Document ID: EPA-HQ-OPP-2008-0554-0007
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2009-06-02T04:00Z

SEQ CHAPTER \h \r 1 

	UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF           

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM

Date: 		15/JAN/2009

SUBJECT:	Etoxazole.  Chronic Dietary Exposure and Risk Assessment for
the Section 3 Registration Action on Stone Fruits, Cucumber, Greenhouse
Tomato, and Mint.  

		

PC Code:  107091	DP Number:  360769

Decision No.:  392380	Registration Nos.: 59639-138 and 59639-108

Petition No.:  8E7347	Regulatory Action:  Section 3 Registrations

Risk Assessment Type:  Dietary	Case No.:  Not Applicable

TXR No.:  Not Applicable	CAS No.:    SEQ CHAPTER \h \r 1 153233-91-1

MRID No.:  47406201-05	40 CFR:  180.593

FROM:	  SEQ CHAPTER \h \r 1 Debra Rate, Ph.D., Biologist  SEQ CHAPTER \h
\r 1 

		Alternative Risk Integration and Assessment (ARIA)

		Risk Integration, Minor Use, and Emergency Response Branch (RIMUERB)

		Registration Division (RD;7505P)

THROUGH:	David Soderberg, Chemist

Nancy Dodd, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (HED;7509P)

and

William Cutchin, Acting Senior Branch Scientist

ARIA/ RIMUERB/RD (7505P)

TO:		Sidney Jackson, Environmental Specialist

		Minor Use Team

		RIMUERB/RD (7505P)  SEQ CHAPTER \h \r 1   SEQ CHAPTER \h \r 1 

Executive Summary

 conducted using the Dietary Exposure Evaluation Model DEEM-FCID™,
Version 2.03 which use food consumption data from the U.S. Department of
Agriculture’s (USDA’s) Continuing Surveys of Food Intakes by
Individuals (CSFII) from 1994-1996 and 1998.  The analysis was performed
to evaluate establishment of tolerances for residues of etoxazole in/on
stone fruits, cucumber, greenhouse tomatoes, and mint.  Based on the
available toxicological database for etoxazole, only a chronic
assessment was conducted.

The chronic dietary assessment was based on 1) tolerance-level residues
for all agricultural commodities, 2) 100% crop treated (CT), 3)
empirically determined processing factors, when available, or DEEM 7.81
default processing factors, and 4) directly incorporated modeled
estimated drinking water concentrations (EDWCs) for etoxazole.  

The chronic dietary exposure estimates are below ARIA’s level of
concern (<100% cPAD) for the general U.S. population (2% cPAD) and all
population subgroups.  The most highly exposed population subgroup is
children 1-2 years old at 10% of the cPAD.

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the PAD.  The PAD is equivalent
to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the
required uncertainty or safety factors.

For acute and non-cancer chronic exposures, ARIA/HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  References which
discuss the acute and chronic risk assessment in more detail are
available on the EPA/pesticides web site:  “Available Information on
Assessing Exposure from Pesticides, A User’s Guide,” 21/JUN/2000,
web link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf
; or see SOP 99.6 (20/AUG/1999).

The most recent dietary risk assessment for etoxazole was conducted by
J. Tyler (DP Num: 346200, J. Tyler, 06/NOV/2007).

II.	Residue Information

Registered and Proposed Tolerances:  Etoxazole is currently registered
in the U.S. for the control of mites on various raw agricultural
commodities (RACs).  Permanent tolerances have been established for
residues of etoxazole in/on a few assorted plant and livestock
commodities (40 CFR §180.593).  The current petition is for the
establishment of tolerances for residues of etoxazole in/on stone
fruits, cucumber, greenhouse tomatoes and mint.  Table 2 lists both the
existing tolerances and the ARIA recommended tolerances for stone
fruits, cucumber, greenhouse tomatoes and mint.

