Document ID: EPA-HQ-OPP-2010-0588-0009
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2011-01-21T05:00Z

December 21, 2010

EXPLANATION OF FILE CONTENT

In support of the February 15-18, 2011, SAP meeting to consider the
report “Source-to-Outcome Modeling Physiologically-Based
Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model linked to a Dietary
Exposure Model: Chlorpyrifos as a Case Study”, several electronic
documents and modeling-related files are being made available to the SAP
panel members as well as the general public.  The contents of the files
are generally described as attachments “A” to “H” in the report,
and these files appear on this CD within a series of folders marked as
“Attachment A” to “Attachment H”.  A listing of folder contents
for each attachment appears below, along with any explanatory notes on
extra material available to SAP members. 

Attachment A: In vitro human metabolism summary (1 page) Note: Full copy
of draft manuscript for submission also being made available to panel
members in paper copy format. 

Attachment B: Philpott, P. (2009) "June 24-25, 2009 EPA Human Studies
Review Board Meeting Report." Memo and final report (40 pages).  

Attachment C: The LifeStage and Variation models: acslX programs and
associated m files.

Attachment D: Cleveland, C.B. (2010) "2010 Update of the Acute Dietary
Risk Assessment for Chlorpyrifos."  Dow AgroSciences Unpublished Report
101760 (140 pages).  

Attachment E: Copies of inputs files used in dietary models (CARES,
DEEM, LIFELINE).

Attachment F: Copies of input files for PBPK/PD model runs.

Attachment G: Marty, M.S. and Andrus, A.K. (2010) "Comparison of
Cholinesterase (ChE) Inhibition in Young Adult and Preweanling CD Rats
after Acute and Repeated Chlorpyrifos or Chlorpyrifos-oxon Exposures." 
Dow AgroSciences Unpublished Report 091107.  Public release summary (7
pages).

Attachment H: Reiss, R.; Neal, B.; Lamb, J. (2010) "Benchmark Dose
Modeling for Cholinesterase Inhibition from Exposure to Chlorpyrifos and
Chlorpyrifos-Oxon."  Dow AgroSciences Unpublished Report 0900956.000
B0T0 06010.  Public release summary (4 pages).