Document ID: EPA-HQ-OPP-2007-0116-0004
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2007-12-31T05:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF              

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES 

MEMORANDUM 

DATE:  	September 26, 2007

SUBJECT:	Dimethenamid-p.  Acute and Chronic Dietary Exposure Assessments
for the   IR-4 Petition Proposing Tolerances on Winter Squash, Pumpkin,
Radish (Roots and Tops), Rutabaga (Roots and Tops), Turnip (Roots, Tops
and Greens) and on Hops, Dried Cones (PP#: 6E7152).

PC Code:		129051 and 120051

Decision Number:	372743

DP Number:		341975

REVIEWER:	Breann Hanson, Biologist

Alternative Risk Integration Assessment (ARIA)

Risk Integration Minor Use and Emergency Response Branch
(RIMUERB)/Registration Division (RD) (7505P)

THROUGH:	William Cutchin, Chemist

		ARIA

		RIMUERB/RD (7505P)

AND

Felecia Fort, Chemist

		Dietary Exposure Science Advisory Council (DESAC)

		Health Effects Division (7509P)

TO:		Breann Hanson, Biologist

ARIA

RIMUERB/ RD (7505P)

Executive Summary

The purpose of this memorandum is to report the results of a dietary
(food + drinking water) exposure analysis for an Interregional Research
Project No. 4 (IR-4) petition (PP# 6E7152) for the herbicide
dimethenamid-P for use on winter squash, pumpkin, radish (roots and
tops), rutabaga (roots and tops), turnip (roots, tops and greens) and on
hops, dried cones.  Acute and chronic dietary risk assessments were
conducted using the Dietary Exposure Evaluation Model (DEEM-FCID(,
Version 2.03), which uses food consumption data from the USDA’s
Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996
and 1998.    SEQ CHAPTER \h \r 1 

Acute (Food and Drinking Water) Dietary Exposure Results and
Characterization

An acute dietary analysis was conducted for dimethenamid-p, assuming
tolerance level residues, default processing factors, and 100 percent
crop treated (%CT) information.  The highest drinking water estimate for
acute exposure, 66.7 ppb, was used in the analysis.  There was only one
acute toxicological endpoint selected for the population subgroup
females 13-49.  The risk estimate due to acute dietary exposure from
food and water for this population subgroup is less than 1% of the aPAD,
which is below ARIA’s level of concern.  

Chronic (Food and Drinking Water) Dietary Exposure Results and
Characterization

A chronic dietary analysis was conducted for dimethenamid-p, assuming
tolerance level residues, default processing factors, and 100% CT
information.  The highest drinking water estimate for chronic exposure,
20.2 ppb, was used in the analysis.  The highest risk estimates due to
chronic dietary exposure from food and water was reported for all
infants (<1 year old) at <3% of the cPAD, which is below ARIA’s level
of concern.  

Cancer Dietary Exposure Results and Characterization

Dimethenamid-p is a category “C” possible human carcinogen;
therefore, quantification of human cancer risk is not required and a
cancer dietary assessment was not performed.

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which ARIA has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL,
e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, ARIA is concerned when
estimated dietary risk exceeds 100% of the PAD.  References which
discuss the acute and chronic risk assessments in more detail are
available on the EPA/pesticides web site:  “Available Information on
Assessing Exposure from Pesticides, A User’s Guide,” 21/JUN/2000,
web link: 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see
SOP 99.6 (8/20/1999).

The most recent dietary risk assessment for dimethenamid-p was conducted
by Debra Rate (DP#: 337886, 4/12/2007) for use on grasses grown for
seed.

II.	Residue Information

Dimethenamid-p Use:  In this analysis the acute and chronic dietary
exposure and risk estimates resulting from food intake were determined
for the general U.S. population and various population subgroups
resulting from the addition of winter squash, pumpkin, radish (roots and
tops), rutabaga (roots and tops), turnip (roots, tops and greens) and
hops, dried cones, to the existing food uses for dimethenamid-p.

