Document ID: EPA-HQ-OPP-2006-0201-0158
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2006-10-04T04:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

					WASHINGTON, D.C.  20460

OFFICE OF              

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES 

01/31/2006

MEMORANDUM

SUBJECT:		METHANEARSONIC ACID (MAA) AND SALTS [MSMA/DSMA] Product
Chemistry Chapter for the Reregistration Eligibility Decision [RED] 

		DP Barcode:	D325973

		PC Code(s):    	013802 and 013803

		Chemical Class: Organo Arsenical

FROM:	P. Yvonne Barnes, Chemist

Reregistration Branch 2

Health Effects Division [7509C]

THRU:	Alan Nielsen, Branch Senior Scientist

Reregistration Branch 2

Health Effects Division [7509C]

TO:		Diana Locke, Ph.D., Risk Assessor

Reregistration Branch 2

Health Effects Division [7509C]

  SEQ CHAPTER \h \r 1 The summary analytical chemistry and residue data
document was originally prepared under contract by Dynamac Corporation,
The Dynamac Building 2275 Research Boulevard Rockville, MD 20850-3268.

	

	METHANEARSONIC ACID (MAA) AND SALTS

	REREGISTRATION ELIGIBILITY DECISION:

	PRODUCT CHEMISTRY CONSIDERATIONS

	Case No. 2395 for PC Codes 013802 and 013806

DESCRIPTION OF CHEMICAL

Methanearsonic acid and its salts are selective post-emergence organic
arsenical herbicides registered for use on cotton, nonbearing fruits
(including almond, apple, cherry, grapefruit, lemon, lime, orange,
peach, pear, pecan, plum/prune, tangerine, walnut), bearing citrus, and
non-crop areas (including lawns and ornamental turf).  Of the five
methanearsonic salts, only the disodium salt (DSMA, PC Code 013802) and
the monosodium salt (MSMA, PC Code 013803) are registered for food/feed
uses and are being supported for reregistration.  There are no active
products registered for the MAA octylammonium and dodecylammonium salts
(PC Codes 013804 and 013805), and there are no registered food/feed uses
for the MAA calcium salt (CAMA, PC Code 013806).  Reregistration of DSMA
and MSMA is being supported by the MAA Research Task Force, which
consists of APC Holding Company, KMG - Bernuth, Inc., and
Luxembourg-Pamol, Inc.

 

	

                   

 

       DSMA

Empirical Formula:	CH3AsNa2O3

Molecular Weight:	183.92

CAS Registry No.:	144-21-8

PC Code:			013802	

        MSMA

Empirical Formula:	CH4AsNaO3

Molecular Weight:	161.94

CAS Registry No.:	2163-80-6

PC Code:			013803

	

IDENTIFICATION OF ACTIVE INGREDIENT

DSMA is a white crystalline solid with a melting point >300 ºC, density
of 1.04 g/mL, vapor pressure of 1 x 10-7 mm Hg, and octanol/water
partition coefficient (log Pow) of <1 at 25 ºC.  DSMA is soluble in
water at 34.1 g/100 mL, and is soluble in methanol (26 g/100 mL) and
hexane (0.0025 g/100 mL). 

MSMA is a white crystalline solid with a melting point of 116-121 ºC,
density of 1.65 g/mL, vapor pressure of 1 x 10-5 Pa, and octanol/water
partition coefficient (log Pow) of <1 at 25 ºC.  MSMA is soluble in
water at 104 g/100 mL, is soluble in methanol (16 g/100 mL), and has
limited solubility in hexane (0.005 g/100 mL) at 25 ºC.



MANUFACTURING-USE PRODUCTS

The MAA Research Task Force (MAATF) supports the reregistration of DSMA
and MSMA, which consists of the following conglomerate: APC Holding
Company, Luxembourg-Pamol, Inc., and KMG-Bernuth, Inc.  According to the
MAATF, the registered DSMA and MSMA products  marketed as
manufacturing-use and/or end-use products will become consistent with
the Master Labels issued by the MAA Task Force. Note: The 81% DSMA FI is
repackaged from an EPA-registered product.  Because the methanearsonic
acid salts are List B chemicals, only the technical/technical grade
active ingredients [T/TGAIs] are subject to a reregistration eligibility
decision. 

