Document ID: EPA-HQ-OPP-2009-0125-0009
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2010-08-27T04:00Z

BIOPESTICIDES REGISTRATION ACTION DOCUMENT

Calcium Acetate

											PC Code: 011470

	U.S. Environmental Protection Agency

	Office of Pesticide Programs

Biopesticides and Pollution Prevention Division



TABLE OF CONTENTS

 TOC \f I.  EXECUTIVE 
SUMMARY.….....………………………………………………
……...........p.4 

II.  ACTIVE INGREDIENT
OVERVIEW…………...…………………………………………p
.5

III.  REGULATORY
BACKGROUND……………..………………………………………
…..p.5

IV.  RISK
ASSESSMENT……………………………………………………
…………………p.6

A. ACTIVE INGREDIENT
CHARACTERIZATION…………………………………p.6

B.  HUMAN HEALTH
ASSESSMENT………………………………………………..p.7

	1.  Toxicological Hazard
Assessment……………………………………………….p.7

2.  Dose
Response…..…………………………………………………
…………….p.8  

3.  Dietary Exposure and Risk
Characterization…..……………………………..….p.8

	4.  Drinking Water Exposure and Risk
Characterization…..………………….…….p.8

	 5.  Acute and Chronic Dietary Exposure and Risks for Sensitive 

                       Subpopulations, Particularly Infants and
Children..…………...…………..….…p.8

                   6.  Occupational, Residential, School, and Daycare
Exposure and Risk                                               
Characterization……………………………………………...
……...………..…p.9 

	       7.  Aggregate Exposure from Multiple Routes Including Dermal,
Oral, 

and
Inhalation………………………………..……………………
……………..p.9

	       8.  Cumulative
Effects……………………………………………………...
….........p.9

                9.  Risk
Characterization…...……………………………...…………
……………...p.9

	C.  ENVIRONMENTAL
ASSESSMENT..……………………………………………..p.9

	      1.  Summary of Non-Target Organism Testing and Waiver
Rationales…..…….…..p.9

                  2.  Environmental Fate and
Groundwater……………………………………….....p.10

                 	3.  Ecological Exposure and Risk
Characterization………………………….…….p.10 

                  4.  Threatened and Endangered Species
Assessment………………………....……p.10

V.  RISK MANAGEMENT AND REGISTRATION
DECISIONS…………………………..p.11

A. DETERMINATION OF
ELIGIBILITY…………………………………….………p.11

B. REGULATORY
DECISION……………………………………………………….
p.11

C.
LABELING………………………………………………………
…………………p.11

D. ENVIRONMENTAL
JUSTICE……………………………………………………p.12

VI.  ACTIONS REQUIRED BY THE
REGISTRANT……………………………...………...p.12

A. REPORTING OF ADVERSE EFFECTS AND HYPERSENSITIVITY                    
   
INCIDENTS………………………………………………………
………….…….p.12

VII.  APPENDIX A -BIOCHEMICAL PESTICIDE DATA
REQUIREMENTS…...…...……p.13

VIII.  GLOSSARY OF ACRONYMS AND
ABBREVIATIONS…………………………..…p.14

IX.  APPENDIX B - PRODUCT SPECIFIC
INFORMATION…...……..…...………….……p.15

X.  APPENDIX C -
REFERENCES…...…………………….…………………………
…...…p.15

	

  



BIOPESTICIDES REGISTRATION ACTION DOCUMENT TEAM

Office of Pesticide Programs:

Biopesticides and Pollution Prevention Division

Biochemical Pesticides Branch (BPB)

Chief 

Linda A. Hollis, M.S.

Senior Biologist

Russell Jones, Ph.D      

Regulatory Action Leader

Menyon Adams

Product Analyst

Jacob Moore

Product Performance

Clara Fuentes, Ph.D.

I.	     EXECUTIVE SUMMARY:

 The biochemical active ingredient Calcium Acetate is the calcium salt
of acetic acid. It is an odorless white powder. It is intended for
non-food outdoor use to attract eight species of yellow jackets in
traps. 

