Document ID: EPA-HQ-OPP-2009-0900-0004
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2010-03-31T04:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

 		     WASHINGTON, D.C. 20460

 ADVANCE \d61 	OFF		ICE OF PREVENTION,

OFFICE OF PESTICIDES AND TOXIC SUBSTANCES        

MEMORANDUM

DATE:		February 22, 2010

SUBJECT:	Registration Review:  Product Chemistry Data Review for the
Pesticide Menthol

Registration Review Case #:		4063

PC Codes:						051601  

CAS Numbers:					1490-04-6

Chemical Class:					Biochemical

FROM:		Jacob Moore, Chemist /s/ 02/22/10

Biochemical Pesticides Branch

Biopesticides & Pollution Prevention Division (7511P)

TO:			Colin Walsh, Regulatory Action Leader

Biochemical Pesticides Branch

Biopesticides & Pollution Prevention Division (7511P) 

ACTION REQUESTED

	A preliminary assessment of available information on product chemistry
data associated with the pesticide menthol and its biochemical products
in support of the development of a Registration Review Work Plan.

Introduction

	The EPA has made the determination that there is adequate information
available on menthol.  Menthol is currently registered as an active
ingredient in two products, summarized below:

Table 1.  Summary of products containing menthol as an active
ingredient.

Name	Registration Number	Concentration (w/w)	Use

Mite-A-Thol	61671-1	99.94%	Control of Tracheal Mite

API Life Var	73219-1	3.73%	Control of Varroa Mite

	Concerning the product chemistry of menthol much information has been
provided by registrants.  Also, as menthol has many commercial uses
outside of the realm of pesticides, a wealth of information is available
in the public literature.  Given this, a complete product chemistry data
set is available for menthol.  The Agency does not anticipate the need
for additional data at this point.

Table 2.  Menthol Chemical Identity

 

.

Product Chemistry Summary

	The Agency has conducted a review of the available product chemistry
data and information.  These data are summarized below.

Table 3.  Product Chemistry Data Requirements Summary

Guideline No.	Physical and Chemical Properties	Status1	Value

830.1100	Product Identity and Composition	A	Refer to Tables 1 & 2.

830.1200	Description of starting materials, production and formulation
process	A	CBI

830.1400	Discussion of formation of impurities	A	CBI

830.1700	Preliminary analysis	A	CBI 

830.6302	Color	A	Colorless or white

830.6303	Physical state		A	Crystals (solid)

830.6304	Odor	A	Peppermint

830.6313	Stability to normal and elevated temperatures, metals and metal
ions	A	Stable

830.7000	pH	N/A	Testing done on EP

830.7220	Melting point/melting range	A	41-44oC

	Boiling point/boiling range	A	212oC

830.7300	Density	A	0.890 at 30oC

830.7520	Particle size, fiber length, and diameter distribution	N/A

	830.7550

830.7560

830.7570	Partition coefficient (n-Octanol/Water)	N/A	Partially soluble
in water

830.7840	Water solubility 	A	Slightly soluble in water; very soluble in
alcohol, chloroform, and ether.

830.7950	Vapor pressure	A	0.8 mmHg at 20oC

A=Acceptable, N/A=Not Applicable, N/D=Not Determined

Sources

Report of the Food Quality Protection Act (FQPA) Tolerance Reassessment
Progress and Risk Management Decision (TRED) for Menthol.  September
2004.

EPA Memorandum from C. Swartz thru W. Hazel to K. Davis and F. Chow. 
October 26, 1992.

Menthol			Case #:  4063

051601