Document ID: EPA-HQ-OPP-2009-0823-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2011-03-02T05:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

 

OFFICE OF              

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES 

MEMORANDUM

Date:		21-Jan-2010

Subject:	Difenoconazole.  Acute and Chronic Aggregate Dietary Exposure
and Risk Assessments for the Section 3 Registration Request for Mango
and Wax Apple. 

				

PC Code:  	128847	DP Barcode:	371613

Decision No.: 413927	Registration No.:  None

Petition Nos.:  9E7573 	Regulatory Action:  Section 3

Assessment Type:  Single Chemical, Dietary 	Registration Case No.:  NA

TXR No.:  None	CAS No.:  119446-68-3

MRID No.:  None	40 CFR: 180.475

Reviewer:	Thurston G. Morton, Chemist

Risk Assessment Branch IV/Health Effects Division (RABIV/HED; 7509P)

Through:	Doug Dotson, PhD., Chemist

Julie Van Alstine, MPH, Environmental Health Scientist

Dietary Exposure Science Advisory Council (DESAC)

	And

Susan V. Hummel, Senior Chemist

RABIV/HED (7509P)

To:			Yan Donovan, Risk Assessor

RABIV/HED (7509P)

	And

Tony Kish

Fungicide Branch/RD (7505P)

Executive Summary

Aggregate (food + water) acute and chronic dietary risk assessments were
conducted using the Dietary Exposure Evaluation Model - Food Consumption
Intake Database (DEEM-FCID(, ver. 2.03).  This model uses food
consumption data from the United States Department of Agriculture’s
(USDA’s) Continuing Surveys of Food Intakes by Individuals (CSFII;
1994-1996 and 1998).  The analyses were performed to support a Section 3
request for new uses of the fungicide difenoconazole
[1-[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-ylmet
hyl]-1H-1,2,4-triazole] in/on mango and wax apple.  

The unrefined acute analysis assumed tolerance-level residues, 100% crop
treated (CT), and the available empirical or DEEM( (ver. 7.81) default
processing factors.  The resulting acute food exposure estimates were
less than HED’s level of concern (<100% of the acute
population-adjusted dose (aPAD)) at the 95th percentile of the exposure
distribution for the general U.S. population (7 % aPAD) and all
population sub-groups; the most highly exposed population subgroup was
children1-2 years old with 16 % aPAD.  The somewhat refined chronic
analysis assumed tolerance-level residues for some commodities, average
field trial residues for the majority of commodities, the available
empirical or DEEM( (ver. 7.81) default processing factors, and 100 % CT.
 The resulting chronic food exposure estimates were less than HED’s
level of concern (<100% of the chronic population-adjusted dose (cPAD))
for the general U.S. population (17 % cPAD) and all population
sub-groups; the most highly exposed population subgroup was children 1-2
years old with 45 % cPAD.  

The requested uses of difenoconazole did not result in an increase in
dietary exposure estimates for free triazole or conjugated triazoles. 
Therefore, the last dietary exposure analyses for the triazole
metabolites (M. Negussie, 28 Oct. 2009) have not changed.

I.   Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the PAD.  The PAD is equivalent
to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the
required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  HED is generally
concerned when estimated cancer risk exceeds one in one million. 
References which discuss the acute and chronic risk assessments in more
detail are available on the EPA/pesticides web site:  “Available
Information on Assessing Exposure from Pesticides, A User’s Guide,”
21-JUN-2000, web link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see
SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for difenoconazole was conducted
by T. Morton (22-September-2009; DP#367383).

II.   Residue Information

Difenoconazole tolerances are published in 40 CFR§180.475.

Residues of Concern in Plants and Livestock:   The HED Metabolism
Assessment Review Committee (MARC) has determined that for tolerance
expression and risk assessment purposes, the residue of concern is
difenoconazole per se for plant and livestock commodities.  The MARC,
however, stated that if tolerances are proposed for difenoconazole
resulting from foliar uses which result in higher residue levels of
CGA-205375 than parent, then the need to include CGA-205375 should be
reconsidered (Memo, G. Kramer, 22-JUL-1994; No DP#).  Because the
petitioner has now proposed foliar uses of difenoconazole, which result
in higher residues in crop commodities, the need to include metabolite
CGA 205375 in the tolerance expression and/or risk assessment has been
re-examined.  Based upon a review of the previously-submitted metabolism
data for difenoconazole, HED concludes the residue of concern for both
tolerance setting and risk assessment for the crops included in this
petition is difenoconazole.  However, HED concludes the residue of
concern in livestock for tolerance setting and risk assessment are
difenoconazole and its metabolite CGA 205375 (for more details, see the
summary document, DP# 340379).  Table 1 below summarizes tolerance
expression and the residues of concern in plant and livestock
commodities.  

Table 1.  Difenoconazole Residues of Concern in Plants and Ruminants.

Matrix	

Residues of Concern

	

For Risk Assessment	

For Tolerance Expression

Plants	Primary and Rotational crops	

Parent Only	

Parent Only

Livestock	Ruminant and Poultry	

Parent and CGA 205375	

Parent and CGA 205375

Drinking Water	

Parent Only	

NA

Recommended Tolerances:  Based on the residue chemistry data submitted
with the current petitions, HED recommended for establishment of the new
food tolerances (DP# 366507, B. Cropp-Kohlligian, 21-Jan-2010).  The
recommended, established, and revised tolerances are listed in Table 2
below.

Table 2.  Tolerance Summary for Difenoconazole.

Commodity	Existing/Established Tolerances (ppm)	New Recommended
Tolerances (ppm)

Almond, nutmeat1	0.05	0.03 tree nut

Almond, hulls1	5.0	7.0

Brassica subgroup 5A	none	1.9

Brassica subgroup 5B	none	35

Citrus, dried pulp	none	2.5

Citrus oil	none	25

Fruit, citrus, group 10	none	0.6

Grape	0.1	4.0

Grape, raisin	none	6.0

Nut, tree, group 14	none	0.03

Onion, bulb, subgroup 3—07A	none	0.20

Onion, green, subgroup 3—07B	none	6.0

Pistachios	none	0.03

Vegetable, cucurbit, group 91	1.0 individual RACs	0.7

Fruit, Pome, group 11	1.0	------

Vegetable, Fruiting, Group 8	0.60	------

Vegetable, Tuberous and Corm, subgroup 1C	0.01	------

Beet, sugar2	0.30	------

Papaya	0.30	------

Apple, wet pomace	4.5	------

Beet, sugar, dried pulp	1.9	------

Potato, processed waste	0.04	------

Banana	0.2	------

Barley, grain	0.1	------

Barley, hay	0.05	------

Barley, straw	0.05	------

Canola, seed	0.01	------

Cattle fat	0.10	------

Cattle, meat	0.05	------

Cattle, meat byproducts	0.10	------

Cattle, liver	0.20	------

Corn, sweet, forage	0.01	------

Corn, sweet, kernel plus cob with husks removed	0.01	------

Corn, sweet, stover	0.01	------

Cotton, gin byproducts	0.05	------

Cotton, undelinted seed	0.05	------

Egg3	0.10	------

Goat, fat	0.10	------

Goat, meat	0.05	------

Goat, meat byproducts (except liver)	0.10	------

Goat, liver	0.20	------

Hog, fat	0.10	------

Hog, meat	0.05	------

Hog, meat byproducts (except liver)	0.1	------

Hog, liver	0.20	------

Horse, fat	0.10	------

Horse, meat	0.05	------

Horse, meat byproducts (except liver)	0.10	------

Horse, liver	0.20	------

Milk	0.01	------

Rye, grain	0.1	------

Sheep, fat	0.10	------

Sheep, meat	0.05	------

Sheep, meat byproducts (except liver)	0.10	------

Sheep, liver	0.20	------

Wheat, forage	0.1	------

Wheat, grain	0.1	------

Wheat, straw	0.1	------

Wax apple	None	0.07

Mango	None	0.07

1 Section 18 emergency exemption tolerance. 

2 The registered tolerance on sugar beet (0.01 ppm) needs to be changed
to 0.3 ppm; see “Notes to RD” in memorandum: M. Sahafeyan, D351715,
07-MAY-08.

