Document ID: EPA-HQ-ORD-2006-0187-0057
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2006-03-31T05:00Z

3/
29/
06
EPA
HUMAN
STUDIES
REVIEW
BOARD
MEMBER
BIOSKETCHES
Dr.
David
Bellinger
Dr.
David
C.
Bellinger
is
Professor
of
Neurology,
Harvard
Medical
School,
Professor
in
the
Department
of
Environmental
Health,
Harvard
School
of
Public
Health
(
HSPH),
and
Senior
Research
Associate
in
Neurology
and
Psychiatry,
Children's
Hospital
Boston.
He
received
a
Ph.
D.
in
Psychology
from
Cornell
University
in
1977
and
completed
post­
doctoral
fellowship
training
at
the
University
of
Rochester
School
of
Medicine
and
Boston
University.
In
1987,
he
received
a
M.
Sc.
in
Epidemiology
from
the
HSPH.
He
received
a
Research
Career
Development
Award
from
the
NIEHS
(
1985­
1990).
He
currently
directs
an
NIH­
funded
T32
Interdisciplinary
Training
Program
in
Neurodevelopmental
Toxicology
at
the
HSPH.
He
has
served
on
several
committees
of
the
National
Academies/
National
Research
Council/
Institute
of
Medicine,
including
Measuring
Lead
Exposure
in
Infants,
Children,
and
Other
Sensitive
Populations;
Toxicological
Effects
of
Methylmercury;
Submarine
Escape
Action
Levels;
and
Nutrient
Relationships
in
Seafood:
Balancing
the
Benefits
and
Risks.
He
has
participated
in
World
Health
Organization
(
WHO)
consultations
involving
lead,
mercury,
and
principles
of
risk
assessment.
On
several
occasions,
he
has
been
a
Technical
Advisor
to
the
FAO/
WHO
Joint
Expert
Committee
on
Food
Additives
and
Contaminants
(
JECFA),
as
well
as
serving
as
a
member
of
JECFA.
From
2001­
2004,
he
was
a
member
of
the
Federal
Advisory
Committee
of
the
National
Children's
Study.
He
participated
in
the
EPA
Science
Advisory
Board
review
of
the
Agency's
Mercury
Report
to
Congress.
He
has
served
as
Epidemiology
Section
Editor
of
Neurotoxicology
and
Teratology
and
is
the
editor
of
a
forthcoming
volume
on
Human
Developmental
Neurotoxicology.
His
major
research
interests
are
the
developmental
impact
of
early
metabolic
and
chemical
insults
to
the
nervous
system
and
neuropsychological
toxicology.
Much
of
his
research
has
focused
on
the
neurotoxicity
of
metals
in
children,
particularly
lead,
mercury,
arsenic,
and
manganese.
His
research
has
been
funded
primarily
by
the
NIH
(
NICHD,
NIEHS,
NINDS,
NIDCR,
NHLBI),
and
by
EPA,
the
Agency
for
Toxic
Substances
and
Disease
Registry,
and
Harvard
University.

Dr.
Stephen
Brimijoin
Dr.
Stephen
Brimijoin
is
Clement
Professor
and
past
Chair
(
1993­
2003)
of
Pharmacology
at
Mayo
Medical
School
and
Distinguished
Investigator
at
Mayo
Clinic,
which
he
joined
in
1971
after
two
years
at
the
National
Institutes
of
Health.
For
over
thirty
years
he
has
investigated
the
neurobiology,
pharmacology,
and
toxicology
of
cholinesterase
enzymes,
including
studies
on
the
pathophysiology
of
their
axonal
transport
in
human
peripheral
nerve.
He
contributed
substantially
to
knowledge
of
the
cellular
distribution
and
fate
of
the
molecular
forms
of
these
enzymes
in
brain.
He
discovered
that
anti­
esterase
antibodies
destroy
central
sympathetic
neurons
in
a
selective
manner
that
provides
insights
into
the
pathophysiology
of
the
autonomic
nervous
system.
He
used
genetically
engineered
neuronal
cell
lines
to
show
that
this
acetylcholinesterase
may
promote
nerve
growth
and
maturation,
in
addition
to
regulating
cholinergic
transmission.
More
recently,
his
research
team
modified
human
plasma
cholinesterase
to
produce
a
cocaine­
metabolizing
enzyme
that
blocks
physiological
responses
to
2
this
drug
and
may
pave
the
way
for
a
gene
therapy
of
addiction.
In
cholinergic
toxicology,
Dr.
Brimijoin
helped
generate
more
potent
oxime
reactivators
to
rescue
individuals
from
pesticide
overdose,
and
he
devised
a
new
method
to
detect
cholinesterase
inhibition
that
yields
more
precise
benchmark
doses
for
carbamate
pesticides.
He
is
now
investigating
the
developmental
neurotoxicity
of
organophosphates,
on
which
he
provided
invited
testimony
to
the
NAS
Committee
on
the
Use
of
Third
Party
Toxicity
Research
with
Human
Research
Participants.
Dr.
Brimijoin
has
served
on
the
editorial
boards
of
several
journals
(
currently,
Molecular
and
Cellular
Neurobiology)
and
on
the
Mayo
Human
Studies
Committee
(
IRB).
For
over
ten
years
he
has
been
an
ad
hoc
member
of
multiple
sessions
of
the
EPA
FIFRA
Scientific
Advisory
Panel
(
FIFRA
SAP).
In
recognition
for
research
accomplishments,
he
received
a
Javits
Neuroscience
Investigator
Award
(
1987­
94)
a
Humboldt
Foundation
Senior
Distinguished
U.
S.
Scientist
Award
(
1987­
88)
and
an
annual
Distinguished
Investigator
Award
from
Mayo
Clinic
(
1992­
present).
He
completed
his
undergraduate
and
graduate
training
at
Harvard
(
B.
A.,
1964;
Ph.
D.,
1969).

