Document ID: EPA-HQ-OPP-2005-0258-0043
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2006-08-30T04:00Z

Triadimefon
&
Triadimenol
Aggregate
Risk
Assessment
­
RED
DP
Barcode:
331455
Page
1
of
21
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES,

AND
TOXIC
SUBSTANCES
MEMORANDUM
Date:
August
1,
2006
Subject:
Triadimefon
&
Triadimenol:
Aggregate
Acute,
Chronic,
and
Short­
Term
Risk
Assessments
Reflecting
July,
2006
Risk
Mitigation
in
Response
to
the
Phase
4
Triadimefon
RED.

DP
Barcode:
D331455
PC
Codes:
109901
and
127201
40
CFR
§
:
180.410
Chemical
Class:
Azole
From:
Yvonne
Barnes,
Chemist
Reregistration
Branch
II
and
Sheila
Piper,
Chemist
Chemistry
and
Exposure
Branch
Health
Effects
Division
(
7509P)

Through:
William
J.
Hazel,
Branch
Chief
Reregistration
Branch
II
Health
Effects
Division
(
7509P)

To:
Richard
Griffin,
Risk
Assessor
Reregistration
Branch
II
Health
Effects
Division
(
7509P)
and
John
Pates,
Chemical
Review
Manager
Reregistration
Branch
I
Special
Review
and
Reregistration
Division
(
7508P)
Triadimefon
&
Triadimenol
Aggregate
Risk
Assessment
­
RED
DP
Barcode:
331455
Page
2
of
21
Executive
Summary
Revised
acute
and
chronic
aggregate
dietary
(
triadimefon
and
triadimenol)
food
and
water
exposure
and
risk
assessments
were
conducted
using
the
Dietary
Exposure
Evaluation
Model
software
with
the
Food
Commodity
Intake
Database
(
DEEM­
FCID
 
,
Version
2.03),
which
uses
food
consumption
data
from
the
U.
S.
Department
of
Agriculture's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII)
from
1994­
1996
and
1998.
The
analyses
were
performed
in
response
to
the
registrant,
Bayer
CropScience's
agreement
to
voluntarily
cancel
all
food
uses,
except
for
pre­
plant
and
post­
harvest
use
on
pineapples
for
triadimefon.
Food
uses
to
be
cancelled
include
apples,
pears,
grapes,
and
raspberries
(
commercial
or
residential).
EPA
will
issue
a
6f
notice
proposing
to
cancel
these
uses;
Bayer
will
waive
the
6
month
comment
period
to
30
days.

Acute
Aggregate
Dietary
Exposure
Characterization
of
Input
Data
This
risk
assessment
represents
aggregation
of
triadimefon
and
triadimenol
residues
resulting
from
the
metabolism
of
triadimefon
as
well
as
the
use
of
triadimenol
as
an
active
ingredient.
This
dietary
exposure
and
risk
assessment
for
triadimefon
and
triadimenol
includes
the
following:
field
trial
data
for
pineapples
and
bananas,
seed
treatment
tolerances
for
barley,
corn,
oat,
rye,
cottonseed,
and
wheat
and
the
new
drinking
water
mitigation
proposed
by
Bayer:
two
applications
per
season
at
2.7
lb
ai/
A
and
14­
day
interval
made
to
the
entire
golf
course.
The
assessment
includes
the
time
series
data
from
the
PRZM
EXAMS
model
of
the
drinking
water
scenario.
Although
exposure
to
residue
in/
on
banana
and
pineapple
food­
forms
and
drinking
water
were
estimated
probabilistically,
100%
CT
was
used
for
all
foods
and
tolerances
were
used
(
grain
crops
and
cottonseed
products).
As
a
result,
standard
policy
is
to
evaluate
at
the
95th
percentile
since
tolerance
level
residues
and
100%
crop
treated
was
used.

Acute
Aggregate
Dietary
Exposure
Results
Acute
Aggregate
Dietary
Food
Only
Triadimefon
Food
(
pineapples
only)
+
Triadimenol
Food
(
bananas
and
seed
treatments)

The
acute
aggregate
dietary
exposure
estimates
from
food
only
are
below
HED's
level
of
concern
(<
100%
aPAD)
at
the
95th
percentile
of
exposure.
The
acute
aggregate
dietary
risk
at
the
95th
percentile
of
exposure
from
food
only
is
15%
of
the
aPAD
for
the
U.
S.
population
and
33%
of
the
aPAD
for
children
1­
2
yrs,
the
most
highly
exposed
population
subgroup.

Acute
Aggregate
Dietary
Water
Only
DW
from
2
apps
at
2.7
lb
ai/
A
to
Entire
Course
The
acute
aggregate
dietary
exposure
estimates
from
drinking
water
only
using
the
Florida
turf
(
two
applications)
for
drinking
water
are
below
HED's
level
of
concern
(<
100%
aPAD)
at
the
95th
percentile
of
exposure.
At
the
95th
percentile
of
exposure,
risks
were
estimated
to
be
24%
and
85%
of
the
aPAD
for
the
U.
S.
population
and
all
infants
(<
1
yr),
respectively.
Triadimefon
&
Triadimenol
Aggregate
Risk
Assessment
­
RED
DP
Barcode:
331455
Page
3
of
21
Acute
Aggregate
Dietary
(
food
+
water)
Triadimefon
Food
(
pineapples
only)
+
Triadimenol
Food
(
bananas
and
seed
treatments)
+
DW
from
2
apps
at
2.7
lb
ai/
A
to
Entire
Course
The
acute
aggregate
dietary
exposure
estimates
from
food
and
drinking
water
using
Florida
turf
with
two
applications
for
drinking
water
are
below
HED's
level
of
concern
(<
100%
aPAD)
at
the
95th
percentile
of
exposure.
At
the
95th
percentile
of
exposure
risks
were
estimated
to
be
33%
and
94%
of
the
aPAD
for
the
U.
S.
population
and
all
infants
(<
1
yr),
respectively.

Chronic
Aggregate
Dietary
Exposure
Results
Chronic
Dietary
Food
Only
Triadimefon
Food
(
pineapples
only)
+
Triadimenol
Food
(
bananas
and
seed
treatments)

The
chronic
aggregate
dietary
exposure
estimates
from
food
only
are
below
HED's
level
of
concern
(<
100%
cPAD)
for
the
U.
S.
population
and
all
population
subgroups.
The
chronic
aggregate
dietary
risk
from
food
only
for
the
U.
S.
population
is
6%
of
the
cPAD
and
15%
of
the
cPAD
for
children
1­
2
yrs,
the
most
highly
exposed
population
subgroup.

Chronic
Aggregate
Water
Only
DW
from
2
apps
at
2.7
lb
ai/
A
to
Entire
Course
The
chronic
aggregate
dietary
exposure
estimates
from
drinking
water
only
using
the
Florida
turf
with
two
applications,
are
below
HED's
level
of
concern
(<
100%
cPAD)
for
the
U.
S.
population
and
all
population
subgroups.
The
aggregate
dietary
risk
from
drinking
water
for
the
U.
S.
population
is
12%
of
the
cPAD
and
40%
of
the
cPAD
for
all
infants
(<
1
yr),
the
most
highly
exposed
population
subgroup.

Chronic
Aggregate
(
food
+
water)
Chronic
Aggregate
Dietary/
Triadimefon
Food
(
pineapples
only)
+
Triadimenol
Food
(
bananas
and
seed
treatments)
+
DW
from
2
apps
at
2.7
lb
ai/
A
to
Entire
Course
The
chronic
aggregate
dietary
exposure
estimates
from
food
and
drinking
water
using
Florida
turf,
two
applications
are
below
HED's
level
of
concern
(<
100%
cPAD)
for
the
U.
S.
population
and
all
population
subgroups.
The
aggregate
dietary
risk
from
food
and
drinking
water
for
the
U.
S.
population
is
18%
of
the
cPAD
and
47%
of
the
cPAD
for
all
infants
(<
1
yr),
the
most
highly
exposed
population
subgroup.

Short­
term
Aggregate
Short­
term
Aggregate
(
adults)
Application
to
ornamentals
(
azaleas)
+
chronic
dietary
+
chronic
water
The
short­
term
aggregate
risk
reflecting
residential
handler
scenarios:
Application
to
ornamentals
(
azaleas
=
worst
case
residential
handler
(
MOE
of
1100
for
dermal
+
inhalation).
The
resulting
shortterm
aggregate
has
a
MOE
of
920
which
exceeds
HED
level
of
concern.
Another
scenario
Triadimefon
&
Triadimenol
Aggregate
Risk
Assessment
­
RED
DP
Barcode:
331455
Page
4
of
21
residential
handler
(
mixer,
loader,
applicator)
for
low­
pressure
hand­
wand
application
of
a
WP
to
green
house
ornamental
has
a
MOE
of
1700
(
dermal
+
inhalation).
The
resulting
short
 
term
aggregate
MOE
is
1300.

Short­
term
Aggregate
(
toddlers)
Post­
application
exposure
to
sod
farm
turf
+
chronic
dietary
+
chronic
water
Short­
term
aggregate
for
toddlers
due
to
post­
application
exposure
to
treated
sod
(
i.
e.
sod
transplanted
to
a
residential
lawn).
The
MOE
(
combined
hand­
to­
mouth,
dermal
and
inhalation)
at
a
sod
pre­
harvest
interval
of
15
days
was
1100;
the
MOE
was
of
concern
(<
1000)
at
14
days.
The
chronic
dietary
(
food
+
water)
exposure
for
children
1­
2
years
is
a
MOE
of
3100.
The
resulting
short­
term
aggregate
MOE
was
810.

