Document ID: EPA-HQ-OPP-2003-0268-0004
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2003-07-30T04:00Z

[
D278615
/
Company
Code]
Dietary
exposure
assessment
/
1
[
Dinocap/
036001]

UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
November
7,
2001
MEMORANDUM
SUBJECT:
Dinocap.
(
Chemical
ID
No.
036001,
Case
No.
2200).
Acute
and
Chronic
Dietary
Exposure
Assessment
for
the
HED
Preliminary
Human
Health
Risk
Assessment;
PC
Code
036001;
DP
Barcode
No.
D278615;
Case
2200.

FROM:
Felecia
Fort,
Chemist
Reregistration
Branch
1
Health
Effects
Division
(
7509C)

THRU:
Whang
Phang,
Ph.
D.,
Branch
Senior
Scientist
Reregistration
Branch
1
Health
Effects
Division
(
7509C)

and
Jennifer
Tyler,
Chemist
Jose
Morales,
Chemist
Dietary
Exposure
Science
Advisory
Council
(
DE
SAC)
Health
Effects
Division
(
7509C)

TO:
Christina
Swartz
Reregistration
Branch
1
Health
Effects
Division
(
7509C)

and
Margaret
Rice
Reregistration
Branch
II
Special
Review
and
Reregistration
Division
(
7508W)
[
D278615
/
Company
Code]
Dietary
exposure
assessment
/
2
[
Dinocap/
036001]

2
EPA
Reviewer:
Felecia
Fort
,
Date
10/
18/
01
STUDY
TYPE:
Acute
and
Chronic
Dietary
Exposure
Assessments
ACTIVE
INGREDIENT:
Dinocap
SYNONYMS:
Trade
names
include
Arathane,
Caprane,
Capryl,
Cekucap
25
WP,
Crotonate,
Crotothane,
DCPC,
Dicap,
Dikar
(
a
mixture
of
dinocap
and
mancozeb),
DNOPC,
Ezenoan,
Iscothane,
Karathane,
Mildane,
and
Mildex.
Dinocap
(
PC
Code
036001)
is
the
common
name
for
a
mixture
of
2,4­
dinitro­
6­
octylphenyl
crotonate,
2,6­
dinitro­
4­
octylphenyl
crotonate,
and
nitrooctylphenols
(
principally
dinitro),
in
which
the
octyl
groups
are
a
mixture
of
1­
methylheptyl,
1­
ethylhexyl,
and
1­
propylpentyl
isomers.
The
other
two
active
ingredients
included
in
the
case,
which
pertain
to
specific
components
of
the
dinocap
mixture,
2,4­
dinitro­
6­
octylphenyl
crotonate
(
PC
Code
036002)
and
2,6­
dinitro­
4­
octylphenyl
crotonate
(
PC
Code
036003),
have
been
canceled.

ROC:
The
nature
of
the
residue
in
plants
and
animals
have
not
been
adequately
delineated.
The
current
tolerance
is
expressed
in
terms
of
combined
negligible
residues
of
a
fungicide
and
insecticide
that
is
a
mixture
of
2,4­
dinitro­
6­
octylphenyl
crotonate
and
2,6­
dinitro­
4­
octylphenyl
crotonate
in/
on
apples
and
grapes
at
0.1
ppm
[
40
CFR
§
180.341(
a)].

Executive
Summary
Acute
and
chronic
dietary
exposure
assessments
were
conducted
to
determine
the
dietary
exposure
estimates
associated
with
the
use
of
dinocap
in/
on
imported
grapes
and
apples
to
support
the
reregistration
eligibility
decision.

The
qualitative
nature
of
the
residue
in
plants
and
livestock
are
not
adequately
understood
and
no
acceptable
magnitude
of
the
residue
or
processing
data
in/
on
imported
apples
or
grapes
exist.
Therefore,
the
dietary
risk
assessment
was
conducted
two
ways,
using
the
current
tolerances
of
0.1
ppm
and
using
the
JMPR
MRLs
of
0.2
(
apples)
and
1
ppm
(
grapes).
The
JMPR
(
Joint
FAO/
WHO
Meeting
on
Pesticide
Residues)
proposes
maximum
residue
levels
(
MRLs)
for
individual
pesticides
in
different
food
and
feed
items,
and
provides
advice
on
the
acceptable
levels
of
pesticide
residues
in
food
moving
in
international
trade.

