Document ID: EPA-HQ-OPP-2007-0637-0007
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2008-02-13T05:00Z

SEQ CHAPTER \h \r 1 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF              

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES 

MEMORANDUM

DATE:  	10-June-2007  

SUBJECT:	1,3-Dichloropropene Chronic and Cancer Aggregate Dietary Food
and Drinking Water Exposure and Risk Assessments for the Proposed New
Use in Grape Vineyards

PC Code:	029001			Decision Number:  217283

DP Number:	D340060

REVIEWER:	Christine L. Olinger, Chemist

Reregistration Branch 1

Health Effects Division (7509P)

THROUGH:	Sheila Piper, Chemist

Anant Parmar, Biologist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P)

and

Michael S. Metzger, Chief

Reregistration Branch 1

Health Effects Division (7509P)

DEEM-FCID™, Version 2.03, which uses food consumption data from the
U.S. Department of Agriculture’s Continuing Surveys of Food Intakes by
Individuals (CSFII) from 1994-1996 and 1998.  The analyses were
performed to support a Section 3 request to apply 1,3-dichloropropene
via drip irrigation to established vineyards.  This is the first food
use for this active ingredient.  The existing pre-plant field fumigation
uses are considered to be non-food uses.

1,3-Dichloropropene (1,3-D) formulations contain approximately equal
amounts of the cis  and trans isomers.  The residues of concern in food,
which are also degradates of concern in drinking water, are the cis and
trans isomers of 3-chloroacrylic acid and 3-chloroallyl alcohol.  The
degradates are assumed to have equal toxicity as the parent.  Separate
toxicity endpoints have been selected for the formulation contaminant
1,2-dichloropropane, a residue of concern in drinking water.  An acute
dietary assessment was not required as no hazard was identified.

Chronic Dietary Exposure Results and Characterization

Residues of five of the six residues of concern in grape commodities are
expected to be non-detectable, with the remaining residue to be at or
below the limit of quantitation.  Anticipated residues were calculated
for grape commodities were calculated by adding ½ the limit of
detection for five of the residues to the limit of quantitation of the
remaining residue. It was assumed that all crops in the US are treated. 
Estimated drinking water concentrations are based on a combination of
monitoring and modeling.  The dietary exposure is less than 1% of the
population adjusted dose for all population groups for food alone and
food plus tap water from ground water sources, and is less than 5% of
the population adjusted dose for all population groups for food plus
water from surface water sources.  The most highly exposed sub-group is
infants, if the surface water value is used, and children aged 1-2 if
the tap water value is used. 

Cancer Dietary Exposure Results and Characterization

The same food and water concentrations were used in the cancer
assessment as in the chronic assessment.  Cancer dietary exposure
analyses were conducted for the combined residues of parent and
degradates as well as separate analyses for the formulation contaminant
1,2-dichloropropane.  The cancer risk for the combined residues of
parent and degradates is below the level of concern for food exposure
and food plus drinking water, when the tap water monitoring data are
used for the estimated drinking water concentrations.  The cancer risk
exceeds the level of concern when the drinking water concentrations are
estimated from models or targeted monitoring studies in high use areas,
where water is sampled in the field.  Although these risks exceed the
level of concern, tap water monitoring studies in high use areas show
much lower water concentrations than modeling or targeted monitoring in
the field.  Accordingly if comparable tap water monitoring were
available, HED believes the risks would be below the level of concern.

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL,
e.g.) divided by the required uncertainty or safety factors.

For non-cancer chronic exposures, HED is concerned when estimated
dietary risk exceeds 100% of the PAD.  HED is generally concerned when
estimated cancer risk exceeds one in one million. References which
discuss the acute and chronic risk assessments in more detail are
available on the EPA/pesticides web site:  “Available Information on
Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000,
web link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see
SOP 99.6 (20-AUG-1999).

The previous dietary risk assessment addressed drinking water exposure
only and may be found in the most recent version of the human health
chapter to the Reregistration Eligibility Decision Document (D. Vogel,
4/12/07, D337328)

II.	Residue Information

Tolerances have not been established for 1,3-dichloropropene (1,3-D),
which is currently registered for pre-plant fumigations on numerous
crops.  1,3-D is readily degraded and incorporated into natural
constituents, so the pre-plant uses are considered to be non-food uses. 
The registrant is proposing an in-season use of 1,3-D using drip
irrigation in established vineyards at rates considerably lower than
existing application rates.

The residues of concern in food and water are the cis and trans isomers
of the parent compound, and the cis and trans isomers of 3-chloroacrylic
acid (CAAC) and 3-chloroallyl alcohol (CAAL) (C. Olinger, D340059,
6/7/2007).  

Residue Data used for Chronic and Cancer Assessments:

Residues of the parent isomers and three of the four degradates are
expected to be non-detectable at harvest at a detection limit (LOD) of 1
ppb.  In one of the thirteen trials conducted residues of one degradate
were at the limit of quantitation (LOQ) in exaggerated rate field
trials.  Therefore, for all grape commodities an anticipated residue was
calculated by adding ½ the LOD for each of the non-detectable analytes
(cis-1,3-D, trans-1,3-D, cis-CAAC, trans-CAAC, and trans-CAAL) to the
LOQ for the remaining analyte, cis-CAAL, for a total of 0.0055 ppm, as
described in Table 1 below.  No processing factors were used.  Due to
very low residues detected and the highly volatile nature of 1,3-D,
concentration of residues in processed commodities is not expected and
processing studies were not required (C. Olinger, 5/24/07, D318734).  It
was assumed that all crops were treated in this assessment.