Dimethenamid-P, which is a form of dimethenamid that is enriched in the
biologically active S-isomer (90:10, S:R), is a selective, preemergence
herbicide registered for the control of annual broadleaf and grass weeds
in a variety of field and vegetable crops.  Tolerances are established
for residues of dimethenamid,
(RS)-2-chloro-N-[(1-methyl-2-methoxy)ethyl]-N-(2,4-dimethylthien-3-yl)ac
etamide, in/on numerous raw agricultural commodities at 0.01 ppm, which
is the lowest limit of method validation.  Tolerances are established in
40 CFR §180.464(a) and (b) for both dimethenamid (50:50, S:R) and
dimethenamid-P (90:10, S:R).  As a result, tolerances that are
established for the proposed commodities will apply to both dimethenamid
and dimethenamid-P.  Tolerances for residues of dimethenamid in animal
commodities have not been established. 

The residue of concern for enforcement and risk assessment purposes is
dimethenamid per se. 

Residue Data Used for Acute and Chronic Assessments:  The following
conservative assumptions were made for the acute and chronic dietary
analysis:  ARIA recommended tolerance level residues (associated with
the current petition and previously registered uses), DEEM( default
processing factors and assumed 100% CT with dimethenamid-p for all
commodities.   Recommended tolerance levels for the current petition
were provided by ARIA (D. Rate, DP#: 341886, 9/25/2007).

As part of the current petition, ARIA recommends establishing permanent
tolerances for residues of dimethenamid at 0.01 ppm on radish roots and
tops, turnip roots, rutabaga roots, pumpkins and winter squash. 
Tolerances should also be established at 0.1 ppm on turnip tops and
rutabaga tops, and at 0.05 ppm on hops, dried cones.  

It should be noted that the data submitted for radish, turnip and
rutabaga, while adequate for individual crop tolerances, are not
sufficient for a crop group tolerance.  All of the recommended
tolerances should be placed in 40 CFR §180.464(a), without restriction,
except for the tolerances for pumpkins and winter squash which should be
placed in 40 CFR §180.464(c), as the use on these crops is restricted
to OR and WA.  The data submitted for hops support a national tolerance
placing it in 40 CFR §180.464(a), even though the labeled use submitted
by the petitioner restricts distribution to ID, OR and WA (>95% of US
hops production). 

  

III.  	Drinking Water Data

The drinking water residues used in the dietary risk assessment were
provided by EFED and summarized in the following memoranda: “Drinking
Water Exposure Assessment for the Section 3 IR-4 Proposed New Uses of
S-Dimethenamid on Squash, Pumpkin, Rutabaga, Turnip, Radish and Hops.”
(P. Mastradone, 8/28/2007) and incorporated directly into this dietary
assessment.  Water residues were incorporated in the DEEM-FCID into the
food categories “water, direct, all sources” and “water, indirect,
all sources.” 

Considering all currently registered uses as well as the proposed new
uses, the highest acute estimated drinking water concentration (EDWC) is
from the green onion use (66.7 ppb) while the highest chronic EDWC is
from the ornamental use (20.2 ppb), as presented in Table 1.  

Table 1.  Maximum EDWC’S (ppb) from all Current and Proposed Uses of
S-Dimethenamid.

Use	Surface Water a	Ground Water b

	Modeled scenario c

(App. Method)	Acute

[1-in-10 year peak]	Chronic

[1-in-10 year average]	Acute and Chronic

Green Onions	GA onion

(Ground spray)	66.7	8.4	0.34

Ornamentals	FL turf – Acute

OR xmas - Chronic

(Aerial spray)	50.2	20.2	1.0

a Generated using Tier 2 linked simulation models Pesticide Root Zone
Model (PRZM) (3.12beta) / Exposure Analysis Modeling System (EXAMS)
(2.98.04).

b Generated using Tier 1 model SCIGROW (2.3).

c Only the uses, scenarios, and application methods with the highest
EDWCs are presented here.  As appropriate, other uses and scenarios were
modeled for characterization and are discussed in the drinking water
memo.

M-FCID™ Program and Consumption Information

Dimethenamid-p acute and chronic dietary exposure assessments were
conducted using the Dietary Exposure Evaluation Model software with the
Food Commodity Intake Database (DEEM-FCID™, Version 2.03), which
incorporates consumption data from USDA’s Continuing Surveys of Food
Intakes by Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98
data are based on the reported consumption of more than 20,000
individuals over two non-consecutive survey days.  Foods “as
consumed” (e.g., apple pie) are linked to EPA-defined food commodities
(e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicly available recipe
translation files developed jointly by USDA/ARS and EPA.  For chronic
exposure assessment, consumption data are averaged for the entire U.S.
population and within population subgroups, but for acute exposure
assessment are retained as individual consumption events.  Based on
analysis of the 1994-96, 98 CSFII consumption data, which took into
account dietary patterns and survey respondents, HED concluded that it
is most appropriate to report risk for the following population
subgroups: the general U.S. population, all infants (<1 year old),
children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49,
females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., only those who reported
eating relevant commodities/food forms) and a per-capita (i.e., those
who reported eating the relevant commodities as well as those who did
not) basis.  In accordance with HED policy, per capita exposure and risk
are reported for all tiers of analysis.  However, for tiers 1 and 2, any
significant differences in user vs. per capita exposure and risk are
specifically identified and noted in the risk assessment.

