Document ID: EPA-HQ-OPP-2012-0590-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2013-09-11T04:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                            WASHINGTON, D.C.  20460

	
                                                                      OFFICE OF
                                                            CHEMICAL SAFETY AND
                                                           POLLUTION PREVENTION

MEMORANDUM

Date:		31-JUL-2013

            Subject:	Prometryn:  Acute and Chronic Dietary (Food and Drinking Water) Exposure and Risk Assessment to Support the Section 3 Registration Request For Use of Prometryn on Snap Beans and Dill.

PC Code:  080805
DP Barcode:  D408528
Decision No.:  467531
Registration No:  100-620  
Petition No.:  2E8052
Regulatory Action:  Amended Sec. 3
Risk Assessment Type:  Dietary 
Case No.:  0467
TXR No.:  NA
CAS No.:  7287-19-6
MRID No.:  None
40 CFR:  §180.222

From:		Sarah J. Levy, Chemist
      Risk Assessment Branch 1 (RAB1)/Health Effects Division (HED; 7509P)

Through:		William Cutchin, Chemist
		Ideliz Negron-Encarnacion, Ph.D., Chemist
            Dietary Exposure Science Advisory Council (DESAC)/HED (7509P)
                  and
            George F. Kramer, Ph.D., Branch Senior Scientist
            RAB1/HED (7509P)

         To:		Kelly M. Lowe, Risk Assessor
		RAB1/HED (7509P)

            and

      Barbara Madden, RM 05 
      Registration Division (RD; 7505P)
      
Executive Summary

Acute and chronic (food and drinking water) dietary-exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) Version 3.16, which uses food consumption data from the U.S. Department of Agriculture's National Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA) from 2003 through 2008.  The analyses were performed to support Section 3 use requests on snap beans and dill.  It should be noted that prometryn is already registered for use on dill; however, the current registration is limited to a regional registration.  The Registrant has submitted additional data to expand the regional registration to a national registration.  The proposed national use pattern is identical to the currently registered regional use pattern.  

These analyses have been reviewed by two peer reviewers of the DESAC, per the DESAC Standard Operating Procedure (SOP) 2012.1.

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization 
The acute analysis assumed 100% crop treated (CT), tolerance-level residues for all foods, and DEEM 7.81 default processing factors.  Dietary risk estimates were determined considering exposures from food plus drinking water using estimated drinking water concentrations (EDWCs) for surface water sources provided by the Environmental Fate and Effects Division (EFED).  An acute EDWC value was generated using the carrot use pattern as this use yielded the highest acute EDWC value, 377.4 ppb.  The acute assessment shows that the acute dietary risk estimate is not of concern to HED [i.e., <100% acute population-adjusted dose (aPAD)].  The resulting acute dietary (food + drinking water) risk estimates utilized 17% of the aPAD for the females 13-49 years old population subgroup, the only acute population subgroup of concern for this assessment.   

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization
The chronic analysis assumed 100% crop treated (CT), tolerance-level residues for all foods, and DEEM 7.81 default processing factors.  Dietary risk estimates were determined considering exposures from food plus drinking water using EDWCs for surface water sources provided by EFED.  A chronic EDWC value was generated using the carrot use pattern as this use yielded the highest chronic EDWC value, 157.9 ppb.  The assessment shows that the chronic dietary risk estimates are not of concern to HED [i.e., <100% chronic population-adjusted dose (cPAD)].  The resulting chronic dietary (food + drinking water) risk estimates utilized 8.6% of the cPAD for the general U.S. population and 23% of the cPAD for all infants (<1 year old), the most highly exposed population subgroup.   

Cancer 
A cancer dietary assessment was not conducted because prometryn is classified as "Group E: Evidence of non-carcinogenicity for humans."

I.  Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose that HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the population-adjusted dose (PAD).  The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  References that discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  "Available Information on Assessing Exposure from Pesticides, A User's Guide," 21-JUN-2000, web link:  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for prometryn was conducted on 08-AUG-2009 (Memo, W. Wassell; D367832).

II.  Residue Information

Prometryn is a substituted thiomethy triazine herbicide (Group 5) registered in the U.S. for the control of weeds in a number of commodities.  The Product and Residue Chemistry Chapters for the Prometryn RED were issued 08-DEC-1994.  

