Document ID: EPA-HQ-OPP-2008-0352-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2009-09-11T04:00Z

SEQ CHAPTER \h \r 1 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF PREVENTION, PESTICIDES,

                                                                        
                  AND TOXIC SUBSTANCES

	

MEMORANDUM

Date:  		02-JUN-2009

SUBJECT:	Saflufenacil.  Acute and Chronic Aggregate Dietary (Food and
Drinking Water) Exposure and Risk Assessment for the Section 3
Registration Action in/on Legume Vegetables (Crop Group 06), the Foliage
of Legume Vegetables (Crop Group 07), Citrus Fruits (Crop Group 10),
Pome Fruits (Crop Group 11), Stone Fruits (Crop Group 12), Tree Nuts
(Crop Group14), Cereal Grains (Crop Group 15), Forage, Fodder and Straw
of Cereal Grains (Crop Group 16), Grapes, Cotton, Sunflower, and
Livestock Commodities.

PC Code:  118203	DP Barcode:  D364183

Decision No.:  389161	Registration Nos.:  7969-ETA, 7969-ETI, 7969-ETO,
7969-EIN

Petition No.:  8F7322	Regulatory Action:  Sec. 3 Registration

Risk Assessment Type:  Dietary	Case No.:  NA

TXR No.:  NA	CAS No.:  372137-35-4

MRID Nos.: NA	40 CFR:  §180.xxx

FROM:	George F. Kramer, Ph.D., Senior Chemist

Risk Assessment Branch 1 (RAB1)/Health Effects Division (HED; 7509P)

THROUGH:	Mohsen Sahafeyen, Chemist, RAB6/HED

P. Yvonne Barnes, Biologist, Reregistration Branch 2 (RAB6)/HED

Dietary Exposure Science Advisory Council (DESAC)

HED (7509P)

and

Dana M. Vogel, Branch Chief

RAB1/HED (7509P)

TO:		Lisa Austin, Ph.D., Toxicologist

		RAB1/HED (7509P)

and

Kathryn Montague/Joanne Miller, PM Team 23

Registration Division (RD) (7505P)

Executive Summary

Acute and chronic dietary-exposure and risk assessments were conducted
using the Dietary Exposure Evaluation Model software with the Food
Commodity Intake Database (DEEM-FCID™, Version 2.03) which use food
consumption data from the U.S. Department of Agriculture’s Continuing
Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998. 
These analyses was performed to support a Section 3 request for the use
of saflufenacil in/on legume vegetables (group 06), citrus fruits (group
10), pome fruits (group 11), stone fruits (group 12), tree nuts
(group14), cereal grains (group 15), grapes, and sunflower.  

Acute Dietary (Food and Drinking Water) Exposure Results and
Characterization

The unrefined acute analysis assumed 100% crop treated (CT), DEEM™
7.81 default concentration factors, and tolerance-level residues for all
commodities.  Drinking water was incorporated directly into the dietary
assessment using the concentration for ground water generated by the
Tier II Pesticide Root Zone Model Ground Water (PRZM GW).  The acute
dietary exposure and risk estimates (food + water) are 0.010051
mg/kg/day for the general U.S. population (<1% of the acute
population-adjusted dose (aPAD)) and 0.036991 mg/kg/day (<1% of the
aPAD) for the most highly exposed population subgroup (all infants (<1
year old)) and are thus below HED’s level of concern (<100% aPAD).

Chronic Dietary (Food and Drinking Water) Exposure Results and
Characterization

The unrefined chronic analysis assumed 100% CT, DEEM™ 7.81 default
concentration factors, and tolerance-level residues for all commodities.
 Drinking water was incorporated directly into the dietary assessment
using the concentration for ground water generated by PRZM GW.  The
chronic dietary exposure and risk estimates (food + water) are 0.004043
mg/kg/day for the general U.S. population (8.8% of the chronic
population-adjusted dose (cPAD)) and 0.012951 mg/kg/day (28% of the
cPAD) for the most highly exposed population subgroup (all infants (<1
year old)) and are thus below HED’s level of concern (<100% cPAD).

Cancer Dietary (Food and Drinking Water) Exposure Results and
Characterization

Saflufenacil is classified as “not likely carcinogenic to humans.” 
Therefore, cancer risk is not a concern for this chemical.

I.  Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population-adjusted dose
(PAD).  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL,
i.e.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  HED is generally
concerned when estimated cancer risk exceeds one in one million. 
References which discuss the acute and chronic risk assessments in more
detail are available on the EPA/pesticides web site:  “Available
Information on Assessing Exposure from Pesticides, A User’s Guide,”
21-JUN-2000, web link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see
SOP 99.6 (20-AUG-1999).

Saflufenacil is a new active ingredient.  Therefore, this document
presents the first dietary risk assessment for saflufenacil conducted by
HED.

II.  Residue Information

Saflufenacil Proposed and Registered Uses:

Residues of Concern:  The nature of the residue in plants (resulting
from preplant/preemergence application), rotational crops, and livestock
is adequately understood based on acceptable metabolism studies
conducted on corn, soybean, tomato, rotational crops, lactating goats,
and laying hens.  The residues of concern for the tolerance expression
and risk assessment are shown in Table 1 (Memo, B. Daiss, 01/06/09;
D359645).  

Table 1.  Summary of Metabolites and Degradates to be included in the
Risk Assessment.

Matrix	Residues included in Risk Assessment	Residues included in
Tolerance Expression

Plants	Primary Crops	Saflufenacil + M800H11, M800H35	Saflufenacil +
M800H11, M800H35

	Rotational Crops

Livestock	Ruminants	Saflufenacil	Saflufenacil

	Poultry

Drinking Water	Saflufenacil + M800H01, M800H02, M800H07, M800H08,
M800H15, M800H22, Product 8	Not Applicable

Established Tolerances:  There are currently no established U.S.
tolerances for residues of saflufenacil.

Recommended Tolerances:  Based on the residue chemistry data submitted
with the current petition, HED recommended for establishment of the
following crop tolerances for combined residues saflufenacil plus
metabolites M800H11 and M800H35, calculated as saflufenacil equivalents
and livestock tolerances, expressed as parent only (G. Kramer, 06/04/09;
DP# 349938):

Table 2.  Tolerance Summary for Saflufenacil.

