF
Report
No.
A8752
and
A8750.
Prepared
by
NIPPON
SODA
CO
LTD.
10
p.

92166094
Wood,
N.;
Beutel,
P.
(
1990)
BASF
Corporation
Phase
3
Reformat
of
MRID
00042798
and
Related
MRIDs
00079004,
00153602.
Sethoxydim:
Nature
of
the
Residue:
Plant
Study:
REG
DOC
90/
6104;
BASF
Report
Nos.
PM­
28,
1744,
RD­
8484N.
Prepared
by
BASF
WYANDOTTE
CORP.
104
p.

92166095
Paulick,
R.;
Gorski,
J.;
Wood,
N.
(
1990)
BASF
Corporation
Phase
3
Reformat
of
MRID
00110510.
Sethoxydim:
Nature
of
Residues
in
Cotton:
BASF
Registration
Document
#
82/
5033,
BWC
Report
No.
PM­
37;
REG
DOC
#
BASF
90/
6099.
Prepared
by
BASF
WYANDOTTE
CORP.
36
p.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
92
of
101
Agency
Memoranda
Citations.

Date
DP
Barcode
CB
No.
ID
Number
From
To
MRID
Nos.
Subject
*
12/
4/
80
PP#
0G2396
E.
Zager
*
7/
23/
82
PP#
2F2670
M.
J.
Nelson
4/
1/
83
PP#
2F2670
K.
Kissler
J.
Onley
Method
Validation
for
Method
30.

*
1/
12/
84
PP#
3F2904
J.
Onley
*
6/
26/
85
PP#
3F2904
K.
Arne
7/
17/
85
RCB
#
943
and
944;
PP#
5F3234/
FA
P#
5H5464
M.
Firestone
R.
Taylor
Accession
No.
073424
Sethoxydim
(
Poast
®
)
on
Sunflowers
and
Peanuts.

Evaluation
of
Analytical
Methods
and
Residue
Data
*
6/
29/
84
PP#
3F2950
K.
Arne
*
10/
9/
85
PP#
5F3284/
5H
5475
C.
Deyrup
*
6/
23/
86
RCB
#
306
S.
Malik
11/
2/
88
PP#
3F2904.
S.
Malak
R
Taylor/
V.

Walters
PP#
3F2904.
Sethoxydim
(
Poast
®
)
on
Alfalfa
and
Soybeans.
Method
Validation
Report.
Mo
MRID
or
DEB
Numbers.

*
11/
4/
88
PP#
8F3640
H.
Fonouni
11/
7/
88
S.
Malak
FDA
PAM
II
Submission
2/
27/
90
DEB
Nos.
5869
and
5870;
HED
Project
No.
9­

2229A
RD
Record
Nos.
252854
and
253195
PP#
9F3806
L.
F.
Rodriguez
R.
Taylor
41248401,
41248402,

41248403,
and
41248404.
PP#
9F3806.
Sethoxydim
(
Poast
®
t)
in
or
on
Corn.

Evaluation
of
Analytical
Method
and
Residue
Data.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Agency
Memoranda
Citations.

Date
DP
Barcode
CB
No.
ID
Number
From
To
MRID
Nos.
Subject
93
of
101
5/
4/
90
M.
Bradley
A.
Marcotte,

FDA
Addenda
to
Method
30;

Method
30G
submitted
as
Method
A
in
PAM
Volume
II;

Method
30H
submitted
as
Method
B
in
PAM
Volume
II.

8/
8/
90
DES
#:
5854,

5855,
5856
PP9F3804/
PP9
H5589
S.
Inasi
R.
Taylor/

V.
K.
Walters
41236401,
41236402,

41236403,
41236404,

41236405,
41236406.
PP#
9F3804/
PP#
9H5589,
(
EPA
Reg.
No.
7969
 
58):

Sethoxydim
(
POAST
®
Herbicide)
In
or
On
Stone
fruits.
Evaluation
Analytical
Method
and
Residue
Data.

2/
7/
91
PP0F3855
M.
J.
Nelson
R.
Taylor/

V.
Walters
41428501,
41428502,

41428503
Petition
Review
for
Establishment
of
Tolerance
(
s).

Evaluation
of
Analytical
Method(
s)
and
Residue
Data.