V.	Toxicological Information

FQPA safety factor (SF):  Based on the hazard data, HED recommended the
FQPA SF be reduced to 1X because there are low concerns, and no residual
uncertainties with regard to pre- and/or postnatal toxicity.  Also,
based on the quality of the exposure data, the dimethenamid-p risk
assessment team recommended that the FQPA SF be reduced to 1X.

Acute Dietary Exposure:  The acute no observable adverse effect level
(NOAEL) is 75 mg/kg/day.  The acute lowest observable adverse effect
level (LOAEL) is 150 mg/kg/day based on developmental effects of
increased resorptions, implantation loss and angulated hyoid alae.  The
resorptions and post implantation loss is presumed to be a single dose
effect.  The developmental endpoint is appropriate for females 13-49 and
is of the appropriate duration.  The endpoint is supported by a
range-finding study in rats with [S]-dimethenamid, which showed
increased resorptions at 400 mg/kg/day.

An appropriate acute endpoint attributable to a single dose was not
identified for the general population in the toxicity data base
including the developmental toxicity studies.   

Chronic Dietary Exposure:  The chronic NOAEL is 5.1/6.8 mg/kg/day for
male/female.  The chronic LOAEL is 36/49 mg/kg/day for male/female based
on decreased body weight and body weight gain from week 1-10 and week
10-104 in both sexes, and at termination increased microscopic hepatic
lesions in both sexes. 

Table 2.  Summary of Toxicological Dose and Endpoints for
Dimethenamid-p for Use in Dietary Exposure Assessment.

Exposure

Scenario	

Dose Used in Risk Assessment, UF 	

FQPA SF and Level of Concern for Risk Assessment	

Study and Toxicological Effects

Acute Dietary

(Females 13-49 years of age)

Based on [R,S] data	

NOAEL = 75 mg/kg/day

UF = 100

Acute RfD = 0.75 mg/kg/day	

FQPA SF = 1X

aPAD = acute RfD

              FQPA SF

= 0.75 mg/kg/day	

Developmental Toxicity in rabbits

Maternal LOAEL = 150 mg/kg/day based on abortions and decreased body
weight gain and food consumption.

Developmental; LOAEL = 150 mg/kg/day based on post-implantation loss

Acute Dietary

(General population including infants and children)	

Not Applicable

No studies identify an acute hazard (dose and endpoint) based on a
single oral exposure (dose) 		

Chronic Dietary

(All populations)

Based on [R,S] data	

NOAEL= 5 mg/kg/day

UF = 100 

Chronic RfD = 

0.05 mg/kg/day

	

FQPA SF = 1X  

cPAD = 

chronic RfD

 FQPA SF

=  0.05 mg/kg/day	

Chronic/carcinogenicity rats

LOAEL = M/F; 36/49 mg/kg/day based on decreased body weight and body
weight gain in both sexes, increased food conversion ratios in females,
and increased microscopic hepatic lesions in both sexes. 

Carcinogenicity

Based on [R,S] data 	

“C” Possible human carcinogen.  (No Q1*)   

[R,S] = a 50:50 racemic mixture of [R]-dimethenamid and
[S]-dimethenamid.  Dimethenamid-p is enriched for the [S]-isomer at a
ratio of 90:10 (S:R).

VI.	Results/Discussion

For acute and chronic assessments, ARIA is concerned when dietary risk
exceeds 100% of the PAD.  The DEEM-FCID( analyses estimate the dietary
exposure of the U.S. population and various population subgroups.  The
results reported are for the general U.S. population, all infants (<1
year old), children 1-2, children 3-5, children 6-12, youth 13-19,
females 13-49, adults 20-49, and adults 50+ years.  