Nature of the Residue:  On 23/APR/2003, the HED Metabolism Assessment
Review Committee (MARC) met to determine the residues of concern in
plant and livestock commodities (Memo, DP Num: 288817, J. Tyler et al.,
24/APR/2003; TXR No. 0051966).  For apples, oranges, eggplant and
cottonseed, MARC concluded that the residue of concern for both
tolerance expression and risk assessment is parent only (Memo, DP Num:
289666, J. Tyler, 17/JUN/2003).  For cotton gin byproducts, the residue
of concern for tolerance expression is parent only.  For risk assessment
the residues of concern in cotton gin byproducts and almond hulls are
parent and Metabolite R-3.  For ruminant muscle, fat and milk, the
residue of concern for tolerance expression and risk assessment is
parent only.  For ruminant liver and kidney, the residue of concern for
tolerance expression is parent only, but parent and Metabolite 1 should
be included in the risk assessment.

The metabolites of concern for risk assessment purposes in cotton gin
byproducts (etoxazole and Metabolite R-3) and ruminant liver and kidney
(etoxazole and Metabolite 1) were included in previous dietary exposure
assessment (DP Num: 291694, J. Tyler, 29/JUL/2003).  In order to include
the residues of concern in almond hulls (parent and Metabolite R-3), the
residues of concern for risk assessment purposes (etoxazole and
Metabolite 1) were taken from the previous DEEM memo (DP Num: 346200, J.
Tyler, 06/NOV/2007).  As the calculated residue level (etoxazole and
Metabolite 1) for liver is less than the established tolerance of 0.01
ppm, the tolerance-level residue was used in the chronic dietary
exposure assessment.  The residue values for risk assessment purposes
are listed in Table 2.

Drinking Water Considerations:  The Environmental Fate and Effects
Division (EFED) provided EDWCs of etoxazole and the metabolites of
concern (R-8 and R-13) in surface and ground water using the Food
Quality Protection Act (FQPA) Index Reservoir Screening Tool (FIRST) and
Screening Concentration in Ground Water (SCI-GROW) models, respectively
(DP Num: 352617, J. Meléndez, 19/DEC/2008).  The assessment was based
on the proposed mint use which has a maximum proposed seasonal
application rate of 0.36 lb ai/A.  EFED calculated the 1-in-10-year
estimated annual mean non-cancer chronic EDWCs for etoxazole, R-8 and
R-13 in surface water to be 4.761 ppb.  The ground water EDWC for
chronic exposures is estimated as 0.746 ppb.

Table 1.  Estimated Drinking Water Concentrations for Etoxazole and
Metabolites for Chronic Analysis  

	Etoxazole

(ppb)	R-8

(ppb)	R-13

(ppb)	Total

(ppb)

	Surface Water	0.618	4.08	0.063	4.761	One application on Mint at 0.36 lb
ai/A/season

Ground Water	3.46E-03	7.42E-01	6.44E-4	0.746

	

Percent Crop Treated:  For the chronic assessment, it was assumed that
100% of the registered and proposed crops have been treated with
etoxazole.

Residue and PDP Data:  HED-recommended tolerance level residues were
used for all registered and proposed commodities in the chronic
assessment.

Processing Factors:  Available processing data indicate that residues of
etoxazole do not concentrate in apple juice, cottonseed hulls, meal and
oil (DP Num: 283737, J. Tyler, 31/JUL/2003); the processing factor was
set to 1 for these commodities.  A citrus processing study was not
submitted in support of the tangerine tolerance; therefore, the default
DEEM 7.81 processing factor was used for tangerine juice (2.3x).  An
adequate grape processing study is not available.  However, using the
Office of Prevention, Pesticides, and Toxic Substances (OPPTS) guideline
theoretical concentration factors for grape juice and raisins, and the
highest-average field trial (HAFT) value from the submitted crop field
trials, HED previously determined that a tolerance for grape juice was
not needed, but a tolerance of 1.5 ppm for raisin was established (DP
Num: 303628, J. Tyler, 30/MAR/2005).  The processing factor for grape
juice was set to 1.  Adequate processing studies were not provided for
stone fruit commodities, thus default DEEM 7.81 processing factors were
set for appropriate stone fruit commodities, except plum/prune
commodities for which processing factors were set to 1.  A processing
study is not needed for greenhouse tomatoes since they are used for
fresh market only (e-mail from Bernard Schneider to D. Rate dated
01/OCT/2008).  See Table 2 for a complete list of the processing factors
used in this assessment.



Table 2.  HED-Recommended Tolerances and Residue Values for Risk
Assessment Purposes.

