Document ID: EPA-HQ-OPPT-2003-0028-0006
Agency: epa
Document Type: Notice
Title: Forty-Seventh Report of the TSCA Interagency Testing Committee to the Administrator, Receipt of Report and Request for Comments
Posted Date: 2003-07-10T04:00Z

Tuesday,

April
3,
2001
Part
IV
Environmental
Protection
Agency
Forty­
Seventh
Report
of
the
TSCA
Interagency
Testing
Committee
to
the
Administrator,
Receipt
of
Report
and
Request
for
Comments;
Notice
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RECEIVED
OPPT
NCIC
2003
JUL
10
7:
44AM
OPPT­
2003­
0028­
0006
17768
Federal
Register
/
Vol.
66,
No.
64
/
Tuesday,
April
3,
2001
/
Notices
ENVIRONMENTAL
PROTECTION
AGENCY
[
OPPTS
 
41055;
FRL
 
6763
 
6]

Forty­
Seventh
Report
of
the
TSCA
Interagency
Testing
Committee
to
the
Administrator;
Receipt
of
Report
and
Request
for
Comments
AGENCY:
Environmental
Protection
Agency
(
EPA).
ACTION:
Notice.

SUMMARY:
The
Toxic
Substances
Control
Act
(
TSCA)
Interagency
Testing
Committee
(
ITC)
transmitted
its
47th
ITC
Report
to
the
Administrator
of
the
EPA
on
November
30,
2000.
In
the
47th
ITC
Report,
which
is
included
in
this
notice,
the
ITC
adds
37
indium
chemicals
and
4
other
chemicals
discussed
in
the
46th
ITC
Report
as
recommended
chemicals
to
its
Priority
Testing
List.
The
ITC
requests
TSCA
section
8(
a)
Preliminary
Assessment
Information
Reporting
(
PAIR)
rules
for
the
appropriate
CAS
numbered
chemicals
and
TSCA
section
8(
d)
Health
and
Safety
Data
reporting
rules
be
promulgated
by
the
EPA
for
these
chemicals
and
the
8
nonylphenol
polyethoxylate
degradation
products
placed
on
the
Priority
Testing
List
in
the
46th
ITC
Report.
The
ITC
is
also
placing
three
chloroalkenes
as
recommended
chemicals
on
the
ITC's
Priority
Testing
List
in
order
to
solicit
information
on
use,
exposure,
ecological
effects,
environmental
fate,
and
health
effects
under
the
ITC's
Voluntary
Information
Submission
Policy
(
VISP).
This
action
is
part
of
the
ITC's
ongoing
efforts
to
screen
chemicals
with
potential
to
persist
and
bioconcentrate.
DATES:
Comments,
identified
by
docket
control
number
OPPTS
 
41055,
must
be
received
on
or
before
May
3,
2001.
ADDRESSES:
Comments
may
be
submitted
by
mail,
electronically,
or
in
person.
Please
follow
the
detailed
instructions
for
each
method
as
provided
in
Unit
I.
of
the
SUPPLEMENTARY
INFORMATION.
To
ensure
proper
receipt
by
EPA,
it
is
imperative
that
you
identify
docket
control
number
OPPTS
 
41055
in
the
subject
line
on
the
first
page
of
your
response.
FOR
FURTHER
INFORMATION
CONTACT:
For
general
information
contact:
Barbara
Cunningham,
Acting
Director,
Environmental
Assistance
Division
(
7408),
Office
of
Pollution
Prevention
and
Toxics,
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460;
telephone
number:
(
202)
554
 
1404;
e­
mail
address:
TSCA­
Hotline@
epa.
gov.
For
technical
information
contact:
John
D.
Walker,
ITC
Executive
Director
(
7401),
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460;
telephone
number:
(
202)
260
 
1825;
fax:
(
202)
260
 
7895;
e­
mail
address:
walker.
johnd@
epa.
gov.

SUPPLEMENTARY
INFORMATION:

I.
General
Information
A.
Does
this
Action
Apply
to
Me?
This
notice
is
directed
to
the
public
in
general.
It
may,
however,
be
of
particular
interest
to
you
if
you
manufacture
(
defined
by
statute
to
include
import)
and/
or
process
TSCAcovered
chemicals
and
you
may
be
identified
by
the
North
American
Industrial
Classification
System
(
NAICS)
codes
325
and
32411.
Because
this
notice
is
directed
to
the
general
public
and
other
entities
may
also
be
interested,
the
Agency
has
not
attempted
to
describe
all
the
specific
entities
that
may
be
interested
in
this
action.
If
you
have
any
questions
regarding
the
applicability
of
this
action
to
a
particular
entity,
consult
the
technical
person
listed
under
FOR
FURTHER
INFORMATION
CONTACT.

B.
How
Can
I
Get
Additional
Information,
Including
Copies
of
this
Document
or
Other
Related
Documents?
1.
Electronically.
You
may
obtain
electronic
copies
of
this
document,
and
certain
other
related
documents
that
might
be
available
electronically,
from
the
EPA
Internet
Home
Page
at
http://
www.
epa.
gov/.
To
access
this
document,
on
the
Home
Page
select
``
Laws
and
Regulations,''
``
Regulations
and
Proposed
Rules,''
and
then
look
up
the
entry
for
this
document
under
the
``
Federal
Register
 
Environmental
Documents.''
You
can
also
go
directly
to
the
Federal
Register
listings
at
http://
www.
epa.
gov/
fedrgstr/.
You
may
also
access
additional
information
about
the
ITC
and
the
TSCA
testing
program
through
the
web
site
for
the
Office
of
Pollution
Prevention
and
Toxics
(
OPPT)
at
http://
www.
epa.
gov/
opptintr/,
or
go
directly
to
the
ITC
Home
Page
at
http://
www.
epa.
gov/
opptintr/
itc/.
2.
In
person.
The
Agency
has
established
an
official
record
for
this
action
under
docket
control
number
OPPTS
 
41055.
The
official
record
consists
of
the
documents
specifically
referenced
in
this
action,
any
public
comments
received
during
an
applicable
comment
period,
and
other
information
related
to
this
action,
including
any
information
claimed
as
Confidential
Business
Information
(
CBI).
This
official
record
includes
the
documents
that
are
physically
located
in
the
docket,
as
well
as
the
documents
that
are
referenced
in
those
documents.
The
public
version
of
the
official
record
does
not
include
any
information
claimed
as
CBI.
The
public
version
of
the
official
record,
which
includes
printed,
paper
versions
of
any
electronic
comments
submitted
during
an
applicable
comment
period,
is
available
for
inspection
in
the
TSCA
Nonconfidential
Information
Center,
North
East
Mall
Rm.
B
 
607,
Waterside
Mall,
401
M
St.,
SW.,
Washington,
DC.
The
Center
is
open
from
noon
to
4
p.
m.,
Monday
through
Friday,
excluding
legal
holidays.
The
telephone
number
for
the
Center
is
(
202)
260
 
7099.