Results of Acute Dietary Exposure Analysis

The acute dietary exposure for food and surface water utilized <1% of
the aPAD for females 13-49 years old at the 95th percentile.  There were
no appropriate toxicological effects attributable to a single exposure
(dose) for the general population or any other population subgroups;
therefore these population subgroups were not included in this
assessment.

Table 3.  Results of Acute Dietary Exposure Analysis at the 95th
Percentile of Exposure.

Population Subgroup	

aPAD

(mg/kg/day)	

Exposure (mg/kg/day)	

% aPAD

Females 13-49	

0.75	0.003285	<1

Results of Chronic Dietary Exposure Analysis

The chronic dietary exposure for food and surface water utilized <1% of
the cPAD for the U.S. population.  The chronic dietary exposure for the
highest reported exposed population subgroup, all infants (<1 year old),
was <3% of the cPAD.

Table 4.  Results of Chronic Dietary Exposure Analysis.

Population Subgroup	cPAD

(mg/kg/day)	Exposure (mg/kg/day)	% cPAD

General U.S. Population	

0.05	0.000471	<1

All Infants (< 1 year old)

0.001460	3

Children 1-2 years old

0.000728	2

Children 3-5 years old

0.000692	1

Children 6-12 years old

0.000480	1

Youth 13-19 years old

0.000359	<1

Adults 20-49 years old

0.000434	<1

Adults 50+ years old

0.000447	<1

Females 13-49 years old

0.000431	<1

Results of Cancer Dietary Exposure Analysis

Dimethenamid is a category “C” possible human carcinogen not
requiring any type of quantitative cancer risk assessment.

These analyses are highly conservative dietary exposure assessments. 
Further refinement to the analyses could be made through the use of
anticipated residues, incorporation of percentages of crops treated with
dimethenamid-p, processing factors and/or monitoring data that better
reflect residues at the time of consumption.  Since risk estimates are
below ARIA’s level of concern, a more highly refined analysis is not
needed at this time.

VII.	Conclusions

Acute and chronic dietary (food and drinking water) exposure assessments
were conducted for the proposed and existing uses of dimethenamid-p.  

The acute dietary (food + drinking water) exposure to dimethenamid-p is
below ARIA’s level of concern for the females 13-49 years old
population subgroup. The acute dietary exposure for food and surface
water utilized <1% of the aPAD at the 95th percentile for females 13-49
years old.  

The chronic dietary (food + drinking water) exposure to dimethenamid-p
is below ARIA’s level of concern for the general U.S. population and
all population subgroups.  The chronic dietary exposure utilized <1% of
the cPAD for the general U.S. population and 3% of the cPAD for all
infants (<1 year old), the most highly exposed population subgroup. 

VIII.		List of Attachments

Attachment 1:  Acute Food plus Water Residue Input File

Attachment 2:  Acute Results File

Attachment 3:  Chronic Food plus Water Residue Input File

Attachment 4:  Chronic Results File

cc: S. Brothers

Attachment 1:  Acute Food plus Water Residue Input File

U.S. Environmental Protection Agency                                
Ver. 2.02

DEEM-FCID Acute analysis for DIMETHENAMIDE

Residue file name: C:\Documents and Settings\bhanson\My
Documents\Breann's Work\ARIA\Dimethenamide-P\Finals\120051a.R98

Analysis Date 09-17-2007             Residue file dated:
07-25-2007/11:54:10/8

Reference dose (aRfD) = 0.75 mg/kg bw/day

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Food Name                         (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