On
day
17,
the
combined
MOE's
for
toddlers
on
sod
treated
at
the
2.7
lb
a.
i./
A
rate
is
1700.
When
this
rate
is
aggregated
with
the
chronic
dietary
(
food
and
water)
MOE
of
3100
MOE,
the
resultant
aggregate
is
1100.
The
individual
MOE's
are
as
follows:
a)
Hand­
To­
Mouth
=
2500;
b)
Object­
To­
Mouth
=
10,000;
c)
Soil
=
31,000;
Dermal
=
11,000.

The
short­
term
toddler
aggregate
on
day
16
is
920.

I.
Introduction
Dietary
risk
assessment
incorporates
both
exposure
and
toxicity
of
a
given
pesticide.
For
acute
dietary,
chronic
dietary
and
aggregate
assessments,
the
risk
is
expressed
as
a
percentage
of
a
maximum
acceptable
dose
(
i.
e.,
the
dose
which
the
Health
Effects
Division
has
concluded
will
result
in
no
unreasonable
adverse
health
effects).
This
dose
is
referred
to
as
the
population
adjusted
dose
(
PAD).
The
PAD
is
equivalent
to
the
Reference
Dose
(
RfD)
divided
by
the
FQPA
Safety
Factor.

For
acute
and
non­
cancer
chronic
exposures,
HED
is
concerned
when
estimated
dietary
risk
exceeds
100%
of
the
PAD.
References
which
discuss
the
acute
and
chronic
dietary
risk
assessments
in
more
detail
are
available
on
the
EPA
pesticides
web
site:
"
Available
Information
on
Assessing
Exposure
from
Pesticides,
A
User's
Guide,"
06/
21/
2000,
web
link:
http://
www.
epa.
gov
/
fedrgstr/
EPA­
PEST
/
2000/
July/
Day­
12/
6061.
pdf;
or
see
SOP
99.6
(
08/
20/
1999).

The
two
most
recent
dietary
risk
assessments
for
triadimefon
and
triadimenol
were
conducted
by
Y.
Barnes
and
S.
Piper
(
DP
Barcode
D314778,
Revised
06­
July­
2006)
and
S.
Ary
(
DP
Barcode
D314778,
23­
NOV­
2005).

II.
Residue
Information
Tolerances
are
established
for
residues
of
triadimefon
[
1­(
4­
chlorophenoxy)­
3,
3­
dimethyl­
1­(
1H­
1,
2,
4­
triazol­
1­
yl)­
2­
butanone]
and
its
metabolites
containing
chlorophenoxy
and
triazole
moieties
(
expressed
as
the
parent
compound)
in/
on
various
plant
and
animal
commodities
[
40
CFR
§
180.410].
Triadimefon
&
Triadimenol
Aggregate
Risk
Assessment
­
RED
DP
Barcode:
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Page
5
of
21
Triadimenol,
b­(
4­
chlorophenoxy)­
a­(
1,1­
dimethylethyl)­
1H­
1,2,4­
triazole­
1­
ethanol,
is
a
systemic
fungicide
registered
for
use
in
the
United
States
as
a
seed
treatment
for
barley,
corn,
cotton,
oats,
rye,
and
wheat.
Additionally,
an
import
tolerance
on
bananas
has
been
established
[
40
CFR
§
180.450].

Bayer
CropScience
has
agreed
to
voluntarily
cancel
all
food
uses,
except
for
pre­
plant
and
postharvest
use
on
pineapples
for
triadimefon.
Food
uses
to
be
cancelled
include
apples,
pears,
grapes,
and
raspberries
(
in
both
commercial
and
residential
settings).
EPA
will
issue
a
6f
notice
proposing
to
cancel
these
uses;
Bayer
will
waive
the
6
month
comment
period
to
30
days.
Once
the
30
day
comment
period
closes,
EPA
will
issue
a
cancellation
order,
with
an
existing
stocks
provision
of
1
year
from
the
effective
date
of
cancellation.
The
associated
tolerances
will
be
proposed
for
revocation.

The
qualitative
nature
of
triadimefon
and
triadimenol
residues
in
plants
is
understood
based
on
adequate
metabolism
studies
conducted
with
grapes,
cucumbers,
tomatoes,
and
wheat.
The
Health
Effects
Division
(
HED)
Metabolism
Assessment
Review
Committee
(
MARC)
has
determined
that
the
residues
of
concern
in
plants
are
triadimefon,
triadimenol,
KWG
1323,
KWG
1342,
and,
in
wheat
only,
KWG
1732
(
S.
Knizner,
HED
MARC
memorandum,
01/
03/
1994).
Tolerances
in
poultry
commodities
are
unnecessary
for
triadimefon
as
there
are
no
treated
poultry
feed
items.
HED
concluded
that
the
then
supported
uses
on
apples,
grapes,
pears,
pineapples,
and
raspberries
result
in
a
40
CFR
§
180.6(
a)(
3)
situation
for
ruminant
commodities;
i.
e.,
there
was
and
still
is
no
reasonable
expectation
of
finite
residues
in
ruminant
commodities.
Therefore,
tolerances
in
animal
commodities
are
not
required
at
the
present
time.

Residue
Data
used
for
Acute
and
Chronic
Dietary
Assessments
The
anticipated
residue
estimates
are
based
on
field
trial
data
(
pineapples
and
bananas)
and
seed
treatment
tolerances
were
used
for
barley,
corn,
oat,
rye
and
cottonseed
and
wheat.
All
triadimefon
and
triadimenol
acute
and
chronic
residue
estimates
for
crop
commodities
are
listed
in
Table
1.
As
stated
above,
the
residues
of
concern
in
risk
assessment
include
three
of
triadimefon's
metabolites:
triadimenol,
KWG
1323,
and
KWG
1342.
Since
MARC
concluded
that
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342
are
residues
of
concern,
residue
data
for
these
metabolites
were
needed
for
conducting
a
dietary
risk
assessment.

Residue
Estimates
for
Individual
Crops
Pineapple:
Pineapple
field
trial
data
submitted
in
MRID
42342307
were
used.
A
total
of
ten
trials
were
conducted
and
samples
were
analyzed
for
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342.
The
method
LOQ
was
determined
at
0.01
ppm.
For
values
reported
below
the
LOQ,
half
the
LOQ
was
used
in
calculating
the
total
combined
residues
of
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342.
All
residue
values
were
corrected
to
1x
application
rate.
The
estimated
%
CT
for
pineapples
of
100%
was
used
for
the
acute
and
chronic
dietary
risk
assessments.

Bananas:
Banana
field
trial
data
submitted
in
MRID
40615021
were
used.
A
total
of
ten
trials
were
conducted
and
samples
were
analyzed
for
triadimefon,
triadimenol,
KWG
1323,
and
KWG
1342.
The
method
LOQ
was
determined
at
0.01
ppm.
For
values
reported
below
the
LOQ,
half
the
LOQ
was
used
in
calculating
the
total
combined
residues
of
triadimefon,
triadimenol,
KWG
1323,
and
Triadimefon
&
Triadimenol
Aggregate
Risk
Assessment
­
RED
DP
Barcode:
331455
Page
6
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21
KWG
1342.
All
residue
values
were
corrected
to
1x
application
rate.
The
estimated
%
CT
for
bananas
of
100%
was
used
for
the
acute
and
chronic
dietary
risk
assessments.

Table
1:
Triadimefon
and
Triadimenol
Data
and
Residue
Estimates
Used
in
Dietary
Analyses
Anticipated
Residue
Estimates/
Tolerance
RAC
Classification1
Data
Source
Years
No.
of
Samples
No.
of
Detects
%
CT
Avg.
2
%
CT
Max.
2
Processing
Factors3
Acute
(
Tol.,
AR,
RDF)
ppm
Chronic
(
Tol.,
AR)
ppm
Pineapple
NB
or
PB
Field
Trial
MRID
42342307
1992
10
10
100
100
dried
at
5.0
TOTALZ=
0
TOTALLOD=
0
LODRES=
0.005
0.05,
0.08,
0.10,
0.10,
0.11,
0.08,
0.09,
0.06
0.07,
0.05
AR
(
0.079)

Banana
NB
or
PB
Field
Trial
MRID
40615201
1998
10
10
100
100
dried
at
3.9
TOTALZ=
0
TOTALNZ=
10
0.04,
0.05,
0.02
0.05,
0.04,
0.015,
0.015,
0.025,
0.015,
0.03
AR
(
0.03)

Cottonseed
B
Tolerance
­­
­­
­­
100
100
­­
0.02
0.02
Cereal,
Corn
&
Grains
NB,
PB
or
B
Tolerance
­­
­­
­­
100
100
bran
at
2.1
0.05
0.05
1.
Classification
of
blended
(
B),
partially
blended
(
PB),
not
blended
(
NB).
2.
100%
CT
was
used
in
the
dietary
assessment.
3.
Processing
study
information
may
be
found
in
the
Chemistry
Review
Document,
guideline
section
860.1520
Processed
Food
and
Feed
(
S.
Ary,
D314742,
9/
16/
2005).

