Document ID: EPA-HQ-OPP-2003-0043-0001
Agency: epa
Document Type: Notice
Title: Extension of an Experimental Use Permit
Posted Date: 2003-03-12T05:00Z

11855
Federal
Register
/
Vol.
68,
No.
48
/
Wednesday,
March
12,
2003
/
Notices
U.
S.
population
(%
of
RfD)
Non­
nursing
infants
(%
of
RfD)

SCI­
GROW
ground
water
estimation1
<
0.10
0.20
PRZM/
EXAMS
surface
water
estimation1
0.30
1.10
Total
of
RfD
used
by
diet
and
water
0.58
2.00
1Used
highest
values
predicted
from
the
model
for
all
agricultural
uses.
Assumes
2L/
day
and
70
kg
adult;
1L/
day
and
10
kg
infant.

2.
Non­
dietary
exposure.
For
nonoccupational
exposure,
dimethenamid/
dimethenamid­
P
is
not
registered
for
either
golf
course
or
homeowner
uses
which
could
contribute
to
``
non­
dietary
or
other
exposure.''

D.
Cumulative
Effects
BASF
has
considered
the
potential
for
cumulative
effects
of
dimethenamid
and
other
substances
that
have
a
common
mechanism
of
toxicity.
BASF
is
aware
of
several
other
chloroacetanilide
herbicides
that
have
been
considered
structurally
similar
to
dimethenamid,
these
being:
Acetochlor,
propachlor,
butachlor,
metolachlor,
and
alachlor.
However,
BASF
believes
that
consideration
of
a
common
mechanism
of
toxicity
to
these
products
is
not
appropriate
or
valid.
This
conclusion
was
based
on
the
presentation
EPA
made
to
the
EPA
FIFRA
Science
Advisory
Panel
(
SAP)
on
March
20,
1997.
The
title
of
the
presentation
was
``
Grouping
of
Chloroacetanilide
Pesticides
Based
on
a
Common
Mechanism
of
Toxicity.''
In
this
presentation
EPA
showed
the
structure
of
several
chloroacetanilides
that
included
dimethenamid.
BASF
is
identifying
Chlor
 
7
as
dimethenamid.
EPA
concluded
that
Chlor
 
7
should
not
be
considered
to
have
a
common
mechanism
to
the
other
chloroacetanilides
based
on
the
following
reasons:
 
Except
for
Chlor
 
7
all
other
members
of
this
case
study
have
a
potential
to
generate
a
quinone
imine.
The
quinone
imine
intermediate,
is
capable
of
reacting
with
macromolecules.
 
Chlor
 
7
has
not
produced
nasal
nor
thyroid
tumors
in
rats,
thus
does
not
support
inclusion
in
the
group
for
a
common
mechanism
for
these
tumor
types.
For
liver
tumors,
Chlor
 
1,
Chlor
 
7,
Chlo
 
r5,
and
Chlor
 
6,
can
be
potentially
grouped
for
a
common
mechanism,
but
EPA
determined
that
there
is
no
knowledge
of
a
common
mechanism
of
toxicity
or
of
a
common
toxic
species
responsible
for
the
effect.
Therefore,
EPA
concluded
that
because
a
mechanism
can
not
be
postulated,
it
believes
that
sufficient
evidence
is
not
available
to
support
a
common
mechanism
for
this
tumor
type
with
these
materials.
Therefore,
BASF
agrees
with
the
position
put
forward
by
the
Agency
and
confirmed
by
the
SAP
that
a
common
mechanism
is
inappropriate
for
dimethenamid
(
Chlor
 
7)
and
the
other
chloroacetanilides
mentioned
in
section
D.
BASF
has
considered
only
the
potential
risks
of
dimethenamid
in
its
exposure
assessment.

