Document ID: EPA-HQ-OPP-2004-0411-0029
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2004-12-21T05:00Z

0812B1GH
[
OVERLAYS]
1
Ametryn
Overview

A
small
active
ingredient
of
limited
commercial
importance

Consideration
of
several
business
options
underway

Syngenta
conditionally
committed
to
limited
support
of
selected
uses

Ametryn
not
notified
for
support
under
List
2
451/
2000
regulation
in
EU;
will
be
withdrawn
from
EU
market
in
2003
0812B1GH
[
OVERLAYS]
2
Ametryn
SMART
Meeting

Syngenta
Use
Patterns
That
Will
Be
Supported
Covered
in
our
Presentation

Syngenta
is
aware
of
other
registrant's
end­
use
products
in
the
marketplace,
but
since
Syngenta
does
not
know
the
source
of
ametryn
technical
in
those
products,
they
are
not
considered
in
our
presentation.
0812B1GH
[
OVERLAYS]
3
Ametryn
Regulatory
History
1964
First
Registration
on
Sugarcane
1969
Registration
on
Corn
1983
Toxicology
Data
Call
 
In
1984
Special
Groundwater
Data
Call
 
In
(
E.
Fate
Data)

1989
FIFRA
88
Reregistration
Process
(
Phase
I
 
III)

1991
Reregistration
Phase
4
Data
Call
 
In
1992
HCB/
PCB
Special
Data
Call
 
In
(
Surrogate
data
on
atrazine
and
simazine
covers
all
triazines)
0812B1GH
[
OVERLAYS]
4
Ametryn
Use
Profile
­
Overview
Syngenta
Label
Rates
Crop
Max.
Single
Rate
Number
Max.
(
AI/
A)

Apps.
Yr./
Crop
Corn
(
Field,
Sweet,
Pop)
2.0
1
2.0
Sugarcane
(
state
dependent)
8.0
5
16.0
State
Use
Programs
FL
1.2
3
3.6
LA
2/
2.4/
2.4/
2.4/
2.4
5
11.6
TX
2/
2/
2
3
6.0
HI
7.2/
2.4/
2.4
3
12.0
8/
4/
4
3
16.0
Sugarcane
Retreatment
intervals:
30
days
where
specified
per
state
PR
0812B1GH
[
OVERLAYS]
5
Sugarcane
Use
In
Puerto
Rico
Currently
no
Sugarcane
in
Puerto
Rico;
75%
of
current
use
in
Puerto
Rico
is
on
Bananas
and
Plantains,
25
%
of
current
use
in
root
crops,
only
preemergence
Timing
Rate
Pounds
Sugarcane
planting
application
3­
4
days
after
planting
4
lbs
30­
45
days
after
first
application
4
lbs
cane
shade
over
Ratoon
Crop
after
Harvesting
application
1­
3
days
after
harvest
4
lbs
30­
45
days
after
previous
application
4
lbs
0812B1GH
[
OVERLAYS]
6
Draft
Ametryn
Usage
Information
Average
of
1999
 
2002
Doane
AgroTrak
Values
Confidential
Business
Information
Deleted
From
Slide
Total
Ametryn
Top
States
(
Up
to
5)

Ranked
Labeled
Max.
Total
Lbs.
AI
Per
Year
Labeled
Max.

Single
or
Split
Lbs./
A
Per
Year
No.
Applic.
Labeled
Per
Year
Avg.
Lbs.

AI
Per
Tractor
A/
Yr
Total
Lbs.
AI
Applied
%
Crop
Treated
Tractor
A/

Grown
Acres
As
%

Ametryn
Tractor
Acres
Crop
Acres
Grown
Syngenta
Ametryn
Label
Sites
Confidential
Business
Information
0812B1GH
[
OVERLAYS]
7
Ametryn
Use1.
in
Corn
and
Sugarcane:

State
Specific
1998­
2002
Average
Base
Acres
Lbs./
Base
Crop
State
Treated
Lbs.
Used
Acre
Confidential
Business
Information
Deleted
From
Slide
1.
Doane
Marketing
Research,
Inc.

Confidential
Business
Information
0812B1GH
[
OVERLAYS]
8
Florida
Fruit
and
Vegetable,
Mr.
Dan
Botts
Summary
of
Discussion
With
Sugarcane
Producers
­­
July
2003
Ametryn
(
Evik
DF)

This
product
is
currently
used
on
approximately
75%
of
the
sugarcane
acreage
in
Florida
on
an
annual
basis.
Application
parameters
are
as
a
single
early
postemergent
application
at
the
use
rate
of
0.25
­
0.50
pounds
of
active
ingredient
per
application.
Most
applications
are
made
using
ground
equipment
with
approximately
20%
of
the
applications
currently
applied
aerially
depending
on
soil
moisture
conditions
due
to
weather.
Primary
weed
targets
are
small
grasses
and
some
broadleaf
weeds.
Estimated
product
usage
is
200,000
pounds
of
product
annually.

