Document ID: EPA-HQ-OPP-2003-0100-0004
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2003-05-28T04:00Z

Syngenta
Seeds
P.
O.
Box
12257
3054
Cornwallis
Road
Research
Triangle
Park,
North
Carolina
27709­
2257
Telephone
919­
597­
3068
Telefax
919­
541­
8535
Lori
Artim
Regulatory
Affairs
 
NAFTA
December
23,
2002
Submitter:
Syngenta
Seeds,
Inc.
Attention:
Lori
Artim
P.
O.
Box
12257
3054
Cornwallis
Road
Research
Triangle
Park,
NC
27709­
2257
EPA
Company
Number:
67979
Subject:
Registration
Application
for
the
Plant
Incorporated
Protectant
Bacillus
thuringiensis
VIP3A
Insect
Control
Protein
as
Expressed
in
Event
COT102
Derived
Cotton
Plants
Volum
e
Study
Title
MRID
1
Registration
Application
Administrative
Materials
N/
A
2
Quantification
of
VIP3A
and
APH4
Protein
in
Cotton
Tissues
and
Whole
Plants
Derived
from
Transformation
Event
"
COT102"
3
Molecular
Characterization
and
Genetic
Stability
of
Event
COT102
4
Analysis
of
Processed
COT102
Cottonseed
Products
For
Yield
and
Presence
of
Gossypol
and
VIP3A
Protein
5
Summary
of
Mammalian
Safety
Data
for
the
VIP3A
and
APH4
Proteins
Produced
by
Transgenic
VIP3A
Cotton
Event
COT102;
Supplement
to
MRID
No.
45766502
6
In
Vitro
Digestibility
of
VIP3A
Protein
Under
Simulated
Mammalian
Gastric
Conditions
7
In
Vitro
Digestibility
of
APH4
Protein
Under
Simulated
Mammalian
Gastric
Conditions
8
APH4­
0102:
Acute
Oral
Toxicity
of
APH4
Protein
in
the
Mouse
9
Environmental
Safety
Assessment
of
Bacillus
thuringiensis
VIP3A
Protein
and
VIP3A
Cotton
Event
COT102
to
Non­
Target
Organisms
10
VIP3A
Inbred
Maize
(
Corn)
Pollen:
Toxicity
to
Green
Lacewing
(
Chrysoperla
carnea)
11
Evaluation
of
the
Dietary
Effect(
s)
of
Transgenic
VIP3A
Maize
(
Corn)
Pollen
(
Sample
PHOPACHA­
0199)
on
Honeybee
Development
12
Impact
of
VIP3A
AND
CRY1Ab
Transgenic
Maize
(
Corn)
Leaf
Tissue
(
Samples
LLPACHA­
0100,
LLBt11­
0100,
AND
LLPACHABt11­
0100)
on
28­
Day
Survival
and
Reproduction
of
Collembola
(
Folsomia
candida)
13
Biological
Activity
of
VIP3A
Maize
(
Corn)
Leaf
Protein
(
Sample
LPPACHA­
0199)
in
Various
Soils
14
Characterization
of
VIP3A
Protein
Produced
in
COT102­
Derived
Cotton
and
Comparison
with
VIP3A
Protein
Expressed
in
Both
Maize
(
Corn)
Derived
From
Event
PACHA
and
Recombinant
Escherichia
coli
15
Impact
of
Transgenic
Lepidopteran­
Resistant
VIP3A
Field
Corn
(
Maize)
on
Honey
Bee
Colonies
in
a
Semi­
field
Setting
16
Insect
Resistance
Management
Considerations
for
Event
COT102
Cotton
17
Summary
of
Data
on
VIP3A
and
APH4
Protein
Levels
in
Event
COT102
Cotton
Plants
and
the
Environmental
Fate
of
VIP3A
Protein