Document ID: EPA-HQ-OPPT-2019-0500-0028
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2020-02-26T05:00Z

README FILE
 TCE.1.2.3.3 Directory
 README.docx  -  This file
 TCE.evaluation.1.2.3.3.pop.model  -  MCSim model file for MCMC simulations
 TCE.risk5.1.2.3.3.pop.model  -  MCSim model file for dose metric predictions
 mcsimstd.TCE.evaluation.1.2.3.3.pop.exe  -  Windows executable for MCMC simulations
 mcsimstd.TCE.risk5.1.2.3.3.pop.exe  -  Windows executable for dose metric predictions
 ModelResults.R  -  R script for generating plots of model results
 funcdefs.R  -  R script with functions used in ModelResults.R script
 OutputVar-labels-plot.csv  -  CSV file with labels for model outputs
Mouse subdirectory
 Mouse.addldata.Kim.datalabs.txt  -  data labels for validation data from Kim et al.
 Mouse.check.addldata.Kim-rev.5.pdf  -  PDF of comparison of model with Kim et al.
 Mouse.check.x.5.pdf  -  PDF of comparison of distribution of model predictions with calibration data
 Mouse.checkone.5.pdf  -  PDF of comparison of single random prediction with calibration data
 Mouse.checkone.two.5.pdf  -  PDF of comparison of distribution of model predictions, and population mean predictions, with calibration data
 Mouse.datalabs.txt  -  data labels for calibration data
 TCE.1.2.3.3.Mouse.pop.1.5.in  -  MCMC in file (chain 1)
 TCE.1.2.3.3.Mouse.pop.1.5.out  -  MCMC out file (chain 1)
 TCE.1.2.3.3.Mouse.pop.2.5.in  -  MCMC in file (chain 2)
 TCE.1.2.3.3.Mouse.pop.2.5.out  -  MCMC out file (chain 2)
 TCE.1.2.3.3.Mouse.pop.3.5.in  -  MCMC in file (chain 3)
 TCE.1.2.3.3.Mouse.pop.3.5.out   -  MCMC out file (chain 3)
 TCE.1.2.3.3.Mouse.pop.4.5.in  -  MCMC in file (chain 4)
 TCE.1.2.3.3.Mouse.pop.4.5.out   -  MCMC out file (chain 4)
 TCE.1.2.3.3.Mouse.pop.check.x.5.in  -  in file to generate distribution of predictions
 TCE.1.2.3.3.Mouse.pop.check.x.5.out  -  out file with distribution of predictions
 TCE.1.2.3.3.Mouse.pop.checkone.1.5.in  -  in file to generate single random prediction
 TCE.1.2.3.3.Mouse.pop.checkone.1.5.out  -  out file with single random prediction
 TCE.1.2.3.3.Mouse.pop.mean.check.x.5.in  -  in file to generate population mean predictions 
 TCE.1.2.3.3.Mouse.pop.mean.check.x.5.out  -  out file with population mean predictions
 TCE.1.2.3.3.Mouse.pop.mean.x.5.out  -  parameter file for population mean predictions
 TCE.1.2.3.Mouse.pop.1.4.restart.out  -  restart file (initial conditions) for MCMC chain 1
 TCE.1.2.3.Mouse.pop.2.4.restart.out  -  restart file (initial conditions) for MCMC chain 2
 TCE.1.2.3.Mouse.pop.3.4.restart.out  -  restart file (initial conditions) for MCMC chain 3
 TCE.1.2.3.Mouse.pop.4.4.restart.out  -  restart file (initial conditions) for MCMC chain 4
Mouse/Parms2 subdirectory:
 TCE.1.2.3.3.Mouse.pop.genparms.setpoints.parmsonly.x.5.out  -  out file for posterior parameter distributions
 TCE.1.2.3.3.Mouse.pop.genparms.setpoints.x.5.in  -  in file for parameter distributions
 TCE.1.2.3.3.Mouse.pop.posterior.x.5.dat  -  parameter file for parameter posteriors
 TCE.1.2.3.3.Mouse.pop.prior.x.5.dat  -  output file with prior summaries
 TCE.1.2.3.3.Mouse.pop.priors.genparms.setpoints.parmsonly.x.5.out  -  out file for prior parameter distributions
 TCE.1.2.3.3.Mouse.pop.priors.genparms.setpoints.x.5.in  -  in file for prior parameter distributions
 TCE.1.2.3.3.Mouse.pop.priors.mc.x.5.in  -  in file for generating prior scaling parameter 
 TCE.1.2.3.3.Mouse.pop.priors.mc.x.5.out  -  out file of prior scaling parameters
 TCE.1.2.3.3.Mouse.pop.priors.rep500.x.5.out  -  out file with 500 replicates of scaling parameters