The
sugarcane
industry
expressed
tremendous
concern
over
any
potential
restrictions
to
or
loss
of
this
material.
It
represents
an
important
component
in
current
weed
management
practices.
The
per
acreage
cost
of
this
material
when
used
in
combination
with
the
other
weed
control
agents
makes
it
one
of
the
most
economically
effective
tools
in
the
weed
management
tool
box.

The
industry
would
appreciate
being
apprised
of
the
situation
as
it
develops
relative
to
the
continued
regulatory
review
through
the
Reregistration
process.
They
would
be
especially
interested
in
providing
more
information
on
the
efficacy
and
utility
of
the
product
if
the
need
arises.
0812B1GH
[
OVERLAYS]
9
Ametryn
SMART
Meeting
 
Market
Niches
Market
Niche
For
Ametryn
Use:

Corn:
SE
States
for
POST
DIRECTED
application
to
control
TX
panicum,
broadleaf
signalgrass,
fall
panicum,
goosegrass,
nutsedge,
and
certain
broadleaves.
Use
has
decreased
with
introduction
of
more
effective
and
selective
products.

Sugarcane:
Additional
weeds:
Alexander
grass,
itchgrass.
Primary
use
in
FL
where
low
rates
are
used
primarily
with
atrazine
or
2,4­
D
to
improve
postemergence
burndown
activity
of
both
grass
and
broadleaf
weeds.
HI:
Use
pre
and
post
for
specific
broadleaf,
grasses
(
guineagrass,

Chloris
spp.
and
vines
(
aiea
morningglory).
Used
in
combination
with
diuron
or
atrazine.
Potential
for
crop
injury,
especially
post
applications.

Use
in
other
states
is
insignificant.

Syngenta
has
no
plans
to
change
the
corn
or
sugarcane
labels.
0812B1GH
[
OVERLAYS]
10
Ametryn
Uses
No
Longer
Supported
By
Syngenta
Crop
Max.
Single
Rate
Number
Max.
Rate/

(
Ai/
A)
Apps.
Yr/
Crop
(
Ai/
A)

Sugarcane
(
HI
only)
8.0*
3
16.0*

Bananas
(
all
rates)
8.0
4
24.0
Plantains
8.0
4
24.0
Pineapple
8.0*
Not
Stated
30.0*

Noncrop
Land
2.0
3
6.0
*
Occurs
on
51036­
105
0812B1GH
[
OVERLAYS]
11
Ametryn
 
Method
of
Application
Syngenta
Product
Labels
Conventional
Ground
Sprayers
Aerial
Application
Permitted
Use
in
Chemigation
Equipment
is
Prohibited
0812B1GH
[
OVERLAYS]
12
Ametryn
Timing
of
Applications
Syngenta
Product
Labels
Crop
Timing
Instructions
For
Application/
intervals
Corn
(
Field,
Sweet,
Pop)
Apply
as
a
postemergence
directed
spray
to
weeds
after
the
smallest
corn
is
at
least
12
inches
tall
(
measured
to
the
highest
leaf
surface
on
free
 
standing
plants).
Do
not
apply
within
3
weeks
of
tasseling.

Sugarcane
Apply
preemergence
and
postemergence,
as
a
broadcast,
directed
or
interline
prior
to
close
 
in.
0812B1GH
[
OVERLAYS]
13
Ametryn
SMART
Meeting:
Application
Methods
Specific
Application
Methods:

Corn:
Ground
application:
Add
a
surfactant
and
apply
as
a
postdirected
spray
when
the
smallest
corn
is
at
least
12
inches
tall
in
a
minimum
of
20
gals
of
water
or
non­
pressure
Nitrogen
solution
to
assure
complete
weed
coverage.
It
is
recommended
that
gauge
wheels
and/
or
leaf
lifter
equipment
be
used
to
prevent
leaf
contact.

Drop
nozzles
may
be
used,
but
extreme
care
must
be
taken
to
keep
the
spray
or
drift
from
contacting
the
leaves
and
especially
the
whorl.