Dr.
Alicia
Carriquiry
Dr.
Alicia
Carriquiry
is
professor
of
statistics
and
director
of
graduate
education
at
Iowa
State
University.
Between
January
of
2000
and
July
of
2004
she
was
Associate
Provost
at
Iowa
State
University.
Her
research
interests
are
in
Bayesian
statistics
and
general
methods.
Her
recent
work
focuses
on
nutrition
and
dietary
assessment,
as
well
as
on
problems
in
genomics,
forensic
sciences
and
traffic
safety.
She
currently
teaches
the
graduate­
level
course
on
Bayesian
data
analysis
at
Iowa
State
University
and
has
five
doctoral
students
working
under
her
supervision
at
this
time.
She
is
an
elected
member
of
the
International
Statistical
Institute
and
a
Fellow
of
the
American
Statistical
Association.
Dr.
Carriquiry
served
on
the
Executive
Committee
of
the
Institute
of
Mathematical
Statistics
between
1999
and
2005
and
has
been
a
member
of
the
Board
of
Trustees
of
the
National
Institute
of
Statistical
Sciences
since
1997.
She
is
also
a
past
president
of
the
International
Society
for
Bayesian
Analysis
(
ISBA)
and
a
past
member
of
the
Board
of
the
Plant
Sciences
Institute
at
Iowa
State
University.
Dr.
Carriquiry
is
Editor
of
Statistical
Sciences
and
of
Bayesian
Analysis,
Associate
Editor
of
Statistical
Surveys
and
serves
on
the
editorial
boards
of
several
Latin
American
journals
of
statistics
and
mathematics.
She
has
served
on
three
National
Academy
of
Sciences
committees:
the
Subcommittee
on
Interpretation
and
Uses
of
Dietary
Reference
Intakes;
the
Committee
on
Evaluation
of
USDA's
Methodology
for
Estimating
Eligibility
and
Participation
for
the
WIC
Program
and
the
Committee
on
Third
Party
Toxicity
Research
with
Human
Research
Participants.
Currently,
she
is
a
member
of
the
standing
Committee
on
Applied
and
Theoretical
Statistics
of
the
National
Research
Council,
the
Committee
on
Assessing
the
Feasibility,
Accuracy
and
Technical
Capability
of
a
Ballistics
National
Database
of
the
National
Research
Council
and
of
the
Committee
on
Gender
Differences
in
the
Careers
in
Science,
Mathematics
and
Engineering
Faculty
of
the
National
Academy
of
Sciences.
She
is
a
member
of
the
Federal
Steering
Committee
Future
Directions
for
the
CSFII/
NHANES
Diet/
Nutrition
Survey:
What
we
Eat
in
America
and
also
a
member
of
the
NIH
Kidney,
Nutrition,
Obesity
and
Diabetes
Study
Section.
Carriquiry
received
a
MSc
in
animal
science
from
the
University
of
Illinois,
and
an
MSc
in
statistics
and
a
PhD
in
statistics
and
animal
genetics
from
Iowa
State
University.

Dr.
Janice
Chambers
3
Dr.
Chambers
is
the
William
L.
Giles
Distinguished
Professor
and
Director,
Center
for
Environmental
Health
Sciences
Professor,
Department
of
Basic
Sciences
at
Mississippi
State
University.
Dr.
Chambers
directs
several
research
projects
that
deal
with
the
effects
of
pesticides
in
mammalian
systems
to
determine
the
potential
human
health
effects
of
pesticide
exposures.
Specifically,
there
are
projects
related
to
the
neurochemical
and
behavioral
effects
of
pesticides
in
developing
organisms
as
well
as
the
metabolism
of
pesticides
in
developing
organisms
to
yield
predictions
about
potential
effects
of
pesticides
in
infants
and
children.
Other
projects
are
involved
in
developing
mathematical
predictions
of
the
effects
of
mixtures
of
pesticides
on
the
nervous
system
so
that
predictive
models
can
be
generated
to
potentially
describe
the
effects
of
future
uncharacterized
mixtures.
Dr.
Chambers
has
been
the
Principal
Investigator
for
numerous
federally
funded
competitive
grants
in
the
field
of
toxicology.
Because
of
her
expertise,
she
has
been
asked
to
serve
on
a
number
of
advisory
boards
and
prestigious
committees.
Dr.
Chambers
is
board
certified
as
a
toxicologist
by
the
American
Board
of
Toxicology
and
the
Academy
of
Toxicological
Sciences.
As
Director
of
the
Center
for
Environmental
Health
Sciences,
she
has
developed
an
interdisciplinary
research
center
specializing
in
pesticide
toxicology
and
funded
primarily
by
NIH.
The
center
comprises
the
areas
of
neurotoxicology,
biochemical
toxicology,
analytical
chemistry,
biostatistics,
epidemiology,
computational
chemistry,
computational
simulation,
biochemistry,
and
endocrinology.
Dr.
Chamber
is
a
member
of
the
EPA
FIFRA
Scientific
Advisory
Panel.

Dr.
Gary
Chadwick
Dr.
Gary
Chadwick
is
the
Associate
Provost
and
Director
of
the
Office
for
Human
Subject
Protection
at
the
University
of
Rochester
(
UR).
Dr.
Chadwick
holds
faculty
appointments
in
the
School
of
Medicine
and
Dentistry
(
SMD)
as
Clinical
Professor
of
Community
and
Preventive
Health
(
Health
Policy
and
Ethics)
and
Clinical
Professor
of
Medical
Humanities
(
Research
Ethics).
Since
arriving
at
the
University,
Dr.
Chadwick
has
been
active
in
teaching
research
ethics
to
graduate
and
medical
students,
serving
on
institutional
committees
for
Ethics
(
Clinical),
Conflict
of
Interest
(
both
for
SMD
as
well
University­
wide),
and
Compliance
(
UR).
Dr.
Chadwick's
former
research
interests
were
in
suicidology,
alcoholism,
drug
abuse
and
health
services
administration,
however,
his
current
research
activity
is
serving
as
an
ethics
consultant
(
unpaid)
on
some
federal
grants.

