Document ID: EPA-HQ-OPPT-2002-0026-0001
Agency: epa
Document Type: Notice
Title: Fiftieth Report to the TSCA Interagency Testing Committee to the Administrator of the 
Environmental Protection Agency; Receipt of Report and Request for Comments
Posted Date: 2002-07-30T04:00Z

Tuesday,

July
30,
2002
Part
V
Environmental
Protection
Agency
Fiftieth
Report
of
the
TSCA
Interagency
Testing
Committee
to
the
Administrator
of
the
Environmental
Protection
Agency;
Receipt
of
Report
and
Request
for
Comments;
Notice
I
49530
Federal
Register
/Vol.
67,
No.
146
/Tuesday,
July
30.
2002
/Notices
ENVIRONMENTAL
PROTECTtON
AGENCY
[OPPT­
2002­
0026;
FRL­
7183­
71
Fiftieth
Report
of
the
TWA
Interagency
Testing
Committee
to
the
Administrator
of
the
Environmental
Protection
Agency;
Receipt
of
Report
and
Request
for
Comments
AGENCY:
Environmental
Protection
Agenc:
y
(EPA).

ACTION:
Notice.

SUMMARY:
The
Toxic
Substances
Control
Act
(TSCA)
Interagency
Testing
Committee
(ITC)
transmitted
its
50'1'
ITC
Report
to
the
Administrator
of
EPA
on
May
26,
2002.
In
,tht!
50th
ITC
Report,
which
is
included
with
this
notice,
the
ITC
is
rescinding
its
request
in
the
46'"
ITC
Report
to
EPA
for
the
addition
to
the
TSCA
section
8(
a)
Preliminary
Assessment
Information
Reporting
(PAIR)
rule
of
12
of
the
15
Degradation
Effects
Bioconcentration
Information
Testing
Strategies
(DEBITS)
chemicals.
However.
the
ITC
is
asking
EPA
to
add
3
chemicals
to
the
PAIR
r&
and
3
chemicals
to
the
TSIA
section
8ldj
Health
and
Safety
Data
Reporting
'
(HaSDR)
rule.
The
ITC
is
adding
2
chemicals
and
removing
36
chemicals
from
the
Priody
Testing
List.
The
ITC
is
soliciting
comments
017
its
Voluntary
Information
Submissions
Innovative
Online
Network
(VISION)
and
Voluntary
Information
Submissions
Policy
(VISP).

DATES:
Comments,
identified
by
docket
ID
number
OPPT­
2002­
0026,
must
be
received
on
or
before
August
29,
2002.

ADDRESSES:
(:
onmients
may
be
submitted
by
mail,
electronically,
or
in
person.
Please
follow
the
detailed
instructions
for
each
method
as
provided
in
TJnit
I.
01tho
SUPPLEMENTARY
INFORMATION.
To
ensure?
proper
receipt
by
EPA,
it
is
imperative
that
vou
identifv
docket
control
number
t1PP'?­
2002­
0&
6
in
the
subject
line
on
the
first
page
of
your
rcsspo~~
se.

FOR
FURTHER
INFORMATION
CONTACT:
For
general
ir~
fonnatim
conlnct:
Barbara
Cunningham,
Acting
Director,
Environmental
Assistanc:
e
Division
(7408h/
l),
Office
of
Pollution
Prevention
and
Toxics,
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Wzqhington,
DC
20460;
telephone
numbers:
(202)
554­
1404;
e­
mail
address:
TSCA­
Hotline@
epa,
gov.
For
technical
informalion
co~~
tact:
John
D.
Walker,
Il?
Executive
Director
(7401M),
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW,,
Washington,
DC
20460;
telephone
number:
(202)
564­
7526;
fax:
(202)
564­
7528;
e­
mail
address:
~~
alk~!
r.
johnd@
cpa.
gov.

SUPPLEMENTARY
INFORMATION:

I.
General
Information
A.
Does
lhis
Actiiml
Apply
to
Me?

This
notice
is
diroctccl
to
the
public
in
general.
It
may,
however,
be
of
particular
interest
to
you
if
you
manufacture
(defined
hy
statute
to
include
import)
and/
or
process
TSCA­
covered
chemicals
and
you
may
be
identified
by
the
North
American
Industrial
Classification
System
(NAICS)
codes
325
and
32411.
Because
this
notice
is
clirectecl
to
tlif!
general
public
and
other
ent­
ities
may
also
be
interested,
the
Agency
has
not
attempted
to
describe
all
the
specific
entities
that
may
be
interested
in
this
action.
If
you
have
any
questions
regarding
the
applicability
of
this
action
to
a
particular
entity,
consult
the
technical
person
listed
under
FOR
FURTHER
INFORMATION
CONTACT.

B.
How
Can
I
Get
Additional
Informafion,
Including
Copies
of
this
Document
or
Other
Related
Documents?

1.
Ekxtrmicdly.
You
may
obtain
electronic
copies
of
this
document,
and
certain
other
related
documents
that
might
be
available
electronically,
from
the
EPA
Internet
Home
Page
at
http://
www.
epa.
gov/.
To
access
this
doc:
ument,
on
the
Home
Page
snlec:
t
"Laws
and
Regulations,"
"Regulations
and
Proposed
Rules,"
and
then
look
up
the
entry
for
this
document
under
the
"Federal
Register­
Environmental
Documents."
You
can
also
go
directly
to
the
Federal
Register
listings
at
http://
www.
epa.
govlfedrgstr/.
You
mav
also
access
additional
informati&
about
the
ITC
and
the
TSCA
testing
program
through
the
web
site
for
the
Office
of
Prevention,
Pesticides
and
Toxic
Substances
(OPPTS)
at
http://
www.
epa.
gov/
opptsfrs/
home/
opptsim.
htm/,
or
go
directly
to
the
ITC
home
page
at
http:
llwww.
epa.
gov/
opptintr/
itc:/.
2.
In
pylon.
The
Agency
has
established
an
official
record
for
this
action
under
docket
control
number
OPPT­
2002­
0026.
The
official
record
consists
of
the
documents
specifically
referenced
in
this
action,
any
public
comments
received
during
an
applicable
comment
period,
and
other
inrormation
related
to
this
action,
including
any
information
claimed
as
Confidential
Business
Information
(CBI).
This
official
record
includes
the
documents
that
are
physically
located
in
the
docket,
as
well
as
the
documents
that
are
referenced
in
those
documents.
The
public
version
of
2
the
official
record
does
110~
include
any
information
claimed
as
CBI.
The
public
version
of
the
official
record.
which
includes
printed,
paper
versions
of
any
electronic
comments
submitted
during
an
applic:
able
c:
ommont
period,
is
ava%
ble
for
inspection
in
the
TSCA
Nonconfidential
Information
Center.
North
East
Mall
Rrn.
B­
607,
Waterside
Mall,
401
M
St.,
SW.,
Washington,
DC.
The
Center
is
open
from
noon
to
4
pm,,
Monday
through
Friday,
excluding
legal
holidays.
The
telephone
number
for
the
Cenler
is
(202)
260­
7099.

C.
How
and
to
Wlwn
Do
I
Submit
cfm7m
on
ts
I'

You
may
submit
c:
ommonts
through
the
mail,
in
person,
or
electronically.
To
ensure
prop&
receipt
by
EPA,
it
is
imnorativo
that
vou
identifv
docket
co&
o1
number
i)
PPT­
20Oi­
0026
in
the
subject
line
on
the
first
page
or
your
response.
i.
By
nzail.
Submit
your
comments
to:
Document
Control
Of&
e
0407Ml.

Office
of
Pollution
Preven`
tion
a&
Toxics
(OPPT),
Environmenlal
Protection
Agfmcy,
1200
Pennsylvania
Ave.,
NW.,
Washmgton,
DC
20460.
2.
In
person
or
I))/
courier,
Deliver
your
comments
to:
OPPT
Document
Control
Office
(DCO)
in
EPA
East
Building
Rm.
6428,
1201
Constitution
Avo.,
NW,,
Washington,
DC.
The
DC0
is
open
from
a
a.
m.
to
4
p.
m.,
Monday
through
Friday,
excluding
legal
holidays.
The
telephone
number
for
the
DC0
is
(202)
564­
8930.

3.
El:
lectronically.
You
may
submit
your
c:
omments
elec:
tronic:
ally
l­
ty
o­
mail
to:
oppt.
nc:
ic@
epa.
gov,
or
mail
your
computer
disk
to
the
address
identified
above.
Do
not
submit
any
information
elec:
tronic:
allp
that
you
consider
to
be
CBI.
Electronic
comments
must
he
submitted
as
an
ASCII
file
avoiding
the
use
of
special
characters
and
any
form
of
encryption.
Comments
and
data
will
also
be
accepted
OII
standard
disks
in
WordPerfecl6.1/
8.0
or
ASCII
file
formal.
All
comments
in
electronic:
form
must
be
identified
bv
docket
control
d
number
OPPT­
2002­
0026.
Electronic
comments
may
also
he
filed
online
at
many
Federal
Depository
Libraries.

D.
How
Should
I
I­
landlr!
CBI
Informatian
that
I
Want
to
Submit
to
tho
Agel
KY?

Do
not
submit
any
information
electronically
that
you
consider
to
be
CBI.
You
may
claim
information
that
you
submit
to
EPA
in
response
to
this
;iocument
as
CBI
by
ma&
ing
any
part
or
all
of
that
information
as
CBI.
Inl'ormation
so
marked
will
not
be
disclosed
except
in
accordance
wilh
procedures
set
forth
in
40
CFR
part
2.
Federal
Register
/
Vol.
67,
No.
146
f
Tuesday,
July
30,
2002
/Notices
49531
In
addition
to
one
complete
version
of
the
comment
that
includes
any
information
claimed
as
CBI,
a
copy
of
the
comment
that
does
not
contain
the
information
claimed
as
CBI
must
be
submitted
for
inclusion
in
the
public
version
of
the
official
record.
Information
not
marked
confidential
will
be
included
in
the
public
version
of
the
official
record
without
prior
notice.
If
you
have
any
questions
about
CD1
or
the
procedures
for
claiming
CBI,
please
consult
the
technic:
al
persorl
listed
under
FOR
FURTHER
INFORMATION
CONTACT.

E.
Whut
Should
I
Consider
as
I
Prepme
fMy
Comm
cn
ts
for
EPA?

We
invite
you
to
provide
your
views
and
comments
on
the
50'"
1
ITC
Report.
You
may
iind
the
following
suggestions
helpful
for
preparing
your
comments:
1.
Explain
your
views
as
clearly
as
possible.
2.
Describe
any
assumptions
that
you
used.
3.
Provide
copies
of
any
technical
information
and/
or
data
you
used
that
support
your
views.
4.
Provide
specific
examples
to
illustrate
your
concerns.
5.
Offer
alternatives
for
improvement.
1.3.
To
ensure
proper
receipt
by
EPA,
be
sure
to
identify
the
docket
control
number
assigned
,to
this
action
in
the
subject
line
on
the
first
page
of
your
response.
You
may
also
provide
the
name,
date,
and
Eederai
Register
citation.

II.
Background
The
Toxic
Substances
Control
Act
(TSCR)
(15
U.
S.
C.
2601
el
sey.)
authorizes
the
Administrator
of
the
EPA
to
promulgate
regulations
under
TSCA
section
4(
a)
requiring
testing
of
chemicals
and
chemical
groups
in
order
to
develop
data
relevant
to
determining
the
risks
that
such
chemicals
and
chemical
groups
may
present
to
health
or
the
environment.
Section
4(
e)
of
TSCA
established
the
ITC
to
recommend
chemicals
and
chemic:
al
groups
to
the
Administrator
of
the
EPA
for
priority
testing
consideration.
Section
4(
e)
of
TSCA
directs
the
ITC
to
revise
the
TSCA
section
4(
e)
Priority
?"
esting
List
at
least
every
G
months.

A.
The
5O'b
ITC
Report
The
5011'
ITC
Report
was
transmitted
to
EPA's
Administrator
on
May
28,
2002,
and
is
included
in
this
notice.
In
the
SOuz
ITC
Report,
the
ITC:
1.
Resc:
inds
its
renuast
in
the
4W
ITC
Report
to
EPA
l'or
t&
addition
to
the
PAIR
rule
of
12
of
the
15
DEBITS
chemicals.
The
12
DEBITS
chemic:
als
are
3
"chloroalkenes,"
5
"chlorinated
trihalomethyl
pyriclines,"
1
"trihaloethylidene
bisbenzeno"
(benzene,
1,1'­(
2,2,2­
~ic:
llloroethylidcno)
his­,
CAS
No.
2Q71­
Z­
4);
and
3
"trichlorophenyldihyclropyrazols"
(benzamide.
3­
amino­
N­
14.5­
dihvdro+
oxo­
1­(
2,4,
fil~
ichlorophEnyl)­
1~­
pyrazol+
yl]­,
CAS
No.
40567­
18­
8);
3H­
pyrazol­
3­
one,
5­((%&
no­
2­
chlorophenyl)
amino)­
2,4­
dihydro­
2­
(2,4,&
trichlorophenyl)­,
CAS
No.
53411­
33­
Q;
and
bcnzamide,
N­(
4,5­
dihydro­
5­
oxo­
I­(
2,4­
f&
trichlorophenyl)­
1H­
pyrazol­
3­
yl)+
nitro­,
CAS
No.
63134­
25­
8.
The
ITC
is
not
rescinding
its
request
in
the
4iW
ITC
Report
to
add
benzanamine,
3­
chloro­
2,&
dinitro­
N,
N­
dipropyl­+(
trifluoromethyl]­,
US
No.
29091­
20­
l:
SH­
pyrazol­
3­
one,
5­((
2­
chloro­
5­
nitrophenyl)
amino)­
2,4­
dihydro­
2­[
2,4,&
trichlorophenyl)­,
GAS
No.
30707­
68­
7;
and
phenol,
4,4'­[
2,2,2­
lrshloro­
l­
(tri~
uorome~~
yl)
c~
i~
lirleneJl~
is­,
CAS
No.
1478­
61­
1
to
the
PAIR
rule.
2.
Adds
3
chemicals
to
the
PAIR
rule:
1
DEBITS
chemical
Istannane.
dimothylbis[(
1­
ox&
eoder:
yl)~~
xy]­,
CAS
No.
68928­
76­
7)
from
the
491"
Report;
1
DEBITS
chemical
(benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­,
CAS
No.
3278­
89­
5)
and
1­
triazone,
1,3­
diphenyl­,
CAS
No.
13635­
c
from
the
5otll
ITC
Report.
3.
Adds
stannane,
dimr?
Lhylbis[(
1­
~~
xoncocloc:
yl)
ox~~]­,
CRS
No.
68928­
xi­
7;
benzene?
1,3,5­
tribronio­
2­(
2"
proponyfoxy)­,
GAS
No.
3278­
89­
5;
and
1­
triazene,
1,3­
cliphonyl­,
CAS
No.
136
35­
6
to
.the
TSCA
section
8(
d)
HaSDR
rule.
4.
Solicits
comments
on
its
VISION
and
VISP.

B.
Status
of
the
Priority
Testing
List
The
ITC
is
adding
benzene,
1,3,5­
tril)
rorno­
2­(
2­
prolJen~
floxs)­
(CAS
No.
3278­
89­
5)
and
l­
triaztme,
1,3­
diphenyl­
(CAS
No.
136­
35­
6)
to
the
Priolzily
Teslillg
List.
The
ITC
is
removing
acetone,
9
"alkylphenols"
and
"aIkylpheuo1
ethoxylatos"
added
in
the
37'"
ITC
Report,
7
"nonylphonol
ethoxylates"
added
in
the
39th
ITC
Repoil,
4
"alkylphenols"
and
"alkvlnhenol
ethoxvlates"
added
in
the
415'
iTk
Report,
3
a'EBITS
chemicals
added
in
the
46th
ITC
Report,
3
DEBITS
chemicals
(3
"c:
l~
loroalbnes")
added
in
the
471"
ITC
Report,
and
9
DEBITS
chemicals
added
in
the
48'1'
ITC
Report
ii­
om
the
Priority
T~`
sfing
List.
The
current
TSCA
4(
e)
P&
o&
y
Testing
List
as
of
May
2002
can
he
found
in
Table
1
of
the
50th
ITC
Report
which
is
included
in
this
notice.
List
of
Subjects
Environmental
protection,
Chemicals,
Hazardous
substances.

Fiftieth
Report
of
the
TSCA
Interagency
Testing
Commiltee
to
the
Administrator,
U.
S.
Environmental
Proteclion
Agency
Summary
I.
Hackf!
rourrd
11.
TSCi
Section
8
Rqborting
A.
TSCA
Section
8
Reuortinn
Rules
B.
ITC's
Usu
of
TSCA
??
ecti&
8
and
Other
E.
Requests
to
eromulgate
TSCL
Section
s(
a)
PAIR
and
Section
8(
d)
HaSDR
Rules
III.
UC's
Activities
Durint!
this
Ker>
ortinc
Period
(November
2&
l
to
A{
ril
ZO&)
A.
VISION
B.
L­
JmrI'S
IV.
Revisions
to
the
TSCA
Section
4(
e)
Priority
Testing
List
A.
Chemicals
Added
to
the
%or@
Tes!
ing
Lisl
propenyloxv)­.
2.
1­
Triazorle.
1.­
Z­
diuhenvl.
B.
Chemicals
Rkm&
d
I?&
the
Priorit~~
`I'eslirzg
l;
isl
1.
Acnto11e.