Table 1.  Summary of Anticipated Residues Used for All Grape
Commodities, Chronic and Cancer Exposures

Analyte	Anticipated Residue, ppm	Description

cis-1,3-Dichloropropene	0.0005	½ Limit of Detection

trans-1,3-Dichloropropene	0.0005	½ Limit of Detection

cis-3-Chloroacrylic acid	0.0005	½ Limit of Detection

trans-3-Chloroacrylic acid	0.0005	½ Limit of Detection

cis-3-Chloroallyl alcohol	0.003	Limit of Quantitation

trans-3-Chloroallyl alcohol	0.0005	½ Limit of Detection

Total Residues	0.0055	--

 Drinking Water Data

The drinking water residues used in the dietary risk assessment were
provided by the Environmental Fate and Effects Division (EFED) in the
following memorandum (W. Eckel, 6/26/00; D260209 and D260210) and
incorporated directly into this dietary assessment.  The residues of
concern in water are the cis and trans isomers of the parent compound,
and the cis and trans isomers of 3-chloroacrylic acid (CAAC) and
3-chloroallyl alcohol (CAAL).  Additionally, the formulation contaminant
1,2-dichloropropane is also of concern in drinking water.

The estimated drinking water concentrations (EDWC) are presented in
Table 2.  A combination of modeling and monitoring data were used.  The
EDWC for groundwater was obtained from a tap water monitoring study from
areas where 1,3-D is used as a pre-plant fumigant was used.  PRZM/EXAMS
modeling was used to generate the surface water EDWC for the parent and
degradates.  Monitoring data were used for both the surface and ground
water estimates for 1,2-dichloropropane.  The water residues were
incorporated in the DEEM-FCID into the food categories “water, direct,
all sources” and “water, indirect, all sources.”  The model and
its description are available at the EPA internet site:   HYPERLINK
"http://www.epa.gov/oppefed1/models/water/" 
http://www.epa.gov/oppefed1/models/water/ .  

Table 2. Estimated Drinking Water Concentrations for 1,3-D in Surface
Water and Groundwater

Chemical	Surface Water (μg/L)	Groundwater  (μg/L)

	Cancer/chronic	Cancer/chronic

1,3-D and Degradates 3	16.2 1	0.14 2

1,2-Dichloropropane (Contaminant)	8.9	3.97

1 Estimated drinking water concentrations are based on PRZM/EXAMS data.

2 Estimated drinking water concentrations are based on monitoring data
and include parent and degradates.

3 Degradates include cis and trans isomers of both 3-chloroallyl alcohol
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IV.	DEEM-FCID™ Program and Consumption Information

1,3-D chronic dietary exposure assessments were conducted using the
Dietary Exposure Evaluation Model software with the Food Commodity
Intake Database DEEM-FCID™, Version 2.03 which incorporates
consumption data from USDA’s Continuing Surveys of Food Intakes by
Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98 data are based
on the reported consumption of more than 20,000 individuals over two
non-consecutive survey days.  Foods “as consumed” (e.g., apple pie)
are linked to EPA-defined food commodities (e.g. apples, peeled fruit -
cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S,
baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA.  For chronic exposure assessment,
consumption data are averaged for the entire U.S. population and within
population subgroups, but for acute exposure assessment are retained as
individual consumption events.  Based on analysis of the 1994-96, 98
CSFII consumption data, which took into account dietary patterns and
survey respondents, HED concluded that it is most appropriate to report
risk for the following population subgroups: the general U.S.
population, all infants (<1 year old), children 1-2, children 3-5,
children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+
years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

V.	Toxicological Information

The dietary endpoints were selected for the Reregistration Eligibility
Decision Document (D. Vogel, 4/12/07, D337328).  No acute endpoints were
selected as no hazard attributed to a single exposure was identified. 
As this is the first food use for this chemical, the risk assessment
team met and concluded that the FQPA safety factor can be reduced to 1x
as there are no outstanding data, there is no evidence of susceptibility
following in utero and/or postnatal exposure in the developmental
inhalation toxicity studies in rats or rabbits, and in the 2-generation
inhalation rat reproduction study, and there are no residual
uncertainties concerning pre- and post-natal toxicity and no
neurotoxicity concerns.  The endpoints are presented in Table 3.

Table 3. Summary of Toxicological Dose and Endpoints for Use in
1,3-Dichloropropene Dietary Risk Assessments

Exposure/

Scenario	Point of Departure	Uncertainty/

FQPA Safety Factors	Population Adjusted Dose	Study and Toxicological
Effects

1,3-D Combined with Degradates: 3-Chloroallyl Alcohol and 3-
Chloroacrylic Acid  

Acute Dietary Exposure (any Subpopulation)	NA	NA	NA	No hazard was
identified attributable to a single exposure.

Chronic Dietary Exposure	NOAEL = 2.5 mg/kg/day

UF = 100 

	UFA= 10x

UFH=10x

FQPA SF= 1x

	Chronic PAD = 0.025 mg/kg/day	2- Year Combined Chronic/Carcinogenicity
study -Rats 

LOAEL = 12.5 mg/kg/day

Decreased body weight gain, increased incidence of basal cell
hyperplasia of nonglandular stomach mucosa 

Cancer (oral)

	Classified as “likely to be carcinogenic in humans.  

Q1 * =  1.22x 10-1 (mg/kg/day)-1	2- Year Combined
Chronic/Carcinogenicity study -Rats

Combined forestomach, liver, mammary thyroid, adrenal, urinary, lung
tumors, multistage model, 3/4 scaling factor. 

