Document ID: EPA-HQ-OPP-2004-0395-0004
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2005-02-09T05:00Z

Page
1
of
6
February
9,
2005
FIFRA
SCIENTIFIC
ADVISORY
PANEL
(
SAP)
OPEN
MEETING
MARCH
1­
2,
2005
FIFRA
SAP
WEB
SITE
http://
www.
epa.
gov/
scipoly/
sap/
OPP
Docket
Telephone:
(
703)
305­
5805
Docket
Number:
OPP­
2004­
0395
SCIENTIFIC
ISSUES
ASSOCIATED
WITH
THE
HUMAN
HEALTH
ASSESSMENT
OF
THE
CRY
34Ab1
PROTEIN
PANEL
MEMBER
BIOGRAPHICAL
SKETCHES
FIFRA
SAP
MEMBERS
Stephen
M.
Roberts,
Ph.
D.

Dr.
Steve
Roberts
is
Director
of
the
Center
for
Environmental
&
Human
Toxicology
at
the
University
of
Florida,
and
is
a
Professor
with
joint
appointments
in
the
Department
of
Physiological
Sciences
in
the
College
of
Veterinary
Medicine
and
the
Department
of
Pharmacology
and
Therapeutics
in
the
College
of
Medicine.
He
received
his
Ph.
D.
from
the
University
of
Utah
College
of
Medicine
in
1977,
and
subsequently
completed
a
National
Institutes
of
Health
(
NIH)
individual
postdoctoral
fellowship
in
pharmacokinetics
at
SUNY
Buffalo.
He
has
previously
served
on
the
faculties
of
the
College
of
Pharmacy
at
the
University
of
Cincinnati
and
the
College
of
Medicine
at
the
University
of
Arkansas
for
Medical
Sciences.
Dr.
Roberts
has
an
active
research
program
funded
by
the
NIH
to
examine
mechanisms
of
toxicity,
primarily
involving
the
liver
and
immune
system.
His
teaching
responsibilities
at
the
University
of
Florida
include
graduate
courses
in
toxicology
and
risk
assessment,
as
well
as
invited
lectures
in
other
graduate
and
professional
courses.
Dr.
Roberts
serves
as
an
advisor
to
the
Florida
Department
of
Environmental
Protection
on
issues
pertaining
to
toxicology
and
risk
assessment.
He
also
serves
on
the
committee
on
Bioavailability
of
Contaminants
in
Soils
and
Sediments
for
the
National
Research
Council
and
on
the
Board
of
Scientific
Counselors
of
the
National
Toxicology
Program.

Steven
G.
Heeringa,
Ph.
D.

Dr.
Steven
G.
Heeringa
is
a
Research
Scientist
and
the
Director
of
the
Statistical
Design
Group
at
the
University
of
Michigan
Institute
for
Social
Research
(
ISR)
where
he
oversees
statistical
design
and
for
population­
based
studies
in
the
social
sciences,
education,
demography,
public
health
and
medicine.
Steve
has
a
Ph.
D.
in
Biostatistics
from
the
University
of
Michigan
and
is
a
specialist
in
statistical
design
and
analysis
for
studies
of
human
and
animal
populations.
Steve
Heeringa
has
over
twenty­
five
years
of
statistical
sampling
experience
directing
the
development
of
the
ISR
National
Sample
design
as
well
as
sample
designs
for
ISR's
major
longitudinal
and
cross­
sectional
survey
programs.
During
this
period
he
has
been
actively
involved
in
research
and
publication
on
statistical
methods
and
procedures
such
as
weighting,
variance
estimation
and
the
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2
of
6
imputation
of
missing
data
that
are
required
in
the
analysis
of
sample
survey
data.
He
is
an
advisor
to
panels
of
the
National
Institutes
of
Health
(
NIH)
and
the
World
Health
Organization
(
WHO).
Since
2000,
Steve
has
served
as
an
ad
hoc
member
of
more
than
10
EPA
Scientific
Review
panels.
He
has
been
a
teacher
of
survey
sampling
methods
to
U.
S.
and
international
students
and
has
served
as
a
sample
design
consultant
to
a
wide
variety
of
international
research
programs
based
in
countries
such
as:
Russia,
the
Ukraine,
Uzbekistan,
Kazakhstan,
India,
Nepal,
China,
Iran,
Chile
and
Egypt.