2.
Twcznty
alkylphonols
and
alkylPhtmo1
ethoxvtates.
3.
Throo
&BITS
chemicals
from
the
4W
ITC
Report.
4.
Three
DEBITS
chemicals
from
the
47b
1'1%

SUMMABY
III
this
50'"
ITC
Reporrt.
thho
ITC
is
rescindirlg
its
request
to
tht)
EPA
to
add
12
Degradation
Blfects
Biocorlcentration
Information
Tesling
Strategies
(LWUTS]
chemicals
to
the
TSCA
saction
8ial
l'relimin~
y
Assessment
Inforrx&
n
Reporting
(PAIR)
rule
(3
DEBITS
c:
hemicels
frou~
tho
47t"
1
ITC
Report
and
9
DEBITS
chemicals
from
the
48'"
il'C
Report].
However,
the
I'I'C
is
asking
the
&PA
to
add
6
c:
hemic:
als
to
the
PAIR
rule.
3
DEBITS
chemicals
(a­
chloro­
2,
fj­
dinitro­
NtN­
di~
roovl­
4­
ltrifluoromethvlf­
bollzc311Eamin~.
S­
i­
pj&
ol­?­
one:
5­((
2~
cl&
o­
S­
nitroplie~~
yl)
amino)­
2,4­
dihydro­
2­(
z,
4,6­
trichlorr~
pher,
nvl)­;
and
phanot,
4,4'­[
2,2,2­
trifluoro­
1­(
tr~
fluoromethgl)
otl~~~
lidone]
bis­
1,
from
tha
46"
'
ITC
Report,
1
DEBITS
chemical
(stsnnane,
dimt!
thylbis((
l­
oxonc?
odecyl)
oxy]­

),
hm
the
4w
lx
Reporl,
1
LXMTS
3
49532
Federal
Register/
Vol.
67,
No.
146/
Tuesday,
July
30,
2002
/Notices
chemical
(benzene,
1,3,5­
tribromo­
Z­(
2­
pq~
enyloxy)­).
and
from
the
50"
ITC
Report,
l­
triazene,
1,3&
phtmyl.
The
ITC
is
also
asking
the
EPA
to
add
starmane,
climetl~
ylbis
l(
1
­oxoaeodecyl)
ox~]­:
benzene,
1.
X5­
trihromo­
2­(
2propenyloxy)­;
and
l­
triazene,
1,3­
diphrmyl
to
the
TSCA
section
8(
d)
Health
and
Safety
Data
Keporting
(HaSDK)
rule.
The
ITC
is
adding
benzene,
`1,3,5­
Mbrumo­
2­(
2­
prope1~
ylox~)­
and
1­
triazene,
1.3­
diphm$
to
the
Priority
Testing
List.
The
ITC
is
rt?
rnaving
acetone,
9
alkylphenuls
and
alkylphenol
trthoxylates
from
the
:<
F
ITC
Report,
7
noiiylphenol
ethoxylates
li~
m
the
:%+
ITC
Report,
4
alkylphenols
and
alkylphenol
ethoxylates
from
the
41"`:
IX
Report,
3
DEBITS
chemicals
from
the
46P
ITC
Report,
3
DEBITS
chelnicals
from
the
47th
lTC
Kaport,
and
9
DEBITS
chemicals
horn
the
48"
'
ITC
Report
and
horn
the
Sriosity
Testing
List.
The
ITC
is
solicithi::
comments
on
its
Voluntary
information
Submissions
Innovative
Online
Network
(VlSION)
and
Voluntary
Information
Submissions
Policy
(VW).
The
revised
TSCA
section
4(
e)
Priority
`I'csliq
List
follows
as
`Table
1
of
this
appe11dix.

TABLE
I
.­
THE
TSCA
SECTION
4(~)
PRIORW
TESTING
LIST
(MAY
2002)

I­

Report
Date
28
May
1991
31
January
1993
32
May
1993
35
November
1994
37
November
1995
39
November
1996
41
November
1997
42
May
1998
42
May
1998
46
May
2000
47
November
2000
47
November
2000
48
May
2001
48
May
2001
48
May
2001
49
November
2001
50
May
2002
50
May
2002
Chemical
name/
Group
Action
Chemicals
with
Low
Confidence
Reference
Dose
(RfD)
Thiophenol
Designated
13
Chemicals
with
insufficient
dennat
absorption
rate
data
Designated
16
Chemicals
with
insufficient
dermal
absorption
rate
data
Designated
4
Chemicals
with
insufficient
dermal
absorption
rate
data
Designated
6
Alkylphenols
and
alkylphenol
ethoxylates
Recommended
1
Nonylphenol
ethoxytate
Recommended
3
Alkylphenols
and
alkylphenol
ethoxylates
Recommended
3­
Amino&
mercapto­
1,2,4­
triazole
Recommended
Glycoluril
Recommended
8
Nonylphenol
poiyethoxylate
degradation
products
Recommended
37
lndium
compounds
Recommended
Pentachlorothiophenol
Recommended
Phenol,
4,4'­[
2,2,2­
trifluoro­
l­(
trifluoromethyl)
ethylidenejbis­
Recommended
3­
Chloro­
2,6­
dinitro­
N,
N­
dipropyl­
l­(
trifluoromethyi)­
benzeneamine
Recommended
3H­
PyrazolS­
one,
5­[(
2­
chloro­
5­
nitrophenyl)
amino]­
2,4­
dihydro­
2­
Recommended
(2,4,6­
trichlorophenyl)

Stannane,
dimethylbis[(
l­
oxoneodecyl)
oxyJ­
Recommended
Benzene,
1,3.5­
tribromo­
2­(
Z­
propenyloxy)­
Recommended
I­
Triazene,
1,3­
diphenyl
Recommended
1.
Background
httl~:
ll\
Yww.
cpa.
gov/
f~
dr~
s~
after
publication
chemical
groups
(about
1,400
chemicals)
for
The
IX
was
established
by
section
410)
of
TSCA
"to
make
recomrnend~~
tiorls
to
the
Administrator
respecting
the
chemical
substauces
and
mixtures
to
which
the
Administrator
should
give
priority
consideration
for
the
promulgation
of
a
rule
for
testing
under
section
4(
a)....
Al
least
every
six
months
.
.
.
.
lhe
Commitlee
shall
make
such
revisions
Lo
the
Primity
'l?
stil7g
List
as
it
determines
to
be
nocessaq
and
transmit
them
to
the
Administrator
together
with
the
Committee's
rf?
asons
for
the
revisions"
(Public
Law
94­
469,
90
Stat.
2003
el
seg.,
15
IJ.
S.
C.
2601
et
seq.).
Since
its
creation
in
1976,
the
ITC
has
submitted
49
semi­
annual
(May
and
November)
repurts
to
the
EPA
Adiiiiniskator
tralsmilliq
the
Priorify
Test&
List
and
its
ravisions.
IX
Reports
arf?
available
from
the
ITC's
web
site
(http://
www.
epa.
gov/
opptintr/
itc)
within
a
few
daps
of
submissiorr
to
the
Administrutor
and
born
in
the
Federal
Register.
`limo
ITC
meets
monthly
and
produces
its
revisions
to
the
Prior@
Testing
List
with
administrative
and
technical
support.
frum
the
IX
staff
I?%:
members
and
their
I!.
S.
Government
The
5OtrL
UC
Report
marks
a
si@
ficant
milnstone
for
the
i'K.
Since
its
first
meeting
organizations,
and
contract
support
provided
on
February
5,
1977,
the
i'I'C
has
convened
425
meetings,
screened
thoousands
of
by
EPA.
I'l'C
members
and
staff
are
listed
at
chemicals,
and
reviewed
more
than
2,500
the
end
of
this
Report.

organic,
ogano­
metallic,
and
inorganic:
chemicals
to
identify
those
with
suspicions
of
toxicity,
environmental
release,
and
consumer
or
occupational
exposures,
but
few,
if
a&
y
data
(Ref.
14).
111
it's
50
tCepuiZs,
the
IX
has
added
to
the
PrjorilIT
?`
es!.
qq
Lisf
and
recommended
testing
or
information
reporting
for
8
1
individnal
chemicals
and
80
priority
consideration
by
the
EPA
Administrator.
in
response.
the
EPA
has
published
2~
0
Federal
Kegister
notices
and
reviewed
hnndreds
of
test
prolocols
and
ddla
As
of
l'J92.
testing
was
ongoing.
proposed,
under
consideration.
required
or
voluntarily
submissions
end
the
U.
S.
chemical
industry
oonducted
for
85%
of
the
chemicals
and
has
developed
over
1,
CJOO
tests
and
submitted
clm3tical
groups
reconm~
snded
by
the
ITC,
(Ref.
24).
iMany
of
the
data
developed
as
a
result
of
ITC's
recommendations
have
been
more
than
75.000
unpnbiisliad
health
and
incorporated
into
Material
Safety
Data
salety
studies
to
the
WA.

Sheets,
used
by
U.
S.
Government
and
industry
oga&
atioris
lo
develop
hazard
assessments
and
included
in
the
Organization
for
Economic
Cooperation
and
Development
(OECD)
Screening
Information
Data
Sal
(SlIX]
dossiers
(e.
g.,
1001ti~
of
the
__­­­
Federal
Register
/Vol.
67,
No.
146
/Tuesday,
July
30,
ZOO2
/Notices
49533
c:
hemicals
in
phase
I
of
the
OECD
SIDS
prngram
were
reviewed
by
the
IX
Prior
to
preparation
of
SIDS
dossiers),
[Ref.
14).
Wall­
known
oxamplss
of
chemicals
for
which
data
have
been
developed
as
a
result
of
IX
mcornmendaliolIs
include
alkyl
phthaiates,
chlorinated
paraffins
and
hc!
xat:
hlorobu~
adic~
ne
(I&
f,
l),
acrvlamido,
arvl
phosphates,
mathylene
cl&
ids
and
t.&
chloroethane
(Ref.
2),
chlorinated
benzenes
(Refs.
1
and
3),
benzidine­,
o­
dianisidinn­
and
o­
toluidiritr­
based
dyes
(Ref.
4).
I~
henylencdi~~~
hles
(Ref.
5J,
alkyl
tins
and
iluoroalkancs
(Ref.
8).
octylphenol
(Ref.
7),
bisphenol
A
(Ref.
U),
~e~
rabromobisphanol
A
(Ref.
Q),
methyl
tertiary
butyl
other
or
MTBE
(Kef.
lo),
and
brominated
flame
retardants,
including
brominatnd
diphonyl
others
(Ref.
11).

II.
TSCA
Section
8
Reporting
A.
TSCA
Section
8
Reporting
Rules
Following
rocuipt
of
the
ITC's
Report
(and
the
revised
i+
iorit~
Testing
List)
by
,thc
WA
Administrator,
the
EPA's
Office
of
Pollution
Prevention
and
Toxics
(OPPT)
promulgates
TSCA
section
6(
a]
PAIK
and
`L'SCA
section
S(
d)
HaSDK
rules
for
chemicals
added
to
the
Priority
Testing
List.
The
PAIR
rule
requires
producers
and
importers
of
Chemical
Abstract
Service
(CAS)­
1rumberec1
chemiculs
added
to
Ihe
IJriority
`I'cslirzg
List
to
submit
production
and
exposure
reports
under
TSCA
section
8(
a).
The
HaSDR
rulr:
requires
~~
r~
ducers,
importers,
and
processors
0
all
chamicals
(including
those
with
no
CAS
numbers)
added
to
the
Priority
Testing
List
to
submit
unpublished
health
and
safety
studios
under
TSCX
section
R(
d)
that
must
be
in
c;
ompli~
anc;
ct
with
the
revised
HaSDR
rule
(83
FR
15765,
April
1,
lQQfJ)
(FRL­
5750­
4)
codified
at
40
CFR
part
718.
All
submissions
must
be
received
by
the
EPA
within
QO
ds?;
s
of
the
reporting
r&
s
Federal
Register
publication
date.
The
reporting
rules
are
automatically
promulgated
by
OPPT
unless
otherwise
requested
by
the
ITC.
Under
the
ITC's
VISION
and
VISP,
promulgation
of
HaSDK
rules
for
IIIOS~
chemicals
that
are
added
WI
the
l3kiL.
y
Testing
List
has
bwm
delayad
to
allow
voluntary
submission
of
studies
of
specific:
interest
(see
section
1I.
C.
for
further
details
on
VlSlON
and
VlSP).

The
ITC
reviews
the
TSCA
section
8(
a)
PAIR
rule
reports,
TSCA
section
8(
d)
HaSDR
rule
studies
and
other
information
that
beccJInt?
S
availabln
after
the
I'l'C
adds
cl1emicals
lo
the
lJric&
y
l'esljng
Lis!.
Other
information
includes
`TSCA
section
4(
a)
and
4(
d)
studios;
TSCA
section
U(
c)
submissions;
TSCA
section
8(
e)
"substantial
risk"
noticus:
"For
Your
Information"
(FYl)
submissions;
lTC
voluntary
subrnlssions,
unpublished
clata
submitted
to
and
from
U.
S.
Covornment
organizations
represontcct
on
the
ITC;
published
papors,
as
well
as
use.
exposure?
effects,
and
persistence
data
that
arc
voluntarily
submitted
to
the
ITC
by
manufacturers,
Importers,
processors,
and
users
of
chemicals
recommended
by
the
KC.
The
ITC
reviews
this
information
and
doterminus
if
data
needs
should
be
ruvised,
if
chemicals
shonld
he
rumovad
from
the
Priority
Testing
Lisf
,
or
if
recommendations
shnulcl
bt!
changed
io
designations.

C.
Promoting
More
Effi&?
nt
I,&
.of
Irf~
formuliorr
Suhniss~
o~~
Resources
1'0
promote
more
efficient
use
of
information
submission
resources,
the
ITC
developed
the
VlSP
and
VlSION.
The
VISP
provides
examples
of
data
needed
by
IX
member
U.
S.
Government
c)
rganizations,
examples
of
studies
that
should
not
be
submitted,
the
milestones
for
submitting
information,
guidelines
for
using
the
TSCA
Electronic
HaSIlR
Form
and
instructions
for
oladronically
submitting
full
studies.
The
VW
is
&&
bed
in
the
WC's
4l"`
Report
(63
FR
27058,
April
Q,
lQQ8)
(FRL­
5773­
5)
and
is
accessible
through
the
world
wide
web
(httP;/
l~~~~~
w.~
l)
a.
govlopptintr/
itc/
visI~.
htm
).
To
facilitate
the
implementation
of
the
VISP,
the
lTC
developed
the
WSION.
The
VISION
is
described
in
the
lTc's
42""
'
ITC
Report
(63
FR
42554,
August
7,
lYQ8J
(ML­
57Q7­
8)
and
is
also
accessible
through
the
world
wide
web
(httIJ://~~~
w.
c?
pa.
gov/
oIJp~
it~
tr/
ifitc/
visionhtm).
The
WSION
imcludt~
s
links
to
the
`TSCA
Electronic
HaSDR
Form
(http://
~ww.
epa.
govlopptintr/.
er/
hasd.
htni)
including
revised
section
3.2
of
the
TSCA
Bloctronic
HnSDR
Form
ta
provide
mom
use
and
exposure
information
(for
details
see
the
4W
ITC
Report;
85
PR
75552,
Docfxnber
1,
2000)
@x&­
6594­
7).
The
ITC
requests
that
chemical
producers,
importers,
processors,
and
users
provide
information
eler.*
ronically
via
VlSlON
on
chemicals
for
which
the
KC
is
soliciting
voluntary
inform&
m.
If
the
ITC
doos
not
receive
voluntary
information
submissions
to
meet
its
datia
n~
cls
according
to
the
procednros
in
VISP,
tho
ITC
may
than
ask
the
EPA
to
add
those
c:
hamicals
to
a
TSCA
section
U(
d)
HaSLX
rule
to
determine
iftllere
are
unpublished
data
to
ruest
those
nesds
(sot:
section
IIl.
A.
that
requests
commants
on
thtt
need
to
continue
VISION
and
VlSP).

19.
Coordinati~
lg
hformntion
Rrquests
To
avoid
duplicate
reporting,
the
I'I'C
carof~
dilllp
coordinates
its
inforrnatiou
solicitations
and
reporting
ruyuirements
with
other
national
and
international
lusling
programs,
(e.
g.,
the
National
Toxicology
Program,
the
OECD
SIDS
program
aud
the
EPA's
High
Production
Volume
(WV)
Chaliongo
program).
The
IX
is
currcmtiy
focusing
its
efforts
on
persistent
non­
HIT
chemicals
that
have
bioconcentration
and
exposure
potential,
but
few,
if
any.
publicly
available
ocologic:
al
or
health
effoc:
ts
data
The
ITC
is
working
with
the
EPA
Persistent
Bioaccumulativo
Toxics
(PHT),
Endocrine
Disruption,
and
perfluoroctylsulfooaate
chemicals
workgroups
to
identify
potontiallp
toxic
chemicals
with
few
data
to
complement
the
oBjectives
of
those
programs.