Impurity: 1,2-Dichloropropane

Cancer (Oral)	Classified as “likely to be carcinogenic in humans.  

Q1 * = 3.69x 10-2 (mg/kg/day)-1	2-year Carcinogenicity Study in Mice and
Rats, B2 Carcinogen (“likely to be carcinogenic in humans” (EPA,
1990)

Incidence of hepatocellular adenomas and/or carcinomas in male mouse,
multistage model, 3/4 scaling factor

UF = uncertainty factor. NOAEL = no observed adverse effect level. LOAEL
= lowest observed adverse effect level. RfD = reference dose. UFA =
extrapolation from animal to human (interspecies).  UFH = potential
variation in sensitivity among members of the human population
(intraspecies). NA = Not Applicable 

VI.	Results/Discussion 

As stated above, for chronic assessments, HED is concerned when dietary
risk exceeds 100% of the PAD or RfD.  The DEEM-FCID™ analyses estimate
the dietary exposure of the U.S. population and various population
subgroups.  The results reported in Table 4 are for the general U.S.
Population, all infants (<1 year old), children 1-2, children 3-5,
children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+
years.  Cancer risk is determined for the general U.S. population only.

Results of Chronic Dietary Exposure Analysis

The results of the chronic dietary exposure analysis are reported in the
summary table below.  The dietary exposure is less than 1% of the
population adjusted dose for all population groups for food alone and
food plus tap water from ground water sources, and is less than 5% of
the population adjusted dose for all population groups for food plus
water from surface water sources.  The most highly exposed subgroups are
infants when the water source is surface water, and children aged 1-2
when the water sources are from ground water.

Table 4.  Summary of Chronic Dietary Exposure and Risk for
1,3-Dichloropropene

Population Subgroup	Chronic Dietary

Food Only	Chronic Dietary

Food and Water- Ground Water Sources 2	Chronic Dietary

Food and Water – Surface Water Sources 3

	Dietary Exposure (mg/kg/day)	% cPAD1	Dietary Exposure

(mg/kg/day)	% cPAD1	Dietary Exposure

(mg/kg/day)	% cPAD1

General U.S. Population	0.000003	<1	0.000006	<1	0.000344	1.4

All Infants (< 1 year old)	0.000005	<1	0.000015	<1	0.00112	4.5

Children 1-2 years old	0.000016	<1	0.00002	<1	0.000523	2.1

Children 3-5 years old	0.00001	<1	0.000014	<1	0.000484	1.9

Children 6-12 years old	0.000004	<1	0.000007	<1	0.000331	1.3

Youth 13-19 years old	0.000001	<1	0.000003	<1	0.000248	1.0

Adults 20-49 years old	0.000002	<1	0.000005	<1	0.000321	1.3

Adults 50+ years old	0.000002	<1	0.000005	<1	0.000337	1.3

Females 13-49 years old	0.000002	<1	0.000005	<1	0.000319	1.3

1 The values for the highest exposed population are bolded.

 water value (0.14 μg/L) was used in this assessment for ground water
exposure 

3  The PRZM/EXAMS estimate of 16.2 μg/L was used for the drinking water
estimate from surface water sources.

Results of Cancer Dietary Exposure Analysis

Cancer dietary exposure analyses were conducted for the combined
residues of parent and the CAAL and CAAC degradates for food alone, food
plus drinking water from ground water sources, and food plus drinking
water from surface water sources.  A cancer dietary exposure analysis
was also conducted for the formulation contaminant 1,2-dichloropropane
for drinking water from surface or groundwater sources.  Results of the
dietary exposure analyses are presented in Table 5.

Cancer risks are expressed to one significant figure to allow better
characterization of changes in risk which might result from potential
risk mitigation.  Also, the risk should generally not be assumed to
exceed the benchmark level of concern of 10-6 until the calculated risks
exceed approximately 3 x 10-6.

The estimated risk from 1,3-D exposure for food alone or food and
drinking water from groundwater sources are well below the level of
concern.  The estimated risk for 1,3-D exposure and drinking water from
surface water sources and the estimated risk for 1,2-dichloropropane in
drinking water exceed the level of concern.  The driver for the risk
exceedances is drinking water.  

Table 5.  Summary of Cancer Dietary Exposure and Risk for
1,3-Dichloropropene

Population Subgroup	Cancer Dietary Assessment

Food Only	Cancer Dietary Assessment

Food and Water 1

	Dietary Exposure (mg/kg/day)	Risk	Dietary Exposure

(mg/kg/day)	Risk

General U.S. Population – 1,3-D and degradates – ground water
sources for drinking water	0.000003	3 x 10-7	0.000006	7 x 10-7

General U.S. Population – 1,3-D and degradates– surface water
sources for drinking water	0.000003	3 x 10-7	0.000344	4 x 10-5

General U.S. Population – 1,2-dichloropropane contaminant –

Surface water EDWC	Not Applicable	Not Applicable	0.000188	7 x 10-6

General U.S. Population – 1,2-dichloropropane contaminant –

14 μg/L) was used in this assessment for ground water exposure and 16.2
μg/L for the drinking water from surface water sources.

VII.	Characterization of Inputs/Outputs

Adequate field trial residue data from exaggerated rate studies were
used to estimate residues in food.  The actual food exposure is likely
to be lower than estimated herein as this assessment assumes that all
grapes consumed in the US are treated, and the residue levels are taken
from studies where the application rate is higher than the proposed
label rate.  