Commodity	Recommended Tolerance (ppm)

Vegetable, legume, group 6	0.03

Vegetable, foliage of legume, group 7	0.10

Fruit, citrus, group 10	0.03

Fruit, pome, group 11	0.03

Fruit, stone, group 12	0.03

Nut, tree, group 14	0.03

Almond, hulls	0.10

Grain, cereal, group 15	0.03

Grain, cereal, forage, fodder and straw group 16	0.10

Cotton, undelinted seed	0.03

Cotton, gin byproducts	0.10

Sunflower, seed	1.0

Grape	0.03

Milk	0.01

Cattle, meat	0.01

Cattle, fat	0.01

Cattle, liver	0.80

Cattle, meat byproducts, except liver	0.02

Goat, meat	0.01

Goat, fat	0.01

Goat, liver	0.80

Goat, meat byproducts, except liver	0.02

Hog, meat	0.01

Hog, fat	0.01

Hog, liver	0.80

Hog, meat byproducts, except liver	0.02

Sheep, meat	0.01

Sheep, fat	0.01

Sheep, liver	0.80

Sheep, meat byproducts, except liver	0.02

Horse, meat	0.01

Horse, fat	0.01

Horse, liver	0.80

Horse, meat byproducts, except liver	0.02

Residue Data used for Acute and Chronic Assessments:

The acute and chronic analyses assumed 100% CT, DEEM™ 7.81 default
concentration factors, and tolerance-level residues for all commodities.

  Drinking Water Data

™ into the food categories “water, direct, all sources” and
“water, indirect, all sources.”

Screening EDWCs (Table 3) of saflufenacil were generated with FQPA Index
Reservoir Screening Tool (FIRST) for surface water and with PRZM GW for
ground water.  Modeled application rates represent the maximum use
patterns of five proposed end-use labels with selected uses on row
crops, orchard trees, vineyards, tree plantations, and non-agricultural
areas.  Remaining model input parameters were chosen according to
current guidance (USEPA, 2002).  EDWCs reflect exposure to saflufenacil
and all degradates of concern in drinking water (Table 1).  

Table 3.  Tiered EDWCs for Proposed Saflufenacil Uses.

Source (Tier: Model)	1-in-10-year Peak Exposure (ppb)	1-in-10-year
Annual Mean Exposure (ppb) 

Surface water (Tier I: FIRST)	37.3	23.8

Ground water (Tier II: PRZM GW)	180

(used in acute analysis)	173

(used in chronic analysis)

IV.  DEEM-FCID™ Program and Consumption Information

Saflufenacil acute and chronic dietary exposure assessments were
conducted using DEEM-FCID™, Version 2.03, which incorporates
consumption data from USDA’s CSFII, 1994-1996 and 1998.  The 1994-96,
98 data are based on the reported consumption of more than 20,000
individuals over two non-consecutive survey days.  Foods “as
consumed” (i.e., apple pie) are linked to EPA-defined food commodities
(i.e. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicly available recipe
translation files developed jointly by USDA/ARS and EPA.  For chronic
exposure assessment, consumption data are averaged for the entire U.S.
population and within population subgroups, but for acute exposure
assessment are retained as individual consumption events.  Based on
analysis of the 1994-96, 98 CSFII consumption data, which took into
account dietary patterns and survey respondents, HED concluded that it
is most appropriate to report risk for the following population
subgroups: the general U.S. population, all infants (<1 year old),
children 1-2 years old, children 3-5 years old, children 6-12 years old,
youth 13-19 years old, females 13-49 years old, adults 20-49 years old,
and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (i.e., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., only those who reported
eating relevant commodities/food forms) and a per-capita (i.e., those
who reported eating the relevant commodities as well as those who did
not) basis.  In accordance with HED policy, per capita exposure and risk
are reported for all tiers of analysis.  However, for Tiers 1 and 2, any
significant differences in user vs. per capita exposure and risk are
specifically identified and noted in the risk assessment.

V.  Toxicological Information

Table 4.  Summary of Toxicological Doses and Endpoints for saflufenacil
for Use in Dietary Human Health Risk Assessments.

Exposure/

Scenario	Point of Departure	Uncertainty/

FQPA SFs	RfD, PAD, LOC for Risk Assessment	Study and Toxicological
Effects

Acute Dietary (General Population, including Infants and Children)	NOAEL
= 500 mg/kg/day

	UFA = 10X

UFH = 10X

FQPA SF = 1X	Acute RfD =

5.0 mg/kg

aPAD = 5.0 mg/kg	Acute Neurotoxicity Study

NOAEL = 500 (M) and 2000 (F) mg/kg/day.

LOAEL was 2000 mg/kg/day (males) based on the decreased motor activity
representing mild and transient systemic toxicity. 

LOAEL was not established for females.

Chronic Dietary (All Populations)	NOAEL = 4.6 mg/kg/day

 	UFA = 10X

UFH = 10X

FQPA SF = 1X

	Chronic RfD = 0.046 mg/kg/day

cPAD = 0.046 mg/kg/day	Chronic/Carcinogenicity (mouse)

NOAEL = 4.6 mg/kg bw/d (males) and 18.9 mg/kg bw/d (females). 

LOAELs = 13.8 mg/kg bw/d (males) and 38.1 mg/kg bw/day (females) based
on decreased red blood cells, hemoglobin, and hematocrit and porphyria
observed in the satellite group.

Cancer (oral, dermal, inhalation)	Classification:  Not carcinogenic
based on the lack of tumors in the mouse and rat carcinogenicity studies
and lack of mutagenicity.

NOAEL = no-observed adverse-effect level.  LOAEL = lowest-observed
adverse-effect level.  UF = uncertainty factor.  UFA = extrapolation
from animal to human (interspecies).  UFH = potential variation in
sensitivity among members of the human population (intraspecies).  FQPA
SF = FQPA Safety Factor.  PAD = population-adjusted dose (a = acute, c =
chronic).  RfD = reference dose.  LOC = level of concern.

VI.  Results/Discussion 

™ analyses estimate the dietary exposure of the U.S. population and
various population subgroups.  The results reported in Table 3 are for
the general U.S. population, all infants (<1 year old), children 1-2
years old, children 3-5 years old, children 6-12 years old, youth 13-19
years old, females 13-49 years old, adults 20-49 years old, and adults
50+ years old. 

 

Results of Acute and Chronic Dietary Exposure Analyses

The acute dietary exposure for food and drinking water utilized (<1% of
the aPAD for the U.S. population.  The acute dietary exposure for the
highest exposed population subgroup, all infants (<1 year old), is <1%
of the aPAD.

The chronic dietary exposure for food and drinking water utilized 8.8%
of the cPAD for the U.S. population.  The chronic dietary exposure for
the highest exposed population subgroup, all infants (<1 year old), is
28% of the cPAD.  

The results of the acute and chronic dietary exposure analyses are
reported in Table 5.  



Table 5.  Summary of Dietary (Food and Drinking Water) Exposure Risk for
Saflufenacil.