01030150 1CD  Arrowroot, flour                   0.010000   1.000  1.000

01030151 1CD  Arrowroot, flour-babyfood          0.010000   1.000  1.000

01030170 1CD  Artichoke, Jerusalem               0.010000   1.000  1.000

06030300 6C   Bean, black, seed                  0.010000   1.000  1.000

06030320 6C   Bean, broad, seed                  0.010000   1.000  1.000

06030340 6C   Bean, cowpea, seed                 0.010000   1.000  1.000

06030350 6C   Bean,  great northern, seed        0.010000   1.000  1.000

06030360 6C   Bean, kidney, seed                 0.010000   1.000  1.000

06030380 6C   Bean, lima, seed                   0.010000   1.000  1.000

06030390 6C   Bean, mung, seed                   0.010000   1.000  1.000

06030400 6C   Bean, navy, seed                   0.010000   1.000  1.000

06030410 6C   Bean, pink, seed                   0.010000   1.000  1.000

06030420 6C   Bean, pinto, seed                  0.010000   1.000  1.000

01010500 1AB  Beet, garden, roots                0.010000   1.000  1.000

01010501 1AB  Beet, garden, roots-babyfood       0.010000   1.000  1.000

02000510 2    Beet, garden, tops                 0.010000   1.000  1.000

01010520 1A   Beet, sugar                        0.010000   1.000  1.000

01010521 1A   Beet, sugar-babyfood               0.010000   1.000  1.000

01010530 1A   Beet, sugar, molasses              0.010000   1.000  1.000

01010531 1A   Beet, sugar, molasses-babyfood     0.010000   1.000  1.000

01030820 1CD  Cassava                            0.010000   1.000  1.000

01030821 1CD  Cassava-babyfood                   0.010000   1.000  1.000

06030980 6C   Chickpea, seed                     0.010000   1.000  1.000

06030981 6C   Chickpea, seed-babyfood            0.010000   1.000  1.000

06030990 6C   Chickpea, flour                    0.010000   1.000  1.000

15001200 15   Corn, field, flour                 0.010000   1.000  1.000

15001201 15   Corn, field, flour-babyfood        0.010000   1.000  1.000

15001210 15   Corn, field, meal                  0.010000   1.000  1.000

15001211 15   Corn, field, meal-babyfood         0.010000   1.000  1.000

15001220 15   Corn, field, bran                  0.010000   1.000  1.000

15001230 15   Corn, field, starch                0.010000   1.000  1.000

15001231 15   Corn, field, starch-babyfood       0.010000   1.000  1.000

15001240 15   Corn, field, syrup                 0.010000   1.500  1.000

15001241 15   Corn, field, syrup-babyfood        0.010000   1.500  1.000

15001250 15   Corn, field, oil                   0.010000   1.000  1.000

15001251 15   Corn, field, oil-babyfood          0.010000   1.000  1.000

15001260 15   Corn, pop                          0.010000   1.000  1.000

15001270 15   Corn, sweet                        0.010000   1.000  1.000

15001271 15   Corn, sweet-babyfood               0.010000   1.000  1.000

01031390 1CD  Dasheen, corm                      0.010000   1.000  1.000

02001400 2    Dasheen, leaves                    0.010000   1.000  1.000

03001640 3    Garlic                             0.010000   1.000  1.000

03001650 3    Garlic, dried                      0.010000   1.000  1.000

03001651 3    Garlic, dried-babyfood             0.010000   1.000  1.000

01031660 1CD  Ginger                             0.010000   1.000  1.000

01031661 1CD  Ginger-babyfood                    0.010000   1.000  1.000

01031670 1CD  Ginger, dried                      0.010000   1.000  1.000

95001880 O    Hop                                0.050000   1.000  1.000

01011900 1AB  Horseradish                        0.010000   1.000  1.000

03001980 3    Leek                               0.010000   1.000  1.000

03002370 3    Onion, dry bulb                    0.010000   1.000  1.000

03002371 3    Onion, dry bulb-babyfood           0.010000   1.000  1.000

03002380 3    Onion, dry bulb, dried             0.010000   9.000  1.000