REGULATORY BACKGROUND

DSMA and MSMA was the subject of the Methanearsonic Acid and Salts Phase
4 Reviews dated 03/28/1991 by C. Olinger.  Additional product chemistry
data were required for DSMA and MSMA products.  The status of the
product-chemistry data requirements for the DSMA and MSMA TGAIs and MPs
is presented in the attached data summary Tables 1 through 6.  Refer to
these tables for a listing of the outstanding product-chemistry data
requirements. 

CONCLUSIONS

Pertinent product chemistry data requirements that remain unfulfilled
for the DSMA and MSMA T/TGAIs are listed in the tables as well as the
81% DSMA FI.  The 81% DSMA FI is repackaged from an EPA-registered
product, all product chemistry data requirements may be satisfied by
data for the source product.  

Provided that the registrants submit the data required in the attached
data summary tables for the DSMA and MSMA TGAIs, and either certify that
the suppliers of beginning materials and the manufacturing processes
have not changed since the last comprehensive product chemistry reviews
or submit complete updated product chemistry data packages, HED has no
objections to the reregistration of DSMA and MSMA with respect to
product chemistry data requirements.

Case No. 2395

Case Name:  Methanearsonic acid salts

Registrant:  Luxembourg-Pamol, Inc.

Product(s):  DSMA TGAI

	PRODUCT CHEMISTRY DATA SUMMARY

Table 1.    Product Chemistry Data Summary for Disodium Methanearsonic
salt  SEQ CHAPTER \h \r 1 

OPPTS Guideline Numbers	Luxembourg-Pamol, Inc.

Data Requirements: DSMA [TGAI]

PC Code: 013802

CAS No.: 144-21-8	Master Record Identification [MRID] 	

Data Requirements Fulfilled	

Results

 Or

 *Data Gap

830.1550	Product Identity and Composition  

No	* Data Gap

830.1600

	Description of Materials Used to Produce the Product	42388301,

44150401	Yes

	830.1620	Description of Production Process	42388301,

44150401	Yes

	830.1650	Description of Formulation Process

No	* Data Gap

830.1670	Discussion of Formation of Impurities

No	* Data Gap

830.1700	Preliminary Analysis	42053701, 45053702 	YES

	830.1750	Certified Limits

No	* Data Gap

830.1800	Enforcement Analytical Method

No	* Data Gap

830.1900	Submittal of Samples

No	* Data Gap

830.6302	Color	42451102	YES	WHITE

830.6303	Physical State	42451102	YES	CRYSTALINE SOLID

830.6304	Odor	42451102	YES	No Odor

830.6313	Stability to normal and elevated temperatures, metals and metal
ions

No	* Data Gap

830.7000	pH	41982002	Yes

	830.7050	UV/VIS absorption

No	* Data Gap

830.7200	Melting Point/Melting Range	41982001	YES	>300 ºC

830.7220	Boiling Point/Boiling Point Range	Not Applicable

830.7300	Density/Relative Density/Bulk Density	42451102	Yes

	830.7370	Dissociation  Constant	41976201	Yes

	830.7550	Partition coefficient (n-octanol /water) shake flask method
41976202	Yes	Log P O/W  <1.0

830.7560	Partition coefficient (n-octanol /water) generator column
method	

See guideline 830.7550

830.7570	Partition coefficient (n-octanol /water) estimation by liquid
chromatography

	830.7840	Water Solubility: Column Elution Method; Shake Flask Method
41602502	Yes

	830.7860	Water solubility, generator column method	See guideline
830.7840

830.7950	Vapor pressure	42120701	Yes	0.0000001 mm Hg at 25 °C 



Case No. 2395

Case Name:  Methanearsonic acid salts

Registrant:  APC Holdings, Inc.