Population Subgroup	Acute Dietary

(95th Percentile)	Chronic Dietary

	Dietary Exposure (mg/kg/day)	% aPAD	Dietary Exposure

(mg/kg/day)	% cPAD

General U.S. Population	0.010051	<1	0.004043	8.8

All Infants (<1 year old)	0.036991	<1	0.012951	28

Children 1-2 years old	0.016375	<1	0.006895	15

Children 3-5 years old	0.014835	<1	0.006176	13

Children 6-12 years old	0.010181	<1	0.004141	9.0

Youth 13-19 years old	0.008192	<1	0.003002	6.5

Adults 20-49 years old	0.009009	<1	0.003672	8.0

Adults 50+ years old	0.008151	<1	0.003821	8.3

Females 13-49 years old	0.009122	<1	0.003659	8.0

*The values for the highest exposed population for each type of risk
assessment are bolded.

VII.  Characterization of Inputs/Outputs

These acute and chronic dietary exposure and risk estimates are
conservative since they assumed 100% CT, DEEM™ 7.81 default
concentration factors, and tolerance-level residues and were based on
screening level estimates of drinking water concentrations generated by
PRZM GW.  They could be further refined through the use of anticipated
residues, empirical processing factors and % CT data, as well as refined
drinking water estimates.

VIII.  Conclusions

™ indicates that dietary risks to saflufenacil from food and drinking
water is well below HED’s levels of concern for this pesticide. 
Estimated acute dietary risks are <1% of the aPAD for the general U.S.
population and all population subgroups and estimated chronic dietary
risks are ≤28% of the cPAD for the general U.S. population and all
population subgroups.  

IX.  List of Attachments

Acute Food plus Water Residue Input File.

Acute Results File.

Chronic Food plus Water Residue Input File.

Chronic Results File.

cc:  G. Kramer (RAB1)

RDI:  M. Sahafeyen (5/12/09), Y. Barnes (6/2/09)

G.F. Kramer:S10781:PY-S:(703)305-5079:7509P:RAB1

Acute Food plus Water Residue Input File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for SAFLUFENACIL                      
1994-98 data

Residue file: C:\Documents and Settings\gkramer\My
Documents\GK\%Saflufenacil\Saflufenacil_Acute.R98

