Document ID: EPA-HQ-OPP-2002-0249-0010
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2002-10-01T04:00Z

MEMORANDUM
7/
29/
2001
SUBJECT:
Residue
Chemistry
Chapter
For
The
Diuron
Reregistration
Eligibility
Decision
(
RED)
Document.

DP
Barcode:
D274492
Chemical
No.
035505
Case
No:
0046
FROM:
John
S.
Punzi,
Ph.
D.,
Chemist
(
Signed
8/
7/
2001)
Reregistration
Branch
2
Health
Effects
Division
[
7509C]

THRU:
Alan
Nielsen,
Branch
Senior
Scientist
Reregistration
Branch
2
Health
Effects
Division
[
7509C]

TO:
Diana
Locke,
Ph.
D.,
Risk
Assessor
Reregistration
Branch
2
Health
Effects
Division
[
7509C]

Attached
is
the
Residue
Chemistry
Chapter
for
the
Diuron
Reregistration
Eligibility
Decision
(
RED)
document.
This
chapter
was
completed
by
the
Dynamac
Corporation
under
supervision
of
HED
and
has
undergone
secondary
review/
modification
in
Reregistration
Branch
2
for
consistency
with
current
EPA
policies.
This
document
was
reviewed
by
the
ChemSac
on
7/
25/
01
and
recommendations
have
been
incorporated.

The
existing
residue
chemistry
database
is
incomplete.

Label
revisions
are
required
for
many
crops
in
order
to
reflect
the
parameters
of
use
patterns
for
which
residue
data
are
available.
Many
of
the
revisions
concern
retreatment
intervals,
Preharvest
intervals
(
PHI's)
and
rotational
crop
restrictions.

The
qualitative
nature
of
the
residue
of
diuron
in
plants
and
animals
has
been
adequately
identified/
characterized.
The
Agency
is
recommending
that
the
tolerance
expression
for
diuron
be
revised
to
include
metabolites
hydrolyzable
to
3,4­
dichloroaniline.

Adequate
analytical
methods
exist
for
data
collection
and
tolerance
enforcement
in
plants.
Independent
laboratory
validation
of
the
enforcement
method
is
required
for
livestock
methods
prior
to
Agency
validation.
Multiresidue
methods
for
diuron
and
metabolites
of
toxic
concern
are
required
for
plants
and
livestock.

Adequate
storage
stability
data
are
available
for
many
supported
crops.

Results
from
animal
feeding
studies
suggest
that
tolerances
are
necessary
for
poultry
or
egg
commodities
and
for
meats
and
milk.
Residue
data
are
not
available
for
several
potential
feed
items.
If
the
maximum
dietary
burden
does
not
increase
when
recalculated
from
all
potential
feed
items
after
acceptable
field
trial
data
are
submitted
then
the
established
tolerances
for
residues
in
fat,
meat,
and
meat
byproducts
of
cattle,
goats,
hogs,
horses,
and
sheep
can
be
lowered.

Adequate
residue
data
exist
for
some
processed
food/
feed
commodities.

The
reregistration
requirements
for
magnitude
of
the
residue
in
plants
are
not
fulfilled
for:
alfalfa
forage;
globe
artichoke;
barley
hay;
cotton
gin
byproducts;
field
corn
aspirated
grain
fractions;
field
corn
forage
and
stover;
filbert;
grass
forage,
hay,
seed
screenings,
and
straw;
lemon;
pear;
oat
forage,
hay;
olive;
field
pea
vines
and
hay;
sorghum
aspirated
grain
fractions,
stover,
and
forage;
wheat
forage
and
hay.
Additional
crop
field
trial
data
are
required
for
these
commodities.

