Document ID: EPA-HQ-OPP-2005-0495-0031
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2006-07-05T04:00Z

United
States
Prevention,
Pesticides
EPA
738­
R­
06­
007
Environmental
Protection
and
Toxic
Substances
2006
Agency
(
7508C)
OPP­
2005­
0495
Reregistration
Eligibility
Decision
for
Imazapyr
Reregistration
Eligibility
Decision
(
RED)
Document
for
Imazapyr
List
C
Case
Number
3078
Approved
by:
Date:
Debra
Edwards,
Ph.
D.
Director
Special
Review
and
Reregistration
Division
i
Table
of
Contents
Imazapyr
Reregistration
Eligibility
Decision
Team
...................................................
iii
Glossary
of
Terms
and
Abbreviations.........................................................................
iv
Abstract
.........................................................................................................................
1
I.
Introduction
...............................................................................................................
2
II.
Chemical
Overview..................................................................................................
3
A.
Chemical
Background
..........................................................................................
3
B.
Imazapyr
Acid
and
Salt
Nomenclature................................................................
4
C.
Use
Sites
................................................................................................................
4
D.
Formulations.........................................................................................................
4
E.
Methods
of
Application
........................................................................................
5
F.
Use
rates
................................................................................................................
5
G.
Annual
usage
........................................................................................................
5
H.
Technical
Registrant
............................................................................................
5
III.
Summary
of
Risk
Assessment
................................................................................
5
A.
Human
Health
Risk
Assessment
..........................................................................
6
1.
Hazard
Profile
...................................................................................................
6
2.
Dietary
Risk
(
Food)
...........................................................................................
9
a.
Acute
Dietary
Risk
(
Food)..............................................................................
10
b.
Chronic
Dietary
Risk
(
Food)..........................................................................
10
3.
Cancer
Dietary
Risk
(
Food)
............................................................................
10
4.
Drinking
Water
Dietary
Exposure..................................................................
11
5.
Chronic
Risk
from
Food
and
Drinking
Water
...............................................
12
6.
Residential
Risk
...............................................................................................
12
a.
Residential
Handler
Summary.......................................................................
13
b.
Residential
Post­
application
Summary
.........................................................
13
c.
Combined
Post­
application
Residential
Summary........................................
13
d.
Recreational
Uses
...........................................................................................
14
7.
Aggregate
Risk.................................................................................................
14
8.
Occupational
Risk
...........................................................................................
14
a.
Occupational
Handler
Summary
...................................................................
15
b.
Post­
application
Occupational
Risk...............................................................
15
9.
Incident
Reports
..............................................................................................
16
B.
Ecological
Risk
Assessment
................................................................................
16
1.
Environmental
Fate
and
Transport
................................................................
17
2.
Ecological
Risk
Assessment.............................................................................
17
a.
Plant
Toxicity..................................................................................................
19
b.
Terrestrial
Plant
Risk.....................................................................................
19
c.
Aquatic
Plant
Risk..........................................................................................
22
3.
Incident
Reports
..............................................................................................
23
4.
Endangered
Species
Risk
................................................................................
23
IV.
Risk
Management,
Reregistration,
and
Tolerance
Reassessment
Decision........
24
A.
Determination
of
Reregistration
Eligibility
.......................................................
24
B.
Public
Comments
and
Responses
.......................................................................
25
C.
Regulatory
Position
............................................................................................
26
1.
Food
Quality
Protection
Act
Findings
............................................................
26
a.
"
Risk
Cup"
Determination
............................................................................
26
ii
b.
Endocrine
Disruptor
Effects
..........................................................................
27
c.
Cumulative
Risks
............................................................................................
27
2.
Tolerance
Summary
........................................................................................
27
a.
Tolerances
Currently
Listed
and
Tolerance
Reassessment
..........................
29
D.
Regulatory
Rationale..........................................................................................
30
1.
Human
Health
Risk
Management
..................................................................
30
a.
Occupational
Risk
Mitigation
........................................................................
30
2.
Environmental
Risk
Management
..................................................................
31
a.
Non­
target
Terrestrial
Plant
Risk
Mitigation................................................
31
b.
Non­
target
Aquatic
Plant
Risk
Mitigation
....................................................
32
3.
Significance
of
Imazapyr
Use
..........................................................................
33
4.
Other
Labeling
Requirements.........................................................................
33
5.
Threatened
and
Endangered
Species
Considerations
....................................
33
a.
The
Endangered
Species
Program.................................................................
33
b.
General
Risk
Mitigation.................................................................................
34
V.
What
Registrants
Need
to
Do.................................................................................
34
A.
Manufacturing
Use
Products
.............................................................................
34
1.
Additional
Generic
Data
Requirements..........................................................
34
2.
Labeling
for
Technical
and
Manufacturing
Use
Products.............................
35
B.
End­
Use
Products
...............................................................................................
35
1.
Additional
Product­
Specific
Data
Requirements
...........................................
35
2.
Labeling
for
End­
Use
Products.......................................................................
36
a.
Label
Changes
Summary
Table
.....................................................................
36
VI.
Appendices
............................................................................................................
43
Appendix
A.
IMAZAPYR
USE
PATTERNS
ELIGIBLE
FOR
REREGISTRATION
..............................................................................................
44
Appendix
B.
TABLE
OF
GENERIC
DATA
REQUIREMENTS
AND
STUDIES
USED
TO
MAKE
THE
REREGISTRATION
DECISION...................................
47
Appendix
C.
Technical
Support
Documents
.........................................................
57
Appendix
D.
CITATIONS
CONSIDERED
TO
BE
PART
OF
THE
DATA
BASE
SUPPORTING
THE
REREGISTRATION
DECISION
(
BIBLIOGRAPHY)
.....
58
Appendix
E.
GENERIC
DATA
CALL­
IN
............................................................
89
Appendix
F.
PRODUCT
SPECIFIC
DATA
CALL­
IN
........................................
90
Appendix
G.
EPA'S
BATCHING
OF
IMAZAPYR
PRODUCTS
FOR
MEETING
ACUTE
TOXICITY
DATA
REQUIREMENTS
FOR
REREGISTRATION
..............................................................................................
91
Appendix
H.
LIST
OF
REGISTRANTS
SENT
THIS
DATA
CALL­
IN
NOTICE
..................................................................................................................................
95
Appendix
I.
LIST
OF
AVAILABLE
RELATED
DOCUMENTS
AND
ELECTRONICALLY
AVAILABLE
FORMS
......................................................
96
iii
Imazapyr
Reregistration
Eligibility
Decision
Team
Special
Review
and
Reregistration
Division
Sherrie
L.
Kinard
Eric
Olson
Robert
McNally
Health
Effects
Division
David
Anderson
Yvonne
Barnes
Sherrie
L.
Kinard
Charles
(
Billy)
Smith
Christina
Jarvis
William
Hazel
Environmental
Fate
and
Effects
Division
Pamela
Hurley
Stephan
Carey
Lucy
Shanaman
Biological
and
Economic
Analysis
Division
Bill
Phillips
TJ
Wyatt
Registration
Division
Jim
Tompkins
iv
Glossary
of
Terms
and
Abbreviations
AGDCI
Agricultural
Data
Call­
In
ai
Active
Ingredient
aPAD
Acute
Population
Adjusted
Dose
BCF
Bioconcentration
Factor
CFR
Code
of
Federal
Regulations
cPAD
Chronic
Population
Adjusted
Dose
CSF
Confidential
Statement
of
Formulation
CSFII
USDA
Continuing
Surveys
for
Food
Intake
by
Individuals
DCI
Data
Call­
In
DEEM
Dietary
Exposure
Evaluation
Model
DFR
Dislodgeable
Foliar
Residue
DNT
Developmental
Neurotoxicity
EC
Emulsifiable
Concentrate
Formulation
EDWC
Estimated
Drinking
Water
Concentration
EEC
Estimated
Environmental
Concentration
EPA
Environmental
Protection
Agency
EUP
End­
Use
Product
FDA
Food
and
Drug
Administration
FIFRA
Federal
Insecticide,
Fungicide,
and
Rodenticide
Act
FFDCA
Federal
Food,
Drug,
and
Cosmetic
Act
FQPA
Food
Quality
Protection
Act
GLN
Guideline
Number
IR
Index
Reservoir
LC50
Median
Lethal
Concentration.
A
statistically
derived
concentration
of
a
substance
that
can
be
expected
to
cause
death
in
50%
of
test
animals.
It
is
usually
expressed
as
the
weight
of
a
substance
per
weight
or
volume
of
water,
air,
or
feed,
e.
g.,
mg/
l,
mg/
kg,
or
ppm.
LD50
Median
Lethal
Dose.
A
statistically
derived
single
dose
that
can
be
expected
to
cause
death
in
50%
of
the
test
animals
when
administered
by
the
route
indicated
(
oral,
dermal,
inhalation).
It
is
expressed
as
a
weight
of
substance
per
unit
weight
of
animal,
e.
g.,
mg/
kg.
LOC
Level
of
Concern
LOAEL
Lowest
Observed
Adverse
Effect
Level
MATC
Maximum
Acceptable
Toxicant
Concentration
µ
g/
g
Micrograms
Per
Gram
µ
g/
L
Micrograms
Per
Liter
mg/
kg/
day
Milligram
Per
Kilogram
Per
Day
mg/
L
Milligram
Per
Liter
MOE
Margin
of
Exposure
MRID
Master
Record
Identification
Number.
EPA
'
s
system
for
recording
and
tracking
studies
submitted.
MUP
Manufacturing­
Use
Product
NOAEL
No
Observed
Adverse
Effect
Level
OPP
EPA
Office
of
Pesticide
Programs
OPPTS
EPA
Office
of
Prevention,
Pesticides,
and
Toxic
Substances
PAD
Population
Adjusted
Dose
PCA
Percent
Crop
Area
PDP
USDA
Pesticide
Data
Program
PHED
Pesticide
Handler's
Exposure
Data
PHI
Pre­
harvest
Interval
ppb
Parts
Per
Billion
PPE
Personal
Protective
Equipment
ppm
Parts
Per
Million
PRZM/
EXAMS
Tier
II
Surface
Water
Computer
Model
RAC
Raw
Agriculture
Commodity
v
RED
Reregistration
Eligibility
Decision
REI
Restricted
Entry
Interval
RfD
Reference
Dose
RQ
Risk
Quotient
SCI­
GROW
Tier
I
Ground
Water
Computer
Model
SAP
Science
Advisory
Panel
SF
Safety
Factor
SLC
Single
Layer
Clothing
TGAI
Technical
Grade
Active
Ingredient
USDA
United
States
Department
of
Agriculture
USGS
United
States
Geological
Survey
UF
Uncertainty
Factor
UV
Ultraviolet
WPS
Worker
Protection
Standard
1
Abstract
This
document
presents
the
Environmental
Protection
Agency's
(
hereafter
referred
to
as
EPA
or
the
Agency)
decision
regarding
the
reregistration
eligibility
of
the
registered
uses
of
imazapyr.
The
Agency
has
determined
that
imazapyr­
containing
products
are
eligible
for
reregistration,
provided
that
the
risk
mitigation
measures
identified
in
this
document
are
adopted
and
label
amendments
are
made
to
reflect
these
measures.
Imazapyr
is
a
systemic,
non­
selective
herbicide
used
for
the
pre­
and
postemergence
control
of
a
broad
range
of
terrestrial
and
aquatic
weeds.
There
are
currently
twenty­
four
tolerances
established
in
40
CFR
§
180.500
for
residues
of
the
herbicide
imazapyr,
applied
as
the
acid
or
ammonium
salt
which
were
reassessed
in
2003
when
new
food
uses
were
established.
The
Agency
has
conducted
human
health
and
environmental
fate
and
ecological
effect
risk
assessments
for
imazapyr
and
reassessed
all
the
existing
tolerances.
The
risk
conclusions
of
these
assessments
are
summarized
below.

In
the
human
health
risk
assessment,
dietary
risks
(
food
and
drinking
water)
are
below
the
Agency's
level
of
concern.
Residential
handler
dermal
and
inhalation
risks
for
all
scenarios
are
below
the
Agency's
level
of
concern,
as
are
residential
post­
application
exposures
(
including
incidental
oral
exposure
to
toddlers
and
oral
and
dermal
exposure
from
swimming
activities
in
treated
lake
water).
Aggregate
risks
(
food,
drinking
water,
and
residential
exposure)
are
also
below
the
Agency's
level
of
concern.

There
is
a
potential
for
exposure
to
workers
through
handling
and
applying
imazapyr
as
well
as
exposure
to
post­
application
residues.
For
workers,
short­
and
intermediate­
term
risks
from
mixing,
loading,
and
applying
imazapyr
do
not
exceed
the
Agency's
level
of
concern
at
either
baseline
clothing,
or
with
the
addition
of
gloves.
There
are
no
dermal
post­
application
risks
to
workers,
and
inhalation
post­
application
risks
are
considered
negligible;
however,
the
Agency
has
determined
that
imazapyr
is
a
Toxicity
Category
I
primary
eye
irritant.
The
restricted
entry
interval
(
REI)
on
current
imazapyr
labels
is
12
hours.
Under
the
Worker
Protection
Standard
(
WPS;
40
CFR
Part
170),
a
48­
hour
REI
is
required
for
Category
I
eye
irritants.
The
WPS
also
requires
that
coveralls,
shoes
and
socks,
chemical
resistant
gloves,
and
protective
eyewear
be
used
for
early
entry.

There
are
no
risks
of
concern
to
terrestrial
birds,
mammals,
and
bees,
or
to
aquatic
invertebrates
and
fish.
However,
there
are
ecological
risks
of
concern
associated
with
the
use
of
imazapyr
for
non­
target
terrestrial
plants
and
aquatic
vascular
plants,
and
potential
risks
to
federally
listed
threatened
and
endangered
species
("
listed
species")
which
include
aquatic
vascular
plants,
terrestrial
and
semi­
aquatic
monocots
and
dicots
that
cannot
be
precluded
at
this
time.
Imazapyr
use
at
the
labeled
rates
on
non­
crop
areas
when
applied
as
a
spray
or
as
a
granular
to
forestry
areas
present
risks
to
non­
target
plants
located
adjacent
to
treated
areas.
Imazapyr
use
at
the
labeled
rates
on
Clearfield
 
corn,
which
is
resistant
to
imidazolinone
herbicides,
also
present
risks
of
concern
to
non­
target
plants
located
adjacent
to
treated
areas.
2
Because
imazapyr
is
an
herbicide
and
may
therefore
harm
non­
target
plants
exposed
via
drift,
the
Agency
is
requiring
strict
use
restrictions
to
be
placed
on
the
labels
for
all
imazapyr
products
to
help
minimize
spray
drift.
The
Agency
has
determined
that
the
specific
drift
language
amendments
specified
in
this
RED
will
substantially
reduce,
though
may
not
completely
eliminate,
the
risks
of
imazapyr
use
to
non­
target
plants.

I.
Introduction
The
Federal
Insecticide,
Fungicide,
and
Rodenticide
Act
(
FIFRA)
was
amended
in
1988
to
accelerate
the
reregistration
of
products
with
active
ingredients
registered
prior
to
November
1,
1984,
and
amended
again
by
the
Food
Quality
Protection
Act
of
1996
(
FQPA)
and
the
Pesticide
Registration
Improvement
Act
of
2003
(
PRIA)
to
set
time
frames
for
the
issuance
of
Reregistration
Eligibility
Decisions.
FIFRA
calls
for
the
development
and
submission
of
data
to
support
the
reregistration
of
an
active
ingredient,
as
well
as
a
review
of
all
data
submitted
to
the
U.
S.
Environmental
Protection
Agency.
Reregistration
involves
a
thorough
review
of
the
scientific
database
underlying
a
pesticide's
registration.
The
purpose
of
the
Agency's
review
is
to
reassess
the
potential
hazards
arising
from
the
currently
registered
uses
of
a
pesticide,
to
determine
the
need
for
additional
data
on
health
and
environmental
effects,
and
to
determine
whether
or
not
the
pesticide
meets
the
"
no
unreasonable
adverse
effects"
criteria
of
FIFRA.

On
August
3,
1996,
the
Food
Quality
Protection
Act
of
1996
(
FQPA)
was
signed
into
law.
This
Act
amended
FIFRA
and
the
Federal
Food
Drug
and
Cosmetic
Act
(
FFDCA)
to
require
reassessment
of
all
existing
tolerances
for
pesticides
in
food.
FQPA
also
requires
the
Agency
to
review
all
tolerances
in
effect
on
August
2,
1996,
by
August
3,
2006.
When
the
Agency
reassessed
the
imazapyr
tolerances
in
2003,
the
Agency
considered,
among
other
things,
aggregate
risks
from
non­
occupational
sources
of
pesticide
exposure,
whether
there
is
increased
susceptibility
among
infants
and
children,
and
the
cumulative
effects
of
pesticides
that
have
a
common
mechanism
of
toxicity.
When
the
Agency
determines
that
aggregate
risks
are
not
of
concern
and
concludes
that
there
is
a
reasonable
certainty
of
no
harm
from
aggregate
exposure,
the
tolerances
are
considered
reassessed.
The
Agency
decided
that,
for
those
chemicals
that
have
tolerances
and
are
undergoing
reregistration,
tolerance
reassessment
will
be
accomplished
through
the
reregistration
process.

As
mentioned
above,
FQPA
requires
the
Agency
to
consider
available
information
concerning
the
cumulative
effects
of
a
particular
pesticide's
residues
and
"
other
substances
that
have
a
common
mechanism
of
toxicity"
when
considering
whether
to
establish,
modify,
or
revoke
a
tolerance.
Unlike
other
pesticides
for
which
the
Agency
has
followed
a
cumulative
risk
approach
based
on
a
common
mechanism
of
toxicity,
the
Agency
has
not
made
a
common
mechanism
of
toxicity
finding
for
imazapyr
with
any
other
substances.
Therefore,
for
the
purposes
of
tolerance
reassessment,
which
was
completed
in
2003,
the
Agency
did
not
assume
that
imazapyr
shared
a
common
mechanism
of
toxicity
with
any
other
compound.
In
the
future,
if
additional
information
suggests
imazapyr
shares
a
common
mechanism
of
toxicity
with
other
compounds,
additional
testing
may
be
required
and
a
cumulative
assessment
may
be
necessary.
For
information
regarding
the
Agency's
efforts
to
determine
which
chemicals
have
a
3
common
mechanism
of
toxicity
and
to
evaluate
the
cumulative
effects
of
such
chemicals,
see
the
policy
statements
released
by
the
Agency's
Office
of
Pesticide
Programs
concerning
common
mechanism
determinations
and
procedures
for
cumulating
effects
from
substances
found
to
have
a
common
mechanism
on
EPA's
website
at
http://
EPA.
gov/
pesticides/
cumulative/.

This
document
presents
a
summary
of
the
Agency's
revised
human
health
and
ecological
risk
assessments,
its
progress
toward
tolerance
reassessment,
and
the
reregistration
eligibility
decision
for
imazapyr.
The
document
consists
of
six
sections.
Section
I
contains
the
regulatory
framework
for
reregistration
and
tolerance
reassessment.
Section
II
provides
a
profile
of
the
use
and
usage
of
the
chemical.
Section
III
gives
an
overview
of
the
revised
human
health
and
ecological
risk
assessments
based
on
data,
public
comments,
and
other
information
received
in
response
to
the
preliminary
risk
assessments.
Section
IV
presents
the
Agency's
reregistration
eligibility
and
risk
management
decisions.
Section
V
summarizes
label
changes
necessary
to
implement
the
risk
mitigation
measures
outlined
in
Section
IV.
Section
VI
provides
information
on
how
to
access
related
documents
and
contains
the
appendices
that
list
related
information
and
supporting
documents.
The
preliminary
and
revised
risk
assessments
for
imazapyr
are
available
in
the
Public
Docket,
under
docket
number
OPP­
2005­
0495
and
on
EPA's
web
page,
http://
www.
regulations.
gov.

II.
Chemical
Overview
Imazapyr
is
part
of
the
imidazolinone
chemical
class.
Imazapyr
is
a
systemic,
non­
selective,
pre­
and
post­
emergent
herbicide
used
for
the
control
of
a
broad
range
of
terrestrial
and
aquatic
weeds,
and
controls
plant
growth
by
preventing
the
synthesis
of
branched­
chain
amino
acids.
Imazapyr
is
applied
either
as
an
acid
or
as
the
isopropylamine
salt.

A.
Chemical
Background
Imazapyr
technical
was
first
registered
in
1985;
however,
a
non­
crop
end
use
product
had
been
previously
registered
in
July
1984.
The
first
food
use
on
corn
was
registered
in
April
1997.
In
2003,
the
aquatic
and
grassland
uses
were
registered
which
resulted
in
the
establishment
of
additional
tolerances.
Currently
there
are
24
tolerances
listed
in
40
CFR
§
180.500
for
residues
of
the
herbicide
imazapyr,
applied
as
the
acid
or
isopropylamine
salt,
which
were
reassessed
in
2003.
4
B.
Imazapyr
Acid
and
Salt
Nomenclature:
Imazapyr,
acid
Structure
N
HN
N
O
O
OH
Molecular
Formula
C13H15N3O3
IUPAC
Name
[
2­(
4­
isopropyl­
4­
methyl­
5­
oxo­
2­
imidazolin­
2­
yl)­
nicotinic
acid]
CAS
Number
81334­
34­
1
PC
Code
128821
Imazapyr,
salt
Molecular
Formula
C13H15N3O3C3H9N
IUPAC
Name
2­
Propanamine,
2­(
4,5­
dihydro­
4­
methyl­
4­(
1­
methylethyl)­
5­
oxo­
1H­
imidazol­
2­
yl]­
3­
pyridinecarboxylate
CAS
Number
81334­
34­
1
PC
Code
128821
C.
Use
Sites:

°
Imazapyr
is
used
for
pre­
and
post­
emergence
control
of
a
broad
range
of
weeds,
including
terrestrial
annual
and
perennial
grasses,
broad­
leaved
herbs,
woody
species,
and
riparian
and
emergent
aquatic
species.

°
Agricultural
uses
of
imazapyr
include
field
corn
and
grass.
Tolerances
are
established
for
imazapyr
residues
in
field
corn
and
its
forage
and
stover,
and
in
grass
forage
and
hay.
Tolerances
are
also
established
for
secondary
residues
of
imazapyr
in
milk,
meat,
fish,
and
shellfish.

°
Imazapyr
is
also
registered
for
use
on
a
variety
of
commercial
and
residential
use
sites,
including
forestry
sites,
rights­
of­
way,
fence
rows,
hedge
rows,
drainage
systems,
outdoor
industrial
areas,
outdoor
buildings
and
structures,
domestic
dwellings,
paved
areas,
driveways,
patios,
parking
areas,
walkways,
various
water
bodies
(
including
ponds,
lakes,
streams,
swamps,
wetlands,
stagnant
water,
and
urban
areas).

°
Imazapyr
may
also
be
used
as
a
spot
treatment
in
recreation
areas,
athletic
fields,
and
golf
course
roughs.

D.
Formulations:

°
Imazapyr
is
formulated
as
a
liquid,
a
wettable
powder
(
in
water
soluble
bags
only),
and
a
granular.
5
E.
Methods
of
Application:

°
Aquatic
applications
of
imazapyr
can
be
made
as
a
liquid.
Application
methods
include
aerial
and
application
to
water
via
boat.
Aqueous
imazapyr
formulations
may
be
mixed
with
surfactants
or
oils
for
application.
Applications
to
smaller
areas
may
be
made
with
handheld
equipment,
including
backpack
sprayers,
sprinkling
cans,
and
handgun
sprayers.

°
Terrestrial
applications
of
imazapyr
consist
of
ground
and
aerial
spray,
as
well
as
granular
broadcast
applications.
Granular
formulations
may
also
be
mixed
with
fertilizers,
surfactants
or
oils
for
application.
Applications
to
smaller
areas
may
be
made
with
handheld
equipment,
including
lowpressure
handwand
sprayers,
high­
pressure/
volume
handwand
sprayers,
push­
type
granular
spreaders,
backpack
granular
spreaders,
sprinkling
cans,
and
handgun
sprayers.
Aqueous
imazapyr
formulations
may
be
mixed
with
surfactants
or
oils
for
application
as
well
as
mixed
with
other
herbicides
and
fertilizers.

F.
Use
rates:

°
Application
rates
of
imazapyr
range
from
0.014
pounds
acid
equivalent
per
acre
(
lbs
a.
e./
acre)
on
corn
to
1.5
lbs
a.
e./
acre
on
non­
crop
areas
and
aquatic
sites.

G.
Annual
usage:

°
For
terrestrial
agricultural
uses
of
imazapyr,
the
use
on
corn
is
approximately
20,000
lbs/
year,
and
the
use
on
pastures
and
rangeland
is
approximately
2,000
lbs/
year.
The
average
percent
crop
treated
is
less
than
one
percent
for
both
uses.

H.
Technical
Registrant:

°
BASF
Corporation.

III.
Summary
of
Risk
Assessment
The
following
is
a
summary
of
the
Agency's
revised
human
health
effects
and
ecological
risk
assessment
for
imazapyr,
as
presented
fully
in
the
documents,
Imazapyr:
HED
Chapter
of
the
Reregistration
Eligibility
Decision
Document,
dated
December
8,
2005,
and
Screening
Level
Ecological
Risk
Assessment
for
the
Reregistration
Eligibility
Decision
Document
for
Imazapyr,
dated
December
9,
2005.
The
purpose
of
this
summary
is
to
assist
the
reader
by
identifying
key
features
and
findings
of
these
risks
assessments,
and
to
help
the
reader
better
understand
the
conclusions
reached
in
the
assessments.
6
The
human
health
and
ecological
risk
assessment
documents
and
supporting
information
listed
in
Appendix
C
were
used
to
reach
the
regulatory
decisions
for
imazapyr.
While
the
risk
assessments
and
related
addenda
are
not
included
in
this
document,
they
are
available
in
the
Public
Docket,
under
docket
number
OPP­
2005­
0495
and
on
the
internet
at
http://
www.
regulations.
gov.
Hard
copies
of
these
documents
may
be
found
in
the
OPP
public
docket
under
this
same
docket
number.

A.
Human
Health
Risk
Assessment
The
Agency
has
conducted
a
human
health
assessment
for
imazapyr
for
the
purposes
of
making
a
reregistration
decision.
The
Agency
evaluated
toxicological
and
chemistry
studies
submitted
for
imazapyr
and
determined
that
the
data
are
adequate
to
support
a
reregistration
decision.
In
addition,
the
Agency
has
conducted
dietary,
drinking
water,
residential,
aggregate,
and
worker
assessments
to
determine
the
potential
risks
associated
with
the
use
of
imazapyr.
More
in­
depth
details
of
the
health
effects
of
imazapyr
are
provided
in
the
human
health
risk
assessment.

For
a
complete
discussion,
see
Section
6.0
of
Imazapyr:
HED
Chapter
of
the
Reregistration
Eligibility
Decision
Document,
dated
December
8,
2005.

1.
Hazard
Profile
The
toxicological
database
for
imazapyr
is
complete.
Imazapyr
has
low
acute
toxicity
via
the
oral
(
Toxicity
Category
IV)
and
dermal
(
Toxicity
Category
III)
routes
of
exposure.
Imazapyr
has
been
placed
in
acute
Toxicity
Category
II
for
the
inhalation
route
of
exposure.
It
is
not
irritating
to
the
skin,
and
is
negative
for
dermal
sensitization;
however,
imazapyr
results
in
irreversible
eye
damage
(
Toxicity
Category
I)
as
seen
in
Table
1.
Normally,
an
acute
hazard
value
is
chosen
from
acute
(
non­
lethal),
subchronic,
or
developmental
toxicity
studies
from
which
there
is
reasonable
evidence
that
a
single
exposure
can
lead
to
a
potential
effect.
The
available
data
suggest
that
a
single
exposure
to
imazapyr
does
not
result
in
an
effect
of
concern
for
risk
assessment
purposes.
7
Table
1.
Acute
Toxicity
Data
for
Imazapyr
Guideline
Number
Study
Type
MRID
Numbers
Toxicity
Category
870.1100
Acute
Oral
Toxicity
41551002
93048016
IV
870.1200
Acute
Dermal
Toxicity
41551003
93048017
III
870.1300
Acute
Inhalation
Toxicity
00132032
93048018
II
870.2400
Acute
Eye
Irritation
41551001
93048019
I
Tested
with
99.3%
technical
fine
powder
870.2500
Acute
Dermal
Irritation
41551004
93048020
IV
870.2600
Skin
Sensitization
00131607
93048021
Negative
Most
of
the
toxicity
studies
with
imazapyr
showed
no
effects
to
minimal
effects,
even
at
the
HDT
(
highest
dose
tested).
There
is
no
evidence
of
acute
or
chronic
neurotoxicity
resulting
from
exposure
to
imazapyr.
No
developmental
toxicity
was
observed
in
rabbits
or
rats
up
to
the
HDT;
however,
maternal
toxicity,
based
on
salivation,
was
observed
in
rats
at
the
mid­
dose
(
300
mg/
kg/
day).
Neither
the
rat
nor
the
rabbit
study
showed
an
increased
susceptibility
of
the
fetus
to
imazapyr
administered
prenatally
or
post­
natally.
In
addition,
a
2­
generation
reproduction
rat
study
did
not
show
increased
susceptibility
to
offspring
at
doses
up
to
the
HDT.
There
were
no
compoundrelated
effects
in
a
one­
year
dietary
toxicity
study
in
beagle
dogs
up
to
the
HDT.
Imazapyr
was
classified
by
the
Agency
in
October
1995
as
a
"
Group
E"
chemical,
with
no
evidence
of
carcinogenicity
in
at
least
2
adequate
studies
in
the
rat
and
mouse.
This
decision
was
reaffirmed
on
May
22,
2003
by
a
subcommittee
of
the
Cancer
Assessment
Review
Committee
(
CARC).
Imazapyr
is
negative
for
mutagenic
potential
and
a
quantitative
cancer
risk
assessment
is
not
required.

The
Agency
selected
NOAELs
and
endpoints
for
risk
assessment
purposes
in
February
2003.
A
1­
year
dog
feeding
study
with
a
NOAEL
of
250
mg/
kg/
day
was
selected
for
calculating
the
chronic
RfD
because
it
was
the
lowest
NOAEL
in
the
imazapyr
database.
Actually,
the
250
mg/
kg/
day
dose
in
the
dog
study
was
both
the
NOAEL
and
the
highest
dose
tested
for
that
study.
Because
there
were
no
adverse
effects
seen
in
the
dog
study
or
in
any
of
the
imazapyr
toxicity
studies,
EPA
relied
on
a
structural
analog,
the
pesticide
imazapic
(
Cadre
®
)
,
to
choose
an
endpoint.
Imazapic
causes
skeletal
muscle
effects
in
dogs
at
5000
ppm
(
137
mg/
kg/
day
in
males
and
180
mg/
kg/
day
in
females).
Despite
imazapyr's
structural
similarity
to
imazapic,
as
well
as
its
similarity
to
the
pesticides,
imazethapyr
and
imazamethabenz­
methyl
(
Assert
®
)
,
the
available
data
do
not
support
the
conclusion
that
these
pesticides
share
a
common
mechanism
of
toxicity
such
that
combined
exposure
to
them
would
result
in
cumulative
effects.
First,
as
noted,
the
toxicity
data
for
imazapyr
show
no
adverse
effects,
including
no
skeletal
muscle
effects.
Second,
the
toxic
endpoints
for
the
three
structurally
similar
pesticides
are
quite
varied:
imazapic
(
skeletal
muscle
effects);
imazethapyr
(
an
increased
incidence
of
clinical
signs
during
gestation,
ulcerations
in
the
mucosal
layer
of
the
stomach
and
gall
bladder,
increased
abortions,
maternal
deaths,
decrements
in
body
weight
gain)
and
8
imazamethabenz­
methyl
(
transient
decreased
body
weight,
mild
liver
effects,
slight
increase
in
a
common
kidney
lesion).
Accordingly,
for
the
purposes
of
this
RED,
EPA
has
not
assumed
that
imazapyr
has
a
common
mechanism
of
toxicity.

Non­
cancer
risk
estimates
are
expressed
as
a
margin
of
exposure
(
MOE)
that
is
a
ratio
of
the
dose
from
a
toxicological
study
selected
for
risk
assessment,
typically
a
NOAEL,
to
the
predicted
exposure.
Estimated
MOEs
are
compared
to
a
level
of
concern
that
reflects
the
dose
selected
for
risk
assessment
and
uncertainty
factors
(
UFs)
applied
to
that
dose.
The
standard
UF
is
100X
and
includes
a
10X
for
interspecies
extrapolation
(
to
account
for
differences
between
laboratory
animals
and
humans)
and
a
10X
for
intraspecies
variation
(
to
account
for
differences
between
humans).
Additional
uncertainty
or
safety
factors
may
also
be
applied.
In
the
case
of
imazapyr,
the
Agency's
level
of
concern
is
an
MOE
of
100
which
includes
a
factor
of
10X
for
interspecies
extrapolation
and
10X
for
intraspecies
variation.
The
Special
FQPA
Safety
Factor
has
been
reduced
to
1X
because
there
are
no
residual
exposure
uncertainties,
no
increased
sensitivity
to
infants
and
children,
and
the
toxicity
database
is
essentially
complete.
Table
2
shows
the
endpoints
selected
to
assess
risks
for
imazapyr.

Table
2.
Summary
of
Toxicological
Doses
and
Endpoints
for
Imazapyr
Used
in
the
Human
Health
Risk
Assessment
Exposure
Scenario
Dose
Used
in
Risk
Assessment,
UF
Special
FQPA
SF
and
Level
of
Concern
(
LOC)
for
Risk
Assessment
Study
and
Toxicological
Effects
and
MRID
No.

Acute
Dietary
(
Females
13­
50
years
of
age
and
General
population
including
infants
and
children)
An
acute
dietary
endpoint
was
not
selected
based
on
the
absence
of
an
appropriate
endpoint
attributable
to
a
single
dose.

Chronic
Dietary
(
All
populations)
NOAEL=
250
mg/
kg/
day
UF
=
100
Chronic
RfD
=
2.5
mg/
kg/
day
FQPA
SF
=
1x
cPAD
=
chronic
RfD
FQPA
SF
=
2.5
mg/
kg/
day
1­
Year
Dog
[
feeding]
Study
No
LOAEL
was
demonstrated
with
imazapyr
at
doses
up
to
250
mg/
kg/
day
(
HDT;
MRID
41039502).
[
HIARC
assumed
this
dose
as
an
endpoint
for
RA
for
imazapyr,
based
on
skeletal
muscle
effects
seen
in
dogs
with
structural
analog
imazapic.]

Short
and
Intermediate
Term
Incidental
Oral
(
1­
30
days
and
1­
6
months)
NOAEL=
250
mg/
kg/
day
Residential
LOC
for
MOE
=
100)
1­
Year
Dog
[
feeding]
Study
No
LOAEL
was
demonstrated
with
imazapyr
at
doses
up
to
250
mg/
kg/
day
(
HDT;
MRID
41039502).
[
HIARC
assumed
this
dose
as
an
endpoint
for
RA
for
imazapyr,
based
on
skeletal
muscle
effects
seen
in
dogs
with
structural
analog
imazapic.]
9
Short
and
Intermediate
and
Long­
Term
Dermal
(
1
to
30
days,
1
to
6
months,
>
6
months)
Oral
study
NOAEL=
250
mg/
kg/
day
(
dermal
absorption
rate
=
100
%)
Occupational
LOC
for
MOE
=
100
(
Residential
LOC
for
MOE
=
100)
1­
Year
Dog
[
feeding]
Study
No
LOAEL
was
demonstrated
with
imazapyr
at
doses
up
to
250
mg/
kg/
day
(
HDT;
MRID
41039502).
[
HIARC
assumed
this
dose
as
an
endpoint
for
RA
for
imazapyr,
based
on
skeletal
muscle
effects
seen
in
dogs
with
structural
analog
imazapic.]