Product(s):  DSMA TGAI

	PRODUCT CHEMISTRY DATA SUMMARY

Table 2.   Product Chemistry Data Summary for Disodium Methanearsonic
salt   SEQ CHAPTER \h \r 1 

OPPTS Guideline Numbers	APC Holdings

Data Requirements: DSMA [TGAI]

PC Code: 013802

CAS No.: 144-21-8	Master Record Identification [MRID] 	

Data Requirements Fulfilled	

Results

 or 

*Data Gap

830.1550	Product Identity and Composition  

No	* Data Gap

830.1600

	Description of Materials Used to Produce the Product	42361001	Yes

	830.1620	Description of Production Process	42361001	Yes

	830.1650	Description of Formulation Process

No	* Data Gap

830.1670	Discussion of Formation of Impurities	42053701	Yes

	830.1700	Preliminary Analysis	42053702 	YES

	830.1750	Certified Limits

No	* Data Gap

830.1800	Enforcement Analytical Method

No	* Data Gap

830.1900	Submittal of Samples

No	* Data Gap

830.6302	Color	42451102	YES

	830.6303	Physical State	42451102	YES

	830.6304	Odor	42451102	YES	No Odor

830.6313	Stability to normal and elevated temperatures, metals and metal
ions

No	* Data Gap

830.7000	pH	41982002	Yes

	830.7050	UV/VIS absorption

No	* Data Gap

830.7200	Melting Point/Melting Range	41982001	YES

	830.7220	Boiling Point/Boiling Point Range	See guideline 830.7200

830.7300	Density/Relative Density/Bulk Density	42451102	Yes

	830.7370	Dissociation  Constant	41976201	Yes

	830.7550	Partition coefficient (n-octanol /water) shake flask method
41976202	Yes

	830.7560	Partition coefficient (n-octanol /water) generator column
method	See guideline 830.7550

830.7570	Partition coefficient (n-octanol /water) estimation by liquid
chromatography

	830.7840	Water Solubility: Column Elution Method; Shake Flask Method
41602502	Yes

	830.7860	Water solubility, generator column method	See guideline
830.7840

830.7950	Vapor pressure	42120701	Yes

	Case No. 2395

Case Name:  Methanearsonic acid salts

Registrant:  GB Biosciences Corporation

Product(s):  81% DSMA FI 

	PRODUCT CHEMISTRY DATA SUMMARY

Table 3.    Product Chemistry Data Summary for Disodium Methanearsonic
salt   SEQ CHAPTER \h \r 1 

OPPTS Guideline Numbers	GB Biosciences Corporation

Data Requirements: 81% DSMA  FI [Technical]

PC Code: 013802, CAS No.: 144-21-8	Master Record Identification [MRID] 	

Data Requirements Fulfilled	

Results 

or 

*Data Gap

830.1550	Product Identity and Composition  	42051902	Yes	CSF 09/23/1991

830.1600

	Description of Materials Used to Produce the Product

NO	* Data Gap

830.1620	Description of Production Process

NO	* Data Gap

830.1650	Description of Formulation Process

No	* Data Gap

830.1670	Discussion of Formation of Impurities

No	* Data Gap

830.1700	Preliminary Analysis

No	* Data Gap

830.1750	Certified Limits	42051902, CSF 09/23/1991	YES

	830.1800	Enforcement Analytical Method

No	* Data Gap

830.1900	Submittal of Samples

No	* Data Gap

830.6302	Color

No	* Data Gap

830.6303	Physical State

No	* Data Gap

830.6304	Odor

No	* Data Gap

830.6313	Stability to normal and elevated temperatures, metals and metal
ions

No	* Data Gap

830.7000	pH

No	* Data Gap

830.7050	UV/VIS absorption

No	* Data Gap

830.7200	Melting Point/Melting Range

No	* Data Gap

830.7220	Boiling Point/Boiling Point Range

No	* Data Gap

830.7300	Density/Relative Density/Bulk Density

No	* Data Gap

830.7370	Dissociation  Constant

No	* Data Gap

830.7550	Partition coefficient (n-octanol /water) shake flask method

No	* Data Gap

830.7560	Partition coefficient (n-octanol /water) generator column
method

	830.7570	Partition coefficient (n-octanol /water) estimation by liquid
chromatography

	830.7840	Water Solubility: Column Elution Method; Shake Flask Method

No  	* Data Gap

830.7860	Water solubility, generator column method

	830.7950	Vapor pressure

No	* Data Gap



Case No. 2395

Case Name:  Methanearsonic acid salts

Registrant:  Luxembourg-Pamol, Inc.

