Document ID: EPA-HQ-OPP-2009-0092-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2010-03-24T04:00Z

SEQ CHAPTER \h \r 1 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460      

	OFFICE OF PREVENTION, PESTICIDES

                                                                        
                   AND TOXIC SUBSTANCES

	

MEMORANDUM

Date:  		27 October 2009  

SUBJECT:	Clopyralid – Acute and Chronic Combined Dietary (Food +
Drinking Water) Exposure and Risk Assessments to Evaluate New Uses on
Swiss Chard, Strawberry, and Bushberry (Subgroup 13-07B).

PC Code:  117401 (salt)

	    117403 (acid)	DP Barcode:  D368855

Decision No.:  403248	Registration Nos.:  62719-80, 62719-81, and
62719-84

Petition No.:  8E7481	Regulatory Action:  Section 3 and 24(c)
Registrations

Risk Assessment Type:  Dietary (Single chemical)	Case No.:  NA

TXR No.:  NA	CAS Nos.:	1702-17-6 (acid)

	5774-85-5 (monoethanolamine salt)

MRID No.:  None	40 CFR:  180.431 

FROM:	Michael A. Doherty, Ph.D., Chemist  SEQ CHAPTER \h \r 1 

		Risk Assessment Branch II

Health Effects Division (7509P)

THROUGH:	William Cutchin, Chemist

Donna Davis, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P) 

Richard A. Loranger, Ph.D., Senior Scientist

		Risk Assessment Branch II

		Health Effects Division (7509P)

TO:		Michael A. Doherty, Ph.D., Chemist  SEQ CHAPTER \h \r 1 

		Risk Assessment Branch II

Health Effects Division (7509P)

Barbara Madden, RM 05

		Risk Integration, Minor Use & Emergency Response Branch

Registration Division (7505P)

Executive Summary

Acute and chronic combined dietary (food + drinking water) exposure and
risk assessments were conducted using the Dietary Exposure Evaluation
Model DEEM-FCID™, Version 2.03 which use food consumption data from
the U.S. Department of Agriculture’s Continuing Surveys of Food
Intakes by Individuals (CSFII) from 1994-1996 and 1998.  The analyses
were performed to support Section 3 and Section 24(c) requests for uses
on swiss chard, bushberry Subgroup 13-07B, and strawberry.

The acute and chronic assessments are highly conservative with regard to
protecting human health.  Both assessments assume 100% crop treated and
are based on tolerance-level residues for all commodities.  Modeled
estimates of clopyralid residues in drinking water have been
incorporated into the analyses.  Children 1-2 years old are estimated to
have the highest dietary exposure to clopyralid.  The screening-level
estimates for that subpopulation are 9% of the acute population-adjusted
dose (aPAD) and 24% of the chronic population-adjusted dose (cPAD). 
Generally, HED is concerned about dietary risk when the exposure
estimate exceeds 100% of the PAD.  Therefore, the combined dietary risk
from residues of clopyralid in food and drinking water are below HED’s
level of concern for all population groups.  There are no dietary
exposure considerations that would preclude granting the requested uses
of clopyralid.  An aggregate human health risk assessment is forthcoming
(DP No. D361316).

 

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to the point of departure (POD, NOAEL,
LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  HED is generally
concerned when estimated cancer risk exceeds one in one million.
References which discuss the acute and chronic risk assessments in more
detail are available on the EPA/pesticides web site:  “Available
Information on Assessing Exposure from Pesticides, A User’s Guide,”
21-JUN-2000, web link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see
SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for clopyralid was conducted by
D. Dotson (9 Sept 2002, D284780).

II.	Residue Information

Permanent tolerances are established for residues of clopyralid in/on a
wide variety of plant commodities at levels ranging from 0.5 ppm in/on
stone fruits to 500 ppm in/on grass forage and hay [40 CFR
§180.431(a)], including a tolerance of 1.0 ppm for strawberry. 
Permanent tolerances are also established for residues of clopyralid in
livestock commodities at levels ranging from 0.1 ppm in eggs to 36 ppm
in meat byproducts, except liver, of cattle, goats, horses and sheep. 
The residue of concern for both tolerance enforcement and risk
assessment is the parent compound only.

To support the petitioned-for uses, IR-4 has submitted residue data from
field trials with swiss chard, blueberry, and strawberry (depicting
residues following the annual production practice associated with the
regional registration request).  HED’s recommended tolerances for
these uses, derived from the NAFTA tolerance-harmonization spreadsheet,
are 3.0 ppm for swiss chard, 0.5 ppm for the bushberry subgroup, and 4.0
ppm for strawberry.  HED is recommending that the 4.0-ppm tolerance for
strawberry replace the existing 1.0-ppm tolerance.  Furthermore, HED is
recommending that the existing tolerance of 4.0 ppm for cranberry remain
in place, despite the fact that cranberry is a member of Crop Subgroup
13-07B.  This is due to differences in the use directions for cranberry
versus those for the subgroup in general.  These requested uses do not
impact existing tolerances for livestock commodities.

This is a screening-level assessment; therefore, tolerance-level
residues were used in the analyses along with default processing factors
from DEEM version 7.81.  It was also assumed that 100% of crops with
registered or requested uses of clopyralid were treated.  The inputs for
the dietary assessments are provided in Attachments 1 (acute assessment)
and 2 (chronic assessment).

 Drinking Water Data

The estimated drinking water concentrations (EDWCs) used in the dietary
risk assessment were provided by the Environmental Fate and Effects
Division (EFED) in the following memorandum: “Tier I Drinking Water
Assessment for Proposed New Use of Clopyralid on Swiss Chard, Bushberry
Subgroup 13-07B and Annual Strawberry” (A. Shelby, 9 September 2009,
D361314) and incorporated directly into this dietary assessment.  Water
residues were incorporated in the DEEM-FCID into the food categories
“water, direct, all sources” and “water, indirect, all sources.”
 

 

Modeled estimates of surface water from the FIRST model were used for
both the acute and chronic assessments (Table 1).  These estimates are
greater than those for groundwater via the SCIGROW model as well as the
monitoring data that are available for clopyralid.  The models and their
descriptions are available at the EPA internet site:   HYPERLINK
"http://www.epa.gov/oppefed1/models/water/" 
http://www.epa.gov/oppefed1/models/water/ .  

