Document ID: EPA-HQ-OPP-2004-0167-0009
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2004-05-20T04:00Z

Appendix
E:
Residential
Handler
Exposure
Data
and
Risk
Calculations
for
2,4­
D
2
Table
E1:
Unit
Exposure
Data
for
2,4­
D
Residential
Exposure
Assessment
Scenario
Data
Source
Unit
Exposure
Values
(
Per
lb
AE
Handled)
Data
Confidence
Residential
Handler
Scenarios
1
­
Hand
Application
of
Granules
PHED
Dermal
=
114
mg
Inhalation
=
467
ug
N
=
16
dermal
,
hand
and
inhalation
replicates
with
grade
ABC
data.
Hand
data
was
for
gloved
hand
and
required
10X
adjustment
for
use
without
gloves.

2
­
Belly
Grinder
Application
PHED
Dermal
=
110
mg
Inhalation
=
62
ug
N
=
20
to
45
dermal
replicates,
ABC
grades.
Hand
replicates
=
23,
ABC
grades.
Medium
Confidence.

N
=
40
Inhalation
replicates,
AB
grades,
High
Confidence.

3.
Load/
Apply
Granules
with
a
Broadcast
Spreader
ORETF
1
Dermal
=
0.68
mg
Inhalation
=
0.91
ug
Grade
AB
Data.
N
=
30
replicates.
High
Confidence
despite
large
variability
in
results.

4.
Mix/
Load/
Apply
with
a
Hose­
end
Sprayer
(
Mix
your
own)
ORETF1
Dermal
=
11
mg
Inhalation
=
16
ug
Grade
A
Data.
N
=
30
replicates.
High
Confidence.

5.
Mix/
Load/
Apply
with
a
Hose­
end
Sprayer
(
Ready
to
Use)
ORETF1
Dermal
=
2.6
mg
Inhalation
=
11
ug
Grade
A
Data.
N
=
30
replicates.
High
Confidence.

6.
Mix/
Load/
Apply
with
Hand
Held
Pump
Sprayer
MRID2
444598­
01
Dermal
=
38
mg
Inhalation
=
9
ug
A
total
of
40
replicates
per
application
method
were
monitored
in
this
study.
Half
of
the
people
wore
gloves
and
the
other
half
did
not.
The
clothing
scenario
represents
short­
sleeved
shirt,
short
pants,
and
no
gloves.
The
data
are
considered
high
quality
by
the
Agency.

7.
Mix/
Load/
Apply
with
Ready
to
Use
Sprayer
MRID
444598­

01
Dermal
=
54
mg
Inhalation
=
67
ug
Notes
for
Table
1
1.
This
study
involved
the
application
of
granular
and
liquid
formulations
of
Dacthal
to
residential
lawns.
It
was
reviewed
by
Health
Canada
and
Gary
Bangs
in
Document
#
D261948.

2.
This
study
involved
the
application
of
liquid
carbaryl
to
home
garden
vegetables.
It
was
reviewed
by
Jeff
Dawson
in
Document
#
D287251.
3
Table
E2­
2,4­
D
Short
Term
MOEs
for
Homeowner
Applications
to
Lawns
Exposure
Scenario
Application
Rates
(
lb
ae/
Acre)
Treated
Areas
(
Acre/
day)
Amount
of
A.
E.

Handled
per
Day
(
lbs)
Daily
Exposure
(
mg/
day)
a
Daily
Dose
(
mg/
kg/
day)
b
Combined
Daily
Dose
(
mg/
kg/
day)
c
2,4­
D
MOEd
Dermal
Inhalation
Dermal
Inhalation
1
­
Apply
Granules
by
Hand
or
Shaker
Can
2.0
0.023
0.046
5.24
2.1e­
02
5.1e­
03
3.6e­
04
5.4e­
03
4606
2
­
Load/
Apply
Granules
with
a
Belly
Grinder
2.0
0.023
0.046
5.06
2.9e­
03
4.9e­
03
4.8e­
05
4.9e­
03
5062
3
­
Load/
Apply
Granules
with
a
Broadcast
Spreader
2.0
0.500
1.000
0.68
9.1e­
05
6.6e­
04
1.5e­
06
6.6e­
04
37945
4
­
Mix/
Load/
Apply
Liquids
with
a
Hose­
end
Sprayer
(
Mix
your
own)
2.0
0.500
1.000
11.0
1.6e­
02
1.1e­
02
2.7e­
04
1.1e­
02
2294
5
­
Mix/
Load/
Apply
Liquids
with
a
Hose­
end
Sprayer
(
Ready
to
Use)
2.0
0.500
1.000
2.6
1.1e­
02
2.5e­
03
1.8e­
04
2.7e­
03
9271
6
­
Mix/
Load/
Apply
Liquids
with
Hand
Held
Pump
Sprayer
2.0
0.023
0.046
1.7
4.1e­
04
1.7e­
03
6.9e­
06
1.7e­
03
14735
7
­
Mix/
Load/
Apply
Liquids
with
Ready
to
Use
Sprayer
2.0
0.023
0.046
2.5
3.1e­
03
2.4e­
03
5.1e­
05
2.5e­
03
10193
a
Daily
Exposure
(
mg/
day)
=
Application
Rate
(
lb
ae/
Acre)
*
Treated
Area
(
Acre/
day)
*
Unit
Exposure
Value
(
mg
or

g
exposure/
lb
ae
handled)
*[
1mg/
1000

g
(
conversion
factor
if
necessary)].

b
Daily
Dose
(
mg/
kg/
day)
=
Daily
Exposure
(
mg/
day)
*
Absorption
Factor
(
0.058
for
dermal;
1.0
for
inhalation)
÷
Body
Weight
(
60kg).

c
Combined
Daily
Dose
(
mg/
kg/
day)
=
Dermal
Daily
Dose
(
mg/
kg/
day)
+
Inhalation
Daily
Dose
(
mg/
kg/
day).

d
MOE
=
NOAEL
/
Daily
Dose
(
mg/
kg/
day)
where
NOEAL
=
25mg/
kg/
day