Document ID: EPA-HQ-OPP-2006-0576-0011
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2007-04-11T04:00Z

SEQ CHAPTER \h \r 1 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF              

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES 

MEMORANDUM

Date:		23-January-2007

Subject:	Tetraconazole.  Dietary Exposure and Risk Assessment. 
Application of Tetraconazole to Pecan, Sugar Beet, and Soybean.  PC
Code:  120603.  DP No.:  321637.  Decision No.:  359652.  Registration
No.:  5F6971.

From:		Tom Bloem, Chemist

			Registration Action Branch 1/Health Effects Division (RAB1/HED;
7509P)

Through:	Susan Stanton, Environmental Scientist, Reregistration Action
Branch 3/HED

			Mohsen Sahafeyan, Chemist, RAB1/HED

			Dietary Exposure Science Advisory Committee (DESAC) Secondary Review

			George Kramer, Ph.D., Senior Chemist

			RAB1/HED (7509P)

To:			Mary Clock-Rust, Chemist

			RAB1/HED (7509P)

Executive Summary

The residues of concern following application of tetraconazole includes
compounds which HED has determined to be toxicologically different from
tetraconazole.  The current memorandum pertains only to exposure to
tetraconazole and those compounds which HED has determined are
toxicologically equivalent to tetraconazole (information concerning
exposure to the remaining compounds can be found in the HED risk
assessment; D331476, M. Clock-Rust et al., in draft).  

ood Consumption Intake Database (DEEM-FCID™, ver. 2.03) which
incorporates the food consumption data from the USDA’s Continuing
Surveys of Food Intakes by Individuals (CSFII; 1994-1996 and 1998). 
These analyses were conducted in support of the proposed application of
tetraconazole to soybean (Section 3 Registration), sugar beet
(nationwide Section 3 Registration), peanut (Section 3 Registration),
and turf (Section 3 Registration).  The following paragraphs are
summaries of the acute, chronic, and cancer analyses.  

Acute:  The tier 1 acute analysis (food and water; water estimate
derived from the proposed turf application scenario) resulted in
exposure estimate for females 13-49 years old less than HED’s level of
concern (3% aPAD; acute endpoint of concern was not identified for the
general population including infants and children).  Since the turf
water estimates resulted in an unacceptable cancer risk by themselves
(see below) and registration for application of tetraconazole will most
likely not be established, the acute analysis was repeated with
exclusion of the turf use (water estimate derived from the pecan
application scenario is used).  The resulting exposure estimate for
females 13-49 years old is less than HED’s level of concern (<1%
aPAD).  

were less than HED’s level of concern (≤10% cPAD; all infants <1
year old were the most highly exposed population subgroup).

Cancer:  Using only the water estimates from application to turf,
including the turf estimate generated if the use is restricted to golf
courses, the cancer risk for the U.S. population was ≥4.3 x 10-6 (food
residues were not included).  Therefore, the water estimates resulting
from application to turf were excluded for the analyses discussed below.
 

A cancer analysis was performed using empirical processing factors,
average field trial residues, average residues from the feeding studies,
projected percent crop treated estimates, and the water estimate derived
from the pecan application scenario (4.97 ppb; 8 x 0.125 lb ai/acre;
highest estimate when turf is excluded).  The resulting exposures
estimates yielded a cancer risk for the U.S. population of 3.1 x 10-6. 
A complete commodity analysis indicates that drinking water contributes
78% of the total exposure, soybean oil contributes 18of the total
exposure, and the remaining food commodities contribute 4% of the total
exposure.  Excluding the turf and pecan water estimates, the next
highest water estimate results from the sugar beet application scenario
(3.77 ppb; 2 x 0.10 lb ai/acre).  Using the same food residue estimates
as that from the previous analysis except for the elimination of pecans,
the cancer risk for the U.S. population is 2.5 x 10-6.

I.  Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population-adjusted dose
(PAD).  The PAD is equivalent to the point of departure divided by the
required safety factors.  For acute and non-cancer chronic exposures,
HED is concerned when estimated dietary risk exceeds 100% of the PAD. 
HED is generally concerned when estimated cancer risk exceeds one in one
million.  References which discuss the acute and chronic risk
assessments in more detail are available on the EPA/pesticides web site:
 “Available Information on Assessing Exposure from Pesticides, A
User’s Guide,” 6/21/2000, web link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see
SOP 99.6 (8/20/99).  The most recent dietary risk assessment for
tetraconazole was conducted by L. Jones (D314309, 8-Mar-2005; risk
assessment document).

II.  Residue Information

Residues of Concern in Plants and Livestock:  Table 1 is a summary of
the residues of concern in plants and livestock (for a complete
discussion concerning these conclusions, refer to D331476, M. Clock-Rust
et al., in draft).  HED has concluded that the toxicological effects
resulting from exposure to 1,2,4-triazole (T), triazolyl alanine (TA),
triazolyl acetic acid (TAA), triazolyl hydroxypropionic acid (THP), and
all labile conjugates of these compounds and M14360(C-1)-alcohol are
different from that resulting from exposure to tetraconazole; HED
concluded that the toxicity of the remaining metabolites are identical
to that of tetraconazole.  The current dietary exposure analysis
pertains only to exposure to those compounds which HED has concluded are
toxicologically similar to tetraconazole (i.e. tetraconazole,
M14360-alcohol (free and conjugated), M14360-acid, M14360-DFA, and
M14360-hydroxydetriazolyl-O-malonyldiglucoside); Information concerning
exposure to the remaining compounds can be found in the HED risk
assessment; D331476, M. Clock-Rust et al., in draft).

Table 1.  Residues for Tolerance Expression and Risk Assessment

Matrix	Residues included in Risk Assessment	Residues included in
Tolerance Expression

Shelled Pea 

and Bean	tetraconazole and 1,2,4-triazole (T), triazolyl alanine (TA),
triazolyl acetic acid (TAA), and all labile conjugates of these
compounds	tetraconazole

Remaining Plants	tetraconazole, M14360-alcohol (free and conjugated),
M14360-acid, M14360-DFA, M14360-hydroxydetriazolyl-O-malonyldiglucoside,
and T, TA, TAA and all labile conjugates of these compounds
tetraconazole

Livestock	tetraconazole, M14360-alcohol (free and conjugated),
M14360-acid, M14360-DFA, M14360(C-1)-alcohol (free and conjugated),
M14360-hydroxydetriazolyl-O-malonyldiglucoside, and T, TA, THP, and TAA
and all labile conjugates of these compounds	tetraconazole

Rotational Crops	tetraconazole, M14360-acid, M14360-DFA,
M14360(C-1)-alcohol (free and conjugated), and TA, THP, and TAA and all
labile conjugates of these compounds	tetraconazole

Drinking Water	tetraconazole	not applicable

Currently Established Tolerances and HED Recommended Tolerances:  
Tolerances for residues of tetraconazole per se have been established
in/on sugar beet (regional registration) and livestock commodities (40
CFR 180.557).  A Section 18 soybean (forage and hay may not be fed to
livestock) registration has also been granted which resulted in the
setting of temporary soybean and poultry tolerances.  The petitioner is
currently requesting a national sugar beet registration and Section 3
registrations for turf, soybean, pecan, and peanut.  HED has reviewed
the residue chemistry data submitted in support of these requests and
concludes that the tolerances listed in the Table 2, for residues of
tetraconazole per se, are appropriate (D331594, T. Bloem, 23-Jan-2007;
D329379, T. Bloem, 23-Jan-2007; D327489, T. Bloem, 23-Jan-2007).  

HED notes that the proposed peanut application scenario prohibits the
feeding of peanut hay to livestock and the registered soybean Section 18
and the proposed soybean Section 3 registration prohibit the feeding of
soybean forage and hay to livestock.  In addition, sugar beet tops are
being eliminated as a feed commodity from OPPTS 860.1000 (communication
from J. Stokes, HED).  Based on the restrictions of the labels and with
the elimination of sugar beet tops as a feed commodity, the ruminant
dietary burden has been greatly reduced and HED has recommended for the
elimination of the currently established milk and cattle, goat, horse,
and sheep tolerances in favor of the tolerances listed in Table 2
(D329379, T. Bloem, 23-Jan-2007).  

In addition, HED notes that the currently established soybean and
poultry tolerances were recommended as part of the soybean Section 18
registration.  Since the soybean application scenario approved as part
of the Section 18 registration and the soybean application scenario
being proposed as part of the Section 3 registration are identical and
since HED has performed a complete review of the soybean and poultry
magnitude of the residue data as part of the current review, HED
concludes that the recommended soybean and poultry tolerances are
appropriate (i.e., the poultry and soybean tolerances from Table 2 were
used for the current assessment).  

Table 2:  HED-Recommended Tolerances

Commodity	HED Recommended Tolerance (ppm)

beet sugar, root	0.05

beet, sugar, dried pulp	0.15

beet, sugar, molasses	0.15

peanut	0.03

peanut, oil	0.10

pecan	0.04

soybean, seed	0.15

soybean, refined oil	0.80

aspirated grain fractions	1.0

poultry, meat	0.01

poultry, fat	0.05

poultry meat byproducts	0.01

eggs	0.02

cattle, meat	0.01

cattle, liver	0.20

cattle, fat	0.02

cattle, meat byproducts (except liver)	0.01

milk	0.01

milk, fat	0.25

goat, meat	0.01

goat, liver	0.20

goat, fat	0.02

goat, meat byproducts (except liver)	0.01

hog, meat	0.01

hog, liver	0.05

hog, fat	0.01

hog, meat byproducts (except liver)	0.01

horse, meat	0.01

horse, liver	0.20

horse, fat	0.02

horse, meat byproducts (except liver)	0.01

sheep, meat	0.01

sheep, liver	0.20

sheep, fat	0.02

sheep, meat byproducts (except liver)	0.01

Residue Estimates for the Acute and Chronic Analyses:  As stated earlier
in the document, HED concluded that the toxicity of T, TA, TAA, THP, and
all labile conjugates of these compounds and M14360(C-1)-alcohol are
different from that resulting from exposure to tetraconazole.  Since the
current document is concerned with exposure to compounds which HED has
determined are toxicologically similar to tetraconazole, these compounds
were not considered.  

The petitioner submitted field trial and processing data for
tetraconazole per se.  These data are sufficient for soybean
tetraconazole risk assessment; however, the residues of concern for a
tetraconazole risk assessment in sugar beet, pecan, and peanut includes
tetraconazole, M14360-alcohol (free and conjugated), M14360-acid,
M14360-DFA, and M14360-hydroxydetriazolyl-O-malonyldiglucoside.  The
magnitude of these residues were estimated based on the tetraconazole
metabolites to tetraconazole residues ratios from the metabolism studies
(sugar beet leaves:  0.06 (0-day preharvest interval (PHI) and 0.32-0.33
(23-35 day PHI); root:  0.26 (23-day PHI); wheat straw:  0.02; wheat
grain - metabolites were not identified; grape metabolism studies only
included parent as a reference standard with none of the metabolites
identified).  HED concludes that the sugar beet root residue ratio is
appropriate for the currently proposed crops (sugar beet, peanut, and
pecan; these compounds were not identified as residues of concern in
soybean seed).  Table 4 is a summary of the tetraconazole per se
residues, estimated residues of the metabolites of concern for a
tetraconazole risk assessment, and total residues.  

The livestock tolerances are based on residues of tetraconazole per se
derived from the consumption of fed commodities which contain
tetraconazole per se; however, as stated above, the residues of concern
for a tetraconazole risk assessment in both feed (excluding soybean feed
commodities) and livestock are tetraconazole, M14360-alcohol (free and
conjugated), M14360-acid, M14360-DFA, and
M14360-hydroxydetriazolyl-O-malonyldiglucoside.  Therefore, the acute
and chronic dietary assessment included livestock residues which were
calculated based on dietary burdens which included all of the residues
of concern for a tetraconazole risk assessment.  This dietary burden was
then used to calculate residues in the livestock tissues based on the
tetraconazole per se transfer coefficients (i.e., assessments assumes
that transfer coefficient for the tetraconazole metabolites are
identical to tetraconazole). Table 3 is a summary of the dietary burden
calculations and Table 5 is a summary of the residue estimates in the
livestock commodities.  HED notes that if the acute residue estimates
for the livestock commodities in Table 5 were <LOQ, LOQ residues were
assumed.  