The driver for the risk exceedances is drinking water.  HED believes the
actual water concentrations are likely to be lower than the estimates. 
The tap water monitoring results used in the ground water assessments
are considerably lower than prior estimates from ground water models or
targeted ground water monitoring studies.  Accordingly, it is likely
that if comparable monitoring studies were conducted for 1,3-D (from
surface water sources) or 1,2-dichloropropane (all sources), the
estimated concentrations would be much lower.

VIII.	Conclusions

Chronic and cancer dietary exposure analyses were conducted to support a
new use of 1,3-dichloropropene in established grape vineyards.  The
chronic analyses include residues of the parent and four degradates. The
dietary exposure is less than 1% of the population adjusted dose for all
population groups for food alone and food plus tap water from ground
water sources, and is less than 5% of the population adjusted dose for
all population groups for food plus water from surface water sources. 
The residue estimate was slightly refined, but the assessment assumes
all grape products consumed in the US are treated.

Cancer dietary exposure analyses were conducted for the combined
residues of parent and degradates as well as a separate analyses for the
formulation contaminant 1,2-dichloropropane.  The cancer risk for the
combined residues of parent and degradates is below the level of concern
for food exposure and food plus drinking water, when the tap water
monitoring data are used for the estimated drinking water
concentrations.  The cancer risk exceeds the level of concern when the
drinking water concentrations are estimated from models or targeted
monitoring studies in high use areas, or where water is sampled in the
field.  Although these risks exceed the level of concern, tap water
monitoring studies in high use areas show much lower water
concentrations than modeling or targeted monitoring in the field. 
Accordingly if comparable tap water monitoring were available, HED
believes the risks would be below the level of concern.

IX.		List of Attachments

Chronic/Cancer Food Residue Input File for 1,3-Dichloropropene

Chronic/Cancer Food Plus Water (Ground Water Sources) Residue Input File
for 1,3-Dichloropropene

Chronic/Cancer Food Plus Water (Surface Water Sources) Residue Input
File for 1,3-Dichloropropene

Chronic Food Results File for 1,3-Dichloropropene

Chronic Food Plus Water (Ground Water Sources) Results File for
1,3-Dichloropropene

Chronic Food Plus Water (Surface Water Sources) Results File for
1,3-Dichloropropene

Cancer Food Results File for 1,3-Dichloropropene

Cancer Food Plus Water (Ground Water Sources) Results File for
1,3-Dichloropropene

Cancer Food Plus Water (Surface Water Sources) Results File for
1,3-Dichloropropene

Cancer Water (Ground Water Sources) Residue Input File for
1,2-Dichloropropane

Cancer Water (Surface Water Sources) Residue Input File for
1,2-Dichloropropane

Cancer Water (Ground Water Sources) Results File for 1,2-Dichloropropane

Cancer Water (Surface Water Sources) Results File for
1,2-Dichloropropane

cc:	COlinger



Chronic/Cancer Food Residue Input File for 1,3-Dichloropropene

"1,3-dichloropropene"

 0.025 

FCID1, 0 

NOEL,          0  0  0.122 

05-11-2007/11:20:03

-1  "ARs at 0.0055 ppm food only"

 999  0 

 230 "95001750","O", 0.0055  1  1  0 "Grape", ""

 231 "95001760","O", 0.0055  1  1  0 "Grape, juice", ""

 232 "95001761","O", 0.0055  1  1  0 "Grape, juice-babyfood", ""

 233 "95001770","O", 0.0055  1  1  0 "Grape, leaves", ""

 234 "95001780","O", 0.0055  1  1  0 "Grape, raisin", ""

 235 "95001790","O", 0.0055  1  1  0 "Grape, wine and sherry", ""

Chronic/Cancer Food Plus Water (Ground Water Sources) Residue Input
File for 1,3-Dichloropropene

"1,3-dichloropropene"

 0.025 

FCID1, 0 

NOEL,          0  0  0.122 

05-11-2007/11:20:44

-1  "Grapes at 0.0055, used tap water nos. at 0.000145 ppm"

 999  0 

 230 "95001750","O", 0.0055  1  1  0 "Grape", ""

 231 "95001760","O", 0.0055  1  1  0 "Grape, juice", ""

 232 "95001761","O", 0.0055  1  1  0 "Grape, juice-babyfood", ""

 233 "95001770","O", 0.0055  1  1  0 "Grape, leaves", ""

 234 "95001780","O", 0.0055  1  1  0 "Grape, raisin", ""

 235 "95001790","O", 0.0055  1  1  0 "Grape, wine and sherry", ""

 532 "86010000","O", 0.000145  1  1  0 "Water, direct, all sources", ""

 533 "86020000","O", 0.000145  1  1  0 "Water, indirect, all sources",
""

Chronic/Cancer Food Plus Water (Surface Water Sources) Residue Input
File for 1,3-Dichloropropene

"1,3-dichloropropene"

 0.025 

FCID1, 0 

NOEL,          0  0  0.122 

05-22-2007/09:47:35

-1  "Grapes at 0.0055, used surface water nos. at 0.0162 ppm"

 999  0 

 230 "95001750","O", 0.0055  1  1  0 "Grape", ""

 231 "95001760","O", 0.0055  1  1  0 "Grape, juice", ""

 232 "95001761","O", 0.0055  1  1  0 "Grape, juice-babyfood", ""

 233 "95001770","O", 0.0055  1  1  0 "Grape, leaves", ""

 234 "95001780","O", 0.0055  1  1  0 "Grape, raisin", ""

 235 "95001790","O", 0.0055  1  1  0 "Grape, wine and sherry", ""