03002381 3    Onion, dry bulb, dried-babyfood    0.010000   9.000  1.000

03002390 3    Onion, green                       0.010000   1.000  1.000

95002630 O    Peanut                             0.010000   1.000  1.000

95002640 O    Peanut, butter                     0.010000   1.890  1.000

95002650 O    Peanut, oil                        0.010000   1.000  1.000

01032960 1C   Potato, chips                      0.010000   1.000  1.000

01032970 1C   Potato, dry (granules/ flakes)     0.010000   6.500  1.000

01032971 1C   Potato, dry (granules/ flakes)-b   0.010000   6.500  1.000

01032980 1C   Potato, flour                      0.010000   1.000  1.000

01032981 1C   Potato, flour-babyfood             0.010000   1.000  1.000

01032990 1C   Potato, tuber, w/peel              0.010000   1.000  1.000

01032991 1C   Potato, tuber, w/peel-babyfood     0.010000   1.000  1.000

01033000 1C   Potato, tuber, w/o peel            0.010000   1.000  1.000

01033001 1C   Potato, tuber, w/o peel-babyfood   0.010000   1.000  1.000

09023080 9B   Pumpkin                            0.010000   1.000  1.000

09023090 9B   Pumpkin, seed                      0.010000   1.000  1.000

01013140 1AB  Radish, roots                      0.010000   1.000  1.000

02003150 2    Radish, tops                       0.010000   1.000  1.000

01013270 1AB  Rutabaga                           0.010000   1.000  1.000

03003380 3    Shallot                            0.010000   1.000  1.000

15003440 15   Sorghum, grain                     0.010000   1.000  1.000

06003470 6    Soybean, seed                      0.010000   1.000  1.000

06003480 6    Soybean, flour                     0.010000   1.000  1.000

06003481 6    Soybean, flour-babyfood            0.010000   1.000  1.000

06003490 6    Soybean, soy milk                  0.010000   1.000  1.000

06003491 6    Soybean, soy milk-babyfood or in   0.010000   1.000  1.000

06003500 6    Soybean, oil                       0.010000   1.000  1.000

06003501 6    Soybean, oil-babyfood              0.010000   1.000  1.000

09023570 9B   Squash, winter                     0.010000   1.000  1.000

09023571 9B   Squash, winter-babyfood            0.010000   1.000  1.000

01033660 1CD  Sweet potato                       0.010000   1.000  1.000

01033661 1CD  Sweet potato-babyfood              0.010000   1.000  1.000

01033710 1CD  Tanier, corm                       0.010000   1.000  1.000

01033870 1CD  Turmeric                           0.010000   1.000  1.000

01013880 1AB  Turnip, roots                      0.010000   1.000  1.000

05023890 5B   Turnip, greens                     0.100000   1.000  1.000

86010000 O    Water, direct, all sources         0.066700   1.000  1.000

86020000 O    Water, indirect, all sources       0.066700   1.000  1.000

01034060 1CD  Yam, true                          0.010000   1.000  1.000

01034070 1CD  Yam bean                           0.010000   1.000  1.000

 Attachment 2:  Acute Results File



U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for DIMETHENAMIDE                      
(1994-98 data)

Residue file: 120051a.R98                         Adjustment factor #2
NOT used.

Analysis Date: 09-17-2007/15:29:50    Residue file dated:
07-25-2007/11:54:10/8

Daily totals for food and foodform consumption used.

Run Comment: ""

========================================================================
=======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
--------

Females 13-49 yrs:

                    0.003285     0.44    0.005250     0.70    0.009310  
  1.24 

Attachment 3:  Chronic Food plus Water Residue Input File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for DIMETHENAMIDE                     
1994-98 data

Residue file: C:\Documents and Settings\bhanson\My Documents\Breann's
Work\ARIA\Dimethenamide-P\Finals\120051c.R98