Residues of Concern:  HED previously determined that the residue of concern in plants consists of the parent, prometryn per se, which is the currently regulated residue.  HED concluded that if other major uses were registered in the future, additional metabolism studies would be required.  The petitioner recently submitted a metabolism study in rice which was reviewed as part of the following memorandum:  S. Levy, 13-MAR-2013; D398563.  Although the rice metabolism study was deemed adequate, it presents a qualitatively different metabolic profile than the celery and cotton profiles (Memo, C. Swartz, 05-DEC-1994; D208880 and 09-DEC-1995; D207139, respectively).  In the celery and cotton metabolism studies, parent was the major residue and in the rice metabolism study metabolite GS-17794 was the major residue.  Therefore, HED is still requesting a root crop metabolism study.  This deficiency remains outstanding.  Depending on results of the root crop metabolism study, additional field trial data could be required.

The nature of the residue in livestock is adequately understood based on acceptable poultry and ruminant metabolism studies.  The residue of concern (and that which should be regulated) in livestock is the parent, prometryn per se.  As in plants, the metabolism of prometryn in livestock involves N-dealkylation along with hydrolysis and/or amino acid conjugation.  The 1994 Residue Chemistry Chapter concluded that residues of prometryn per se in meat and milk can be classified under Category 3 of 40 CFR §180.6(a).  That is, there is no reasonable expectation of finite residues in meat and milk.  No tolerances were required in the Residue Chapter; therefore, livestock feeding studies were not required.  In the current petition, the only livestock feedstuff is cowpea, forage which may contribute up to 20% in dairy cow diets only.  In the previously constructed dietary burden, barley forage was included in the dairy cattle diet.  The established barley forage tolerance of 0.30 ppm is higher than the HED-recommended tolerance of 0.09 ppm associated with this petition; therefore, constructing a new dietary burden would result in a lower dietary burden.  Pending submission of an additional plant metabolism study, HED tentatively concludes that the Category 3 situation remains valid for this registration request.  

 For drinking water, EFED included parent only, as was done in previous risk assessments.  Modeling parent only is a high-end, conservative assumption.  EFED stated that their entire drinking water assessment for prometryn will be updated concurrent with registration review.

Established Tolerances:  Permanent tolerances for residues of prometryn per se are currently established in/on a variety of crops (40 CFR §180.222(a)).  There is also a tolerance with regional registration in/on dill as well as tolerances for indirect or inadvertent residues in/on hay, straw, and forage of barley, oat, rye, triticale, and wheat.

Recommended Tolerances:  Based on the residue chemistry data submitted with the current petition, HED recommended for establishment of the tolerances outlined below.  Furthermore, in accordance with the most recent guidance concerning tolerance expressions, HED recommends that the tolerance expression for 40 CFR §180.222 be changed as indicated below.
 
"(a) General.  Tolerances are established for residues of the herbicide prometryn, including its metabolites and degradates, in or on the commodities in the table below.  Compliance with the tolerance levels specified below is to be determined by measuring only prometryn [2,4-bis(isopropylamino)-6-methylthio-s-triazine] in or on the following raw agricultural commodities:"

            Snap, bean, succulent	0.05 ppm
            Dillweed, fresh leaves	0.30 ppm
            Dill, dried leaves	1.1 ppm

and

(d) Indirect or inadvertent residues.  Tolerances are established for indirect or inadvertent residues of the herbicide prometryn, including its metabolites and degradates, in or on the commodities in the table below.  Compliance with the tolerance levels specified below is to be determined by measuring only prometryn ([2,4-bis(isopropylamino)-6-methylthio-s-triazine] in or on the following raw agricultural commodities:"

Note that concurrent with the establishment of the HED-recommended tolerances for residues in/on dillweed, fresh leaves and dill, dried leaves, the established tolerance of 0.3 ppm in/on dill with regional restriction should be removed in 40 CFR §180.222(c).
   
Residue Data Used for Acute and Chronic Assessments:   These analyses utilized established and HED-recommended tolerance-level residues for all commodities and DEEM (ver. 7.81) default processing factors.
 
III.	Percent Crop Treated

Both the acute and chronic assessments utilized 100% CT for all commodities.  

IV.	Drinking Water Data

Drinking water residues were incorporated directly into the acute and chronic dietary analyses ("water, direct, all sources" and "water, indirect, all sources") and were provided by EFED (Memo, M. Ruhman, 13-MAR-2013; D403977).  The EDWCs were screening-level estimates generated with the Food Quality Protection Act (FQPA) Index Reservoir Screening Tool (FIRST) in surface water and with Screening Concentration in Ground Water (SCI-GROW) for ground water.  The driver for the EDWCs, for surface and ground water, was application to (previously registered use) carrots (three ground applications at 2 lbs a.i/A, 30 days apart).