Partly
refined
Tier
2
acute
and
chronic
dietary
exposure
assessments
were
conducted
for
all
supported
dinocap
food
uses.
Dietary
risk
estimates
are
provided
for
the
general
U.
S.
population
and
various
population
subgroups.
This
assessment
shows
that
for
all
supported
registered
commodities,
irrespective
of
the
residue
data
used,
the
acute
risk
[
D278615
/
Company
Code]
Dietary
exposure
assessment
/
3
[
Dinocap/
036001]

1aPAD/
cPAD
=
acute/
chronic
Population
Adjusted
Dose
=
Acute
or
Chronic
RfD
FQPA
Safety
Factor
3
estimates
are
below
the
Agency's
level
of
concern
(<
100%
aPAD1)
at
the
99.9th
exposure
percentile
for
the
population
subgroup
of
concern,
females
13
­
50
years
old
(<
1%
of
the
aPAD).
This
assessment
also
shows
that
for
all
commodities,
the
chronic
risk
estimates
are
below
the
Agency's
level
of
concern
(<
100%
cPAD)
for
the
general
U.
S.
population
and
all
population
subgroups
(<
1%
of
the
cPAD).

I.
Introduction
Dietary
exposure
to
pesticides
can
occur
through
food,
water,
residential
and
occupational
means.
Risk
assessment
incorporates
both
exposure
and
toxicity
of
a
given
pesticide.
The
risk
is
expressed
as
a
percentage
of
a
dose
that
could
be
expressed
as
a
daily
or
a
long
term
dose,
to
pose
no
unreasonable
adverse
effects.
This
is
called
the
population
adjusted
dose
(
PAD),
and
is
expressed
as
%
PAD.
References
are
available
on
the
EPA/
pesticides
web
site
which
discuss
the
acute
and
chronic
risk
assessments
in
more
detail:
"
Available
Information
on
Assessing
Exposure
from
Pesticides,
A
User's
Guide",
6/
21/
2000,
web
link:
http://
www.
epa.
gov/
fedrgstr/
EPA­
PEST/
2000/
July/
Day­
12/
6061.
pdf
;
or
see
SOP
99.6,
8/
20/
99.

The
purpose
of
this
memorandum
is
to
summarize
the
results
of
the
dietary
risk
assessment
for
the
general
U.
S.
population
and
various
population
subgroups
resulting
from
exposure
to
dinocap
through
food.
This
dietary
exposure
assessment
is
the
first
risk
analysis
that
has
been
conducted
for
dinocap
and
was
conducted
using
the
Dietary
Exposure
Evaluation
Model
(
DEEM
 
)
software
Version
7.73
Toxicological
Information
The
doses
and
endpoints
for
dietary
exposure
assessment
selected
by
the
HED
Hazard
Identification
Assessment
Review
Committee
(
HIARC)
were
discussed
in
detail
in
the
P.
Chin
memorandum
dated
02/
23/
2000.
The
HIARC
established
an
acute
toxicity
endpoint
for
females
of
reproductive
age
(
females
13+
years
old)
and
determined
that
a
risk
assessment
for
acute
dietary
exposure
is
not
necessary
for
the
general
population.

The
FQPA
committee
recommended
that
the
FQPA
safety
factor
for
protection
of
infants
and
children
(
as
required
by
FQPA)
be
retained
at
10x
for
all
population
subgroups
when
assessing
acute
and
chronic
dietary
exposure.
The
reasons
are
(
1)
there
is
concern
for
the
quantitative
and
qualitative
increase
in
susceptibility
observed
in
fetuses
following
in
utero
exposure
in
the
prenatal
developmental
studies
in
mice
and
rabbit
and
(
2)
there
is
a
data
gap
for
the
developmental
neurotoxicity
study.
(
B.
Tarplee,
3/
25/
00).
[
D278615
/
Company
Code]
Dietary
exposure
assessment
/
4
[
Dinocap/
036001]

4
The
HED
RfD/
Peer
Review
Committee
(
HED
Doc.
No.
011076
dated
June
24,
1994)
evaluated
the
toxicology
data
of
dinocap
and
classified
it
as
a
Group
E
"
not
likely"
carcinogen.

The
doses
and
toxicological
endpoints
selected
for
dietary
exposure
scenarios
are
summarized
in
Table
1.

Table
1.
Summary
of
Endpoints
and
Doses
for
Dinocap.

