Document ID: EPA-HQ-OPPT-2003-0028-0002
Agency: epa
Document Type: Notice
Title: Forty-Third Report of the TSCA Interagency Testing Committee; Notice
Posted Date: 2003-07-10T04:00Z

Tuesday,

October
31,
2000
Part
IV
Environmental
Protection
Agency
Forty­
Third
Report
of
the
TSCA
Interagency
Testing
Committee;
Notice
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OPPT­
2003­
0028­
0002
RECEIVED
OPPT
NCIC
2003
JUL
10
7:
44AM
65234
Federal
Register
/
Vol.
65,
No.
211
/
Tuesday,
October
31,
2000
/
Notices
ENVIRONMENTAL
PROTECTION
AGENCY
[
OPPTS
 
41051;
FRL
 
6049
 
5]

Forty­
Third
Report
of
the
TSCA
Interagency
Testing
Committee
to
the
Administrator;
Receipt
of
Report
and
Request
for
Comments
AGENCY:
Environmental
Protection
Agency
(
EPA).
ACTION:
Notice.

SUMMARY:
The
Toxic
Substances
Control
Act
(
TSCA)
Interagency
Testing
Committee
(
ITC)
transmitted
its
Forty­
Third
Report
to
the
Administrator
of
the
EPA
on
November
19,
1998.
In
the
43rd
Report,
which
is
included
with
this
notice,
the
ITC
revised
the
TSCA
section
4(
e)
Priority
Testing
List
by
removing
9
High
Production
Volume
Chemicals
(
HPVCs),
7
alkylphenols,
and
2
octylphenol
ethoxylates.
The
ITC
is
also
asking
EPA
to
promulgate
a
TSCA
section
(
d)
reporting
rule
for
18
alkylphenols;
15
nonylphenol
ethoxylates;
3­
amino­
5­
mercapto­
1,2,4­
triazole;
glycoluril;
and
methylal
recommended
by
the
ITC
for
testing
in
several
previous
ITC
Reports.
There
are
no
recommended,
designated,
or
recommended
with
intent­
to­
designate
chemicals
or
chemical
groups
in
the
43rd
Report.
EPA
invites
interested
persons
to
submit
written
comments
on
the
Report.

DATES:
Comments,
identified
by
docket
control
number
OPPTS
 
41051,
must
be
received
on
or
before
November
30,
2000.

ADDRESSES:
Comments
may
be
submitted
by
mail,
electronically,
or
in
person.
Please
follow
the
detailed
instructions
for
each
method
as
provided
in
Unit
I.
of
the
SUPPLEMENTARY
INFORMATION.
To
ensure
proper
receipt
by
EPA,
it
is
imperative
that
you
identify
docket
control
number
OPPTS
 
41051
in
the
subject
line
on
the
first
page
of
your
response.

FOR
FURTHER
INFORMATION
CONTACT:
For
general
information
contact:
Barbara
Cunningham,
Acting
Director,
Environmental
Assistance
Division,
Office
of
Pollution
Prevention
and
Toxics
(
7408),
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460;
telephone
number:
(
202)
554
 
1404;
e­
mail
address:
TSCA­
Hotline@
epa.
gov.
For
technical
information
contact:
John
D.
Walker,
ITC
Executive
Director
(
7401),
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460;
telephone
number:
(
202)
260
 
1825;
fax:
(
202)
260
 
7895;
e­
mail
address:
walker.
johnd@
epa.
gov.
SUPPLEMENTARY
INFORMATION:

I.
General
Information
A.
Does
this
Action
Apply
to
Me?

This
action
is
directed
to
the
public
in
general.
It
may,
however,
be
of
particular
interest
to
you
if
you
manufacture
(
defined
by
statute
to
include
import)
any
of
the
chemicals
listed
and
you
may
be
identified
by
the
North
American
Industrial
Classification
System
(
NAICS)
codes
325
and
32411.
Because
this
action
is
directed
to
the
general
public
and
other
entities
may
also
be
interested,
the
Agency
has
not
attempted
to
describe
all
the
specific
entities
that
may
be
interested
in
this
action.
If
you
have
any
questions
regarding
the
applicability
of
this
action
to
a
particular
entity,
consult
the
person
listed
under
FOR
FURTHER
INFORMATION
CONTACT.

B.
How
Can
I
Get
Additional
Information,
Including
Copies
of
this
Document
or
Other
Related
Documents?

1.
Electronically.
You
may
obtain
electronic
copies
of
this
document,
and
certain
other
related
documents
that
might
be
available
electronically,
from
the
EPA
Internet
Home
Page
at
http://
www.
epa.
gov/.
To
access
this
document,
on
the
Home
Page
select
``
Laws
and
Regulations,''
``
Regulations
and
Proposed
Rules,''
and
then
look
up
the
entry
for
this
document
under
the
``
Federal
Register
 
Environmental
Documents.''
You
can
also
go
directly
to
the
Federal
Register
listings
at
http://
www.
epa.
gov/
fedrgstr/.
You
may
also
access
additional
information
about
the
ITC
and
the
TSCA
testing
program
through
the
web
site
for
the
Office
of
Prevention,
Pesticides
and
Toxic
Substances
(
OPPTS)
at
http://
www.
epa.
gov/
internet/
oppts/,
or
go
directly
to
the
ITC
Home
Page
at
http:/
/
www.
epa.
gov/
opptintr/
itc/.
2.
In
person.
The
Agency
has
established
an
official
record
for
this
action
under
docket
control
number
OPPTS
 
41051.
The
official
record
consists
of
the
documents
specifically
referenced
in
this
action,
any
public
comments
received
during
an
applicable
comment
period,
and
other
information
related
to
this
action,
including
any
information
claimed
as
Confidential
Business
Information
(
CBI).
This
official
record
includes
the
documents
that
are
physically
located
in
the
docket,
as
well
as
the
documents
that
are
referenced
in
those
documents.
The
public
version
of
the
official
record
does
not
include
any
information
claimed
as
CBI.
The
public
version
of
the
official
record,
which
includes
printed,
paper
versions
of
any
electronic
comments
submitted
during
an
applicable
comment
period,
is
available
for
inspection
in
the
TSCA
Nonconfidential
Information
Center,
North
East
Mall
Rm.
B
 
607,
Waterside
Mall,
401
M
St.,
SW.,
Washington,
DC.
The
Center
is
open
from
noon
to
4
p.
m.,
Monday
through
Friday,
excluding
legal
holidays.
The
telephone
number
for
the
Center
is
(
202)
260
 
7099.