Commodity	Recommended/Established Tolerance (ppm)1	Residue Values for
Chronic Dietary Exposure Assessment (ppm)2	Processing Factors

Proposed Uses

Fruit, Stone, Crop Group 12, except plum	 1.0	1.0	Default values
(Appricots-dried = 6.0; cherries-juice = 1.5; peaches-dried = 7.0)

Plum	0.15	0.15	Not applicable (NA)

Plum, prune, dried	0.30	0.30	1.0 

Spearmint, tops	  10	10

	Peppermint, tops	  10	10

	Spearmint, oil	  20	20	1.0

Peppermint, oil	  20	20	1.0

Cucumber	0.20	0.20

	Tomato	0.02	0.02	Greenhouse use for fresh market only.  No processed
tomato commodities included in the analysis.

Registered Uses

Cherry	 1.0	deleted	NA

Hop, dried cones	 7.0	 7.0	NA

Vegetable, cucurbit subgroup 9A	0.20	0.20	NA

Nut, tree, group 14	0.01	0.01	NA

Almond, hulls	 2.0	 NA7	NA

Pistachio	0.01	0.01	NA

Grape	 0.5	 0.5	Grape, juice=1.0 (default value set to 1); Grape, leaves
= 1.0 (default value); Grape, wine and sherry=1.0 (default value);
Grape, raisin=see below.

Grape, raisin	 1.5	 1.5	Default value set to 1.0.

Fruit, Pome, Group 11	0.20	0.20	Apple, juice=1.0 (default value set to
1); Apple, dried=8.0 (default value); Apple, sauce=1.0 (default value);
Pear, dried=6.25 (default value); Pear, juice =1.0 (default value).

Apple, pomace wet	0.50	 NA3	NA

Strawberry	0.50	0.50	Strawberry, juice=1.0 (default value).

Cottonseed	0.05	0.05	Cottonseed, oil=1.0 (default value).

Cotton Gin Byproducts	 1.0	 NA4	NA

Tangerine	0.10	0.10	Tangerine, juice=2.3 (default value).

Liver* 	0.01	0.015	NA

Kidney*, 6	  NA	0.0067	NA

Fat*	0.02	0.02	NA

Milk, fat	0.01	0.01	NA

* of cattle, goat, horse, and sheep

1. The residue of concern for tolerance purposes for all plant and
livestock commodities is parent only.

2.  Residues to be included in risk assessment for cotton by-products
are parent and Metabolite R-3.  Residues to be included in risk
assessment for ruminant liver and kidney are parent and Metabolite 1. 
For all other commodities, the residue included in the risk assessment
is parent only.

3. As this wet apple pomace is a livestock feed item only, it was not
included in the chronic dietary exposure assessment.

4.  For chronic dietary exposure assessment, the average combined
residue (parent and Metabolite R-3) was determined to be 0.43 ppm, which
is less than the HED-recommended tolerance of 1.0 ppm.  Therefore,
HED-recommended tolerance level of 1.0 ppm was used to calculate the
appropriate livestock diet for risk assessment purposes.  As this cotton
gin byproducts is a livestock feed item only, it was not included in the
chronic dietary exposure assessment.

5.  The calculated residue level (etoxazole and Metabolite 1) of 0.0025
ppm is less than the HED-recommended tolerance of 0.01 ppm.  Therefore,
the tolerance-level residue will be used in the chronic dietary exposure
assessment.

6.  The results of the submitted livestock feeding study indicate that
tolerances for residues of etoxazole are not needed for livestock kidney
[180.6(a)(3)].  However, as quantifiable residues of Metabolite 1 (a
residue of concern for risk assessment purposes) were measured in kidney
in the feeding study, kidney (parent and Metabolite 1) was included in
the risk assessment.

7.  Almond hulls are a livestock feed item only.  The HED-recommended
tolerance of 2.0 ppm was used when calculating the maximum theoretical
dietary burden (MTDB) (DP Num: 303628, J. Tyler; 30/MAR/2005).  The HAFT
combined residue (etoxazole and Metabolite R-3) for almonds was 1.57
ppm, which is less than the HED-recommended tolerance of 2.0 ppm.

III.		Program and Consumption Information

 conducted using DEEM-FCID™ (Version 2.03), which incorporates
consumption data from USDA’s CSFII, 1994-1996 and 1998.  The 1994-96,
98 data are based on the reported consumption of more than 20,000
individuals over two non-consecutive survey days.  Foods “as
consumed” (e.g., apple pie) are linked to EPA-defined food commodities
(e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicly available recipe
translation files developed jointly by USDA/ARS and EPA.  Consumption
data are averaged for the entire U.S. population and within population
subgroups for chronic exposure assessment.

