Document ID: EPA-HQ-OPP-2008-0945-0007
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2009-12-09T05:00Z

SEQ CHAPTER \h \r 1 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460      

	OFFICE OF PREVENTION, PESTICIDES

                                                                        
                   AND TOXIC SUBSTANCES

	

MEMORANDUM

Date:  		11 August 2009  

SUBJECT:	Clothianidin Acute and Chronic Aggregate Dietary (Food and
Drinking Water) Exposure and Risk Assessments

PC Code:  044309	DP Barcode:   D364363, D364364, D366467

Decision No.: 397135	Registration No.: 

Petition Nos.: 8F7395, 8E7460, 9F7530, 8F7416, 8F7413, 8E7411
(thiamethoxam)	Regulatory Action:  Section 3

Risk Assessment Type: Single Chemical, Aggregate	Case No.:  N/A

TXR No.: N/A	CAS No.:  210880-92-5

MRID No.: None	40 CFR:180.586

FROM:	Michael A. Doherty, Ph.D., Chemist

Risk Assessment Branch II

Health Effects Division (7509P)

THROUGH:	David Hrdy, Senior Biologist

Debra Rate, Ph.D., Biologist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P)

		Richard A. Loranger, Ph.D., Senior Scientist 

Risk Assessment Branch II

Health Effects Division (7509P)

TO:		Michael A. Doherty, Ph.D., Chemist

Risk Assessment Branch II

Health Effects Division (7509P)

Dennis McNeilly, Chemist

Risk Assessment Branch II

Health Effects Division (7509P)

Kable (Bo) Davis/Venus Eagle (Team 01)

Insecticide/Rodenticide Branch

Registration Division (7505P)

Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure
and risk assessments were conducted using the Dietary Exposure
Evaluation Model DEEM-FCID™, Version 2.03 which use food consumption
data from the U.S. Department of Agriculture’s Continuing Surveys of
Food Intakes by Individuals (CSFII) from 1994-1996 and 1998.  The
analyses were performed to support Section 3 registration requests for
clothianidin and thiamethoxam.

Both the acute and chronic assessments are based on tolerance-level
residues, assume 100% crop treated, and include estimates for residues
of clothianidin in drinking water.  Clothianidin is a major metabolite
of thiamethoxam, and these analyses include thiamethoxam as a source of
clothianidin exposure.  These assessments address requests for new uses
of clothianidin as foliar treatments on berries (Subgroup 13-07H),
Brassica vegetables (Group 5), cotton, cucurbit vegetables (Group 9),
figs, fruiting vegetables (Group 8), leafy vegetables (Group 4),
peaches, pomegranates, soybeans, tuberous and corm vegetables (Subgroup
1C), tree nuts (Group 14); as seed treatments on root and tuber
vegetables (Group 1), bulb vegetables (Group 3), leafy greens (Subgroup
4A), Brassica leafy vegetables (Subgroup 5B), fruiting vegetables (Group
8), cucurbit vegetables (Group 9), and cereal grains (except rice; Group
15); and new uses of thiamethoxam on rice, sugar beets, and tropical
fruits. 

   

Based on highly conservative, health-protective assumptions, the
aggregate dietary risk estimates are below HED’s level of concern
(100% of the population-adjusted dose, PAD) for all durations and
population subgroups.  For the acute assessment, the maximum estimated
risk is for 23% of the acute PAD (aPAD).  Similarly, the maximum
estimated risk for the chronic assessment is for children 1-2 years of
age at 19% of the chronic PAD (cPAD).  Clothianidin is not a human
carcinogen; therefore, cancer risk is not an issue for this chemical.

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL,
e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  HED is generally
concerned when estimated cancer risk exceeds one in one million.
References which discuss the acute and chronic risk assessments in more
detail are available on the EPA/pesticides web site:  “Available
Information on Assessing Exposure from Pesticides, A User’s Guide,”
21-JUN-2000, web link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see
SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for clothianidin was conducted
by M. Doherty (12 August 2008, D354328) in support of new registrations
for thiamethoxam.  Note that since that assessment, OPP has removed the
database uncertainty factor for clothianidin and, as a result, the PADs
have increased by a factor of 10.

II.	Residue Information

Residue chemistry information to support the requested uses of
clothianidin and thiamethoxam can be found in the summary documents with
the following DP Numbers:  D355896, D360842, D362499, D357454, D357455,
D357449, and D357450.

The acute and chronic assessments rely on tolerance-level residues for
all crops with registered and/or requested clothianidin uses.  For crops
except leafy vegetables, the residue of concern for risk assessment
purposes is the parent compound.  For root crops and leafy vegetables,
the residues of concern are the parent compound and the TMG metabolite. 
Field trial data show no detectable residues of TMG in root crops and
that TMG does not exceed 10% of the parent compound residue level in
leafy vegetables.  A factor of 1.1 (entered into the model as Adjustment
Factor 1) has been incorporated into the assessment for leafy vegetables
to account for the presence of TMG.  For livestock commodities, the
residues of concern are the parent compound as well as the metabolites
TZU, TZG, TZNG, ATMG-pyruvate, and ATG-acetate.  Milk is currently the
only livestock-derived commodity with a tolerance for clothianidin.  A
factor of 1.5, which is based on metabolism data, has been incorporated
into the assessment to account for the residues of concern in milk.

There are a number of crops for which uses of both clothianidin and
thiamethoxam have been registered.  The labels for the various end-use
products containing these active ingredients prohibit the application of
both active ingredients to the same crop during a growing cycle.  Due to
that restriction and the assumption of 100% crop treated, a single value
reflecting the greatest clothianidin residue from either active
ingredient has been used for crops listed for use with both active
ingredients (versus combined estimates from clothianidin and from
thiamethoxam).  Generally, this assessment uses the established or
recommended clothianidin tolerance for crops having tolerances for both
compounds (Subgroup 13G, based on observed clothianidin residues in
thiamethoxam strawberry field trials, being the exception).  For foods
with thiamethoxam tolerances but without clothianidin tolerances,
maximum residues of clothianidin observed in thiamethoxam field trials
have been used in these assessments.  These include meats, meat
by-products, artichoke, tropical fruits, coffee, hop, mint, rice, and
strawberry.  It is HED’s understanding that registration of
clothianidin on the stone fruit group will be pursued in the near
future.  Evaluation of residue data by PMRA (Health Canada) shows that a
stone fruit group tolerance would be set based on residues in/on
peaches.  HED has included the entire stone fruit group in these
analyses, using the recommended tolerance level of 0.8 ppm for peach.

Empirical processing factors have been included in these analyses. 
Complete listings of the residue estimates, metabolite factors, and
processing factors used in these analyses may be found in Attachments 1
and 2.

 Drinking Water Data

ining Multiple Active Ingredients, Sepresto 75WS and PROCEED™ Optimum,
and New Uses for Arena 50WDG, V-10170 2.13SC, V-1017 5FS, CLUTCH 50WDG
and Belay 16WSG” (J. Meléndez, D360266, 4 August 2009) and
incorporated directly into this dietary assessment.  Water residues were
incorporated in the DEEM-FCID into the food categories “water, direct,
all sources” and “water, indirect, all sources.”   Previously
derived residue estimates for drinking water based on turf uses
(D313414, D313415; Michael Barrett; 23
Au畧瑳㈠〰⤵愠敲朠敲瑡牥琠慨⁮桴獯⁥敲畳瑬湩⁧牦
浯愠祮漠⁦桴⁥敮汷⁹敲畱獥整⁤獵獥‮吠敨敲潦敲‬
桴⁥慶畬獥甠敳⁤湩琠敨瀠敲楶畯⁳楤瑥牡⁹獡敳獳敭
瑮⠠⸰〰㈷‹灰⁭潦⁲捡瑵⁥湡污獹獥愠摮〠〮㔰㠸映
牯挠牨湯捩愠慮祬敳⥳爠浥楡⁮潷獲⵴慣敳攠瑳浩瑡獥
മ

IV.	DEEM-FCID™ Program and Consumption Information

Clothianidin acute and chronic dietary exposure assessments were
conducted using the Dietary Exposure Evaluation Model software with the
Food Commodity Intake Database DEEM-FCID™, Version 2.03 which
incorporates consumption data from USDA’s Continuing Surveys of Food
Intakes by Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98
data are based on the reported consumption of more than 20,000
individuals over two non-consecutive survey days.  Foods “as
consumed” (e.g., apple pie) are linked to EPA-defined food commodities
(e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicly available recipe
translation files developed jointly by USDA/ARS and EPA.  For chronic
exposure assessment, consumption data are averaged for the entire U.S.
population and within population subgroups, but for acute exposure
assessment are retained as individual consumption events.  Based on
analysis of the 1994-96, 98 CSFII consumption data, which took into
account dietary patterns and survey respondents, HED concluded that it
is most appropriate to report risk for the following population
subgroups: the general U.S. population, all infants (<1 year old),
children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49,
females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., only those who reported
eating relevant commodities/food forms) and a per-capita (i.e., those
who reported eating the relevant commodities as well as those who did
not) basis.  In accordance with HED policy, per capita exposure and risk
are reported for all tiers of analysis.  However, for Tiers 1 and 2, any
significant differences in user vs. per capita exposure and risk are
specifically identified and noted in the risk assessment.

V.	Toxicological Information

The clothianidin risk assessment team has re-examined the doses and
endpoints which were previously selected for dietary assessment.  At the
time of the last assessment, OPP had put a 10X database uncertainty
factor in place for lack of a developmental immunotoxicity study.  That
study has since been submitted to OPP, reviewed, found to be acceptable,
and has not resulted in the selection of new endpoints or points of
departure.  The 10X factor has, therefore, been removed.  The revised
PADs are summarized in Table 1.

