Document ID: EPA-HQ-OPP-2007-0350-0421
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2012-02-08T05:00Z

Appendix B.  Table of Generic Data Requirements and Studies Used to Make the Reregistration Decision for Chloropicrin (PC 081501)

GUIDE TO APPENDIX B

	Appendix B contains a listing of data requirements which support the reregistration for the active ingredient chloropicrin covered by this RED.  It contains generic data requirements that apply to chloropicrin in all products, including data requirements for which a "typical formulation" is the test substance.

The data table is organized in the following formats:

   1. Data requirement (Column 1).  The data requirements are listed in the order in which they appear in 40 CFR 158.  The reference numbers accompanying each test refer to the test protocols set in the Pesticide Assessment Guidance, which is available from the National Technical Information Service, 5285 Port Royal Road, Springfield, VA 22161.  (703) 487-4650.

   2. Use Pattern (Column 2).  This column indicates the use patterns for which the data requirements apply.  The following letter designations are used for the given use patterns.

         A.          Terrestrial food
         B. Terrestrial feed
         C. Terrestrial non-food
         D.          Aquatic food
         E. Aquatic non-food outdoor
         F. Aquatic non-food industrial
         G. Aquatic non-food residential
         H. Greenhouse food
         I. Greenhouse non-food
         J. Forestry
         K. Residential
         L. Indoor food
         M. Indoor non-food
         N. Indoor medical
         O. Indoor residential

3.  Bibliographic Citation (Column 3).  If the Agency has acceptable data in its files, this column lists the identifying number of each study.  This normally is the Master Record Identification (MRID) number, but may be a "GS" number is no MRID number has been assigned.  Refer to the Bibliography appendix for a complete citation of the study.
 

Data Requirement
Use Patterns
Citations
New Guideline Number
Old Guideline Number
Description

PRODUCT CHEMISTRY
830.1550
61-1
Product Identity and Composition
All
43090201, 43091301, 43091401  
830.1600
61-2A
Description of materials used to produce the product
All
44230001, 43090201, 43091301, 43091401, 42400001, 42400002
830.1620
61-2B
Description of production process
All
43090201, 43091301, 43091401, 42400001, 42400002
830.1650
61-2B
Description of formulation process
All
44230001
830.1670
61-2B
Formation of Impurities
All
43090201, 43091301, 43091401, 42400000
830.1700
62-1
Preliminary Analysis
All
43097901, 43137001, 43091402, 42400002
830.1750
62-2
Certification of Limits
All
43090202
830.1800
62-3
Analytical Method
All
43090202, 43137002, 43091402, 43137001
830.6302
63-2
Color
All
43097902, 43137002, 43133101, 42427001
830.6303
63-3
Physical State
All
43097902, 43137002, 43133101, 42427001
830.6304
63-4
Odor
All
42427001
830.6313
63-13
Stability to normal and elevated temperatures, metals, and metal ions
All
43097902, 43137002, 43133101, 42427001
830.6314
63-14
Oxidation/reduction: chemical incompatibility
All
43434601 
830.6315
63-15
Flammability
All
00013198
830.6317
63-17
Storage stability
All
00013198
830.6320
63-20
Corrosion characteristics
All
00013198
830.7100
63-18
Viscosity
All
43434601
830.7220
63-6
Boiling Point/boiling range
All
43097902, 43137002, 4313301, 42427001
830.7300
63-7
Density
All
43097902, 43137002, 43133101, 42427001
830.7505

Ultraviolet/visible Absorption
All
Study called in via the DCI, however EPA granted a waiver request in May 2011. 
830.7550
63-11
Partition coefficient, shake flask method
All
43022402, 43022402
830.7840
63-8
Solubility
All
43097902, 43137002, 43133101, 42427001
830.7860
63-8
Water solubility, generator column method
All
43097902, 43137002, 43133101, 42427001, 43613901
830.7950

63-9
Vapor Pressure
All
43097902, 43137002, 43133101, 42427001
ECOLOGICAL EFFECTS
850.1010
72-2   
Acute Toxicity to Freshwater Invertebrates
C, I 
130704 (supplemental), data gap submitted 48442401 in response to DCI 
850.1025
72-3B
Estuarine/Marine Toxicity  -  Mollusk
C, I
Data gap  -  submitted 48442404 in response to DCI
850.1035
72-3C
Estuarine/Marine Toxicity  -  Shrimp
C, I 
Data gap  -  submitted 48442403 in response to DCI
850.1075
72-1A
Fish Toxicity Bluegill
C, I
47102102 (supplemental)
850.1075
72-1 B
Fish Toxicity Rainbow Trout
C, I
47102102 (supplemental), 43066701(supplemental)
850.1075
72-3A
Estuarine/Marine Toxicity  -  Fish
C, I
Data gap  -  submitted 48442402, 48442405, 48442406 in response to DCI
850.3020
141-1

