Document ID: EPA-HQ-OPP-2011-0449-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2012-05-02T04:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                         WASHINGTON, D.C. 20460      

                                                 	OFFICE OF CHEMICAL SAFETY AND
                                                                                               POLLUTION PREVENTION
                                                                              	

MEMORANDUM

Date:  		30-NOV-2011  

SUBJECT:	Acequinocyl.  Chronic Aggregate Dietary (Food + Drinking Water) Exposure and Risk Assessment for the Section 3 Registration Action Use on Succulent Soybean Vegetable; Succulent Shelled Beans; Cowpea Forage; Caneberry Subgroup 13-07A; Melon Subgroup 9A; Cucumber; Cherry; Low-Growing Berry Subgroup 13-07G; and Small Fruit Vine Climbing, Except Fuzzy Kiwifruit, Subgroup 13-07F.

PC Code:  006329
DP Barcode:  D389990
Decision No.:  448205
Registration No.:  66330-38
Petition No.:  1E7864
Regulatory Action:  Section 3
Risk Assessment Type:  Dietary
Case No.:  7621
TXR No.:  NA
CAS No.:  57960-19-7
MRID No.:  NA
40 CFR:  §180.599

FROM:	Sarah J. Levy, Chemist
      Risk Assessment Branch 1 (RAB1)/Health Effects Division (HED; 7509P)

THROUGH:	Doug Dotson, Ph.D., Chemist
            Amelia Acierto, Chemist
            Dietary Exposure Science Advisory Council (DESAC)/HED (7509P)

                  and

            George F. Kramer, Ph.D., Branch Senior Scientist
            RAB1/HED (7509P)
            
TO:		Sarah J. Levy, Chemist/Risk Assessor
		RAB1/HED (7509P)

            and

      Barbara Madden, RM 05
      Registration Division (RD; 7505P)
      
Executive Summary

A chronic aggregate dietary (food + drinking water) exposure and risk assessment was conducted using the Dietary Exposure Evaluation Model (DEEM-FCID[(TM)], Version 2.03) which uses food consumption data from the U.S. Department of Agriculture's Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998.  The analysis was performed to support a requested Section 3 registration use of the miticide acequinocyl (2-(acetyloxy)-3-dodecyl-1,4-naphthalenedione) on the following crops:  succulent soybean vegetable; succulent shelled  beans; cowpea forage; caneberry subgroup 13-07A; melon subgroup 9A; cucumber; cherry; low-growing berry subgroup 13-07G; and small fruit vine climbing, except fuzzy kiwifruit, subgroup 13-07F.  An acute dietary assessment was not conducted for acequinocyl because an endpoint of concern attributable to a single dose was not identified; therefore, an aRfD was not established.  A cancer dietary assessment was not conducted because acequinocyl was classified as not likely to be carcinogenic to humans.
   
Chronic Dietary (Food + Drinking Water) Exposure Results and Characterization

Tolerance-level residues and 100 percent crop treated (%CT) data were used in the chronic dietary assessment.  DEEM ver. 7.81 default processing factors were used with the exception of those for grape juice and raisins (see "Residue Information" Section of this document for details).  For the chronic dietary assessment, the general U.S. population and all population subgroups have risk estimates that are not of concern to HED.  The chronic dietary risk estimate for the U.S. population is 13% of the chronic population-adjusted dose (cPAD).  The highest exposed population subgroup (children 1-2 years old) occupies 55% of the cPAD.  The use of anticipated residues (ARs), empirical processing factors, and %CT would refine further HED's exposure and risk estimates; however, refinement is not needed at this time.

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the population-adjusted dose (PAD).  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  HED is generally concerned when estimated cancer risk exceeds one in one million.  References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  "Available Information on Assessing Exposure from Pesticides, A User's Guide," 21-JUN-2000, web link:  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for acequinocyl was conducted by Sarah Levy (25-AUG-2010; D369101).

II.	Residue Information

Under PP1E7864, the Interregional Research Project No.4 (IR-4), on behalf of the Agricultural Experiment Station of TX, CA, OR, PA, GA, NM, OK, TN, UT, MI, FL, and AZ, is requesting the establishment of tolerances for combined residues of the insecticide acequinocyl, and its metabolite, 2-dodecyl-3-hydroxy-1,4-naphthoquinone (acequinocyl-OH), expressed as acequinocyl equivalents in/on the following commodities:  succulent soybean vegetable; succulent shelled beans; cowpea forage; caneberry subgroup 13-07A; melon subgroup 9A; cucumber; cherry; low-growing berry subgroup 13-07G; and small fruit vine climbing, except fuzzy kiwifruit, subgroup 13-07F.  No new data were submitted to support tolerances on succulent soybean vegetables, low growing berry 13-07G crop subgroup, or small fruit vine climbing subgroup 13-07F, except fuzzy kiwifruit.  The petitioner has requested that existing tolerances be expanded to these respective crops or crop groups.