Table 3:  Livestock Dietary Burden Calculations for Refinement of the
Chronic Dietary Analysis

commodity1	% diet1	% dry matter	residue (ppm)	dietary burden2

	acute	chronic	acute	chronic

beef cattle

sugar beet dried pulp (R; 70%)	20	88	0.189	0.053	0.043	0.008

sugar beet molasses (CC; 70% )	10	75	0.189	0.071	0.025	0.007

peanut meal (PC; 77%)3	15	85	0.063	0.016	--	0.002

soybean seed (PC; 27%)3	15	89	0.15	0.046	0.025	--

soybean hull (R; 27%)	20	90	0.15	0.046	0.033	0.003

soybean aspirated grain fractions (CC; 27%)	5	85	1.0	0.345	0.059	0.005

total	70	--	--	--	0.186	0.025

dairy cattle

sugar beet dried pulp (R; 70%)	20	88	0.189	0.053	0.043	0.008

sugar beet molasses (CC; 70%)	10	75	0.189	0.071	0.025	0.007

peanut meal (PC; 77%)3	15	85	0.063	0.016	--	0.002

soybean seed (PC; 27%)3	15	89	0.15	0.046	0.025	--

soybean hull (R; 27%)	20	90	0.15	0.046	0.033	0.003

total	80	--	--	--	0.127	0.020

poultry

soybean meal (PC; 27%)	35	--	0.15	0.046	0.052	0.004

soybean hull (R; 27%)	10	--	0.15	0.046	0.015	0.001

total	45	--	--	--	0.068	0.006

hog

soybean seed (PC; 27%)	25	--	0.15	0.046	0.038	0.003

total	25	--	--	--	0.038	0.003

1	from revised Table 1; R = roughage, CC = carbohydrate concentrate, PC
= protein concentrate; peanut hay and soybean forage and hay are not to
be fed to livestock (therefore not included); percentage refers percent
crop treated (see attachment 1) which were used in the chronic dietary
burden calculations

2	beef/dairy cattle dietary burden = residue x % diet ÷ % dry matter;
poultry/hog dietary burden = residue x % diet; chronic calculations
included the percent crop treated estimates

3	peanut meal was included in the chronic dietary burden calculations
instead of soybean seed due to the differences in the % crop treated for
peanut and soybean (inclusion of peanut meal results in a higher dietary
burden)



Table 4:  Food/Feed Residue Estimates for Acute, Chronic, and Cancer
Analyses

matrix	tetraconazole residue (ppm)	factor1	total residue2	comments

	acute	chronic/

cancer

acute	chronic/

cancer

	soybean (seed, hulls, and meal)	0.15	0.046	--3	0.15	0.046	acute
tetraconazole residue = tolerance residue

chronic tetraconazole residues = average field trial residue
(46614332.der.doc) multiplied by 2x to account for insufficient
analytical method (see text above)

soybean oil	0.80	0.212	--3	0.80	0.212	acute tetraconazole residue =
tolerance residue

chronic tetraconazole residues = average soybean seed field trial
residue multiplied by the average processing factor 4.6x
(46614320.der.doc) multiplied by 2x to account for insufficient
analytical method (see text above)

soybean aspirated grain fractions	1.0	0.345	--3	1.0	0.345	acute
tetraconazole residue = tolerance residue

chronic tetraconazole residues = average soybean seed field trial
residue multiplied by the average processing factor 7.5x
(46614320.der.doc) multiplied by 2x to account for insufficient
analytical method (see text above)

sugar beet root sugar	0.05	0.002	0.26	0.063	0.0025	acute tetraconazole
residue = tolerance residue

chronic tetraconazole residues = average field trial residue multiplied
by 0.50 based on reduction in the application rate and side-by-side
field trial data multiplied by 0.1x processing factor (D279986, W.
Donovan, 17-May-2002; ChemSAC minutes 15-May-2002; D310763, T. Bloem,
24-Nov-2004)

sugar beet molasses	0.15	0.056	0.26	0.189	0.071	acute tetraconazole
residues = tolerance residue

chronic tetraconazole residues = average field trial residue multiplied
by 0.50 based on reduction in the application rate and side-by-side
field trial data and multiplied by 2.8x processing factor (D279986, W.
Donovan, 17-May-2002; ChemSAC minutes 15-May-2002; D310763, T. Bloem,
24-Nov-2004)

sugar beet dried pulp	0.15	0.042	0.26	0.189	0.053	acute tetraconazole
residues = tolerance residue

chronic tetraconazole residues = average field trial residue multiplied
by 0.50 based on reduction in the application rate and side-by-side
field trial data and multiplied by 2.1x processing factor (D279986, W.
Donovan, 17-May-2002; ChemSAC minutes 15-May-2002; D310763, T. Bloem,
24-Nov-2004)

peanut (mutmeat and meal)	0.03	0.013	0.26	0.038	0.016	acute
tetraconazole residue = tolerance residue

chronic tetraconazole residues = average field trial residue (D259231,
W. Donovan, 18-May-2000)

peanut oil	0.10	0.043	0.26	0.126	0.055	acute tetraconazole residues =
tolerance residue

chronic tetraconazole residues = average peanut field trial residue
multiplied by 3.34x processing factor (D259231, W. Donovan, 18-May-2000)

pecan	0.04	0.007	0.26	0.050	0.009	acute tetraconazole residue =
tolerance residue

chronic tetraconazole residues = average field trial residue
(46037601.der.doc)

1	factor = residue ratio of non-free triazole tetraconazole metabolites
of concern to tetraconazole from the metabolism studies; sugar beet root
factor (0.26x) used for all commodities

2	total residue = residue + (residue)(factor)

3	the non-free triazole tetraconazole metabolites are not residues of
concern in soybean seed

Table 5:  Livestock Residues for Acute and Chronic Analysis

matrix	tetraconazole residue from feeding study1 (ppm)	tetraconazole
transfer coeffcients2	residue estimates3

	lowest dietary burden	middle dietary burden  	highest dietary burden 
lowest dietary burden	middle dietary burden	highest dietary burden	acute
chronic

dairy cattle

milk4	<0.003	max = 0.016;

avg = 0.006	max = 0.048

avg = 0.019	--	based on max res - 0.016

based on avg res - 0.006	based on max res - 0.014

based on avg res - 0.006	0.00199	0.000113

milk fat	milk fat was not analyzed in the feeding studies; since
residues in fat were significantly higher than those in muscle from the
feeding studies, HED concluded that a 25x concentration factor for milk
fat was appropriate (milk fat residue = milk residue x 25)	0.050
0.002825

skimmed milk	<0.003	<0.003	max = 0.003

avg = 0.003	--	--	based on max res - 0.0009

based on avg res - 0.0009	0.000114	0.000018

cream	max = 0.023

avg = 0.020	max = 0.125

avg = 0.073	max = 0.391

avg = 0.283	based on max res - 0.068

based on avg res - 0.060	based on max res - 0.122

based on avg res - 0.072	based on max res - 0.115

based on avg res - 0.083	0.0156	0.00167

beef cattle/hog

subcutaneous fat	max = 0.003

avg = 0.003	max = 0.033

avg = 0.029	max = 0.205

avg = 0.109	--	based on max res - 0.032

based on avg res - 0.029	based on max res - 0.060

based on avg res - 0.032	beef = 0.0112

hog = 0.00229	beef = 0.000801

hog = 0.000096

peritoneal fat	max = 0.029

avg = 0.016	max = 0.069

avg = 0.051	max = 0.199

avg = 0.114	based on max res - 0.085

based on avg res - 0.046	based on max res - 0.068

based on avg res - 0.050	based on max res - 0.059

based on avg res - 0.033	beef = 0.0159

hog = 0.00324	beef = 0.00124

hog = 0.000149

kidney	max = 0.007

avg = 0.005	max = 0.039

avg = 0.024	max = 0.067

avg = 0.055	based on max res - 0.021

based on avg res - 0.016	based on max res - 0.038

based on avg res - 0.024	based on max res - 0.020

based on avg res - 0.016	beef = 0.00711

hog = 0.00145	beef = 0.000596

hog = 0.000072

liver	max = 0.371

avg = 0.268	max = 0.662

avg = 0.376	max = 1.636

avg = 1.345	based on max res - 1.091

based on avg res - 0.789	based on max res - 0.649

based on avg res - 0.368	based on max res - 0.481

based on avg res - 0.395	beef = 0.203

hog = 0.0415	beef = 0.01973

hog = 0.00237

muscle	<0.003	max = 0.006

avg = 0.005	max = 0.015

avg = 0.011	--	based on max res - 0.006

based on avg res - 0.005	based on max res - 0.004

based on avg res - 0.003	beef = 0.00109

hog = 0.000224	beef = 0.000114

hog = 0.000014

poultry

liver	max = 0.011

avg = 0.010	max = 0.029

avg = 0.026	max = 0.081

avg = 0.073	based on max res - 0.159

based on avg res - 0.145	based on max res - 0.120

based on avg res - 0.108	based on max res - 0.113

based on avg res - 0.102	0.0108	0.00087

kidney	<0.01	<0.01	max = 0.049

avg = 0.040	--	--	based on max res - 0.069

based on avg res - 0.056	0.00467	0.000336

skeletal muscle	<0.01	<0.01	max = 0.021

avg = 0.021	--	--	based on max res - 0.029

based on avg res - 0.029	0.00200	0.000176

abdominal fat	max = 0.045

avg = 0.038	max = 0.140

avg = 0.115	max = 0.456

avg = 0.387	based on max res - 0.652

based on avg res - 0.551	based on max res - 0.581

based on avg res - 0.477	based on max res - 0.639

based on avg res - 0.542	0.0443	0.003304

skin and subcutaneous fat	max = 0.019

avg = 0.015	max = 0.044

avg = 0.041	max = 0.181

avg = 0.164	based on max res - 0.275

based on avg res - 0.217	based on max res - 0.183

based on avg res - 0.170	based on max res - 0.253

based on avg res - 0.230	0.0187	0.001378

eggs5	max = 0.011

avg = 0.008	max = 0.034

avg = 0.025	max = 0.135

avg = 0.089	based on max res - 0.159

based on avg res - 0.116	based on max res - 0.141

based on avg res - 0.104	based on max res - 0.189

based on avg res - 0.125	0.0129	0.000748

1	ruminant feeding study - D254411, W. Donovan, 18 May-2000 (dietary
burdens of 0.34 ppm, 1.02 ppm, and 3.4 ppm); poultry feeding study
-46614307.der.wpd (dietary burdens of 0.069 ppm, 0.241 ppm, and 0.714
ppm)

2	transfer coefficient = tetraconazole residue ÷ dietary burden; for
the acute analysis the residues in bold were <tolerance therefore
defaulted to the tolerance

3	residue estimate = dietary burden x transfer coefficient; the highest
transfer coefficient derived from a dosing level which resulted in
quantifiable residues was used

4	residues in milk peaked on the third day of dosing; therefore, the
average residue is for all samples collected on day 3 and after

5	residues in egg peaked on the tenth day of dosing; therefore, the
average residue is for all samples collected on day 10 and after

III.  Drinking Water Data

EFED provided modeled ground (Screening Concentration In Ground Water
(SCIGROW)) and surface (Pesticide Root Zone Model (PRZM 3.12) and
Exposure Analysis Modeling System (EXAMS 2.98.04)) water concentrations
for tetraconazole per se (EFED memorandum prepared by I. Maher,
December-2006).  Table 6 is a summary of the estimates provided by EFED.
 The water estimates were incorporated directly into the dietary
exposure analysis via the water sources direct (all sources) and
indirect (all sources) commodities.  The water models and their
description are available at the EPA internet site:   HYPERLINK
"http://www.epa.gov/ oppefed1/models/water/"  http://www.epa.gov/
oppefed1/models/water/ .  

Table 6:  Summary of Ground and Surface Water Modeled Water Estimates

crop	state and application method modeled	ppb ((g/l)

peak	yearly	30-year annual average

ground water

sugar beet	0.36

turf	10.0

peanut	0.72

soybean	0.27

pecan	1.79

surface water

sugar beet	Minnesota; aerial spray1	7.22	4.97	3.77

	Minnesota; ground spray1	6.33	4.40	3.20

	California; aerial spray1	2.12	1.43	1.30

	California; ground spray1	0.86	0.59	0.52

peanut	North Carolina; aerial spray2	10.36	4.03	3.02

	North Carolina; ground spray2	10.02	3.83	2.78

soybean	Mississippi; aerial spray3	1.29	0.59	0.47

	Mississippi; ground spray3	1.18	0.56	0.42

pecan	Georgia; aerial spray4	20.01	7.26	4.97

	Georgia; ground spray4	19.46	6.79	4.41

turf	Pennsylvania; aerial spray	118.00	77.13	59.90

	Pennsylvania; ground spray	87.40	57.55	41.03

	Florida; aerial spray	77.52	44.74	36.94

	Florida; ground spray	57.70	33.77	25.97

golf course turf	Pennsylvania; aerial spray5	40.12	26.22	20.37

	Pennsylvania; ground spray5	29.72	19.57	13.95

	Florida; aerial spray5	26.36	15.21	12.56

	Florida; ground spray5	19.62	11.48	8.83

1	  SEQ CHAPTER \h \r 1 EXAMS EEC multiplied by 0.87 to account for
percent of basin cropped (assumes 100% of the crop treated)

2	EXAMS EEC multiplied by 0.67 to account for percent of basin cropped
(assumes 100% of the crop treated)

3	EXAMS EEC multiplied by 0.41 to account for percent of basin cropped
(assumes 100% of the crop treated)

4	EXAMS EEC multiplied by 0.85 to account for percent of basin cropped
(assumes 100% of the crop treated)

5	EXAMS EEC multiplied by 0.34 to account for percent of basin cropped
(assumes 100% of the crop treated)

DEEM-FCID™ Program and Consumption Information

Acute and chronic dietary exposure assessments were conducted using
DEEM-FCID™ (ver. 2.03) which incorporates consumption data from
USDA’s CSFII, 1994-1996 and 1998.  The 1994-96, 98 data are based on
the reported consumption of more than 20,000 individuals over two
non-consecutive survey days.  Foods “as consumed” (e.g., apple pie)
are linked to EPA-defined food commodities (e.g. apples, peeled fruit -
cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S,
baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA.  For chronic exposure assessment,
consumption data are averaged for the entire U.S. population and within
population subgroups, but for acute exposure assessment are retained as
individual consumption events.  Based on analysis of the 1994-96, 98
CSFII consumption data, which took into account dietary patterns and
survey respondents, HED concluded that it is most appropriate to report
risk for the following population subgroups: the general U.S.
population, all infants (<1 year old), children 1-2, children 3-5,
children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+
years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., only those who reported
eating relevant commodities/food forms) and a per-capita (i.e., those
who reported eating the relevant commodities as well as those who did
not) basis.  In accordance with HED policy, per capita exposure and risk
are reported for all tiers of analysis.  However, for tiers 1 and 2, any
significant differences in user vs. per capita exposure and risk are
specifically identified and noted in the risk assessment.