Table 1.  Estimated Drinking Water Concentrations for Clopyralid.

Drinking Water Source (Model Used)	Use (Rate Modeled)	Maximum Estimated
Drinking Water Concentration (EDWC), ppb

Groundwater (SCIGROW)	Bushberry (0.25 Lbs a.i./A)	Acute And Chronic	0.39

Groundwater (Monitoring)	NAWQA (Alabama)	Acute	13

Surface Water (FIRST)	Bushberry (0.25 Lbs a.i./A)	Acute	41.1

	Bushberry (0.25 Lbs a.i./A)	Chronic	10.8

	Non-crop (0.5 lb a.i./A)	Acute	45.0

	Non-crop (0.5 lb a.i./A)	Chronic	11.9

Surface Water (Monitoring)	NAWQA	Acute	42

For these assessments, the maximum EDWCs of 45 ppm (acute) and 11.9 ppm
(chronic) were used.  As noted in EFED’s evaluation, the monitoring
data are greater than some of the modeled estimates; especially for
groundwater.  HED believes that using the modeled estimates in the
dietary assessment is protective of human health since modeled values
are the maxima for their respective exposure durations. 

IV.	DEEM-FCID™ Program and Consumption Information

Clopyralid acute and chronic dietary exposure assessments were conducted
using the Dietary Exposure Evaluation Model software with the Food
Commodity Intake Database DEEM-FCID™, Version 2.03 which incorporates
consumption data from USDA’s Continuing Surveys of Food Intakes by
Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98 data are based
on the reported consumption of more than 20,000 individuals over two
non-consecutive survey days.  Foods “as consumed” (e.g., apple pie)
are linked to EPA-defined food commodities (e.g. apples, peeled fruit -
cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S,
baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA.  For chronic exposure assessment,
consumption data are averaged for the entire U.S. population and within
population subgroups, but for acute exposure assessment are retained as
individual consumption events.  Based on analysis of the 1994-96, 98
CSFII consumption data, which took into account dietary patterns and
survey respondents, HED concluded that it is most appropriate to report
risk for the following population subgroups: the general U.S.
population, all infants (<1 year old), children 1-2, children 3-5,
children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+
years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., only those who reported
eating relevant commodities/food forms) and a per-capita (i.e., those
who reported eating the relevant commodities as well as those who did
not) basis.  In accordance with HED policy, per capita exposure and risk
are reported for all tiers of analysis.  However, for tiers 1 and 2, any
significant differences in user vs. per capita exposure and risk are
specifically identified and noted in the risk assessment.

V.	Toxicological Information

The toxicology database for clopyralid is incomplete at this time. 
Based on the toxicology data requirements outlined in the recently
revised 40 CFR Part 158, there are additional requirements for acute and
subchronic neurotoxicity studies in the rat (§870.6200a and b), and an
immunotoxicity study (§870.7800).  In addition, a 28-day inhalation
toxicity study in the rat (§870.3465) is required.  Nevertheless, HED
recommends reduction of the FQPA special factor to 1x.  There was no
evidence of increased pre- and/or postnatal qualitative or quantitative
susceptibility in the developmental rat or rabbit studies, or the rat
2-generation reproduction study.  In the developmental rat study, no
developmental effects were seen in at a dose that caused maternal
toxicity.  Although acute and subchronic neurotoxicity studies and an
immunotoxicity study have not been submitted and are required under the
revised 40 CFR Part 158 guidelines, the available subchronic and chronic
studies show no evidence of either neurotoxicity or immunotoxicity at
doses up to or exceeding the limit dose.  The endpoints selected for
risk assessment are therefore considered adequately protective of pre-
and/or postnatal toxicity.

The endpoints for use in dietary risk assessment are summarized in Table
2, below.

Table 2.  Toxicological Doses and Endpoints for Clopyralid for Use
Dietary and Residential  Human Health Risk Assessments.

Exposure/

Scenario	Point of Departure	Uncertainty/FQPA Safety Factors	Level of
Concern for Risk Assessment	Study and Toxicological Effects

Acute Dietary 

(All populations including infants and children) 	NOAEL = 

75 mg/kg	UFA= 10x

UFH= 10x

SFFQPA=1	aRfD=

0.75 mg/kg/day

aPAD=

0.75 mg/kg/day	Developmental Toxicity (oral) – rat

Maternal LOAEL = 250 mg/kg/day, based on decreased body weight gain and
food consumption during GD 6-9.

Chronic Dietary

(All populations including infants and children)	NOAEL= 

15 mg/kg/day 	UFA= 10x

UFH= 10x

SFFQPA=1	cRfD=

0.15 mg/kg/day

cPAD=

0.15 mg/kg/day	2-Year Combined Chronic Toxicity/Carcinogenicity (oral)
– rat

LOAEL = 150 mg/kg/day, based on increased epithelial hyperplasia and
thickening of the limiting ridge of the stomach in both sexes.

Cancer	Classified as “Not likely to be carcinogenic to humans”. 
Quantification of cancer risk is not required.

Point of Departure (POD) = A data point or an estimated point that is
derived from observed dose-response data and  used to mark the beginning
of extrapolation to determine risk associated with lower environmentally
relevant human exposures.  NOAEL = no observed adverse effect level. 
LOAEL = lowest observed adverse effect level.  UF = uncertainty factor. 
UFA = extrapolation from animal to human (interspecies).  UFH =
potential variation in sensitivity among members of the human population
(intraspecies).  FQPA SF = FQPA Safety Factor.  PAD = population
adjusted dose (a = acute, c = chronic).  RfD = reference dose.  MOE =
margin of exposure.  LOC = level of concern.  N/A = not applicable.

VI.	Results 

As stated above, for acute and chronic assessments, HED is concerned
when dietary risk exceeds 100% of the PAD.  The DEEM-FCID™ analyses
estimate the dietary exposure of the U.S. population and various
population subgroups.  The results reported in Table 3 are for the
general U.S. Population, all infants (<1 year old), children 1-2,
children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49,
and adults 50+ years.  Risk estimates are below HED’s level of concern
for all population subgroups.

Table 3.  Summary of the Combined Dietary (Food + Drinking Water)
Exposure and Risk Estimates for Clopyralid.