Tree
Nuts
and
Almond
Hulls.

2/
14/
91
PP#
0E3909
M.
J.
Nelson
A.
Beard
and
H.

Jamerson
41627000
and
41627001.
Data
Review
Quick
Form
­

Petition
Review
for
Establishment
of
Tolerance(
s).

Evaluation
of
Analytical
Method(
s)
and
Residue
Data.

Cranberries.

2/
25/
91
L.
Cheng
Phase
IV
Review
­
Sethoxydim
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Agency
Memoranda
Citations.

Date
DP
Barcode
CB
No.
ID
Number
From
To
MRID
Nos.
Subject
94
of
101
9/
23/
91
D165411
CB
#
8461.
L.
Cheng
R.
Taylor
Sethoxydim
(
Poast
®
)
.
Impact
of
Craven
Analytical
Data
on
Registrations:
alfalfa,
forage
and
hay;
beans,
dry,
forage
and
hay;
beans,
succulent;
Brassica
leafy
vegetables
(
cabbage,

broccoli,
cauliflower
and
mustard);
cottonseed;
flaxseed
and
straw;
fruiting
vegetables
(
tomato
and
pepper);
grapes;

lentils;
peanuts
and
hull;
peas,

dry,
forage
and
hay;
peas,

succulent;
potatoes;
soybeans;

sugar
beet
tops;
and
sweet
potatoes.

10/
9/
91
D167911,

D167912
HED#:
1­
2333
CBTS#:
8544,

8545
PP#
0F3855
and
0E3900.
M.
J.
Nelson
R.
Taylor/

V.
Walters
41980701
PP#
0F3855
and
0E3900.

Sethoxydim
(
Poast
®
)
.

Submission
of
8/
9/
91:

Multiresidue
Protocol
Data.

1/
24/
92
D165957,

D169251
&

D170139
DEB
Nos.

8283,
8706,

and
8813
C.
Swartz
L.
Deluise
Sethoxydim.
Reregistration
Case
No.
2600.
Chemical
No.

121001.
BASF
Phase
4
Response
regarding
Guideline
Requirements
171­
4(
b),
Nature
of
the
Residue­­
Livestock,
and
171­
4(
k),
Magnitude
of
the
Residue­­
RAC
(
soybeans).

2/
11/
92
D172349
CBTS
No.

9078
HED
No.

2­
0777
PP#
2E4052
W.
Wassell
H.
Jamerson
42101701,
42101702
PP#
2E4052
Sethoxydim
(
Poast
®
Herbicide,
EPA
Reg.

No.
7969­
58)
in
or
on
mint.

Evaluation
of
analytical
method
and
magnitude
of
residue
data.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Agency
Memoranda
Citations.

Date
DP
Barcode
CB
No.
ID
Number
From
To
MRID
Nos.
Subject
95
of
101
2/
19/
92
D167888,
D167906,

D167908
CB
Nos.
8540,

8541,
8542
PP#
8F03646/

FAP#
8H05558.
W.
Wassell
R.
Taylor
41966101
PP#
8F03646/
FAP#
8H05558.

Sethoxydim
(
Poast
®
Herbicide,
7969­
58)
in
or
on
Sugar
Beet
Roots
and
Process
Fractions.
EPA
Reg.
No,

Amendment
of
8/
2/
91.

6/
24/
92
D172550
CBTS
No.

9130,
MED
No.
2­
0824
M.
H.
Peters
40375703,
40375704
PP#
2E04065
Sethoxydim
(
Poast
®
Herbicide,
EPA
Reg.

No.
7969
 
58)
in
or
on
endive;

the
evaluation
of
analytical
method
and
the
magnitude
of
residue
data.

8/
7/
92
D174374
HED
#
2­
1389
M.
I.
Rodriguez
H.
Jamerson/

L.
Fried
42195001
ID
#
PP2E4092:
Sethoxydim
(
Poast
®
)
in/
on
carrots.

Evaluation
of
analytical
and
residue
data.

8/
20/
92
D178826
CBRS
No.

9938
C.
Swartz
J.
Ellenberger
Sethoxydim.
List
B
Reregistration
Case
No.

2600/
Chemical
ID
No.