                                                           Adjust. #2
NOT used

Analysis Date 09-17-2007             Residue file dated:
07-25-2007/11:56:44/8

Reference dose (RfD) = 0.05 mg/kg bw/day

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

01030150 1CD  Arrowroot, flour                   0.010000   1.000     
1.000   

01030151 1CD  Arrowroot, flour-babyfood          0.010000   1.000     
1.000   

01030170 1CD  Artichoke, Jerusalem               0.010000   1.000     
1.000   

06030300 6C   Bean, black, seed                  0.010000   1.000     
1.000   

06030320 6C   Bean, broad, seed                  0.010000   1.000     
1.000   

06030340 6C   Bean, cowpea, seed                 0.010000   1.000     
1.000   

06030350 6C   Bean,  great northern, seed        0.010000   1.000     
1.000   

06030360 6C   Bean, kidney, seed                 0.010000   1.000     
1.000   

06030380 6C   Bean, lima, seed                   0.010000   1.000     
1.000   

06030390 6C   Bean, mung, seed                   0.010000   1.000     
1.000   

06030400 6C   Bean, navy, seed                   0.010000   1.000     
1.000   

06030410 6C   Bean, pink, seed                   0.010000   1.000     
1.000   

06030420 6C   Bean, pinto, seed                  0.010000   1.000     
1.000   

01010500 1AB  Beet, garden, roots                0.010000   1.000     
1.000   

01010501 1AB  Beet, garden, roots-babyfood       0.010000   1.000     
1.000   

02000510 2    Beet, garden, tops                 0.010000   1.000     
1.000   

01010520 1A   Beet, sugar                        0.010000   1.000     
1.000   

01010521 1A   Beet, sugar-babyfood               0.010000   1.000     
1.000   

01010530 1A   Beet, sugar, molasses              0.010000   1.000     
1.000   

01010531 1A   Beet, sugar, molasses-babyfood     0.010000   1.000     
1.000   

01030820 1CD  Cassava                            0.010000   1.000     
1.000   

01030821 1CD  Cassava-babyfood                   0.010000   1.000     
1.000   

06030980 6C   Chickpea, seed                     0.010000   1.000     
1.000   

06030981 6C   Chickpea, seed-babyfood            0.010000   1.000     
1.000   

06030990 6C   Chickpea, flour                    0.010000   1.000     
1.000   

15001200 15   Corn, field, flour                 0.010000   1.000     
1.000   

15001201 15   Corn, field, flour-babyfood        0.010000   1.000     
1.000   

15001210 15   Corn, field, meal                  0.010000   1.000     
1.000   

15001211 15   Corn, field, meal-babyfood         0.010000   1.000     
1.000   

15001220 15   Corn, field, bran                  0.010000   1.000     
1.000   

15001230 15   Corn, field, starch                0.010000   1.000     
1.000   

15001231 15   Corn, field, starch-babyfood       0.010000   1.000     
1.000   

15001240 15   Corn, field, syrup                 0.010000   1.500     
1.000   

15001241 15   Corn, field, syrup-babyfood        0.010000   1.500     
1.000   

15001250 15   Corn, field, oil                   0.010000   1.000     
1.000   

15001251 15   Corn, field, oil-babyfood          0.010000   1.000     
1.000   

15001260 15   Corn, pop                          0.010000   1.000     
1.000   

15001270 15   Corn, sweet                        0.010000   1.000     
1.000   

15001271 15   Corn, sweet-babyfood               0.010000   1.000     
1.000   

01031390 1CD  Dasheen, corm                      0.010000   1.000     
1.000   

02001400 2    Dasheen, leaves                    0.010000   1.000     
1.000   

03001640 3    Garlic                             0.010000   1.000     
1.000   

03001650 3    Garlic, dried                      0.010000   1.000     
1.000   

03001651 3    Garlic, dried-babyfood             0.010000   1.000     
1.000   

01031660 1CD  Ginger                             0.010000   1.000     
1.000   

01031661 1CD  Ginger-babyfood                    0.010000   1.000     
1.000   

01031670 1CD  Ginger, dried                      0.010000   1.000     
1.000   

95001880 O    Hop                                0.050000   1.000     
1.000   

01011900 1AB  Horseradish                        0.010000   1.000     
1.000   

03001980 3    Leek                               0.010000   1.000     
1.000   

03002370 3    Onion, dry bulb                    0.010000   1.000     
1.000   

03002371 3    Onion, dry bulb-babyfood           0.010000   1.000     
1.000   

03002380 3    Onion, dry bulb, dried             0.010000   9.000     
1.000   

03002381 3    Onion, dry bulb, dried-babyfood    0.010000   9.000     
1.000   

03002390 3    Onion, green                       0.010000   1.000     
1.000   

95002630 O    Peanut                             0.010000   1.000     
1.000   

95002640 O    Peanut, butter                     0.010000   1.890     
1.000   

95002650 O    Peanut, oil                        0.010000   1.000     
1.000   

01032960 1C   Potato, chips                      0.010000   1.000     
1.000   

01032970 1C   Potato, dry (granules/ flakes)     0.010000   6.500     
1.000   

01032971 1C   Potato, dry (granules/ flakes)-b   0.010000   6.500     
1.000   

01032980 1C   Potato, flour                      0.010000   1.000     
1.000   

01032981 1C   Potato, flour-babyfood             0.010000   1.000     
1.000   

01032990 1C   Potato, tuber, w/peel              0.010000   1.000     
1.000   

01032991 1C   Potato, tuber, w/peel-babyfood     0.010000   1.000     
1.000   