Short­
and
Intermediate
and
Long­
Term
Inhalation
(
1
to
30
days,
1
to
6
months,
>
6
months
)
Oral
study
NOAEL=
250
mg/
kg/
day
(
inhalation
absorption
rate
=
100%)
Occupational
LOC
for
MOE
=
100
(
Residential
LOC
for
MOE
=
100)
1­
Year
Dog
[
feeding]
Study
No
LOAEL
was
demonstrated
with
imazapyr
at
doses
up
to
250
mg/
kg/
day
(
HDT;
MRID
41039502).
[
HIARC
assumed
this
dose
as
an
endpoint
for
RA
for
imazapyr,
based
on
skeletal
muscle
effects
seen
in
dogs
with
structural
analog
imazapic.]

Cancer
Classified
as
Group
E.
No
evidence
of
carcinogenicity;
risk
assessment
not
required.
UF
=
uncertainty
factor,
FQPA
SF
=
Special
FQPA
safety
factor,
NOAEL
=
no
observed
adverse
effect
level,
LOAEL
=
lowest
observed
adverse
effect
level,
PAD
=
population
adjusted
dose
(
a
=
acute,
c
=
chronic),
RfD
=
reference
dose,
MOE
=
margin
of
exposure,
LOC
=
level
of
concern.

2.
Dietary
Risk
(
Food)

Dietary
risk
assessment
incorporates
both
exposure
to
and
toxicity
of
a
given
pesticide.
Dietary
risk
is
expressed
as
a
percentage
of
a
level
of
concern.
The
level
of
concern
is
the
dose
predicted
to
result
in
no
unreasonable
adverse
health
effects
to
any
human
population
subgroup,
including
sensitive
members
of
such
population
subgroups.
This
level
of
concern
is
referred
to
as
the
population­
adjusted
dose
(
PAD),
which
reflects
the
reference
dose
(
RfD),
acute
or
chronic,
adjusted
to
account
for
the
FQPA
safety
factor.

Estimated
risks
that
are
less
than
100%
of
the
PAD
are
below
EPA's
level
of
concern.
The
acute
PAD
(
aPAD)
is
the
highest
predicted
dose
to
which
a
person
could
be
exposed
on
any
given
day
with
no
adverse
health
effects
expected.
The
chronic
PAD
(
cPAD)
is
the
highest
predicted
dose
to
which
a
person
could
be
exposed
over
the
course
of
a
lifetime
with
no
adverse
health
effects
expected.
For
imazapyr,
a
chronic
RfD
of
0.25
mg/
kg/
day
is
used
in
estimating
the
dietary
risk.
The
RfD
includes
a
10x
for
interspecies
extrapolation
and
a
10x
for
intraspecies
variation.
Because
the
Special
FQPA
Safety
Factor
has
been
reduced
to
1X,
the
PAD
is
equivalent
to
the
RfD.
The
imazapyr
dietary
risk
assessment
uses
was
performed
using
the
Dietary
Exposure
Evaluation
Model
(
DEEMTM).

For
a
complete
discussion,
see
Section
6.0
of
Imazapyr:
HED
Chapter
of
the
Reregistration
Eligibility
Decision
Document,
dated
December
8,
2005.
10
a.
Acute
Dietary
Risk
(
Food))

As
noted
above,
an
acute
dietary
exposure
assessment
was
not
necessary
because
no
toxic
effects
resulting
from
acute
exposures
were
seen
in
the
imazapyr
acute
toxicity
database.
The
Agency
does
not
expect
acute
risks
resulting
from
dietary
exposure.

b.
Chronic
Dietary
Risk
(
Food)

For
the
chronic
dietary
exposure
assessment,
an
estimate
of
the
residue
level
in
each
food
or
food­
form
on
the
food
commodity
residue
list
is
multiplied
by
the
average
daily
consumption
estimate
for
that
food/
food­
form.
The
resulting
residue
consumption
estimate
is
summed
with
the
residue
consumption
estimates
for
all
other
food/
food
forms
on
the
commodity
residue
list
to
arrive
at
the
total
average
estimated
exposure.
Exposure
is
expressed
in
mg/
kg
body
weight/
day
and
risk
is
expressed
as
a
percent
of
the
chronic
PAD
(
cPAD).

Food
items
may
be
exposed
to
residues
of
imazapyr
in
three
ways:
via
direct
application,
via
irrigation
water
previously
treated
with
imazapyr,
or
via
livestock
ingestion
of
treated
commodities
resulting
in
secondary
residues.
To
assess
risks
resulting
from
residues
on
food,
a
screening
level
assessment
was
performed
using
the
Dietary
Exposure
Evaluation
Model
(
DEEMTM).

The
results
of
the
DEEMTM
analysis
show
that
all
population
subgroups'
dietary
exposure
to
imazapyr
residues
in
food
comprises
less
than
0.1%
of
the
cPAD.
These
results
are
based
on
tolerance
level
residues,
100%
crop
treated,
and
default
processing
factors,
all
of
which
are
considered
to
be
conservative
estimates
of
potential
chronic
dietary
risk.
Table
3
shows
exposure
levels
for
the
general
population
and
children
one
to
two
years
old,
the
most
highly
exposed
population
subgroup.

For
a
complete
discussion
of
the
health
effects
to
imazapyr,
please
see
Imazapyr:
Chronic
Dietary
Exposure
Assessment
for
the
Reregistration
Eligibility
Decision,
dated
March
26,
2003.

Table
3.
Summary
of
Food
Chronic
Dietary
Exposure
and
Risk
from
Imazapyr
Population
Subgroup
Dietary
Exposure
mg/
kg/
day
%
cPAD
General
U.
S.
Population
0.000340
<
0.1
Children
1­
2
years
old
0.000828
<
0.1
3.
Cancer
Dietary
Risk
(
Food)

A
cancer
dietary
exposure
assessment
is
not
required
because
imazapyr
is
classified
as
a
Group
E
chemical,
"
not
likely
to
be
carcinogenic."
11
4.
Drinking
Water
Dietary
Exposure
Drinking
water
exposure
to
pesticides
can
occur
through
groundwater
and
surface
water
contamination.
The
Agency
considers
both
acute
(
one
day)
and
chronic
(
lifetime)
drinking
water
risks
and
uses
either
modeling
or
actual
monitoring
data,
if
available,
to
estimate
those
risks.
For
imazapyr,
non­
cancer
chronic
concentration
in
drinking
water
was
estimated.
A
cancer
concentration
in
drinking
water
was
not
estimated
because
imazapyr
is
considered
"
not
likely
to
be
carcinogenic
in
humans."

To
estimate
drinking
water
concentrations
resulting
from
the
use
of
imazapyr,
screening
level
models
were
used.
Non­
crop
uses
with
high
and
low
application
rates,
and
corn
uses
were
modeled
to
represent
the
labeled
imazapyr
uses
(
1.5,
0.9,
and
0.014
lbs.
a.
i./
acre,
respectively).
The
highest
labeled
rate
for
imazapyr
is
1.5
lbs.
a.
i./
acre.

The
Agency
has
determined
that
the
residue
of
concern
for
imazapyr
in
drinking
water
is
parent
only.
Environmental
fate
data
suggest
that
imazapyr
is
mobile
and
persistent.
Except
for
photolysis
in
water,
imazapyr
was
stable
under
the
conditions
and
duration
of
the
submitted
fate
studies.
In
the
photolysis
study,
imazapyr
degraded
with
half­
lives
of
approximately
3
to
5
days.

To
predict
concentrations
of
imazapyr
that
may
be
present
in
surface
water
as
a
result
of
the
terrestrial
uses,
Tier
I
FQPA
Index
Reservoir
Screening
Tool
(
FIRST)
exposure
modeling
was
performed.
The
modeled
estimates
of
drinking
water
concentrations
(
EDWCs)
of
imazapyr
in
surface
water
for
chronic
durations
range
from
0.34
to
79
µ
g/
L.
These
values
were
established
by
modeling
imazapyr
use
on
corn
and
non­
crop
uses
with
high
and
low
application
rates.

To
predict
concentrations
of
imazapyr
in
ground
water
as
a
result
of
terrestrial
uses,
Tier
I
Screening
Concentration
in
Ground
Water
(
SCI­
GROW)
exposure
modeling
was
performed.
The
modeled
concentrations
of
imazapyr
in
ground
water
are
not
expected
to
exceed
36
µ
g/
L.
This
value
was
established
by
modeling
imazapyr
non­
crop
uses
at
the
highest
maximum
application
(
1.5
lbs
a.
i./
A).

Exposure
to
imazapyr
from
drinking
water
resulting
from
aquatic
applications
is
also
possible.
The
EDWC's
for
both
surface
and
ground
water
from
direct
application
to
surface
water
are
both
61
µ
g/
L.
This
does
not
take
into
account
the
current
imazapyr
label
requirement
of
a
one­
half
mile
setback
from
drinking
water
intakes
because
the
Agency
does
not
currently
have
an
approved
methodology
for
calculating
EDWCs
in
water
bodies
where
pesticides
are
applied
with
a
setback
distance
from
drinking
water
intakes.
As
a
result,
the
EDWC
is
more
conservative
than
had
setback
distances
been
considered.
Direct
applications
to
water
were
modeled
assuming
uniform
application
over
an
entire
reservoir
at
the
maximum
labeled
rate.

For
a
complete
discussion,
see
Section
6.2
of
the
Imazapyr:
HED
Chapter
of
the
Reregistration
Eligibility
Decision
Document,
dated
December
8,
2005.
12
5.
Chronic
Risk
from
Food
and
Drinking
Water
To
assess
chronic
risk
from
food
plus
drinking
water,
exposure
estimates
from
chronic
dietary
(
food)
and
chronic
drinking
water
assessments
were
combined
in
the
DEEMTM
modeling
program.
The
modeled
EDWC
of
imazapyr
in
surface
water
of
79
µ
g/
L
was
used
in
the
chronic
dietary
(
food
plus
water)
assessment.
This
value
was
established
by
modeling
imazapyr
non­
crop
uses
at
the
highest
maximum
application.
The
combined
chronic
exposure
for
the
general
U.
S.
population
and
all
population
subgroups
is
<
0.1%
of
the
cPAD.
The
most
highly
exposed
population
subgroup
is
infants
<
1
year
old
(
Table
4).
These
values
are
below
the
Agency's
level
of
concern.

Table
4.
Summary
of
Food
and
Water
Dietary
Exposure
and
Risk
Population
Subgroup
Dietary
Exposure
mg/
kg/
day
%
cPAD
(
Food
+
Water)
General
U.
S.
Population
0.002005
0.1
All
Infants
<
1
year
old
0.005732
0.1
6.
Residential
Risk
Residential
exposure
to
a
pesticide
can
occur
while
mixing,
loading,
or
applying
(
handling)
a
pesticide,
or
after
entering
areas
where
the
pesticide
had
previously
been
applied.
Residential
non­
cancer
risk
estimates
are
expressed
as
a
margin
of
exposure
(
MOE),
which
is
a
ratio
of
the
dose
from
a
toxicological
study
selected
for
risk
assessment,
typically
a
NOAEL,
to
the
predicted
exposure.
Estimated
MOEs
are
compared
to
a
level
of
concern
that
reflects
the
dose
selected
for
risk
assessment
and
UFs
applied
to
that
dose.
The
standard
UF
is
100X
and
includes
a
10X
for
interspecies
extrapolation
(
to
account
for
differences
between
laboratory
animals
and
humans)
and
a
10X
for
intraspecies
variation
(
to
account
for
differences
between
humans).
Additional
uncertainty
or
safety
factors
may
also
be
applied.
In
the
case
of
imazapyr,
the
Agency's
level
of
concern
for
inhalation,
dermal,
and
incidental
oral
is
an
MOE
of
100
that
includes
a
factor
of
10X
for
interspecies
extrapolation
and
10X
for
intraspecies
variation.
The
Special
FQPA
Safety
Factor
has
been
reduced
to
1X
because
there
are
no
residual
exposure
uncertainties,
no
increased
sensitivity
to
infants
and
children,
and
the
toxicity
database
is
essentially
complete.

Short­
term
exposures
were
assessed
for
residential
handlers
and
residential
postapplication
exposures
based
on
use
and
exposure
patterns
of
registered
imazapyr
products.
Based
on
the
current
use
pattern
for
imazapyr
and
the
fact
that
endpoints
are
the
same
across
all
durations
of
exposure,
the
Agency
does
not
expect
that
intermediate
or
long­
term
residential
exposures
will
be
higher
than
those
for
short­
term
exposures.
Inhalation,
dermal,
and
incidental
ingestion
were
considered
to
be
the
routes
of
exposure
for
persons
exposed
to
imazapyr.
The
maximum
labeled
rates
were
used
for
the
noncancer
residential
handler
and
non­
cancer
residential
post­
application
risk
assessments.

For
a
complete
discussion,
see
Section
6.3
of
the
Imazapyr:
HED
Chapter
of
the
Reregistration
Eligibility
Decision
Document,
dated
December
8,
2005.
13
a.
Residential
Handler
Summary
Residential
handler
assessments
are
based
on
the
assumptions
that
individuals
complete
all
tasks
associated
with
the
use
of
imazapyr
(
mixing,
loading,
and
application),
up
to
1,000
square
feet
are
treated,
and
individuals
are
wearing
shorts,
short­
sleeved
shirts,
socks,
and
shoes.
The
residential
handler
exposure
scenarios
consider
dermal
and
inhalation
exposure
to
adult
pesticide
handlers.
The
two
residential
handler
scenarios
were
assessed:
1)
mixing/
loading/
applying
emulsifiable
concentrates
with
low­
pressure
handwand,
and
2)
mixing/
loading/
applying
emulsifiable
concentrates
with
hose­
end
sprayer.
The
risks
for
these
scenarios
are
below
the
Agency's
level
of
concern
with
MOEs
well
above
the
target
MOE
of
100,
at
25,000
and
85,000,
respectively.

b.
Residential
Post­
application
Summary
Residential
post­
application
exposure
scenarios
are
also
considered
to
be
short­
term
and
consider
exposures
to
individuals
that
occur
as
a
result
of
an
area
previously
treated
with
imazapyr.
The
residential
post­
application
assessment
considers
dermal
exposure
to
children
and
adults,
as
well
as
incidental
oral
ingestion
exposures
to
toddlers.
A
series
of
assumptions
and
exposure
factors
served
as
the
basis
for
completing
the
residential
postapplication
risk
assessments.
The
assumptions
and
factors
used
in
the
risk
calculations
are
consistent
with
current
Agency
policy
for
completing
residential
exposure
assessments
(
i.
e.,
Standard
Operating
Procedures
for
Residential
Exposure
Assessment).
The
scenarios
included
in
the
residential
post­
application
exposure
assessment
were:
(
1)
adult
dermal
exposure/
residential
turf
(
high
contact
activities);
(
2)
toddler
dermal
exposure/
residential
turf
(
high
contact
activities);
(
3)
toddler
oral
exposure/
hand­
to­
mouth
activity
on
turf;
(
4)
toddler
oral
exposure/
object­
to­
mouth
activity
on
turf;
(
5)
toddler
oral
exposure/
incidental
soil
ingestion;
and
(
6)
toddler
oral
exposure/
incidental
ingestion
of
granules.
Post­
application
residential
risks
to
adults
and
toddlers
are
below
the
Agency's
level
of
concern
for
all
scenarios
assessed
with
MOEs
of
720
and
430,
respectively,
on
the
day
of
application.

c.
Combined
Post­
application
Residential
Summary
Additionally,
combined
residential
risks
resulting
from
the
combining
of
separate
post­
application
exposure
scenarios,
when
it
is
likely
they
can
occur
simultaneously,
do
not
exceed
the
Agency's
level
of
concern
with
MOEs
greater
than
100
on
the
day
of
application.
These
combined
post­
application
exposure
scenarios
for
toddlers
are:
dermal,
hand­
to­
mouth,
object­
to­
mouth,
and
incidental
soil
ingestion.
The
combined
non­
dietary
MOE
for
toddlers
using
the
turf
spray
scenario
is
410.
14
d.
Recreational
Uses
Imazapyr
may
be
applied
by
broadcast
application
to
aquatic
freshwater
sites
to
control
floating
or
emergent
aquatic
vegetation.
Adults
and
children
may
be
exposed
when
swimming
in
treated
water
bodies
following
application
of
imazapyr.
The
potential
for
postapplication
incidental
ingestion
and
dermal
exposure
to
adults,
children,
and
toddlers
as
a
result
of
swimming
in
treated
waters
immediately
following
application
has
also
been
assessed.
Post­
application
risks
to
adults,
children,
and
toddlers
swimming
in
treated
waters
following
application
of
imazapyr
are
below
the
Agency's
level
of
concern
with
MOEs
ranging
from
68,000
to
1,000,000.

7.
Aggregate
Risk
Aggregate
risk
combines
exposure
from
food,
drinking
water,
and,
if
applicable,
residential
exposure.
For
imazapyr,
the
following
aggregate
risk
assessments
were
conducted:
short­
term
aggregate
(
food
+
drinking
water
+
short­
term
residential)
and
long­
term
aggregate
risk
assessment
(
food
+
drinking
water
only).
Based
on
the
current
use
patterns
of
imazapyr,
the
Agency
does
not
expect
exposure
durations
that
would
result
in
intermediate­
or
long­
term
residential
exposures;
therefore
long­
term
aggregate
risk
assessment
consists
of
exposure
from
food
and
drinking
water
only.
A
cancer
aggregate
risk
assessment
is
not
required
because
imazapyr
is
classified
as
a
Group
E
chemical,
"
not
likely
to
be
carcinogenic".

For
adult
short­
term
aggregate
exposure,
the
Agency
aggregated
chronic
food
and
drinking
water
exposures
with
residential
handler
and
post­
application
exposures.
The
adult
residential
exposure
scenarios
resulting
from
application
and
post­
application
activities
on
turf
were
used.
For
short­
term
aggregate
exposure
to
children,
the
Agency
aggregated
chronic
food
and
drinking
water
exposures
for
toddlers
(
1­
2
years
of
age)
and
combined
these
with
post­
application
dermal
and
incidental
oral
exposures
(
combined
hand­
to­
mouth,
object­
to­
mouth,
and
soil
ingestion)
from
activity
on
turf.
The
estimated
MOEs
are
above
100,
with
values
of
410
for
children
and
720
for
adults.
Therefore,
short­
term
aggregate
risks
are
below
the
Agency's
level
of
concern.

Because
the
Agency
does
not
expect
chronic
residential
exposure,
long­
term
aggregate
risks
are
equal
to
chronic
dietary
risks
(
food
plus
water).
As
described
above
in
Section
5,
these
risks
are
below
the
Agency's
level
of
concern.

For
a
complete
discussion,
see
Section
7.0
of
the
Imazapyr:
HED
Chapter
of
the
Reregistration
Eligibility
Decision
Document,
dated
December
8,
2005.

8.
Occupational
Risk
Workers
can
be
exposed
to
a
pesticide
while
mixing,
loading,
or
applying
a
pesticide,
and
when
entering
a
treated
site.
Non­
cancer
worker
risk
estimates
are
expressed
as
a
margin
of
exposure
(
MOE)
that
is
a
ratio
of
the
dose
from
a
toxicological
study
selected
for
risk
assessment,
typically
a
NOAEL,
to
the
predicted
exposure.
Estimated
MOEs
are
compared
to
a
level
of
concern
that
reflects
the
dose
selected
for
risk
assessment
and
uncertainty
factors
(
UFs)
applied
to
that
dose.
The
standard
UF
is
15
100X
and
includes
a
10X
for
interspecies
extrapolation
(
to
account
for
differences
between
laboratory
animals
and
humans)
and
a
10X
for
intraspecies
variation
(
to
account
for
differences
between
humans).
Additional
uncertainty
or
safety
factors
may
also
be
applied.
In
the
case
of
imazapyr,
the
NOAEL
is
250
mg/
kg/
day
taken
from
the
1­
year
dog
feeding
study
and
an
MOE
of
100
is
considered
protective
for
worker
risks.

The
Agency
initially
calculates
the
handler
risks
using
the
least
protective
measures.
This
is
called
the
baseline
assessment,
and
assumes
normal
work
clothing
and
no
personal
protective
equipment
(
PPE).
If
there
is
a
risk
concern
at
this
level,
the
Agency
considers
the
use
of
protective
measures
(
e.
g.,
personal
protective
equipment
and
engineering
controls)
to
lower
the
risk.
PPE
can
include
an
additional
layer
of
clothing,
chemical­
resistant
gloves,
and
a
respirator.
Common
examples
of
engineering
controls
include:
enclosed
tractor
cabs,
closed
loading
systems,
and
water­
soluble
packaging.

For
a
complete
discussion,
see
the
Occupational
and
Residential
Exposure
Assessment
and
Recommendations
for
the
Reregistration
Eligibility
Decision
Document
for
Imazapyr,
dated
August
31,
2005.

a.
Occupational
Handler
Summary
The
Agency
has
determined
that
workers
may
be
exposed
to
imazapyr
while
mixing,
loading,
and
applying,
as
well
as
flagging
for
aerial
applications.
In
the
absence
of
chemical­
specific
monitoring
data
for
imazapyr,
exposure
analyses
were
performed
using
surrogate
data
from
the
Pesticide
Handlers
Exposure
Database
(
PHED)
and
the
Outdoor
Residential
Exposure
Task
Force
(
ORETF).
For
information
on
the
scenarios
that
use
ORETF
data,
please
see
the
Occupational
and
Residential
Exposure
Assessment
and
Recommendations
for
the
Reregistration
Eligibility
Decision
Document
for
Imazapyr,
dated
August
31,
2005.
The
MOEs
for
occupational
exposures
were
calculated
for
short­
term
and
intermediate­
term
exposures
because
these
durations
of
exposures
are
likely
based
on
current
labels.
Long­
term
handler
exposures
are
not
expected
to
occur
for
imazapyr.

For
all
scenarios,
short­
and
intermediate­
term
risks
do
not
exceed
the
Agency's
level
of
concern
(
i.
e.,
the
MOEs
are
greater
than
100)
at
either
baseline
PPE
(
longsleeved
shirt,
long
pants,
no
gloves,
and
no
respirator),
or
with
the
addition
of
gloves.
MOEs
ranged
from
10
to
1,100,000.
Scenarios
that
require
the
addition
of
chemical
resistant
gloves
include
mixing
and
loading
liquid
formulations
for
aerial
applications
to
aquatic
sites,
terrestrial
non­
crop
sites,
forestry
sites,
and
areas
grazed
or
cut
for
hay.
The
addition
of
chemical
resistant
gloves
are
also
required
for
workers
that
are
mixing,
loading,
and
applying
liquid
and
granular
formulations
via
handwands,
backpack
spreaders
and
sprayers,
and
handgun
sprayers
for
non­
crop
and
aquatic
uses.
MOEs
for
these
scenarios
with
the
addition
of
chemical
resistant
gloves
ranged
from
460
to
22,000.

b.
Post­
application
Occupational
Summary
The
Agency
has
determined
that
individuals
may
be
exposed
to
imazapyr
by
working
in
areas
that
have
previously
been
treated.
Both
short­
term
and
intermediateterm
occupational
postapplication
dermal
exposure
may
occur.
Inhalation
exposures
are
16
expected
to
be
negligible
in
outdoor
postapplication
scenarios
because
imazapyr
has
a
low
vapor
pressure
and
due
to
the
dilution
with
ambient
air
expected
after
outdoor
application.
As
such,
inhalation
postapplication
exposures
are
not
considered
in
this
assessment.

All
risks
calculated
for
short­
term
and
intermediate­
term
dermal
postapplication
exposure
to
workers
resulting
from
scouting,
hand
weeding,
irrigation,
detasseling,
and
hand­
harvesting
are
below
the
Agency's
level
of
concern
(
MOEs
range
from
4,100
to
700,000)
on
day
zero
approximately
12
hours
following
application.
Although
the
MOEs
are
greater
than
100
for
post­
application
workers,
the
restricted­
entry
level
(
REI)
must
be
set
at
48­
hour
REI
because
imazapyr
has
high
acute
toxicity
(
Category
I
for
eye
irritation).

9.
Incident
Reports
Approximately
20
incidents
involving
human
exposure
to
imazapyr
have
been
reported.
However,
none
were
listed
under
the
"
definite,"
"
probable,"
or
"
possible"
certainty
categories.
In
general,
medical
care
was
less
frequently
used
in
all
cases
compared
to
other
pesticide­
related
incidents,
and
not
a
single
case
required
hospitalization
or
treatment
in
a
critical
care
unit.
The
most
common
symptom
reported
was
eye
irritation,
which
was
four
times
more
prevalent
than
any
other
symptom.
Additional
health
effects
included:
dermal
irritation,
throat
irritation,
nausea,
and
coughing
or
choking.

For
a
complete
discussion,
see
the
Review
of
Imazapyr
Incident
Reports,
dated
February
23,
2006.

B.
Ecological
Risk
Assessment
The
Agency
has
conducted
an
environmental
assessment
for
imazapyr
for
the
purposes
of
making
a
reregistration
decision.
The
Agency
evaluated
environmental
fate
and
ecological
studies
submitted
for
imazapyr
and
determined
that
the
data
are
adequate
to
support
a
reregistration
decision.
More
in­
depth
details
of
the
environmental
fate
and
persistence
of
imazapyr
are
provided
in
the
environmental
risk
assessment.

For
a
complete
discussion,
see
the
Screening
Level
Ecological
Risk
Assessment
for
the
Reregistration
Eligibility
Decision
Document
for
Imazapyr,
dated
December
9,
2005.
17
1.
Environmental
Fate
and
Transport
The
herbicide
imazapyr
is
an
anionic,
organic
acid
that
is
non­
volatile
and
is
both
persistent
and
mobile
in
soil.
Commercial
formulations
contain
either
imazapyr
acid
or
the
imazapyr
isopropylamine
salt,
both
of
which
are
dissolved
in
a
water
solution.
Imazapyr
is
mainly
in
anionic
form
at
typical
environmental
pH
levels,
and
the
behavior
of
the
acid
and
salt
forms
are
expected
to
be
similar.
Laboratory
studies
show
imazapyr
is
essentially
stable
to
hydrolysis,
aerobic
and
anaerobic
soil
degradation,
as
well
as
aerobic
and
anaerobic
aquatic
metabolism.
Field
dissipation
study
observations
are
consistent
with
imazapyr's
intrinsic
ability
to
persist
in
soils
and
move
via
runoff
to
surface
water
and
to
leach
to
groundwater.

Upon
direct
application,
or
indirect
release
into
surface
water,
photolysis
is
the
only
identified
mechanism
for
imazapyr
degradation
in
the
environment.
The
half­
life
of
imazapyr
is
approximately
3
to
5
days
in
surface
water.
The
major
identified
metabolites
were
pyridine
hydroxy­
dicarboxylic
acid,
pyridine
dicarboxylic
acid,
and
nicotinic
acid.
Under
laboratory
aerobic
aquatic
conditions,
the
aerobic
aquatic
metabolism
half­
lives
for
hydroxy­
dicarboxylic
acid
and
pyridine
dicarboxylic
acid
were
in
the
range
of
3
to
8
days
in
two
different
sediment/
water
systems.
Metabolites
hydroxy­
dicarboxylic
acid
and
pyridine
dicarboxylic
acid
are
expected
to
be
more
polar,
thus
more
rapidly
excreted
than
imazapyr,
and
no
more
toxic
than
the
parent
compound.
Additionally,
pyridine
hydroxy­
dicarboxylic
acid
is
considered
to
be
less
stable
than
the
parent
compound.
Nicotinic
acid
is
a
possible
neurotoxin
at
high
dose
levels,
but
there
is
no
concern
for
low
exposures.
Nicotinic
acid
(
also
called
Niacin
and
referred
to
as
Vitamin
B3)
is
considered
an
essential
nutrient.
Imazapyr
is
not
expected
to
bioaccumulate
in
aquatic
organisms
because
it
exists
as
an
anion
at
typical
environmental
pHs.

2.
Ecological
Risk
Assessment
To
estimate
potential
ecological
risk,
the
Agency
integrates
the
results
of
exposure
and
ecotoxicity
studies
using
the
risk
quotient
method.
Risk
quotients
(
RQs)
are
a
screening
level
measure
for
potential
risk
and
are
calculated
by
dividing
exposure
estimates
by
ecotoxicity
values,
both
acute
and
chronic,
for
various
wildlife
species.
RQs
are
then
compared
to
levels
of
concern
(
LOCs).

Table
5
lists
the
LOCs
used
in
the
risk
assessment.
Generally,
the
higher
the
RQ,
the
greater
the
potential
risk.
Risk
characterization
provides
further
information
on
the
likelihood
of
adverse
effects
occurring
by
considering
the
fate
of
the
chemical
in
the
environment,
communities
and
species
potentially
at
risk,
their
spatial
and
temporal
distributions,
and
the
nature
of
the
effects
observed
in
studies.
18
Table
5.
Levels
of
Concern
for
Ecological
Risk
If
RQ
>
LOC
value
given
below 
Then
EPA
presumes 
Terrestrial
Organisms
Aquatic
Organisms
Plants
Risk
Presumption
0.5
0.5
1
Acute
Risk­
there
is
potential
for
acute
risk;
regulatory
action
may
be
warranted
0.1
0.05
1
Acute
Endangered
Species­
regulatory
action
may
be
warranted;
further
analysis
is
needed
1
1
N/
A
Chronic
Risk­
there
is
potential
for
chronic
risk;
regulatory
action
may
be
warranted
The
Agency
has
determined
that
there
are
no
risks
of
concern
to
terrestrial
birds,
mammals,
and
bees,
or
to
aquatic
invertebrates
and
fish.
For
terrestrial
organisms,
available
acute
and
chronic
toxicity
data
indicate
that
imazapyr
acid
and
salt
are
practically
non­
toxic
to
birds,
mammals,
and
honeybees.
Acute
risks
to
both
mammals
and
birds
were
not
calculated
because
LC50/
LD50
(
Median
Lethal
Concentration/
Median
Lethal
Dose)
values
were
greater
than
highest
concentration
tested.
Chronic
LOC's
were
also
not
exceeded
for
these
organisms.
In
addition,
imazapyr
shows
low
toxicity
to
bees.
Therefore,
there
is
minimal
risk
to
birds,
mammals,
and
honeybees.

For
aquatic
organisms,
available
acute
and
chronic
toxicity
data
indicate
that
imazapyr
acid
and
salt
are
practically
non­
toxic
to
fish,
invertebrates,
and
non­
vascular
aquatic
plants.
Acute
risks
to
fish
and
aquatic
invertebrates
were
not
calculated
because
LC50
values
were
greater
than
the
highest
concentration
tested.
Chronic
LOC's
were
also
not
exceeded
for
these
organisms.
In
addition,
no
LOC's
were
exceeded
for
aquatic
nonvascular
plants.
Therefore,
there
is
minimal
risk
to
fish,
aquatic
invertebrates,
and
aquatic
non­
vascular
plants.
However,
there
is
an
uncertainty
for
estuarine/
marine
fish
and
invertebrates,
since
no
toxicity
data
were
available
to
observe
the
prolonged
effects
of
imazapyr
to
estuarine/
marine
fish
and
invertebrates.
These
organisms
were
assumed
to
have
similar
sensitivity
as
freshwater
fish
and
invertebrates.

The
Agency
has
determined
that
there
are
ecological
risks
of
concern
associated
with
the
use
of
imazapyr
for
non­
target
terrestrial
plants
and
aquatic
vascular
plants,
and
potential
risks
to
endangered
species
(
aquatic
vascular
plants,
terrestrial
and
semi­
aquatic
monocots
and
dicots).
Because
the
ecological
risks
of
concern
for
imazapyr
are
only
to
non­
target
plants,
the
remainder
of
this
Ecological
Risk
Assessment
section
of
the
RED
document
will
address
risks
to
non­
target
plants.
19
a.
Plant
Toxicity
Terrestrial
plant
toxicity
studies
with
monocots
and
dicots
indicate
that
seedling
emergence
and
vegetative
vigor
are
severely
impacted
by
exposure
to
imazapyr
acid
and
to
the
isopropylamine
salt
of
imazapyr.
Seedling
emergence,
based
on
"
fresh
weight",
was
adversely
impacted
in
monocots
(
wheat)
at
an
EC25
(
Effect
Concentration)
of
0.0046
lb
a.
e./
acre
and
in
dicots
(
sugar
beet)
with
an
EC25
of
0.0024
lb
a.
e./
acre
(
Table
6).
Vegetative
vigor
in
monocots,
based
on
"
fresh
weight",
was
adversely
impacted
by
both
imazapyr
acid
and
the
isopropylamine
salt
of
imazapyr
at
an
EC25
of
0.012
lb
a.
e./
acre
in
wheat.
In
vegetative
vigor
studies
with
dicots
(
cucumber),
imazapyr
acid
was
more
toxic
than
the
isopropylamine
salt
of
imazapyr
with
an
EC25
of
0.0009
lbs
a.
e./
acre.
Non­
lethal
effects
included
stunting,
chlorosis,
and
necrosis.

Table
6.
Summary
of
Selected
Endpoints
for
Imazapyr
Terrestrial
Toxicity
Studies
Endpoint
(
lbs
a.
e./
acre)
Plant
Species
Effect
EC
25
EC
05/
NOAEC
MRID
Terrestrial
Monocots
Emergence
0.0046
0.00099
40811801
Wheat
Vegetative
Vigor
0.012
0.0039
43889101
Terrestrial
Dicots
Sugar
Beet
Emergence
0.0024
0.00017
40811801
Cucumber
Vegetative
Vigor
0.0009
0.000064
40811801
For
aquatic
plants,
available
toxicity
studies
indicate
that
imazapyr
acid
and
the
isopropylamine
salt
are
highly
toxic
and
expected
to
exert
detrimental
effects
to
aquatic
vascular
plants.
The
EC50
for
the
aquatic
vascular
plant
(
duckweed)
is
0.018
mg
a.
e./
L
(
NOAEC
0.011
mg
a.
e./
L),
based
on
inhibition
of
plant
growth
and
reduction
of
frond
count
(
Table
7).

Table
7.
Summary
of
Selected
Endpoints
for
Imazapyr
Aquatic
Toxicity
Studies
Endpoint
(
mg
a.
e./
L)
Plant
Species
Effect
EC
50
NOAEC
MRID
Aquatic
Vascular
Inhibition
of
plant
growth
0.018
0.011
43889102
Aquatic
Nonvascular
Inhibition
of
plant
growth
11.5
7.6
43889102
b.
Terrestrial
Plant
Risk
Table
8
presents
the
RQs
for
terrestrial
plants
for
three
imazapyr
uses
and
both
ground
and
aerial
spray
applications.
For
the
terrestrial
non­
crop
use
of
imazapyr
and
the
application
rates
of
0.9
and
1.5
lbs
a.
e./
acre,
RQ
LOCs
exceeded
for
all
non­
endangered
and
endangered
monocots
and
dicots
located
adjacent
to
treated
areas,
in
semi­
aquatic
areas,
and
as
a
result
of
runoff
and
spray
drift
with
the
exception
of
non­
endangered
monocots
receiving
spray
drift
alone
from
ground
applications
at
0.9
lb
a.
e./
acre.
RQs
were
higher
for
aerial
applications
when
compared
to
ground
applications,
as
expected
given
the
assumption
that
5%
of
aerial
sprays
and
1%
of
ground
sprays
drift
to
non­
target
areas.
20
For
Clearfield
 
corn
and
the
label
application
rate
of
0.014
lbs
a.
e./
acre,
LOCs
were
exceeded
for
non­
endangered
monocots
and
dicots
located
in
semi­
aquatic
areas
(
based
on
"
channelized
runoff"
ratio)
when
exposed
to
imazapyr
via
ground
or
aerial
spray
application.
LOCs
were
not
exceeded
for
non­
endangered
monocots
and
dicots
inhabiting
dry
areas
(
based
on
"
sheet
runoff"
ratio)
via
ground
or
aerial
application,
or
from
spray
drift
alone.
With
the
exception
of
monocots
receiving
drift
alone,
the
endangered
species
LOCs
were
exceeded
for
terrestrial
plants
located
adjacent
to
treated
areas,
in
semi­
aquatic
areas
and
as
a
result
of
spray
drift
alone
from
aerial
application
on
cornfields.
For
ground
application,
the
endangered
species
LOCs
were
exceeded
for
both
monocots
and
dicots
located
in
semi­
aquatic
areas.
However,
the
endangered
species
LOCs
were
not
exceeded
for
monocots
inhabiting
dry
areas
or
exposed
to
spray
drift
alone.
Exposure
to
dicots
from
spray
drift
alone
exceeds
the
endangered
species
LOC
but
is
not
expected
to
exceed
the
non­
endangered
species
LOC.