3 Based on a feeding study, HED recommended the tolerances for poultry
commodities (except egg) be removed and the egg tolerance be increased
to the current level of 0.1 ppm.

The requested uses of difenoconazole did not result in an increase in
dietary exposure estimates for free triazole or conjugated triazoles. 
Therefore, the last dietary exposure analyses for the triazole
metabolites (M. Negussie, 28 Oct. 2009) have not changed.

Food Residues and processing factors used in the Acute and Chronic
Analysis:  The acute analysis assumed tolerance-level residues and 100%
CT for all the registered and proposed crops.  Tolerance-level residues
were also assumed for all livestock tissues in this assessment.  The
chronic analysis assumed tolerance-level residues for some commodities,
average field trial residues for the majority of commodities, and 100 %
CT.  Those commodities where field trial data were used are summarized
below.  HED SOP 2000.1 Guidance for Translation of Field Trial Data from
Representative Commodities in the Crop Group Regulation to Other
Commodities in Each Crop Group/Subgroup dated 9/12/2000 was used in
translating to other commodities in the crop group.  Experimental
processing factors were used for apple juice (0.04x), grape juice
(0.2x), citrus juices (0.1x), potato chips (0.5x), potato
granules/flakes (0.5x), raisin (3.5x chronic only), sugar beet molasses
(0.6x), tomato paste (1.6x), and tomato puree (0.5x); DEEM( (ver. 7.81)
default processing factors were assumed for other processed commodities.
 

No free triazole or conjugated triazole residue data were submitted with
the mango residue field trial submission.  However, current dietary
exposure estimates  are conservative enough that submission of this
residue data on mango is not expected to result in an increase in
aggregate exposure.

Almond: Field trial residues were used from MRID 47586101.  

Apple: Field trial residues were used from MRID 46950233.

Broccoli: Field trial residues were used from MRID 47586102.  Residues
from 1-7 day PHI were used since registered labels allow from 1-7 day
PHIs.

Cabbage:  Field trial residues were used from 47586102.  Residues from
1-7 day PHI were used since registered labels allow from 1-7 day PHIs. 
To refine the dietary exposure data from only cabbage samples without
wrapper leaves were used.

Cantaloupe: Field trial residues were used from MRID 47586103.  Residues
from 0-1 day PHI were used since registered labels allow from 0-1 day
PHI.

Cucumber: Field trial residues were used from MRID 47586103.  Residues
from 0-1 day PHI were used since registered labels allow from 0-1 day
PHI.

Grape: Field trial residues were used from MRID 47586105.

Grapefruit: Field trial residues were used from MRID 47586104.

Leaf Lettuce: Field trial residues were used from MRIDs 47417703 and
47417706.

Lemon: Field trial residues were used from MRID 47586104.

Lime: Field trial residues were used from MRID 47586104.

Mustard Greens: Field trial residues were used from MRIDs 47417704,
47417707, and 47586102.  Residues from 1-7 day PHI were used since
registered labels allow from 1-7 day PHIs.

Orange: Field trial residues were used from MRID 47586104.

Pear: Field trial residues were used from MRID 46950233.

Pecan: Field trial residues were used from MRID 47586106.

Peppers: Field trial residues were used from MRID 46950234.

Potato: Field trial residues were used from MRID 46950235.

Sugar Beet: Field trial residues were used from MRID 46950236.

Summer Squash: Field trial residues were used from MRID 47586103. 
Residues from 0-1 day PHI were used since registered labels allow from
0-1 day PHIs.

Tomato: Field trial residues were used from MRIDs 46950234, 47417705,
and 47417708.

  Drinking Water Data

The drinking water estimates used in the dietary risk assessment were
provided by the Environmental Fate and Effects Division (EFED; Memo, I.
Maher, 28-MAY-2009; D361398).  EFED conducted a Tier II drinking water
assessment for surface water sources using the Pesticide Root
Zone/Exposure Analysis Modeling System (PRZM/EXAMS) for the registered
and proposed new uses.  Among all the registered and proposed new uses,
the highest estimated drinking water concentrations (EDWCs) for surface
water sources were derived for aerial applications of difenoconazole to
New York grapes at the maximum annual application rate of 0.46 lb
ai/acre. The estimated drinking water residues for 1-in-10 year annual
peak, 1-in-10 year annual mean, and 36-year annual mean are 15.8, 10.4,
and 7.62 μg/L (ppb) respectively.  

μg/L (ppb)  was used for the acute dietary exposure analysis and the
1-in-10 year annual mean EDWC of 10.4 μg/L (ppb) was used for the
chronic dietary exposure analysis.

IV.   DEEM-FCID( Program and Consumption Information

Difenoconazole acute and chronic dietary exposure assessments were
conducted using the DEEM-FCID( (ver. 2.03), which incorporates
consumption data from USDA’s CSFII (1994-1996 and 1998).  The 1994-96,
98 data are based on the reported consumption of more than 20,000
individuals over two non-consecutive survey days.  Foods “as
consumed” (e.g., apple pie) are linked to EPA-defined food commodities
(e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat
flour - cooked; fresh or N/S, baked) using publicly available recipe
translation files developed jointly by USDA/ARS and EPA.  For chronic
exposure assessment, consumption data are averaged for the entire U.S.
population and within population subgroups, but for acute exposure
assessment are retained as individual consumption events.  Based on
analysis of the 1994-96, 98 CSFII consumption data, which took into
account dietary patterns and survey respondents, HED concluded that it
is most appropriate to report risk for the following population
subgroups:  the general U.S. population, all infants (<1 year old),
children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49,
females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form.  The resulting residue
consumption estimate for each food/food form is summed with the residue
consumption estimates for all other food/food forms on the commodity
residue list to arrive at the total average estimated exposure. 
Exposure is expressed in mg/kg body weight/day and as a percent of the
cPAD.  This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., those who reported eating
relevant commodities/food forms) and a per-capita (i.e., those who
reported eating the relevant commodities as well as those who did not)
basis.  In accordance with HED policy, per capita exposure and risk are
reported for all tiers of analysis.  However, for Tiers 1 and 2,
significant differences in user vs. per capita exposure and risk are
identified and noted in the risk assessment.

V.   Toxicological Information

On 08-SEP-1998, HED’s Hazard Identification Assessment Review
Committee (HIARC) evaluated the toxicology database of difenoconazole
and re-assessed the RfD established in 1994, as well as the
toxicological endpoints for the dietary and occupational exposure risk
assessments that were selected in 1994.  At this meeting, the HIARC also
addressed the potential enhanced sensitivity of infants and children
from exposure to difenoconazole as required by the Food Quality
Protection Act (FQPA) of 1996 (HED Doc. No. 012873, 25-SEP-1998).  In
July, 2007, the RAB1 toxicologists and risk assessment team met to
reevaluate the endpoints selected by the HIARC since new studies were
submitted.  RAB1 toxicologists and risk assessment team also reevaluated
FQPA assessments.  The risk assessment team concluded that the default
10x FQPA Safety Factor (SF) should be reduced to 1x when assessing acute
and chronic dietary exposures (M.Sahafeyan, D333320, 09-AUG-07).  The
relevant endpoints are shown in Table 3.

