Document ID: EPA-HQ-OPP-2013-0296-0265
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2021-03-10T05:00Z

Notes
                               October 23, 2019
                         Captan Task Force/EPA Meeting
                              Potomac Yards South
                                9:30 -11:00 am
                                Room PYS-10100
                                       
Meeting Goals: 
 To discuss the comments on EPA's preliminary human health risk assessment submitted by the Captan Task Force (CTF) to the captan registration review docket.  
 To discuss supplemental data submitted by the CTF to inform the risk assessment.
Notes:  
 Members of the Captan Task Force (ADAMA and UPL), consultants from Exponent, and EPA staff from the Health Effects Division, the Pesticide Re-evaluation Division, and the Office of Pesticide Programs front office met in person and via phone at the EPA Office of Pesticide Programs offices in Arlington, VA. A list of participants is attached.  
 Meeting participants discussed (1) comments the CTF submitted to the captan registration review docket, including two white papers and several supporting literature studies, (2) subsequent submissions of supplemental data and a white paper, and (3) EPA's questions about the comments and submissions. 
 Submitted studies included research involving human subjects conducted by the University of Montreal. Because the studies involved deliberate human exposure to captan, meeting participants discussed the regulatory criteria for use of data involving deliberate human exposure (see 26 CFR subpart M), the required information on the ethical conduct of such studies, the process of EPA's review of human research studies, and the role of the agency's Human Studies Review Board, or HSRB. 
 The submissions included a human toxicokinetic model for captan Meeting participants discussed additional information needed by EPA for the agency to evaluate and validate the toxicokinetic model. 
 Meeting participants discussed comments submitted specific to the dermal absorption of captan and possible ways to refine the dermal absorption value used in the risk assessment. 
 Meeting participants discussed supplemental dislodgeable foliar residue (DFR) dissipation data submitted to refine the re-entry assessment for captan. 
 Meeting participants also discussed an inhalation white paper submitted to EPA in the summer of 2019. 
 EPA is currently reviewing the data submissions. The agency identified barriers to use of some of the submitted data for the CTF and information and actions needed to overcome the barriers.