C.
How
and
to
Whom
Do
I
Submit
Comments?
You
may
submit
comments
through
the
mail,
in
person,
or
electronically.
To
ensure
proper
receipt
by
EPA,
it
is
imperative
that
you
identify
docket
control
number
OPPTS
 
41051
in
the
subject
line
on
the
first
page
of
your
response.
1.
By
mail.
Submit
your
comments
to:
Document
Control
Office
(
7407),
Office
of
Pollution
Prevention
and
Toxics
(
OPPT),
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460.
2.
In
person
or
by
courier.
Deliver
your
comments
to:
OPPT
Document
Control
Office
(
DCO)
in
East
Tower
Rm.
G
 
099,
Waterside
Mall,
401
M
St.,
SW.,
Washington,
DC.
The
DCO
is
open
from
8
a.
m.
to
4
p.
m.,
Monday
through
Friday,
excluding
legal
holidays.
The
telephone
number
for
the
DCO
is
(
202)
260
 
7093.
3.
Electronically.
You
may
submit
your
comments
electronically
by
e­
mail
to:
oppt.
ncic@
epa.
gov,
or
mail
your
computer
disk
to
the
address
identified
above.
Do
not
submit
any
information
electronically
that
you
consider
to
be
CBI.
Electronic
comments
must
be
submitted
as
an
ASCII
file
avoiding
the
use
of
special
characters
and
any
form
of
encryption.
Comments
and
data
will
also
be
accepted
on
standard
disks
in
WordPerfect
6.1/
8
or
ASCII
file
format.
All
comments
in
electronic
form
must
be
identified
by
docket
control
number
OPPTS
 
41051.
Electronic
comments
may
also
be
filed
online
at
many
Federal
Depository
Libraries.

D.
How
Should
I
Handle
CBI
Information
That
I
Want
to
Submit
to
the
Agency?
Do
not
submit
any
information
electronically
that
you
consider
to
be
CBI.
You
may
claim
information
that
you
submit
to
EPA
in
response
to
this
document
as
CBI
by
marking
any
part
or
all
of
that
information
as
CBI.
Information
so
marked
will
not
be
disclosed
except
in
accordance
with
procedures
set
forth
in
40
CFR
part
2.
In
addition
to
one
complete
version
of
the
comment
that
includes
any
information
claimed
as
CBI,
a
copy
of
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Federal
Register
/
Vol.
65,
No.
211
/
Tuesday,
October
31,
2000
/
Notices
the
comment
that
does
not
contain
the
information
claimed
as
CBI
must
be
submitted
for
inclusion
in
the
public
version
of
the
official
record.
Information
not
marked
confidential
will
be
included
in
the
public
version
of
the
official
record
without
prior
notice.
If
you
have
any
questions
about
CBI
or
the
procedures
for
claiming
CBI,
please
consult
the
technical
person
listed
under
FOR
FURTHER
INFORMATION
CONTACT.

E.
What
Should
I
Consider
as
I
Prepare
My
Comments
for
EPA?

We
invite
you
to
provide
your
views
and
comments
on
the
ITC's
43rd
Report.
You
may
find
the
following
suggestions
helpful
for
preparing
your
comments:
1.
Explain
your
views
as
clearly
as
possible.
2.
Describe
any
assumptions
that
you
used.
3.
Provide
copies
of
any
technical
information
and/
or
data
you
used
that
support
your
views.
4.
Provide
specific
examples
to
illustrate
your
concerns.
5.
Make
sure
to
submit
your
comments
by
the
deadline
in
this
notice.
6.
To
ensure
proper
receipt
by
EPA,
be
sure
to
identify
the
docket
control
number
OPPTS
 
41051
in
the
subject
line
on
the
first
page
of
your
response.
You
may
also
provide
the
name,
date,
and
Federal
Register
citation.

II.
Background
The
Toxic
Substances
Control
Act
(
TSCA)
(
15
U.
S.
C.
2601
et
seq.)
authorizes
the
Administrator
of
the
EPA
to
promulgate
regulations
under
section
4(
a)
requiring
testing
of
chemicals
and
chemical
groups
in
order
to
develop
data
relevant
to
determining
the
risks
that
such
chemicals
and
chemical
groups
may
present
to
health
or
the
environment.
Section
4(
e)
of
TSCA
established
the
ITC
to
recommend
chemicals
and
chemical
groups
to
the
Administrator
of
the
EPA
for
priority
testing
consideration.
Section
4(
e)
of
TSCA
directs
the
ITC
to
revise
the
TSCA
section
4(
e)
Priority
Testing
List
at
least
every
6
months.
EPA
has
received
the
TSCA
ITC's
43rd
Report
to
the
Administrator.
The
most
recent
revisions
to
the
Priority
Testing
List
are
included
in
the
ITC's
43rd
Report.
The
Report
was
received
by
the
EPA
Administrator
on
November
19,
1998,
and
is
included
in
this
notice.
The
ITC
revised
the
TSCA
section
4(
e)
Priority
Testing
List
by
removing
9
HPVCs
that
were
recommended
in
the
36th
Report
(
60
FR
42982,
August
17,
1995)
(
FRL
 
4965
 
6)
and
7
alkylphenols
and
2
octylphenol
ethoxylates
that
were
recommended
in
the
37th
Report
(
61
FR
4188,
February
2,
1996)
(
FRL
 