Stuart
Handwerger,
M.
D.

Dr.
Stuart
Handwerger
is
the
Robert
and
Mary
Shoemaker
Professor
of
Pediatrics
and
Director
of
Endocrinology
at
the
University
of
Cincinnati/
Cincinnati
Children's
Hospital
Medical
Center.
He
is
also
Professor
of
Cell
Biology,
Neurobiology
and
Anatomy,
Director
of
Postgraduate
Medical
Education
at
Children's
Hospital
and
a
member
of
the
Comprehensive
Cancer
Center
at
the
University
of
Cincinnati.
He
received
his
BA
from
the
Johns
Hopkins
University
in
1960
and
his
M.
D.
from
the
University
of
Maryland
School
of
Medicine
in
1964.
He
completed
his
house
staff
training
in
pediatrics
at
the
Bronx
Municipal
Hospital
Center
and
the
Mt.
Sinai
Hospital
in
New
York
City.
After
spending
two
years
as
a
Clinical
Associate
at
the
National
Institutes
of
Health,
he
completed
fellowship
training
in
endocrinology
at
the
Boston
Children's
Hospital
and
the
Beth
Israel
Hospital
in
Boston.
He
then
spent
nineteen
years
on
the
faculty
at
Duke
University
School
of
Medicine
where
he
was
Professor
of
Pediatrics
and
Physiology
and
Director
of
the
Division
of
Pediatric
Endocrinology.
He
assumed
his
current
positions
in
Cincinnati
in
1990.
Dr.
Handwerger's
major
research
interest
is
in
the
area
of
fetal
and
perinatal
endocrinology,
with
particular
emphasis
on
the
hormonal
regulation
of
fetal
growth
and
development.
He
has
an
active
NIH
funded
research
program
to
examine
the
genetic
programs
involved
in
human
trophoblast
differentiation
and
human
uterine
decidualization.
He
is
also
the
Program
Director
of
a
NIH­
funded
training
grant
in
developmental
and
perinatal
endocrinology.
Dr.
Handwerger
has
served
previously
on
NIH
study
sections
and
was
a
member
of
the
National
Advisory
Council
of
the
National
Institute
of
Child
Health
and
Development.
He
serves
on
the
editorial
board
of
several
journals
in
endocrinology;
and
he
is
a
member
of
many
scientific
societies,
including
The
Society
for
Pediatric
Research,
The
American
Pediatric
Society,
The
American
Society
for
Clinical
Investigation,
The
American
Association
of
Physicians,
The
Endocrine
Society
and
The
Lawson
Wilkins
Pediatric
Endocrine
Society.

Kenneth
M.
Portier,
PhD
Dr.
Kenneth
M.
Portier
is
Associate
Professor
of
Statistics
and
Agricultural
Experiment
Station
Statistician
in
the
Institute
of
Food
and
Agricultural
Sciences
at
the
University
of
Florida.
A
native
of
south
Louisiana,
Dr.
Portier
received
a
BS
in
mathematics
(
1973)
from
Nicholls
State
University
(
Thibodaux,
La),
then
moved
to
the
University
of
North
Carolina
where
he
earned
a
MS
in
Statistics
(
1975)
and
a
PhD
in
Biostatistics
(
1979).
Since
early
1979,
he
has
worked
at
UF,
primarily
as
a
statistical
consultant
to
researchers
in
agriculture,
natural
resources
and
the
environment
and
as
a
Page
3
of
6
teacher
of
statistical
methods
to
graduate
students
in
associated
disciplines.
Widely
sought
after
for
graduate
committees,
Dr.
Portier
has
coauthored
publications
in
many
of
the
premier
journals
in
agriculture,
natural
resources
and
environmental
sciences.
He
has
twice
participated
in
USDA
HEP
funded
teaching
grants,
one
related
to
the
development
of
web­
based
materials
for
teaching
natural
resources
sampling
and
more
recently
for
the
development
of
a
senior
undergraduate
course
in
forested
watersheds.
In
collaboration
with
other
researchers
at
UF,
Dr.
Portier
is
Co­
PI
on
research
grants
from
NSF,
USDA,
NOAA
and
DOI.
He
collaborates
with
UF's
Center
for
Environmental
and
Human
Toxicology
primarily
answering
statistical
question
that
arise
in
environmental
sampling
and
risk
assessments.
In
recent
years,
he
has
been
a
regular
member
of
US
EPA
and
National
Toxicology
Program
science
advisory
panels
reviewing
human
and
ecological
risks
from
agriculture­
related
chemicals
and
practices.
His
research
interests
are
in
applied
statistics,
biostatistics,
statistical
computing
and
the
teaching
of
statistics.
Page
4
of
6
FQPA
SCIENCE
REVIEW
BOARD
MEMBERS
Tong­
Jen
Fu,
PhD.