E.
Safety
Determination
1.
U.
S.
population.
Using
the
exposure
assumptions
described
in
section
C.,
based
on
the
completeness
and
the
reliability
of
the
toxicity
data,
BASF
has
estimated
that
aggregate
exposure
to
dimethenamid
will
utilize
<
1%
of
the
RfD
(
0.05
mg/
kg/
day)
for
the
U.
S.
population.
EPA
generally
has
no
concern
for
exposure
below
100%
of
the
RfD.
Therefore,
based
on
the
completeness
and
reliability
of
the
toxicity
data,
and
the
exposure
assessment
discussed
in
sections
B.
and
C.,
BASF
concludes
that
there
is
a
reasonable
certainty
that
no
harm
will
result
from
aggregate
exposure
to
residues
of
dimethenamid
including
all
anticipated
dietary
exposure
and
all
other
non­
occupational
exposures.
2.
Infants
and
children.
BASF
cites
results
of
developmental
toxicity
studies
reported
in
section
B.
3.
including:
 
Observed
developmental
toxicity
effects
in
rats
are
not
indicative
of
teratogenic
effect.
 
The
results
of
developmental
study
in
rabbits
also
demonstrated
that
dimethenamid
is
not
a
teratogenic
compound
and
has
a
development
toxicity
NOAEL
of
75
mg/
kg/
day
and
a
maternal
toxicity
of
37.5
mg/
kg/
day.
BASF
believes
that
these
test
results
demonstrate
that
the
rat
and
rabbit
are
similarly
sensitive
to
dimethenamid.
Additionally,
the
NOAEL
of
5
mg/
kg/
day
from
the
chronic
rat
study
used
to
set
the
RfD
is
7.5X
and
5X
lower
than
the
maternal
NOAELs
established
in
the
rabbit
and
rat
teratology
studies,
respectively.
The
developmental
effects
observed
in
either
the
rat
or
rabbit
occurred
only
at
maternally
toxic
doses.
Therefore,
BASF
concludes
that
no
additional
safety
factor
is
needed
for
children.
F.
International
Tolerances
A
maximum
residue
level
has
not
been
established
under
Codex
Alimentarius
Commission
for
dimethenamid
for
any
of
the
proposed
uses.

[
FR
Doc.
03
 
5914
Filed
3
 
11
 
03;
8:
45
am]

BILLING
CODE
6560
 
50
 
S
ENVIRONMENTAL
PROTECTION
AGENCY
[
OPP
 
2003
 
0043;
FRL
 
7292
 
5]

Extension
of
an
Experimental
Use
Permit
AGENCY:
Environmental
Protection
Agency
(
EPA).
ACTION:
Notice.

SUMMARY:
EPA
has
granted
an
extension
of
an
experimental
use
permit
(
EUP)
to
the
following
pesticide
applicant.
An
EUP
permits
use
of
a
pesticide
for
experimental
or
research
purposes
only
in
accordance
with
the
limitations
in
the
permit.

FOR
FURTHER
INFORMATION
CONTACT:
Ann
Sibold,
Registration
Division
(
7505C),
Office
of
Pesticide
Programs,
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460
 
0001;
telephone
number:
(
703)
305
 
6502;
e­
mail
address:
sibold.
ann@
epa.
gov.

SUPPLEMENTARY
INFORMATION:

I.
General
Information
A.
Does
this
Action
Apply
to
Me?

This
action
is
directed
to
the
public
in
general.
Although
this
action
may
be
of
particular
interest
to
those
persons
who
conduct
or
sponsor
research
on
pesticides,
the
Agency
has
not
attempted
to
describe
all
the
specific
entities
that
may
be
affected
by
this
action.
If
you
have
any
questions
regarding
the
information
in
this
action,
consult
the
person
listed
under
FOR
FURTHER
INFORMATION
CONTACT.