V.  Toxicological Information

The HED Hazard Identification Assessment Review Committee (HIARC) met on
14-September-1999 (HED Doc. No. 013765) and 13-May-2004 (TXR No.
0052657) to select endpoints for risk assessment and to evaluate the
potential for increased susceptibility of infants and children from
exposure to tetraconazole (evaluated according to the February 2002 OPP
10X guidance document).  The HED Cancer Assessment Review Committee met
on 10-November-1999 and classified tetraconazole as a likely human
carcinogen (HED Doc. No. 013948).

The HIARC, based on toxicological considerations recommended for a 1x
FQPA.  Based on toxicological considerations (evaluated by HIARC) and
the residue assumptions used in the dietary analyses (evaluated by the
reviewer), it was concluded that the FQPA Safety Factor should be
reduced to 1x when assessing dietary exposures.  Table 7 summarizes the
endpoints used for dietary exposure assessment.   

Table 7:  Summary of Toxicological Doses and Endpoints for Tetraconazle
Dietary Exposure Assessment1

Exposure Scenario	Dose Used in Risk

Assessment, UF	FQPA SF* and Dose for Risk Assessment	Study and
Toxicological Effects

Acute Dietary - general population (including infants and children)	None
N/A	No endpoint attributable to a single exposure was identified.  This
risk assessment is not required.

Acute Dietary - Females 13-50 years of age	NOAEL = 22.5 mg/kg/day

UF = 100

aRfD = 0.225 mg/kg/day	FQPA SF = 1X

aPAD = aRfD ÷ FQPA SF

= 0.225 mg/kg	Oral developmental toxicity study - rat

Developmental NOAEL = 22.5 mg/kg/day, based on increased incidence of
small fetuses, and supernumerary ribs. 

Chronic Dietary -

all populations	NOAEL= 0.73 mg/kg/day

UF =100

cRfD = 0.0073 mg/kg/day	FQPA SF = 1 

cPAD = cRfD ÷ FQPA SF

cPAD = 0.0073 mg/kg/day 	Chronic oral toxicity - dog 

Systemic Toxicity LOAEL = 2.95/3.33 (M/F) mg/kg/day, based on absolute
and relative kidney weights and histopathological changes in the male
kidney.

Cancer	Classification: “likely to be carcinogenic to humans” Q1*= 
2.30 x 10-2, based on male mouse liver benign and/or malignant combined
tumor rates.

1	NOAEL = No Observed Adverse Effect Level; LOAEL = Lowest Observed
Adverse Effect Level; UF = Uncertainty Factor; RfD = Reference Dose; PAD
= Chronic Population Adusted Dose = RfD ÷ FQPA SF

VI.  Results/Discussion & Conclusions

Acute:  The tier 1 acute analysis (food and water (turf application
scenario; 4 x 1.4 lb ai/acre)) resulted in exposure estimate for females
13-49 years old of 3% aPAD (see Table 8; acute endpoint of concern was
not identified for the general population including infants and
children).  If the turf use is excluded (water estimate derived from the
pecan application scenario is used; 8 x 0.125 lb ai/acre), the resulting
exposure estimate for females 13-49 years old is <1% aPAD (see Table 9).
 

Chronic:  The tier 2 chronic analysis (food and water (turf application
scenario; 4 x 1.4 lb ai/acre)) incorporated average field trial residues
and average residues from the feeding studies (100% crop treated
assumed).  The resulting chronic exposures estimates were ≤76% cPAD
(all infants <1 year old were the most highly exposed population
subgroup; Table 8).  If the turf use is excluded (water estimate derived
from the pecan application scenario is used; 8 x 0.125 lb ai/acre), the
resulting exposure estimates are ≤10% cPAD (all infants <1 year old
were the most highly exposed population subgroup; Table 9)

Cancer:  Using only the drinking water concentrations resulting from
application to turf (food residue excluded), the cancer risk for the
U.S. population was ≥4.3 x 10-6 (Table 10).  Therefore, the water
estimates resulting from application to turf were excluded for analyses
discussed below.  

The tier 2 chronic analysis (food and water) incorporated empirical
processing factors, average field trial residues, average residues form
the feeding studies, projected percent crop treated estimates, and the
water estimate derived from the pecan application scenario (4.97 ppb; 8
x 0.125 lb ai/acre; highest estimate when turf is excluded).  The
resulting exposures estimates yielded a cancer risk for the U.S.
population of 3.1 x 10-6 (Table 11).  A complete commodity analysis
indicates that drinking water contributes 78% of the total exposure,
soybean oil contributes 18% of the total exposure, and the remaining
food commodities contribute 4% of the total exposure (see attachment
12).  

Excluding the turf and pecan water estimates, the next highest water
estimate results from the sugar beet application scenario (3.77 ppb; 2 x
0.10 lb ai/acre).  Using the same food residue estimates as that from
the previous analysis except for the elimination of pecans, the cancer
risk for the U.S. population is 2.5 x 10-6 (Table 10).  



Table 8:  Summary of the Acute and Chronic Dietary Exposure and Risk
(all commodities; drinking water included)

Population	aPAD (mg/kg/day)	Exposure (mg/kg/day)1	%aPAD	cPAD (mg/kg/day)
Exposure (mg/kg/day)	%cPAD

General U.S. Population	no acute endpoint identified for these
population subgroups	0.073	0.001724	24

All Infants (< 1 year old)

	0.005564	76

Children 1-2 years old

	0.002629	36

Children 3-5 years old

	0.002480	34

Children 6-12 years old

	0.001717	24

Youth 13-19 years old

	0.001276	18

Adults 20-49 years old

	0.001597	22

Adults 50+ years old

	0.001660	23

Females 13-49 years old	0.225	0.006168	2.7

0.001587	22

1	95th percentile (tier 1 analysis)

Table 9:  Summary of the Acute and Chronic Dietary Exposure and Risk
(all commodities excluding turf; drinking water included)

Population	aPAD (mg/kg/day)	Exposure (mg/kg/day)1	%aPAD	cPAD (mg/kg/day)
Exposure (mg/kg/day)	%cPAD

General U.S. Population	no acute endpoint identified for these
population subgroups	0.073	0.000252	3.4

All Infants (< 1 year old)

	0.000735	10.1

Children 1-2 years old

	0.000442	6.0

Children 3-5 years old

	0.000432	5.9

Children 6-12 years old

	0.000305	4.2

Youth 13-19 years old

	0.000212	2.9

Adults 20-49 years old

	0.000222	3.0

Adults 50+ years old

	0.000213	2.9

Females 13-49 years old	0.225	0.001603	<1

0.000218	3.0

1	95th percentile (tier 1 analysis)

Table 10:  Summary of the Cancer Dietary Exposure and Risk Resulting
from Application of Tetraconazole to Turf (only water concentrations
resulting from the turf application included; no food)

Included Commodities	Exposure (mg/kg/day)1	Q1*	Cancer risk

59.90 (PA aerial spray turf)	0.001263	0.023	2.9 x 10-5

41.03 (PA ground spray turf)	0.000865

2.0 x 10-5

36.94 (FL aerial spray turf)	0.000779

1.8 x 10-5

25.97 (FL ground spray turf)	0.000547

1.3 x 10-5

20.37 (PA aerial spray golf course turf)	0.000429

9.9 x 10-6

13.95 (PA ground spray gold course turf)	0.000294

6.8 x 10-6

12.56 (FL aerial spray golf course turf)	0.000265

6.1 x 10-6

8.83 (FL ground spray golf course turf)	0.000186

4.3 x 10-6

1	exposure for the general U.S. population; HED performs cancer analyses
for only the general U.S. population

Table 11:  Summary of the Cancer Dietary Exposure and Risk Resulting
from all Registered/Proposed Uses Excluding Turf

Scenario	Population1	Exposure (mg/kg/day)	Q1*	Cancer risk

all crops 

excluding turf	general U.S. population	0.000134	0.023	3.09x 10-6

all crops excluding turf and pecan	general U.S. population	0.000109

2.50x 10-6

1	exposure for the general U.S. population; HED performs cancer analyses
for only the general U.S. population

VII.  Characterization of Inputs/Outputs

The acute analysis could be refined through the incorporation of maximum
or highest average field trial residues, percent crop treated estimates,
and/or monitoring data.  The chronic/cancer analyses incorporated
average field trial residues, average residues from the feeding studies,
and/or projected percent crop treated information and could be refined
through the incorporation of monitoring data.  A complete commodity
analysis conducted for the general U.S. population cancer assessment
(all proposed/registered uses excluding turf) indicates that water (78%
of the total exposure) and soybean oil (18% of the total exposure) are
the major contributors.

VIII.  Conclusions

 (≤76% of the cPAD) exposure estimates are less than HED’s level of
concern.  Cancer analyses were performed using only the turf water
estimates and resulted in cancer risks greater than HED’s level of
concern (≥4.3 x 10-6).  With exclusion of the turf water estimates and
inclusion of all the remaining proposed/registered uses, the cancer risk
was 3.1 x 10-6.  With the exclusion of the turf and pecan uses, the
cancer risk was 2.5 x 10-6.  

Attachment 1:  BEAD percent crop treated information

  DEEM-FCID™ acute exposure estimates (all commodities)

Attachment 3:  DEEM-FCID™ acute exposure estimates (all commodities
excluding turf)

Attachment 4:  DEEM-FCID™ acute residue file

Attachment 5:  DEEM-FCID™ chronic exposure estimates (all commodities)

Attachment 6:  DEEM-FCID™ chronic exposure estimates (all commodities
excluding turf)

Attachment 7:  DEEM-FCID™ chronic residue file

Attachment 8:  DEEM-FCID™ cancer exposure estimates (all commodities
excluding turf)

Attachment 9:  DEEM-FCID™ cancer residue file will commodities
excluding turf

Attachment 10:  DEEM-FCID™ cancer exposure (all commodities excluding
pecan and turf)

Attachment 11:  DEEM-FCID™ cancer residue file (all commodities
excluding pecan and turf)

Attachment 12:  Complete Commodity Analysis of Cancer Analysis Performed
with all Crops Excluding Turf.  

CC with all attachments:  Mary Waller/Lisa Jones, RM 21 (RD; 7505P)

T. Bloem:S10945:PY:(703)605-0217:7509P

Attachment 1:  BEAD percent crop treated information

  SEQ CHAPTER \h \r 1 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON D.C., 20460

OFFICE OF

PREVENTION, PESTICIDES AND 

TOXIC SUBSTANCES

						

MEMORANDUM

SUBJECT:	Projected Percent Crop Treated for the Fungicide Tetraconazole
on Three Crops: Peanuts, Soybeans, and Sugar Beets.

FROM:	Jihad Alsadek, Economist

Science Information & Analysis Branch

Biological and Economic Analysis Division (7503P)

			

			Richard Michell, Plant Pathologist

			Biological Analysis Branch

			Biological and Economic Analysis Division (7503P)

TO:			Mary Waller, Product Manager

			Fungicide Branch

			Registration Division (7505P)

THRU:	Diann Sims, Chief

			Science Information Analysis Branch

			Biological and Economic Analysis Division (7503P)

			Arnet Jones, Chief

			Biological Analysis Branch

			Biological and Economic Analysis Division (7503P)

PRP Review: November 29, 2006

I.	SUMMARY

	This memorandum provides projected percent crop treated (PPCT) values
for tetraconazole on three crops (peanuts, soybeans, and sugar beets),
as well as the corresponding Federal Register (FR) language.  The
methodology used to produce the estimates is outlined below, along with
the analysis of additional biological information that could impact the
assessments.  The market leader approach is only used with peanuts;
other approaches are used with soybeans and sugar beets.  The registrant
Isa Gro input and expert opinions are used for soybeans, and the sugar
beet regional value is adjusted for a national one.  We have examined
all the relevant data and conclude that it is unlikely that the actual
percent crop treated (PCT) values for tetraconazole on peanuts, soybeans
and sugar beets in the next five years will exceed the PPCTs provided
for tetraconazole on these three crops. Numbers to be used in risk
analysis are shown in table 1.