For chronic exposure and risk assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form.  The resulting residue
consumption estimate for each food/food form is summed with the residue
consumption estimates for all other food/food forms on the commodity
residue list to arrive at the total average estimated exposure. 
Exposure is expressed in mg/kg body weight/day and as a percent of the
cPAD.  This procedure is performed for each population subgroup.

IV.		Toxicological Information

Etoxazole was presented to the HED Hazard Identification Assessment
Review Committee (HIARC) on 04/FEB/2003 (Memo, PV Shah, 19/MAR/2003; TXR
No. 0051659).  Based on the HIARC conclusions and the Etoxazole risk
assessment team’s evaluation of the hazard and exposure data, the team
recommended that the FQPA Safety Factor be reduced to 1x.  A summary of
the toxicological doses and endpoints selected for dietary exposure
assessment is provided in Table 3.



Table 3.  Summary of Toxicological Dose and Endpoints for Etoxazole for
Use in Human Health Risk Assessment.

Exposure/

Scenario	Point of Departure	Uncertainty/ FQPA Safety Factors	RfD, PAD,
Level of Concern 	Study and Toxicological Effects

Acute Dietary

(Females 13-50 years of age; as well as General population including
infants and children)	

An appropriate endpoint attributable to a single dose was not
identified. 

Chronic Dietary

(All populations)	NOAEL= 4.62 mg/kg/day

	UFA = 10X

UFH = 10X

FQPA SF = 1X	Chronic RfD = 0.046 mg/kg/day

cPAD = chronic RfD

                FQPA SF

= 0.046 mg/kg/day	Chronic toxicity – dogs

LOAEL = 40 mg/kg/day, based on  evidence of liver toxicity (increased
incidence and severity of microscopic pigment in the liver and increased
alkaline phosphatase activity in both sexes as well as increased alanine
aminotransferase activity in males).

Cancer (oral, dermal, inhalation)	The HIARC classified etoxazole as
“not likely to be carcinogenic to humans” according to EPA Proposed
Guidelines for Carcinogen Risk Assessment (April 10, 1996).

Point of Departure (POD) = A data point or an estimated point that is
derived from observed dose-response data and  used to mark the beginning
of extrapolation to determine risk associated with lower environmentally
relevant human exposures.  NOAEL = no observed adverse effect level. 
LOAEL = lowest observed adverse effect level.  UF = uncertainty factor. 
UFA = extrapolation from animal to human (interspecies).  UFH =
potential variation in sensitivity among members of the human population
(intraspecies).  UFL = use of a LOAEL to extrapolate a NOAEL.  UFS = use
of a short-term study for long-term risk assessment.  UFDB = to account
for the absence of key data (i.e., lack of a critical study).  FQPA SF =
FQPA Safety Factor.  PAD = population adjusted dose (a = acute, c =
chronic).  RfD = reference dose.

V.		Results/Discussion/Conclusions

The DEEM-FCID™ analysis estimates the dietary exposure of the U.S.
population and 26 population subgroups.  The results reported in Table 4
are for the U.S. Population, all infants (<1 year old), children 1-2,
children 3-5, children 6-12, youth 13-19, females 13-49, males 20-49,
and adults 50+ years.

The results of the DEEM chronic dietary exposure analyses for etoxazole
are reported in Table 4 and Appendix 2.  This assessment concludes that
for all supported commodities, the chronic dietary exposure estimates
are below ARIA’s level of concern.  The DEEM chronic dietary exposure
estimate for the highest exposed population subgroup, children 1-2 years
of age, is 10% of the cPAD and it is 2% of the cPAD for the general U.S.
population.



Table 4.  Summary of Dietary Exposure and Risk for Etoxazole.