Product(s):  MSMA TGAI

	PRODUCT CHEMISTRY DATA SUMMARY

Table 4.    Product Chemistry Data Summary for Mono Sodium
Methanearsonic salt   SEQ CHAPTER \h \r 1 

OPPTS Guideline Numbers	Luxembourg-Pamol, Inc

Data Requirements: MSMA [TGAI]

PC Code: 013803

CAS No.: 2163-80-6	Master Record Identification [MRID] 	

Data Requirements Fulfilled	

Results

 or 

*Data Gap

830.1550	Product Identity and Composition  

No	* Data Gap

830.1600

	Description of Materials Used to Produce the Product

No	* Data Gap

830.1620	Description of Production Process	41602701, 42387801	Yes

	830.1650	Description of Formulation Process

No	* Data Gap

830.1670	Discussion of Formation of Impurities	41602701, 42387801	YES

	830.1700	Preliminary Analysis	42387802	YES

	830.1750	Certified Limits

NO	* Data Gap

830.1800	Enforcement Analytical Method

NO	* Data Gap

830.1900	Submittal of Samples

NO	* Data Gap

830.6302	Color	41610001,

42451101	YES	White

830.6303	Physical State	41610001,

42451101	YES	Crystalline 

830.6304	Odor	41610001,

42451101	YES	No Odor

830.6313	Stability to normal and elevated temperatures, metals and metal
ions	41610001,

42378601	YES

	830.7000	pH	41610001,

42378601	YES

	830.7050	UV/VIS absorption

No	* Data Gap

830.7200	Melting Point/Melting Range	41789501	YES

	830.7220	Boiling Point/Boiling Point Range	Not Applicable

830.7300	Density/Relative Density/Bulk Density	42451101	YES	1.65 g/ mL
at 25 ºC

830.7370	Dissociation  Constant	41610001	Yes

	830.7550	Partition coefficient (n-octanol /water) shake flask method	  
    	No	* Data Gap

830.7560	Partition coefficient (n-octanol /water) generator column
method

	830.7570	Partition coefficient (n-octanol /water) estimation by liquid
chromatography

	830.7840	Water Solubility: Column Elution Method; Shake Flask Method
41610001	Yes

	830.7860	Water solubility, generator column method	See guideline
830.7840

830.7950	Vapor pressure	41610001,

41651901	YES	0.00001 Pascal’s



Case No. 2395

Case Name:  Methanearsonic acid salts

Registrant:  APC Holdings, Inc.

Product(s):  MSMA TGAI

	PRODUCT CHEMISTRY DATA SUMMARY

Table 5.   Product Chemistry Data Summary for Mono Sodium Methanearsonic
salt   SEQ CHAPTER \h \r 1 

OPPTS Guideline Numbers	APC Holdings, Inc.

Data Requirements: MSMA [TGAI]

PC Code: 013803

CAS No.: 2163-80-6	Master Record Identification [MRID] 	

