Document ID: EPA-HQ-OPP-2012-0980-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2013-12-20T05:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460      

OFFICE OF CHEMICAL SAFETY

                                                                        
                     AND POLLUTION PREVENTION

	

	

  SEQ CHAPTER \h \r 1 MEMORANDUM

Date:  Aug 27, 2013

SUBJECT:  Mandipropamid:  Chronic Aggregate Dietary (Food and Drinking
Water) Exposure and Risk Assessment for the Section 3 Registration
Action on Fresh Basil, Dried Basil, Ginseng, Fruiting Vegetable (Crop
Group 8-10); Small Fruit, Vine Climbing (Crop Subgroup 13-07F), except
Fuzzy Kiwifruit; Snap Bean, Bulb Onion (Crop Subgroup 3-07A), and Green
Onion (Crop Subgroup 3-07B).

PC Code:  036602	DP Number:  412238    

Decision No.:  472747	Registration No.:   100-1254

Petition No.:  2E8126	Regulatory Action:  Section 3

Risk Assessment Type:  Dietary 	Case No.:   7058

TXR No.:  None	CAS No.:  374726-62-2

MRID No.:   None	40 CFR:  §180.637

FROM:  	Dennis McNeilly, Chemist

	Registration Action Branch 2

	Health Effects Division (7509P)  SEQ CHAPTER \h \r 1 		

		

THROUGH:	Sheila Piper, Chemist

		Jennifer Tyler, Chemist

Michael Doherty, Ph.D., Senior Scientist

	Registration Action Branch 2

Health Effects Division (7509P)  SEQ CHATER \h \r 1 	

		

TO:		Laura Nollen/Barbara Madden, RM 05

Risk Integration, Minor Use, Emergency Response Branch

		Registration Division (7505P)

Executive Summary

A chronic dietary [food and drinking water] exposure and risk assessment
was conducted using the Dietary Exposure Evaluation Model software with
the Food Commodity Intake Database (DEEM-FCID) Version 3.16.  This
software uses 2003-2008 food consumption data from the U.S. Department
of Agriculture’s National Health and Nutrition Examination Survey,
What We Eat in America, (NHANES/WWEIA).  The analysis was performed to
evaluate a Section 3 request for the establishment of tolerances for
residues of mandipropamid in/on fresh basil, dried basil, ginseng,
fruiting vegetable (crop group 8-10); small fruit, vine climbing (crop
subgroup 13-07F), except fuzzy kiwifruit; snap bean, bulb onion (crop
subgroup 3-07A), and green onion (crop subgroup 3-07B).  This memorandum
was reviewed by two peer reviewers of the DESAC, per DESAC SOP 2012.1.

No acute dietary toxicity endpoint could be identified based on the
toxicology data currently available for mandipropamid; therefore, no
acute dietary exposure assessment for mandipropamid was conducted.  The
Cancer Assessment Review Committee (CARC) classified mandipropamid as
“Not likely to be a human carcinogen;” therefore a cancer assessment
was not performed.

Chronic Dietary (Food + Drinking Water) Exposure Results and
Characterization

A chronic dietary exposure assessment was performed for mandipropamid. 
The assumptions underlying this unrefined assessment were 100% crop
treated (CT), HED-recommended tolerance levels or tolerance level
residues (with the exception of vegetable, tuberous and corm, crop
subgroup 1C (which includes the SYN 500003 metabolite)), and default
DEEM-FCID( (ver. 7.81) processing factors (with the exception of
chemical-specific empirical processing factors (PF) described in Table
1).  The mean (i.e., relevant to chronic exposure) drinking water
estimate of 79 ppb was provided by the Environmental Fate and Effects
Division (EFED) and directly incorporated into the chronic assessment. 
The estimated drinking water concentration (EDWC) of 79 µg/L reflects
ground water exposure, and was used for chronic exposure.

For the general U.S. population, the exposure from food and drinking
water utilizes 27% of the chronic population adjusted dose (cPAD).  The
chronic dietary risk estimate for the most highly exposed population
subgroup, children 1-2 years old, is 46% of the cPAD.  The chronic
dietary risk assessment shows that for all included commodities, the
chronic dietary risk estimates are below the Agency’s level of concern
(i.e. <100% cPAD).