C.
How
and
to
Whom
Do
I
Submit
Comments?
You
may
submit
comments
through
the
mail,
in
person,
or
electronically.
To
ensure
proper
receipt
by
EPA,
it
is
imperative
that
you
identify
docket
control
number
OPPTS
 
41055
in
the
subject
line
on
the
first
page
of
your
response.
1.
By
mail.
Submit
your
comments
to:
Document
Control
Office
(
7407),
Office
of
Pollution
Prevention
and
Toxics
(
OPPT),
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460.
2.
In
person
or
by
courier.
Deliver
your
comments
to:
OPPT
Document
Control
Office
(
DCO)
in
East
Tower
Rm.
G
 
099,
Waterside
Mall,
401
M
St.,
SW.,
Washington,
DC.
The
DCO
is
open
from
8
a.
m.
to
4
p.
m.,
Monday
through
Friday,
excluding
legal
holidays.
The
telephone
number
for
the
DCO
is
(
202)
260
 
7093.
3.
Electronically.
You
may
submit
your
comments
electronically
by
e­
mail
to:
oppt.
ncic@
epa.
gov,
or
mail
your
computer
disk
to
the
address
identified
above.
Do
not
submit
any
information
electronically
that
you
consider
to
be
CBI.
Electronic
comments
must
be
submitted
as
an
ASCII
file
avoiding
the
use
of
special
characters
and
any
form
of
encryption.
Comments
and
data
will
also
be
accepted
on
standard
disks
in
WordPerfect
6.1/
8.0
or
ASCII
file
format.
All
comments
in
electronic
form
must
be
identified
by
docket
control
number
OPPTS
 
41055.
Electronic
comments
may
also
be
filed
online
at
many
Federal
Depository
Libraries.

D.
How
Should
I
Handle
CBI
Information
That
I
Want
to
Submit
to
the
Agency?
Do
not
submit
any
information
electronically
that
you
consider
to
be
CBI.
You
may
claim
information
that
you
submit
to
EPA
in
response
to
this
document
as
CBI
by
marking
any
part
or
all
of
that
information
as
CBI.
Information
so
marked
will
not
be
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Federal
Register
/
Vol.
66,
No.
64
/
Tuesday,
April
3,
2001
/
Notices
disclosed
except
in
accordance
with
procedures
set
forth
in
40
CFR
part
2.
In
addition
to
one
complete
version
of
the
comment
that
includes
any
information
claimed
as
CBI,
a
copy
of
the
comment
that
does
not
contain
the
information
claimed
as
CBI
must
be
submitted
for
inclusion
in
the
public
version
of
the
official
record.
Information
not
marked
confidential
will
be
included
in
the
public
version
of
the
official
record
without
prior
notice.
If
you
have
any
questions
about
CBI
or
the
procedures
for
claiming
CBI,
please
consult
the
technical
person
listed
under
FOR
FURTHER
INFORMATION
CONTACT.

E.
What
Should
I
Consider
as
I
Prepare
My
Comments
for
EPA?

We
invite
you
to
provide
your
views
and
comments
on
the
47th
ITC
Report.
You
may
find
the
following
suggestions
helpful
for
preparing
your
comments:
1.
Explain
your
views
as
clearly
as
possible.
2.
Describe
any
assumptions
that
you
used.
3.
Provide
copies
of
any
technical
information
and/
or
data
you
used
that
support
your
views.
4.
Provide
specific
examples
to
illustrate
your
concerns.
5.
Make
sure
to
submit
your
comments
by
the
deadline
in
this
notice.
6.
To
ensure
proper
receipt
by
EPA,
be
sure
to
identify
the
docket
control
number
assigned
to
this
action
in
the
subject
line
on
the
first
page
of
your
response.
You
may
also
provide
the
name,
date,
and
Federal
Register
citation.

II.
Background
The
Toxic
Substances
Control
Act
(
TSCA)
(
15
U.
S.
C.
2601
et
seq.)
authorizes
the
Administrator
of
the
EPA
to
promulgate
regulations
under
TSCA
section
4(
a)
requiring
testing
of
chemicals
and
chemical
groups
in
order
to
develop
data
relevant
to
determining
the
risks
that
such
chemicals
and
chemical
groups
may
present
to
health
or
the
environment.
Section
4(
e)
of
TSCA
established
the
ITC
to
recommend
chemicals
and
chemical
groups
to
the
Administrator
of
the
EPA
for
priority
testing
consideration.
Section
4(
e)
of
TSCA
directs
the
ITC
to
revise
the
TSCA
section
4(
e)
Priority
Testing
List
at
least
every
6
months.
1.
The
47th
ITC
Report.
The
47th
ITC
Report
was
received
by
the
EPA
Administrator
on
November
30,
2000,
and
is
included
in
this
notice.
In
the
47th
ITC
Report,
the
ITC:
i.
Adds
37
indium
chemicals
(
see
Table
2
of
the
47th
ITC
Report)
and
4
other
chemicals
discussed
in
the
46th
ITC
Report
as
recommended
chemicals
to
its
Priority
Testing
List.
The
ITC
requests
TSCA
section
8(
a)
PAIR
rules
for
the
appropriate
CAS
numbered
chemicals
and
TSCA
section
8(
d)
Health
and
Safety
Data
reporting
rules
be
promulgated
by
the
EPA
for
these
chemicals
and
the
8
nonylphenol
polyethoxylate
degradation
products
placed
on
the
Priority
Testing
List
in
the
46th
ITC
Report.
The
chemicals,
for
which
needed
information
was
not
provided
in
response
to
the
VISP
published
in
the
46th
ITC
Report,
are:
Pentachlorothiophenol
(
CAS
No.
133
 
49
 
3,
from
the
class
``
polychlorobenzenethiols'');
tetrachloropyrocatechol
(
CAS
No.
1198
 
55
 
6,
from
the
class
``
polychlorophenols'');
p­
toluidine,
5­
chloro­.
alpha.,.
alpha.,.
alpha.­
trifluoro­
2­
nitro­
N­
phenyl­
(
CAS
No.
1806
 
24
 
2,
from
the
class
``
chlorotrifluoromethylphenoxy
benzenes'')
benzoic
acid,
3­[
2­
chloro­
4­
(
trifluoromethyl)
phenoxy]­
2­
ethoxy­
1­
methyl­
2­
oxo­
(
CAS
No.
88185
 
22
 
2,
from
the
class
``
chlorotrifluoromethylphenoxy
benzenes'').
In
addition,
no
information
was
provided
on
the
following
eight
nonylphenol
polyethoxylate
degradation
products:
4­
nonylphenol
ethoxylate
(
CAS
No.
104
 