                                                           Adjust. #2
NOT used

Analysis Date 04-17-2009             Residue file dated:
04-16-2009/13:35:15/8

Reference dose (RfD) = 0.046 mg/kg bw/day

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

14000030 14   Almond                             0.030000   1.000     
1.000   

14000031 14   Almond-babyfood                    0.030000   1.000     
1.000   

14000040 14   Almond, oil                        0.030000   1.000     
1.000   

14000041 14   Almond, oil-babyfood               0.030000   1.000     
1.000   

11000070 11   Apple, fruit with peel             0.030000   1.000     
1.000   

11000080 11   Apple, peeled fruit                0.030000   1.000     
1.000   

11000081 11   Apple, peeled fruit-babyfood       0.030000   1.000     
1.000   

11000090 11   Apple, dried                       0.030000   1.000     
8.000   

11000091 11   Apple, dried-babyfood              0.030000   1.000     
8.000   

11000100 11   Apple, juice                       0.030000   1.000     
1.300   

11000101 11   Apple, juice-babyfood              0.030000   1.000     
1.300   

11000110 11   Apple, sauce                       0.030000   1.000     
1.000   

11000111 11   Apple, sauce-babyfood              0.030000   1.000     
1.000   

12000120 12   Apricot                            0.030000   1.000     
1.000   

12000121 12   Apricot-babyfood                   0.030000   1.000     
1.000   

12000130 12   Apricot, dried                     0.030000   1.000     
6.000   

12000140 12   Apricot, juice                     0.030000   1.000     
1.000   

12000141 12   Apricot, juice-babyfood            0.030000   1.000     
1.000   

15000250 15   Barley, pearled barley             0.030000   1.000     
1.000   

15000251 15   Barley, pearled barley-babyfood    0.030000   1.000     
1.000   

15000260 15   Barley, flour                      0.030000   1.000     
1.000   

15000261 15   Barley, flour-babyfood             0.030000   1.000     
1.000   

15000270 15   Barley, bran                       0.030000   1.000     
1.000   

06030300 6C   Bean, black, seed                  0.030000   1.000     
1.000   

06020310 6B   Bean, broad, succulent             0.030000   1.000     
1.000   

06030320 6C   Bean, broad, seed                  0.030000   1.000     
1.000   

06020330 6B   Bean, cowpea, succulent            0.030000   1.000     
1.000   

06030340 6C   Bean, cowpea, seed                 0.030000   1.000     
1.000   

06030350 6C   Bean,  great northern, seed        0.030000   1.000     
1.000   

06030360 6C   Bean, kidney, seed                 0.030000   1.000     
1.000   

06020370 6B   Bean, lima, succulent              0.030000   1.000     
1.000   

06030380 6C   Bean, lima, seed                   0.030000   1.000     
1.000   

06030390 6C   Bean, mung, seed                   0.030000   1.000     
1.000   

06030400 6C   Bean, navy, seed                   0.030000   1.000     
1.000   

06030410 6C   Bean, pink, seed                   0.030000   1.000     
1.000   

06030420 6C   Bean, pinto, seed                  0.030000   1.000     
1.000   

06010430 6A   Bean, snap, succulent              0.030000   1.000     
1.000   

06010431 6A   Bean, snap, succulent-babyfood     0.030000   1.000     
1.000   

21000440 M    Beef, meat                         0.010000   1.000     
1.000   

21000441 M    Beef, meat-babyfood                0.010000   1.000     
1.000   

21000450 M    Beef, meat, dried                  0.010000   1.000     
1.920   

21000460 M    Beef, meat byproducts              0.020000   1.000     
1.000   

21000461 M    Beef, meat byproducts-babyfood     0.020000   1.000     
1.000   

21000470 M    Beef, fat                          0.010000   1.000     
1.000   

21000471 M    Beef,fat-babyfood                  0.010000   1.000     
1.000   

21000480 M    Beef, kidney                       0.010000   1.000     
1.000   

21000490 M    Beef, liver                        0.800000   1.000     
1.000   

21000491 M    Beef, liver-babyfood               0.800000   1.000     
1.000   

14000590 14   Brazil nut                         0.030000   1.000     
1.000   

15000650 15   Buckwheat                          0.030000   1.000     
1.000   

15000660 15   Buckwheat, flour                   0.030000   1.000     
1.000   

14000680 14   Butternut                          0.030000   1.000     
1.000   

14000810 14   Cashew                             0.030000   1.000     
1.000   

12000900 12   Cherry                             0.030000   1.000     
1.000   

12000901 12   Cherry-babyfood                    0.030000   1.000     
1.000   

12000910 12   Cherry, juice                      0.030000   1.000     
1.500   

12000911 12   Cherry, juice-babyfood             0.030000   1.000     
1.500   

14000920 14   Chestnut                           0.030000   1.000     
1.000   

06030980 6C   Chickpea, seed                     0.030000   1.000     
1.000   

06030981 6C   Chickpea, seed-babyfood            0.030000   1.000     
1.000   

06030990 6C   Chickpea, flour                    0.030000   1.000     
1.000   

10001060 10   Citrus citron                      0.030000   1.000     
1.000   

10001070 10   Citrus hybrids                     0.030000   1.000     
1.000   

10001080 10   Citrus, oil                        0.030000   1.000     
1.000   

15001200 15   Corn, field, flour                 0.030000   1.000     
1.000   

15001201 15   Corn, field, flour-babyfood        0.030000   1.000     
1.000   

15001210 15   Corn, field, meal                  0.030000   1.000     
1.000   

15001211 15   Corn, field, meal-babyfood         0.030000   1.000     
1.000   

15001220 15   Corn, field, bran                  0.030000   1.000     
1.000   

15001230 15   Corn, field, starch                0.030000   1.000     
1.000   

15001231 15   Corn, field, starch-babyfood       0.030000   1.000     
1.000   

15001240 15   Corn, field, syrup                 0.030000   1.000     
1.500   

15001241 15   Corn, field, syrup-babyfood        0.030000   1.000     
1.500   

15001250 15   Corn, field, oil                   0.030000   1.000     
1.000   

15001251 15   Corn, field, oil-babyfood          0.030000   1.000     
1.000   

15001260 15   Corn, pop                          0.030000   1.000     
1.000   

15001270 15   Corn, sweet                        0.030000   1.000     
1.000   

15001271 15   Corn, sweet-babyfood               0.030000   1.000     
1.000   

95001280 O    Cottonseed, oil                    0.030000   1.000     
1.000   

95001281 O    Cottonseed, oil-babyfood           0.030000   1.000     
1.000   

11001290 11   Crabapple                          0.030000   1.000     
1.000   

14001550 14   Filbert                            0.030000   1.000     
1.000   

14001560 14   Filbert, oil                       0.030000   1.000     
1.000   

23001690 M    Goat, meat                         0.010000   1.000     
1.000   

23001700 M    Goat, meat byproducts              0.020000   1.000     
1.000   

23001710 M    Goat, fat                          0.010000   1.000     
1.000   

23001720 M    Goat, kidney                       0.010000   1.000     
1.000   

23001730 M    Goat, liver                        0.800000   1.000     
1.000   

95001750 O    Grape                              0.030000   1.000     
1.000   

95001760 O    Grape, juice                       0.030000   1.000     
1.200   

95001761 O    Grape, juice-babyfood              0.030000   1.000     
1.200   

95001770 O    Grape, leaves                      0.030000   1.000     
1.000   

95001780 O    Grape, raisin                      0.030000   1.000     
4.300   

95001790 O    Grape, wine and sherry             0.030000   1.000     
1.000   

10001800 10   Grapefruit                         0.030000   1.000     
1.000   

10001810 10   Grapefruit, juice                  0.030000   1.000     
2.100   

06031820 6C   Guar, seed                         0.030000   1.000     
1.000   

06031821 6C   Guar, seed-babyfood                0.030000   1.000     
1.000   

14001850 14   Hickory nut                        0.030000   1.000     
1.000   

24001890 M    Horse, meat                        0.010000   1.000     
1.000   

10001970 10   Kumquat                            0.030000   1.000     
1.000   

10001990 10   Lemon                              0.030000   1.000     
1.000   

10002000 10   Lemon, juice                       0.030000   1.000     
2.000   

10002001 10   Lemon, juice-babyfood              0.030000   1.000     
2.000   

10002010 10   Lemon, peel                        0.030000   1.000     
1.000   

06032030 6C   Lentil, seed                       0.030000   1.000     
1.000   

10002060 10   Lime                               0.030000   1.000     
1.000   

10002070 10   Lime, juice                        0.030000   1.000     
2.000   

10002071 10   Lime, juice-babyfood               0.030000   1.000     
2.000   

11002100 11   Loquat                             0.030000   1.000     
1.000   

14002130 14   Macadamia nut                      0.030000   1.000     
1.000   

27002220 D    Milk, fat                          0.010000   1.000     
1.000   

27002221 D    Milk, fat - baby food/infant for   0.010000   1.000     
1.000   