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population-adjusted dose
(PAD).  The PAD is equivalent to the point of departure (e.g., NOAEL,
LOAEL) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  References that discuss
the acute and chronic risk assessments in more detail are available on
the EPA/pesticides website:  “Available Information on Assessing
Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link:     
HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see
SOP 99.6 (8/20/1999).

The most recent dietary risk assessment for mandipropamid was conducted
(D376967, R. Chesser, 27-APR-2010) for a Section 18 Emergency Exemption
request for use on fresh and dried basil.

II.	Residue Information

Tolerances:  Permanent tolerances for residues of mandipropamid are
listed in 40 CFR §180.637 and are expressed in terms of mandipropamid
[4-chloro-N-[2-[3-methoxy-4-(2-propynyloxy)phenyl]ethyl]-
α-(2-propynyloxy)-benzeneacetamide] in/on a variety of raw agricultural
commodities (RACs), ranging from 0.01 ppm to 50 ppm. 

Residue Data used for the Chronic Dietary Assessment:

Residues of Concern (residues included in dietary exposure analysis): 
Tolerances are for the parent only, but for exposure/risk assessment
purposes the metabolite SYN 500003 has been included for the vegetable,
tuberous and corm, subgroup 1C (Residue chemistry memoranda D333121 &
D328534; D. McNeilly; 28-Aug-2007).  For drinking water, the parent plus
the metabolites SYN 500003 and SYN 504851 are included in the
exposure/risk assessment.  

Current Tolerances:  The chronic dietary risk assessment was based on
the assumption of tolerance-level residues for all commodities with
existing tolerances except for vegetable, tuberous and corm, subgroup
1C, which was assessed at 0.026 ppm (DP Num 333121 & 328534; D.
McNeilly; 28-Aug-2007), which includes the metabolites discussed for
subgroup 1C.

Recommended Tolerance:  The chronic dietary risk assessment was based on
the assumption of the following HED-recommended tolerance-level residues
for the proposed new uses (D409363, W. Drew, Aug 27, 2013).

Commodity        	   HED-Recommended

        Tolerance  (ppm)                               

Basil, fresh                                     	30

Basil, dried                                   	200

Ginseng   	0.30

Bean, Snap	0.90

Vegetable, fruiting, group 8-10    	1.0

Fruit, small, vine climbing,

subgroup 13-07F, except fuzzy kiwifruit

(Note:  Grape, raisin remains at 3.0 ppm,)	2.0

Onion, bulb, subgroup 3-07A  	0.10

Onion, green, subgroup 3-07B	7.0

Percent Crop Treated:  100 % crop treated was assumed for all
commodities.

Processing Factors:  The chemical-specific empirical processing factors
in Table 1 have been used in this assessment.  Otherwise DEEM-FCID(
(ver. 7.81) default processing factors are assumed.

Table 1.  Mandipropamid Processing Factors.

Commodity	Processing Factors  (ppm)

Grape

	       Raisin	Not used, raisin tolerance value was used

       Wine/Sherry	1.5  (empirical value)

III.   Percent Crop Treated Information

The chronic assessments are based on 100% crop treated assumptions for
all commodities.

IV.   Drinking Water Data

Drinking Water Exposure Assessment for Proposed Section 3 New Uses on:
Basil, Ginseng and Succulent Beans; and Expanded Uses on Bulb
Vegetables, Cucurbits, Grapes, and Fruiting Vegetables including
Tomatoes., D409108, R. Shamblen, 7/9/2013.

EFED conducted a Tier 1 drinking water exposure assessment for the
fungicide mandipropamid.  PRZM-GW was used to estimate mandipropamid
exposure in ground water. Maximum estimated drinking water
concentrations (EDWCs) in ground water are 87 and 79 µg/L for acute and
chronic exposures, respectively. These values are as much as 480 times
higher than SCI-GROW model results. Maximum acute and chronic EDWCs in
surface waters are 79 and 9.0 µg/L, respectively.