Table 1. Values to be used in Risk Assessment

Crop	Chronic	Acute

Peanuts	77	88

Soybeans	27	38

Sugar Beets	70	70

II.	FR LANGUAGE

EPA estimates projected percent crop treated (PPCT) for a new pesticide
use by assuming that the percent crop treated (PCT) during the
pesticide’s initial five years of use on a specific use site will not
exceed the average PCT of the market leader (i.e., the one with the
greatest PCT) on that site.

Typically, EPA uses USDA/NASS as the primary source for PCT data.  When
a specific use site is not surveyed by USDA/NASS, EPA uses other sources
including proprietary data and calculates the PCT.  Comparisons are only
made among pesticides of the same pesticide types (i.e., the leading
fungicide on the use site is selected for comparison with the new
fungicide).  The PCTs included in the average may be for the same
pesticide, or for different pesticides, since the same, or different
pesticides, may dominate for each year selected.    This PPCT, based on
the average PCT of the market leader, is appropriate for use in chronic
dietary risk assessment. The method of estimating a PPCT for a new use
of a registered pesticide or a new pesticide produces a high-end
estimate that is unlikely, in most cases, to be exceeded during the
initial five years of actual use.  

The predominant factors that bear on whether the estimated PPCT could be
exceeded are whether new pesticide use or new pesticide is more
efficacious or controls a broader spectrum of pests than the dominant
pesticide; and/or whether there are concerns with pest pressures as
indicated in emergency exemption requests or other readily available
information; and/or other factor based on analysis of additional
information, such as the total crop acreage and the geographical
distribution of the crops and pests.

All information currently available for the predominant factors
mentioned above or relevant to the case in question have been considered
for this chemical, and it is the opinion of BEAD that it is unlikely
that actual PCT for tetraconazole will exceed the PPCT during the next
five years.  

III.	PROJECTIONS BASED ON MARKET LEADER APPROACH

The PPCTs for peanuts are calculated by averaging the PCTs of the
leading fungicide(s) for the three most recent available years.  The
PPCT for sugar beets showed a 55 percent use of tetraconazole as the
market leader for the year 2000, but 2000 USDA/NASS data for the market
leader tetraconazole is registered on sugar beets in seven states
(Colorado, Michigan, Minnesota, Montana, Nebraska, North Dakota, and
Wyoming).  NASS data are adjusted to get the acres treated in each of
the seven states, summing them up, then dividing by the sum of the
planted acres in these same states, and multiplying by 100 to get, on
average, market leader for sugar beets to be used in chronic dietary
risk assessment and acute risk too.

  The PPCTs for soybeans were based on a modified approach which is
described in the following subsection (Modified PPCT Approach for
Soybeans).



Table 2.  Projected Tetraconazole PCT Values for Dietary Risk
Assessments

Crop	Market Leaders	Average

Market Leader	Maximum

Market Leader	Years

Peanuts	Chlorothalonil 	77	88	1991, 1999, 2004

Soybeans	Unknown, but projected to be a triazole and/or strobilurin
fungicide	27	38	Future projection for next 5 years

Sugar Beets	Tetraconazole	70	70	Adjusted for year 2000

Sources:  Based on 1991 to 2004 NASS usage data for peanuts and sugar
beets.  Crop 

Specialists’ usage projections were used for soybeans.

  Market leaders could be the same chemical for all three years or could
be different for each year. 

b  Averaging the available years.

c  The highest observed percent crop treated of the available survey
years.

IV.         Modified PPCT Approach for Soybeans

Due to the recent discovery of a new and important disease on soybeans,
Asian soybean rust, historical information was not considered useful for
estimating a useful PCT for a fungicide market leader on soybeans. 
Another approach was utilized which involved obtaining PCT estimates for
future market leaders from soybean crop specialists.  The estimates were
obtained via a phone call and four list server responses enlisted by
USDA.  The five crop specialists’ PCT estimates for a market leader
ranged from 10 to 38 percent.  For a conservative estimate we utilized
only the maximum projected values provided by each respondent, which
ranged from 15 to 38 percent.  These values translated into average and
maximum PPCT values of 27 and 38 percent, respectively.

The most common factors used by the crop specialists to project the
market leader PCT were: weather patterns; prevailing winds; length of
time crop is in a growth stage that will lead to yield losses, if
infection occurs during this period; cost-effectiveness of treatments;
and market supply/availability limitations.  Some of the specific
examples provided to support their estimates were:

About 21% of the total soybean acreage is in areas where the prevailing
winds and temperature and humidity are generally unfavorable for soybean
rust infection (e.g., KS, ND, NE, SD).  

About 16% of the total soybean acreage doesn’t have the yield
potential to justify the cost of a soybean rust fungicide treatment.

In most years 40% of the soybean acreage is considered to possess a high
risk for soybean rust infection (e.g., IL, IN, OH, AR, eastern MO).

Pesticide distributors are more likely to carry stock of those soybean
rust fungicides that have other labeled uses relevant to area growers
(e.g., wheat  and corn uses in Midwestern states).  Note: The only
alternate crop uses for tetraconazole are sugar beets and peanuts, which
are not prevalent crops in most soybean production areas.

V.	ADDITIONAL FACTORS

Table 3. Biological Analysis of BEAD’s Projected Percent Crop Treated
(PPCT) for Tetraconazole on Three New Crops

NEW USES

[AVG. /MAX. PPCT]	RECENT MARKET LEADER(S) [SAMPLE YEARS]
JUSTIFICATION/COMMENTS	WILL TETRACONAZOLE EXCEED THE PCT LEVELS OF
MARKET LEADER(S)?

Sugar Beets – cercospora leaf spot, 

powdery mildew 

[70/70]	tetraconazole

[2000]	Tetraconazole is the current market leader (55%), and was
previously only registered for use in 7 sugar beet producing states (CO,
MI, MN, MT, NE, ND, WY); based on the 2006 acreage planted, the addition
of 4 states (CA, ID, OR, WA) increases the potential acreage to be
treated by about 18 percent;  if all the planted acreage in these 4
additional states are treated it could bring the PPCT up to about 77%;
based upon the pest information provided in the USDA Crop Profiles it is
not likely that more than 70% of the planted acreage will be treated in
any of the 4 additional states, because the reported total fungicide
usage for these target pests is less than 70%	No

Soybeans – 

Asian soybean rust, 

cercospora, 

frog eye, 

white mold, powdery mildew, septoria, anthracnose

[27/38]	Not applicable	These values seem to be reasonable estimates for
the future market leader(s) when the following factors are considered:  

1] at least 11 active ingredients are currently available and competing
for the Asian soybean rust control market on the approximately 75
million acres grown; 

2] treatments are only warranted when weather conditions conducive to
disease development occur during the soybean bloom and/or pod fill
stages; 

3] in any given year the probability of a national epidemic which
results in the need for most of the US acreage grown in the 31 soybean
producing states being treated is low, because it would be dependent
upon the widespread occurrence of unusual weather patterns during the
critical crop growth stages; 

4] The proposed labeling allows for up to two applications per year,
which if it occurs will reduce stocks and therefore reduce the total
acreage capable of being treated; Some of the crop specialists projected
that up to 30 - 40% of the acreage in their state may be treated twice.

5] the registrant stated that only one tetraconazole product will be
marketed for the soybean use because the chemical is still under patent,
which would appear to limit the amount likely to be available throughout
the US due to supply limitations and surplus stock concerns if an
epidemic does not occur;

6] The registrant (Isa Gro), per a personal phone call on November 16,
2006, stated that although they projected they might be able to treat as
much as 5.38% of the crop if an epidemic occurred; they felt it would be
impossible to supply enough tetraconazole to treat 10% of the crop
anytime within the next 5 years.

7] Since the disease organism is not considered cold-hardy, each growing
season the disease must start its northward movement from Mexico and/or
extreme southern United States locations.  Accordingly, the northward
disease spread each year and the specific states impacted is dependent
upon wind speed and direction during humid and moderate temperature
weather.  

8] EPA has approved a wide range of active ingredients and products that
can be available to growers.  This effort was initiated because of
national concern that the supply of fungicides would not be adequate in
the case of a soybean rust epidemic.  This involved granting numerous
states permission to use seven active ingredients via Section 18
quarantine emergency exemptions, in addition to the four active
ingredients already available via Section 3 registrations.

9] Based on yields obtained in recent soybean rust efficacy studies
conducted in the US and other countries the triazole and strobilurin
fungicide classes generally seem to be the most efficacious groups of
fungicides to use (Fungicide & Nematicide Tests – Special Section on
Asian Soybean Rust Reports;   HYPERLINK
"http://www.apsnet.org/online/FNtests/" 
http://www.apsnet.org/online/FNtests/ ).  Most crop specialists predict
combinations of these two types of fungicides will be used by many
growers.

10] Since the competing fungicide tebuconazole is reportedly among the
least expensive fungicides, as well as one of the most effective
triazole fungicides, it is generally considered by crop specialists to
be the triazole fungicide of choice.  Since there are multiple products
(alone and in combinations with other fungicides) being sold by
different companies reasonable stocks are expected to be available in
most soybean production areas. 

11] Crop specialists projected that the maximum US soybean acreage to be
treated with a fungicide, if an epidemic occurred, would range from
35-65 percent (average = 54%).  Therefore if one of the eleven active
ingredients available were able to attain a 50% market share this would
only result in a maximum of 32.5% of the crop being treated with any one
fungicide.  BEAD contends that this level of market share is rarely
achieved when a number of competitive active ingredients are available. 
	No,  plus the likelihood of an epidemic although uncertain is thought
to be low

Peanuts – 

early leaf spot, late leaf spot, 

web blotch, 

rust [77/88]	chlorothalonil [ 1991, 1999, 2004]	The market leader
chlorothalonil is  typically inexpensive and is used mainly for control
of the same pests that are claimed on the proposed tetraconazole label
plus the common and important disease white mold (southern stem rot);
chlorothalonil is alternated with various systemic fungicides to delay
the development of resistant pest strains; the introduction of the
systemic fungicide tetraconazole will not likely affect
chlorothalonil’s current usage, but it is expected to share the
existing systemic fungicide market	No

VI. CONCLUSIONS/RECOMMENDATIONS

BEAD recommends that the given average PPCTs be used in the chronic
dietary risk assessment for tetraconazole, and the maximum PPCTs for
acute risk assessment.  BEAD has considered all relevant information and
believes it is unlikely that the above PPCTs will be exceeded during the
next five years for peanuts, soybeans, and sugar beets.

VII. References:

Typically, EPA uses USDA/NASS as the source for raw PCT data because it
is publicly available and does not have to be calculated from available
data sources.  When a specific use site is not surveyed by USDA/NASS,
EPA uses proprietary data and calculates the estimated PCT.

Agricultural Chemical Usage, 1990 Field Crops Summary, May 1991

Agricultural Chemical Usage, 1998 Field Crops Summary, May 1999

Agricultural Chemical Usage, 1999 Field Crops Summary, May 2000

Agricultural Chemical Usage, 2004 Field Crops Summary, May 2005

USDA, 1999, Crop Profile for Sugar Beet in California.   HYPERLINK
"http://www.ipmcenters.org/cropprofiles/docs/casugarbeets.html" 
http://www.ipmcenters.org/cropprofiles/docs/casugarbeets.html 

USDA, 2000. Crop Profile for Sugar Beet in Idaho.   HYPERLINK
"http://www.ipmcenters.org/cropprofiles/docs/IDsugarbeets.html" 
http://www.ipmcenters.org/cropprofiles/docs/IDsugarbeets.html 

USDA, 1999, Crop Profile for Sugar Beet in Oregon.   HYPERLINK
"http://www.ipmcenters.org/cropprofiles/docs/orsugarbeets.html" 
http://www.ipmcenters.org/cropprofiles/docs/orsugarbeets.html 

USDA, 2001, Crop Profile for Sugar Beet in Washington.   HYPERLINK
"http://www.ipmcenters.org/cropprofiles/docs/WAsugarbeets.html" 
http://www.ipmcenters.org/cropprofiles/docs/WAsugarbeets.html 

Attachment 2:  DEEM-FCID™ acute exposure estimates (all commodities) 

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for TETRACONAZOLE                      
(1994-98 data)

Residue file: 120603a.R98                         Adjustment factor #2
NOT used.

Analysis Date: 12-07-2006/12:55:44    Residue file dated:
12-07-2006/12:54:51/8

Daily totals for food and foodform consumption used.