The
reregistration
requirements
for
magnitude
of
the
residue
in
plants
are
fulfilled
for:
alfalfa
hay;
apple;
asparagus;
banana;
barley
grain,
straw;
blackberry;
blueberry;
clover
forage
and
hay;
field
corn
grain;
popcorn
grain
and
popcorn
stover;
cotton
seed;
gooseberry;
grape;
grapefruit;
loganberry;
macadamia
nut;
oat
grain
and
straw;
orange;
papaya;
field
pea
seed;
peach;
pecan;
peppermint;
pineapple;
raspberry;
sorghum
grain;
sugarcane;
trefoil
forage
and
hay;
vetch
forage
and
hay;
walnut;
and
wheat
grain,
aspirated
grain
fractions,
and
straw.
Adequate
field
trial
data
depicting
diuron
residues
of
concern
following
applications
made
according
to
the
maximum
registered
use
patterns
have
been
submitted
for
these
commodities
or
data
have
been
translated
from
appropriate
crops.

The
registrants
have
indicated
that
a
Section
3
tolerance
for
diuron
in/
on
catfish
is
desired.
Since
the
metabolism
committee
is
concerned
with
a
monochloronated
diuron
metabolite
identified
in
water,
a
metabolism
study
of
diuron
in
fish
is
required.
The
registrants
are
directed
to
OPPTS
860.1400
for
study
guidelines
and
encouraged
to
submit
a
study
protocol
prior
to
initiating
the
study.

Field
rotational
crop
trials
have
been
conducted
on
representative
crops
at
less
that
the
maximum
application
rates
with
1
year
plant
back
intervals
and
some
labels
indicate
a
2
year
plant
back
interval.
RRB2
recommends
that
the
registrants
provide
additional
data
to
support
the
higher
application
rate
and
believes
that
the
2­
yr
PBI
is
not
practical.
The
registrants
should
remove
the
2­
yr
PBI
from
the
registered
uses
and
provide
data
to
support
the
3.2
lb
ai/
A
application
rate
and
1­
yr
PBI.
Until
adequate
data
are
supplied
labels
should
be
amended
to
restrict
rotational
crops
to
those
crops
which
currently
are
registered
as
primary
crops..

cc:
JSPunzi
(
RRB2),
Diuron
Reg.
Std.
File,
Diuron
SF,
RF,
LAN.
7509C:
RRB2:
John
S.
Punzi:
CM2:
Rm
712M:
703­
305­
7727:
07/
29/
2000.

Diuron
PC
Code
035505;
Case
0046
DP
Barcode
D274492
Reregistration
Eligibility
Decision;
Residue
Chemistry
Considerations
May
29,
2001
Contract
No.
68­
W­
99­
053
Submitted
to:
U.
S.
Environmental
Protection
Agency
Arlington,
VA
Submitted
by:
Dynamac
Corporation
The
Dynamac
Building
2275
Research
Boulevard
Rockville,
MD
20850­
3268
DIURON
REREGISTRATION
ELIGIBILITY
DECISION
RESIDUE
CHEMISTRY
CONSIDERATIONS
PC
Code
035505;
Case
0046
(
DP
Barcode
D274492)