Data Requirements Fulfilled	

Results or *Data Gap

830.1550	Product Identity and Composition  

No	* Data Gap

830.1600

	Description of Materials Used to Produce the Product	41702001	Yes

	830.1620	Description of Production Process	41702001	Yes

	830.1650	Description of Formulation Process

No	* Data Gap

830.1670	Discussion of Formation of Impurities	42474101	YES

	830.1700	Preliminary Analysis	41702002, 42474101	YES

	830.1750	Certified Limits

NO	* Data Gap

830.1800	Enforcement Analytical Method

NO	* Data Gap

830.1900	Submittal of Samples

No	* Data Gap

830.6302	Color	41610001	YES

	830.6303	Physical State	41610001	YES

	830.6304	Odor	41610001	YES	No Odor

830.6313	Stability to normal and elevated temperatures, metals and metal
ions	41610001, 4237801	YES

	830.7000	pH	41610001, 4237801	YES

	830.7050	UV/VIS absorption

No	* Data Gap

830.7200	Melting Point/Melting Range	41789501	YES

	830.7220	Boiling Point/Boiling Point Range	See guideline   830.7200

830.7300	Density/Relative Density/Bulk Density	42451101	YES

	830.7370	Dissociation  Constant	41610001	Yes

	830.7550	Partition coefficient (n-octanol /water) shake flask method

No

	* Data Gap

830.7560	Partition coefficient (n-octanol /water) generator column
method

	830.7570	Partition coefficient (n-octanol /water) estimation by liquid
chromatography

	830.7840	Water Solubility: Column Elution Method; Shake Flask Method
41610001	Yes

	830.7860	Water solubility, generator column method	See guideline  
830.7840

830.7950	Vapor pressure	41610001,

41651901	YES

	

Case No. 2395

Case Name:  Methanearsonic acid salts

Registrant:  GB Biosciences Corporation

Product(s):  59% MSMA T 

	PRODUCT CHEMISTRY DATA SUMMARY

Table 6.   Product Chemistry Data Summary for Mono Sodium
Methanearsonic salt   SEQ CHAPTER \h \r 1 

OPPTS Guideline Numbers	GB Biosciences Corporation

Data Requirements: MSMA 59% [Technical]

PC Code: 013803

CAS No.: 2163-80-6	Master Record Identification [MRID] 	

Data Requirements Fulfilled	

Results 

or 

*Data Gap

830.1550	Product Identity and Composition  	42153501	Yes

	830.1600

	Description of Materials Used to Produce the Product	42081201	Yes

	830.1620	Description of Production Process	42081201	Yes

	830.1650	Description of Formulation Process

No	*Data Gap

830.1670	Discussion of Formation of Impurities	41608101	Yes

	830.1700	Preliminary Analysis	41608101	Yes

	830.1750	Certified Limits

No	*Data Gap

830.1800	Enforcement Analytical Method

No	*Data Gap

830.1900	Submittal of Samples

No	*Data Gap

830.6302	Color

No	*Data Gap

830.6303	Physical State

No	*Data Gap

830.6304	Odor

No	*Data Gap

830.6313	Stability to normal and elevated temperatures, metals and metal
ions	41610001, 42378601	Yes

	830.7000	pH

No	*Data Gap

830.7050	UV/VIS absorption

No	*Data Gap

830.7200	Melting Point/Melting Range	41789501	Yes

	830.7220	Boiling Point/Boiling Point Range	See guideline 830.7200

830.7300	Density/Relative Density/Bulk Density

No	*Data Gap

830.7370	Dissociation  Constant	41610001	Yes

	830.7550	Partition coefficient (n-octanol /water) shake flask method

No

	*Data Gap

830.7560	Partition coefficient (n-octanol /water) generator column
method

	830.7570	Partition coefficient (n-octanol /water) estimation by liquid
chromatography

	830.7840	Water Solubility: Column Elution Method; Shake Flask Method
41610001	Yes

	830.7860	Water solubility, generator column method	See guideline
830.7840

830.7950	Vapor pressure	41610001, 41651901	Yes

	

AGENCY MEMORANDA CITED IN THIS DOCUMENT

CBRS No(s):	8155

DP Barcode(s):	D165463

Subject:		Monosodium methanearsonate (MSMA):  (ID# 013803-042519);
Luxembourg-Pamol, Inc.:  Response to MSMA (Case No. 2395, Chemical No.
13803) Phase 4 Reregistration Product Chemistry Data Requirements
(Regarding Melting Point Guideline #63-5).

From:		F. Toghrol

To:			B. Briscoe

Dated:		11/20/91

MRID(s):		41789501

CBRS No(s):	RD Memorandum

DP Barcode(s):	D170330

Subject:		Product Chemistry Review of ISK Biotech Disodium
Methanearsonate (EPA Reg. No. 50534-39); Action Code 345.

From:		M. Getz

To:			C. Giles-Parker

Dated:		12/26/91

MRID(s):		42051902

CBRS No(s):	8931

DP Barcode(s):	D171424

Subject:		Reregistration of Monosodium Methanearsonate.  ISK Biotech
Corp.  Product Chemistry. 