4991
 
6).
The
ITC
is
also
asking
EPA
to
promulgate
a
TSCA
section
8(
d)
reporting
rule
for
15
nonylphenol
ethoxylates
that
were
recommended
in
the
39th
Report
(
62
FR
8578,
February
25,
1997)
(
FRL
 
5580
 
9),
18
alkylphenols
that
were
recommended
in
the
41st
Report
(
63
FR
17658,
April
8,
1998)
(
FRL
 
5773
 
5),
and
3­
amino­
5­
mercapto­
1,2,4­
triazole;
glycoluril;
and
methylal
that
were
recommended
in
the
42nd
Report
(
63
FR
42553,
August
7,
1998)
(
FRL
 
5797
 
8)
to
determine
if
there
are
unpublished
data
to
meet
previously
determined
U.
S.
Government
data
needs.
1.
Promulgation
of
a
TSCA
section
8(
d)
reporting
rule.
The
ITC's
Voluntary
Information
Submissions
Innovative
Online
Network
(
VISION)
is
accessible
through
the
world
wide
web
(
http://
www.
epa.
gov/
opptintr/
itc/
vision.
htm)
and
is
designed
to
promote
more
efficient
use
of
TSCA
section
8
resources
through
submission
of
electronic
information.
As
part
of
VISION,
the
Voluntary
Information
Submission
Policy
clearly
states
that
if
the
ITC
does
not
receive
voluntary
electronic
information
submissions
to
meet
the
data
needs
for
recommended
chemicals,
then
it
will
ask
the
EPA
to
promulgate
a
TSCA
section
8(
d)
reporting
rule
to
determine
if
there
are
unpublished
studies
to
meet
those
data
needs.
The
EPA
is
being
asked
to
promulgate
a
TSCA
section
8(
d)
reporting
rule
for
the
chemicals
referenced
in
this
unit,
because
studies
submitted
to
the
VISION
did
not
adequately
meet
the
data
needs
for
those
chemicals.
The
ITC
is
requesting
that
the
EPA
promulgate
a
TSCA
section
8(
d)
reporting
rule
to
meet
only
those
data
needs
listed
in
certain
previous
ITC
Reports.
2.
Data
needs
 
i.
Nonylphenol
ethoxylates
and
alkylphenols.
Data
needs
for
15
nonylphenol
ethoxylates
recommended
in
the
39th
ITC
Report
and
18
alkylphenols
recommended
in
the
41st
ITC
Report
are
identical
and
are
listed
in
this
unit
as
they
were
expressed
in
the
41st
ITC
Report:
a.
Fish
and
amphibian
multigeneration
reproductive
effects
data.
b.
Avian
acute
toxicity
data
(
oral
feeding
and
egg
exposure
studies).
c.
Avian
reproductive
effects
data.
d.
Fish
and
wildlife
studies
data.
e.
Bioaccumulation
or
bioavailability
data.
f.
Health
effects
data,
including
absorption,
toxicokinetics,
systemic
toxicity,
endocrine
disruption,
reproductive
effects,
and
carcinogenicity
data.
ii.
3­
Amino­
5­
mercapto­
1,2,4­
triazole.
Data
needs
for
3­
amino­
5­
mercapto­
1,2,4­
triazole
are
listed
in
this
unit
as
they
were
expressed
in
the
42nd
ITC
Report:
Health
effects.
iii.
Glycoluril.
Data
needs
for
glycoluril
are
listed
in
this
unit
as
they
were
expressed
in
the
42nd
Report:
Health
effects.
iv.
Methylal.
Data
needs
for
methylal
are
listed
in
this
unit
as
they
were
expressed
in
the
42nd
Report:
Health
effects,
especially,
in
vivo
mammalian
metabolism
and
chronic
effects.
3.
Status
of
the
Priority
Testing
List.
The
TSCA
section
4(
e)
Priority
Testing
List
as
of
November
1998
can
be
found
in
Table
1
of
the
43rd
ITC
Report
which
is
included
in
this
notice.

List
of
Subjects
Environmental
protection,
Chemicals,
Hazardous
substances.

Dated:
October
24,
2000.
Charles
M.
Auer,
Director,
Chemical
Control
Division,
Office
of
Pollution
Prevention
and
Toxics.

Forty­
Third
Report
of
the
TSCA
Interagency
Testing
Committee
to
the
Administrator,
U.
S.
Environmental
Protection
Agency
Table
of
Contents
Summary
I.
Background
II.
TSCA
Section
8
Reporting
A.
TSCA
Section
8
Rules
B.
ITC's
Use
of
TSCA
Section
8
and
``
Other
Information''
C.
Promoting
More
Efficient
Use
of
Information
Submission
Resources
D.
Request
to
Promulgate
a
TSCA
Section
8(
d)
Rule
E.
Chemicals
for
Which
the
ITC
is
Requesting
That
EPA
Promulgate
a
TSCA
Section
8(
d)
Rule
III.
ITC's
Dialogue
Group
Activities
During
This
Reporting
Period
(
May
to
November
1998)
IV.
Revisions
to
the
TSCA
Section
4(
e)
Priority
Testing
List
A.
Summary
Table
of
Changes
B.
Chemicals
Removed
From
the
Priority
Testing
List
V.
TSCA
Interagency
Testing
Committee
Summary
This
is
the
43rd
Report
of
the
TSCA
Interagency
Testing
Committee
(
ITC)
to
the
Administrator
of
the
U.
S.
Environmental
Protection
Agency
(
EPA).
In
this
Report,
the
ITC
is
revising
its
TSCA
section
4(
e)
Priority
Testing
List
by
removing
9
High
Production
Volume
Chemicals
(
HPVCs),
7
alkylphenols,
and
2
octylphenol
ethoxylates.
In
this
Report,
the
ITC
is
also
asking
EPA
to
promulgate
a
TSCA
section
8(
d)
Health
and
Safety
Data
Reporting
(
HaSD)
rule
for
18
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alkylphenols,
15
nonylphenol
ethoxylates,
3­
amino­
5­
mercapto­
1,2,4­
triazole,
glycoluril,
and
methylal
to
determine
if
there
are
unpublished
data
to
meet
previously
determined
U.
S.
Government
data
needs.
The
revised
TSCA
section
4(
e)
Priority
Testing
List
follows
as
Table
1.