Population

Subgroup	Acute Dietary1	Chronic Dietary2,3

	Dietary Exposure

(mg/kg/day)	% aPAD	Dietary Exposure

(mg/kg/day)	% cPAD

U.S. Population (total)	Not applicable.	0.000993	2

All Infants (< 1 year old)

0.003434	8

Children 1-2 years old

0.004592	10

Children 3-5 years old

0.002960	6

Children 6-12 years old

0.001303	3

Youth 13-19 years old

0.000557	1

Adults 20-49 years old

0.000630	1

Adults 50+ years old

0.000731	2

Females 13-49 years old

0.000627	1

1 No acute dietary endpoint was chosen for the general U.S. population
or any population subgroup, including infants and children.

2 Chronic dietary endpoint of 0.046 mg/kg/day applies to the general
U.S. population and all population subgroups.

3 Population subgroup with the highest exposure and risk is in bold
type.  %cPAD is shown to nearest whole number.

VI.		List of Attachments

EEM-FCID™ Analysis.

Attachment 2.  Chronic DEEM-FCID™ Analysis.

cc (w/ Attachments): D. Rate (RIMUERB), S. Jackson (RIMUERB)

RDI: DE SAC [ D. Soderberg (01/06/09), N. Dodd (01/07/09)]; W. Cutchin
(01/14/09)

D. Rate:S7822:(703)306-0309: 7505P:RIMUERB

Attachment 1.  Residue File for Chronic DEEM-FCID™ Analysis.

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for ETOXAZOLE                         
1994-98 data

Residue file: E:\Current Working Files\Etoxazole\Dietary\010809\chronic
107091.r98

                                                           Adjust. #2
NOT used

Analysis Date 01-08-2009             Residue file dated:
01-08-2009/13:15:43/8

Reference dose (RfD) = 0.046  (NOEL) = 4.62 mg/kg bw/day

Comment:Section 3 for use on stone fruit, cucumber, greenhouse tomato
and mint.

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

14000030 14   Almond                             0.010000   1.000     
1.000   Parent

  Full comment: Parent only

14000031 14   Almond-babyfood                    0.010000   1.000     
1.000   Parent

  Full comment: Parent only

14000040 14   Almond, oil                        0.010000   1.000     
1.000   Parent

  Full comment: Parent only

14000041 14   Almond, oil-babyfood               0.010000   1.000     
1.000   Parent

  Full comment: Parent only

11000070 11   Apple, fruit with peel             0.200000   1.000     
1.000   Parent

  Full comment: Parent only

11000080 11   Apple, peeled fruit                0.200000   1.000     
1.000   Parent

  Full comment: Parent only

11000081 11   Apple, peeled fruit-babyfood       0.200000   1.000     
1.000   Parent

  Full comment: Parent 

only

11000090 11   Apple, dried                       0.200000   8.000     
1.000   Parent

  Full comment: Parent only; Default processing factor.

11000091 11   Apple, dried-babyfood              0.200000   8.000     
1.000   Parent

  Full comment: Parent only; Default processing factor set to 1.

11000100 11   Apple, juice                       0.200000   1.000     
1.000   Parent

  Full comment: Parent only; Default processing factor set to 1.

11000101 11   Apple, juice-babyfood              0.200000   1.000     
1.000   Parent

  Full comment: Parent only; Default processing factor set to 1.

11000110 11   Apple, sauce                       0.200000   1.000     
1.000   Parent

  Full comment: Parent only

11000111 11   Apple, sauce-babyfood              0.200000   1.000     
1.000   Parent

  Full comment: Parent only

12000120 12   Apricot                            1.000000   1.000     
1.000   New, P

  Full comment: New, Parent only

12000121 12   Apricot-babyfood                   1.000000   1.000     
1.000   New, P

  Full comment: New, Parent only

12000130 12   Apricot, dried                     1.000000   6.000     
1.000   New, P

  Full comment: New, Parent only; Default processing factor.

12000140 12   Apricot, juice                     1.000000   1.000     
1.000   New, P

  Full comment: New, Parent only

12000141 12   Apricot, juice-babyfood            1.000000   1.000     
1.000   New, P

  Full comment: New, Parent only

21000470 M    Beef, fat                          0.020000   1.000     
1.000   Parent

  Full comment: Parent only

21000471 M    Beef,fat-babyfood                  0.020000   1.000     
1.000   Parent

  Full comment: Parent only

21000480 M    Beef, kidney                       0.006700   1.000     
1.000   Parent

  Full comment: Parent and Metabolite 1

21000490 M    Beef, liver                        0.010000   1.000     
1.000   Parent

  Full comment: Parent and Metabolite 1

21000491 M    Beef, liver-babyfood               0.010000   1.000     
1.000   Parent

  Full comment: Parent and 

Metabolite 1

14000590 14   Brazil nut                         0.010000   1.000     
1.000   Parent