TABLE
OF
CONTENTS
page
INTRODUCTION
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1
REGULATORY
BACKGROUND
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1
SUMMARY
OF
SCIENCE
FINDINGS
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2
GLN
860.1200:
Directions
for
Use
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2
GLN
860.1300:
Nature
of
the
Residue
­
Plants
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29
GLN
860.1300:
Nature
of
the
Residue
­
Livestock
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30
GLN
860.1340:
Residue
Analytical
Methods
­
Plants
and
Livestock
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32
GLN
860.1360:
Multiresidue
Methods
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33
GLN
860.1380:
Storage
Stability
Data
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33
Plant
commodities
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33
Livestock
commodities
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34
GLN
860.1500:
Crop
Field
Trials
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34
Legume
Vegetables
Group
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35
Pea,
field,
seed
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35
Foliage
of
Legume
Vegetables
Group
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35
Pea,
field,
vines
and
hay
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35
Citrus
Fruit
Group
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36
Grapefruit
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36
Lemon
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36
Orange
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36
Pome
Fruit
Group
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36
Apple
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36
Pear
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36
Stone
Fruit
Group
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37
Peach
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37
Berry
Group
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37
Blackberry
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37
Blueberry
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37
Gooseberry
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37
Loganberry
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37
Table
of
Contents
(
continued)
page
v
Raspberry
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37
Tree
Nut
Group
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38
Filbert
.
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.
38
Macadamia
nut
.
.
.
.
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.
.
.
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.
38
Pecan
.
.
.
.
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.
38
Walnut
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
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.
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.
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.
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.
.
38
Cereal
Grains
Group
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
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.
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.
.
.
.
.
.
.
38
Barley,
grain
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
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.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
38
Corn,
field,
grain
and
aspirated
grain
fractions
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
38
Corn,
pop,
grain
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
39
Corn,
sweet,
K+
CWHR
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
39
Oat,
grain
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
39
Sorghum,
grain
and
aspirated
grain
fractions
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
39
Wheat,
grain
and
aspirated
grain
fractions
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
39
Forage,
Fodder,
and
Straw
of
Cereal
Grains
Group
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
40
Barley,
hay
and
straw
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
40
Corn,
field,
forage
and
stover
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
40
Corn,
pop,
stover
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
40
Corn,
sweet,
forage
and
stover
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
40
Oat,
forage,
hay,
and
straw
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
40
Sorghum,
forage
and
stover
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
40
Wheat,
forage,
hay,
and
straw
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
41
Grass
Forage,
Fodder,
and
Hay
Group
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
41
Grass,
forage,
hay,
seed
screenings,
and
seed
straw
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
41
Nongrass
Livestock
Feeds
(
Forage,
Fodder,
Hay,
and
Straw)
Group
.
.
.
.
.
.
.
.
.
.
.
.
.
42
Alfalfa,
forage
and
hay
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
42
Clover,
forage
and
hay
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
42
Trefoil,
forage
and
hay
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
42
Vetch,
forage
and
hay
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
42
Miscellaneous
Commodities
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
43
Artichoke,
globe
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
43
Asparagus
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
43
Banana
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
43
Cotton,
seed
and
gin
byproducts
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
43
Grape
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
44
Olive
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
44
Papaya
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
44
Peppermint
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
44
Pineapple
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
45
Sugarcane
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
45
Table
of
Contents
(
continued)
page
vi
GLN
860.1520:
Processed
Food/
Feed
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
45
Apple
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
45
Barley
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
45
Citrus
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
46
Corn,
field
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
46
Cottonseed
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
46
Grape
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
46
Mint
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
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.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
46
Oats
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
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.
.
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.
.
.
.
.
.
.
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.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
46
Olive
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
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.
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.
.
.
.
.
.
.
46
Pineapple
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
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.
.
.
.
.
.
.
.
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.
.
.
.
.
.
.
.
.
.
.
46
Sugarcane
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
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.
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.
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.
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.
.
.
.
.
.
.
.
.
47
Wheat
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
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.
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.
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.
.
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.
.
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.
.
.
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.
.
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.
.
.
.
.
.
.
.
.
.
.
.
47
GLN
860.1480:
Meat,
Milk,
Poultry,
and
Eggs
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
47
GLN
860.1400:
Water,
Fish,
and
Irrigated
Crops
.
.
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.
49
GLN
860.1460:
Food
Handling
.
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.
50
GLN
860.1850
and
860.1900:
Confined/
Field
Accumulation
in
Rotational
Crops
.
.
.
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.
.
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.
50
TOLERANCE
REASSESSMENT
SUMMARY
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60
Tolerances
Listed
Under
40
CFR
§
180.106(
a)
.
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.
60
Tolerances
To
Be
Proposed
Under
40
CFR
§
180.106(
a)
.
.
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61
Tolerances
Listed
Under
40
CFR
§
180.106(
b)
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61
Tolerances
To
Be
Proposed
Under
40
CFR
§
180.106(
c)
.
.
.
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61
Pending
Tolerance
Petitions
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61
INTERNATIONAL
HARMONIZATION
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68
AGENCY
MEMORANDA
RELEVANT
TO
REREGISTRATION
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69
MASTER
RECORD
IDENTIFICATION
NUMBERS
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77
DIURON
REREGISTRATION
ELIGIBILITY
DECISION
RESIDUE
CHEMISTRY
CONSIDERATIONS
PC
Code
035505;
Case
0046
INTRODUCTION
Diuron
[
3­(
3,4­
dichlorophenyl)­
1,1­
dimethylurea]
is
an
herbicide
currently
registered
for
use
on
a
variety
of
fruit,
vegetable,
nut,
and
field
crops
including
alfalfa,
apple,
artichoke,
asparagus,
banana
and
plantain,
winter
barley,
bermudagrass,
blueberry,
caneberry,
citrus,
red
clover,
field
corn,
cotton,
filbert,
gooseberry,
grape,
grass
seed
crops,
macadamia
nut,
oats,
olive,
papaya,
field
pea,
peach,
pear,
pecan,
peppermint,
pineapple,
grain
sorghum,
sugarcane,
trefoil,
walnut,
and
winter
wheat.