Population Subgroup	Acute (95th Percentile)	Chronic	Cancer

	Dietary Exposure (mg/kg/day)	% aPAD*	Dietary Exposure

(mg/kg/day)	% cPAD*	Dietary Exposure

(mg/kg/day)	Risk

General U.S. Population	0.035084	5	0.013212	9	N/A	N/A

All Infants (< 1 year old)	0.043768	6	0.012778	9

Children 1-2 years old	0.070616	9	0.035056	23

Children 3-5 years old	0.060428	8	0.031908	21

Children 6-12 years old	0.042390	6	0.021317	14

Youth 13-19 years old	0.025842	3	0.012669	8

Adults 20-49 years old	0.022783	3	0.010403	7

Adults 50+ years old	0.019576	3	0.008967	6

Females 13-49 years old	0.021362	3	0.009685	7

* %PADs are reported to 2 significant figures.  The values for the
highest exposed population for each type of risk assessment are bolded.

VII.	Characterization of Inputs/Outputs

Highly conservative, health-protective assumptions have been used
throughout the acute and chronic dietary assessments for clopyralid. 
The resulting exposure and risk estimates likely overestimate any actual
dietary exposures to clopyralid that may occur due to the registered and
requested uses.

VIII.	Conclusions

Highly conservative assessments indicate that there are no acute or
chronic dietary (food + drinking water) exposure concerns for
clopyralid.  There are no dietary risk considerations that would
preclude granting the requested uses.  A full aggregate human health
risk assessment is forthcoming (D361316).

IX.	List of Attachments

Attachment 1.  Inputs for the acute dietary exposure assessment of
clopyralid

Attachment 2.  Inputs for the chronic dietary exposure assessment of
clopyralid.

Attachment 3.  Summary of the acute dietary exposure and risk estimates
for clopyralid.

Attachment 4.  Summary of the chronic dietary exposure and risk
estimates for clopyralid.

Attachment 1.  Inputs for the acute dietary exposure assessment of
clopyralid

U.S. Environmental Protection Agency                                
Ver. 2.02

DEEM-FCID Acute analysis for CLOPYRALID

Residue file name: C:\Documents and Settings\mdoherty\My
Documents\Chemistry Reviews\Clopyralid\2009\117403-2009 Acute.R98

Analysis Date 09-22-2009             Residue file dated:
09-22-2009/09:31:12/8

Reference dose: aRfD = 0.75 mg/kg bw/day  NOEL = 75 mg/kg bw/day

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Food Name                         (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