Processing
Factors
Data
from
the
processing
studies
were
used
in
this
assessment
for
several
commodities
along
with
DEEM
7.81
default
processing
factors
for
dried
pineapple
(
5.0x),
bananas
(
3.9x),
barley
and
oat
bran
(
2.1x).
All
other
processed
commodities
showed
little
or
no
concentration
in
the
available
processing
studies.
For
detailed
considerations
of
processing
factors
see
"
Triadimefon.
Summary
of
Analytical
Chemistry
and
Residue
Data
for
the
Reregistration
Eligibility
Decision
(
RED)
Document"
under
guideline
section
860.1520
(
S.
Ary,
D314742,
09/
16/
2005).

III.
Drinking
Water
Data
Triadimefon
&
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The
drinking
water
values
used
in
the
dietary
risk
assessment
were
provided
by
the
Environmental
Fate
and
Effects
Division
(
EFED)
in
the
following
email
correspondence
(
J.
Angier,
11­
JUL­
2006).
Water
residues
were
incorporated
in
to
DEEM­
FCID
 
food
categories
of
"
water,
direct,
all
sources"
and
"
water,
indirect,
all
sources."
The
estimated
drinking
water
concentrations
(
EDWCs)
for
triadimefon
and
triadimenol
were
moderately
refined
and
calculated
using
PRZM
(
Pesticide
Root
Zone
Model)
and
EXAMS
(
Exposure
Analysis
Modeling
System)
for
use
in
the
human
health
risk
assessment.
In
this
assessment,
the
EDWCs
were
calculated
to
reflect
Bayer's
July
2006
mitigation
proposal
to
reduce
the
golf
course
use
pattern
to
2
applications
at
2.7
lbs
ai/
A
and
a
golf
course
adjustment
factor
(
GCAFs)
was
applied
to
surface
water.
The
PRZM­
EXAMS
surface
water
modeling
data
point
estimate
from
the
1
in
10
year
annual
concentration
for
FL
turf
was
19.633
ppb
and
used
in
the
chronic
dietary
exposure
assessment.

IV.
Toxicological
Information
Both
the
acute
and
chronic
dietary
exposure
estimates
for
triadimefon
were
evaluated
based
on
a
NOAEL
of
3.4
mg/
kg/
day
from
a
subchronic
neurotoxicity
study
in
rats
(
R.
Griffin,
D325542,
23­
JAN­
2006).
The
triadimefon
risk
assessments
are
based
on
the
dietary
endpoint
only
except
for
short­
term
dermal
assessment
which
relied
on
a
21­
day
rat
dermal
toxicity
study
having
a
NOAEL
of
300
mg/
kg/
day.
There
are
no
residential
exposures
resulting
from
registered
uses
of
triadimenol.
A
summary
of
the
toxicological
doses
and
endpoints
selected
for
these
risk
assessments
is
provided
in
Table
2.

Table
2:
Summary
of
Toxicological
Doses
and
Endpoints
for
Triadimefon
and
Triadimenol
Exposure
Scenario
Dose
Used
in
Risk
Assessment,
UF
FQPA
SF*
and
Level
of
Concern
for
Risk
Assessment
Study
and
Toxicological
Effects
Acute
Dietary
(
general
population)
NOAEL
=
3.4
mg/
kg/
day
UF
=
1000
Acute
RfD
=
0.0034
mg/
kg/
day
FQPA
SF
=
1X
aPAD
=
acute
RfD
FQPA
SF
aPAD
=
0.0034
mg/
kg/
day
Subchronic
neurotoxicity
study
in
rats.
LOAEL
=
54.6/
68.7
mg/
kg/
day
based
largely
on
hyperactivity.

Chronic
Dietary
(
all
populations)
NOAEL
=
3.4
mg/
kg/
day
UF
=
1000
Chronic
RfD
=
0.0034
mg/
kg/
day
FQPA
SF
=
1X
PAD
=
chronic
RfD
FQPA
SF
cPAD
=
0.0034
mg/
kg/
day
Subchronic
neurotoxicity
study
in
rats.
LOAEL
=
54.6/
68.7
mg/
kg/
day
based
largely
on
hyperactivity.

Incidental
Oral
Short­
Term
(
1
­
30
days)
NOAEL
=
3.4
mg/
kg/
day
UF
=
1000
Residential
MOE
=
1000
Subchronic
neurotoxicity
study
in
rats.
LOAEL
=
54.6/
68.7
mg/
kg/
day
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Table
2:
Summary
of
Toxicological
Doses
and
Endpoints
for
Triadimefon
and
Triadimenol
Exposure
Scenario
Dose
Used
in
Risk
Assessment,
UF
FQPA
SF*
and
Level
of
Concern
for
Risk
Assessment
Study
and
Toxicological
Effects
based
largely
on
hyperactivity.

Incidental
Oral
Intermediate­
Term
(
1
­
6
months)
NOAEL
=
3.4
mg/
kg/
day
UF
=
1000
Residential
MOE
=
1000
Subchronic
neurotoxicity
study
in
rats.
LOAEL
=
54.6/
68.7
mg/
kg/
day
based
largely
on
hyperactivity.

Dermal
Short­
Term
(
1
­
30
days)
Dermal
NOAEL
=
300
mg/
kg/
day
Residential
MOE
=
1000
Occupational
MOE
=
100
21
Day
Dermal
Toxicity
in
rabbits.
The
LOAEL=
1000
mg/
kg/
day
based
on
increased
reactivity
and
activity
in
the
females.

Dermal
Intermediate­
Term
(
1
­
6
months)
Dermal
NOAEL
=
300
mg/
kg/
day
Residential
MOE
=
1000
Occupational
MOE
=
100
21
Day
Dermal
Toxicity
in
rabbits.
The
LOAEL=
1000
mg/
kg/
day
based
on
increased
reactivity
and
activity
in
the
females.

Dermal
Long­
Term
(>
6
months)
Not
Applicable
Not
Applicable
Quantitative
risk
assessment
is
not
required
since
no
long­
term
dermal
exposure
is
expected.

Inhalation
Short­
Term
(
1
­
30
days)
NOAEL
=
3.4
mg/
kg/
day
(
Inhalation
absorption
rate
=
100%)
Residential
MOE
=
1000
Occupational
MOE
=
100
Subchronic
neurotoxicity
study
in
rats.
LOAEL
=
54.6/
68.7
mg/
kg/
day
based
largely
on
hyperactivity.

Inhalation
Intermediate­
Term
(
1
­
6
months)
NOAEL
=
3.4
mg/
kg/
day
(
Inhalation
absorption
rate
=
100%)
Residential
MOE
=
1000
Occupational
MOE
=
100
Subchronic
neurotoxicity
study
in
rats.
LOAEL
=
54.6/
68.7
mg/
kg/
day
based
largely
on
hyperactivity.

Inhalation
Long­
Term
(>
6
months)
Not
Applicable
Not
Applicable
Quantitative
risk
assessment
is
not
required
since
no
long­
term
exposure
is
expected.

Cancer
(
oral,
dermal,
inhalation)
Classification:
Category
C
"
possible
human
carcinogen"
based
on
statistically
significant
increase
in
thyroid
adenomas
in
male
Wistar
rats
and
statistically
significant
increases
in
hepatocellular
adenomas
in
both
sexes
of
the
NMRI
mouse.

UF
=
uncertainty
factor,
FQPA
SF
=
FQPA
safety
factor,
NOAEL
=
no
observed
adverse
effect
level,
LOAEL
=
lowest
observed
adverse
effect
level,
PAD
=
population
adjusted
dose
(
a
=
acute,
c
=
chronic)
RfD
=
reference
dose,
MOE
=
margin
of
exposure,
LOC
=
level
of
concern,
NA
=
Not
Applicable
V.
Results/
Discussion
As
stated
above,
for
acute
and
chronic
assessments,
HED
is
concerned
when
dietary
risk
exceeds
100%
of
the
PAD.
The
DEEM­
FCID
 
analyses
estimate
the
dietary
exposure
of
the
U.
S.
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population
and
various
population
subgroups.
The
acute
and
chronic
dietary
exposure
analyses
reported
in
Tables
3­
4
for
the
general
U.
S.
population,
all
infants
(
less
than
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
adults
20­
49,
adults
50+
years,
and
females
13­
49.

The
acute
aggregate
dietary
exposure
estimates
from
food
only
are
below
HED's
level
of
concern
(<
100%
aPAD)
at
the
95th
percentile
of
exposure.
The
acute
aggregate
dietary
risk
at
the
95th
percentile
of
exposure
from
food
only
is
15%
of
the
aPAD
for
the
U.
S.
population
and
32%
of
the
aPAD
for
children
1­
2
yrs,
the
most
highly
exposed
population
subgroup
(
see
Table
3).

The
acute
aggregate
dietary
exposure
estimates
from
drinking
water
only
using
the
Florida
turf
(
two
applications)
for
drinking
water
are
below
HED's
level
of
concern
(<
100%
aPAD)
at
the
95th
percentile
of
exposure.
At
the
95th
percentile
of
exposure
risks
were
estimated
to
be
24%
and
85%
of
the
aPAD
for
the
U.
S.
population
and
all
infants
(<
1
yr),
respectively
(
see
attachment
10).