The
reregistration
of
diuron
is
being
supported
by
Griffin
Corporation,
E.
I.
du
Pont
de
Nemours
and
Company,
Drexel
Chemical
Company,
and
Aventis
CropScience
USA.
The
diuron
formulation
classes
registered
to
these
companies
for
food/
feed
uses
include
the
wettable
powder
(
WP),
emulsifiable
concentrate
(
EC),
dry
flowable
(
DF),
and
flowable
concentrate
(
FlC).
These
formulations
are
typically
applied
as
preplant,
preemergence,
soil
directed,
or
postemergence
treatments
using
ground
or
aerial
equipment.

REGULATORY
BACKGROUND
Diuron
was
the
subject
of
a
Reregistration
Standard
Guidance
Document
dated
9/
83;
the
Residue
Chemistry
Science
Chapter
of
the
Guidance
Document
was
dated
6/
25/
82.
The
Residue
Chemistry
Chapter
Update
of
the
Diuron
Reregistration
Standard
was
issued
on
3/
9/
92.
These
documents
summarized
the
available
residue
chemistry
data
and
specified
reregistration
requirements
in
support
of
food/
feed
uses.
Several
data
submissions
have
been
received
and
evaluated
since
the
Update.
The
information
contained
in
this
document
outlines
the
Residue
Chemistry
Science
Assessments
with
respect
to
the
reregistration
of
diuron.
We
note
that
although
Du
Pont
was
the
primary
registrant
of
diuron
when
the
Update
was
issued,
Du
Pont
has
since
transferred,
cancelled,
or
substantially
reduced
its
registered
uses
of
diuron;
Griffin
LLC
is
now
the
primary
registrant
of
diuron,
and
is
taking
the
lead
in
a
data
sharing
agreement
with
the
other
diuron
registrants.

Diuron
has
been
classified
as
a
"
known/
likely"
human
carcinogen
by
all
routes.

Tolerances
for
residues
of
diuron
in/
on
plant
and
livestock
commodities
are
established
under
40
CFR
§
180.106.
Diuron
tolerances
are
expressed
as
diuron
per
se.
HED
is
now
recommending
that
the
tolerance
expression
for
diuron
be
revised
to
include
metabolites
hydrolyzable
to
3,4­
dichloroaniline
(
3,4­
DCA).
This
determination
is
based
on
the
results
of
the
reviewed
plant
and
livestock
metabolism
2
1.
Date
of
the
most
recently
EPA­
approved
label
found
in
the
Pesticide
Product
Label
System
(
PPLS).

2.
This
product
is
a
multiple­
active­
ingredient
(
MAI)
product,
containing
thidiazuron
at
1
lb/
gal.

3.
This
product
is
an
MAI
product,
containing
thidiazuron
at
50%.

4.
This
product
is
an
MAI
product,
containing
bromacil
at
40%.

5.
Including
SLN
LA980002.

6.
Including
SLN
LA980003
and
TX000011.

7.
Including
SLN
OR950032.
studies.
Adequate
residue
analytical
methods
are
available
for
determination
of
diuron
total
toxic
residues.