35
 
8);
4­
nonylphenol
diethoxylate
(
CAS
No.
20427
 
84
 
3);
4­
nonylphenoxy
acetic
acid
(
CAS
No.
3115
 
49
 
9);
4­
nonylphenoxy
ethoxy
acetic
acid
(
CAS
No.
106807
 
78
 
7);
4­
nonylphenoxy
diethoxy
acetic
acid
(
CAS
No.
108241
 
00
 
5);
4­
nonylphenoxy
triethoxy
acetic
acid;
4­
nonylphenol
triethoxylate;
and
4­
nonylphenol
tetraethoxylate.
ii.
Places
three
chloroalkenes
[
1,3­
butadiene,
1,1,2,3,4­
pentachloro­
4­(
1­
methylethoxy)­
(
CAS
No.
68334
 
67
 
8);
3­
butenoic
acid,
2,2,3,4,4­
pentachloro­,
butyl
ester
(
CAS
No.
75147
 
20
 
5);
and
2,2,3,4,4­
pentachloro­
3­
butenoic
acid
(
CAS
No.
85743
 
61
 
9)]
as
recommended
chemicals
on
the
Priority
Testing
List
in
order
to
solicit
information
on
use,
exposure,
ecological
effects,
environmental
fate,
and
health
effects
under
the
ITC's
VISP.
This
action
is
part
of
the
ITC's
ongoing
efforts
to
screen
chemicals
with
potential
to
persist
and
bioconcentrate.
2.
Status
of
the
Priority
Testing
List.
The
current
TSCA
section
4(
e)
Priority
Testing
List
as
of
November
2000
can
be
found
in
Table
1
of
the
47th
ITC
Report
which
is
included
in
this
notice.

List
of
Subjects
Environmental
protection,
Chemicals,
Hazardous
substances.
Dated:
March
23,
2001.
Charles
M.
Auer,
Director,
Chemical
Control
Division,
Office
of
Pollution
Prevention
and
Toxics.
Seventh
Report
of
the
TSCA
Interagency
Testing
Committee
to
the
Administrator,
U.
S.
Environmental
Protection
Agency
Table
of
Contents
Summary
The
TSCA
Section
4(
e)
Priority
Testing
List
(
November
2000)
I.
Background
II.
TSCA
Section
8
Reporting
A.
TSCA
section
8
rules
B.
ITC's
use
of
TSCA
section
8
and
``
other
information''
C.
Promoting
more
efficient
use
of
information
submission
resources
D.
Requests
related
to
promulgation
of
TSCA
section
8(
a)
PAIR
and
section
8(
d)
HaSD
reporting
rules
III.
ITC's
Activities
During
this
Reporting
Period
(
May
to
October
2000):
Information
Solicitations
IV.
Revisions
to
the
TSCA
Section
4(
e)
Priority
Testing
List:
Chemicals
added
to
the
Priority
Testing
List:
A.
Indium
Chemicals
B.
Chloroalkenes
C.
Polychlorophenols
and
Polychlorobenzenethiols
D.
Chlorotrifluoromethylphenoxy
Benzenes
V.
References
VI.
The
TSCA
Interagency
Testing
Committee
Summary
This
is
the
47th
Report
of
the
Toxic
Substances
Control
Act
(
TSCA)
Interagency
Testing
Committee
(
ITC)
to
the
Administrator
of
the
U.
S.
Environmental
Protection
Agency
(
EPA).
In
this
Report,
the
ITC
is
adding
37
indium
chemicals
and
four
other
chemicals
discussed
in
the
46th
Report
which
was
published
in
the
Federal
Register
of
December
1,
2000
(
65
FR
75552)
(
FRL
 
6594
 
7)
to
its
Priority
Testing
List
so
that
TSCA
section
8(
a)
Preliminary
Assessment
Information
Reporting
(
PAIR)
and
TSCA
section
8(
d)
Health
and
Safety
Data
(
HaSD)
reporting
rules
will
be
promulgated
by
the
EPA.
There
is
reason
to
believe
the
indium
chemicals
have
potential
to
cause
cancer
in
humans.
The
four
chemicals
discussed
in
the
46th
Report
that
are
being
added
to
the
Priority
Testing
List
are,
pentachlorothiophenol
and
tetrachloropyrocatechol
(
from
the
class
polychlorophenols
and
polychlorobenzenethiols),
and
ptoluidine
5­
chloro­
.
alpha.,.
alpha.,.
alpha.­
trifluoro­
2­
nitro­
N­
phenyl
and
benzoic
acid,
3­[
2­
chloro­
4­(
trifluoromethyl)
phenoxy]­,
2­
ethoxy­
1­
methyl­
2­
oxo
(
from
the
class
chlorotrifluoromethylphenoxy
benzenes).
The
four
chemicals
are
being
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/
Notices
added
to
the
Priority
Testing
List,
because
information
solicited
in
the
ITC's
46th
Report
under
the
Voluntary
Information
Submissions
Policy
(
VISP)
was
not
provided
to
the
ITC.
The
ITC
is
also
asking
EPA
to
promulgate
TSCA
section
8(
a)
PAIR
and
TSCA
section
8(
d)
HaSD
reporting
rules
for
the
8
nonylphenol
polyethoxylate
degradation
products
that
were
added
to
the
Priority
Testing
List
in
the
ITC's
46th
Report,
because
information
requested
for
these
chemicals
was
not
voluntarily
provided
to
the
ITC.
The
ITC
is
placing
three
chloroalkenes
on
the
Priority
Testing
List
in
order
to
solicit
information
on
use,
exposure,
ecological
effects,
environmental
fate,
and
health
effects
under
VISP.
This
action
is
part
of
the
ongoing
effort
to
screen
chemicals
with
potential
to
persist
and
bioconcentrate.
The
revised
TSCA
section
4(
e)
Priority
Testing
List
follows
as
Table
1
of
this
unit.

TABLE
1.
 