EXPOSURE
SCENARIO
Population
DOSE
(
mg/
kg/
day)
RfD
PAD
(
mg/
kg/
day)
ENDPOINT
STUDY
Acute
Dietary
Female
13+
NOEL=
4
UF=
100
FQPA
SF
=
10
aRfD
=
0.04
aPAD
=
0.004
slight
(
non­
significant)
increase
in
incidences
of
cleft
palate
and
eyelids­
open
Developmental
 
mouse
General
population
none
none
N/
A
Chronic
Dietary
All
populations
NOEL=
0.375
UF=
100
FQPA
SF
=
10
cRfD
=
0.00375
cPAD
=
0.00038
ophthalmoscopic
changes
and
histologic
retinal
atrophy
Chronic
feeding
 
dog
Residue
Information
There
are
currently
no
registered
food/
feed
uses
of
dinocap
in
the
U.
S.
The
established
dinocap
tolerances
for
food
and
feed
commodities
have
been
revoked
except
for
those
for
apples
and
grapes.
Rohm
and
Haas
Company,
the
basic
producer,
intends
to
support
tolerances
for
dinocap
residues
in/
on
apples
and
grapes
to
permit
legal
importation
of
these
commodities
into
the
U.
S.

Tolerances
for
dinocap
are
currently
expressed
in
terms
of
combined
negligible
residues
of
a
fungicide
and
insecticide
that
is
a
mixture
of
2,4­
dinitro­
6­
octylphenyl
crotonate
and
2,6­
dinitro­
4­
octylphenyl
crotonate
in/
on
apples
and
grapes
at
0.1
ppm
[
40
CFR
§
180.341(
a)].
Current
U.
S.
tolerances
are
0.1
ppm
(
negligible)
on
both
crops
(
40
CFR
180.341).

Uses
of
dinocap
will
be
mainly
in
Europe,
the
Middle
East,
and
northern
Africa.
There
are
European
data
which
have
been
reviewed
by
the
Joint
FAO/
WHO
Meeting
on
Pesticide
Residues
(
JMPR).
The
JMPR
proposes
maximum
residue
levels
(
MRLs)
for
individual
pesticides
in
different
food
and
feed
items,
and
provides
advice
on
the
acceptable
levels
of
pesticide
residues
in
food
moving
in
international
trade.
Residues
of
dinocap
in
the
European
trials
were
<
0.05
(
ND)­
0.09
ppm
in
apples
and
<
0.05­
0.67
ppm
in
grapes.
JMPR
recommended
MRLs
of
0.2
and
1
ppm,
respectively.
These
values
have
not
been
adopted
because
of
acute
dietary
risk
concerns.
The
issue
is
to
be
addressed
in
2002.
The
MRLs
are
expressed
in
terms
of
dinocap
isomers
and
phenols,
expressed
as
dinocap.

The
qualitative
nature
of
the
residue
in
plants
and
livestock
are
not
adequately
understood.
No
[
D278615
/
Company
Code]
Dietary
exposure
assessment
/
5
[
Dinocap/
036001]

5
acceptable
magnitude
of
the
residue
or
processing
data
in/
on
imported
apples
or
grapes
exist.
Consequently,
the
dietary
risk
assessment
was
conducted
two
ways,
using
the
current
tolerances
of
0.1
ppm
and
using
the
JMPR
recommended
CODEX
MRLs
of
0.2
(
apples)
and
1
ppm
(
grapes).
No
processing
data
are
available;
therefore,
default
processing
factors
were
used.

The
Biological
and
Economic
Analysis
Division
(
BEAD)
provided
information
(
F.
Hernandez
email,
10/
17/
01)
on
the
percent
crop
treated
(%
CT)
[
Attachment
5].
For
the
chronic
analyses,
the
%
CT
is
entered
as
adjustment
factor
#
2
and
for
the
acute
analyses,
the
the
%
CT
is
incorporated
into
the
residue
value.
Less
than
5%
of
apples
or
grapes
are
imported,
and
less
than
1%,
of
those
5%
imported,
are
treated
which
results
in
a
%
CT
of
0.05.
This
%
CT
was
rounded
up
to
0.1%
in
the
dietary
assessment.