Table 1.  Clothianidin Toxicological Doses and Endpoints for Use in
Human Health Dietary Risk Assessments

Exposure/

Scenario	Point of Departure	Uncertainty/FQPA Safety Factors	Level of
Concern for Risk Assessment	Study and Toxicological Effects

Acute Dietary

Females age 

13-49 	NOAEL =  

25 mg/kg/day	UFA = 10x

UFH = 10x

SFFQPA =1

 	aRfD =

0.25 mg/kg/day

aPAD =

0.25 mg/kg/day	Rabbit developmental  study 

LOAEL = 75 mg/kg/day based on increased litter incidence of a missing
lobe of the lung

Acute Dietary

General population	NOAEL = 

25

mg/kg/day	UFA = 10x

UFH = 10x

SFFQPA  = 1	aRfD =

0.25 mg/kg/day

aPAD =

0.25 mg/kg/day	Special neurotoxicity/pharmacol

study in mice 

LOAEL = 50 mg/kg/day based on transient signs of decreased spontaneous
motor activity, tremors and deep respirations

Chronic Dietary

All populations including infants and children	NOAEL= 

9.8 mg/kg/day  	UFA = 10x

UFH = 10x

SFFQPA =1	cRfD=0.098 mg/kg/day

cPAD=0.098 mg/kg/day	2-Generation reproduction study 

LOAEL = 31.2 mg/kg/day based on decreased body weight gains and delayed
sexual maturation, decreased absolute thymus weights in F1 pups and
increased stillbirths in both generations

Cancer (oral, dermal, inhalation)	“Not Likely to be Carcinogenic to
Humans” 

Point of Departure (POD) = A data point or an estimated point that is
derived from observed dose-response data and  used to mark the beginning
of extrapolation to determine risk associated with lower environmentally
relevant human exposures.  NOAEL = no observed adverse effect level. 
LOAEL = lowest observed adverse effect level.  UF = uncertainty factor. 
UFA = extrapolation from animal to human (interspecies).  UFH =
potential variation in sensitivity among members of the human population
(intraspecies).  UFL = use of a LOAEL to extrapolate a NOAEL.  UFS = use
of a short-term study for long-term risk assessment.  UFDB = to account
for the absence of key date (i.e., lack of a critical study).  FQPA SF =
FQPA Safety Factor.  PAD = population adjusted dose (a = acute, c =
chronic).  RfD = reference dose.  MOE = margin of exposure.  LOC = level
of concern.  N/A = not applicable.

VI.	Results/Discussion 

The results of the screening-level dietary exposure assessments are
summarized in Table 2.  For both the acute and chronic analyses, the
greatest exposure estimate is for the population subgroup Children 1-2
years old.  Risk estimates for this subgroup are 23% aPAD and 19% cPAD. 
These estimates are well below HED’s level of concern (typically 100%
of the PAD).  There are no dietary exposure considerations associated
with clothianidin that would preclude establishing tolerances for
clothianidin or thiamethoxam based on the requested uses.  More complete
listings of the acute and chronic exposure/risk estimates are available
in Attachments 3 and 4.

Table 2.  Summary of Dietary Exposure and Risk Estimates for
Clothianidin.

Population Subgroup	Acute (95th Pecentile of Exposure)	Chronic

	Exposure, mg/day	Risk, % aPAD	Exposure, mg/day	Risk, % cPAD

U.S. Population (total)	0.015019	6	0.004582	5

All infants (< 1 year)	0.048266	19	0.012680	13

Children 1-2 yrs	0.057317	23	0.018429	19

Children 3-5 yrs	0.039089	16	0.012188	12

Children 6-12 yrs	0.018014	7	0.005801	6

Youth 13-19 yrs	0.011055	4	0.003194	3

Adults 20-49 yrs	0.010157	4	0.003229	3

Adults 50+ yrs	0.010121	4	0.003438	4

Females 13-49 yrs	0.010797	4	0.003325	3

The population subgroup(s) with the highest exposure/risk estimates are
shown in bold.

VII.	Characterization of Inputs/Outputs

The acute and chronic assessments are based on highly conservative,
health-protective assumptions regarding residue levels and percentage of
crops treated.  The analyses resulting from these assumptions should be
considered screening-level analyses that likely overestimate actual
dietary exposure to clothianidin.

VIII.	Conclusions

Expansion of the uses of clothianidin and thiamethoxam, as requested,
will not result in dietary exposure to clothianidin that exceeds HED’s
level of concern.  There are no dietary exposure considerations
associated with clothianidin that would preclude registering the
requested uses of these compounds or establishing tolerances for
residues of clothianidin in/on the requested commodities.  An aggregate
risk assessment that takes into account potential exposure from
residential as well as dietary sources is forthcoming.

IX.	List of Attachments

1.  Inputs for the Acute Dietary Exposure Assessment of Clothianidin.

2.  Inputs for the Chronic Dietary Exposure Assessment of Clothianidin.

3.  Summary of the Results of the Acute Dietary Exposure Assessment of
Clothianidin.

4.  Summary of the Results of the Chronic Dietary Exposure Assessment of
Clothianidin.

Attachment 1.  Inputs for the Acute Dietary Exposure Assessment of
Clothianidin.

U.S. Environmental Protection Agency                                
Ver. 2.02

DEEM-FCID Acute analysis for CLOTHIANIDIN

Residue file name: C:\Documents and Settings\mdoherty\My
Documents\Chemistry Reviews\!DEEM Runs\Clothianidin and
Thiamethoxam\2009\044309 (2009) Acute.R98

Analysis Date 07-29-2009             Residue file dated:
07-29-2009/13:08:25/8

Reference dose (aRfD) = 0.25 mg/kg bw/day

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Food Name                         (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

14000030 14   Almond                             0.010000   1.000  1.000

14000031 14   Almond-babyfood                    0.010000   1.000  1.000

14000040 14   Almond, oil                        0.010000   1.000  1.000

14000041 14   Almond, oil-babyfood               0.010000   1.000  1.000

04010050 4A   Amaranth, leafy                    3.000000   1.100  1.000
  1.1 factor to account for TMG metabolite

11000070 11   Apple, fruit with peel             1.000000   1.000  1.000

11000080 11   Apple, peeled fruit                1.000000   1.000  1.000

11000081 11   Apple, peeled fruit-babyfood       1.000000   1.000  1.000

11000090 11   Apple, dried                       1.000000   8.000  1.000

11000091 11   Apple, dried-babyfood              1.000000   8.000  1.000

11000100 11   Apple, juice                       1.000000   1.300  1.000

11000101 11   Apple, juice-babyfood              1.000000   1.300  1.000

11000110 11   Apple, sauce                       1.000000   1.000  1.000

11000111 11   Apple, sauce-babyfood              1.000000   1.000  1.000

12000120 12   Apricot                            0.800000   1.000  1.000

12000121 12   Apricot-babyfood                   0.800000   1.000  1.000

12000130 12   Apricot, dried                     0.800000   6.000  1.000

12000140 12   Apricot, juice                     0.800000   1.000  1.000

12000141 12   Apricot, juice-babyfood            0.800000   1.000  1.000

01030150 1CD  Arrowroot, flour                   0.300000   1.000  1.000

01030151 1CD  Arrowroot, flour-babyfood          0.300000   1.000  1.000

95000160 O    Artichoke, globe                   0.029000   1.000  1.000
  From thiamethoxam

01030170 1CD  Artichoke, Jerusalem               0.300000   1.000  1.000

04010180 4A   Arugula                            3.000000   1.100  1.000
  1.1 factor to account for TMG metabolite

95000200 O    Avocado                            0.020000   1.000  1.000
  From thiamethoxam

09020210 9B   Balsam pear                        0.060000   1.000  1.000

15000250 15   Barley, pearled barley             0.020000   1.000  1.000

15000251 15   Barley, pearled barley-babyfood    0.020000   1.000  1.000

15000260 15   Barley, flour                      0.020000   1.000  1.000

15000261 15   Barley, flour-babyfood             0.020000   1.000  1.000

15000270 15   Barley, bran                       0.020000   1.000  1.000

06030300 6C   Bean, black, seed                  0.010000   1.000  1.000

06020310 6B   Bean, broad, succulent             0.010000   1.000  1.000

06030320 6C   Bean, broad, seed                  0.010000   1.000  1.000

06020330 6B   Bean, cowpea, succulent            0.010000   1.000  1.000

06030340 6C   Bean, cowpea, seed                 0.010000   1.000  1.000

06030350 6C   Bean,  great northern, seed        0.010000   1.000  1.000

06030360 6C   Bean, kidney, seed                 0.010000   1.000  1.000

06020370 6B   Bean, lima, succulent              0.010000   1.000  1.000

06030380 6C   Bean, lima, seed                   0.010000   1.000  1.000

06030390 6C   Bean, mung, seed                   0.010000   1.000  1.000

06030400 6C   Bean, navy, seed                   0.010000   1.000  1.000

06030410 6C   Bean, pink, seed                   0.010000   1.000  1.000

06030420 6C   Bean, pinto, seed                  0.010000   1.000  1.000

06010430 6A   Bean, snap, succulent              0.010000   1.000  1.000

06010431 6A   Bean, snap, succulent-babyfood     0.010000   1.000  1.000

21000440 M    Beef, meat                         0.010000   1.000  1.000
  From thiamethoxam

21000441 M    Beef, meat-babyfood                0.010000   1.000  1.000
  From thiamethoxam

21000450 M    Beef, meat, dried                  0.010000   1.920  1.000
  From thiamethoxam

21000460 M    Beef, meat byproducts              0.010000   1.000  1.000
  From thiamethoxam

21000461 M    Beef, meat byproducts-babyfood     0.010000   1.000  1.000
  From thiamethoxam

21000480 M    Beef, kidney                       0.010000   1.000  1.000
  From thiamethoxam

21000490 M    Beef, liver                        0.010000   1.000  1.000
  From thiamethoxam

21000491 M    Beef, liver-babyfood               0.010000   1.000  1.000
  From thiamethoxam

01010500 1AB  Beet, garden, roots                0.200000   1.000  1.000

01010501 1AB  Beet, garden, roots-babyfood       0.200000   1.000  1.000

02000510 2    Beet, garden, tops                 0.600000   1.000  1.000

01010520 1A   Beet, sugar                        0.020000   1.000  1.000

01010521 1A   Beet, sugar-babyfood               0.020000   1.000  1.000

01010530 1A   Beet, sugar, molasses              0.020000   2.900  1.000

01010531 1A   Beet, sugar, molasses-babyfood     0.020000   2.900  1.000

13010550 13A  Blackberry                         0.040000   1.000  1.000

13010560 13A  Blackberry, juice                  0.040000   1.000  1.000

13010561 13A  Blackberry, juice-babyfood         0.040000   1.000  1.000

13020570 13B  Blueberry                          0.050000   1.000  1.000

13020571 13B  Blueberry-babyfood                 0.050000   1.000  1.000

13010580 13A  Boysenberry                        0.040000   1.000  1.000

14000590 14   Brazil nut                         0.010000   1.000  1.000

05010610 5A   Broccoli                           1.900000   1.000  1.000

05010611 5A   Broccoli-babyfood                  1.900000   1.000  1.000

05010620 5A   Broccoli, Chinese                  1.900000   1.000  1.000

05020630 5B   Broccoli raab                      1.900000   1.000  1.000

05010640 5A   Brussels sprouts                   1.900000   1.000  1.000

01010670 1AB  Burdock                            0.200000   1.000  1.000

14000680 14   Butternut                          0.010000   1.000  1.000

05010690 5A   Cabbage                            1.900000   1.000  1.000

05020700 5B   Cabbage, Chinese, bok choy         1.900000   1.000  1.000

05010710 5A   Cabbage, Chinese, napa             1.900000   1.000  1.000

05010720 5A   Cabbage, Chinese, mustard          1.900000   1.000  1.000

09010750 9A   Cantaloupe                         0.060000   1.000  1.000

04020760 4B   Cardoon                            0.400000   1.000  1.000
  From Thiamethoxam