EPA granted waivers for all Tier I human health toxicity data
requirements due to the fact that no significant human exposure by any
route is anticipated from use of the trap containing this active
ingredient.  EPA also waived most ecological effects data requirements.
All data waiver rationales are predicted on little exposure potential. 
An adequate efficacy study was submitted that also supported the finding
that nontarget organisms are not attracted to traps baited with the
attractant, when used according to label directions..  

The Agency considered human exposure to calcium acetate in light of the
relevant safety factors in FQPA and FIFRA.  A determination has been
made that there are no unreasonable adverse effects to the U.S.
population in general, and to infants and children.  No significant
exposure via drinking water is expected from the use of the yellow
jacket attractant.

Based on the information discussed above, the Agency has determined that
the registered use of calcium acetate as an active ingredient will have
No Adverse Effects (NAE) on threatened and/or endangered species. 
Exposure to endangered or threatened species is not expected since this
is an attractant for yellow jackets and does not attract other nontarget
insect species.  

On October 1, 2009, EPA announced a new policy to provide a more
meaningful opportunity for the public to participate on major
registration decisions before they occur.  According to this new policy,
EPA intends to provide a public comment period prior to making a
registration decision for, at minimum, the following types of
applications: new active ingredients, first food use, first outdoor use,
and first residential use.  

Consistent with the new policy of making registration actions more
transparent, Calcium Acetate has undergone a 30 day comment period as a
“new active ingredient” whose registration would result in a
“first outdoor use” and a “first residential use.”  During this
process, no comments were received. Accordingly, the preliminary
decision to register Calcium Acetate stands.  The basis for the
preliminary decision can be found in the risk assessment for Calcium
Acetate, which is characterized in this BRAD.  As discussed above, acute
toxicity data for demonstrate that it is toxicity category IV.  Calcium
Acetate does not demonstrate subchronic or developmental toxicity, and
it is not mutagenic or genotoxic.  EPA has no concerns for any
non-target organisms exposed to Calcium Acetate in accordance with
approved label directions.  EPA has not identified any toxic endpoints
for non-target mammals, birds, plants, aquatic, or soil organisms. Nor
or there concerns for any threatened and endangered species.  Thus,
given that Calcium Acetate has very low toxicity and presents little if
any risk to non-target organisms, and efficacy data confirm its
effectiveness against target pests, EPA concludes that it is in the best
interests of the public and the environment to issue the registration
for Calcium Acetate.  

The Environmental Protection Agency (EPA) considered information
submitted for granting registration under Section 3(c)(5) of the Federal
Insecticide, Fungicide and Rodenticide Act (FIFRA) and determined that
the information submitted in support of Calcium Acetate yellow jacket
attractant adequately satisfy current data requirements (refer to 40 CFR
Subpart U § 158.2000). 

II.		ACTIVE INGREDIENT OVERVIEW

Common Names: 		 Calcium Acetate

					 Calcium Ethanoate

					 Acetate of lime

Chemical Names: 	 Calcium Acetate

Trade & Other Names: 	 Calcium Acetate

CAS Registry Number:    62-54-4

OPP Chemical Code:       011470 

Type of Pesticide: 		 Attractant

Application rates and methods vary depend ing on the product.  For
specific information regarding the product(s) refer to Appendix B.  

     REGULATORY BACKGROUND

On June 16, 2007, the Agency received an application filed by Bull Run
Scientific, VBT, 7400 Beaufont Springs Drive, Suite 300, Richmond,
Virginia  23225-5519.  Bull Run retained Cynthia Smith of Conn & Smith
as their agent.  Bull Run wishes to register the product Disposable Bull
Run Yellow jacket Trap E containing the new biochemical active
ingredient Calcium Acetate at 19.8%.   A notice of receipt of this
application was published in the Federal Register March 16, 2009 (74 FR
49).  No comments were received following the publication of this
notice.  In addition, on December 15, 2009, EPA provided the opportunity
for a 30-day comment period on the Agency’s draft risk assessment and
intention to register this pesticide product.  EPA has not received any
comment on this proposed action.

A.	Classification

The Biochemical Classification Committee determined that Calcium Acetate
is a biochemical pesticide due to its apparent non-toxic mode of action
and natural occurrence in the environment.

 

B.	Food Clearances/Tolerances 

Currently, this active ingredient is not registered for use on food or
feed commodities because applications are for non-food outdoor use. 
Therefore a tolerance or exemption from the requirement of a tolerance
is not required.