GLN
860.1200:
Directions
for
Use
A
search
of
the
Agency's
REFS
database,
conducted
on
2/
8/
01,
identified
seven
active
diuron
end­
use
products
(
EPs)
registered
to
diuron
data
submitters
under
FIFRA
Section
3
for
use
on
food/
feed
crops.
These
EPs,
including
the
associated
Special
Local
Need
(
SLN)
registrations
under
FIFRA
Section
24
(
c),
are
listed
in
Table
A1.

Table
A1.
Diuron
EPs
with
Food/
Feed
Uses
Registered
to
Diuron
Data
Submitters.

EPA
Reg.
No.
Label
Acceptance
Date1
Formulation
Product
Name
Aventis
CropScience
USA
264­
634
4/
14/
98
0.5
lb/
gal
EC2
Ginstar
®
EC
Cotton
Defoliant
264­
661
6/
18/
96
25%
WP3
Dropp
®
Ultra
Cotton
Defoliant
E.
I.
du
Pont
de
Nemours
and
Co.

352­
505
7/
1/
99
40%
DF4
Krovar
®
I
DF
Herbicide
Griffin
Corporation
1812­
2575
3/
15/
01
4
lb/
gal
FlC
Direx
4L
®
Herbicide
1812­
3626
3/
15/
01
80%
DF
Karmex
®
DF
Herbicide
Drexel
Chemical
Company
19713­
36
3/
15/
01
4
lb/
gal
FlC
Diuron
4L
Herbicide
19713­
2747
11/
30/
00
80%
WP
Diuron
80
Herbicide
A
comprehensive
summary
of
diuron
food/
feed
use
patterns,
based
on
the
registered
product
labels
of
the
diuron
data
submitters,
is
presented
in
Table
A2.
A
tabular
summary
of
the
residue
chemistry
science
assessments
for
reregistration
of
diuron
is
presented
in
Table
B.
The
status
of
reregistration
requirements
for
each
guideline
topic
listed
in
Table
B
3
is
based
on
the
use
patterns
registered
to
the
members
of
the
Diuron
Task
Force,
the
basic
registrants.
When
end­
use
product
DCIs
are
developed
(
e.
g.,
at
issuance
of
the
RED),
RD
should
require
that
all
end­
use
product
labels
(
e.
g.,
MAI
labels,
SLNs,
and
products
subject
to
the
generic
data
exemption)
be
amended
such
that
they
are
consistent
with
the
labels
of
the
basic
registrants.

For
the
purpose
of
generating
this
Residue
Chemistry
Chapter,
the
Agency
compared
the
diuron
food/
feed
uses
currently
registered
to
Griffin,
Drexel,
Du
Pont,
and
Aventis
(
Table
A2)
with
the
available
crop
field
trial
data.
As
a
result,
label
amendments
are
required
for
some
formulations,
as
specified
below.

For
apple,
the
label
for
the
4
lb/
gal
FlC
[
EPA
Reg.
No.
19713­
36]
formulation
must
be
amended
to
correct
an
apparent
typographical
error.
The
label
currently
states
"
Apply
4
pounds
per
acre
in
the
Spring;"
this
should
be
modified
to
state
"
Apply
3.2
quarts
per
acre
in
the
Spring."
Once
corrected,
the
maximum
application
rate
for
apples
will
be
3.2
lb
ai/
A,
which
is
the
maximum
rate
supported
by
available
field
trial
data.

For
banana,
the
labels
for
the
4
lb/
gal
FlC
[
EPA
Reg.
Nos.
1812­
257
and
19713­
36],
80%
DF
[
EPA
Reg.
No.
1812­
362]
and
80%
WP
[
EPA
Reg.
No.
19713­
274]
formulations
must
be
modified
to
specify
that
application
may
only
be
made
to
bananas
grown
in
HI.