01010780 1AB  Carrot                             0.200000   1.000  1.000

01010781 1AB  Carrot-babyfood                    0.200000   1.000  1.000

01010790 1AB  Carrot, juice                      0.200000   1.000  1.000

09010800 9A   Casaba                             0.060000   1.000  1.000

14000810 14   Cashew                             0.010000   1.000  1.000

01030820 1CD  Cassava                            0.300000   1.000  1.000

01030821 1CD  Cassava-babyfood                   0.300000   1.000  1.000

05010830 5A   Cauliflower                        1.900000   1.000  1.000

01010840 1AB  Celeriac                           0.200000   1.000  1.000

04020850 4B   Celery                             0.400000   1.000  1.000
  From Thiamethoxam

04020851 4B   Celery-babyfood                    0.400000   1.000  1.000
  From Thiamethoxam

04020860 4B   Celery, juice                      0.400000   1.000  1.000
  From Thiamethoxam

04020870 4B   Celtuce                            0.400000   1.000  1.000
  From Thiamethoxam

09020880 9B   Chayote, fruit                     0.060000   1.000  1.000

12000900 12   Cherry                             0.800000   1.000  1.000

12000901 12   Cherry-babyfood                    0.800000   1.000  1.000

12000910 12   Cherry, juice                      0.800000   1.500  1.000

12000911 12   Cherry, juice-babyfood             0.800000   1.500  1.000

14000920 14   Chestnut                           0.010000   1.000  1.000

06030980 6C   Chickpea, seed                     0.010000   1.000  1.000

06030981 6C   Chickpea, seed-babyfood            0.010000   1.000  1.000

06030990 6C   Chickpea, flour                    0.010000   1.000  1.000

01011000 1AB  Chicory, roots                     0.200000   1.000  1.000

02001010 2    Chicory, tops                      0.600000   1.000  1.000

09021020 9B   Chinese waxgourd                   0.060000   1.000  1.000

04011040 4A   Chrysanthemum, garland             3.000000   1.100  1.000
  1.1 factor to account for TMG metabolite

10001060 10   Citrus citron                      0.010000   1.000  1.000

10001070 10   Citrus hybrids                     0.010000   1.000  1.000

10001080 10   Citrus, oil                        0.010000   1.000  1.000

95001150 O    Coffee, roasted bean               0.010000   1.000  1.000
  From thiamethoxam

95001160 O    Coffee, instant                    0.010000   1.000  1.000
  From thiamethoxam

05021170 5B   Collards                           1.900000   1.000  1.000

15001200 15   Corn, field, flour                 0.010000   1.000  1.000

15001201 15   Corn, field, flour-babyfood        0.010000   1.000  1.000

15001210 15   Corn, field, meal                  0.010000   1.000  1.000

15001211 15   Corn, field, meal-babyfood         0.010000   1.000  1.000

15001220 15   Corn, field, bran                  0.010000   1.000  1.000

15001230 15   Corn, field, starch                0.010000   1.000  1.000

15001231 15   Corn, field, starch-babyfood       0.010000   1.000  1.000

15001240 15   Corn, field, syrup                 0.010000   1.000  1.000

15001241 15   Corn, field, syrup-babyfood        0.010000   1.000  1.000

15001250 15   Corn, field, oil                   0.010000   1.000  1.000

15001251 15   Corn, field, oil-babyfood          0.010000   1.000  1.000

15001260 15   Corn, pop                          0.010000   1.000  1.000

15001270 15   Corn, sweet                        0.010000   1.000  1.000

15001271 15   Corn, sweet-babyfood               0.010000   1.000  1.000

95001280 O    Cottonseed, oil                    0.200000   1.000  1.000

95001281 O    Cottonseed, oil-babyfood           0.200000   1.000  1.000

11001290 11   Crabapple                          1.000000   1.000  1.000

95001300 O    Cranberry                          0.010000   1.000  1.000

95001301 O    Cranberry-babyfood                 0.010000   1.000  1.000

95001310 O    Cranberry, dried                   0.010000   1.000  1.000

95001320 O    Cranberry, juice                   0.010000   1.100  1.000

95001321 O    Cranberry, juice-babyfood          0.010000   1.100  1.000

04011330 4A   Cress, garden                      3.000000   1.100  1.000
  1.1 factor to account for TMG metabolite

04011340 4A   Cress, upland                      3.000000   1.100  1.000
  1.1 factor to account for TMG metabolite

09021350 9B   Cucumber                           0.060000   1.000  1.000

13021360 13B  Currant                            0.050000   1.000  1.000

13021370 13B  Currant, dried                     0.050000   1.000  1.000

04011380 4A   Dandelion, leaves                  3.000000   1.100  1.000
  1.1 factor to account for TMG metabolite

01031390 1CD  Dasheen, corm                      0.300000   1.000  1.000

02001400 2    Dasheen, leaves                    0.600000   1.000  1.000

13011420 13A  Dewberry                           0.040000   1.000  1.000

08001480 8    Eggplant                           0.200000   1.000  1.000

13021490 13B  Elderberry                         0.050000   1.000  1.000

04011500 4A   Endive                             3.000000   1.100  1.000
  1.1 factor to account for TMG metabolite

04021520 4B   Fennel, Florence                   0.400000   1.000  1.000
  From Thiamethoxam

95001530 O    Fig                                0.050000   1.000  1.000

95001540 O    Fig, dried                         0.050000   1.000  1.000

14001550 14   Filbert                            0.010000   1.000  1.000

14001560 14   Filbert, oil                       0.010000   1.000  1.000

20001630 20   Flaxseed, oil                      0.010000   1.000  1.000

03001640 3    Garlic                             0.450000   1.000  1.000

03001650 3    Garlic, dried                      0.450000   1.000  1.000

03001651 3    Garlic, dried-babyfood             0.450000   1.000  1.000

01031660 1CD  Ginger                             0.300000   1.000  1.000

01031661 1CD  Ginger-babyfood                    0.300000   1.000  1.000

01031670 1CD  Ginger, dried                      0.300000   1.000  1.000

01011680 1AB  Ginseng, dried                     0.200000   1.000  1.000

23001690 M    Goat, meat                         0.010000   1.000  1.000
  From thiamethoxam

23001700 M    Goat, meat byproducts              0.010000   1.000  1.000
  From thiamethoxam

23001720 M    Goat, kidney                       0.010000   1.000  1.000
  From thiamethoxam

23001730 M    Goat, liver                        0.010000   1.000  1.000
  From thiamethoxam

13021740 13B  Gooseberry                         0.050000   1.000  1.000

95001750 O    Grape                              0.600000   1.000  1.000

95001760 O    Grape, juice                       0.600000   1.200  1.000

95001761 O    Grape, juice-babyfood              0.600000   1.200  1.000

95001770 O    Grape, leaves                      0.600000   1.000  1.000

95001780 O    Grape, raisin                      0.600000   2.500  1.000

95001790 O    Grape, wine and sherry             0.600000   1.200  1.000

10001800 10   Grapefruit                         0.010000   1.000  1.000

10001810 10   Grapefruit, juice                  0.010000   1.000  1.000

06031820 6C   Guar, seed                         0.010000   1.000  1.000

06031821 6C   Guar, seed-babyfood                0.010000   1.000  1.000

14001850 14   Hickory nut                        0.010000   1.000  1.000

09011870 9A   Honeydew melon                     0.060000   1.000  1.000

95001880 O    Hop                                0.028000   1.000  1.000
  From thiamethoxam

24001890 M    Horse, meat                        0.010000   1.000  1.000
  From thiamethoxam

01011900 1AB  Horseradish                        0.200000   1.000  1.000

13021910 13B  Huckleberry                        0.050000   1.000  1.000

05021940 5B   Kale                               1.900000   1.000  1.000

05011960 5A   Kohlrabi                           1.900000   1.000  1.000

10001970 10   Kumquat                            0.010000   1.000  1.000

03001980 3    Leek                               0.450000   1.000  1.000

10001990 10   Lemon                              0.010000   1.000  1.000

10002000 10   Lemon, juice                       0.010000   1.000  1.000

10002001 10   Lemon, juice-babyfood              0.010000   1.000  1.000

10002010 10   Lemon, peel                        0.010000   1.000  1.000

06032030 6C   Lentil, seed                       0.010000   1.000  1.000

04012040 4A   Lettuce, head                      3.000000   1.100  1.000
  1.1 factor to account for TMG metabolite

04012050 4A   Lettuce, leaf                      3.000000   1.100  1.000
  1.1 factor to account for TMG metabolite