Permanent tolerances are currently established under 40 CFR §180.599(a) for the combined residues of acequinocyl and its metabolite, acequinocyl-OH, expressed as acequinocyl equivalents, in/on a number of plant and livestock commodities.  Tolerances for plant commodities range from 0.02 ppm (tree nuts and pistachios) to 30 ppm (citrus oil), and tolerances for livestock commodities are established at 0.02 ppm in the fat and liver of cattle, goat, horse, and sheep.

Based on the structural similarity of acequinocyl-OH to parent and the presence of acequinocyl-OH at quantifiable levels in crops, the HED Metabolism Assessment Review Committee (MARC) concluded that parent and acequinocyl-OH are the residues of concern for risk assessment and tolerance expression in apples, oranges, and eggplant commodities (Memo, S. Levy, 07-JAN-2004; D297872).  For purposes of this petition, HED will allow translation of these results to caneberries, cantaloupe, cherry, and cucumber as these are fruit crops.  In addition, HED is willing to translate the results to succulent shelled beans because beans are low-consumption food items.  However, if in the future the petitioner requests new uses where apple, orange, and eggplant metabolism data cannot be translated, HED may ask for additional plant metabolism data.

The qualitative nature of acequinocyl residues in ruminants is understood based on an adequate goat metabolism study (Memo, S. Levy, 10-MAR-2004; D284757).  The metabolism of acequinocyl in goats appears to involve the loss of the acetyloxyl moiety to form acequinocyl-OH and partial cleavage of the dodecyl side chain to form AKM-15.  Opening and degradation of the quinone ring was also evidenced by the presence of AKM-18 and phthalic acid.  The MARC concluded that for tolerance expression, the residues of concern in livestock commodities include parent and acequinocyl-OH.  For risk assessment purposes, the residues of concern in livestock commodities are parent and acequinocyl-OH (for liver and kidney, metabolite AKM-15 is to be included as well (Memo, S. Levy, et al., 07-JAN-2004; D297872)). 

Metabolism data on poultry are not required at the present time as none of the proposed or existing uses of acequinocyl are on crops having regulated poultry feedstuffs.

Table 1.  Residues of Concern in Crops, Ruminants, and Drinking Water.
Matrix
Tolerance Expression
Residues for Risk Assessment
Fruit Crops
Acequinocyl + Acequinocyl-OH (R1)
Acequinocyl + Acequinocyl-OH (R1)
Ruminants
Acequinocyl + Acequinocyl-OH (R1)
Acequinocyl + Acequinocyl-OH (R1).  In liver and kidney, also include AKM-15.
Rotational Crops
Not Determined*
Not Determined*
Drinking Water
NA**
Acequinocyl + Acequinocyl-OH (R1)
* A confined rotational crop study has been reviewed and a 30-day plant-back interval has been recommended (Memo, S. Levy, 25-JUN-2008; DP# 351336).
** NA = not applicable.

Residue Data used for the Chronic Assessment:

Tolerance-level residues and 100%CT data were used in the chronic dietary assessment.  DEEM ver. 7.81 default processing factors were used with the exception of those for grape juice and raisins.  As residues were reduced in both grape juice (<0.02x) and raisin (0.15x), separate tolerances are not required for these commodities.  The DEEM ver. 7.81 default processing factors for juice and raisin were set to 1 as concentration was shown not to occur (Memo, S. Levy, 05-SEP-2007; D342805).

As cowpea forage and hay are significant feedstuff for livestock (dairy cattle only), the maximum reasonable balanced diet (MRBD) for acequinocyl was recalculated for this petition using the Agency's most recent guidance on constructing reasonably balanced livestock diets (Science Advisory Council for Chemistry (ChemSAC) memo, 30-JUN-2008).  The beef cattle MRBDs did not need to be recalculated as cowpea forage and hay are not beef feed items.  The feeding study data indicate that the currently established tolerance level of 0.02 ppm for residues in cattle, goat, horse, and sheep fat is appropriate.  Furthermore, the 0.02-ppm residue level is sufficient to cover residues of the additional metabolite (AKM-15) of concern in ruminant liver and kidney.  The established 0.02-ppm residue level in cattle, goat, horse, and sheep liver are appropriate; however, the commodity definition should be changed to "meat byproducts" rather than "liver."  With the establishment of the cattle, goat, horse, and sheep tolerance in meat byproducts, RD should remove the tolerance for liver.  See Table 2 for a summary of the data used in the chronic assessment.