Before
joining
the
University
of
Rochester,
Dr.
Chadwick
was
a
commissioned
officer
in
the
U.
S.
Public
Health
Service
for
over
26
years.
He
served
in
the
Food
and
Drug
Administration
(
FDA)
where
he
was
the
Associate
Director
for
Human
Subject
Protection
in
the
Office
of
the
Commissioner
and
was
a
Senior
Scientific
Reviewer
in
the
Division
of
Scientific
Investigations
of
the
FDA's
Center
for
Drug
Evaluation
and
Research.
Dr.
Chadwick
has
also
worked
in
the
Office
for
Protection
from
Research
Risks
at
the
National
Institutes
of
Health.
He
is
a
Past
President
of
Applied
Research
Ethics
National
Association
(
ARENA).
He
was
the
founding
Chair
of
the
ARENA
Council
for
Certification
of
IRB
Professionals.
He
is
the
co­
author
of
the
widely
used
investigator
training
book,
"
Protecting
Study
Volunteers
in
Research."
Dr.
Chadwick
is
a
subcommittee
member
(
Subpart
A)
of
the
DHHS
Secretary's
Advisory
Committee
for
Human
Research
Protection.
He
earned
his
BS
in
Pharmacy
from
the
Ohio
State
University,
4
his
PharmD
from
the
University
of
Tennessee,
and
his
MPH
from
the
Uniformed
Services
University.

Dr.
Richard
Fenske
Dr.
Richard
A.
Fenske
is
Professor
of
Environmental
and
Occupational
Health
Sciences
at
the
University
of
Washington
(
UW)
and
director
of
the
NIOSH­
supported
Pacific
Northwest
Agricultural
Safety
and
Health
Center
since
its
establishment
in
1996.
He
is
a
core
faculty
member
of
the
NIEHS­
supported
Center
for
Ecogenetics
and
Environmental
Health.
He
also
served
as
Deputy
Director
of
the
EPA/
NIEHS­
supported
UW
Center
for
Child
Environmental
Health
Risks
Research
from
1998­
2003,
and
Director
of
the
UW
Field
Research
and
Consultation
Group
from
1992­
1996.
Dr.
Fenske
has
focused
his
research
on
the
assessment
and
mitigation
of
chemical
hazards
through
workplace
and
community
studies.
He
has
developed
new
procedures
for
the
assessment
of
skin
exposure
through
the
use
of
fluorescent
tracers.
He
has
also
contributed
to
the
elucidation
of
pesticide
exposure
pathways
for
children
living
in
agricultural
communities
and
in
residential
settings.
His
current
research
includes
studies
of
pesticide
spray
drift,
novel
biomonitoring
techniques,
and
para­
occupational
exposures
of
children
in
rural
communities.
He
currently
receives
research
support
from
the
NIOSH
Agricultural
Centers
Program,
the
EPA/
NIEHS
Children's
Environmental
Health
Centers
Program,
and
an
EPA
STAR
grant.

Dr.
Fenske
currently
serves
on
the
U.
S.
Environmental
Protection
Agency's
Science
Advisory
Board
(
Integrated
Human
Exposure
Committee),
and
is
also
a
member
of
the
National
Academy
of
Sciences/
Institute
of
Medicine
Committee
to
Review
the
Health
Effects
in
Vietnam
Veterans
of
Exposure
to
Herbicides.

From
1984­
1990
Dr.
Fenske
was
Assistant
Professor
and
then
Associate
Professor
of
Environmental
Sciences
at
Rutgers
University.
Prior
to
this
position,
he
received
his
doctoral
degree
and
master's
in
public
health
from
UC
Berkeley
in
Environmental
Health
Sciences.
He
was
also
awarded
a
master's
degree
in
geography
from
UC
Berkeley
and
a
master's
degree
in
comparative
religion
from
Columbia
University
in
New
York.
His
bachelor's
degree
was
in
history
from
Stanford
University.