Dr.
T.
J.
Fu
is
a
Research
Scientist
with
the
U.
S.
Food
and
Drug
Administration,
National
Center
for
Food
Safety
and
Technology
(
NCFST),
Summit­
Argo,
IL.
Since
joining
the
FDA
in
1992,
Dr.
Fu
has
worked
on
various
areas
of
food
safety
research
including
studies
to
determine
the
effect
of
bioprocessing
conditions
on
the
safety
of
food
ingredients
produced
by
microbial
fermentation
and
plant
tissue
culture
processes,
the
development
of
rapid
processes
for
sampling
and
detection
of
pathogens
in
fresh
produce,
as
well
as
the
evaluation
of
safety
assessment
strategies
for
genetically
engineered
foods.
Her
current
research
involves
evaluating
the
predictive
values
of
digestive
and
processing
stabilities
as
criteria
for
protein
allergenicity
assessment
as
well
as
the
effect
of
processing
on
food
allergens.
Dr.
Fu
received
her
B.
S.
degree
from
Tunghai
University,
Taiwan
and
her
M.
S.
and
Ph.
D.
degrees
from
The
Pennsylvania
State
University,
all
in
Chemical
Engineering.

Louis
B.
Hersh,
PhD.

Dr.
Louis
B.
Hersh
is
Professor
and
Chair
of
the
Department
of
Molecular
and
Cellular
Biochemistry
at
the
University
of
Kentucky
College
of
Medicine.
He
received
his
PhD
from
Brandies
University
in
Biochemistry
in
1967
and
subsequently
completed
a
postdoctoral
fellowship
at
the
National
Heart
Lung
and
Blood
Institute
at
the
NIH
in
Bethesda,
Maryland.
He
previously
served
on
the
faculty
of
the
University
of
Texas
Southwestern
Medical
School
in
Dallas.
Dr.
Hersh
has
had
a
long
standing
NIH
funded
research
program
in
the
enzymology
and
molecular
biology
of
the
cholinergic
system
and
on
peptidases
that
degrade
neuropeptides.
He
has
published
more
than
250
scientific
papers,
and
has
served
on
numerous
scientific
review
panels
for
the
NIH
and
for
the
Damon
Runyon
Foundation.

Simon
P
Hogan,
PhD.