121001.
Request
for
waiver
of
the
Guideline
Requirement
171­
4(
j),
Poultry
Feeding
Study.

9/
21/
92
D171714,
D171716,
D171724,
CBTS
Nos.

9055,
9056,

9057.

HED
Nos.
2­

0664.
B.
Schneider
V.
Walters/
R.

Taylor
42074201,
42074202
PP#
2F04041/
FAP#
2H5621.

Sethoxydim
(
Poast
®
Herbicide,
EPA
Reg.
No.

7969­
58)
in
or
on
Canola/
Rape.
Evaluation
of
Magnitude
of
the
Residue
Data
and
Processing
Study.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Agency
Memoranda
Citations.

Date
DP
Barcode
CB
No.
ID
Number
From
To
MRID
Nos.
Subject
96
of
101
11/
23/
92
D182749
10607
B.
Schneider
V.
Walters/

R.
Taylor
Amended
Registration
for
Sethoxydim
(
Poast
®
Herbicide,
EPA
Reg.
No.

7969­
58)
in
or
on
Soybeans
to
Reduce
the
PHI.

12/
4/
92
D183351
10706
D.
Davis
H.
L.
Jamerson
42487401,
42487402.
PP#
3E4162
Sethoxydim
(
Poast
®
Herbicide,
EPA
Reg.

No.
7969­
58)
in
or
on
asparagus.
Evaluation
of
analytical
method
and
magnitude
of
residue
data.

12/
7/
92
D183351
CBTS
No:

10706
D.
Davis
H.
L.
Jamerson
42487401,
42487402.
PP#
3E4162
Sethoxydim
(
Poast
®
Herbicide,
EPA
Reg.

No.
7969­
58)
in
or
on
asparagus.
Evaluation
of
analytical
method
and
magnitude
of
residue
data.

8/
3/
93
D189273
CBTS#
11575.
G.
Kramer
K.
Davis
42825
and
41510612
ID#
121001­
007969.
Review
of
rotational
crop
studies
of
sethoxydim
(
Poast
®
Herbicide,

EPA
Reg.
No.
7969­
58).

8/
4/
93
D193362
CBTS
No:

12278.
D.
Davis
H.
L.
Jamerson
42834201,
42834202
PP#
3E4162.
Sethoxydim
(
POAST
®
Herbicide)
in/
on
Asparagus.
Evaluation
of
Amendment
Dated
6/
25/
93
(
Amended
Section
B
and
Additional
Raw
Data).

8/
6/
93
D182748,
D182746,
D182747,
D193019,
D193020,
D193021.
CB
Nos.

10608,
10609,

10610,
12209,

12210,
12211
W.
Wassell
R.
Taylor
/

V.
Walters
42839001
PP#
8F03646/
FAP#
8H05558.

Sethoxydim
(
Poast
®
Herbicide,
EPA
Reg.
No.

7969­
58)
in
or
on
Sugar
Beet
Roots
and
Process
Fractions.

Amendment
of
5/
20/
92.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Agency
Memoranda
Citations.

Date
DP
Barcode
CB
No.
ID
Number
From
To
MRID
Nos.
Subject
97
of
101
8/
25/
93
D185410
CBTS
#:

20027.
M.
I.
Rodriguez
H.
L.
Jamerson
PP2E4092:
Sethoxydim
(
Poast
®
)
­
Response
to
CBTS
Review
#
9394
(
Memo
of
M.
I.

Rodríguez,
August
7,
1992)
­

in/
on
Carrots.
Amendment
of
November
18,
1992.

9/
16/
93
D179955
&

D179957
CBTS
#'
s:

10136
&

10137.
M.
I.
Rodriguez
R.
Taylor,
V.

Walters
and
A.
Kocialski
423536
ID
#
PP2F4121
&
EPA
Reg.

No.
7969­
58.
Sethoxydim
(
Poast
®
)
in
or
on
Clover.

Evaluation
of
Analytical
Method
and
Residue
Data.

4/
19/
94
D192620
CBRS
12132
F.
Suhre
428168­
01
Sethoxydim
(
ID
121001).