27012230 D    Milk, nonfat solids                0.010000   1.000     
1.000   

27012231 D    Milk, nonfat solids-baby food/in   0.010000   1.000     
1.000   

27022240 D    Milk, water                        0.010000   1.000     
1.000   

27022241 D    Milk, water-babyfood/infant form   0.010000   1.000     
1.000   

27032251 D    Milk, sugar (lactose)-baby food/   0.010000   1.000     
1.000   

15002260 15   Millet, grain                      0.030000   1.000     
1.000   

12002300 12   Nectarine                          0.030000   1.000     
1.000   

15002310 15   Oat, bran                          0.030000   1.000     
1.000   

15002320 15   Oat, flour                         0.030000   1.000     
1.000   

15002321 15   Oat, flour-babyfood                0.030000   1.000     
1.000   

15002330 15   Oat, groats/rolled oats            0.030000   1.000     
1.000   

15002331 15   Oat, groats/rolled oats-babyfood   0.030000   1.000     
1.000   

10002400 10   Orange                             0.030000   1.000     
1.000   

10002410 10   Orange, juice                      0.030000   1.000     
1.800   

10002411 10   Orange, juice-babyfood             0.030000   1.000     
1.800   

10002420 10   Orange, peel                       0.030000   1.000     
1.000   

06022550 6B   Pea, succulent                     0.030000   1.000     
1.000   

06022551 6B   Pea, succulent-babyfood            0.030000   1.000     
1.000   

06032560 6C   Pea, dry                           0.030000   1.000     
1.000   

06032561 6C   Pea, dry-babyfood                  0.030000   1.000     
1.000   

06012570 6A   Pea, edible podded, succulent      0.030000   1.000     
1.000   

06032580 6C   Pea, pigeon, seed                  0.030000   1.000     
1.000   

06022590 6B   Pea, pigeon, succulent             0.030000   1.000     
1.000   

12002600 12   Peach                              0.030000   1.000     
1.000   

12002601 12   Peach-babyfood                     0.030000   1.000     
1.000   

12002610 12   Peach, dried                       0.030000   1.000     
7.000   

12002611 12   Peach, dried-babyfood              0.030000   1.000     
7.000   

12002620 12   Peach, juice                       0.030000   1.000     
1.500   

12002621 12   Peach, juice-babyfood              0.030000   1.000     
1.500   

11002660 11   Pear                               0.030000   1.000     
1.000   

11002661 11   Pear-babyfood                      0.030000   1.000     
1.000   

11002670 11   Pear, dried                        0.030000   1.000     
6.250   

11002680 11   Pear, juice                        0.030000   1.000     
1.000   

11002681 11   Pear, juice-babyfood               0.030000   1.000     
1.000   

14002690 14   Pecan                              0.030000   1.000     
1.000   

14002820 14   Pistachio                          0.030000   1.000     
1.000   

12002850 12   Plum                               0.030000   1.000     
1.000   

12002851 12   Plum-babyfood                      0.030000   1.000     
1.000   

12002860 12   Plum, prune, fresh                 0.030000   1.000     
1.000   

12002861 12   Plum, prune, fresh-babyfood        0.030000   1.000     
1.000   

12002870 12   Plum, prune, dried                 0.030000   1.000     
5.000   

12002871 12   Plum, prune, dried-babyfood        0.030000   1.000     
5.000   

12002880 12   Plum, prune, juice                 0.030000   1.000     
1.400   

12002881 12   Plum, prune, juice-babyfood        0.030000   1.000     
1.400   

25002900 M    Pork, meat                         0.010000   1.000     
1.000   

25002901 M    Pork, meat-babyfood                0.010000   1.000     
1.000   

25002910 M    Pork, skin                         0.010000   1.000     
1.000   

25002920 M    Pork, meat byproducts              0.020000   1.000     
1.000   

25002921 M    Pork, meat byproducts-babyfood     0.020000   1.000     
1.000   

25002930 M    Pork, fat                          0.010000   1.000     
1.000   

25002931 M    Pork, fat-babyfood                 0.010000   1.000     
1.000   

25002940 M    Pork, kidney                       0.010000   1.000     
1.000   

25002950 M    Pork, liver                        0.800000   1.000     
1.000   

10003070 10   Pummelo                            0.030000   1.000     
1.000   

11003100 11   Quince                             0.030000   1.000     
1.000   

29003120 M    Rabbit, meat                       0.010000   1.000     
1.000   

15003230 15   Rice, white                        0.030000   1.000     
1.000   

15003231 15   Rice, white-babyfood               0.030000   1.000     
1.000   

15003240 15   Rice, brown                        0.030000   1.000     
1.000   

15003241 15   Rice, brown-babyfood               0.030000   1.000     
1.000   

15003250 15   Rice, flour                        0.030000   1.000     
1.000   

15003251 15   Rice, flour-babyfood               0.030000   1.000     
1.000   

15003260 15   Rice, bran                         0.030000   1.000     
1.000   

15003261 15   Rice, bran-babyfood                0.030000   1.000     
1.000   

15003280 15   Rye, grain                         0.030000   1.000     
1.000   

15003290 15   Rye, flour                         0.030000   1.000     
1.000   

26003390 M    Sheep, meat                        0.010000   1.000     
1.000   

26003391 M    Sheep, meat-babyfood               0.010000   1.000     
1.000   

26003400 M    Sheep, meat byproducts             0.010000   1.000     
1.000   

26003410 M    Sheep, fat                         0.010000   1.000     
1.000   

26003411 M    Sheep, fat-babyfood                0.010000   1.000     
1.000   

26003420 M    Sheep, kidney                      0.010000   1.000     
1.000   

26003430 M    Sheep, liver                       0.010000   1.000     
1.000   

15003440 15   Sorghum, grain                     0.030000   1.000     
1.000   

15003450 15   Sorghum, syrup                     0.030000   1.000     
1.000   

06003470 6    Soybean, seed                      0.030000   1.000     
1.000   

06003480 6    Soybean, flour                     0.030000   1.000     
1.000   

06003481 6    Soybean, flour-babyfood            0.030000   1.000     
1.000   

06003490 6    Soybean, soy milk                  0.030000   1.000     
1.000   

06003491 6    Soybean, soy milk-babyfood or in   0.030000   1.000     
1.000   

06003500 6    Soybean, oil                       0.030000   1.000     
1.000   

06003501 6    Soybean, oil-babyfood              0.030000   1.000     
1.000   

20003640 20   Sunflower, seed                    1.000000   1.000     
1.000   

20003650 20   Sunflower, oil                     1.000000   1.000     
1.000   

20003651 20   Sunflower, oil-babyfood            1.000000   1.000     
1.000   

10003690 10   Tangerine                          0.030000   1.000     
1.000   

10003700 10   Tangerine, juice                   0.030000   1.000     
1.000   

15003810 15   Triticale, flour                   0.030000   1.000     
1.000   

15003811 15   Triticale, flour-babyfood          0.030000   1.000     
1.000   

14003910 14   Walnut                             0.030000   1.000     
1.000   

86010000 O    Water, direct, all sources         0.180000   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.180000   1.000     
1.000   

15004010 15   Wheat, grain                       0.030000   1.000     
1.000   

15004011 15   Wheat, grain-babyfood              0.030000   1.000     
1.000   

15004020 15   Wheat, flour                       0.030000   1.000     
1.000   

15004021 15   Wheat, flour-babyfood              0.030000   1.000     
1.000   

15004030 15   Wheat, germ                        0.030000   1.000     
1.000   

15004040 15   Wheat, bran                        0.030000   1.000     
1.000   

15004050 15   Wild rice                          0.030000   1.000     
1.000   

Acute Results File.

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for SAFLUFENACIL                       
(1994-98 data)

Residue file: Saflufenacil_Acute.R98                  Adjustment factor
#2 used.

Analysis Date: 04-16-2009/13:36:21    Residue file dated:
04-16-2009/13:35:15/8

Daily totals for food and foodform consumption used.

Run Comment: ""

========================================================================
=======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
--------

U.S. Population:

                    0.010051     0.20    0.018395     0.37    0.036701  
  0.73 

All infants:

                    0.036991     0.74    0.051982     1.04    0.092997  
  1.86 

Children 1-2 yrs:

                    0.016375     0.33    0.027222     0.54    0.040096  
  0.80 

Children 3-5 yrs:

                    0.014835     0.30    0.022292     0.45    0.035673  
  0.71 

Children 6-12 yrs:

                    0.010181     0.20    0.016696     0.33    0.023179  
  0.46 

Youth 13-19 yrs:

                    0.008192     0.16    0.013104     0.26    0.023368  
  0.47 

Adults 20-49 yrs:

                    0.009009     0.18    0.014796     0.30    0.026744  
  0.53 

Adults 50+ yrs:

                    0.008151     0.16    0.011642     0.23    0.019521  
  0.39 

Females 13-49 yrs:

                    0.009122     0.18    0.014496     0.29    0.025509  
  0.51 

Chronic Food plus Water Residue Input File.