IV.			RISK ASSESSMENT

A.	Active Ingredient Characterization

The new active ingredient calcium acetate will be formulated as an EP
for use as an attractant for yellow jackets. The technical grade active
ingredient (TGAI) is a white odorless powder. 

Calcium acetate occurs naturally as the calcium salt of acetic acid, and
has a non-toxic mode of action.

The descriptions of the product formulation and production process as
well as the formation of impurities were examined by BPPD and found to
be acceptable in meeting current guideline standards.  

All product chemistry data requirements for registration of the new
active ingredient Calcium Acetate have been satisfied. 

	

Guideline Reference No./Property	Description of Result

830.6302	Color	White

830.6303	Physical State	Powder

830.6304	Odor	Odorless

830.6313	Stability	Stable

Not addressed for metals and metal ions

830.6314	Oxidation/Reduction: 

Chemical Incompatibility	Not required for TGAI

830.6315	Flammability	Autoignition temperature = 680-730°C

830.6316	Explodability	Not required for TGAI

830.6317	Storage Stability	Not required for TGAI

830.6319	Miscibility	Not required for TGAI

830.6320	Corrosion Characteristics	Not required for TGAI

830.6321	Dielectric Breakdown Voltage	Not required for TGAI

830.7000	pH	7.2 ± 0.1 at 21°Cb

830.7100	Viscosity	Not applicable, the ingredient is a solid

830.7200	Melting Range	Decomposes to acetone at 160°C

830.7220	Boiling Range	Not applicable, the ingredient is a solid

830.7300	Density/Relative Density/Bulk Density	Approximately 30 lb/ft3

830.7370	Dissociation Constant in Water	pKa = 4.76 at 25°C

830.7550	Partition Coefficient	Log Kow = -1.3774

830.7840	Water Solubility	400 g/L

830.7950	Vapor Pressure	0.00548 mm Hg

B.	Human Health Assessment

Toxicology 

No significant human exposure by any route is anticipated from use of
this active ingredient because it is confined to a water soluble pouch
inside the trap via the securely attached entrance structure. 
Therefore, based upon the relevant data and information, we conclude
that the active ingredient is not likely to result in adverse human
health effects.  With regard to the Human Health Toxicity profile for
Calcium Acetate, all toxicity data requirements have been waived by EPA.
 

	a.	Acute Toxicity

Data waiver rationales were granted by BPPD for all Tier I data
requirements.  This includes the Acute Oral Toxicity, Acute Dermal
Toxicity, Acute Inhalation Toxicity, Acute Eye Irritation, Acute Dermal
Irritation, Dermal Sensitization, Prenatal Developmental Toxicity,
Bacterial Reverse Mutation Test, and the In Vitro Mammalian Cell Gene
Mutagenicity.  No additional toxicity data are required to support the
nonfood use registration of this active ingredient. 

	

	b.	Subchronic Toxicity 

No subchronic toxicity data were submitted with this application for
registration of this new active ingredient . No repeated human oral
exposure is anticipated. 

      c.   Developmental Toxicity and Mutagenicity 

No developmental toxicity data were submitted with this application for
registration because of little to no exposure, low toxicity, and the use
pattern as a non-food use. In addition, Calcium Acetate is a
naturally-occurring substance that is also approved for food-use by FDA
under 40 CFR 184.1185. Also, The Agency considered human exposure to
calcium acetate in light of the relevant safety factors in FIFRA.  It is
not expected that use of the product would result in significant human
exposure when the product is used as directed.  No unreasonable adverse
effects are expected from exposure to this active ingredient when the
product is used according to label instructions.

Chronic exposure and oncogenicity assessment

No chronic exposure and oncogenicity data were submitted with this
application for registration because these data are not required.  

	e.	Effects on the Endocrine System tc \l4 "e.	Effects on the Endocrine
System 

EPA is in the process of issuing test orders for endocrine effects.  The
schedule for issuance of test orders, and details regarding status is
available at http://www.epa.gov/endo/.  EPA has also established a
docket for the test orders in www.regulations.gov under docket number
EPA-HQ-OPP-2009-0634.