12000120 12   Apricot                            0.500000   1.000 
1.0001E6239

12000121 12   Apricot-babyfood                   0.500000   1.000 
1.0001E6239

12000130 12   Apricot, dried                     0.500000   6.000 
1.0001E6239

12000140 12   Apricot, juice                     0.500000   1.000 
1.0001E6239

12000141 12   Apricot, juice-babyfood            0.500000   1.000 
1.0001E6239

95000190 O    Asparagus                          1.000000   1.000 
1.0001E3979

15000250 15   Barley, pearled barley             3.000000   1.000 
1.0004F3054

15000251 15   Barley, pearled barley-babyfood    3.000000   1.000 
1.0004F3054

15000260 15   Barley, flour                      3.000000   1.000 
1.0004F3054

15000261 15   Barley, flour-babyfood             3.000000   1.000 
1.0004F3054

15000270 15   Barley, bran                      12.000000   1.000 
1.0004F3054

21000440 M    Beef, meat                         1.000000   1.000 
1.0001F2439

21000441 M    Beef, meat-babyfood                1.000000   1.000 
1.0001F2439

21000450 M    Beef, meat, dried                  1.000000   1.920 
1.0001F2439

21000460 M    Beef, meat byproducts             36.000000   1.000 
1.0001F2439

21000461 M    Beef, meat byproducts-babyfood    36.000000   1.000 
1.0001F2439

21000470 M    Beef, fat                          1.000000   1.000 
1.0001F2439

21000471 M    Beef,fat-babyfood                  1.000000   1.000 
1.0001F2439

21000480 M    Beef, kidney                      36.000000   1.000 
1.0001F2439

21000490 M    Beef, liver                        3.000000   1.000 
1.0001F2439

21000491 M    Beef, liver-babyfood               3.000000   1.000 
1.0001F2439

01010500 1AB  Beet, garden, roots                4.000000   1.000 
1.0001E6333

01010501 1AB  Beet, garden, roots-babyfood       4.000000   1.000 
1.0001E6333

02000510 2    Beet, garden, tops                 3.000000   1.000 
1.0001E6333

01010520 1A   Beet, sugar                        2.000000   0.100 
1.0008F3600

01010521 1A   Beet, sugar-babyfood               2.000000   0.100 
1.0008F3600

01010530 1A   Beet, sugar, molasses             10.000000   1.000 
1.0008F3600

01010531 1A   Beet, sugar, molasses-babyfood    10.000000   1.000 
1.0008F3600

13020570 13B  Blueberry                          0.500000   1.000 
1.0008E7481

13020571 13B  Blueberry-babyfood                 0.500000   1.000 
1.0008E7481

05010610 5A   Broccoli                           2.000000   1.000 
1.0001E3999

05010611 5A   Broccoli-babyfood                  2.000000   1.000 
1.0001E3999

05010620 5A   Broccoli, Chinese                  2.000000   1.000 
1.0001E3999

05010640 5A   Brussels sprouts                   2.000000   1.000 
1.0001E3999

05010690 5A   Cabbage                            2.000000   1.000 
1.0001E3999

05010710 5A   Cabbage, Chinese, napa             2.000000   1.000 
1.0001E3999

05010720 5A   Cabbage, Chinese, mustard          2.000000   1.000 
1.0001E3999

05010830 5A   Cauliflower                        2.000000   1.000 
1.0001E3999

12000900 12   Cherry                             0.500000   1.000 
1.0001E6329

12000901 12   Cherry-babyfood                    0.500000   1.000 
1.0001E6329

12000910 12   Cherry, juice                      0.500000   1.500 
1.0001E6329

12000911 12   Cherry, juice-babyfood             0.500000   1.500 
1.0001E6329

40000930 P    Chicken, meat                      0.200000   1.000 
1.0004F3054

40000931 P    Chicken, meat-babyfood             0.200000   1.000 
1.0004F3054

40000940 P    Chicken, liver                     0.200000   1.000 
1.0004F3054

40000950 P    Chicken, meat byproducts           0.200000   1.000 
1.0004F3054

40000951 P    Chicken, meat byproducts-babyfoo   0.200000   1.000 
1.0004F3054

40000960 P    Chicken, fat                       0.200000   1.000 
1.0004F3054

40000961 P    Chicken, fat-babyfood              0.200000   1.000 
1.0004F3054

40000970 P    Chicken, skin                      0.200000   1.000 
1.0004F3054

40000971 P    Chicken, skin-babyfood             0.200000   1.000 
1.0004F3054

15001200 15   Corn, field, flour                 1.000000   1.000 
1.0004F4379

15001201 15   Corn, field, flour-babyfood        1.000000   1.000 
1.0004F4379

15001210 15   Corn, field, meal                  1.000000   1.000 
1.0004F4379

15001220 15   Corn, field, bran                  1.000000   1.000 
1.0004F4379

15001230 15   Corn, field, starch                1.000000   1.000 
1.0004F4379

15001231 15   Corn, field, starch-babyfood       1.000000   1.000 
1.0004F4379

15001240 15   Corn, field, syrup                 1.000000   1.500 
1.0004F4379

15001241 15   Corn, field, syrup-babyfood        1.000000   1.500 
1.0004F4379

15001250 15   Corn, field, oil                   1.000000   1.000 
1.0004F4379

15001251 15   Corn, field, oil-babyfood          1.000000   1.000 
1.0004F4379

15001260 15   Corn, pop                          1.000000   1.000 
1.0004F4379

15001270 15   Corn, sweet                        1.000000   1.000 
1.0004F4379

15001271 15   Corn, sweet-babyfood               1.000000   1.000 
1.0004F4379

95001300 O    Cranberry                          4.000000   1.000 
1.0001E6340

95001301 O    Cranberry-babyfood                 4.000000   1.000 
1.0001E6340

95001310 O    Cranberry, dried                   4.000000   4.000 
1.0001E6340

          Full comment: 1E6340 Conc. factor from cherry

95001320 O    Cranberry, juice                   4.000000   1.100 
1.0001E6340

95001321 O    Cranberry, juice-babyfood          4.000000   1.100 
1.0001E6340

13021360 13B  Currant                            0.500000   1.000 
1.0008E7481

70001450 P    Egg, whole                         0.100000   1.000 
1.0004F3054

70001451 P    Egg, whole-babyfood                0.100000   1.000 
1.0004F3054

70001460 P    Egg, white                         0.100000   1.000 
1.0004F3054

70001461 P    Egg, white (solids)-babyfood       0.100000   1.000 
1.0004F3054

70001470 P    Egg, yolk                          0.100000   1.000 
1.0004F3054

70001471 P    Egg, yolk-babyfood                 0.100000   1.000 
1.0004F3054

13021490 13B  Elderberry                         0.500000   1.000 
1.0008E7481

20001630 20   Flaxseed, oil                      3.000000   1.000 
1.0001E6227

23001690 M    Goat, meat                         1.000000   1.000 
1.0001F2439

23001700 M    Goat, meat byproducts             36.000000   1.000 
1.0001F2439

23001710 M    Goat, fat                          1.000000   1.000 
1.0001F2439

23001720 M    Goat, kidney                      36.000000   1.000 
1.0001F2439

23001730 M    Goat, liver                        3.000000   1.000 
1.0001F2439

13021740 13B  Gooseberry                         0.500000   1.000 
1.0008E7481

95001880 O    Hop                                5.000000   1.000 
1.0001E6283

24001890 M    Horse, meat                        1.000000   1.000 
1.0001F2439

13021910 13B  Huckleberry                        0.500000   1.000 
1.0008E7481

05011960 5A   Kohlrabi                           2.000000   1.000 
1.0001E3999

28002210 M    Meat, game                         1.000000   1.000 
1.0001F2439

27002220 D    Milk, fat                          0.200000   1.000 
1.0001F2439

27002221 D    Milk, fat - baby food/infant for   0.200000   1.000 
1.0001F2439

27012230 D    Milk, nonfat solids                0.200000   1.000 
1.0001F2439

27012231 D    Milk, nonfat solids-baby food/in   0.200000   1.000 
1.0001F2439

27022240 D    Milk, water                        0.200000   1.000 
1.0001F2439

27022241 D    Milk, water-babyfood/infant form   0.200000   1.000 
1.0001F2439

27032251 D    Milk, sugar (lactose)-baby food/   0.200000   1.000 
1.0001F2439