10002060 10   Lime                               0.010000   1.000  1.000

10002070 10   Lime, juice                        0.010000   1.000  1.000

10002071 10   Lime, juice-babyfood               0.010000   1.000  1.000

13012080 13A  Loganberry                         0.040000   1.000  1.000

11002100 11   Loquat                             1.000000   1.000  1.000

14002130 14   Macadamia nut                      0.010000   1.000  1.000

95002150 O    Mango                              0.020000   1.000  1.000
  From thiamethoxam

95002151 O    Mango-babyfood                     0.020000   1.000  1.000
  From thiamethoxam

95002160 O    Mango, dried                       0.020000   1.000  1.000
  From thiamethoxam

95002170 O    Mango, juice                       0.020000   1.000  1.000
  From thiamethoxam

95002171 O    Mango, juice-babyfood              0.020000   1.000  1.000
  From thiamethoxam

28002210 M    Meat, game                         0.010000   1.000  1.000
  From thiamethoxam

27002220 D    Milk, fat                          0.010000   1.500  1.000
  1.5 factor to account for metabolites

27002221 D    Milk, fat - baby food/infant for   0.010000   1.500  1.000
  1.5 factor to account for metabolites

27012230 D    Milk, nonfat solids                0.010000   1.500  1.000
  1.5 factor to account for metabolites

27012231 D    Milk, nonfat solids-baby food/in   0.010000   1.500  1.000
  1.5 factor to account for metabolites

27022240 D    Milk, water                        0.010000   1.500  1.000
  1.5 factor to account for metabolites

27022241 D    Milk, water-babyfood/infant form   0.010000   1.500  1.000
  1.5 factor to account for metabolites

27032251 D    Milk, sugar (lactose)-baby food/   0.010000   1.500  1.000
  1.5 factor to account for metabolites

15002260 15   Millet, grain                      0.010000   1.000  1.000

05022290 5B   Mustard greens                     1.900000   1.000  1.000

12002300 12   Nectarine                          0.800000   1.000  1.000

15002310 15   Oat, bran                          0.010000   1.000  1.000

15002320 15   Oat, flour                         0.010000   1.000  1.000

15002321 15   Oat, flour-babyfood                0.010000   1.000  1.000

15002330 15   Oat, groats/rolled oats            0.010000   1.000  1.000

15002331 15   Oat, groats/rolled oats-babyfood   0.010000   1.000  1.000

08002340 8    Okra                               0.200000   1.000  1.000

03002370 3    Onion, dry bulb                    0.450000   1.000  1.000

03002371 3    Onion, dry bulb-babyfood           0.450000   1.000  1.000

03002380 3    Onion, dry bulb, dried             0.450000   9.000  1.000

03002381 3    Onion, dry bulb, dried-babyfood    0.450000   9.000  1.000

03002390 3    Onion, green                       0.450000   1.000  1.000

10002400 10   Orange                             0.010000   1.000  1.000

10002410 10   Orange, juice                      0.010000   1.000  1.000

10002411 10   Orange, juice-babyfood             0.010000   1.000  1.000

10002420 10   Orange, peel                       0.010000   1.000  1.000

95002450 O    Papaya                             0.020000   1.000  1.000
  From thiamethoxam

95002451 O    Papaya-babyfood                    0.020000   1.000  1.000
  From thiamethoxam

95002460 O    Papaya, dried                      0.020000   1.000  1.000
  From thiamethoxam

95002470 O    Papaya, juice                      0.020000   1.000  1.000
  From thiamethoxam

04012480 4A   Parsley, leaves                    3.000000   1.100  1.000
  1.1 factor to account for TMG metabolite

01012500 1AB  Parsley, turnip rooted             0.200000   1.000  1.000

01012510 1AB  Parsnip                            0.200000   1.000  1.000

01012511 1AB  Parsnip-babyfood                   0.200000   1.000  1.000

06022550 6B   Pea, succulent                     0.010000   1.000  1.000

06022551 6B   Pea, succulent-babyfood            0.010000   1.000  1.000

06032560 6C   Pea, dry                           0.010000   1.000  1.000

06032561 6C   Pea, dry-babyfood                  0.010000   1.000  1.000

06012570 6A   Pea, edible podded, succulent      0.010000   1.000  1.000

06032580 6C   Pea, pigeon, seed                  0.010000   1.000  1.000

06022590 6B   Pea, pigeon, succulent             0.010000   1.000  1.000

12002600 12   Peach                              0.800000   1.000  1.000

12002601 12   Peach-babyfood                     0.800000   1.000  1.000

12002610 12   Peach, dried                       0.800000   7.000  1.000

12002611 12   Peach, dried-babyfood              0.800000   7.000  1.000

12002620 12   Peach, juice                       0.800000   1.000  1.000

12002621 12   Peach, juice-babyfood              0.800000   1.000  1.000

11002660 11   Pear                               1.000000   1.000  1.000

11002661 11   Pear-babyfood                      1.000000   1.000  1.000

11002670 11   Pear, dried                        1.000000   6.250  1.000

11002680 11   Pear, juice                        1.000000   1.000  1.000

11002681 11   Pear, juice-babyfood               1.000000   1.000  1.000

14002690 14   Pecan                              0.010000   1.000  1.000

08002700 8    Pepper, bell                       0.200000   1.000  1.000

08002701 8    Pepper, bell-babyfood              0.200000   1.000  1.000

08002710 8    Pepper, bell, dried                0.200000   1.000  1.000

08002711 8    Pepper, bell, dried-babyfood       0.200000   1.000  1.000

08002720 8    Pepper, nonbell                    0.200000   1.000  1.000

08002721 8    Pepper, nonbell-babyfood           0.200000   1.000  1.000

08002730 8    Pepper, nonbell, dried             0.200000   1.000  1.000

95002750 O    Peppermint                         0.128000   1.000  1.000
  From thiamethoxam

95002760 O    Peppermint, oil                    0.128000   1.000  1.000
  From thiamethoxam

14002820 14   Pistachio                          0.010000   1.000  1.000

12002850 12   Plum                               0.800000   1.000  1.000

12002851 12   Plum-babyfood                      0.800000   1.000  1.000

12002860 12   Plum, prune, fresh                 0.800000   1.000  1.000

12002861 12   Plum, prune, fresh-babyfood        0.800000   1.000  1.000

12002870 12   Plum, prune, dried                 0.800000   5.000  1.000

12002871 12   Plum, prune, dried-babyfood        0.800000   5.000  1.000

12002880 12   Plum, prune, juice                 0.800000   1.400  1.000

12002881 12   Plum, prune, juice-babyfood        0.800000   1.400  1.000

95002890 O    Pomegranate                        0.200000   1.000  1.000
  From thiamethoxam

25002900 M    Pork, meat                         0.010000   1.000  1.000
  From thiamethoxam

25002901 M    Pork, meat-babyfood                0.010000   1.000  1.000
  From thiamethoxam

25002920 M    Pork, meat byproducts              0.010000   1.000  1.000
  From thiamethoxam

25002921 M    Pork, meat byproducts-babyfood     0.010000   1.000  1.000
  From thiamethoxam

25002940 M    Pork, kidney                       0.010000   1.000  1.000
  From thiamethoxam

25002950 M    Pork, liver                        0.010000   1.000  1.000
  From thiamethoxam

01032960 1C   Potato, chips                      0.600000   1.000  1.000

01032970 1C   Potato, dry (granules/ flakes)     1.500000   1.000  1.000

01032971 1C   Potato, dry (granules/ flakes)-b   1.500000   1.000  1.000

01032980 1C   Potato, flour                      0.300000   1.000  1.000

01032981 1C   Potato, flour-babyfood             0.300000   1.000  1.000

01032990 1C   Potato, tuber, w/peel              0.300000   1.000  1.000

01032991 1C   Potato, tuber, w/peel-babyfood     0.300000   1.000  1.000

01033000 1C   Potato, tuber, w/o peel            0.300000   1.000  1.000

01033001 1C   Potato, tuber, w/o peel-babyfood   0.300000   1.000  1.000

10003070 10   Pummelo                            0.010000   1.000  1.000

09023080 9B   Pumpkin                            0.060000   1.000  1.000

09023090 9B   Pumpkin, seed                      0.060000   1.000  1.000

11003100 11   Quince                             1.000000   1.000  1.000

29003120 M    Rabbit, meat                       0.010000   1.000  1.000
  From thiamethoxam

04013130 4A   Radicchio                          3.000000   1.100  1.000
  1.1 factor to account for TMG metabolite

01013140 1AB  Radish, roots                      0.200000   1.000  1.000

02003150 2    Radish, tops                       0.600000   1.000  1.000

01013160 1AB  Radish, Oriental, roots            0.200000   1.000  1.000

02003170 2    Radish, Oriental, tops             0.600000   1.000  1.000

05023180 5B   Rape greens                        1.900000   1.000  1.000

20003190 20   Rapeseed, oil                      0.010000   1.000  1.000

20003191 20   Rapeseed, oil-babyfood             0.010000   1.000  1.000

13013200 13A  Raspberry                          0.040000   1.000  1.000

13013201 13A  Raspberry-babyfood                 0.040000   1.000  1.000

13013210 13A  Raspberry, juice                   0.040000   1.000  1.000

13013211 13A  Raspberry, juice-babyfood          0.040000   1.000  1.000

04023220 4B   Rhubarb                            0.400000   1.000  1.000
  From Thiamethoxam

15003230 15   Rice, white                        0.010000   1.000  1.000
  From thiamethoxam

15003231 15   Rice, white-babyfood               0.010000   1.000  1.000
  From thiamethoxam

15003240 15   Rice, brown                        0.010000   1.000  1.000
  From thiamethoxam

15003241 15   Rice, brown-babyfood               0.010000   1.000  1.000
  From thiamethoxam

15003250 15   Rice, flour                        0.010000   1.000  1.000
  From thiamethoxam

15003251 15   Rice, flour-babyfood               0.010000   1.000  1.000
  From thiamethoxam

15003260 15   Rice, bran                         0.010000   1.000  1.000
  From thiamethoxam

15003261 15   Rice, bran-babyfood                0.010000   1.000  1.000
  From thiamethoxam

01013270 1AB  Rutabaga                           0.200000   1.000  1.000
  From thiamethoxam

15003280 15   Rye, grain                         0.010000   1.000  1.000

15003290 15   Rye, flour                         0.010000   1.000  1.000

20003300 20   Safflower, oil                     0.010000   1.000  1.000

20003301 20   Safflower, oil-babyfood            0.010000   1.000  1.000

01013310 1AB  Salsify, roots                     0.200000   1.000  1.000

02003320 2    Salsify, tops                      0.600000   1.000  1.000

95003330 O    Sapote, Mamey                      0.020000   1.000  1.000
  From thiamethoxam

03003380 3    Shallot                            0.450000   1.000  1.000

26003390 M    Sheep, meat                        0.010000   1.000  1.000
  From thiamethoxam

26003391 M    Sheep, meat-babyfood               0.010000   1.000  1.000
  From thiamethoxam

26003400 M    Sheep, meat byproducts             0.010000   1.000  1.000
  From thiamethoxam

26003420 M    Sheep, kidney                      0.010000   1.000  1.000
  From thiamethoxam

26003430 M    Sheep, liver                       0.010000   1.000  1.000
  From thiamethoxam

15003440 15   Sorghum, grain                     0.010000   1.000  1.000

15003450 15   Sorghum, syrup                     0.010000   1.000  1.000

06003470 6    Soybean, seed                      0.020000   1.000  1.000

06003480 6    Soybean, flour                     0.020000   1.000  1.000

06003481 6    Soybean, flour-babyfood            0.020000   1.000  1.000

06003490 6    Soybean, soy milk                  0.020000   1.000  1.000

06003491 6    Soybean, soy milk-babyfood or in   0.020000   1.000  1.000

06003500 6    Soybean, oil                       0.020000   1.000  1.000

06003501 6    Soybean, oil-babyfood              0.020000   1.000  1.000

95003520 O    Spearmint                          0.128000   1.000  1.000
  From thiamethoxam

95003530 O    Spearmint, oil                     0.128000   1.000  1.000
  From thiamethoxam

04013550 4A   Spinach                            3.000000   1.100  1.000
  1.1 factor to account for TMG metabolite