Data required under the test orders will provide information to help EPA
identify whether chemicals have the potential to interact with the
estrogen, androgen, and/or thyroid hormone systems, which regulate
growth, metabolism, development, and reproduction.  The data generated
from the screens will provide robust and systematic scientific
information that will help EPA identify whether additional testing is
necessary.

Calcium Acetate is a naturally occurring substance.  To date, there is
no evidence to suggest that our natural exposure to Calcium Acetate
affects the immune system, functions in a manner similar to any known
hormone, or that it acts as an endocrine disruptor.  Moreover, the use
of Calcium Acetate is not expected to result in any significant
exposures, effectively obviating any opportunity for negative effects on
humans or the environment.  Therefore, it is unlikely that Calcium
Acetate will have estrogenic or endocrine effects.

2.	Dose Response Assessment

A dose response assessment was not conducted because based on the
proposed use of the product, human exposure is not expected.  

3.	Dietary Exposure and Risk Characterization

The active ingredient Calcium Acetate is intended for non-food uses. 
Accordingly, it is not expected to pose any direct dietary risk to
humans.  

With regard to any incidental exposure, all routes of exposure
associated with the active ingredient’s use as an attractant are
negligible.  Additionally, the active ingredient occurs naturally in
fruit and is a well-recognized flavor agent in food additives.  Its
regular consumption in a human diet is not associated with any hazards. 
Finally, the acute toxicity information on file indicates that the risks
associated with even incidental exposures would be negligible. 

4.	Drinking Water Exposure Risk Characterization

No significant drinking water exposure is expected from Calcium Acetate
because of its contained in a water soluble pouch inside the trap.

5.	Acute and Chronic Dietary Exposure and Risks for Sensitive
Subpopulations, Particularly Infants and Children 

Based on the non-food use pattern, the limited potential for even
incidental exposure, and the dietary toxicity information discussed
above, EPA concludes that there is a reasonable certainty that no harm
will result to the United States population, including infants and
children, from aggregate exposure to any incidental residues of Calcium
Acetate.    

6.	Occupational, Residential, School and Day Care Exposure and Risk
Characterization

Occupational Exposure and Risk Characterization

There is little likelihood of occupational exposure via oral, dermal, or
ocular routes due to the fact that the end product is in a trap.
Inhalation exposure is minimal and not likely to occur at levels that
would be toxic due to the low concentration of Calcium Acetate in the
end-use product (19.8%).

	b.	Residential, School and Day Care Exposure and Risk Characterization

No indoor residential uses are currently approved. No exposure is
anticipated to children at school or day care facilities because the
pesticide is enclosed in a water soluble pouch inside a trap. 

7.   Aggregate Exposure from Multiple Routes Including Dermal, Oral, and
Inhalation 

The potential for aggregate exposure is expected to be insignificant. 
Calcium Acetate is not expected to be present in quantities greater than
2.466 x 109 g/liter air/week, and limited only to those times when
yellow jackets, hornets and wasps are active.  Given a lack of acute
toxicological endpoints for Calcium Acetate, the aggregate exposure
scenario presents no significant concerns for risk.

8.	Cumulative Effects 

Calcium Acetate is intended for non-food uses as an attractant in a
trap.  No dietary exposures are expected.  To the degree that there
might be any incidental dietary exposure, Calcium Acetate does not share
any known common mechanism of toxicity with other substances.  

9.    Risk Characterization

The Agency considered human exposure to Calcium Acetate in light of the
relevant safety factors in FQPA and FIFRA.  A determination has been
made that no unreasonable adverse effects to the U.S. population in
general, and to infants and children in particular, will result from the
use of the calcium acetate insecticide 

C.	ENVIRONMENTAL ASSESSMENT

Ecological Hazards (Relative to the Biochemical Pesticides Nontarget
Organisms and Environmental Fate Data Requirements- 40 CFR§158.2060)

Calcium Acetate is contained in a water soluble pouch in a trap. The
user must cut open the trap entrance structure, add the appropriate
amount of water to activate the attractant, and hang the trap. The trap
is for a single use and is not designed to be reused or refilled. The
used trap is disposed via trash collection.  Efficacy data were
submitted that demonstrated that nontarget organisms are not attracted
to the Calcium Acetate trap. (MRID 47255003) 

Environmental Fate and Ground Water Data

The need for environmental fate and groundwater data was not triggered
because results of the acute toxicity assessment did not trigger any
additional Tier I studies.