05022290 5B   Mustard greens                     5.000000   1.000 
1.0001E6334

12002300 12   Nectarine                          0.500000   1.000 
1.0001E6329

15002310 15   Oat, bran                          3.000000   1.000 
1.0004F3054

15002320 15   Oat, flour                         3.000000   1.000 
1.0004F3054

15002321 15   Oat, flour-babyfood                3.000000   1.000 
1.0004F3054

15002330 15   Oat, groats/rolled oats            3.000000   1.000 
1.0004F3054

15002331 15   Oat, groats/rolled oats-babyfood   3.000000   1.000 
1.0004F3054

12002600 12   Peach                              0.500000   1.000 
1.0001E6329

12002601 12   Peach-babyfood                     0.500000   1.000 
1.0001E6329

12002610 12   Peach, dried                       0.500000   7.000 
1.0001E6329

12002611 12   Peach, dried-babyfood              0.500000   1.000 
1.0001E6329

12002620 12   Peach, juice                       0.500000   1.000 
1.0001E6329

12002621 12   Peach, juice-babyfood              0.500000   1.000 
1.0001E6329

95002750 O    Peppermint                         3.000000   1.000  1.000

95002760 O    Peppermint, oil                    3.000000   1.000  1.000

12002850 12   Plum                               0.500000   1.000 
1.0001E6329

12002851 12   Plum-babyfood                      0.500000   1.000 
1.0001E6329

12002860 12   Plum, prune, fresh                 0.500000   1.000 
1.0001E6329

12002861 12   Plum, prune, fresh-babyfood        0.500000   1.000 
1.0001E6329

12002870 12   Plum, prune, dried                 1.500000   1.000 
1.0001E6329

12002871 12   Plum, prune, dried-babyfood        1.500000   1.000 
1.0001E6329

12002880 12   Plum, prune, juice                 0.500000   1.400 
1.0001E6329

12002881 12   Plum, prune, juice-babyfood        0.500000   1.400 
1.0001E6329

25002900 M    Pork, meat                         0.200000   1.000 
1.0001F2439

25002901 M    Pork, meat-babyfood                0.200000   1.000 
1.0001F2439

25002910 M    Pork, skin                         0.200000   1.000 
1.0001F2439

25002920 M    Pork, meat byproducts              0.200000   1.000 
1.0001F2439

25002921 M    Pork, meat byproducts-babyfood     0.200000   1.000 
1.0001F2439

25002930 M    Pork, fat                          0.200000   1.000 
1.0001F2439

25002931 M    Pork, fat-babyfood                 0.200000   1.000 
1.0001F2439

25002940 M    Pork, kidney                       0.200000   1.000 
1.0001F2439

25002950 M    Pork, liver                        0.200000   1.000 
1.0001F2439

60003010 P    Poultry, other, meat               0.200000   1.000 
1.0001F2439

60003020 P    Poultry, other, liver              0.200000   1.000 
1.0001F2439

60003030 P    Poultry, other, meat byproducts    0.200000   1.000 
1.0001F2439

60003040 P    Poultry, other, fat                0.200000   1.000 
1.0001F2439

60003050 P    Poultry, other, skin               0.200000   1.000 
1.0001F2439

29003120 M    Rabbit, meat                       1.000000   1.000 
1.0001F2439

20003190 20   Rapeseed, oil                      3.000000   1.000 
1.0001E6291

20003191 20   Rapeseed, oil-babyfood             3.000000   1.000 
1.0001E6291

26003390 M    Sheep, meat                        1.000000   1.000 
1.0001F2439

26003391 M    Sheep, meat-babyfood               1.000000   1.000 
1.0001F2439

26003400 M    Sheep, meat byproducts            36.000000   1.000 
1.0001F2439

26003410 M    Sheep, fat                         1.000000   1.000 
1.0001F2439

26003411 M    Sheep, fat-babyfood                1.000000   1.000 
1.0001F2439

26003420 M    Sheep, kidney                     36.000000   1.000 
1.0001F2439

26003430 M    Sheep, liver                       3.000000   1.000 
1.0001F2439

95003520 O    Spearmint                          3.000000   1.000  1.000

95003530 O    Spearmint, oil                     3.000000   1.000  1.000

04013550 4A   Spinach                            5.000000   1.000 
1.0001E6320

04013551 4A   Spinach-babyfood                   5.000000   1.000 
1.0001E6320

95003590 O    Strawberry                         4.000000   1.000 
1.0008E7481

95003591 O    Strawberry-babyfood                4.000000   1.000 
1.0008E7481

95003600 O    Strawberry, juice                  4.000000   1.000 
1.0008E7481

95003601 O    Strawberry, juice-babyfood         4.000000   1.000 
1.0008E7481

04023670 4B   Swiss chard                        3.000000   1.000 
1.0008E7481

15003810 15   Triticale, flour                   3.000000   1.000 
1.0004F3054

50003820 P    Turkey, meat                       0.200000   1.000 
1.0001F2439

50003821 P    Turkey, meat-babyfood              0.200000   1.000 
1.0001F2439

50003830 P    Turkey, liver                      0.200000   1.000 
1.0001F2439

50003831 P    Turkey, liver-babyfood             0.200000   1.000 
1.0001F2439

50003840 P    Turkey, meat byproducts            0.200000   1.000 
1.0001F2439

50003841 P    Turkey, meat byproducts-babyfood   0.200000   1.000 
1.0001F2439

50003850 P    Turkey, fat                        0.200000   1.000 
1.0001F2439

50003851 P    Turkey, fat-babyfood               0.200000   1.000 
1.0001F2439

50003860 P    Turkey, skin                       0.200000   1.000 
1.0001F2439

50003861 P    Turkey, skin-babyfood              0.200000   1.000 
1.0001F2439

01013880 1AB  Turnip, roots                      1.000000   1.000 
1.0001E6335

05023890 5B   Turnip, greens                     4.000000   1.000 
1.0001E6335

86010000 O    Water, direct, all sources         0.045000   1.000 
1.000FIRST 

          Full comment: FIRST Acute Non-crop Use

86020000 O    Water, indirect, all sources       0.045000   1.000 
1.000FIRST 

          Full comment: FIRST Acute Non-crop Use

15004010 15   Wheat, grain                       3.000000   1.000 
1.0004F3054

15004011 15   Wheat, grain-babyfood              3.000000   1.000 
1.0004F3054

15004020 15   Wheat, flour                       3.000000   1.000 
1.0004F3054

15004021 15   Wheat, flour-babyfood              3.000000   1.000 
1.0004F3054

15004030 15   Wheat, germ                       12.000000   1.000 
1.0004F3054

15004040 15   Wheat, bran                       12.000000   1.000 
1.0004F3054

Attachment 2.  Inputs for the chronic dietary exposure assessment of
clopyralid.

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for CLOPYRALID                        
1994-98 data

Residue file: C:\Documents and Settings\mdoherty\My Documents\Chemistry
Reviews\Clopyralid\2009\117403-2009 Chronic.R98

                                                           Adjust. #2
NOT used

Analysis Date 09-22-2009             Residue file dated:
09-22-2009/09:32:21/8

Reference dose (RfD) = 0.15 mg/kg bw/day

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

12000120 12   Apricot                            0.500000   1.000     
1.000   1E6239

12000121 12   Apricot-babyfood                   0.500000   1.000     
1.000   1E6239

12000130 12   Apricot, dried                     0.500000   6.000     
1.000   1E6239

12000140 12   Apricot, juice                     0.500000   1.000     
1.000   1E6239

12000141 12   Apricot, juice-babyfood            0.500000   1.000     
1.000   1E6239

95000190 O    Asparagus                          1.000000   1.000     
1.000   1E3979

15000250 15   Barley, pearled barley             3.000000   1.000     
1.000   4F3054

15000251 15   Barley, pearled barley-babyfood    3.000000   1.000     
1.000   4F3054

15000260 15   Barley, flour                      3.000000   1.000     
1.000   4F3054

15000261 15   Barley, flour-babyfood             3.000000   1.000     
1.000   4F3054

15000270 15   Barley, bran                      12.000000   1.000     
1.000   4F3054