Previous exposure assessments evaluated maximum single application rates
of 0.13 lbs a.i./A, four times per season.  The registrant seeks to
increase the total annual application rate to 2.08 lbs a.i./A for tomato
and basil by allowing for up to four crop production seasons per year. 
This proposed multi-season total annual application rate exceeds those
assessed in previous
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(μg/L)	Chronic (μg/L)

Surface Water (FIRST, 1.1.1)	91	Tomato & Basil 

(2.08 lbs a.i./A)	79	9.0

Ground Water (PRZM-GW, 1.01)	N/A	Tomato & Basil 

(2.08 lbs a.i./A)	87	79

Ground Water (SCI-GROW, 2.3)	N/A	Tomato & Basil 

(2.08 lbs a.i./A)	0.18

Abbreviations: A= acre; a.i. = active ingredient; μg = micrograms; lbs
= pounds (US); N/A = not applicable

The Total Residue (TR) modeling approach (USEPA, 2013) was used to
estimate aerobic aquatic half-lives, and estimate drinking water
concentrations in surface waters. Previous drinking water assessments
calculated separate half-lives for the parent compound and two
degradates of concern, for which exposure was estimated with separate
model runs. Simple addition of the exposure estimates for mandipropamid
and it’s degradates of concern was used to generate estimated drinking
water concentrations. Previous authors acknowledge this approach is
conservative because the exposure estimates may not be temporally
coincident. The TR method, however, tallies the parent compound and
it’s degradates of concern prior to calculating a Total Residue
half-life using PestDF.

The PRZM-GW chronic ground water value was higher than the surface water
value.  As a result, the ground water value was incorporated directly
into these dietary assessments under the DEEM-FCID food categories
“water, all sources” and “water, indirect, all sources.”  The
FIRST model and its description are available at the EPA internet site: 
HYPERLINK "http://www.epa.gov/oppefed1/models/water/"
http://www.epa.gov/oppefed1/models/water/ .  

V.	DEEM-FCID™ Program and Consumption Information

The mandipropamid chronic dietary exposure assessment was conducted
using the Dietary Exposure Evaluation Model software with the Food
Commodity Intake Database DEEM-FCID, Version 3.16, which incorporates
2003-2008 consumption data from USDA’s NHANES/WWEIA.  The data are
based on the reported consumption of more than 20,000 individuals over
two non-consecutive survey days.  Foods “as consumed” (e.g., apple
pie) are linked to EPA-defined food commodities (e.g., apples, peeled
fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or
N/S, baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA.  For chronic exposure assessment,
consumption data are averaged for the entire U.S. population and within
population subgroups.  Based on analysis of the 2003-2008 WWEIA
consumption data, which took into account dietary patterns and survey
respondents, HED concluded that it is most appropriate to report risk
for the following population subgroups: the general U.S. population, all
infants (<1 year old), children 1-2, children 3-5, children 6-12, youth
13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For a chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

VI.	Toxicological Information

HED evaluated the toxicology data base of mandipropamid and selected a
dose and endpoint for chronic dietary risk assessment based on evidence
of liver toxicity.  No acute dietary exposure assessment for
mandipropamid has been conducted because no appropriate endpoint
attributable to a single dose was identified.  There were no
treatment-related tumors observed in carcinogenicity studies in rats and
mice and mandipropamid is classified as “Not likely to be a human
carcinogen.”  Therefore, cancer risk is not a concern for this
chemical.  Doses and toxicological endpoints selected for the chronic
dietary exposure scenario are summarized in Table 3.

Table 3.  Summary of Toxicological Doses and Endpoints for Use in
Dietary Human Health Risk Assessments for Mandipropamid

Exposure

Scenario	Dose Used in Risk Assessment, UF 

POD	FQPA SF and Level of Concern for Risk Assessment	Study and
Toxicological Effects

Acute Dietary (All populations, including infants and children)	None

	None	Not selected.

No appropriate dose and endpoint could be identified for any population
group.