 

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for SAFLUFENACIL                      
1994-98 data

Residue file: C:\Documents and Settings\gkramer\My
Documents\GK\%Saflufenacil\Saflufenacil_Chronic.R98

                                                           Adjust. #2
NOT used

Analysis Date 04-17-2009             Residue file dated:
04-16-2009/13:34:26/8

Reference dose (RfD) = 0.046 mg/kg bw/day

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

14000030 14   Almond                             0.030000   1.000     
1.000   

14000031 14   Almond-babyfood                    0.030000   1.000     
1.000   

14000040 14   Almond, oil                        0.030000   1.000     
1.000   

14000041 14   Almond, oil-babyfood               0.030000   1.000     
1.000   

11000070 11   Apple, fruit with peel             0.030000   1.000     
1.000   

11000080 11   Apple, peeled fruit                0.030000   1.000     
1.000   

11000081 11   Apple, peeled fruit-babyfood       0.030000   1.000     
1.000   

11000090 11   Apple, dried                       0.030000   1.000     
8.000   

11000091 11   Apple, dried-babyfood              0.030000   1.000     
8.000   

11000100 11   Apple, juice                       0.030000   1.000     
1.300   

11000101 11   Apple, juice-babyfood              0.030000   1.000     
1.300   

11000110 11   Apple, sauce                       0.030000   1.000     
1.000   

11000111 11   Apple, sauce-babyfood              0.030000   1.000     
1.000   

12000120 12   Apricot                            0.030000   1.000     
1.000   

12000121 12   Apricot-babyfood                   0.030000   1.000     
1.000   

12000130 12   Apricot, dried                     0.030000   1.000     
6.000   

12000140 12   Apricot, juice                     0.030000   1.000     
1.000   

12000141 12   Apricot, juice-babyfood            0.030000   1.000     
1.000   

15000250 15   Barley, pearled barley             0.030000   1.000     
1.000   

15000251 15   Barley, pearled barley-babyfood    0.030000   1.000     
1.000   

15000260 15   Barley, flour                      0.030000   1.000     
1.000   

15000261 15   Barley, flour-babyfood             0.030000   1.000     
1.000   

15000270 15   Barley, bran                       0.030000   1.000     
1.000   

06030300 6C   Bean, black, seed                  0.030000   1.000     
1.000   

06020310 6B   Bean, broad, succulent             0.030000   1.000     
1.000   

06030320 6C   Bean, broad, seed                  0.030000   1.000     
1.000   

06020330 6B   Bean, cowpea, succulent            0.030000   1.000     
1.000   

06030340 6C   Bean, cowpea, seed                 0.030000   1.000     
1.000   

06030350 6C   Bean,  great northern, seed        0.030000   1.000     
1.000   

06030360 6C   Bean, kidney, seed                 0.030000   1.000     
1.000   

06020370 6B   Bean, lima, succulent              0.030000   1.000     
1.000   

06030380 6C   Bean, lima, seed                   0.030000   1.000     
1.000   

06030390 6C   Bean, mung, seed                   0.030000   1.000     
1.000   

06030400 6C   Bean, navy, seed                   0.030000   1.000     
1.000   

06030410 6C   Bean, pink, seed                   0.030000   1.000     
1.000   

06030420 6C   Bean, pinto, seed                  0.030000   1.000     
1.000   

06010430 6A   Bean, snap, succulent              0.030000   1.000     
1.000   

06010431 6A   Bean, snap, succulent-babyfood     0.030000   1.000     
1.000   

21000440 M    Beef, meat                         0.010000   1.000     
1.000   

21000441 M    Beef, meat-babyfood                0.010000   1.000     
1.000   

21000450 M    Beef, meat, dried                  0.010000   1.000     
1.920   

21000460 M    Beef, meat byproducts              0.020000   1.000     
1.000   

21000461 M    Beef, meat byproducts-babyfood     0.020000   1.000     
1.000   

21000470 M    Beef, fat                          0.010000   1.000     
1.000   

21000471 M    Beef,fat-babyfood                  0.010000   1.000     
1.000   

21000480 M    Beef, kidney                       0.010000   1.000     
1.000   

21000490 M    Beef, liver                        0.800000   1.000     
1.000   

21000491 M    Beef, liver-babyfood               0.800000   1.000     
1.000   

14000590 14   Brazil nut                         0.030000   1.000     
1.000   

15000650 15   Buckwheat                          0.030000   1.000     
1.000   

15000660 15   Buckwheat, flour                   0.030000   1.000     
1.000   

14000680 14   Butternut                          0.030000   1.000     
1.000   

14000810 14   Cashew                             0.030000   1.000     
1.000   

12000900 12   Cherry                             0.030000   1.000     
1.000   

12000901 12   Cherry-babyfood                    0.030000   1.000     
1.000   

12000910 12   Cherry, juice                      0.030000   1.000     
1.500   

12000911 12   Cherry, juice-babyfood             0.030000   1.000     
1.500   

14000920 14   Chestnut                           0.030000   1.000     
1.000   

06030980 6C   Chickpea, seed                     0.030000   1.000     
1.000   

06030981 6C   Chickpea, seed-babyfood            0.030000   1.000     
1.000   

06030990 6C   Chickpea, flour                    0.030000   1.000     
1.000   

10001060 10   Citrus citron                      0.030000   1.000     
1.000   

10001070 10   Citrus hybrids                     0.030000   1.000     
1.000   

10001080 10   Citrus, oil                        0.030000   1.000     
1.000   

15001200 15   Corn, field, flour                 0.030000   1.000     
1.000   

15001201 15   Corn, field, flour-babyfood        0.030000   1.000     
1.000   

15001210 15   Corn, field, meal                  0.030000   1.000     
1.000   

15001211 15   Corn, field, meal-babyfood         0.030000   1.000     
1.000   

15001220 15   Corn, field, bran                  0.030000   1.000     
1.000   

15001230 15   Corn, field, starch                0.030000   1.000     
1.000   

15001231 15   Corn, field, starch-babyfood       0.030000   1.000     
1.000   

15001240 15   Corn, field, syrup                 0.030000   1.000     
1.500   

15001241 15   Corn, field, syrup-babyfood        0.030000   1.000     
1.500   

15001250 15   Corn, field, oil                   0.030000   1.000     
1.000   

15001251 15   Corn, field, oil-babyfood          0.030000   1.000     
1.000   

15001260 15   Corn, pop                          0.030000   1.000     
1.000   

15001270 15   Corn, sweet                        0.030000   1.000     
1.000   

15001271 15   Corn, sweet-babyfood               0.030000   1.000     
1.000   

95001280 O    Cottonseed, oil                    0.030000   1.000     
1.000   

95001281 O    Cottonseed, oil-babyfood           0.030000   1.000     