Run Comment: "acute for females 13-50 only FQPA SF = 1x (acute and
chronic)"

========================================================================
=======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
-------

Females 13+ (preg/not nursing):

                    0.006467     2.87    0.007195     3.20    0.009582  
 4.26 

Females 13+ (nursing):

                    0.007715     3.43    0.011025     4.90    0.013018  
 5.79 

Females 13-19 (not preg or nursing):

                    0.005535     2.46    0.008239     3.66    0.013633  
 6.06 

Females 20+ (not preg or nursing):

                    0.006025     2.68    0.009208     4.09    0.016783  
 7.46 

Females 13-50 yrs:

                    0.006169     2.74    0.009939     4.42    0.016864  
 7.50 

Females 13-49 yrs:

DEEM-FCID™ acute exposure estimates (all commodities excluding turf)

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for TETRACONAZOLE                      
(1994-98 data)

Residue file: 120603a all commodities excluding turf.R98

Adjustment factor #2 NOT used.

Analysis Date: 01-08-2007/14:43:01    Residue file dated:
01-08-2007/14:36:36/8

Daily totals for food and foodform consumption used.

Run Comment: "acute for females 13-50 only FQPA SF = 1x (acute and
chronic)"

========================================================================
=======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
--------

Females 13+ (preg/not nursing):

                    0.002093     0.93    0.002353     1.05    0.002403  
  1.07 

Females 13+ (nursing):

                    0.002123     0.94    0.002901     1.29    0.002978  
  1.32 

Females 13-19 (not preg or nursing):

                    0.001517     0.67    0.001959     0.87    0.002788  
  1.24 

Females 20+ (not preg or nursing):

                    0.001483     0.66    0.002108     0.94    0.003257  
  1.45 

Females 13-50 yrs:

                    0.001599     0.71    0.002223     0.99    0.003279  
  1.46 

Females 13-49 yrs:

                    0.001603     0.71    0.002228     0.99    0.003275  
  1.46 

:  DEEM-FCID™ acute residue file

Filename: C:\Documents and Settings\tbloem\tetraconazole\120603a.R98

Chemical: tetraconazole

RfD(Chronic): .0073 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .225 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day Q*= .023

Date created/last modified: 12-07-2006/12:20:49/8          Program ver.
2.03

Comment: acute for females 13-50 only FQPA SF = 1x (acute and chronic)

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

95002630 O    Peanut                             0.038000   1.000  1.000
 

95002640 O    Peanut, butter                     0.038000   1.890  1.000
 

95002650 O    Peanut, oil                        0.126000   1.000  1.000
 

86010000 O    Water, direct, all sources         0.118000   1.000  1.000
 

86020000 O    Water, indirect, all sources       0.118000   1.000  1.000
 

21000440 M    Beef, meat                         0.010000   1.000  1.000
 

21000441 M    Beef, meat-babyfood                0.010000   1.000  1.000
 

21000450 M    Beef, meat, dried                  0.010000   1.920  1.000
 

21000460 M    Beef, meat byproducts              0.010000   1.000  1.000
 

21000461 M    Beef, meat byproducts-babyfood     0.010000   1.000  1.000
 

21000470 M    Beef, fat                          0.020000   1.000  1.000
 

21000471 M    Beef,fat-babyfood                  0.020000   1.000  1.000
 

21000480 M    Beef, kidney                       0.010000   1.000  1.000
 

21000490 M    Beef, liver                        0.203000   1.000  1.000
 

21000491 M    Beef, liver-babyfood               0.203000   1.000  1.000
 

23001690 M    Goat, meat                         0.010000   1.000  1.000
 

23001700 M    Goat, meat byproducts              0.010000   1.000  1.000
 

23001710 M    Goat, fat                          0.020000   1.000  1.000
 

23001720 M    Goat, kidney                       0.010000   1.000  1.000
 

23001730 M    Goat, liver                        0.203000   1.000  1.000
 

24001890 M    Horse, meat                        0.010000   1.000  1.000
 

28002210 M    Meat, game                         0.010000   1.000  1.000
 

25002900 M    Pork, meat                         0.010000   1.000  1.000
 

25002901 M    Pork, meat-babyfood                0.010000   1.000  1.000
 

25002910 M    Pork, skin                         0.010000   1.000  1.000
 

25002920 M    Pork, meat byproducts              0.010000   1.000  1.000
 

25002921 M    Pork, meat byproducts-babyfood     0.010000   1.000  1.000
 

25002930 M    Pork, fat                          0.010000   1.000  1.000
 

25002931 M    Pork, fat-babyfood                 0.010000   1.000  1.000
 

25002940 M    Pork, kidney                       0.010000   1.000  1.000
 

25002950 M    Pork, liver                        0.050000   1.000  1.000
 

29003120 M    Rabbit, meat                       0.010000   1.000  1.000
 

26003390 M    Sheep, meat                        0.010000   1.000  1.000
 

26003391 M    Sheep, meat-babyfood               0.010000   1.000  1.000
 

26003400 M    Sheep, meat byproducts             0.010000   1.000  1.000
 

26003410 M    Sheep, fat                         0.020000   1.000  1.000
 

26003411 M    Sheep, fat-babyfood                0.020000   1.000  1.000
 

26003420 M    Sheep, kidney                      0.010000   1.000  1.000
 

26003430 M    Sheep, liver                       0.203000   1.000  1.000
 

40000930 P    Chicken, meat                      0.010000   1.000  1.000
 

40000931 P    Chicken, meat-babyfood             0.010000   1.000  1.000
 

40000940 P    Chicken, liver                     0.010800   1.000  1.000
 

40000950 P    Chicken, meat byproducts           0.010000   1.000  1.000
 

40000951 P    Chicken, meat byproducts-babyfoo   0.010000   1.000  1.000
 

40000960 P    Chicken, fat                       0.050000   1.000  1.000
 

40000961 P    Chicken, fat-babyfood              0.050000   1.000  1.000
 

40000970 P    Chicken, skin                      0.018700   1.000  1.000
 

40000971 P    Chicken, skin-babyfood             0.018700   1.000  1.000
 

70001450 P    Egg, whole                         0.020000   1.000  1.000
 

70001451 P    Egg, whole-babyfood                0.020000   1.000  1.000
 

70001460 P    Egg, white                         0.020000   1.000  1.000
 

70001461 P    Egg, white (solids)-babyfood       0.020000   1.000  1.000
 

70001470 P    Egg, yolk                          0.020000   1.000  1.000
 

70001471 P    Egg, yolk-babyfood                 0.020000   1.000  1.000
 

60003010 P    Poultry, other, meat               0.010000   1.000  1.000
 

60003020 P    Poultry, other, liver              0.010800   1.000  1.000
 

60003030 P    Poultry, other, meat byproducts    0.010000   1.000  1.000
 

60003040 P    Poultry, other, fat                0.050000   1.000  1.000
 

60003050 P    Poultry, other, skin               0.018700   1.000  1.000
 

50003820 P    Turkey, meat                       0.010000   1.000  1.000
 

50003821 P    Turkey, meat-babyfood              0.010000   1.000  1.000
 

50003830 P    Turkey, liver                      0.010800   1.000  1.000
 

50003831 P    Turkey, liver-babyfood             0.010800   1.000  1.000
 

50003840 P    Turkey, meat byproducts            0.010000   1.000  1.000
 

50003841 P    Turkey, meat byproducts-babyfood   0.010000   1.000  1.000
 

50003850 P    Turkey, fat                        0.050000   1.000  1.000
 

50003851 P    Turkey, fat-babyfood               0.050000   1.000  1.000
 

50003860 P    Turkey, skin                       0.018700   1.000  1.000
 

50003861 P    Turkey, skin-babyfood              0.018700   1.000  1.000
 

27002220 D    Milk, fat                          0.250000   1.000  1.000
 

27002221 D    Milk, fat - baby food/infant for   0.250000   1.000  1.000
 

27012230 D    Milk, nonfat solids                0.010000   1.000  1.000
 

27012231 D    Milk, nonfat solids-baby food/in   0.010000   1.000  1.000
 

27022240 D    Milk, water                        0.010000   1.000  1.000
 

27022241 D    Milk, water-babyfood/infant form   0.010000   1.000  1.000
 

27032251 D    Milk, sugar (lactose)-baby food/   0.010000   1.000  1.000
 

01010520 1A   Beet, sugar                        0.063000   1.000  1.000
 

01010521 1A   Beet, sugar-babyfood               0.063000   1.000  1.000
 

01010530 1A   Beet, sugar, molasses              0.189000   1.000  1.000
 

01010531 1A   Beet, sugar, molasses-babyfood     0.189000   1.000  1.000
 

06003470 6    Soybean, seed                      0.150000   1.000  1.000
 

06003480 6    Soybean, flour                     0.150000   1.000  1.000
 

06003481 6    Soybean, flour-babyfood            0.150000   1.000  1.000
 

06003490 6    Soybean, soy milk                  0.150000   1.000  1.000
 

06003491 6    Soybean, soy milk-babyfood or in   0.150000   1.000  1.000
 

06003500 6    Soybean, oil                       0.800000   1.000  1.000
 

06003501 6    Soybean, oil-babyfood              0.800000   1.000  1.000
 

14002690 14   Pecan                              0.050000   1.000  1.000
 

:  DEEM-FCID™ chronic exposure estimates (all commodities) 

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for TETRACONAZOLE                    (1994-98
data)

Residue file name: C:\Documents and
Settings\tbloem\tetraconazole\120603c.R98

                                                     Adjustment factor
#2 used.

Analysis Date 12-11-2006/12:39:33     Residue file dated:
12-11-2006/12:32:37/8

Reference dose (RfD, Chronic) = .0073 mg/kg bw/day

COMMENT 1: acute for females 13-50 only FQPA SF = 1x (acute and chronic)

========================================================================
======

                    Total exposure by population subgroup

------------------------------------------------------------------------
------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.001724               
23.6%

U.S. Population (spring season)             0.001711               
23.4%

U.S. Population (summer season)             0.001842               
25.2%

U.S. Population (autumn season)             0.001670               
22.9%

U.S. Population (winter season)             0.001672               
22.9%

Northeast region                            0.001575               
21.6%

Midwest region                              0.001748               
23.9%

Southern region                             0.001643               
22.5%

Western region                              0.001962               
26.9%

Hispanics                                   0.001946               
26.7%

Non-hispanic whites                         0.001683               
23.1%

Non-hispanic blacks                         0.001649               
22.6%

Non-hisp/non-white/non-black                0.002095               
28.7%

All infants (< 1 year)                      0.005564               
76.2%

Nursing infants                             0.002054               
28.1%

Non-nursing infants                         0.006896               
94.5%

Children 1-6  yrs                           0.002485               
34.0%

Children 7-12 yrs                           0.001628               
22.3%

Females 13-19 (not preg or nursing)         0.001232               
16.9%

Females 20+ (not preg or nursing)           0.001690               
23.1%

Females 13-50 yrs                           0.001653               
22.6%

Females 13+ (preg/not nursing)              0.001672               
22.9%

Females 13+ (nursing)                       0.002340               
32.1%

Males 13-19 yrs                             0.001310               
17.9%

Males 20+ yrs                               0.001537               
21.0%

Seniors 55+                                 0.001658               
22.7%

Children 1-2 yrs                            0.002629               
36.0%

Children 3-5 yrs                            0.002480               
34.0%

Children 6-12 yrs                           0.001717               
23.5%

Youth 13-19 yrs                             0.001276               
17.5%

Adults 20-49 yrs                            0.001597               
21.9%

Adults 50+ yrs                              0.001660               
22.7%

Females 13-49 yrs                           0.001587               
21.7%

------------------------------------------------------------------------
------

:  DEEM-FCID™ chronic exposure estimates (all commodities excluding
turf) 

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for TETRACONAZOLE                    (1994-98
data)

Residue file name: C:\Documents and
Settings\tbloem\tetraconazole\120603c all commodities excluding turf.R98
                            Adjustment factor #2 used.