Ecological Exposure and Risk Characterization

The active ingredient is intended for formulation of end use products
that are placed in insect traps for residential or agricultural use.
When used according to the proposed label directions, no direct
exposures are expected for nontarget organisms. Moreover, the active
ingredient is used at a low concentration as an attractant, and is not
expected to accumulate in the environment. Given these characteristics
of Calcium Acetate, nontarget exposure and ecological effects studies
were waived.

		

	4. Threatened and Endangered Species Assessment

Based on the available data, a No Effects (NE) determination was made
Calcium Acetate on threatened and endangered species when the product is
used according to label use directions.  Specifically, in MRID 47451404,
efficacy testing showed no honeybees or other non-target insect species
were attracted or caught by the Calcium Acetate product.  Since the
active ingredient in contained in a trap, there is no exposure to birds,
fish, aquatic invertebrates, or other non-target organisms.

D.	PRODUCT PERFORMANCE DATA (EFFICACY)

Submission of product performance data (OPPTS 810.3000) is listed as a
requirement for all pesticide products. Customarily, the Agency requires
efficacy data to be submitted for review only in connection with the
registration of products directly pertaining to the mitigation of
disease bearing human health organisms and certain designated quarantine
pests, i.e., ticks, mosquitoes, fleas, Mediterranean fruit flies, gypsy
moths, Japanese beetles, etc.  For a list of organisms considered by the
Agency as “public health pests”, please refer to Pesticide
Registration Notice 2002-1 (  HYPERLINK
"http://www.epa.gov/PR_Notices/pr2002-1.pdf" 
http://www.epa.gov/PR_Notices/pr2002-1.pdf ).  

A report on the efficacy of the product was submitted because the yellow
jacket wasp is a public health pest. The study consisted of 7 field
trials conducted on different dates and at different locations
representing different habitats. Traps were emptied and rebaited
periodically. Traps were rotated independently of replenishment, to
avoid possible positional effects. Insects were collected for
identification. Data was analyzed on mean number of insects per trap per
day. Treatment means were compared to control means using a Paired
t-Test with P set 0.05 significance level. Replicates with no recorded
catch were omitted from the analyses. Data was summarized by average
species caught per trap per treatment, and by average species per trap
across all the treatment pooled together. The study results showed
statistically significant difference between treatment and control traps
in number of catches for all wasps. 

V.	    Risk Management Decision

A.	Determination of Eligibility for Registration 

Section 3(c)(5) of FIFRA provides for the registration of a new active
ingredient if it is determined that (A) its composition is such as to
warrant the proposed claims for it; (B) its labeling and other materials
required to be submitted comply with the requirements of FIFRA; (C) it
will perform its intended function without unreasonable adverse effects
on the environment; and (D) when used in accordance with widespread and
commonly recognized practice it will not generally cause unreasonable
adverse effects on the environment. 

The four criteria of the Eligibility Determination for Pesticidal Active
Ingredients are satisfied by the science assessments supporting the
product containing Calcium Acetate.  This product is not expected to
cause unreasonable adverse effects and is likely to act as a yellow
jacket attractant when used according to label instructions. Therefore,
EPA concludes that Calcium Acetate is eligible for registration for the
labeled uses.  

B.	Regulatory Decision

On October 1, 2009, EPA announced a new policy to provide a more
meaningful opportunity for the public to comment on major registration
decisions before they occur.  According to this new policy, EPA intends
to provide a public comment period prior to making a registration
decision for, at minimum, the following types of applications:  new
active ingredients; first food use; first outdoor use; and first
residential use.  Accordingly, this pesticide was subject to a 30-day
comment period as a new active ingredient with both outdoor uses and
residential uses.  No comments were received during that comment period.