B.
How
Can
I
Get
Copies
Of
This
Document
and
Other
Related
Information?

1.
Docket.
EPA
has
established
an
official
public
docket
for
this
action
under
docket
identification
(
ID)
number
OPP
 
2003
 
0043.
The
official
public
docket
consists
of
the
documents
specifically
referenced
in
this
action,
any
public
comments
received,
and
other
information
related
to
this
action.
Although
a
part
of
the
official
docket,
the
public
docket
does
not
include
Confidential
Business
Information
(
CBI)
or
other
information
whose
disclosure
is
VerDate
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31>
2003
15:
39
Mar
11,
2003
Jkt
200001
PO
00000
Frm
00056
Fmt
4703
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4703
E:\
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FM\
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11856
Federal
Register
/
Vol.
68,
No.
48
/
Wednesday,
March
12,
2003
/
Notices
restricted
by
statute.
The
official
public
docket
is
the
collection
of
materials
that
is
available
for
public
viewing
at
the
Public
Information
and
Records
Integrity
Branch
(
PIRIB),
Rm.
119,
Crystal
Mall
#
2,
1921
Jefferson
Davis
Hwy.,
Arlington,
VA.
This
docket
facility
is
open
from
8:
30
a.
m.
to
4
p.
m.,
Monday
through
Friday,
excluding
legal
holidays.
The
docket
telephone
number
is
(
703)
305
 
5805.
2.
Electronic
access.
You
may
access
this
Federal
Register
document
electronically
through
the
EPA
Internet
under
the
``
Federal
Register''
listings
at
http://
www.
epa.
gov/
fedrgstr/.
An
electronic
version
of
the
public
docket
is
available
through
EPA's
electronic
public
docket
and
comment
system,
EPA
Dockets.
You
may
use
EPA
Dockets
at
http://
www.
epa.
gov/
edocket/
to
submit
or
view
public
comments,
access
the
index
listing
of
the
contents
of
the
official
public
docket,
and
to
access
those
documents
in
the
public
docket
that
are
available
electronically.
Although
not
all
docket
materials
may
be
available
electronically,
you
may
still
access
any
of
the
publicly
available
docket
materials
through
the
docket
facility
identified
in
Unit
I.
B.
1.
Once
in
the
system,
select
``
search,''
then
key
in
the
appropriate
docket
ID
number.

II.
EUP
EPA
has
extended
the
following
EUP:
241
 
EUP
 
141.
Extension.
BASF
Corporation,
26
Davis
Drive,
Research
Triangle
Park,
NC
27709
 
3528.
This
EUP
allows
the
use
of
289.27
pounds
of
the
termiticide
chlorfenapyr
not
to
exceed
22
acres
of
structures
to
evaluate
the
control
of
termites.
The
program
is
authorized
only
in
the
States
of
Alabama,
Arizona,
Arkansas,
California,
Connecticut,
Delaware,
District
of
Columbia,
Florida,
Georgia,
Hawaii,
Idaho,
Illinois,
Indiana,
Iowa,
Kentucky,
Louisiana,
Maryland,
Massachusetts,
Michigan,
Mississippi,
Missouri,
Nebraska,
New
Jersey,
New
York,
North
Carolina,
Ohio,
Oregon,
Pennsylvania,
Rhode
Island,
South
Carolina,
Tennessee,
Texas,
Virginia,
and
Washington.
The
EUP
extension
is
effective
from
January
1,
2003
to
December
31,
2004.

Authority:
7
U.
S.
C.
136c.

List
of
Subjects
Environmental
protection,
Experimental
use
permits.
Dated:
February
24,
2003.
Debra
Edwards,
Acting
Director,
Registration
Division,
Office
of
Pesticide
Programs.

[
FR
Doc.
03
 
5476
Filed
3
 
11
 
03;
8:
45
am]

BILLING
CODE
6560
 
50
 
S
ENVIRONMENTAL
PROTECTION
AGENCY
[
OPP
 
2003
 
0054;
FRL
 
7294
 
9]

Pesticides:
Procedures
Concerning
the
Development,
Modification,
and
Implementation
of
Policy
Guidance
Documents;
Notice
of
Availability
AGENCY:
Environmental
Protection
Agency
(
EPA).
ACTION:
Notice.

SUMMARY:
EPA
is
announcing
the
availability
for
comment
of
a
paper
discussing
procedural
guidance
for
policy
development
in
the
Office
of
Pesticide
Programs
(
OPP).
The
procedures
have
two
goals:
To
increase
public
participation
in
the
development,
modification
and
implementation
of
OPP
policy
guidance
documents;
and
to
clarify
that
while
such
documents
are
non­
binding
policy
statements
and
not
legally
binding
rules,
they
nonetheless
play
an
important
role
in
helping
to
ensure
a
consistent
starting
point
for
OPP
decision
making.
DATES:
Comments,
identified
by
docket
ID
number
OPP
 
2003
 
0054,
must
be
received
on
or
before
May
12,
2003.
ADDRESSES:
Comments
may
be
submitted
electronically,
by
mail,
or
through
hand
delivery/
courier.
Follow
the
detailed
instructions
as
provided
in
Unit
I.
of
the
SUPPLEMENTARY
INFORMATION.