Analysis Date 01-08-2007/14:44:43     Residue file dated:
01-08-2007/14:37:28/8

Reference dose (RfD, Chronic) = .0073 mg/kg bw/day

COMMENT 1: acute for females 13-50 only FQPA SF = 1x (acute and chronic)

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.000252                
3.4%

U.S. Population (spring season)             0.000251                
3.4%

U.S. Population (summer season)             0.000260                
3.6%

U.S. Population (autumn season)             0.000246                
3.4%

U.S. Population (winter season)             0.000249                
3.4%

Northeast region                            0.000232                
3.2%

Midwest region                              0.000259                
3.5%

Southern region                             0.000243                
3.3%

Western region                              0.000274                
3.8%

Hispanics                                   0.000274                
3.8%

Non-hispanic whites                         0.000246                
3.4%

Non-hispanic blacks                         0.000251                
3.4%

Non-hisp/non-white/non-black                0.000289                
4.0%

All infants (< 1 year)                      0.000735               
10.1%

Nursing infants                             0.000263                
3.6%

Non-nursing infants                         0.000915               
12.5%

Children 1-6  yrs                           0.000427                
5.9%

Children 7-12 yrs                           0.000290                
4.0%

Females 13-19 (not preg or nursing)         0.000196                
2.7%

Females 20+ (not preg or nursing)           0.000220                
3.0%

Females 13-50 yrs                           0.000228                
3.1%

Females 13+ (preg/not nursing)              0.000240                
3.3%

Females 13+ (nursing)                       0.000300                
4.1%

Males 13-19 yrs                             0.000226                
3.1%

Males 20+ yrs                               0.000217                
3.0%

Seniors 55+                                 0.000212                
2.9%

Children 1-2 yrs                            0.000442                
6.0%

Children 3-5 yrs                            0.000432                
5.9%

Children 6-12 yrs                           0.000305                
4.2%

Youth 13-19 yrs                             0.000212                
2.9%

Adults 20-49 yrs                            0.000222                
3.0%

Adults 50+ yrs                              0.000213                
2.9%

Females 13-49 yrs                           0.000218                
3.0%

------------------------------------------------------------------------
-------

:  DEEM-FCID™ chronic residue file

Filename: C:\Documents and Settings\tbloem\tetraconazole\120603c.R98

Chemical: tetraconazole

RfD(Chronic): .0073 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .225 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day Q*= .023

Date created/last modified: 12-11-2006/12:32:37/8          Program ver.
2.03

Comment: acute for females 13-50 only FQPA SF = 1x (acute and chronic)

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

95002630 O    Peanut                             0.016000   1.000  1.000
 

95002640 O    Peanut, butter                     0.016000   1.890  1.000
 

95002650 O    Peanut, oil                        0.055000   1.000  1.000
 

86010000 O    Water, direct, all sources         0.077130   1.000  1.000
 

86020000 O    Water, indirect, all sources       0.077130   1.000  1.000
 

21000440 M    Beef, meat                         0.000114   1.000  1.000
 

21000441 M    Beef, meat-babyfood                0.000114   1.000  1.000
 

21000450 M    Beef, meat, dried                  0.000114   1.920  1.000
 

21000460 M    Beef, meat byproducts              0.000596   1.000  1.000
 

21000461 M    Beef, meat byproducts-babyfood     0.000596   1.000  1.000
 

21000470 M    Beef, fat                          0.001240   1.000  1.000
 

21000471 M    Beef,fat-babyfood                  0.001240   1.000  1.000
 

21000480 M    Beef, kidney                       0.000596   1.000  1.000
 

21000490 M    Beef, liver                        0.019730   1.000  1.000
 

21000491 M    Beef, liver-babyfood               0.019730   1.000  1.000
 

23001690 M    Goat, meat                         0.000114   1.000  1.000
 

23001700 M    Goat, meat byproducts              0.000596   1.000  1.000
 

23001710 M    Goat, fat                          0.001240   1.000  1.000
 

23001720 M    Goat, kidney                       0.000596   1.000  1.000
 

23001730 M    Goat, liver                        0.019730   1.000  1.000
 

24001890 M    Horse, meat                        0.000114   1.000  1.000
 

28002210 M    Meat, game                         0.000114   1.000  1.000
 

25002900 M    Pork, meat                         0.000014   1.000  1.000
 

25002901 M    Pork, meat-babyfood                0.000014   1.000  1.000
 

25002910 M    Pork, skin                         0.000149   1.000  1.000
 

25002920 M    Pork, meat byproducts              0.000072   1.000  1.000
 

25002921 M    Pork, meat byproducts-babyfood     0.000072   1.000  1.000
 

25002930 M    Pork, fat                          0.000149   1.000  1.000
 

25002931 M    Pork, fat-babyfood                 0.000149   1.000  1.000
 

25002940 M    Pork, kidney                       0.000072   1.000  1.000
 

25002950 M    Pork, liver                        0.002370   1.000  1.000
 

29003120 M    Rabbit, meat                       0.000114   1.000  1.000
 

26003390 M    Sheep, meat                        0.000114   1.000  1.000
 

26003391 M    Sheep, meat-babyfood               0.000114   1.000  1.000
 

26003400 M    Sheep, meat byproducts             0.000596   1.000  1.000
 

26003410 M    Sheep, fat                         0.001240   1.000  1.000
 

26003411 M    Sheep, fat-babyfood                0.001240   1.000  1.000
 

26003420 M    Sheep, kidney                      0.000596   1.000  1.000
 

26003430 M    Sheep, liver                       0.019730   1.000  1.000
 

40000930 P    Chicken, meat                      0.000176   1.000  1.000
 

40000931 P    Chicken, meat-babyfood             0.000176   1.000  1.000
 

40000940 P    Chicken, liver                     0.000870   1.000  1.000
 

40000950 P    Chicken, meat byproducts           0.000336   1.000  1.000
 

40000951 P    Chicken, meat byproducts-babyfoo   0.000336   1.000  1.000
 

40000960 P    Chicken, fat                       0.003304   1.000  1.000
 

40000961 P    Chicken, fat-babyfood              0.003304   1.000  1.000
 

40000970 P    Chicken, skin                      0.001378   1.000  1.000
 

40000971 P    Chicken, skin-babyfood             0.001378   1.000  1.000
 

70001450 P    Egg, whole                         0.000748   1.000  1.000
 

70001451 P    Egg, whole-babyfood                0.000748   1.000  1.000
 

70001460 P    Egg, white                         0.000748   1.000  1.000
 

70001461 P    Egg, white (solids)-babyfood       0.000748   1.000  1.000
 

70001470 P    Egg, yolk                          0.000748   1.000  1.000
 

70001471 P    Egg, yolk-babyfood                 0.000748   1.000  1.000
 

60003010 P    Poultry, other, meat               0.000176   1.000  1.000
 

60003020 P    Poultry, other, liver              0.000870   1.000  1.000
 

60003030 P    Poultry, other, meat byproducts    0.000336   1.000  1.000
 

60003040 P    Poultry, other, fat                0.003304   1.000  1.000
 

60003050 P    Poultry, other, skin               0.001378   1.000  1.000
 

50003820 P    Turkey, meat                       0.000176   1.000  1.000
 

50003821 P    Turkey, meat-babyfood              0.000176   1.000  1.000
 

50003830 P    Turkey, liver                      0.000870   1.000  1.000
 

50003831 P    Turkey, liver-babyfood             0.000870   1.000  1.000
 

50003840 P    Turkey, meat byproducts            0.000336   1.000  1.000
 

50003841 P    Turkey, meat byproducts-babyfood   0.000336   1.000  1.000
 

50003850 P    Turkey, fat                        0.003304   1.000  1.000
 

50003851 P    Turkey, fat-babyfood               0.003304   1.000  1.000
 

50003860 P    Turkey, skin                       0.001378   1.000  1.000
 

50003861 P    Turkey, skin-babyfood              0.001378   1.000  1.000
 

27002220 D    Milk, fat                          0.002825   1.000  1.000
 

27002221 D    Milk, fat - baby food/infant for   0.002825   1.000  1.000
 

27012230 D    Milk, nonfat solids                0.000113   1.000  1.000
 

27012231 D    Milk, nonfat solids-baby food/in   0.000113   1.000  1.000
 

27022240 D    Milk, water                        0.000113   1.000  1.000
 

27022241 D    Milk, water-babyfood/infant form   0.000113   1.000  1.000
 

27032251 D    Milk, sugar (lactose)-baby food/   0.000113   1.000  1.000
 

01010520 1A   Beet, sugar                        0.002500   1.000  1.000
 

01010521 1A   Beet, sugar-babyfood               0.002500   1.000  1.000
 

01010530 1A   Beet, sugar, molasses              0.071000   1.000  1.000
 

01010531 1A   Beet, sugar, molasses-babyfood     0.071000   1.000  1.000
 

06003470 6    Soybean, seed                      0.046000   1.000  1.000
 

06003480 6    Soybean, flour                     0.046000   1.000  1.000
 

06003481 6    Soybean, flour-babyfood            0.046000   1.000  1.000
 

06003490 6    Soybean, soy milk                  0.046000   1.000  1.000
 

06003491 6    Soybean, soy milk-babyfood or in   0.046000   1.000  1.000
 

06003500 6    Soybean, oil                       0.212000   1.000  1.000
 

06003501 6    Soybean, oil-babyfood              0.212000   1.000  1.000
 

14002690 14   Pecan                              0.009000   1.000  1.000
 

:  DEEM-FCID™ cancer exposure estimates (all commodities excluding
turf)

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for TETRACONAZOLE                    (1994-98
data)

Residue file name: C:\Documents and
Settings\tbloem\tetraconazole\120603cancer without turf.R98

                                                     Adjustment factor
#2 used.

Analysis Date 12-12-2006/15:06:28     Residue file dated:
12-12-2006/15:04:57/8

Q* = 0.023 

COMMENT 1: acute for females 13-50 only FQPA SF = 1x (acute and chronic)

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg         Lifetime risk

           Subgroup                       body wt/day       (Q*= .023)

--------------------------------------   -------------     -------------

U.S. Population (total)                     0.000134         3.09E-06

------------------------------------------------------------------------
-------

Attachment 9:  DEEM-FCID™ cancer residue file (all commodities
excluding turf)

Filename: C:\Documents and Settings\tbloem\tetraconazole\120603cancer
without turf.R98

Chemical: tetraconazole

RfD(Chronic): .0073 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .225 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day Q*= .023

Date created/last modified: 12-12-2006/14:06:38/8          Program ver.
2.03

Comment: acute for females 13-50 only FQPA SF = 1x (acute and chronic)