At this time, EPA believes, the data submitted fulfill the requirements
of registration for products containing Calcium Acetate for use to
attract yellow jackets, wasps and hornets. Acute toxicity data for
Calcium Acetate demonstrate that it is toxicity category IV for all
routes of exposure. Calcium Acetate does not demonstrate subchronic or
developmental toxicity, and it is not mutagenic or genotoxic.  EPA has
no concerns for any non-target organisms exposed to Calcium Acetate in
accordance with approved label directions.  EPA has not identified any
toxic endpoints for non-target mammals, birds, plants, aquatic, or soil
organisms. Nor are there concerns for any threatened and endangered
species.  Given the non-toxic character of Calcium Acetate, EPA supports
its registration under Section 3(c) (5) of the Federal Insecticide,
Fungicide, and Rodenticide Act (FIFRA).  Refer to Appendix B for
product-specific information.

       1.	Conditional/Unconditional Registration

All data requirements are fulfilled and EPA has determined that an
unconditional registration for Calcium Acetate is warranted under
Section 3(C) (5) of FIFRA.

C.  Labeling

 Before releasing pesticide products containing Calcium Acetate for
shipment, the applicant is required to provide appropriate labels.

D.  Environmental Justice

EPA seeks to achieve environmental justice, the fair treatment and
meaningful involvement of all people, regardless of race, color,
national origin, or income, in the development, implementation, and
enforcement of environmental laws, regulations, and policies. To help
address potential environmental justice issues, the Agency seeks
information on any groups or segments of the population who, as a result
of their location, cultural practices, or other factors, may have
atypical, unusually high exposure to calcium acetate compared to the
general population.  Please comment if you are aware of any
sub-populations that may have atypical, unusually high exposure compared
to the general population.

VI. 	ACTIONS REQUIRED BY REGISTRANTS

The Agency evaluated all of the data submitted in connection with the
initial registration of Calcium Acetate and determined that these data
are sufficient to satisfy current registration data requirements.  No
additional data are required to be submitted to the Agency at this time.
 

Notwithstanding the information stated in the previous paragraph, it
should be clearly understood that certain specific data are required to
be reported to the Agency as a requirement for maintaining the Federal
registration for a pesticide product. A brief summary of these types of
data are listed below.   

A.  Reporting of Adverse Effects

Reports of all incidents of adverse effects to the environment must be
submitted to the Agency under the provisions stated in FIFRA, Section
6(a)(2).

B.	Reporting of Hypersensitivity Incidents

Additionally, all incidents of hypersensitivity (including both
suspected and confirmed incidents) must be reported to the Agency under
the provisions of 40 CFR Part 158.2050(d).

VII.	 Appendix A. Data Requirements (40 CFR Part 158-Subpart U)

*NOTE:  MRID numbers listed in the following tables are representative
of supporting data for the original registration of the product
containing this active ingredient.  Subsequent to this registration,
there may be additional MRIDs that support registration of other
products containing this active ingredient.   

Table 2. Human Toxicology Data Requirements for  Calcium Acetate (40 CFR
§ 158.2050)

Study Type, Species, OPPTS Guideline	Regulatory Decision
LD50/LC50/LOAEL/NOAEL Results	Toxicity Category	MRID

Review Date

Acute Oral Toxicity,  rat, OPPTS 870.1100	Acceptable

Waiver	N/A	WAIVED	47451405

Acute Dermal Toxicity,  rat, 

OPPTS 870.1200	Acceptable

Waiver	N/A	WAIVED	47451405

Acute Inhalation Toxicity,  rat, 

OPPTS 870.1300	Acceptable Waiver	N/A	WAIVED	47451405

Acute Eye Irritation, rabbit, 

OPPTS 870.2400	Acceptable

Waiver	N/A	WAIVED	47451405

Acute Dermal Irritation, rabbit, 

OPPTS 870.2500	Acceptable

Waiver	N/A	WAIVED	47451405

Dermal Sensitization

OPPTS 870.2600	Acceptable

Waiver	N/A	WAIVED	47451405

Prenatal Development

OPPTS 870.3700	Acceptable

Waiver	N/A	WAIVED	47451405

Reproductive Toxicity 

OPPTS

870.3800	Acceptable

Waiver	N/A	WAIVED	47451405

Table 2. Human Toxicology Data Requirements for  Calcium Acetate (40 CFR
§ 158.2050)

Study Type, Species, OPPTS Guideline	Regulatory Decision
LD50/LC50/LOAEL/NOAEL Results	Toxicity Category	MRID