Table
8.
Terrestrial
Plant
Risk
Quotient
Summary
for
Terrestrial
Spray
Uses
Non­
endangered
RQs
Endangered
RQs
Scenario
Adjacent
to
treated
sites
Semiaquatic
areas
Drift
Adjacent
to
treated
sites
Semiaquatic
areas
Drift
Terrestrial
non­
crop
high
application
rate
(
1.5
lbs
a.
e./
acre
Ground
spray
application
Monocot
20**
166**
1.3**
91*
773*
3.9*

Dicot
38**
319**
17**
529*
4500*
234*

Aerial
spray
application
Monocot
26**
114**
6.3**
121*
530*
19*

Dicot
50**
219**
83**
706*
3090*
1170*

Terrestrial
non­
crop
low
application
rate
(
0.9
lbs
a.
e./
acre)
Ground
spray
application
Monocot
12**
100**
0.75
55*
464*
2.3*

Dicot
23**
191**
10**
318*
2700*
141*

Aerial
spray
application
Monocot
16**
68**
3.8**
73*
318*
124*

Dicot
30**
131**
50**
424*
1850*
703*

Clearfield
 
Corn
(
0.014
lbs
a.
e./
acre)
Ground
spray
application
Monocot
0.18
1.6**
0.01
0.85
7.2*
0.04
Dicot
0.35
3.0**
0.16
4.9*
42*
2.2*

Aerial
spray
application
Monocot
0.24
1.1**
0.06
1.1*
5.0*
0.18
Dicot
0.47
2.0**
0.78
6.6*
29*
11*

*
indicates
an
exceedance
of
the
Endangered
Species
LOC
(
LOC=
1).
**
indicates
an
exceedance
of
the
Acute
Risk
LOC
(
LOC=
1).
21
For
the
aquatic
non­
crop
use
of
imazapyr
at
the
maximum
application
rate
of
1.5
lbs
a.
e./
acre,
LOCs
were
exceeded
for
non­
endangered
and
endangered
monocots
and
dicots
located
adjacent
to
or
on
the
edge
of
lakes
and
ponds
as
a
result
of
flooding
semiaquatic
areas
and
spray
drift
from
a
direct
application
to
surface
water
(
Table
9).
RQs
were
higher
for
plants
adjacent
to
or
on
the
edge
of
lakes
and
ponds
versus
those
exposed
via
drift.

Table
9.
Terrestrial
Plant
Risk
Quotient
Summary
for
Aquatic
Spray
Uses
Non­
endangered
RQs
Endangered
RQs
Scenario
Water
overflows
to
flood
a
terrestrial
site
Incoming
tide
pushes
water
to
flood
a
terrestrial
site
Water
overflows
to
flood
a
terrestrial
site
Incoming
tide
pushes
water
to
flood
a
terrestrial
site
Aquatic
non­
crop
high
application
rate
(
1.5
lbs
a.
e./
acre)
Ground
spray
application
Monocot
163**
24*
758**
111*

Dicot
313**
46*
4412**
647*

*
indicates
an
exceedance
of
the
Endangered
Species
LOC
(
LOC=
1).
**
indicates
an
exceedance
of
the
plant
LOC
(
LOC=
1).

For
the
granular
uses
of
imazapyr
at
the
maximum
application
rates
of
1.5
lbs
a.
e./
acre
and
0.5
lbs
a.
e./
acre,
LOCs
were
exceeded
for
both
non­
endangered
and
endangered
monocots
and
dicots
located
adjacent
to
treated
areas,
in
semi­
aquatic
areas
and
as
a
result
of
runoff
from
application
on
non­
crop
areas
(
Table
10).
Currently,
EFED
does
not
perform
chronic
risk
assessments
for
terrestrial
plants.

Table
10.
Terrestrial
Plant
Risk
Quotient
Summary
for
Granular
Uses
Non­
endangered
RQs
Endangered
RQs
Scenario
Adjacent
to
treated
sites
Semi­
aquatic
areas
Adjacent
to
treated
sites
Semi­
aquatic
areas
Terrestrial
non­
crop
high
application
rate
(
1.5
lbs
a.
e./
acre)

Monocot
16**
163**
76*
758*

Dicot
31**
313**
441*
4410*

Terrestrial
non­
crop
low
application
rate
(
0.5
lbs
a.
e./
acre)

Monocot
5.4**
54**
25*
253*

Dicot
10**
104**
147*
1471*

*
indicates
an
exceedance
of
the
Endangered
Species
LOC
(
LOC=
1).
**
indicates
an
exceedance
of
the
Acute
Risk
LOC
(
LOC=
1).

For
a
complete
discussion,
see
the
Screening
Level
Ecological
Risk
Assessment
for
the
Reregistration
Eligibility
Decision
Document
for
Imazapyr,
dated
December
9,
2005.
22
c.
Aquatic
Plant
Risk
For
imazapyr,
there
are
exceedances
of
the
endangered
and
non­
endangered
LOCs
for
vascular
plants
for
runoff/
drift
from
ground
and
aerial
spray
and
granular
applications
at
high
and
low
rates
for
terrestrial
use
sites
(
Table
11).
However,
there
were
no
exceedances
of
non­
vascular
aquatic
plant
LOCs
for
these
scenarios.
There
were
no
exceedances
of
aquatic
plants
LOCs
for
the
Clearfield
 
corn
application
scenario.

Table
11.
Aquatic
Plant
Risk
Quotient
Summary
for
Terrestrial
Uses
Non­
endangered
RQs
Endangered
RQs
Scenario
Non­
Vascular
Vascular
Vascular
Non­
Crop
(
high
application
rate,
1.5
lbs
a.
e./
acre)

Ground
Application
<
0.01
4.5**
7.4*

Aerial
Application
<
0.01
4.7**
7.6*

Non­
Crop
(
low
application
rate,
0.9
lbs
a.
e./
acre)

Ground
Application
<
0.01
2.5**
4.1*

Aerial
Application
<
0.01
2.8**
4.6*

Forestry
Granular
(
high
application
rate,
1.5
lbs
a.
e./
acre
Broadcast
<
0.01
4.3**
7.0*

Forestry
Granular
(
low
application
rate,
0.5
lbs
a.
e./
acre
Broadcast
<
0.01
1.4**
2.3*

Clearfield
 
Corn
(
0.014
lbs
a.
e./
acre)

Ground
Application
<
0.01
0.04
0.07
Aerial
Application
<
0.01
0.04
0.07
*
indicates
an
exceedance
of
Endangered
Species
LOC
(
LOC=
1).
**
indicates
an
exceedance
of
plant
LOC
(
LOC=
1).

The
imazapyr
direct
application
to
water
scenario
for
aquatic
uses
indicated
exceedance
of
the
non­
endangered
LOCs
for
vascular
plants
inhabiting
various
water
depths
(
Table
12).
Likewise,
endangered
vascular
plant
LOCs
were
exceeded
for
the
direct
application
to
waters
at
all
three
depths
considered.
There
were
no
LOC
exceedances
for
non­
vascular
aquatic
plants.

Table
12.
Aquatic
Plant
Risk
Quotient
Summary
for
Aquatic
Use
Non­
endangered
Endangered
Scenario
Water
Depth
Non­
Vascular
Vascular
Vascular
1
foot
0.048
31**
50*

3
feet
0.016
10**
17*
Direct
Application
to
Water
(
1.5
lbs
a.
e./
acre)
2
meters
<
0.01
4.7**
7.6*

*
indicates
an
exceedance
of
Endangered
Species
LOC
(
LOC=
1).
**
indicates
an
exceedance
of
Acute
Risk
LOC
(
LOC=
1).

For
a
complete
discussion,
see
the
Screening
Level
Ecological
Risk
Assessment
for
the
Reregistration
Eligibility
Decision
Document
for
Imazapyr,
dated
December
9,
2005.
23
3.
Incident
Reports
The
Environmental
Incident
Information
System
(
EIIS)
database
has
records
of
12
incidents
related
to
the
use
of
imazapyr
(
April
2005).
Incidents
reported
include
impacts
to
terrestrial
and
aquatic
plants
and
possibly
birds
and
fish.
There
are
several
reports
of
spray
drift
affecting
plants
on
adjacent
property
and
one
report
of
agricultural
runoff
to
a
pond
resulting
in
a
possible
fish
kill
from
imazapyr.
In
this
report,
it
could
not
be
definitively
determined
that
the
fish
kill
was
due
to
exposure
to
imazapyr.
Another
report
concerning
mortality
in
birds
and
fish
was
based
on
an
incident
using
a
mixture
of
herbicides,
one
of
which
was
imazapyr.
Because
a
mixture
was
used,
it
could
not
be
definitively
determined
that
the
mortalities
were
due
to
exposure
to
imazapyr.
One
incident
was
a
mixed
herbicidal
spray,
including
imazapyr,
that
resulted
in
a
bird,
terrestrial
and
aquatic
plant,
and
fish
kill.
Another
incident
involved
a
goldfish
kill
from
suspected
runoff
following
aerial
application
of
imazapyr.
However,
the
cause
of
the
kill
could
not
be
determined.
Nine
other
incidents
involving
plants
have
also
been
reported.

4.
Endangered
Species
Risk.

As
discussed
previously,
imazapyr
acid
and
the
imazapyr
isopropylamine
salt
are
used
in
both
aquatic
and
terrestrial
environments.
The
screening
level
risk
assessment
for
endangered
species
indicates
that
imazapyr
RQs
exceed
the
endangered
species
LOCs
for
the
specified
use
scenario
in
the
following
taxonomic
groups:

°
non­
target
aquatic
vascular
plants
for
non­
crop
uses
(
both
high
and
low
application
rates)
and
for
direct
application
to
water
(
RQs
are
listed
in
Tables
11
and
12).

°
non­
target
terrestrial
plants
­
monocots
and
dicots
adjacent
to
treated
areas,
semi­
aquatic
areas,
and
subject
to
drift
for
non­
crop
uses
at
both
high
and
low
application
rates
by
ground
and
aerial
spray
and
granular
applications;
monocots
and
dicots
adjacent
to
semi­
aquatic
areas
for
Clearfield
 
corn
use
by
ground
spray
application;
dicots
adjacent
to
treated
sites
for
Clearfield
 
corn
use
by
ground
spray
application;
and
monocots
and
dicots
adjacent
to
treated
areas
and
semi­
aquatic
areas
for
Clearfield
 
corn
use
by
aerial
spray
application;
and
for
dicots,
drift
from
Clearfield
 
corn
use
by
ground
and
aerial
spray
application
(
RQs
are
listed
in
Tables
8,
9,
and
10).

Registered
uses
of
imazapyr
acid
and
the
imazapyr
isopropylamine
salt
will
have
no
direct
effect
on
endangered
or
threatened
fish,
aquatic
invertebrates,
non­
vascular
aquatic
plants
(
algae),
birds
or
mammals.
However,
there
is
a
potential
concern
for
indirect
effects
to
listed
species
with
either
broad
or
narrow
dependencies
on
impacted
plant
species/
populations/
communities
for
habitat,
feeding
or
cover
requirements.

Risks
to
endangered
species
identified
in
the
Environmental
Fate
and
Ecological
Risk
Assessment
for
Imazapyr
are
based
solely
on
the
Agency's
screening
level
assessment
and
do
not
constitute
"
may
effect"
findings
under
the
Endangered
Species
Act.
Rather,
this
assessment
serves
as
a
screen
to
determine
the
need
for
any
species
24
specific
assessments
that
will
evaluate
whether
exposure
may
be
at
levels
that
could
cause
harm
to
specific
listed
species
and
their
critical
habitat.
That
assessment
refines
the
screening­
level
assessment
to
take
into
account
the
geographic
area
of
pesticide
use
in
relation
to
the
listed
species,
the
habits
and
habitat
requirements
of
the
listed
species,
etc.
If
the
Agency's
specific
assessments
result
in
the
need
to
modify
use
of
the
pesticide
in
specific
geographic
areas,
those
changes
to
the
pesticide's
registration
will
take
effect
through
the
process
described
in
the
Agency's
Federal
Register
Notice
(
54
FR
27984)
regarding
implementation
of
the
Endangered
Species
Protection
Program.

For
a
complete
discussion,
see
the
Screening
Level
Ecological
Risk
Assessment
for
the
Reregistration
Eligibility
Decision
Document
for
Imazapyr,
dated
December
9,
2005.

IV.
Risk
Management,
Reregistration,
and
Tolerance
Reassessment
Decision
A.
Determination
of
Reregistration
Eligibility
Section
4(
g)(
2)(
A)
of
the
Federal
Insecticide,
Fungicide
and
Rodenticide
Act
(
FIFRA)
calls
for
the
Agency
to
determine,
after
submission
of
relevant
data
concerning
an
active
ingredient,
whether
pesticides
containing
the
active
ingredient
are
eligible
for
reregistration.
The
Agency
has
previously
identified
and
required
the
submission
of
the
generic
(
i.
e.,
active
ingredient
specific)
data
required
to
support
reregistration
of
products
containing
imazapyr.

The
Agency
has
completed
its
assessment
of
the
dietary,
residential,
occupational,
and
ecological
risks
associated
with
the
use
of
pesticides
containing
the
active
ingredient
imazapyr.
Based
on
a
review
of
these
data
and
public
comments
on
the
Agency's
assessments
for
the
active
ingredient
imazapyr,
the
Agency
has
sufficient
information
on
the
human
health
and
ecological
effects
of
imazapyr
to
make
decisions
as
part
of
the
reregistration
process
under
FIFRA,
as
amended
by
the
Food
Quality
Protection
Act
(
FQPA).
Note
that
the
Agency
reassessed
the
imazapyr
tolerances
in
2003.
The
Agency
has
determined
that
currently
registered
uses
of
imazapyr
will
not
pose
unreasonable
risks
or
adverse
effects
to
humans
or
the
environment
if
the
risk
mitigation
measures
and
label
changes
outlined
in
the
RED
are
implemented;
therefore,
products
containing
imazapyr
are
eligible
for
reregistration.
These
products
containing
imazapyr
are
eligible
for
reregistration
provided
that:
(
i)
required
product­
specific
data
are
submitted;
(
ii)
the
risk
mitigation
measures
outlined
in
the
document
are
adopted;
and,
(
iii)
label
amendments
are
made
to
reflect
these
measures.
Products
that
contain
active
ingredients
in
addition
to
imazapyr
will
be
reregistered
when
all
of
their
other
active
ingredients
also
are
reregistered.
Label
changes
are
described
in
Section
V
of
this
document.
Appendix
B
identifies
the
generic
data
that
the
Agency
reviewed
as
part
of
its
determination
of
reregistration
eligibility
of
imazapyr
and
lists
the
submitted
studies
that
the
Agency
found
acceptable.

The
Agency
has
determined
that
specific
drift
language
amendments
proposed
in
this
RED
will
substantially
reduce,
though
may
not
eliminate,
the
risks
to
non­
target
plants.
25
Based
on
its
evaluation
of
imazapyr,
the
Agency
has
determined
that
imazapyr
products,
unless
labeled
and
used
as
specified
in
this
document,
would
present
risks
inconsistent
with
FIFRA.
Accordingly,
should
a
registrant
fail
to
implement
any
of
the
risk
mitigation
measures
identified
in
this
document,
the
Agency
may
take
regulatory
action
to
address
the
risk
concerns
from
the
use
of
imazapyr.
If
all
changes
outlined
in
this
document
are
incorporated
into
the
product
labels,
then
all
current
risks
for
imazapyr
will
be
adequately
mitigated
for
the
purposes
of
this
determination
under
FIFRA.
Once
a
comprehensive
endangered
species
assessment
is
completed,
further
changes
to
these
registrations
may
be
necessary.

B.
Public
Comments
and
Responses
Through
the
Agency's
public
participation
process,
the
Agency
worked
with
stakeholders
and
the
public
to
reach
the
regulatory
decisions
for
imazapyr.
During
the
public
comment
period
on
the
risk
assessments,
which
closed
on
February
21,
2006,
the
Agency
received
comments
from
the
BASF
Corporation,
the
Nebraska
Department
of
Agriculture,
and
the
California
Indian
Basketweavers
Association
(
CIBA).
For
responses
to
public
comments
from
the
BASF
Corporation
and
the
Nebraska
Department
of
Agriculture
please
refer
to
the
EFED
Responses
to
Imazapyr
Phase
3
Comments,
dated
March
29,
2006
and
is
located
in
the
public
docket,
http://
www.
regulations.
gov,
OPP­
2005­
0495.
Response
to
comments
from
CIBA
is
as
follows:

As
stated
above,
the
CIBA
submitted
a
public
comment
dated
2/
21/
06
to
Docket
ID
Number
EPA­
OPP­
2005­
0495
in
response
to
the
Imazapyr:
HED
Chapter
of
the
Reregistration
Eligibility
Decision
Document,
dated
December
8,
2005.
This
group
is
concerned
about
long­
term
use
of
pesticides
such
as
imazapyr
in
forests
and
on
rangeland
and
their
possible
effects
on
wildlife,
native
plants,
life
cycles
and
contamination
of
basket­
making
materials,
water,
and
traditional
foods.
CIBA
stated,
"
Currently,
no
pesticide
residue
tolerance
has
been
established
for
traditional
foods
eaten
and
gathered
by
Native
Americans,
and
the
health
and
risk
assessment
is
not
protective
for
Native
American
uses
of
plants
growing
on
public
lands
where
high
volumes
of
imazapyr
and
other
herbicide
uses
occur.
CIBA
cited
a
study
conducted
by
C.
Ando,
et
al.
at
the
California
Department
of
Pesticide
Regulation
(
CDPR)
claiming
that,
following
forest
treatments,
the
researchers
found
that
residues
of
"
herbicides"
in
certain
forest
plants
used
by
Indians
greatly
exceed
tolerances
currently
established
for
the
same
chemicals
in
certain
fruits,
berries,
herbs,
and
grains."

Many
of
CIBA's
statements
seem
to
be
addressing
general
concerns
associated
with
various
pesticide
uses
on
rangeland
and
in
forests.
The
published
study
supporting
the
group's
claims
only
addressed
the
use
of
glyphosate,
hexazinone,
and
triclopyr
in
California
forests
and
residues
of
these
three
pesticides
in
four
native
species
used
by
local
Indians.
Maximum
residues
of
these
three
herbicides
in
the
four
sampled
native
plants
were
found
at
19­
241
ppm
on
the
day
of
treatment;
half­
lives
varied
from
1
week
to
19
weeks.
However,
none
of
the
tested
pesticides
are
chemically
similar
to
imazapyr.
There
are
several
details
about
imazapyr
that,
taken
together,
should
minimize
CIBA's
concerns
for
imazapyr
risks,
specifically:
Imazapyr
tolerances
at
40
CFR
180.500
have
been
established
at
100
ppm
in
grass
forage
and
30
ppm
in
grass
hay.
These
tolerances
26
reflect
spot
treatment
of
weed
species
in
pasture
and
rangeland
at
0.75
lb
a.
i./
A,
but
<
10%
of
any
given
acre
may
be
treated.
Therefore,
the
likelihood
of
imazapyr
use
on
plants
traditionally
used
by
Native
Americans,
unless
targeted
as
a
weed,
is
unlikely.
If
spot­
treated
as
a
weed,
the
plant
is
likely
to
be
exhibiting
symptoms
of
phytotoxicity.
Applications
in
forests
are
also
typically
directed,
spot
treatments
although
broadcast
treatments
may
be
applied
at
<
1.5
lb
a.
i./
A.
The
preharvest
interval
is
7
days.
The
Agency
has
usage
information
indicating
that
<
2.5%
of
all
U.
S.
pasture
and
rangeland
is
treated
with
imazapyr.

As
described
in
the
12/
8/
05
HED
Chapter
of
the
RED,
there
are
no
acute
risks
associated
with
imazapyr
because
a
single
dose
of
the
chemical
does
not
induce
adverse
effects.
Aggregate
chronic/
long­
term
risk
is
<
0.1%
of
the
chronic
Population
Adjusted
Dose
(
cPAD),
i.
e.,
a
negligible
risk.
Short­
term
aggregate
risks
(
MOEs
of
410
in
children
and
720
in
adults)
are
well
below
the
Agency's
level
of
concern
(
i.
e.,
the
MOEs
estimated
for
pesticide
exposures
are
greater
than
100).

In
other
words,
additional
human
exposures
to
imazapyr
in
excess
of
those
expected
from
consumption
of
default,
high
volume
foods
could
still
occur
in
subpopulations
before
the
Agency's
levels
of
concern
(
100%
of
the
cPAD
and
an
MOE
of
100
for
short­
term)
would
be
approached.
Note
that
greater
emphasis
is
being
placed
by
the
Agency
on
determining
consumption
and
exposure
patterns
of
U.
S.
subpopulations,
such
as
Native
Americans,
that
have
thus
far
not
been
sufficiently
represented
in
USDA's
Continuing
Survey
of
Food
Intakes
by
Individuals
(
CSFII),
1994­
1996
and
1998
to
permit
more
refined
dietary
exposure
assessments
to
be
conducted
for
these
groups.

C.
Regulatory
Position
1.
Food
Quality
Protection
Act
Findings
a.
"
Risk
Cup"
Determination
Imazapyr
tolerances
were
reassessed
in
2003
when
new
food
uses
were
established.
However,
part
of
reregistration
under
FIFRA,
the
Agency
assessed
the
risks
associated
with
imazapyr.
The
Agency
has
concluded
that
aggregate
exposure
to
imazapyr
through
food,
drinking
water,
and
residential
sources
is
within
its
own
"
risk
cup"
and
that
human
health
risks
from
these
combined
exposures
are
within
acceptable
levels.
The
Agency
has
determined
that
the
human
health
risks
from
these
combined
exposures
are
within
acceptable
levels.
In
other
words,
the
Agency
has
concluded
that
the
tolerances
for
imazapyr
meet
FQPA
safety
standards.
In
reaching
this
determination,
the
Agency
has
considered
the
available
information
on
the
special
sensitivity
of
infants
and
children,
as
well
as
aggregate
exposure
from
food,
drinking
water,
and
residential
uses.
The
FQPA
safety
factor
has
not
been
retained
for
imazapyr
because
acceptable
developmental
and
reproduction
studies
have
been
submitted
and
reviewed
and
there
is
low
concern
and
no
residual
uncertainties
for
pre­
and
post­
natal
toxicity.
In
addition,
the
dietary
and
residential
assessments
are
not
expected
to
underestimate
exposure.
27
b.
Endocrine
Disruptor
Effects
The
Agency
is
required
under
the
FFDCA,
as
amended
by
FQPA,
to
develop
a
screening
program
to
determine
whether
certain
substances
(
including
all
pesticide
active
and
other
ingredients)
"
may
have
an
effect
in
humans
that
is
similar
to
an
effect
produced
by
a
naturally
occurring
estrogen,
or
other
endocrine
effects
as
the
Administrator
may
designate."
Following
recommendations
of
its
Endocrine
Disruptor
Screening
and
Testing
Advisory
Committee
(
EDSTAC),
the
Agency
determined
that
there
was
a
scientific
basis
for
including,
as
part
of
the
program,
the
androgen
and
thyroid
hormone
systems,
in
addition
to
the
estrogen
hormone
system.
The
Agency
also
adopted
EDSTAC's
recommendation
to
include
evaluations
of
potential
effects
in
wildlife.
For
pesticides,
the
Agency
will
use
FIFRA
and,
to
the
extent
that
effects
in
wildlife
may
help
determine
whether
a
substance
may
have
an
effect
in
humans,
FFDCA
authority
to
require
the
wildlife
evaluations.
As
the
science
develops
and
resources
allow,
screening
for
additional
hormone
systems
may
be
added
to
the
Endocrine
Disruptor
Screening
Program
(
EDSP).

In
the
available
toxicity
studies
on
imazapyr,
there
was
no
evidence
of
endocrine
disruption.
When
the
appropriate
screening
and/
or
testing
protocols
being
considered
under
the
EDSP
have
been
developed,
imazapyr
may
be
subject
to
additional
screening
and/
or
testing
to
better
characterize
effects
related
to
endocrine
disruption.

c.
Cumulative
Risks
Risks
summarized
in
this
document
are
those
that
result
only
from
the
use
of
imazapyr.
Unlike
other
pesticides
for
which
the
Agency
has
followed
a
cumulative
risk
approach
based
on
a
common
mechanism
of
toxicity,
the
Agency
has
not
made
a
common
mechanism
of
toxicity
finding
for
imazapyr
and
any
other
substances.
Therefore,
for
the
purposes
of
reregistration,
the
Agency
has
not
assumed
that
imazapyr
shares
a
common
mechanism
of
toxicity
with
other
compounds.

2.
Tolerance
Summary
Imazapyr
tolerances
were
reassessed
in
2003
when
new
food
uses
were
established.
This
document
does
not
result
in
any
additional
tolerances
being
reassessed.
The
following
information
is
provided
for
informational
purposes
only.
A
tolerance
summary
is
presented
below
in
Table
13.
The
Agency
has
determined
that
the
residue
of
concern
for
tolerance
expression
in
plants,
livestock,
fish,
and
water
is
imazapyr
per
se.

Existing
tolerances
are
established
in
40
CFR
§
180.500
for
residues
of
the
herbicide
imazapyr,
[
2­[
4,5­
dihydro­
4­
methyl­
4­(
1­
methylethyl)­
5­
oxo­
1H­
imidazol­
2­
yl]­
3­
pyridinecarboxylic
acid],
applied
as
the
acid
or
ammonium
salt,
in/
on
corn,
grass,
milk,
meat,
poultry,
eggs,
fish,
and
shellfish.
Adequate
data
are
available
to
reassess
the
existing
tolerance
levels
for
imazapyr.

The
submitted
magnitude
of
the
residue
data
for
corn,
grass,
milk,
meat,
poultry,
and
eggs
are
fulfilled
and
are
adequate
for
the
purposes
of
reregistration;
however,
acceptable
supporting
storage
stability
data
on
corn
forage
and
fodder
and
clarification
of
28
the
identity
and
quantity
of
spray
additives
utilized
in
the
grass
field
trials
remain
outstanding.
The
submitted
processing
data
on
corn
are
acceptable,
and
the
results
of
these
studies
show
that
imazapyr
does
not
appreciably
concentrate
in
the
processed
commodities
of
field
corn.
The
submitted
confined
rotational
crop
data
are
adequate
for
the
purposes
of
reregistration,
and
limited
field
rotational
crop
data
and
rotational
crop
tolerances
are
not
required
at
this
time.

Imazapyr
is
registered
for
use
on
aquatic
areas
and
the
treated
water
from
these
sites
may
be
diverted
to
irrigate
food
or
feed
crops.
No
data
depicting
imazapyr
residue
levels
in
irrigated
crops
have
been
submitted
and
at
present,
no
label
restriction
prohibits
use
of
imazapyr
treated
waters
for
irrigated
crops.
Data
on
irrigated
crops
or
label
restrictions
that
prohibit
the
irrigation
of
crops
with
imazapyr
treated
water
for
120
days
following
application
and/
or
demonstrates
non­
detectable
residue
levels
of
imazapyr
in
irrigation
water
by
laboratory
analysis
prior
to
use
are
required
for
reregistration.

Two
methods
are
currently
listed
in
the
Pesticide
Analytical
Manual
(
PAM)
Vol.
II
for
enforcing
tolerances
of
imazapyr
in/
on
corn
commodities.
Method
M
2468
is
a
gas
chromatograph/
mass
spectrometry
(
GC/
MS)
method
with
a
limit
of
quantitation
(
LOQ)
of
 
0.01
ppm
for
imazapyr
in/
on
corn
grain,
forage
and
fodder,
and
Method
M
2657
is
a
capillary
electrophoresis
(
CE)
method
with
UV
detection
that
has
a
LOQ
of
0.05
ppm
for
imazapyr
in/
on
corn
grain,
forage
and
fodder.

A
series
of
CE/
UV
Methods
are
currently
listed
as
enforcement
methods
for
determining
imazapyr
in/
on
grass
forage
and
hay
(
Method
M
3023),
in
livestock
tissues
(
Method
M
3184),
in
milk
and
milk
fat
(
Methods
M
3075
and
M
3223),
and
in
fish
and
shellfish
tissues
(
Method
M
3066).
These
methods
are
similar
to
the
enforcement
method
M
2657,
and
each
of
these
methods
also
includes
directions
for
a
confirmatory
analysis
using
LC/
MS.

Each
of
the
above
methods
has
undergone
a
successful
independent
laboratory
validation
(
ILV)
trial.
Adequate
radiovalidation
data
were
also
submitted
for
CE/
UV
methods
M
3066,
M
3075,
and
M
3184,
demonstrating
the
efficiency
of
these
methods
in
extracting
residues
from
aged
samples.

The
Food
and
Drug
Administration
(
FDA)
multiresidue
methods
do
not
exhibit
sufficient
sensitivity
to
other
imidazolinone
herbicides,
and
thus
there
is
no
reasonable
expectation
that
these
methods
would
prove
to
be
useful
for
determining
residues
of
imazapyr.

Currently
there
are
no
Codex,
Canadian
or
Mexican
tolerances
for
residues
of
imazapyr
in/
on
corn,
grass,
fish,
shellfish,
or
livestock
commodities.
Thus,
international
harmonization
of
tolerances
is
not
an
issue
at
this
time.
29
a.
Tolerances
Currently
Listed
and
Tolerance
Reassessment
Table
13.
Tolerance
Table
Commodity
Current
Tolerance
(
ppm)
Reassessed
Tolerance
(
ppm)
Comments
(
Correct
commodity
definition)

Corn,
field,
forage
0.05
0.05
Corn,
field,
grain
0.05
0.05
Corn,
field,
stover
0.05
0.05
The
available
residue
data
support
the
reassessed
tolerances.

Grass,
forage
100
100.0
Grass,
hay
30
30.0
The
available
residue
data
support
the
reassessed
tolerances.

Fish
1.0
1.0
The
available
residue
data
support
the
reassessed
tolerances.

Shellfish
0.1
0.10
The
available
residue
data
support
the
reassessed
tolerances.

Fat
of
cattle
0.05
0.05
Kidney
of
cattle
0.20
0.20
Meat
byproducts,
excluding
kidney,
of
cattle
0.05
0.05
Meat
of
cattle
0.05
0.05
Fat
of
sheep
0.05
0.05
Kidney
of
sheep
0.20
0.20
Meat
byproducts,
excluding
kidney
of
sheep
0.05
0.05
Meat
of
sheep
0.05
0.05
Fat
of
goats
0.05
0.05
Kidney
of
goats
0.20
0.20
Meat
byproducts,
excluding
kidney,
of
goats
0.05
0.05
Meat
of
goats
0.05
0.05
Fat
of
horses
0.05
0.05
Kidney
of
horses
0.20
0.20
Meat
byproducts,
excluding
kidney,
of
horses
0.05
0.05
Meat,
of
horses
0.05
0.05
Milk
0.01
0.01
The
available
residue
data
support
the
reassessed
tolerances.
30
D.
Regulatory
Rationale
The
Agency
has
determined
that
imazapyr
is
eligible
for
reregistration
provided
the
risk
mitigation
measures
outlined
in
this
document
are
adopted,
and
label
amendments
are
made
to
reflect
these
measures.
This
decision
considers
the
risk
assessments
conducted
by
the
Agency
and
the
significance
of
the
use
of
imazapyr.

The
following
is
a
summary
of
the
rationale
for
managing
risks
associated
with
the
use
of
imazapyr.
Where
labeling
revisions
are
warranted,
specific
language
is
set
forth
in
the
summary
tables
in
Section
V
of
this
document.

1.
Human
Health
Risk
Management
In
the
human
health
risk
assessment,
dietary
risks
(
food
and
drinking
water),
residential
handler
dermal
and
inhalation
risks,
residential
oral
and
dermal
postapplication
risks,
and
aggregate
risks
do
not
exceed
the
Agency's
level
of
concern.
Therefore,
no
risk
mitigation
measures
are
required
to
address
these
exposure
scenarios.

a.
Occupational
Risk
Mitigation
As
discussed
in
Section
III.
A.
7.
a,
short­
and
intermediate­
term
dermal
and
inhalation
risks
to
occupational
handlers
who
may
be
exposed
to
imazapyr
during
mixer/
loader/
applicator
activities
are
below
the
Agency's
level
of
concern
at
either
the
baseline
level
of
personal
protective
equipment
or
with
the
addition
of
gloves.
To
protect
workers
mixing
and
loading
liquid
formulations
for
aerial
applications
to
aquatic
sites,
terrestrial
non­
crop
sites,
forestry
sites,
and
areas
grazed
or
cut
for
hay,
these
handlers
are
required
to
wear
chemical
resistant
gloves.
To
protect
workers
mixing,
loading,
and
applying
liquid
and
granular
formulations
via
handwands,
backpack
spreaders
and
sprayers,
and
handgun
sprayers
for
non­
crop
and
aquatic
uses,
those
handlers
are
required
to
wear
chemical­
resistant
gloves.
As
a
condition
of
reregistration,
imazapyr
formulation
into
wettable
powder
end
use
products
is
not
allowed
unless
they
are
packaged
in
water
soluble
bags.
Label
language
will
include
the
following
measures:

Liquids:
Chemical­
resistant
gloves
are
required
for
all
mixers
and
loaders
of
liquid
formulations
and
for
applicators
using
hand­
held
equipment.

Granulars:
Chemical­
resistant
gloves
are
required
for
all
mixers
and
loaders
of
granular
formulations
and
applicators
using
hand­
held
equipment.

Dry
Flowables
and
Wettable
Powders
(
water
soluble
bags):
Chemical­
resistant
gloves
are
required
for
all
mixers
and
loaders
of
dry
flowable
and
water
soluble
bag
formulations
and
applicators
using
hand­
held
equipment.
31
For
all
agricultural
postapplication
exposure
scenarios,
postapplication
occupational
risks
are
below
HED's
level
of
concern
(
i.
e.,
the
MOEs
are
greater
than
100)
on
day
0
 
approximately
12
hours
following
application.
However,
the
Agency
has
determined
that
imazapyr
is
a
Toxicity
Category
I
primary
eye
irritant
and
under
the
Worker
Protection
Standard
(
WPS;
40
CFR
Part
170),
a
48­
hour
REI
is
required.
Also
under
the
WPS,
early
entry
requires
that
coveralls,
shoes
and
socks,
chemical
resistant
gloves,
and
protective
eyewear
be
used.

2.
Environmental
Risk
Management
To
address
risks
to
non­
target
aquatic
and
terrestrial
plants,
additional
directions
for
use
and
use
restrictions
will
be
added
to
product
labels
to
reduce
potential
risks.
Specific
language
and
restrictions
are
discussed
below.

a.
Non­
target
Terrestrial
Plant
Risk
Mitigation
As
mentioned
earlier,
screening­
level
risk
quotients
(
RQs)
for
non­
target
terrestrial
plants
resulting
from
the
terrestrial
and
aquatic
spray
uses
range
from
0.01
to
319
for
non­
target
terrestrial
plants
and
from
0.04
to
4,500
for
endangered
terrestrial
plants.
Likewise,
RQs
for
non­
endangered
terrestrial
plants
from
the
granular
use
range
from
5.4
to
313
for
non­
target
terrestrial
plants
and
from
25
to
4,410
for
endangered
non­
target
terrestrial
plants.
For
aquatic
uses
of
imazapyr,
the
RQs
for
non­
endangered
terrestrial
plants
ranged
from
24
to
313
and
111
to
4,412
for
endangered
terrestrial
plants.
Direct
exposure
scenarios
were
not
calculated,
but
RQs
for
plants
and
endangered
plants
would
be
significantly
higher
than
those
estimated
from
exposure
via
spray
drift
and/
or
runoff.