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

95002630 O    Peanut                             0.016000   1.000  0.770
 

95002640 O    Peanut, butter                     0.016000   1.890  0.770
 

95002650 O    Peanut, oil                        0.055000   1.000  0.770
 

86010000 O    Water, direct, all sources         0.004970   1.000  1.000
 

86020000 O    Water, indirect, all sources       0.004970   1.000  1.000
 

21000440 M    Beef, meat                         0.000114   1.000  1.000
 

21000441 M    Beef, meat-babyfood                0.000114   1.000  1.000
 

21000450 M    Beef, meat, dried                  0.000114   1.920  1.000
 

21000460 M    Beef, meat byproducts              0.000596   1.000  1.000
 

21000461 M    Beef, meat byproducts-babyfood     0.000596   1.000  1.000
 

21000470 M    Beef, fat                          0.001240   1.000  1.000
 

21000471 M    Beef,fat-babyfood                  0.001240   1.000  1.000
 

21000480 M    Beef, kidney                       0.000596   1.000  1.000
 

21000490 M    Beef, liver                        0.019730   1.000  1.000
 

21000491 M    Beef, liver-babyfood               0.019730   1.000  1.000
 

23001690 M    Goat, meat                         0.000114   1.000  1.000
 

23001700 M    Goat, meat byproducts              0.000596   1.000  1.000
 

23001710 M    Goat, fat                          0.001240   1.000  1.000
 

23001720 M    Goat, kidney                       0.000596   1.000  1.000
 

23001730 M    Goat, liver                        0.019730   1.000  1.000
 

24001890 M    Horse, meat                        0.000114   1.000  1.000
 

28002210 M    Meat, game                         0.000114   1.000  1.000
 

25002900 M    Pork, meat                         0.000014   1.000  1.000
 

25002901 M    Pork, meat-babyfood                0.000014   1.000  1.000
 

25002910 M    Pork, skin                         0.000149   1.000  1.000
 

25002920 M    Pork, meat byproducts              0.000072   1.000  1.000
 

25002921 M    Pork, meat byproducts-babyfood     0.000072   1.000  1.000
 

25002930 M    Pork, fat                          0.000149   1.000  1.000
 

25002931 M    Pork, fat-babyfood                 0.000149   1.000  1.000
 

25002940 M    Pork, kidney                       0.000072   1.000  1.000
 

25002950 M    Pork, liver                        0.002370   1.000  1.000
 

29003120 M    Rabbit, meat                       0.000114   1.000  1.000
 

26003390 M    Sheep, meat                        0.000114   1.000  1.000
 

26003391 M    Sheep, meat-babyfood               0.000114   1.000  1.000
 

26003400 M    Sheep, meat byproducts             0.000596   1.000  1.000
 

26003410 M    Sheep, fat                         0.001240   1.000  1.000
 

26003411 M    Sheep, fat-babyfood                0.001240   1.000  1.000
 

26003420 M    Sheep, kidney                      0.000596   1.000  1.000
 

26003430 M    Sheep, liver                       0.019730   1.000  1.000
 

40000930 P    Chicken, meat                      0.000176   1.000  1.000
 

40000931 P    Chicken, meat-babyfood             0.000176   1.000  1.000
 

40000940 P    Chicken, liver                     0.000870   1.000  1.000
 

40000950 P    Chicken, meat byproducts           0.000336   1.000  1.000
 

40000951 P    Chicken, meat byproducts-babyfoo   0.000336   1.000  1.000
 

40000960 P    Chicken, fat                       0.003304   1.000  1.000
 

40000961 P    Chicken, fat-babyfood              0.003304   1.000  1.000
 

40000970 P    Chicken, skin                      0.001378   1.000  1.000
 

40000971 P    Chicken, skin-babyfood             0.001378   1.000  1.000
 

70001450 P    Egg, whole                         0.000748   1.000  1.000
 

70001451 P    Egg, whole-babyfood                0.000748   1.000  1.000
 

70001460 P    Egg, white                         0.000748   1.000  1.000
 

70001461 P    Egg, white (solids)-babyfood       0.000748   1.000  1.000
 

70001470 P    Egg, yolk                          0.000748   1.000  1.000
 

70001471 P    Egg, yolk-babyfood                 0.000748   1.000  1.000
 

60003010 P    Poultry, other, meat               0.000176   1.000  1.000
 

60003020 P    Poultry, other, liver              0.000870   1.000  1.000
 

60003030 P    Poultry, other, meat byproducts    0.000336   1.000  1.000
 

60003040 P    Poultry, other, fat                0.003304   1.000  1.000
 

60003050 P    Poultry, other, skin               0.001378   1.000  1.000
 

50003820 P    Turkey, meat                       0.000176   1.000  1.000
 

50003821 P    Turkey, meat-babyfood              0.000176   1.000  1.000
 

50003830 P    Turkey, liver                      0.000870   1.000  1.000
 

50003831 P    Turkey, liver-babyfood             0.000870   1.000  1.000
 

50003840 P    Turkey, meat byproducts            0.000336   1.000  1.000
 

50003841 P    Turkey, meat byproducts-babyfood   0.000336   1.000  1.000
 

50003850 P    Turkey, fat                        0.003304   1.000  1.000
 

50003851 P    Turkey, fat-babyfood               0.003304   1.000  1.000
 

50003860 P    Turkey, skin                       0.001378   1.000  1.000
 

50003861 P    Turkey, skin-babyfood              0.001378   1.000  1.000
 

27002220 D    Milk, fat                          0.002825   1.000  1.000
 

27002221 D    Milk, fat - baby food/infant for   0.002825   1.000  1.000
 

27012230 D    Milk, nonfat solids                0.000113   1.000  1.000
 

27012231 D    Milk, nonfat solids-baby food/in   0.000113   1.000  1.000
 

27022240 D    Milk, water                        0.000018   1.000  1.000
 

27022241 D    Milk, water-babyfood/infant form   0.000018   1.000  1.000
 

27032251 D    Milk, sugar (lactose)-baby food/   0.000113   1.000  1.000
 

01010520 1A   Beet, sugar                        0.002500   1.000  0.700
 

01010521 1A   Beet, sugar-babyfood               0.002500   1.000  0.700
 

01010530 1A   Beet, sugar, molasses              0.071000   1.000  0.700
 

01010531 1A   Beet, sugar, molasses-babyfood     0.071000   1.000  0.700
 

06003470 6    Soybean, seed                      0.046000   1.000  0.270
 

06003480 6    Soybean, flour                     0.046000   1.000  0.270
 

06003481 6    Soybean, flour-babyfood            0.046000   1.000  0.270
 

06003490 6    Soybean, soy milk                  0.046000   1.000  0.270
 

06003491 6    Soybean, soy milk-babyfood or in   0.046000   1.000  0.270
 

06003500 6    Soybean, oil                       0.212000   1.000  0.270
 

06003501 6    Soybean, oil-babyfood              0.212000   1.000  0.270
 

14002690 14   Pecan                              0.009000   1.000  1.000
 

Attachment 10:  DEEM-FCID™ cancer exposure estimates (all commodities
excluding pecan and turf)

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for TETRACONAZOLE                    (1994-98
data)

Residue file name: C:\Documents and
Settings\tbloem\tetraconazole\120603cancer without pecan and turf.R98

                                                     Adjustment factor
#2 used.

Analysis Date 12-12-2006/15:07:05     Residue file dated:
12-12-2006/15:05:51/8

Q* = 0.023 

COMMENT 1: acute for females 13-50 only FQPA SF = 1x (acute and chronic)

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg         Lifetime risk

           Subgroup                       body wt/day       (Q*= .023)

--------------------------------------   -------------     -------------

U.S. Population (total)                     0.000109         2.50E-06

------------------------------------------------------------------------
-------

Attachment 11:  DEEM-FCID™ cancer residue file (all commodities
excluding pecan and turf)

Filename: C:\Documents and Settings\tbloem\tetraconazole\120603cancer
without pecan and turf.R98

Chemical: tetraconazole

RfD(Chronic): .0073 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .225 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day Q*= .023

Date created/last modified: 12-11-2006/12:36:02/8          Program ver.
2.03

Comment: acute for females 13-50 only FQPA SF = 1x (acute and chronic)

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

95002630 O    Peanut                             0.016000   1.000  0.770
 

95002640 O    Peanut, butter                     0.016000   1.890  0.770
 

95002650 O    Peanut, oil                        0.055000   1.000  0.770
 

86010000 O    Water, direct, all sources         0.003770   1.000  1.000
 

86020000 O    Water, indirect, all sources       0.003770   1.000  1.000
 

21000440 M    Beef, meat                         0.000114   1.000  1.000
 

21000441 M    Beef, meat-babyfood                0.000114   1.000  1.000
 

21000450 M    Beef, meat, dried                  0.000114   1.920  1.000
 

21000460 M    Beef, meat byproducts              0.000596   1.000  1.000
 

21000461 M    Beef, meat byproducts-babyfood     0.000596   1.000  1.000
 

21000470 M    Beef, fat                          0.001240   1.000  1.000
 

21000471 M    Beef,fat-babyfood                  0.001240   1.000  1.000
 

21000480 M    Beef, kidney                       0.000596   1.000  1.000
 

21000490 M    Beef, liver                        0.019730   1.000  1.000
 

21000491 M    Beef, liver-babyfood               0.019730   1.000  1.000
 

23001690 M    Goat, meat                         0.000114   1.000  1.000
 

23001700 M    Goat, meat byproducts              0.000596   1.000  1.000
 

23001710 M    Goat, fat                          0.001240   1.000  1.000
 

23001720 M    Goat, kidney                       0.000596   1.000  1.000
 

23001730 M    Goat, liver                        0.019730   1.000  1.000
 

24001890 M    Horse, meat                        0.000114   1.000  1.000
 

28002210 M    Meat, game                         0.000114   1.000  1.000
 

25002900 M    Pork, meat                         0.000014   1.000  1.000
 

25002901 M    Pork, meat-babyfood                0.000014   1.000  1.000
 

25002910 M    Pork, skin                         0.000149   1.000  1.000
 

25002920 M    Pork, meat byproducts              0.000072   1.000  1.000
 

25002921 M    Pork, meat byproducts-babyfood     0.000072   1.000  1.000
 

25002930 M    Pork, fat                          0.000149   1.000  1.000
 

25002931 M    Pork, fat-babyfood                 0.000149   1.000  1.000
 

25002940 M    Pork, kidney                       0.000072   1.000  1.000
 

25002950 M    Pork, liver                        0.002370   1.000  1.000
 

29003120 M    Rabbit, meat                       0.000114   1.000  1.000
 

26003390 M    Sheep, meat                        0.000114   1.000  1.000
 

26003391 M    Sheep, meat-babyfood               0.000114   1.000  1.000
 

26003400 M    Sheep, meat byproducts             0.000596   1.000  1.000
 

26003410 M    Sheep, fat                         0.001240   1.000  1.000
 

26003411 M    Sheep, fat-babyfood                0.001240   1.000  1.000
 

26003420 M    Sheep, kidney                      0.000596   1.000  1.000
 

26003430 M    Sheep, liver                       0.019730   1.000  1.000
 

40000930 P    Chicken, meat                      0.000176   1.000  1.000
 

40000931 P    Chicken, meat-babyfood             0.000176   1.000  1.000
 

40000940 P    Chicken, liver                     0.000870   1.000  1.000
 

40000950 P    Chicken, meat byproducts           0.000336   1.000  1.000
 

40000951 P    Chicken, meat byproducts-babyfoo   0.000336   1.000  1.000
 

40000960 P    Chicken, fat                       0.003304   1.000  1.000
 

40000961 P    Chicken, fat-babyfood              0.003304   1.000  1.000
 

40000970 P    Chicken, skin                      0.001378   1.000  1.000
 

40000971 P    Chicken, skin-babyfood             0.001378   1.000  1.000
 

70001450 P    Egg, whole                         0.000748   1.000  1.000
 

70001451 P    Egg, whole-babyfood                0.000748   1.000  1.000
 

70001460 P    Egg, white                         0.000748   1.000  1.000
 

70001461 P    Egg, white (solids)-babyfood       0.000748   1.000  1.000
 

70001470 P    Egg, yolk                          0.000748   1.000  1.000
 

70001471 P    Egg, yolk-babyfood                 0.000748   1.000  1.000
 

60003010 P    Poultry, other, meat               0.000176   1.000  1.000
 

60003020 P    Poultry, other, liver              0.000870   1.000  1.000
 

60003030 P    Poultry, other, meat byproducts    0.000336   1.000  1.000
 

60003040 P    Poultry, other, fat                0.003304   1.000  1.000
 

60003050 P    Poultry, other, skin               0.001378   1.000  1.000
 

50003820 P    Turkey, meat                       0.000176   1.000  1.000
 

50003821 P    Turkey, meat-babyfood              0.000176   1.000  1.000
 

50003830 P    Turkey, liver                      0.000870   1.000  1.000
 

50003831 P    Turkey, liver-babyfood             0.000870   1.000  1.000
 

50003840 P    Turkey, meat byproducts            0.000336   1.000  1.000
 

50003841 P    Turkey, meat byproducts-babyfood   0.000336   1.000  1.000
 

50003850 P    Turkey, fat                        0.003304   1.000  1.000
 

50003851 P    Turkey, fat-babyfood               0.003304   1.000  1.000
 

50003860 P    Turkey, skin                       0.001378   1.000  1.000
 

50003861 P    Turkey, skin-babyfood              0.001378   1.000  1.000
 

27002220 D    Milk, fat                          0.002825   1.000  1.000
 

27002221 D    Milk, fat - baby food/infant for   0.002825   1.000  1.000
 

27012230 D    Milk, nonfat solids                0.000113   1.000  1.000
 

27012231 D    Milk, nonfat solids-baby food/in   0.000113   1.000  1.000
 

27022240 D    Milk, water                        0.000018   1.000  1.000
 

27022241 D    Milk, water-babyfood/infant form   0.000018   1.000  1.000
 

27032251 D    Milk, sugar (lactose)-baby food/   0.000113   1.000  1.000
 

01010520 1A   Beet, sugar                        0.002500   1.000  0.700
 

01010521 1A   Beet, sugar-babyfood               0.002500   1.000  0.700
 

01010530 1A   Beet, sugar, molasses              0.071000   1.000  0.700
 

01010531 1A   Beet, sugar, molasses-babyfood     0.071000   1.000  0.700
 

06003470 6    Soybean, seed                      0.046000   1.000  0.270
 

06003480 6    Soybean, flour                     0.046000   1.000  0.270
 

06003481 6    Soybean, flour-babyfood            0.046000   1.000  0.270
 

06003490 6    Soybean, soy milk                  0.046000   1.000  0.270
 

06003491 6    Soybean, soy milk-babyfood or in   0.046000   1.000  0.270
 

06003500 6    Soybean, oil                       0.212000   1.000  0.270
 

06003501 6    Soybean, oil-babyfood              0.212000   1.000  0.270
 

Attachment 12:  Complete Commodity Analysis of Cancer Analysis
Performed with all Crops Excluding Turf.  

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for TETRACONAZOLE                    (1994-98
data)

Residue file name: C:\Documents and
Settings\tbloem\tetraconazole\120603cancer without turf.R98

                                                     Adjustment factor
#2 used.