B.
Rquluesfs
to
Promulpiu
TSCA
Section
X(
a)
PAIR
und
Section
U{
cI)
HuSDB
B&
s
The
ITC
asked
the
EPA
to
add
3
chloroalkenes
to
tlm
`ISCA
section
8(
a)
PAIR
rule
in
its
4WL
WC
I&
port
(88
IX
51278,
October
5,
2001)
(FRL­
6786­
7).
111
addition,
the
ITC
asked
the
EPA
to
add
5
chlorinated
trihalomethyl
pyridincts,
2
trihaloothylidone
bisbcnzenes,
4
trichloropI~
enyl~~
iihydroI~
yrazoIs,
and
3­
chloro­
X,
8­
dinitro­
N,
N­
dipropyl­
4­
(trifluorornethyl)­
benzeaeaminc?
Ilinf~
to
the
`I'SCA
section
8(
a)
PAlK
rule
in
its
48'11
1'1%
Report
(68
1%
51276,
October
5.
2001).
At
this
time.
the
WC
is
rescinding
its
requosf
to
add
the
3
chloroalkenos;
5
chlorinated
trihalomethyl
pyridines;
1
of
the
trihaloo~
hylidone
bisbenzones
(benzone,
1,1'­
(2,2,2­
trichloroetl~~
lidene)
bis­,
CAS
No.
2971­
22­
4);
and
3
of
the
trichlorophenyldihydropyrazols
(bonzamida,
3­
amiilo­
N­/
4,8­
dil~
ydro­
B­
oxo­
l­
(2,4,
ti­

trichlorophenyl)­
lH­
pyrazol­
3­
yl,
CM
No.
40587­
18­
8.
3H­
pyrazol­
3­
one,
5­((
5­
amino­
2­
c:
hloroyhenyl)
anlino)­
2,4­~~
it~
y~.
o­
2­[
2,4.
ti­
1richlorophenyl)­,
CAS
No.
53411­
33­
y.
and
benzamide,
N.:(
4,8­
rli~~~
drLI­
5­
oxo­
l­(
2,4,8­
trichlorophonyl)­
lH­
pyrazol­:%
yl)+
nitro­.
CAS
No.
03134­
25­
8)
to
the
TSCA
section
8(
a)
PAIR
rule,
either
because
no
production
or
importation
data
were
submitted
to
the
EPA
in
response
to
tho
1998
Inventory
Update
Rule
@JR)
or
because
the
predicted
bioc:
oncentration
factors
(BCPs)
wore
judged
to
be
too
low
to
warrant
priority
consideration
at
this
time.
The
WC
is
not
rescinding
its
request
to
add
3­
chloro­
2,
fj­
dinito­
N,
N­
dipropyl­
4­
(trifluororm~!
thyl)­
beIr~
ene~
Ilinc
(CAS
No.
2QOQl­
20­
l),
3H­
pyrazol­
3­
one,
5­((&
chloro­
5­
nitrophenyl)
amino)­
2,4­
dihydro­
Z­(
2.4,8­
trichlorophenyl)­
(CM
No.
30707­
8%
71,
and
phenol,
4,4'­[
2,2,2­
trifluoro­
1­
(trifluoromctthyl)
ethglidanej~~
is­
(CAS
No.
1478­
81­
l)
to
the
TSCA
section
8(
a)
PAIR
rule.
At
this
time,
the
IX
is
also
asking
the
EPA
to
add
starmane,
dimethylbis[(
l­
oxont:
odecyl]
oxvl­
(CAS
No.
ti892H­­
76­
71,
benzene,
1,3,5­
thbrolno­
2­(
2­
propenyioxy)­
(CAS
No.
3278­
89­
5)
and
I­
Mazene,
1,3­
diphenyl
(CAS
N0.138­
X­
6)
to
the
TSCA
section
B(
a)
PAIR
rule.
Stannane.
dimethylbisl(
2
­oxo~~
eoclec~~
l)
oxy
I­
and
benzene,
1,3,5­
trihromo­
2­(
2­
propenyloxy)­
are
being
added
to
the
TSCA
section
8(
a)
PAIR
rule,
because
they
are
cmtimated
to
persist
and
have
predicted
I­
XX's
of
8,650
and
4,019.
respuclively,
few
toxicity
data
and
a
noocl
for
additional
use
and
exposure
data,
hepond
that
provided
by
the
manufacturers.
I­
Triazene,
1,3­
diphenyl
is
being
added
to
the
TSCA
section
8(
a)
PNK
rule,
becanse
it
is
a
prodictod
carcinogen
based
on
its
metabolism
and
bocauso
the
ITC
needs
occupational
exposure
data.
At
this
time,
the
ITC
is
also
asking
the
EPA
lo
add
stannunc,
climctthylbis[(
l­
oxoneodeoyl)
oxyl­,
benzene,
1,3,%
ribromo­
2­(
2­
propenyloxy)­
and
1­
lriazene,
1,3­
diphenyl
to
the
TSCA
section
8(
d)
HaSDR
rule.
Stannano,
dimothylbis[(
l­
oxont:
odecyl)
oxyj­
is
being
adclad
to
the
TSCA
section
8(
d)
HaSDR
rule,
I~
c;
ause
the
ITC
needs
to
know
if
there
are
other
toxicit)
data
in
addition
to
that
described
in
section
lV.
A.
2.
and
3.
of
the
49'31
Report
(87
FR
10298,
March
8.2002)
(FRL­
8820­
8).
The
ITC
needs
ecological
effects
and
more
health
effects
data;
only
studies
where
starmane,
dil~
lethylbisl(
l­
oxor~
ao~
le~
yl)
r)
xyj­
is
290%
of
Ihe
test
substance
by
weight
should
be
submitted.
Benzene,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
is
being
added
to
the
TSCA
section
8(
d)
HaSDR
rule,
because
the
I'IC
needs
to
know
49534
Federal
Register
/
Vol.
67,
No.
146
/Tuesday,
July
30,
2002
/Notices
if
there
are
other
toxicity
data
in
addition
to
that
described
in
section
iV.
A.
l.
iii.
of
this
Report.
The
ITC
needs
ecological
ef!&
cls
and
more
health
effects
data;
only
studies
whore
benzene,
1,3,5­
tribromo­
2­(
z­
propenyloxp)­
is
ZW%
of
the
test
snbstaace
by
weight
should
be
snhmitted.
1
­Triaxene,
1,3­
diphonyl
is
being
added
to
the
TSCA
section
6(
d)
HaSDK
rule,
because
the
ITC
needs
pllarrrlacokirletics,
genotoxicity,
subchronic
and
chronic
toxioity,
reproductive,
and
developmental
toxicity
data.
Only
studies
where
di~
oanliI~~~
hc,
llzerlg
is
XXJ%
ol
the
lest
substance
by
weight
should
be
submitted.

III.
WC's
Activities
During
this
Reporting
Period
(November
2001
to
April
~002)

A.
V1SK­
h'

The
KC
is
the
only
organization
for
which
the
EPA
cm
promuIgate
dire13
TSCA
suction
8(
d)
HnSDR
final
rules.
As
such,
when
the
EPA
cm~
venod
public
meetings
to
discuss
mvisioris
to
the
TSCA
section
8(
d)
HaSDR
rule
[63
F'K
15765,
April
1,
1998)
(PRL­
5750­
4),
the
KC
was
invited
to
provide
and
respond
to
comments
on
this
rule.
One
of
the
most
consistent
comments
by
the
chemical
industiy
was
that
the
1TC
should
offer
more
opportunities
to
provide
voluntary
information
submissions
[to
avoid
the
mandatory
requirements
of
submitting
inform&
n
in
response
to
a
TSCA
sec:
tion
8(
d)
HaSDR
rule).
In
rasponso
to
these
chemical
industry
requests,
the
ITC
developed
VISI'.
VISION,
and
the
TSCR
Electronic
HaWR
Form.
ar~
l
is
currentl?;
evaluating
their
effecliveness.
`Thu
EC
developed
VISP
,
VISKIN,
and
the
TSCA
Electronic
HaSDR
Form
as
tools
to
provide
a
more
cost­
effective
method
for
chumioal
producers,
importers,
processors,
and
users
of
ARC­
rt?
c~
omulanded
chemicals
to
provide
voluntary
information.
With
the
exception
of
3
trade
organizations,
the
Alkylphenols
(L
Ethoxylates
Research
Council
(APEX),
the
Color
Pigment
Manufacturers
Association
(CPMA),
and
lhe
Ecological
ancl
`f'oxicologicsl
Association
of
Organic:
Dye
Manufacturers
(ETAD),
and
4
manufacturers.
3M
Spoc:
ialty
Materials,
Ciba
Speciality
Chemicals,
B.
I.
du
Pont
de
Nemours
and
Company,
and
Rohm
and
Haas
Compall>
f,
these
tools
have
not
been
used
by
cheinlcal
producers.
importers,
processors,
and
users
of
ITC­
recommended
chemicals.
The
ITC
has
received
voluntacy
information
submissions
on
~15%
of
the
approximately
500
chemicals
for
which
the
lTC
has
solicited
voluntary
information
since
implementing
the
VW
and
VlSION,
in
effect
delapiug
the
l'l'c's
ability
to
obtain
the
information
it
needs
to
make
doc:
isions
and
meet
U.
S.
Government
data
needs.
The
ITC
recognizes
that
there
are
increasing
demands
on
the
c:
homic:
al
industry
to
provide
information
in
response
to
voluntary
initiatives,
e.
g,.
the
OECD
SIDS
program,
EPA
HPV
Challenge
program
and
Voluntary
Children's
Chemical
Evaluation
Program
(VCCEP).
The
ITC
supports
and
coordir&
es
its
voluntary
information
requests
with
these
programs.
Howover,
as
a
statlltorp­
mandatat11
organization
charged
with
screening
and
identifying
potentially
hazardous
chemicals,
the
ITC
also
recogdizes
that
the
chemical
industry
has
the
responsibility
under
TSCA
and
under
the
principles
of
Respomible
Care@
and
Chemical
Right­
to­
Know.
to
promptly
and
voluntarily
provide
information
on
the
ITC's
rt:
commc:
nded
chemicals
to
be
used
in
subsequent
hazard,
exposure,
and
risk
assessments
by
the
U.
S.
Government
organizations
represented
on
the
XC.
The
IX
is
considering
whether
to
continue
he
use
of
the
VISP,
VISWN,
and
the
`1'SCA
JJlectronic
HaSDR
Form
for
chemicals
added
to
the
Priorily
li;
stin,
v
Lid,
as
the
lack
of
use
of
these
tools
has
resulted
in
substantial
delays
in
obtaining
information
thal
could
be
used
to
moat
the
LX's
data
needs,
The
ITC
requests
comments
on
procedures
that
could
be
implemented
to
make
these
existing
tools
or
other
procedures
for
submitting
voluntary
information
more
effective.
Comments
in
a
word
processing
file
attached
to
an
c­
mail
to
walkar.
johrIdQepa.
gov
are
prelerred,
but
the
ITC
will
also
accept
comments
submitted
lo
Dr.
Tohn
LX
Walker
at
the
address
listed
at
the
end
of
this
Report
by
September
30,
2002.

s.
DEBITS
In
its
4+
thrwgh
4@
ITC
Reports3
the
KC
desoribnd
its
strategies
to
scrt~
l
and
twaluxte
chemicals
with
persistence
and
bioconce~
ltratioll
potential.
These
activities
are
referred
to
as
DEBlTS.
LXWTS
provides
a
means
to
prioritize
chemicals
ii>
r
information
reporting
and
testing
based
on
degradation
and
bioconc~
ntration
potential
and
availability
of
efff;
cts
data.
Prior
to
this
reporting
period
the
ITC
made
information
reporting
or
testing
deferral
decisions
on
206
D)
IBI'l'S
chemicals.
During
this
reporting
period,
the
lTC
completed
its
review
of
the
remaining
252
DEBITS
chemicals,
including
the
9
chemicals
discussed
in
this
section:
1.
Benzene,
1,:%
5­
trihromo­
2­(
2­
proponyloxy)­
(CAS
No.
3278­
89­
53,
2.
2,~­
r)
imethylquinataidone
(CAS
No.
YUO­
26­
71,
3.
1,2­
Ethanodiyl
tetrakis
[2­
chloro­
I­
methylethyl)
phosphate
(CAS
No.
34621­
SY­
31,
4
Oxirane
2
2'
2"­

.5.
Fcresol,
2.6­
di­
terl­
butyl­
alpha­
(dimathylamino)
(CAS
No.
88­
27­
7),
6.
Spiro
isobonzoflnan­
l(
3H),
9'­`
i)
H
xanthen+
one,
8'.
8'­
llis(
t?
thylaillino)­
2',
7'­
dimethyl­
(CAS
No.
41382­
37­
O),
7.
lH­
indole­
2­
carboxaldehyde,
2,3­
dihydro­
2­
hydroxy­
1,3,%
trimethgl­(
4­
rnethoxyphcnyl)
methylhydr~
zone
(CAS
No.
61241­
W­
R),
8.
Phsnoxazin­
5­
iurn,
3,7­
bis(
diothylarnirlo)­,
(T­
4)­
tetrachlorozinca~
e(
2~)
(21)
(CAS
No.
63~~.
47­
Y),
and
9.
Oxirane,
2­[
2­(
4­
chloro~~
he1lyl)
otl~
ylj­
2­
(l,
l­
cii~~
letliyletl~~~
i)­
(CAS
No.
80443­
63­
6).
The
lTC
is
adding
benzene,
1,3,5­
trihromo­
2­
12­
propenyloxy)­
to
the
Prjority
Test&
2;
ist
as
discussed
in
section
IV.
A.
1.
The
ITC
deferred
making
a
testing
recommendation
for
2,
s­
flimc~
rt~
ylquinacridone
beoause
its
absorption
potential
into
mammalian
tissues
is
expnbed
to
he
low
based
on
absorption
data
for
the
structurally
related
EPA
HPV
Challenge
chemical,
5,12­
dihydroqnino(
2,3­
b)
acridine­
7,14­
dione
(CAS
No.
1047­
16­
l).
1,2­
Bthancdi~
l
tetrakis
(Z­
chloro­
l­
methylethyl)
phosphate
was
previously
removed
from
the
Prioritv
Tftstining
List
in
the
1Tc's
36l"
ITC
Report
(GO
FR
42982,
August
17,199!
5)
(FlL.
4965­
6).
Oxirane,
2,2',
2"­(
mc?
thylidyI~
etris
(phonyleneoxymeth)
e~
ie))
lris­
was
defelrsd
for
testing
because
its
predicted
hydrolysis
half
life
was
3
days.
The
1TC
deferred
rrraking
testing
recommendations
for
p­
cresol,
2,6­
di­
tert­
buryl­
alpila­(
dimethylainiilo);
Spiro
isobeilzof~
an­
l(
3H).
9'­`
3H
xanthen+
one.
3',
6'­
bis(
ethylamino)­
2',
7'­
dimethyl­:
lH­
indole­
2­
carhoxaldahyde.
2,~
dihyd.
ro­
2­
hydroxy­
l,
3,3­
trimeth~~
l­(
4­
methoxyphenyl)
met~
lylhydrazone:
and
phenoxazin­
5iam,
:~,
7­
his(
diethylamino)­.
(T­
4)­
lotrachlorozi~
icala(
Z­)
(2~
1)
because
of
their
low­
exposure
potential.
Oxirane,
a­
12­(
4­
chlorophc!
nyl)
ethyl]­
2­(
l,
l­
diInetll~/
lethyl)­
was
deferred
for
testing
because
it
is
likelv
to
be
tested
under
one
of
the
voluntary
H@
V
chemical
testing
Programs.
The
remaining
243
DEBITS
chemicals
deferred
for
testing
include
7
DEBrlYS
chemicals
with
predicted
BCFs
<1,000
(see
Table
2
of
this
appendix),
28
EPA
HPV
Challenge
program
DEBl'l'S
chemicals
(see
`Table
3,
of
this
appendix),
and
208
non­
HIJV
DlXBl'I'S
chemic:
als
with
predic:
ted
l3CFs
of
3­
13
[see
Table
4
of
this
appendix).