  Full comment: Parent only

14000680 14   Butternut                          0.010000   1.000     
1.000   Parent

  Full comment: Parent only

09010750 9A   Cantaloupe                         0.200000   1.000     
1.000   Parent

  Full comment: Parent only

09010800 9A   Casaba                             0.200000   1.000     
1.000   Parent

  Full comment: Parent only

14000810 14   Cashew                             0.010000   1.000     
1.000   Parent

  Full comment: Parent only

12000900 12   Cherry                             1.000000   1.000     
1.000   Parent

  Full comment: Parent only

12000901 12   Cherry-babyfood                    1.000000   1.000     
1.000   Parent

  Full comment: Parent only

12000910 12   Cherry, juice                      1.000000   1.500     
1.000   Parent

  Full comment: Parent only; Default processing factor.

12000911 12   Cherry, juice-babyfood             1.000000   1.500     
1.000   Parent

  Full comment: Parent only; Default processing factor.

14000920 14   Chestnut                           0.010000   1.000     
1.000   Parent

  Full comment: Parent only

95001280 O    Cottonseed, oil                    0.050000   1.000     
1.000   Parent

  Full comment: Parent only; Default processing factor.

95001281 O    Cottonseed, oil-babyfood           0.050000   1.000     
1.000   Parent

  Full comment: Parent only; Default processing factor.

11001290 11   Crabapple                          0.200000   1.000     
1.000   Parent

  Full comment: Parent only

09021350 9B   Cucumber                           0.200000   1.000     
1.000   Parent

  Full comment: Parent only

14001550 14   Filbert                            0.010000   1.000     
1.000   Parent

  Full comment: Parent only

14001560 14   Filbert, oil                       0.010000   1.000     
1.000   Parent

  Full comment: Parent only

23001710 M    Goat, fat                          0.020000   1.000     
1.000   Parent

  Full comment: Parent only

23001720 M    Goat, kidney                       0.006700   1.000     
1.000   Parent

  Full comment: Parent and Metabolite 1

23001730 M    Goat, liver                        0.010000   1.000     
1.000   Parent

  Full comment: Parent and Metabolite 1

95001750 O    Grape                              0.500000   1.000     
1.000   Parent

  Full comment: Parent only

95001760 O    Grape, juice                       0.500000   1.000     
1.000   Proces

  Full comment: Processing factor set to one; parent only

95001761 O    Grape, juice-babyfood              0.500000   1.000     
1.000   Proces

  Full comment: Processing factor set to one; parent only

95001770 O    Grape, leaves                      0.500000   1.000     
1.000   Parent

  Full comment: Parent only

95001780 O    Grape, raisin                      1.500000   1.000     
1.000   Proces

  Full comment: Processing factor set to one; parent only

95001790 O    Grape, wine and sherry             0.500000   1.000     
1.000   Parent

  Full comment: Parent only

14001850 14   Hickory nut                        0.010000   1.000     
1.000   Parent

  Full comment: Parent only

09011870 9A   Honeydew melon                     0.200000   1.000     
1.000   Parent

  Full comment: Parent only

95001880 O    Hop                                7.000000   1.000     
1.000   Parent

  Full comment: Parent only

11002100 11   Loquat                             0.200000   1.000     
1.000   Parent

  Full comment: Parent only

14002130 14   Macadamia nut                      0.010000   1.000     
1.000   Parent

  Full comment: Parent only

27002220 D    Milk, fat                          0.010000   1.000     
1.000   Parent

  Full comment: Parent only

27002221 D    Milk, fat - baby food/infant for   0.010000   1.000     
1.000   Parent

  Full comment: Parent only

12002300 12   Nectarine                          1.000000   1.000     
1.000   New, P

  Full comment: New, Parent only

12002600 12   Peach                              1.000000   1.000     
1.000   New, P

  Full comment: New, Parent only

12002601 12   Peach-babyfood                     1.000000   1.000     
1.000   New, P

  Full comment: New, Parent only

12002610 12   Peach, dried                       1.000000   7.000     
1.000   New, P

  Full comment: New, Parent only; Default processing factor.