 532 "86010000","O", 0.0162  1  1  0 "Water, direct, all sources", ""

 533 "86020000","O", 0.0162  1  1  0 "Water, indirect, all sources", ""

Chronic Food Results File for 1,3-Dichloropropene

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for 1,3-DICHLOROPROPENE              (1994-98
data)

Residue file name: C:\Documents and Settings\colinger\My
Documents\Fumigants\NEWTELONEUSE\telonegrapeNewusetolerancefoodonlyREFIN
ED2.R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 05-11-2007/11:21:36     Residue file dated:
05-11-2007/11:20:03/8

Reference dose (RfD, Chronic) = .025 mg/kg bw/day

COMMENT 1: ARs at 0.0055 ppm food only

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.000003                
0.0%

U.S. Population (spring season)             0.000003                
0.0%

U.S. Population (summer season)             0.000003                
0.0%

U.S. Population (autumn season)             0.000003                
0.0%

U.S. Population (winter season)             0.000003                
0.0%

Northeast region                            0.000003                
0.0%

Midwest region                              0.000003                
0.0%

Southern region                             0.000002                
0.0%

Western region                              0.000003                
0.0%

Hispanics                                   0.000002                
0.0%

Non-hispanic whites                         0.000003                
0.0%

Non-hispanic blacks                         0.000002                
0.0%

Non-hisp/non-white/non-black                0.000002                
0.0%

All infants (< 1 year)                      0.000005                
0.0%

Nursing infants                             0.000002                
0.0%

Non-nursing infants                         0.000006                
0.0%

Children 1-6  yrs                           0.000011                
0.0%

Children 7-12 yrs                           0.000003                
0.0%

Females 13-19 (not preg or nursing)         0.000002                
0.0%

Females 20+ (not preg or nursing)           0.000002                
0.0%

Females 13-50 yrs                           0.000002                
0.0%

Females 13+ (preg/not nursing)              0.000001                
0.0%

Females 13+ (nursing)                       0.000002                
0.0%

Males 13-19 yrs                             0.000001                
0.0%

Males 20+ yrs                               0.000002                
0.0%

Seniors 55+                                 0.000002                
0.0%

Children 1-2 yrs                            0.000016                
0.1%

Children 3-5 yrs                            0.000010                
0.0%

Children 6-12 yrs                           0.000004                
0.0%

Youth 13-19 yrs                             0.000001                
0.0%

Adults 20-49 yrs                            0.000002                
0.0%

Adults 50+ yrs                              0.000002                
0.0%

Females 13-49 yrs                           0.000002                
0.0%

------------------------------------------------------------------------
-------

Chronic Food Plus Water (Ground Water Sources) Results File for
1,3-Dichloropropene

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for 1,3-DICHLOROPROPENE              (1994-98
data)

Residue file name: C:\Documents and Settings\colinger\My
Documents\Fumigants\NEWTELONEUSE\telonegrapeNewusetolerancefoodandwaterR
EFINED2.R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 05-15-2007/10:12:43     Residue file dated:
05-11-2007/11:20:44/8

Reference dose (RfD, Chronic) = .025 mg/kg bw/day

COMMENT 1: Grapes at 0.0055, used tap water nos. at 0.000145 ppm

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.000006                
0.0%

U.S. Population (spring season)             0.000006                
0.0%

U.S. Population (summer season)             0.000006                
0.0%

U.S. Population (autumn season)             0.000006                
0.0%

U.S. Population (winter season)             0.000006                
0.0%

Northeast region                            0.000006                
0.0%

Midwest region                              0.000006                
0.0%

Southern region                             0.000005                
0.0%

Western region                              0.000006                
0.0%

Hispanics                                   0.000006                
0.0%

Non-hispanic whites                         0.000006                
0.0%

Non-hispanic blacks                         0.000005                
0.0%

Non-hisp/non-white/non-black                0.000006                
0.0%

All infants (< 1 year)                      0.000015                
0.1%

Nursing infants                             0.000006                
0.0%

Non-nursing infants                         0.000018                
0.1%

Children 1-6  yrs                           0.000015                
0.1%

Children 7-12 yrs                           0.000006                
0.0%

Females 13-19 (not preg or nursing)         0.000004                
0.0%

Females 20+ (not preg or nursing)           0.000005                
0.0%

Females 13-50 yrs                           0.000005                
0.0%

Females 13+ (preg/not nursing)              0.000004                
0.0%

Females 13+ (nursing)                       0.000006                
0.0%

Males 13-19 yrs                             0.000003                
0.0%

Males 20+ yrs                               0.000004                
0.0%

Seniors 55+                                 0.000005                
0.0%

Children 1-2 yrs                            0.000020                
0.1%

Children 3-5 yrs                            0.000014                
0.1%

Children 6-12 yrs                           0.000007                
0.0%

Youth 13-19 yrs                             0.000003                
0.0%

Adults 20-49 yrs                            0.000005                
0.0%

Adults 50+ yrs                              0.000005                
0.0%

Females 13-49 yrs                           0.000005                
0.0%

------------------------------------------------------------------------
-------

Chronic Food Plus Water (Surface Water Sources) Results File for
1,3-Dichloropropene

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for 1,3-DICHLOROPROPENE              (1994-98
data)

Residue file name: C:\Documents and Settings\colinger\My
Documents\Fumigants\NEWTELONEUSE\telonegrapeNewusetolerancefoodandsurfac
ewaterREFINED2.R98                             Adjustment factor #2 NOT
used.