TABLE
~­­­­
SEVEN
DEBITS
CHEMICALS
WITH
PREDICTED
BCFs
cl
,000
1
CAS
No.
Chemical
name
Structural
class
1
BCF
827­
94­
l
90­
93­
7
2,6­
Dibromo­
Cnitrobenzenamine
Bie[
4­(
Dimethylamino)
phenyl]
methanone
2,6­
Dibromoanilines
64
4,4'­
Substituted
benzophenones
467
I
6408­
72­
6
I
­
9,
lO
Anthracenedione,
1,4­
diamino­
2,3­
diphenoxy­
1
Diaminoanthraquinone
I
585
~~~~
I
CAS
No.
Federal
Register
/
Vol.
67,
No.
146
/Tuestlay,
July
30,
2002
/Notices
TABLE
~.­­­
SEVEN
DEBITS
CHEMICALS
WITH
PREDICTED
BCFs
<I
,OOO­
Continued
Chemical
name
Structural
class
49535
(
BCF
19014­
53­
O
9,10­
Anthracenedione,
l­
amino­
2­(
4­((
hexahydro­
2­
oxo­
IH­
azepin­
I­
yl)
methyl)
phenoxy)­
4­
hydroxy­
Hydroxyamino
anthraquinones
596­
03­
Z
Spiro
isobenzofuran­
1(
3H),
9'­
9Hxanthen­
3­
one,
4,5'­
Spiro[
isobenzofuran­
1(
3H),
Q'­[
9H]
xanthen]­
3­
one.
s
dibromo­
3;,
6'­
dihydroxy­,
disodium
salt
1709
I
2280­
49­
I
N­
Phenyl­
N­(
trichloromethylsulfenyl)
benzene
Slll­

fonamide
/59a­
­1
20941­
65­
5
Tetrakis(
diethyicarbamodithioato­
S,
S')
tellurium
I
I
G
7
TABLE
3.­
TWENTY­
EIGHT
EPA
HPV
CHALLENGE
PROGRAM
DEBITS
CHEMICALS
CAS
No.
Chemical
name
Structural
Class­­[(
2­
Hydroxy­
l­
naphthalenyl)
azo]
benzenesulfonate
salts
7023­
61­
Z
2­
Naphthalenecarboxylic
acid,
4­((
5­
chloro­
4­
methyI­
2­
suifophenyl)
azo)­
3­
hydroxy.,
calcium
salt
(1:
l)

7585­
41­
3
2­
Naphthaienecarboxylic
acid,
4­((
5­
chloro­
4­
methyI­
2­
sulfophenyl)
azo)­
3­
hydroxy~,
barium
salt
(1:
l)

Structural
Class­[[
4­[(
Phenyl)
ato]
phenyl]
azo]
benzenesulfonic
acid
salts
68555­
86­
2
Benzenesulfonic
acid,
4­((
5­
methoxy­
4­((
4­
methoxyphenyl)
azo)­
2­
methylphenyl)
azo)­,
sodium
salt
Structural
Class­
4,4'­
bis(
Triazinylamino)
stilbene­
2,2'­
disulfonic
acid
salts
5182­
81­
9
2,2'­
Stilbenedisulfonic
acid,
4,~­
bis((
rl­
anilino­
6­
morpholino­
s­
triazin­
2­
yi)
amino)­,
disodium
salt
67786­
25­
8
Benzenesulfonic
acid,
22'.(
1
,2­
ethenediyl)
bis(
5­((
4­(
bis(
Z­
hydroxypropyl)
amino)­
6­((
4­
suIfophenyl)
amino)­
1,3,5­
triazin­
Byl)
amino)­,
tetrasodium
salt
Structural
Class
­
4­
Amino­
4'­
nitroazobenzenes
3618­
72­
2
Acetamide,
­(
5­(
bis(
2­(
acetyloxy)
ethyl)
amino)­
2­((
2­
bromo~,
6­
dinitrophenyf)
azo)­
4~
methoxyphenyl)­

Structural
Class­
Halogenated
cycloalkenes
77­
47­
4
l,
3­
Cyclopentadiene,
1,2,3,4,5,5Hexachloro­

3734­­
18­
3
4,7­
Methanaindene,
4,5,6,7,8,8­
hexachloro­
delta(
sup
I$)­
tetrahydro­
(chlordene)

62111­
47­
I
Heptachlorocyclopentene
Structural
Class­
Halogenated
propanes
1070­
78­
6
1
,I
,I
,3­
Tetrachioropropane
16714­
68­
4
1
,I
,2,2,3­
Pentachloropropane
Structural
Class
­Hexachforobicycto[
2.2.
l]
hept­
5­
ene­
2,3­
dicarboxy
compounds
115­
27­
5
4,7­
Methanoiosobenzofuran­
1
,bdione,
4,5,6,7,8,8­
hexachloro­
3a,
4,7,7a­
tetrahydro
II
5­
28­
6
Chlorendic
acid
Structural
Class­
Phosphoric
acid,
2­
chloroethyl
esters
13674­
87­
8
P­
Propanol,
I
,3­
dichloro­,
phosphate
(3:
l)

13204­
14­
8
2,2­
Bis(
chloromethyl)
trimethylene
bis(
bis(
2­
chloroethyl)
phosphate)

Structural
Class
­Suffonaphthyl­
substituted
4,1­
diazophenyl
compounds
8003­
69­
8
1670­
62­
6
Z­
Naphthalenesulfonic
acid,
6­((
7­
amino­
l­
hydroxy­
3­
sulfo­
2­
naphthalenyl)
azo)­
3­((
4­((
4­
amin~
6(
or
7)­
sulfo­
l­
naphthalenyl)
azo)
phenyl)
azo)­
4­
hydroxy­,
trisodium
salt
Trisodium
6­((
2,4­
diaminophenyl)
azo)­
3­((
4­((
4­((
7­((
2,4­
diaminophenyl)
azo)­
I­
hydroxy­
3­
sulphonato­
2­
naphthyl)
azo)
phenyl)
amino)­
3­
suIphonatophenyl)
azo)~­
hydroxynaphthalene­
2­
suIphonate
7
I
­­­.
49536
Federal
Register
/Vol.
67,
No.
146
/Tuesday,
July
30,
2002
/Notices
TABLE
3.­
TWENTY­
EIGHT
EPA
HPV
CHALLENGE
PROGRAM
DEBJTS
CHEMICALS­
continued
CAS
No.
Chemical
name
Structural
Class­
Tetrachlorobenzenes
95­
94­
3
1,2,4,5­
Tetrachlorobenzene
634­
66­
2
I
,2,3,4­
tetrachlorobenzene
Structural
Class
­Tris(
aminoaryl)
methanamimnium
compounds
2152­
64­
9
Benzenamine,
­phenyl­
4­((
4­(
phenylamino)
phenyl)(
4­(
phenylimino)­
2,5­
cyclohexadien­
l­
ylidene)
methyl)­,
monohydrochloride
101­
20­
2
Urea,
N­(
4­
Chlorophenyl)­
N'­(
3,4­
dichlorophenyl)­

719­
32­
4
Terephthaloyl
chloride,
tetrachloro­

433­
06­
3
1,1,2,2­
Tetrachloroethylsulfenyl
chloride
1203­
86­
7
2,2­
Dichloro­
I­(
2,4,5­
trichlorophenyl)­
ethanone
55954­
l
93
IH­
Atepine­
I­
carboxamide,
N­(
3­(((
hexahydro­
2­
oxo­
lH­
azepin­
l­
yl)
carbonyl)
amino)
methyl)­
3,5,5­
trimethylcyclohexyl)
hexahydro­
2­
oxo­

60825­
27­
6
Acetic
acid,
((
3,5,6­
trichloro­
2­
pyridinyl)
oxy)­,
ethyl
ester
64667­
33­
O
Hexanoic
acid,
4,6,6,6­
tetrachloro­
3,3­
dimethyl­,
methyl
ester
6980640­
2
Propanoic
acid,
2­(
4­((
3­
chloro­
5­(
trifluoromethyl)­
2­
pyridinyl)
oxy)
phenoxy)­,
methyl
ester
TABLE
4.­
Two
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITH
PREDICTED
BCFs
OF
3­
13
CAS
No.
Chemical
name
Structual
Class­(
2­
Thiazolylazo)
benzenamines
19745­
44­
9
Propionitrile,
3­[
p­
j(
5­
nitro­
2­
thiazolyl)
azo]­
N­
phenethylanilino]­

68516­
81­
4
Ethanol,
2­[
ethyl[
3­
methyl­
4­[(
5­
nitro­
2­
thiazolyi)
azojphenyl]
aminoJ­

70693­
63­
g
Benzenamine,
N,
N­
diethyf­
3­
methyl­
4­(
2­
thiazolylazo)­

Structual
Class­[(
BHydroxy­
l­
naphthalenyl)
azo]
benzenesulfonate
salts
12688­
94­
7
Manganese,
(4­((
5­
chloro­
4­
methyl­
2­
sulfophenyl)
azo)­
3­
hydroxy­
2­
naphthalenecarboxylato(
2­))­

5070­
41­
8
2­
Naphthalenecarboxylic
acid,
4­((
5­
chloro­
4­
methyI­
2­
sulfophenyl)
azo)­
3­
hydroxy­,
strontium
salt
(1
:I)

17852­
99­
2
Calcium
4­((
4­
chloro­
5­
methyl­
Z­
suIphonatophenyl)
azo)­
3­
hydroxy­
2­
naphthoate
20514­
68­
I
2­
Naphthalenecarboxylic
acid,
4­((
4­
chloro­
5­
ethyl­
2­
suIfophenyl)
azo)­
3­
hydroxy­,
calcium
salt
(1:
1)

67801­
01­
8
Barium
bis(
5­
chloro­
4­
ethyl­
2­((
2­
hydroxy­
l­
naphthyl)
azo)
benzenesulphonate)

67828­
72­
2
2­
Naphthalenecarboxylic
acid,
4­((
4­
chforo­
5­
methyI­
2­
sulfophenyl)
azo)­
3­
hydroxy­,
strontium
salt
(1~
1)

Structual
Class­[(
3,5­
Dinitro­
2­
thienyl)
azo]
anilines
14932­
34­
9
2,2'­(
4­((
3,5­
Dinitro­
Z­
thienyl)
azo)­
4,1­
phenyleneimino)
bisethanol,
diacetate
(ester)

58979­
46­
7
Acetamide,
N­[
5­(
diethylamino)­
2­[(
3,5­
dinitro­
2­
thienyl)
azo]
phenyl]­

Structual
Class­[[
3­[(
Phenyl)
azo]
phenyl]
azo]
benzenes
4482­
25­
l
1,3­
Benzenediamine,
4,4'­(
4­
methyl­
1.3.
phenylene)
bis(
azo)
bis
6­
methyl­

5421­
m­
9
1,3­
Benzenediamine,
4,4'­((
4­
methyl­
1.3­
phenyfene)
bis(
azo))
bis(
6­
methyI­,
dihydrochloride
67874­
26­
4
Benzoic
acid,
~((
4­((
3­((
3­((
2,4­
diaminophenyl)
azo)­
2­
hydroxy­
5­
sulfophenyl)
azo)­
2,~
dihydroxyphenyl)
azo)
phenyl)
azo)­
2­
hydroxy­,
disodium
salt
71799­
74­
1
2,7­
Naphthalenedisulfonic
acid,
4­((
2,4­
dihydroxy­
5­((
2­
hydroxy­
3,5­
dinitrophenyl)
azo)­
3((
4­
nitrophenyl)
azo)
phenyl)
azo)­%
hydroxy­
Federal
Register/
Vol.
67,
No.
146
/Tuesday,
July
30,
2002
/Notices
49537
TABLE
4.­
Two
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITH
PREDICTED
BCFs
OF
3­
13­
Continued
CAS
No.
Chemical
name
Structual
Class­­
j[
4­[(
Phenyl)
azo]
phenyl]
azo]
benzenesulfonic
acid
salts
51418­
90­
7
Benzenesulfonic
acid,
3­((
4­((
4­(
2­
hydroxybutoxy)­
3­
methylphenyl)
azo)­
3­
methoxyphenyl)
azo)­,
monosodium
salt
61290­
31­
I
Benzenesulfonic
acid,
3­((
4­((
4­(
2­
hydroxybutoxy)
phenyl)
azo)­
5­
methoxy­
Z­
methylphenyl)
azo)­,
monolithium
salt
63405­
85­
6
Benzenesulfonic
acid,
3­[[
3­
methoxy­
4­[(
4­
methoxyphenyl)
azo]
phenyl]
azo]­,
sodium
68400­
34­
o
Benzenesulfonic
acid,
4­[[
4­[(
4­
hydroxyphenyl)
azo]­
5­
methoxy­
2­
methylphenyl]
azo­,
monosodium
salt]

68959­
01­
3
Benzenesulfonic
acid,
4­
chloro­
3­((
4­((
4­
ethoxyphenyl)
azo)
phenyl)
azo)­,
sodium
salt
Structual
Class­[[
4­[(
Phenyl)
azo]
phenyfJazo]
benzenesulfonic
acids
30282­
44­
l
Benzenesulfonic
acid,
p­[[
2,4­
dihyroxy­
3­(
xylylazo)
phneyl)
azo]­

Structoal
Class­[
2­
Methoxy­
4­[(
3­
suIfophenyl)
azo)
phenyl]
urea
salts
7246­
45­
5
Benzoic
acid,
2­
hydroxy­
5­((
4­((((
2­
methoxy­
4­((
3­
sulfophenyl)
azo)
phenyl)
amino)
carbonyl)
amino)
phenyI)
azo)­,
disodium
salt
10114­
86­
0
3,3'­(
Carbonylbis(
imino(
3­
methoxy­
4,
l­
phenylene)
azo))
bis(
benzenesulfonic
acid),
disodium
salt
Structual
Class­[
2­
Methoxy­
4­[(
3­
sulfophenyl)
azo]
pheny~]
ureas
8697­
36­
6
Benzenesulfonic
acid,
3,3'­(
carbonylbis(
imino(
3­
methoxy­
4,1­
phenyiene)
azo))
bis­

Structual
Class­
I­[(
Dinitrophenyl)
azo]­
2­
naphthalenols
4998­
82­
7
1­[(
2­
Hydroxy­
3,5­
dinitrophenyl)
azo]­
2­
hydroxynaphthaiene
Structual
Class­
1
H­
lndole­
B­
sulfonic
acid,
2­
phenyf­
3­[[
2­(
phenylsulfonyl)
phenyl]
azo]­
1
H­
Indole­
sulfonic
acid
salts
90677X3­
7
It­
i­
Indole­
sulfonic
acid,
2­
phenyl­
3­[(
2­(
phenylsulfonyl)
phenyl]
azo]­,
monosodium
salt
Structual
Class­
IH­
lndole­
5­
sulfonic
acid,
2­
phenyl­
3­[~
2­(
phenylsulfonyf)
phenyl]
azo]­
IH­
lndole­
5­
sulfonic
acids
93972­
88­
4
IH­
lndole+
sulfonic
acid,
2­
phenyl­
3­[[
2­(
phenylsulfonyl)
phenyl]
azo]­

Structual
Class­
2­(
Phenylazo)­
3­
oxo­
N­
phenylbutanamides
2512­
29­
O
Butanamide,
2­[(
4­
methyl­
2­
nitrophenyl)
azo]­
3­
oxo­
N­
phenyl­

6486­
21­
2
Acetoacetanilide,
2­[(
4­
methoxy­
2­
nitrophenyl)
azo]­

6466­
23­
3
Butanamide,
2[(
4­
chloro­
2­
nitrophenyl)
azo]­
N­(
2­
chlorophenyl)
S­
oxo­

12225­
l
6­
2
Butanamide,
N­(
4­
chloro9,5­
dimethoxyphenyl)­
2­((
2,5­
dimethoxy4­((
phenylamino)
sulfonyl)
phenyi)
azo)­
3­
oxo­

13515­
40­
7
o­
Acetoacetanisidide,
2­[(
4­
chloro­
2­
nitrophenyl)
azo]­

32432­
45­
4
o­
Acetoacetotoluidide,
4'­
chloro­
2­[(
4­
chloro­
2­
nitrophenyl)
azo]­

52320­
66­
8
2­((
4­
Chloro­
2­
nitrophenyl)
azo)­
N­(
4­
ethoxyphenyl)­
3­
oxobutyramide
Structual
Class­
2.4­
bis[(
Arylazo)
arylamino]­&
amino­
1,3,5­
triazines
104­
03­
8
2­
Naphthalenesulfonic
acid,
7,7'­((
6­(
4­
morpholinyl)­
l,
3,5­
triazine­
2,4­
diyl)
diimino)
bis(
4­
hydroxy­
3­((
4­
methoxy­
2­
sulfophenyl)
azo)­,
tetrasodium
salt
50925+
2­
3
1,5­
Naphthalenedisulfonic
acid,
3,3'­((
6­((
2­
hydroxyethyl)
amino)­
l,
3,5­
triazine­
2.4­
diyl)
bis(
imino(
2­
methyl­
4~
1­
phenylene)
azo))
bis­,
tetrasodium
salt
52953­
36­
3
Cuprate(
4­),(
4­
hydroxy­
7­((
4­((
2­
hydroxyethyl)
amino)­
6­((
5­
hydroxy­
6­((
2­
hydroxy­
5­
sulfophenyl)
azo)­
7­
sulfo­
2­
naphthalenyl)
amino)­
1
,3,5­
triazin­
2­
yl)
amino)­
3­((
4­
methoxy­
2­
sulfophenyl)
azo)­
2­
naphthalenesulfonato(
6­))­,
tetrasodium
Struck&
Class­
2­[[
6­[(
1,3,5­
Triazin­
2­
yl)
amino]­
l­
hydroxy­
3­
suIfo­
2­
naphthalenyl]
azo]­
1
,5naphthalenedisulfonic
acid
salts
70616­
90­
Q
I
,5­
Naphthafenedisulfonic
acid,
2­((
6((
4,6­
dichloro­
1
,3,5­
triadn­
2­
yl)
methylamino)­
l­
hydroxy­
3­
sulfo­
2­
naphthalenyl)
azo)­,
trisodium
salt
4953%
Federal
Register
/
Vol.
67,
No.
146
/Tuesday,
July
30,
2002
/Notices
TABLE
4.­
Two
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITH
PREDICTED
BCFs
OF
3­
13­
Continued
CAS
No.
Chemical
name
8992344­
4
Trisodium
2­((
6­((
4­(
ethylphenylamino­
6­
fluoro­
l,
3,5­
triazin­
2­
yl)
amino)­
l­
hydroxy­
3­
sulphonato­
Z­
naphthyl)
azo)
naphthaiene­
1
,LGdisulphonate
12236­
62­
3
68134­
22­
5
Structual
Class­
2­
Azo­
N­(
2,3­
dihydro­
2­
oxo­
lH­
benzimidazol­
5­
yl)­
3­
oxobutanamides