Chronic Dietary

(All populations)	NOAEL= 5 mg/kg/day

UFA= 10x

UFH= 10x

Chronic RfD = 0.05 mg/kg/day	FQPA SF =1

cPAD = chronic RfD

                FQPA SF

= 0.05 mg/kg/day	Chronic toxicity – dogs

LOAEL = 40 mg/kg/day, based on  evidence of liver toxicity (increased
incidence and severity of microscopic pigment in the liver and increased
alkaline phosphatase activity in both sexes as well as increased alanine
aminotransferase activity in males).

Cancer (oral, dermal, inhalation)	There were no treatment-related tumors
observed in carcinogenicity studies in rats and mice. Classified as
“Not likely to be a human carcinogen.”

Point of Departure (POD) = A data point or an estimated point that is
derived from observed dose-response data and  used to mark the beginning
of extrapolation to determine risk associated with lower environmentally
relevant human exposures.  NOAEL = no observed adverse effect level. 
LOAEL = lowest observed adverse effect level.  UF = uncertainty factor. 
UFA = extrapolation from animal to human (interspecies).  UFH =
potential variation in sensitivity among members of the human population
(intraspecies).  FQPA SF = FQPA Safety Factor.  PAD = population
adjusted dose (a = acute, c = chronic).  RfD = reference dose. 

VII.	Results/Discussion 

As stated above, for chronic assessments, HED is concerned when dietary
risk exceeds 100% of the PAD.  The DEEM-FCID™ analysis estimates the
dietary exposure of the general U.S. population and various population
subgroups.  Table 4 lists the results of the chronic dietary exposure
analyses for the general U.S. population, all infants (<1 year old),
children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49,
adults 20-49, and adults 50-99 years old. 

Results of Chronic Dietary Exposure Analysis

In the chronic dietary exposure analysis, the most highly exposed
population subgroup is children 1-2 years old which utilizes 47% of the
cPAD (Table 4).  The general U.S. population utilizes 27% of the cPAD.

Table 4.  Summary of Dietary Exposure and Risk for Mandipropamid (Food
and Drinking Water)

Population Subgroup	Acute Dietary	Chronic Dietary	Cancer

	Dietary Exposure (mg/kg/day)	% aPAD	Dietary Exposure

(mg/kg/day)	% cPAD	Dietary Exposure

(mg/kg/day)	Risk

General U.S. Population	N/A	N/A	0.013475	27	N/A	N/A

All Infants (< 1 year old)

	0.011653	23

Children 1-2 years old

	0.022893	46

Children 3-5 years old

	0.020342	41

Children 6-12 years old

	0.012364	25

Youth 13-19 years old

	0.009617	19

Adults 20-49 years old

	0.013459	27

Adults 50-99 years old

	0.013425	27

Females 13-49 years old

	0.013293	27

N/A = Not applicable.

VIII.	Characterization of Inputs/Outputs

DEEM-FCID™.  Tolerance-level residues for all commodities, except
vegetable, tuberous and corm, subgroup 1C, DEEM (ver. 7.81) default
processing factors (except grape, wine and sherry, 1.5X) and 100% crop
treated were assumed for this assessment.  Further refinement to the
analyses could be made through the use of anticipated residues,
incorporation of percent crop treated information with mandipropamid,
and/or monitoring data that better reflect residues at the time of
consumption.  Since risk estimates are below HED’s level of concern, a
more highly refined analysis is not needed at this time.

IX. Conclusions

Based on the conservative assumptions noted above, chronic dietary risk
estimates for mandipropamid do not exceed HED’s level of concern for
the general U.S. population, or any of the population subgroups,
including those comprised of infants and children.  

X.  List of Attachments:

Attachment 1:  Residue Input File for Chronic Analysis

Attachment 2:  Results of Chronic Dietary Exposure Analysis

Attachment 1:   Residue Input File for Chronic (Non-Cancer) Analysis

US EPA                                                          Ver.
3.16, 03-08-d

DEEM-FCID Chronic analysis for MANDIPROPAMID

Residue file: J:\Mandy\deem\036602C.R08                    Adjust. #2
NOT used

Analysis Date 07-25-2013             Residue file dated:
07-25-2013/13:59:50

Reference dose (RfD) = 0.05 mg/kg bw/day

------------------------------------------------------------------------
----------

