Document ID: EPA-HQ-ORD-2007-1083-0001
Agency: epa
Document Type: Notice
Title: Draft Toxicological Review of 1,2,3-Trichloropropane: In Support of the Summary Information in the Integrated Risk Information System (IRIS)
Posted Date: 2007-11-16T05:00Z

[Federal Register: November 16, 2007 (Volume 72, Number 221)]
[Notices]               
[Page 64626-64627]
From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr16no07-72]                         

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ENVIRONMENTAL PROTECTION AGENCY

 [FRL-8495-5; Docket ID No. EPA-HQ-ORD-2007-1083]

 
Draft Toxicological Review of 1,2,3-Trichloropropane: In Support 
of the Summary Information in the Integrated Risk Information System 
(IRIS)

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice of Public Comment Period.

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SUMMARY: EPA is announcing a public comment period for the external 
review draft document titled, ``Toxicological Review of 1,2,3-
Trichloropropane: In Support of Summary Information on the Integrated 
Risk Information System (IRIS)'' (NCEA-S-1669). The EPA intends to 
consider comments and recommendations from the public and the expert 
panel meeting, which will be scheduled at a later date and announced in 
the Federal Register, when EPA finalizes the draft document. The public 
comment period will provide opportunities for all interested parties to 
comment on the document. EPA intends to forward public comments, 
submitted in accordance with this notice, to the external peer-review 
panel prior to the workshop for their consideration.
    EPA is releasing this draft document solely for the purpose of pre-
dissemination public review under applicable information quality 
guidelines. This document has not been formally disseminated by EPA. It 
does not represent and should not be construed to represent any Agency 
policy or determination.
    The draft document is available via the Internet on NCEA's home 
page under the Recent Additions and the Data and Publications menus at 
http://www.epa.gov/ncea. When finalizing the draft document, EPA intends to 

consider any public comments that EPA receives in accordance with this 
notice.

DATES: The public comment period begins November 16, 2007, and ends 
January 15, 2008. Technical comments should be in writing and must be 
received by EPA by January 15, 2008. EPA intends to submit comments 
from the public received by this date for consideration by the external 
peer-review panel.

ADDRESSES: The draft ``Toxicological Review of 1,2,3-Trichloropropane: 
In Support of Summary Information on the Integrated Risk Information 
System (IRIS)'' is available via the Internet on the National Center 
for Environmental Assessment's (NCEA) home page under the Recent 
Additions and the Data and Publications menus at http://www.epa.gov/ncea. A 

limited number of paper copies are available from the Technical 
Information Staff, NCEA-W; telephone: 202-564-3261; facsimile: 202-565-
0050. If you are requesting a paper copy, please provide your name, 
mailing address, and the document title.
    Comments may be submitted electronically via http://www.regulations.gov, 

by mail, by facsimile, or by hand delivery/courier. Please follow the 
detailed instructions as provided in the SUPPLEMENTARY INFORMATION 
section of this notice.

FOR FURTHER INFORMATION CONTACT: For information on the public comment 
period, contact the Office of Environmental Information Docket; 
telephone: 202-566-1752; facsimile: 202-566-1753; or e-mail: 
ORD.Docket@epa.gov.

    If you have questions about the document, contact Martin Gehlhaus, 
IRIS Staff, National Center for Environmental Assessment, (8601D), U.S. 
EPA, 1200 Pennsylvania Avenue, NW., Washington, DC 20460; telephone: 
202-564-1596; facsimile: 202-565-0075; gehlhaus.martin@epa.gov (e-
mail).