04013551 4A   Spinach-babyfood                   3.000000   1.100  1.000
  1.1 factor to account for TMG metabolite

09023560 9B   Squash, summer                     0.060000   1.000  1.000

09023561 9B   Squash, summer-babyfood            0.060000   1.000  1.000

09023570 9B   Squash, winter                     0.060000   1.000  1.000

09023571 9B   Squash, winter-babyfood            0.060000   1.000  1.000

95003590 O    Strawberry                         0.050000   1.000  1.000
  From thiamethoxam

95003591 O    Strawberry-babyfood                0.050000   1.000  1.000
  From thiamethoxam

95003600 O    Strawberry, juice                  0.050000   1.000  1.000
  From thiamethoxam

95003601 O    Strawberry, juice-babyfood         0.050000   1.000  1.000
  From thiamethoxam

20003640 20   Sunflower, seed                    0.010000   1.000  1.000

20003650 20   Sunflower, oil                     0.010000   1.000  1.000

20003651 20   Sunflower, oil-babyfood            0.010000   1.000  1.000

01033660 1CD  Sweet potato                       0.300000   1.000  1.000

01033661 1CD  Sweet potato-babyfood              0.300000   1.000  1.000

04023670 4B   Swiss chard                        0.400000   1.000  1.000
  From Thiamethoxam

10003690 10   Tangerine                          0.010000   1.000  1.000

10003700 10   Tangerine, juice                   0.010000   1.000  1.000

01033710 1CD  Tanier, corm                       0.300000   1.000  1.000

08003740 8    Tomatillo                          0.200000   1.000  1.000

08003750 8    Tomato                             0.200000   1.000  1.000

08003751 8    Tomato-babyfood                    0.200000   1.000  1.000

08003760 8    Tomato, paste                      0.200000   5.400  1.000

08003761 8    Tomato, paste-babyfood             0.200000   5.400  1.000

08003770 8    Tomato, puree                      0.200000   3.300  1.000

08003771 8    Tomato, puree-babyfood             0.200000   3.300  1.000

08003780 8    Tomato, dried                      0.200000  14.300  1.000

08003781 8    Tomato, dried-babyfood             0.200000  14.300  1.000

08003790 8    Tomato, juice                      0.200000   1.500  1.000

15003810 15   Triticale, flour                   0.010000   1.000  1.000

15003811 15   Triticale, flour-babyfood          0.010000   1.000  1.000

01033870 1CD  Turmeric                           0.300000   1.000  1.000

01013880 1AB  Turnip, roots                      0.200000   1.000  1.000

05023890 5B   Turnip, greens                     1.900000   1.000  1.000

14003910 14   Walnut                             0.010000   1.000  1.000

86010000 O    Water, direct, all sources         0.007290   1.000  1.000

86020000 O    Water, indirect, all sources       0.007290   1.000  1.000

09013990 9A   Watermelon                         0.060000   1.000  1.000

09014000 9A   Watermelon, juice                  0.060000   1.000  1.000

15004010 15   Wheat, grain                       0.010000   1.000  1.000

15004011 15   Wheat, grain-babyfood              0.010000   1.000  1.000

15004020 15   Wheat, flour                       0.010000   1.000  1.000

15004021 15   Wheat, flour-babyfood              0.010000   1.000  1.000

15004030 15   Wheat, germ                        0.010000   1.000  1.000

15004040 15   Wheat, bran                        0.010000   1.000  1.000

15004050 15   Wild rice                          0.010000   1.000  1.000
  From thiamethoxam

01034060 1CD  Yam, true                          0.300000   1.000  1.000

01034070 1CD  Yam bean                           0.300000   1.000  1.000

Attachment 2.  Inputs for the Chronic Dietary Exposure Assessment of
Clothianidin.

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for CLOTHIANIDIN                      
1994-98 data

Residue file: C:\Documents and Settings\mdoherty\My Documents\Chemistry
Reviews\!DEEM Runs\Clothianidin and Thiamethoxam\2009\044309 (2009)
Chronic.R98

                                                           Adjust. #2
NOT used

Analysis Date 07-29-2009             Residue file dated:
07-29-2009/13:09:54/8

Reference dose (RfD) = 0.098 mg/kg bw/day

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

14000030 14   Almond                             0.010000   1.000     
1.000   

14000031 14   Almond-babyfood                    0.010000   1.000     
1.000   

14000040 14   Almond, oil                        0.010000   1.000     
1.000   

14000041 14   Almond, oil-babyfood               0.010000   1.000     
1.000   

04010050 4A   Amaranth, leafy                    3.000000   1.100     
1.000   1.1 factor to account for TMG metabolite

11000070 11   Apple, fruit with peel             1.000000   1.000     
1.000   

11000080 11   Apple, peeled fruit                1.000000   1.000     
1.000   

11000081 11   Apple, peeled fruit-babyfood       1.000000   1.000     
1.000   

11000090 11   Apple, dried                       1.000000   8.000     
1.000   

11000091 11   Apple, dried-babyfood              1.000000   8.000     
1.000   

11000100 11   Apple, juice                       1.000000   1.300     
1.000   

11000101 11   Apple, juice-babyfood              1.000000   1.300     
1.000   

11000110 11   Apple, sauce                       1.000000   1.000     
1.000   

11000111 11   Apple, sauce-babyfood              1.000000   1.000     
1.000   

12000120 12   Apricot                            0.800000   1.000     
1.000   

12000121 12   Apricot-babyfood                   0.800000   1.000     
1.000   

12000130 12   Apricot, dried                     0.800000   6.000     
1.000   

12000140 12   Apricot, juice                     0.800000   1.000     
1.000   

12000141 12   Apricot, juice-babyfood            0.800000   1.000     
1.000   

01030150 1CD  Arrowroot, flour                   0.300000   1.000     
1.000   

01030151 1CD  Arrowroot, flour-babyfood          0.300000   1.000     
1.000   

95000160 O    Artichoke, globe                   0.029000   1.000     
1.000   From thiamethoxam

01030170 1CD  Artichoke, Jerusalem               0.300000   1.000     
1.000   

04010180 4A   Arugula                            3.000000   1.100     
1.000   1.1 factor to account for TMG metabolite

95000200 O    Avocado                            0.020000   1.000     
1.000   From thiamethoxam

09020210 9B   Balsam pear                        0.060000   1.000     
1.000   

15000250 15   Barley, pearled barley             0.020000   1.000     
1.000   

15000251 15   Barley, pearled barley-babyfood    0.020000   1.000     
1.000   

15000260 15   Barley, flour                      0.020000   1.000     
1.000   

15000261 15   Barley, flour-babyfood             0.020000   1.000     
1.000   

15000270 15   Barley, bran                       0.020000   1.000     
1.000   

06030300 6C   Bean, black, seed                  0.010000   1.000     
1.000   

06020310 6B   Bean, broad, succulent             0.010000   1.000     
1.000   

06030320 6C   Bean, broad, seed                  0.010000   1.000     
1.000   

06020330 6B   Bean, cowpea, succulent            0.010000   1.000     
1.000   

06030340 6C   Bean, cowpea, seed                 0.010000   1.000     
1.000   

06030350 6C   Bean,  great northern, seed        0.010000   1.000     
1.000   

06030360 6C   Bean, kidney, seed                 0.010000   1.000     
1.000   

06020370 6B   Bean, lima, succulent              0.010000   1.000     
1.000   

06030380 6C   Bean, lima, seed                   0.010000   1.000     
1.000   

06030390 6C   Bean, mung, seed                   0.010000   1.000     
1.000   

06030400 6C   Bean, navy, seed                   0.010000   1.000     
1.000   

06030410 6C   Bean, pink, seed                   0.010000   1.000     
1.000   

06030420 6C   Bean, pinto, seed                  0.010000   1.000     
1.000   

06010430 6A   Bean, snap, succulent              0.010000   1.000     
1.000   

06010431 6A   Bean, snap, succulent-babyfood     0.010000   1.000     
1.000   

21000440 M    Beef, meat                         0.010000   1.000     
1.000   From thiamethoxam

21000441 M    Beef, meat-babyfood                0.010000   1.000     
1.000   From thiamethoxam

21000450 M    Beef, meat, dried                  0.010000   1.920     
1.000   From thiamethoxam

21000460 M    Beef, meat byproducts              0.010000   1.000     
1.000   From thiamethoxam

21000461 M    Beef, meat byproducts-babyfood     0.010000   1.000     
1.000   From thiamethoxam

21000480 M    Beef, kidney                       0.010000   1.000     
1.000   From thiamethoxam

21000490 M    Beef, liver                        0.010000   1.000     
1.000   From thiamethoxam

21000491 M    Beef, liver-babyfood               0.010000   1.000     
1.000   From thiamethoxam

01010500 1AB  Beet, garden, roots                0.200000   1.000     
1.000   

01010501 1AB  Beet, garden, roots-babyfood       0.200000   1.000     
1.000   

02000510 2    Beet, garden, tops                 0.600000   1.000     
1.000   

01010520 1A   Beet, sugar                        0.020000   1.000     
1.000   

01010521 1A   Beet, sugar-babyfood               0.020000   1.000     
1.000   

01010530 1A   Beet, sugar, molasses              0.020000   2.900     
1.000   

01010531 1A   Beet, sugar, molasses-babyfood     0.020000   2.900     
1.000   

13010550 13A  Blackberry                         0.040000   1.000     
1.000   

13010560 13A  Blackberry, juice                  0.040000   1.000     
1.000   

13010561 13A  Blackberry, juice-babyfood         0.040000   1.000     
1.000   

13020570 13B  Blueberry                          0.050000   1.000     
1.000   

13020571 13B  Blueberry-babyfood                 0.050000   1.000     
1.000   

13010580 13A  Boysenberry                        0.040000   1.000     
1.000   

14000590 14   Brazil nut                         0.010000   1.000     
1.000   

05010610 5A   Broccoli                           1.900000   1.000     
1.000   

05010611 5A   Broccoli-babyfood                  1.900000   1.000     
1.000   

05010620 5A   Broccoli, Chinese                  1.900000   1.000     
1.000   

05020630 5B   Broccoli raab                      1.900000   1.000     
1.000   

05010640 5A   Brussels sprouts                   1.900000   1.000     
1.000   

01010670 1AB  Burdock                            0.200000   1.000     
1.000   

14000680 14   Butternut                          0.010000   1.000     
1.000   

05010690 5A   Cabbage                            1.900000   1.000     
1.000   

05020700 5B   Cabbage, Chinese, bok choy         1.900000   1.000     
1.000   

05010710 5A   Cabbage, Chinese, napa             1.900000   1.000     
1.000   

05010720 5A   Cabbage, Chinese, mustard          1.900000   1.000     
1.000   

09010750 9A   Cantaloupe                         0.060000   1.000     
1.000   

04020760 4B   Cardoon                            0.400000   1.000     
1.000   From Thiamethoxam