TABLE
1.
 
THE
TSCA
SECTION
4(
E)
Priority
Testing
List
(
NOVEMBER
1998)
1
Report
Date
Chemical/
Group
Action
26
.........................
May
1990
...........................
8
Isocyanates
..................................................
Recommended
with
intent­
to­
designate
27
.........................
November
1990
.................
62
Aldehydes
..................................................
Recommended
with
intent­
to­
designate
28
.........................
May
1991
...........................
Chemicals
with
Low
Confidence
Reference
Dose
(
RfD).
Acetone
Thiophenol
Designated
30
.........................
May
1992
...........................
5
Siloxanes
.....................................................
Recommended
31
.........................
January
1993
.....................
24
Chemicals
with
insufficient
dermal
absorption
rate
data.
Designated
32
.........................
May
1993
...........................
32
Chemicals
with
insufficient
dermal
absorption
rate
data.
Designated
35
.........................
November
1994
.................
24
Chemicals
with
insufficient
dermal
absorption
rate
data.
Designated
37
.........................
November
1995
.................
16
Alkylphenols
and
3
alkylphenol
polyethoxylates.
Recommended
39
.........................
November
1996
.................
15
Nonylphenol
ethoxylates
and
8
alkylphenol
polyethoxylates.
Recommended
41
.........................
November
1997
.................
18
Alkylphenols,
5
polyalkyphenols,
and
6
alkylphenol
polyethoxylates.
Recommended
42
.........................
May
1998
...........................
3­
Amino­
5­
mercapto­
1,2,4­
triazole
.................
Recommended
42
.........................
May
1998
...........................
Glycoluril
.........................................................
Recommended
42
.........................
May
1998
...........................
Methylal
...........................................................
Recommended
42
.........................
May
1998
...........................
Ethyl
silicate2
...................................................
Recommended
1
The
Priority
Testing
List
is
available
from
the
ITC's
web
site
(
http://
www.
epa.
gov/
opptintr/
itc).
2
Data
requested
through
the
ITC's
Voluntary
Information
Submissions
Innovative
Online
Network
(
VISION)
(
see
http://
www.
epa.
gov/
opptintr/
itc/
vision.
htm).

I.
Background
The
ITC
was
established
by
section
4(
e)
of
the
Toxic
Substances
Control
Act
(
TSCA)
``
to
make
recommendations
to
the
Administrator
respecting
the
chemical
substances
and
mixtures
to
which
the
Administrator
should
give
priority
consideration
for
the
promulgation
of
a
rule
for
testing
under
section
4(
a)....
At
least
every
six
months...,
the
Committee
shall
make
such
revisions
to
the
Priority
Testing
List
as
it
determines
to
be
necessary
and
transmit
them
to
the
Administrator
together
with
the
Committee's
reasons
for
the
revisions''
(
Public
Law
94
 
469,
90
Stat.
2003
et
seq.
(
15
U.
S.
C.
2601
et
seq.)).
Since
its
creation
in
1976,
the
ITC
has
submitted
42
semi­
annual
(
May
and
November)
Reports
to
the
EPA
Administrator
transmitting
the
Priority
Testing
List
and
its
revisions.
In
1989,
the
ITC
began
recommending
chemical
substances
for
information
reporting,
screening,
and
testing
to
meet
the
data
needs
of
its
member
U.
S.
Government
organizations.
ITC
Reports
are
available
from
http://
www.
epa.
gov/
opptintr/
itc/
within
a
few
days
of
submission
to
the
Administrator
and
from
http://
www.
epa.
gov/
fedrgstr/
after
publication
in
the
Federal
Register.
The
ITC
meets
monthly
and
produces
its
revisions
to
the
List
with
administrative
and
technical
support
from
the
ITC
staff
and
contract
support
provided
by
EPA.
ITC
members
and
staff
are
listed
at
the
end
of
this
Report.

II.
TSCA
Section
8
Reporting
A.
TSCA
Section
8
Rules
Following
receipt
of
the
ITC's
Report
by
the
EPA
Administrator
and
addition
of
chemicals
to
the
Priority
Testing
List,
the
EPA's
Office
of
Pollution
Prevention
and
Toxics
(
OPPT)
promulgates
TSCA
section
8(
a)
Preliminary
Assessment
Information
Reporting
(
PAIR)
and
TSCA
section
8(
d)
HaSD
Reporting
rules
for
chemicals
added
to
the
Priority
Testing
List.
These
rules
require
producers
and
importers
of
chemicals
recommended
by
the
ITC
to
submit
production
and
exposure
reports
under
TSCA
section
8(
a)
and
producers,
importers,
and
processors
of
chemicals
recommended
by
the
ITC
to
submit
unpublished
health
and
safety
studies
under
TSCA
section
8(
d).
These
rules
are
automatically
promulgated
by
OPPT
unless
requested
not
to
do
so
by
the
ITC.

B.
ITC's
Use
of
TSCA
Section
8
and
``
Other
Information''

The
ITC
reviews
the
TSCA
section
8(
a)
PAIR
reports,
TSCA
section
8(
d)
HaSD
studies,
and
``
other
information''
that
becomes
available
after
the
ITC
adds
chemicals
to
the
Priority
Testing
List.
``
Other
information''
includes
TSCA
section
4(
a)
and
4(
d)
studies,
TSCA
section
8(
c)
submissions,
TSCA
section
8(
e)
``
substantial
risk''
notices,
``
For
Your
Information''
(
FYI)
submissions,
ITC
voluntary
submissions,
unpublished
data
submitted
to
U.
S.
Government
organizations
represented
on
the
ITC,
published
papers,
as
well
as
use,
exposure,
effects,
and
persistence
data
that
are
voluntarily
submitted
to
the
ITC
by
manufacturers,
importers,
processors,
and
users
of
chemicals
recommended
by
the
ITC.
The
ITC
reviews
this
information
and
determines
if
data
needs
should
be
revised,
if
chemicals
should
be
removed
from
the
Priority
Testing
List
or
if
recommendations
should
be
changed
to
designations.