Table 1.  Maximum Screening EDWCs of Prometryn for Current and Proposed Uses.
                         Drinking Water Source (model)
                           Use (Maximum Annual Rate)
           Upper-Bound Estimated Drinking Water Concentrations (ppb)

                             Acute (peak exposure)
                        Chronic (annual mean exposure)
Surface Water (FIRST)
Carrots (3 applications at 2 lb ai/A, 30 days apart)
                                     377.4
                                     157.9
Groundwater (SCI-GROW)
Carrots (3 applications at 2 lb ai/A, 30 days apart)
                                     23.4

Surface water EDWCs of 0.3774 ppm and 0.1579 ppm were used in the acute and chronic analyses, respectively, as these values were the highest and provided a more conservative approach.

IV.  DEEM-FCID Program and Consumption Information

Prometryn acute and chronic dietary exposure assessments were conducted using DEEM-FCID, Version 3.16, which incorporates consumption data from USDA's NHANES/WWEIA from 2003 through 2008.  The data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods "as consumed" (e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups.  However, for acute exposure assessment, consumption data are retained as individual consumption events.  Based on analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate.  The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

For an acute exposure assessment, individual one-day food consumption data are used on an individual-by-individual basis.  The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or "matched" in multiple random pairings with residue values and then summed in a probabilistic assessment.  The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis.  In accordance with HED policy, per capita exposure and risk are reported for analyses performed at all levels of refinement.  However, for deterministic assessments, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.
 
 V.  Toxicological Information
 
Table 2 summarizes the toxicological doses and endpoints for prometryn concerning dietary exposure assessment.  The endpoints have been reviewed by the risk assessment team and are considered appropriate for the current risk assessment.  

Table 2.  Summary of Toxicological Doses and Endpoints for Prometryn for Use in Dietary Human-Health Risk Assessments. 
                               Exposure Scenario
                              Point of Departure
                        Uncertainty/FQPA Safety Factors
                       RfD, PAD, LOC for Risk Assessment
                   Study and Relevant Toxicological Effects
Acute Dietary
(Females 13-49 years of age)
NOAEL = 12
mg/kg/day
UFA = 10X
UFH = 10X
UFFQPA = 1X 
aRfD = aPAD = 0.12 mg/kg/day
Developmental toxicity (rabbit)

LOAEL = 72 mg/kg based on increased incidence of resporptions, abortions, and post-implantation loss leading to decreased number of viable litters and live fetuses.
Chronic Dietary 
(All Populations)
NOAEL = 3.75
mg/kg/day
UFA = 10X
UFH = 10X
UFFQPA = 1X
cRfD = cPAD = 0.04 mg/kg/day
Chronic toxicity (dog; dietary)

LOAEL = 37.5 mg/kg/day based on degenerative hepatic changes, renal tubule degeneration, and bone marrow atrophy.
Cancer (Oral, Dermal, Inhalation)
Classification:  "Group E:  Evidence of non-carcinogenicity for humans."
Abbreviations:  UF = uncertainty factor, UFA = extrapolation from animal to human (interspecies), UFH = potential variation in sensitivity among members of the human population (intraspecies), UFFQPA = FQPA Safety Factor, NOAEL = no-observed adverse-effect level, LOAEL = lowest-observed adverse-effect level, RfD = reference dose (a = acute, c = chronic), PAD = population-adjusted dose, LOC = level of concern.

 VI.  Results/Discussion
 
For acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID analyses estimate the dietary exposure of the U.S. population and various population subgroups.  The results reported in Table 3 are for the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50-99 years.  

Results of Acute and Chronic Dietary Exposure Analyses
 
The resulting acute food plus drinking water risk estimates are not of concern to HED (<100% aPAD) at the 95[th] percentile of the exposure.  The resulting acute risk estimate is 17% of the aPAD of the exposure distribution for females 13 to 49 years old, the only acute population subgroup of concern for this assessment.

The resulting chronic exposure estimates are not of concern to HED.  The most highly exposed population was all infants (<1 year old) utilizing 23% of the cPAD (see Table 3 below for a summary of the results).  A chronic cancer dietary assessment was not conducted since it was determined that prometryn is not a possible human carcinogen.