Butanamide,
2­((
4­
chloro­
Znitrophenyl)
azo)­
N­(
2,3­
dihydro­
2­
oxo­
l
H­
benzimidazol+
yl)­
3­
oxo­

Butanamide,
­(
2,3­
dihydro­
2­
oxo­
1H­
bentimidazol­
5­
yO­
3­
oxo­
2­((
2­(
ttif~
uoromethyl)
phenyl)
azo)­

Structual
Class­
2­
Halo%(
phenylazo)­
G
[(((
sulfonaphthyi)
azo)
sulfophenyl)
aminoJ­
i,
3,
btriazines
68110­
31­
6
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
3,6­
bis((
4­((
4­
chloro­
6­((
3­
sulfophenyl)
amino)­
l
,3,5­
triazin­
2­
yl)
amino)­
Z­
sulfophenyl)
azo)
d­
hydroxy­,
hexasodium
salt
66133­
244
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
3,6­
bis[~
5­[[
4­
chloro­
8­[(
3­
sulfophenyi)
amino]­
l
,3,5­
tnazin­
2­
yl]
amino]­
2sulfophenyl]
azo]­
5­
hydroxy­,
hexasodium
salt
70528­
69­
l
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
6­((
5­((
4­((
3­
chlorophenyl)
amino)­
6­~
uoro­
l,
3,5­
triazin­
2­
yl)
amino)­
2­
sulfophenyl)
azo)­
5­
hydroxy­
3­((
4­
sulfophenvl)
azo)­,
tetrasodium
salt
Structual
Class­
3­[[
4­[(
6­
Nitro­
2­
benzothiazolyl)
azo]
phenyl]
amino]
propanenitriles
13486­
43­
6
Ethanol,
2­
ethyl­
4­(
6­
methoxy­
2­
benzothiazolvhazo
phenvl
amino­

16586­
42­
8
Propanenitrile,
3­
ethyl­
3­
methyl­
4­(
6­
nitro­
2­
benzothiazolyl)
azo
phenyl
amino­

16588­
67­
3
Propionitrile,
3­
N­
ethyl­
4­
6­(
methylsulfonyl)­
2­
benzothiazolyl
azo­,
m­
toluidino­

25510­
81­
o
Propanenitrile,
3­(
ethyl(
4­((
6­
nitro­
2­
benzothiazolyl)
azo)
phenyl)
amino)­

41362­
82­
7
Propanenitrile,
3­
4­(
5,8­
dichloro­
2­
benzothiazolyl)
azo
phenyl
methylamino­

Structual
Class­
3­[[
4­((
Phenyl)
azo]­
l­
naphthalenyl]
azo]
benzenesulfonic
acids,
sodium
salts
67875­
21­
2
Benzenesulfonic
acid,
3­
f[
4­
j(
2­
hydroxy­
5­
methylphenyl)
azoJ­
1­
naphthalenyl]
azo]­,
monosodium
salt
68959­
00­
2
Benzenesulfonic
acid,
3­((
4­((
2­
ethoxy­
5­
methylphenyl)
azo)­
l­
naphthalenyl)
azo)­,
sodium
salt
Structual
Class­
3­[[
Phenyl]
azo]­
N­(
phenyl)
benzenecarboxamides
12236­
64­
5
2­
Naphthalenecarboxamide,
­(
4­(
acetylamino)
phenyl)­
4­((!%(
aminocarbonyi)­
2­
chlorophenyl)
azo)­
3­
hydroxy­

36988­
27­
l
2­
Naphthalenecarboxamide,
4­[[
4­(
aminocarbonyl)
pohenyl]
azo]­
3­
hydroxy­
N­(
2­
methoxyphenyl)­

19904­
524
I
­
2
Naphthatenecarboxamide,
3­
hydroxy­
4­((
2­
methoxy­
5­((
phenylamino)~~
onyl)
phenyl)
azo)­

Structual
Glass­
4,4'­
bis(
Arylazo)
stilbene­
2,2'­
disulfonic
acid
salts
2870­
32­
6
2,2'­(
1,2­
Ethenediyl)
bis(
S­((
4­
ethoxyphenyl)
azo)
benzenesulfonic
acid),
disodium
salt
53523­
90­
3
)
Benzoic
acid,
3,3'­[
1,2­
ethenediylbis[(
3­
sulfo­
4,1­
phenylene)
azo]]
bis
[6­
hydroxy­
5­
methyl­,
tetralithium
salt
75701­
34­
7
2­
Naphthatenesulfonic
acid,
3,3'­(
2,2­
ethenediylbis[(
3­
sulfo­
4,1­
phenylene)
azo]]
bis[
6­
amino­
4­
hydroxy­.
cmpd
with
2,2',
2"­
nitrilofris
(ethanol)
(1:
4)

91­
34­
9
37138­
26­
4
41098­
56­
O
17506­
54­
5
68003­
30­
5
Structual
Class4,4'­
bis(
Arylazo)
stilbene­
2,2'­
disulfonic
acids
Benzenesulfonic
acid,
2,2'­(
1,2­
ethenediyl)
bis
5­(
4­
hydroxyphenyl)
azo­

Structual
Class4,4'­
bis(
Triazinylamino)
stilbene­
2,2'­
disulfonic
acid
salts
Benzenesulfonic
acld.
2,2'­(
1,2­
ethenediyl)
bis[
5­[[
4­
chloro­
6­[(
4­
sulfophenyl)
amino]­
1,3,5­
triazin­
2­
yl]
amino]­,
tetrasodium
salt
1,4­
Benzenedisulfonic
acid,
2,2'­(
1,2­
ethenediylbis((
3­
sulfo­
4,1­
phenylene)
imino(
6­(
diethylamino)­
l,
3,5­
triazine­
4,2­
diyl)
imino))
bis­,
hexasodium
salt
Benzenesulfonic
acid,
2,2'­(
1,2­
ethenediyl)
bis(
5­((
4­(
bis(
2­
hydroxypropyl)
amino)­
6­((
4­
sulfophenyl)
am~
no)­
1,3,5­
triazin­
Z­
yl)
amino)­,
dipotassium
disodium
salt
Benzenesulfonic
acid,
2,2'­(
1,2­
ethenediyl)
bis(
5­((
4­(
2­
hydroxypropoxy)­
6­(
phenyiamino)­
l,
3,5­
triazin­
2­
yl)
amino)­,
disodium
salt
Federal
Register
/Vol.
67,
No.
14R
/Tuesday,
July
30,
2002
/Notices
49539
TABLE
4.­
Two
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITH
PREDICTED
BCFs
OF
3­
13­
Continued
I
CAS
No.
I
Chemical
name
~~
~­­
I
68003­
31­
6
Benzenesulfonic
acid,
2,2'­(
1
,2­
ethenediyl)
bis[
5­[[
4­[
2­(
2­
hydroxyethoxy)
ethoxy]­
6­[
phenylamino]­
l
,3,5­
triazin­
2­
yi]
aminoJ­,
disodium
salt
68025­
20­
7
Benzenesulfonic
acid,%((
4­(
2­(
2­
hydroxyethoxy)
ethoxy)­
6­(
phenylamino)­
l,
3,5­
triazin­
2­
yl)
amino)­
2­(
2­(
4­((
4­
(2­
hydroxypropoxy)­
6­(
phenylamino)­
I
,3,5­
triazin­
2­
yl)
amino)­
2­
sulfopheny~)
ethenyl)­,
disodium
salt
68155­
68­
O
Benzenesulfonic
acid,
2,2'­(
1
,2­
ethenediyl)
bis(
5­((
4­
chloro­
6­((
4­
sulfophenyi)
amino)­
l
,3,5­
triazin­
2­
yl)
amino)­,
dipotassium
disodium
salt
85187­
74­
2
Benzenesulfonic
acid,
2,2'­(
1,2­
ethenediyl)
bis@((
4­(
methylamino)­
6­
(phenylamino)­
l,
3,5­
triazin­
2­
yl)
amino)­,
sodium
salt
I
I
Structual
Class­
4­
Amino­
4'­
nitroazobenzenes
101­
52­
o
2­
Methoxy­+[(
4­
nitrophenyl)
azo]
benzenamine
1
1533­
76­
2
/
Propanamide,
­(
5­(
bis(
2­(
acetyioxy)
ethyl)
amino)­
2­((
4­
nitrophenyl)
azo)
phenyl)­

I
1533­
77­
3
Acetanilide,
5'­(
bis(
2­
hydroxyethyl)
amino)­
2'­((
2­
methoxy­
4­
nitrophenvl)
azo)­.
diacetate
(ester)

]
1533­
78­
4
)
Acetamide,
­(
5­(
bis(
2­(
acetyloxy)
ethyl)
amino)­
2­((
2­
chioro­
4­
nitrophenyi)
azo)
phenyl)­

2872­
52­
8
3025­
41­
O
2­(
Ethyl(
4­((
4­
nitrophenyl)
azo)
phenyi)
amino)
ethanol
Ethanol,
2,2'­
4­(
2­
chloro­
4­
nitrophenyl)
azo
phenyl
imino
bis­

3179­
89­
3
Ethanol,
2,2'­
3­
methyl­
4­(
4­
nitrophenyl)
azo
phenyl
imino
bis­

3180­
81­
2
Ethanol,
2­,
4­(
2­
chIoro+
nitrophenyl)
azo
phenyl
ethylamino­

3618­
73­
3
Acetamide,
­(
S­(
bis(
2­(
acetyloxy)
ethyl)
amino)­
2­((
2­
ch~
oro­
4,6­
dinitrophenyl)
azo)­
4­
me~
oxyphenyl)­

1
4058­
30­
4
1
Propanenitrile,
3,3'­((
4­((
2­
chloro­
4­
nitrophenyl)
azo)
phenyl)
imino)
bis­

5261­
31­
4
6021­
61­
o
Propanenitrile,
3­((
2­(
acetyloxy)
ethyl){
4­((
2,6­
dichtoro­
4­
nitrophenyl)
azo)
phenyl)
amino)­

Propionitrile,
3­[
p­[(
2­
chloro­
4­
nitrophenyl)
azo]­
N­(
2­
hydroxyethyl)
anilino]­,

6657­
32­
5
Propionitrile,
3­[
N­(
2­
hydroxyethyt)­
p­
I(
p­
nitrophenyl)
azoJaniiino]­

13301­
61­
6
Propionitrile,
3­[
p­
f(
2,6­
dichloro­
4­
nitrophenyl)
azo]­
N­
ethylanilino]­

1
16586­
43­
9
Propanenitrile,
3­[~
4­[(
2­
chloro­
4­
nitrophenyl)
azo]­
3­
methylphenyl]
ethyfamino]­

5474­
89­
3
Benzonitrile,
Z­[[
p­[(
Z­
cyanoethyl)
ethylamino]
phenyl]
azo]­
5­
nitro­

17464­
91­
4
Ethanol,
2,2'­((
4­((
2­
bromo­
6­
chloro­
4­
nitrophenyl)
azo)­
3­
ch~
orophenyl)
imino)
bis­

17741­
62­
7
Thiomorpholine,
4­
p­(
2,6­
dichloro­
4­
nitrophenyl)
azo
phenyl­,
l,
I­
dioxide
22578­
86­
5
Acetamide,
N­(
2­((
2­
bromo­
4,6­
dinitrophenyl)
azo)­
5­((
2­
cyanoethyl)
ethylamino)­
4­
methoxyphenyl)­

23355­
64­
8
Ethanol,
2,2'­[[
3­
chloro­
4­[(
2,6­
dichloro­
4­
nitrophenyl)
azo]
phenyl]
imino]
di­

24170­
60­
3
Acetamide,
N­
2­(
2­
cyano­
4,6­
dinitrophenyl)
azo­
5­(
diethylamino)
phenyl­

29426­
52­
6
29649­
47­
e
Ethanol,
2,2'­
3­
methyl­
4­
2­(
methylsulfonyl)­
4­
nitrophenyl
azo
phenyl
imino
bis­,
diacetate
ester
Acetamide,­(
2­((
2­
chloro­
4­
nitrophenyl)
azo)­
5­((
2­(
2,5­
dioxo­
1­
pyrrolidinyl)
ethyl)
ethylamino)
phenyl)­

I
10177­
47­
6
1
Benzamide,
N­
5­
bis
2­(
acetyloxy)
ethyl
amino­
2­(
4­
nitrophenyl)
azo
phenyl­
I
30124­
94­
8
Benzonitrile,
2­
4­
bis
2­(
acetyloxy)
ethyl
amino
phenyl
azod­
nitro­

31464­
38­
7
Propanenitrile,
3­
methyl&(
4­
nitrophenyl)
azo
phenyl
amino­

I
31482­
56­
l
Propanenitrile,
3­
ethyC4­(
4­
nitrophenyl)
azo
phenyl
amino­
I
40690­
S­
9
40880­
51­
I
Propanenitrile,
3­[[
2­(
benzoyloxy)
ethyl][
4­[(
4­
nitrophenyl)
azo]
phenylJamino~

Propanenitrile,
3­
4­(
Z­
chloro+
nitrophenyl)
azo
phenyl
ethylamino­

I
41642­
51­
7
Acetamide,
­2­(
2,6­
dicyano­
4­
nitrophenyl)
azo­
5­(
diethyfamino)
phenyl­
I
49540
Federal
Register
/
Vol.
67,
No.
146
/Tuesday,
July
30,
2002
/Notices
TABLE
4.­
Two
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITH
PREDICTED
BCFs
OF
3­
13­
Continued
CAS
No.
I
Chemical
name
43047­
20­
J
52697­
38­
8
53950­
33­
7
56548­
64­
2
61355­
92­
8
22487049
65916­
12­
3
66214­
54­
8
66882­
l
64
67674­
22­
O
67846­
62­
Z
67874­
57­
q
67923434
68391­
42­
4
68391­
47­
9
68957­
67­
5
70210­
10­
5
71617­
28­
2
72968­
78­
6
75150­
12­
7
67875­
18­
7
67875­
11­
O
67875­
14­
3
68039­
07­
6
68039­
08­
7
4399­
55­
7
68227­
72­
5
70210­
31­
O
530­
08­
7
1593­
37­
I
Ethanol,
2,2­
chloro­
4­(
4­
nitrophenyl)
azo
phenyl
amino­

A&
amide,
­[
2­[{
2­
bromo­
4,6­
dinitrophenyl)
azo]­
5­(
diethylamino)
phenyl]­

Acetamide.
­(
2­((
2­
bromo­
4,6­
dinitrophenyl)
azo)­
5­((
2­
cyanoethyl)
amino)­
4­
methoxyphenyl)­

Acetamide,
­[
2­[(
2­
bromo­
4,6­
dinittophenyl)
azo]­
5­(
diethytamino)~­
methoxyphenyl)­

.beta.­
Alanine,
­
3­(
acetylamino)­
4­
(Cnitrophenyl)
azo
phenyl
­N­(
3­
methoxy­
3­
oxopropyl)­,
methyl
ester
Ethanol,
2,2'­
4­(
2,6­
dichloro­
4­
nitrophenyl)
azo
phenyl
imino
bis­

Acetamide.
­(
2­((
2,6­
dicyano­
4­
nitrophenyl)
azo)­
5­((
2­(
2­
ethoxyethoxy)
ethyl)
ethylamino)
phenyl)­

Ethanol,
2,2'­
4.(
4­
nitrophenyI)
azo
phenyl
imino
bis­,
diacetate
(ester)

Benzonitrile,
2­[[
4­[
bis[
2­(
acetyloxy)
ethyl]
amino]­
2­
methylphenyl]
azo]­
5­
nitro­

Acetamide,
­2­(
2­
btomo­
4,6­
dinitrophenyl)
azo­
5­(
ethyiamino)­
4­
me~
hoxyphenyl­

Propanamide,
­(
2­((
2­
chloro­
4,6­
dinitrophenyl)
azo)­
5­(
ethylamino)­
4­(
2­
mefhoxyethoxy)
phenyl)­

Propanenitrile,
3­
2­
chloro+(
2,6­
dichloro+
nitrophenyl)
azo
phenyl
amino­

Propanenitrile,
3,3'­
4­
(2,6­
dichloro­
4­
nitrophenyl)
azo
phenyl
imino
bis­

Propanenitriie,
3­[[
2­(
acetyloxy)
ethyi][
4­~(
4­
nittophenyl)
azo]
phenyl)
amino]­

Acetamide,
N+
bis­
2­(
acetyloxy)
ethyl
amino­
2­(
2,4­
dinitrophenyl)
azo
phenyl­

Acetamide,
N­(
2­((
2­
chloro­
4,6­
dinitrophenyl)
azo)­
5­(
ethylamino)­
4­(
2­
metho~
ethoxy)
phenyl)­

Propanenitrile,
3­((
2­(
2­
cyanoethoxy)
ethyl)(
4­((
4­
nitrophenyl)
azo)
phenyl)
amino)­

Acetamide,
N­(
4­
chloro­
2­((
2­
chloro­
4­
nitrophenyl)
azo)­
5­((
2­
hydro~
propyi)
amino)
phenyl)­

2,4,10­
Trioxa­
7­
azaundecan­
1
I­
oic
acid,
7­(
4­((
2­
cyano­
4­
nitrophenyl)
azo)­
3­
methyiphenyl)­
3­
oxo­,
methyl
ester
Acetamide,
­(
2­((
2­
chloro­
4­
nitrophenyl)
azo)­
5­((
2­
cyanoethyl)­
2­
propenylamino)
phenyl)­

Structual
Class­
5­(
Phenylazo)­
8­(
phenylamino)­
l­
naphthalenesulfonic
acid
salts
I­
Naphthalenesulfonic
acid,
5­((
2­
chloro­
4­
nitrophenyl)
azo)­
8­
phenylamino­,
sodium
salt
I­
Naphthalenesulfonic
acid,
5­[(
3­
chlorophenyl)
azo]­&(
phenylamino)­,
monosodium
Structual
Class­
5,8­
bis(
phenylazo)­
2­
suifonaphthalenes
Z­
Naphthalenesulfonic
acid,
5­((
4­(
bis(
2­
hydroxyethyl)
amino)
phenyl)
azo)­
8­((
2­
methylphenyl)
azo)­,
mono­
sodium
salt
2.
Naphthalenesuifonic
acid,
5(
or
8)­((
4­
hydroxy­
2­
methylphenyl)
azo)­
8(
or
5)­(
phenylazo)­,
monosodium
salt
2­
Naphthalenesulfonic
acid,
5(
or
8)­((
4­
ethoxy­
2­
methylphenyl)
azo)­
8(
or
5)­(
phenylazo)­,
sodium
salt
Structual
Class­
5&
bis[(
naphthyl
or
phenyl)
azo]­
2­
sulfonaphthalenes
1,5­
Naphthalenedisulfonic
acid,
3­((
4­((
4­((
6­
amino­
l­
hydroxy­
3­
sulfo­
2­
naphthalenyl)
azo)­
6­
sulfo­
l­
naphthalenyl)
azo)­
I­
naphthalenyl)
azo)­,
tetrasodium
salt
I­
Naphthalenesulfonic
acid,
8­(
phenylamino)­
5­((
4­(
phenylazo)­
6­
sulfo­
l­