Dr.
Celia
Fisher
Dr.
Celia
B.
Fisher
is
the
Marie
Ward
Doty
Professor
of
Psychology
and
Director
of
the
Fordham
University
Center
for
Ethics
Education.
Dr.
Fisher
is
a
member
of
the
DHHS
Secretary's
Advisory
Committee
on
Human
Research
Protections
(
SACHRP),
Co­
Chair
of
the
SACHRP
Subcommittee
on
Research
Involving
Children,
and
founding
editor
of
the
journal
Applied
Developmental
Science.
She
chaired
the
American
Psychological
Association's
(
APA)
Ethics
Code
Task
Force,
the
New
York
State
Board
for
Psychology,
the
Ethics
Committee
of
the
Society
for
Research
in
Child
Development,
and
the
National
Task
Force
on
Applied
Developmental
Science;
and
is
past
member
of
the
Ethics
Working
Group
of
the
National
Children's
Study,
the
NIMH
Data
Safety
and
Monitoring
Board,
and
the
Institute
of
Medicine
s
Committee
on
Clinical
Research
Involving
Children.
Dr
Fisher
is
author
of
Decoding
the
Ethics
Code:
A
Practical
Guide
for
Psychologists
(
Sage
Publications),
co­
editor
of
5
books
including
5
Ethical
Issues
in
Mental
Health
Research
with
Children
and
Adolescents
(
Erlbaum
Associates)
and
The
Handbook
of
Ethical
Research
with
Ethnocultural
Populations
and
Communities
(
Sage
Publications),
author
of
over
100
publications
in
the
areas
of
ethics
and
life­
span
development
and
of
commissioned
papers
for
the
President's
National
Bioethics
Advisory
Commission
on
relational
ethics
and
vulnerable
populations
and
on
the
ethics
of
suicide
research
for
NIMH.
With
support
from
NICHD
she
has
studied
how
to
assess
and
enhance
research
consent
capacity
of
adults
with
developmental
disabilities.
With
funding
from
NSF
and
NIH
she
has
developed
research
ethics
instructional
materials
for
undergraduates,
graduate
students,
senior
scientists,
and
IRBs
and
examined
parent­
child
perspectives
on
the
ethics
of
adolescent
risk
research.
Her
current
federally
funded
projects
include
Mentoring
the
Responsible
Conduct
of
Research
(
ORI/
NIAID),
Participant
Perspectives
on
Drug
Use
and
Related
HIV
Research
(
NIDA)
and
the
Fordham
Alcohol
Prevention
Program
(
NIAAA).
In
July
2001
she
co­
chaired
the
APA,
NIMH,
and
Fordham
Ethics
Center
sponsored
national
conference
on
Research
Ethics
for
Mental
Health
Science
Involving
Ethnic
Minority
Children
and
Youth
(
American
Psychologist,
December
2002).
In
2005
she
chaired
the
APA
meeting
on
Minimal
Risk
in
Social
Behavioral
Research
and
co­
chaired
the
Fordham
Summit
on
Biopharmaceuticals
for
the
21st
Century:
Responsibility,
Sustainability
&
Public
Trust.
She
has
developed
assessment
instruments
to
evaluate
how
teenagers
and
parents
from
different
racial/
ethnic
backgrounds
prepare
for
and
react
to
racial
discrimination,
examined
the
validity
of
child
abuse
assessment
techniques
in
institutional
and
forensic
settings,
and
family
attitudes
toward
involvement
of
adolescents
in
decisions
to
participate
in
pediatric
cancer
research.

Dr.
Susan
Fish
Dr.
Susan
Fish
is
Associate
Professor
of
Biostatistics
and
Epidemiology
at
the
Boston
University
School
of
Public
Health.
She
is
also
the
co­
director
of
the
MA
in
Clinical
Research
program
at
Boston
University
School
of
Medicine.
Dr.
Fish
received
her
Doctor
of
Pharmacy
degree
from
the
University
of
Minnesota
and
her
Masters
of
Public
Health
from
Boston
University,
as
well
as
a
Bachelor's
Degree
in
pharmacy
from
Massachusetts
College
of
Pharmacy
and
Allied
Health
Sciences
and
a
Bachelor's
Degree
in
chemistry
and
education
from
the
University
of
Massachusetts.

Dr.
Fish
previously
held
positions
as
Director
of
Human
Subjects
Protection
and
Associate
Director
of
the
Office
of
Clinical
Research
at
Boston
University
Medical
Center
(
BUMC),
Director
of
the
BUMC
Institutional
Review
Board
and
Director
of
Research
Participant
Safety
at
the
General
Clinical
Research
Center
at
Boston
University
School
of
Medicine.
She
has
also
served
as
Director
of
Regulatory
Affairs
at
CareStat,
Inc,
(
a
contract
research
organization)
and
as
Vice
Chair
for
Research
in
the
Department
of
Emergency
Medicine
at
Boston
City
Hospital/
Boston
Medical
Center
and
Associate
Professor
of
Emergency
Medicine
at
Boston
University
School
of
Medicine.
Prior
to
that,
she
was
Associate
Director
of
the
Massachusetts
Poison
Control
System
and
Associate
Professor
at
Massachusetts
College
of
Pharmacy
and
Allied
Health
Sciences.
Dr.
Fish
has
been
a
medical
researcher
for
more
than
20
years.
She
was
a
member
of
the
Human
Studies
Committee
at
Boston
City
Hospital/
Boston
Medical
Center
from
1989­
99
and
served
for
five
years
as
Associate
Chair
of
the
Committee.
On
the
national
level,
Dr.
Fish
is
an
active
member
of
many
organizations,
including
the
Society
for
Academic
Emergency
Medicine
and
PRIM&
R
(
Public
Responsibility
in
Medicine
and
Research)
where
she
6
serves
on
the
Board
of
Directors.
In
a
variety
of
forums,
Dr.
Fish
lectures
on
the
design,
conduct,
and
management
of
clinical
trials,
as
well
as
research
ethics
and
protection
of
human
research
subjects.
She
teaches
courses
at
the
Boston
University
Schools
of
Public
Health
and
Medicine,
and
is
frequently
an
invited
speaker
nationally.
Although
she
has
a
long
history
of
research
in
the
areas
of
clinical
toxicology
and
emergency
medicine,
Dr.
Fish
has
most
recently
focused
on
research
ethics
in
general,
and
application
of
the
federal
regulations
for
waiver
of
informed
consent
in
certain
emergency
research
circumstances.
Her
sabbatical
project
was
consistent
with
this
focus,
working
as
Project
Director
for
PRIM&
R's
Accreditation
Project
to
develop
a
national
accreditation
system
for
human
research
protection
programs.