21000440 M    Beef, meat                         1.000000   1.000     
1.000   1F2439

21000441 M    Beef, meat-babyfood                1.000000   1.000     
1.000   1F2439

21000450 M    Beef, meat, dried                  1.000000   1.920     
1.000   1F2439

21000460 M    Beef, meat byproducts             36.000000   1.000     
1.000   1F2439

21000461 M    Beef, meat byproducts-babyfood    36.000000   1.000     
1.000   1F2439

21000470 M    Beef, fat                          1.000000   1.000     
1.000   1F2439

21000471 M    Beef,fat-babyfood                  1.000000   1.000     
1.000   1F2439

21000480 M    Beef, kidney                      36.000000   1.000     
1.000   1F2439

21000490 M    Beef, liver                        3.000000   1.000     
1.000   1F2439

21000491 M    Beef, liver-babyfood               3.000000   1.000     
1.000   1F2439

01010500 1AB  Beet, garden, roots                4.000000   1.000     
1.000   1E6333

01010501 1AB  Beet, garden, roots-babyfood       4.000000   1.000     
1.000   1E6333

02000510 2    Beet, garden, tops                 3.000000   1.000     
1.000   1E6333

01010520 1A   Beet, sugar                        2.000000   0.100     
1.000   8F3600

01010521 1A   Beet, sugar-babyfood               2.000000   0.100     
1.000   8F3600

01010530 1A   Beet, sugar, molasses             10.000000   1.000     
1.000   8F3600

01010531 1A   Beet, sugar, molasses-babyfood    10.000000   1.000     
1.000   8F3600

13020570 13B  Blueberry                          0.500000   1.000     
1.000   8E7481

13020571 13B  Blueberry-babyfood                 0.500000   1.000     
1.000   8E7481

05010610 5A   Broccoli                           2.000000   1.000     
1.000   1E3999

05010611 5A   Broccoli-babyfood                  2.000000   1.000     
1.000   1E3999

05010620 5A   Broccoli, Chinese                  2.000000   1.000     
1.000   1E3999

05010640 5A   Brussels sprouts                   2.000000   1.000     
1.000   1E3999

05010690 5A   Cabbage                            2.000000   1.000     
1.000   1E3999

05010710 5A   Cabbage, Chinese, napa             2.000000   1.000     
1.000   1E3999

05010720 5A   Cabbage, Chinese, mustard          2.000000   1.000     
1.000   1E3999

05010830 5A   Cauliflower                        2.000000   1.000     
1.000   1E3999

12000900 12   Cherry                             0.500000   1.000     
1.000   1E6329

12000901 12   Cherry-babyfood                    0.500000   1.000     
1.000   1E6329

12000910 12   Cherry, juice                      0.500000   1.500     
1.000   1E6329

12000911 12   Cherry, juice-babyfood             0.500000   1.500     
1.000   1E6329

40000930 P    Chicken, meat                      0.200000   1.000     
1.000   4F3054

40000931 P    Chicken, meat-babyfood             0.200000   1.000     
1.000   4F3054

40000940 P    Chicken, liver                     0.200000   1.000     
1.000   4F3054

40000950 P    Chicken, meat byproducts           0.200000   1.000     
1.000   4F3054

40000951 P    Chicken, meat byproducts-babyfoo   0.200000   1.000     
1.000   4F3054

40000960 P    Chicken, fat                       0.200000   1.000     
1.000   4F3054

40000961 P    Chicken, fat-babyfood              0.200000   1.000     
1.000   4F3054

40000970 P    Chicken, skin                      0.200000   1.000     
1.000   4F3054

40000971 P    Chicken, skin-babyfood             0.200000   1.000     
1.000   4F3054

15001200 15   Corn, field, flour                 1.000000   1.000     
1.000   4F4379

15001201 15   Corn, field, flour-babyfood        1.000000   1.000     
1.000   4F4379

15001210 15   Corn, field, meal                  1.000000   1.000     
1.000   4F4379

15001220 15   Corn, field, bran                  1.000000   1.000     
1.000   4F4379

15001230 15   Corn, field, starch                1.000000   1.000     
1.000   4F4379

15001231 15   Corn, field, starch-babyfood       1.000000   1.000     
1.000   4F4379

15001240 15   Corn, field, syrup                 1.000000   1.500     
1.000   4F4379

15001241 15   Corn, field, syrup-babyfood        1.000000   1.500     
1.000   4F4379

15001250 15   Corn, field, oil                   1.000000   1.000     
1.000   4F4379

15001251 15   Corn, field, oil-babyfood          1.000000   1.000     
1.000   4F4379

15001260 15   Corn, pop                          1.000000   1.000     
1.000   4F4379

15001270 15   Corn, sweet                        1.000000   1.000     
1.000   4F4379

15001271 15   Corn, sweet-babyfood               1.000000   1.000     
1.000   4F4379

95001300 O    Cranberry                          4.000000   1.000     
1.000   1E6340

95001301 O    Cranberry-babyfood                 4.000000   1.000     
1.000   1E6340

95001310 O    Cranberry, dried                   4.000000   4.000     
1.000   1E6340 Conc. factor from cherry

95001320 O    Cranberry, juice                   4.000000   1.100     
1.000   1E6340

95001321 O    Cranberry, juice-babyfood          4.000000   1.100     
1.000   1E6340

13021360 13B  Currant                            0.500000   1.000     
1.000   8E7481

70001450 P    Egg, whole                         0.100000   1.000     
1.000   4F3054

70001451 P    Egg, whole-babyfood                0.100000   1.000     
1.000   4F3054

70001460 P    Egg, white                         0.100000   1.000     
1.000   4F3054

70001461 P    Egg, white (solids)-babyfood       0.100000   1.000     
1.000   4F3054

70001470 P    Egg, yolk                          0.100000   1.000     
1.000   4F3054

70001471 P    Egg, yolk-babyfood                 0.100000   1.000     
1.000   4F3054

13021490 13B  Elderberry                         0.500000   1.000     
1.000   8E7481

20001630 20   Flaxseed, oil                      3.000000   1.000     
1.000   1E6227