 Food      Crop                                   Residue      
Adj.Factors

EPA Code    Grp  Food Name                        (ppm)        #1       
 #2 

---------- ---- -------------------------------   ---------- ------    
------

0401005000 4A   Amaranth, leafy                   20.000000   1.000     
1.000   

0103015000 1CD  Arrowroot, flour                   0.026000   1.000     
1.000   

0103015001 1CD  Arrowroot, flour-babyfood          0.026000   1.000     
1.000   

0103017000 1CD  Artichoke, Jerusalem               0.026000   1.000     
1.000   

0401018000 4A   Arugula                           20.000000   1.000     
1.000   

0902021000 9B   Balsam pear                        0.600000   1.000     
1.000   

1901028000 19A  Basil, fresh leaves               30.000000   1.000     
1.000   

1901028001 19A  Basil, fresh leaves-babyfood      30.000000   1.000     
1.000   

1901029000 19A  Basil, dried leaves              200.000000   1.000     
1.000   

1901029001 19A  Basil, dried leaves-babyfood     200.000000   1.000     
1.000   

0601043000 6A   Bean, snap, succulent              0.900000   1.000     
1.000   

0601043001 6A   Bean, snap, succulent-babyfood     0.900000   1.000     
1.000   

0501061000 5A   Broccoli                           3.000000   1.000     
1.000   

0501061001 5A   Broccoli-babyfood                  3.000000   1.000     
1.000   

0501062000 5A   Broccoli, Chinese                  3.000000   1.000     
1.000   

0502063000 5B   Broccoli raab                     25.000000   1.000     
1.000   

0501064000 5A   Brussels sprouts                   3.000000   1.000     
1.000   

0501069000 5A   Cabbage                            3.000000   1.000     
1.000   

0502070000 5B   Cabbage, Chinese, bok choy        25.000000   1.000     
1.000   

0501071000 5A   Cabbage, Chinese, napa             3.000000   1.000     
1.000   

0501072000 5A   Cabbage, Chinese, mustard          3.000000   1.000     
1.000   

0901075000 9A   Cantaloupe                         0.600000   1.000     
1.000   

0402076000 4B   Cardoon                           20.000000   1.000     
1.000   

0103082000 1CD  Cassava                            0.026000   1.000     
1.000   

0103082001 1CD  Cassava-babyfood                   0.026000   1.000     
1.000   

0501083000 5A   Cauliflower                        3.000000   1.000     
1.000   

0402085000 4B   Celery                            20.000000   1.000     
1.000   

0402085001 4B   Celery-babyfood                   20.000000   1.000     
1.000   

0402086000 4B   Celery, juice                     20.000000   1.000     
1.000   

0402087000 4B   Celtuce                           20.000000   1.000     
1.000   

0902088000 9B   Chayote, fruit                     0.600000   1.000     
1.000   

0902102000 9B   Chinese waxgourd                   0.600000   1.000     
1.000   

0302103000 3B   Chive, fresh leaves                7.000000   1.000     
1.000   

0401104000 4A   Chrysanthemum, garland            20.000000   1.000     
1.000   

0502117000 5B   Collards                          25.000000   1.000     
1.000   

0401133000 4A   Cress, garden                     20.000000   1.000     
1.000   

0401134000 4A   Cress, upland                     20.000000   1.000     
1.000   

0902135000 9B   Cucumber                           0.600000   1.000     
1.000   

0401138000 4A   Dandelion, leaves                 20.000000   1.000     
1.000   

0103139000 1CD  Dasheen, corm                      0.026000   1.000     
1.000   

0802148000 8BC  Eggplant                           1.000000   1.000     
1.000   

0401150000 4A   Endive                            20.000000   1.000     
1.000   

0402152000 4B   Fennel, Florence                  20.000000   1.000     
1.000   

0301165000 3A   Garlic, bulb                       0.100000   1.000     
1.000   

0301165001 3A   Garlic, bulb-babyfood              0.100000   1.000     
1.000   

0103166000 1CD  Ginger                             0.026000   1.000     
1.000   

0103166001 1CD  Ginger-babyfood                    0.026000   1.000     
1.000   

0103167000 1CD  Ginger, dried                      0.026000   1.000     
1.000   

0101168000 1AB  Ginseng, dried                     0.300000   1.000     
1.000   