C.
Promoting
More
Efficient
Use
of
Information
Submission
Resources
The
Voluntary
Information
Submissions
Innovative
Online
Network
(
VISION)
is
accessible
through
the
world
wide
web
(
http://
www.
epa.
gov/
opptintr/
itc/
vision.
htm).
VISION
is
the
vehicle
that
is
used
to
promote
more
efficient
use
of
resources
through
submission
of
electronic
information.
VISION
currently
includes
the
Voluntary
Information
Submissions
Policy
(
VISP),
links
to
the
TSCA
Electronic
HaSD
Reporting
Form
(
http://
cyber22.
dcoirm.
epa.
gov/
oppt/

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tsca.
nsf/
HaSDForm?
openform)
and
instructions
for
the
Form
(
http://
www.
epa.
gov/
opptintr/
itc/
tscahlp
htm).
The
VISP
provides
examples
of
data
needed
by
ITC
member
U.
S.
Government
organizations,
examples
of
studies
that
should
not
be
submitted,
the
60­,
90­,
and
120­
day
milestones
for
meeting
the
objectives
of
the
VISP,
guidelines
for
using
the
TSCA
Electronic
HaSD
Reporting
Form,
and
instructions
for
electronically
submitting
full
studies.
The
TSCA
Electronic
HaSD
Reporting
Form
is
used
to
provide
electronic
information
on
ITC
and
TSCA
section
8(
d)
studies
(
to
meet
data
needs
of
the
ITC
member
U.
S.
Government
organizations),
FYI,
and
TSCA
section
8(
e)
studies,
and
studies
to
meet
the
needs
of
the
HPV
Chemical
Challenge
Program
(
http://
www.
epa.
gov/
opptintr/
chemtest/
hpv.
htm).

D.
Request
to
Promulgate
a
TSCA
Section
8(
d)
Rule
The
ITC
encourages
producers,
importers,
processors,
and
users
of
its
recommended
chemicals
to
use
VISION
to
voluntarily
provide
electronic
information
and
establish
a
dialogue
with
the
ITC
to
discuss
needed
data.
As
part
of
VISION,
the
VISP
clearly
states
that
if
the
ITC
does
not
receive
voluntary
electronic
information
submissions
to
meet
its
data
needs,
then
it
will
ask
the
EPA
to
promulgate
a
TSCA
section
8(
d)
HaSD
rule
to
determine
if
there
are
unpublished
data
to
meet
those
needs.
As
noted
in
Unit
2.
C.
of
this
Report,
the
TSCA
Electronic
HaSD
Reporting
Form
is
used
to
provide
electronic
information
on
TSCA
section
8(
d)
studies.
The
ITC
strongly
encourages
those
companies
that
must
respond
to
a
TSCA
section
8(
d)
rule
to
provide
only
the
data
requested
by
the
ITC
and
to
provide
data
by
using
the
TSCA
Electronic
HaSD
Reporting
Form.
At
this
time,
the
ITC
is
requesting
that
the
EPA
promulgate
a
TSCA
section
8(
d)
rule
for
several
chemicals
with
the
understanding
that
submissions
that
were
voluntarily
provided
as
ITC
submissions,
do
not
have
to
be
resubmitted
under
the
TSCA
section
8(
d)
HaSD
rule.
The
ITC
is
requesting
that
the
EPA
promulgate
a
TSCA
section
8(
d)
HaSD
rule
to
meet
only
those
data
needs
listed
in
previous
ITC
Reports.

E.
Chemicals
for
Which
the
ITC
is
Requesting
That
EPA
Promulgate
a
TSCA
Section
8(
d)
Rule
1.
39th
and
41st
Report
chemicals.
The
ITC
considered
structures
and
annual
production
and
importation
volumes
for
nonylphenol
ethoxylates
and
nonylphenol
polyethoxylates
recommended
in
the
39th
Report
(
62
FR
8578,
February
25,
1997)
(
FRL
 
5580
 
9)
and
for
alkylphenols,
polyalkylphenols,
and
alkylphenol
polyethoxylates
recommended
in
the
41st
Report
(
63
FR
17658,
April
9,
1998)
(
FRL
 
5773
 
5).
In
addition,
the
ITC
considered
use
and
health
and
safety
data
voluntarily
submitted
to
the
ITC
by
the
Chemical
Manufacturers
Association
(
CMA)
Alkylphenols
and
Ethoxylates
(
AP&
E)
Panel
before
VISION
was
developed,
health
and
safety
data
voluntarily
submitted
through
VISION
as
well
as
TSCA
section
8(
d)
health
and
safety
data
submitted
for
structurally
related
chemicals
in
the
37th
Report
(
61
FR
4188,
February
2,
1996)
(
FRL
 
4991
 
6).
After
considering
this
information,
and
determining
that
it
was
not
adequate
to
meet
the
data
needs
for
these
chemicals,
the
ITC
decided
to
ask
EPA
to
promulgate
a
TSCA
section
8(
d)
HaSD
rule
for
the
nonylphenol
ethoxylates
recommended
in
the
39th
Report
and
the
alkylphenols
recommended
in
the
41st
Report.
These
chemicals
are
listed
in
Table
2.
2.
42nd
Report
chemicals.
The
ITC
sent
its
42nd
Report
(
63
FR
42554,
August
7,
1998)
(
FRL
 