Table 2.  Data and Residue Estimates Used in the Acequinocyl Chronic Dietary Analyses.
Commodity
                                  Data Source
                                    (MRID)
                                      %CT
                              Processing Factors
                        HED-Recommended Tolerance (ppm)
Bean, succulent shelled[1]
                                   48462901
                                       
                                       
                                      100
                                      NA
                                     0.30
Caneberry subgroup 13-07A
                                   48462902
                                       
                                      NA
                                      4.0
Melon subgroup 9A
                                   48462903
                                       
                                      NA
                                     0.15
Cucumber
                                   48462905
                                       
                                      NA
                                     0.15
Cherry, sweet
                                   48462904
                                       
                                      NA
                                     0.50
Cherry, tart[2]
                                       
                                       
                                      NA
                                      1.0
Soybean, vegetable, succulent
           Translated from established edible-podded bean tolerance
                                       
                                      NA
                                     0.25
Low growing berry subgroup13-07G[3]
               Translated from established strawberry tolerance
                                       
                                      NA
                                     0.50
Small fruit vine climbing subgroup 13-07F, except fuzzy kiwifruit
                  Translated from established grape tolerance
                                       
                                      NA
                                      1.6
Meat byproducts of cattle, goat, horse, and sheep
                              Extended from liver
                                       
                                      NA
                                     0.02
[1]   HED is recommending for cowpea forage and cowpea hay tolerances of 6.0 ppm and 18 ppm, respectively, however, these are feed items and are not in DEEM-FCID[(TM)].
[2]   The value for cherry, tart was used as the input in DEEM-FCID(TM) as the HED-recommended tolerance value was higher than the value for cherry, sweet.
[3]   The established strawberry tolerance is 0.40 ppm; however, for purposes of harmonization with Canada, HED is recommending to increase the tolerance to 0.50 ppm for this crop subgroup.

III.	Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED) (M. Lowit, 07-SEP-2011; D389520) and incorporated directly into this dietary assessment.  Water residues were incorporated directly into DEEM-FCID(TM) under the food categories "water, direct, all sources" and "water, indirect, all sources."

Acequinocyl can reach surface water via spray drift and less likely via runoff.  Due to its high Kd values it is expected to exhibit low mobility in soil and low potential to leach into groundwater. Once acequinocyl has entered surface water, it is not likely to persist as it will hydrolyze to form hydroxy-acequinocyl (also known as R-1).

There are no drinking water monitoring data available for acequinocyl or its metabolite acequinocyl-OH (R1), the residues of concern.  Groundwater estimated drinking water concentrations (EDWCs) were generated for acequinocyl using the Screening Concentration in Ground Water (SCI-GROW) Model.  Surface water EDWCs were generated using the Pesticide Root Zone Model/Exposure Analysis Modeling System (PRZM/EXAMS) model for all proposed uses except cranberry (cranberries are part of the low growing berries subgroup, 13-07G).  Cranberry harvesting may involve field flooding and PRZM/EXAMS is not currently parameterized to assess this type of scenario; therefore, cranberry was assessed using the provisional cranberry model (note that since the provisional cranberry model only uses a one year simulation, the highest 30-year annual average concentration is not available for the cranberry scenario).

Similar to previous drinking water assessments provided by EFED, two approaches were used in performing the drinking water assessment for proposed acequinocyl uses.  In Approach #1, acequinocyl was conservatively assumed to be stable to all routes of degradation to account for the uncertainties associated with the environmental fate data.  In Approach #2, total (acequinocyl + acequinocyl-OH) residues were modeled with the assumption that the half-lives of acequinocyl and R1 are valid and the total toxic residues were modeled to address toxicity concerns with R1.  The EDWCs are summarized below in Table 3.  Surface water EDWCs for the proposed uses are higher than those previously reported for both approaches.  The ground water EDWC for the current assessment is the same as the last assessment.