DEEM
 
Program
and
Consumption
Information
Dinocap
acute
and
chronic
dietary
exposure
assessments
were
conducted
using
the
Dietary
Exposure
Evaluation
Model
(
DEEM
 
)
software
Version
7.73,
which
incorporates
consumption
data
from
USDA's
Continuing
Surveys
of
Food
Intake
by
Individuals
(
CSFII),
1989­
1992.
The
1989­
92
data
are
based
on
the
reported
consumption
of
more
than
10,000
individuals
over
three
consecutive
days,
and
therefore
represent
more
than
30,000
unique
"
person
days"
of
data.
Foods
"
as
consumed"
(
e.
g.,
apple
pie)
are
linked
to
raw
agricultural
commodities
and
their
food
forms
(
e.
g.,
apples­
cooked/
canned
or
wheat­
flour)
by
recipe
translation
files
internal
to
the
DEEM
software.
Consumption
data
are
averaged
for
the
entire
US
population
and
within
population
subgroups
for
chronic
exposure
assessment,
but
are
retained
as
individual
consumption
events
for
acute
exposure
assessment.

For
chronic
exposure
and
risk
assessment,
an
estimate
of
the
residue
level
in
each
food
or
foodform
(
e.
g.,
orange
or
orange­
juice)
on
the
commodity
residue
list
is
multiplied
by
the
average
daily
consumption
estimate
for
that
food/
food
form.
The
resulting
residue
consumption
estimate
for
each
food/
food
form
is
summed
with
the
residue
consumption
estimates
for
all
other
food/
food
forms
on
the
commodity
residue
list
to
arrive
at
the
total
estimated
exposure.
Exposure
estimates
are
expressed
in
mg/
kg
body
weight/
day
and
as
a
percent
of
the
cPAD.
This
procedure
is
performed
for
each
population
subgroup.

For
acute
exposure
assessments,
individual
one­
day
food
consumption
data
are
used
on
an
individual­
by­
individual
basis.
The
reported
consumption
amounts
of
each
food
item
can
be
multiplied
by
a
residue
point
estimate
and
summed
to
obtain
a
total
daily
pesticide
exposure
for
a
deterministic
(
Tier
1
or
Tier
2)
exposure
assessment,
or
"
matched"
in
multiple
random
pairings
with
residue
values
and
then
summed
in
a
probabilistic
(
Tier
3/
4)
assessment.
The
resulting
distribution
of
exposures
is
expressed
as
a
percentage
of
the
aPAD
on
both
a
user
(
i.
e.,
those
who
reported
eating
relevant
commodities/
food
forms)
and
a
per­
capita
(
i.
e.,
those
who
reported
eating
the
relevant
commodities
as
well
as
those
who
did
not)
basis.
In
accordance
with
HED
policy,
per
capita
exposure
and
risk
are
reported
for
all
tiers
of
analysis.
However,
for
Tiers
1
and
2,
significant
differences
in
user
vs.
per
capita
exposure
and
risk
are
identified
and
noted
in
the
risk
assessment.
[
D278615
/
Company
Code]
Dietary
exposure
assessment
/
6
[
Dinocap/
036001]

6
Results/
Discussion
HED's
level
of
concern
is
100%
of
the
PAD.
That
is,
estimated
exposures
above
this
level
are
of
concern,
while
estimated
exposures
at
or
below
this
level
are
not
of
concern.
The
DEEM
analyses
estimate
the
dietary
exposure
of
the
U.
S.
population
and
26
population
subgroups.
The
results
reported
in
Table
2
is
for
females
13
­
50
years
old,
the
population
subgroup
of
concern.
Table
3
results
are
for
the
U.
S.
Population
(
total),
all
infants
(<
1
year
old),
children
1­
6,
children
7­
12,
females
13­
50,
males
13­
19,
males
20+,
and
seniors
55+.
The
results
for
the
other
population
subgroups
are
not
reported
in
Tables
2
and
3.
This
is
because
the
numbers
of
respondents
in
the
other
subgroups
were
not
sufficient,
and
thus
the
exposure
estimates
for
these
subgroups
contained
higher
levels
of
uncertainty.
However,
the
respondents
in
these
subgroups
were
also
part
of
larger
subgroups
which
are
listed
in
Tables
2
and
3.
For
example,
nursing
and
non­
nursing
infants
are
included
in
all
infants.
The
subgroups
which
are
broken
down
by
region,
season,
and
ethnicity
are
also
not
included.

