Document ID: EPA-HQ-OPP-2007-1151-0008
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2008-01-16T05:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

January 9, 2008

  SEQ CHAPTER \h \r 1 MEMORANDUM

SUBJECT:	Diiodomethyl p-tolyl sulfone– Incident Report Summary

PC Code: 	101002

DP Barcode: 	344852

	

FROM:	Jonathan Chen, Ph.D.	

	Senior Toxicologist, 

	Risk Assessment and Science Support Branch (RASSB)

Antimicrobial Division (7510P)

THROUGH:	Rick Petrie

Team Leader, Team Three

RASSB / AD

		

		And

Norm Cook

Chief

RASSB / AD

TO:	Avivah Jakob

	Team 36

	Regulatory Management Branch II / AD

Attached is RASSB’s incident report summary associated with
Diiodomethyl p-tolyl sulfone (Amical 48). 



INCIDENT REPORTS ASSOCIATED WITH

Diiodomethyl p-tolyl sulfone 

 (PC CODE: 101002)

January 9, 2008

U.S. Environmental Protection Agency

Office of Pesticide Programs

Antimicrobials Division

0.0	BACKGROUND tc \l1 "TABLE OF CONTENTS0.0	BACKGROUND	11.0	HAZARD
CHARACTERIZATION	22.0	AVAILABLE DATABASE	23.0	DATA GAP(S)	34.0	HAZARD
ASSESSMENT	44.1	Acute Toxicity	44.2	Subchronic Toxicity	44.3
Reproductive and Developmental Toxicity	64.4	Mutagenicity and
Carcinogenicity	74.7	Neurotoxicity	85.0	HAZARD ENDPOINT SELECTION	95.1
Acute Reference Dose (RfD) 	95.2	Chronic Dietary Reference Dose (RfD)
105.3	Occupational/Residential Exposure	105.3.1	Dermal Absorption
105.3.2	Short-Term Dermal - (1-7 Days)	115.3.3	Intermediate-Term Dermal
115.3.4	Long-Term Dermal	125.3.5	Inhalation Exposure 	125.3.6	MOEs	126.0
FQPA CONSIDERATIONS	147.0	REFERENCES	150.0	BACKGROUND 

Diiodomethyl p-tolyl sulfone is a fungicide, algaecide, bacteriostat,
insecticide, and/or miticide.  It is used in drains and/grease traps in
food handling/storage establishments premises and equipment.  It is used
as materials preservative in paints (in-can), coatings, fire retardant,
adhesives, caulks, sealants, slurries,
dispersions/emulsions/solutions/suspensions, rubber products,
plastic/pvc/vinyl products, hides/leathers/leather products, textiles,
papermaking, paper and paperboard, nitrocellulose, melamine formaldehyde
thermosetting resins. It is used in septic systems in industrial
processes and water systems.  Amical is also used as a general wood
preservative.  The purpose of this report is to review the evidence of
health effects in humans resulting from exposure to Amical 48. The
potential health effects of Amical 48  in humans, reported as incident
reports from different sources, are summarized

1.0 	INCIDENT REPORT DATA ASSOCIATED WITH HEALTH EFFECTS 

The following databases have been consulted for incident data:

OPP Incident Data System (IDS) - The Incident Data System of The Office
of Pesticide Programs (OPP) of the Environmental Protection Agency (EPA)
contains reports of incidents from various sources, including
registrants, other federal and state health and environmental agencies
and individual consumers, submitted to OPP since 1992.  Reports
submitted to the Incident Data System represent anecdotal reports or
allegations only, unless otherwise stated.  Typically no conclusions can
be drawn implicating the pesticide as a cause of any of the reported
health effects.  Nevertheless, sometimes with enough cases and/or enough
documentation risk mitigation measures may be suggested.

Poison Control Centers - as the result of a data purchase by EPA, OPP
received Poison Control Center data covering the years 1993 through 2003
for all pesticides.  Most of the national Poison Control Centers (PCCs)
participate in a national data collection system, the Toxic Exposure
Surveillance System, which obtains data from about 65-70 centers at
hospitals and universities.  PCCs provide telephone consultation for
individuals and health care providers on suspected poisonings involving
drugs, household products, pesticides, etc.

California Department of Pesticide Regulation - California has
collected uniform data on suspected pesticide poisonings since 1982. 
Physicians are required, by statute, to report to their local health
officer all occurrences of illness suspected of being related to
exposure to pesticides.  The majority of the incidents involve workers. 
Information on exposure (worker activity), type of illness (systemic,
eye, skin, eye/skin and respiratory), likelihood of a causal
relationship, and number of days off work and in the hospital are
provided.

National Pesticide Telecommunications Network (NPTN) - NPTN is a
toll-free information service supported by OPP.  A ranking of the top
200 active ingredients for which telephone calls were received during
calendar years 1984-1991, inclusive, has been prepared.  The total
number of calls was tabulated for the categories of human incidents,
animal incidents, calls for information, and others.

2.0	SUMMARY AND CONCLUSIONS

There are no Amical 48 specific incidences been reported in any of the
databases.

 PAGE   

Page   PAGE  4  of   NUMPAGES  4