Entire
spray
pattern
is
directed
downward.
Apply
at
a
spray
pressure
of
30
psi
or
less
to
prevent
"
bounce
back"
 
spray
bouncing
off
soil
or
weeds
and
settling
on
corn
leaves.
Do
not
spray
over
top
of
corn,

or
injury
will
occur.
Do
not
apply
within
3
weeks
of
tasseling.
0812B1GH
[
OVERLAYS]
14
Ametryn
SMART
Meeting:
Application
Methods
(
2)

Sugarcane:
Aerial
Application:
Apply
only
where
broadcast
applications
are
specified
in
a
minimum
5
gal.
total
spray
volume
per
acre.
Make
application
at
a
maximum
height
of
10
ft.,
using
low­
drift
nozzles
at
a
max.
pressure
of
40
psi
when
weed
speed
does
not
exceed
10
mph.
Apply
alone
by
aircraft
at
a
minimum
upwind
distance
of
800
ft.

from
sensitive
plants.

Ground
Application:
Apply
broadcast
or
banded.
Repeat
treatment
may
be
broadcast,
band,
or
interline
with
final
application
prior
to
close
in.
Postemergence
application
may
be
broadcast
or
directed.

Spray
droplet
size
is
not
mentioned
as
a
label
limitation.
Rather,

efficacy
is
more
related
to
total
spray
volume
for
uniform
/
complete
weed
coverage,
and
psi
to
prevent
potential
spray
drift
and
crop
injury.
0812B1GH
[
OVERLAYS]
15
Ametryn
 
Formulation
Type
Syngenta
Product
Label
&
Others
Evik
®
DF,
EPA
Reg.
No.
100­
786:
80%
AI
­
Water
Dispersible
Granule
Ametryn
Technical,
EPA
Reg.
No.
100­
759:
90%
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Unknown
source
of
technical
ametryn
for
end
use:

Ametryne
4L,
EPA
Reg.
No.
51036­
105;
4
lbs.
ai/
gal
Amatryne
80W,
EPA
Reg.
48273­
3;
80%
AI
0812B1GH
[
OVERLAYS]
16
Ametryn
Re­
Entry
Intervals
Syngenta
Product
All
Uses/
Product
=
12
Hour
REI.

No
known
worker
activities
would
be
impacted
by
this
REI
in
corn
and
sugarcane.

There
is
no
potential
use
in
residential,

recreational,
or
other
public
(

nonoccupational
settings.
0812B1GH
[
OVERLAYS]
17
Ametryn
Pre­
Harvest
Intervals
(
PHI)

Syngenta
Product
Label
Crop
PHI
Corn
(
Field,
Sweet,
Pop)
Allow
30
days
after
the
application
before
harvesting,

grazing,
or
feeding
forage
to
livestock.

Sugarcane
Make
the
final
application
prior
to
close
 
in
(~
120
days
before
harvest).
0812B1GH
[
OVERLAYS]
18
Ametryn
 
Equipment
for
Mixing,

Loading
and
Application
Syngenta
Product
Label
Standard
Equipment
Used.

No
Uncommon
Equipment.
0812B1GH
[
OVERLAYS]
19
Ametryn
 
Feeding/
Grazing
Restrictions
Syngenta
Product
Label
Crop
Restriction
Corn
Allow
30
days
after
the
application
before
harvesting,
grazing,
or
feeding
forage
to
livestock
0812B1GH
[
OVERLAYS]
20
Ametryn
Rotational
Crop
Restrictions
Syngenta
Product
Label
Corn:
Small
grains,
such
as
wheat,
oats,
and
rye,

may
be
planted
in
the
fall
following
the
recommended
application.
Do
not
plant
any
rotational
crop
other
than
small
grains
until
the
following
year.
0812B1GH
[
OVERLAYS]
21
Ametryn
 
Post
Harvest
Treatment
Syngenta
Product
Label
This
is
Not
a
Valid
Use
For
Ametryn
0812B1GH
[
OVERLAYS]
22
Ametryn
SMART
Meeting:

Post­
Harvest
Processing
No
concentration
of
residues
in
corn
or
sugarcane
in
processed
fractions
based
on
processing
studies
submitted
to
EPA.

MRIDs
41909501(
corn),
4184660
(
sugarcane)
0812B1GH
[
OVERLAYS]
23
Ametryn
SMART
Meeting;
Applicator
Information
Corn:
Use
is
too
small
to
generate
the
"
typical"

acres
treated
per
day
and
per
season
information.

With
most
of
ametryn
use
in
the
southeastern
states,
large
growers,
acreages,
and
custom
applicators
are
not
common.