THE
TSCA
SECTION
4(
E)
PRIORITY
TESTING
LIST
(
NOVEMBER
2000)

Report
Date
Chemical/
Group
Action
28
............................
May
1991
..............................................
Chemicals
with
low
confidence
reference
dose
(
RfD)
........
Acetone
Thiophenol
Designated
30
............................
May
1992
..............................................
5
Siloxanes
..........................................................................
Recommended
31
............................
January
1993
........................................
13
Chemicals
with
insufficient
dermal
absorption
rate
data
Designated
32
............................
May
1993
..............................................
16
Chemicals
with
insufficient
dermal
absorption
rate
data
Designated
35
............................
November
1994
....................................
4
Chemicals
with
insufficient
dermal
absorption
rate
data
..
Designated
37
............................
November
1995
....................................
10
Alkylphenols
and
2
alkylphenol
polyethoxylates
............
Recommended
39
............................
November
1996
....................................
8
Nonylphenol
ethoxylates
...................................................
Recommended
41
............................
November
1997
....................................
18
Alkylphenols,
5
polyalkylphenols
and
6
alkylphenol
polyethoxylates.
Recommended
42
............................
May
1998
..............................................
3­
Amino­
5­
mercapto­
1,2,4­
triazole
......................................
Recommended
42
............................
May
1998
..............................................
Glycoluril
..............................................................................
Recommended
42
............................
May
1998
..............................................
Methylal
................................................................................
Recommended
42
............................
May
1998
..............................................
Ethyl
Silicate
........................................................................
Recommended
46
............................
May
2000
..............................................
8
Nonylphenol
polyethoxylate
degradation
products
...........
Recommended
47
............................
November
2000
....................................
37
Indium
chemicals
............................................................
Recommended
47
............................
November
2000
....................................
Pentachlorothiophenol
.........................................................
Recommended
47
............................
November
2000
....................................
Tetrachloropyrocatechol
.......................................................
Recommended
47
............................
November
2000
....................................
p­
Toluidine,
5­
chloro­.
alpha.,.
alpha.,.
alpha.­
trifluoro­
2­
nitro­
N­
phenyl.
Recommended
47
............................
November
2000
....................................
Benzoic
acid,
3­[
2­
chloro­
4­(
trifluoromethyl)
phenoxy]­,
2­
ethoxy­
1­
methyl­
2­
oxo.
Recommended
47
............................
November
2000
....................................
3
Chloroalkenes
...................................................................
Recommended
I.
Background
The
ITC
was
established
by
section
4(
e)
of
TSCA
``
to
make
recommendations
to
the
Administrator
respecting
the
chemical
substances
and
mixtures
to
which
the
Administrator
should
give
priority
consideration
for
the
promulgation
of
a
rule
for
testing
under
section
4(
a)....
At
least
every
six
months...,
the
Committee
shall
make
such
revisions
to
the
Priority
Testing
List
as
it
determines
to
be
necessary
and
transmit
them
to
the
Administrator
together
with
the
Committee's
reasons
for
the
revisions''
(
Public
Law
94
 
469,
90
Stat.
2003
et
seq.,
15
U.
S.
C.
2601
et
seq.).
Since
its
creation
in
1976,
the
ITC
has
submitted
46
semi­
annual
(
May
and
November)
Reports
to
the
EPA
Administrator
transmitting
the
Priority
Testing
List
and
its
revisions.
ITC
Reports
are
available
from
the
ITC's
web
site
(
http://
www.
epa.
gov/
opptintr/
itc)
within
a
few
days
of
submission
to
the
Administrator
and
from
http://
www.
epa.
gov/
fedrgstr
after
publication
in
the
Federal
Register.
The
ITC
meets
monthly
and
produces
its
revisions
to
the
Priority
Testing
List
with
administrative
and
technical
support
from
the
ITC
staff,
ITC
members
and
their
U.
S.
Government
organizations,
and
contract
support
provided
by
EPA.
ITC
members
and
staff
are
listed
at
the
end
of
this
Report.

II.
TSCA
Section
8
Reporting
A.
TSCA
section
8
rules.
Following
receipt
of
the
ITC's
Report
(
and
the
revised
Priority
Testing
List)
by
the
EPA
Administrator,
the
EPA's
Office
of
Pollution
Prevention
and
Toxics
(
OPPT)
promulgates
TSCA
section
8(
a)
PAIR
and
TSCA
section
8(
d)
HaSD
reporting
rules
for
chemicals
added
to
the
Priority
Testing
List.
These
rules
require
producers
and
importers
of
chemicals
recommended
by
the
ITC
to
submit
production
and
exposure
reports
under
TSCA
section
8(
a)
and
producers,
importers,
and
processors
of
chemicals
recommended
by
the
ITC
to
submit
unpublished
health
and
safety
studies
under
TSCA
section
8(
d).
These
rules
are
automatically
promulgated
by
OPPT
unless
otherwise
requested
by
the
ITC.
B.
ITC's
use
of
TSCA
section
8
and
``
other
information.''
The
ITC
reviews
the
TSCA
section
8(
a)
PAIR
reports,
TSCA
section
8(
d)
HaSD
studies
and
``
other
information''
that
becomes
available
after
the
ITC
adds
chemicals
to
the
Priority
Testing
List.
``
Other
information''
includes
TSCA
section
4(
a)
and
4(
d)
studies,
TSCA
section
8(
c)
submissions,
TSCA
section
8(
e)
``
substantial
risk''
notices,
``
For
Your
Information''
(
FYI)
submissions,
unpublished
data
submitted
to
and
from
U.
S.
Government
organizations
represented
on
the
ITC,
published
papers,
as
well
as
use,
exposure,
effects,
and
persistence
data
that
are
voluntarily
submitted
to
the
ITC
by
manufacturers,
importers,
processors,
and
users
of
chemicals
recommended
by
the
ITC.
The
ITC
reviews
this
information
and
determines
if
data
needs
should
be
revised,
if
chemicals
should
be
removed
from
the
Priority
Testing
List
or
if
recommendations
should
be
changed
to
designations.
C.
Promoting
more
efficient
use
of
information
submission
resources.
The
Voluntary
Information
Submissions
Innovative
Online
Network
(
VISION)
is
accessible
through
the
world
wide
web
(
http://
www.
epa.
gov/
opptintr/
itc/
vision.
htm).
VISION
includes
the
VISP
and
links
to
the
TSCA
Electronic
HaSD
Reporting
Form
(
http://
www.
epa.
gov/
opptintr/.
er/
hasd.
htm).
The
EPA
recently
revised
section
3.2
of
the
TSCA
Electronic
HaSD
Reporting
Form
in
response
to
ITC
requests
to
provide
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3,
2001
/
Notices
more
details
on
requested
use
and
exposure
information
(
see
46th
Report).
The
VISP
provides
examples
of
data
needed
by
ITC
member
U.
S.
Government
organizations,
examples
of
studies
that
should
not
be
submitted,
the
milestones
for
submitting
information,
guidelines
for
using
the
TSCA
Electronic
HaSD
Reporting
Form
and
instructions
for
electronically
submitting
full
studies.
The
TSCA
Electronic
HaSD
Reporting
Form
can
be
used
to
provide
electronic
information
on
ITC
voluntary
submissions,
TSCA
section
8(
d)
studies
(
to
meet
data
needs
of
the
ITC
member
U.
S.
Government
organizations),
FYI
submissions,
and
TSCA
section
8(
e)
studies.
The
ITC
encourages
chemical
producers,
importers,
processors,
and
users
to
voluntarily
provide
electronic
information
via
VISION
on
chemicals
for
which
the
ITC
is
soliciting
voluntary
information
and
to
establish
a
dialogue
with
the
ITC
to
discuss
needed
data.
To
enhance
visibility,
the
ITC
will
be
adding
all
chemicals
to
the
Priority
Testing
List
for
which
it
is
voluntarily
soliciting
information
along
with
a
request
that
EPA
not
immediately
promulgate
TSCA
section
8(
a)
PAIR
and
section
8(
d)
HaSD
reporting
rules.
If
the
ITC
does
not
receive
voluntary
electronic
information
submissions
to
meet
its
data
needs
according
to
the
procedures
in
VISP,
the
ITC
may
then
request
that
EPA
promulgate
TSCA
section
8(
a)
PAIR
and
section
8(
d)
HaSD
reporting
rules
to
determine
if
there
are
unpublished
data
to
meet
those
needs.
The
ITC
strongly
encourages
those
companies
that
must
respond
to
a
TSCA
section
8(
d)
HaSD
reporting
rule
to
provide
data
by
using
the
TSCA
Electronic
HaSD
Reporting
Form.
D.
Requests
related
to
promulgation
of
TSCA
section
8(
a)
PAIR
and
section
8(
d)
HaSD
reporting
rules.
In
this
Report,
the
ITC
is
asking
the
EPA
to
promulgate
TSCA
section
8(
a)
PAIR
and
section
8(
d)
HaSD
reporting
rules
for
37
indium
chemicals;
pentachlorothiophenol;
tetrachloropyrocatechol;
p­
toluidine,
5­
chloro­
.
alpha.,.
alpha.,.
alpha.­
trifluoro­
2­
nitro­
N­
phenyl;
benzoic
acid,
3­[
2­
chloro­
4­(
trifluoromethyl)
phenoxy]­,
2­
ethoxy­
1­
methyl­
2­
oxo;
and
8
nonylphenol
polyethoxylate
degradation
products.
Reporting
rules
are
being
requested
for
pentachlorothiophenol;
tetrachloropyrocatechol;
p­
toluidine,
5­
chloro­.
alpha.,.
alpha.,.
alpha.­
trifluoro­
2­
nitro­
N­
phenyl;
benzoic
acid,
3­[
2­
chloro­
4­(
trifluoromethyl)
phenoxy]­,
2­
ethoxy­
1­
methyl­
2­
oxo;
and
the
8
nonylphenol
polyethoxylate
degradation
products
because
needed
information
was
not
provided
in
response
to
the
voluntary
information
solicitations
published
in
the
46th
Report.
At
this
time,
the
ITC
is
requesting
that
EPA
not
promulgate
TSCA
section
8(
a)
PAIR
and
section
8(
d)
HaSD
reporting
rules
for
the
3
chloroalkenes
(
1,3­
butadiene,
1,1,2,3,4­
pentachloro­
4­(
1­
methylethoxy)­;
3­
butenoic
acid,
2,2,3,4,4­
pentachloro­;
and
3­
butenoic
acid,
2,2,3,4,4­
pentachloro­
butyl
ester)
to
allow
chloroalkenes
producers,
importers,
processors,
and
users
an
opportunity
to
voluntarily
provide
the
requested
information.