 
 Table 3.  Summary of Dietary (Food + Drinking Water) Exposure and Risk for Prometryn.
                             Population Subgroup[1]
                                Acute Dietary[2]
                               (95th Percentile)
                                Chronic Dietary
                                     Cancer
                                        
                                    Dietary
                              Exposure (mg/kg/day)
                                     % aPAD
                                Dietary Exposure
                                  (mg/kg/day)
                                     % cPAD
                                Dietary Exposure
                                  (mg/kg/day)
                                      Risk
 General U.S. Population
                                       --
                                      --
                                   0.003426
                                      8.6
                                      N/A
                                      N/A
 All Infants (<1 year old)
                                       --
                                      --
                                   0.009081
                                      23
                                        
                                        
 Children 1-2 years old
                                       --
                                       --
                            0.005136                
                                       13
                                        
                                        
 Children 3-5 years old
                                       --
                                       --
                            0.004274                
                                       11
                                        
                                        
 Children 6-12 years old
                                       --
                                       --
                           0.003041                 
                                      7.6
                                        
                                        
 Youth 13-19 years old
                                       --
                                       --
                           0.002484                 
                                      6.2
                                        
                                        
 Adults 20-49 years old
                                       --
                                       --
                           0.003390                 
                                      8.5
                                        
                                        
 Adults 50-99 years old
                                       --
                                       --
                           0.003366                 
                                      8.4
                                        
                                        
 Females 13-49 years old
                                 0.020659      
                                       17
                                    0.003377
                                      8.4
                                        
                                        
 [1]  The values for the highest exposed population for each type of risk assessment is bolded.
 [2]  An acute dietary endpoint (aPAD = 0.12 mg/kg/day) was only determined for females 13-49 years old (see Table 2). 
 
The acute and chronic analyses assumed tolerance-level residues, 100% CT, and DEEM (ver. 7.81) default processing factors.  These analyses are considered very conservative and could be refined using anticipated-residue estimates (ARs), percent market share data, and/or empirical processing factors.  However, at this time refinement is not necessary.

 VIII.  Conclusions
 
The acute and chronic dietary exposure and risk assessments were conducted using DEEM-FCID, Version 3.16, which incorporates consumption data from USDA's NHANES/WWEIA from 2003 through 2008.  

An acute dietary risk analyses was conducted for females 13-49 years old only; an acute endpoint of concern attributable to a single dose was not identified for the general U.S. population.  The acute analysis assumed tolerance-level residues, 100% CT, and DEEM (ver. 7.81) default processing factors.  The acute analysis also incorporated drinking water estimates provided by EFED.  The resulting acute food plus drinking water risk estimates for females 13-49 years old are not of concern to HED (<100% aPAD) at the 95[th] percentile of the exposure distribution for females 13-49 years old.  The resulting acute risk estimate is 17% of the aPAD at the 95[th] percentile of the exposure distribution for females 13-49 years old.

The chronic analysis assumed tolerance-level residues, 100% CT, DEEM (ver. 7.81) default processing factors, as well as drinking water estimates provided by EFED.  The resulting chronic risk estimates are not of concern to HED.  The most highly exposed population was all infants (<1 year old) utilizing 23% of the cPAD.

Attachments
 Attachment 1:  DEEM-FCID Acute Food + Drinking Water Residue Input File.
 Attachment 2:  DEEM-FCID Acute Exposure Estimates for Females 13-49 Years Old.
 Attachment 3:  DEEM-FCID Chronic Food + Drinking Water Residue Input File.
 Attachment 4:  DEEM-FCID Chronic Exposure Estimates.

cc:  S. Levy 
RDI:  G. Kramer (RAB1):  19-APR-2013; DE SAC Reviewers:  19-APR-2013
S. Levy:S10953:PY-S:(703) 305-0783:7509P:RAB1
    Attachment 1:  DEEM-FCID Acute Food + Drinking Water Residue Input File.
                                       