12002611 12   Peach, dried-babyfood              1.000000   7.000     
1.000   New, P

  Full comment: New, Parent only; Default processing factor.

12002620 12   Peach, juice                       1.000000   1.000     
1.000   New, P

  Full comment: New, Parent only

12002621 12   Peach, juice-babyfood              1.000000   1.000     
1.000   New, P

  Full comment: New, Parent only

11002660 11   Pear                               0.200000   1.000     
1.000   Parent

  Full comment: Parent only

11002661 11   Pear-babyfood                      0.200000   1.000     
1.000   Parent

  Full comment: Parent only

11002670 11   Pear, dried                        0.200000   6.250     
1.000   Parent

  Full comment: Parent only; Default processing factor.

11002680 11   Pear, juice                        0.200000   1.000     
1.000   Parent

  Full comment: Parent only

11002681 11   Pear, juice-babyfood               0.200000   1.000     
1.000   Parent

  Full comment: Parent only

14002690 14   Pecan                              0.010000   1.000     
1.000   Parent

  Full comment: Parent only

95002750 O    Peppermint                        10.000000   1.000     
1.000   New, P

  Full comment: New, Parent only

95002760 O    Peppermint, oil                   20.000000   1.000     
1.000   New, P

  Full comment: New, Parent only

14002820 14   Pistachio                          0.010000   1.000     
1.000   Parent

  Full comment: Parent only

12002850 12   Plum                               0.150000   1.000     
1.000   New, P

  Full comment: New, Parent only

12002851 12   Plum-babyfood                      0.150000   1.000     
1.000   New, P

  Full comment: New, Parent only

12002860 12   Plum, prune, fresh                 0.300000   1.000     
1.000   New, P

  Full comment: New, Parent only

12002861 12   Plum, prune, fresh-babyfood        0.300000   1.000     
1.000   New, P

  Full comment: New, Parent only

12002870 12   Plum, prune, dried                 0.300000   1.000     
1.000   New,Pa

  Full comment: New,Parent only; Default PF set to 1.

12002871 12   Plum, prune, dried-babyfood        0.300000   1.000     
1.000   New,Pa

  Full comment: New,Parent only; Default PF set to 1.

12002880 12   Plum, prune, juice                 0.300000   1.000     
1.000   New,Pa

  Full comment: New,Parent only; Default PF set to 1.

12002881 12   Plum, prune, juice-babyfood        0.300000   1.000     
1.000   New,Pa

  Full comment: New,Parent only; Default PF set to 1.

11003100 11   Quince                             0.200000   1.000     
1.000   Parent

  Full comment: Parent only

26003410 M    Sheep, fat                         0.020000   1.000     
1.000   Parent

  Full comment: Parent only

26003411 M    Sheep, fat-babyfood                0.020000   1.000     
1.000   Parent

  Full comment: Parent only

26003420 M    Sheep, kidney                      0.006700   1.000     
1.000   Parent

  Full comment: Parent and Metabolite 1

26003430 M    Sheep, liver                       0.010000   1.000     
1.000   Parent

  Full comment: Parent and Metabolite 1

95003520 O    Spearmint                         10.000000   1.000     
1.000   New, P

  Full comment: New, Parent only

95003530 O    Spearmint, oil                    20.000000   1.000     
1.000   New, P

  Full comment: New, Parent only

95003590 O    Strawberry                         0.500000   1.000     
1.000   Parent

  Full comment: Parent only

95003591 O    Strawberry-babyfood                0.500000   1.000     
1.000   Parent

  Full comment: Parent only

95003600 O    Strawberry, juice                  0.500000   1.000     
1.000   Parent

  Full comment: Parent only; Default processing factor.

95003601 O    Strawberry, juice-babyfood         0.500000   1.000     
1.000   Parent

  Full comment: Parent only; Default processing factor.

10003690 10   Tangerine                          0.100000   1.000     
1.000   Parent

  Full comment: Parent only

10003700 10   Tangerine, juice                   0.100000   2.300     
1.000   Parent

  Full comment: Parent only; Default processing factor.