Table 3.  Recommended EDWCs of Acequinocyl Derived from the Previous Uses.
                         Drinking water source (model)
                           Proposed Use/Scenario[3]
                  EDWCs from Surface Water Sources (ug/L) 1,2

                                  Approach 1
                      (assume no acequinocyl degradation)
                                  Approach 2
                         (combined acequinocyl and R1)

                              1-in-10 year acute
                             1-in-10 year chronic
                                 30-year mean
                              1-in-10 year acute
                             1-in-10 year chronic
                                 30-year mean
Surface water
(PRZM/EXAMS)
Cherry/MI cherry
                                6.69 (25.89)[4]
                                     6.69 
                                  (17.84)[4]
                                6.69 (10.19)[4]
                                     5.59
                                     0.42
                                     0.26
Surface water
(PRZM/EXAMS)
Small fruit (vine climbing, except fuzzy kiwifruit, 13-07F)/NY grape
                                6.69 (23.12)[4]
                                     6.69 
                                  (15.34)[4]
                                     6.69 
                                   (9.57)[4]
                                     4.22
                                     0.38
                                     0.27
Surface water
(Provisional Cranberry Model)
Cranberry/Provisional Cranberry Model
                                     4.24
                                     3.75
                                      --
                                    3.81[5]
                                    1.36[5]
                                      --
Groundwater (SCIGROW)
All proposed uses
                                 3.6 x 10[-3]
                               <3.6 x 10[-3]
                               <3.6 x 10[-3]
                                 3.6 x 10[-3]
                               <3.6 x 10[-3]
                               <3.6 x 10[-3]
[1]   Bolded values are the recommended EDWCs by EFED.
[2]   A default PCA of 0.87 was applied.
[3]   Maximum of 2 applications of 0.3 lb ai/A for all proposed uses.
[4]   EDWC (shown in parentheses) exceeds the solubility limit of acequinocyl (6.69 ug/L at 20°C); therefore, the recommended EDWC is 6.69 ppb.  
[5]   Based on a one-year simulation; 1-10 year calculation is not applicable.

Since the surface water EDWCs are higher than the groundwater EDWC, HED selected the surface water value for use in the chronic dietary assessment.  The EDWC derived via Approach #1 represents the upper-bound value (6.69 ppb) while that derived via Approach #2 represents the lower-bound value (1.36 ppb).  The 6.69 ppb value was used in this dietary assessment as this value assures a conservative assessment.

IV.	DEEM-FCID[(TM)] Program and Consumption Information

An acequinocyl chronic dietary exposure assessment was conducted using DEEM-FCID[(TM)], Version 2.03 which incorporates consumption data from USDA's CSFII, 1994-1996 and 1998.  The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods "as consumed" (e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events.  Based on analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate.  The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

V.	Toxicological Information

On 14-OCT-2003, the HED Hazard Identification Assessment Review Committee (HIARC) reviewed the recommendations of the toxicology reviewer for acequinocyl with regard to the acute and chronic RfDs and the toxicological endpoint selection for use as appropriate in occupational/residential exposure risk assessments.  The potential for increased susceptibility of infants and children from exposure to acequinocyl was also evaluated as required by the Food Quality Protection Act (FQPA) of 1996 under the 2002 OPP 10X Guidance.  Table 4 is a summary of the toxicology doses and endpoints selected that are relevant to dietary exposure assessment (13-NOV-2003; TXR# 0052234).  The acequinocyl risk assessment team confirmed that the endpoints selected previously remain appropriate.

Table 4.  Summary of Toxicological Doses and Endpoints for Acequinocyl for Use in Dietary Exposure Risk Assessment.[1]
Exposure/
Scenario
Point of Departure
Uncertainty/
FQPA Safety Factors
RfD, PAD, Level of Concern 
Study and Toxicological Effects
Acute Dietary (General Population, including Infants and Children)
N/A
N/A
N/A
An endpoint of concern (effect) attributable to a single dose was not identified in the database.  Quantification of acute risk to general population including infants and children is not required.
Chronic Dietary 
(All Populations)
NOAEL= 2.7 mg/kg/day
UFA= 10x
UFH=10x
FQPA SF= 1x

cPAD = cRfD = 0.027 mg/kg/day 

18-month carcinogenicity study in mice;
LOAEL=7.0 mg/kg/day based on clinical chemistry and microscopic nonneoplastic lesions (brown pigmented cells and perivascular inflammatory cells in liver)
Cancer (oral, dermal, inhalation)   
Classification:  "Not likely to be Carcinogenic to Humans."
    [1]  UF = uncertainty factor, UFA = extrapolation from animal to human (interspecies), UFH = potential variation in sensitivity among members of the human population (intraspecies), FQPA SF = FQPA Safety Factor, NOAEL = no-observed adverse-effect level, LOAEL = lowest-observed adverse-effect level, RfD = reference dose (a = acute, c = chronic), PAD = population-adjusted dose, N/A = Not Applicable.  
    