For
citrus
fruits,
the
product
labels
for
the
4
lb/
gal
FlC
[
EPA
Reg.
Nos.
1812­
257
and
19713­
36],
40%
DF
[
EPA
Reg.
No.
352­
505],
80%
DF
[
EPA
Reg.
No.
1812­
362]
and
80%
WP
[
EPA
Reg.
No.
19713­
274]
formulations
must
be
modified
to
specify
the
following
maximum
seasonal
application
rates:
6.4
lb
ai/
A
for
FL
and
PR,
and
3.2
lb
ai/
A
for
all
other
areas.

For
corn,
the
labels
for
the
4
lb/
gal
FlC
[
EPA
Reg.
Nos.
1812­
257
and
19713­
36],
80%
DF
[
EPA
Reg.
No.
1812­
362],
and
80%
WP
[
EPA
Reg.
No.
19713­
274]
formulations
must
be
amended
to
make
it
clear,
under
the
use
directions
for
"
Corn
(
field)"
that
application
is
only
to
be
made
to
field
corn
or
popcorn.

For
cotton,
the
labels
for
the
4
lb/
gal
FlC
[
EPA
Reg.
Nos.
1812­
257
and
19713­
36],
80%
DF
[
EPA
Reg.
No.
1812­
362],
and
80%
WP
[
EPA
Reg.
No.
19713­
274]
formulations
must
be
amended
to
remove
the
maximum
seasonal
rate
for
application
to
cotton
in
loamy
sand
soils
because
the
labels
also
state
that
application
should
not
be
made
to
loamy
sand
soils.

For
cotton,
the
labels
for
the
25%
WP
[
EPA
Reg.
No.
264­
661]
and
0.5
lb/
gal
EC
[
EPA
Reg.
No.
264­
634]
formulations
must
be
modified
to
remove
the
restriction
against
the
feeding
of
cotton
gin
byproducts
to
livestock.
The
Agency
does
not
believe
that
this
restriction
is
practical.

For
grass
seed
crops,
current
product
labels
allow
application
at
up
3.2
lb
ai/
A
in
the
fall
or
up
to
2.4­
3.2
lb
ai/
A
in
the
spring
(
depending
on
geographical
location).
No
data
reflecting
spring
application
at
4
2.4­
3.2
lb
ai/
A
are
available.
The
registrants
must
modify
product
labels
to
specify
a
maximum
application
rate
of
1.6
lb
ai/
A
for
spring
applications.
Alternatively,
crop
field
trial
data
reflecting
spring
application
at
2.4­
3.2
lb
ai/
A
may
be
submitted.

For
winter
wheat,
the
labels
for
the
4
lb/
gal
FlC
[
EPA
Reg.
No.
1812­
257]
and
the
80%
DF
[
EPA
Reg.
No.
1812­
362]
formulations
must
be
modified.
The
heading
"
Other
Areas
of
Oregon
and
Washington"
should
be
modified
to
state
"
Other
Areas."

The
products
labels
for
EPA
Reg.
Nos.
19713­
36
and
19713­
274
include
use
directions
for
Bermudagrass.
The
use
of
diuron
on
Bermudagrass
is
not
supported
by
field
trial
data
or
any
tolerances.
Tolerances
for
diuron
residues
in
Bermudagrass
forage
and
hay
had
previously
been
established;
however,
these
tolerances
were
revoked
in
1998.
The
use
directions
for
Bermudagrass
must
be
removed
from
the
product
labels
for
EPA
Reg.
Nos.
19713­
36
and
19713­
274.

SLN
CA850060
is
associated
with
EPA
Reg.
No.
254­
247,
a
diuron
product
that
was
canceled
in
1996.
In
addition,
the
use
on
SLN
CA850060
is
a
use
on
lakes,
ponds,
holding
basins,
and
other
similar
sites
which
may
be
used
for
irrigation.
No
data
to
support
these
uses
are
available;
therefore,
SLN
CA850060
should
be
canceled.

Rotational
crop
restrictions
should
be
made
consistent
between
various
formulations.
A
2­
year
plant
back
interval
may
not
be
practical
unless
phytotoxicity
is
a
concern.