US EPA                                                     Ver. 3.16, 03-08-d
DEEM-FCID Acute analysis for PROMETRYN
Residue file name: C:\Documents and Settings\slevy\Desktop\Prometryn\080805_ACUTE.R08
Analysis Date 04-17-2013             Residue file dated: 04-17-2013/15:28:20
Reference dose: aRfD = 0.12 mg/kg bw/day  NOEL = 12 mg/kg bw/day
Comment: 2E8052 - new uses on snap beans and dill
----------------------------------------------------------------------------------
  EPA      Crop                                   Def Res     Adj.  Factors   Comment
  Code      Grp  Food Name                         (ppm)       #1    #2   
---------- ---- -------------------------------  ----------  ------ ------  -------
0601043000 6A   Bean, snap, succulent              0.050000   1.000  1.0002E8052
0601043001 6A   Bean, snap, succulent-babyfood     0.050000   1.000  1.0002E8052
0402076000 4B   Cardoon                            0.500000   1.000  1.000
0101078000 1AB  Carrot                             0.450000   1.000  1.000
0101078001 1AB  Carrot-babyfood                    0.450000   1.000  1.000
0101079000 1AB  Carrot, juice                      0.450000   1.000  1.000
0101084000 1AB  Celeriac                           0.050000   1.000  1.000
0402085000 4B   Celery                             0.500000   1.000  1.000
0402085001 4B   Celery-babyfood                    0.500000   1.000  1.000
0402086000 4B   Celery, juice                      0.500000   1.000  1.000
0402087000 4B   Celtuce                            0.500000   1.000  1.000
1901118000 19A  Cilantro, leaves                   9.000000   1.000  1.000
1901118001 19A  Cilantro, leaves-babyfood          9.000000   1.000  1.000
2003128000 20C  Cottonseed, oil                    0.250000   1.000  1.000
2003128001 20C  Cottonseed, oil-babyfood           0.250000   1.000  1.000
1902143000 19B  Dill, seed                         1.100000   1.000  1.0002E8052
1901144000 19A  Dillweed                           0.300000   1.000  1.0002E8052
0402152000 4B   Fennel, Florence                   0.500000   1.000  1.000
0802234000 8BC  Okra                               0.050000   1.000  1.000
0401248000 4A   Parsley, leaves                    0.600000   1.000  1.000
1901249000 19A  Parsley, dried leaves              1.500000   1.000  1.000
1901249001 19A  Parsley, dried leaves-babyfood     1.500000   1.000  1.000
0101250000 1AB  Parsley, turnip rooted             0.450000   1.000  1.000
0603258000 6C   Pea, pigeon, seed                  0.250000   1.000  1.000
0602259000 6B   Pea, pigeon, succulent             0.250000   1.000  1.000
0402322000 4B   Rhubarb                            0.500000   1.000  1.000
0402367000 4B   Swiss chard                        0.500000   1.000  1.000
8601000000 86A  Water, direct, all sources         0.377400   1.000  1.000
8602000000 86B  Water, indirect, all sources       0.377400   1.000  1.000
                                        

 Attachment 2:  DEEM-FCID Acute Exposure Estimates for Females 13 to 49 Years Old.
                                        
US EPA                                                      Ver. 3.16, 03-08-d
DEEM-FCID ACUTE Analysis for PROMETRYN                   NHANES 2003-2008 2-Day
Residue file: 080805_ACUTE.R08                        Adjustment factor #2 used.
Analysis Date: 04-17-2013/15:29:05    Residue file dated: 04-17-2013/15:28:20
NOEL (Acute) =  12.000000 mg/kg body-wt/day
RAC/FF intake summed over 24 hours
Run Comment: "2E8052 - new uses on snap beans and dill"
===============================================================================

Summary calculations--per capita:

---   95th Percentile----   ---   99th Percentile----     ---99.9th Percentile----
 Exposure  % aRfD     MOE    Exposure  % aRfD     MOE    Exposure  % aRfD     MOE  
---------- ------- -------- ---------- ------- -------- ---------- ------- --------
Female 13-49:
  0.020659   17.22     580    0.030331   25.28     395    0.042444   35.37     282  

                                        

   Attachment 4:  DEEM-FCID Chronic Food + Drinking Water Residue Input File.