01010780 1AB  Carrot                             0.200000   1.000     
1.000   

01010781 1AB  Carrot-babyfood                    0.200000   1.000     
1.000   

01010790 1AB  Carrot, juice                      0.200000   1.000     
1.000   

09010800 9A   Casaba                             0.060000   1.000     
1.000   

14000810 14   Cashew                             0.010000   1.000     
1.000   

01030820 1CD  Cassava                            0.300000   1.000     
1.000   

01030821 1CD  Cassava-babyfood                   0.300000   1.000     
1.000   

05010830 5A   Cauliflower                        1.900000   1.000     
1.000   

01010840 1AB  Celeriac                           0.200000   1.000     
1.000   

04020850 4B   Celery                             0.400000   1.000     
1.000   From Thiamethoxam

04020851 4B   Celery-babyfood                    0.400000   1.000     
1.000   From Thiamethoxam

04020860 4B   Celery, juice                      0.400000   1.000     
1.000   From Thiamethoxam

04020870 4B   Celtuce                            0.400000   1.000     
1.000   From Thiamethoxam

09020880 9B   Chayote, fruit                     0.060000   1.000     
1.000   

12000900 12   Cherry                             0.800000   1.000     
1.000   

12000901 12   Cherry-babyfood                    0.800000   1.000     
1.000   

12000910 12   Cherry, juice                      0.800000   1.500     
1.000   

12000911 12   Cherry, juice-babyfood             0.800000   1.500     
1.000   

14000920 14   Chestnut                           0.010000   1.000     
1.000   

06030980 6C   Chickpea, seed                     0.010000   1.000     
1.000   

06030981 6C   Chickpea, seed-babyfood            0.010000   1.000     
1.000   

06030990 6C   Chickpea, flour                    0.010000   1.000     
1.000   

01011000 1AB  Chicory, roots                     0.200000   1.000     
1.000   

02001010 2    Chicory, tops                      0.600000   1.000     
1.000   

09021020 9B   Chinese waxgourd                   0.060000   1.000     
1.000   

04011040 4A   Chrysanthemum, garland             3.000000   1.100     
1.000   1.1 factor to account for TMG metabolite

10001060 10   Citrus citron                      0.010000   1.000     
1.000   

10001070 10   Citrus hybrids                     0.010000   1.000     
1.000   

10001080 10   Citrus, oil                        0.010000   1.000     
1.000   

95001150 O    Coffee, roasted bean               0.010000   1.000     
1.000   From thiamethoxam

95001160 O    Coffee, instant                    0.010000   1.000     
1.000   From thiamethoxam

05021170 5B   Collards                           1.900000   1.000     
1.000   

15001200 15   Corn, field, flour                 0.010000   1.000     
1.000   

15001201 15   Corn, field, flour-babyfood        0.010000   1.000     
1.000   

15001210 15   Corn, field, meal                  0.010000   1.000     
1.000   

15001211 15   Corn, field, meal-babyfood         0.010000   1.000     
1.000   

15001220 15   Corn, field, bran                  0.010000   1.000     
1.000   

15001230 15   Corn, field, starch                0.010000   1.000     
1.000   

15001231 15   Corn, field, starch-babyfood       0.010000   1.000     
1.000   

15001240 15   Corn, field, syrup                 0.010000   1.000     
1.000   

15001241 15   Corn, field, syrup-babyfood        0.010000   1.000     
1.000   

15001250 15   Corn, field, oil                   0.010000   1.000     
1.000   

15001251 15   Corn, field, oil-babyfood          0.010000   1.000     
1.000   

15001260 15   Corn, pop                          0.010000   1.000     
1.000   

15001270 15   Corn, sweet                        0.010000   1.000     
1.000   

15001271 15   Corn, sweet-babyfood               0.010000   1.000     
1.000   

95001280 O    Cottonseed, oil                    0.200000   1.000     
1.000   

95001281 O    Cottonseed, oil-babyfood           0.200000   1.000     
1.000   

11001290 11   Crabapple                          1.000000   1.000     
1.000   

95001300 O    Cranberry                          0.010000   1.000     
1.000   

95001301 O    Cranberry-babyfood                 0.010000   1.000     
1.000   

95001310 O    Cranberry, dried                   0.010000   1.000     
1.000   

95001320 O    Cranberry, juice                   0.010000   1.100     
1.000   

95001321 O    Cranberry, juice-babyfood          0.010000   1.100     
1.000   

04011330 4A   Cress, garden                      3.000000   1.100     
1.000   1.1 factor to account for TMG metabolite

04011340 4A   Cress, upland                      3.000000   1.100     
1.000   1.1 factor to account for TMG metabolite

09021350 9B   Cucumber                           0.060000   1.000     
1.000   

13021360 13B  Currant                            0.050000   1.000     
1.000   

13021370 13B  Currant, dried                     0.050000   1.000     
1.000   

04011380 4A   Dandelion, leaves                  3.000000   1.100     
1.000   1.1 factor to account for TMG metabolite

01031390 1CD  Dasheen, corm                      0.300000   1.000     
1.000   

02001400 2    Dasheen, leaves                    0.600000   1.000     
1.000   

13011420 13A  Dewberry                           0.040000   1.000     
1.000   

08001480 8    Eggplant                           0.200000   1.000     
1.000   

13021490 13B  Elderberry                         0.050000   1.000     
1.000   

04011500 4A   Endive                             3.000000   1.100     
1.000   1.1 factor to account for TMG metabolite

04021520 4B   Fennel, Florence                   0.400000   1.000     
1.000   From Thiamethoxam

95001530 O    Fig                                0.050000   1.000     
1.000   

95001540 O    Fig, dried                         0.050000   1.000     
1.000   

14001550 14   Filbert                            0.010000   1.000     
1.000   

14001560 14   Filbert, oil                       0.010000   1.000     
1.000   

20001630 20   Flaxseed, oil                      0.010000   1.000     
1.000   

03001640 3    Garlic                             0.450000   1.000     
1.000   

03001650 3    Garlic, dried                      0.450000   1.000     
1.000   

03001651 3    Garlic, dried-babyfood             0.450000   1.000     
1.000   

01031660 1CD  Ginger                             0.300000   1.000     
1.000   

01031661 1CD  Ginger-babyfood                    0.300000   1.000     
1.000   

01031670 1CD  Ginger, dried                      0.300000   1.000     
1.000   

01011680 1AB  Ginseng, dried                     0.200000   1.000     
1.000   

23001690 M    Goat, meat                         0.010000   1.000     
1.000   From thiamethoxam

23001700 M    Goat, meat byproducts              0.010000   1.000     
1.000   From thiamethoxam

23001720 M    Goat, kidney                       0.010000   1.000     
1.000   From thiamethoxam

23001730 M    Goat, liver                        0.010000   1.000     
1.000   From thiamethoxam

13021740 13B  Gooseberry                         0.050000   1.000     
1.000   

95001750 O    Grape                              0.600000   1.000     
1.000   

95001760 O    Grape, juice                       0.600000   1.200     
1.000   

95001761 O    Grape, juice-babyfood              0.600000   1.200     
1.000   

95001770 O    Grape, leaves                      0.600000   1.000     
1.000   

95001780 O    Grape, raisin                      0.600000   2.500     
1.000   

95001790 O    Grape, wine and sherry             0.600000   1.200     
1.000   

10001800 10   Grapefruit                         0.010000   1.000     
1.000   

10001810 10   Grapefruit, juice                  0.010000   1.000     
1.000   

06031820 6C   Guar, seed                         0.010000   1.000     
1.000   

06031821 6C   Guar, seed-babyfood                0.010000   1.000     
1.000   

14001850 14   Hickory nut                        0.010000   1.000     
1.000   

09011870 9A   Honeydew melon                     0.060000   1.000     
1.000   

95001880 O    Hop                                0.028000   1.000     
1.000   From thiamethoxam

24001890 M    Horse, meat                        0.010000   1.000     
1.000   From thiamethoxam

01011900 1AB  Horseradish                        0.200000   1.000     
1.000   

13021910 13B  Huckleberry                        0.050000   1.000     
1.000   

05021940 5B   Kale                               1.900000   1.000     
1.000   

05011960 5A   Kohlrabi                           1.900000   1.000     
1.000   

10001970 10   Kumquat                            0.010000   1.000     
1.000   

03001980 3    Leek                               0.450000   1.000     
1.000   

10001990 10   Lemon                              0.010000   1.000     
1.000   

10002000 10   Lemon, juice                       0.010000   1.000     
1.000   

10002001 10   Lemon, juice-babyfood              0.010000   1.000     
1.000   

10002010 10   Lemon, peel                        0.010000   1.000     
1.000   

06032030 6C   Lentil, seed                       0.010000   1.000     
1.000   

04012040 4A   Lettuce, head                      3.000000   1.100     
1.000   1.1 factor to account for TMG metabolite

04012050 4A   Lettuce, leaf                      3.000000   1.100     
1.000   1.1 factor to account for TMG metabolite