III.
ITC's
Activities
During
this
Reporting
Period
(
May
to
October
2000):
Information
Solicitations
In
its
46th
Report,
the
ITC
discussed
its
strategies
to
screen
chemicals
for
persistence
and
bioconcentration
potential
(
http://
www.
epa.
gov/
opptintr/
itc).
These
strategies
are
referred
to
as
Degradation
Effects
Bioconcentration
Information
Testing
Strategies
(
DEBITS).
DEBITS
provides
a
means
to
prioritize
chemicals
based
on
degradation,
ecological,
or
human
health
effects
and
bioconcentration
information.
During
this
reporting
period,
the
ITC
continued
to
focus
its
efforts
on
structural
classes
of
chemicals
from
a
subset
of
42
moderate
production
volume
(
MPV)
chemicals
(
production/
importation
volumes
between
100,000
and
1,000,000
pounds)
with
estimated
or
measured
bioconcentration
factors
(
BCFs)
>
250
and
about
70
structurally
related
non­
MPV
chemicals
(
also
with
BCFs
>
250).
In
its
46th
Report,
the
ITC
solicited
information
on
three
such
structural
classes:
1.
Polychlorophenols
and
polychlorobenzenethiols,
2.
Chlorotrifluoromethylphenoxy
benzenes,
and
3.
Perfluorinated
chemicals.
During
this
reporting
period,
the
ITC
continued
its
review
of
chemicals
with
potential
to
persist
and
bioconcentrate
and
decided
to
solicit
information
on
chloroalkenes.
The
ITC
is
seeking
information
on
uses,
exposures,
health
effects,
and
ecological
effects
from
the
manufacturers,
importers,
and
processors
of
chloroalkenes.
The
ITC
is
requesting
that
solicited
information
be
electronically
submitted
before
February
28,
2001,
consistent
with
the
90­
day
milestone
of
the
VISP
(
http://
www.
epa.
gov/
opptintr/
itc/
visp.
htm)
for
submitting
data
through
the
TSCA
Electronic
HaSD
Reporting
Form.
DEBITS
will
continue
to
be
used
to
prioritize
chemicals
with
potential
to
persist
and
bioconcentrate.
IV.
Revisions
to
the
TSCA
Section
4(
e)
Priority
Testing
List:
Chemicals
Added
to
the
Priority
Testing
List
A.
Indium
Chemicals
1.
Recommendation.
Indium
chemicals
are
being
added
to
the
Priority
Testing
List
to
obtain
importation,
production,
use,
exposure,
and
health
effects
information
to
meet
U.
S.
Government
data
needs.
2.
Rationales
for
recommendation.
There
is
clear
evidence
that
indium
phosphide
causes
tumors
in
rats
and
mice.
As
a
result,
indium
phosphide
and
other
indium
chemicals
are
considered
to
be
potentially
carcinogenic
to
humans.
Use
of
indium
chemicals
in
the
semiconductor
and
other
industries
may
be
increasing.
Existing
exposure
limits
may
not
be
adequate
to
protect
workers
exposed
to
indium
phosphide
and
other
indium
chemicals
from
an
increased
risk
of
lung
cancer.
3.
Supporting
information.
In
a
2­
year
inhalation
study
there
was
clear
evidence
of
carcinogenic
activity
of
indium
phosphide
(
Chemical
Abstract
Service
number
(
CAS
No.)
22398
 