Mouse/PopPred subdirectory
 Mouse.posteriors.x.5.pdf  -  PDF of posterior population distributions
 TCE.1.2.3.3.Mouse.pop.genpop.setpoints.x.5.in  -  in file for posterior population distributions
 TCE.1.2.3.3.Mouse.pop.genpop.setpoints.x.5.out  -  out file for posterior population distributions
 TCE.1.2.3.3.Mouse.pop.poppred.addldata.Kim.x.5.out  -  out file for validation data
 TCE.1.2.3.3.Mouse.pop.poppred.x.5.in  -  in file for population predictions
 TCE.1.2.3.3.Mouse.pop.poppred.x.5.out  -  out file for population predictions
 TCE.1.2.3.3.Mouse.pop.x.5.out  -  parameter file with posterior parameters

Rat.seqpriors.test4 subdirectory
 Rat.seqpriors.test4.addldata.Liu.datalabs.txt  -  data labels for validation data from Liu et al.
 Rat.seqpriors.test4.addldata.datalabs.txt  -  data labels for validation data
 Rat.seqpriors.test4.check.addldata.10.pdf  -  PDF of comparison of model with Liu et al.
 Rat.seqpriors.test4.check.addldata.Liu.10.pdf  -  PDF of comparison of model with validation data
 Rat.seqpriors.test4.check.x.10.pdf  -  PDF of comparison of distribution of model predictions with calibration data
 Rat.seqpriors.test4.checkone.10.pdf  -  PDF of comparison of single random prediction with calibration data
 Rat.seqpriors.test4.checkone.two.10.pdf  -  PDF of comparison of distribution of model predictions, and population mean predictions, with calibration data
 Rat.seqpriors.test4.datalabs.txt  -  data labels for calibration data
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.1.10.in  -  MCMC in file (chain 1)
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.1.10.out  -  MCMC out file (chain 1)
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.2.10.in  -  MCMC in file (chain 2)
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.2.10.out  -  MCMC out file (chain 2)
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.3.10.in  -  MCMC in file (chain 3)
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.3.10.out   -  MCMC out file (chain 3)
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.4.10.in  -  MCMC in file (chain 4)
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.4.10.out   -  MCMC out file (chain 4)
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.check.x.10.in  -  in file to generate distribution of predictions
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.check.x.10.out  -  out file with distribution of predictions
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.checkone.1.10.in  -  in file to generate single random prediction
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.checkone.1.10.out  -  out file with single random prediction
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.mean.check.x.10.in  -  in file to generate population mean predictions
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.mean.check.x.10.out  -  out file with population mean predictions
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.mean.x.10.out   -  parameter file for population mean predictions

Rat.seqpriors.test4/Parms2 subdirectory
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.genparms.setpoints.parmsonly.x.10.out  -  out file for posterior parameter distributions
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.genparms.setpoints.x.10.in  -  in file for parameter distributions
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.posterior.x.10.dat  -  parameter file for parameter posteriors
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.prior.x.10.dat  -  output file with prior summaries
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.priors.genparms.setpoints.parmsonly.x.10.out  -  out file for prior parameter distributions
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.priors.genparms.setpoints.x.10.in  -  in file for prior parameter distributions
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.priors.mc.x.10.in   -  in file for generating prior scaling parameter
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.priors.mc.x.10.out  -  out file of prior scaling parameters
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.priors.rep500.x.10.out  -  out file with 500 replicates of scaling parameters

Rat.seqpriors.test4/PopPred subdirectory
 Rat.seqpriors.test4.posteriors.x.10.pdf  -  PDF of posterior population distributions
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.genpop.setpoints.x.10.in   -  in file for posterior population distributions
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.genpop.setpoints.x.10.out   -  out file for posterior population distributions
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.poppred.addldata.Liu.x.10.out  -  out file for validation data
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.poppred.addldata.x.10.in  -  in file for validation data
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.poppred.addldata.x.10.out  -  out file for validation data
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.poppred.x.10.in   -  in file for population predictions
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.poppred.x.10.out   -  out file for population predictions
 TCE.1.2.3.3.Rat.seqpriors.test4.pop.x.10.out  -  parameter file with posterior parameters