naphthalenyl)
azo)­,
disodium
salt
2­
Naphthalenesulfonic
acid,
8­((
4­((
4­
amino­
3­
suifophenyl)
azo)­
6­
sulfa­
I­
naphfhalenyl)
azo)­
5­((
6.
(benzoylamino)­
l­
hydroxy­
3­
sulfo­
2­
naphthalenyl)
azo)­,
tetrasodium
salt
Structual
Class­
5­[[
4­[(
3­
Sulfophenyl)
azo]­
l­
naphthalenyl]
azo]
naphthalene
sulfonic
acid
salts
I­
Naphthalenesulfonic
acid,
8­(
phenylamino)­
5­((
4­((
3­
sulfophenyl)
azo)­
1­
naphthalenyl)
azo)­,
disodium
salt
2­
Naphthalenesulfonic
acid,
6­
hydroxy­
5­((
4­((
4­(
phenylamino)­
3­
sulfophenyl)
azo)­
l­
naphthalenyl)
azo)­
,disodium
salt
x
Federal
Register
/
Vol.
67,
No.
146
/Tuesday,
July
30,
2002
/Notices
TABLE
4.­
Two
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITH
PREDICTED
BCFs
OF
3­
13­
Continued
CAS
No.
Chemical
name
Structual
Class­
5­
Azo­
2,6­
dialkylamino­
4­
methyl­
3­
pyridinecarbonitriles
63833­
78­
3
72968­
71­
9
3­
Pyridinecarbonitrile,
5­
(2.
cyano­
4­
nitrophenyl)
azo
­6­
(2­
hydroxyethyl)
amino
2­
Thiophenecarboxylic
acid,
4­
cyan~
5­((
5­
cyano­
2,6­
bis((
3­
methoxypropyl)
amino)­
4­
methyl­
3­
pyridinyl)
azo)­
3­
methyl­,
methyl
ester
Structual
Class­­
Azobis(
4,1­
phenyleneazo)
bis(
naphthalenesulfonates)

52469­
75­
7
Trisodium
5­
amino­
3­((
4­((
4­((
7­
amino­
l­
hydroxy­
3­
sulphonato­
2­
naphthyl)
azo)
phenyl)
azo)
phenyl)
azo)­
4­
hydroxynaphthalene­
2,7­
disulphonate
72017­
89­
I
72017­
91­
5
2,7+!
aphthalenedisulfonic
acid,
3,3'­(
azobis(
4,1­
phenyieneazo))
bis(
5­
amino­
4­
hydroxy­,
tetrasodium
salt
2,7­
Naphthalenedisulfonic
acid,
5­
amino­
3­((
4­((
4­((
8amino­
S­
hydroxy­
3,6­
disulfo­
2­
naphthalenyl)
azo)­
3­
methoxyphenyl)
azo)
phenyl)
azo)­
4­
hydroxy­,
tetrasodium
salt
75173­
68­
1
Copper,
(mu­((
3,3'­(
azoxybis((
2­
hydroxy­
4,
l­
phenylene)
azo))
bis(
4­
hydroxy­
2,7­
naphthalenesulfonato))(&)))
di­,
tetrasodium
93941­
06­
l
99869­
36­
O
99869­
37­
I
<24605­
62­
Q
2,7­
Naphthalenedisulfonic
acid,
3,3'­(
azoxybis((
Z­
methoxy­
4,
l­
phenylene)
azo))
bis(
4,
bdihydroxy­

2,7­
Naphthalenedisulfonic
acid,
3,3'­(
azoxybis((
2­
methoxy­
4,1­
phenylene)
azo))
bis(
4,5­
dihydroxy­~
lithium
salt
2,7­
Naphthalenedisulfonic
acid,
3,3'­(
azoxybis((
2­
methoxy­
4,1­
pheny~
ene)
azo))
bis(
4,5­
dihydroxy­,
sodium
salt
2,7­
Naphthalenedisulfonic
acid,
5­
amino­
3­[[
4­[[
4­((
8­
amino­
l­
hydroxy­
3,6­
disu~
fo­
2­
naphthalenyl)
azo]~
Z­
methylphenyl]
azo]­
4­
hydroxy­,
lithium
sodium
salt
Structual
Class­
Biphenylbis(
azonaphthalenesulfonates)

4198­
19­
O
2,7­
Naphthalenedisulfonic
tetrasodium
salt
acid,
3,3'­((
3,3'­
dimethoxy(
1
,l'­
biphenyl)­
4,4'­
diyl)
bis(
azo))
bis(
4,5­
dihydroxy­,

3770­
03­
3
Cuprate(
4­),
(mu­((
4,4'­((
3,3'­
di(
hydroxy­
kappaO)(
l,
Z'­
biphenyl)~,
4'­
diyl)
bis(
azo­
kappaNl))
bis(
3­(
hydroxy­
kappaO)­
2,7­
naphthalenedisulfonato))(
8­)))
di­.
tetrasodium
28407­
37­
6
2,7­
Naphthalenedisulfonic
acid,
3,3'((
3,3'­
dihydroxy(
l,
l'­
biphenyl)­
4,4'­
diyl)
bis(
azo)
bis(
5­
amino­
4­
hydroxy­,
so­
dium
salt,
copper
complex
66418­
17­
5
Cuprate(
[.
mu.­[
4­[[
4'­~(
6­
amino­
l­
hydroxy­
3­
sulfo­
2­
naphthalenyl)
azo]­
3,3'­
dihydroxy(
1
,I'­
biphenyl)­
4­
yl)
azo]­
3­
hydroxy­
2,7­
naphthalene
disulfonato(
7­)]
Jdi­,
trisodium
67952­
80­
I
Cuprate(
4­),
(mu­(
5­(
acetylamino)­
3­((
4'­((
8­
amino­
1­
hydroxy­
3,6­
disulfo­
2­
naphthalenyl)
azo)­
3,~­
dihydroxy(
l,
l'­
biphenyl)
4­
yl)
azo)­
4­
hydroxy­
2,7­
naphthalenedisulfonato(
8­)))
di­,
tetrasodium
68133­
82­
4
68259­
04­
I
Chromate(
Z),
bis(
2­((
6­
amino­
l­
hydroxy­
3­
sulfo­
Z­
naphthalenyl)
azo)
benzoato(
3­))­,
dihydrogen
Acetic
acid,
2,2'­((
4,4'­
bis((
6­((
1­
hydroxy­
4­(((
2­
methoxyethoxy)
carbaryl)
amino)
phenyl)
amino)­
3­
sulfo­
2­
naphthalenyl)
azo(
l,
1'­
biphenyi)­
3.3'­
diyI)
bis(
oxy))
bis­,
disodium
salt
71550­
22­
6
2,7­
Naphthaienedisulfonic
acid,
3,3'­((
3,3'­
dimethoxy(
l,
1'­
biphenyl)­
4,4'­
diyI)
bis(
azo))
bis(
5­
amino~­
hydrox~,
tetraiithium
salt
71873­
63­
7
Cuprate(
~.
mu.­[
7­[[
3,3'­
dihydroxy­
4'­[(
4­
hydroxy­
2­
sulfobenzo[
a]
phenazin­
3­
yl)
azo­
kappaN1)(
1,1'­
biphenyl)~
4­
yl)
azo­
kappaNl)­
8­(
hydrozy­
kappaO)­
1
,3,6­
naphthalenetrisulfonato(&)))
di­,
tetrasodium
salt
Structual
Class­
Bis[
1',
2'­
dihydro­
6'­
hydroxy­
4'nethyl­
2'­
oxo­
l,
3'­
bipyridiniums]

71032­
99­
O
1,3'­
Eipyridinium,
5',
5"`­(
1
,2­
ethanediylbis(
4,2­
phenyleneazo))
bis(
l',~~
ihydro­~­
hydroxy­~­
methyl­~~
xo~,
salt
with
2­
hydroxypropanoic
acid
(1:
2)

75214­
63­
O
650528­
g
7147­
42­
4
1,3'­
Bipyridinium,
5'­[[
4­[[
4­[(
1',
2'­
dihydro­
6'­
hydroxy­
3,4'­
dimethyl­
2'­
oxo[
l
,3'­
bipyridinium)&`­
yl)
azo)
benzoyl)
amino)
phenyl)
azo)­
l',
3'­
dihydro­
6'­
hydroxy­
3,4'­
dimethyl­
2'­
oxo­,
salt
with
2­
hydroxypropanoic
acid
(1:
2)

Structual
Class­
Bis[
2­(
phenylazo)­
3­
oxo­
N­
phenylbutanamides]

Butanamide,
2,2'­((
3,3'­
dimethoxy(
1,1'­
biphenyl)­
4,4'­
diyl)
bis(
azo))
bis(
3­
oxo­
N­
phenyl­

Butanamide,
2,2'­((
3,3'­
dimethoxy(
l,
1'­
biphenyl)­
4,4'­
diyl)
bis(
azo))
bis(
N­(
2­
methyIphenyl)­
3­
oxo­

13
49542
Federal
Register
/Vol.
67,
No.
146
I
Tuesday,
July
30,
2002
/Notices
TABLE
4.­
Two
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITW
PREDICTED
BCFs
OF
3­
13­
Continued
CAS
No.
I
Chemical
name
681.55­
71­
5
Benzamide,
4­((
1­(((
2­
methoxyphenyl)
amino)
carbonyl)­
2­
oxopropyl)
azo)­
N­(
4­((
1­(((
2­
methoxyphenyl)
amino)
carbonyl)­
Z­
oxopropyl)
azo)
phenyl)­

68516­
73­
4
1,4­
Benzenedicarboxylic
acid,
2,2'­[
I
,4­
phenylenebis[
imino(
I­
acetyl­
2­
oxo­
2,1­
ethanediyl)
azo))
bis­,
tetramethyl
ester
77804­
81­
O
Butanamide,
2,2'­(
1,2­
ethanediylbis(
oxy­
2,1­
phenyleneazo))
bis(
N­
(2,3­
dihydro­
2­
oxo­
IH­
benzimidazol­.
5­
yl)­
3­
oxo­

Structual
Class­
Diaminoanthraquinones
4403­
90­
I
m­
Toluenesulfonic
acid,
6,6'­(
1,4­
anthraquinonylenediimino)
di­,
disodium
salt
67827­
60­
5
2­
Anthracenesulfonic
acid,
l­
amino­
4­((
3­((
benzoylamino)
methyl)­
2,4,6­
trimethylpheny~)
amino)­
9,
lO­
dihydro­
9,10­
dioxo­,
monosodium
salt
67969­
88­
4
P­
Anthracenesulfonic
acid,
l­
amino­
4­((
4­(((
4­
methylphenyl)
sulfonyl]
oxy]
phenyl)
amino)­
9,
lO­
dihydro­
Q.
l0­
dioxo­,
monosodium
salt
67970­
27­
8
Benzenesulfonic
acid,
2,2'­((
9,
lO­
dihydro­
9,1O­
dioxo­
l,
4­
anthracenediyl)
diimino)
bis(
5­
methyl­,
diammonium
salt
72391­
24­
3
Benzenesulfonic
acid,
[[(
chloroacetyl)
amino]
methyl]~
4­[[
4­(
cyciohexylamino)­
Q,
lO­
dioxo­
l­
anthracenyl)
amino)
phenoxy)
methyl­,
monosodium
salt
Structual
Class­
N­(
2,3­
dihydro­
2­
oxo­
lH­
benzimidazol­
5­
yl)­
4­
[[
4­[(
methylamino)
suIfonyl]
phenyl]
azo]­
3­
hydroxy­
2­
naphthalenecarboxamides
3771­
33­
9
2­
Naphthalenecarboxamide,
­(
2,3­
dihydro­
2­
oxo­~
H­
benzimidazoI­
5­
yl)­
Q­((
2,5­
dimethoxy­
4­
((
methyiamino)
sulfonyl)
phenyl)
azo)­
3­
hydroxy­

Structual
Class­
­(
2.3­
dihydro­
2­
oxo­
IH­
benzimidazol+
yl)+
[[
4­[(
methylamino)
sulfonyl]
phenyl]
ato]­
3­
hydroxy­
2­
naphthalenecarboxamides
18269­
75­
6
2­
Naphthalenecarboxamide,­(
2,3­
dihydro­
2­
oxo­
lH­
benzimidazol­
5­
yl)­
3­
hydroxy­
4­((
2­
methox~
5­
methyl­
4­
((
methylamino)
sulfonyl)
phenyl)
azo)­

61951­
98­
2
Structual
Class­
N­(
atylazo)
phenyl
(disuIfonaphthyl)
azobenzamides
70900­
28­
6
2,7­
Naphthalenedisulfonic
acid,
cl­
amino­
3­((
4­(((
4­((
4­
amino­
2­
hydroxyphenyl)
azo)
phenyl)
amino)
carbonyI)
phenyl)
azo)­
5­
hydroxy­
6­((
4­
sulfophenyl)
azo)­,
trisodium
salt
72245­
55­
7
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
3­((
4­(((
4­((
7­
amino­
l­
hydroxy­
3­
sulfo­
2­
naphthalenyl)
azo)
phenyl)
amino)
carbonyl)
phenyl)
azo)­~
hydroxy­
6­(
phenylazo)­,
sodium
salt
72245­
57­
9
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
3­((
4­(((
4­((
2­
amino­
4­
hydroxyphenyl)
azo)
phenyl)
amino)
carbonyl)
phenyl)
azo)­
5­
hydroxy­
6­(
phenylazo)­,
sodium
salt
3441­
14­
3
3626­
36­
6
7925.5­
95­
l
68385­
96­
6
72968­
82­
2
63134­
15­
6
67338­
62­
9
Structual
Class­
N,
N'­
bis[(
arylazo)
sulfonaphthyl]
urea
salts
2­
Naphthalenesulfonic
acid,
3­((
4­(
acetylamino)
phenyl)
azo)­
4­
hydroxy­
7­((((
5­
hydroxy­
6­(
phenylazo)­
7­
sulfo­
2­
naphthalenyl)
amino)
carbonyl)
amino)­,
disodium
salt
2­
Naphthalenesulfonic
acid,
7,7'­(
carbonyldiimino)
bis(
4­
hydroxy­
3­(
phenylazo)­,
disodium
salt
2­
Naphthalenesulfonic
acid,
7,7'­(
carbonyldiimino)
bis(
4­
hydroxy­
3­((
2­
methyl~­
sulfophenyl)
azo)­,
sodium
salt,
compd.
with
2,2',
2"­
nitrilotris(
ethanol)

Structual
Class­
N­[
2­[(
2,6­
dicyano­
l­
methylphenyl)
azo]­
5­(
dialkylamino)
phenyljmethanesulfonamides
Methanesulfonamide,
­[
2­[(
2,6­
dicyano­
4­
methylphenyl)
azo]­
5­(
diethylamino)
phenyl]­

Methanesulfonamide,
N­
2­(
2,6­
dicyano­
4­
methylphenyl)
azo­
5­(
dipropylamino)
phenyl
Structual
Class­
N­[
S­(
amino)­
2­([
5­(
ethylthio)­
1
,3,4­
thiadiazol­
2­
yl]
azo]
phenyl]
acetamides
Acetamide,
­5­(
dipropylamino)­
2­
5­(
ethylthio)­
l,
3,4­
thiadiazol­
2­
ylazo
phenyl­

Acetamide,
­(
5­(
ethyl(
phenylmethyl)
amino)­
2­((
5­(
ethylthio)­
l
,3,4­
thiadiazol­
2­
yl)
azo)
phenyl)­
Federal
Register
/
Vol.
67,
No.
146
/Tuesday,
July
30,
2002
/Notices
49543
TABLE
4.­
Two
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITH
PREDICTED
BCFs
OF
3­
13­
Continued
CAS
No.

20025­
74­
5
Chemical
name
Structual
Class­
Sulfonaphthyl­
substituted
4,
l­
diazophenyl
compounds
1,3,5­
Naphthalenetrisulfonic
acid,
7­((
4­((
4­((
2,5.6­
trichloro­
4­
pyrimidinyl)
amino)
phenyl)
azo)
pheny~)
azo)­,
tri­
sodium
salt
68460­
07­
I
124649­
82­
7
67969­
92­
O
72066­
88­
7
3214­
47­
g
28706­
21­
o
28706­
22­
I
67969­
87­
3
71873­
47­
7
2390­
59­
2
2390­
60­
5
2580­
56­
5
1064­
48­
8
1580­
44­
I
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
3­[[
4­[(
2­
amino­
4­
hydroxyphenyl)
azo]
phenyl]
azo]­
5­
hydroxy­
6­
(phenylazo)­,
disodium
salt
2­
Naphthalenesulfonic
acid,
4­
hydroxy­
3­[[
2­
methoxy­
5­
meth~~­[(
4­
sulfophenyl)
azo]
phenyl]
azo]­`
l­
(phenylamino)­,
cmpd.
with
[nitrilotris(
2,1­
ethanediyioxy)]
tris[
propanol]
(1:
2)

Structual
Class­
Sulfonaphthyl­
substituted
diphenylamine­
4,4'­
diazo­
2­
sulfonic
acid
salts
2­
Naphthalenesulfonic
acid,
6­
amino­
3­[[
4­[[
4­[(
7­
amino­
l­
hydroxy­
3­
sulfo­
2­
naphthalenenyl]
azo]
phenyl]
amino]­
3­
suifophenyl]
azo]­
4­
hydroxy­,
trisodium
salt
Structual
Class­
Sulfonaphthyl­
substituted
diphenylamine­
4,4'­
diazo­
2­
sulfonic
acids
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
3­((
4­((
4­((
2­
amino­
4­
hydroxyphenyl)
azo)
phenyl)
amino)­
3­
sulfophenyi)
azo)­
5­
hydroxy­
6­(
phenylazo)­

Structual
Class­
Sulfonaphthyl­
substituted
N,
N'­
bis(
azophenyl)
urea
salts
1,5Naphthalenedisulfonic
acid,
3,3'­(
carbonylbis(
imino(
2­
methyl­
4,1­
phenylene)
azo))
bis­,
tetrasodium
salt
1,3­
Naphthalenedisulfonic
acid,
7,7'­(
iminobis(
carbonyl(
2­
methyl­
4,
I­
phenylene)
azo))
bis­,
tetrasodium
salt
1,5Naphthalenedisulfonic
acid,
3,3'­(
carbonyibis(
imino(
3­
methoxy­
4,1
­phenylene)
azo))
bis­,
tetrasodium
salt
1,3­
Naphthalenedisulfonic
acid,
7­((
4­((((
2­
methoxy­
4­((
3­
sulfophenyl)
azo)
phenyl)
amino)
carbonyl)
amino)­
2­
methylphenyl)
azo)­,
trisodium
salt
Benzoic
acid,
3­((
I­
hydroxy­
6­((((
4~((&
hydroxy­
3,6­
disulfo­
I­
naphthalenyl)
azo)­
2­