Results
of
Acute
Dietary
Exposure
Analysis
Table
2.
Results
of
Acute
Dietary
Exposure
Analysis
at
the
99.9th
Percentile
of
Exposure
for
Females
13­
50
years
old
Data
Used
aPAD
(
mg/
kg/
day)
Exposure
(
mg/
kg/
day)
%
aPAD
Tolerance
of
0.1
ppm
0.004
0.000001
<
1
JMPR
MRLs
of
0.2
and
1
ppm
0.004
0.000019
<
1
Results
of
Chronic
Dietary
Exposure
Analysis
Table
3.
Results
of
Chronic
Dietary
Exposure
Analysis
Population
Subgroup
cPAD
(
mg/
kg/
day)
JMPR
MRLs
of
0.2
and
1
ppm
Tolerance
of
0.1
ppm
Exposure
(
mg/
kg/
day)
%
cPAD
Exposure
(
mg/
kg/
day)
%
cPAD
U.
S.
Population
(
total)
0.000375
0.000000
<
1
0.000000
<
1
All
Infants
(<
1
year)
0.000375
0.000001
<
1
0.000000
<
1
Children
1­
6
years
0.000375
0.000001
<
1
0.000000
<
1
Children
7­
12
years
0.000375
0.000000
<
1
0.000000
<
1
Females
13­
50
0.000375
0.000000
<
1
0.000000
<
1
Males
13­
19
0.000375
0.000000
<
1
0.000000
<
1
Males
20+
years
0.000375
0.000000
<
1
0.000000
<
1
Seniors
55+
0.000375
0.000000
<
1
0.000000
<
1
[
D278615
/
Company
Code]
Dietary
exposure
assessment
/
7
[
Dinocap/
036001]

7
Conclusions
The
Tier
2
acute
and
chronic
dietary
risk
assessment(
s)
were
conducted
for
all
supported
dinocap
food
uses.
Dietary
risk
estimates
are
provided
for
females
13
­
50
years
old
for
the
acute
assessment
and
for
the
general
U.
S.
population
and
various
population
subgroups
for
the
chronic
assessment.
This
assessment
shows
that
for
all
supported
registered
commodities,
the
acute
risk
estimates
are
below
the
Agency's
level
of
concern
(<
100%
aPAD)
at
the
99.9th
exposure
percentile
for
the
females
13
­
50
years
old
(<
1%
of
the
aPAD).
This
assessment
also
shows
that
for
all
commodities,
the
chronic
risk
estimates
are
below
the
Agency's
level
of
concern
(<
100%
cPAD)
for
the
general
U.
S.
population
and
all
population
subgroups
(<
1%
of
the
cPAD).

List
of
Attachments
Attachment
1
­
Acute
Dietary
Assessment
­
Using
JMPR
MRLs
Attachment
2
­
Acute
Dietary
Assessment
­
Using
Current
Tolerance
Attachment
3
­
Chronic
Dietary
Assessment
­
Using
JMPR
MRLs
Attachment
4
­
Chronic
Dietary
Assessment
­
Using
Current
Tolerance
Attachment
5
EMAIL
from
Frank
Hernandez
on
%
Crop
Treated
[
D278615
/
Company
Code]
Dietary
exposure
assessment
/
8
[
Dinocap/
036001]

8
Attachment
1
­
Acute
Dietary
Assessment
­
Using
JMPR
MRLs
Residue
File
U.
S.
Environmental
Protection
Agency
Ver.
7.74
DEEM
Acute
analysis
for
DINOCAP
Residue
file
name:
C:\$
MyFiles\
Dinocap\
acute
JMPR.
RS7
Analysis
Date
10­
18­
2001
Residue
file
dated:
10­
18­
2001/
16:
02:
46/
8
Reference
dose
(
aRfD)
=
0.004
mg/
kg
bw/
day
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Food
Crop
Def
Res
Adj.
Factors
Comment
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
13
O
Grapes
0.000500
1.000
1.000
14
O
Grapes­
raisins
0.000500
4.300
1.000
15
O
Grapes­
juice
0.000500
1.200
1.000
53
11
Apples­
dried
0.001000
8.000
1.000
54
11
Apples­
juice/
cider
0.001000
1.300
1.000
195
O
Grapes­
leaves
0.000500
1.000
1.000
315
O
Grapes­
wine
and
sherry
0.000500
1.000
1.000
377
11
Apples­
juice­
concentrate
0.001000
3.900
1.000
392
O
Grapes­
juice­
concentrate
0.000500
3.600
1.000
Results
U.
S.
Environmental
Protection
Agency
Ver.
7.74
DEEM
ACUTE
Analysis
for
DINOCAP
(
1989­
92
data)
Residue
file:
acute
JMPR.
RS7
Adjustment
factor
#
2
NOT
used
Analysis
Date:
10­
18­
2001/
16:
05:
45
Residue
file
dated:
10­
18­
2001/
16:
02:
46/
8
Daily
totals
for
food
and
foodform
consumption
used.
Run
Comment:
""
===============================================================================