Sugarcane:
Use
is
primarily
in
FL
at
an
estimated
average
rate
of
0.25
to
0.5
lb.
ai/
A.
Based
on
this
rate
and
the
relatively
low
percent
of
crop
treated,

worker
exposure
assessments
should
result
in
no
limitation
on
pounds
handled
or
acres
treated
per
applicator
is
justified.
0812B1GH
[
OVERLAYS]
24
Ametryn
Personal
Protection
Equipment
(
PPE)

Requirements/
Types
Syngenta
Product
Label
Applicators/
Other
Handlers
Long­
Sleeved
Shirt
and
Long
Pants
Shoes
Plus
Socks
Engineering
Control
Statements
When
Handlers
in
Closed
Systems,
Enclosed
Cabs,

or
Aircraft
in
a
Manner
That
Meets
Worker
Protection
Standard
(
WPS)
Requirements,
the
Personal
Protective
Equipment
(
PPE)
Requirements
May
be
Reduced
or
Modified
0812B1GH
[
OVERLAYS]
25
Ametryn
 
Buffer
Zones
Syngenta
Product
Label
 
Avoid
using
Evik
DF
where
adjacent
desirable
plants
may
be
injured.

 
Avoid
applications
under
conditions
where
uniform
coverage
cannot
be
obtained
or
where
excessive
spray
drift
may
occur.

 
Aerial
Application:
In
order
to
assure
that
spray
will
be
controllable
within
the
target
area
when
used
according
to
label
directions,
make
applications
at
a
maximum
height
of
10
ft.,
using
low
 
drift
nozzles
at
a
maximum
pressure
of
40
psi,
and
restrict
application
to
periods
when
wind
speed
does
not
exceed
10
mph.
To
assure
that
spray
will
not
adversely
affect
adjacent
sensitive
non
 
target
plants,
apply
Evik
DF
alone
by
aircraft
at
a
minimum
upwind
distance
of
800
ft.
from
sensitive
plants.

 
Do
not
contaminate
water,
food,
or
feed
by
storage
or
disposal.

 
Do
not
apply
directly
to
water,
to
areas
where
surface
water
is
present,

or
to
intertidal
areas
below
the
mean
high
water
mark.

 
Do
not
contaminate
water
when
disposing
of
equipment
wash
water
or
rinsate.
0812B1GH
[
OVERLAYS]
26
Ametryn
 
Restrictions
On
Use
Due
to
Ground
/

Surface
Water
For
Syngenta
Products
There
is
a
Ground
Water
Advisory
Statement
in
the
Environmental
Hazards
Section
Of
The
Label:

Ametryn
is
known
to
leach
through
soil
into
groundwater
under
certain
conditions
as
a
result
of
registered
use.
Use
of
this
chemical
in
areas
where
soils
are
permeable,
particularly
where
the
water
table
is
shallow,
may
result
in
groundwater
contamination.
0812B1GH
[
OVERLAYS]
27
Ametryn
 
Metabolic
Pathway
Plants
Ametryn
is
degraded
by
N­
dealkylation
and
by
hydrolysis
of
the
methylthio
group
through
oxidation
to
the
methylsulfinyl
derivative
and
followed
by
the
formation
of
the
hydroxy
derivative.
The
conjugations
are
formed
with
reduced
glutathion
and
cysteine.
After
a
complete
N­
dealkylation
representing
the
ammeline
structure
the
unsubstituted
aminogroups
may
be
replaced
by
hydroxy
substituents
representing
for
most
plants
the
final
step
of
the
s­
triazine
degradation.
0812B1GH
[
OVERLAYS]
28
Ametryn
 
Metabolic
Pathway
Mammals
MRID
41463301
0812B1GH
[
OVERLAYS]
29
Ametryn
 
Metabolic
Pathway
Ruminants
MRID
41662305
0812B1GH
[
OVERLAYS]
30
Ametryn
 
Metabolic
Pathway
Poultry
MRID
41662303
0812B1GH
[
OVERLAYS]
31
Ametryn
 
Metabolic
Pathway
Aerobic
Soil
MRID
41752401
FD
FD
FD
0812B1GH
[
OVERLAYS]
32
Ametryn
SMART
Meeting:
Alternatives
in
Corn
Ametryn
registered
in
Corn
in
1969.
No
product
at
that
time
controlled
the
problem
corn
weeds
(
grasses
and
broadleaves),
but
use
was
limited
by
corn
selectivity
and
highly
specific
application
method
and
equipment.
Use
(~
0.2%
share)
limited
to
problem
weeds
and/
or
areas
of
lower
potential
corn
yield.
Alternatives,
but
more
costly,
now
exist.