For purposes of this action, HED recently reviewed HED’s 27-JUL-1994
Cancer Peer Review Committee (CPRC) report (Memo, Jess Rowland and
Esther Rinde) on difenoconazole and the supporting data-evaluation
records (DERs).  HED concluded that difenoconazole is a very weak
carcinogen, showing effects only at excessive doses.  In retrospect, the
CPRC should have classified this pesticide as a category C with no
linear quantification of cancer risk.  The cRfD, based on borderline
liver effects in male rats at 24.1 mg/kg and a NOAEL of 0.96 mg/kg, is
protective of any carcinogenic effects seen in the mouse (Memo, S. Levy
et al., 05-AUG-2005; DP# 319944).  Therefore, a separate cancer dietary
assessment is not being conducted for difenoconazole.

Table 3.  Summary of Toxicological Doses and Endpoints for
Difenoconazole for Use in Dietary Risk Assessments.  

Exposure Scenario	Point of Departure	Uncertainty/FQPA Safety Factors
RfD, PAD, for Risk Assessment	Study and Relevant Toxicological Effects

Acute Dietary (All populations)	NOAEL = 25

mg/kg	UFA = 10X

UFH = 10X

FQPA SF = 1X 	aRfD = aPAD = 0.25 mg/kg/day	Acute Neurotoxicity Study in
Rats

LOAEL= 200 mg/kg in males based on reduced fore-limb grip strength in
males on day 1.

Chronic Dietary (All populations)	NOAEL = 0.96

mg/kg/day	UFA = 10X

UFH = 10X

FQPA SF = 1X	cRfD = cPAD = 0.01mg/kg/day	Combined chronic
toxicity/carcinogenicity (rat; dietary) LOAEL = 24.1/32.8 mg/kg/day
(M/F) based on cumulative decreases in body-weight gains.

Cancer (oral, dermal, inhalation)	Difenoconazole is classified as a
Group C, possible human carcinogen with a non-linear (MOE) approach for
human risk characterization (CPRC Document, 7/27/94, Memo, P. V. Shah
dated March 3, 2007, HED Doc. No. 0054532). The chronic dietary exposure
assessment is protective of cancer effects.

Point of Departure (POD) = A data point or an estimated point that is
derived from observed dose-response data and  used to mark the beginning
of extrapolation to determine risk associated with lower environmentally
relevant human exposures.  NOAEL = no observed adverse effect level. 
LOAEL = lowest observed adverse effect level.  UF = uncertainty factor. 
UFA = extrapolation from animal to human (interspecies).  UFH =
potential variation in sensitivity among members of the human population
(intraspecies).  FQPA SF = FQPA Safety Factor.  PAD = population
adjusted dose (a = acute, c = chronic).  RfD = reference dose.   

VI.   Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned
when dietary risk exceeds 100% of the aPAD or cPAD, respectively.  The
following paragraphs are summaries of the DEEM-FCID( (ver. 2.03) acute
and chronic exposure analyses.

Acute and chronic aggregate (food + water) analyses were performed using
DEEM-FCID( estimating the dietary exposure of the U.S. population and
various population subgroups.  The results are summarized in Tables 4
and 5 below for acute and chronic analyses respectively.  

The resulting acute food exposure estimates were less than HED’s level
of concern (<100% aPAD) at the 95th percentile of the exposure
distribution for general US population (7 % aPAD) and all population
sub-groups; the most highly exposed population subgroup was Children 1-2
years old with 16 % aPAD.  The resulting chronic food exposure estimates
were less than HED’s level of concern (<100% cPAD) for the general
U.S. population (17 % cPAD) and all population sub-groups; the most
highly exposed population subgroup was children 1-2 years old with 45 %
cPAD.   A cancer dietary assessment was not conducted for difenoconazole
because the cancer NOAEL is higher than the chronic RfD; therefore, the
chronic dietary risk estimate is more protective.

Table 4.  Summary of Acute Dietary Exposure and Risk for Difenoconazole
at the 95th Percentile. 

Population Subgroup	

aPAD (mg/kg/day)	

Exposure (mg/kg/day)	

%aPAD

General U.S. Population	

0.25	

0.017747	7

All Infants (< 1 year old)

0.0255139	10

Children 1-2 years old

0.039565	16

Children 3-5 years old

0.031818	13

Children 6-12 years old

0.017949	7

Youth 13-19 years old

0.008828	4

Adults 20-49 years old 

0.013083	5

Adults 50+ years old 

0.017255	7

Females 13-49 years old 

0.013281	5

The bolded %aPAD is the highest.

Table 5.  Summary of Chronic Dietary Exposure and Risk for
Difenoconazole. 

Population Subgroup	

cPAD (mg/kg/day)	

Exposure (mg/kg/day)	

%cPAD

General U.S. Population	

0.01	

0.001709	17

All Infants (< 1 year old)

0.002445	25

Children 1-2 years old

0.004484	45

Children 3-5 years old

0.003624	36

Children 6-12 years old

0.002061	21

Youth 13-19 years old

0.001372	14

Adults 20-49 years old 

0.001376	14

Adults 50+ years old 

0.001548	16

Females 13-49 years old 

0.001402	14

The bolded %cPAD is the highest.

  

VII.   Characterization of Inputs/Outputs

The acute analysis assumed tolerance-level residues, 100% CT, and
empirical or DEEM( default processing factors.  The chronic analysis
assumed tolerance-level residues for some commodities, average field
trial residues for the majority of commodities, 100 % CT, and empirical
or DEEM( default processing factors.  Therefore, these analyses are
considered conservative.  They do not warrant the need for further
refinement at this time.

VIII.   Conclusions

An acute aggregate (food + water) dietary risk assessment was conducted
for difenoconazole using the DEEM-FCID( (ver. 2.03) Model and assumed
tolerance-level residues, 100% CT, and empirical or DEEM( default
processing factors.  The chronic aggregate dietary risk assessment
assumed tolerance-level residues for some commodities, average field
trial residues for the majority of commodities, 100 % CT, and empirical
or DEEM( default processing factors.  The resulting acute and chronic
aggregate exposure estimates were less than HED’s level of concern. 
For the general U.S. population, the aPAD and cPAD were 7 % and 17 %,
respectively.  The most highly-exposed population subgroups in the acute
(at the 95th percentile of the exposure distribution) and chronic
analyses were Children 1-2 years old (16 % aPAD) and children 1-2 years
old (45 % cPAD), respectively.  