Because
imazapyr
is
an
herbicide
and
may
therefore
harm
non­
target
plants
exposed
via
drift,
to
be
eligible
for
reregistration
labels
must
require
that
imazapyr
be
applied
in
a
manner
that
minimizes
spray
drift.
Strict
use
restrictions
to
minimize
spray
drift
will
be
placed
on
the
labels
for
all
imazapyr
products.
This
language
will
include:

For
aerial
applications,
applicators
are
required
to
use
a
Coarse
or
coarser
droplet
size
(
ASABE
S572)
or,
if
specifically
using
a
spinning
atomizer
nozzle,
applicators
are
required
to
use
a
volume
mean
diameter
(
VMD)
of
385
microns
or
greater
for
release
heights
below
10
feet;
Applicators
are
required
to
use
a
Very
Coarse
or
coarser
droplet
size
or,
if
specifically
using
a
spinning
atomizer
nozzle,
applicators
are
required
to
use
a
VMD
of
475
microns
or
greater
for
release
heights
above
10
feet;
applicators
must
consider
the
effects
of
nozzle
orientation
and
flight
speed
when
determining
droplet
size;

For
aerial
applications,
applicators
are
required
to
use
upwind
swath
displacement;

For
aerial
applications,
the
boom
length
must
not
exceed
60%
of
the
wingspan
or
90%
of
the
rotor
blade
diameter,
to
reduce
spray
drift;
32

For
aerial
applications,
applications
with
wind
speeds
less
than
3
mph
and
with
wind
speeds
greater
than
10
mph
are
prohibited;

For
groundboom
applications,
applicators
are
required
to
use
a
nozzle
height
below
4
feet
above
the
ground
or
plant
canopy
and
Coarse
or
coarser
droplet
size
(
ASABE
S572)
or,
if
specifically
using
a
spinning
atomizer
nozzle,
applicators
are
required
to
use
a
volume
mean
diameter
(
VMD)
of
385
microns
or
greater;

For
groundboom
applications,
applications
with
wind
speeds
greater
than
10
mph
are
prohibited;

Applications
into
temperature
inversions
are
prohibited.

The
Agency
has
determined
that
specific
drift
language
amendments
proposed
in
this
RED
will
substantially
reduce,
though
may
not
completely
eliminate,
the
risks
to
non­
target
plants.

b.
Non­
target
Aquatic
Plant
Risk
Mitigation
Screening­
level
risk
quotients
(
RQs)
for
both
the
aquatic
and
terrestrial
uses
of
imazapyr
were
calculated.
The
RQs
for
non­
endangered
aquatic
plants
from
the
aquatic
use
range
from
<
0.01
for
non­
vascular
aquatic
plants
to
31
for
vascular
aquatic
plants
and
from
7.6
to
50
for
endangered
vascular
aquatic
plants.
The
non­
target
endangered
and
non­
endangered
aquatic
plant
RQs
resulting
from
the
terrestrial
uses
range
from
<
0.01
for
non­
vascular
plants
to
4.7
for
vascular
aquatic
plants
and
from
0.07
to
7.6
for
endangered
vascular
aquatic
plants.
The
Agency
has
determined
that
the
specific
drift
requirements
listed
above
will
substantially
reduce
the
risks
to
non­
target
aquatic
plants
from
terrestrial
uses
of
imazapyr.

For
non­
target
plant
risks
resulting
from
the
aquatic
use
of
imazapyr,
there
is
currently
the
statement,
"
Do
not
apply
to
bodies
of
water
or
portions
of
bodies
of
water
where
emergent
and/
or
floating
weeds
do
not
exist"
on
labels
that
allow
application
to
water
bodies.
The
Agency
believes
that
this
statement
also
substantially
reduces
the
risks
to
non­
target
aquatic
plants
(
including
endangered
plants)
from
this
use.
However,
the
Agency
feels
that
this
language
should
be
placed
in
a
more
prominent
location
on
the
label.
Therefore,
the
Agency
is
requiring
the
statement
be
placed
in
the
General
Use
Precautions
and
Restrictions
section
of
the
label.
Putting
this
use
requirement
in
this
section
will
make
it
clearer
that
this
is
a
use
restriction
when
applying
to
bodies
of
water.
Currently,
this
statement
is
in
the
General
Information
section
of
the
label.
33
3.
Significance
of
Imazapyr
Use
The
application
of
imazapyr
for
aquatic
and
semi­
aquatic
weed
control
is
predominantly
conducted
to
control
nuisance
and
nonnative
weed
species;
most
often
species
such
as
Purple
Loosestrife
(
Lythrum
salicaria
L.).
When
these
species
begin
to
invade
shoreline
areas
of
lakes,
streams,
or
canals,
their
establishment
is
rapid
and
often
results
in
their
out­
competing
indigenous
species,
which
then
leads
to
a
monoculture.
Since
imazapyr
has
no
effect
on
submerged
aquatic
vegetation
(
SAV),
it
can
be
used
in
these
margin,
or
shoreline,
areas
to
control
weeds
without
the
risk
of
damaging
desirable
SAV.

4.
Other
Labeling
Requirements
In
order
to
be
eligible
for
reregistration,
imazapyr
use
and
safety
information
will
be
included
in
the
labeling
of
all
end­
use
products
containing
imazapyr.
Imazapyr
is
classified
as
a
Toxicity
Category
I
primary
eye
irritant;
therefore,
the
WPS
requires
a
REI
of
48
hours.
Also
under
the
WPS,
early
entry
requires
that
coveralls,
shoes
and
socks,
chemical
resistant
gloves,
and
protective
eyewear
be
used.

For
the
specific
labeling
statements
and
a
list
of
outstanding
data,
refer
to
Section
V
of
this
RED
document.

5.
Threatened
and
Endangered
Species
Considerations
a.
The
Endangered
Species
Program
The
Agency
has
developed
the
Endangered
Species
Protection
Program
to
identify
pesticides
whose
use
may
cause
adverse
impacts
on
threatened
and
endangered
species,
and
to
implement
mitigation
measures
that
address
these
impacts.
The
Endangered
Species
Act
requires
federal
agencies
to
ensure
that
their
actions
are
not
likely
to
jeopardize
listed
species
or
adversely
modify
designated
critical
habitat.
To
analyze
the
potential
of
registered
pesticide
uses
that
may
affect
any
particular
species,
the
Agency
uses
basic
toxicity
and
exposure
data
developed
for
the
REDs
and
then
considers
ecological
parameters,
pesticide
use
information,
geographic
relationship
between
specific
pesticide
uses
and
species
locations,
and
biological
requirements
and
behavioral
aspects
of
the
particular
species.
When
conducted,
this
species­
specific
analysis
will
also
consider
the
risk
mitigation
measures
that
are
being
implemented
as
a
result
of
this
RED.

Following
this
future
species­
specific
analysis,
a
determination
that
there
is
a
likelihood
of
potential
effects
to
a
listed
species
may
result
in
limitations
on
use
of
the
pesticide,
other
measures
to
mitigate
any
potential
effects,
or
consultations
with
the
Fish
and
Wildlife
Service
and/
or
the
National
Marine
Fisheries
as
appropriate.
If
the
Agency
determines
use
of
imazapyr
"
may
effect"
listed
species
or
their
designated
critical
habitat,
the
Agency
will
employ
the
provisions
in
the
Services
regulations
(
50
CFR
Part
402).
Until
the
species­
specific
analysis
is
completed,
the
risk
mitigation
measures
being
implemented
through
this
RED
will
reduce
the
likelihood
that
endangered
and
threatened
species
may
be
exposed
to
imazapyr
at
levels
of
concern.
The
Agency
is
not
requiring
34
specific
imazapyr
label
language
at
the
present
time
relative
to
threatened
and
endangered
species.
If,
in
the
future,
specific
measures
are
necessary
for
the
protection
of
listed
species,
the
Agency
will
implement
them
through
the
Endangered
Species
Program.

b.
General
Risk
Mitigation
Imazapyr
end­
use
products
(
EUPs)
may
also
contain
other
registered
pesticides.
Although
the
Agency
is
not
proposing
any
mitigation
measures
for
products
containing
imazapyr
specific
to
federally
listed
threatened
and
endangered
species,
the
Agency
needs
to
address
potential
risks
from
other
end­
use
products.
Therefore,
the
Agency
requires
that
users
adopt
all
threatened
and
endangered
species
risk
mitigation
measures
for
all
active
ingredients
in
the
product.
If
a
product
contains
multiple
active
ingredients
with
conflicting
threatened
and
endangered
species
risk
mitigation
measures,
the
more
stringent
measure(
s)
must
be
adopted.

V.
What
Registrants
Need
to
Do
The
Agency
has
determined
that
imazapyr
is
eligible
for
reregistration
provided
that
the
risk
mitigation
measures
identified
in
this
document
are
adopted
and
label
amendments
are
made
to
reflect
these
measures;
however,
additional
data
are
required
to
confirm
this
decision.
In
the
near
future,
the
Agency
intends
to
issue
Data
Call­
In
Notices
(
DCIs)
requiring
product
specific
data
and
generic
(
technical
grade)
data.
Generally,
registrants
will
have
90
days
from
receipt
of
a
DCI
to
complete
and
submit
response
forms
or
request
time
extension
and/
or
waiver
requests
with
a
full
written
justification.
For
product
specific
data,
the
registrant
will
have
8
months
to
submit
data
and
amend
labels.
For
generic
data,
due
dates
can
vary
depending
on
the
specific
studies
being
required.
Below
are
tables
of
additional
generic
data
that
the
Agency
intends
to
require
for
imazapyr
to
be
eligible
for
reregistration.

A.
Manufacturing
Use
Products
1.
Additional
Generic
Data
Requirements
The
generic
database
supporting
the
reregistration
of
imazapyr
has
been
reviewed
and
determined
to
be
substantially
complete.
However,
the
following
additional
data
requirements
have
been
identified
by
the
Agency
as
confirmatory
and
are
included
in
the
generic
DCI
for
this
RED.
35
Table
14.
Confirmatory
Data
Requirements
for
Reregistration
New
Guideline
Number
Old
Guideline
Number
Study/
Requirements
123­
1(
a)
850.4225
Seedling
Emergence­
Tier
II
using
Imazapyr
isopropylamine
salt
PLUS
the
adjuvant/
surfactant/
wetting
agent
as
required
on
the
label
123­
1(
b)
850.4250
Vegetative
Vigor­
Tier
II
using
Imazapyr
isopropylamine
salt
PLUS
the
adjuvant/
surfactant/
wetting
agent
as
required
on
the
label
171­
4e
860.1380
Storage
stability
data
for
corn
or
grass
171­
4f,
g,
h,
165­
5
860.1400
Magnitude
of
residues
in
fish
171­
4k
860.1500
Identity
and
quantity
of
spray
additives
used
in
all
of
the
grass
field
trials
Imazapyr
is
registered
for
use
on
aquatic
areas
and
the
treated
water
from
these
sites
may
be
diverted
to
irrigate
food
or
feed
crops.
No
data
depicting
imazapyr
residue
levels
in
irrigated
crops
have
been
submitted
and
presently
no
label
restriction
prohibits
use
of
imazapyr
treated
waters
for
irrigated
crops.
Data
on
irrigated
crops
or
label
restrictions
that
prohibit
the
irrigation
of
crops
with
imazapyr
treated
water
for
120
days
following
application
and/
or
demonstrates
non­
detectable
residue
levels
of
imazapyr
in
irrigation
water
by
laboratory
analysis
prior
to
use
are
required
to
confirm
this
for
reregistration
decision.

2.
Labeling
for
Technical
and
Manufacturing
Use
Products
To
ensure
compliance
with
FIFRA,
technical
and
manufacturing
use
products
(
MP)
labeling
should
be
revised
to
comply
with
all
current
EPA
regulations,
PR
Notices
and
applicable
policies.
In
order
to
be
eligible
for
reregistration,
amend
all
product
labels
to
incorporate
the
risk
mitigation
measures
outlined
in
Section
IV.
The
technical
and
MP
labeling
should
also
bear
the
labeling
statements
contained
in
Table
15,
Label
Changes
Summary
Table.

B.
End­
Use
Products
1.
Additional
Product­
Specific
Data
Requirements
Section
4(
g)
(
2)
(
B)
of
FIFRA
calls
for
the
Agency
to
obtain
any
needed
productspecific
data
regarding
the
pesticides
after
a
determination
of
eligibility
has
been
made.
The
registrant
must
review
previous
data
submissions
to
ensure
they
meet
current
EPA
acceptance
criteria
and
if
not,
commit
to
conduct
new
studies.
If
a
registrant
believes
that
previously
submitted
data
meet
current
testing
standards,
then
the
study
MRID
numbers
should
be
cited
according
to
the
instructions
in
the
Requirement
Status
and
Registrations
Response
Form
provided
for
each
product.

A
product­
specific
data
call­
in,
outlining
specific
data
requirements
will
be
issued
in
the
near
future.
36
2.
Labeling
for
End­
Use
Products
Labeling
changes
are
necessary
to
implement
measures
outlined
in
Section
IV
above.
Specific
language
to
incorporate
these
changes
is
specified
in
the
Label
Changes
Summary
Table
below.

a.
Label
Changes
Summary
Table
In
order
to
be
eligible
for
reregistration,
registrants
must
amend
all
product
labels
to
incorporate
the
risk
mitigation
measures
outlined
in
Section
IV.
The
following
table
describes
how
language
on
the
labels
should
be
amended.
37
Table
15:
Summary
of
Labeling
Changes
for
Imazapyr
Description
Amended
Labeling
Language
Placement
on
Label
For
all
Manufacturing
Use
Products
"
Only
for
formulation
into
an
herbicide
for
the
following
uses:

liquid,
wettable
powder
(
in
water
soluble
bags
only),
and
granular."

"
Not
for
formulation
into
wettable
powder
end
use
products
unless
they
are
packaged
in
water
soluble
bags."
Directions
for
Use
One
of
these
statements
may
be
added
to
a
label
to
allow
reformulation
of
the
product
for
a
specific
use
or
all
additional
uses
supported
by
a
formulator
or
user
group
"
This
product
may
be
used
to
formulate
products
for
specific
use(
s)

not
listed
on
the
MP
label
if
the
formulator,
user
group,
or
grower
has
complied
with
U.
S.
EPA
submission
requirements
regarding
support
of
such
use(
s)."

"
This
product
may
be
used
to
formulate
products
for
any
additional
use(
s)
not
listed
on
the
MP
label
if
the
formulator,
user
group,
or
grower
has
complied
with
U.
S.
EPA
submission
requirements
regarding
support
of
such
use(
s)."
Directions
for
Use
Environmental
Hazards
"
This
product
is
toxic
to
plants.
Drift
and
run­
off
may
be
hazardous
to
plants
in
water
adjacent
to
treated
areas.
Do
not
apply
to
water
except
as
specified
on
the
label.
Treatment
of
aquatic
weeds
may
result
in
oxygen
depletion
or
loss
due
to
decomposition
of
dead
plants.
Do
not
treat
more
than
one
half
the
surface
area
of
the
water
in
a
single
operation
and
wait
at
least
10
to
14
days
between
treatments.
Begin
treatment
along
the
shore
and
proceed
outward
in
bands
to
allow
aquatic
organisms
to
move
into
untreated
areas.
Do
not
contaminate
water
when
disposing
of
equipment,
washwater,
or
rinsate.
See
Directions
for
Use
for
additional
precautions
and
requirements."
Precautionary
Statements
38
End
Use
Products
for
Occupational
Use
(
WPS
and
non­
WPS)

PPE
Requirements
Established
by
the
RED1
For
All
Formulations
"
Personal
Protective
Equipment
(
PPE)

Some
materials
that
are
chemical­
resistant
to
this
product
are
@

(
registrant
inserts
correct
chemical­
resistant
material).
A
If
you
want
more
options,
follow
the
instructions
for
category
@
[
registrant
inserts
A,
B,
C,
D,
E,
F,
G,
or
H]
A
on
an
EPA
chemical­
resistance
category
selection
chart.

"
Mixers,
loaders,
applicators,
and
other
handlers
must
wear:

>
Long­
sleeve
shirt
and
long
pants,

>
Shoes
plus
socks,

>
Chemical
resistant
gloves
for
all
mixers
and
loaders,
plus
applicators
using
handheld
equipment."
Precautionary
Restrictions
User
Safety
Requirements
"
Follow
manufacturer's
instructions
for
cleaning/
maintaining
PPE.
If
no
such
instructions
for
washables
exist,
use
detergent
and
hot
water.

Keep
and
wash
PPE
separately
from
other
laundry.

Discard
clothing
and
other
absorbent
materials
that
have
been
drenched
or
heavily
contaminated
with
this
product
=
s
concentrate.
Do
not
reuse
them."
Immediately
following
the
PPE
requirements
Engineering
controls
for
Products
Applied
Aerially
as
Sprays
"
Pilots
must
use
an
enclosed
cockpit
that
meet
the
requirements
listed
in
the
Worker
Protection
Standard
(
WPS)
for
agricultural
pesticides
[
40
CFR
170.240(
d)(
6)]."
Immediately
following
the
User
Safety
Requirements
39
User
Safety
Recommendations
"
User
Safety
Recommendations
Users
should
wash
hands
with
plenty
of
soap
and
water
before
eating,

drinking,
chewing
gum,
using
tobacco,
or
using
the
toilet.

Users
should
remove
clothing/
PPE
immediately
if
pesticide
gets
inside.
Then
wash
thoroughly
and
put
on
clean
clothing.

Users
should
remove
PPE
immediately
after
handling
this
product.

Wash
the
outside
of
gloves
before
removing.
As
soon
as
possible,

wash
thoroughly
and
change
into
clean
clothing."
Immediately
following
Engineering
Controls
(
Must
be
placed
in
a
box.)

Environmental
Hazards
"
This
product
is
toxic
to
plants.
Drift
and
run­
off
may
be
hazardous
to
plants
in
water
adjacent
to
treated
areas.
Do
not
apply
to
water
except
as
specified
on
the
label.
Treatment
of
aquatic
weeds
may
result
in
oxygen
depletion
or
loss
due
to
decomposition
of
dead
plants.
Do
not
treat
more
than
one
half
the
surface
area
of
the
water
in
a
single
operation
and
wait
at
least
10
to
14
days
between
treatments.
Begin
treatment
along
the
shore
and
proceed
outward
in
bands
to
allow
aquatic
organisms
to
move
into
untreated
areas.
Do
not
contaminate
water
when
disposing
of
equipment,
washwater,
or
rinsate.
See
Directions
for
Use
for
additional
precautions
and
requirements."
Precautionary
Statements
immediately
following
the
User
Safety
Recommendations
Restricted­
Entry
Interval
for
products
with
directions
for
use
within
scope
of
the
Worker
Protection
Standard
for
Agricultural
Pesticides
(
WPS)
"
Do
not
enter
or
allow
worker
entry
into
treated
areas
during
the
restricted
entry
interval
(
REI)
of
48
hours."
Directions
for
Use,
In
Agricultural
Use
Requirements
Box
40
Entry
Restrictions
for
Products
with
Directions
for
Use
not
Within
the
Scope
of
WPS
For
products
applied
as
Sprays:
"
Do
not
enter
or
allow
others
to
enter
treated
areas
until
sprays
have
dried"

For
products
applied
as
Dry:
"
Do
not
enter
or
allow
others
to
enter
treated
areas
until
dusts
have
settled."

Early
Entry
Personal
Protective
Equipment
for
products
with
directions
for
use
within
the
scope
of
the
WPS
"
PPE
required
for
early
entry
to
treated
areas
that
is
permitted
under
the
Worker
Protection
Standard
and
that
involves
contact
with
anything
that
has
been
treated,
such
as
plants,
soil,
or
water,
is:

*
coveralls
*
shoes
plus
socks
*
chemical­
resistant
gloves
made
of
any
waterproof
material
*
protective
eyewear"
Direction
for
Use,
In
Agricultural
Use
Requirements
box,
immediately
following
the
REI
General
Application
Restrictions
"
Do
not
apply
this
product
in
a
way
that
will
contact
workers
or
other
persons,
either
directly
or
through
drift.
Only
protected
handlers
may
be
in
the
area
during
application."
Place
in
the
Direction
for
Use
directly
above
the
Agricultural
Use
Box.

Spray
Drift
Spray
drift
requirements
Aerial
Applications:

(
1)
Applicators
are
required
to
use
a
Coarse
or
coarser
droplet
size
(
ASABE
S572)
or,
if
specifically
using
a
spinning
atomizer
nozzle,

applicators
are
required
to
use
a
volume
mean
diameter
(
VMD)
of
385
microns
or
greater
for
release
heights
below
10
feet;
Applicators
are
required
to
use
a
Very
Coarse
or
coarser
droplet
size
or,
if
specifically
using
a
spinning
atomizer
nozzle,
applicators
are
required
to
use
a
VMD
of
475
microns
or
greater
for
release
heights
above
10
feet;
Applicators
must
consider
the
effects
of
nozzle
orientation
and
flight
speed
when
determining
droplet
size.
Directions
for
Use
41
(
2)
Applicators
are
required
to
use
upwind
swath
displacement.

(
3)
The
boom
length
must
not
exceed
60%
of
the
wingspan
or
90%
of
the
rotor
blade
diameter
to
reduce
spray
drift.

(
4)
Applications
with
wind
speeds
less
than
3
mph
and
with
wind
speeds
greater
than
10
mph
are
prohibited.

(
5)
Applications
into
temperature
inversions
are
prohibited.

Ground
Boom
Applications:

(
1)
Applicators
are
required
to
use
a
nozzle
height
below
4
feet
above
the
ground
or
plant
canopy
and
Coarse
or
coarser
droplet
size
(
ASABE
S572)
or,
if
specifically
using
a
spinning
atomizer
nozzle,

applicators
are
required
to
use
a
volume
mean
diameter
(
VMD)
of
385
microns
or
greater.

(
2)
Applications
with
wind
speeds
greater
than
10
mph
are
prohibited.

(
3)
Applications
into
temperature
inversions
are
prohibited.

The
use
of
treated
waters
on
irrigated
crops
within
120
days
of
treatment
is
prohibited.
42
End
Use
Products
Primarily
Intended
for
Residential
Use
Environmental
Hazard
Statements
"
This
product
is
toxic
to
plants.
Drift
and
run­
off
may
be
hazardous
to
plants
in
water
adjacent
to
treated
areas.
Do
not
apply
to
water
except
as
specified
on
the
label.
Treatment
of
aquatic
weeds
may
result
in
oxygen
depletion
or
loss
due
to
decomposition
of
dead
plants.
Do
not
treat
more
than
one
half
the
surface
area
of
the
water
in
a
single
operation
and
wait
at
least
10
to
14
days
between
treatments.
Begin
treatment
along
the
shore
and
proceed
outward
in
bands
to
allow
aquatic
organisms
to
move
into
untreated
areas.
Do
not
contaminate
water
when
disposing
of
equipment,
washwater,
or
rinsate.
See
Directions
for
Use
for
additional
precautions
and
requirements."
Precautionary
Statements
immediately
following
the
User
Safety
Recommendations
Entry
Restrictions
for
products
applied
as
a
spray
For
products
applied
as
Sprays:
"
Do
not
enter
or
allow
others
to
enter
treated
areas
until
sprays
have
dried"

For
products
applied
as
Dry:
"
Do
not
enter
or
allow
others
to
enter
treated
areas
until
dusts
have
settled."
Directions
for
use
under
General
Precautions
and
Restrictions
General
Application
Restrictions
"
Do
not
apply
this
product
in
a
way
that
will
contact
any
person,
pet,

either
directly
or
through
drift.
Keep
people
and
pets
out
of
the
area
during
application."
Directions
for
Use
under
General
Precautions
and
Restrictions
1
PPE
that
is
established
on
the
basis
of
Toxicity
of
the
end­
use
product
must
be
compared
to
the
active
ingredient
PPE
in
this
document.
The
more
protective
PPE
must
be
placed
in
the
product
labeling.
For
guidance
on
which
PPE
is
considered
more
protective,
see
PR
Notice
93­
7.

2
If
the
product
contains
oil
or
bears
instructions
that
will
allow
application
with
an
oil­
containing
material,
the
A
N
@
designation
must
be
dropped.
43
VI.
Appendices
44
Appendix
A.
IMAZAPYR
USE
PATTERNS
ELIGIBLE
FOR
REREGISTRATION
Site
Application
Type
Application
Timing
Application
Equipment
Formulation
[
EPA
Reg.

No.]
Max.
Single
Application
Rate
(
lb
ae/
A)
Max.
#

Apps./
season
Minimum
Retreatment
Interval
(
Days)
Use
Limitations
Noncropland
Areas
Pre­
emergence
aerial,
tractor­
drawn
spreader
0.5%
granular
[
228­
307]
1.5
1
(
herbaceous)

1­
2
per
10
years
(
brush)
N/
S
Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present,
or
to
intertidal
areas
below
the
mean
high
water
mark.
Do
not
use
on
food
or
feed
crops.
Do
not
treat
irrigation
ditches,
or
water
used
for
crop
irrigation
or
for
domestic
uses.
Do
not
appy
where
runoff
or
irrigation
water
may
flow
onto
agricultural
land.
Do
not
use
on
lawns,
walks,
driveways
tennis
cours,
or
similar
areas.
Do
not
use
in
California.

Noncropland
Areas
Pre­
emergence
aerial,
tractor­
drawn
spreader
0.5%
granular
[
228­
308]
1.5
1
(
herbaceous)

1­
2
per
10
years
(
brush)
N/
S
Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present,
or
to
intertidal
areas
below
the
mean
high
water
mark.
Do
not
use
on
food
or
feed
crops.
Do
not
treat
irrigation
ditches,
or
water
used
for
crop
irrigation
or
for
domestic
uses.
Do
not
appy
where
runoff
or
irrigation
water
may
flow
onto
agricultural
land.
Do
not
use
on
lawns,
walks,
driveways
tennis
cours,
or
similar
areas.
Do
not
use
in
California.

Noncropland
Areas
Pre­
emergence
aerial,
tractor­
drawn
spreader
0.5%
granular
[
241­
295]
1.5
1
(
herbaceous)

1­
2
per
10
years
(
brush)
N/
S
Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present,
or
to
intertidal
areas
below
the
mean
high
water
mark.
Do
not
use
on
food
or
feed
crops.
Do
not
treat
irrigation
ditches,
or
water
used
for
crop
irrigation
or
for
domestic
uses.
Do
not
appy
where
runoff
or
irrigation
water
may
flow
onto
agricultural
land.
Do
not
use
on
lawns,
walks,
driveways
tennis
cours,
or
similar
areas.
Do
not
use
in
California.

Noncropland
Areas
Pre­
emergence
aerial,
tractor­
drawn
spreader
5.0%
granular
[
241­
308]
1.5
1
(
herbaceous)

1­
2
per
10
years
(
brush)
N/
S
Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present,
or
to
intertidal
areas
below
the
mean
high
water
mark.
Do
not
use
on
food
or
feed
crops.
Do
not
treat
irrigation
ditches,
or
water
used
for
crop
irrigation
or
for
domestic
uses.
Do
not
appy
where
runoff
or
irrigation
water
may
flow
onto
agricultural
land.
Do
not
use
on
lawns,
walks,
driveways
tennis
cours,
or
similar
areas.
Do
not
use
in
California.

Noncropland
Areas
Pre­
emergence
aerial,
tractor­
drawn
spreader
0.5%
granular
[
241­
344]
1.5
1
(
herbaceous)

1­
2
per
10
years
(
brush)
N/
S
Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present,
or
to
intertidal
areas
below
the
mean
high
water
mark.
Do
not
use
on
food
or
feed
crops.
Do
not
treat
irrigation
ditches,
or
water
used
for
crop
irrigation
or
for
domestic
uses.
Do
not
appy
where
runoff
or
irrigation
water
may
flow
onto
agricultural
land.
Do
not
use
on
lawns,
walks,
driveways
tennis
cours,
or
similar
areas.
Do
not
use
in
California.

Noncropland
Areas
Pre­
emergence
Aerial,
groundboom,

low­
pressure
handwand,

right­
of­
way
sprayer,

backpack
7.78%
dispersable
granules
[
241­
372]
1.5
initial
application
0.5
reapplication
1.5
lb
ae/
A
in
a
12
month
period
N/
S
Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present,
or
to
intertidal
areas
below
the
mean
high
water
mark.
Do
not
use
on
food
or
feed
crops.
Do
not
treat
irrigation
ditches,
or
water
used
for
crop
irrigation
or
for
domestic
uses.
Do
not
use
on
lawns,
walks,
driveways
tennis
cours,
or
similar
areas.
Do
not
use
in
California.
45
Site
Application
Type
Application
Timing
Application
Equipment
Formulation
[
EPA
Reg.

No.]
Max.
Single
Application
Rate
(
lb
ae/
A)
Max.
#

Apps./
season
Minimum
Retreatment
Interval
(
Days)
Use
Limitations
Clearfield
Corn
Hybrids
Post­
emergence
Backpack,
low­
pressure,

handgun,
airblast,
aerial
17.5%
dispersable
granules
[
241­
377]
0.014
1
N/
S
Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present,
or
to
intertidal
areas
below
the
mean
high
water
mark.
Do
not
apply
through
any
type
of
irrigation
system.
Do
not
use
in
California.
New
York
­
Not
for
sale
or
use
on
Long
Island
Clearfield
Corn
Hybrids
Post­
emergence
Backpack,
low­
pressure,

handgun,
airblast,
aerial
4.0%
dispersable
granules
[
241­
384]
0.014
1
N/
S
Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present,
or
to
intertidal
areas
below
the
mean
high
water
mark.
Do
not
apply
through
any
type
of
irrigation
system.
Do
not
use
in
California.
New
York
­
Not
for
sale
or
use
on
Long
Island
Trees
Post­
emergence
Aerial,
groundboom,

handgun,
rights­
of­
way
sprayer
75%
soluble
granules
[
241­
387]
1.5
1
(
herbaceous)

1­
2
per
10
years
(
brush)
N/
S
Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present,
or
to
intertidal
areas
below
the
mean
high
water
mark.
Do
not
use
on
food
or
feed
crops.
Do
not
treat
irrigation
ditches,
or
water
used
for
crop
irrigation
or
for
domestic
uses.
Do
not
use
on
lawns,
walks,
driveways
tennis
cours,
or
similar
areas.
Do
not
use
in
California.

Clearfield
Corn
Hybrids
Post­
emergence
Aerial,
groundboom,

low­
pressure
handwand,

right­
of­
way
sprayer,

backpack
5.05%
liquid
[
241­
400]
0.014
1
N/
S
Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present,
or
to
intertidal
areas
below
the
mean
high
water
mark.
Do
not
mix
or
load
within
50
feet
of
any
wells,
sink
holes,
perennial
or
intermittent
streams
and
rivers,
and
natural
or
impounded
reservoirs.
Not
for
use
in
California
or
New
York.

Trees
Post­
emergence
Aerial,
groundboom,

handgun,
rights­
of­
way
sprayer
75.0%
soluble
granules
[
241­
402]
1.25
1
(
herbaceous)

1­
2
per
10
years
(
brush)
N/
S
Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present,
or
to
intertidal
areas
below
the
mean
high
water
mark.
Do
not
use
on
food
or
feed
crops.
Do
not
use
on
Christmas
trees.
Do
not
treat
irrigation
ditches,
or
water
used
for
crop
irrigation
or
for
domestic
uses.

Noncropland
Areas
Pre­
emergence
Aerial,
groundboom,

low­
pressure
handwand,

right­
of­
way
sprayer,

backpack
0.15%
liquid
[
2217­
802]
0.014
1
N/
S
Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present,
or
to
intertidal
areas
below
the
mean
high
water
mark.
Do
not
apply
through
any
irrigation
system.

Noncropland
Areas
Pre­
emergence
aerial,
tractor­
drawn
spreader
0.5%
granules
[
13283­
19]
1.5
1
(
herbaceous)

1­
2
per
10
years
(
brush)
N/
S
Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present,
or
to
intertidal
areas
below
the
mean
high
water
mark.
Do
not
use
on
food
or
feed
crops.
Do
not
treat
irrigation
ditches,
or
water
used
for
crop
irrigation
or
for
domestic
uses.
46
Noncropland
Areas
Pre­
emergence
aerial,
tractor­
drawn
spreader
0.5%
granules
[
34913­
22]
1.5
1
(
herbaceous)

1­
2
per
10
years
(
brush)
N/
S
Do
not
apply
directly
to
water,
or
to
areas
where
surface
water
is
present,
or
to
intertidal
areas
below
the
mean
high
water
mark.
Do
not
use
on
food
or
feed
crops.
Do
not
treat
irrigation
ditches,
or
water
used
for
crop
irrigation
or
for
domestic
uses.
Do
not
use
on
lawns,
walks,
driveways
tennis
cours,
or
similar
areas.
Do
not
use
in
California.

Noncropland
Areas
Pre­
emergence
aerial,
tractor­
drawn
spreader
5%
granules
[
34913­
24]
1.5
1
(
herbaceous)

1­
2
per
10
years
(
brush)
N/
S
Do
not
use
on
food
or
feed
crops.
Do
not
apply
on
ditches
used
to
transport
irrigation
water.
Do
not
apply
where
runoff
or
irrigation
water
may
flow
onto
agricultural
land.
Do
not
use
on
lawns,
walks,
driveways,
tennis
courts,
or
similar
areas.

Grass
Pasture
and
Rangeland
Post­
emergence
Spot
treatment
ground
equipment
2
lb
ae/
gal
EC
[
241­
346]
0.75
1
per
5
years
7­
day
PHI2
Applications
may
not
exceed
more
than
1/
10
of
a
given
acre,
therefore
the
maximum
rate
per
acre
is
0.075
lb
ae/
A.
Do
not
cut
forage
for
hay
for
7
days
after
application.
Rotational
crops:
12
months
after
application,
a
successful
field
bioassay
must
be
completed.
If
no
crop
injury
is
evident
in
the
bioassay,

then
the
intended
rotational
crop
may
be
planted
the
following
year.

Postemergence
applications
require
the
addition
of
a
spray
adjuvant
(
nonionic
surfactant
or
methylated
seed
oils
or
vegetable
oil
concentrates).

Aquatic
Areas
or
Draw
Down
Area
Post­
emergence
Aerial,
boat
2
lb
ae/
gal
EC
[
241­
346]
1.5
N/
S
N/
S
Do
not
apply
to
marine
or
estuarine
areas.
Do
not
apply
within
½
mile
(
standing
water)
or
within
½
mile
upstreat
(
flowing
water)
of
an
active
irrigation
or
potable
water
intake.
For
application
within
½
mile
of
a
water
intake,
the
water
intake
must
be
turned
off
for
a
minimum
of
48
hours
after
the
application.
Allow
1
hour
after
treatment
before
refilling
draw
down
area.

Apply
in
a
minimum
of
value
of
5
gal/
A.

1.
N/
S 
not
specified
2.
PHI 
post­
harvest
interval
47
Appendix
B.
TABLE
OF
GENERIC
DATA
REQUIREMENTS
AND
STUDIES
USED
TO
MAKE
THE
REREGISTRATION
DECISION
GUIDE
TO
APPENDIX
B
Appendix
B
contains
listing
of
data
requirements
which
support
the
reregistration
for
active
ingredients
within
Case
#
3078
(
Imazapyr)
covered
by
this
RED.
It
contains
generic
data
requirements
that
apply
to
Imazapyr
in
all
products,
including
data
requirements
for
which
a
"
typical
formulation"
is
the
test
substance.
The
data
table
is
organized
in
the
following
formats:
1.
Data
Requirement
(
Column
1).
The
data
requirements
are
listed
in
the
order
in
which
they
appear
in
40
CFR
part
158.
The
reference
numbers
accompanying
each
test
refer
to
the
test
protocols
set
in
the
Pesticide
Assessment
Guidance,
which
are
available
from
the
National
technical
Information
Service,
5285
Port
Royal
Road,
Springfield,
VA
22161
(
703)
487­
4650.

