Document ID: EPA-HQ-OPPT-2002-0054-0269
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2002-11-22T05:00Z

STATUTORY
MEMBERS
Council
on
Environmental
Quality
Department
of
Commerce
Environmental
Protection
Agency
National
Cancer
Institute
National
Institute
of
Environmental
Health
Sciences
National
Institute
for
Occupational
Safety
and
Health
National
Science
Foundation
Occupational
Safety
and
Health
Administration
Dr.
Scott
A.
Masten
Chairperson
Dr.
Mark
Toraason
Vice
Chairperson
TSCA
INTERAGENCY
TESTING
COMMITTEE
U.
S.
EPA/
OPPT
(
7401M)
ICC
Building,
Room
5353
1200
Pennsylvania
Avenue,
NW
Washington,
DC
20460
LIAISON
MEMBERS
Agency
for
Toxic
Substances
and
Disease
Registry
Consumer
Product
Safety
Commission
Department
of
Agriculture
Department
of
Defense
Department
of
the
Interior
Food
and
Drug
Administration
National
Library
of
Medicine
National
Toxicology
Program
Dr.
John
D.
Walker,
Ph.
D.,
M.
P.
H.
Director
Ms.
Norma
S.
L.
Williams
Executive
Assistant
Telephone
(
202)
564­
7527
Fax
(
202)
564­
7528
Email:
williams.
norma@
epa.
gov
The
TSCA
Interagency
Testing
Committee
(
ITC)
(
http://
www.
epa.
gov/
opptintr/
itc/)
is
providing
a
response
to
a
question
from
OMB/
SBA.

Question:
What
programs
support
the
need
for
including
inorganic
chemicals
in
the
Inventory
Update
Rules
(
IURs)?

Answer:
The
ITC
supports
the
need
for
including
inorganic
chemicals
in
the
Inventory
Update
Rule.
The
ITC
is
an
independent
advisory
committee
to
the
U.
S.
EPA
Administrator
that
was
created
in
1976
under
section
4(
e)
of
the
Toxic
Substances
Control
Act
(
TSCA).
Sixteen
(
16)
U.
S.
Government
organizations
are
ITC
Members,
including
the
Agency
for
Toxic
Substances
and
Disease
Registry
(
ATSDR),
Council
on
Environmental
Quality
(
CEQ),
Consumer
Product
Safety
Commission
(
CPSC),
Department
of
Agriculture
(
USDA),
Department
of
Defense
(
DOD),
Food
and
Drug
Administration
(
FDA),
Department
of
the
Interior
(
DOI),
U.
S.
Environmental
Protection
Agency
(
U.
S.
EPA),
Department
of
Commerce
(
DOC),
National
Cancer
Institute
(
NCI),
National
Institute
of
Environmental
Health
Sciences
(
NIEHS),
National
Institute
for
Occupational
Safety
and
Health
(
NIOSH),
National
Library
of
Medicine
(
NLM),
National
Science
Foundation
(
NSF),
National
Toxicology
Program
(
NTP)
and
Occupational
Safety
and
Health
Administration
(
OSHA).

Members
from
these
U.
S.
Government
organizations
nominate
chemicals
to
the
ITC
when
their
organizations
need
data
that
can
be
obtained
under
TSCA
using
ITC
and
U.
S.
EPA
authority.
These
include
unpublished
production
volume,
use,
exposure,
monitoring,
environmental
fate,
ecological
effects
and
health
effects
data.
The
ITC
meets
monthly
to
determine
if
chemicals
with
U.
S.
Government
data
needs
should
be
added
to
the
Priority
Testing
List
and
recommended
for
testing
or
information
reporting
in
Federal
Register
(
FR)
Reports
to
the
Administrator
every
May
and
November.

ITC's
use
of
IUR
The
ITC
is
probably
the
most
consistent
and
largest
user
of
data
produced
from
the
IURs.
The
ITC's
dependence
on
production
and
importation
volume
data
and
trends
is
well
known
and
reflected
in
numerous
strategies
to
identify
chemicals
and
classes
of
chemicals
(
Walker,
1993,
1995;
Walker
and
Brink,
1989).
With
the
exception
of
antimony
compounds,
organotins
and
metal
naphthenates,
the
ITC
routinely
has
to
defer
recommending
classes
of
inorganic
chemicals
for
testing
or
information
reporting
because
of
the
paucity
of
reliable
(
see
comment
on
reliability
below)
production
and
importation
volume
data.
A
recent
example
illustrates
how
the
paucity
of
production
and
importation
volume
data
influences
which
chemicals
and
classes
of
chemicals
the
ITC's
recommends
for
testing
or
information
reporting
and
which
chemicals
and
classes
of
chemicals
are
then
assessed
for
exposure,
hazard
or
risk.

In
September
1991,
OSHA
presented
a
list
of
658
chemical
substances
and
mixtures
(
its
Z­
1­
A
Table
in
54
FR
2332­
2983)
to
the
ITC
to
assess
the
availability
of
dermal
absorption
data
and
the
need
for
testing
that
could
be
recommended
under
TSCA.
The
ITC
reviewed
the
list
and
determined
that
a
number
of
polymers,
pesticides,
complex
mixtures,
and
chlorofluorocarbons
(
CFCs)
were
not
suitable
candidates
for
consideration
because
they
were
not
suitable
for
testing,
were
regulated
under
other
Federal
authorities,
or
were
not
regulable
under
TSCA.
The
remaining
chemicals
were
divided
into
2
groups
based
on
production
volume:
greater
or
less
than
1
million
pounds,
based
on
the
1990
IUR
data.
All
inorganic
chemicals
and
classes
of
inorganic
chemicals
were
assigned
to
the
"
less
than
1
million
pounds"
group
because
there
were
no
IUR
data
on
which
to
determine
production
volume
and
make
testing
recommendations
(
Walker
et
al.,
1996).

References
Walker,
J.
D.
and
R.
H.
Brink.
1989.
New
cost­
effective,
computerized
approaches
to
selecting
chemicals
for
priority
testing
consideration.
pp.
507­
536.
In
G.
W.
Suter,
II
and
M.
A.
Lewis
(
eds.),
Aquatic
Toxicology
and
Environmental
Fate:
Eleventh
Volume,
ASTM
STP
1007.
ASTM,
Philadelphia,
PA.

Walker,
J.
D.
1991.
Chemical
selection
by
the
TSCA
Interagency
Testing
Committee:
use
of
computerized
substructure
searching
to
identify
chemical
groups
for
health
effects,
chemical
fate
and
ecological
effects
testing.
The
Science
of
the
Total
Environment
109/
110:
691­
700.

Walker,
J.
D.
1995.
Estimation
methods
used
by
the
TSCA
Interagency
Testing
Committee
to
prioritize
chemicals
for
testing:
Exposure
and
biological
effects
scoring
and
structure
activity
relationships.
Toxicology
Modeling
1:
123­
141.

Walker,
J.
D.
C.
Whittaker
and
J.
N.
McDougal.
1996.
Role
of
the
TSCA
Interagency
Testing
Committee
in
meeting
the
U.
S.
Government's
data
needs:
Designating
chemicals
for
percutaneous
absorption
testing.
pp.
371­
381.
In
F.
Marzulli
and
H.
Maibach
(
eds).
Dermatoxicology.
Taylor
&
Francis,
Washington,
DC.