Residue
Chemistry
Data
Requirement
171­
4(
l)
for
alfalfa
4/
21/
94
D197875
CBTS
No:

13091
D.
Davis
H.
L.
Jamerson
43051701
PP#
3E4162.
Sethoxydim
(
POAST
®
Herbicide)
in/
on
Asparagus.
Evaluation
of
Amendment
Dated
12/
3/
93.

4/
26/
94
D198048
CBRS
No.

13031
L.
Cheng
B.
Adler
43062201,
43062202,

43062203,
43062204
&
43062205.
Sethoxydim.
Case
No.
2600.

Magnitude
of
Residues
in
Tomatoes,
Squash,

Cantaloupe,
Mustard
Greens,

and
Cotton.

6/
24/
94
D198947
CBRS
13159
K.
W.
Dockter
B.
Adler
41607201
through
41607206
Sethoxydim.
BASF
Response
[
Series
61,
62­
1,
62­
2
&
Series
63
data
for
the
technical
&
for
the
50%
FI;
7969­
56]
to
L.

Cheng's
5/
13/
93
Review
[
Phase
4]
Rereg.
Case
2600.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Agency
Memoranda
Citations.

Date
DP
Barcode
CB
No.
ID
Number
From
To
MRID
Nos.
Subject
98
of
101
8/
15/
94
D203246
CBRS
No.

13707
L.
Cheng
B.
Adler
43223401
Sethoxydim.
Case
No.
2600.

Stability
in
Animal
Matrices
under
Frozen
Conditions.

8/
22/
94
D200363
CBRS
No.

13402
L.
Cheng
B.
Adler
41970901
Sethoxydim.
Case
No.
2600.

Magnitude
of
Residue
on
Alfalfa.

9/
16/
94
D200367
CBRS
No.

13401
L.
Cheng
B.
Adler
43144501
Sethoxydim.
Case
No.
2600.

Metabolism
in
Sugar
Beets.

12/
1/
94
D205049
CBRS
No.

14014
L.
Cheng
B.
Adler
43282401
Sethoxydim.
Case
No.
2600.

Magnitude
of
Residue
in
Cucumbers.

12/
20/
94
D207478
and
D207480
CBRS
No.

14393
&
14394
PP#
4F4413
L.
Cheng
R.
Taylor
PP#
4F4413/
Reregistration.

Sethoxydim
on
Cucurbit
Vegetables.
Revised
Crop
Group
Tolerance.

1/
3/
95
D210046
CBRS
No.

14814
L.
Cheng
B.
Adler
43467001
Sethoxydim.
Case
No.
2600.

Additional
Data
on
Sugar
Beet
Metabolism.

1/
19/
95
D209952
CBRS
No.

14789
L.
Cheng
B.
Adler
Sethoxydim.
Case
No.
2600.

Tolerances
on
Alfalfa
Forage
and
Hay.

7/
24/
95
D210060,
D210062,
D208310,
&

D208312
14852,
14853,

14504,
&

14505
M.
I.
Rodriguez
R.
Taylor,
V.

Walters,

J.
Smith
434557­
00,
434557­

01,
431787­
01,

431787­
02,
&

431787­
03.
PP4F04344,
ID
#
007969­

00058
BASF
Poast
®
Herbicide:
Sethoxydim
in/
on
Sethoxydim­
resistant
Corn.

Increase
in
Tolerance
Values.

Amendments
Dated
March
15,

1994,
August
18,
1994,

September
13,
1994,
and
November
17,
1994.
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Agency
Memoranda
Citations.

Date
DP
Barcode
CB
No.
ID
Number
From
To
MRID
Nos.
Subject
99
of
101
4/
9/
96
D219970
CBRS
16310
L.
Cheng
B.
Adler
43801401
through
43801405
Sethoxydim.
Case
2600.

Craven
Replacement
Data:

Freezer
Storage
in
Fruit
and
Vegetable
Crops;
Residue
in
Tomatoes,
Broccoli,
Mustard
Greens,
and
Cabbage
3/
4/
97
D212794
B.
Schneider
4/
4/
97
­­
CBRS
17851
L.
Cheng
P.
Deschamp
Sethoxydim.
Case
2600.

Phase
V
Review
of
Soybeans,

Tomatoes,
Goats,
and
Poultry
Metabolism
Studies.