From:		S. Funk

To:			B. Crompton

Dated:		1/13/92

MRID(s):		42081201

CBRS No(s):	8810

DP Barcode(s):	D170296

Subject:		Reregistration of Disodium Methanearsonate.  Luxembourg-Pamol,
Inc.  Response to Phase 4 Review.

From:		S. Funk

To:			B. Crompton

Dated:		1/13/92

MRID(s):		41982001, 41976201, and 41976202

CBRS No(s):	8811

DP Barcode(s):	D170285

Subject:		Reregistration of Monosodium Methanearsonate. 
Luxembourg-Pamol, Inc.  Response to Phase 4 Review of Product Chemistry.

From:		S. Funk

To:			B. Crompton

Dated:		1/13/92

MRID(s):		41651901

CBRS No(s):	8916

DP Barcode(s):	D170574

Subject:		Reregistration of Disodium Methanearsonate.  APC Holdings
(Inter-Ag) Response to Phase 4 Review of Product Chemistry.

From:		S. Funk

To:			B. Crompton

Dated:		1/13/92

MRID(s):		42053701 and 42053702

CBRS No(s):	8916 (Addendum)

DP Barcode(s):	D170574 (Addendum)

Subject:		Reregistration of Disodium Methanearsonate (DSMA).  APC
Holdings (Inter-Ag) Response to Phase 4 Review of Product Chemistry. 
Addendum to Memorandum of 1/13/92.

From:		S. Funk

To:			B. Crompton

Dated:		3/11/92

MRID(s):		42053701

CBRS No(s):	8473

DP Barcode(s):	D168029

Subject:		Disodium methanearsonate (DSMA):  (ID# 013802-042519);
Luxembourg-Pamol, Inc.:  Response to DSMA (Case No. 2395, Chemical No.
013802) Reregistration Product Chemistry Data Requirements (Regarding
Melting Point & pH Guideline # 63-5 & 63-12).

From:		F. Toghrol

To:			B. Briscoe

Dated:		7/6/92

MRID(s):		41982002

CBRS No(s):	8526

DP Barcode(s):	D167786

Subject:		Disodium methanearsonate (DSMA):  (ID# 013802-042519);
Luxembourg-Pamol, Inc:  Response to DSMA (Case No. 2395, Chemical No.
013802) Reregistration Product Chemistry Data Requirements (Regarding
Dissociation Constant, Octanol/Water Partition Coefficient, and
Stability (Guideline # 63-10, 63-11, & 63-13)).

From:		F. Toghrol

To:			B. Briscoe

Dated:		7/6/92

MRID(s):		41976203

CBRS No(s):	10535

DP Barcode(s):	D182274

Subject:		Reregistration of Monosodium Methanearsonate (MSMA). 
Luxembourg-Pamol, Inc.  Product Chemistry {Guideline 63}.  (Case No.
2395, Chemical No. 13803).

From:		D. McNeilly

To:			B. Crompton

Dated:		10/26/92

MRID(s):		42451101

CBRS No(s):	10542

DP Barcode(s):	D182275

Subject:		DSMA (Disodium Methanearsonate) Reregistration.  Product
Chemistry Guideline 63-7:  Bulk Density or Specific Gravity.  Response
to Phase IV Review and 63 Series Status Report.

From:		A. Aikens

To:			B. Briscoe/B. Crompton

Dated:		10/27/92

MRID(s):		42451102

CBRS No(s):	9143, 10156, and 10216

DP Barcode(s):	D172598, D180025, and D180715

Subject:		DSMA Reregistration:  a List B Chemical (Chemical No.: 
013802; Case No. 2395).  Registrants Response to the DSMA Product
Chemistry Data Requirements.

From:		F. Toghrol

To:			L. Rossi/B. Briscoe

Dated:		2/8/93

MRID(s):		42388301, 42388302, 42361001, and 42120701

CBRS No(s):	10527

DP Barcode(s):	D182420

Subject:		Monosodium methanearsonate (MSMA):  Luxembourg-Pamol, Inc. 
Response to MSMA (Case No. 2395; Chemical No. 013803) Reregistration
Product Chemistry Data Requirements (Regarding Guideline # 61-1,
61-2(a), & 62-1 to 62-3).