23001690 M    Goat, meat                         1.000000   1.000     
1.000   1F2439

23001700 M    Goat, meat byproducts             36.000000   1.000     
1.000   1F2439

23001710 M    Goat, fat                          1.000000   1.000     
1.000   1F2439

23001720 M    Goat, kidney                      36.000000   1.000     
1.000   1F2439

23001730 M    Goat, liver                        3.000000   1.000     
1.000   1F2439

13021740 13B  Gooseberry                         0.500000   1.000     
1.000   8E7481

95001880 O    Hop                                5.000000   1.000     
1.000   1E6283

24001890 M    Horse, meat                        1.000000   1.000     
1.000   1F2439

13021910 13B  Huckleberry                        0.500000   1.000     
1.000   8E7481

05011960 5A   Kohlrabi                           2.000000   1.000     
1.000   1E3999

28002210 M    Meat, game                         1.000000   1.000     
1.000   1F2439

27002220 D    Milk, fat                          0.200000   1.000     
1.000   1F2439

27002221 D    Milk, fat - baby food/infant for   0.200000   1.000     
1.000   1F2439

27012230 D    Milk, nonfat solids                0.200000   1.000     
1.000   1F2439

27012231 D    Milk, nonfat solids-baby food/in   0.200000   1.000     
1.000   1F2439

27022240 D    Milk, water                        0.200000   1.000     
1.000   1F2439

27022241 D    Milk, water-babyfood/infant form   0.200000   1.000     
1.000   1F2439

27032251 D    Milk, sugar (lactose)-baby food/   0.200000   1.000     
1.000   1F2439

05022290 5B   Mustard greens                     5.000000   1.000     
1.000   1E6334

12002300 12   Nectarine                          0.500000   1.000     
1.000   1E6329

15002310 15   Oat, bran                          3.000000   1.000     
1.000   4F3054

15002320 15   Oat, flour                         3.000000   1.000     
1.000   4F3054

15002321 15   Oat, flour-babyfood                3.000000   1.000     
1.000   4F3054

15002330 15   Oat, groats/rolled oats            3.000000   1.000     
1.000   4F3054

15002331 15   Oat, groats/rolled oats-babyfood   3.000000   1.000     
1.000   4F3054

12002600 12   Peach                              0.500000   1.000     
1.000   1E6329

12002601 12   Peach-babyfood                     0.500000   1.000     
1.000   1E6329

12002610 12   Peach, dried                       0.500000   7.000     
1.000   1E6329

12002611 12   Peach, dried-babyfood              0.500000   1.000     
1.000   1E6329

12002620 12   Peach, juice                       0.500000   1.000     
1.000   1E6329

12002621 12   Peach, juice-babyfood              0.500000   1.000     
1.000   1E6329

95002750 O    Peppermint                         3.000000   1.000     
1.000   

95002760 O    Peppermint, oil                    3.000000   1.000     
1.000   

12002850 12   Plum                               0.500000   1.000     
1.000   1E6329

12002851 12   Plum-babyfood                      0.500000   1.000     
1.000   1E6329

12002860 12   Plum, prune, fresh                 0.500000   1.000     
1.000   1E6329

12002861 12   Plum, prune, fresh-babyfood        0.500000   1.000     
1.000   1E6329

12002870 12   Plum, prune, dried                 1.500000   1.000     
1.000   1E6329

12002871 12   Plum, prune, dried-babyfood        1.500000   1.000     
1.000   1E6329

12002880 12   Plum, prune, juice                 0.500000   1.400     
1.000   1E6329

12002881 12   Plum, prune, juice-babyfood        0.500000   1.400     
1.000   1E6329

25002900 M    Pork, meat                         0.200000   1.000     
1.000   1F2439

25002901 M    Pork, meat-babyfood                0.200000   1.000     
1.000   1F2439

25002910 M    Pork, skin                         0.200000   1.000     
1.000   1F2439

25002920 M    Pork, meat byproducts              0.200000   1.000     
1.000   1F2439

25002921 M    Pork, meat byproducts-babyfood     0.200000   1.000     
1.000   1F2439

25002930 M    Pork, fat                          0.200000   1.000     
1.000   1F2439

25002931 M    Pork, fat-babyfood                 0.200000   1.000     
1.000   1F2439

25002940 M    Pork, kidney                       0.200000   1.000     
1.000   1F2439

25002950 M    Pork, liver                        0.200000   1.000     
1.000   1F2439

60003010 P    Poultry, other, meat               0.200000   1.000     
1.000   1F2439

60003020 P    Poultry, other, liver              0.200000   1.000     
1.000   1F2439

60003030 P    Poultry, other, meat byproducts    0.200000   1.000     
1.000   1F2439

60003040 P    Poultry, other, fat                0.200000   1.000     
1.000   1F2439

60003050 P    Poultry, other, skin               0.200000   1.000     
1.000   1F2439

29003120 M    Rabbit, meat                       1.000000   1.000     
1.000   1F2439

20003190 20   Rapeseed, oil                      3.000000   1.000     
1.000   1E6291

20003191 20   Rapeseed, oil-babyfood             3.000000   1.000     
1.000   1E6291

26003390 M    Sheep, meat                        1.000000   1.000     
1.000   1F2439

26003391 M    Sheep, meat-babyfood               1.000000   1.000     
1.000   1F2439

26003400 M    Sheep, meat byproducts            36.000000   1.000     
1.000   1F2439

26003410 M    Sheep, fat                         1.000000   1.000     
1.000   1F2439

26003411 M    Sheep, fat-babyfood                1.000000   1.000     
1.000   1F2439

26003420 M    Sheep, kidney                     36.000000   1.000     
1.000   1F2439

26003430 M    Sheep, liver                       3.000000   1.000     
1.000   1F2439

95003520 O    Spearmint                          3.000000   1.000     
1.000   

95003530 O    Spearmint, oil                     3.000000   1.000     
1.000   

04013550 4A   Spinach                            5.000000   1.000     
1.000   1E6320

04013551 4A   Spinach-babyfood                   5.000000   1.000     
1.000   1E6320

95003590 O    Strawberry                         4.000000   1.000     
1.000   8E7481

95003591 O    Strawberry-babyfood                4.000000   1.000     
1.000   8E7481

95003600 O    Strawberry, juice                  4.000000   1.000     
1.000   8E7481

95003601 O    Strawberry, juice-babyfood         4.000000   1.000     
1.000   8E7481

04023670 4B   Swiss chard                        3.000000   1.000     
1.000   8E7481