The
acute
aggregate
dietary
exposure
estimates
from
food
and
drinking
water
using
Florida
turf
with
two
applications
for
drinking
water
are
below
HED's
level
of
concern
(<
100%
aPAD)
at
the
95th
percentile
of
exposure.
At
the
95th
percentile
of
exposure
risks
were
estimated
to
be
33%
and
94%
of
the
aPAD
for
the
U.
S.
population
and
all
infants
(<
1
yr),
respectively
(
see
Table
3).

Table
3.
Results
of
Aggregate
Acute
Dietary
Exposure
Analysis
for
Using
DEEM­
FCID
Food
Only
Food
+
Drinking
Water
95th
Percentile
95h
Percentile
Population
Subgroup
aPAD
(
mg/
kg/
day)
Exposure
(
mg/
kg/
day)
%
aPAD
Exposure
(
mg/
kg/
day)
%
aPAD
General
U.
S.
Population
0.0034
0.000520
15.29
0.001106
32.52
All
Infants
(<
1
year
old)
0.0034
0.000828
24.36
0.003190
93.82
Children
1­
2
years
old
0.0034
0.001083
31.86
0.001959
57.63
Children
3­
5
years
old
0.0034
0.000923
27.16
0.001765
51.92
Children
6­
12
years
old
0.0034
0.000668
19.64
0.001210
35.58
Youth
13­
19
years
old
0.0034
0.000440
12.95
0.000859
25.28
Adults
20­
49
years
old
0.0034
0.000334
9.82
0.000942
27.72
Adults
50+
years
old
0.0034
0.000249
7.33
0.000921
27.10
Females
13­
49
year
old
0.0034
0.000322
9.47
0.000936
27.52
The
chronic
aggregate
dietary
exposure
estimates
from
food
only
are
below
HED's
level
of
concern
(<
100%
cPAD)
for
the
U.
S.
population
and
all
population
subgroups.
The
chronic
aggregate
dietary
risk
from
food
only
for
the
U.
S.
population
is
6%
of
the
cPAD
and
15%
of
the
cPAD
for
children
1­
2
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of
21
yrs,
the
most
highly
exposed
population
subgroup
(
see
Table
4).

The
chronic
aggregate
dietary
exposure
estimates
from
drinking
water
only
using
the
Florida
turf
with
two
applications,
are
below
HED's
level
of
concern
(<
100%
cPAD)
for
the
U.
S.
population
and
all
population
subgroups.
The
aggregate
dietary
risk
from
drinking
water
for
the
U.
S.
population
is
12%
of
the
cPAD
and
40%
of
the
cPAD
for
all
infants
(<
1
yr),
the
most
highly
exposed
population
subgroup
(
see
Attachment
12).

The
chronic
aggregate
dietary
exposure
estimates
from
food
and
drinking
water
using
Florida
turf,
two
applications
are
below
HED's
level
of
concern
(<
100%
cPAD)
for
the
U.
S.
population
and
all
population
subgroups.
The
aggregate
dietary
risk
from
food
and
drinking
water
for
the
U.
S.
population
is
18%
of
the
cPAD
and
47%
of
the
cPAD
for
all
infants
(<
1
yr),
the
most
highly
exposed
population
subgroup
(
see
Table
4).

Table
4.
Results
of
Aggregate
Chronic
Dietary
Risk
Analysis
from
(
Food
Alone)
and
(
Food
+
Drinking
Water­
Entire
Course)
Using
DEEM­
FCID
Population
Subgroup
Food
Alone
Food
+
Drinking
Water
(
Entire
Course)
cPAD
(
mg/
kg/
day)

Exposure
(
mg/
kg/
day)
%
cPAD
Exposure
(
mg/
kg/
day)
%
cPAD
General
U.
S.
Population
0.0034
0.000194
5.7%
0.000607
17.9%

All
Infants
(<
1
year
old)
0.0034
0.000227
6.7%
0.001584
46.6%

Children
1­
2
years
old
0.0034
0.000493
14.5%
0.001108
32.6%

Children
3­
5
years
old
0.0034
0.000471
13.9%
0.001047
30.8%

Children
6­
12
years
old
0.0034
0.000323
9.5%
0.000720
21.2%

Youth
13­
19
years
old
0.0034
0.000203
6.0%
0.000503
14.8%

Adults
20­
49
years
old
0.0034
0.000154
4.5%
0.000540
15.9%

Adults
50+
years
old
0.0034
0.000117
3.4%
0.00052
15.4%

Females
13­
49
year
old
0.0034
0.000147
4.3%
0.000532
15.6%

The
short­
term
aggregate
risk
reflecting
residential
handler
scenarios:
Application
to
ornamentals
(
azaleas
=
worst
case
residential
handler
(
MOE
of
1100
for
dermal
+
inhalation).
The
resulting
shortterm
aggregate
has
a
MOE
of
920
which
exceeds
HED
level
of
concern.
Another
scenario
residential
handler
(
mixer,
loader,
applicator)
for
low­
pressure
hand­
wand
application
of
a
WP
to
green
house
ornamental
has
a
MOE
of
1700
(
dermal
+
inhalation).
The
resulting
short
 
term
aggregate
MOE
is
1300.

Short­
term
aggregate
for
toddlers
due
to
post­
application
exposure
to
treated
sod
(
i.
e.
sod
transplanted
to
a
residential
lawn).
The
MOE
(
combined
hand­
to­
mouth,
dermal
and
inhalation)
at
a
sod
pre­
harvest
interval
of
15
days
was
1100;
the
MOE
was
of
concern
(<
1000)
at
14
days.
The
chronic
dietary
(
food
+
water)
exposure
for
children
1­
2
years
is
a
MOE
of
3100.
The
resulting
short­
term
aggregate
MOE
was
810.

On
day
17,
the
combined
MOE's
for
toddlers
on
sod
treated
at
the
2.7
lb
a.
i./
A
rate
is
1700.
When
this
rate
is
aggregated
with
the
chronic
dietary
(
food
and
water)
MOE
of
3100
MOE,
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resultant
aggregate
is
1100.
The
individual
MOE's
are
as
follows:
a)
Hand­
To­
Mouth
=
2500;
b)
Object­
To­
Mouth
=
10,000;
c)
Soil
=
31,000;
Dermal
=
11,000.
The
short­
term
toddler
aggregate
on
day
16
is
920.