VI.	Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID[(TM)] analyses estimate the dietary exposure of the U.S. population and various population subgroups.  The results reported in Table 5 are for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years.  An acute dietary assessment was not conducted for acequinocyl because an endpoint of concern attributable to a single dose was not identified; therefore, an aRfD was not established.  A cancer dietary assessment was not conducted because acequinocyl was classified as not likely to be carcinogenic to humans.
 
The chronic dietary exposure assessment (using tolerance level residues and 100% CT information for all registered and proposed uses) was conducted for the general U.S. population and various population subgroups.  Drinking water was incorporated directly into the dietary assessment using the chronic concentration for ground water generated by the PRZM/EXAMS model.  This assessment concludes that the chronic dietary risk estimates are not of concern to HED for the general U.S. population (13% cPAD) and all population subgroups.  The most highly exposed population subgroup is children 1-2 years old at 55% of the cPAD.
 
 Table 5.  Summary of Dietary (Food + Drinking Water) Exposure and Risk for Acequinocyl.
 Population Subgroup
                               Chronic Dietary[1]
 
                                Dietary Exposure
                                  (mg/kg/day)
                                     % cPAD
 U.S. Population (total)
                                    0.003627
                                       13
 All Infants (<1 year old)
                                    0.006513
                                       24
 Children 1-2 years old
                                    0.014761
                                       55
 Children 3-5 years old
                                    0.010370
                                       38
 Children 6-12 years old
                                    0.005172
                                       19
 Youth 13-19 years old
                                    0.002825
                                       11
 Adults 20-49 years old
                                    0.002525
                                      9.4
 Adults 50+ years old
                                    0.002473
                                      9.2
 Females 13-49 years old
                                    0.002563
                                      9.5
 [1] Chronic dietary endpoint of 0.027 mg/kg/day applies to the general U.S. population and all population subgroups.  The values for the highest exposed population are bolded.
 
 
 VII.		Characterization of Inputs/Outputs
 
The chronic analysis assumed tolerance-level residues and 100%CT data.  DEEM ver. 7.81 default processing factors were used with the exception of those for grape juice and raisins.  This analysis is considered very conservative and could be refined through the use of ARs for all commodities, %CT data for registered commodities, and/or additional empirical processing factors.

 VIII.		Conclusions
 
A chronic dietary exposure and risk assessment was conducted for the proposed food uses and permanent tolerances of acequinocyl, including potential exposure from drinking water.  

The chronic dietary (food + drinking water) exposure to acequinocyl is below HED's level of concern for the general U.S. population and all population subgroups.  The chronic dietary risk utilized 13% cPAD for the general U.S. population and 55% of the cPAD for children 1-2 years old, the most highly exposed population subgroup.  An acute dietary assessment was not conducted for acequinocyl because an endpoint of concern attributable to a single dose was not identified; therefore, an aRfD was not established.  A cancer dietary assessment was not conducted because acequinocyl was classified as not likely to be carcinogenic to humans.
 
 
 IX.		List of Attachments
 
 Attachment 1:  Chronic Food + Drinking Water Residue Input File.
 Attachment 2:  Chronic Results File.

 

cc:  M. Lowit (EFED/ERB1; 7507P)
RDI: DESAC (09-NOV-2011); G.F. Kramer (09-NOV-2011)
S. Levy:S10953:PY1:(703)305-0783:7590P
        Attachment 1:  Chronic Food + Drinking Water Residue Input File.