5797
 
8)
to
manufacturers
of
3­
amino­
5­
mercapto­
1,2,4­
triazole,
glycoluril,
and
methylal
and
requested
that
they
use
VISION
to
provide
data
to
meet
the
U.
S.
Government
data
needs
described
in
the
42nd
Report.
Since
no
information
to
meet
these
data
needs
was
received,
the
ITC
is
asking
EPA
to
promulgate
a
TSCA
section
8(
d)
HaSD
rule
for
these
chemicals
to
determine
if
there
are
unpublished
data
to
meet
those
needs.
The
ITC
also
contacted
the
Silicones
Environmental
Health
and
Safety
Council
(
SEHSC)
about
providing
data
for
ethyl
silicate.
The
SEHSC
agreed
to
meet
with
the
ITC
to
discuss
data
needs.
If
needed
data
are
not
provided,
the
ITC
will
consider
asking
EPA
to
promulgate
a
TSCA
section
8(
d)
HaSD
rule
for
ethyl
silicate.

TABLE
2.
 
CHEMICALS
FOR
WHICH
THE
ITC
IS
REQUESTING
THAT
EPA
PROMULGATE
A
TSCA
SECTION
8(
D)
HASD
RULE
CAS
No.
Chemical
name
ITC
Report
describing
U.
S.
Government
data
needs
Pentylphenols
.
136
 
81
 
2
.......................
Phenol,
2­
pentyl­
........................................................................................................
41
3279
 
27
 
4
.....................
Phenol,
2­(
1,1­
dimethylpropyl)­
..................................................................................
41
25735
 
67
 
5
...................
Phenol,
4­
sec­
pentyl­
.................................................................................................
41
26401
 
74
 
1
...................
Phenol,
2­
sec­
pentyl­
.................................................................................................
41
Hexylphenols
.
2446
 
69
 
7
.....................
Phenol,
4­
hexyl­
.........................................................................................................
41
Heptylphenols
.
1987
 
50
 
4
.....................
Phenol,
4­
heptyl­
........................................................................................................
41
72624
 
02
 
3
...................
Phenol,
heptyl
derivs.
.................................................................................................
41
84605
 
25
 
4
...................
Phenol,
1­
methylhexyl
derivs.
....................................................................................
41
Octylphenols
.
140
 
66
 
9
.......................
Phenol,
4(
1,1,3,3­
tetramethylbutyl)
............................................................................
41
71902
 
25
 
5
...................
Phenol,
octenylated
....................................................................................................
41
Nonylphenols
.
68081
 
86
 
7
...................
Phenol,
nonyl
derivs.
..................................................................................................
41
91672
 
41
 
2
...................
Phenol,
2­
nonyl­,
branched
........................................................................................
41
Decylphenols
.
27157
 
66
 
0
...................
Phenol,
tetradecyl­
.....................................................................................................
41
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TABLE
2.
 
CHEMICALS
FOR
WHICH
THE
ITC
IS
REQUESTING
THAT
EPA
PROMULGATE
A
TSCA
SECTION
8(
D)
HASD
RULE
 
Continued
CAS
No.
Chemical
name
ITC
Report
describing
U.
S.
Government
data
needs
Dodecylphenols
.
74499
 
35
 
7
...................
Phenol,
(
tetrapropenyl)
derivs.
...................................................................................
41
Tetradecylphenols
.
70682
 
80
 
3
...................
Phenol,
tetradecyl­
.....................................................................................................
41
Hexadecylphenols
.
2589
 
78
 
8
.....................
Phenol,
hexadecyl
......................................................................................................
41
25401
 
86
 
9
...................
Phenol,
2­
hexadecyl­
..................................................................................................
41
Other
Alkylphenols
.
68784
 
24
 
7
...................
Phenol,
C18­
30­
alkyl
derivs.
......................................................................................
41
Nonylphenol
Ethoxylates
.
7311
 
27
 
5
.....................
Ethanol,
2­[
2­[
2­[
2­(
4­
nonylphenoxy)
ethoxy]
ethoxy]
ethoxy]­
......................................
39
20427
 
84
 
3
...................
Ethanol,
2­[
2­(
4­
nonylphenoxy)
ethoxy]
......................................................................
39
20636
 
48
 
0
...................
3,6,9,12­
Tetraoxatetradecan­
1­
ol,
14­(
4­
nonylphenoxy)
............................................
39
26264
 
02
 
8
...................
3,6,9,12­
Tetraoxatetradecan­
1­
ol,
14­(
nonylphenoxy)­
..............................................
39
26571
 
11
 
9
...................
3,6,9,12,15,18,21,24­
Octaoxahexacosan­
1­
ol,
26­(
nonylphenoxy)­
..........................
39
27176
 
93
 
8
...................
Ethanol,
2­[
2­(
nonylphenoxy)
ethoxy]­
........................................................................
39
27177
 
01
 
1
...................
3,6,9,12,15­
Pentaoxaheptadecan­
1­
ol,
17­(
nonylphenoxy)­
......................................
39
27177
 
05
 
5
...................
3,6,9,12,15,18,21­
Heptaoxatricosan­
1­
ol,
23­(
nonylphenoxy)
...................................
39
27177
 
08
 
8
...................
3,6,9,12,15,18,21,24,27­
Nonaoxanonacosan­
1­
ol,
29­(
nonylphenoxy)­
....................
39
27986
 
36
 
3
...................
Ethanol,
2­(
nonylphenoxy)­
........................................................................................
39
65455
 
72
 
3
...................
3,6,9,12,15,18,21,24,27­
Nonaoxanonacosan­
1­
ol,
29­(
isononylphenoxy)­
...............
39
98113
 
10
 
1
...................
Nonoxynol­
9
...............................................................................................................
39
NA1
................................
Nonoxynol­
2
...............................................................................................................
39
NA1
................................
Nonoxynol­
3
...............................................................................................................
39
NA1
................................
Nonoxynol­
7
...............................................................................................................
39
Other
Chemicals
.
109
 