methoxy­
5­
methylphenyl)
amino)
carbonyl)
amino)­
3­
sulfa­
2­
naphthalenyl)
azo)­
4­
methoxy­,
tetrasodium
salt
Structual
Class­
Tris(
aminoaryl)
methanamimnium
compounds
Ethanaminium,
­(
4­(
bis(
4­(
diethylamino)
phenyl)
methyiene)­
2,5­
cyclohexadien­
l­
ylidene)­
N­
ethyl­,
chloride
Ethanaminium,
­(
4­((
4­(
diethylamino)
phenyl)(
4­(
ethylamino)­
l­
naphthalenyl)
methylene)­
2,
dcyclohexadien­
l­
ylidene)­
N­
ethyl­,
chloride
2­
Methanaminiom,
N­(
4­((
4­(
dimethylamino)
phenyl)(
4­
(phenylamino)­
I­
naphthalenyi)
methylene)­
2,5­
cyclohexadien­
I­
ylidene)­
N­
methyl­.
chloride
2,7­
Naphthalenedisulfonic
acid,
rl­
amino­
5­
hydroxy­
3­((
4­
nitrophenyl)
azo)­
6­(
phenylazo)­,
disodium
salt
2­
Naphthalenesulfonic
acid,
7­
amino­
4­
hydroxy­
3­((
5­
hydroxy­
6­(
phenylazo)­
7­
suif~
2­
naphthalenyl)
azo)­,
diso­
diom
salt
6527­
70­
4
1789­
01­
9
12239­
34­
8
4232­
06­
2
41680­
76­
6
18386­
01­
7
58104­
55­
5
64181­
81­
3
67800­
97­
g
67905­
39­
9
2,9­
Yriphenodioxatinedisulfonic
acid,
6,13­
dichloro­
3,10­
bis(
phenylamino)­,
disodium
salt
Cuprate(
2­),
(mu­((
7,7'­
iminobis(
3­((
b(
aminosuIfonyl)­
2­(
hydroxy­
kappaO)
phenyi)
azo­
kappaNl)+(
hydroxy­
kappaO)­
2­
naphthalenesulfonato))(
6­)))
di­,
disodium
Acetamide,
­(
5­(
bis(
2­(
acetyloxy)
ethyl)
amino)­
2­((
2­
bromo­
4,6­
dinitrophenyl)
azo)­
4­
ethoxyphenyl)­

Benzenemethanamine,
N­
ethyl­
N­
4­(
1
H­
1,2,4­
triazol­
3­
ylazo)
phenyl
­

1,4­
Benzenedicarboxylic
acid,
2,5­
bis(
4­
chlorophenyl)
amino­

.beta.­
Alanine,
N­
ethyl­
N­~
4­[(
5­
nitro­
2,1­
benzisothiazol­
3­
yl)
azoJphenyl]­,
methyl
ester
2­
Naphthalenesulfonamide,
6­
hydroxy­
N­(
2­
hydroxyethyl)­
N­
methyl­
5­((
4­(
phenylazo)
phenyl)
azo)­

7­((
4­
Chloro­
6­((
3­
sulfophenyl)
amino)­
l,
3,5­
triazin­
2­
yl)
amino)­
4­
hydroxy­
3­((
4­
methoxy­
2­
sulfophenyl)
azo)­
2­
naphthalenesulfonic
acid,
trisodium
salt
Chromate(
l­),
bis(
3­(
4­((
5­
chloro­
2­
hydroxyphenyl)
azo)­
4,5­
dihydro­
3­
methyl­
5­
oxo­
IH­
pyrazol­
I­
yl)
benzene
sulfonamidato(
2­)­,
sodium
Aluminum,
tris(
triacontyl)­

­
..­~­
­­
­­­
49544
Federal
Register/
Vol.
67,
No.
146
/Tuesday,
July
30,
2002
/Notices
TABLE
4.­
Two
HUNDRED
EIGHT
NON­
HPV
DEBITS
CHEMICALS
WITH
PREDICTED
BCFs
OF
3­
I$­
Continued
CAS
NO.

67907­
I
3­
5
Chemical
name
Benzenesulfonic
acid,
2­((
4­((
4­(((
4­
methyIphenyl)
suifonyl)
oxy)
phenyl)
azo)
phenyl)
amino)­
5­
nitro­,
monosodium
salt
68958­
98­
5
70209­
93­
7
Benzenesulfonic
acid,
3­((
4­((
4­
hydroxyphenyl)
azo)­
l­
naphthalenyi)
azo)­,
monosodium
salt
Benzoic
acid,
2­((
8­((
4­
chloro­
6­((
4­(
6­
methyl­
7­
sulfo­
2­
benzothiazolyl)
phenyl)
amino)­
l
,3,5­
triazin­
2­
yl)
amino)­
I­
hydroxy­
3,6­
disulfo­
Z­
naphthalenyl)
azo)­,
tetrasodium
salt
70209­
98­
z
Benzenesulfonic
acid,
2­((
I­(
Z­
chloro­
6­
methylphenyl)­
4,5­
dihydro­
3­
methyl­
5­
oxo­
lH­
pyrazol­
4­
yl)
azo)­
4­((
4­
chloro­
6­(
phenylamino)­
l,
3.5­
triazin­
2­
yl)
amino)­,
monosodium
salt
70528­
90­
4
71735­
65­
4
3­
Pyridinecarbonitrile,
5­((
4~
chloro­
2­
nitrophenyl)
azo)­
l­
ethyl­
l
,2­
dihydro­
6­
hydroxy­
4­
methyl­
2­
oxo­

Tetrasodium(
8­
hydro~­
7­((
2­
hydroxy­
7­
sulpho­
6­((
4­((
2,5,6­
trichloro­
4­
pyrimidinyl)
amino)
phenyl)
azo)­
1­
naphthyl)
azo)
naphthalene­
I
,3,6­
trisulphonato(
6­))
cuprate(
4­)

72252­
58­
5
Chromate(
4­),
(mu­(
3­((
2­(
amino­
kappaN)&
(hydroxy­
kappaO)­
6­((
2­(
hydroxy­
kappaO)&
nitro­
3­
sulfophenyl)
azo­
kappaN1)­
7­
sulfo­
l­
naphthalenyl)
azo­
kappaN1)­
2­
hydroxy­
5­
sulfobenzoato(
8­)))
di­,
tetrasodium
72828­
69­
d
Benzenesulfonic
acid,
2­((
5­
amino­
3­
methyl­
1­(
3­
sulfophenyl)­
lH­
pyrazol­
5­
yl)
azo)­,
methylethylidene)
di­
4,1­
phenylene)
ester,
disodium
salt
l,
l'­((
l­

73309­
47­
4
78181­
99­
4
I­
Naphthalenesulfonic
acid,
4,4'­((
4,6­
dihydroxy­
l,
3­
phenylene)
bis(
azo))
bis­,
disodium
salt
I­
Propanaminium,
3­((
2­
cyano­
3­(
4­(
diethylamino)
phenyl)­
l­
oxo­
2­
propenyl)
oxy)­
N­(
2­((
2­
cyano­
3­(
4
(diethylamino)
phenyl)­
l­
oxo­
2­
propenyl)
oxy)
ethyl)­
N.
N­
dimethyi­,
chloride
85392­
59­
2
Iron,
[.
mu.­[
3­[[
5­[[
2,4­
dihydroxy­
5­[(
2­
hydroxy­
3­
nitro­
5­
sulfophenyl)
dihydroxyphenyl)
azo)­
2­
hydroxy­
5­
nitrobenzenesulfonato(
6­)))
di­
azo]
phenyl)
phenyl)
methyl­
2,4
112484­
44­
3
2,7­
Naphthalenedisulfonic
acid,
4­
amino­
6­((
4­(((
4­((
2,4­
diaminophenyl)
azo)
phenyl)
phenyl)
azo)­%
hydroxy­
3­((
4­
nitrophenyl)
azo)­,
potassium
sodium
salt
amino)
sulfonyl)

130201­
55­
7
Benzenesulfonic
acid,
3,3'­[[
6­(
4­
morpholinyl)­
l,
3,5­
triazine­
2,4­
diyl]
bis[
imino[
2­(
acetylamino)­
4,
l­
phen­
ylene]
azo]]
bis­,
disodium
salt
IV.
Revisions
to
the
TSCA
Section
4(
e)
Priority
Testing
List
1.
Benzme,
1,3,5­
tri~
ror~
io­
2­(
2­
popenylo.
q+
­i.
Reco~
nme~~
dulion.
Het~
ene.
1,3,5­
tril~
rotno­
2­(
2­~~
ro~
t~
3~~~
ioxy)­
(CAS
No,
3278~
W­
5)
is
recommended
to
obtain
unpublished
exposure,
environmetdal
fte.
health
effects,
snd
ecological
effects
data.
ii.
Rutionnle
/br
~~
ecommerrdotion.
Benzene,
1,3,~­
lril~
r.
omo­
2­(
2­
pro~
ettyloxy)­
is
pradiclecl
to
persist
and
biocotlcentrate.
There
are
vary
few
toxiaity
data.
Depending
on
the
exposure,
cmvironmental
fate,
health
effecls,
and
ecological
effects
data
that
are
provided.
&he
EPA
mav
consider
hettzene.
i,
3,
s­
trihrotno­
2­(
2­~
r,;~~~~
t~!~
ioxp)­
for
their
PB'1
Initiative.
iii.
Supporting
ir~`
om7fftAm.
Hanasm,
1,3,5­
tribromo­
2­(
2­
proponyloxy]­
is
produced
in
excess
of
500,000
pounds
pc>
r
annum
and
usad
as
a
flame
retardant
for
expanded
polys?
ymno
insulation
board.
`The
predicted
HCF
of
benzene,
1,3,5­
tribromo­
2­(
2­
l~~
openyloxy)­
is
4,019.
Tho
rat
oral
LDSO
was
5
grams/
kilograms
(g/
kg)
and
it
was
not
mutagenic
in
an
Ames
assay.
A
`IUXLINE
search
identified
onto
report
that
benzene,
1,3,5­
tribrottto­
2­(
2­
propenyloxy)­
was
detected
in
sewer
slime
(Ref.
13).
iv,
Injimnation
mwds.
The
ITC
needs
exposure,
environmental
f&.
health
effects.
and
ecological
effects
data.
Only
studies
where
henzone,
1,3,5­
tribromo­
2­(
2­
propenyloxy)­
is
S
90%
of
the
test
substance
by
weight
should
be
submitted.
2.
I­
Triaeene,
1,3­
di@
enyl­
i.
I?
econuncnd~
ftion.
l­
Triazatis,
1,:
3­
dipttenpl
(diazoam~
lobenzet~
le)
(MS
No.
1X­
35­
6)
is
being
rccotnmended
to
obtain
amlual
production/
importation
volumes
and
trends.

use.
exposure,
and
health
effects
data.
ii.
Rutionnle{
or
mcmrrmzmd~
ztion.
No
occupational
exposure
limits
have
boon
established
by
the
American
Confi?
rence
of
Government
Industrial
H.
ygionists
(ACGIH).
the
National
Institute
for
Occupational
Safety
and
Health
(NIOSH),
or
the
Occupational
Safety
and
Health
Administration
(OSHA).
Occupational
exposures
have
not
been
charecteriaed
and
there
are
no
estitnatos
of
the
number
of
workers
exposed.
The
UC
needs
occupational
exposure
data
from
the
uses
of
diazoaminohenzene,
e.
g.,
to
tnanufacture
dyes
and
insecticides.
iii.
Su~~~
orling
in~
o~
fnc~
fion.
A
rec&
t
National
Toxicology
Program
Report
indicatecl
that
diazoaminobenzenc:
is
matabolizud
in
rats
and
tttice
to
the
ktlowrt
carcinogens
benzene
and
aniiina
(Ref.
12).
Although
not
tested
for
carcinogcmicity,
diazttatnittobotlzctnie
is
a
predicted
c:
arcinogen
l~
dsed
on
its
mstdbolism
and
similarity
in
toxic
effects
to
benzene
and
aniline.
Diazoatttittobenzene
is
used
as
an
intermediate,
comploxing
agent,
and
polymer
additive.
It
is
an
itnpurity
in
certain
color
acldi
tives
used
in
cosmetics,
food
products.
and
pharmaoeuticals.
It
may
alsa
he
used
as
a
propellant
for
molding
ofrubbt:
rs
and
plastios
and
as
a
coupler
to
promote
adhesion
of
natural
rubber
to
steel
tire
cords.
Sinoo
tliazoatttittobenzette
has
scmic:
onductittg
properties
it
may
have
applir&
ons
in
the
semi
cottcluctor
indnslry.
Diazoarninobonzene
may
put
workers
at
a
horetoforc:
unrecognized
increased
risk
of
cancer
if
they
are
exposed
in
the
workplace.
`Importation,
production,
use.
anct
exposure
information
will
assist
in
deterruining
if
diazoatttinobenzune
tnay
need
further
testing
to
adt?
qwdle?
lJ~
assess
pOtC%
ilid
hazards
associated
with
occupational
exposures.
iv.
InJorrrMian
needs.­
a.
Recent
non­
CBI
estimates
of
aniiual
production
or
imporlation
volume
data
and
trends.
h.
Use
information,
including
peronntagcs
of
production
or
importation
that
are
associated
with
different
uses.
c;.
Estimates
of
the
number
of
I.
t~~
t~
atis
atid
concentrations
of
diazoaillirlobcnzsnt
componttds
to
which
humans
may
be
exposed
from
use,
manufacturing,
or
procnsstng.
d.
Health
effects
data
including
I'harntacokinetics,
genotoxicity,
suhchromic
Federal
Register/
Vol.
67,
No.
146
/Tuesday,
July
30,
2002
/Notices
49545
and
chronic
toxicity?
reproductive,
and
19.
1991)
(FRL­
39374).
Acetone
is
being
ethoxylates
that
were
recommended
in
ITC's
devdopmfmtal
toxicity,
and
any
hnnran
clala
from
occupationally
cjxposed
workers.
This
removed
from
the
Priorify
Testing
List
37f'a
lTC
Repm­
t
[til
FR
~IGG,
February
2,

information
is
needed
in
order
to
adequately
bncause
it
was
in
the
OK11
SWS
program
19961
(E'KL­
MSI­
Ci),
3YU~
1'K
Repor
(02
FK
access
thn
extent
and
degree
of
exposure
and
(see
llttp://
irptc.
unep.
ch/
irp~
c/
sidsl
0578.
Fabruary
25,1997)
(ML­
5580~
9),
and
potential
hazard
associated
with
sidspubhh~
l
volume
6)
and
because
it
is
41%
'
1'1'c
Report
(63
FR
17658
,
April
9.1998)

diaeoarrlirlobellzene.
included
in
the
EPA's
VCCEP
for
(FRL­
5773­
S).
At
this
time,
the
ITC
is
c.
Only
studies
where
diazoarninobenzslle
reproductive
effects
and
developmental
ronloving
from
the
Priority
Testing
Lisf.
9
is
>90%
of
the
test
substance
by
weight
toxicity
testing
(htlp:
llcvwM~.
epa.
gov/
alkylphenols
and
alkylphenol
ethoxylates
should
be
submiltnd.
ct~
emrtk/
cl~
ildhl~.~~
tn~).
The
EPA
anticipates
hXll
ih0
3TnL
ITC
k?[
JWt,
7
llfXlyl~
Jh?~
d
that
under
the!
VCCEP,
tier
2
testing
for
ethoxylatos
from
the
39
lTC
Report,
aud
4
B.
Chw1icrrl.
s
lbmoved
From
ths
Priority
prfm.
t~
al
developmental
toxicity,
alkylphenols
and
alkylphenol
cthoxylatos
Testing
List
reproductive
and
fertility
affects
testing
will
from
the
41~
1
ITC
Report
(soo
Table
5
of
this
1,
Af:
cfr>
nC!.
Act?
QJne
was
designated
in
the
ho
conducted
for
acetone.
appendix).
`The
rationales
for
removing
these
ITC's
28'"
ITC
Report
for
reproductive
affects
Z.
Twmty
nlkylphcnols
and
nlkylphcnol
alkglphm~
ols
and
alkylphonol
ethoxylatos
s.
r~
testing
as
a
chemical
with
a
low
confidence
cthoxylalcw.
`f?
lt!
lTC
is
continuing
to
review
provided
as
fflolnotes
Lo
Table
5
of
this
refeerencc
dose
or
KfL1
(ae
FK
41212.
August
data
on
the
alkylphenols
and
alkylphenol
appendix.

TABLE
5.­
ALKYLPHENOLS
AND
ALKYLPHENOL
ETHOXYLATES
BEING
REMOVED
FROM
THE
PRIORITY
TESTING
LIST
Report
CAS
No.
Chemical
name
Rationale
37
99­
71­
8
I­
set­
Butyiphenol
1
37
104­
40­
5
4.
Nonylphenol
2
37
1638­
22­
a
4­
n­
Butylphenol
2
37
9002­
93­
I
Polyethylene
glycol
4­(
tert­
octyl)
phenyl
ether
2
37
9038­
19­
5
Polyethylene
glycol
mono(
octyl)
phenyl
ether
3
37
14938­
35­
3
4­
Pentylphenol
2
37
27193­
28­
8
(1,1,3,3­
TetramethylbutyI)
phenol
(mixed
isomers)
3
37
27193­
86­
8
Dodecylphenol
(mixed
isomers)
4
37
68987­
90­
6
Poly(
oxy­
l,
2­
ethanediyl),
*alpha.­(