Dr
Simon
P.
Hogan
is
Assistant
Professor
of
Pediatrics,
Division
of
Allergy
and
Immunology,
Cincinnati
Children's
Hospital
Medical
Center,
Cincinnati,
OH.
He
received
his
Ph.
D.
from
the
John
Curtin
School
of
Medical
Research,
Australian
National
University,
Canberra,
Australia
in
1998
and
subsequently
completed
a
National
Health
Medical
Research
Council
NHMRC
CJ
Martin
Fellowship
in
Allergy
and
Immunology
at
Cincinnati
Children's
Hospital
Medical
Center,
Cincinnati,
OH.
He
was
appointed
in
2004
to
Head
of
the
Gastrointestinal
Research
laboratory,
John
Curtin
School
of
Medical
Research,
ANU,
Canberra,
Australia
as
part
of
the
NHMRC
funded
Program
grant
to
examine
Molecular
mechanisms
in
the
regulation
of
allergy
and
inflammation.
Dr
Hogan
has
an
active
research
program
investigating
inflammation
induced
gastrointestinal
dysfunction.
Current
projects
are
(
1)
to
elucidate
the
cellular
and
molecular
processes
involved
in
gastrointestinal
allergic
responses
using
novel
models
of
allergic
responses
in
mice
with
translational
studies
in
humans,
(
2)
to
identify
the
role
of
gastrointestinal
Page
5
of
6
inflammation
in
peristaltic
reflex
and
gastrointestinal
epithelial
cell
dysfunction
and
(
3)
to
characterize
food
allergen
reactive
T
cells
in
eosinophilic
esophagitis.

Dean
Metcalfe
M.
D.

Dr.
Metcalfe
received
his
undergraduate
degree
from
Northern
Arizona
University,
his
M.
D.
from
the
University
of
Tennessee,
and
his
training
in
Internal
Medicine
at
the
University
of
Michigan.
Dr.
Metcalfe
was
a
Fellow
in
Allergy
and
Immunology
at
NIH
and
a
Fellow
in
Rheumatology
and
Immunology
at
the
Robert
Brigham
Hospital
and
the
Harvard
Medical
School.
In
1979,
he
returned
to
NIH
as
a
Senior
Clinical
Investigator.
His
subsequent
career
has
been
devoted
to
research
and
public
service
at
the
NIH.
There
he
combines
clinical
and
basic
research,
patient
care
and
administrative
duties,
as
well
as
scholarly
activity
in
the
form
of
teaching,
writing,
and
speaking
in
public
on
areas
related
to
allergic
diseases.
In
1995,
Dr.
Metcalfe
was
appointed
the
first
Chief
of
the
newly
created
Laboratory
of
Allergic
Diseases,
NIAID.
He
is
also
Director
of
the
NIH
Clinical
Center
Pediatric
and
Internal
Medicine
Allergy
and
Immunology
Training
Program.
Dr.
Metcalfe
is
an
author
on
over
400
scientific
publications
on
mast
cell
biology,
food
allergy,
mastocytosis,
and
asthma.
He
is
a
past
Chairman
of
the
American
Board
of
Allergy
and
Immunology,
a
past
President
of
the
American
Academy
of
Allergy,
Asthma,
and
Immunology
and
a
past
Chairman
of
the
ACGME­
RRC
for
Allergy
and
Immunology.
Dr.
Metcalfe
has
been
elected
to
membership
in
the
American
Society
for
Clinical
Investigation,
the
American
Association
of
Physicians
and
the
American
Clinical
and
Climatological
Association.

Shridhar
K.
Sathe,
PhD.

Dr.
Shridhar
Sathe
is
professor
of
food
science
at
Florida
State
University.
He
received
his
Ph.
D.
from
the
Utah
State
University,
Department
of
Nutrition
and
Food
Science
in
1982,
and
was
a
American
Heart
Association
(
Arizona
Affiliate)
post­
doctoral
fellow
(
1981­
1983)
and
post­
doctoral
research
associate
(
1984­
1985)
at
the
University
of
Arizona,
Tucson,
Arizona.
He
was
post­
doctoral
research
associate
(
1986­
1987)
at
Purdue
University,
West
Lafayette,
Indiana.
Dr.
Sathe
has
been
at
Florida
State
University
since
1988
as
Assistant
(
1988­
1991),
Associate
(
1991­
1996),
and
Professor
(
1997­
to
date).
He
was
selected
to
be
a
Named
Professor
in
2002.
Dr.
Sathe
has
an
active
research
program
to
identify
tree
nut­
allergenic
proteins,
to
develop
antibody
based
enzyme
linked
immunosorbent
assays
(
ELISAs)
for
their
detection
and
quantification,
and
to
identify
and
characterize
epitopes
in
tree
nut
allergenic
proteins.
His
teaching
responsibilities
at
Florida
State
University
include
teaching
food
science
at
undergraduate
and
graduate
courses.
He
has
received
several
awards
for
his
teaching
and
advising
at
Florida
State
University.
Dr.
Sathe
has
served
on
USDA
NRICGP
review
panels,
several
national
committees
of
the
Institute
of
Food
Technologists
(
IFT),
and
is
a
frequently
sought
reviewer
by
many
scientific
journals
in
food
science
and
technology
and
publishing
companies.
He
is
an
elected
fellow
of
the
IFT.
He
currently
serves
on
the
editorial
boards
of
Journal
of
Agriculture
and
Food
Chemistry,
Journal
of
Food
Biochemistry,
LWT­
Food
Science
and
Technology,
Plant
Foods
for
Human
Nutrition,
and
Korean
Food
Science
and
Biotechnology.
Page
6
of
6
Santiago
Schnell,
PhD.