1302174000 13B  Gooseberry                         2.000000   1.000     
1.000   

1304175000 13D  Grape                              2.000000   1.000     
1.000   

1304176000 13D  Grape, juice                       2.000000   1.200     
1.000   

1304176001 13D  Grape, juice-babyfood              2.000000   1.200     
1.000   

9500177000 O    Grape, leaves                      2.000000   1.000     
1.000   

9500178000 O    Grape, raisin                      3.000000   1.000     
1.000   

1304179000 13D  Grape, wine and sherry             2.000000   1.500     
1.000   

0901187000 9A   Honeydew melon                     0.600000   1.000     
1.000   

9500188000 O    Hop                               50.000000   1.000     
1.000   

0502194000 5B   Kale                              25.000000   1.000     
1.000   

0501196000 5A   Kohlrabi                           3.000000   1.000     
1.000   

0302198000 3B   Leek                               7.000000   1.000     
1.000   

0401204000 4A   Lettuce, head                     20.000000   1.000     
1.000   

0401205000 4A   Lettuce, leaf                     20.000000   1.000     
1.000   

0502229000 5B   Mustard greens                    25.000000   1.000     
1.000   

0802234000 8BC  Okra                               1.000000   1.000     
1.000   

0301237000 3A   Onion, bulb                        0.100000   1.000     
1.000   

0301237001 3A   Onion, bulb-babyfood               0.100000   1.000     
1.000   

0301238000 3A   Onion, bulb, dried                 0.100000   9.000     
1.000   

0301238001 3A   Onion, bulb, dried-babyfood        0.100000   9.000     
1.000   

0302239000 3B   Onion, green                       7.000000   1.000     
1.000   

0401248000 4A   Parsley, leaves                   20.000000   1.000     
1.000   

0802270000 8B   Pepper, bell                       1.000000   1.000     
1.000   

0802270001 8B   Pepper, bell-babyfood              1.000000   1.000     
1.000   

0802271000 8B   Pepper, bell, dried                1.000000   1.000     
1.000   

0802271001 8B   Pepper, bell, dried-babyfood       1.000000   1.000     
1.000   

0802272000 8BC  Pepper, nonbell                    1.000000   1.000     
1.000   

0802272001 8BC  Pepper, nonbell-babyfood           1.000000   1.000     
1.000   

0802273000 8BC  Pepper, nonbell, dried             1.000000   1.000     
1.000   

0103296000 1C   Potato, chips                      0.026000   1.000     
1.000   

0103297000 1C   Potato, dry (granules/ flakes)     0.026000   6.500     
1.000   

0103297001 1C   Potato, dry (granules/ flakes)-b   0.026000   6.500     
1.000   

0103298000 1C   Potato, flour                      0.026000   6.500     
1.000   

0103298001 1C   Potato, flour-babyfood             0.026000   6.500     
1.000   

0103299000 1C   Potato, tuber, w/peel              0.026000   1.000     
1.000   

0103299001 1C   Potato, tuber, w/peel-babyfood     0.026000   1.000     
1.000   

0103300000 1C   Potato, tuber, w/o peel            0.026000   1.000     
1.000   

0103300001 1C   Potato, tuber, w/o peel-babyfood   0.026000   1.000     
1.000   

0902308000 9B   Pumpkin                            0.600000   1.000     
1.000   

0902309000 9B   Pumpkin, seed                      0.600000   1.000     
1.000   

0401313000 4A   Radicchio                         20.000000   1.000     
1.000   

0502318000 5B   Rape greens                       25.000000   1.000     
1.000   

0402322000 4B   Rhubarb                           20.000000   1.000     
1.000   

0302338500 3B   Shallot, fresh leaves              7.000000   1.000     
1.000   

0401355000 4A   Spinach                           20.000000   1.000     
1.000   

0401355001 4A   Spinach-babyfood                  20.000000   1.000     
1.000   

0902356000 9B   Squash, summer                     0.600000   1.000     
1.000   

0902356001 9B   Squash, summer-babyfood            0.600000   1.000     
1.000   

0902357000 9B   Squash, winter                     0.600000   1.000     
1.000   

0902357001 9B   Squash, winter-babyfood            0.600000   1.000     
1.000   

0103366000 1CD  Sweet potato                       0.026000   1.000     
1.000   

0103366001 1CD  Sweet potato-babyfood              0.026000   1.000     
1.000   