80
 
7)
in
male
and
female
F344/
N
rats
and
male
and
female
B6C3F1
mice
(
http://
ntp­
server.
niehs.
nih.
gov/
htdocs/
Results_
Status/
Resstati/
M882472.
Html).
In
this
study,
the
incidence
of
benign
and
malignant
neoplasms
were
increased
in
the
lungs
of
male
and
female
rats
and
mice
at
doses
of
0.03,
0.1,
and
0.3
milligram/
meter3
(
mg/
m3).
There
was
also
an
exposure­
related
increase
in
the
incidence
of
benign
and
malignant
neoplasms
of
the
liver
in
male
and
female
mice.
For
indium
and
certain
indium
chemicals,
the
National
Institute
for
Occupational
Safety
and
Health's
(
NIOSH)
Recommended
Exposure
Limit
(
REL),
the
American
Council
of
Government
Industrial
Hygienists
(
ACGIH)
threshold
limit
value
(
TLV),
and
the
Occupational
Safety
and
Health
Administration's
(
OSHA)
Permissible
Exposure
Limit
(
PEL)
for
construction
and
shipyard
industries
is
0.1
mg/
m3.
The
current
occupational
exposure
limits
may
not
be
adequate
to
protect
workers
exposed
to
indium
phosphide
and
other
indium
chemicals
from
increased
risk
of
lung
cancer,
because
benign
and
malignant
neoplasms
were
increased
in
the
lungs
of
both
sexes
of
rats
and
mice
at
doses
lower
than
the
PEL,
REL,
and
TLV.
Furthermore,
experimental
studies
in
hamsters
suggest
that
indium
arsenide
may
induce
effects
in
the
lung
comparable
to
indium
phosphide.
These
studies
raise
the
concern
for
other
indium
chemicals
and
their
potential
health
effects.

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Federal
Register
/
Vol.
66,
No.
64
/
Tuesday,
April
3,
2001
/
Notices
The
indium
chemicals
are
believed
to
be
increasingly
used
in
the
manufacture
of
semiconductors,
injection
lasers,
solar
cells,
photodiodes,
and
lightemitting
diodes.
Worker
exposures
may
occur
during
manufacturing
and
handling
of
these
materials.
However,
there
are
no
publicly
available
reports
in
the
literature
that
assess
workplace
exposures
to
indium
phosphide
or
other
indium
chemicals.
4.
Information
needs.
The
ITC
needs:
i.
Recent
non­
CBI
estimates
of
annual
production
or
importation
volume
data
and
trends,
and
use
information,
including
percentages
of
production
or
importation
that
are
associated
with
different
uses;
ii.
Estimates
of
the
number
of
humans
and
concentrations
of
indium
chemicals
to
which
humans
may
be
exposed
in
each
relevant
use,
manufacturing,
or
processing
scenario;
iii.
Health
effects
data
including
pharmacokinetics,
genotoxicity,
subchronic
toxicity,
reproductive,
and
developmental
toxicity,
carcinogenicity
and
any
human
data
from
occupationally
exposed
workers.
The
ITC
seeks
this
information
in
order
to
adequately
assess
the
extent
and
degree
of
exposure
and
potential
hazard
associated
with
the
indium
chemicals.
Information
is
requested
on
the
37
indium­
containing
chemicals
in
Table
2
of
this
unit.
Manufacturers,
processors,
and
users
of
indium
chemicals
are
encouraged
to
provide
importation,
production,
use,
exposure,
and
health
effects
information
using
the
TSCA
Electronic
HaSD
Reporting
Form
(
http://
www.
epa.
gov/
opptintr/.
er/
hasd.
htm).

TABLE
2.
 
INDIUM
CHEMICALS
BEING
ADDED
TO
THE
PRIORITY
TESTING
LIST
CAS
No.
Chemical
name
923
 
34
 
2
.....
Triethylindium
1303
 
11
 
3
...
Indium
arsenide
1312
 
41
 
0
...
Indium
antimonide
1312
 
43
 
2
...
Indium
(
III)
oxide
1312
 
45
 
4
...
Indium
(
III)
telluride
4194
 
69
 
8
...
Indium
(
III)
citrate
7440
 
74
 
6
...
Indium
7783
 
52
 
0
...
Indium
(
III)
fluoride
10025
 
82
 
8
Indium
(
III)
chloride
12018
 
95
 
0
Copper
indium
diselenide
12030
 
14
 
7
Indium
(
II)
sulfide
12030
 
24
 
9
Indium
(
III)
sulfide
12056
 
07
 
4
Indium
selenide
12672
 
70
 
7
Indium
chloride
12672
 
71
 
8
Indium
(
I)
oxide
13464
 
82
 
9
Indium
(
III)
sulfate
13510
 
35
 
5
Indium
(
III)
iodide
13770
 
61
 
1
Indium
(
III)
nitrate
13966
 
94
 
4
Indium
(
I)
iodide
14166
 
78
 
0
Indium
(
III)
fluoride
14280
 
53
 
6
Indium
(
I)
bromide
14405
 
45
 
9
Indium
tris(
acetylacetonate)
TABLE
2.
 
INDIUM
CHEMICALS
BEING
ADDED
TO
THE
PRIORITY
TESTING
LIST
 
Continued
CAS
No.
Chemical
name
20661
 
21
 
6
Indium
(
III)
hydroxide
22398
 
80
 
7
Indium
(
I)
phosphide
25114
 
58
 
3
Indium
(
III)
acetate
25617
 
98
 
5
Indium
nitride
50926
 
11
 
9
Indium
tin
oxide
55326
 
87
 
9
Indium
hydroxide
71243
 
84
 
0
Indium
tin
oxide
13465
 
09
 
3
Indium
(
III)
bromide
13465
 
10
 
6
Indium
(
I)
chloride
13709
 
93
 
8
Indium
(
III)
borate
27765
 
48
 
6
Indium
(
III)
tetrafluoroborate
66027
 
93
 
8
Indium
(
III)
sulfamate
66027
 
94
 
9
Hydroxybis(
trifluoroacetato­
,
O)
indium
67816
 
06
 
2
Indium
(
III)
2­
ethylhexanoate
68310
 
35
 
0
Indium
(
III)
neodecanoate
B.
Chloroalkenes
1.
Recommendation.
Three
chloroalkenes
are
being
added
to
the
Priority
Testing
List
to
obtain
information
on
uses,
exposures,
environmental
releases,
pharmacokinetics,
subchronic
toxicity,
mutagenicity,
reproductive
and
developmental
effects,
carcinogenicity,
and
ecological
effects.
At
this
time,
the
ITC
is
requesting
that
EPA
not
promulgate
TSCA
section
8(
a)
PAIR
and
section
8(
d)
HaSD
reporting
rules
for
these
chemicals
in
order
to
allow
chloroalkenes
producers,
importers,
processors,
and
users
an
opportunity
to
voluntarily
provide
the
requested
information.
2.
Rationales
for
recommendation.
Two
chloroalkenes
are
believed
to
be
produced
in
substantial
amounts
and
are
predicted
to
persist
and
bioconcentrate
in
the
environment.
The
third
chloroalkene
is
a
likely
hydrolysis
product
of
one
of
the
other
chloroakenes.
All
three
chemicals
present
suspicion
of
toxicity
based
either
on
mutagenicity
data
or
shared
structural
similarities
with
hexachloro­
1,3­
butadiene.
3.
Supporting
information.
Chloroalkenes
under
review
include
4
chemicals:
Hexachloro­
1,3­
butadiene
(
CAS
No.
87
 