Analysis Date 05-22-2007/09:48:16     Residue file dated:
05-22-2007/09:47:35/8

Reference dose (RfD, Chronic) = .025 mg/kg bw/day

COMMENT 1: Grapes at 0.0055, used surface water nos. at 0.0162 ppm

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.000344                
1.4%

U.S. Population (spring season)             0.000341                
1.4%

U.S. Population (summer season)             0.000370                
1.5%

U.S. Population (autumn season)             0.000333                
1.3%

U.S. Population (winter season)             0.000333                
1.3%

Northeast region                            0.000315                
1.3%

Midwest region                              0.000348                
1.4%

Southern region                             0.000327                
1.3%

Western region                              0.000394                
1.6%

Hispanics                                   0.000390                
1.6%

Non-hispanic whites                         0.000336                
1.3%

Non-hispanic blacks                         0.000327                
1.3%

Non-hisp/non-white/non-black                0.000421                
1.7%

All infants (< 1 year)                      0.001124                
4.5%

Nursing infants                             0.000417                
1.7%

Non-nursing infants                         0.001392                
5.6%

Children 1-6  yrs                           0.000488                
2.0%

Children 7-12 yrs                           0.000314                
1.3%

Females 13-19 (not preg or nursing)         0.000242                
1.0%

Females 20+ (not preg or nursing)           0.000343                
1.4%

Females 13-50 yrs                           0.000332                
1.3%

Females 13+ (preg/not nursing)              0.000333                
1.3%

Females 13+ (nursing)                       0.000475                
1.9%

Males 13-19 yrs                             0.000252                
1.0%

Males 20+ yrs                               0.000308                
1.2%

Seniors 55+                                 0.000337                
1.3%

Children 1-2 yrs                            0.000523                
2.1%

Children 3-5 yrs                            0.000484                
1.9%

Children 6-12 yrs                           0.000331                
1.3%

Youth 13-19 yrs                             0.000248                
1.0%

Adults 20-49 yrs                            0.000321                
1.3%

Adults 50+ yrs                              0.000337                
1.3%

Females 13-49 yrs                           0.000319                
1.3%

------------------------------------------------------------------------
-------

Cancer Food Results File for 1,3-Dichloropropene

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for 1,3-DICHLOROPROPENE              (1994-98
data)

Residue file name: C:\Documents and Settings\colinger\My
Documents\Fumigants\NEWTELONEUSE\telonegrapeNewusetolerancefoodonlyREFIN
ED2.R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 05-11-2007/11:21:13     Residue file dated:
05-11-2007/11:20:03/8

Q* = 0.122 

COMMENT 1: ARs at 0.0055 ppm food only

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg         Lifetime risk

           Subgroup                       body wt/day       (Q*= .122)

--------------------------------------   -------------     -------------

U.S. Population (total)                     0.000003         3.42E-07

U.S. Population (spring season)             0.000003         3.22E-07

U.S. Population (summer season)             0.000003         3.76E-07

U.S. Population (autumn season)             0.000003         3.25E-07

U.S. Population (winter season)             0.000003         3.44E-07

Northeast region                            0.000003         4.13E-07

Midwest region                              0.000003         3.36E-07

Southern region                             0.000002         2.93E-07

Western region                              0.000003         3.61E-07

Hispanics                                   0.000002         2.72E-07

Non-hispanic whites                         0.000003         3.65E-07

Non-hispanic blacks                         0.000002         3.02E-07

Non-hisp/non-white/non-black                0.000002         2.43E-07

All infants (< 1 year)                      0.000005         5.73E-07

Nursing infants                             0.000002         2.22E-07

Non-nursing infants                         0.000006         7.06E-07

Children 1-6  yrs                           0.000011         1.32E-06

Children 7-12 yrs                           0.000003         4.25E-07

Females 13-19 (not preg or nursing)         0.000002         1.83E-07

Females 20+ (not preg or nursing)           0.000002         2.49E-07

Females 13-50 yrs                           0.000002         2.37E-07

Females 13+ (preg/not nursing)              0.000001         1.24E-07

Females 13+ (nursing)                       0.000002         1.84E-07

Males 13-19 yrs                             0.000001         1.15E-07

Males 20+ yrs                               0.000002         1.98E-07

Seniors 55+                                 0.000002         2.51E-07

Children 1-2 yrs                            0.000016         1.92E-06

Children 3-5 yrs                            0.000010         1.17E-06

Children 6-12 yrs                           0.000004         4.48E-07

Youth 13-19 yrs                             0.000001         1.48E-07

Adults 20-49 yrs                            0.000002         2.10E-07

Adults 50+ yrs                              0.000002         2.45E-07

Females 13-49 yrs                           0.000002         2.28E-07

------------------------------------------------------------------------
-------

Cancer Food Plus Water (Ground Water Sources) Results File for
1,3-Dichloropropene

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for 1,3-DICHLOROPROPENE              (1994-98
data)

Residue file name: C:\Documents and Settings\colinger\My
Documents\Fumigants\NEWTELONEUSE\telonegrapeNewusetolerancefoodandwaterR
EFINED2.R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 05-15-2007/10:13:05     Residue file dated:
05-11-2007/11:20:44/8

Q* = 0.122 

COMMENT 1: Grapes at 0.0055, used tap water nos. at 0.000145 ppm

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg         Lifetime risk

           Subgroup                       body wt/day       (Q*= .122)