From:		F. Toghrol

To:			B. Briscoe

Dated:		2/9/93

MRID(s):		42387801 and 42387802

CBRS No(s):	10254

DP Barcode(s):	D180533

Subject:		MSMA (Methanearsonic Acid and Salts):  MAA Research Task Force
Three.  Response to the Phase IV Review dated (3/28/91):  Product
Chemistry Guidelines 63-12 and 63-13.  (Chemical No. 013803)

From:		A. Aikens

To:			B. Briscoe/B. Crompton

Dated:		2/22/93

MRID(s):		42378601

CBRS No(s):	10622

DP Barcode(s):	D182871

Subject:		Monosodium methanearsonate (MSMA) Reregistration:  a List B
Chemical.  APC Holdings, Inc. Response to MSMA (Case No. 2395, Chemical
No. 013803) Reregistration Product Chemistry Data Requirements
(Regarding Guideline # 61-2 & 62-1).

From:		F. Toghrol

To:			B. Briscoe

Dated:		2/25/93

MRID(s):		41702001, 41702002, and 42474101

DP Barcode(s):	D235020

Subject:		MSMA and DSMA; EPA Reg. Nos. 42519-1 and -7.  PC Codes 013801
and 013802.  List B Reregistration Case 2395.  Supplemental Product
Chemistry.

From:		K. Dockter

To:			L. Werrell

Dated:		5/17/99

MRID(s):		41602502, 41602701, 41610001, 42387801, and 42451102

DP Barcode(s):	D265640

Subject:		Product Chemistry Review of Luxembourg-Pamol DSMA 81% EP;
Revised Manufacturing Process.

From:		

To:			

Dated:		Currently under review

MRID(s):		44150401

PRODUCT CHEMISTRY CITATIONS

Bibliographic citations include only MRIDs containing data which fulfill
data requirements. 

References (cited):

41602502  Pesselman, R. (1990) Solvent Solubility Determination of
Methanearsonate (DSMA):  Final Report:  Lab Project Number:  6001-577. 
Unpublished study prepared by Hazleton Laboratories America, Inc.  41 p.

41602701  MAA Research Task Force. (1990) MSMA 6.6:  Product Identity
and Composition.  Unpublished study.  9 p.

41608101  Peplowski, M. (1990) Product Identity and Disclosure of
Ingredients:  Arsonate Liquid/Ansar 6.6 (MSMA).  Unpublished study by
Fermenta ASC Corp.  7 p.

41608104  Mizner, D. (1990) Ansar 6.6 Preliminary Analyses:  Lab Project
Number:  PC-90-MAP-001.  Unpublished study prepared by Fermenta ASC
Corp.  9 p.

41608107  Fraley, R. (1990) Determination of Physical and Chemical
Characteristics of Arsonate Liquid/Ansar 6.6 (MSMA):  Lab Project
Number:  PC-90-RWF-001-01; PC-90-RWF-002-01; PC-90-RWF-003-01. 
Unpublished study prepared by Fermenta ASC Corp., Formulation Lab.  115
p.

41610001  MAA Research Task Force Three (1990) MSMA 6.6:  Physical and
Chemical Characteristics:  Final Reports:  Lab Project Number:  
1081-89-0355-AS-001; HLA 6001-575.  Unpublished study.  234 p.

41651901  Lorence, P. (1989) Monomethylarsonic Acid.  Determination of
Vapor Pressure.  Unpublished study prepared by Fermenta ASC Corp. 50 p.

41702001  Haefele, L. (1990) Product Identity and Composition:  MSMA
660.  Unpublished study prepared by Drexel Chemical Co.  24 p.

41702002  Haefele, L. (1990) Analysis and Certification of Ingredient
Limits - MSMA 660.  Unpublished study prepared by Drexel Chemical Co. 18
p.

41789501  Pesselman, R. (1991) Melting Point/Melting Range
Determination of Synthetically Prepared Monosodium Methanearsonate
(MSMA): LabProject Number: HWI 6001-685.  Unpublished study prepared by
Hazleton Wisconsin, Inc.  23 p.