1.000   

11001290 11   Crabapple                          0.030000   1.000     
1.000   

14001550 14   Filbert                            0.030000   1.000     
1.000   

14001560 14   Filbert, oil                       0.030000   1.000     
1.000   

23001690 M    Goat, meat                         0.010000   1.000     
1.000   

23001700 M    Goat, meat byproducts              0.020000   1.000     
1.000   

23001710 M    Goat, fat                          0.010000   1.000     
1.000   

23001720 M    Goat, kidney                       0.010000   1.000     
1.000   

23001730 M    Goat, liver                        0.800000   1.000     
1.000   

95001750 O    Grape                              0.030000   1.000     
1.000   

95001760 O    Grape, juice                       0.030000   1.000     
1.200   

95001761 O    Grape, juice-babyfood              0.030000   1.000     
1.200   

95001770 O    Grape, leaves                      0.030000   1.000     
1.000   

95001780 O    Grape, raisin                      0.030000   1.000     
4.300   

95001790 O    Grape, wine and sherry             0.030000   1.000     
1.000   

10001800 10   Grapefruit                         0.030000   1.000     
1.000   

10001810 10   Grapefruit, juice                  0.030000   1.000     
2.100   

06031820 6C   Guar, seed                         0.030000   1.000     
1.000   

06031821 6C   Guar, seed-babyfood                0.030000   1.000     
1.000   

14001850 14   Hickory nut                        0.030000   1.000     
1.000   

24001890 M    Horse, meat                        0.010000   1.000     
1.000   

10001970 10   Kumquat                            0.030000   1.000     
1.000   

10001990 10   Lemon                              0.030000   1.000     
1.000   

10002000 10   Lemon, juice                       0.030000   1.000     
2.000   

10002001 10   Lemon, juice-babyfood              0.030000   1.000     
2.000   

10002010 10   Lemon, peel                        0.030000   1.000     
1.000   

06032030 6C   Lentil, seed                       0.030000   1.000     
1.000   

10002060 10   Lime                               0.030000   1.000     
1.000   

10002070 10   Lime, juice                        0.030000   1.000     
2.000   

10002071 10   Lime, juice-babyfood               0.030000   1.000     
2.000   

11002100 11   Loquat                             0.030000   1.000     
1.000   

14002130 14   Macadamia nut                      0.030000   1.000     
1.000   

27002220 D    Milk, fat                          0.010000   1.000     
1.000   

27002221 D    Milk, fat - baby food/infant for   0.010000   1.000     
1.000   

27012230 D    Milk, nonfat solids                0.010000   1.000     
1.000   

27012231 D    Milk, nonfat solids-baby food/in   0.010000   1.000     
1.000   

27022240 D    Milk, water                        0.010000   1.000     
1.000   

27022241 D    Milk, water-babyfood/infant form   0.010000   1.000     
1.000   

27032251 D    Milk, sugar (lactose)-baby food/   0.010000   1.000     
1.000   

15002260 15   Millet, grain                      0.030000   1.000     
1.000   

12002300 12   Nectarine                          0.030000   1.000     
1.000   

15002310 15   Oat, bran                          0.030000   1.000     
1.000   

15002320 15   Oat, flour                         0.030000   1.000     
1.000   

15002321 15   Oat, flour-babyfood                0.030000   1.000     
1.000   

15002330 15   Oat, groats/rolled oats            0.030000   1.000     
1.000   

15002331 15   Oat, groats/rolled oats-babyfood   0.030000   1.000     
1.000   

10002400 10   Orange                             0.030000   1.000     
1.000   

10002410 10   Orange, juice                      0.030000   1.000     
1.800   

10002411 10   Orange, juice-babyfood             0.030000   1.000     
1.800   

10002420 10   Orange, peel                       0.030000   1.000     
1.000   

06022550 6B   Pea, succulent                     0.030000   1.000     
1.000   

06022551 6B   Pea, succulent-babyfood            0.030000   1.000     
1.000   

06032560 6C   Pea, dry                           0.030000   1.000     
1.000   

06032561 6C   Pea, dry-babyfood                  0.030000   1.000     
1.000   

06012570 6A   Pea, edible podded, succulent      0.030000   1.000     
1.000   

06032580 6C   Pea, pigeon, seed                  0.030000   1.000     
1.000   

06022590 6B   Pea, pigeon, succulent             0.030000   1.000     
1.000   

12002600 12   Peach                              0.030000   1.000     
1.000   

12002601 12   Peach-babyfood                     0.030000   1.000     
1.000   

12002610 12   Peach, dried                       0.030000   1.000     
7.000   

12002611 12   Peach, dried-babyfood              0.030000   1.000     
7.000   

12002620 12   Peach, juice                       0.030000   1.000     
1.500   

12002621 12   Peach, juice-babyfood              0.030000   1.000     
1.500   

11002660 11   Pear                               0.030000   1.000     
1.000   

11002661 11   Pear-babyfood                      0.030000   1.000     
1.000   

11002670 11   Pear, dried                        0.030000   1.000     
6.250   

11002680 11   Pear, juice                        0.030000   1.000     
1.000   

11002681 11   Pear, juice-babyfood               0.030000   1.000     
1.000   

14002690 14   Pecan                              0.030000   1.000     
1.000   

14002820 14   Pistachio                          0.030000   1.000     
1.000   

12002850 12   Plum                               0.030000   1.000     
1.000   

12002851 12   Plum-babyfood                      0.030000   1.000     
1.000   

12002860 12   Plum, prune, fresh                 0.030000   1.000     
1.000   

12002861 12   Plum, prune, fresh-babyfood        0.030000   1.000     
1.000   

12002870 12   Plum, prune, dried                 0.030000   1.000     
5.000   

12002871 12   Plum, prune, dried-babyfood        0.030000   1.000     
5.000   

12002880 12   Plum, prune, juice                 0.030000   1.000     
1.400   

12002881 12   Plum, prune, juice-babyfood        0.030000   1.000     
1.400   

25002900 M    Pork, meat                         0.010000   1.000     
1.000   

25002901 M    Pork, meat-babyfood                0.010000   1.000     
1.000   

25002910 M    Pork, skin                         0.010000   1.000     
1.000   

25002920 M    Pork, meat byproducts              0.020000   1.000     
1.000   

25002921 M    Pork, meat byproducts-babyfood     0.020000   1.000     
1.000   

25002930 M    Pork, fat                          0.010000   1.000     
1.000   

25002931 M    Pork, fat-babyfood                 0.010000   1.000     
1.000   

25002940 M    Pork, kidney                       0.010000   1.000     
1.000   