Summary
calculations
(
per
capita):

95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
%
aRfD
Exposure
%
aRfD
Exposure
%
aRfD
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
Females
13+
(
preg/
not
nursing):
0.000005
0.13
0.000010
0.25
0.000025
0.62
Females
13+
(
nursing):
0.000007
0.17
0.000029
0.72
0.000029
0.72
Females
13­
19
(
not
preg
or
nursing):
0.000002
0.06
0.000008
0.19
0.000021
0.54
Females
20+
(
not
preg
or
nursing):
0.000002
0.06
0.000006
0.15
0.000015
0.37
[
D278615
/
Company
Code]
Dietary
exposure
assessment
/
9
[
Dinocap/
036001]

9
Females
13­
50
yrs:
0.000003
0.07
0.000007
0.17
0.000019
0.48
[
D278615
/
Company
Code]
Dietary
exposure
assessment
/
10
[
Dinocap/
036001]

10
Attachment
2
­
Acute
Dietary
Assessment
­
Using
Current
Tolerance
Residue
File
U.
S.
Environmental
Protection
Agency
Ver.
7.74
DEEM
Acute
analysis
for
DINOCAP
Residue
file
name:
C:\$
MyFiles\
Dinocap\
acute
tolerance.
RS7
Analysis
Date
10­
18­
2001
Residue
file
dated:
10­
18­
2001/
16:
02:
13/
8
Reference
dose
(
aRfD)
=
0.004
mg/
kg
bw/
day
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Food
Crop
Def
Res
Adj.
Factors
Comment
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
13
O
Grapes
0.000050
1.000
1.000
14
O
Grapes­
raisins
0.000050
4.300
1.000
15
O
Grapes­
juice
0.000050
1.200
1.000
53
11
Apples­
dried
0.000050
8.000
1.000
54
11
Apples­
juice/
cider
0.000050
1.300
1.000
195
O
Grapes­
leaves
0.000050
1.000
1.000
315
O
Grapes­
wine
and
sherry
0.000050
1.000
1.000
377
11
Apples­
juice­
concentrate
0.000050
3.900
1.000
392
O
Grapes­
juice­
concentrate
0.000050
3.600
1.000
Results
U.
S.
Environmental
Protection
Agency
Ver.
7.74
DEEM
ACUTE
Analysis
for
DINOCAP
(
1989­
92
data)
Residue
file:
acute
tolerance.
RS7
Adjustment
factor
#
2
NOT
used
Analysis
Date:
10­
18­
2001/
16:
07:
04
Residue
file
dated:
10­
18­
2001/
16:
02:
13/
8
Daily
totals
for
food
and
foodform
consumption
used.
Run
Comment:
""
===============================================================================

Summary
calculations
(
per
capita):

95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
%
aRfD
Exposure
%
aRfD
Exposure
%
aRfD
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
Females
13+
(
preg/
not
nursing):
0.000000
0.01
0.000000
0.01
0.000001
0.04
Females
13+
(
nursing):
0.000001
0.01
0.000002
0.04
0.000002
0.04
Females
13­
19
(
not
preg
or
nursing):
0.000000
0.00
0.000000
0.01
0.000001
0.03
[
D278615
/
Company
Code]
Dietary
exposure
assessment
/
11
[
Dinocap/
036001]

11
Females
20+
(
not
preg
or
nursing):
0.000000
0.00
0.000000
0.01
0.000001
0.02
Females
13­
50
yrs:
0.000000
0.01
0.000000
0.01
0.000001
0.03
[
D278615
/
Company
Code]
Dietary
exposure
assessment
/
12
[
Dinocap/
036001]