Their
approximate
corn
market
share
listed
below.

Atrazine:
Preemergence
and
postemergence
BL/
GR
control
(
70%)

Nico,
primi,
pro,
rim,
thifensulfuron:
Post
BL
or
GR
control
(
35%)

Acetanilides:
Preemergence
grass
control
(
60%)

Imazethapyr:
Preemergence
and
Postemergence
broadleaf
and
grass
control
(
4%)
Roundup
Ready
Corn:
Post
broad
 
spectrum
control
in
glyphosate
tolerant
corn
Isoxaflutole:
Preemergence
broadleaf
and
grass
control
(
8%)
0812B1GH
[
OVERLAYS]
33
Ametryn
SMART
Meeting:
Alternatives
In
Sugarcane
Ametryn
is
used
in
combination
or
sequentially
with
other
herbicides,

where
it
broadens
that
product's
spectrum,
and
enhances
its
postemergence
activity
on
both
grasses
and
broadleaves.
It
is
not
a
stand
alone
product
and
thus
"
alternatives"
are
not
appropriate,
but
rather
how
would
other
AIs
be
used
without
ametryn.

2,4­
D:
Used
for
postemergence
broadleaf
control.
Higher
rates
or
additional
applications
needed.

Atrazine:
Complete
application
flexibility.
Ametryn
contributes
to
postemergence
burndown
of
both
grasses
and
broadleaves.

Higher
atrazine
rates
needed
without
ametryn.

Diuron:
BL
and
GR
but
ametryn
adds
burndown
and
spectrum
of
large
seeded
BL
and
vines.
More
use
of
2,4­
D
and/
or
atrazine.
0812B1GH
[
OVERLAYS]
34
Ametryn
SMART
Meeting:

Uniqueness
of
Ametryn
Uniqueness:

­
Effective
on
problem
grasses,
broadleaves,
and
nutsedge
­
Primarily
post
use
but
also
effective
pre
at
higher
rates
­
Very
economical
for
delivered
efficacy
­
At
low
rates,
can
enhance
postemergence
activity
of
tank
 
mix
partners
Limitations:

­
Risk
of
crop
injury
(
corn
and
sugarcane)

­
Requires
specific
applications
procedures
to
prevent
corn
injury
­
Effective
alternatives
have
been
developed
in
corn
0812B1GH
[
OVERLAYS]
35
Ametryn
SMART
Meeting:
New
Data?

Syngenta
has
no
new
toxicology
or
chemical­
specific
exposure
monitoring
data
or
biomonitoring
data.
0812B1GH
[
OVERLAYS]
36
Ametryn
SMART
Meeting:
Outstanding
Product
Chemistry
Data
63­
14
Oxidizing/
Reducing
Action
EPA
response
to
Phase
2
Submission
said
this
product
specific
requirement
will
be
addressed
in
Phase
Five.

63­
15
Flammability,
63­
18
Viscosity,
and
63­
19
Miscibility
Same
comment
as
for
63­
14,
and
not
applicable
because
Ametryn
Technical
is
not
a
liquid.

63­
21
Dielectric
Breakdown
Voltage
Same
comment
as
63­
14,
and
not
applicable
because
Ametryn
Technical
is
not
a
liquid
to
be
used
around
electrical
equipment.
0812B1GH
[
OVERLAYS]
37
Hawaii
Use
Information
 
Crops
Not
Supported
Pineapple:

21,000
A*

Ametryn
preplant
@
0.5
 
2
lbs/
A
on
100%
acres
postplant
@
0.5
 
2
lbs/
A
on
97%
acres
8,900
A**

Ametryn
preplant
or
immediately
postplant
@
1.6
lbs/
A
typical
additional
postplant
applications
@
1.6
lbs/
A
typical,
prior
to
flower
induction,
with
160­
day
PHI
Bananas:

1,700
A
Ametryn
on
300
A
at
6
lbs/
A
with
maximum
of
18
lbs/
A/
yr
*
Crop
Profiles:
http://
pestdata.
ncsu.
edu/
cropprofiles/
docs/
hipineapples.
html
(
1998
acreage)

**
Pineapple
Growers
Association
of
Hawaii,
Aug
25,
2003
letter
to
Syngenta
0812B1GH
[
OVERLAYS]
38
Puerto
Rico
Crops
Not
Supported
Bananas
and
plantains
new
planting,
pre
emergence
6
lbs/
A
4­
6
months,
direct
application
to
needed
areas
4
lbs/
A
up
to
4
applications
per
year
Pineapple
after
planting
prior
to
emergence
4
lbs/
A
only
application