41976201  Pesselman, R. (1991) Dissociation Constant Determination of
DSMA Lab Project Number:  6366-102.  Unpublished study prepared by
Hazleton Wisconsin, Inc.  35 p.

41976202  Pesselman, R. (1991) Octanol/Water Partition Coefficient
Determination of DSMA: Lab Project Number:  6366-101.  Unpublished study
prepared by Hazleton Wisconsin, Inc.  39 p.

41976203  Pesselman, R. (1991) Stability Determination of DSMA:  Lab
Project Number: 6366-105.  Unpublished study prepared by Hazleton
Wisconsin, Inc.  35 p.

41982001  Pesselman, R. (1991) Melting Point/Melting Range Determination
DSMA:  Final Report:  Lab Project Number:  HWI 6366-104.  Unpublished
study prepared by Hazleton Wisconsin, Inc.  21 p.

41982002  Pesselman, R. (1991) Ph Value Determination of DSMA:  Final
Report:  Lab Project Number:  HWI-6366-100.  Unpublished study prepared
by Hazleton Wisconsin, Inc.  19 p.

42051902  Owens, E. (1991) Product Identity and Disclosure of
Ingredients Disodium Methanearsonate Technical Grade (DSMA). 
Unpublished study prepared by ISK Biotech Corp.  7 p.

42053701  Haefele, L. (1991) Product Identity and Compostion: DSMA
Products.  Unpublished study prepared by Drexel Chemical Co.  25 p.

42053702  Haefele, L. (1991) Analysis and Certification of Ingredient
Limits:  DSMA Products.  Unpublished study prepared by Drexel Chemical
Co.  18 p.

42081201 Lightsey, D. (1991) Description of Starting Materials and
Manufacturing Process for Arsonate Liquid. Amendment #1.  Unpublished
study prepared by ISK Biotech 12p.

42120701  Pesselman, R. (1991) Vapor Pressure Determination of DSMA: 
Lab Project Number:  HWI 6366-103.  Unpublished study prepared by
Hazleton Wisconsin, Inc.  36 p.

42153501  Owens, E. (1991) Confidential Statement of Formulation: 
Arsonate Liquid/Ansar 6. 6 (MSMA)/Daconate Super.  Unpublished study
prepared by ISK Biotech Corp.  6 p.

42361001  Haefele, L. (1992) Supplement to Product Chemistry--DSMA 
Products.  Unpublished study prepared by Drexel Chemical Co. 13 p.

42378601  Pesselman, R. (1992) Final Report:  Series 63 Product
Chemistry Determinations of Monosodium Methanearsonate, MSMA (pH and
Stability):  Lab Project Number:  6366-108.  Unpublished study prepared
by Hazleton Wisconsin, Inc.  34 p.

42387801  Bellet, E. (1992) Target 6.6:  Product Identity and
Composition.  Unpublished study prepared by Chemical Consultants
International, Inc.  9 p.

42387802  Bellet, E. (1992) Target 6. 6:  Analytical Methods. 
Unpublished study prepared by Chemical Consultants International, Inc. 
11 p.

42388301  Bellet, E. (1992) DSMA 81 P:  Product Identity and
Composition.  Unpublished study prepared by Chemical Consultants
International.  9 p.

42388302  Bellet, E. (1992) DSMA 81 P:  Analytical Methods.  Unpublished
study prepared by Chemical Consultants International, Inc.  10 p.

42451101  Bellet, E. (1992) Target 6.6:  Physical and Chemical
Characteristics.  Unpublished study prepared by Consultants Intl., Inc. 
6 p.

42451102  Bellet, E. (1992) DSMA 81 P:  Physical and Chemical
Characteristics.  Unpublished study prepared by Chemical Consultants,
Inc.  5 p.

42474101  Haefele, L. (1992) Supplement to Product Chemistry:  MSMA  
Unpublished study prepared by Drexel Chemical Co.  11 p.

44150401  Eldan, M., comp. (1996) Revised Manufacturing Process and
Discussion of Impurities for DSMA 81P.  Unpublished study prepared by
Chemical Consultants International, Inc.  7 p.

 PAGE   

 PAGE   1