10002060 10   Lime                               0.010000   1.000     
1.000   

10002070 10   Lime, juice                        0.010000   1.000     
1.000   

10002071 10   Lime, juice-babyfood               0.010000   1.000     
1.000   

13012080 13A  Loganberry                         0.040000   1.000     
1.000   

11002100 11   Loquat                             1.000000   1.000     
1.000   

14002130 14   Macadamia nut                      0.010000   1.000     
1.000   

95002150 O    Mango                              0.020000   1.000     
1.000   From thiamethoxam

95002151 O    Mango-babyfood                     0.020000   1.000     
1.000   From thiamethoxam

95002160 O    Mango, dried                       0.020000   1.000     
1.000   From thiamethoxam

95002170 O    Mango, juice                       0.020000   1.000     
1.000   From thiamethoxam

95002171 O    Mango, juice-babyfood              0.020000   1.000     
1.000   From thiamethoxam

28002210 M    Meat, game                         0.010000   1.000     
1.000   From thiamethoxam

27002220 D    Milk, fat                          0.010000   1.500     
1.000   1.5 factor to account for metabolites

27002221 D    Milk, fat - baby food/infant for   0.010000   1.500     
1.000   1.5 factor to account for metabolites

27012230 D    Milk, nonfat solids                0.010000   1.500     
1.000   1.5 factor to account for metabolites

27012231 D    Milk, nonfat solids-baby food/in   0.010000   1.500     
1.000   1.5 factor to account for metabolites

27022240 D    Milk, water                        0.010000   1.500     
1.000   1.5 factor to account for metabolites

27022241 D    Milk, water-babyfood/infant form   0.010000   1.500     
1.000   1.5 factor to account for metabolites

27032251 D    Milk, sugar (lactose)-baby food/   0.010000   1.500     
1.000   1.5 factor to account for metabolites

15002260 15   Millet, grain                      0.010000   1.000     
1.000   

05022290 5B   Mustard greens                     1.900000   1.000     
1.000   

12002300 12   Nectarine                          0.800000   1.000     
1.000   

15002310 15   Oat, bran                          0.010000   1.000     
1.000   

15002320 15   Oat, flour                         0.010000   1.000     
1.000   

15002321 15   Oat, flour-babyfood                0.010000   1.000     
1.000   

15002330 15   Oat, groats/rolled oats            0.010000   1.000     
1.000   

15002331 15   Oat, groats/rolled oats-babyfood   0.010000   1.000     
1.000   

08002340 8    Okra                               0.200000   1.000     
1.000   

03002370 3    Onion, dry bulb                    0.450000   1.000     
1.000   

03002371 3    Onion, dry bulb-babyfood           0.450000   1.000     
1.000   

03002380 3    Onion, dry bulb, dried             0.450000   9.000     
1.000   

03002381 3    Onion, dry bulb, dried-babyfood    0.450000   9.000     
1.000   

03002390 3    Onion, green                       0.450000   1.000     
1.000   

10002400 10   Orange                             0.010000   1.000     
1.000   

10002410 10   Orange, juice                      0.010000   1.000     
1.000   

10002411 10   Orange, juice-babyfood             0.010000   1.000     
1.000   

10002420 10   Orange, peel                       0.010000   1.000     
1.000   

95002450 O    Papaya                             0.020000   1.000     
1.000   From thiamethoxam

95002451 O    Papaya-babyfood                    0.020000   1.000     
1.000   From thiamethoxam

95002460 O    Papaya, dried                      0.020000   1.000     
1.000   From thiamethoxam

95002470 O    Papaya, juice                      0.020000   1.000     
1.000   From thiamethoxam

04012480 4A   Parsley, leaves                    3.000000   1.100     
1.000   1.1 factor to account for TMG metabolite

01012500 1AB  Parsley, turnip rooted             0.200000   1.000     
1.000   

01012510 1AB  Parsnip                            0.200000   1.000     
1.000   

01012511 1AB  Parsnip-babyfood                   0.200000   1.000     
1.000   

06022550 6B   Pea, succulent                     0.010000   1.000     
1.000   

06022551 6B   Pea, succulent-babyfood            0.010000   1.000     
1.000   

06032560 6C   Pea, dry                           0.010000   1.000     
1.000   

06032561 6C   Pea, dry-babyfood                  0.010000   1.000     
1.000   

06012570 6A   Pea, edible podded, succulent      0.010000   1.000     
1.000   

06032580 6C   Pea, pigeon, seed                  0.010000   1.000     
1.000   

06022590 6B   Pea, pigeon, succulent             0.010000   1.000     
1.000   

12002600 12   Peach                              0.800000   1.000     
1.000   

12002601 12   Peach-babyfood                     0.800000   1.000     
1.000   

12002610 12   Peach, dried                       0.800000   7.000     
1.000   

12002611 12   Peach, dried-babyfood              0.800000   7.000     
1.000   

12002620 12   Peach, juice                       0.800000   1.000     
1.000   

12002621 12   Peach, juice-babyfood              0.800000   1.000     
1.000   

11002660 11   Pear                               1.000000   1.000     
1.000   

11002661 11   Pear-babyfood                      1.000000   1.000     
1.000   

11002670 11   Pear, dried                        1.000000   6.250     
1.000   

11002680 11   Pear, juice                        1.000000   1.000     
1.000   

11002681 11   Pear, juice-babyfood               1.000000   1.000     
1.000   

14002690 14   Pecan                              0.010000   1.000     
1.000   

08002700 8    Pepper, bell                       0.200000   1.000     
1.000   

08002701 8    Pepper, bell-babyfood              0.200000   1.000     
1.000   

08002710 8    Pepper, bell, dried                0.200000   1.000     
1.000   

08002711 8    Pepper, bell, dried-babyfood       0.200000   1.000     
1.000   

08002720 8    Pepper, nonbell                    0.200000   1.000     
1.000   

08002721 8    Pepper, nonbell-babyfood           0.200000   1.000     
1.000   

08002730 8    Pepper, nonbell, dried             0.200000   1.000     
1.000   

95002750 O    Peppermint                         0.128000   1.000     
1.000   From thiamethoxam

95002760 O    Peppermint, oil                    0.128000   1.000     
1.000   From thiamethoxam

14002820 14   Pistachio                          0.010000   1.000     
1.000   

12002850 12   Plum                               0.800000   1.000     
1.000   

12002851 12   Plum-babyfood                      0.800000   1.000     
1.000   

12002860 12   Plum, prune, fresh                 0.800000   1.000     
1.000   

12002861 12   Plum, prune, fresh-babyfood        0.800000   1.000     
1.000   

12002870 12   Plum, prune, dried                 0.800000   5.000     
1.000   

12002871 12   Plum, prune, dried-babyfood        0.800000   5.000     
1.000   

12002880 12   Plum, prune, juice                 0.800000   1.400     
1.000   

12002881 12   Plum, prune, juice-babyfood        0.800000   1.400     
1.000   

95002890 O    Pomegranate                        0.200000   1.000     
1.000   From thiamethoxam

25002900 M    Pork, meat                         0.010000   1.000     
1.000   From thiamethoxam

25002901 M    Pork, meat-babyfood                0.010000   1.000     
1.000   From thiamethoxam

25002920 M    Pork, meat byproducts              0.010000   1.000     
1.000   From thiamethoxam

25002921 M    Pork, meat byproducts-babyfood     0.010000   1.000     
1.000   From thiamethoxam

25002940 M    Pork, kidney                       0.010000   1.000     
1.000   From thiamethoxam

25002950 M    Pork, liver                        0.010000   1.000     
1.000   From thiamethoxam

01032960 1C   Potato, chips                      0.600000   1.000     
1.000   

01032970 1C   Potato, dry (granules/ flakes)     1.500000   1.000     
1.000   

01032971 1C   Potato, dry (granules/ flakes)-b   1.500000   1.000     
1.000   

01032980 1C   Potato, flour                      0.300000   1.000     
1.000   

01032981 1C   Potato, flour-babyfood             0.300000   1.000     
1.000   

01032990 1C   Potato, tuber, w/peel              0.300000   1.000     
1.000   

01032991 1C   Potato, tuber, w/peel-babyfood     0.300000   1.000     
1.000   

01033000 1C   Potato, tuber, w/o peel            0.300000   1.000     
1.000   

01033001 1C   Potato, tuber, w/o peel-babyfood   0.300000   1.000     
1.000   

10003070 10   Pummelo                            0.010000   1.000     
1.000   

09023080 9B   Pumpkin                            0.060000   1.000     
1.000   

09023090 9B   Pumpkin, seed                      0.060000   1.000     
1.000   

11003100 11   Quince                             1.000000   1.000     
1.000   

29003120 M    Rabbit, meat                       0.010000   1.000     
1.000   From thiamethoxam

04013130 4A   Radicchio                          3.000000   1.100     
1.000   1.1 factor to account for TMG metabolite

01013140 1AB  Radish, roots                      0.200000   1.000     
1.000   

02003150 2    Radish, tops                       0.600000   1.000     
1.000   

01013160 1AB  Radish, Oriental, roots            0.200000   1.000     
1.000   

02003170 2    Radish, Oriental, tops             0.600000   1.000     
1.000   

05023180 5B   Rape greens                        1.900000   1.000     
1.000   

20003190 20   Rapeseed, oil                      0.010000   1.000     
1.000   

20003191 20   Rapeseed, oil-babyfood             0.010000   1.000     
1.000   

13013200 13A  Raspberry                          0.040000   1.000     
1.000   

13013201 13A  Raspberry-babyfood                 0.040000   1.000     
1.000   

13013210 13A  Raspberry, juice                   0.040000   1.000     
1.000   

13013211 13A  Raspberry, juice-babyfood          0.040000   1.000     
1.000   

04023220 4B   Rhubarb                            0.400000   1.000     
1.000   From Thiamethoxam

15003230 15   Rice, white                        0.010000   1.000     
1.000   From thiamethoxam

15003231 15   Rice, white-babyfood               0.010000   1.000     
1.000   From thiamethoxam

15003240 15   Rice, brown                        0.010000   1.000     
1.000   From thiamethoxam

15003241 15   Rice, brown-babyfood               0.010000   1.000     
1.000   From thiamethoxam

15003250 15   Rice, flour                        0.010000   1.000     
1.000   From thiamethoxam

15003251 15   Rice, flour-babyfood               0.010000   1.000     
1.000   From thiamethoxam

15003260 15   Rice, bran                         0.010000   1.000     
1.000   From thiamethoxam

15003261 15   Rice, bran-babyfood                0.010000   1.000     
1.000   From thiamethoxam

01013270 1AB  Rutabaga                           0.200000   1.000     
1.000   From thiamethoxam