IX.   Attachments

Attachment 1:	DEEM-FCID( Acute Residue File

Attachment 2:	DEEM-FCID( Acute Exposure Estimates

Attachment 3:	DEEM-FCID( Chronic Residue File

Attachment 4:	DEEM-FCID( Chronic Exposure Estimates

cc with all attachments:  T. Morton (RABIV)

RDI: D. Dotson and J.Van Alstine - DESAC (7-Jan-2010); S. Hummel
(21-Jan-2010)

Petition Number(s): PP#8F7482

DP#: 371613

PC Code: 128847

T. Morton:S10922:PY1:(703)305-6691

Attachment 1:  DEEM-FCID( Acute Residue File

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM
Files\128847 DifenocozoleNew Uses of Wax Apple and
Mango\difenoconazole_acute-01-10.R98

Chemical: Difenoconazole

RfD(Chronic): .01 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .25 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 01-12-2010/10:30:55/8          Program ver.
2.03

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

95000230 O    Banana                             0.200000   1.000  1.000
 

95000231 O    Banana-babyfood                    0.200000   1.000  1.000
 

95000240 O    Banana, dried                      0.200000   3.900  1.000
 

95000241 O    Banana, dried-babyfood             0.200000   3.900  1.000
 

95001280 O    Cottonseed, oil                    0.050000   1.000  1.000
 

95001281 O    Cottonseed, oil-babyfood           0.050000   1.000  1.000
 

95001750 O    Grape                              4.000000   1.000  1.000
 

95001760 O    Grape, juice                       4.000000   0.200  1.000
 

95001761 O    Grape, juice-babyfood              4.000000   0.200  1.000
 

95001770 O    Grape, leaves                      4.000000   1.000  1.000
 

95001780 O    Grape, raisin                      6.000000   1.000  1.000
 

95001790 O    Grape, wine and sherry             4.000000   1.000  1.000
 

95002150 O    Mango                              0.070000   1.000  1.000
 

95002151 O    Mango-babyfood                     0.070000   1.000  1.000
 

95002160 O    Mango, dried                       0.070000   1.000  1.000
 

95002170 O    Mango, juice                       0.070000   1.000  1.000
 

95002171 O    Mango, juice-babyfood              0.070000   1.000  1.000
 

95002450 O    Papaya                             0.300000   1.000  1.000
 

95002451 O    Papaya-babyfood                    0.300000   1.000  1.000
 

95002460 O    Papaya, dried                      0.300000   1.800  1.000
 

95002470 O    Papaya, juice                      0.300000   1.500  1.000
 

95002830 O    Plantain                           0.200000   1.000  1.000
 

95002840 O    Plantain, dried                    0.200000   3.900  1.000
 

86010000 O    Water, direct, all sources         0.015800   1.000  1.000
 

86020000 O    Water, indirect, all sources       0.015800   1.000  1.000
 

21000440 M    Beef, meat                         0.050000   1.000  1.000
 

21000441 M    Beef, meat-babyfood                0.050000   1.000  1.000
 

21000450 M    Beef, meat, dried                  0.050000   1.920  1.000
 

21000460 M    Beef, meat byproducts              0.100000   1.000  1.000
 

21000461 M    Beef, meat byproducts-babyfood     0.100000   1.000  1.000
 

21000470 M    Beef, fat                          0.100000   1.000  1.000
 

21000471 M    Beef,fat-babyfood                  0.100000   1.000  1.000
 

21000480 M    Beef, kidney                       0.100000   1.000  1.000
 

21000490 M    Beef, liver                        0.200000   1.000  1.000
 

21000491 M    Beef, liver-babyfood               0.200000   1.000  1.000
 

23001690 M    Goat, meat                         0.050000   1.000  1.000
 

23001700 M    Goat, meat byproducts              0.100000   1.000  1.000
 

23001710 M    Goat, fat                          0.100000   1.000  1.000
 

23001720 M    Goat, kidney                       0.100000   1.000  1.000
 

23001730 M    Goat, liver                        0.200000   1.000  1.000
 

24001890 M    Horse, meat                        0.050000   1.000  1.000
 

25002900 M    Pork, meat                         0.050000   1.000  1.000
 

25002901 M    Pork, meat-babyfood                0.050000   1.000  1.000
 

25002910 M    Pork, skin                         0.100000   1.000  1.000
 

25002920 M    Pork, meat byproducts              0.100000   1.000  1.000
 

25002921 M    Pork, meat byproducts-babyfood     0.100000   1.000  1.000
 

25002930 M    Pork, fat                          0.100000   1.000  1.000
 

25002931 M    Pork, fat-babyfood                 0.100000   1.000  1.000
 

25002940 M    Pork, kidney                       0.100000   1.000  1.000
 

25002950 M    Pork, liver                        0.200000   1.000  1.000
 

26003390 M    Sheep, meat                        0.050000   1.000  1.000
 

26003391 M    Sheep, meat-babyfood               0.050000   1.000  1.000
 

26003400 M    Sheep, meat byproducts             0.100000   1.000  1.000
 

26003410 M    Sheep, fat                         0.100000   1.000  1.000
 

26003411 M    Sheep, fat-babyfood                0.100000   1.000  1.000
 

26003420 M    Sheep, kidney                      0.100000   1.000  1.000
 

26003430 M    Sheep, liver                       0.200000   1.000  1.000
 

70001450 P    Egg, whole                         0.100000   1.000  1.000
 

70001451 P    Egg, whole-babyfood                0.100000   1.000  1.000
 

70001460 P    Egg, white                         0.100000   1.000  1.000
 

70001461 P    Egg, white (solids)-babyfood       0.100000   1.000  1.000
 

70001470 P    Egg, yolk                          0.100000   1.000  1.000
 

70001471 P    Egg, yolk-babyfood                 0.100000   1.000  1.000
 

27002220 D    Milk, fat                          0.010000   1.000  1.000
 

27002221 D    Milk, fat - baby food/infant for   0.010000   1.000  1.000
 

27012230 D    Milk, nonfat solids                0.010000   1.000  1.000
 

27012231 D    Milk, nonfat solids-baby food/in   0.010000   1.000  1.000
 

27022240 D    Milk, water                        0.010000   1.000  1.000
 

27022241 D    Milk, water-babyfood/infant form   0.010000   1.000  1.000
 

27032251 D    Milk, sugar (lactose)-baby food/   0.010000   1.000  1.000
 