VI.
List
of
Attachments
Attachment
1
Acute
Aggregate
(
food
only)
Residue
Input
Data
Attachment
2
Acute
Aggregate
(
food
only)
Residue
Analysis
Attachment
3
Acute
Aggregate
(
food
+
water)
Residue
Input
Data
Attachment
4
Acute
Aggregate
(
food
+
water)
Residue
Analysis
Attachment
5
Chronic
Aggregate
(
food
only)
Residue
Input
Data
Attachment
6
Chronic
Aggregate
(
food
only)
Residue
Analysis
Attachment
7
Chronic
Aggregate
(
food
+
water)
Residue
Input
Data
Attachment
8
Chronic
Aggregate
(
food
+
water)
Residue
Analysis
Attachment
9
Acute
Aggregate
(
Water
only)
Residue
Input
Data
Attachment
10
Acute
Aggregate
(
Water
only)
Residue
Analysis
Attachment
11
Chronic
Aggregate
(
Water
only)
Residue
Input
Data
Attachment
12
Chronic
Aggregate
(
Water
only)
Residue
Analysis
Attachment
13
Short­
Term
Aggregate
Calculations
cc:
S.
Piper,
CEB
Reading
Files;
Y.
Barnes,
RRB2
Reading
Files
RDI:
08/
01/
06
William
Hazel;
Richard
Griffin
08/
01/
06;
David
Miller
08/
02/
06
7509P:
CEB
PY­
Room
10244:
308­
2717:
Triadimefon/
Triadimenol
Triadimefon
&
Triadimenol
Aggregate
Risk
Assessment
­
RED
DP
Barcode:
331455
Page
12
of
21
Attachment
1:
Acute
Aggregate
(
food
only)
Residue
Input
Data
U.
S.
Environmental
Protection
Agency
Ver.
2.02
DEEM­
FCID
Acute
analysis
for
TRIADIMEFON
Residue
file
name:
C:\
Documents
and
Settings\
spiper\
SPIPER\
triadimenol\
AggregateFoodonly_
7242006.
R98
Analysis
Date
07­
25­
2006
Residue
file
dated:
07­
25­
2006/
09:
23:
21/
8
Reference
dose
(
aRfD)
=
0.0034
mg/
kg
bw/
day
Comment:
Triadimefon
+
Triadimenol
[
food
only]
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
RDL
indices
and
parameters
for
Monte
Carlo
Analysis:
Index
Dist
Parameter
#
1
Param
#
2
Param
#
3
Comment
#
Code
­­­­­
­­­­
­­­­­­­­­­­­
­­­­­­­­­­­
­­­­­­­­­­­
­­­­­­­­­­
1
6
Apple,
NB
or
PB
6
21
2006.
rdf
2
6
Apple,
B
­
6
21
2006.
rdf
3
6
GrapesPB
6
21
2006.
rdf
4
6
Pear,
NB
or
PB
6
21
2006.
rdf
5
6
Pineapples,
FT
6
21
2006.
rdf
6
6
new
FDA
Raspberry
06
29
2006.
rdf
7
6
Banana,
PBNB­
FT
6
21
2006.
rdf
8
6
FLturf2applmaxDW_
triadimefon.
rdf
EPA
Crop
Food
Name
Def
Res
Adj.
Factors
RDL
Comment
Code
Grp
(
ppm)
#
1
#
2
Pntr
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­
­­­­­­­
95000230
O
Banana
0.030000
1.000
1.000
7
95000231
O
Banana­
babyfood
0.030000
1.000
1.000
7
95000240
O
Banana,
dried
0.030000
3.900
1.000
95000241
O
Banana,
dried­
babyfood
0.030000
3.900
1.000
15000250
15
Barley,
pearled
barley
0.050000
1.000
1.000
15000251
15
Barley,
pearled
barley­
babyfood
0.050000
1.000
1.000
15000260
15
Barley,
flour
0.050000
1.000
1.000
15000261
15
Barley,
flour­
babyfood
0.050000
1.000
1.000
15000270
15
Barley,
bran
0.050000
2.100
1.000
15001200
15
Corn,
field,
flour
0.050000
1.000
1.000
15001201
15
Corn,
field,
flour­
babyfood
0.050000
1.000
1.000
15001210
15
Corn,
field,
meal
0.050000
1.000
1.000
15001211
15
Corn,
field,
meal­
babyfood
0.050000
1.000
1.000
15001220
15
Corn,
field,
bran
0.050000
1.000
1.000
15001230
15
Corn,
field,
starch
0.050000
1.000
1.000
15001231
15
Corn,
field,
starch­
babyfood
0.050000
1.000
1.000
15001240
15
Corn,
field,
syrup
0.050000
1.000
1.000
15001241
15
Corn,
field,
syrup­
babyfood
0.050000
1.000
1.000
15001250
15
Corn,
field,
oil
0.050000
1.000
1.000
15001251
15
Corn,
field,
oil­
babyfood
0.050000
1.000
1.000
15001260
15
Corn,
pop
0.050000
1.000
1.000
15001270
15
Corn,
sweet
0.050000
1.000
1.000
15001271
15
Corn,
sweet­
babyfood
0.050000
1.000
1.000
95001280
O
Cottonseed,
oil
0.020000
1.000
1.000
95001281
O
Cottonseed,
oil­
babyfood
0.020000
1.000
1.000
15002310
15
Oat,
bran
0.050000
2.100
1.000
15002320
15
Oat,
flour
0.050000
1.000
1.000
15002321
15
Oat,
flour­
babyfood
0.050000
1.000
1.000
15002330
15
Oat,
groats/
rolled
oats
0.050000
1.000
1.000
15002331
15
Oat,
groats/
rolled
oats­
babyfood
0.050000
1.000
1.000
95002790
O
Pineapple
0.079000
1.000
1.000
5
95002791
O
Pineapple­
babyfood
0.079000
1.000
1.000
5
95002800
O
Pineapple,
dried
0.079000
1.000
1.000
5
95002810
O
Pineapple,
juice
0.079000
1.000
1.000
5
95002811
O
Pineapple,
juice­
babyfood
0.079000
1.000
1.000
5
15003280
15
Rye,
grain
0.050000
1.000
1.000
15003290
15
Rye,
flour
0.050000
1.000
1.000
15004010
15
Wheat,
grain
0.050000
1.000
1.000
15004011
15
Wheat,
grain­
babyfood
0.050000
1.000
1.000
15004020
15
Wheat,
flour
0.050000
1.000
1.000
15004021
15
Wheat,
flour­
babyfood
0.050000
1.000
1.000
15004030
15
Wheat,
germ
0.050000
1.000
1.000
15004040
15
Wheat,
bran
0.050000
2.100
1.000
Triadimefon
&
Triadimenol
Aggregate
Risk
Assessment
­
RED
DP
Barcode:
331455
Page
13
of
21
Attachment
2:
Acute
Aggregate
(
food
only)
Residue
Analysis
U.
S.
Environmental
Protection
Agency
Ver.
2.02
DEEM­
FCID
ACUTE
Analysis
for
TRIADIMEFON
(
1994­
98
data)
Residue
file:
AggregateFoodonly_
7242006.
R98
Adjustment
factor
#
2
used.
Analysis
Date:
07­
25­
2006/
09:
27:
48
Residue
file
dated:
07­
25­
2006/
09:
23:
21/
8
Daily
totals
for
food
and
foodform
consumption
used.
MC
iterations
=
1000
MC
list
in
residue
file
MC
seed
=
10
Run
Comment:
"
Triadimefon
+
Triadimenol
[
food
only]"
===============================================================================

Summary
calculations
(
per
capita):

95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
%
aRfD
Exposure
%
aRfD
Exposure
%
aRfD
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
U.
S.
Population:
0.000520
15.29
0.000855
25.14
0.001490
43.82
All
infants:
0.000828
24.36
0.001298
38.18
0.002021
59.44
Children
1­
2
yrs:
0.001083
31.86
0.001681
49.45
0.002720
80.01
Children
3­
5
yrs:
0.000923
27.16
0.001289
37.90
0.002230
65.58
Children
6­
12
yrs:
0.000668
19.64
0.000931
27.39
0.001446
42.54
Youth
13­
19
yrs:
0.000440
12.95
0.000646
19.00
0.001076
31.64
Adults
20­
49
yrs:
0.000334
9.82
0.000516
15.17
0.000865
25.43
Adults
50+
yrs:
0.000249
7.33
0.000350
10.29
0.000548
16.11
Females
13­
49
yrs:
0.000322
9.47
0.000479
14.09
0.001134
33.36
Attachment
3:
Acute
Aggregate
(
food
+
water)
Residue
Input
Data
U.
S.
Environmental
Protection
Agency
Ver.
2.02
DEEM­
FCID
Acute
analysis
for
TRIADIMEFON
Residue
file
name:
C:\
Documents
and
Settings\
spiper\
SPIPER\
triadimenol\
AggregateFLturf2app_
7242006.
R98
Analysis
Date
07­
25­
2006
Residue
file
dated:
07­
25­
2006/
10:
04:
48/
8
Reference
dose
(
aRfD)
=
0.0034
mg/
kg
bw/
day
Comment:
Triadimefon
+
Triadimenol
[
food
+
FL
turf
2
appl
max]
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
RDL
indices
and
parameters
for
Monte
Carlo
Analysis:
Index
Dist
Parameter
#
1
Param
#
2
Param
#
3
Comment
#
Code
­­­­­
­­­­
­­­­­­­­­­­­
­­­­­­­­­­­
­­­­­­­­­­­
­­­­­­­­­­
1
6
Apple,
NB
or
PB
6
21
2006.
rdf
2
6
Apple,
B
­
6
21
2006.
rdf
3
6
GrapesPB
6
21
2006.
rdf
4
6
Pear,
NB
or
PB
6
21
2006.
rdf
5
6
Pineapples,
FT
6
21
2006.
rdf
6
6
new
FDA
Raspberry
06
29
2006.
rdf
7
6
Banana,
PBNB­
FT
6
21
2006.
rdf
8
6
FLturf2applmaxDW_
triadimefon.
rdf
EPA
Crop
Food
Name
Def
Res
Adj.
Factors
RDL
Comment
Code
Grp
(
ppm)
#
1
#
2
Pntr
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­
­­­­­­­
95000230
O
Banana
0.030000
1.000
1.000
7
95000231
O
Banana­
babyfood
0.030000
1.000
1.000
7
95000240
O
Banana,
dried
0.030000
3.900
1.000
Triadimefon
&
Triadimenol
Aggregate
Risk
Assessment
­
RED
DP
Barcode:
331455
Page
14
of
21
95000241
O
Banana,
dried­
babyfood
0.030000
3.900
1.000
15000250
15
Barley,
pearled
barley
0.050000
1.000
1.000
15000251
15
Barley,
pearled
barley­
babyfood
0.050000
1.000
1.000
15000260
15
Barley,
flour
0.050000
1.000
1.000
15000261
15
Barley,
flour­
babyfood
0.050000
1.000
1.000
15000270
15
Barley,
bran
0.050000
2.100
1.000
15001200
15
Corn,
field,
flour
0.050000
1.000
1.000
15001201
15
Corn,
field,
flour­
babyfood
0.050000
1.000
1.000
15001210
15
Corn,
field,
meal
0.050000
1.000
1.000
15001211
15
Corn,
field,
meal­
babyfood
0.050000
1.000
1.000
15001220
15
Corn,
field,
bran
0.050000
1.000
1.000
15001230
15
Corn,
field,
starch
0.050000
1.000
1.000
15001231
15
Corn,
field,
starch­
babyfood
0.050000
1.000
1.000
15001240
15
Corn,
field,
syrup
0.050000
1.000
1.000
15001241
15
Corn,
field,
syrup­
babyfood
0.050000
1.000
1.000
15001250
15
Corn,
field,
oil
0.050000
1.000
1.000
15001251
15
Corn,
field,
oil­
babyfood
0.050000
1.000
1.000
15001260
15
Corn,
pop
0.050000
1.000
1.000
15001270
15
Corn,
sweet
0.050000
1.000
1.000
15001271
15
Corn,
sweet­
babyfood
0.050000
1.000
1.000
95001280
O
Cottonseed,
oil
0.020000
1.000
1.000
95001281
O
Cottonseed,
oil­
babyfood
0.020000
1.000
1.000
15002310
15
Oat,
bran
0.050000
2.100
1.000
15002320
15
Oat,
flour
0.050000
1.000
1.000
15002321
15
Oat,
flour­
babyfood
0.050000
1.000
1.000
15002330
15
Oat,
groats/
rolled
oats
0.050000
1.000
1.000
15002331
15
Oat,
groats/
rolled
oats­
babyfood
0.050000
1.000
1.000
95002790
O
Pineapple
0.100000
1.000
1.000
5
95002791
O
Pineapple­
babyfood
0.100000
1.000
1.000
5
95002800
O
Pineapple,
dried
0.100000
1.000
1.000
5
95002810
O
Pineapple,
juice
0.100000
1.000
1.000
5
95002811
O
Pineapple,
juice­
babyfood
0.100000
1.000
1.000
5
15003280
15
Rye,
grain
0.050000
1.000
1.000
15003290
15
Rye,
flour
0.050000
1.000
1.000
86010000
O
Water,
direct,
all
sources
0.010000
1.000
1.000
8
86020000
O
Water,
indirect,
all
sources
0.010000
1.000
1.000
8
15004010
15
Wheat,
grain
0.050000
1.000
1.000
15004011
15
Wheat,
grain­
babyfood
0.050000
1.000
1.000
15004020
15
Wheat,
flour
0.050000
1.000
1.000
15004021
15
Wheat,
flour­
babyfood
0.050000
1.000
1.000
15004030
15
Wheat,
germ
0.050000
1.000
1.000
15004040
15
Wheat,
bran
0.050000
2.100
1.000
Attachment
4:
Acute
Aggregate
(
food
+
water)
Residue
Analysis
U.
S.
Environmental
Protection
Agency
Ver.
2.02
DEEM­
FCID
ACUTE
Analysis
for
TRIADIMEFON
(
1994­
98
data)
Residue
file:
AggregateFLturf2app_
7242006.
R98
Adjustment
factor
#
2
used.
Analysis
Date:
07­
25­
2006/
10:
09:
57
Residue
file
dated:
07­
25­
2006/
10:
04:
48/
8
Daily
totals
for
food
and
foodform
consumption
used.
MC
iterations
=
1000
MC
list
in
residue
file
MC
seed
=
10
Run
Comment:
"
Triadimefon
+
Triadimenol
[
food
+
FL
turf
2
appl
max]"
===============================================================================