12
Attachment
3
­
Chronic
Dietary
Assessment
­
Using
JMPR
MRLs
Residue
File
U.
S.
Environmental
Protection
Agency
Ver.
7.73
DEEM
Chronic
analysis
for
DINOCAP
1989­
92
data
Residue
file:
C:\$
MyFiles\
Dinocap\
chronic
JMPR.
RS7
Adjust.
#
2
used
Analysis
Date
10­
18­
2001
Residue
file
dated:
10­
18­
2001/
15:
59:
05/
8
Reference
dose
(
RfD)
=
0.000375
mg/
kg
bw/
day
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Food
Crop
RESIDUE
Adj.
Factors
Commen
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­
13
O
Grapes
1.000000
1.000
0.001
14
O
Grapes­
raisins
1.000000
4.300
0.001
15
O
Grapes­
juice
1.000000
1.200
0.001
53
11
Apples­
dried
0.200000
8.000
0.001
54
11
Apples­
juice/
cider
0.200000
1.300
0.001
195
O
Grapes­
leaves
1.000000
1.000
0.001
315
O
Grapes­
wine
and
sherry
1.000000
1.000
0.001
377
11
Apples­
juice­
concentrate
0.200000
3.900
0.001
392
O
Grapes­
juice­
concentrate
1.000000
3.600
0.001
Results
U.
S.
Environmental
Protection
Agency
Ver.
7.73
DEEM
Chronic
analysis
for
DINOCAP
(
1989­
92
data)
Residue
file
name:
C:\$
MyFiles\
Dinocap\
chronic
JMPR.
RS7
Adjustment
factor
#
2
used.
Analysis
Date
10­
18­
2001/
16:
03:
32
Residue
file
dated:
10­
18­
2001/
15:
59:
05/
8
Reference
dose
(
RfD,
Chronic)
=
.000375
mg/
kg
bw/
day
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.000000
0.1%

U.
S.
Population
(
spring
season)
0.000000
0.1%
U.
S.
Population
(
summer
season)
0.000000
0.1%
U.
S.
Population
(
autumn
season)
0.000000
0.1%
U.
S.
Population
(
winter
season)
0.000000
0.1%

Northeast
region
0.000000
0.1%
Midwest
region
0.000000
0.1%
Southern
region
0.000000
0.1%
Western
region
0.000000
0.1%

Hispanics
0.000000
0.1%
[
D278615
/
Company
Code]
Dietary
exposure
assessment
/
13
[
Dinocap/
036001]

13
Non­
hispanic
whites
0.000000
0.1%
Non­
hispanic
blacks
0.000000
0.1%
Non­
hisp/
non­
white/
non­
black
0.000000
0.1%

All
infants
(<
1
year)
0.000001
0.3%
Nursing
infants
0.000001
0.2%
Non­
nursing
infants
0.000001
0.3%
Children
1­
6
yrs
0.000001
0.3%
Children
7­
12
yrs
0.000000
0.1%

Females
13­
19
(
not
preg
or
nursing)
0.000000
0.0%
Females
20+
(
not
preg
or
nursing)
0.000000
0.1%
Females
13­
50
yrs
0.000000
0.1%
Females
13+
(
preg/
not
nursing)
0.000000
0.1%
Females
13+
(
nursing)
0.000001
0.1%

Males
13­
19
yrs
0.000000
0.0%
Males
20+
yrs
0.000000
0.0%
Seniors
55+
0.000000
0.1%
Pacific
Region
0.000000
0.1%