Dr.
Suzanne
Fitzpatrick
Dr.
Suzanne
Fitzpatrick
is
a
Senior
Science
Policy
Analyst
in
the
Office
of
the
Commissioner,
Office
of
Science
and
Health
Coordination,
at
the
US
Food
and
Drug
Administration.
She
is
the
Human
Protection
Administrator
for
the
FDA
Institutional
Review
Board.
In
this
position,
she
drafted
the
Standard
Operating
Procedures
for
the
FDA
IRB
and
oversees
its
daily
activities.
She
is
also
working
on
the
oversight
program
for
quality
assurance
of
all
FDA
sponsored
research.
She
is
a
member
of
the
FDA
Human
Protection
Steering
Committee,
the
FDA
Human
Subjection
Protection/
Biomonitoring
Steering
Committee,
and
the
21
CFR
50.24
consultative
review
committee.
Dr.
Fitzpatrick
is
also
a
co­
investigator
on
an
FDA
grant
entitled
"
Pediatric
Assent
in
Adolescent
Research
Participants"
in
collaboration
with
NCI/
NIH
and
Walter
Reed
Army
Medical
Center.
Dr.
Fitzpatrick
is
the
FDA
National
Environmental
Protection
Act
(
NEPA)
liaison
to
the
Council
for
Environmental
Quality
at
the
White
House.
She
represents
FDA
on
several
Office
of
Science
and
Technology
Policy
Committees
(
OSTP)
including
the
CNER
Subcommittee
on
Toxics
and
Risk,
the
OSTP
Subcommittee
on
Health
and
the
Environment,
and
the
CNER
Subcommittee
on
Endocrine
Disruptors.
She
chairs,
with
EPA
and
USGS,
the
OSTP
Interagency
Working
Group
on
Human
and
Veterinary
Pharmaceutical
in
the
Environment,
whose
charge
is
to
leverage
research
strategies
in
this
area
across
the
different
federal
agencies.
Dr.
Fitzpatrick
is
also
a
member
of
the
Interagency
Committee
on
Validation
of
Alternative
Animal
Models.
Dr.
Fitzpatrick
is
a
board
certified
toxicologist.
She
is
the
past
president
of
the
American
College
of
Toxicology
and
also
a
past
member
of
its
board
of
councilors.
Currently
Dr,
Fitzpatrick
is
the
President
Elect
of
the
Nation's
Capital
Chapter
of
the
Society
of
Toxicology
(
SOT),
a
Councilor
for
the
Regulatory
and
Safety
Specialty
Section
of
and
a
member
of
the
K­
12
SOT
Education
Committee.
She
is
also
an
adjunct
professor
at
Johns
Hopkins
University,
Zanvyl
Krieger
School
of
Arts
and
Science.
Dr.
Fitzpatrick
received
her
BA
from
the
University
of
California
at
San
Diego
and
her
PhD
from
Georgetown
University.

Dr.
Kannan
Krishnan
Dr.
Kannan
Krishnan
received
his
Ph.
D.
in
Public
Health
from
Université
de
Montréal,
Canada
and
postdoctoral
training
from
the
Chemical
Industry
Institute
of
Toxicology
(
CIIT),
Research
Triangle
Park,
North
Carolina.
He
is
currently
Professor
of
Occupational
and
Environmental
Health
and
Director
of
the
Human
Toxicology
research
group
(
TOXHUM)
at
Université
de
Montréal.
He
has
been
the
leader
of
the
risk
assessment
methodologies
theme
team
of
the
Canadian
Network
of
Toxicology
Centers
(
1994
 
2001),
and
Vice
President
of
the
Biological
Modeling
Specialty
Section
of
the
Society
of
Toxicology
(
2001­
02).
A
member
of
the
U.
S.
National
Academy
of
7
Sciences
(
NAS)
Sub­
committee
on
Acute
Exposure
Guideline
Levels
(
2001­
2004),
Dr.
Krishnan
is
currently
the
president
of
the
Risk
Assessment
Specialty
Section
of
the
Society
of
Toxicology
and
a
temporary
advisor
for
the
World
Health
Organization.
His
expertise
is
in
the
areas
of
general
toxicology,
pharmacokinetics,
physiologically­
based
modeling,
chemical
mixtures
and
health
risk
assessment
methods.
He
has
been
a
peer
reviewer
of
several
risk
assessments,
mixture
risk
assessment
supplemental
guidance
and
efforts
on
interactions
for
U.
S.
EPA.
He
has
also
been
involved
as
a
reviewer
of
toxicological
profiles
of
chemicals
and
interaction
profiles
for
chemical
mixtures
produced
by
ATSDR.
An
author
of
a
text
book
on
environmental
pollution,
Dr.
Krishnan
has
authored
or
co­
authored
over
100
full­
length
publications
in
the
areas
of
human
health
risk
assessment,
pharmacokinetics
and
its
determinants
in
humans,
chemical
interactions
in
rodents
and
humans
as
well
as
computational
toxicology.
He
has
served
on
the
editorial
boards
of
Toxicological
Sciences,
International
Journal
of
Toxicology,
Journal
of
Applied
Toxicology
and
Journal
of
Child
Health.
In
the
year
2000,
he
received
the
Veylian
Henderson
Award
from
the
Society
of
Toxicology
of
Canada
for
significant
contributions
to
the
field
of
toxicology
in
Canada
and
was
co­
recipient
of
the
Best
paper
award
(
2003)
from
the
Board
of
Publications
of
the
Society
of
Toxicology.

Dr.
Krishnan's
current
research
projects
are
funded
by
the
Natural
Sciences
and
Engineering
Research
Council
of
Canada.
Past
funding
sources
include
Quebec
Health
Research
Council,
Canadian
Network
of
Toxicology
Centers,
Health
Canada
and
Ethylbenzene
Panel
of
American
Chemistry
Council.