2.
Use
Pattern
(
Column
2).
This
column
indicates
the
use
patterns
for
which
the
data
requirements
apply.
The
following
letter
designations
are
used
for
the
given
use
patterns.
A.
Terrestrial
food
B.
Terrestrial
feed
C.
Terrestrial
non­
food
D.
Aquatic
food
E.
Aquatic
non­
food
outdoor
F.
Aquatic
non­
food
industrial
G.
Aquatic
non­
food
residential
H.
Greenhouse
food
I.
Greenhouse
non­
food
J.
Forestry
K.
Residential
L.
Indoor
food
M.
Indoor
non­
food
N.
Indoor
medical
O.
Indoor
residential
3.
Bibliographic
Citation
(
Column
3).
If
the
Agency
has
acceptable
data
in
its
files,
this
column
list
the
identify
number
of
each
study.
This
normally
is
the
Master
Record
Identification
(
MIRD)
number,
but
may
be
a
"
GS"
number
if
no
MRID
number
has
been
assigned.
Refer
to
the
Bibliography
appendix
for
a
complete
citation
of
the
study.
48
New
Guideline
Number
Old
Guideline
Number
Requirement
Use
Pattern
Bibliographic
Citation(
s)

PRODUCT
CHEMISTRY
830.1550
61­
1
Product
Identity
and
Composition
A,
B,
C,
E,
F,

G,
J,
K
43423700,
43423701
830.1600
61­
2(
a)
Start.
Mat.
&
Mfg.
Process
A,
B,
C,
E,
F,

G,
J,
K
43423700
830.1620
61­
2(
b)
Description
of
Production
Process
A,
B,
C,
E,
F,

G,
J,
K
43423700
830.1650
158.165
Description
of
Formulation
Process
A,
B,
C,
E,
F,

G,
J,
K
43423700
830.1670
61­
2(
b)
Discussion
of
Formation
of
Impurities
A,
B,
C,
E,
F,

G,
J,
K
43423701­
03
830.1700
62­
1
Preliminary
Analysis
A,
B,
C,
E,
F,

G,
J,
K
43423702
830.1750
62­
2
Certification
of
limits
A,
B,
C,
E,
F,

G,
J,
K
46274402
830.1800
62­
3
Analytical
Method
A,
B,
C,
E,
F,

G,
J,
K
44102801
830.6302
63­
2
Color
A,
B,
C,
E,
F,

G,
J,
K
00145872
830.6303
63­
3
Physical
State
A,
B,
C,
E,
F,

G,
J,
K
00145872
49
830.6304
63­
4
Odor
A,
B,
C,
E,
F,

G,
J,
K
00145872
830.6313
63­
13
Stability
­
temp
and
ions
A,
B,
C,
E,
F,

G,
J,
K
00145872
830.7000
63­
12
pH
A,
B,
C,
E,
F,

G,
J,
K
00145872
830.7050
N/
A
UV/
Visible
absorption
A,
B,
C,
E,
F,

G,
J,
K
Data
Gap
830.7200
63­
5
Melting
point/
melting
range
A,
B,
C,
E,
F,

G,
J,
K
00145872
830.7220
63­
6
Boiling
point/
range
A,
B,
C,
E,
F,

G,
J,
K
N/
A
830.7300
63­
7
Density
A,
B,
C,
E,
F,

G,
J,
K
00145872
830.7370
63­
10
Dissociation
Constants
in
Water
A,
B,
C,
E,
F,

G,
J,
K
00145872
830.7550
63­
11
Partition
Coefficient,
shake
flask
method
A,
B,
C,
E,
F,

G,
J,
K
00145872,
00133555
830.7560
63­
11
Partition
Coefficient,
generator
column
method
A,
B,
C,
E,
F,

G,
J,
K
See
830.7550
830.7570
63­
11
Partition
Coefficient,
estimation
by
liquid
chromatography
A,
B,
C,
E,
F,

G,
J,
K
See
830.7550
830.7840
63­
8
Water
Solubility,
column
elution
method;
shake
flask
method
A,
B,
C,
E,
F,

G,
J,
K
See
830.7860
830.7860
63­
8
Water
Solubility,
generator
column
method
A,
B,
C,
E,
F,

G,
J,
K
00145872
50
830.7950
63­
9
Vapor
Pressure
A,
B,
C,
E,
F,

G,
J,
K
00145782
ECOLOGICAL
EFFECTS
850.2100
71­
1(
a)
Avian
Oral
LD50
Quail/
Duck
A,
B,
C,
E,
F,

G,
J,
K
00131633,
00131634
850.2200
71­
2(
a)
Avian
Dietary
LC50
Quail
A,
B,
C,
E,
F,

G,
J,
K
00131635,
0013552,
00133553
850.2200
71­
2(
b)
Avian
Dietary
LC50
Duck
A,
B,
C,
E,
F,

G,
J,
K
00131636,
00131551
850.2300
71­
4(
a)
Avian
Reproduction
Quail
A,
B,
C,
E,
F,

G,
J,
K
45119714,
43831401
850.2300
71­
4(
b)
Avian
Reproduction
Duck
A,
B,
C,
E,
F,

G,
J,
K
43831402
850.1075
72­
1(
a)
Freshwater
Fish
LC50
Bluegill
(
warm
water)
A,
B,
C,
E,
F,

G,
J,
K
00133549
850.1075
72­
1(
b)
Freshwater
Fish
LC50
Channel
Catfish
A,
B,
C,
E,
F,

G,
J,
K
00131631
850.1075
72­
1(
c)
Freshwater
Fish
LC50
Rainbow
trout
(
cold
water)
A,
B,
C,
E,
F,

G,
J,
K
45119713
850.1010
72­
2(
a)
Freshwater
Invertebrate
LC50
Daphnia
magna
A,
B,
C,
E,
F,

G,
J,
K
00131632,
01133550
850.1045
72­
3(
a)
Estuarine/
Marine
Fish
LC50
A,
B,
C,
E,
F,

G,
J,
K
41315801
850.1025
72­
3(
b)
Estuarine/
Marine
Mollusk
EC50
A,
B,
C,
E,
F,

G,
J,
K
41315802,
45119709,
45119710
850.1035
72­
3(
c)
Estuarine/
Marine
Shrimp
EC50
A,
B,
C,
E,
F,

G,
J,
K
41315803
51
850.1400
72­
4(
a)
Fish
Early
Life­
Stage
Rainbow
Trout
(
freshwater)
A,
B,
C,
E,
F,

G,
J,
K
41315804
850.1400
72­
4(
a)
Fish
Early
Life­
Stage
Fathead
Minnow
(
estuarine/
marine)
A,
B,
C,
E,
F,

G,
J,
K
45119711
850.1350
72­
4(
b)
Aquatic
Invertebrate
Life­
Cycle
(
freshwater)
A,
B,
C,
E,
F,

G,
J,
K
41315805
850.1500
72­
5
Freshwater
Fish
Full
Life­
Cycle
A,
B,
C,
E,
F,

G,
J,
K
45119712
850.171
72­
6
Aquatic
Organism
Accumulation
A,
B,
C,
E,
F,

G,
J,
K
00147120
850.4225
122­
1
Seed
Germ./
Seedling
Emergence
(
Tier
2)
A,
B,
C,
E,
F,

G,
J,
K
40003711,
Data
Gap
850.4400
122­
2
Aquatic
Plant
Growth
(
Tier
2)
A,
B,
C,
E,
F,

G,
J,
K
43889102,
40811802
850.4250
123­
1
Vegetative
Vigor
(
Tier
2)
A,
B,
C,
E,
F,

G,
J,
K
43889101,
40811801,
40811802Data
Gap
850.4450
124­
2
Aquatic
Field
A,
B,
C,
E,
F,

G,
J,
K
40811802,
00131628,
00131629,
00131637,
00133554,
00147114
850.3020
141­
1
Honey
Bee
Acute
Contact
LD50
A,
B,
C,
E,
F,

G,
J,
K
00131637
TOXICOLOGY
870.1100
81­
1
Acute
Oral
Toxicity­
Rat
A,
B,
C,
E,
F,

G,
J,
K
41551002,
93048016
870.1200
81­
2
Acute
Dermal
Toxicity­

Rabbit/
Rat
A,
B,
C,
E,
F,

G,
J,
K
41551003,
93048017
870.1300
81­
3
Acute
Inhalation
Toxicity­
Rat
A,
B,
C,
E,
F,

G,
J,
K
00132032,
93048018
52
870.2400
81­
4
Primary
Eye
Irritation­
Rabbit
A,
B,
C,
E,
F,

G,
J,
K
41551001,
93048019,
Accession#
252004
870.2500
81­
5
Primary
Skin
Irritation
A,
B,
C,
E,
F,

G,
J,
K
41551004,
93048020
870.2600
81­
6
Dermal
Sensitization
A,
B,
C,
E,
F,

G,
J,
K
00131607,
93048021
870.3100
82­
1(
a)
90­
Day
Feeding
­
Rodent
A,
B,
C,
E,
F,

G,
J,
K
42774401
870.3200
82­
2
21­
Day
Dermal
­
Rabbit/
Rat
A,
B,
C,
E,
F,

G,
J,
K
00131609,
93048022
870.3700a
83­
3(
a)
Developmental
Toxicity
(
Teratogenicity)
­
rat
A,
B,
C,
E,
F,

G,
J,
K
00131611,
93048023
870.3700b
83­
3(
b)
Developmental
Toxicity
(
Teratogenicity)
­
rabbit
A,
B,
C,
E,
F,

G,
J,
K
00131613,
93048024
870.3800
83­
4
2­
Generation
Reproduction
­
Rat
A,
B,
C,
E,
F,

G,
J,
K
41039505
870.4100a
83­
1
Chronic
Toxicity
­
Rat
A,
B,
C,
E,
F,

G,
J,
K
N/
A;
see
870.4300
870.4100b
83­
1
Chronic
Toxicity
­
Dog
A,
B,
C,
E,
F,

G,
J,
K
41039502
870.4200a
83­
2
Carcinogenicity
­
Rat
A,
B,
C,
E,
F,

G,
J,
K
N/
A;
see
870.4300
870.4200b
83­
2
Carcinogenicity
­
Mouse
A,
B,
C,
E,
F,

G,
J,
K
41038505,
42774401
870.4300
83­
5
Combined
Chronic/
Carcinogenicity
A,
B,
C,
E,
F,

G,
J,
K
41039503
53
870.5100
84­
2
Bacterial
Reverse
Mutation
(
Ames
Assay)
A,
B,
C,
E,
F,

G,
J,
K
00131615,
93048025
870.5300
84­
2
In
vitro
Mammalian
Cell
Gene
Mutation
A,
B,
C,
E,
F,

G,
J,
K
00151641,
93048028
870.5375
84­
2
In
vitro
Mammalian
Chromosome
Aberration
(
CHO)
A,
B,
C,
E,
F,

G,
J,
K
00151640,
93048026
870.5450
84­
2
Rodent
Dominant
Lethal
A,
B,
C,
E,
F,

G,
J,
K
00151638
870.5500
84­
2
Unscheduled
DNA
Synthesis
A,
B,
C,
E,
F,

G,
J,
K
00151639,
93048027
870.7485
85­
1
Metabolism
and
Pharmacokinetics
­
Rat
A,
B,
C,
E,
F,

G,
J,
K
43861501
870.7600
85­
3
Dermal
Absorption
 
Rat
N/
A
N/
A
ENVIRONMENTAL
FATE
835.2120
161­
1
Hydrolysis
A,
B,
C,
E,
F,

G,
J,
K
00132359,
00131617,
00131639,
00133557
835.2240
161­
2
Photodegradation
­
Water
A,
B,
C,
E,
F,

G,
J,
K
00131617
835.4100
162­
1
Aerobic
Soil
Metabolism
A,
B,
C,
E,
F,

G,
J,
K
00131619,
41002301,
00131618,
00133557,
45119701
835.4200
162­
2
Anaerobic
Soil
Metabolism
A,
B,
C,
E,
F,

G,
J,
K
00131619,
41023201,
45119701
835.4400
162­
3
Anaerobic
Aquatic
Metabolism
A,
B,
C,
E,
F,

G,
J,
K
40003712
835.4300
162­
4
Aerobic
Aquatic
Metabolism
A,
B,
C,
E,
F,

G,
J,
K
41002301,
45119702
54
835.1240
163­
1
Leaching/
Adsorption/
Desorption
A,
B,
C,
E,
F,

G,
J,
K
00131620,
00131620,
00133557,
43423703,
45119705
835.6100
164­
1
Terrestrial
Field
Dissipation
A,
B,
C,
E,
F,

G,
J,
K
00131621,
42192101,42192102,
45119705,
45119706,
00131622,

00131623,
00131624,
0013357,
00147119
835.6200
164­
2
Aquatic
Field
Dissipation
A,
B,
C,
E,
F,

G,
J,
K
41891501,
45119707,
45119708
835.6500
164­
5
Long
Term
Soil
Dissipation
A,
B,
C,
E,
F,

G,
J,
K
45119706
N/
A
165­
4
Accumulation
in
Fish
A,
B,
C,
E,
F,

G,
J,
K
00147120
N/
A
165­
5
Accumulation
 
Aquatic
Nontarget
A,
B,
C,
E,
F,

G,
J,
K
45119722
835.7100
166­
1
Ground
Water
Monitoring
A,
B,
C,
E,
F,

G,
J,
K
44746701,
44746702,
44746703,
44865101,
44865102,
44975001,

45035201,
45139101,
45139102,
45212601,
45212602,
45335301,

45335302,
45410001,
45410002,
45498201,
45212602,
45335301,

45335302,
45410001,
45410002,
45498201,
45498202,
45663801,

45663802,
45677401
840.1100
201­
1
Spray
Droplet
Size
Spectrum
A,
B,
C,
E,
F,

G,
J,
K
41516301
840.2100
202­
1
Spray
Drift
Field
Deposition
A,
B,
C,
E,
F,

G,
J,
K
41516301
55
RESIDUE
CHEMISTRY
860.1300
171­
4(
a)
Nature
of
Residue
in
Plants
A,
B,
C,
E,
F,

G,
J,
K
45119715
860.1300
171­
4(
b)
Nature
of
Residue
in
Livestock
A,
B,
C,
E,
F,

G,
J,
K
45119716
860.1340
171­
4(
c)
Residue
Analytical
Method
­

plant
A,
B,
C,
E,
F,

G,
J,
K
45119718
860.1340
171­
4(
d)
Residue
Analytical
Method
­

livestock
A,
B,
C,
E,
F,

G,
J,
K
45119718
860.1340
171­
4(
d)
Residue
Analytical
Method
 

Water/
fish
A,
B,
C,
E,
F,

G,
J,
K
Data
Gap
860.1360
171­
4(
m)
Multiple
Residue
Methods
N/
A
N/
A
860.1380
171­
4(
e)
Storage
Stability
Data
A,
B,
C,
E,
F,

G,
J,
K
45119719,
Data
Gap
860.1400
171­
4(
h)
Fish,
water,
&
irrigated
crops
A,
B,
C,
G,
J,
K
45119709,
45119722,
4519707,
Data
Gap
860.1480
171­
4(
j)
Milk,
Meat,
Poultry,
&
Eggs
A,
B,
C,
E,
F,

G,
J,
K
45119721
860.1500
171­
4(
k)
Cropfield
Residue
(
Grass,

Forage,
&
Hay)
A,
B,
C,
E,
F,

G,
J,
K
45119720,
Data
Gap
860.1520
171­
4(
l)
Processed
Food/
Feed
N/
A
N/
A
56
860.1650
171­
13
Submittal
of
Analytical
Reference
Standards
A,
B,
C,
E,
F,

G,
J,
K
Submitted
to
EPA
National
Pesticide
Standards
Repository
860.1850
165­
1
Confined
rotational
crops
A,
B,
C,
E,
F,

G,
J,
K
45119717
860.1900
165­
2
Field
rotational
crops
A,
B,
C,
E,
F,

G,
J,
K
45119717
HED
concludes
that
there
are
no
outstanding
residue
chemistry
data
requirements
that
would
preclude
the
reassessment
of
tolerance
levels
for
reregistration
purposes,
provided
that:

 
the
registrant
submits
an
acceptable
fish
metabolism
study,

 
the
registrant
submits
adequate
corn
or
grass
storage
stability
information,

 
the
registrant
specifies
the
identity
and
quantity
of
spray
additives
used
in
all
of
the
grass
field
trials,

 
the
analytical
enforcement
method
is
determined
to
be
adequate,
and
 
labels
are
revised
to
prohibit
use
of
treated
waters
on
irrigated
crops
for
120
days
after
treatment
or
residue
data
is
provided
for
irrigated
crops.

A
few
data
gaps
were
identified
for
imazapyr
in
a
few
different
use
areas
that
include:

 
applying
sprayers
to
aquatic
sites
via
helicopters
(
PHED
data
for
fixed
wind
aerial
spray
applications
were
used
as
a
reasonable
surrogate);
and
 
mixing/
loading/
applying
liquids
to
trees
via
injection
equipment
(
no
surrogate
data
are
available
at
this
time).

For
all
agricultural
postapplication
exposure
scenarios,
data
gaps
exist
such
as
a
lack
of
imazapyr
specific
postapplication
studies.
57
Appendix
C.
Technical
Support
Documents
Additional
documentation
in
support
of
this
RED
is
maintained
in
the
OPP
Regulatory
Public
Docket
(
7502P),
Environmental
Protection
Agency,
Rm.
S­
4400,
One
Potomac
Yard
(
South
Building),
2777
S.
Crystal
Drive,
Arlington,
VA.
It
is
open
Monday
through
Friday,
excluding
legal
holidays,
from
8:
30
a.
m.
to
4:
00
p.
m.

All
documents,
in
hard
copy
form,
may
be
viewed
in
the
OPP
docket
room
or
downloaded
or
viewed
via
the
Internet
at
the
following
site:

http://
docket.
epa.
gov/
edkpub/
index.
jsp
These
documents
include:

1.
Federal
Register
Notice:
Imazapyr
Reregistration
Eligibility
Decision;
Notice
of
Availability
2.
Reader's
Guide
to
the
Imazapyr
EDOCKET
OPP­
2005­
495
3.
Imazapyr
Reregistration
Eligibility
Decision
4.
Imazapyr:
Chronic
Dietary
Exposure
Assessment
for
the
Section
3
Registration
Action
on
Grasses
and
Aquatic
Sites,
PC
Code:
128821,
DP
Barcode
D288806
(
March
26,
2003).

5.
Imazapyr:
Revised
Health
Effects
Division
(
HED)
Chapter
of
the
Reregistration
Eligibility
Document
(
RED),
PC
Code:
128821,
CAS
Reg
81334­
34­
1,
Case
#
3078,
DP
Barcode
D324106
(
December
8,
2005).

6.
Imazapyr:
Occupational
and
Residential
Exposure
Assessment
for
the
Reregistration
Eligibility
Decision
Document,
PC
Code:
128821,
DP
Barcode
D320582,
(
August
31,
2005).

7.
Response
to
Error
Only
Comments
on
the
EFED
Ecological
Risk
Assessment
Supporting
the
RED
for
the
Herbicide,
Imazapyr,
PC
Code:
128821,
DP
Barcodes:
324101,
324103,
(
December
9,
2005).

8.
Imazapyr:
Summary
of
Product
Chemistry
Data
for
Reregistration
Eligibility
Decision
(
RED)
Document,
PC
Code:
128821,
DP
Barcode:
D320579
(
August
29,
2005).

9.
Level
I
Screening
Ecological
Risk
Assessment
for
the
Reregistration
of
Imazapyr,
CAS
Number:
81334­
34­
1.
58
Appendix
D.
CITATIONS
CONSIDERED
TO
BE
PART
OF
THE
DATA
BASE
SUPPORTING
THE
REREGISTRATION
DECISION
(
BIBLIOGRAPHY)

GUIDE
TO
APPENDIX
D
1.
CONTENTS
OF
BIBLIOGRAPHY.
This
bibliography
contains
citations
of
all
studies
considered
relevant
by
EPA
in
arriving
at
the
positions
and
conclusions
stated
elsewhere
in
the
Reregistration
Eligibility
Document.
Primary
sources
for
studies
in
this
bibliography
have
been
the
body
of
data
submitted
to
EPA
and
its
predecessor
agencies
in
support
of
past
regulatory
decisions.
Selections
from
other
sources
including
the
published
literature,
in
those
instances
where
they
have
been
considered,
are
included.

2.
UNITS
OF
ENTRY.
The
unit
of
entry
in
this
bibliography
is
called
a
"
study."
In
the
case
of
published
materials,
this
corresponds
closely
to
an
article.
In
the
case
of
unpublished
materials
submitted
to
the
Agency,
the
Agency
has
sought
to
identify
documents
at
a
level
parallel
to
the
published
article
from
within
the
typically
larger
volumes
in
which
they
were
submitted.
The
resulting
"
studies"
generally
have
a
distinct
title
(
or
at
least
a
single
subject),
can
stand
alone
for
purposes
of
review
and
can
be
described
with
a
conventional
bibliographic
citation.
The
Agency
has
also
attempted
to
unite
basic
documents
and
commentaries
upon
them,
treating
them
as
a
single
study.

3.
IDENTIFICATION
OF
ENTRIES.
The
entries
in
this
bibliography
are
sorted
numerically
by
Master
Record
Identifier,
or
"
MRID"
number.
This
number
is
unique
to
the
citation,
and
should
be
used
whenever
a
specific
reference
is
required.
It
is
not
related
to
the
six­
digit
"
Accession
Number"
which
has
been
used
to
identify
volumes
of
submitted
studies
(
see
paragraph
4(
d)(
4)
below
for
further
explanation).
In
a
few
cases,
entries
added
to
the
bibliography
late
in
the
review
may
be
preceded
by
a
nine
character
temporary
identifier.
These
entries
are
listed
after
all
MRID
entries.
This
temporary
identifying
number
is
also
to
be
used
whenever
specific
reference
is
needed.

4.
FORM
OF
ENTRY.
In
addition
to
the
Master
Record
Identifier
(
MRID),
each
entry
consists
of
a
citation
containing
standard
elements
followed,
in
the
case
of
material
submitted
to
EPA,
by
a
description
of
the
earliest
known
submission.
Bibliographic
conventions
used
reflect
the
standard
of
the
American
National
Standards
Institute
(
ANSI),
expanded
to
provide
for
certain
special
needs.

a
Author.
Whenever
the
author
could
confidently
be
identified,
the
Agency
has
chosen
to
show
a
personal
author.
When
no
individual
was
identified,
the
Agency
has
shown
an
identifiable
laboratory
or
testing
facility
as
the
author.
When
no
author
or
laboratory
could
be
identified,
the
Agency
has
shown
the
first
submitter
as
the
author.

b.
Document
date.
The
date
of
the
study
is
taken
directly
from
the
document.
When
the
date
is
followed
by
a
question
mark,
the
bibliographer
has
deduced
the
date
from
the
evidence
contained
in
the
document.
When
the
date
appears
as
(
1999),
the
Agency
was
unable
to
determine
or
estimate
the
date
of
the
document.
59
c.
Title.
In
some
cases,
it
has
been
necessary
for
the
Agency
bibliographers
to
create
or
enhance
a
document
title.
Any
such
editorial
insertions
are
contained
between
square
brackets.

d.
Trailing
parentheses.
For
studies
submitted
to
the
Agency
in
the
past,
the
trailing
parentheses
include
(
in
addition
to
any
self­
explanatory
text)
the
following
elements
describing
the
earliest
known
submission:

(
1)
Submission
date.
The
date
of
the
earliest
known
submission
appears
immediately
following
the
word
"
received."

(
2)
Administrative
number.
The
next
element
immediately
following
the
word
"
under"
is
the
registration
number,
experimental
use
permit
number,
petition
number,
or
other
administrative
number
associated
with
the
earliest
known
submission.

(
3)
Submitter.
The
third
element
is
the
submitter.
When
authorship
is
defaulted
to
the
submitter,
this
element
is
omitted.

(
4)
Volume
Identification
(
Accession
Numbers).
The
final
element
in
the
trailing
parentheses
identifies
the
EPA
accession
number
of
the
volume
in
which
the
original
submission
of
the
study
appears.
The
six­
digit
accession
number
follows
the
symbol
"
CDL,"
which
stands
for
"
Company
Data
Library."
This
accession
number
is
in
turn
followed
by
an
alphabetic
suffix
which
shows
the
relative
position
of
the
study
within
the
volume.
60
Bibliography
MRID
Citation
Reference
131607
Ledoux,
T.
(
1983)
Evaluation
of
the
Sensitization
Potential
of
AC
243,997
in
Guinea
Pigs:
T.
P.
S.
Study
No.
186A­
201­

231­
83;
Spon­
sor
Study
No.
981­
83­
129.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
prepared
by
Toxicology
Pathology
Services,
Inc.,
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251503­
A)

131609
Larson,
D.;
Kelly,
W.
(
1983)
Twenty­
one
Day
Dermal
Toxicity
Study
with
AC
243,997
in
Rabbits:
T.
P.
S.
Study
No.

186B­
301­
230­
83;
Sponsor
I.
D.
No.
981­
83­
127.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
prepared
by
Toxicology
Pathology
Services,
Inc.,
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251503­
C)

131611
Salamon,
C.;
Enloe,
P.;
Mayhew,
D.;
et
al.
(
1983)
Teratology
Study
in
Albino
Rats
with
AC
243,997:
Toxigenics'
Study
450­
1222.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
prepared
by
Toxigenics,
Inc.,
submitted
by
American
Cyanamid
Co.,
Prince­
ton,
NJ;
CDL:
251504­
A)

131612
Salamon,
C.;
Enloe,
P.;
Taylor,
G.;
et
al.
(
1983)
Teratology
Pilot
Study
in
Albino
Rats
with
AC
243,997:
Toxigenics'

Study
450­
1221.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
prepared
by
Toxigenics,
Inc.,
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251504­
B)

131613
Salamon,
C.;
Enloe,
P.;
Becker,
S.;
et
al.
(
1983)
Teratology
Study
in
Albino
Rabbits
with
AC
243,997:
Toxigenics'
Study
450­
1224.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
prepared
by
Toxigenics,
Inc.,
submitted
by
American
Cyanamid
Co.,
Prince­
ton,
NJ;
CDL:
251504­
C)

131614
Salamon,
C.;
Enloe,
P.;
Becker,
S.;
et
al.
(
1983)
Teratology
Pilot
Study
in
Albino
Rabbits
with
AC
243,997:
Toxigenics'

Study
450­
1223.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
prepared
by
Toxigenics,
Inc.,
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251504­
D)

131615
Allen,
J.;
Fine,
B.;
Johnson,
E.;
et
al.
(
1983)
Bacterial/
Microsome
Reverse
Mutation
(
Ames)
Test
on
CL
243,997:
Project
No.
0493;
GTOX
5:
1­
23.
Final
rept.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251504­
E)

131616
Mallipudi,
N.;
Stout,
S.;
Stanley­
Millner,
P.;
et
al.
(
1983)
Herbi­
cide
AC
243,997:
The
Absorption,
Excretion,
Tissue
Residues
and
Metabolism
of
Carboxyl
Carbon­
14
Labeled
AC
243,997
...
in
the
Rat:
Report
No.
PD­
M
Volume
20­
13:
1­

83.
(
Unpublished
study
re­
ceived
Oct
6,
1983
under
241­
273;
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;

CDL:
251504­
F)
61
131617
Mallipudi,
M.;
Knoll,
B.;
Bullock,
M.;
et
al.
(
1983)
Arsenal
Herbi­
cide
(
AC
243,997):
Photolysis
of
Carbon­
14
Labeled
AC
243,997
?
Nicotinic
Acid,
2­(
4­
Isopropyl­
4­
methyl­
5­
oxo­
2­
imidazolin­
2­
yl)­|
in
Aqueous
Media:
Report
No.
PD­
M
Volume
20­
20.
(
Unpub­
lished
study
received
Oct
6,
1983
under
241­
273;
submitted
by
American
Cyanamid
Co.,

Princeton,
NJ;
CDL:
251505­
B)

131618
Mallipudi,
M.;
DaCunha,
A.;
Stanley­
Millner,
P.;
et
al.
(
1983)
Arsenal
Herbicide
(
AC
243,997):
Aerobic
Soil
Metabolism
of
Car­
boxyl
Carbon­
14
Labeled
AC
243,997
...
in
Sandy
Loam
Soil:
Report
No.
PDM
Volume
20­
17.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
submitted
by
American
Cyanamid
Co.,
Prince­
ton,
NJ;
CDL:
251505­
C)

131619
Mallipudi,
N.;
Knoll,
B.;
Stout,
S.;
et
al.
(
1983)
Arsenal
Herbi­
cide
(
AC
243,997):
Anaerobic
Soil
Metabolism
of
Carboxyl
Carbon­
14
Labeled
AC
243,997
...
in
Sandy
Loam
Soil:
Report
No.
PD­
M
Volume
20­
15.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251505­
D)

131620
Mallipudi,
M.;
Hewel,
D.;
Knoll,
B.;
et
al.
(
1983)
Arsenal
Herbi­
cide
(
AC
243,997):
Adsorption
and
Desorption
Coefficients
for
Soils:
Report
No.
PD­
M
Volume
20­
18.
(
Unpublished
study
re­
ceived
Oct
6,
1983
under
241­
273;

submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251505­
E)

131621
Mallipudi,
M.;
Knoll,
B.;
Stanley­
Miller,
P.
(
1983)
Arsenal
Herbi­
cide
(
AC
243,997):
Field
Dissipation
of
Carboxyl
Carbon­
14
La­
beled
AC
243,997
...:
Report
No.
PD­
M
Volume
20­
19.
(
Unpub­
lished
study
received
Oct
6,
1983
under
241­
273;
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251505­
F)

131622
Picard,
G.;
Tafuro,
A.;
Elenewski,
C.;
et
al.
(
1982)
CL
243,997:
Residues
of
CL
243,997
in
Soil
(
Post;
NY,
1981)
(
C­

2026):
Report
No.
C­
2030.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251505­
G)

131623
Elenewski,
C.;
Tafuro,
A.;
Cornelius,
A.
(
1983)
CL
243,997:
Resi­
dues
of
CL
243,997
in
Soil
(
Post;
MO,
1981)
(
C­

2026):
Report
No.
C­
2029.1.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251505­
H)

131624
Picard,
G.;
Orwick,
P.
(
1981)
CL
243,997:
Residues
of
CL
243,997
in
Soil
(
PRE;
NJ
1980)
(
C­
1819):
Report
No.
C­

1880.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;

CDL:
251505­
I)

131625
Picard,
G.;
Orwick,
P.;
Robert,
W.
(
1981)
CL
243,997:
Residues
of
CL
243,997
in
Soil
(
PRE;
MI,
1980)(
C­
1819):
Report
No.
C­
1878.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
submitted
by
American
Cyanamid
Co.,
Princeton,

NJ;
CDL:
251505­
J)
62
131626
Picard,
G.
(
1981)
CL
243,997:
Validation
of
GC
Method
M­
1131
for
the
Determination
of
CL
243,997
Residues
in
Soil:

Report
No.
C­
1819.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
submitted
by
American
Cyanamid
Co.,

Princeton,
NJ;
CDL:
251505­
K)

131627
Picard,
G.;
Elenewski,
C.
(
1982)
CL
243,997:
Validation
of
GC
Method
M­
1205
for
the
Determination
of
CL
243,997
Residues
in
Soil:
Report
No.
C­
2026.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
submitted
by
American
Cyanamid
Co.,
Prince­
ton,
NJ;
CDL:
251505­
L)

131628
American
Cyanamid
Co.
(
1983)
Summary:
Fish
and
Wildlife
Data:
AC
243,997.
(
Compilation;
unpublished
study
received
Oct
6,
1983
under
241­
273;
CDL:
251506­
A)

131629
Kintner,
D.;
Forbis,
A.
(
1983)
Acute
Toxicity
of
AC
243,997
to
Rainbow
Trout
(
Salmo
gairdneri):
Static
Bioassay
Report
#
30095.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
prepared
by
Analytical
Bio­
Chemistry
Laboratories,

Inc.,
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251506­
B)

131630
Kintner,
D.;
Forbis,
A.
(
1983)
Acute
Toxicity
of
AC
243,997
to
Bluegill
Sunfish
(
Lepomis
macrochirus):
Static
Bioassay
Report
#
30096.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
prepared
by
Analytical
Bio­
Chemistry
Laboratories,
Inc.,
submit­
ted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251506­
C)

131631
Forbis,
A.;
Kintner,
D.
(
1983)
Acute
Toxicity
of
AC
243,997
to
Channel
Catfish
(
Ictalurus
punctatus):
Static
Bioassay
Report
30097.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
prepared
by
Analytical
Bio­
Chemistry
Laboratories,
Inc.,
submit­
ted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251506­
D)

131632
Kintner,
D.;
Forbis,
A.
(
1983)
Acute
Toxicity
of
AC
243,997
to
Daphnia
magna:
Static
Acute
Bioassay
Report
#
30098.