01010520 1A   Beet, sugar                        0.300000   1.000  1.000
 

01010521 1A   Beet, sugar-babyfood               0.300000   1.000  1.000
 

01010530 1A   Beet, sugar, molasses              0.300000   0.600  1.000
 

01010531 1A   Beet, sugar, molasses-babyfood     0.300000   0.600  1.000
 

01032960 1C   Potato, chips                      0.010000   0.500  1.000
 

01032970 1C   Potato, dry (granules/ flakes)     0.010000   0.500  1.000
 

01032971 1C   Potato, dry (granules/ flakes)-b   0.010000   0.500  1.000
 

01032980 1C   Potato, flour                      0.010000   0.500  1.000
 

01032981 1C   Potato, flour-babyfood             0.010000   0.500  1.000
 

01032990 1C   Potato, tuber, w/peel              0.010000   1.000  1.000
 

01032991 1C   Potato, tuber, w/peel-babyfood     0.010000   1.000  1.000
 

01033000 1C   Potato, tuber, w/o peel            0.010000   1.000  1.000
 

01033001 1C   Potato, tuber, w/o peel-babyfood   0.010000   1.000  1.000
 

03001640 3    Garlic                             0.200000   1.000  1.000
 

03001650 3    Garlic, dried                      0.200000   1.000  1.000
 

03001651 3    Garlic, dried-babyfood             0.200000   1.000  1.000
 

03001980 3    Leek                               6.000000   1.000  1.000
 

03002370 3    Onion, dry bulb                    0.200000   1.000  1.000
 

03002371 3    Onion, dry bulb-babyfood           0.200000   1.000  1.000
 

03002380 3    Onion, dry bulb, dried             0.200000   9.000  1.000
 

03002381 3    Onion, dry bulb, dried-babyfood    0.200000   9.000  1.000
 

03002390 3    Onion, green                       6.000000   1.000  1.000
 

03003380 3    Shallot                            0.200000   1.000  1.000
 

05010610 5A   Broccoli                           1.900000   1.000  1.000
 

05010611 5A   Broccoli-babyfood                  1.900000   1.000  1.000
 

05010620 5A   Broccoli, Chinese                  1.900000   1.000  1.000
 

05020630 5B   Broccoli raab                     35.000000   1.000  1.000
 

05010640 5A   Brussels sprouts                   1.900000   1.000  1.000
 

05010690 5A   Cabbage                            1.900000   1.000  1.000
 

05020700 5B   Cabbage, Chinese, bok choy        35.000000   1.000  1.000
 

05010710 5A   Cabbage, Chinese, napa             1.900000   1.000  1.000
 

05010720 5A   Cabbage, Chinese, mustard          1.900000   1.000  1.000
 

05010830 5A   Cauliflower                        1.900000   1.000  1.000
 

05021170 5B   Collards                          35.000000   1.000  1.000
 

05021940 5B   Kale                              35.000000   1.000  1.000
 

05011960 5A   Kohlrabi                           1.900000   1.000  1.000
 

05022290 5B   Mustard greens                    35.000000   1.000  1.000
 

05023180 5B   Rape greens                       35.000000   1.000  1.000
 

05023890 5B   Turnip, greens                    35.000000   1.000  1.000
 

08001480 8    Eggplant                           0.600000   1.000  1.000
 

08002340 8    Okra                               0.600000   1.000  1.000
 

08002700 8    Pepper, bell                       0.600000   1.000  1.000
 

08002701 8    Pepper, bell-babyfood              0.600000   1.000  1.000
 

08002710 8    Pepper, bell, dried                0.600000   1.000  1.000
 

08002711 8    Pepper, bell, dried-babyfood       0.600000   1.000  1.000
 

08002720 8    Pepper, nonbell                    0.600000   1.000  1.000
 

08002721 8    Pepper, nonbell-babyfood           0.600000   1.000  1.000
 

08002730 8    Pepper, nonbell, dried             0.600000   1.000  1.000
 

08003740 8    Tomatillo                          0.600000   1.000  1.000
 

08003750 8    Tomato                             0.600000   1.000  1.000
 

08003751 8    Tomato-babyfood                    0.600000   1.000  1.000
 

08003760 8    Tomato, paste                      0.600000   1.600  1.000
 

08003761 8    Tomato, paste-babyfood             0.600000   1.600  1.000
 

08003770 8    Tomato, puree                      0.600000   0.500  1.000
 

08003771 8    Tomato, puree-babyfood             0.600000   0.500  1.000
 

08003780 8    Tomato, dried                      0.600000  14.300  1.000
 

08003781 8    Tomato, dried-babyfood             0.600000  14.300  1.000
 

08003790 8    Tomato, juice                      0.600000   1.500  1.000
 

09020210 9B   Balsam pear                        0.700000   1.000  1.000
 

09010750 9A   Cantaloupe                         0.700000   1.000  1.000
 

09010800 9A   Casaba                             0.700000   1.000  1.000
 

09020880 9B   Chayote, fruit                     0.700000   1.000  1.000
 

09021020 9B   Chinese waxgourd                   0.700000   1.000  1.000
 

09021350 9B   Cucumber                           0.700000   1.000  1.000
 

09011870 9A   Honeydew melon                     0.700000   1.000  1.000
 

09023080 9B   Pumpkin                            0.700000   1.000  1.000
 

09023090 9B   Pumpkin, seed                      0.700000   1.000  1.000
 

09023560 9B   Squash, summer                     0.700000   1.000  1.000
 

09023561 9B   Squash, summer-babyfood            0.700000   1.000  1.000
 

09023570 9B   Squash, winter                     0.700000   1.000  1.000
 

09023571 9B   Squash, winter-babyfood            0.700000   1.000  1.000
 

09013990 9A   Watermelon                         0.700000   1.000  1.000
 

09014000 9A   Watermelon, juice                  0.700000   1.000  1.000
 

10001060 10   Citrus citron                      0.600000   1.000  1.000
 

10001070 10   Citrus hybrids                     0.600000   1.000  1.000
 

10001080 10   Citrus, oil                       25.000000   1.000  1.000
 

10001800 10   Grapefruit                         0.600000   1.000  1.000
 

10001810 10   Grapefruit, juice                  0.600000   0.100  1.000
 

10001970 10   Kumquat                            0.600000   1.000  1.000
 

10001990 10   Lemon                              0.600000   1.000  1.000
 

10002000 10   Lemon, juice                       0.600000   0.100  1.000
 

10002001 10   Lemon, juice-babyfood              0.600000   0.100  1.000
 