Human.seqpriors.v1 subdirectory
 Human.seqpriors.v1.addldata.datalabs.txt  -  data labels for validation data
 Human.seqpriors.v1.check.addldata.23.pdf  -  PDF of comparison of model with validation data
 Human.seqpriors.v1.check.x.23b.pdf  -  PDF of comparison of distribution of model predictions with calibration data
 Human.seqpriors.v1.checkone.9.pdf  -  PDF of comparison of single random prediction with calibration data
 Human.seqpriors.v1.checkone.two.23b.pdf  -  PDF of comparison of distribution of model predictions, and population mean predictions, with calibration data
 Human.seqpriors.v1.datalabs.txt
 TCE.1.2.3.3.Human.seqpriors.v1.pop.1.10.in  -  MCMC in file (chain 1)
 TCE.1.2.3.3.Human.seqpriors.v1.pop.1.23.out  -  MCMC out file (chain 1)
 TCE.1.2.3.3.Human.seqpriors.v1.pop.2.10.in  -  MCMC in file (chain 2)
 TCE.1.2.3.3.Human.seqpriors.v1.pop.2.23.out  -  MCMC out file (chain 2)
 TCE.1.2.3.3.Human.seqpriors.v1.pop.3.10.in  -  MCMC in file (chain 3)
 TCE.1.2.3.3.Human.seqpriors.v1.pop.3.23.out   -  MCMC out file (chain 3)
 TCE.1.2.3.3.Human.seqpriors.v1.pop.4.10.in  -  MCMC in file (chain 4)
 TCE.1.2.3.3.Human.seqpriors.v1.pop.4.123.out   -  MCMC out file (chain 4)
 TCE.1.2.3.3.Human.seqpriors.v1.pop.check.x.23.in  -  data labels for calibration data
 TCE.1.2.3.3.Human.seqpriors.v1.pop.check.x.23.out   -  in file to generate distribution of predictions
 TCE.1.2.3.3.Human.seqpriors.v1.pop.check.x.23b.out   -  out file with distribution of predictions
 TCE.1.2.3.3.Human.seqpriors.v1.pop.checkone.1.9.in  -  in file to generate single random prediction
 TCE.1.2.3.3.Human.seqpriors.v1.pop.checkone.1.9.out   -  out file with single random prediction
 TCE.1.2.3.3.Human.seqpriors.v1.pop.mean.check.x.23.in   -  in file to generate population mean predictions
 TCE.1.2.3.3.Human.seqpriors.v1.pop.mean.check.x.23.out  -  out file with population mean predictions
 TCE.1.2.3.3.Human.seqpriors.v1.pop.mean.x.23.out  -  parameter file for population mean predictions

Human.seqpriors.v1/Parms2 subdirectory
 TCE.1.2.3.3.Human.seqpriors.v1.pop.genparms.setpoints.parmsonly.x.23.out  -  out file for posterior parameter distributions
 TCE.1.2.3.3.Human.seqpriors.v1.pop.genparms.setpoints.x.23.in  -  in file for parameter distributions
 TCE.1.2.3.3.Human.seqpriors.v1.pop.posterior.x.23.dat  -  parameter file for parameter posteriors
 TCE.1.2.3.3.Human.seqpriors.v1.pop.prior.x.23.dat   -  output file with prior summaries
 TCE.1.2.3.3.Human.seqpriors.v1.pop.priors.genparms.setpoints.parmsonly.x.23.out out file for prior parameter distributions
 TCE.1.2.3.3.Human.seqpriors.v1.pop.priors.genparms.setpoints.x.23.in  -  in file for prior parameter distributions
 TCE.1.2.3.3.Human.seqpriors.v1.pop.priors.mc.x.23.in  -  in file for generating prior scaling parameter
 TCE.1.2.3.3.Human.seqpriors.v1.pop.priors.mc.x.23.out  -  out file of prior scaling parameters
 TCE.1.2.3.3.Human.seqpriors.v1.pop.priors.rep500.x.23.out   -  out file with 500 replicates of scaling parameters

ATSDR-comparison subdirectory
 TCE.1.2.3.3.Human.seqpriors.v1.pop.noncancer.3.1d.inter.setpoints.x.23.in  -  in file for 1 day intermittent exposure
 TCE.1.2.3.3.Human.seqpriors.v1.pop.noncancer.3.1d.inter.setpoints.x.23.out  -  out file for 1 day intermittent exposure
 TCE.1.2.3.3.Human.seqpriors.v1.pop.noncancer.3.3wks.inter.setpoints.x.23.in  -  in file for 3 week intermittent exposure
 TCE.1.2.3.3.Human.seqpriors.v1.pop.noncancer.3.3wks.inter.setpoints.x.23.out  -  out file for 3 week intermittent exposure
 TCE.1.2.3.3.Human.seqpriors.v1.pop.noncancer.3.40wks.inter.setpoints.x.23.in  -  in file for 40 week intermittent exposure
 TCE.1.2.3.3.Human.seqpriors.v1.pop.noncancer.3.40wks.inter.setpoints.x.23.out  -  out file for 40 week intermittent exposure
 TCE.1.2.3.3.Human.seqpriors.v1.pop.noncancer.3.52wks.setpoints.x.23.in  -  in file for 52 week continuous exposure
 TCE.1.2.3.3.Human.seqpriors.v1.pop.noncancer.3.52wks.setpoints.x.23.out  -  out file for 52 week continuous exposure
 TCE.1.2.3.3.Human.seqpriors.v1.pop.noncancer.3.setpoints.x.23.in  -  in file for 100 week continuous exposure
 TCE.1.2.3.3.Human.seqpriors.v1.pop.noncancer.3.setpoints.x.23.out  -  in file for 100 week continuous exposure (This file used to calculated summary statistics tabulated in HumanDoseMetricsSummary-forNCEA.xlsx)
 TCE.1.2.3.3.Human.seqpriors.v1.pop.x.23.out  -  posterior parameter file
 TCE.risk6.1.2.3.3.pop.model  -  Model file for dose metrics
 mcsimstd.TCE.risk6.1.2.3.3.pop.static.exe  -  Windows executable file for model