Document ID: EPA-HQ-OPP-2011-0885-0075
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2017-11-02T04:00Z

Meeting Summary
On Friday, October 13, 2017, U.S. EPA's Office of Pesticide Programs (OPP), Divisions of Pesticide Reevaluation (PRD) and Health Effects (HED), met--via teleconference--with representatives of the Pyrethrin Joint Venture (PJV) and researchers from the Pyrethrins Stewardship Program (PSP) to discuss the findings of the PSP final report.  The PSP report was developed by the PJV as a condition of the 2006 Pyrethrins Reregistration Eligibility Decision to explore incidents of pyrethrin-containing product exposures reported with a special emphasis on adverse reactions to individuals with allergies or asthma.

The lead authors and researchers of the PSP report provided OPP with an overview of the final report, using the topics and questions posed in Section D as a template for discussion.  OPP provided PJV/PSP with a history of OPP's interest in exposure incidents to pyrethrin-containing products in the U.S. population and potential adverse effects to exposed individuals with medical conditions or predisposition such as asthma, allergies, and smoking.  During the discussion OPP and PJV/PSP developed several action items for their respective organizations which are detailed below in Section C. OPP will review the PSP final report -- as well as previously submitted status reports -- along with the corresponding data as part of OPP's Registration Review of pyrethrins.  
   
 Meeting Attendees 
OPP's Pesticide Reevaluation Division: Mark Baldwin, Jill Bloom, Linda Arrington 
OPP's Health Effects Division:  David Miller, Aaron Niman, James Nguyen, Shanna Recore
Pyrethrin Joint Venture: Hannah Alleman, Jonathan Berger, Steve Ditto, Janelle Kay, Steve Klaysmat, Jean Killoren, Jim Olson, and Ellen Thom.
Pyrethrin Stewardship Program Consultants: Tom Osimitz (Science Strategies), Rick Kingston (SafetyCall), and Angie Carlson (Data IQ) 
   
 Action Items
 (Completed) OPP would provide a list of missing data fields in the final PSP report and supplemental data to the PJV/PSP.  The missing data fields were provided to the PJV representative Hannah Alleman for distribution.  
 (Completed) OPP would provide the PJV/PSP with relevant research articles to the National Institutes of Health, Agricultural Research Studies focused on -- among other things--health effects to farmers from pesticide exposure, which includes pyrethrins. This was provided to Hannah Alleman of the PJV for distribution.   
 The PSP authors/researchers offer to make OPP aware of the publication of a pending peer review journal article based on the "Association Score" methodology used in the PSP final report.

 EPA's Suggested Topics and Questions for PSP/PJV 
 A discussion of the rationales behind PSP's conclusions (i.e., no label changes warranted, relative low number of incidents to pyrethrins, most outcomes are minor and self-limiting, and pyrethrins containing products do not pose a significant risk of serious dermal or respiratory reactions to individuals with asthmas or allergies). 
 A discussion on the comparative differences of the Phase III population against U.S. general population for a study like this (i.e., relatively high number of individuals classified as smokers and asthmatic). 
 A more detail discussion of SafetyCall's association score. 
 A discussion of the study's findings on foggers and aerosol products.