Filename: C:\Documents and Settings\slevy\Desktop\006329c_SL.R98
Chemical: Acequinocyl
RfD(Chronic): .027 mg/kg bw/day  NOEL(Chronic): 2.7 mg/kg bw/day
RfD(Acute): 0 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day
Date created/last modified: 11-16-2011/08:07:44/8          Program ver. 2.03
Comment: No acute dietary endpoint; not carcinogen.  cRfD=cPAD
--------------------------------------------------------------------------------
  EPA    Crop                                   Def Res     Adj.Factors   Comment
  Code    Grp  Commodity Name                    (ppm)       #1    #2   
-------- ---- -------------------------------  ----------  ------ ------  -------
06003470 6    Soybean, seed                      0.250000   1.000  1.000  1E7864
06010430 6A   Bean, snap, succulent              0.250000   1.000  1.000  9E7598
06010431 6A   Bean, snap, succulent-babyfood     0.250000   1.000  1.000  9E7598
06020310 6B   Bean, broad, succulent             0.250000   1.000  1.000  1E7864
06020330 6B   Bean, cowpea, succulent            0.250000   1.000  1.000  1E7864
06020370 6B   Bean, lima, succulent              0.250000   1.000  1.000  1E7864
08001480 8    Eggplant                           0.700000   1.000  1.000  9E7598
08002340 8    Okra                               0.700000   1.000  1.000  9E7598
08002700 8    Pepper, bell                       0.700000   1.000  1.000  9E7598
08002701 8    Pepper, bell-babyfood              0.700000   1.000  1.000  9E7598
08002710 8    Pepper, bell, dried                0.700000   1.000  1.000  9E7598
08002711 8    Pepper, bell, dried-babyfood       0.700000   1.000  1.000  9E7598
08002720 8    Pepper, nonbell                    0.700000   1.000  1.000  9E7598
08002721 8    Pepper, nonbell-babyfood           0.700000   1.000  1.000  9E7598
08002730 8    Pepper, nonbell, dried             0.700000   1.000  1.000  9E7598
08003740 8    Tomatillo                          0.700000   1.000  1.000  9E7598
08003750 8    Tomato                             0.700000   1.000  1.000  9E7598
08003751 8    Tomato-babyfood                    0.700000   1.000  1.000  9E7598
08003760 8    Tomato, paste                      0.700000   5.400  1.000  9E7598
08003761 8    Tomato, paste-babyfood             0.700000   5.400  1.000  9E7598
08003770 8    Tomato, puree                      0.700000   3.300  1.000  9E7598
08003771 8    Tomato, puree-babyfood             0.700000   3.300  1.000  9E7598
08003780 8    Tomato, dried                      0.700000  14.300  1.000  9E7598
08003781 8    Tomato, dried-babyfood             0.700000  14.300  1.000  9E7598
08003790 8    Tomato, juice                      0.700000   1.500  1.000  9E7598
09010750 9A   Cantaloupe                         0.150000   1.000  1.000  1E7864
09010800 9A   Casaba                             0.150000   1.000  1.000  1E7864
09011870 9A   Honeydew melon                     0.150000   1.000  1.000  1E7864
09013990 9A   Watermelon                         0.150000   1.000  1.000  1E7864
09014000 9A   Watermelon, juice                  0.150000   1.000  1.000  1E7864
09021350 9B   Cucumber                           0.150000   1.000  1.000  1E7864
10001060 10   Citrus citron                      0.200000   1.000  1.000  
10001070 10   Citrus hybrids                     0.200000   1.000  1.000  
10001080 10   Citrus, oil                       30.000000   1.000  1.000  
10001800 10   Grapefruit                         0.200000   1.000  1.000  
10001810 10   Grapefruit, juice                  0.200000   2.100  1.000  
10001970 10   Kumquat                            0.200000   1.000  1.000  
10001990 10   Lemon                              0.200000   1.000  1.000  
10002000 10   Lemon, juice                       0.200000   2.000  1.000  
10002001 10   Lemon, juice-babyfood              0.200000   2.000  1.000  
10002010 10   Lemon, peel                        0.200000   1.000  1.000  
10002060 10   Lime                               0.200000   1.000  1.000  
10002070 10   Lime, juice                        0.200000   2.000  1.000  
10002071 10   Lime, juice-babyfood               0.200000   2.000  1.000  
10002400 10   Orange                             0.200000   1.000  1.000  
10002410 10   Orange, juice                      0.200000   1.800  1.000  
10002411 10   Orange, juice-babyfood             0.200000   1.800  1.000  
10002420 10   Orange, peel                       0.200000   1.000  1.000  
10003070 10   Pummelo                            0.200000   1.000  1.000  
10003690 10   Tangerine                          0.200000   1.000  1.000  
10003700 10   Tangerine, juice                   0.200000   2.300  1.000  
11000070 11   Apple, fruit with peel             0.400000   1.000  1.000  
11000080 11   Apple, peeled fruit                0.400000   1.000  1.000  
11000081 11   Apple, peeled fruit-babyfood       0.400000   1.000  1.000  
11000090 11   Apple, dried                       0.400000   8.000  1.000  
11000091 11   Apple, dried-babyfood              0.400000   8.000  1.000  
11000100 11   Apple, juice                       0.400000   1.300  1.000  
11000101 11   Apple, juice-babyfood              0.400000   1.300  1.000  
11000110 11   Apple, sauce                       0.400000   1.000  1.000  
11000111 11   Apple, sauce-babyfood              0.400000   1.000  1.000  
11001290 11   Crabapple                          0.400000   1.000  1.000  
11002100 11   Loquat                             0.400000   1.000  1.000  