--------------------------------------   -------------     -------------

U.S. Population (total)                     0.000006         7.14E-07

U.S. Population (spring season)             0.000006         6.91E-07

U.S. Population (summer season)             0.000006         7.77E-07

U.S. Population (autumn season)             0.000006         6.86E-07

U.S. Population (winter season)             0.000006         7.04E-07

Northeast region                            0.000006         7.53E-07

Midwest region                              0.000006         7.13E-07

Southern region                             0.000005         6.47E-07

Western region                              0.000006         7.89E-07

Hispanics                                   0.000006         6.95E-07

Non-hispanic whites                         0.000006         7.29E-07

Non-hispanic blacks                         0.000005         6.56E-07

Non-hisp/non-white/non-black                0.000006         7.00E-07

All infants (< 1 year)                      0.000015         1.80E-06

Nursing infants                             0.000006         6.76E-07

Non-nursing infants                         0.000018         2.22E-06

Children 1-6  yrs                           0.000015         1.84E-06

Children 7-12 yrs                           0.000006         7.63E-07

Females 13-19 (not preg or nursing)         0.000004         4.45E-07

Females 20+ (not preg or nursing)           0.000005         6.21E-07

Females 13-50 yrs                           0.000005         5.98E-07

Females 13+ (preg/not nursing)              0.000004         4.87E-07

Females 13+ (nursing)                       0.000006         7.01E-07

Males 13-19 yrs                             0.000003         3.89E-07

Males 20+ yrs                               0.000004         5.32E-07

Seniors 55+                                 0.000005         6.17E-07

Children 1-2 yrs                            0.000020         2.47E-06

Children 3-5 yrs                            0.000014         1.69E-06

Children 6-12 yrs                           0.000007         8.06E-07

Youth 13-19 yrs                             0.000003         4.18E-07

Adults 20-49 yrs                            0.000005         5.59E-07

Adults 50+ yrs                              0.000005         6.11E-07

Females 13-49 yrs                           0.000005         5.74E-07

------------------------------------------------------------------------
-------

Cancer Food Plus Water (Surface Water Sources) Results File for
1,3-Dichloropropene

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for 1,3-DICHLOROPROPENE              (1994-98
data)

Residue file name: C:\Documents and Settings\colinger\My
Documents\Fumigants\NEWTELONEUSE\telonegrapeNewusetolerancefoodandsurfac
ewaterREFINED2.R98                                            
Adjustment factor #2 NOT used.

Analysis Date 05-22-2007/09:48:46     Residue file dated:
05-22-2007/09:47:35/8

Q* = 0.122 

COMMENT 1: Grapes at 0.0055, used surface water nos. at 0.0162 ppm

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg         Lifetime risk

           Subgroup                       body wt/day       (Q*= .122)

--------------------------------------   -------------     -------------

U.S. Population (total)                     0.000344         4.20E-05

U.S. Population (spring season)             0.000341         4.16E-05

U.S. Population (summer season)             0.000370         4.51E-05

U.S. Population (autumn season)             0.000333         4.06E-05

U.S. Population (winter season)             0.000333         4.06E-05

Northeast region                            0.000315         3.84E-05

Midwest region                              0.000348         4.25E-05

Southern region                             0.000327         3.99E-05

Western region                              0.000394         4.81E-05

Hispanics                                   0.000390         4.76E-05

Non-hispanic whites                         0.000336         4.10E-05

Non-hispanic blacks                         0.000327         3.98E-05

Non-hisp/non-white/non-black                0.000421         5.13E-05

All infants (< 1 year)                      0.001124         1.37E-04

Nursing infants                             0.000417         5.09E-05

Non-nursing infants                         0.001392         1.70E-04

Children 1-6  yrs                           0.000488         5.95E-05

Children 7-12 yrs                           0.000314         3.83E-05

Females 13-19 (not preg or nursing)         0.000242         2.95E-05

Females 20+ (not preg or nursing)           0.000343         4.18E-05

Females 13-50 yrs                           0.000332         4.05E-05

Females 13+ (preg/not nursing)              0.000333         4.06E-05

Females 13+ (nursing)                       0.000475         5.79E-05

Males 13-19 yrs                             0.000252         3.08E-05

Males 20+ yrs                               0.000308         3.75E-05

Seniors 55+                                 0.000337         4.11E-05

Children 1-2 yrs                            0.000523         6.38E-05

Children 3-5 yrs                            0.000484         5.91E-05

Children 6-12 yrs                           0.000331         4.04E-05

Youth 13-19 yrs                             0.000248         3.03E-05

Adults 20-49 yrs                            0.000321         3.91E-05

Adults 50+ yrs                              0.000337         4.12E-05

Females 13-49 yrs                           0.000319         3.90E-05

------------------------------------------------------------------------
-------

Cancer Water (Ground Water Sources) Residue Input File for
1,2-Dichloropropane

"1,2-dichloropropane"

 0 

FCID1, 0 

NOEL,          0  0  0.0369 

05-17-2007/13:39:04

-1  "Telone contaminant;  water only assessment- groundwater at 3.97
ppb"

 999  0 

 532 "86010000","O", 0.00397  1  1  0 "Water, direct, all sources", ""

 533 "86020000","O", 0.00397  1  1  0 "Water, indirect, all sources", ""

Cancer Water (Surface Water Sources) Residue Input File for
1,2-Dichloropropane

"1,2-dichloropropane"

 0 

FCID1, 0 

NOEL,          0  0  0.0369 

05-17-2007/13:26:40

-1  "Telone contaminant;  water only assessment"

 999  0 

 532 "86010000","O", 0.0089  1  1  0 "Water, direct, all sources", ""

 533 "86020000","O", 0.0089  1  1  0 "Water, indirect, all sources", ""

Cancer Water (Ground Water Sources) Results File for
1,2-Dichloropropane

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for 1,2-DICHLOROPROPANE              (1994-98
data)