10002010 10   Lemon, peel                        0.600000   1.000  1.000
 

10002060 10   Lime                               0.600000   1.000  1.000
 

10002070 10   Lime, juice                        0.600000   0.100  1.000
 

10002071 10   Lime, juice-babyfood               0.600000   0.100  1.000
 

10002400 10   Orange                             0.600000   1.000  1.000
 

10002410 10   Orange, juice                      0.600000   0.100  1.000
 

10002411 10   Orange, juice-babyfood             0.600000   0.100  1.000
 

10002420 10   Orange, peel                       0.600000   1.000  1.000
 

10003070 10   Pummelo                            0.600000   1.000  1.000
 

10003690 10   Tangerine                          0.600000   1.000  1.000
 

10003700 10   Tangerine, juice                   0.600000   0.100  1.000
 

11000070 11   Apple, fruit with peel             1.000000   1.000  1.000
 

11000080 11   Apple, peeled fruit                1.000000   1.000  1.000
 

11000081 11   Apple, peeled fruit-babyfood       1.000000   1.000  1.000
 

11000090 11   Apple, dried                       1.000000   8.000  1.000
 

11000091 11   Apple, dried-babyfood              1.000000   8.000  1.000
 

11000100 11   Apple, juice                       1.000000   0.040  1.000
 

11000101 11   Apple, juice-babyfood              1.000000   0.040  1.000
 

11000110 11   Apple, sauce                       1.000000   1.000  1.000
 

11000111 11   Apple, sauce-babyfood              1.000000   1.000  1.000
 

11001290 11   Crabapple                          1.000000   1.000  1.000
 

11002100 11   Loquat                             1.000000   1.000  1.000
 

11002660 11   Pear                               1.000000   1.000  1.000
 

11002661 11   Pear-babyfood                      1.000000   1.000  1.000
 

11002670 11   Pear, dried                        1.000000   6.250  1.000
 

11002680 11   Pear, juice                        1.000000   1.000  1.000
 

11002681 11   Pear, juice-babyfood               1.000000   1.000  1.000
 

11003100 11   Quince                             1.000000   1.000  1.000
 

14000030 14   Almond                             0.030000   1.000  1.000
 

14000031 14   Almond-babyfood                    0.030000   1.000  1.000
 

14000040 14   Almond, oil                        0.030000   1.000  1.000
 

14000041 14   Almond, oil-babyfood               0.030000   1.000  1.000
 

14000590 14   Brazil nut                         0.030000   1.000  1.000
 

14000680 14   Butternut                          0.030000   1.000  1.000
 

14000810 14   Cashew                             0.030000   1.000  1.000
 

14000920 14   Chestnut                           0.030000   1.000  1.000
 

14001550 14   Filbert                            0.030000   1.000  1.000
 

14001560 14   Filbert, oil                       0.030000   1.000  1.000
 

14001850 14   Hickory nut                        0.030000   1.000  1.000
 

14002130 14   Macadamia nut                      0.030000   1.000  1.000
 

14002690 14   Pecan                              0.030000   1.000  1.000
 

14002820 14   Pistachio                          0.030000   1.000  1.000
 

14003910 14   Walnut                             0.030000   1.000  1.000
 

15000250 15   Barley, pearled barley             0.100000   1.000  1.000
 

15000251 15   Barley, pearled barley-babyfood    0.100000   1.000  1.000
 

15000260 15   Barley, flour                      0.100000   1.000  1.000
 

15000261 15   Barley, flour-babyfood             0.100000   1.000  1.000
 

15000270 15   Barley, bran                       0.100000   1.000  1.000
 

15001270 15   Corn, sweet                        0.010000   1.000  1.000
 

15001271 15   Corn, sweet-babyfood               0.010000   1.000  1.000
 

15003280 15   Rye, grain                         0.100000   1.000  1.000
 

15003290 15   Rye, flour                         0.100000   1.000  1.000
 

15004010 15   Wheat, grain                       0.100000   1.000  1.000
 

15004011 15   Wheat, grain-babyfood              0.100000   1.000  1.000
 

15004020 15   Wheat, flour                       0.100000   1.000  1.000
 

15004021 15   Wheat, flour-babyfood              0.100000   1.000  1.000
 

15004030 15   Wheat, germ                        0.100000   1.000  1.000
 

15004040 15   Wheat, bran                        0.100000   1.000  1.000
 



Attachment 2:  DEEM-FCID( Acute Exposure Estimates

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for DIFENOCONAZOLE                     
(1994-98 data)

Residue file: difenoconazole_acute-01-10.R98          Adjustment factor
#2 used.

Analysis Date: 01-12-2010/14:29:03    Residue file dated:
01-12-2010/14:23:34/8

Daily totals for food and foodform consumption used.

Run Comment: ""

========================================================================
=======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
--------

U.S. Population:

                    0.017747     7.10    0.051415    20.57    0.142474  
 56.99 

All infants:

                    0.025139    10.06    0.040570    16.23    0.118410  
 47.36 

Children 1-2 yrs:

                    0.039565    15.83    0.087361    34.94    0.251716  
100.69 

Children 3-5 yrs:

                    0.031818    12.73    0.070329    28.13    0.373423  
149.37 

Children 6-12 yrs:

                    0.017949     7.18    0.038892    15.56    0.148702  
 59.48 

Youth 13-19 yrs:

                    0.008828     3.53    0.039549    15.82    0.137882  
 55.15 

Adults 20-49 yrs:

                    0.013083     5.23    0.041933    16.77    0.109522  
 43.81 

Adults 50+ yrs:

                    0.017255     6.90    0.062629    25.05    0.138639  
 55.46 

Females 13-49 yrs:

                    0.013281     5.31    0.042028    16.81    0.116292  
 46.52 

Attachment 3:  DEEM-FCID( Chronic Residue File

  Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM
Files\128847 DifenocozoleNew Uses of Wax Apple and
Mango\difenoconazole_chronic-01-10AverageFT.R98

Chemical: Difenoconazole

RfD(Chronic): .01 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .25 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 01-12-2010/10:31:20/8          Program ver.
2.03