(
Unpub­
lished
study
received
Oct
6,
1983
under
241­
273;
prepared
by
Analytical
Bio­
Chemistry
Laboratories,
Inc.,

submitted
by
Ameri­
can
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251506­
E)

131633
Fletcher,
D.
(
1983)
Report
to
...:
Acute
Oral
Toxicity
Study
with
AC
243,997
in
Bobwhite
Quail:
BLAL
No.
83
QD
20;

AC
No.
981­
83­
116.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
prepared
by
Bio­
Life
Assoc.,
Ltd.,

submitted
by
American
Cyana­
mid
Co.,
Princeton,
NJ;
CDL:
251506­
F)

131634
Fletcher,
D.
(
1983)
Report
to
...:
Acute
Oral
Toxicity
Study
with
AC
243,997
in
Mallard
Ducks:
BLAL
No.
83
DD
16;

AC
No.
981­
83­
115.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
prepared
by
Bio­
Life
Assoc.,
Ltd.,

submitted
by
American
Cyana­
mid
Co.,
Princeton,
NJ;
CDL:
251506­
G)
63
131635
Fletcher,
D.
(
1983)
Report
to
...:
8­
Day
Dietary
LC50
Study
with
AC
243,997
in
Bobwhite
Quail:
BLAL
No.
83
QC
23;

AC
No.
981­
83­
114.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
prepared
by
Bio­
Life
Assoc.,
Ltd.,

submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251506­
H)

131636
Fletcher,
D.
(
1983)
Report
to
...:
8­
Day
Dietary
LC50
Study
with
AC
243,997
in
Mallard
Ducklings:
BLAL
No.
83
DC
23;
AC
No.
981­
83­
113.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
prepared
by
Bio­
Life
Assoc.,
Ltd.,

submitted
by
American
Cyana­
mid
Co.,
Princeton,
NJ;
CDL:
251506­
I)

131637
Atkins,
E.
(
1983)
Letter
sent
to
T.
Peoples
dated
Apr
16,
1983
?
Honeybee
toxicity
study
with
AC
243,997|.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
prepared
by
Univ.
of
Cali­
fornia­­
Riverside,
Dept.
of
Entomology,
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251506­
J)

131638
Atlas,
R.
(
1983)
Assessment
of
the
Effects
of
the
Herbicide
AC
243,997
on
Soil
Microorganisms.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
prepared
by
Univ.
of
Louisville,
Dept.
of
Biology,
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251506­
K)

131639
Reichert,
B.;
Stanley­
Millner,
P.
(
1983)
Herbicide
AC
243,997:
De­
termination
of
the
Partition
Coefficient
in
n­

Octanol/
Water:
Report
No.
PD­
M
Volume
20­
10.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251506­
L)

132028
American
Cyanamid
Co.
(
1983)
Product
Chemistry:
(
AC
243,997
and
Arsenal
Herbicide).
(
Compilation;
unpublished
study
received
Oct
6,
1983
under
241­
273;
CDL:
251500­
A)

132029
American
Cyanamid
Co.
(
19??)
Summary:
Toxicology
Data:
(
AC
243,997).
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
CDL:
251502­
A)

132030
Fischer,
J.
(
1983)
Toxicity
Data
Report:
(
2­(
4­
Isopropyl­
4­
methyl­
5­
oxo­
2­
imidazolin­
2­
yl)
Nicotinic
Acid:
Rats
and
Rabbits):
Report
No.
A83­
24.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251502­
B)

132031
Fischer,
J.
(
1983)
Toxicity
Data
Report:
(
Isopropylamine
Salt
of
2­
(
4­
isopropyl­
4­
methyl­
5­
oxo­
2­
imadazolin­
2­
yl)

Nicotinic
Acid:
Rats
and
Rabbits):
Report
No.
A83­
30.
(
Unpublished
study
re­
ceived
Oct
6,
1983
under
241­
273;

submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251502­
C)

132032
Voss,
K.;
Houghtaling,
B.;
Becci,
P.
(
1983)
Acute
Inhalation
Toxi­
city
of
AC
243,997
in
Sprague­
Dawley
Rats:
FDRL
Study
No.
7624.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
prepared
by
Food
&
Drug
Research
Laboratories,
Inc.,
submitted
by
Ameri­
can
Cyanamid
Co.,
Princeton,
NJ;
CDL:
251502­
D)
64
132359
Hussain,
M.;
Mallipudi,
M.
(
1982)
CL
243,997
Herbicide:
The
Hydrol­
ysis
of
Carbon­
14
Labeled
CL
243,997:
Report
No.
PD­
M
19­
8.
(
Unpublished
study
received
Oct
6,
1983
under
241­
273;
submitted
by
American
Cyanamid
Co.,

Princeton,
NJ;
CDL:
251505­
A)

133546
American
Cyanamid
Co.
(
1983)
Toxicology
Data:
(
AC243,997
&
Others).
(
Unpublished
study
received
Dec
15,
1983
under
241­
EX­
101;
CDL:
252004­
A)

133547
Ledoux,
T.
(
1983)
Evaluation
of
the
Sensitization
Potential
of
AC
243,997
in
Guinea
Pigs:
T.
P.
S.
Study
No.
186A­
201­

231­
83;
Spon­
sor
Study
No.
981­
83­
129.
(
Unpublished
study
received
Dec
15,
1983
under
241­
EX­
101;
prepared
by
Toxicology
Pathology
Ser­
vices,
Inc.,
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
252004­
F)

133549
Kintner,
D.;
Forbis,
A.
(
1983)
Acute
Toxicity
of
AC
243,997
to
Bluegill
Sunfish
(
Lepomis
macrochirus):
Static
Bioassay
Report
#
30096.
(
Unpublished
study
received
Dec
15,
1983
under
241­
EX­
101;
prepared
by
Analytical
Bio­
Chemistry
Laboratories,
Inc.,
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
252004­
I)

133550
Kintner,
D.;
Forbis,
A.
(
1983)
Acute
Toxicity
of
AC
243,997
to
Daphnia
magna:
Static
Bioassay
Report
#
30098.

(
Unpublished
study
received
Dec
15,
1983
under
241­
EX­
101;
prepared
by
An­
alytical
Bio­
Chemistry
Laboratories,
Inc.,

submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
252004­
K)

133551
Fletcher,
D.
(
1983)
Report
to
...:
Acute
Oral
Toxicity
Study
with
AC
243,997
in
Mallard
Ducks:
AC
No.
981­
83­
115;

BLAL
No.
83
DD
16.
(
Unpublished
study
received
Dec
15,
1983
under
241­
EX­
101;
prepared
by
Bio­
Life
Assoc.,
Ltd.,

submitted
by
American
Cyan­
amid
Co.,
Princeton,
NJ;
CDL:
252004­
L)

133552
Fletcher,
D.
(
1983)
Report
to
...:
8­
Day
Dietary
LC50
Study
with
AC
243,997
in
Bobwhite
Quail:
BLAL
No.
83
QC
23;

AC
No.
981­
83­
114.
(
Unpublished
study
received
Dec
15,
1983
under
241­
EX­
101;
prepared
by
Bio­
Life
Assoc.,
Ltd.,

submitted
by
American
Cyan­
amid
Co.,
Princeton,
NJ;
CDL:
252004­
M)

133553
Fletcher,
D.
(
1983)
Report
to
...:
8­
Day
Dietary
LC50
Study
with
AC
243,997
in
Mallard
Ducklings:
BLAL
No.
83
DC
23;
AC
No.
981­
83­
113.
(
Unpublished
study
received
Dec
15,
1983
under
241­
EX­
101;
prepared
by
Bio­
Life
Assoc.,

Ltd.,
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
252004­
N)

133554
Atkins,
E.;
Kellum
(
1983)
Bee
Adult
Toxicity
Dusting
Test
Summary:
Test
No.
389.
(
Unpublished
study
received
Dec
15,
1983
under
241­
EX­
101;
prepared
by
Univ.
of
California­­
Riverside,
Dept.
of
Entomology,
submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
252004­
O)

133555
Reichert,
B.;
Stanley­
Miller,
P.
(
1983)
Herbicide
AC
243,997:
De­
termination
of
the
Partition
Coefficient
in
n­

Octanol/
Water:
Report
No.
PD­
M
Volume
20­
10.
(
Unpublished
study
received
Dec
15,
1983
under
241­
EX­
101;

submitted
by
American
Cyanamid
Co.,
Princeton,
NJ;
CDL:
252004­
P)
65
133556
American
Cyanamid
Co.
(
1983)
Product
Chemistry:
(
AC
243,997
and
Others).
(
Compilation;
unpublished
study
received
Dec
15,
1983
under
241­
EX­
101;
CDL:
252005­
A)

133557
American
Cyanamid
Co.
(
1983)
Residue
and
Environmental
Fate:(
Arsen­
al
Herbicide
(
AC
243,997
&
Others).

(
Compilation;
unpublished
study
received
Dec
15,
1983
under
241­
EX­
101;
CDL:
252006­
A)

145872
American
Cyanamid
Co.
(
19??)
Product
Chemistry
­­
Technical
Materi­
al
[
Arsenal
Herbicide].
Unpublished
compilation.
163
p.

147049
Fischer,
J.
(
1984)
Summary
of
Experimental
Results:
(
Acute
Toxicity:
Arsenal
Technical):
Report
No.
A84­
52.

Unpublished
study
prepared
by
American
Cyanamid
Co.
5
p.

147114
American
Cyanamid
Co.
(
1985?)
Summary:
Fish
and
Wildlife­­
Addition­
al
Data
for
Full
Registration
of
Arsenal
Herbicide
for
Noncrop
Uses.
Unpublished
study.
2
p.

147118
American
Cyanamid
Co.
(
1985?)
Summary:
Environmental
Fate­­
Addi­
tional
Data
for
Full
Registration
of
Arsenal
Herbicide
for
Non­
crop
Uses.
Unpublished
study.
4
p.

147119
Mallipudi,
N.
(
1985)
Arsenal
Herbicide,
AC
243,997:
Weed
and
Soil
Metabolism
in
a
Field
Plot:
Report
No.
PD­
M
Volume
22­
23:
1­
89.
Unpublished
study
prepared
by
American
Cyanamid
Co.
89
p.

147120
McAllister,
W.;
Bunch,
B.;
Burnett,
J.
(
1985)
Bioconcentration
and
Depuration
of
[
Radiolabeled
Carbon]­
AC
243,
997
by
Bluegill
Sun­
fish
...
under
Flow­
through
Conditions:
ABC
Final
Report
#
32819.
Unpublished
study
prepared
by
Analytical
Bio­
Chemistry
Laborato­
ries,
Inc.
259
p.

147121
American
Cyanamid
Co.
(
1985)
Product
Chemistry:
Additional
Data
for
Full
Registration
of
Arsenal
Herbicide
for
Noncrop
Uses.
Unpub­
lished
compilation.
105
p.

151637
American
Cyanamid
Co.
(
1985?)
Toxicology:
Summary
and
Sample
Iden­
tification
and
Purity:
[
Mutagenicity].

Unpublished
study.
8
p.

151638
Enloe,
P.;
Pfiffner,
A.;
Salamon,
C.
(
1985)
Dominant
Lethal
Assay
in
Male
Rats
with
AC
243,997:
Toxigenics'
Study
450­
1284:
[
In­
cludes
Pilot
Study
No.
450­
1283
by
Toxigenics,
Inc.].
Unpub­
lished
study
prepared
by
Toxigenics,
Inc.

212
p.

151639
Sernau,
R.
(
1984)
Unscheduled
DNA
Synthesis
Rat
Hepatocyte
Assay:
Compound
AC
243,997:
Final
Report:
Project
No.
362­
170.
Unpub­
lished
study
prepared
by
Hazleton
Laboratories
America,
Inc.
18
p.
66
151640
Cortina,
T.
(
1984)
In
vitro
Chromosomal
Aberrations
in
Chinese
Ham­
ster
Ovary
Cells
with
AC­
243,997:
Final
Report:

362­
169.
Unpub­
lished
study
prepared
by
Hazleton
Laboratories
America,
Inc.
34
p.

151641
Johnson,
E.;
Allen,
J.
(
1984)
Mutagenicity
Testing
of
AC
243,997
in
the
in
vitro
CHO/
HGPRT
Mutation
Assay:
Project
No.
0493.
Unpub­
lished
study
prepared
by
American
Cyanamid
Co.
39
p.

163194
American
Cyanamid
Co.
(
1986)
Chopper
Herbicide:
Product
Chemistry.
Unpublished
compilation.
45
p.

163195
Fischer,
J.
(
1986)
Toxicity
Data
Report:
[
Summary
of
Experimental
Results]:
Chopper
C/
A
Formulation:
Report
No.

A86­
31.
Unpub­
lished
summaries
prepared
by
American
Cyanamid
Co.
5
p.

163196
Hershman,
R.
(
1986)
Acute
Inhalation
Toxicity
­
Rats:
Chopper
Herbicide:
Project
No.
86­
5095A.
Unpublished
study
prepared
by
Biosearch
Inc.
24
p.

163197
Sahota,
P.
(
1986)
Dermal
Sensitization
Study
with
Chopper
Herbicide
in
Guinea
Pigs:
DRC
4901.
Unpublished
study
prepared
by
Dawson
Research
Corp.
25
p.

40070900
American
Cyanamid
Co.
(
1987)
Registration
for
Contain
Herbicide:
Acute
Toxicology.
Compilation
of
1
Study.

40070901
Fisher,
J.
(
1986)
Contain
Acute
Toxicology
of
Herbicide:
Laboratory
Report
No.:
A
86­
28.
Unpublished
compilation
prepared
by
Ameri­
can
Cyanamid
Co.
10
p.

40387200
American
Cyanamid
Co.
(
1987)
Submission
of
Chemistry
Data
to
Sup­
port
the
Registration
for
Arsenal
5­
G
Herbicide
for
Noncrop
and
Forestry
Usage.
Transmittal
of
2
studies.

40387201
Beardmore,
R.
(
1987)
Product
Identity
and
Disclosure
of
Ingredien­
ts:
Arsenal
5­
G.
Unpublished
study
prepared
by
American
Cyana­
mid
Co.
15
p.

40387202
Beardmore,
R.
(
1987)
Physical
Chemical
Properties
of
Arsenal
5­
G.
Unpublished
study
prepared
by
American
Cyanamid
Co.
4
p.

40403700
American
Cyanamid
Co.
(
1987)
Submission
of
Residue
Data
Petition
for
Exemption
from
a
Food
Additive
Tolerance
for
Imazapyr
in
or
on
Palm
Oil.
Transmittal
of
3
studies.

40403701
Mallipudi,
N.
(
1987)
Imazapyr
Herbicide
(
AC
243,
997):
Metabolism
of
Carbon­
14
Imazapyr
[
Nicotinic
acid,
2­(
4­

isopropyl­
4­
methyl­
5­
oxo­
2­
yl­]
in
Oil
Palm:
Laboratory
Report
No.
PD­
M
Volume
23­
38.
Unpublished
study
prepared
by
American
Cyanamid
Co.
54
p.
67
40403702
Potts,
C.
(
1987)
Arsenal
Herbicide
(
CL
243,997/
IPAS­
AS):
Residues
of
CL
243,997
in
Palm
Oil
Fruit
...:
Laboratory
Report
No.:
C­
2461.
Unpublished
study
prepared
by
American
Cyanamid
Co.
12
p.

40403703
Potts,
C.
(
1987)
Arsenal
Herbicide
(
CL
252,925):
GC
Method
for
the
Determination
of
CL
243,997
Residues
in
Oil
Palm
Fruit:
Labora­
tory
Report
No.
C­
2422.
Unpublished
study
prepared
by
American
Cyanamid
Co.
13
p.

40421600
American
Cyanamid
Co.
(
1987)
Submission
of
Residue
Data
To
Support
the
Application
for
the
Registration
of
Imazapyr.
Transmittal
of
1
study.

40421601
Mangels,
G.
(
1987)
Imazapyr
Herbicide
(
AC
243,997):
Metabolism
of
Carbon­
14
Imazapyr
?
Nicotinic
Acid,
2­(
4­

isopropyl­
4­
methyl­
5­
oxo­
2­
yl)­|
in
Sugarcane:
Laboratory
Report
No.
PD­
M
Volume
24­
19.
Unpublished
study
prepared
by
American
Cyanamid
Co.
27
p.

40672700
American
Cyanamid
Co.
(
1988)
Product
Chemistry
Data
submitted
for
Arsenal
Herbicide
0.5G
Registration:
?
Minor
Amendments|.
Trans­
mittal
of
1
study.

40672701
Garber,
M.
(
1988)
Amendments
to
the
Disclosure
of
Ingredients
...
and
Certification
of
Limits:
Arsenal
Herbicide
0.5G.

Unpub­
lished
study
prepared
by
American
Cyanamid
Co.
7
p.

40763400
American
Cyanamid
Co.
(
1988)
Submission
of
Product
Chemistry
and
Toxicity
Data
to
Support
the
Registration
for
Event.
Transmit­
tal
of
2
studies.

40763401
American
Cyanamid
Co.
(
1988)
Product
Identity
and
Disclosure
of
Ingredients:
Event.
Unpublished
study.
21
p.

40763402
Lowe,
C.
(
1988)
Acute
Oral,
Acute
Dermal,
Eye
Irritation,
and
Skin
Irritation
Studies
with
Event
Formulation:
Rept.
No.

A87­
3.
Unpublished
study
prepared
by
American
Cyanamid
Co.
8
p.

40811800
American
Cyanamid
Co.
(
1988)
Submission
of
Environmental
Data
in
Support
of
Partial
Fulfillment
of
the
Unconditional
Registration
of
Imazapyr
in
Forestry.
Transmittal
of
2
studies.

40811801
American
Cyanamid
Co.
(
1988)
The
Effect
of
Arsenal
on
Non­
target
Terrestrial
Plants:
Tier
II.
Unpublished
compilation.

172
p.

40811802
Hughes,
J.
(
1987)
The
Effect
of
Arsenal
on
Non­
target
Aquatic
Plants:
Tier
II:
Laboratory
Project
ID:
0214­
67­
1100­

1,2,3,4.
Unpublished
compilation
prepared
by
Malcolm
Pirnie,
Inc.
180
p.

41002300
American
Cyanamid
Co.
(
1989)
Submission
of
Data
To
Support
Regi­
stration
of
Imazapyr:
Environmental
Fate
Study.

Transmittal
of
1
study.
68
41002301
American
Cyanamid
Co.
(
1988)
Imazapyr
(
AC243,997):
Aerobic
Aquatic
Degradation:
Report
No.
PD­
M
Volume
25­
51.

Unpublished
study.
33
p.

41023200
American
Cyanamid
Co.
(
1989)
Submission
of
Data
To
Support
Regi­
stration
of
Arsenal
Herbicide:
Soil
Metabolism
Data.
Transmit­
tal
of
1
study.

41023201
Tollackson,
L.
(
1988)
Aerobic
Soil
Metabolism
of
?
carbon
13|­?
car­
bon
14|­
AC
243,997
in
Sandy
Loam
Soil
at
1.5
ppm
Concentration
at
25
degrees
C:
Report
No.
34927.
Unpublished
study
prepared
by
ABC
Laboratories,
Inc.
561
p.

41039500
America
Cyanamid
Co.
(
1989)
Submission
of
Data
To
Support
Registra­
tion
of
Imazapyr
(
Arsenal
Technical):

Toxicology
Data.
Trans­
mittal
of
5
studies.

41039501
Harris,
J.
(
1989)
Imazapyr
Toxicology
Summary.
Unpublished
study
prepared
by
American
Cyanamid
Co.
9
p.

41039502
Shellenberger,
T.
(
1987)
One
Year
Dietary
Toxicity
Study
in
Pure­
bred
Beagle
Dogs
with
AC
243,997:
Report
No.

86002.
Unpublished
study
prepared
by
Tegeris
Laboratories,
Inc.
685
p.

41039503
Daly,
I.
(
1988)
A
Chronic
Dietary
Toxicity
and
Oncogenicity
Study
with
AC
243,997
in
Rats:
Report
No.
84­
2862.

Unpublished
study
prepared
by
Bio/
dynamics
Inc.
3597
p.

41039504
Auletta,
C.
(
1988)
A
Chronic
Dietary
Toxicity
and
Oncogenicity
Study
with
AC
243,997
in
Mice:
Report
No.
86­
3074.

Unpublished
study
prepared
by
Bio/
dynamics
Inc.
2795
p.

41039505
Robinson,
K.
(
1987)
A
2­
Generation
(
2­
Litter)
Reproduction
Study
of
AC
243,997
Administered
in
the
Diet
of
the
Rat:

Report
No.
82408.
Unpublished
study
prepared
by
Bio­
Research
Laboratories
Ltd.
1194
p.

41315800
American
Cyanamid
Co.
(
1989)
Submission
of
studies
in
support
of
reregistration
for
Arsenal
(
Imazapyr):
Aquatic
organism
toxi­
city.
Transmittal
of
5
studies.

41315801
Manning,
C.
(
1989)
Acute
Toxicity
of
AC
243,997
to
Atlantic
Silversides
(
Menidia
menidia):
Final
Report:
Lab
Report
No.
87384­
0300­
2130;
AC
243,997/
MM;
Protocol
971­
87­
153.
Unpub­
lished
study
prepared
by
Environmental
Science
and
Engineering,
Inc.
(
ESE).
33
p.

41315802
Ward,
C.
(
1989)
Acute
Toxicity
on
New
Shell
Growth
of
the
Eastern
Oyster
(
Crassostrea
virginica):
Final
Report:
Lab
Report
No.
87384­
0400­
2130;
AC
243,997/
OYS;
Protocol
971­
87­
151.
Unpublished
study
prepared
by
Environmental
Science
and
Engineering,
Inc.
(
ESE).
36
p.
69
41315803
Manning,
G.
(
1989)
Acute
Toxicity
of
AC
243,997
to
Pink
Shrimp
(
Penaeus
duoraram):
Final
Report:
Lab
Report
No.

87384­
0200­
2130;
AC
243,997/
PS;
Protocol
971­
87­
152.
Unpublished
study
prepared
by
Environmental
Science
and
Engineering,
Inc.
(
ESE).
33
p.

41315804
Manning,
C.
(
1989)
Chronic
Toxicity
Estimate
of
AC
243,997
to
Rainbow
Trout
(
Salmo
gairdneri)
under
Flow
through
Conditions:
Final
Report:
Lab
Report
No.
87384­
0600­
2130;
AC
243,997/
RT;
Protocol
971­
87­
155.
Unpublished
study
prepared
by
Environ­
mental
Science
and
Engineering,
Inc.
(
ESE).
45
p.

41315805
Manning,
C.
(
1989)
Chronic
Effect
of
AC
243,997
to
the
Water
Flea
(
Daphnia
magna)
in
a
21­
day
Flow­
through
Exposure:
Final
Report:
Lab
Report
No.
87384­
0500­
2130;
AC
243,997/
DM;
Protocol
020F.
Unpublished
study
prepared
by
Environmental
Science
and
Engineering,
Inc.
(
ESE).
44
p.

41353400
American
Cyanamid
Co.
(
1990)
Submission
of
Chemistry
and
Toxicity
Data
in
Support
of
Chopper
RTU
Herbicide
Registration.
Trans­
mittal
of
9
studies.

41353401
American
Cyanamid
Co.
(
1989)
Product
Identity
and
Disclosure
Ingredients:
?
Imazapyr|.
Unpublished
study.
15
p.

41353402
Banick,
W.
(
1989)
Certification
of
Limits
and
Analytical
Method:
?
Imazapyr|.
Unpublished
study
prepared
by
American
Cyanamid
Co.
22
p.

41353403
Peevey,
R.
(
1989)
Physical
and
Chemical
Properties
of
Chopper
RTU
Herbicide.
Unpublished
study
prepared
by
American
Cyanamid
Co.
8
p.

41353404
Fischer,
J.
(
1989)
Oral
LD50
Study
in
Albino
Rats
with
AC
243,997
6%
RTU
Formulation:
Lab
Project
Number:
T­
0186:

Report
No.
A89­
205.
Unpublished
study
prepared
by
American
Cyanamid
Co.
14
p.

41353405
Fischer,
J.
(
1989)
Dermal
LD50
Study
in
Albino
Rabbits
with
AC
243,997
6%
RTU
Formulation:
Lab
Project
Number:

T­
0187:
Report
No.
A89­
203.
Unpublished
study
prepared
by
American
Cyanamid
Co
14
p.

41353406
Fischer,
J.
(
1989)
Eye
Irritation
Study
in
Albino
Rabbits
with
AC
243,997
6%
RTU
Formulation:
Lab
Project
Number:
T­

0182:
Report
No.
A89­
200.
Unpublished
study
prepared
by
American
Cyanamid
Co.
15
p.

41353407
Fischer,
J.
(
1989)
Skin
Irritation
Study
in
Albino
Rabbits
with
AC
243,997
6%
RTU
Formulation:
Lab
Project
Number:

T­
0184:
Report
No.
A89­
201.
Unpublished
study
prepared
by
American
Cyanamid
Co.
15
p.

41353408
Werley,
M.
(
1987)
Final
Report
on
a
Single
Point
Inhalation
Expo­
sure
to
Chopper
RTU­
6
in
Adult
Sprague­
Dawley
Rats
of
Both
Sexes:
Lab
Project
Number:
MB
87­
8931
E.
Unpublished
study
prepared
by
MB
Research
Laboratories,
Inc.

55
p.
70
41353409
American
Cyanamid
Co.
(
1988)
Dermal
Sensitization
in
Guinea
Pigs:
Lab
Project
Number:
MB
87­
8931
F.
Unpublished
study
prepared
by
MB
Research
Laboratories,
Inc.
13
p.

41516300
American
Cyanamid
Co.
(
1990)
Submission
of
Efficacy
Study
to
Sup­
port
the
Registration
of
Imazapyr.
Transmittal
of
1
study.

41516301
Iverson,
R.
(
1990)
Discussion
and
Summary
of
Reference
Articles
on
Helicopter
Spray
Drift.
Unpublished
study
prepared
by
American
Cyanamid
Co.
41
p.

41664700
American
Cyanamid
Co.
(
1990)
Submission
of
Product
Chemistry
Data
to
Support
the
Reregistration
of
ARSENAL.

Transmittal
of
1
Study.

41664701
Cortes,
D.
(
1990)
Phase
3
Summary
of
MRID
#
145872:
Imazapyr­
Phy­
sical
and
Chemical
Characteristics
Solubility
in
Water
and
in
Solvents:
Lab
Project
Number:
PD/
M/
27/
36.
Unpublished
study
prepared
by
American
Cyanamid
Co.
56
p.

41891500
American
Cyanamid
Co.
(
1991)
Submission
of
environmental
fate
data
to
support
an
application
for
nonfood
use
of
Arsenal
herbicide.
Transmittal
of
1
study.

41891501
American
Cyanamid
Co.
(
1991)
Aquatic
Dissipation
Studies
and
Rela­
ted
Data
?
Arsenal
Herbicide|:
Lab
Project
Number:
CY
41.
328
p.
Unpublished
study.
328
p.

42062400
American
Cyanamid
Co.
(
1991)
Submission
of
toxicity
data
to
support
the
registration
standard
for
Imazapyr
(
Arsenal).

Transmittal
of
1
study.

42062401
Daly,
I.;
Harris,
J.;
Koeferl,
M.
(
1991)
A
Chronic
Dietary
Toxicity
and
Oncogenicity
Study
with
AC
243,
997
in
Rats
(
Historical
Con­
trol
Data):
Supplement
to
MRID
41039503:
Lab
Project
Number:
84­
2862.
Unpublished
study
prepared
by
Bio/
Dynamics
Inc.
139
p.

42087300
American
Cyanamid
Co.
(
1991)
Submission
of
product
chemistry
data
to
support
the
reregistration
standard
for
Imazapyr.

Transmittal
of
1
study.

42087301
Cortes,
D.
(
1991)
Imazapyr
Storage
Stability
and
Corrosion
Characteristics.
Unpublished
study
prepared
by
American
Cyanamid
Co.
27
p.

42165400
American
Cyanamid
Co.
(
1992)
Submission
of
product
chemistry
and
toxicity
data
in
support
of
registration
of
Arsenal
(
R)/
Diuron
Granule.
Transmittal
of
9
studies.

42165401
Little,
D.
(
1991)
Product
Identity
and
Disclosure
of
Ingred­
ients,
Arsenal/
Diuron
Granule.
Unpublished
study
prepared
by
American
Cyanamid
Co.
15
p.
71
42165402
Wu,
H.
(
1991)
Analysis
and
Certification
of
Limits,
Arsenal/
Diuron
Granules.
Unpublished
study
prepared
by
American
Cyanamid
Co.
48
p.

42165403
Kimler,
J.
(
1991)
Physical
and
Chemical
Characterisitics,
Arsenal/
Diuron
Granule.
Unpublished
study
prepared
by
American
Cyananmid
Co.
42
p.

42165404
Lowe,
C.
(
1991)
Oral
LD50
Study
in
Albino
Rats
with
AC
243,
997/
AC
58,901
(
0.5%/
2%)
Granular
Formulation:
Lab
Project
Number:
STUDY
T­
0363.
Unpublished
study
prepared
by
American
Cyanamid
Co.
14
p.

42165405
Lowe,
C.
(
1991)
Dermal
LD50
Study
in
Albino
Rabbits
with
AC
243,
997/
AC
58,901
(
0.5%/
2%)
Granular
Formulation:

Lab
Project
Number:
STUDY
T­
0366.
Unpublished
study
prepared
by
American
Cyanamid
Co.
14
p.

42165406
Hershman,
R.
(
1991)
Acute
Inhalation
Toxicity
Study
with
Imazapyr/
Diuron
in
Rats:
Lab
Project
Number:
91­
7249A.

Unpublished
study
prepared
by
Biosearch
Inc.
45
p.

42165407
Lowe,
C.
(
1991)
Eye
Irritation
Study
in
Albino
Rabbits
with
AC
243,997/
AC
58,901
(
0.5%/
2%)
Granular
Formulation:

Lab
Project
Number:
STUDY
T­
0350.
Unpublished
study
prepared
by
American
Cyanamid
Co.
15
p.

42165408
Lowe,
C.
(
1991)
Skin
Irritation
Study
in
Albino
Rabbits
with
AC
243,997/
AC
58,901
(
0.5%/
2%)
Granular
Formulation:

Lab
Project
Number:
STUDY
T­
0352.
Unpublished
study
prepared
by
American
Cyanamid
Co.
14
p.

42165409
Lowe,
C.
(
1991)
Skin
Sensitization
Study
in
Albino
Guinea
Pigs
with
AC
243,997/
AC
58,901
(
0.5%/
2%)
Granular
Formulation:
Lab
Project
Number:
STUDY
T­
0415.
Unpublished
study
prepared
by
American
Cyanamid
Co.
27
p.

42774401
Hess,
F.
(
1992)
Additional
Data
on
Chronic
Toxicology
Studies
(
Rodent),
New
Subchronic
Rodent
Study,
and
Rationale
Supporting
the
Acceptability
of
the
Chronic
Rodent
Study:
(
including
AC
243,997:
A
13­
week
Dietary
Toxicity
Study
in
the
Albino
Rat:
Am.
Cyanamid
Lab
report
AX­
92­
3).
Unpublished
study
prepared
by
American
Cyanamid
Co.
547
p.

43423700
American
Cyanamid
Co.
(
1994)
Submission
of
Product
Chemistry
and
Environmental
Fate
Data
in
Support
of
Arsenal
Reregistration.
Transmittal
of
3
Studies.

43423701
Cortes,
D.;
Chiarello,
G.
(
1994)
Product
Identity,
Description
of
Beginning
Materials
and
Manufacturing
Process,
and
Theoretical
Discussion
of
Impurities
of
ARSENAL
Herbicide
Technical:
Lab
Project
Number:
APBR
386:
CHDV­
30­

4.1.
Unpublished
study
prepared
by
American
Cyanamid
Co.
56
p.

43423702
Danishevsky,
V.;
Cortes,
D.
(
1994)
Preliminary
Analysis,
Certification
of
Ingredient
Limits,
and
Analytical
Method
for
ARSENAL
Herbicide
Technical:
Lab
Project
Number:
APBR
362:
APBR
386.
Unpublished
study
prepared
by
American
Cyanamid
Co.
200
p.
72
43423703
Mangels,
G.
(
1994)
AC
243,997
Adsorption/
Desorption:
Lab
Project
Number:
ENV
94­
022.
Unpublished
study
prepared
by
American
Cyanamid
Co.
41
p.

43578000
American
Cyanamid
Co.
(
1995)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Arsenal/
Diuron
70
DG
Herbicide.
Transmittal
of
9
Studies.

43578001
Wixson,
M.
(
1995)
Product
Identification
and
Disclosure
of
Ingredients,
Description
of
Beginning
Materials
and
Manufacturing
Process,
Discussion
of
Formation
of
Impurities:
Arsenal/
Diuron
70
DG
Herbicide.
Unpublished
study
prepared
by
American
Cyanamid
Co.
15
p.

43578002
Owtscharuk,
P.;
Banick,
W.
(
1995)
Certification
of
Limits
and
Analytical
Methods:
Arsenal/
Diuron
70
DG
Herbicide:

Lab
Project
Numbers:
C­
4109:
94FAI­
0493­
02.
Unpublished
study
prepared
by
American
Cyanamid
Co.
49
p.

43578003
Arendt,
V.
(
1994)
Physical
and
Chemical
Characteristics:
Arsenal/
Diuron
70
DG
Herbicide:
Lab
Project
Numbers:
F­

1291:
94PIF­
0493­
06.
Unpublished
study
prepared
by
American
Cyanamid
Co.
18
p.

43578004
Lowe,
C.
(
1994)
Oral
LD50
in
Albino
Rats
with
AC
243,997/
AC
58,901:
70
DG
Formulation:
Lab
Project
Numbers:
T­

0702:
A94­
239.
Unpublished
study
prepared
by
American
Cyanamid
Co.
16
p.

43578005
Lowe,
C.
(
1994)
Dermal
LD50
in
Albino
Rats
with
AC
243,997/
AC
58,901:
70
DG
Formulation:
Lab
Project
Numbers:

T­
0703:
A94­
240.
Unpublished
study
prepared
by
American
Cyanamid
Co.
15
p.

43578006
Hoffman,
G.
(
1995)
Acute
Inhalation
Study
with
AC
243,997/
AC
58,901:
70
DG
Formulation
in
Rats:
Lab
Project
Numbers:
94­
5178:
971­
94­
101:
TAN
94­
044.
Unpublished
study
prepared
by
Pharmco
LSR.
109
p.

43578007
Boczon,
L.
(
1994)
Eye
Irritation
Study
in
Albino
Rats
(
sic)
with
AC
243,997/
AC
58,901:
70
DG
Formulation:
Lab
Project
Numbers:
T­
0700:
A94­
246:
P94­
1044.
Unpublished
study
prepared
by
American
Cyanamid
Co.
15
p.

43578008
Boczon,
L.
(
1994)
Skin
Irritation
Study
in
Albino
Rabbits
with
AC
243,997/
AC
58,901:
70
DG
Formulation:
Lab
Project
Numbers:
T­
0701:
A94­
243:
P94­
1045.
Unpublished
study
prepared
by
American
Cyanamid
Co.
16
p.

43578009
Boczon,
L.
(
1994)
Dermal
Sensitization
Study
in
Albino
Guinea
Pigs
with
AC
243,997/
AC
58,901:
70
DG
Formulation
Using
the
Buehler
Closed
Patch
Method:
Lab
Project
Numbers:
T­
0707:
A94­
249:
P94­
1056.
Unpublished
study
prepared
by
American
Cyanamid
Co.
27
p.

43831400
American
Cyanamid
Co.
(
1995)
Submission
of
Hazard
to
Wildlife
Data
in
Support
of
the
Reregistration
of
Arsenal
Herbicide.
Transmittal
of
2
Studies.
73
43831401
Fletcher,
D.;
Pedersen,
C.;
Solatycki,
A.;
et
al.
(
1995)
Toxicity
and
Reproduction
Study:
AC
243,997
Technical:

Bobwhite
Quail
(
Colinus
virginianus):
Revised
Final
Report:
Lab
Project
Number:
991­
86­
124:
86
QR
16:
OREP
856.01.

Unpublished
study
prepared
by
Bio­
Life
Associates,
Inc.
379
p.

43831402
Fletcher,
D.;
Pedersen,
C.;
Solatycki,
A.;
et
al.
(
1995)
Toxicity
and
Reproduction
Study:
Mallard
Duck
(
Anas
platyrhynchos):
AC
243,997
Technical:
Revised
Final
Report:
Lab
Project
Number:
991­
86­
123:
86
DR
15:
OREP
856.01.
Unpublished
study
prepared
by
Bio­
Life
Associates,
Inc.
398
p.

43861500
American
Cyanamid
Co.
(
1995)
Submission
of
Product
Chemistry,
Toxicology,
Metabolism
and
Residue
Chemistry
Data
in
Support
of
the
Registration
of
AC
513,996
Herbicide
and
the
Petition
for
Tolerance
for
Imazapyr
on
Field
Corn.

Transmittal
of
18
Studies.

43861501
Mallipudi,
N.;
Wu,
D.
(
1994)
CL
243,997:
Rat
Metabolism
Study:
Lab
Project
Number:
RPT0074:
MET
94­
009:

XBL90045.
Unpublished
study
prepared
by
Xenobiotic
Labs,
Inc.
and
Hazleton
Wisconsin,
Inc.
520
p.

43861502
Zulalian,
J.
(
1995)
Imazapyr
(
CL
243,997):
Metabolism
of
Carbon­
14
Labeled
CL
243,997
Using
Radishes,
Soybeans,

Lettuce
and
Winter
Wheat
as
Rotational
Crops:
Lab
Project
Number:
MET
95­
003:
M93P997NC2:
0462.
Unpublished
study
prepared
by
American
Cyanamid
Co.
216
p.

43861503
Zulalian,
J.
(
1995)
CL
243,997:
Metabolism
of
Carbon­
14
Labeled
CL
243,997
in
Imidazolinone­
Resistant
Corn
Under
Field
Conditions:
Lab
Project
Number:
MET
95­
002:
M93P997NC1:
0462.
Unpublished
study
prepared
by
American
Agricultural
Services,
Inc.
347
p.

43861504
Zdybak,
J.
(
1992)
CL
243,997:
Carbon­
14
Labeled
CL
243,997­
Derived
Residues
in
Blood,
Milk
and
Edible
Tissues
of
Lactating
Goats:
Lab
Project
Number:
PD­
M
29­
34:
RPT0025:
89020.
Unpublished
study
prepared
by
Xenobiotic
Labs,

Inc.
and
Biological
Test
Center.
126
p.

43861505
Tsalta,
C.
(
1995)
CL
243,997:
Metabolic
Fate
of
(
carbon
14)­
CL
243,997
in
Tissues
and
Eggs
of
the
Laying
Hen:
Lab
Project
Number:
MET
95­
007:
M94A997PT1.
Unpublished
study
prepared
by
American
Cyanamid
Co.
170
p.