FOR
FURTHER
INFORMATION
CONTACT:
William
L.
Jordan,
Senior
Policy
Adviser
(
7501C),
Office
of
Pesticide
Programs,
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460
 
0001;
telephone
number:
(
703)
305
 
1049;
fax
number:
(
703)
308
 
4776;
e­
mail
address:
jordan.
william@
epa.
gov.

SUPPLEMENTARY
INFORMATION:

I.
General
Information
A.
Does
this
Action
Apply
to
Me?

This
action
is
directed
to
the
public
in
general,
and
may
be
of
interest
to
a
wide
range
of
stakeholders,
including
environmental,
human
health,
and
agricultural
advocates;
the
chemical
industry;
pesticide
users;
and
members
of
the
public
interested
in
the
use
of
pesticides.
The
Agency
has
not
attempted
to
describe
all
the
persons
or
entities
who
may
be
interested
in
or
affected
by
this
action.
If
you
have
questions
in
this
regard,
consult
the
person
listed
under
FOR
FURTHER
INFORMATION
CONTACT.

B.
How
Can
I
Get
Copies
of
This
Document
and
Other
Related
Information?
1.
Docket.
EPA
has
established
an
official
public
docket
for
this
action
under
docket
identification
(
ID)
number
OPP
 
2003
 
0054.
The
official
public
docket
consists
of
the
documents
specifically
referenced
in
this
action,
any
public
comments
received,
and
other
information
related
to
this
action.
Although
a
part
of
the
official
docket,
the
public
docket
does
not
include
Confidential
Business
Information
(
CBI)
or
other
information
whose
disclosure
is
restricted
by
statute.
The
official
public
docket
is
the
collection
of
materials
that
is
available
for
public
viewing
at
the
Public
Information
and
Records
Integrity
Branch
(
PIRIB),
Rm.
119,
Crystal
Mall
#
2,
1921
Jefferson
Davis
Hwy.,
Arlington,
VA.
This
docket
facility
is
open
from
8:
30
a.
m.
to
4
p.
m.,
Monday
through
Friday,
excluding
legal
holidays.
The
docket
telephone
number
is
(
703)
305
 
5805.
2.
Electronic
access.
You
may
access
this
Federal
Register
document
electronically
through
the
EPA
Internet
under
the
``
Federal
Register''
listings
at
http://
www.
epa.
gov/
fedrgstr.
An
electronic
version
of
the
public
docket
is
available
through
EPA's
electronic
public
docket
and
comment
system,
EPA
Dockets.
You
may
use
EPA
Dockets
at
http://
www.
epa.
gov/
edocket/
to
submit
or
view
public
comments,
access
the
index
listing
of
the
contents
of
the
official
public
docket,
and
to
access
those
documents
in
the
public
docket
that
are
available
electronically.
Once
in
the
system,
select
``
search,''
then
key
in
the
appropriate
docket
ID
number.
Certain
types
of
information
will
not
be
placed
in
the
EPA
Dockets.
Information
claimed
as
CBI
and
other
information
whose
disclosure
is
restricted
by
statute,
which
is
not
included
in
the
official
public
docket,
will
not
be
available
for
public
viewing
in
EPA's
electronic
public
docket.
EPA's
policy
is
that
copyrighted
material
will
not
be
placed
in
EPA's
electronic
public
docket
but
will
be
available
only
in
printed,
paper
form
in
the
official
public
docket.
To
the
extent
feasible,
publicly
available
docket
materials
will
be
made
available
in
EPA's
electronic
public
docket.
When
a
document
is
selected
from
the
index
list
in
EPA
Dockets,
the
system
will
identify
whether
the
document
is
available
for
viewing
in
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31>
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2003
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