08003750 8    Tomato                             0.020000   1.000     
1.000   New, P

  Full comment: New, Parent only Fresh Market only

08003751 8    Tomato-babyfood                    0.020000   1.000     
1.000   New, P

  Full comment: New, Parent only Fresh Market only

14003910 14   Walnut                             0.010000   1.000     
1.000   Parent

  Full comment: Parent only

86010000 O    Water, direct, all sources         0.004761   1.000     
1.000   EDWC =

  Full comment: EDWC = 4.761 ppb 

86020000 O    Water, indirect, all sources       0.004761   1.000     
1.000   EDWC =

  Full comment: EDWC = 4.761 ppb

09013990 9A   Watermelon                         0.200000   1.000     
1.000   Parent

  Full comment: Parent only

09014000 9A   Watermelon, juice                  0.200000   1.000     
1.000   Parent

  Full comment: Parent only

Attachment 2.  Chronic DEEM-FCID™ Analysis.

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for ETOXAZOLE                        (1994-98
data)

Residue file name: E:\Current Working
Files\Etoxazole\Dietary\010809\chronic 107091.r98

                                                 Adjustment factor #2
NOT used.

Analysis Date 01-08-2009/13:16:23     Residue file dated:
01-08-2009/13:15:43/8

Reference dose (RfD, Chronic) = .046 mg/kg bw/day

NOEL (Chronic) = 4.62 mg/kg bw/day

COMMENT 1: Section 3 for use on stone fruit, cucumber, greenhouse tomato
and mint.

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg       Margin of  
Percent 

           Subgroup                       body wt/day   Exposure 1/  of
RfD 

--------------------------------------   -------------  ---------- 
---------

U.S. Population (total)                     0.000993        4,653       
2.2%

U.S. Population (spring season)             0.001002        4,610       
2.2%

U.S. Population (summer season)             0.001168        3,954       
2.5%

U.S. Population (autumn season)             0.000892        5,182       
1.9%

U.S. Population (winter season)             0.000909        5,083       
2.0%

Northeast region                            0.001066        4,334       
2.3%

Midwest region                              0.001017        4,545       
2.2%

Southern region                             0.000858        5,382       
1.9%

Western region                              0.001116        4,140       
2.4%

Hispanics                                   0.000982        4,705       
2.1%

Non-hispanic whites                         0.001012        4,563       
2.2%

Non-hispanic blacks                         0.000869        5,318       
1.9%

Non-hisp/non-white/non-black                0.001055        4,380       
2.3%

All infants (< 1 year)                      0.003434        1,345       
7.5%

Nursing infants                             0.001885        2,452       
4.1%

Non-nursing infants                         0.004022        1,149
†††㠠㜮ഥ桃汩牤湥ㄠ㘭†特⁳†††††††††
††††⸰〰㌳㈳††††ⰱ㠳‶†††㜠㈮ഥ桃汩牤
湥㜠ㄭ′特⁳†††††††††††††⸰〰ㄱ〹†
†††ⰳ㠸‴†††㈠㘮ഥ䘍浥污獥ㄠⴳ㤱⠠潮⁴牰来
漠⁲畮獲湩⥧††††〠〮〰㠵′†††㜠㤬㐴†††
†⸱┳



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혈0鐂뛿

Females 20+ (not preg or nursing)           0.000674        6,859       
1.5%

Females 13-50 yrs                           0.000690        6,693       
1.5%

Females 13+ (preg/not nursing)              0.000746        6,190       
1.6%

Females 13+ (nursing)                       0.000952        4,855       
2.1%

Males 13-19 yrs                             0.000534        8,654       
1.2%

Males 20+ yrs                               0.000653        7,074       
1.4%

Seniors 55+                                 0.000754        6,125       
1.6%

Children 1-2 yrs                            0.004592        1,006      
10.0%

Children 3-5 yrs                            0.002960        1,561       
6.4%

Children 6-12 yrs                           0.001303        3,546       
2.8%

Youth 13-19 yrs                             0.000557        8,291       
1.2%

Adults 20-49 yrs                            0.000630        7,336       
1.4%

Adults 50+ yrs                              0.000731        6,322       
1.6%

Females 13-49 yrs                           0.000627        7,373       
1.4%

Etoxazole	                               Dietary Exposure and Risk
Assessment	                         DP Num: 360769

PC Code:  107091

________________________________________________________________________
_____________________

 PAGE   14 

Page   PAGE  1  of   NUMPAGES  13