Honey bee acute contact LD50
C, I
Data gap  -  submitted 48442473 in response to DCI
850.4100
122-1
Seedling Emergence, Tier 1
C, I
Data gap  -  submitted 48442802 in response to DCI
850.4150
122-1
Vegetative Vigor, Tier 1
C, I
Data gap  -  submitted 48442802 in response to DCI
850.4400
123-2
Aquatic Plant Toxicity
C, I
Data gap  -  submitted 48442801 in response to DCI
Non-Guideline Study
Non-Guideline Study
Avian Acute Inhalation 
C, I 
Data gap  -  submitted 48442803 in response to DCI
TOXICOLOGY
870.1100
81-1
Acute Oral Toxicity - Rat
C, I
05014376
870.1200
81-2
Acute Dermal Toxicity  -  Rabbit/Rat
C, I
05014376
870.1300
81-3
Acute Inhalation Toxicity  -  Rat/Mouse
C, I
45117901, 45117902
870.2500
81-5
Primary Skin Irritation
C, I
05014376
870.3465
82-5
90- Day Inhalation Toxicity 
C, I
43063201
870.3465
82-4
13-Week Inhalation  -  Mouse/Rat 
C, I
43063201
870.3700A
83-3A
Developmental Toxicity  -  Rat
C, I
42740602
870.3700B
83-3B
Developmental Toxicity  -  Rabbit
C, I
42740601
870.3800
83-4
2-Generation Reproduction  -  Rat
C, I
43391901, 46427801
870.4100A
83-1
Chronic Toxicity Rodents
C, I
43744301
870.4100B
83-1B
Chronic Feeding Toxicity Study - Non-rodent
C, I
43196301
870.4200
83-2
Carcinogenicity - Rat
C, I
43632201, 05014915
870.4300
83-5
Combined Chronic Toxicity/Carcinogenicity: Rats
C, I
43755301
870.5100
84-2
Bacterial Reverse Mutation Test
C, I
41960801
870.5300
84-2
Mutagenic  - Lymphoma Mutation  -  Mouse
C, I
41960803
870.5375
84-2
Cytogenetis  -  CHO Chromosomal Aberrations
C, I
41960802
870.5395
84-2
Unscheduled DNA Synthesis-Rat
C, I
41960804
870.7800
85-7
Immunotoxicity
C, I
Study called in via the DCI, however EPA granted a waiver request in May 2011.
Non-guideline study
Non-guideline study
Acute Inhalation (human study) 
C, I
46443801
Non-guideline study
Non-guideline study
BMC concentration analysis
C, I
46614801
Non-guideline study
Non-guideline study
Quantification of the chemosensations produced from chloropicrin vapors
C, I
451178901
ENVIRONMENTAL FATE
835.1240
163-1
Leaching/Adsorption/Desorption
C, I
44191301
835.1410
163-2

Laboratory Volatilization (from Soil) Study
C, I
43798601
835.2120
161-1
Hydrolysis
C, I
43022401 
835.2240
161-2
Photodegradation - Water
C, I
42900201
835.2370
161-4
Photolysis Air
C, I
05007865
835.4100
162-1
Aerobic Soil Metabolism
C, I
43613901
835.4400
162-3
Anaerobic Aquatic Metabolism
C, I
43759301
835.6100
164-1
Terrestrial Field Dissipation
C, I
43085101
835.8100
163-3
Field Volatility (from soil) Study
C, I 
44149201, 47576901, 47295202, 47295203, 47295204, 45112902, 46420201, 45112901, 47456001, 47679301, 48033801, 48011601, 47820001, 47813801, 48006001, 48107601, 47813901, 47456001, 48087401, 47576901
OCCUPATIONAL AND RESIDENTIAL EXPOSURE
875.1300
232
Inhalation Exposure
C
44149201, 45112901 (data gap for EFED) 
875.2500
133-4
Inhalation (Passive Dosimetry) Exposure 
C
44149201, 45112901
OTHER-No Category
Special Study
NA
Fumigant Buffer Zone Posting Signs
C, I
Data gap satisfied May 2011
Special Study
NA
Community Outreach and Education Program
C, I
Data gap 
Special Study
NA
Certified Applicator Training
C, I
Data gap 
Special Study
NA
Safe Handler Information
C, I
Data gap satisfied 2010