US EPA                                                          Ver. 3.16, 03-08-d
DEEM-FCID Chronic analysis for PROMETRYN
Residue file: C:\Documents and Settings\slevy\Desktop\Prometryn\080805_CHRONIC.R08
                                                               Adjust. #2 used
Analysis Date 04-17-2013             Residue file dated: 04-17-2013/15:24:32
Reference dose (RfD) = 0.04 mg/kg bw/day
----------------------------------------------------------------------------------
 Food      Crop                                   Residue       Adj.    Factors
EPA Code    Grp  Food Name                        (ppm)        #1         #2 
---------- ---- -------------------------------   ---------- ------     ------
0601043000 6A   Bean, snap, succulent              0.050000   1.000      1.000   
0601043001 6A   Bean, snap, succulent-babyfood     0.050000   1.000      1.000   
0402076000 4B   Cardoon                            0.500000   1.000      1.000   
0101078000 1AB  Carrot                             0.450000   1.000      1.000   
0101078001 1AB  Carrot-babyfood                    0.450000   1.000      1.000   
0101079000 1AB  Carrot, juice                      0.450000   1.000      1.000   
0101084000 1AB  Celeriac                           0.050000   1.000      1.000   
0402085000 4B   Celery                             0.500000   1.000      1.000   
0402085001 4B   Celery-babyfood                    0.500000   1.000      1.000   
0402086000 4B   Celery, juice                      0.500000   1.000      1.000   
0402087000 4B   Celtuce                            0.500000   1.000      1.000   
1901118000 19A  Cilantro, leaves                   9.000000   1.000      1.000   
1901118001 19A  Cilantro, leaves-babyfood          9.000000   1.000      1.000   
2003128000 20C  Cottonseed, oil                    0.250000   1.000      1.000   
2003128001 20C  Cottonseed, oil-babyfood           0.250000   1.000      1.000   
1902143000 19B  Dill, seed                         1.100000   1.000      1.000   
1901144000 19A  Dillweed                           0.300000   1.000      1.000   
0402152000 4B   Fennel, Florence                   0.500000   1.000      1.000   
0802234000 8BC  Okra                               0.050000   1.000      1.000   
0401248000 4A   Parsley, leaves                    0.600000   1.000      1.000   
1901249000 19A  Parsley, dried leaves              1.500000   1.000      1.000   
1901249001 19A  Parsley, dried leaves-babyfood     1.500000   1.000      1.000   
0101250000 1AB  Parsley, turnip rooted             0.450000   1.000      1.000   
0603258000 6C   Pea, pigeon, seed                  0.250000   1.000      1.000   
0602259000 6B   Pea, pigeon, succulent             0.250000   1.000      1.000   
0402322000 4B   Rhubarb                            0.500000   1.000      1.000   
0402367000 4B   Swiss chard                        0.500000   1.000      1.000   
8601000000 86A  Water, direct, all sources         0.157900   1.000      1.000   
8602000000 86B  Water, indirect, all sources       0.157900   1.000      1.000   
                                        

              Attachment 5:  DEEM-FCID Chronic Exposure Estimates.
 
 US EPA                                                          Ver. 3.16, 03-08-d
 DEEM-FCID Chronic analysis for PROMETRYN                   NHANES 2003-2008 2-day
 Residue file name: C:\Documents and Settings\slevy\Desktop\Prometryn\080805_CHRONIC.R08
                                                      Adjustment factor #2 used.
 Analysis Date 04-17-2013/15:30:54     Residue file dated: 04-17-2013/15:24:32
 Reference dose (RfD, Chronic) = .04 mg/kg bw/day
 ===============================================================================
                     Total exposure by population subgroup
 -------------------------------------------------------------------------------
 
                                                     Total Exposure
                                          -----------------------------------
           Population                         mg/kg             Percent of   
            Subgroup                       body wt/day             Rfd       
 --------------------------------------   -------------       ----------------
 Total US Population                         0.003426                 8.6%
 Hispanic                                    0.003286                 8.2%
 Non-Hisp-White                              0.003521                 8.8%
 Non-Hisp-Black                              0.002813                 7.0%
 Non-Hisp-Other                              0.003980                10.0%
 Nursing Infants                             0.003425                 8.6%
 Non-Nursing Infants                         0.011607                29.0%
 Female 13+ PREG                             0.003193                 8.0%
 Children 1-6                                0.004520                11.3%
 Children 7-12                               0.002890                 7.2%
 Male 13-19                                  0.002344                 5.9%
 Female 13-19/NP                             0.002621                 6.6%
 Male 20+                                    0.003171                 7.9%
 Female 20+/NP                               0.003576                 8.9%
 Seniors 55+                                 0.003305                 8.3%
 All Infants                                 0.009081                22.7%
 Female 13-50                                0.003382                 8.5%
 Children 1-2                                0.005136                12.8%
 Children 3-5                                0.004274                10.7%
 Children 6-12                               0.003041                 7.6%
 Youth 13-19                                 0.002484                 6.2%
 Adults 20-49                                0.003390                 8.5%
 Adults 50-99                                0.003366                 8.4%
 Female 13-49                                0.003377                 8.4%
 
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