68
 
3);
1,3­
butadiene,
1,1,2,3,4­
pentachloro­
4­(
1­
methylethoxy)­
(
CAS
No.
68334
 
67
 
8);
3­
butenoic
acid,
2,2,3,4,4­
pentachlorobutyl
ester
(
CAS
No.
75147
 
20
 
9);
and
2,2,3,4,4­
pentachloro­
3­
butanoic
acid
(
CAS
No.
85743
 
61
 
9).
All
except
the
2,2,3,4,4­
pentachloro­
3­
butenoic
acid
meet
the
DEBITS
criteria
and
have
BCFs
>
250.
However,
2,2,3,4,4­
pentachloro­
3­
butenoic
acid
is
a
hydrolysis
product
of
3­
butenoic
acid,
2,2,3,4,4­
pentachlorobutyl
ester.
The
ITC
is
not
soliciting
information
on
hexachloro­
1,3­
butadiene
because
data
are
being
developed
under
the
Organization
for
Economic
Cooperation
and
Development
(
OECD)
Screening
Information
Data
Set
(
SIDS)
program
(
http://
www.
oecd.
org//
ehs/
guide/
sd97­
1.
htm).
Hexachloro­
1,3­
butadiene
was
included
to
provide
opportunities
to
develop
Structure
Activity
Relationships
(
SARs).
1,3­
Butadiene,
1,1,2,3,4­
pentachloro­
4­(
1­
methylethoxy)­
meets
the
DEBITS
criteria
of
ultimate
predicted
aerobic
biodegradation
rate
of
>
2­
3
months
and
estimated
log
octanol­
water
partition
coefficient
(
log
P)
ranging
from
3
to
6.
1,3­
Butadiene,
1,1,2,3,4­
pentachloro­
4­
(
1­
methylethoxy)­
is
a
MPV
chemical
with
a
log
P
of
5.14
and
estimated
BCF
of
509.
The
only
health
effects
data
for
1,3­
butadiene,
1,1,2,3,4­
pentachloro­
4­
(
1­
methylethoxy)­
were
from
acute
toxicity
tests
in
rats
that
estimated
the
LD50
to
be
1,210
mg/
kilogram
(
kg)
body
weight
(
Mallinckrodt,
1978a).
No
ecological
effects
data
were
obtained
for
this
chemical.
1,3­
Butadiene,
1,1,2,3,4­
pentachloro­
4­(
1­
methylethoxy)­
is
structurally
similar
to
hexachloro­
1,3­
butadiene
and,
therefore,
may
share
some
common
metabolic
pathways
and
related
toxicities.
Hexachloro­
1,3­
butadiene
is
known
to
be
metabolically
converted
by
glutathione
S­
transferase
to
the
glutathione
conjugate,
and
then
to
a
cysteine
sulfoxide,
which
is
cytotoxic
to
the
kidney
proximal
tubular
cells.
This
metabolic
activation
is
believed
to
be
responsible
for
the
nephrotoxicity
associated
with
the
chemical.
3­
Butenoic
acid,
2,2,3,4,4­
pentachloro­
butyl
ester
is
another
MPV
chemical
with
BCF>
250.
It
has
an
estimated
log
P
of
4.42,
and
an
estimated
BCF
of
1797.
There
are
no
ecological
effects
data
for
3­
butenoic
acid,
2,2,3,4,4­
pentachloro­
butyl
ester.
Acute
toxicity
and
genotoxicity
studies
were
available
for
the
chemical.
The
rat
oral
LD50
value
was
2.09
gram
(
g)/
kg
body
weight
(
Mallinckrodt,
1978b).
Negative
results
were
obtained
in
a
reverse
mutation
assay
using
Salmonella
typhimurium
(
TA­
1535,
TA­
1537,
TA­
1538,
TA­
98,
and
TA­
100)
and
Saccharomyces
cerevisiae
(
D4)
with
or
without
metabolic
activation
(
Mallinckrodt,
1984a).
There
was
no
significant
increase
in
6­
thioguanine
resistant
mutation
frequency
in
Chinese
hamster
ovary
cells
with
or
without
metabolic
activation
(
Mallinckrodt,
1984c).
There
was
a
positive
response
in
an
Escherichia
coli
microsuspension
assay
for
DNA
damage
and
in
the
frequency
of
sister
chromatid
exchange
and
chromosomal
aberrations
from
Chinese
hamster
ovary
cells
(
Mallinckrodt,
1984b,
d,
e).

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Federal
Register
/
Vol.
66,
No.
64
/
Tuesday,
April
3,
2001
/
Notices
3­
Butenoic
acid,
2,2,3,4,4­
pentachloro­
butyl
ester
is
likely
hydrolyzed
to
2,2,3,4,4­
pentachloro­
3­
butenoic
acid.
The
latter
chemical
has
a
predicted
aerobic
biodegradation
rate
of
>
2
 
3
months,
an
estimated
log
P
of
3.38,
an
estimated
BCF
of
3,
but
its
production
volume
is
less
than
10,000
pounds
per
annum.
Like
its
butyl
ester,
2,2,3,4,4­
pentachloro­
3­
butenoic
acid
has
some
genotoxic
activity.
It
caused
reverse
mutation
in
Salmonella
typhimurium
strain
TA100
both
with
and
without
metabolic
activation
(
Reichert
et
al.
1984)
and
induced
both
unscheduled
DNA
synthesis
(
with
and
without
activation)
and
morphological
transformation
in
Syrian
hamster
embryo
fibroblasts
(
Schiffmann
et
al.
1984).
3­
Butenoic
acid,
2,2,3,4,4­
pentachloro­
butyl
ester
presents
a
suspicion
of
toxicity
based
on
existing
data
and
its
metabolic
relationship
and
structural
similarity
to
2,2,3,4,4­
pentachloro­
3­
butenoic
acid.
Information
Profiles
for
1,3­
butadiene,
1,1,2,3,4­
pentachloro­
4­(
1­
methylethoxy)­,
3­
butenoic
acid,
2,2,3,4,4­
pentachloro­
butyl
ester
and
2,2,3,4,4­
pentachloro­
3­
butenoic
acid
will
be
available
on
the
ITC's
web
site
(
http://
www.
epa.
gov/
opptintr/
itc).
4.
Information
needs.
The
ITC
needs
information
on
uses,
exposures,
environmental
releases,
pharmacokinetics,
subchronic
toxicity,
mutagenicity,
reproductive
and
developmental
effects,
carcinogenicity,
and
ecological
effects
for
1,3­
butadiene,
1,1,2,3,4­
pentachloro­
4­(
1­
methylethoxy)­;
3­
butenoic
acid,
2,2,3,4,4­
pentachloro­
and
3­
butenoic
acid,
2,2,3,4,4­
pentachloro­
butyl
ester.
In
addition,
the
ITC
needs
hydrolysis
rate
data
for
3­
butenoic
acid,
2,2,3,4,4­
pentachloro­
butyl
ester.
If
the
information
is
not
voluntarily
submitted
in
accordance
with
VISP,
the
ITC
will
ask
EPA
to
promulgate
TSCA
section
8(
a)
PAIR
and
section
8(
d)
HaSD
reporting
rules
in
a
subsequent
Report.

