Document ID: EPA-HQ-OPPT-2003-0027-0017
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2003-08-08T04:00Z

1
uterotrophic,
Hershberger,
steroidogenesis,
aromatase,
ER
binding/
transcriptional
activation,
AR
binding/
transcriptional
activation,
pubertal
male,
pubertal
female,
adult
male,
mammalian
2­
generation
Questions
for
EDMVS
on
strain/
species
for
mammalian
assays
in
the
Endocrine
Disruptor
Screening
Program
August
2003
1.
Are
there
any
mammalian
assays
being
considered
for
the
EDSP
in
which
a
specific
strain
should
be
used
or
avoided?
1
2.
Should
EPA
standardize
on
one
strain
across
all
assays?
a.
if
different
strains
are
best
for
different
assays
b.
if
no
strain
is
preferred
for
any
of
the
assays
3.
Should
EPA
require
the
use
of
multiple
inbred
strains?
If
so,
a.
for
which
assays?
b.
how
many
strains?
c.
which
strains?
d.
should
the
total
number
of
animals
used
in
the
assay
be
kept
the
same
as
if
only
one
strain
were
used,
or
should
each
strain
be
tested
with
the
full
complement
of
animals?

4.
Is
there
sufficient
reason
to
switch
from
rats
to
a
different
test
species?
If
so,
which
species?