Dr.
Santiago
Schnell
is
Associate
Director
of
Biocomplexity
Institute
and
Assistant
Professor
of
Informatics
with
adjunct
positions
in
Biology
and
Physics
in
Indiana
University
(
Bloomington).
Dr.
Schnell
received
his
License
in
Biology
(
with
special
emphasis
on
biochemistry
and
molecular
biology)
and
D.
Phil.
in
Applied
Mathematics
from
Universidad
Simón
Bolívar
(
Venezuela)
and
University
of
Oxford
(
United
Kingdom),
respectively.
He
has
just
left
a
position
in
the
Centre
for
Mathematical
Biology
at
the
Mathematical
Institute
of
the
University
of
Oxford.
He
held
the
posts
of
Ordinary
Fellow
of
the
Wellcome
Trust
(
London)
and
Junior
Research
Fellow
of
Christ
Church
(
Oxford).
He
was
the
José
Gregorio
Hernández
Research
Fellow
of
the
Venezuelan
Academy
of
Medicine,
the
Lord
Miles
Senior
Scholar
in
Science
of
Pembroke
College
(
Oxford)
and
Lecturer
in
Applied
Mathematics
for
Pembroke
and
Brasenose
College
(
Oxford).
He
also
is
a
founding
member
of
the
Bioethical
Committee
of
the
Venezuelan
National
Council
of
Science.
Dr.
Schnell
has
an
active
research
program
in
theoretical
and
mathematical
biology
focused
in
three
areas:
theoretical
enzyme
kinetics,
the
dynamics
of
complex
biochemical
reactions,
and
the
study
of
segmentation
mechanisms
in
early
embryogenesis.

Rami
Tzafriri,
PhD.

Dr.
Tzafriri
is
a
postdoctoral
fellow
at
the
Harvard­
MIT
Biomedical
Engineering
Center.
He
received
his
Ph.
D.
from
the
Hebrew
University
of
Jerusalem
School
of
Computer
Science
and
Engineering
in
2002.
Dr.
Tzafriri's
expertise
is
in
modeling
cellular
and
tissue
pharmacokinetics
and
enzyme
kinetics.
His
Ph.
D.
thesis
focused
on
mathematical
modeling
of
biodegradable
drug
delivery
devices
and
included
the
analysis
of
mechanisms
leading
to
burst
releases
from
bulk
degrading
polymer
matrices,
the
derivation
of
the
first
mechanistic
model
of
enzymatic
degradation
of
insoluble
collagen
matrices
and
the
extension
of
the
Michaelis
Menten
approximation
to
high
enzymesubstrate
ratios.
Dr.
Tzafriri's
postdoctoral
research
is
focused
on
in
silico
modeling
if
therapeutic
angiogenesis
and
the
analysis
of
cellular
trafficking
of
growth
factors.
He
is
a
member
of
the
Biophysical
Society,
the
Society
of
Applied
and
Industrial
Mathematics
and
the
Society
of
Mathematical
Biology
and
is
a
recipient
of
a
Philip
Morris
External
Research
Postdoctoral
Fellowship.