Review Date

Bacterial Reverse Mutation Test

OPPTS 

870.5100	Acceptable

Waiver	N/A	WAIVED	47451405

In vitro Mammalian Cell Gene Mutation Assay

OPPTS

870.5300	Acceptable

Waiver	N/A	WAIVED	47451405

Acute Neurotoxicity

OPPTS

870.6200	Acceptable

Waiver	N/A	WAIVED	47451405

Table 3. Nontarget Organism, Fate and Expression Data Requirements for
Calcium Acetate (40 CFR § 158.2060)

Study/OPPTS Guideline No.	Results	MRID #(s)

Avian acute oral toxicity 

(850.2100)	Waived	47451404

Vegetative Vigor	

(850.4150)	Waived	47451404

Nontarget insect toxicity (Honey bee)

(850.3020)	Waived	47451404

Aquatic Invertebrate Acute Toxicity	

(850.1010)	Waived	47451404

Seeding Emergence

 (850.4100)	Waived	47451404

Oyster Acute Toxicity 

(850.1025)	Waived	47451404

Fish Acute Toxicity, Freshwater

(850.1075)	Waived	47451404

Daphnid Chronic Toxicity

(850.1300)	Waived	47451404

Fish Early-Life Stage Toxicity

(850.1400)	Waived	47451404

Avian Dietary Toxicity

(850.2200)	Waived	47451404

Avian Reproduction

(850.2300)	Waived	47451404

Aquatic Plant Toxicity

(850.4400)	Waived	47451404

Algal Toxicity

(850.5400)	Waived	47451404

Nontarget insect testing

(850.4350)	Waived	47451404

VIII.    GLOSSARY OF ACRONYMS AND ABBREVIATIONS

BPPD	Biopesticides and Pollution Prevention Division

BRAD	Biopesticide Registration Action Document

CFR	Code of Federal Regulations

cm3 	cubic centimeter

CSF	Confidential Statement of Formula

°C 	degrees Celsius

EDSP	Endocrine Disruptor Screening Program

EDSTAC	Endocrine Disruptor Screening and Testing Advisory Committee

EPA	Environmental Protection Agency (the “Agency”)

FFDCA	Federal Food, Drug, and Cosmetic Act

FIFRA	Federal Insecticide, Fungicide, and Rodenticide Act

FQPA 	Food Quality Protection Act

FR	Federal Register

g 	gram

kg	kilogram

L                  liter

LD50	median lethal dose. A statistically derived single dose that can be
expected 

	to cause death in 50% of the test animals when administered by the
route 

	indicated (oral, dermal, or inhalation). It is expressed as a weight of

	substance per unit weight of animal (e.g., mg/kg).

MRID No.	Master Record Identification Number

mg	milligram

mL	milliliter

MP	manufacturing-use product

MPCA	microbial pest control agent

NE	“No Effect”

NIOSH 	National Institute for Occupational Safety and Health

OPP	Office of Pesticide Programs

OPPTS 	Office of Prevention, Pesticides, and Toxic Substances

PCR	polymerase chain reaction 

PPE 	personal protective equipment

TGAI 	technical grade of the active ingredient

IX.		 Appendix B.

For product specific information, please refer to   HYPERLINK
"http://www.epa.gov/pesticides/pestlabels" 
http://www.epa.gov/pesticides/pestlabels 

X.	       Appendix C.

REFERENCES

MRID 47451401.	 Smith, C.  June 13, 2008.  Calcium Acetate: Product
Identity, Composition and Analysis.

MRID 47451402. Smith, C.  June 13, 2008.   Calcium Acetate: Color,
Physical, State, Odor, Stability, UV/Visible Lights Absorption, Melting
Point, Density, Dissociation Constant, Partition Coefficient, Water
Solubility and Vapor

MRID 47451403.  Smith, C. June 13, 2008.  Calcium Acetate:  pH.

MRID 47451404.  Smith, C. June 13, 2008.  Calcium Acetate (TGAI) &
Disposable Bull Run Yellow jacket Trap E.  Environmental Fate & Effects
on Non target organisms.

MRID 47451405.  Smith, C. June 13, 2008. Calcium Acetate (TGAI)
Mammalian Toxicology.

Calcium Acetate	Page   PAGE  3  of   NUMPAGES  15 

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