Dr.
Kyung
Mann
Kim
Dr.
Kim
is
Professor
of
Biostatistics
and
Statistics
and
Associate
Chair
of
the
Department
of
Biostatistics
and
Medical
Informatics
at
the
University
of
Wisconsin­
Madison
and
Director
of
Biostatistics
Shared
Resource
at
the
University
of
Wisconsin
Comprehensive
Cancer
Center.
Prior
to
his
current
appointment,
he
was
Assistant
Professor
(
1988­
1994)
and
Associate
Professor
(
1994­
1995)
of
Biostatistics
at
Harvard
University
and
Dana­
Farber
Cancer
Institute,
Associate
Professor
of
Biostatistics
at
the
University
of
Michigan
in
Ann
Arbor,
MI
and
Director
of
Biostatistics
at
the
University
of
Michigan
Comprehensive
Cancer
Center
(
1995­
1997),
and
Visiting
Associate
Professor
of
Ophthalmology
at
Johns
Hopkins
University
(
1995).
Dr.
Kim
is
recognized
nationally
and
internationally
for
his
contributions
in
statistical
methods
for
interim
analysis
in
clinical
trials
and
clustered
and
repeated
measures
analysis
and
in
clinical
oncology
research
and
has
published
extensively
in
statistical
methods
for
clinical
trials
and
in
cancer
clinical
trials.
He
is
Co­
chair
of
the
Protocol
Review
and
Monitoring
Committee
and
the
Data
and
Safety
Monitoring
Committee
of
the
University
of
Wisconsin
Comprehensive
Cancer
Center,
reviewing
the
scientific
merit
of
clinical
trial
protocols,
the
safety
of
participants,
and
the
scientific
validity
of
data.
He
was
a
member
of
the
Lung
Cancer
Concept
Evaluation
Panel,
Division
of
Cancer
Treatment
and
Diagnosis,
National
Cancer
Institute
(
NCI)
(
1999­
2002)
and
a
member
of
Subcommittee
E
on
Cancer
Epidemiology,
Prevention
and
Control,
NCI
Initial
Review
Group
(
2001­
2005).
He
was
a
member
of
the
Autoimmune
Diseases
Data
and
Safety
Monitoring
Board,
National
Institute
of
Allergy
and
Infectious
Diseases
(
NIAID)
(
2000­
2004)
and
has
been
serving
as
member
of
the
HIV/
AIDS
Therapeutic
Trials
Data
and
Safety
Monitoring
Board,
NIAID
since
1998.
These
activities
all
relate
to
human
studies
review
and
ongoing
review
and
monitoring
of
participant
safety
and
study
scientific
validity
in
clinical
trials.
8
Dr.
Kim
was
elected
member
of
the
Regional
Committee
of
the
Eastern
North
American
Region
(
ENAR)
of
the
International
Biometrics
Society
and
ENAR
representative
to
the
Biological
Sciences
Section
of
the
American
Association
for
Advancement
of
Science.
He
is
an
Associate
Editor
for
Biometrics,
an
official
journal
of
the
International
Biometric
Society.
He
served
as
Founding
Chair
of
the
National
Working
Group
of
Cancer
Center
Biostatistics
Directors
during
1996­
2003.
He
is
Chair
of
the
Program
Committee
for
the
Annual
Meeting
of
the
Society
for
Clinical
Trials
in
2006.
He
is
a
Fellow
of
the
American
Statistical
Association.
Dr.
Kim
received
his
Bachelor
of
Science
(
B.
S.)
degree
in
Computer
Science
and
Statistics
in
1978
and
Master
of
Science
(
M.
S.)
degree
in
Statistics
in
1980,
both
from
Seoul
National
University,
Seoul,
Korea
and
Doctor
of
Philosophy
(
Ph.
D.)
degree
in
Statistics
from
the
University
of
Wisconsin­
Madison
in
1985.

Dr.
Lois
Lehman­
McKeeman
Dr.
Lois
Lehman­
McKeeman
is
currently
a
Distinguished
Research
Fellow
in
Discovery
Toxicology
at
the
Bristol­
Myers
Squibb
Company
in
Princeton,
NJ.
She
received
a
BS
degree
in
Toxicology
from
the
Philadelphia
College
of
Pharmacy
&
Science
and
holds
a
Ph.
D.
in
Toxicology
from
the
University
of
Kansas
Medical
Center.
She
was
employed
in
the
Human
and
Environmental
Safety
Division
of
the
Procter
and
Gamble
Company
for
15
years
prior
to
joining
Bristol
Myers
Squibb
in
2001.
Lois
has
active
research
interests
and
programs
broadly
in
mechanisms
of
toxicity,
with
emphasis
on
secondary
mechanisms
of
carcinogenesis.
She
is
also
working
to
develop
and
apply
metabonomic
and
transcriptomic
technologies
to
mechanistic
toxicology.
She
has
been
active
professionally
in
the
Society
of
Toxicology
(
SOT)
serving
on
numerous
SOT
committees,
and
she
held
elective
office
in
the
SOT
as
Councilor
from
2000­
2002.
In
2003
she
was
appointed
Editor
of
Toxicological
Sciences,
a
position
she
currently
holds,
and
she
serves
on
a
number
of
other
editorial
boards.
She
has
or
is
presently
sitting
on
a
variety
of
national
and
international
advisory
committees
for
EPA,
NIH,
IARC
and
IPCS.
She
is
a
fellow
in
the
Academy
of
Toxicological
Sciences,
and
she
was
the
recipient
of
the
Robert
Scala
Award
in
Toxicology
for
research
excellence
in
an
industrial
laboratory
in
1994
and
the
Society
of
Toxicology
Achievement
Award
in
2003.