87
 
5
.......................
Methylal
......................................................................................................................
42
496
 
46
 
8
.......................
Glycoluril
.....................................................................................................................
42
16691
 
43
 
3
...................
3­
Amino­
5­
mercapto­
1,2,4­
triazole
.............................................................................
42
1Not
available
III.
ITC's
Dialogue
Group
Activities
During
This
Reporting
Period
(
May
to
November
1998)

The
CMA
 
ITC
AP&
E
Dialogue
Group
was
formed
by
the
CMA's
AP&
E
Panel
and
the
ITC's
AP&
E
Subcommittee
in
March
1996
following
the
submission
of
the
ITC's
37th
Report
to
the
EPA
Administrator
in
November
1995.
The
Group
was
created
to
facilitate
the
ITC's
retrieval
of
information
on
uses,
exposures,
and
health
and
ecological
effects
of
alkylphenols
and
alkylphenol
ethoxylates,
and
the
Panel's
understanding
of
data
needed
by
the
U.
S.
Government
organizations
represented
on
the
Subcommittee.
Since
the
creation
of
this
Dialogue
Group,
numerous
activities
have
occurred:
See
the
ITC's
38th
Report
(
61
FR
39832,
July
30,
1996)
(
FRL
 
5379
 
2);
39th
Report;
40th
Report
(
62
FR
30580,
June
4,
1997)
(
FRL
 
5718
 
3);
41st
Report,
and
42nd
Report.
After
the
42nd
Report
was
delivered
to
the
EPA
Administrator,
some
members
of
the
CMA's
AP&
E
Panel
formed
the
APE
Research
Council
(
APERC).
The
APERC­
ITC
AP&
E
Dialogue
Group
met
twice
during
this
reporting
period.
On
August
12
and
October
15,
1998,
the
Dialogue
Group
met
to
discuss:
1.
Status
of
TSCA
section
8(
a)
PAIR
and
TSCA
section
8(
d)
rules
for
the
39th
and
41st
ITC
Reports.
2.
Number
and
type
of
studies
on
alkylphenols
and
alkylphenol
ethoxylates
sent
to
VISION.
3.
Status
of
research
related
to
U.
S.
Government
data
needs
for
alkylphenols
and
alkylphenol
ethoxylates
(
e.
g.,
multigeneration
fish
studies
to
determine
offspring
reproductive
capabilities).
4.
Progress
and
results
of
ongoing
environmental
and
toxicological
studies
being
conducted
or
sponsored
by
chemical
manufacturers
on
the
Council,
(
e.
g.,
mammalian
in
vitro
and
in
vivo
toxicology,
mammalian
pharmacokinetic,
biodegradation,
aquatic
toxicity,
and
avian
acute
toxicity
studies).
5.
Organization
for
Economic
Cooperation
and
Development
(
OECD)
Screening
Information
Data
Set
(
SIDS)
dossiers
on
nonylphenol
and
nonylphenol
ethoxylates.
6.
Alkylphenols
that
may
be
removed
from
the
Priority
Testing
List.
7.
Alkylphenols
and
nonylphenol
ethoxylates
being
considered
for
Quantitative
Structure
Activity
Relationship
(
QSAR)
studies.

IV.
Revisions
to
the
TSCA
Section
4(
e)
Priority
Testing
List
A.
Summary
Table
of
Changes
Revisions
to
the
TSCA
section
4(
e)
Priority
Testing
List
are
summarized
in
Table
3.

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Notices
TABLE
3.
 
REVISIONS
TO
THE
TSCA
SECTION
4(
E)
Priority
Testing
List
CAS
No.
Chemical
name
Action
Date
Remove
November
1998
........................
HPVCs
..................................................
80
 
51
 
3
.............
p,
p'­
Oxybis(
benzenesulfonylhydrazide)
....................
do.
do.
81
 
84
 
5
.............
Naphthalenedicarboxylic
anhydride
.........................
do.
do.
99
 
54
 
7
.............
3,4­
Dichloronitrobenzene
.........................................
do.
do.
100
 
29
 
8
...........
4­
Ethoxynitrobenzene
...............................................
do.
do.
119
 
33
 
5
...........
4­
Methyl­
2­
nitrophenol
..............................................
do.
do.
121
 
60
 
8
...........
4­(
Acetylamino)
benzenesulfonyl
chloride
...............
do.
do.
626
 
17
 
5
...........
1,3­
Dicyanobenzene
.................................................
do.
do.
929
 
06
 
6
...........
2­(
2­
Aminoethoxy)
ethanol
.......................................
do.
do.
3089
 
11
 
0
.........
Hexa(
methoxymethyl)
melamine
..............................
do.
do.
Butylphenols
3180
 
09
 
4
.........
2­
Butylphenol
............................................................
do.
do.
27178
 
34
 
3
.......
tert­
Butylphenol
mixed
isomers
................................
do.
do.
........................
Pentylphenols
94
 
06
 
4
.............
4­(
1­
Methylbutyl)
phenol
............................................
do.
do.
Octylphenols
949
 
13
 
3
...........
2­
Octylphenol
...........................................................
do.
do.
27985
 
70
 
2
.......
(
1­
Methylheptyl)
phenol
.............................................
do.
do.
........................
Nonylphenols
11066
 
49
 
2
.......
Isononylphenol
(
mixed
isomers)
..............................
do.
do.
17404
 
66
 
9
.......
4­(
1­
Methyloctyl)
phenol
............................................
do.
do.
........................
Octylphenol
Ethoxylates
2315
 
66
 
4
.........
Decaethylene
glycol
4­
isooctylphenyl
ether
.............
do.
do.
2497
 
58
 
7
.........
Hexaethylene
glycol
4­
isooctylphenyl
ether
.............
do.
do.