Summary
calculations
(
per
capita):

95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
%
aRfD
Exposure
%
aRfD
Exposure
%
aRfD
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
U.
S.
Population:
0.001106
32.52
0.002350
69.11
0.005541
162.98
All
infants:
0.003190
93.82
0.007747
227.87
0.017654
519.24
Children
1­
2
yrs:
0.001959
57.63
0.003817
112.26
0.008347
245.51
Children
3­
5
yrs:
0.001765
51.92
0.003482
102.42
0.007469
219.69
Children
6­
12
yrs:
Triadimefon
&
Triadimenol
Aggregate
Risk
Assessment
­
RED
DP
Barcode:
331455
Page
15
of
21
0.001210
35.58
0.002400
70.58
0.005175
152.20
Youth
13­
19
yrs:
0.000859
25.28
0.001802
53.00
0.004235
124.57
Adults
20­
49
yrs:
0.000942
27.72
0.002085
61.33
0.004808
141.40
Adults
50+
yrs:
0.000921
27.10
0.001982
58.29
0.004131
121.50
Females
13­
49
yrs:
0.000936
27.52
0.002087
61.39
0.004779
140.55
Attachment
5:
Chronic
Aggregate
(
food
only)
Residue
Input
Data
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
TRIADIMEFON
1994­
98
data
Residue
file:
C:\
Documents
and
Settings\
spiper\
SPIPER\
triadimenol\
aggregatelFoodonly_
chronic7242006.
R98
Adjust.
#
2
used
Analysis
Date
07­
25­
2006
Residue
file
dated:
07­
25­
2006/
09:
36:
52/
8
Reference
dose
(
RfD)
=
0.0034
mg/
kg
bw/
day
Comment:
Chronic:
Triadimefon
+
Triadimenol
food
only
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Food
Crop
Residue
Adj.
Factors
Comment
EPA
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
95000230
O
Banana
0.030000
1.000
1.000
95000231
O
Banana­
babyfood
0.030000
1.000
1.000
95000240
O
Banana,
dried
0.030000
3.900
1.000
95000241
O
Banana,
dried­
babyfood
0.030000
3.900
1.000
15000250
15
Barley,
pearled
barley
0.050000
1.000
1.000
15000251
15
Barley,
pearled
barley­
babyfood
0.050000
1.000
1.000
15000260
15
Barley,
flour
0.050000
1.000
1.000
15000261
15
Barley,
flour­
babyfood
0.050000
1.000
1.000
15000270
15
Barley,
bran
0.050000
2.100
1.000
15001200
15
Corn,
field,
flour
0.050000
1.000
1.000
15001201
15
Corn,
field,
flour­
babyfood
0.050000
1.000
1.000
15001210
15
Corn,
field,
meal
0.050000
1.000
1.000
15001211
15
Corn,
field,
meal­
babyfood
0.050000
1.000
1.000
15001220
15
Corn,
field,
bran
0.050000
1.000
1.000
15001230
15
Corn,
field,
starch
0.050000
1.000
1.000
15001231
15
Corn,
field,
starch­
babyfood
0.050000
1.000
1.000
15001240
15
Corn,
field,
syrup
0.050000
1.000
1.000
15001241
15
Corn,
field,
syrup­
babyfood
0.050000
1.000
1.000
15001250
15
Corn,
field,
oil
0.050000
1.000
1.000
15001251
15
Corn,
field,
oil­
babyfood
0.050000
1.000
1.000
15001260
15
Corn,
pop
0.050000
1.000
1.000
15001270
15
Corn,
sweet
0.050000
1.000
1.000
15001271
15
Corn,
sweet­
babyfood
0.050000
1.000
1.000
95001280
O
Cottonseed,
oil
0.020000
1.000
1.000
95001281
O
Cottonseed,
oil­
babyfood
0.020000
1.000
1.000
15002310
15
Oat,
bran
0.050000
2.100
1.000
15002320
15
Oat,
flour
0.050000
1.000
1.000
15002321
15
Oat,
flour­
babyfood
0.050000
1.000
1.000
15002330
15
Oat,
groats/
rolled
oats
0.050000
1.000
1.000
15002331
15
Oat,
groats/
rolled
oats­
babyfood
0.050000
1.000
1.000
95002790
O
Pineapple
0.079000
1.000
1.000
95002791
O
Pineapple­
babyfood
0.079000
1.000
1.000
95002800
O
Pineapple,
dried
0.079000
5.000
1.000
95002810
O
Pineapple,
juice
0.079000
1.000
1.000
95002811
O
Pineapple,
juice­
babyfood
0.079000
1.000
1.000
15003280
15
Rye,
grain
0.050000
1.000
1.000
15003290
15
Rye,
flour
0.050000
1.000
1.000
15004010
15
Wheat,
grain
0.050000
1.000
1.000
15004011
15
Wheat,
grain­
babyfood
0.050000
1.000
1.000
15004020
15
Wheat,
flour
0.050000
1.000
1.000
15004021
15
Wheat,
flour­
babyfood
0.050000
1.000
1.000
15004030
15
Wheat,
germ
0.050000
1.000
1.000
15004040
15
Wheat,
bran
0.050000
2.100
1.000
Triadimefon
&
Triadimenol
Aggregate
Risk
Assessment
­
RED
DP
Barcode:
331455
Page
16
of
21
Attachment
6:
Chronic
Aggregate
(
food
only)
Residue
Analysis
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
TRIADIMEFON
(
1994­
98
data)
Residue
file
name:
C:\
Documents
and
Settings\
spiper\
SPIPER\
triadimenol\
aggregatelFoodonly_
chronic7242006.
R98
Adjustment
factor
#
2
used.
Analysis
Date
07­
25­
2006/
09:
37:
36
Residue
file
dated:
07­
25­
2006/
09:
36:
52/
8
Reference
dose
(
RfD,
Chronic)
=
.0034
mg/
kg
bw/
day
COMMENT
1:
Chronic:
Triadimefon
+
Triadimenol
food
only
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.000194
5.7%

U.
S.
Population
(
spring
season)
0.000196
5.8%
U.
S.
Population
(
summer
season)
0.000196
5.8%
U.
S.
Population
(
autumn
season)
0.000190
5.6%
U.
S.
Population
(
winter
season)
0.000192
5.6%

Northeast
region
0.000190
5.6%
Midwest
region
0.000206
6.1%
Southern
region
0.000185
5.4%
Western
region
0.000197
5.8%

Hispanics
0.000203
6.0%
Non­
hispanic
whites
0.000193
5.7%
Non­
hispanic
blacks
0.000194
5.7%
Non­
hisp/
non­
white/
non­
black
0.000178
5.2%

All
infants
(<
1
year)
0.000227
6.7%
Nursing
infants
0.000108
3.2%
Non­
nursing
infants
0.000272
8.0%
Children
1­
6
yrs
0.000467
13.7%
Children
7­
12
yrs
0.000309
9.1%

Females
13­
19
(
not
preg
or
nursing)
0.000177
5.2%
Females
20+
(
not
preg
or
nursing)
0.000128
3.8%
Females
13­
50
yrs
0.000157
4.6%
Females
13+
(
preg/
not
nursing)
0.000155
4.6%
Females
13+
(
nursing)
0.000175
5.2%

Males
13­
19
yrs
0.000229
6.7%
Males
20+
yrs
0.000153
4.5%
Seniors
55+
0.000115
3.4%