Attachment
4
­
Chronic
Dietary
Assessment
­
Using
Current
Tolerance
Residue
File
U.
S.
Environmental
Protection
Agency
Ver.
7.73
DEEM
Chronic
analysis
for
DINOCAP
1989­
92
data
Residue
file:
C:\$
MyFiles\
Dinocap\
chronic
tolerance.
RS7
Adjust.
#
2
used
Analysis
Date
10­
18­
2001
Residue
file
dated:
10­
18­
2001/
15:
58:
28/
8
Reference
dose
(
RfD)
=
0.000375
mg/
kg
bw/
day
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Food
Crop
RESIDUE
Adj.
Factors
Commen
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­
13
O
Grapes
0.100000
1.000
0.001
14
O
Grapes­
raisins
0.100000
4.300
0.001
15
O
Grapes­
juice
0.100000
1.200
0.001
53
11
Apples­
dried
0.100000
8.000
0.001
54
11
Apples­
juice/
cider
0.100000
1.300
0.001
195
O
Grapes­
leaves
0.100000
1.000
0.001
315
O
Grapes­
wine
and
sherry
0.100000
1.000
0.001
377
11
Apples­
juice­
concentrate
0.100000
3.900
0.001
392
O
Grapes­
juice­
concentrate
0.100000
3.600
0.001
Results
U.
S.
Environmental
Protection
Agency
Ver.
7.73
DEEM
Chronic
analysis
for
DINOCAP
(
1989­
92
data)
Residue
file
name:
C:\$
MyFiles\
Dinocap\
chronic
tolerance.
RS7
Adjustment
factor
#
2
used.
Analysis
Date
10­
18­
2001/
16:
04:
16
Residue
file
dated:
10­
18­
2001/
15:
58:
28/
8
Reference
dose
(
RfD,
Chronic)
=
.000375
mg/
kg
bw/
day
[
D278615
/
Company
Code]
Dietary
exposure
assessment
/
14
[
Dinocap/
036001]

14
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.000000
0.0%

U.
S.
Population
(
spring
season)
0.000000
0.0%
U.
S.
Population
(
summer
season)
0.000000
0.0%
U.
S.
Population
(
autumn
season)
0.000000
0.0%
U.
S.
Population
(
winter
season)
0.000000
0.0%

Northeast
region
0.000000
0.0%
Midwest
region
0.000000
0.0%
Southern
region
0.000000
0.0%
Western
region
0.000000
0.0%

Hispanics
0.000000
0.0%
Non­
hispanic
whites
0.000000
0.0%
Non­
hispanic
blacks
0.000000
0.0%
Non­
hisp/
non­
white/
non­
black
0.000000
0.0%

All
infants
(<
1
year)
0.000000
0.1%
Nursing
infants
0.000000
0.1%
Non­
nursing
infants
0.000000
0.1%
Children
1­
6
yrs
0.000000
0.1%
Children
7­
12
yrs
0.000000
0.0%

Females
13­
19
(
not
preg
or
nursing)
0.000000
0.0%
Females
20+
(
not
preg
or
nursing)
0.000000
0.0%
Females
13­
50
yrs
0.000000
0.0%
Females
13+
(
preg/
not
nursing)
0.000000
0.0%
Females
13+
(
nursing)
0.000000
0.0%

Males
13­
19
yrs
0.000000
0.0%
Males
20+
yrs
0.000000
0.0%
Seniors
55+
0.000000
0.0%

Pacific
Region
0.000000
0.0%

Attachment
5
EMAIL
from
Frank
Hernandez
on
%
Crop
Treated
Yes,
less
than
5%
of
apples
or
grapes
are
imported,
and
less
than
1%,
of
those
5%
imported,
are
treated.

­­­­­
Forwarded
by
Frank
Hernandez/
DC/
USEPA/
US
on
10/
17/
01
08:
07
AM
­­­­­
Felicia
Fort
10/
16/
01
08:
26
AM
[
D278615
/
Company
Code]
Dietary
exposure
assessment
/
15
[
Dinocap/
036001]

15
To:
Frank
Hernandez/
DC/
USEPA/
US@
EPA
cc:
Subject:
Re:
QUA
for
Dinocap
Thanks
for
the
information.
Can
I
safely
say
that
less
than
1%
of
apples
and
grapes
are
imported?
I
need
a
figure
so
that
I
can
use
it
in
the
dietary
assessment.
Thanks
again.

Frank
Hernandez
10/
11/
01
09:
02
AM
To:
Felicia
Fort/
DC/
USEPA/
US@
EPA
cc:
Subject:
QUA
for
Dinocap
Hi
Felecia!
Very
few
countries
use
dinocap
on
their
apples
or
grapes.
Dinocap
is
used
on
less
than
1%
of
the
apples
or
grapes
in
the
countries
from
which
we
import
apples
or
grapes.
Imports
also
make
up
a
relatively
small
part
of
the
annual
U.
S.
consumption
of
apples
or
grapes.
Frank
­­­­­
Forwarded
by
Frank
Hernandez/
DC/
USEPA/
US
on
10/
05/
01
09:
16
AM
­­­­­
Felicia
Fort
10/
01/
01
01:
19
PM
To:
Frank
Hernandez/
DC/
USEPA/
US@
EPA
cc:
Subject:
QUA
for
Dinocap