Residue file name: C:\Documents and Settings\colinger\My
Documents\Fumigants\NEWTELONEUSE\12dichloropropenenewusegroundwater.R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 05-17-2007/13:39:40     Residue file dated:
05-17-2007/13:39:04/8

Q* = 0.0369 

COMMENT 1: Telone contaminant;  water only assessment- groundwater at
3.97 ppb

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg         Lifetime risk

           Subgroup                       body wt/day       (Q*= .0369)

--------------------------------------   -------------     -------------

U.S. Population (total)                     0.000084         3.09E-06

U.S. Population (spring season)             0.000083         3.06E-06

U.S. Population (summer season)             0.000090         3.32E-06

U.S. Population (autumn season)             0.000081         2.98E-06

U.S. Population (winter season)             0.000081         2.99E-06

Northeast region                            0.000076         2.82E-06

Midwest region                              0.000085         3.12E-06

Southern region                             0.000080         2.93E-06

Western region                              0.000096         3.54E-06

Hispanics                                   0.000095         3.50E-06

Non-hispanic whites                         0.000082         3.01E-06

Non-hispanic blacks                         0.000079         2.93E-06

Non-hisp/non-white/non-black                0.000103         3.79E-06

All infants (< 1 year)                      0.000274         1.01E-05

Nursing infants                             0.000102         3.75E-06

Non-nursing infants                         0.000340         1.25E-05

Children 1-6  yrs                           0.000117         4.31E-06

Children 7-12 yrs                           0.000076         2.80E-06

Females 13-19 (not preg or nursing)         0.000059         2.17E-06

Females 20+ (not preg or nursing)           0.000084         3.08E-06

Females 13-50 yrs                           0.000081         2.99E-06

Females 13+ (preg/not nursing)              0.000081         3.00E-06

Females 13+ (nursing)                       0.000116         4.28E-06

Males 13-19 yrs                             0.000062         2.27E-06

Males 20+ yrs                               0.000075         2.77E-06

Seniors 55+                                 0.000082         3.03E-06

Children 1-2 yrs                            0.000124         4.59E-06

Children 3-5 yrs                            0.000116         4.29E-06

Children 6-12 yrs                           0.000080         2.96E-06

Youth 13-19 yrs                             0.000060         2.23E-06

Adults 20-49 yrs                            0.000078         2.88E-06

Adults 50+ yrs                              0.000082         3.03E-06

Females 13-49 yrs                           0.000078         2.87E-06

------------------------------------------------------------------------
-------

Cancer Water (Surface Water Sources) Results File for
1,2-Dichloropropane

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for 1,2-DICHLOROPROPANE              (1994-98
data)

Residue file name: C:\Documents and Settings\colinger\My
Documents\Fumigants\NEWTELONEUSE\12dichloropropenenewusewater.R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 05-17-2007/13:37:44     Residue file dated:
05-17-2007/13:26:40/8

Q* = 0.0369 

COMMENT 1: Telone contaminant;  water only assessment

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg         Lifetime risk

           Subgroup                       body wt/day       (Q*= .0369)

--------------------------------------   -------------     -------------

U.S. Population (total)                     0.000188         6.92E-06

U.S. Population (spring season)             0.000186         6.86E-06

U.S. Population (summer season)             0.000202         7.44E-06

U.S. Population (autumn season)             0.000181         6.69E-06

U.S. Population (winter season)             0.000181         6.69E-06

Northeast region                            0.000171         6.31E-06

Midwest region                              0.000190         7.00E-06

Southern region                             0.000178         6.58E-06

Western region                              0.000215         7.93E-06

Hispanics                                   0.000213         7.86E-06

Non-hispanic whites                         0.000183         6.75E-06

Non-hispanic blacks                         0.000178         6.57E-06

Non-hisp/non-white/non-black                0.000230         8.49E-06

All infants (< 1 year)                      0.000615         2.27E-05

Nursing infants                             0.000228         8.42E-06

Non-nursing infants                         0.000762         2.81E-05

Children 1-6  yrs                           0.000262         9.67E-06

Children 7-12 yrs                           0.000170         6.29E-06

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nursing)         0.000132         4.87E-06

Females 20+ (not preg or nursing)           0.000187         6.91E-06

Females 13-50 yrs                           0.000181         6.70E-06

Females 13+ (preg/not nursing)              0.000182         6.73E-06

Females 13+ (nursing)                       0.000260         9.59E-06

Males 13-19 yrs                             0.000138         5.09E-06

Males 20+ yrs                               0.000168         6.20E-06

Seniors 55+                                 0.000184         6.80E-06

Children 1-2 yrs                            0.000279         1.03E-05

Children 3-5 yrs                            0.000261         9.62E-06

Children 6-12 yrs                           0.000180         6.64E-06

Youth 13-19 yrs                             0.000136         5.00E-06

Adults 20-49 yrs                            0.000175         6.46E-06

Adults 50+ yrs                              0.000184         6.80E-06

Females 13-49 yrs                           0.000174         6.44E-06

------------------------------------------------------------------------
-------

1,3-Dichloropropene	                    Dietary Exposure and Risk
Assessment                   DP Number:  340060

PC Code:  029001

________________________________________________________________________
_____________	

 PAGE   

Page   PAGE  2  of   NUMPAGES  22 

DRAFT – Confidential, Internal, and Deliberative Material

[Chemical Name]	Dietary Exposure and Risk Assessment	DP Number:
[xxxxxxx]

PC Code:  [xxxxxx]