Children
1­
2
yrs
0.000493
14.5%
Children
3­
5
yrs
0.000471
13.9%
Children
6­
12
yrs
0.000323
9.5%
Youth
13­
19
yrs
0.000203
6.0%
Adults
20­
49
yrs
0.000154
4.5%
Adults
50+
yrs
0.000117
3.4%
Females
13­
49
yrs
0.000147
4.3%

­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Attachment
7:
Chronic
Aggregate
(
food
+
water)
Residue
Input
Data
Triadimefon
&
Triadimenol
Aggregate
Risk
Assessment
­
RED
DP
Barcode:
331455
Page
17
of
21
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
TRIADIMEFON
1994­
98
data
Residue
file:
C:\
Documents
and
Settings\
spiper\
SPIPER\
triadimenol\
aggregatelFLturf2app_
chronic7242006.
R98
Adjust.
#
2
used
Analysis
Date
07­
25­
2006
Residue
file
dated:
07­
25­
2006/
10:
14:
45/
8
Reference
dose
(
RfD)
=
0.0034
mg/
kg
bw/
day
Comment:
Chronic:
Triadimefon
+
Triadimenol
food
and
drinking
water[
FL
turf
2
appl
max]
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Food
Crop
Residue
Adj.
Factors
Comment
EPA
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
95000230
O
Banana
0.030000
1.000
1.000
95000231
O
Banana­
babyfood
0.030000
1.000
1.000
95000240
O
Banana,
dried
0.030000
3.900
1.000
95000241
O
Banana,
dried­
babyfood
0.030000
3.900
1.000
15000250
15
Barley,
pearled
barley
0.050000
1.000
1.000
15000251
15
Barley,
pearled
barley­
babyfood
0.050000
1.000
1.000
15000260
15
Barley,
flour
0.050000
1.000
1.000
15000261
15
Barley,
flour­
babyfood
0.050000
1.000
1.000
15000270
15
Barley,
bran
0.050000
2.100
1.000
15001200
15
Corn,
field,
flour
0.050000
1.000
1.000
15001201
15
Corn,
field,
flour­
babyfood
0.050000
1.000
1.000
15001210
15
Corn,
field,
meal
0.050000
1.000
1.000
15001211
15
Corn,
field,
meal­
babyfood
0.050000
1.000
1.000
15001220
15
Corn,
field,
bran
0.050000
1.000
1.000
15001230
15
Corn,
field,
starch
0.050000
1.000
1.000
15001231
15
Corn,
field,
starch­
babyfood
0.050000
1.000
1.000
15001240
15
Corn,
field,
syrup
0.050000
1.000
1.000
15001241
15
Corn,
field,
syrup­
babyfood
0.050000
1.000
1.000
15001250
15
Corn,
field,
oil
0.050000
1.000
1.000
15001251
15
Corn,
field,
oil­
babyfood
0.050000
1.000
1.000
15001260
15
Corn,
pop
0.050000
1.000
1.000
15001270
15
Corn,
sweet
0.050000
1.000
1.000
15001271
15
Corn,
sweet­
babyfood
0.050000
1.000
1.000
95001280
O
Cottonseed,
oil
0.020000
1.000
1.000
95001281
O
Cottonseed,
oil­
babyfood
0.020000
1.000
1.000
15002310
15
Oat,
bran
0.050000
2.100
1.000
15002320
15
Oat,
flour
0.050000
1.000
1.000
15002321
15
Oat,
flour­
babyfood
0.050000
1.000
1.000
15002330
15
Oat,
groats/
rolled
oats
0.050000
1.000
1.000
15002331
15
Oat,
groats/
rolled
oats­
babyfood
0.050000
1.000
1.000
95002790
O
Pineapple
0.079000
1.000
1.000
95002791
O
Pineapple­
babyfood
0.079000
1.000
1.000
95002800
O
Pineapple,
dried
0.079000
5.000
1.000
95002810
O
Pineapple,
juice
0.079000
1.000
1.000
95002811
O
Pineapple,
juice­
babyfood
0.079000
1.000
1.000
15003280
15
Rye,
grain
0.050000
1.000
1.000
15003290
15
Rye,
flour
0.050000
1.000
1.000
86010000
O
Water,
direct,
all
sources
0.019633
1.000
1.000
86020000
O
Water,
indirect,
all
sources
0.019633
1.000
1.000
15004010
15
Wheat,
grain
0.050000
1.000
1.000
15004011
15
Wheat,
grain­
babyfood
0.050000
1.000
1.000
15004020
15
Wheat,
flour
0.050000
1.000
1.000
15004021
15
Wheat,
flour­
babyfood
0.050000
1.000
1.000
15004030
15
Wheat,
germ
0.050000
1.000
1.000
15004040
15
Wheat,
bran
0.050000
2.100
1.000
Attachment
8:
Chronic
Aggregate
(
food
+
water)
Residue
Analysis
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
TRIADIMEFON
1994­
98
data
Residue
file:
C:\
Documents
and
Settings\
spiper\
SPIPER\
triadimenol\
aggregatelFLturf2app_
chronic7242006.
R98
Adjust.
#
2
used
Analysis
Date
07­
25­
2006
Residue
file
dated:
07­
25­
2006/
10:
14:
45/
8
Reference
dose
(
RfD)
=
0.0034
mg/
kg
bw/
day
Triadimefon
&
Triadimenol
Aggregate
Risk
Assessment
­
RED
DP
Barcode:
331455
Page
18
of
21
Comment:
Chronic:
Triadimefon
+
Triadimenol
food
and
drinking
water[
FL
turf
2
appl
max]
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Food
Crop
Residue
Adj.
Factors
Comment
EPA
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
95000230
O
Banana
0.030000
1.000
1.000
95000231
O
Banana­
babyfood
0.030000
1.000
1.000
95000240
O
Banana,
dried
0.030000
3.900
1.000
95000241
O
Banana,
dried­
babyfood
0.030000
3.900
1.000
15000250
15
Barley,
pearled
barley
0.050000
1.000
1.000
15000251
15
Barley,
pearled
barley­
babyfood
0.050000
1.000
1.000
15000260
15
Barley,
flour
0.050000
1.000
1.000
15000261
15
Barley,
flour­
babyfood
0.050000
1.000
1.000
15000270
15
Barley,
bran
0.050000
2.100
1.000
15001200
15
Corn,
field,
flour
0.050000
1.000
1.000
15001201
15
Corn,
field,
flour­
babyfood
0.050000
1.000
1.000
15001210
15
Corn,
field,
meal
0.050000
1.000
1.000
15001211
15
Corn,
field,
meal­
babyfood
0.050000
1.000
1.000
15001220
15
Corn,
field,
bran
0.050000
1.000
1.000
15001230
15
Corn,
field,
starch
0.050000
1.000
1.000
15001231
15
Corn,
field,
starch­
babyfood
0.050000
1.000
1.000
15001240
15
Corn,
field,
syrup
0.050000
1.000
1.000
15001241
15
Corn,
field,
syrup­
babyfood
0.050000
1.000
1.000
15001250
15
Corn,
field,
oil
0.050000
1.000
1.000
15001251
15
Corn,
field,
oil­
babyfood
0.050000
1.000
1.000
15001260
15
Corn,
pop
0.050000
1.000
1.000
15001270
15
Corn,
sweet
0.050000
1.000
1.000
15001271
15
Corn,
sweet­
babyfood
0.050000
1.000
1.000
95001280
O
Cottonseed,
oil
0.020000
1.000
1.000
95001281
O
Cottonseed,
oil­
babyfood
0.020000
1.000
1.000
15002310
15
Oat,
bran
0.050000
2.100
1.000
15002320
15
Oat,
flour
0.050000
1.000
1.000
15002321
15
Oat,
flour­
babyfood
0.050000
1.000
1.000
15002330
15
Oat,
groats/
rolled
oats
0.050000
1.000
1.000
15002331
15
Oat,
groats/
rolled
oats­
babyfood
0.050000
1.000
1.000
95002790
O
Pineapple
0.079000
1.000
1.000
95002791
O
Pineapple­
babyfood
0.079000
1.000
1.000
95002800
O
Pineapple,
dried
0.079000
5.000
1.000
95002810
O
Pineapple,
juice
0.079000
1.000
1.000
95002811
O
Pineapple,
juice­
babyfood
0.079000
1.000
1.000
15003280
15
Rye,
grain
0.050000
1.000
1.000
15003290
15
Rye,
flour
0.050000
1.000
1.000
86010000
O
Water,
direct,
all
sources
0.019633
1.000
1.000
86020000
O
Water,
indirect,
all
sources
0.019633
1.000
1.000
15004010
15
Wheat,
grain
0.050000
1.000
1.000
15004011
15
Wheat,
grain­
babyfood
0.050000
1.000
1.000
15004020
15
Wheat,
flour
0.050000
1.000
1.000
15004021
15
Wheat,
flour­
babyfood
0.050000
1.000
1.000
15004030
15
Wheat,
germ
0.050000
1.000
1.000
15004040
15
Wheat,
bran
0.050000
2.100
1.000
Attachment
9
Acute
Aggregate
(
Water
only)
Residue
Input
Data
U.
S.
Environmental
Protection
Agency
Ver.
2.02
DEEM­
FCID
Acute
analysis
for
TRIADIMEFON
Residue
file
name:
C:\
Documents
and
Settings\
spiper\
SPIPER\
triadimenol\
AggregateWateronly_
7242006.
R98
Analysis
Date
07­
25­
2006
Residue
file
dated:
07­
25­
2006/
09:
41:
04/
8
Reference
dose
(
aRfD)
=
0.0034
mg/
kg
bw/
day
Comment:
Triadimefon
+
Triadimenol
[
drinking
water
only]
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
RDL
indices
and
parameters
for
Monte
Carlo
Analysis:
Index
Dist
Parameter
#
1
Param
#
2
Param
#
3
Comment
#
Code
­­­­­
­­­­
­­­­­­­­­­­­
­­­­­­­­­­­
­­­­­­­­­­­
­­­­­­­­­­
1
6
Apple,
NB
or
PB
6
21
2006.
rdf
2
6
Apple,
B
­
6
21
2006.
rdf
Triadimefon
&
Triadimenol
Aggregate
Risk
Assessment
­
RED
DP
Barcode:
331455
Page
19
of
21
3
6
GrapesPB
6
21
2006.
rdf
4
6
Pear,
NB
or
PB
6
21
2006.
rdf
5
6
Pineapples,
FT
6
21
2006.
rdf
6
6
new
FDA
Raspberry
06
29
2006.
rdf
7
6
Banana,
PBNB­
FT
6
21
2006.
rdf
8
6
FLturf2applmaxDW_
triadimefon.
rdf
EPA
Crop
Food
Name
Def
Res
Adj.
Factors
RDL
Comment
Code
Grp
(
ppm)
#
1
#
2
Pntr
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­
­­­­­­­
86010000
O
Water,
direct,
all
sources
0.100000
1.000
1.000
8
86020000
O
Water,
indirect,
all
sources
0.100000
1.000
1.000
8
Attachment
10
Acute
Aggregate
(
Water
only)
Residue
Analysis
U.
S.
Environmental
Protection
Agency
Ver.
2.02
DEEM­
FCID
ACUTE
Analysis
for
TRIADIMEFON
(
1994­
98
data)
Residue
file:
AggregateWateronly_
7242006.
R98
Adjustment
factor
#
2
used.
Analysis
Date:
07­
25­
2006/
09:
45:
07
Residue
file
dated:
07­
25­
2006/
09:
41:
04/
8
Daily
totals
for
food
and
foodform
consumption
used.
MC
iterations
=
1000
MC
list
in
residue
file
MC
seed
=
10
Run
Comment:
"
Triadimefon
+
Triadimenol
[
drinking
water
only]
"
===============================================================================

