Document ID: EPA-HQ-OPP-2008-0012-0025
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2008-03-26T04:00Z

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Triclocarban enhances testosterone action: a new type of endocrine
disruptor?

  HYPERLINK
"http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22C
hen%20J%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Results
Panel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"  Chen J ,   HYPERLINK
"http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22A
hn%20KC%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Results
Panel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"  Ahn KC ,   HYPERLINK
"http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22G
ee%20NA%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Results
Panel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"  Gee NA ,   HYPERLINK
"http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22A
hmed%20MI%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Resul
tsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"  Ahmed MI ,  
HYPERLINK
"http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22D
uleba%20AJ%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Resu
ltsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"  Duleba AJ ,  
HYPERLINK
"http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Z
hao%20L%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Results
Panel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"  Zhao L ,   HYPERLINK
"http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22G
ee%20SJ%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Results
Panel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"  Gee SJ ,   HYPERLINK
"http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22H
ammock%20BD%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Res
ultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"  Hammock BD ,  
HYPERLINK
"http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22L
asley%20BL%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Resu
ltsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus"  Lasley BL .

University of California, Center for Health and the Environment, Davis,
California 95616. bllasley@ucdavis.edu.

Many xenobiotics have been associated with endocrine effects in a wide
range of biological systems. These associations are usually between
small nonsteroid molecules and steroid receptor signaling systems. In
this report, triclocarban (TCC; 3,4,4'-trichlorocarbanilide), a common
ingredient in personal care products that is used as an antimicrobial
agent was evaluated and found to represent a new category of
endocrine-disrupting substance. A cell-based androgen receptor-mediated
bioassay was used to demonstrate that TCC and other urea compounds with
a similar structure, which have little or no endocrine activity when
tested alone, act to enhance testosterone (T)-induced androgen
receptor-mediated transcriptional activity in vitro. This amplification
effect of TCC was also apparent in vivo when 0.25% TCC was added to the
diet of castrated male rats that were supported by exogenous
testosterone treatment for 10 d. All male sex accessory organs increased
significantly in size after the T+TCC treatment, compared with T or TCC
treatments alone. The data presented here suggest that the bioactivity
of endogenous hormones may be amplified by exposure to commercial
personal care products containing sufficient levels of TCC.