Dr.
Michael
Lebowitz
Michael
Lebowitz
has
a
Ph.
D.
in,
Epidemiology
&
International
Health,
and
Environmental
Health
Sciences
(
with
minors
in
Sociology
and
Biostatistics),
and
a
Ph.
C.
in
Preventive
Medicine
(
with
a
minor
in
Biomedical
Sciences)
from
the
University
of
Washington
(
Seattle).
He
also
has
an
MA
in
Biostatistics
(
with
a
minor
in
Demography)
and
a
BA
in
Psychology
from
the
University
of
California
(
Berkeley).
He
completed
his
clinical
training
in
cardio­
pulmonary
medicine
at
the
University
of
London
Postgraduate
Cardio­
thoracic
Institute.
He
started
in
public
health
in
1962,
and
worked
in
both
county
and
state
health
departments
in
Epidemiology
and
Biostatistics.
His
areas
of
expertise
are
community­
based
prevention/
intervention
research,
chronic
&
infectious
disease
epidemiology,
and
environmental­
occupational
medicine.
He
is
a
fellow
of
the
American
College
of
Chest
Physicians,
the
American
College
of
Epidemiology,
and
the
Collegium
Ramazzini.
He
is
an
elected
member
of
the
International
Academy
of
Indoor
Air
Sciences,
the
American
Epidemiological
Society,
the
International
Epidemiological
Association,
Delta
Omega
(
the
honorary
public
health
society),
and
as
an
honorary
member
of
the
Hungarian
Society
of
Hygiene.
He
is
a
founding
member
of
the
International
Society
of
9
Exposure
Analysis
(
ISEA)
and
the
International
Society
of
Environmental
Epidemiology,
and
a
charter
member
the
Society
of
Epidemiological
Research.
He
has
been
a
member
of
other
medical
and
scientific
societies.
He
is
a
past
President
of
ISEA
and
recipient
of
its
highest
award,
and
is
past
Chair
of
the
national
prevention
research
centers
national
program.
He
has
been
received
various
honors
and
awards
from
The
University
of
Arizona
College
of
Public
Health
and
Graduate
College.
He
has
been
Principal
Investigator
(
PI)
of
many
grants
and
is
currently
the
PI
of
a
CDC
Prevention
Research
Center
and
Border
Vision
Fronteriza
(
HRSA),
and
is
Co­
PI
of
a
Legacy
Foundation
grant
and
an
NIH­
NHLBI
grant.
Dr.
Lebowitz
has
served
on
the
EPA
Science
Advisory
Board,
on
National
Academy
of
Sciences
(
NRC­
NAS/
IOM)
committees,
and
has
been
a
consultant
and
peer­
reviewer
for
EPA,
NIH,
NIOSH
and
other
agencies
for
over
30
years.
He
has
also
served
as
member/
chair
of
committees
for
WHO,
PAHO,
and
UNEP.
He
has
been
an
expert
consultant
and
witness
for
state
and
federal
government
agencies,
various
NGOs
and
CBOs.
He
has
over
400
peer­
reviewed
publications.

Dr.
Jerry
Menikoff
Dr.
Jerry
Menikoff
is
Associate
Professor
of
Law,
Ethics
&
Medicine
and
Director
of
the
Institute
for
Bioethics,
Law
and
Public
Policy
at
the
University
of
Kansas
School
of
Medicine.
Since
1998
he
has
served
as
chairperson
of
the
Institutional
Review
Board
at
that
institution.
He
is
also
currently
Medical
Director
of
Hospital
Ethics
at
the
University
of
Kansas
Hospital,
and
an
Associate
Professor
of
Law
at
the
University
of
Kansas
School
of
Law.
He
received
his
undergraduate
degree
from
Harvard
University
(
magna
cum
laude
in
Mathematics,
1973),
and
also
received
in
1977
a
J.
D.
(
magna
cum
laude;
Editor
and
Officer
of
the
Harvard
Law
Review)
and
M.
P.
P.
(
Public
Policy)
from
Harvard.
Dr.
Menikoff
earned
an
M.
D.
in
1986
from
Washington
University
(
St.
Louis).
He
served
as
a
judicial
clerk
to
the
Honorable
Irving
R.
Kaufman,
Chief
Judge,
United
States
Court
of
Appeals
for
the
Second
Circuit,
and
has
been
a
faculty
fellow
at
the
MacLean
Center
for
Clinical
Medical
Ethics
at
the
University
of
Chicago,
and
at
the
Center
for
Ethics
and
the
Professions
at
Harvard
University.

For
the
past
several
years,
Dr.
Menikoff's
research
interests
have
concentrated
on
bioethics
in
general,
and
more
particularly
on
the
ethics
of
research
with
human
subjects.
His
widely
used
textbook
Law
and
Bioethics:
An
Introduction
(
Georgetown
University
Press
2001)
is
now
in
its
second
printing,
and
was
chosen
in
2002
by
the
Association
of
American
University
Presses
as
one
of
"
The
Best
of
the
Best
from
the
University
Presses:
Books
You
Should
Know
About."
He
is
a
coauthor
of
the
recently
published
textbook
(
and
accompanying
teacher's
manual),
The
Ethics
and
Regulation
of
Research
with
Human
Subjects
(
LexisNexis
2005).
His
newest
book,
providing
an
evaluation
of
how
the
United
States
regulates
research
with
human
subjects,
will
be
published
in
2006
by
Oxford
University
Press.
He
has
on
a
number
of
recent
occasions
been
hired
as
a
consultant
by
the
federal
Office
for
Human
Research
Protections,
and
was
one
of
the
eight
panelists
convened
by
that
agency
to
review
the
controversial
issues
raised
by
the
ARDS
Network
studies
(
see
Jeffrey
M.
Drazen,
Controlling
Research
Trials,
New
Engl.
J.
Med.
2003;
348:
1377­
80).
He
has
recently
written
about
the
issues
that
led
to
the
creation
of
the
EPA
Human
Studies
Review
Board
in
Of
Babies,
Bugs,
and
Bombast:
A
Look
Behind
the
Crash­
and­
Burn
of
the
CHEERS
Pesticide
Study,
4(
14)
Medical
Research
Law
&
Policy
Report
586
(
BNA)
(
July
20,
2005),
and
is
a
member
of
the
Advisory
Board
for
the
Medical
Research
Law
&
Policy
Report.
10
Dr.
Robert
M.
Nelson
Dr.
Robert
M.
Nelson
is
Associate
Professor
of
Anesthesiology
and
Critical
Care
at
The
Children's
Hospital
of
Philadelphia
(
CHOP)
and
the
University
of
Pennsylvania
School
of
Medicine.
After
receiving
his
MD
degree
from
Yale
University
in
1980,
Dr.
Nelson
trained
in
pediatrics
(
Massachusetts
General
Hospital),
neonatology
and
pediatric
critical
care
(
University
of
California,
San
Francisco).
He
has
received
formal
training
in
theology,
religious
and
medical
ethics,
receiving
a
Master
of
Divinity
degree
from
Yale
Divinity
School
in
1980
and
a
Ph.
D.
in
The
Study
of
Religion
from
Harvard
University
in
1993.
Dr.
Nelson
has
lectured
and
published
widely
on
ethical
and
regulatory
issues
in
pediatric
research
and
clinical
care.
Dr.
Nelson
is
Chair
of
the
Pediatric
Advisory
Committee
(
PAC)
of
the
Food
and
Drug
Administration,
and
former
Chair
of
the
PAC
Pediatric
Ethics
Subcommittee.
He
also
serves
as
a
member
of
the
Subcommittee
on
Research
Involving
Children
of
the
DHHS
Secretary's
Advisory
Committee
on
Human
Research
Protections.
Dr.
Nelson
was
a
member
of
the
Committee
on
Clinical
Research
Involving
Children
of
the
Institute
of
Medicine
(
through
March
2004),
and
former
Chair
of
the
Committee
on
Bioethics
of
the
American
Academy
of
Pediatrics
(
through
2001).
Currently
he
is
Director
of
the
Center
for
Research
Integrity,
established
at
CHOP
to
further
the
responsible
conduct
of
pediatric
research.
Dr.
Nelson's
current
research
explores
different
aspects
of
child
assent
and
parental
permission
such
as
adolescent
risk
perception,
the
development
of
a
child's
capacity
to
assent,
and
the
degree
to
which
parental
choice
is
perceived
as
voluntary.
His
research
has
been
funded
by
the
National
Institutes
of
Health,
the
Greenwall
Foundation
and
The
National
Science
Foundation.