25002950 M    Pork, liver                        0.800000   1.000     
1.000   

10003070 10   Pummelo                            0.030000   1.000     
1.000   

11003100 11   Quince                             0.030000   1.000     
1.000   

29003120 M    Rabbit, meat                       0.010000   1.000     
1.000   

15003230 15   Rice, white                        0.030000   1.000     
1.000   

15003231 15   Rice, white-babyfood               0.030000   1.000     
1.000   

15003240 15   Rice, brown                        0.030000   1.000     
1.000   

15003241 15   Rice, brown-babyfood               0.030000   1.000     
1.000   

15003250 15   Rice, flour                        0.030000   1.000     
1.000   

15003251 15   Rice, flour-babyfood               0.030000   1.000     
1.000   

15003260 15   Rice, bran                         0.030000   1.000     
1.000   

15003261 15   Rice, bran-babyfood                0.030000   1.000     
1.000   

15003280 15   Rye, grain                         0.030000   1.000     
1.000   

15003290 15   Rye, flour                         0.030000   1.000     
1.000   

26003390 M    Sheep, meat                        0.010000   1.000     
1.000   

26003391 M    Sheep, meat-babyfood               0.010000   1.000     
1.000   

26003400 M    Sheep, meat byproducts             0.010000   1.000     
1.000   

26003410 M    Sheep, fat                         0.010000   1.000     
1.000   

26003411 M    Sheep, fat-babyfood                0.010000   1.000     
1.000   

26003420 M    Sheep, kidney                      0.010000   1.000     
1.000   

26003430 M    Sheep, liver                       0.010000   1.000     
1.000   

15003440 15   Sorghum, grain                     0.030000   1.000     
1.000   

15003450 15   Sorghum, syrup                     0.030000   1.000     
1.000   

06003470 6    Soybean, seed                      0.030000   1.000     
1.000   

06003480 6    Soybean, flour                     0.030000   1.000     
1.000   

06003481 6    Soybean, flour-babyfood            0.030000   1.000     
1.000   

06003490 6    Soybean, soy milk                  0.030000   1.000     
1.000   

06003491 6    Soybean, soy milk-babyfood or in   0.030000   1.000     
1.000   

06003500 6    Soybean, oil                       0.030000   1.000     
1.000   

06003501 6    Soybean, oil-babyfood              0.030000   1.000     
1.000   

20003640 20   Sunflower, seed                    1.000000   1.000     
1.000   

20003650 20   Sunflower, oil                     1.000000   1.000     
1.000   

20003651 20   Sunflower, oil-babyfood            1.000000   1.000     
1.000   

10003690 10   Tangerine                          0.030000   1.000     
1.000   

10003700 10   Tangerine, juice                   0.030000   1.000     
1.000   

15003810 15   Triticale, flour                   0.030000   1.000     
1.000   

15003811 15   Triticale, flour-babyfood          0.030000   1.000     
1.000   

14003910 14   Walnut                             0.030000   1.000     
1.000   

86010000 O    Water, direct, all sources         0.173000   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.173000   1.000     
1.000   

15004010 15   Wheat, grain                       0.030000   1.000     
1.000   

15004011 15   Wheat, grain-babyfood              0.030000   1.000     
1.000   

15004020 15   Wheat, flour                       0.030000   1.000     
1.000   

15004021 15   Wheat, flour-babyfood              0.030000   1.000     
1.000   

15004030 15   Wheat, germ                        0.030000   1.000     
1.000   

15004040 15   Wheat, bran                        0.030000   1.000     
1.000   

15004050 15   Wild rice                          0.030000   1.000     
1.000   

Chronic Results File.

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for SAFLUFENACIL                     (1994-98
data)

Residue file name: C:\Documents and Settings\gkramer\My
Documents\GK\%Saflufenacil\Saflufenacil_Chronic.R98

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#2 used.

Analysis Date 04-16-2009/13:39:38     Residue file dated:
04-14-2009/13:21:45/8

Reference dose (RfD, Chronic) = .046 mg/kg bw/day

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.004043                
8.8%

U.S. Population (spring season)             0.004010                
8.7%

U.S. Population (summer season)             0.004310                
9.4%

U.S. Population (autumn season)             0.003924                
8.5%

U.S. Population (winter season)             0.003925                
8.5%

Northeast region                            0.003754                
8.2%

Midwest region                              0.004086                
8.9%

Southern region                             0.003832                
8.3%

Western region                              0.004594               
10.0%

Hispanics                                   0.004601               
10.0%

Non-hispanic whites                         0.003939                
8.6%

Non-hispanic blacks                         0.003872                
8.4%

Non-hisp/non-white/non-black                0.004929               
10.7%

All infants (< 1 year)                      0.012951               
28.2%

Nursing infants                             0.004831               
10.5%

Non-nursing infants                         0.016032               
34.9%

Children 1-6  yrs                           0.006287               
13.7%

Children 7-12 yrs                           0.003916                
8.5%

Females 13-19 (not preg or nursing)         0.002897                
6.3%

Females 20+ (not preg or nursing)           0.003884                
8.4%

Females 13-50 yrs                           0.003827                
8.3%

Females 13+ (preg/not nursing)              0.003875                
8.4%

Females 13+ (nursing)                       0.005414               
11.8%

Males 13-19 yrs                             0.003081                
6.7%

Males 20+ yrs                               0.003535                
7.7%

Seniors 55+                                 0.003818                
8.3%

Children 1-2 yrs                            0.006895               
15.0%

Children 3-5 yrs                            0.006176               
13.4%

Children 6-12 yrs                           0.004141                
9.0%

Youth 13-19 yrs                             0.003002                
6.5%

Adults 20-49 yrs                            0.003672                
8.0%

Adults 50+ yrs                              0.003821                
8.3%

Females 13-49 yrs                           0.003659                
8.0%

Saflufenacil		        Dietary Exposure and Risk Assessment			    DP
Number:  364183

________________________________________________________________________
______________

Page   PAGE  4  of   NUMPAGES  18