11002660 11   Pear                               0.400000   1.000  1.000  
11002661 11   Pear-babyfood                      0.400000   1.000  1.000  
11002670 11   Pear, dried                        0.400000   6.250  1.000  
11002680 11   Pear, juice                        0.400000   1.000  1.000  
11002681 11   Pear, juice-babyfood               0.400000   1.000  1.000  
11003100 11   Quince                             0.400000   1.000  1.000  
12000900 12   Cherry                             1.000000   1.000  1.000  1E7864
12000901 12   Cherry-babyfood                    1.000000   1.000  1.000  1E7864
12000910 12   Cherry, juice                      1.000000   1.500  1.000  1E7864
12000911 12   Cherry, juice-babyfood             1.000000   1.500  1.000  1E7864
13010550 13A  Blackberry                         4.000000   1.000  1.000  1E7864
13010560 13A  Blackberry, juice                  4.000000   1.000  1.000  1E7864
13010561 13A  Blackberry, juice-babyfood         4.000000   1.000  1.000  1E7864
13010580 13A  Boysenberry                        4.000000   1.000  1.000  1E7864
13011420 13A  Dewberry                           4.000000   1.000  1.000  1E7864
13012080 13A  Loganberry                         4.000000   1.000  1.000  1E7864
13013200 13A  Raspberry                          4.000000   1.000  1.000  1E7864
13013201 13A  Raspberry-babyfood                 4.000000   1.000  1.000  1E7864
13013210 13A  Raspberry, juice                   4.000000   1.000  1.000  1E7864
13013211 13A  Raspberry, juice-babyfood          4.000000   1.000  1.000  1E7864
13020570 13B  Blueberry                          0.500000   1.000  1.000  
13020571 13B  Blueberry-babyfood                 0.500000   1.000  1.000  
14000030 14   Almond                             0.020000   1.000  1.000  
14000031 14   Almond-babyfood                    0.020000   1.000  1.000  
14000040 14   Almond, oil                        0.020000   1.000  1.000  
14000041 14   Almond, oil-babyfood               0.020000   1.000  1.000  
14000590 14   Brazil nut                         0.020000   1.000  1.000  
14000680 14   Butternut                          0.020000   1.000  1.000  
14000810 14   Cashew                             0.020000   1.000  1.000  
14000920 14   Chestnut                           0.020000   1.000  1.000  
14001550 14   Filbert                            0.020000   1.000  1.000  
14001560 14   Filbert, oil                       0.020000   1.000  1.000  
14001850 14   Hickory nut                        0.020000   1.000  1.000  
14002130 14   Macadamia nut                      0.020000   1.000  1.000  
14002690 14   Pecan                              0.020000   1.000  1.000  
14002820 14   Pistachio                          0.020000   1.000  1.000  
14003910 14   Walnut                             0.020000   1.000  1.000  
21000460 M    Beef, meat byproducts              0.020000   1.000  1.000  
21000461 M    Beef, meat byproducts-babyfood     0.020000   1.000  1.000  
21000470 M    Beef, fat                          0.020000   1.000  1.000  
21000471 M    Beef,fat-babyfood                  0.020000   1.000  1.000  
21000480 M    Beef, kidney                       0.020000   1.000  1.000  
21000490 M    Beef, liver                        0.020000   1.000  1.000  
21000491 M    Beef, liver-babyfood               0.020000   1.000  1.000  
23001710 M    Goat, fat                          0.020000   1.000  1.000  
23001720 M    Goat, kidney                       0.020000   1.000  1.000  
23001730 M    Goat, liver                        0.020000   1.000  1.000  
26003400 M    Sheep, meat byproducts             0.020000   1.000  1.000  
26003410 M    Sheep, fat                         0.020000   1.000  1.000  
26003411 M    Sheep, fat-babyfood                0.020000   1.000  1.000  
26003420 M    Sheep, kidney                      0.020000   1.000  1.000  
26003430 M    Sheep, liver                       0.020000   1.000  1.000  
86010000 O    Water, direct, all sources         0.006690   1.000  1.000  1E7864
86020000 O    Water, indirect, all sources       0.006690   1.000  1.000  1E7864
95001300 O    Cranberry                          0.500000   1.000  1.000  1E7864
95001301 O    Cranberry-babyfood                 0.500000   1.000  1.000  1E7864
95001310 O    Cranberry, dried                   0.500000   1.000  1.000  1E7864
95001320 O    Cranberry, juice                   0.500000   1.100  1.000  1E7864
95001321 O    Cranberry, juice-babyfood          0.500000   1.100  1.000  1E7864
95001750 O    Grape                              1.600000   1.000  1.000  
95001760 O    Grape, juice                       1.600000   1.000  1.000  
95001761 O    Grape, juice-babyfood              1.600000   1.000  1.000  
95001770 O    Grape, leaves                      1.600000   1.000  1.000  
95001780 O    Grape, raisin                      1.600000   1.000  1.000  
95001790 O    Grape, wine and sherry             1.600000   1.000  1.000  
95001880 O    Hop                                4.000000   1.000  1.000  9E7598
95001950 O    Kiwifruit                          1.600000   1.000  1.000  1E7864
95003590 O    Strawberry                         0.500000   1.000  1.000  1E7864
95003591 O    Strawberry-babyfood                0.500000   1.000  1.000  1E7864
95003600 O    Strawberry, juice                  0.500000   1.000  1.000  1E7864
95003601 O    Strawberry, juice-babyfood         0.500000   1.000  1.000  1E7864