43861506
Frazier,
T.;
Krueger,
R.
(
1995)
Product
Identification
and
Disclosure
of
Ingredients,
Decription
of
Beginning
Materials
and
Manufacturing
Process,
Discussion
of
Formation
of
Impurities:
(
AC
513,996
Herbicide).
Unpublished
study
prepared
by
American
Cyanamid
Co.
15
p.

43861507
Fletcher,
J.
(
1995)
CL
243,997:
Independent
Laboratory
Validation
of
GC/
MS
Method
M
2468
for
the
Determination
of
CL
243,997
Residues
in
Corn
Grain,
Forage
and
Fodder:
Lab
Project
Number:
RES
95­
080:
M­
2468:
AR94PT02.

Unpublished
study
prepared
by
Centre
Analytical
Labs,
Inc.
68
p.
74
43861508
Piznik,
M.
(
1995)
Certification
of
Limits
and
Analytical
Methods:
(
AC
513,996):
Lab
Project
Number:
F­
1325:
95FAI­

0193­
01.
Unpublished
study
prepared
by
American
Cyanamid
Co.
48
p.

43861509
Ong,
J.
(
1995)
Imazethapyr/
Imazapyr
70
DG
Herbicide:
Physical
and
Chemical
Characteristics:
Lab
Project
Number:
F­

1341:
95PIF­
0193­
09.
Unpublished
study
prepared
by
American
Cyanamid
Co.
22
p.

43861510
Lowe,
C.
(
1995)
Oral
LD50
Study
in
Albino
Rats
with
AC
263,499/
AC
243,997
70DG
Formulation:
Lab
Project
Number:
T­
0805:
A95­
151.
Unpublished
study
prepared
by
American
Cyanamid
Co.
18
p.

43861511
Lowe,
C.
(
1995)
Dermal
LD50
Study
in
Albino
Rats
with
AC
263,499/
AC
243,997
70DG
Formulation:
Lab
Project
Number:
T­
0806:
A95­
152.
Unpublished
study
prepared
by
American
Cyanamid
Co.
18
p.

43861512
Hoffman,
G.
(
1995)
Acute
Inhalation
Toxicity
Study
with
AC
263,499/
AC
243,997
70DG
in
Rats:
Lab
Project
Number:

94­
5221.
Unpublished
study
prepared
by
Pharmaco
LSR.
90
p.

43861513
Boczon,
L.
(
1995)
Eye
Irritation
Study
in
Albino
Rabbits
with
AC
263,499/
AC
243,997
70
DG
Formulation:
Lab
Project
Number:
T­
0792:
A95­
127.
Unpublished
study
prepared
by
American
Cyanamid
Co.
17
p.

43861514
Boczon,
L.
(
1995)
Skin
Irritation
Study
in
Albino
Rabbits
with
AC
263,499/
AC
243,
997
70
DG
Formulation:
Lab
Project
Number:
T­
0790:
A95­
128.
Unpublished
study
prepared
by
American
Cyanamid
Co.
15
p.

43861515
Boczon,
L.
(
1995)
Dermal
Sensitization
Study
in
Albino
Guinea
Pigs
with
AC
263,499/
AC
243,997
70
DG
Formulation
Using
the
Buehler
Closed
Patch
Method:
Lab
Project
Number:
A95­
111.
01:
T­
0796.
Unpublished
study
prepared
by
American
Cyanamid
Co.
30
p.

43861516
Fletcher,
J.;
Khunachak,
A.
(
1995)
CL
243,997:
Extractability
and
Accountability
of
CL
243,997
Residues
in
Corn
Grain
and
Plant:
Lab
Project
Number:
RES
95­
081:
AR95PT01.
Unpublished
study
prepared
by
American
Cyanamid
Co.
34
p.

43861517
Fletcher,
J.;
Zheng,
S.
(
1995)
CL
243,997:
Freezer
Storage
Stability
of
Residues
of
CL
243,997
in
Corn
Commodities
(
Grain,
Forage,
and
Fodder):
Lab
Project
Number:
RES
95­
163:
AR94PT01:
007­
35.
Unpublished
study
prepared
by
Centre
Analytical
Labs,
Inc.
52
p.

43861518
Mahl,
T.
(
1995)
CL
243,997
(
Imazapyr):
Crop
Residue
Study
with
AC
243,997
on
Field
Corn:
Lab
Project
Nos.:
RES
95­

083;
RES
95­
085;
RES
95­
086.
Unpublished
study
prepared
by
Agsearch
Co.;
Centre
Analytical
Labs,
Inc.;
and
Agvise
Labs.
1702
p.

44027100
American
Cyanamid
Co.
(
1996)
Submission
of
Toxicology
Data
in
Support
of
the
Application
for
Registration
of
AC
513,996.
Transmittal
of
1
Study.
75
44027101
Boczon,
L.;
Fischer,
J.
(
1995)
Eye
Irritation
Study
in
Albino
Rabbits
with
AC
263,499/
AC
243,997
70
DG
Formulation:

Addendum
to
MRID
43861513:
Lab
Project
Number:
T­
0792:
A95­
127.
Unpublished
study
prepared
by
American
Cyanamid
Co.
4
p.

44034500
American
Cyanamid
Co.
(
1996)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Registration
Application
for
AC
513,995
Herbicide.
Transmittal
of
9
Studies.

44034501
Frazier,
T.
(
1996)
Product
Identification
and
Disclosure
of
Ingredients,
Description
of
Beginning
Materials
and
Manufacturing
Process,
Discussion
of
Formation
of
Impurities:
AC
513,995
Herbicide.
Unpublished
study
prepared
by
American
Cyanamid
Co.
17
p.

44034502
Owtscharuk,
P.
(
1996)
Certification
of
Limits
and
Analytical
Methods:
AC
513,995
Herbicide:
Lab
Project
Number:

F1353.
Unpublished
study
prepared
by
American
Cyanamid
Co.
63
p.

44034503
Ong,
J.
(
1996)
Imazethapyr/
Imazapyr/
Dicamba
DG
Herbicide:
Physical
and
Chemical
Characteristics:
Lab
Project
Number:
F­
1357:
0193:
95PIF­
0193­
13.
Unpublished
study
prepared
by
American
Cyanamid
Co.
21
p.

44034504
Lowe,
C.
(
1996)
Oral
LD50
Study
in
Albino
Rats
with
CL
263,499/
CL
243,997/
CL
350,410
DG
Formulation:
Lab
Project
Number:
T­
0865:
A95­
220.
Unpublished
study
prepared
by
American
Cyanamid
Co.
26
p.

44034505
Lowe,
C.
(
1996)
Dermal
LD50
Study
in
Albino
Rats
with
CL
263,499/
CL
243,997/
CL
350,410
DG
Formulation:
Lab
Project
Number:
T­
0864:
A95­
219.
Unpublished
study
prepared
by
American
Cyanamid
Co.
20
p.

44034506
Hoffman,
G.
(
1996)
Acute
Inhalation
Toxicity
Study
with
CL
263,499/
CL
243,997/
CL
350,410
DG
in
Rats:
Lab
Project
Number:
95/
5248:
TAN/
95/
034:
971/
95/
114.
Unpublished
study
prepared
by
Huntingdon
Life
Sciences.
80
p.

44034507
Boczon,
L.
(
1996)
Eye
Irritation
Study
in
Albino
Rabbits
with
CL
263,499/
CL
243,997/
CL
350,410
DG
Formulation:

Lab
Project
Number:
T/
0860:
A95/
200.
Unpublished
study
prepared
by
American
Cyanamid
Co.
17
p.

44034508
Boczon,
L.
(
1996)
Skin
Irritation
Study
in
Albino
Rabbits
with
CL
263,499/
CL
243,997/
CL
350,410
DG
Formulation:

Lab
Project
Number:
T/
0861:
A95/
199.
Unpublished
study
prepared
by
American
Cyanamid
Co.
16
p.

44034509
Glaza,
S.
(
1996)
Dermal
Sensitization
Study
with
CL
263,499/
CL
243,997/
CL
350,410
DG
in
Guinea
Pigs:
Lab
Project
Number:
CHW/
50802096:
971/
95/
141:
50802096.
Unpublished
study
prepared
by
Corning
Hazleton
Inc.
64
p.

44081900
American
Cyanamid
Co.
(
1996)
Submission
of
Residue
Data
in
Support
of
the
Application
for
Registration
of
AC
513,996
Herbicide
and
the
Petition
for
Tolerance
of
Imazapyr
on
Corn.
Transmittal
of
1
Study.
76
44081901
Fletcher,
J.;
Zheng,
S.;
Zulalian,
J.
et
al.
(
1996)
CL
243,997:
Freezer
Stability
of
Residues
of
CL
243,997
in
Corn
Commodities
(
Grain,
Forage
and
Fodder):
Addendum:
Lab
Project
Number:
RES
95­
163:
MET
95­
002.01:
AR94PT01.

Unpublished
study
prepared
by
Centre
Analytical
Labs.,
Inc.
8
p.

44087700
American
Cyanamid
Co.
(
1996)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Arsenal
75
SG
Herbicide.
Transmittal
of
9
Studies.

44087701
Birk,
J.
(
1995)
Arsenal
75
SG
Herbicide:
Product
Identity
and
Composition.
Unpublished
study
prepared
by
American
Cyanamid
Co.
15
p.

44087702
Piznik,
M.
(
1996)
Arsenal
75
SG
Herbicide:
Certification
of
Limits
and
Analytical
Methods:
(
Amended
Report):
Lab
Project
Number:
F­
1299:
M­
1504.02:
94­
FAI­
0493­
08.
Unpublished
study
prepared
by
American
Cyanamid
Co.
53
p.

44087703
Arendt,
V.;
Comisky,
S.
(
1995)
Arsenal
75
SG
Herbicide:
Physical
and
Chemical
Characteristics:
Lab
Project
Number:
F­

1296:
94PIF­
0493­
14:
0493.
Unpublished
study
prepared
by
American
Cyanamid
Co.
18
p.

44087704
Lowe,
C.;
Bradley,
D.
(
1996)
Oral
LD50
Study
in
Albino
Rats
with
AC
243,997
75
SG
Formulation:
(
Arsenal
75
SG):

Lab
Project
Number:
A95­
88.01:
T­
0763.
Unpublished
study
prepared
by
American
Cyanamid
Co.
19
p.

44087705
Lowe,
C.
(
1995)
Dermal
LD50
Study
in
Albino
Rats
with
AC
243,997
75
SG
Formulation:
(
Arsenal
75
SG):
Lab
Project
Number:
T­
0769:
A95­
91.
Unpublished
study
prepared
by
American
Cyanamid
Co.
18
p.

44087706
Hoffman,
G.
(
1995)
Acute
Inhalation
Study
with
AC
243,997
75
SG
in
Rats:
(
Arsenal
75
SG):
Lab
Project
Number:
94­

5211:
971­
94­
124:
TAN
95­
005.
Unpublished
study
prepared
by
Pharmaco
LSR,
Inc.
116
p.

44087707
Boczon,
L.
(
1995)
Eye
Irritation
Study
in
Albino
Rabbits
with
AC
243,997
75
SG
Formulation:
(
Arsenal
75
SG):
Lab
Project
Number:
A95­
81:
T­
0766.
Unpublished
study
prepared
by
American
Cyanamid
Co.
15
p.

44087708
Boczon,
L.
(
1995)
Skin
Irritation
Study
in
Albino
Rabbits
with
AC
243,997
75
SG
Formulation:
(
Arsenal
75
SG):
Lab
Project
Number:
T­
0767:
A95­
80.
Unpublished
study
prepared
by
American
Cyanamid
Co.
15
p.

44087709
Boczon,
L.
(
1995)
Dermal
Sensitization
Study
in
Albino
Guinea
Pigs
with
AC
243,997
75
SG
Formulation
(
Arsenal
75
SG)
Using
the
Buehler
Closed
Patched
Method:
Lab
Project
Number:
T­
0775:
A95­
93.
Unpublished
study
prepared
by
American
Cyanamid
Co.
27
p.

44102800
American
Cyanamid
Co.
(
1996)
Submission
of
Residue
Data
in
Support
of
the
Registration
and
Petition
for
AC
513996
Herbicide
(
Imazapyr)
Use
in
Corn.
Transmittal
of
1
Study.
77
44102801
Fletcher,
J.
(
1996)
CL
243,997:
Independent
Laboratory
Validation
of
CE
Method
M
2657
for
the
Determination
of
CL
243,997
Residues
in
Corn
Grain,
Forage
and
Fodder:
Lab
Project
Number:
AR96PT01:
RES96­
074:
007­
85.
Unpublished
study
prepared
by
Centre
Analytical
Labs.,
Inc.
69
p.

44272200
American
Cyanamid
Co.
(
1997)
Submission
of
Residue
Data
in
Support
of
the
Registration
of
Lightning
Herbicide
and
Tolerance
Petition
for
Imazapyr
in/
on
Corn.
Transmittal
of
1
Study.

44272201
Fletcher,
J.;
Picard,
J.
(
1997)
CL
243,997:
Freezer
Stability
of
Residues
of
CL
243,997
in
Corn
Commodities
(
Grain,

Forage
and
Fodder):
Final
Report:
Lab
Project
Number:
RES
97­
016:
AR94PT01:
P94­
1068.
Unpublished
study
prepared
by
Centre
Analytical
Labs.,
Inc.
56
p.

44341400
American
Cyanamid
Co.
(
1997)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Reregistration
of
Imazapyr
Containing
Product
Arsenal
Railroad
Herbicide.
Transmittal
of
1
Study.

44341401
Chiarello,
G.
(
1995)
Arsenal
Technical
(
AC
243997)
Grade
Active
Ingredient­­
Thermal
Stability
to
Metals
at
Elevated
Temperatures
and
Stability
when
Exposed
to
Artificial
Sunlight:
(
Final
Report):
Lab
Project
Number:
P
141:
94­
PROC­

0196­
6:
P
139.
Unpublished
study
prepared
by
American
Cyanamid
Co.
44
p.

44626700
American
Cyanamid
Company
(
1998)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Registration
of
Lightning
Herbicide.
Transmittal
of
1
Study.

44626701
Steller,
W.
(
1998)
Discussion
of
the
Formation
of
Impurities
of
Lightning
Herbicide.
Unpublished
study
prepared
by
American
Cyanamid
Company.
7
p.
{
OPPTS
830.1670}

44630800
American
Cyanamid
Company
(
1998)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Registration
of
Arsenal
75SG
Herbicide.
Transmittal
of
1
Study.

44630801
Steller,
W.
(
1998)
Discussion
of
the
Formation
of
Impurities
of
Arsenal
75SG
Herbicide.
Unpublished
study
prepared
by
American
Cyanamid
Company.
7
p.
{
OPPTS
830.1670}

44642900
American
Cyanamid
Company
(
1998)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Registration
of
Sahara
DG
Herbicide.
Transmittal
of
1
Study.

44642901
Steller,
W.
(
1998)
Discussion
of
the
Formation
of
Impurities
of
Sahara
DG
Herbicide.
Unpublished
study
prepared
by
American
Cyanamid
Company.
7
p.
{
OPPTS
830.1670}

44735300
American
Cyanamid
Company
(
1999)
Submission
of
Toxicity
Data
in
Support
of
the
Reregistration
of
Arsenal
Herbicide
Technical.
Transmittal
of
1
Study.
78
44735301
Lowe,
C.
(
1999)
Oral
LD50
Study
in
Albino
Rats
with
AC
243997:
Lab
Project
Number:
A98­
90:
T­
1076.
Unpublished
study
prepared
by
American
Cyanamid
Company.
17
p.
{
OPPTS
870.1100}

44746700
American
Cyanamid
Company
(
1999)
Submission
of
Environmental
Fate
Data
in
Support
of
the
Registration
of
Lightning
Herbicide.
Transmittal
of
3
Studies.

44746701
Stout,
S.;
Folmar,
K.
(
1999)
CL
263499
(
Imazethapyr):
Independent
Laboratory
Validation
of
LC/
MS
Determinative
Method
M
3119
for
Residues
of
CL
263499
in
Water:
Lab
Project
Number:
RES
98­
081.
Unpublished
study
prepared
by
Centre
Analytical
Laboratories,
Inc.
60
p.

44746702
Mangels,
G.;
Brandt,
J.;
Carver,
L.
(
1999)
Site
Characterization
and
Instrumentation
Report:
A
Small­
Scale
Prospective
Ground­
Water
Monitoring
Study
for
Imazethapyr
on
Corn
in
the
Midwestern
United
States:
Lab
Project
Number:
EEA
98­
03:
EXA
99­
003.
Unpublished
study
prepared
by
Centre
Analytical
Laboratories,
Inc.
and
Agvise
Laboratories,
Inc.

138
p.

44746703
Mangels,
G.;
Erbe,
M.;
Carver,
L.
(
1999)
Site
Characterization
and
Instrumentation
Report:
A
Small­
Scale
Prospective
Ground­
Water
Monitoring
Study
for
Imazethapyr
on
Corn
in
the
Southeastern
United
States:
Lab
Project
Number:
EEA
98­
04:
EXA
99­
002.
Unpublished
study
prepared
by
Centre
Analytical
Laboratories,
Inc.
and
Agvise
Laboratories,
Inc.

142
p.

44761300
American
Cyanamid
Company
(
1999)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Liquid
Lightning
Herbicide.
Transmittal
of
9
Studies.

44761301
White,
R.
(
1998)
Product
Identification
and
Disclosure
of
Ingredients,
Description
of
Beginning
Materials
and
Manufacturing
Process,
Discussion
of
Formation
of
Impurities:
Liquid
Lightning
Herbicide.
Unpublished
study
prepared
by
American
Cyanamid
Company.
15
p.

44761302
Zeng,
M.
(
1998)
Certification
of
Limits
and
Analytical
Methods:
Liquid
Lightning
Herbicide:
Lab
Project
Number:
F­

1404.
Unpublished
study
prepared
by
American
Cyanamid
Company.
54
p.

44761303
Johnson,
J.;
Kovacs,
G.;
Sweetapple,
G.
(
1998)
Liquid
Lightning
Herbicide:
Physical
and
Chemical
Characteristics:
Lab
Project
Number:
F­
1407:
1857­
98­
0120­
AS­
001.
Unpublished
study
prepared
by
American
Cyanamid
Company
and
Analytical
Services.
5
p.

44761304
Lowe,
C.
(
1998)
Oral
LD50
Study
in
Albino
Rats
with
AC
263499/
AC
243997
1.8
AS:
Liquid
Lightning
Herbicide:
Lab
Project
Number:
A98­
60.
Unpublished
study
prepared
by
American
Cyanamid
Company.
20
p.
79
44761305
Lowe,
C.;
Bradley,
D.
(
1998)
Dermal
LD50
Study
in
Albino
Rats
with
AC
263499/
AC
243997
1.8
AS:
Liquid
Lightning
Herbicide:
Lab
Project
Number:
A98­
73.
Unpublished
study
prepared
by
American
Cyanamid
Company.
20
p.

44761306
Hoffman,
G.
(
1998)
Acute
Inhalation
Toxicology
Study
with
AC
263499/
AC
243997
1.8
AS
in
Rats:
Liquid
Lightning
Herbicide:
Lab
Project
Number:
98­
5352.
Unpublished
study
prepared
by
Huntington
Life
Sciences.
63
p.

44761307
Boczon,
L.
(
1998)
Primary
Eye
Irritation
Study
in
Albino
Rats
with
AC
263499/
AC
243997
1.8
AS:
Liquid
Lightning
Herbicide:
Lab
Project
Number:
A98­
55:
T­
1063.
Unpublished
study
prepared
by
American
Cyanamid
Company.
19
p.

44761308
Boczon,
L.
(
1998)
Primary
Dermal
Irritation
Study
in
Albino
Rats
with
AC
263499/
AC
243997
1.8
AS:
Liquid
Lightning
Herbicide:
Lab
Project
Number:
A98­
59:
T­
1064.
Unpublished
study
prepared
by
American
Cyanamid
Company.
18
p.

44761309
Blanset,
D.
(
1998)
Dermal
Sensitization
Study
with
AC
263499/
AC
243997
1.8
AS
in
Guinea
Pigs­­
Buehler
Method
(
Nine
Inductions):
Liquid
Lightning
Herbicide:
Lab
Project
Number:
98­
1792.
Unpublished
study
prepared
by
Huntington
Life
Sciences.
43
p.

44865100
American
Cyanamid
Company
(
1999)
Submission
of
Environmental
Fate
and
Residue
Chemistry
Data
in
Support
of
the
Registration
of
Lightning
Herbicide.
Transmittal
of
3
Studies.

44865101
Carver,
L.;
Johnson,
L.;
Kleiner,
A.
(
1999)
A
Small­
Scale
Prospective
Groundwater
Monitoring
Study
for
Imazethapyr
on
Corn
in
the
Southeastern
United
States:
First
Progress
Report:
Lab
Project
Number:
44657:
007­
202:
EXA­
99­
015.

Unpublished
study
prepared
by
Research
Options,
Inc.
and
ABC
Labs.
114
p.

44865102
Carver,
L.;
Johnson,
L.;
Kleiner,
A.
(
1999)
A
Small­
Scale
Prospective
Groundwater
Monitoring
Study
for
Imazethapyr
on
Corn
in
the
Midwestern
United
States:
First
Progress
Report:
Lab
Project
Number:
44656:
007­
198:
EXA­
99­
014.

Unpublished
study
prepared
by
Research
Options,
Inc.
and
ABC
Labs.
112
p.

44865103
Cavalier,
T.
(
1997)
CL
263499(
Imazethapyr):
Independent
Laboratory
Validation
of
Capillary
Electrophoresis
(
CE)

Determinative
and
LC/
MS
Confirmatory
Method
M
2683
for
the
Determination
of
CL
263499
Residues
in
Soil:
Lab
Project
Number:
RES
97­
059.
Unpublished
study
prepared
by
Centre
Analytical
Laboratories,
Inc.
112
p.

44975000
American
Cyanamid
Company
(
1999)
Submission
of
Environmental
Fate
Data
in
Support
of
the
Registration
of
Lightning
Herbicide.
Transmittal
of
1
Study.

44975001
Carver,
L.;
Johnson,
L.;
Kleiner,
A.
(
1999)
A
Small­
Scale
Prospective
Groundwater
Monitoring
Study
for
Imazethapyr
on
Corn
in
the
Southeastern
United
States
(
Georgia):
Lab
Project
Number:
44657:
007­
202:
EXA­
99­
022.
Unpublished
study
prepared
by
ABC
Labs,
Inc.,
and
Research
Options,
Inc.
161
p.
{
OPPTS
840.2100}
80
45035200
American
Cyanamid
Co.
(
1999)
Submission
of
Environmental
Fate
Data
in
Support
of
the
Registration
of
Lightning
Herbicide.
Transmittal
of
1
Study.

45035201
Pease,
C.;
Johnson,
L.;
Kleiner,
A.
(
1999)
A
Small­
Scale
Prospective
Groundwater
Monitoring
Study
for
Imazethapyr
on
Corn
in
the
Midwestern
United
States
(
Indiana):
Second
Progress
Report:
Lab
Project
Number:
44656:
007­
198:
EXA­

99­
021.
Unpublished
study
prepared
by
ABC
Labs.
and
Centre
Analytical
Labs.,
Inc.
163
p.
{
OPPTS
840.2100}

45119700
American
Cyanamid
Company
(
2000)
Submission
of
Environmental
Fate,
Residue
and
Toxicology
Data
in
Support
of
the
Petition
for
Tolerances
of
Imazapyr
for
Aquatic
Uses
and
for
Use
on
Grass.
Transmittal
of
23
Studies.

45119701
Ta,
C.
(
1999)
AC
243997:
Aerobic
Soil
Metabolism:
Lab
Project
Number:
ENV
98­
029:
E
98­
029.
Unpublished
study
prepared
by
American
Cyanamid
Company.
72
p.

45119702
Ta,
C.
(
1999)
CL
119060
and
CL
9140:
Aerobic
Aquatic
Metabolism:
Lab
Project
Number:
ENV
98­
018:
E
98­
018.

Unpublished
study
prepared
by
American
Cyanamid
Company.
158
p.

45119703
Borysewicz,
R.;
Corbett,
M.;
Duan,
B.;
et
al.
(
2000)
Methods
of
Analysis
of
Imazapyr
Residue
in
Soil
and
Pond
Water:

Lab
Project
Number:
RES
98­
047:
RES
98­
152:
RES
99­
127.
Unpublished
study
prepared
by
American
Cyanamid
Company
and
Centre
Analytical
Labs,
Inc.
255
p.

45119704
Khunachak,
A.;
Ouyang,
Z.;
Singh,
S.;
et
al.
(
1999)
Freezer
Storage
Stability
of
Imazapyr
Residue
in
Soil,
Sediment,
and
Pond
Water:
Lab
Project
Number:
RES
99­
056:
RES
99­
052:
RES
99­
053.
Unpublished
study
prepared
by
American
Cyanamid
Company
and
Centre
Analytical
Labs,
Inc.
245
p.

45119705
Holman,
J.
(
2000)
AC
243997
(
Imazapyr)
and
Metabolites:
Adsorption/
Desorption
on
Sediments:
Lab
Project
Number:

ENV
98­
025:
E­
98­
025.
Unpublished
study
prepared
by
American
Cyanamid
Company.
97
p.

45119706
Garrett,
A.
(
2000)
Rate
of
Dissipation
of
Soil
Residues
of
Imazapyr:
Lab
Project
Number:
RES
99­
108:
RES
99­
109:

AR96IA01.
Unpublished
study
prepared
by
American
Cyanamid
Company,
Centre
Analytical
Labs,
Inc.,
and
Midwest
Research,
Inc.
333
p.

45119707
Borysewicz,
R.
(
1999)
Residues
of
CL
243997,
CL
9140,
and
CL
119060
in
Aquatic
Field
Dissipation
and
Aquatic
Non­

Target
Organisms
for
Arsenal
Herbicide
Applied
to
Freshwater
Ponds:
Lab
Project
Number:
RES
99­
059:
RES
99­
060:

AR96FL01.
Unpublished
study
prepared
by
American
Cyanamid
Company,
Centre
Analytical
Labs
Inc.,
Florida
Pesticide
Research,
and
Maxim
Technologies,
Inc.
681
p.
81
45119708
Mangels,
G.;
Ritter,
A.;
Safarpour,
M.
(
2000)
Estimated
Environmental
Concentrations
of
Imazapyr
Resulting
from
Aquatic
Uses
of
Arsenal
Herbicide:
Lab
Project
Number:
EXA
00­
008.
Unpublished
study
prepared
by
American
Cyanamid
Company.
346
p.

45119709
Drottar,
K.;
Swigert,
J.;
Wisk,
J.
(
1996)
Uptake,
Depuration,
Bioconcentration,
and
Metabolism
of
(
carbon
14)
AC
243997
in
Eastern
Oyster
and
Grass
Shrimp:
Lab
Project
Number:
954­
93­
165:
ECO
93­
165.01:
954­
93­
164.

Unpublished
study
prepared
by
American
Cyanamid
Company
and
Wildlife
International
Ltd.
228
p.

45119710
Drottar,
K.;
Olivieri,
C.;
Swigert,
J.
et
al.
(
1997)
Effect
of
AC
243997
on
96­
Hour
Shell
Deposition
in
the
Eastern
Oyster
(
Crassosstrea
virginica)
Under
Flow­
Through
Test
Conditions:
Lab
Project
Number:
ECO
97­
139:
130A­
111:
197.05.

Unpublished
study
prepared
by
American
Cyanamid
Company
and
Wildlife
International
Ltd.
64
p.
{
OPPTS
850.1025}

45119711
Drottar,
K.;
Olivieri,
C.;
Swigert,
J.
et
al.
(
1998)
Toxicity
of
AC
243997
During
the
Early
Life­
Stages
of
the
Fathead
Minnow
(
Pimephales
promelas):
Lab
Project
Number:
ECO
97­
102:
954­
97­
137:
197.05.
Unpublished
study
prepared
by
American
Cyanamid
Company
and
Wildlife
International
Ltd.
154
p.
{
OPPTS
850.1400}

45119712
Drottar,
K.;
Olivieri,
C.;
Krueger,
H.
(
1999)
Toxicity
of
AC
243997
(
Imazapyr)
Technical
during
the
Full
Life­
Cycle
of
the
Fathead
Minnow
(
Pimephales
promelas)
under
Flow­
Through
Test
Conditions:
Lab
Project
Number:
ECO
97­
101:

130A­
113:
954­
97­
101.
Unpublished
study
prepared
by
American
Cyanamid
Company
and
Wildlife
International
Ltd.

176
p.
{
OPPTS
850.1500}

45119713
Drottar,
K.;
Swigert,
J.;
Wisk,
J.
(
1995)
Acute
Toxicity
of
Arsenal
Herbicide
to
the
Rainbow
Trout
(
Oncorhynchus
mykiss)
Under
Flow­
Through
Test
Condition:
Lab
Project
Number:
954­
94­
127:
130A­
107:
0199.
Unpublished
study
prepared
by
American
Cyanamid
Company
and
Wildlife
International
Ltd.
73
p.
{
OPPTS
850.1075}

45119714
Ahmed,
M.;
Kapustka,
L.;
Wisk,
J.
(
1999)
Avian
Reproduction
Studies
on
AC
243997
Technical:
Lab
Project
Number:

ECO
97­
147:
ECO
97­
146:
954­
97­
147.
Unpublished
study
prepared
by
American
Cyanamid
Company
and
Wildlife
International
Ltd.
362
p.
{
OPPTS
850.2300}

45119715
Wu,
D.
(
1997)
AC
243997:
Metabolism
in
Bermuda
Grass
Under
Field
Conditions:
Lab
Project
Number:
MET
96­
007:

RPT0084:
XBL
91041.
Unpublished
study
prepared
by
American
Cyanamid
Company,
Pan­
Agricultural
Lab
Inc.,
and
XenoBiotic
Labs
Inc.
221
p.
{
OPPTS
860.1300}

45119716
Tsalta,
C.
(
2000)
CL
243997:
Metabolism
of
(
carbon
14)­
CL
243997
in
the
Lactating
Goat:
Lab
Project
Number:
MET
00­
002:
M99A997PT1.
Unpublished
study
prepared
by
American
Cyanamid
Company.
160
p.
{
OPPTS
860.1300,

860.1340}
82
45119717
Mallipudi,
N.
(
2000)
Imazapyr
(
AC
243997):
Confined
Rotational
Crop
Study
with
(
Carbon
14)
Labled
AC
243997:
Lab
Project
Number:
MET
00­
003:
M97P997NC1:
0527.
Unpublished
study
prepared
by
American
Cyanamid
Company
and
American
Agricultural
Services,
Inc.
338
p.
{
OPPTS
860.1850}

45119718
Bixler,
T.;
Fletcher,
J.;
Gross,
J.
et
al.
(
1999)
Validations
of
Methods
of
Analysis
of
Imazapyr
Residues
in
Grass,
Cattle
Tissue
and
Milk,
Fish,
and
Shellfish:
Lab
Project
Number:
RES
99­
001:
RES98­
108:
RES
99­
002.
Unpublished
study
prepared
by
American
Cyanamid
Company,
ABC
Labs
Inc.,
and
Maxim
Tech
Inc.
422
p.
{
OPPTS
860.1340}

45119719
Bixler,
T.;
Fletcher,
J.;
Khunachak,
A.;
et
al.
(
2000)
Freezer
Storage
Stability
of
Imazapyr
Residues
in
Cattle
Tissue,

Milk,
and
Fish:
Lab
Project
Number:
RES
99­
035:
RES
99­
031:
RES
99­
064.01.
Unpublished
study
prepared
by
American
Cyanamid
Company,
ABC
Labs
Inc.,
and
Maxim
Tech
Inc.
102
p.
{
OPPTS
860.1380}

45119720
Garrett,
A.;
Baragary,
N.;
Khunachak,
A.
(
1999)
Magnitude
of
Residues
of
Imazapyr
in
Grass
after
Treatment
with
Arsenal
Herbicide:
Lab
Project
Number:
RES
98­
038:
RES
98­
039:
RES
99­
017.
Unpublished
study
prepared
by
American
Cyanamid
Company,
ABC
Labs
Inc.,
AgSearch
Company,
and
AgSolutions
Inc.
1147
p.
{
OPPTS
860.1500}

45119721
Khunachak,
A.
(
1999)
Arsenal
(
Imazapyr­
CL
243997):
Magnitude
of
CL
243997
in
Milk,
Milk
Fat
and
Edible
Tissues
from
Dairy
Cattle
After
Oral
Administration
for
at
Least
28
Days:
Lab
Project
Number:
RES
99­
100:
AR97PT07:
44390.

Unpublished
study
prepared
by
American
Cyanamid
Company,
ABC
Labs
Inc.,
Fort
Dodge
Animal
Health,
and
Maxim
Technologies.
232
p.
{
OPPTS
860.1480}

45119722
Christensen,
G.;
Madsen,
T.;
Skorczynski,
S.;
et
al.
(
1999)
Field
Accumulation
Study
of
Arsenal
Herbicide
in
Freshwater
Clam:
Lab
Project
Number:
ECO
98­
197:
44881:
954­
98­
1973.
Unpublished
study
prepared
by
American
Cyanamid
Company
and
ABC
Laboratories,
Inc.
62
p.

45119723
Lowe,
C.
(
2000)
Acute
Oral
LD50
Studies
in
Albino
Rats
with
AC
119060
and
AC
9140:
Lab
Project
Number:
T­
0255:

T­
0256:
A90­
133.01.
Unpublished
study
prepared
by
American
Cyanamid
Company.
32
p.
{
OPPTS
870.1100}

45139100
American
Cyanamid
Company
(
2000)
Submission
of
Environmental
Fate
Data
in
Support
of
the
Application
for
Registration
of
Lightning
Herbicide.
Transmittal
of
2
Studies.

45139101
Carver,
L.;
Johnson,
L.;
Kleiner,
A.
(
2000)
A
Small­
Scale
Prospective
Groundwater
Monitoring
Study
for
Imazethapyr
on
Corn
in
the
Southeastern
United
States
(
Georgia):
Fourth
Progress
Report:
Lab
Project
Number:
007­
202:
EXA­
99­

022.02:
EEA
98­
04.
Unpublished
study
prepared
by
Research
Options,
Inc.
and
ABC
Laboratories.
137
p.

45139102
Carver,
L.;
Johnson,
L.;
Kleiner,
A.
(
2000)
A
Small­
Scale
Prospective
Groundwater
Monitoring
Study
for
Imazethapyr
on
Corn
in
the
Midwestern
United
States
(
Indiana):
Fourth
Progress
Report:
Lab
Project
Number:
44656:
007­
198:
EXA­
99­

021.02.
Unpublished
study
prepared
by
AgSearch
Company
and
ABC
Laboratories.
188
p.
83
45212600
BASF
Corporation
(
2000)
Submission
of
Environmental
Fate
Data
in
Support
of
the
Registration
of
Lightning
Herbicide.

Transmittal
of
2
Studies.

45212601
Carver,
L.;
Johnson,
L.;
Kleiner,
A.
(
2000)
A
Small­
Scale
Prospective
Groundwater
Monitoring
Study
for
Imazethapyr
on
Corn
in
the
Southeastern
United
States
(
Georgia)(
Lightning
Herbicide):
Lab
Project
Number:
007­
202:
EXA­
99­
022.03.

Unpublished
study
prepared
by
Research
Options,
Inc.,
ABC
Laboratories,
and
Centre
Analytical
Laboratories,
Inc.
143
p.

{
OPPTS
840.2100}

45212602
Carver,
L.;
Johnson,
L.;
Kleiner,
A.
(
2000)
A
Small­
Scale
Prospective
Groundwater
Monitoring
Study
for
Imazethapyr
on
Corn
in
the
Midwestern
United
States
(
Indiana)(
Lightning
Herbicide):
Lab
Project
Number:
44656.
Unpublished
study
prepared
by
AgSearch
Company,
ABC
Laboratories,
and
Centre
Analytical
Laboratories,
Inc.
196
p.
{
OPPTS
840.2100}

45215100
BASF
Corporation
(
2000)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
AC
1014109
Herbicide.
Transmittal
of
9
Studies.