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

95000230 O    Banana                             0.200000   1.000  1.000
 

95000231 O    Banana-babyfood                    0.200000   1.000  1.000
 

95000240 O    Banana, dried                      0.200000   3.900  1.000
 

95000241 O    Banana, dried-babyfood             0.200000   3.900  1.000
 

95001280 O    Cottonseed, oil                    0.050000   1.000  1.000
 

95001281 O    Cottonseed, oil-babyfood           0.050000   1.000  1.000
 

95001750 O    Grape                              0.613000   1.000  1.000
 

95001760 O    Grape, juice                       0.613000   0.200  1.000
 

95001761 O    Grape, juice-babyfood              0.613000   0.200  1.000
 

95001770 O    Grape, leaves                      0.613000   1.000  1.000
 

95001780 O    Grape, raisin                      0.613000   3.500  1.000
 

95001790 O    Grape, wine and sherry             0.613000   1.000  1.000
 

95002150 O    Mango                              0.070000   1.000  1.000
 

95002151 O    Mango-babyfood                     0.070000   1.000  1.000
 

95002160 O    Mango, dried                       0.070000   1.000  1.000
 

95002170 O    Mango, juice                       0.070000   1.000  1.000
 

95002171 O    Mango, juice-babyfood              0.070000   1.000  1.000
 

95002450 O    Papaya                             0.300000   1.000  1.000
 

95002451 O    Papaya-babyfood                    0.300000   1.000  1.000
 

95002460 O    Papaya, dried                      0.300000   1.800  1.000
 

95002470 O    Papaya, juice                      0.300000   1.500  1.000
 

95002830 O    Plantain                           0.200000   1.000  1.000
 

95002840 O    Plantain, dried                    0.200000   3.900  1.000
 

86010000 O    Water, direct, all sources         0.010400   1.000  1.000
 

86020000 O    Water, indirect, all sources       0.010400   1.000  1.000
 

21000440 M    Beef, meat                         0.050000   1.000  1.000
 

21000441 M    Beef, meat-babyfood                0.050000   1.000  1.000
 

21000450 M    Beef, meat, dried                  0.050000   1.920  1.000
 

21000460 M    Beef, meat byproducts              0.100000   1.000  1.000
 

21000461 M    Beef, meat byproducts-babyfood     0.100000   1.000  1.000
 

21000470 M    Beef, fat                          0.100000   1.000  1.000
 

21000471 M    Beef,fat-babyfood                  0.100000   1.000  1.000
 

21000480 M    Beef, kidney                       0.100000   1.000  1.000
 

21000490 M    Beef, liver                        0.200000   1.000  1.000
 

21000491 M    Beef, liver-babyfood               0.200000   1.000  1.000
 

23001690 M    Goat, meat                         0.050000   1.000  1.000
 

23001700 M    Goat, meat byproducts              0.100000   1.000  1.000
 

23001710 M    Goat, fat                          0.100000   1.000  1.000
 

23001720 M    Goat, kidney                       0.100000   1.000  1.000
 

23001730 M    Goat, liver                        0.200000   1.000  1.000
 

24001890 M    Horse, meat                        0.050000   1.000  1.000
 

25002900 M    Pork, meat                         0.050000   1.000  1.000
 

25002901 M    Pork, meat-babyfood                0.050000   1.000  1.000
 

25002910 M    Pork, skin                         0.100000   1.000  1.000
 

25002920 M    Pork, meat byproducts              0.100000   1.000  1.000
 

25002921 M    Pork, meat byproducts-babyfood     0.100000   1.000  1.000
 

25002930 M    Pork, fat                          0.100000   1.000  1.000
 

25002931 M    Pork, fat-babyfood                 0.100000   1.000  1.000
 

25002940 M    Pork, kidney                       0.100000   1.000  1.000
 

25002950 M    Pork, liver                        0.200000   1.000  1.000
 

26003390 M    Sheep, meat                        0.050000   1.000  1.000
 

26003391 M    Sheep, meat-babyfood               0.050000   1.000  1.000
 

26003400 M    Sheep, meat byproducts             0.100000   1.000  1.000
 

26003410 M    Sheep, fat                         0.100000   1.000  1.000
 

26003411 M    Sheep, fat-babyfood                0.100000   1.000  1.000
 

26003420 M    Sheep, kidney                      0.100000   1.000  1.000
 

26003430 M    Sheep, liver                       0.200000   1.000  1.000
 

70001450 P    Egg, whole                         0.100000   1.000  1.000
 

70001451 P    Egg, whole-babyfood                0.100000   1.000  1.000
 

70001460 P    Egg, white                         0.100000   1.000  1.000
 

70001461 P    Egg, white (solids)-babyfood       0.100000   1.000  1.000
 

70001470 P    Egg, yolk                          0.100000   1.000  1.000
 

70001471 P    Egg, yolk-babyfood                 0.100000   1.000  1.000
 

27002220 D    Milk, fat                          0.010000   1.000  1.000
 

27002221 D    Milk, fat - baby food/infant for   0.010000   1.000  1.000
 

27012230 D    Milk, nonfat solids                0.010000   1.000  1.000
 

27012231 D    Milk, nonfat solids-baby food/in   0.010000   1.000  1.000
 

27022240 D    Milk, water                        0.010000   1.000  1.000
 

27022241 D    Milk, water-babyfood/infant form   0.010000   1.000  1.000
 

27032251 D    Milk, sugar (lactose)-baby food/   0.010000   1.000  1.000
 

01010520 1A   Beet, sugar                        0.300000   1.000  1.000
 

01010521 1A   Beet, sugar-babyfood               0.300000   1.000  1.000
 

01010530 1A   Beet, sugar, molasses              0.300000   0.600  1.000
 

01010531 1A   Beet, sugar, molasses-babyfood     0.300000   0.600  1.000
 

01032960 1C   Potato, chips                      0.005000   0.500  1.000
 

01032970 1C   Potato, dry (granules/ flakes)     0.005000   0.500  1.000
 

01032971 1C   Potato, dry (granules/ flakes)-b   0.005000   0.500  1.000
 

01032980 1C   Potato, flour                      0.005000   0.500  1.000
 

01032981 1C   Potato, flour-babyfood             0.005000   0.500  1.000
 

01032990 1C   Potato, tuber, w/peel              0.005000   1.000  1.000
 

01032991 1C   Potato, tuber, w/peel-babyfood     0.005000   1.000  1.000
 

01033000 1C   Potato, tuber, w/o peel            0.005000   1.000  1.000
 

01033001 1C   Potato, tuber, w/o peel-babyfood   0.005000   1.000  1.000
 

03001640 3    Garlic                             0.200000   1.000  1.000
 

03001650 3    Garlic, dried                      0.200000   1.000  1.000
 

03001651 3    Garlic, dried-babyfood             0.200000   1.000  1.000
 

03001980 3    Leek                               6.000000   1.000  1.000
 

03002370 3    Onion, dry bulb                    0.200000   1.000  1.000
 

03002371 3    Onion, dry bulb-babyfood           0.200000   1.000  1.000
 

03002380 3    Onion, dry bulb, dried             0.200000   9.000  1.000
 

03002381 3    Onion, dry bulb, dried-babyfood    0.200000   9.000  1.000
 

03002390 3    Onion, green                       6.000000   1.000  1.000
 

03003380 3    Shallot                            0.200000   1.000  1.000
 

05010610 5A   Broccoli                           0.221000   1.000  1.000
 

05010611 5A   Broccoli-babyfood                  0.221000   1.000  1.000
 

05010620 5A   Broccoli, Chinese                  0.221000   1.000  1.000
 

05020630 5B   Broccoli raab                      5.100000   1.000  1.000
 

05010640 5A   Brussels sprouts                  29.000000   1.000  1.000
 

05010690 5A   Cabbage                            0.029000   1.000  1.000
 

05020700 5B   Cabbage, Chinese, bok choy         5.100000   1.000  1.000
 

05010710 5A   Cabbage, Chinese, napa             0.029000   1.000  1.000
 

05010720 5A   Cabbage, Chinese, mustard          0.221000   1.000  1.000
 

05010830 5A   Cauliflower                        0.221000   1.000  1.000
 

05021170 5B   Collards                           5.100000   1.000  1.000
 

05021940 5B   Kale                               5.100000   1.000  1.000
 

05011960 5A   Kohlrabi                           0.029000   1.000  1.000
 

05022290 5B   Mustard greens                     5.100000   1.000  1.000
 

05023180 5B   Rape greens                        5.100000   1.000  1.000
 

05023890 5B   Turnip, greens                     5.100000   1.000  1.000
 

08001480 8    Eggplant                           0.133000   1.000  1.000
 

08002340 8    Okra                               0.600000   1.000  1.000
 

08002700 8    Pepper, bell                       0.133000   1.000  1.000
 

08002701 8    Pepper, bell-babyfood              0.133000   1.000  1.000
 

08002710 8    Pepper, bell, dried                0.133000   1.000  1.000
 

08002711 8    Pepper, bell, dried-babyfood       0.133000   1.000  1.000
 

08002720 8    Pepper, nonbell                    0.133000   1.000  1.000
 

08002721 8    Pepper, nonbell-babyfood           0.133000   1.000  1.000
 

08002730 8    Pepper, nonbell, dried             0.133000   1.000  1.000
 

08003740 8    Tomatillo                          0.165000   1.000  1.000
 

08003750 8    Tomato                             0.165000   1.000  1.000
 

08003751 8    Tomato-babyfood                    0.165000   1.000  1.000
 

08003760 8    Tomato, paste                      0.165000   1.600  1.000
 

08003761 8    Tomato, paste-babyfood             0.165000   1.600  1.000
 

08003770 8    Tomato, puree                      0.165000   0.500  1.000
 

08003771 8    Tomato, puree-babyfood             0.165000   0.500  1.000
 

08003780 8    Tomato, dried                      0.165000  14.300  1.000
 