                     Attachment 2:  Chronic Results File.
                                       
U.S. Environmental Protection Agency                             Ver. 2.00
DEEM-FCID Chronic analysis for ACEQUINOCYL                  (1994-98 data)
Residue file name: C:\Documents and Settings\slevy\Desktop\006329c_SL.R98
                                                Adjustment factor #2 used.
Analysis Date 11-16-2011/09:05:55 esidue file dated: 11-16-2011/08:07:44/8
Reference dose (RfD, Chronic) = .027 mg/kg bw/day
COMMENT 1: No acute dietary endpoint; not carcinogen.  cRfD=cPAD
==========================================================================
                    Total exposure by population subgroup
--------------------------------------------------------------------------
                                                    Total Exposure
                                      -----------------------------------
          Population                         mg/kg             Percent of   
           Subgroup                       body wt/day             Rfd       
-----------------------------------   -------------       ---------------
U.S. Population (total)                     0.003627                13.4%
U.S. Population (spring season)             0.003565                13.2%
U.S. Population (summer season)             0.003721                13.8%
U.S. Population (autumn season)             0.003572                13.2%
U.S. Population (winter season)             0.003653                13.5%
Northeast region                            0.004098                15.2%
Midwest region                              0.003612                13.4%
Southern region                             0.003232                12.0%
Western region                              0.003850                14.3%
Hispanics                                   0.003984                14.8%
Non-hispanic whites                         0.003597                13.3%
Non-hispanic blacks                         0.003467                12.8%
Non-hisp/non-white/non-black                0.003724                13.8%
All infants (< 1 year)                      0.006513                24.1%
Nursing infants                             0.003204                11.9%
Non-nursing infants                         0.007769                28.8%
Children 1-6  yrs                           0.011306                41.9%
Children 7-12 yrs                           0.004806                17.8%
Females 13-19 (not preg or nursing)         0.002860                10.6%
Females 20+ (not preg or nursing)           0.002497                 9.2%
Females 13-50 yrs                           0.002791                10.3%
Females 13+ (preg/not nursing)              0.002783                10.3%
Females 13+ (nursing)                       0.002812                10.4%
Males 13-19 yrs                             0.002783                10.3%
Males 20+ yrs                               0.002507                 9.3%
Seniors 55+                                 0.002472                 9.2%
Children 1-2 yrs                            0.014761                54.7%
Children 3-5 yrs                            0.010370                38.4%
Children 6-12 yrs                           0.005172                19.2%
Youth 13-19 yrs                             0.002825                10.5%
Adults 20-49 yrs                            0.002525                 9.4%
Adults 50+ yrs                              0.002473                 9.2%
Females 13-49 yrs                           0.002563                 9.5%