15003810 15   Triticale, flour                   3.000000   1.000     
1.000   4F3054

50003820 P    Turkey, meat                       0.200000   1.000     
1.000   1F2439

50003821 P    Turkey, meat-babyfood              0.200000   1.000     
1.000   1F2439

50003830 P    Turkey, liver                      0.200000   1.000     
1.000   1F2439

50003831 P    Turkey, liver-babyfood             0.200000   1.000     
1.000   1F2439

50003840 P    Turkey, meat byproducts            0.200000   1.000     
1.000   1F2439

50003841 P    Turkey, meat byproducts-babyfood   0.200000   1.000     
1.000   1F2439

50003850 P    Turkey, fat                        0.200000   1.000     
1.000   1F2439

50003851 P    Turkey, fat-babyfood               0.200000   1.000     
1.000   1F2439

50003860 P    Turkey, skin                       0.200000   1.000     
1.000   1F2439

50003861 P    Turkey, skin-babyfood              0.200000   1.000     
1.000   1F2439

01013880 1AB  Turnip, roots                      1.000000   1.000     
1.000   1E6335

05023890 5B   Turnip, greens                     4.000000   1.000     
1.000   1E6335

86010000 O    Water, direct, all sources         0.011900   1.000     
1.000   FIRST Chronic Non-crop Use

86020000 O    Water, indirect, all sources       0.011900   1.000     
1.000   FIRST Chronic Non-crop Use

15004010 15   Wheat, grain                       3.000000   1.000     
1.000   4F3054

15004011 15   Wheat, grain-babyfood              3.000000   1.000     
1.000   4F3054

15004020 15   Wheat, flour                       3.000000   1.000     
1.000   4F3054

15004021 15   Wheat, flour-babyfood              3.000000   1.000     
1.000   4F3054

15004030 15   Wheat, germ                       12.000000   1.000     
1.000   4F3054

15004040 15   Wheat, bran                       12.000000   1.000     
1.000   4F3054

Attachment 3.  Summary of the acute dietary exposure and risk estimates
for clopyralid.

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for CLOPYRALID                         
(1994-98 data)

Residue file: 117403-2009 Acute.R98               Adjustment factor #2
NOT used.

Analysis Date: 09-22-2009/09:35:18    Residue file dated:
09-22-2009/09:31:12/8

NOEL (Acute) =  75.000000 mg/kg body-wt/day

Daily totals for food and foodform consumption used.

Run Comment: ""

========================================================================
=======

Summary calculations (per capita):

      95th Percentile             99th Percentile             99.9th
Percentile

 Exposure  % aRfD     MOE    Exposure  % aRfD     MOE    Exposure  %
aRfD     MOE  

---------- ------- -------- ---------- ------- -------- ----------
------- --------

U.S. Population:

  0.035084    4.68    2137    0.056291    7.51    1332    0.099454  
13.26     754  

All infants:

  0.043768    5.84    1713    0.068045    9.07    1102    0.118739  
15.83     631  

Children 1-2 yrs:

  0.070616    9.42    1062    0.099413   13.26     754    0.241641  
32.22     310  

Children 3-5 yrs:

  0.060428    8.06    1241    0.086358   11.51     868    0.157416  
20.99     476  

Children 6-12 yrs:

  0.042390    5.65    1769    0.057115    7.62    1313    0.098244  
13.10     763  

Youth 13-19 yrs:

  0.025842    3.45    2902    0.043040    5.74    1742    0.083194  
11.09     901  

Adults 20-49 yrs:

  0.022783    3.04    3291    0.034900    4.65    2148    0.057647   
7.69    1301  

Adults 50+ yrs:

  0.019576    2.61    3831    0.030007    4.00    2499    0.049151   
6.55    1525  

Females 13-49 yrs:

  0.021362    2.85    3510    0.031090    4.15    2412    0.050494   
6.73    1485  

Attachment 4.  Summary of the chronic dietary exposure and risk
estimates for clopyralid.

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for CLOPYRALID                       (1994-98
data)

Residue file name: C:\Documents and Settings\mdoherty\My
Documents\Chemistry Reviews\Clopyralid\2009\117403-2009 Chronic.R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 09-22-2009/09:33:15     Residue file dated:
09-22-2009/09:32:21/8

Reference dose (RfD, Chronic) = .15 mg/kg bw/day

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.013212                
8.8%

U.S. Population (spring season)             0.013517                
9.0%

U.S. Population (summer season)             0.013180                
8.8%

U.S. Population (autumn season)             0.013053                
8.7%

U.S. Population (winter season)             0.013107                
8.7%

Northeast region                            0.013495                
9.0%

Midwest region                              0.013920                
9.3%

Southern region                             0.012456                
8.3%

Western region                              0.013400                
8.9%

Hispanics                                   0.013458                
9.0%

Non-hispanic whites                         0.013086                
8.7%

Non-hispanic blacks                         0.013803                
9.2%

Non-hisp/non-white/non-black                0.013005                
8.7%

All infants (< 1 year)                      0.012778                
8.5%

Nursing infants                             0.005326                
3.6%

Non-nursing infants                         0.015607               
10.4%

Children 1-6  yrs                           0.032165               
21.4%

Children 7-12 yrs                           0.020267               
13.5%

Females 13-19 (not preg or nursing)         0.011014                
7.3%

Females 20+ (not preg or nursing)           0.009012                
6.0%

	

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Females 13-50 yrs                           0.010319                
6.9%

Females 13+ (preg/not nursing)              0.011001                
7.3%

Females 13+ (nursing)                       0.012041                
8.0%

Males 13-19 yrs                             0.014231                
9.5%

Males 20+ yrs                               0.010759                
7.2%

Seniors 55+                                 0.008885                
5.9%

Children 1-2 yrs                            0.035056               
23.4%

Children 3-5 yrs                            0.031908               
21.3%

Children 6-12 yrs                           0.021317               
14.2%

Youth 13-19 yrs                             0.012669                
8.4%

Adults 20-49 yrs                            0.010403                
6.9%

Adults 50+ yrs                              0.008967                
6.0%

Females 13-49 yrs                           0.009685                
6.5%

------------------------------------------------------------------------
-------

Clopyralid (117401/117403)	Dietary Exposure and Risk Assessment	DP
Number:  368855

Page   PAGE  1  of   NUMPAGES  14