45215101
Arthur,
J.
(
2000)
Product
Identification
and
Disclosure
of
Ingredients,
Description
of
Beginning
Materials
and
Manufacturing
Process,
Discussion
of
Formation
of
Impurities:
AC
1014109
Herbicide.
Unpublished
study
prepared
by
BASF
Corporation.
16
p.
{
OPPTS
830.1550,
830.1600,
830.1650,
830.1670}

45215102
Arthur,
J.;
Safarpour,
H.;
Piznik,
M.
(
2000)
Certification
of
Limits
and
Analytical
Methods:
AC
1014109
Herbicide:
Lab
Project
Number:
F1445/
F1299:
99FA­
0224­
03:
0224.
Unpublished
study
prepared
by
BASF
Corporation.
99
p.
{
OPPTS
830.1750,
830.1800}

45215103
Foitou,
F.
(
2000)
Summary
of
the
Physical­
Chemical
Properties
of
AC
1014109
Herbicide:
Lab
Project
Number:
F­
1452.

Unpublished
study
prepared
by
BASF
Corporation.
5
p.
{
OPPTS
830.6302,
830.6303,830.6314,
830.6315,
830.6316,

830.6320,
830.7000,
830.7100,
830.7300}

45215104
Mason,
S.
(
1998)
Acute
Oral
Toxicity
Study
with
Imazapyr/
Glyphosate
75/
180
g/
l
AS
in
Rats:
Lab
Project
Number:

CYD
606/
982980/
AC:
CYD
606.
Unpublished
study
prepared
by
Huntingdon
Life
Sciences
Ltd.
49
p.
{
OPPTS
870.1100}

45215105
Mason,
S.
(
1998)
Acute
Dermal
Toxicity
Study
with
Imazapyr/
Glyphosate
75/
180
g/
l
AS
in
Rats:
Lab
Project
Number:

CYD
607/
982981/
AC:
CYD
607.
Unpublished
study
prepared
by
Huntingdon
Life
Sciences
Ltd.
47
p.
{
OPPTS
870.1200}

45215106
Hoffman,
G.
(
2000)
Acute
Inhalation
Toxicity
Study
with
Imazapyr/
Glyphosate
75/
180
g/
l
AS
in
Rats:
Lab
Project
Number:
00­
5437:
TOX­
00­
114.
Unpublished
study
prepared
by
Huntingdon
Life
Sciences
Ltd.
92
p.
{
OPPTS
870.1300}
84
45215107
Mason,
S.
(
1998)
Primary
Eye
Irritation
Study
with
Imazapyr/
Glyphosate
75/
180
g/
l
AS
in
Rabbits:
Lab
Project
Number:

CYD
609/
983013/
SE:
CYD
609.
Unpublished
study
prepared
by
Huntingdon
Life
Sciences
Ltd.
49
p.
{
OPPTS
870.2400}

45215108
Mason,
S.
(
1998)
Primary
Dermal
Irritation
Study
with
Imazapyr/
Glyphosate
75/
180
g/
l
AS
in
Rabbits:
Lab
Project
Number:
CYD
608/
982716/
SE:
CYD
608.
Unpublished
study
prepared
by
Huntingdon
Life
Sciences
Ltd.
40
p.
{
OPPTS
870.2500}

45215109
Coleman,
D.
(
1998)
Closed­
Patch
Dermal
Sensitization
Study
with
Imazapyr/
Glyphosate
75/
180
g/
l
AS
in
Guinea
Pigs:

Lab
Project
Number:
CYD
610/
983102/
SS:
CYD
610.
Unpublished
study
prepared
by
Huntingdon
Life
Sciences
Ltd.
59
p.
{
OPPTS
870.2600}

45335300
BASF
Corporation
(
2001)
Submission
of
Environmental
Fate
Data
in
Support
of
the
Registration
of
Lightning
Herbicide.

Transmittal
of
2
Studies.

45335301
Carver,
L.;
Johnson,
L.;
Kleiner,
A.
(
2001)
A
Small­
Scale
Prospective
Groundwater
Monitoring
Study
for
Imazethapyr
on
Corn
in
the
Southeastern
United
States(
Georgia):
Lab
Project
Number:
007­
202:
EXA­
99­
022.04.
Unpublished
study
prepared
by
Research
Options,
Inc.
and
Waterborne
Environmental,
Inc.
98
p.
{
OPPTS
840.2100}

45335302
Carver,
L.;
Johnson,
L.;
Kleiner,
A.
(
2001)
A
Small­
Scale
Prospective
Groundwater
Monitoring
Study
for
Imazethapyr
on
Corn
in
the
Southeastern
United
States(
Indiana):
Lab
Project
Number:
007­
198:
EXA­
99­
021.04.
Unpublished
study
prepared
by
Agsearch
Company
Waterborne
Environmental,
Inc.
176
p.
{
OPPTS
840.2100}

45410000
BASF
Corporation
(
2001)
Submission
of
Environmental
Fate
Data
in
Support
of
the
Registration
of
Lightning
Herbicide.

Transmittal
of
2
Studies.

45410001
Carver,
L.;
Johnson,
L.;
Kleiner,
A.
(
2001)
A
Small­
Scale
Prospective
Groundwater
Monitoring
Study
for
Imazethapyr
on
Corn
in
the
Southeastern
United
States
(
Georgia):
Lab
Project
Number:
EXA­
99­
022.05.
Unpublished
study
prepared
by
Research
Options,
Inc.
and
Waterborne
Environmental,
Inc.
71
p.
{
OPPTS
840.2100}

45410002
Carver,
L.;
Johnson,
L.;
Kleiner,
A.
(
2001)
A
Small­
Scale
Prospective
Groundwater
Monitoring
Study
for
Imazethapyr
on
Corn
in
the
Southeastern
United
States
(
Indiana):
Lab
Project
Number:
007­
198:
EXA­
99­
021.05.
Unpublished
study
prepared
by
Agsearch
Company
and
Waterborne
Environmental,
Inc.
136
p.

45498200
BASF
Agro
Research
(
2001)
Submission
of
Environmental
Fate
Data
in
Support
of
the
Registration
of
Lightning
Herbicide.
Transmittal
of
2
Studies.
85
45498201
Carver,
L.;
Johnson,
L.;
Leonard,
R.
(
2001)
A
Small­
Scale
Prospective
Groundwater
Monitoring
Study
for
Imazethapyr
on
Corn
in
the
Southeastern
United
States
(
Georgia):
Eighth
Progress
Report:
Lab
Project
Number:
EXA­
99­
022.06:
EEA
98­
04:
XA
99­
022.06.
Unpublished
study
prepared
by
Research
Options,
Inc.,
Waterborne
Environmental,
Inc.,
ABC
Laboratories,
and
Exygen
Research.
92
p.
{
OPPTS
840.2100}

45498202
Carver,
L.;
Johnson,
L.;
Leonard,
R.
(
2001)
A
Small­
Scale
Prospective
Groundwater
Monitoring
Study
for
Imazethapyr
on
Corn
in
the
Midwestern
United
States
(
Indiana):
Eighth
Progress
Report:
Lab
Project
Number:
EXA­
99­
021.06:
EEA­

98­
03:
263.08.
Unpublished
study
prepared
by
Agsearch
Company,
Waterborne
Environmental,
Inc.,
ABC
Laboratories,

and
Exygen
Research.
100
p.
{
OPPTS
840.2100}

45663800
BASF
Corp.
(
2002)
Submission
of
Environmental
Fate
Data
in
Support
of
the
Registration
of
Lightning
Herbicide.

Transmittal
of
2
Studies.

45663801
Carver,
L.;
Johnson,
L.;
Leonard,
R.
(
2002)
A
Small­
Scale
Prospective
Groundwater
Monitoring
Study
for
Imazethapyr
(
BAS
685H)
on
Corn
in
the
Southeastern
United
States
(
Georgia):
Lab
Project
Number:
EXA­
99­
022.08:
EEA
98­
04:

RAN
01­
016.
Unpublished
study
prepared
by
Research
Options,
Inc.
118
p.
{
OPPTS
840.2100}

45663802
Carver,
L.;
Johnson,
L.;
Leonard,
R.
(
2002)
A
Small­
Scale
Prospective
Groundwater
Monitoring
Study
for
Imazethapyr
(
BAS
685H)
on
Corn
in
the
Midwestern
United
States
(
Indiana):
Lab
Project
Number:
EXA­
99­
021.08:
EEA
98­
03:

263.08.
Unpublished
study
prepared
by
AGSEARCH
Co.
183
p.
{
OPPTS
840.2100}

45677400
BASF
Agro
Research
(
2002)
Submission
of
Environmental
Fate
Data
in
Support
of
the
Registration
of
LIGHTNING
Herbicide.
Transmittal
of
1
Study.

45677401
Jackson,
S.
(
2002)
Summary
Report:
Request
for
Termination
of
Imazethapyr
Prospective
Groundwater
Studies
at
Two
Sites:
Lab
Project
Number:
2002/
5002811.
Unpublished
study
prepared
by
BASF
Agro
Research.
34
p.
{
OPPTS
840.2100}

46274400
BASF
Corporation
(
2004)
Submission
of
Product
Chemistry
Data
In
Support
of
the
Registration
of
Arsenal
Herbicide
Technical.
Transmittal
of
3
Studies.

46274401
Birk,
J.
(
2004)
Analysis
of
Imazapyr
Herbicide
Technical.
Unpublished
study
prepared
by
BASF
Corporation.
7
p.

46274402
Birk,
J.
(
2004)
Certified
Limits:
(
Imazapyr
Herbicide
Technical).
Unpublished
study
prepared
by
BASF
Corporation.
17
p.
86
46274403
Cortes,
D.
(
2004)
BAS
693
H,
Imazapry
Technical
(
Arsenal
Technical,
AC
243,997):
Discussion
of
Formation
of
Impurities.
Project
Number:
2004/
5000054.
Unpublished
study
prepared
by
BASF
Corporation.
40
p.

46559100
Agan
Chemical
Mfg,
Ltd.
(
2005)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Imazapyr
Technical.
Transmittal
of
4
Studies.

46559101
Gorban,
I.
(
2005)
Imazapyr
Technical
(
Agan)
­
Product
Properties.
Project
Number:
90007803.
Unpublished
study
prepared
by
Makhteshim­
Agan
of
North
America,
Inc.
and
Agan
Chemical
Manufacturers,
Ltd.
105
p.

46559102
Gorban,
I.
(
2005)
Imazapyr
Technical
(
Agan)
­
Five
Lots
Analysis
and
Method
Validation.
Project
Number:
04/
11/
3,

90007751.
Unpublished
study
prepared
by
Agan
Chemical
Manufacturers,
Ltd.
95
p.

46559103
Gorban,
I.
(
2005)
Imazapyr
Technical
(
NUT)
­
Product
Properties.
Project
Number:
90007804.
Unpublished
study
prepared
by
Makhteshim­
Agan
of
North
America,
Inc.
and
Agan
Chemical
Manufacturers,
Ltd.
113
p.

46559104
Gorban,
I.
(
2005)
Imazapyr
Technical
(
NUT)
­
Five
Lots
Analysis
and
Method
Validation.
Project
Number:
04/
11/
4,

90007752.
Unpublished
study
prepared
by
Agan
Chemical
Manufacturers,
Ltd.
95
p.

46624600
Etigra,
LLC
(
2005)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Imazapyr
Technical.
Transmittal
of
10
Studies.

46624601
Kay,
J.
(
2005)
Product
Identity
and
Composition,
Description
of
the
Materials
Used,
Description
of
the
Production
Process,
Discussion
of
the
Formation
of
impurities,
and
Certified
Limits
for
Imazapyr
Technical.
Project
Number:

ET/
200522.
Unpublished
study
prepared
by
Etigra,
LLC,
C/
O
Pyxis
Regulatory
Consulting,
Inc.
72
p.

46624602
Jian,
Y.
(
2005)
Preliminary
Analysis
of
Imazapyr
Technical.
Project
Number:
NC/
2005/
002.
Unpublished
study
prepared
by
Nutrichem
Laboratory
Co.
Ltd.
65
p.

46624603
Jian,
Y.
(
2005)
Chemical
and
Physical
Characteristics
of
Imazapyr
Technical:
Color,
Physical
State,
Odor,
Stability,

Oxidation/
Reduction,
pH,
UV­
Vis,
Melting
Point,
Density,
Dissociation
Constant,
Partition
Coefficient,
Solubility
and
Vapor
Pressure.
Project
Number:
NC/
2005/
003.
Unpublished
study
prepared
by
Nutrichem
Laboratory
Co.
Ltd.
84
p.

46624604
Kay,
J.
(
2005)
Waiver
Request
for
Certain
Data
Requirements
for
Imazapyr
Technical.
Project
Number:
ET/
200523.

Unpublished
study
prepared
by
Etigra,
LLC,
C/
O
Pyxis
Regulatory
Consulting,
Inc.
6
p.

46624605
Mukherjee,
A.
(
2005)
Acute
Oral
Toxicity
of
Imazapyr
Technical
in
Rats.
Project
Number:
5264.
Unpublished
study
prepared
by
Jai
Research
Foundation.
38
p.
87
46624606
Mukherjee,
A.
(
2005)
Acute
Dermal
Toxicity
Study
of
Imazapyr
Technical
in
Rats.
Project
Number:
5265.
Unpublished
study
prepared
by
Jai
Research
Foundation.
39
p.

46624607
Mukherjee,
A.
(
2005)
Acute
Inhalation
Toxicity
Study
of
Imazapyr
Technical
in
Rats.
Project
Number:
5269.

Unpublished
study
prepared
by
Jai
Research
Foundation.
54
p.

46624608
Mukherjee,
A.
(
2005)
Acute
Eye
Irritation
Study
of
Imazapyr
Technical
in
Rabbits.
Project
Number:
5267.
Unpublished
study
prepared
by
Jai
Research
Foundation.
37
p.

46624609
Mukherjee,
A.
(
2005)
Acute
Dermal
Irritation
Study
of
Imazapyr
Technical
in
Rabbits.
Project
Number:
5266.

Unpublished
study
prepared
by
Jai
Research
Foundation.
34
p.

46633300
Etigra,
LLC
(
2005)
Submission
of
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Imazapyr
Technical.

Transmittal
of
1
Study.

46633301
Mukherjee,
A.
(
2005)
Skin
Sensitization
Study
of
Imazapyr
Technical
in
Guinea
Pigs
(
Guinea
Pig
Maximization
Test).

Project
Number:
5268.
Unpublished
study
prepared
by
Jai
Research
Foundation.
53
p.

46683900
PBI/
Gordon
Corporation
(
2005)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Amended
Registration
of
EH
1135
PGR.
Transmittal
of
1
Study.

46683901
Sanson,
D.
(
2005)
Product
Identity
and
Composition
of
EH
1135
PGR.
Unpublished
study
prepared
by
PBI/
Gordon
Corp.

10
p.

46731400
Agan
Chem
MFG,
Ltd
(
2006)
Submission
of
Product
Chemistry
Data
in
Support
of
the
Application
for
Registration
of
Imazapyr
Technical.
Transmittal
of
1
Study.

46731401
Gorban,
I.
(
2006)
Imazapyr
Technical
­
Product
Properties
(
NUT)
(
AGAN).
Project
Number:
JR/
1/
9/
06.
Unpublished
study
prepared
by
Agan
Chem
MFG,
Ltd.
10
p.

46775500
Vegetation
Management,
LLC
(
2006)
Submission
of
Product
Chemistry
and
Toxicity
Data
in
Support
of
the
Application
for
Registration
of
Mohave
70
EG.
Transmittal
of
7
Studies.

46775502
Woolley,
A.;
Mullee,
D.
(
2005)
Determination
of
Physico­
Chemical
Properties:
Mohave
70
EG:
AGN­
SAH02.
Project
Number:
008/
595.
Unpublished
study
prepared
by
Safepharm
Laboratories
Ltd.
22
p.

46775503
Sanders,
A.
(
2005)
Acute
Oral
Toxicity
in
the
Rat
­
Up
and
Down
Procedure:
Mohave
7
EG:
AGN­
SAH02.
Project
Number:
008/
596.
Unpublished
study
prepared
by
Safepharm
Laboratories
Ltd.
16
p.
88
46775504
Sanders,
A.
(
2005)
Acute
Dermal
Toxicity
(
Limit
Test)
in
the
Rat:
Mohave
70
EG:
AGN­
SAH02.
Project
Number:

008/
598.
Unpublished
study
prepared
by
Safepharm
Laboratories
Ltd.
19
p.

46775505
Griffiths,
D.
(
2005)
Acute
Inhalation
Toxicity
(
Nose
Only)
Study
in
the
Rat:
AGN­
SAH02.
Project
Number:
008/
597.

Unpublished
study
prepared
by
Safepharm
Laboratories
Ltd.
32
p.

46775506
Sanders,
A.
(
2005)
Acute
Eye
Irritation
in
the
Rabbit:
Mohave
7
EG:
AGN­
SAH02.
Project
Number:
008/
600.

Unpublished
study
prepared
by
Safepharm
Laboratories
Ltd.
18
p.

46775507
Sanders,
A.
(
2005)
Acute
Dermal
Irritation
in
the
Rabbit:
AGN­
SAH02.
Project
Number:
008/
599.
Unpublished
study
prepared
by
Safepharm
Laboratories
Ltd.
14
p.

46775508
Hathorn,
S.
(
2005)
Skin
Sensitisation
in
the
Guinea­
Pig­
Buehler
Test
Method:
Mohave
70
EG:
AGN­
SAH02.
Project
Number:
TL/
277/
05/
1690,
0008/
601.
Unpublished
study
prepared
by
Safepharm
Laboratories
Ltd.
25
p.
89
Appendix
E.
GENERIC
DATA
CALL­
IN
Note
that
a
complete
Data
Call­
In
(
DCI),
with
all
pertinent
instructions,
will
be
sent
to
registrants
under
separate
cover.
90
Appendix
F.
PRODUCT
SPECIFIC
DATA
CALL­
IN
Note
that
a
complete
Data
Call­
In
(
DCI),
with
all
pertinent
instructions,
will
be
sent
to
registrants
under
separate
cover.
91
Appendix
G.
EPA'S
BATCHING
OF
IMAZAPYR
PRODUCTS
FOR
MEETING
ACUTE
TOXICITY
DATA
REQUIREMENTS
FOR
REREGISTRATION
In
an
effort
to
reduce
the
time,
resources
and
number
of
animals
needed
to
fulfill
the
acute
toxicity
data
requirements
for
reregistration
of
products
containing
IMAZAPYR
as
the
active
ingredient,
the
Agency
has
batched
products
which
can
be
considered
similar
for
purposes
of
acute
toxicity.
Factors
considered
in
the
sorting
process
include
each
product's
active
and
inert
ingredients
(
identity,
percent
composition
and
biological
activity),
type
of
formulation
(
e.
g.,
emulsifiable
concentrate,
aerosol,
wettable
powder,
granular,
etc.),
and
labeling
(
e.
g.,
signal
word,
use
classification,
precautionary
labeling,
etc.).
Note
that
the
Agency
is
not
describing
batched
products
as
"
substantially
similar"
since
some
products
within
a
batch
may
not
be
considered
chemically
similar
or
have
identical
use
patterns.

Using
available
information,
batching
has
been
accomplished
by
the
process
described
in
the
preceding
paragraph.
Notwith­
standing
the
batching
process,
the
Agency
reserves
the
right
to
require,
at
any
time,
acute
toxicity
data
for
an
individual
product
should
the
need
arise.

Registrants
of
products
within
a
batch
may
choose
to
cooperatively
generate,
submit
or
cite
a
single
battery
of
six
acute
toxicological
studies
to
represent
all
the
products
within
that
batch.
It
is
the
registrants'
option
to
participate
in
the
process
with
all
other
registrants,
only
some
of
the
other
registrants,
or
only
their
own
products
within
a
batch,
or
to
generate
all
the
required
acute
toxicological
studies
for
each
of
their
own
products.
If
a
registrant
chooses
to
generate
the
data
for
a
batch,
he/
she
must
use
one
of
the
products
within
the
batch
as
the
test
material.
If
a
registrant
chooses
to
rely
upon
previously
submitted
acute
toxicity
data,
he/
she
may
do
so
provided
that
the
data
base
is
complete
and
valid
by
today's
standards
(
see
acceptance
criteria
attached),
the
formulation
tested
is
considered
by
EPA
to
be
similar
for
acute
toxicity,
and
the
formulation
has
not
been
significantly
altered
since
submission
and
acceptance
of
the
acute
toxicity
data.
Regardless
of
whether
new
data
is
generated
or
existing
data
is
referenced,
registrants
must
clearly
identify
the
test
material
by
EPA
Registration
Number.
If
more
than
one
confidential
statement
of
formula
(
CSF)
exists
for
a
product,
the
registrant
must
indicate
the
formulation
actually
tested
by
identifying
the
corresponding
CSF.

In
deciding
how
to
meet
the
product
specific
data
requirements,
registrants
must
follow
the
directions
given
in
the
Data
Call­
In
Notice
and
its
attachments
appended
to
the
RED.
The
DCI
Notice
contains
two
response
forms
which
are
to
be
completed
and
submitted
to
the
Agency
within
90
days
of
receipt.
The
first
form,
"
Data
Call­
In
Response,"
asks
whether
the
registrant
will
meet
the
data
requirements
for
each
product.
The
second
form,
"
Requirements
Status
and
Registrant's
Response,"
lists
the
product
specific
data
required
for
each
product,
including
the
standard
six
acute
toxicity
tests.
A
registrant
who
wishes
to
participate
in
a
batch
must
decide
whether
he/
she
will
provide
the
data
or
depend
on
someone
else
to
do
so.
If
a
registrant
supplies
the
data
to
support
a
batch
of
products,
he/
she
must
select
one
of
the
following
options:
Developing
Data
(
Option
1),
Submitting
an
Existing
Study
(
Option
4),
Upgrading
an
Existing
Study
(
Option
5)
or
Citing
an
Existing
Study
(
Option
6).
If
a
registrant
depends
on
another's
data,
he/
she
must
choose
among:
Cost
Sharing
(
Option
2),
Offers
to
Cost
Share
(
Option
3)
or
Citing
an
Existing
Study
(
Option
6).
If
a
registrant
does
not
want
to
participate
in
a
batch,
the
choices
are
Options
1,
4,
5
or
6.
However,
a
92
registrant
should
know
that
choosing
not
to
participate
in
a
batch
does
not
preclude
other
registrants
in
the
batch
from
citing
his/
her
studies
and
offering
to
cost
share
(
Option
3)
those
studies.

Thirty
eight
products
were
found
which
contain
Imazapyr
as
the
active
ingredient.
These
products
have
been
placed
eight
batches
and
a
no
batch
group
in
accordance
with
the
active
and
inert
ingredients
and
type
of
formulation.

Batching
Instructions:

No
Batch:
Each
product
in
this
Batch
should
generate
their
own
data.

NOTE:
The
technical
acute
toxicity
values
included
in
this
document
are
for
informational
purposes
only.
The
data
supporting
these
values
may
or
may
not
meet
the
current
acceptance
criteria.

Batch
1
EPA
Reg.
No.
Percent
Active
Ingredient
241­
286
95.0
11603­
42
95.0
Batch
2
EPA
Reg.
No.
Percent
Active
Ingredient
241­
387
75.0
241­
402
75.0
Batch
3
EPA
Reg.
No.
Percent
Active
Ingredient
228­
480
53.1
241­
299
53.1
241­
401
53.1
34704­
908
53.1
61202­
1
53.1
Batch
4
EPA
Reg.
No.
Percent
Active
Ingredient
241­
346
28.7
241­
426
28.7
34704­
896
28.7
93
Batch
5
EPA
Reg.
No.
Percent
Active
Ingredient
241­
273
27.6
241­
296
27.6
241­
336
27.6
241­
398
27.6
34704­
905
27.6
Batch
6
EPA
Reg.
No.
Percent
Active
Ingredient
241­
308
5.0
34913­
24
5.0
Batch
7
EPA
Reg.
No.
Percent
Active
Ingredient
228­
307
0.5
241­
295
0.5
34913­
23
0.5
Batch
8
EPA
Reg.
No.
Percent
Active
Ingredient
228­
308
Imazapyr:
0.5
Diuron:
2.0
241­
344
Imazapyr:
0.5
Diuron:
2.0
13283­
19
Imazapyr:
0.5
Diuron:
2.0
34913­
22
Imazapyr:
0.5
Diuron:
2.0
94
No
Batch
EPA
Reg.
No.
Percent
Active
Ingredient
239­
2622
Imazapyr:
0.080
Oxyfluorfen:
0.700
239­
2657
Imazapyr:
0.080
Glyphosate:
5.000
239­
2686
Imazapyr:
0.016
Glyphosate:
1.000
241­
294
14.200
241­
330
3.600
241­
372
Imazapyr:
7.780
Diuron:
62.220
241­
377
Imazapyr:
17.500
Imazethapyr:
52.500
241­
384
Imazapyr:
4.000
Imazethapyr:
12.000
Benzoic
Acid:
58.900
241­
400
Imazapyr:
5.050
Imazethapyr:
15.150
241­
414
Imazapyr:
8.360
Glyphosate:
22.130
2217­
802
Imazapyr:
0.150
Acetamide:
21.450
Imazethapyr:
4.090
62719­
526
Imazapyr:
2.390
Glyphosate:
31.380
95
Appendix
H.
LIST
OF
REGISTRANTS
SENT
THIS
DATA
CALL­
IN
NOTICE
1.
BASF
Corporation.

2.
Nufarm
Americas,
Inc.

3.
PBI/
Gordon
Corporation.

4.
Agan
Chemical
MFG,
Ltd.

5.
Rainbow
Technology
Corporation.

7.
SSI
Maxim
Company,
Inc.

8.
Vegetation
Management,
LLC.

9.
Etigra,
LLC.
96
Appendix
I.
LIST
OF
AVAILABLE
RELATED
DOCUMENTS
AND
ELECTRONICALLY
AVAILABLE
FORMS
Pesticide
Registration
Forms
are
available
at
the
following
EPA
internet
site:

http://
www.
epa.
gov/
opprd001/
forms/.

Pesticide
Registration
Forms
(
These
forms
are
in
PDF
format
and
require
the
Acrobat
reader)

Instructions:

1.
Print
out
and
complete
the
forms.
(
Note:
Form
numbers
that
are
bolded
can
be
filled
out
on
your
computer
then
printed.)

2.
The
completed
form(
s)
should
be
submitted
in
hardcopy
in
accord
with
the
existing
policy.

3.
Mail
the
forms,
along
with
any
additional
documents
necessary
to
comply
with
EPA
regulations
covering
your
request,
to
the
address
below
for
the
Document
Processing
Desk.

DO
NOT
fax
or
e­
mail
any
form
containing
'
Confidential
Business
Information'
or
'
Sensitive
Information.'

If
you
have
any
problems
accessing
these
forms,
please
contact
Nicole
Williams
at
(
703)
308­
5551
or
by
e­
mail
at
williams.
nicole@
epamail.
epa.
gov.
97
The
following
Agency
Pesticide
Registration
Forms
are
currently
available
via
the
Internet
at
the
following
locations:

8570­
1
Application
for
Pesticide
Registration/
Amendment
http://
www.
epa.
gov/
opprd001/
forms/
8570­
1.
pdf.

8570­
4
Confidential
Statement
of
Formula
http://
www.
epa.
gov/
opprd001/
forms/
8570­
4.
pdf.

8570­
5
Notice
of
Supplemental
Registration
of
Distribution
of
a
Registered
Pesticide
Product
http://
www.
epa.
gov/
opprd001/
forms/
8570­
5.
pdf.

8570­
17
Application
for
an
Experimental
Use
Permit
http://
www.
epa.
gov/
opprd001/
forms/
8570­
17.
pdf.

8570­
25
Application
for/
Notification
of
State
Registration
of
a
Pesticide
To
Meet
a
Special
Local
Need
http://
www.
epa.
gov/
opprd001/
forms/
8570­
25.
pdf.

8570­
27
Formulator's
Exemption
Statement
http://
www.
epa.
gov/
opprd001/
forms/
8570­
27.
pdf.

8570­
28
Certification
of
Compliance
with
Data
Gap
Procedures
http://
www.
epa.
gov/
opprd001/
forms/
8570­
28.
pdf.

8570­
30
Pesticide
Registration
Maintenance
Fee
Filing
http://
www.
epa.
gov/
opprd001/
forms/
8570­
30.
pdf.

8570­
32
Certification
of
Attempt
to
Enter
into
an
Agreement
with
other
Registrants
for
Development
of
Data
http://
www.
epa.
gov/
opprd001/
forms/
8570­
32.
pdf.

8570­
34
Certification
with
Respect
to
Citations
of
Data
(
in
PR
Notice
98­
5)
http://
www.
epa.
gov/
opppmsd1/
PR_
Notices/
pr9
8­
5.
pdf.

8570­
35
Data
Matrix
(
in
PR
Notice
98­
5)
http://
www.
epa.
gov/
opppmsd1/
PR_
Notices/
pr9
8­
5.
pdf.

8570­
36
Summary
of
the
Physical/
Chemical
Properties
(
in
PR
Notice
98­
1)
http://
www.
epa.
gov/
opppmsd1/
PR_
Notices/
pr9
8­
1.
pdf.

8570­
37
Self­
Certification
Statement
for
the
Physical/
Chemical
Properties
(
in
PR
Notice
98­
1)
http://
www.
epa.
gov/
opppmsd1/
PR_
Notices/
pr9
8­
1.
pdf.
98
Pesticide
Registration
Kit
www.
epa.
gov/
pesticides/
registrationkit/

Dear
Registrant:

For
your
convenience,
we
have
assembled
an
online
registration
kit
which
contains
the
following
pertinent
forms
and
information
needed
to
register
a
pesticide
product
with
the
U.
S.
Environmental
Protection
Agency's
Office
of
Pesticide
Programs
(
OPP):

1.
The
Federal
Insecticide,
Fungicide,
and
Rodenticide
Act
(
FIFRA)
and
the
Federal
Food,
Drug
and
Cosmetic
Act
(
FFDCA)
as
Amended
by
the
Food
Quality
Protection
Act
(
FQPA)
of
1996.

2.
Pesticide
Registration
(
PR)
Notices
a.
83­
3
Label
Improvement
Program­­
Storage
and
Disposal
Statements
b.
84­
1
Clarification
of
Label
Improvement
Program
c.
86­
5
Standard
Format
for
Data
Submitted
under
FIFRA
d.
87­
1
Label
Improvement
Program
for
Pesticides
Applied
through
Irrigation
Systems
(
Chemigation)
e.
87­
6
Inert
Ingredients
in
Pesticide
Products
Policy
Statement
f.
90­
1
Inert
Ingredients
in
Pesticide
Products;
Revised
Policy
Statement
g.
95­
2
Notifications,
Non­
notifications,
and
Minor
Formulation
Amendments
h.
98­
1
Self
Certification
of
Product
Chemistry
Data
with
Attachments
(
This
document
is
in
PDF
format
and
requires
the
Acrobat
reader.)

Other
PR
Notices
can
be
found
at
http://
www.
epa.
gov/
opppmsd1/
PR_
Notices.

3.
Pesticide
Product
Registration
Application
Forms
(
These
forms
are
in
PDF
format
and
will
require
the
Acrobat
reader.)

a.
EPA
Form
No.
8570­
1,
Application
for
Pesticide
Registration/
Amendmentb.
EPA
Form
No.
8570­
4,
Confidential
Statement
of
Formula
c.
EPA
Form
No.
8570­
27,
Formulator's
Exemption
Statement
d.
EPA
Form
No.
8570­
34,
Certification
with
Respect
to
Citations
of
Data
e.
EPA
Form
No.
8570­
35,
Data
Matrix
4.
General
Pesticide
Information
(
Some
of
these
forms
are
in
PDF
format
and
will
require
the
Acrobat
reader.)

a.
Registration
Division
Personnel
Contact
List
Biopesticides
and
Pollution
Prevention
Division
(
BPPD)
Contacts
Antimicrobials
Division
Organizational
Structure/
Contact
List
b.
53
F.
R.
15952,
Pesticide
Registration
Procedures;
Pesticide
Data
Requirements
(
PDF
format)
c.
40
CFR
Part
156,
Labeling
Requirements
for
Pesticides
and
Devices
(
PDF
format)
d.
40
CFR
Part
158,
Data
Requirements
for
Registration
(
PDF
format)
e.
50
F.
R.
48833,
Disclosure
of
Reviews
of
Pesticide
Data
(
November
27,
1985)

Before
submitting
your
application
for
registration,
you
may
wish
to
consult
some
additional
sources
of
information.
These
include:

1.
The
Office
of
Pesticide
Programs'
Web
Site
99
2.
The
booklet
"
General
Information
on
Applying
for
Registration
of
Pesticides
in
the
United
States",
PB92­
221811,
available
through
the
National
Technical
Information
Service
(
NTIS)
at
the
following
address:

National
Technical
Information
Service
(
NTIS)
5285
Port
Royal
Road
Springfield,
VA
22161
The
telephone
number
for
NTIS
is
(
703)
605­
6000.
Please
note
that
EPA
is
currently
in
the
process
of
updating
this
booklet
to
reflect
the
changes
in
the
registration
program
resulting
from
the
passage
of
the
FQPA
and
the
reorganization
of
the
Office
of
Pesticide
Programs.
We
anticipate
that
this
publication
will
become
available
during
the
Fall
of
1998.

3.
The
National
Pesticide
Information
Retrieval
System
(
NPIRS)
of
Purdue
University's
Center
for
Environmental
and
Regulatory
Information
Systems.
This
service
does
charge
a
fee
for
subscriptions
and
custom
searches.
You
can
contact
NPIRS
by
telephone
at
(
765)
494­
6614
or
through
their
Web
site.

4.
The
National
Pesticide
Telecommunications
Network
(
NPTN)
can
provide
information
on
active
ingredients,
uses,
toxicology,
and
chemistry
of
pesticides.
You
can
contact
NPTN
by
telephone
at
(
800)
858­
7378
or
through
their
Web
site:
ace.
orst.
edu/
info/
nptn.

The
Agency
will
return
a
notice
of
receipt
of
an
application
for
registration
or
amended
registration,
experimental
use
permit,
or
amendment
to
a
petition
if
the
applicant
or
petitioner
encloses
with
his
submission
a
stamped,
self­
addressed
postcard.
The
postcard
must
contain
the
following
entries
to
be
completed
by
OPP:

 
Date
of
receipt
 
EPA
identifying
number
 
Product
Manager
assignment
Other
identifying
information
may
be
included
by
the
applicant
to
link
the
acknowledgment
of
receipt
to
the
specific
application
submitted.
EPA
will
stamp
the
date
of
receipt
and
provide
the
EPA
identifying
File
Symbol
or
petition
number
for
the
new
submission.
The
identifying
number
should
be
used
whenever
you
contact
the
Agency
concerning
an
application
for
registration,
experimental
use
permit,
or
tolerance
petition.

To
assist
us
in
ensuring
that
all
data
you
have
submitted
for
the
chemical
are
properly
coded
and
assigned
to
your
company,
please
include
a
list
of
all
synonyms,
common
and
trade
names,
company
experimental
codes,
and
other
names
which
identify
the
chemical
(
including
"
blind"
codes
used
when
a
sample
was
submitted
for
testing
by
commercial
or
academic
facilities).
Please
provide
a
CAS
number
if
one
has
been
assigned.
100
Documents
Associated
with
this
RED
The
following
documents
are
part
of
the
Administrative
Record
for
this
RED
document
and
may
be
included
in
the
EPA's
Office
of
Pesticide
Programs
Public
Docket.
Copies
of
these
documents
are
not
available
electronically,
but
may
be
obtained
by
contacting
the
person
listed
on
the
respective
Chemical
Status
Sheet.

1.
Health
Effects
Division
and
Environmental
Fate
and
Effects
Division
Science
Chapters,
which
include
the
complete
risk
assessments
and
supporting
documents.

2.
Detailed
Luis
Report.