octylphenyl)­.
omega.­
hydroxy­,
branched
3
39
20427­
84­
3
2­[
2­(
4­
Nonyiphenoxy)
efhoxy]
ethanol
2
39
37205­
87­
I
Poly(
oxy­
1,2­
ethanediyl),
.alpha.­(
isononylphenyl)­.
omega.­
hydroxy­
2
39
68412­
54­
4
Poly(
oxy­
1,2­
ethanediyl),
.alpha.­(
nonylphenyl)­.
omega.­
hydroxy­,
branched
2
39
98113­
10­
t
NP
9
2
39
127087­
87­
o
Poly(
oxy­
1,2­
ethanediyl),
.alpha.­(
4­
nonylphenyl)­<
omega.­
hydroxy­,
branched
2
39
9016­
45­
g
Poly(
oxy­
1,2­
ethanediyl),
.alpha.­(
nonylphenyl)­.
omega.­
hydroxy­
5
39
26027­
38­
3
Poly(
oxy­
1,2­
ethanediyl),
.alpha.­(
rl­
nonylphenyl)­.
omega.­
hydroxy­
5
41
74499­
35­
7
Phenol,
(tetrapropenyl)
derivs.
4
41
68908­
55­
4
Phenol,
polybutene
derivs.
2
41
112375­
88­
9
Phenol,
polyisobutylene
derivs.
2
41
9014­
92­
O
Poly(
oxy­
l,
2­
ethanediyl),
tc(
dodecylphenyl)­"~­
hydroxy­
2
Removal
rationales:
1.
Data
developed
from
testing
4­
tert­
butylphenol
(CAS
No.
98­
54­
4)
in
response
to
the
HPV
Challenge
program
may
be
used
to
predict
tox­
icity.
2.
No
domestic
production
or
importation
volumes
were
reported
to
the
EPA
in
response
to
1986,
1990,
1994,
and
1998
IURs
or
no
domestic
production
or
importation
volumes
were
reported
to
the
EPA
in
response
to
the
July
5,
2000
PAIR
rule
(65
FR
41371)
(FRL­
6589­
1).
3.
Data
developed
from
testing
phenol,
4­(
1,1,3,3­
tetramethylbutyI)­
(CAS
No.
140­
66­
g)
in
response
to
the
HPV
Challenge
program
may
be
used
to
predict
toxicity.
4.
Data
developed
from
testing
p­
dodecylphenol
(CAS
No.
210555­
94­
5)
in
response
to
the
HPV
Challenge
program
may
be
used
to
predict
toxicity.
5.
Data
developed
from
testing
branched
nonylphenol
(CAS
No.
84852­
153)
in
response
to
the
HPV
Challenge
program
may
be
used
to
pre­
dict
toxicity.

Them
are
10
alkylphonols
and
alkylphenol
uthoxylates
remainin::
on
the
Priorify
Testing
List
(sea
Table
6
of
this
appendix].
49546
Federal
Register
/
Vol.
67,
No.
148
/Tuesday,
July
30,
2002
/Notices
TABLE
6.­
ALKYLPHEN~
L~
AND
ALKYLPHENOL
ETHOXY~
ATES
REMAINING
0~
THE
PRIORITY
TESTING
LIST
37
Report
CAS
No.
Chemical
name
80­
48­
6
4­
tert­
Pentylphenol
37
88­
l
8­
8
2­
tert­
Butylphenol
37
98­
54­
4
4­
tert­
Butylphenol
I
37
/
1806­
26­
4
1
4­
Octylphenol
37
I­
25154­
52­
3
Nonylphenol
(mixed
isomers)

I
37
1
84852­
15­
3
1
Branched
nonylphenol
(mixed
isomers)

39
27986­
36­
3
2­(
Nonylphenoxyl)
ethanol
41
1987­
50­
4
Phenol,
rl­
heptyl­

41
72624­
02­
3
Phenol,
heptyl
derivs.

41
140­
66­
g
Phenol,
4­(
1
,I
,3,3­
tetramethylbutyl)­

3.
Thrcx
DlilWS
chemicals
jkxn
the,
4h'lf1
ITC
Report.
In
its
461"
lTC
Report,
the
ITC
discussed
2
groups
of
DEBl'iS
chemicals,
polychloropflellois
and
pol?
rchlorobenzent:
thiols
and
chlorotdfl~
torolIlc~
thyipl~
enoxy
benzenes
(85
FK75552.
Decerhx
1,
ZOOO)
@XL­
6594­
7).
Two
of
the
polychlorophsnols
and
polychloroballzonothiols
[pentacl~
lorotMoI~
henol,
CAS
No.
133­
49­
3
and
tetrachloropyrocate~
hol,
CM
No.
119%
~­
6)
and
two
of
the
chlort)
trifluorometllylphen~~
xy
bsrtzenes
(p­
toluidine,
5­
chloro­.
alpha...
alpha.,.
alpha.­
trifluoro­
2­
niho­
N­
phenyl.
CM
No.
180B­
24­
2
and
benzoic
acid,
3­[
2­
chloro­
4­
(trifluoromf:
thyl]
pl~
enoxy]­,
2­
ethoxy­
l­
mo~
hyl­
2­
oxo,
CAS
No.
88185­
22­
2)
were
subsequently
added
to
the
I+
iori$
Testing
List
in
the
1TC's
471"
ITC
Report.
All
4
of
.these
chemicals
were
added
to
the
July
26,
2001
PAIKruie(
liG
FK
38955)(
E'fCL­
6783­
R).
All
of
those
chemicals,
except
porltachlorclthioph1~
nol,
are
being
removed
from
tile
Priority
Testi17g
List
because
1x3
production
or
importation
data
were
submitted
to
the
EPA
in
response
to
tho
1998
IUR
(10,000
pound
reporting
threshold)
or
tilt?
Tulv
26,
2001
PAIK
rule
(1,000
klound
rep&
t&~
tl&
shold).
4.
Three
DEBITS
chemicds
from
the
47fI'
1'l'CAeport.
In
its
47'"
UC
Report,
the
ITC
added
3
chloroalkenes
to
the
Priority
Y'esling
List:
1,3­
butadiene,
1.,
1.2,3,4­
pentachloro­
4­
(1­
methylolhoxy)­
(CM
No.
6833~
G7­
8);
3­
butenoic
acid.
2,2,3.4,4­
peiltachloro­
butyl
ester
(CM
No.
75147­
20­
9);
and
3­
butenoic
acid,
2,2,:~,
4,4pentar:
hloro­
(CM
No.
85743­
61­
9).
The
ITC
is
removing
these
3
chloroalkenos
from
the
Priority
?`
esGng
List
because
no
production
or
importation
data
were
submitted
to
the
WA
in
respnnso
to
the
1998
IUR.
8.
Nine
DEBITS
cl~
enticals
from
the
4Hl"
1X
lieport.
1x1
its
48'"
ITC
Report.
the
ITC
added
5
chlorinated
trihalomethyl
pyridines,
2
trihaloethyliden~
bisbenzanes,
4
tricl~
lorophnnyldi~
dropyrazols
and
3­
chloro­
2,6;­
dinitro­
N?
N­
tlipropyl­
4­
(trifluoromethyl]
­benzenoamine
to
the
IWority
Teslirzg
List.
`The
ITC
is
removing
the
the
trihaloathylidone
bisboizctnes
(benzene,
5
chlorinated
trihalomethyl
pyridinos,
1
of
1,
x'­(
2,2,2­
trichloroothylidene)
bis­),
and
3
of
the
trichlorophenvldihydropyrazols
(benzamide,
3­
aul:
lno­
N­[
4.5­
dihgdro­,
5­
oxo­
l­
(2,4,8­
tri~~~
loroph~~~~~
l)­
1H­
pMriiaoll;
3H­
l).\`
razol­
3­
one,
5­((
5~
amino­
2­
chlorophenpl)
alnino)
­2,4­
dihydro­
a­(
2,4,6­
trichlorophsnyl)­;
and
benzamide,
N­(
4,5­
dihydro+
oxo­
l­
(2,4,
B­
lt.
ichloroI~
ht~
llyl)­
1H­
pyrazol­
3­
yl)­
3­
iiilo­)
from
the
Eoriiy
Testing
Lisf
hecause
no
productioii
or
importation
dsta
wem
submitted
to
the
EPA
in
response
to
the
1998
IUR
or
because
tlw
predicted
BCFs
were
judged
lo
be
loo
low
to
warrant
priority
consideration
al
this
time.

V.
References
Register
(45
FR
35897­
35910,
May
2H,
1980).
Priority
?bsting
List
of
Chemicals.
Federal
6.
ITC.
1980b.
Seventh
Report
of
the
TSCA
Interagency
`Testing
Committee
(October
24,
1980)
to
the
Administrator;
Receipt
of
Report
and
Request
for
Comments
Regarding
the
f'rjority
Tcxting
fist
of
Chemicals.
Federal
Register
(45
FR
78432­
78440,
Novembt:
r
25,
1980).
7.
ITC.
1982.
Eluwdh
Report
of
the
TSCA
Interagency
`Tesling
Cormnittee
(November
3,
1982)
lo
the
Administrator:
Receipt
of
Report
and
Request
for
Corrmienls
Kogarding
I+
ior?`
fy
Testjng
Lis/
of
Chornicals.
Federal
Register
(47
E'K
54625­
54044.
L)
aixxb3r
3,
1982).
8.
ITC.
1984.
Foubeenth
Report
of
the
`TSCA
Interagencv
Testing
Committee
(May
8,
1984)
to
the
Adn;
inistrator;
Receipt
of
Report
and
Request
for
Comments
Regarding
Eority
T&
in::
List
of
Chemicals.
Federal
Register
(49FR223W22407,
h'fay29,1984).
1.
lTC.
1977.
Initial
Report
of
the
TSCA
Interagency
Testing
Committee
(October
1,
1977)
to
the
Administrator:
Rocoipt
of
Report
and
Request
for
Commc~~
ts
Regarding
the
fXori!
y
`I%
stin$
List
of
Chemicals.
Federal
Register
(42
FK
55026­
55080.
October
12.
1977).
2.
KC.
197th
Second
Kf!
port
0I
the
`TSCA
Inleragency
Testing
Committee
(April
10,
1978)
lo
the
Administrator;
Receipt
of
Report
md
Request
for
Comments
Regarding
the
Priority
Testing
Lisl
of
Chemicals.
Federal
Register
(43
PR
16684­
10R88,
April
19,
1978).
3.
ITC.
l97Ub.
Third
Report
of
the
TSCR
Interagency
Tosting
Committee
(October
2,
1978)
to
the
Administrator;
Receipt
of
Report
and
Request
for
Comments
Regarding
the
I'riorjtJ/
Tesfing
List
of
Chemicals.
Federal
Regisler
(43
FR
50630­
50635,
October
10,
1978).
4.
ITC.
1979.
Fifth
Report
of
the
TSCA
Interagency
Testing
Committee
(November
8,
1979)
to
the
Administrator;
Receipt
of
Report
and
Request
for
Comments
Regarding
the
I'riorify
`I%
sting
List
of
Chemicals.
Federal
Register
(44
FII
70604­
7~
74,
December
7,
1979).
5.
ITC.
1980a.
Sixth
Report
of
the
TSCh
Interagency
Testing
Committee
(April
9,
1980)
to
the
Administrator;
Receipt
of
Report
a~
ld
Nequest
for
Comments
Regarding
thu
9,
ITC.
1985.
Sixteenth
Report
of
the
TSCA
interagency
Testing
commiltea
(May
2,
lSU.
i)
to
the
Administrator:
Receipt
of
Kepofi
ad
Request
for
Comments
Regarding
I'riorily
Tes@
List
of
Chemicais.
Federal
Register
(60
FK
2093040939,
May
21.1985).
10.
1'X.
1986.
Ninetemth
Report
of
tht!
`I'SCA
Interagency
Testing
Committee
(October
3
1,
198(
S)
to
the
Administrator:
Receipt
of
Report
and
Request
for
Comments
Regarding
priority
Testing
List
of
Chemicals.
FederalRegister
(51
FR41417­
41432,
November
14,
1986).
11.
1TC.
1989.
Twenty­
Bftb
Roport
of
the
TSCA
Interag:
ency
Testing
Committee
(November
1,
1989)
lo
the
Administrator;
Xoceipt
of
Report
and
Request
for
Comments
Regarding
Priority
Tes/
jng
Lisl.
of
Chemicals.
Federal
Kegister
(54
FR
51114­
51130,
Decembsr
12,
1989).
12.
National
Toxicologv
Program
(NTI').
2002.
Toxicity
Report
Se&
es
Number
73.
NW
report
on
the
metabolism,
toxicity,
and
predicted
carcinogenicity
of
diazoaminoborr~
ene
(CAS
No.
136­
35­
6).
U.
S.
Department
of
Health
and
Human
Services,
Public
Health
Service,
Natiorral
institutes
of
Health.
NIH
Publication
No.
Ol­
4412.
Draft
abstract
available
online
at:
http:/
Federal
Register
/Vol.
67,
NO.
146
/Tuesday,
July
30,
2002
/Notices
49547
13.
Sauer
J.,
Antnsch
E.,
and
l?.
i).
m
C.
1997.
Mflnitoring
bf
organic
pollutants
i;;
sewer
systems
by
sewer
slime
analysis.
pp.
49­
69.
In
Haberor
K
(ad.)
Wutcr.
VCH
Publishers,
Inc,.
New
York.
NY.
ISBN
3­
527­
28820­
l.
14.
Walker
JD.
1993.
The
TSCA
Intttragency
Testing
Commitlue,
1977
lo
1992:
Creation,

451­
509.
In
J.
W.
Gorsuch,
F.
J.
Dwycr,
d6.
Ingersoll
and
T.
W.
La
Pointe
(cds.),
Environmentul
Tosicolo~~
and
Hisk
Assossnlef~
l:
Second
v011me,
AS'l?
vf
F­
m
1216.
ASTM,
Philadelphia,
PA.

Vl.
TSCA
I~~
teragency
Testing
Committee
Statutory
Organizations
and
Their
Representatives
Council
on
Envfronmentul
Quulity
Vacant
Department
a/
'
Cummerce
A'ofionul
Inslit~
le
of
Stnndards
rind
Teclmoloav
<,.,
Robert
Huie,
Membor
Barbara
C.
Lsvin,
Alternate
Atmospheric
Administratk~
Thomas
P.
O'Con~
ior,
Member
Tari
Rowles,
Allernale
Environmental
Pratsction
Agency
Paul
Camuanella,
Member
David
R.
%illiams,
Alternate
Nutianal
Cancerlnstitule
Barbara
Lucom,
Member
Alan
Poland,
Member
Kenneth
Still,
Alternate
David
Longfellow,
Alternate
Josi
Centsno,
Alternate
Dopallxnsnl
of
the
Inferior
Harnett
A.
Rattner,
Member
Scott
Maston,
Member,
Chair
William
Eastin.
Allsrndle
Nutional
InsMute
Jor
Occupational
SuJety
and
Henllh
Mark
Toraason,
Member,
Vice
Chair
Dennis
W.
Lynch,
Alternate
Nutionul
Science
Faundutian
A.
Frederick
`Ihompson,
Mmnber
Marge
Cavanaugh,
Alternate
Occuwatianal
Safetv
and
Health
Admin&
r*
tian
'
.
Val
I­
I.
Schaeffer,
:Member
Lyn
Psnniman,
Alternate
Liaison
Organizalirms
and
Their
Representatives
Agency
Jar
Toxic
Substances
and
Disease
Ilegistry
William
Cibulas,
Member
Daphne
Moffett,
Altttrnate
Consumer
Product
Suj&
ty
Commission
lacquelino
Parrante,
Member
`Treye
Thomas.
Alternate
Depurtment
of
Agriculture
Clifford
P.
Rice,
Member
Laurau
L.
McConnell,
Allornate
DepartmerLt
oJ
DeJkst?
Food
and
Drug
Administra
tian
David
Hatlen.
A1tarnale
A~
ational
Lilxcu
y
o
J&
fcNcinr:
Vera
W.
Hudson.
Member
C011nse1
Scott
Sherlock,
OPI'T,
EPA
Ikchnical
sqaport
Cont1nctcJr
Syrat:
uso
Research
Corporation
ITC
stuff
John
D.
Walker,
Exxecutivc
Director
Norma
S.
L.
Williams,
Bxccl~
tive
Assistant
`I'SCA
interagency
Testing
Committee,
Office
of
Pollution
Prevention
and
Toxics
(74OlM),
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
WashingIon,
DC
20460;
telephone
number:
(202)
584­
7527;
fax
number:
(202)
564­
7828;
e­
mail
address:
willi~
ms.
normaQopa.
gov;
url:
http://
www.
apa.
govlopptintr/
ilc.

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