Analysis Date 12-12-2006/15:06:41     Residue file dated:
12-12-2006/15:04:57/8

Q* = 0.023 

COMMENT 1: acute for females 13-50 only FQPA SF = 1x (acute and chronic)

========================================================================
=======

                 Complete commodity contribution analysis for 

                            U.S. Population (total)

------------------------------------------------------------------------
-------

Crop Group = (O)  Other

                                                          Exposure
analysis

                                                     
-------------------------

                               Residue   Adjustment      mg/kg   
Lifetime risk

       Food name                (ppm)      Factors    body wt/day (Q*=
.023)

---------------------------- ---------- ------------- -----------
-------------

Peanut (95002630):

   FoodForm N/S               0.016000   1.000  0.770   0.0000002     
5.48E-09

Peanut, butter (95002640):

   FoodForm N/S               0.016000   1.890  0.770   0.0000012     
2.69E-08

Peanut, oil (95002650):

   FoodForm N/S               0.055000   1.000  0.770   0.0000001     
1.81E-09

Water, direct, all sources (86010000):

   FoodForm N/S               0.004970   1.000  1.000   0.0000603     
1.39E-06

Water, indirect, all sources (86020000):

   FoodForm N/S               0.004970   1.000  1.000   0.0000444     
1.02E-06

                                                      -----------
-------------

       Crop group subtotal                              0.0001062     
2.44E-06

Crop Group = (M)  Meat

                                                          Exposure
analysis

                                                     
-------------------------

                               Residue   Adjustment      mg/kg   
Lifetime risk

       Food name                (ppm)      Factors    body wt/day (Q*=
.023)

---------------------------- ---------- ------------- -----------
-------------

Beef, meat (21000440):

   FoodForm N/S               0.000114   1.000  1.000   0.0000001     
1.89E-09

Beef, meat-babyfood (21000441):

   FoodForm N/S               0.000114   1.000  1.000   0.0000000     
9.65E-12

Beef, meat, dried (21000450):

   FoodForm N/S               0.000114   1.920  1.000   0.0000000     
9.37E-12

Beef, meat byproducts (21000460):

   FoodForm N/S               0.000596   1.000  1.000   0.0000000     
3.08E-10

Beef, meat byproducts-babyfood (21000461):

   FoodForm N/S               0.000596   1.000  1.000   0.0000000     
5.48E-14

Beef, fat (21000470):

   FoodForm N/S               0.001240   1.000  1.000   0.0000002     
4.64E-09

Beef,fat-babyfood (21000471):

   FoodForm N/S               0.001240   1.000  1.000   0.0000000     
9.07E-12

Beef, kidney (21000480):

   FoodForm N/S               0.000596   1.000  1.000   0.0000000     
6.58E-13

Beef, liver (21000490):

   FoodForm N/S               0.019730   1.000  1.000   0.0000001     
2.01E-09

Beef, liver-babyfood (21000491):

   FoodForm N/S               0.019730   1.000  1.000   0.0000000     
3.00E-11

Goat, meat (23001690):

   FoodForm N/S               0.000114   1.000  1.000   0.0000000     
6.09E-12

Goat, meat byproducts (23001700):

   FoodForm N/S               0.000596   1.000  1.000   no exposure

Goat, fat (23001710):

   FoodForm N/S               0.001240   1.000  1.000   0.0000000     
2.40E-12

Goat, kidney (23001720):

   FoodForm N/S               0.000596   1.000  1.000   no exposure

Goat, liver (23001730):

   FoodForm N/S               0.019730   1.000  1.000   no exposure

Horse, meat (24001890):

   FoodForm N/S               0.000114   1.000  1.000   no exposure

Meat, game (28002210):

   FoodForm N/S               0.000114   1.000  1.000   0.0000000     
2.50E-11

Pork, meat (25002900):

   FoodForm N/S               0.000014   1.000  1.000   0.0000000     
9.91E-11

Pork, meat-babyfood (25002901):

   FoodForm N/S               0.000014   1.000  1.000   0.0000000     
3.55E-13

Pork, skin (25002910):

   FoodForm N/S               0.000149   1.000  1.000   0.0000000     
8.94E-12

Pork, meat byproducts (25002920):

   FoodForm N/S               0.000072   1.000  1.000   0.0000000     
3.46E-11

Pork, meat byproducts-babyfood (25002921):

   FoodForm N/S               0.000072   1.000  1.000   0.0000000     
6.62E-15

Pork, fat (25002930):

   FoodForm N/S               0.000149   1.000  1.000   0.0000000     
2.87E-10

Pork, fat-babyfood (25002931):

   FoodForm N/S               0.000149   1.000  1.000   0.0000000     
3.94E-13

Pork, kidney (25002940):

   FoodForm N/S               0.000072   1.000  1.000   0.0000000     
5.80E-14

Pork, liver (25002950):

   FoodForm N/S               0.002370   1.000  1.000   0.0000000     
5.18E-11

Rabbit, meat (29003120):

   FoodForm N/S               0.000114   1.000  1.000   0.0000000     
7.53E-13

Sheep, meat (26003390):

   FoodForm N/S               0.000114   1.000  1.000   0.0000000     
1.37E-11

Sheep, meat-babyfood (26003391):

   FoodForm N/S               0.000114   1.000  1.000   0.0000000     
1.05E-13

Sheep, meat byproducts (26003400):

   FoodForm N/S               0.000596   1.000  1.000   0.0000000     
7.27E-13

Sheep, fat (26003410):

   FoodForm N/S               0.001240   1.000  1.000   0.0000000     
3.07E-11

Sheep, fat-babyfood (26003411):

   FoodForm N/S               0.001240   1.000  1.000   0.0000000     
5.70E-14

Sheep, kidney (26003420):

   FoodForm N/S               0.000596   1.000  1.000   0.0000000     
1.37E-14

Sheep, liver (26003430):

   FoodForm N/S               0.019730   1.000  1.000   0.0000000     
4.54E-13

                                                      -----------
-------------

       Crop group subtotal                              0.0000004     
9.47E-09



Crop Group = (P)  Poultry

                                                          Exposure
analysis

                                                     
-------------------------

                               Residue   Adjustment      mg/kg   
Lifetime risk

       Food name                (ppm)      Factors    body wt/day (Q*=
.023)

---------------------------- ---------- ------------- -----------
-------------

Chicken, meat (40000930):

   FoodForm N/S               0.000176   1.000  1.000   0.0000001     
1.86E-09

Chicken, meat-babyfood (40000931):

   FoodForm N/S               0.000176   1.000  1.000   0.0000000     
2.02E-11

Chicken, liver (40000940):

   FoodForm N/S               0.000870   1.000  1.000   0.0000000     
2.32E-11

Chicken, meat byproducts (40000950):

   FoodForm N/S               0.000336   1.000  1.000   0.0000000     
1.00E-10

Chicken, meat byproducts-babyfood (40000951):

   FoodForm N/S               0.000336   1.000  1.000   0.0000000     
1.24E-12

Chicken, fat (40000960):

   FoodForm N/S               0.003304   1.000  1.000   0.0000002     
3.78E-09

Chicken, fat-babyfood (40000961):

   FoodForm N/S               0.003304   1.000  1.000   0.0000000     
3.94E-11

Chicken, skin (40000970):

	

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  0.000748   1.000  1.000   0.0000003      6.40E-09

Egg, whole-babyfood (70001451):

   FoodForm N/S               0.000748   1.000  1.000   0.0000000     
1.69E-12

Egg, white (70001460):

   FoodForm N/S               0.000748   1.000  1.000   0.0000000     
2.77E-10

Egg, white (solids)-babyfood (70001461):

   FoodForm N/S               0.000748   1.000  1.000   no exposure

Egg, yolk (70001470):

   FoodForm N/S               0.000748   1.000  1.000   0.0000000     
1.35E-10

Egg, yolk-babyfood (70001471):

   FoodForm N/S               0.000748   1.000  1.000   0.0000000     
2.49E-12

Poultry, other, meat (60003010):

   FoodForm N/S               0.000176   1.000  1.000   0.0000000     
9.59E-12

Poultry, other, liver (60003020):

   FoodForm N/S               0.000870   1.000  1.000   0.0000000     
4.80E-13

Poultry, other, meat byproducts (60003030):

   FoodForm N/S               0.000336   1.000  1.000   0.0000000     
8.89E-13

Poultry, other, fat (60003040):

   FoodForm N/S               0.003304   1.000  1.000   0.0000000     
7.61E-11

Poultry, other, skin (60003050):

   FoodForm N/S               0.001378   1.000  1.000   0.0000000     
1.16E-11

Turkey, meat (50003820):

   FoodForm N/S               0.000176   1.000  1.000   0.0000000     
5.10E-10

Turkey, meat-babyfood (50003821):

   FoodForm N/S               0.000176   1.000  1.000   0.0000000     
1.15E-11

Turkey, liver (50003830):

   FoodForm N/S               0.000870   1.000  1.000   0.0000000     
5.80E-12

Turkey, liver-babyfood (50003831):

   FoodForm N/S               0.000870   1.000  1.000   no exposure

Turkey, meat byproducts (50003840):

   FoodForm N/S               0.000336   1.000  1.000   0.0000000     
5.06E-11

Turkey, meat byproducts-babyfood (50003841):

   FoodForm N/S               0.000336   1.000  1.000   0.0000000     
6.88E-13

Turkey, fat (50003850):

   FoodForm N/S               0.003304   1.000  1.000   0.0000000     
1.06E-09

Turkey, fat-babyfood (50003851):

   FoodForm N/S               0.003304   1.000  1.000   0.0000000     
1.51E-11

Turkey, skin (50003860):

   FoodForm N/S               0.001378   1.000  1.000   0.0000000     
2.12E-10

Turkey, skin-babyfood (50003861):

   FoodForm N/S               0.001378   1.000  1.000   0.0000000     
3.80E-12

                                                      -----------
-------------

       Crop group subtotal                              0.0000007     
1.54E-08

Crop Group = (D)  Dairy Products

                                                          Exposure
analysis

                                                     
-------------------------

                               Residue   Adjustment      mg/kg   
Lifetime risk

       Food name                (ppm)      Factors    body wt/day (Q*=
.023)

---------------------------- ---------- ------------- -----------
-------------

Milk, fat (27002220):

   FoodForm N/S               0.002825   1.000  1.000   0.0000009     
2.16E-08

Milk, fat - baby food/infant formula (27002221):

   FoodForm N/S               0.002825   1.000  1.000   0.0000000     
1.22E-11

Milk, nonfat solids (27012230):

   FoodForm N/S               0.000113   1.000  1.000   0.0000001     
1.92E-09

Milk, nonfat solids-baby food/infant fo (27012231):

   FoodForm N/S               0.000113   1.000  1.000   0.0000000     
4.84E-11

Milk, water (27022240):

   FoodForm N/S               0.000018   1.000  1.000   0.0000001     
2.28E-09

Milk, water-babyfood/infant formula (27022241):

   FoodForm N/S               0.000018   1.000  1.000   0.0000000     
7.52E-13

Milk, sugar (lactose)-baby food/infant (27032251):

   FoodForm N/S               0.000113   1.000  1.000   0.0000000     
2.04E-10

                                                      -----------
-------------

       Crop group subtotal                              0.0000011     
2.60E-08

Crop Group = (1)  Root and Tuber Vegetables

                                                          Exposure
analysis

                                                     
-------------------------

                               Residue   Adjustment      mg/kg   
Lifetime risk

       Food name                (ppm)      Factors    body wt/day (Q*=
.023)

---------------------------- ---------- ------------- -----------
-------------

Beet, sugar (01010520):

   FoodForm N/S               0.002500   1.000  0.700   0.0000005     
1.16E-08

Beet, sugar-babyfood (01010521):

   FoodForm N/S               0.002500   1.000  0.700   0.0000000     
1.47E-10

Beet, sugar, molasses (01010530):

   FoodForm N/S               0.071000   1.000  0.700   0.0000001     
2.62E-09

Beet, sugar, molasses-babyfood (01010531):

   FoodForm N/S               0.071000   1.000  0.700   0.0000000     
1.71E-11

                                                      -----------
-------------

       Crop group subtotal                              0.0000006     
1.44E-08

Crop Group = (6)  Legume Vegetables (Succulent or Dried)

                                                          Exposure
analysis

                                                     
-------------------------

                               Residue   Adjustment      mg/kg   
Lifetime risk

       Food name                (ppm)      Factors    body wt/day (Q*=
.023)

---------------------------- ---------- ------------- -----------
-------------

Soybean, seed (06003470):

   FoodForm N/S               0.046000   1.000  0.270   0.0000000     
9.87E-10

Soybean, flour (06003480):

   FoodForm N/S               0.046000   1.000  0.270   0.0000002     
3.52E-09

Soybean, flour-babyfood (06003481):

   FoodForm N/S               0.046000   1.000  0.270   0.0000001     
1.37E-09

Soybean, soy milk (06003490):

   FoodForm N/S               0.046000   1.000  0.270   0.0000003     
6.21E-09

Soybean, soy milk-babyfood or infant fo (06003491):

   FoodForm N/S               0.046000   1.000  0.270   no exposure

Soybean, oil (06003500):

   FoodForm N/S               0.212000   1.000  0.270   0.0000238     
5.47E-07

Soybean, oil-babyfood (06003501):

   FoodForm N/S               0.212000   1.000  0.270   0.0000008     
1.85E-08

                                                      -----------
-------------

       Crop group subtotal                              0.0000251     
5.77E-07

Crop Group = (14) Tree Nuts

                                                          Exposure
analysis

                                                     
-------------------------

                               Residue   Adjustment      mg/kg   
Lifetime risk

       Food name                (ppm)      Factors    body wt/day (Q*=
.023)

---------------------------- ---------- ------------- -----------
-------------

Pecan (14002690):

   FoodForm N/S               0.009000   1.000  1.000   0.0000000     
2.81E-10

                                                      -----------
-------------

       Crop group subtotal                              0.0000000     
2.81E-10

     Population subgroup total                          0.0001342     
3.09E-06

------------------------------------------------------------------------
-------

Tetraconazole	Dietary Exposure and Risk Assessment	D321637

Page   PAGE  4  of   NUMPAGES  38 

Page   PAGE  38  of   NUMPAGES  38