0402367000 4B   Swiss chard                       20.000000   1.000     
1.000   

0103371000 1CD  Tanier, corm                       0.026000   1.000     
1.000   

0801374000 8A   Tomatillo                          1.000000   1.000     
1.000   

0801375000 8A   Tomato                             1.000000   1.000     
1.000   

0801375001 8A   Tomato-babyfood                    1.000000   1.000     
1.000   

0801376000 8A   Tomato, paste                      1.000000   5.400     
1.000   

0801376001 8A   Tomato, paste-babyfood             1.000000   5.400     
1.000   

0801377000 8A   Tomato, puree                      1.000000   3.300     
1.000   

0801377001 8A   Tomato, puree-babyfood             1.000000   3.300     
1.000   

0801378000 8A   Tomato, dried                      1.000000  14.300     
1.000   

0801378001 8A   Tomato, dried-babyfood             1.000000  14.300     
1.000   

0801379000 8A   Tomato, juice                      1.000000   1.500     
1.000   

0801380000 8A   Tomato, Tree                       1.000000   1.000     
1.000   

0103387000 1CD  Turmeric                           0.026000   1.000     
1.000   

0502389000 5B   Turnip, greens                    25.000000   1.000     
1.000   

8601000000 86A  Water, direct, all sources         0.079000   1.000     
1.000   

8602000000 86B  Water, indirect, all sources       0.079000   1.000     
1.000   

0901399000 9A   Watermelon                         0.600000   1.000     
1.000   

0901400000 9A   Watermelon, juice                  0.600000   1.000     
1.000   

0103406000 1CD  Yam, true                          0.026000   1.000     
1.000   

0103407000 1CD  Yam bean                           0.026000   1.000     
1.000   

0301338000 3A   Shallot, bulb                      0.100000   1.000     
1.000   

Attachment 2:  Results of Chronic Dietary Exposure Analysis

US EPA                                                          Ver.
3.16, 03-08-d

DEEM-FCID Chronic analysis for MANDIPROPAMID               NHANES
2003-2008 2-day

Residue file name: J:\Mandy\deem\036602C.R08     Adjustment factor #2
NOT used.

Analysis Date 07-25-2013/14:00:17     Residue file dated:
07-25-2013/13:59:50

Reference dose (RfD, Chronic) = .05 mg/kg bw/day

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
----------------

Total US Population                         0.013475               
27.0%

Hispanic                                    0.011932               
23.9%

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            27.8%

Non-Hisp-Black                              0.012226               
24.5%

Non-Hisp-Other                              0.014678               
29.4%

Nursing Infants                             0.005723               
11.4%

Non-Nursing Infants                         0.014302               
28.6%

Female 13+ PREG                             0.011797               
23.6%

Children 1-6                                0.020727               
41.5%

Children 7-12                               0.011523               
23.0%

Male 13-19                                  0.009229               
18.5%

Female 13-19/NP                             0.010005               
20.0%

Male 20+                                    0.012668               
25.3%

Female 20+/NP                               0.014206               
28.4%

Seniors 55+                                 0.013238               
26.5%

All Infants                                 0.011653               
23.3%

Female 13-50                                0.013273               
26.5%

Children 1-2                                0.022893               
45.8%

Children 3-5                                0.020342               
40.7%

Children 6-12                               0.012364               
24.7%

Youth 13-19                                 0.009617               
19.2%

Adults 20-49                                0.013459               
26.9%

Adults 50-99                                0.013425               
26.9%

Female 13-49                                0.013293               
26.6%

------------------------------------------------------------------------
-------

Mandipropamid	Dietary Exposure and Risk Assessment	           DP Number:
412238		

Page   PAGE  1  of   NUMPAGES  2