SUPPLEMENTARY INFORMATION: 

I. Summary of Information About the Integrated Risk Information System 
(IRIS)

    IRIS is a database that contains potential adverse human health 
effects information that may result from chronic (or lifetime) exposure 
to specific chemical substances found in the environment. The database 
(available on the Internet at http://www.epa.gov/iris) contains qualitative 

and quantitative health effects information for more than 500 chemical 
substances that may be used to support the first two steps (hazard 
identification and dose-response evaluation) of a risk assessment 
process. When supported by available data, the database provides oral 
reference doses (RfDs) and inhalation reference concentrations (RfCs) 
for chronic health effects, and oral slope factors and inhalation unit 
risks for carcinogenic effects. Combined with specific exposure 
information, government and private entities can use IRIS data to help 
characterize public

[[Page 64627]]

health risks of chemical substances in a site-specific situation and 
thereby support risk management decisions designed to protect public 
health.

II. How To Submit Technical Comments to the Docket at 
http://www.regulations.gov

    Submit your comments, identified by Docket ID No. EPA-HQ-ORD-2007-
1083 by one of the following methods:
     http://www.regulations.gov: Follow the on-line instructions for 

submitting comments.
     E-mail: ORD.Docket@epa.gov.
     Fax: 202-566-1753.
     Mail: Office of Environmental Information (OEI) Docket 
(Mail Code: 2822T), U.S. Environmental Protection Agency, 1200 
Pennsylvania Ave., NW., Washington, DC 20460. The phone number is 202-
566-1752.
     Hand Delivery: The OEI Docket is located in the EPA 
Headquarters Docket Center, EPA West Building, Room 3334, 1301 
Constitution Ave., NW., Washington, DC. The EPA Docket Center Public 
Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through 
Friday, excluding legal holidays. The telephone number for the Public 
Reading Room is 202-566-1744. Such deliveries are only accepted during 
the docket's normal hours of operation, and special arrangements should 
be made for deliveries of boxed information.
    If you provide comments by e-mail or hand delivery, please submit 
one unbound original with pages numbered consecutively, and three 
copies of the comments. For attachments, provide an index, number pages 
consecutively with the comments, and submit an unbound original and 
three copies.
    Instructions: Direct your comments to Docket ID No. EPA-HQ-ORD-
2007-1083. Please ensure that your comments are submitted within the 
specified comment period. Comments received after the closing date will 
be marked ``late,'' and may only be considered if time permits. It is 
EPA's policy to include all comments it receives in the public docket 
without change and to make the comments available online at 
http://www.regulations.gov, including any personal information provided, 

unless a comment includes information claimed to be confidential 
Business Information (CBI) or other information whose disclosure is 
restricted by statute. Do not submit information that you consider to 
be CBI or otherwise protected through http://www.regulations.gov or e-mail. 

The http://www.regulations.gov Web site is an ``anonymous access'' system, 

which means EPA will not know your identity or contact information 
unless you provide it in the body of your comment. If you send an e-
mail comment directly to EPA without going through http://www.regulations.gov, 

your e-mail address will be automatically captured and included as part 
of the comment that is placed in the public docket and made available 
on the Internet. If you submit an electronic comment, EPA recommends 
that you include your name and other contact information in the body of 
your comment and with any disk or CD-ROM you submit. If EPA cannot read 
your comment due to technical difficulties and cannot contact you for 
clarification, EPA may not be able to consider your comment. Electronic 
files should avoid the use of special characters, any form of 
encryption, and be free of any defects or viruses. For additional 
information about EPA's public docket, visit the EPA Docket Center 
homepage at http://www.epa.gov/epahome/dockets.htm.

    Docket: All documents in the docket are listed in the 
http://www.regulations.gov index. Although listed in the index, some 

information is not publicly available, e.g., CBI or other information 
whose disclosure is restricted by statute. Certain other material, such 
as copyrighted material, will be publicly available only in hard copy. 
Publicly available docket materials are available either electronically 
in http://www.regulations.gov or in hard copy at the OEI Docket in the EPA 

Headquarters Docket Center.

    Dated: November 2, 2007.
Rebecca Clark,
Deputy Director, National Center for Environmental Assessment.
 [FR Doc. E7-22444 Filed 11-15-07; 8:45 am]

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