Summary
calculations
(
per
capita):

95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
%
aRfD
Exposure
%
aRfD
Exposure
%
aRfD
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
U.
S.
Population:
0.000812
23.87
0.002064
60.70
0.005235
153.96
All
infants:
0.002904
85.42
0.007494
220.43
0.017596
517.54
Children
1­
2
yrs:
0.001235
36.31
0.003156
92.83
0.007657
225.20
Children
3­
5
yrs:
0.001148
33.76
0.002896
85.17
0.006935
203.96
Children
6­
12
yrs:
0.000789
23.21
0.001990
58.52
0.004794
141.01
Youth
13­
19
yrs:
0.000602
17.69
0.001582
46.54
0.004005
117.80
Adults
20­
49
yrs:
0.000763
22.43
0.001908
56.12
0.004574
134.54
Adults
50+
yrs:
0.000789
23.21
0.001857
54.62
0.003999
117.61
Females
13­
49
yrs:
0.000764
22.47
0.001921
56.51
0.004562
134.18
Attachment
11
Chronic
Aggregate
(
Water
only)
Residue
Input
Data
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
TRIADIMEFON
1994­
98
data
Residue
file:
C:\
Documents
and
Settings\
spiper\
SPIPER\
triadimenol\
AggregateWateronly_
7242006chronic.
R98
Adjust.
#
2
used
Analysis
Date
07­
25­
2006
Residue
file
dated:
07­
25­
2006/
09:
52:
02/
8
Reference
dose
(
RfD)
=
0.0034
mg/
kg
bw/
day
Comment:
Chronic:
Triadimefon
+
Triadimenol
[
drinking
water
only]
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Food
Crop
Residue
Adj.
Factors
Comment
EPA
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
86010000
O
Water,
direct,
all
sources
0.019633
1.000
1.000
86020000
O
Water,
indirect,
all
sources
0.019633
1.000
1.000
Triadimefon
&
Triadimenol
Aggregate
Risk
Assessment
­
RED
DP
Barcode:
331455
Page
20
of
21
Attachment
12
Chronic
Aggregate
(
Water
only)
Residue
Analysis
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
TRIADIMEFON
(
1994­
98
data)
Residue
file
name:
C:\
Documents
and
Settings\
spiper\
SPIPER\
triadimenol\
AggregateWateronly_
7242006chronic.
R98
Adjustment
factor
#
2
used.
Analysis
Date
07­
25­
2006/
09:
52:
41
Residue
file
dated:
07­
25­
2006/
09:
52:
02/
8
Reference
dose
(
RfD,
Chronic)
=
.0034
mg/
kg
bw/
day
COMMENT
1:
Chronic:
Triadimefon
+
Triadimenol
[
drinking
water
only]
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.000414
12.2%

U.
S.
Population
(
spring
season)
0.000410
12.1%
U.
S.
Population
(
summer
season)
0.000445
13.1%
U.
S.
Population
(
autumn
season)
0.000400
11.8%
U.
S.
Population
(
winter
season)
0.000400
11.8%

Northeast
region
0.000377
11.1%
Midwest
region
0.000418
12.3%
Southern
region
0.000393
11.6%
Western
region
0.000474
13.9%

Hispanics
0.000470
13.8%
Non­
hispanic
whites
0.000404
11.9%
Non­
hispanic
blacks
0.000393
11.6%
Non­
hisp/
non­
white/
non­
black
0.000507
14.9%

All
infants
(<
1
year)
0.001357
39.9%
Nursing
infants
0.000503
14.8%
Non­
nursing
infants
0.001681
49.4%
Children
1­
6
yrs
0.000578
17.0%
Children
7­
12
yrs
0.000376
11.1%

Females
13­
19
(
not
preg
or
nursing)
0.000291
8.6%
Females
20+
(
not
preg
or
nursing)
0.000413
12.1%
Females
13­
50
yrs
0.000400
11.8%
Females
13+
(
preg/
not
nursing)
0.000402
11.8%
Females
13+
(
nursing)
0.000573
16.9%

Males
13­
19
yrs
0.000304
9.0%
Males
20+
yrs
0.000371
10.9%
Seniors
55+
0.000406
11.9%

Children
1­
2
yrs
0.000615
18.1%
Children
3­
5
yrs
0.000575
16.9%
Children
6­
12
yrs
0.000397
11.7%
Youth
13­
19
yrs
0.000299
8.8%
Adults
20­
49
yrs
0.000386
11.4%
Adults
50+
yrs
0.000406
12.0%
Females
13­
49
yrs
0.000385
11.3%

­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Attachment
13:
Short­
term
Aggregate
Calculations
Triadimefon
&
Triadimenol
Aggregate
Risk
Assessment
­
RED
DP
Barcode:
331455
Page
21
of
21
Short
Term
Aggregate
Calculations:
short­
term
aggregate
for
the
"
residential
M/
L/
A
WP
hose­
end
azalea"
scenario
which
has
an
MOE
of
1100
(
dermal+
inhalation)
is
calculated
using
the
chronic
dietary
aggregate
(
food
+
water)
with
an
exposure
number
for
the
U.
S.
general
population
=
0.000607
mg/
kg/
day
or
an
MOE
=
5600.
The
resulting
short
term
aggregate
has
an
MOE
of
920.
The
"
residential
M/
L/
A
WP
low­
P
hand­
wand
GH
ornamentals"
with
a
dermal+
inhalation
MOE
of
1700
plus
the
chronic
food
+
water
number
noted
above.
The
resulting
short
term
aggregate
has
an
MOE
of
1300.

Short
term
aggregate
(
toddler)
using
post­
application
exposure
to
sod
turf
scenarios:
the
MOE
(
combined)
at
a
sod
preharvest
interval
of
15
days
was
1100;
MOE
was
<
1000
at
14
days.
Calculation:
using
the
1100
MOE
and
the
chronic
dietary
(
food
+
water)
exposure
for
"
Children
1­
2
yrs"
which
had
an
exposure
number
of
0.001108
mg/
kg/
day
or
an
MOE
of
3100.
This
dietary
assessment
subgroup
is
the
best
match
with
toddlers
as
well
as
being
protective
of
other
children's
population
subgroups
capable
of
"
toddling."
The
resulting
short
term
aggregate
has
an
MOE
was
810.

The
calculated
number
of
days
necessary
to
result
in
a
short
term
aggregate
has
an
MOE
of
 

1000.
On
day
17,
the
combined
MOE's
for
toddlers
on
turf
at
the
rate
of
2.7
lb
a.
i.
/
A
rate
is
1700.
When
that
is
aggregated
with
the
3100
MOE,
the
aggregate
is
1100.

The
individual
MOE's
are:
a)
Hand­
To­
Mouth
=
2500;
b)
Object­
To­
Mouth
=
10,000;
c)
Soil
=
31,000;
Dermal
=
11,000
Day
16
does
not
pass
­­
it
is
920
with
the
total
aggregate.