7/
28/
97
D237724
CBRS
16311,

16312,
16317
&
16318
L.
Cheng
K.
Whitby
43801406
through
43801416
Sethoxydim.
Case
2600.
PC
Code
121001.
Craven
Replacement
Residue
Data
for
Pepper,
Potato,
Peanut,
Flax,

Grape,
Succulent
and
Dry
Bean,
Succulent
and
Dry
Pea,

Grape
Processing,
and
Additional
Residue
Data
for
Soybean.

*
4/
8/
98
D238439
­­­
PP#
6E4753,
W.
Cutchin
­­­
­­­
­­­

*
5/
24/
98
­­­
­­­
­­­
R.
Loranger
­­­
­­­
Metabolism
Assessment
Review
Committee
meeting
on
5/
14/
98
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Agency
Memoranda
Citations.

Date
DP
Barcode
CB
No.
ID
Number
From
To
MRID
Nos.
Subject
100
of
101
6/
12/
98
D225427
­­­
­­­
M.
Cutchin
R.
Forrest
439727­
00,
­
01
43973
1­
00,
­
01
SETHOXYDIM.
Human
Risk
Assessment
for
the
change
from
time­
limited
to
permanent
tolerances
on
carrots,
asp
cranberries,

endive,
and
mint.
Request
for
tolerances
on
leafy
vegetables
(
except
Brassica)
crop
group
and
cilantro,
and
the
root
and
tuber
(
except
radish)
vegetable
crop
group.
Request
for
increase
in
tolerance
on
grapes,
soybeans,
beans,

caneberries,
globe
artichokes
and
raisins.

8/
9/
01
D256970
PP#
9E06012
N.
Dodd
S.
Brothers/

R.
Forrest
PP#
9E06012.
Sethoxydim
on
Pistachio.
Review
of
Analytical
Methods
and
Residue
Data.

1/
24/
02
D257559
PP#
9E06021
N.
Dodd
S.
Brothers/
R.

Forrest
44864501
PP#
9E06021.
Sethoxydim
on
Safflower.
Review
of
Analytical
Methods
and
Residue
Data.

7/
5/
02
D266208/
D2
66210
PP#
2F04075
N.
Dodd
45100501
DER
­
Crop
Field
and
Residue
Decline
Trials
­
SR
®
(
Sethoxydim­
Resistant)
Sweet
Corn;
OPPTS
860.1500
Sethoxydim
Summary
of
Analytical
Chemistry
and
Residue
Data
Barcode:
D318169
Agency
Memoranda
Citations.

Date
DP
Barcode
CB
No.
ID
Number
From
To
MRID
Nos.
Subject
101
of
101
7/
19/
02
D278583
PP#
0E06150
N.
Dodd
S.
Brothers/

R.
Forrest
PP#
0E06150.
Sethoxydim
on
Fresh
Herbs,
Except
Lemongrass;
Lingonberry,

Juneberry,
Salal,
and
Tropical
Fruit.
Review
of
Analytical
Methods
and
Residue
Data.

12/
10/
98
D251542
PP#
9E5049.
G.
J.
Herndon
H.
Jamerson/

R.
Forrest
PP#
9E5049.
SETHOXYDIM.

Revisit
of
the
IR­
4
Request
for
a
Tolerance
on
the
Root
and
Tuber
(
Except
Radish)

Vegetable
Crop
Group
(
Crop
Group
1
as
Denoted
in
40
CFR
180.41)
at
4.0
ppm.
Request
for
4.0
ppm
Tolerance
on
Horseradish
Based
on
Existing
Field
Trial
Residue
Data
from
Other
Crops
in
Crop
Group
1.

8/
11/
03
D292905
­­­
­­­
D.
Soderberg
M.
Bonner
­­­
Sethoxydim.
Acute
Dietary
Exposure
Assessment
for
Section
3
Registration
Actions
Date
Unknown
D192620
CBRS
No.

12132
F.
Suhre
K.
Davis
42816801
Sethoxydim
(
ID
121001).

Residue
Chemistry
Data
Requirement
171­
4(
l)
for
alfalfa.

*
The
citations
were
mentioned
in
other
EPA
memos
reviewed
by
Versar.