01033000 1C   Potato, tuber, w/o peel            0.010000   1.000     
1.000   

01033001 1C   Potato, tuber, w/o peel-babyfood   0.010000   1.000     
1.000   

09023080 9B   Pumpkin                            0.010000   1.000     
1.000   

09023090 9B   Pumpkin, seed                      0.010000   1.000     
1.000   

01013140 1AB  Radish, roots                      0.010000   1.000     
1.000   

02003150 2    Radish, tops                       0.010000   1.000     
1.000   

01013270 1AB  Rutabaga                           0.010000   1.000     
1.000   

03003380 3    Shallot                            0.010000   1.000     
1.000   

15003440 15   Sorghum, grain                     0.010000   1.000     
1.000   

06003470 6    Soybean, seed                      0.010000   1.000     
1.000   

06003480 6    Soybean, flour                     0.010000   1.000     
1.000   

06003481 6    Soybean, flour-babyfood            0.010000   1.000     
1.000   

06003490 6    Soybean, soy milk                  0.010000   1.000     
1.000   

06003491 6    Soybean, soy milk-babyfood or in   0.010000   1.000     
1.000   

06003500 6    Soybean, oil                       0.010000   1.000     
1.000   

06003501 6    Soybean, oil-babyfood              0.010000   1.000     
1.000   

09023570 9B   Squash, winter                     0.010000   1.000     
1.000   

09023571 9B   Squash, winter-babyfood            0.010000   1.000     
1.000   

01033660 1CD  Sweet potato                       0.010000   1.000     
1.000   

01033661 1CD  Sweet potato-babyfood              0.010000   1.000     
1.000   

01033710 1CD  Tanier, corm                       0.010000   1.000     
1.000   

01033870 1CD  Turmeric                           0.010000   1.000     
1.000   

01013880 1AB  Turnip, roots                      0.010000   1.000     
1.000   

05023890 5B   Turnip, greens                     0.100000   1.000     
1.000   

86010000 O    Water, direct, all sources         0.020200   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.020200   1.000     
1.000   

01034060 1CD  Yam, true                          0.010000   1.000     
1.000   

01034070 1CD  Yam bean                           0.010000   1.000     
1.000   

Attachment 4:  Chronic Results File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for DIMETHENAMIDE                    (1994-98
data)

Residue file name: C:\Documents and Settings\bhanson\My
Documents\Breann's Work\ARIA\Dimethenamide-P\Finals\120051c.R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 09-17-2007/15:32:52     Residue file dated:
07-25-2007/11:56:44/8

Reference dose (RfD, Chronic) = .05 mg/kg bw/day

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.000471                
0.9%

U.S. Population (spring season)             0.000467                
0.9%

U.S. Population (summer season)             0.000503                
1.0%

U.S. Population (autumn season)             0.000456                
0.9%

U.S. Population (winter season)             0.000455                
0.9%

Northeast region                            0.000428                
0.9%

Midwest region                              0.000479                
1.0%

Southern region                             0.000450                
0.9%

Western region                              0.000532                
1.1%

Hispanics                                   0.000533                
1.1%

Non-hispanic whites                         0.000459                
0.9%

Non-hispanic blacks                         0.000454                
0.9%

Non-hisp/non-white/non-black                0.000564                
1.1%

All infants (< 1 year)                      0.001460                
2.9%

Nursing infants                             0.000542                
1.1%

Non-nursing infants                         0.001808                
3.6%

Children 1-6  yrs                           0.000691                
1.4%

Children 7-12 yrs                           0.000456                
0.9%

Females 13-19 (not preg or nursing)         0.000344                
0.7%

Females 20+ (not preg or nursing)           0.000455                
0.9%

Females 13-50 yrs                           0.000450                
0.9%

Females 13+ (preg/not nursing)              0.000450                
0.9%

Females 13+ (nursing)                       0.000627                
1.3%

Males 13-19 yrs                             0.000371                
0.7%

Males 20+ yrs                               0.000418                
0.8%

Seniors 55+                                 0.000446                
0.9%

Children 1-2 yrs                            0.000728                
1.5%

Children 3-5 yrs                            0.000692                
1.4%

Children 6-12 yrs                           0.000480                
1.0%

Youth 13-19 yrs                             0.000359                
0.7%

Adults 20-49 yrs                            0.000434                
0.9%

Adults 50+ yrs                              0.000447                
0.9%

Females 13-49 yrs                           0.000431                
0.9%

Dimethenamid-p	Dietary Exposure Assessment	DP Num:	337886

PC Code: 129051 and 120051		Page:   PAGE  1  of 14

Dimethenamid-p	Dietary Exposure Assessment	DP Num:	337886

PC Code: 129051		Page:   PAGE  8  of 14

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ऀDimethenamid-p	Dietary Exposure Assessment	DP Num:	337886

PC Code: 129051		Page:   PAGE  15  of 14