15003280 15   Rye, grain                         0.010000   1.000     
1.000   

15003290 15   Rye, flour                         0.010000   1.000     
1.000   

20003300 20   Safflower, oil                     0.010000   1.000     
1.000   

20003301 20   Safflower, oil-babyfood            0.010000   1.000     
1.000   

01013310 1AB  Salsify, roots                     0.200000   1.000     
1.000   

02003320 2    Salsify, tops                      0.600000   1.000     
1.000   

95003330 O    Sapote, Mamey                      0.020000   1.000     
1.000   From thiamethoxam

03003380 3    Shallot                            0.450000   1.000     
1.000   

26003390 M    Sheep, meat                        0.010000   1.000     
1.000   From thiamethoxam

26003391 M    Sheep, meat-babyfood               0.010000   1.000     
1.000   From thiamethoxam

26003400 M    Sheep, meat byproducts             0.010000   1.000     
1.000   From thiamethoxam

26003420 M    Sheep, kidney                      0.010000   1.000     
1.000   From thiamethoxam

26003430 M    Sheep, liver                       0.010000   1.000     
1.000   From thiamethoxam

15003440 15   Sorghum, grain                     0.010000   1.000     
1.000   

15003450 15   Sorghum, syrup                     0.010000   1.000     
1.000   

06003470 6    Soybean, seed                      0.020000   1.000     
1.000   

06003480 6    Soybean, flour                     0.020000   1.000     
1.000   

06003481 6    Soybean, flour-babyfood            0.020000   1.000     
1.000   

06003490 6    Soybean, soy milk                  0.020000   1.000     
1.000   

06003491 6    Soybean, soy milk-babyfood or in   0.020000   1.000     
1.000   

06003500 6    Soybean, oil                       0.020000   1.000     
1.000   

06003501 6    Soybean, oil-babyfood              0.020000   1.000     
1.000   

95003520 O    Spearmint                          0.128000   1.000     
1.000   From thiamethoxam

95003530 O    Spearmint, oil                     0.128000   1.000     
1.000   From thiamethoxam

04013550 4A   Spinach                            3.000000   1.100     
1.000   1.1 factor to account for TMG metabolite

04013551 4A   Spinach-babyfood                   3.000000   1.100     
1.000   1.1 factor to account for TMG metabolite

09023560 9B   Squash, summer                     0.060000   1.000     
1.000   

09023561 9B   Squash, summer-babyfood            0.060000   1.000     
1.000   

09023570 9B   Squash, winter                     0.060000   1.000     
1.000   

09023571 9B   Squash, winter-babyfood            0.060000   1.000     
1.000   

95003590 O    Strawberry                         0.050000   1.000     
1.000   From thiamethoxam

95003591 O    Strawberry-babyfood                0.050000   1.000     
1.000   From thiamethoxam

95003600 O    Strawberry, juice                  0.050000   1.000     
1.000   From thiamethoxam

95003601 O    Strawberry, juice-babyfood         0.050000   1.000     
1.000   From thiamethoxam

20003640 20   Sunflower, seed                    0.010000   1.000     
1.000   

20003650 20   Sunflower, oil                     0.010000   1.000     
1.000   

20003651 20   Sunflower, oil-babyfood            0.010000   1.000     
1.000   

01033660 1CD  Sweet potato                       0.300000   1.000     
1.000   

01033661 1CD  Sweet potato-babyfood              0.300000   1.000     
1.000   

04023670 4B   Swiss chard                        0.400000   1.000     
1.000   From Thiamethoxam

10003690 10   Tangerine                          0.010000   1.000     
1.000   

10003700 10   Tangerine, juice                   0.010000   1.000     
1.000   

01033710 1CD  Tanier, corm                       0.300000   1.000     
1.000   

08003740 8    Tomatillo                          0.200000   1.000     
1.000   

08003750 8    Tomato                             0.200000   1.000     
1.000   

08003751 8    Tomato-babyfood                    0.200000   1.000     
1.000   

08003760 8    Tomato, paste                      0.200000   5.400     
1.000   

08003761 8    Tomato, paste-babyfood             0.200000   5.400     
1.000   

08003770 8    Tomato, puree                      0.200000   3.300     
1.000   

08003771 8    Tomato, puree-babyfood             0.200000   3.300     
1.000   

08003780 8    Tomato, dried                      0.200000  14.300     
1.000   

08003781 8    Tomato, dried-babyfood             0.200000  14.300     
1.000   

08003790 8    Tomato, juice                      0.200000   1.500     
1.000   

15003810 15   Triticale, flour                   0.010000   1.000     
1.000   

15003811 15   Triticale, flour-babyfood          0.010000   1.000     
1.000   

01033870 1CD  Turmeric                           0.300000   1.000     
1.000   

01013880 1AB  Turnip, roots                      0.200000   1.000     
1.000   

05023890 5B   Turnip, greens                     1.900000   1.000     
1.000   

14003910 14   Walnut                             0.010000   1.000     
1.000   

86010000 O    Water, direct, all sources         0.005880   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.005880   1.000     
1.000   

09013990 9A   Watermelon                         0.060000   1.000     
1.000   

09014000 9A   Watermelon, juice                  0.060000   1.000     
1.000   

15004010 15   Wheat, grain                       0.010000   1.000     
1.000   

15004011 15   Wheat, grain-babyfood              0.010000   1.000     
1.000   

15004020 15   Wheat, flour                       0.010000   1.000     
1.000   

15004021 15   Wheat, flour-babyfood              0.010000   1.000     
1.000   

15004030 15   Wheat, germ                        0.010000   1.000     
1.000   

15004040 15   Wheat, bran                        0.010000   1.000     
1.000   

15004050 15   Wild rice                          0.010000   1.000     
1.000   From thiamethoxam

01034060 1CD  Yam, true                          0.300000   1.000     
1.000   

01034070 1CD  Yam bean                           0.300000   1.000     
1.000   

Attachment 3.  Summary of the Results of the Acute Dietary Exposure
Assessment of Clothianidin.

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for CLOTHIANIDIN                       
(1994-98 data)

Residue file: 044309 (2009) Acute.R98             Adjustment factor #2
NOT used.

Analysis Date: 07-29-2009/13:14:18    Residue file dated:
07-29-2009/13:08:25/8

Daily totals for food and foodform consumption used.

Run Comment: ""

========================================================================
=======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
--------

U.S. Population:

                    0.015019     6.01    0.035786    14.31    0.080200  
 32.08 

All infants:

                    0.048266    19.31    0.083300    33.32    0.202858  
 81.14 

Children 1-2 yrs:

                    0.057317    22.93    0.096206    38.48    0.176286  
 70.51 

Children 3-5 yrs:

                    0.039089    15.64    0.063574    25.43    0.111648  
 44.66 

Children 6-12 yrs:

                    0.018014     7.21    0.032964    13.19    0.050311  
 20.12 

Youth 13-19 yrs:

                    0.011055     4.42    0.018091     7.24    0.034181  
 13.67 

Adults 20-49 yrs:

                    0.010157     4.06    0.016999     6.80    0.025295  
 10.12 

Adults 50+ yrs:

                    0.010121     4.05    0.016060     6.42    0.024819  
  9.93 

Females 13-49 yrs:

                    0.010797     4.32    0.017317     6.93    0.034079  
 13.63 

Attachment 4.  Summary of the Results of the Chronic Dietary Exposure
Assessment of Clothianidin.

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for CLOTHIANIDIN                     (1994-98
data)

Residue file name: C:\Documents and Settings\mdoherty\My
Documents\Chemistry Reviews\!DEEM Runs\Clothianidin and
Thiamethoxam\2009\044309 (2009) Chronic.R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 07-29-2009/13:12:30     Residue file dated:
07-29-2009/13:09:54/8

Reference dose (RfD, Chronic) = .098 mg/kg bw/day

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.004582                
4.7%

U.S. Population (spring season)             0.004550                
4.6%

U.S. Population (summer season)             0.004459                
4.6%

U.S. Population (autumn season)             0.004678                
4.8%

U.S. Population (winter season)             0.004640                
4.7%

Northeast region                            0.004989                
5.1%

Midwest region                              0.004553                
4.6%

Southern region                             0.004141                
4.2%

Western region                              0.004949                
5.0%

Hispanics                                   0.004744                
4.8%

Non-hispanic whites                         0.004507                
4.6%

Non-hispanic blacks                         0.004502                
4.6%

Non-hisp/non-white/non-black                0.005657                
5.8%

All infants (< 1 year)                      0.012680               
12.9%

Nursing infants                             0.006768                
6.9%

Non-nursing infants                         0.014925               
15.2%

Children 1-6  yrs                           0.013620               
13.9%

Children 7-12 yrs                           0.005349                
5.5%

Females 13-19 (not preg or nursing)         0.003256                
3.3%

Females 20+ (not preg or nursing)           0.003404                
3.5%

Females 13-50 yrs                           0.003554                
3.6%

Females 13+ (preg/not nursing)              0.003802                
3.9%

Females 13+ (nursing)                       0.004185                
4.3%

Males 13-19 yrs                             0.003112                
3.2%

Males 20+ yrs                               0.003181                
3.2%

Seniors 55+                                 0.003451                
3.5%

萏֠萑褐葞֠葠褐摧䀓Ù

됂逃$愂Ĥ摧䀓Ù

ᐆ

ᐆ

ᐆ

ᐆ

ᐆ

ᐆ

 

#

)

-

N

V

W

a

c

j

s

t

~

…

‡

Ž

ä

æ

,

-

Y

d

g

i

{

}

 

-

M

N

t

‘

Ã

ã

ä

-

L

j

|

}

}

Ž

hs

hM

h@C

+

  h]L

 h]L

  h]L

h!

摧㇚¢©欀굤

摧㇚¢©欀ꍤ

&

¼

<

Œ

Ü

l

¼

Children 1-2 yrs                            0.018429               
18.8%

Children 3-5 yrs                            0.012188               
12.4%

Children 6-12 yrs                           0.005801                
5.9%

Youth 13-19 yrs                             0.003194                
3.3%

Adults 20-49 yrs                            0.003229                
3.3%

Adults 50+ yrs                              0.003438                
3.5%

Females 13-49 yrs                           0.003325                
3.4%

------------------------------------------------------------------------
-------

Clothianidin (044309)	Dietary Exposure and Risk Assessment	DP Number: 
D364363

 PAGE   

Page   PAGE  1  of   NUMPAGES  20 

DRAFT – Confidential, Internal, and Deliberative Material

[Chemical Name]	Dietary Exposure and Risk Assessment	DP Number:
[xxxxxxx]

PC Code:  [xxxxxx]