08003781 8    Tomato, dried-babyfood             0.165000  14.300  1.000
 

08003790 8    Tomato, juice                      0.165000   1.500  1.000
 

09020210 9B   Balsam pear                        0.055000   1.000  1.000
 

09010750 9A   Cantaloupe                         0.137000   1.000  1.000
 

09010800 9A   Casaba                             0.137000   1.000  1.000
 

09020880 9B   Chayote, fruit                     0.310000   1.000  1.000
 

09021020 9B   Chinese waxgourd                   0.055000   1.000  1.000
 

09021350 9B   Cucumber                           0.055000   1.000  1.000
 

09011870 9A   Honeydew melon                     0.137000   1.000  1.000
 

09023080 9B   Pumpkin                            0.031000   1.000  1.000
 

09023090 9B   Pumpkin, seed                      0.031000   1.000  1.000
 

09023560 9B   Squash, summer                     0.031000   1.000  1.000
 

09023561 9B   Squash, summer-babyfood            0.031000   1.000  1.000
 

09023570 9B   Squash, winter                     0.031000   1.000  1.000
 

09023571 9B   Squash, winter-babyfood            0.031000   1.000  1.000
 

09013990 9A   Watermelon                         0.137000   1.000  1.000
 

09014000 9A   Watermelon, juice                  0.137000   1.000  1.000
 

10001060 10   Citrus citron                      0.208000   1.000  1.000
 

10001070 10   Citrus hybrids                     0.208000   1.000  1.000
 

10001080 10   Citrus, oil                       25.000000   1.000  1.000
 

10001800 10   Grapefruit                         0.120000   1.000  1.000
 

10001810 10   Grapefruit, juice                  0.120000   0.100  1.000
 

10001970 10   Kumquat                            0.208000   1.000  1.000
 

10001990 10   Lemon                              0.176000   1.000  1.000
 

10002000 10   Lemon, juice                       0.176000   0.100  1.000
 

10002001 10   Lemon, juice-babyfood              0.176000   0.100  1.000
 

10002010 10   Lemon, peel                        0.176000   1.000  1.000
 

10002060 10   Lime                               0.176000   1.000  1.000
 

10002070 10   Lime, juice                        0.176000   0.100  1.000
 

10002071 10   Lime, juice-babyfood               0.176000   0.100  1.000
 

10002400 10   Orange                             0.208000   1.000  1.000
 

10002410 10   Orange, juice                      0.208000   0.100  1.000
 

10002411 10   Orange, juice-babyfood             0.208000   0.100  1.000
 

10002420 10   Orange, peel                       0.208000   1.000  1.000
 

10003070 10   Pummelo                            0.120000   1.000  1.000
 

10003690 10   Tangerine                          0.208000   1.000  1.000
 

10003700 10   Tangerine, juice                   0.208000   0.100  1.000
 

11000070 11   Apple, fruit with peel             0.203000   1.000  1.000
 

11000080 11   Apple, peeled fruit                0.203000   1.000  1.000
 

11000081 11   Apple, peeled fruit-babyfood       0.203000   1.000  1.000
 

11000090 11   Apple, dried                       0.203000   8.000  1.000
 

11000091 11   Apple, dried-babyfood              0.203000   8.000  1.000
 

11000100 11   Apple, juice                       0.203000   0.040  1.000
 

11000101 11   Apple, juice-babyfood              0.203000   0.040  1.000
 

11000110 11   Apple, sauce                       0.203000   1.000  1.000
 

11000111 11   Apple, sauce-babyfood              0.203000   1.000  1.000
 

11001290 11   Crabapple                          0.203000   1.000  1.000
 

11002100 11   Loquat                             0.123000   1.000  1.000
 

11002660 11   Pear                               0.123000   1.000  1.000
 

11002661 11   Pear-babyfood                      0.123000   1.000  1.000
 

11002670 11   Pear, dried                        0.123000   6.250  1.000
 

11002680 11   Pear, juice                        0.123000   1.000  1.000
 

11002681 11   Pear, juice-babyfood               0.123000   1.000  1.000
 

11003100 11   Quince                             0.123000   1.000  1.000
 

14000030 14   Almond                             0.005000   1.000  1.000
 

14000031 14   Almond-babyfood                    0.005000   1.000  1.000
 

14000040 14   Almond, oil                        0.005000   1.000  1.000
 

14000041 14   Almond, oil-babyfood               0.005000   1.000  1.000
 

14000590 14   Brazil nut                         0.007000   1.000  1.000
 

14000680 14   Butternut                          0.007000   1.000  1.000
 

14000810 14   Cashew                             0.007000   1.000  1.000
 

14000920 14   Chestnut                           0.005000   1.000  1.000
 

14001550 14   Filbert                            0.007000   1.000  1.000
 

14001560 14   Filbert, oil                       0.007000   1.000  1.000
 

14001850 14   Hickory nut                        0.007000   1.000  1.000
 

14002130 14   Macadamia nut                      0.007000   1.000  1.000
 

14002690 14   Pecan                              0.007000   1.000  1.000
 

14002820 14   Pistachio                          0.005000   1.000  1.000
 

14003910 14   Walnut                             0.007000   1.000  1.000
 

15000250 15   Barley, pearled barley             0.100000   1.000  1.000
 

15000251 15   Barley, pearled barley-babyfood    0.100000   1.000  1.000
 

15000260 15   Barley, flour                      0.100000   1.000  1.000
 

15000261 15   Barley, flour-babyfood             0.100000   1.000  1.000
 

15000270 15   Barley, bran                       0.100000   1.000  1.000
 

15001270 15   Corn, sweet                        0.010000   1.000  1.000
 

15001271 15   Corn, sweet-babyfood               0.010000   1.000  1.000
 

15003280 15   Rye, grain                         0.100000   1.000  1.000
 

15003290 15   Rye, flour                         0.100000   1.000  1.000
 

15004010 15   Wheat, grain                       0.100000   1.000  1.000
 

15004011 15   Wheat, grain-babyfood              0.100000   1.000  1.000
 

15004020 15   Wheat, flour                       0.100000   1.000  1.000
 

15004021 15   Wheat, flour-babyfood              0.100000   1.000  1.000
 

15004030 15   Wheat, germ                        0.100000   1.000  1.000
 

15004040 15   Wheat, bran                        0.100000   1.000  1.000
 

Attachment 4:  DEEM-FCID( Chronic Exposure Estimates

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for DIFENOCONAZOLE                   (1994-98
data)

Residue file name: C:\Documents and Settings\tmorton\My
Documents\MyFiles\DEEM Files\128847 DifenocozoleNew Uses of Wax Apple
and Mango\difenoconazole_chronic-01-10AverageFT.R98

                                                     Adjustment factor
#2 used.

Analysis Date 01-12-2010/14:26:21     Residue file dated:
01-12-2010/14:24:16/8

Reference dose (RfD, Chronic) = .01 mg/kg bw/day

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.001709               
17.1%

U.S. Population (spring season)             0.001689               
16.9%

U.S. Population (summer season)             0.001761               
17.6%

U.S. Population (autumn season)             0.001678               
16.8%

U.S. Population (winter season)             0.001710               
17.1%

Northeast region                            0.001653               
16.5%

Midwest region                              0.001671               
16.7%

Southern region                             0.001610               
16.1%

Western region                              0.001958               
19.6%

Hispanics                                   0.001635               
16.3%

Non-hispanic whites                         0.001626               
16.3%

Non-hispanic blacks                         0.002000               
20.0%

Non-hisp/non-white/non-black                0.002426               
24.3%

All infants (< 1 year)                      0.002445               
24.5%

Nursing infants                             0.001287               
12.9%

Non-nursing infants                         0.002885               
28.9%

Children 1-6  yrs                           0.003762               
37.6%

Children 7-12 yrs                           0.001941               
19.4%

Females 13-19 (not preg or nursing)         0.001233               
12.3%

Females 20+ (not preg or nursing)           0.001490               
14.9%

Females 13-50 yrs                           0.001475               
14.7%

Females 13+ (preg/not nursing)              0.001295               
13.0%

Females 13+ (nursing)                       0.001522               
15.2%

Males 13-19 yrs                             0.001506               
15.1%

Males 20+ yrs                               0.001385               
13.9%

Seniors 55+                                 0.001574               
15.7%

Children 1-2 yrs                            0.004484               
44.8%

Children 3-5 yrs                            0.003624               
36.2%

Children 6-12 yrs                           0.002061               
20.6%

Youth 13-19 yrs                             0.001372               
13.7%

hfr

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Adults 20-49 yrs                            0.001376               
13.8%

Adults 50+ yrs                              0.001548               
15.5%

Females 13-49 yrs                           0.001402               
14.0%

------------------------------------------------------------------------
-------

Difenoconazole	Dietary Exposure Assessment	DP#: 371613

PC Code: 128847

  PAGE  1  of   NUMPAGES  19