B.
Chemicals
Removed
From
the
Priority
Testing
List
1.
HPVCs
 
a.
Rationale.
The
ITC
is
removing
9
HPVCs
(
Table
3)
from
the
Priority
Testing
List
because:
i.
EPA,
CMA,
and
the
Environmental
Defense
Fund
have
agreed,
that
by
the
year
2003,
data
will
be
provided
or
developed
for
about
3,000
HPVCs
produced
or
imported
into
the
United
States.
ii.
The
3,000
HPVCs
includes
the
9
HPVCs
on
the
Priority
Testing
List.
iii.
At
this
time,
there
are
no
specific
U.
S.
Government
data
needs
for
these
chemicals
that
would
not
be
met
by
the
HPV
Chemical
Challenge
Program.
b.
Supporting
information.
HPVCs
are
chemicals
with
annual
domestic
production
or
importation
volumes
greater
than
1
million
pounds.
Information
on
ITC's
review
of
HPVCs
is
contained
in
Reports
27th
(
56
FR
9534,
March
6,
1991)
(
FRL
 
3845
 
3),
35th
(
59
FR
67596,
December
29,
1994)
(
FRL
 
4923
 
2),
36th
(
60
FR
42982,
August
17,
1995)
(
FRL
 
4965
 
6),
37th,
38th,
and
40th.
The
``
Screening
Information
Data
Set
(
SIDS)
Manual
of
the
OECD
Programme
on
the
Co­
operative
Investigation
of
High
Production
Volume
Chemicals,''
provides
test
guidance
for
developing
data
for
HPVCs.
The
basic
screening
endpoints
are
listed
in
section
2.2
(
page
2)
of
this
Manual
(
the
``
SIDS
Manual;''
available
at
http://
www.
epa.
gov/
opptintr/
sids/
sidsman.
htm).
2.
Alkylphenols
and
alkylphenol
ethoxylates
 
a.
Rationale.
The
ITC
is
removing
2
butylphenols,
1
pentylphenol,
2
octylphenols,
2
nonylphenols,
and
2
octylphenol
ethoxylates
(
Table
3)
from
the
Priority
Testing
List
because
no
domestic
production
or
importation
volumes
were
reported
to
the
EPA
in
response
to
1986,
1990,
and
1994
Information
Update
Rules
(
indicating
that
volumes
were
less
than
10,000
pounds
per
site
in
1985,
1989,
and
1993),
no
domestic
production
or
importation
volumes
were
reported
to
the
EPA
in
response
to
the
February
28,
1996,
PAIR
rule
(
indicating
that
volumes
were
less
than
1,000
pounds
per
site
in
1995),
no
TSCA
section
8(
d)
studies
were
submitted
to
the
EPA
in
response
to
the
February
28,
1996,
HaSD
rule
and
because
no
TSCA
section
8(
e),
FYI,
or
ITC
studies
were
available
for
these
chemicals
as
of
September
1998.
b.
Supporting
information.
Information
on
the
ITC's
review
of
alkylphenols
and
alkylphenol
ethoxylates
is
contained
in
Reports
37,
38,
39,
40,
and
41.
The
ITC
reviewed
use
and
health
and
safety
data
voluntarily
submitted
to
the
ITC
by
the
CMA
 
ITC
AP&
E
Dialogue
Group
before
VISION
was
developed
and
health
and
safety
data
voluntarily
submitted
through
VISION.

V.
TSCA
Interagency
Testing
Committee
Statutory
Organizations
and
Their
Representatives
Council
on
Environmental
Quality
Brad
Campbell,
Member
Department
of
Commerce
National
Institute
of
Standards
and
Technology
Malcolm
W.
Chase,
Member
Barbara
C.
Levin,
Alternate
National
Oceanographic
and
Atmospheric
Administration
Nancy
Foster,
Member
Teri
Rowles,
Alternate
Richard
S.
Artz,
Alternate
Environmental
Protection
Agency
Paul
Campanella,
Member
David
R.
Williams,
Alternate
National
Cancer
Institute
Victor
Fung,
Member,
Chair
Harry
Seifried,
Alternate
National
Institute
of
Environmental
Health
Sciences
William
Eastin,
Member,
Vice
Chair
H.
B.
Matthews,
Alternate
National
Institute
for
Occupational
Safety
and
Health
Albert
E.
Munson,
Member
Christine
Sofge,
Alternate
National
Science
Foundation
A.
Frederick
Thompson,
Member
Joseph
Reed,
Alternate
Occupational
Safety
and
Health
Administration
Lyn
Penniman,
Member
Val
H.
Schaeffer,
Alternate
Liaison
Organizations
and
Their
Representatives
Agency
for
Toxic
Substances
and
Disease
Registry
William
Cibulas,
Member
Consumer
Product
Safety
Commission
Jacqueline
Ferrante,
Member
Department
of
Agriculture
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/
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31,
2000
/
Notices
;
Clifford
P.
Rice,
Member
Department
of
the
Interior
Barnett
A.
Rattner,
Member
Food
and
Drug
Administration
Edwin
J.
Matthews,
Member
Raju
Kammula,
Alternate
National
Library
of
Medicine
Vera
W.
Hudson,
Member
National
Toxicology
Program
NIEHS,
FDA,
and
NIOSH
Members
Counsel
Scott
Sherlock,
OPPT,
EPA
Technical
Support
Contractor
Syracuse
Research
Corporation
ITC
Staff
John
D.
Walker,
Executive
Director
Norma
S.
L.
Williams,
Executive
Assistant
TSCA
Interagency
Testing
Committee,
Office
of
Pollution
Prevention
and
Toxics
(
7401),
Environmental
Protection
Agency,
Ariel
Rios
Bldg.,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460;
telephone:
(
202)
260
 
1825;
fax:
(
202)
260
 
7895;
e­
mail
address:
williams.
norma@
epa.
gov;
url:
http://
www.
epa.
gov/
opptintr/
itc.

[
FR
Doc.
00
 
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Filed
10
 
30
 
00;
8:
45
am]

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