Dr.
Sean
Philpott
Dr.
Sean
Philpott
is
a
tenured
Research
Scientist
(
Assoc.
Research
Professor)
in
the
Department
of
Infectious
Disease
at
the
New
York
State
Department
of
Health,
an
Adjunct
Professor
in
the
Department
of
Biomedical
Sciences
of
the
University
at
Albany
School
of
Public
Health,
and
is
the
Executive
Managing
Editor
of
the
American
Journal
of
Bioethics.
He
serves
on
the
New
York
State
Department
of
Health
Institutional
Review
Board
and
is
a
member
of
the
New
York
Working
Group
on
Bioethics.
He
is
involved
in
a
Fogarty
Institute­
funded
project
to
teach
research
ethics
to
Central
and
Eastern
European
scientists,
physicians,
lawyers
and
other
professionals.
Dr.
Philpott
also
serves
as
consultant
to
various
governmental
and
nongovernmental
bodies,
such
as
the
Forum
for
Collaborative
HIV
Research.

He
received
his
undergraduate
degrees
in
biology
and
medical
anthropology
from
the
University
of
California
at
San
Diego,
and
completed
his
Ph.
D.
in
Microbiology
at
the
University
of
California
at
Berkeley.
In
addition
to
his
on­
going
laboratory
studies
of
HIV
pathogenesis,
Dr.
Philpott
is
particularly
interested
in
the
ethical
issues
associated
with
biomedical
research,
including
the
protection
of
human
subjects
in
industrialized
and
developing
countries
and
the
management
of
conflicts
of
interest
in
academia.

Dr.
Richard
Sharp
Dr.
Richard
R.
Sharp
(
Ph.
D.
Philosophy,
Michigan
State
University,
1999)
is
an
Assistant
Professor
of
Medicine
with
the
Center
for
Medical
Ethics
and
Health
Policy,
Baylor
College
of
Medicine
(
BCM).
Dr.
Sharp's
professional
interests
center
on
ethical
issues
in
biomedical
11
research
and
genetics.
He
has
written
on
ethical
considerations
in
testing
asymptomatic
persons
for
genetic
predispositions
to
disease,
understandings
of
race
and
ethnicity
in
genomic
research,
and
the
identification
of
genetic
sensitivities
to
environmental
toxicants.
Dr.
Sharp
is
the
principle
investigator
for
several
ongoing
research
projects,
including:
1)
Indian
and
Hindu
perspectives
on
genetic
variation
research,
2)
Patient
attitudes
regarding
the
collection
and
use
of
biological
materials
for
genomic
research,
3)
Patient
perspectives
on
the
role
of
consumer
advocacy
groups,
and
4)
Ethical,
legal,
and
social
issues
in
toxicogenomic
research.
Dr.
Sharp
directs
the
fourth
course
in
the
BCM
Ethics
Track,
Research
in
Clinical
Medical
Ethics,
and
participates
in
the
teaching
of
clinical
ethics
to
medical
students,
residents,
and
clinical
fellows
at
Ben
Taub
General
Hospital
and
The
Methodist
Hospital.
He
also
lectures
on
topics
in
research
ethics
in
the
Clinical
Scientist
Training
Program
and
the
Research
Ethics
Symposium,
a
training
program
on
research
conduct
for
clinical
fellows,
post­
doctoral
fellows,
and
graduate
students
in
the
biological
sciences.
Dr.
Sharp
coordinates
Ethics
Grand
Rounds
for
The
Methodist
Hospital
and
serves
on
their
Ethics
Committee.
Dr.
Sharp
has
served
on
advisory
committees
for
the
American
Thoracic
Society,
the
European
Respiratory
Society,
the
Alpha
One
Foundation,
the
Woodrow
Wilson
Center,
and
the
National
Institutes
of
Health.
Before
joining
the
Center
in
2002,
Dr.
Sharp
worked
as
a
Biomedical
Ethicist
at
the
National
Institute
of
Environmental
Health
Sciences
where
he
directed
the
Program
in
Environmental
Health
Policy
and
Ethics.