Document ID: EPA-HQ-RCRA-2006-0984-0037
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2007-01-18T05:00Z

Provisional Toxicity Value Summary (PPRTV) for 

Dichloroethylene, cis-1,2- 

CAS: 000156-59-2 

 

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"http://chemfinder.cambridgesoft.com/result.asp?mol_rel_id=156-59-2" 
Chemical Information 

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Summary of PPRTV Information on-Line 

  

 

Subchronic and Chronic Toxicity

Chronic [RfD]:

  HYPERLINK "http://hhpprtv.ornl.gov/Dichloroethylenecis12.shtml" \l
"rc000156592#rc000156592"  on-Line PPRTV  

 

Subchronic [RfD]:

  HYPERLINK "http://hhpprtv.ornl.gov/Dichloroethylenecis12.shtml" \l
"rs000156592#rs000156592"  on-Line PPRTV  

 

Notes/Comments:

  HYPERLINK "http://hhpprtv.ornl.gov/Dichloroethylenecis12.shtml" \l
"c1000156592#c1000156592"  on-Line  

Carcinogenicity

EPA Group:

  HYPERLINK "http://hhpprtv.ornl.gov/Dichloroethylenecis12.shtml" \l
"epa000156592#epa000156592"  on-Line PPRTV  

Notes/Comments:

  HYPERLINK "http://hhpprtv.ornl.gov/Dichloroethylenecis12.shtml" \l
"c3000156592#c3000156592"  on-Line  

Subchronic and Chronic Toxicity (Other than Carcinogenicity)

 

Chronic [RfD]:

0.01 mg/kg/day 

This value has been externally peer-reviewed

Uncertainty Factor:

3000 

Confidence in Principle Study:

Low 

 

Subchronic [RfD]:

0.1 mg/kg-day 

This value has been externally peer-reviewed

Uncertainty Factor:

300 

Confidence in Principle Study:

Low 

 

Route:

Oral: gavage 

 

Target Organ / Critical Effect:

Blood / Onset of mild anemia changes 

 

Species

Effect Level

Dose

Experiment Length

Rat 

NOAEL 

32 mg/kg-day 

90 days 

 

References

2006 

U.S. EPA. 2006. Provisional Peer Reviewed Toxicity Values for
cis-1,2-Dichloroethylene (CASRN 156-59-2 ). 3-1-2006. 

Subchronic [RfC] Comments:

Data inadequate for deriving a subchronic RfC. 

Chronic [RfC] Comments:

Data inadequate for deriving a chronic RfC. 

Carcinogenicity

EPA Group<> 

IN 

References

2006 

U.S. EPA. 2006. Provisional Peer Reviewed Toxicity Values for
cis-1,2-Dichloroethylene (CASRN 156-59-2). 3-1-2006. 

EPA Group Comment:

Inadequate information to assess carcinogenic potential 

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Last updated on Wednesday, June 14th, 2006

URL: http://hhpprtv.ornl.gov/Dichloroethylenecis12.shtml