C.
Polychlorophenols
and
Polychlorobenzenethiols
1.
Recommendation.
Pentachlorothiophenol
(
CAS
No.
133
 
49
 
3)
and
tetrachloropyrocatechol
(
CAS
No.
1198
 
55
 
6)
are
being
added
to
the
Priority
Testing
List
so
that
final
TSCA
section
8(
a)
and
8(
d)
rules
will
be
promulgated
by
the
EPA.
2.
Rationale
for
recommendation.
Information
solicited
in
the
46th
Report
for
pentachlorothiophenol
and
tetrachloropyrocatechol
was
not
provided
to
the
ITC.
3.
Supporting
information.
Pentachlorothiophenol
and
tetrachloropyrocatechol
meet
the
DEBITS
criteria
for
persistence
and
bioconcentration.
Pentachlorothiophenol
has
an
estimated
BCF
of
7066.
Tetrachloropyrocatechol's
measured
BCF
ranges
from
316
 
5011.
There
are
no
publicly
available
ecological
effects
and
limited
health
effects
data
for
pentachlorothiophenol.
Tetrachloropyrocatechol
has
been
shown
to
be
highly
toxic
to
fish
but
little
is
known
about
health
effects
in
mammalian
species.
Pentachlorothiophenol
and
tetrachloropyrocatechol
are
metabolites
of
pentachlorophenol.
Pentachlorothiophenol
has
also
been
detected
in
the
urine
of
human
populations
exposed
to
hexachlorobenzene.
The
carcinogenicity,
reproductive
effects
and
developmental
toxicities
of
hexachlorobenzene
and
pentachlorophenol
are
well
known.
The
ITC
believes
that
pentachlorothiophenol
and
tetrachloropyrocatechol
present
a
suspicion
of
toxicity
given
the
metabolic
relationship
and
structural
similarity
to
hexachlorobenzene
and
pentachlorophenol.
Detailed
information
supporting
the
addition
of
pentachlorothiophenol
and
tetrachloropyrocatechol
to
the
Priority
Testing
List
was
provided
in
the
ITC's
46th
Report.
4.
Information
needs.
The
ITC
needs
information
on
uses
and
data
on
exposures,
environmental
releases,
pharmacokinetics,
subchronic
toxicity,
reproductive
and
developmental
effects,
carcinogenicity,
and
ecological
effects
for
pentachlorothiophenol
and
tetrachloropyrocatechol.
The
ITC
also
needs
mutagenicity
data
for
pentachlorothiophenol.
Manufacturers,
processors,
and
users
of
these
chemicals
are
encouraged
to
provide
importation,
production,
use,
exposure,
and
health
effects
information
using
the
TSCA
Electronic
HaSD
Reporting
Form
(
http:/
/
www.
epa.
gov/
opptintr/.
er/
hasd.
htm).

D.
Chlorotrifluoromethylphenoxy
Benzenes
1.
Recommendation.
p­
Toluidine,
5­
chloro­
.
alpha.,.
alpha.,.
alpha.­
trifluoro­
2­
nitro­
N­
phenyl
(
CAS
No.
1806
 
24
 
2)
and
benzoic
acid,
3­[
2­
chloro­
4­
(
trifluoromethyl)
phenoxy]­,
2­
ethoxy­
1­
methyl­
2­
oxo
(
CAS
No.
88185
 
2
 
2)
are
being
added
to
the
Priority
Testing
List
so
that
final
TSCA
section
8(
a)
and
8(
d)
rules
will
be
promulgated
by
the
EPA.
2.
Rationale
for
recommendation.
Information
solicited
in
the
46th
Report
for
p­
toluidine,
5­
chloro­
.
alpha.,.
alpha.,.
alpha.­
trifluoro­
2­
nitro­
N­
phenyl
and
benzoic
acid,
3­[
2­
chloro­
4­(
trifluoromethyl)
phenoxy]­,
2­
ethoxy­
1­
methyl­
2­
oxo
was
not
provided
to
the
ITC.
3.
Supporting
information.
Eight
chlorotrifluoromethylphenoxy
benzenes
were
listed
in
the
ITC's
46th
Report.
All
were
estimated
to
persist
and
seven
had
estimated
BCFs
>
250.
Six
chlorotrifluoromethylphenoxy
benzenes
were
highly
toxic
to
fish.
One
member
of
this
class,
Lactofen
is
a
well­
studied
herbicide,
considered
by
the
U.
S.
EPA
to
be
a
probable
human
carcinogen.
As
a
result
of
the
oncogenicity
and
other
adverse
health
effects
associated
with
Lactofen,
there
is
a
heightened
concern
for
potential
toxicity
of
the
other
chlorotrifluoromethylphenoxy
benzenes
which
have
not
been
extensively
investigated.
Information
was
solicited
for
4
of
8
chlorotrifluoromethylphenoxy
benzenes
listed
in
the
ITC's
46th
Report.
Lactofen
and
three
HPV
chemicals
were
not
included
in
the
solicitation.
In
response
to
the
solicitation,
the
ITC
learned
that
one
of
these
chemicals,
phenol,
5­(
2­
chloro­
4­
(
trifluoromethyl)
phenoxy)­
2­
nitro­
(
CAS
No.
42874
 
63
 
5)
is
a
process
intermediate
that
is
not
isolated
from
storage
nor
packaged
for
distribution
in
commerce.
Another
chlorotrifluoromethylphenoxy
benzene
for
which
information
was
solicited,
benzene,
2­
chloro­
1­(
3­
methylphenoxy)­
4­(
trifluoromethyl)­
(
CAS
No.
42874
 
96
 
4)
was
previously
added
to
a
TSCA
section
8(
d)
HaSD
reporting
rule
as
a
result
of
its
addition
to
the
Priority
Testing
List
in
the
ITC's
29th
Report
(
56
FR
67424,
December
30,
1991).
Since
it
is
already
included
in
a
TSCA
section
8(
d)
HaSD
reporting
rule
(
47
FR
38780,
October
4,
1982)
and
the
reporting
period
is
10
years
in
length,
benzene,
2­
chloro­
1­(
3­
methylphenoxy)­
4­
(
trifluoromethyl)­
does
not
have
to
be
added
to
the
Priority
Testing
List
to
facilitate
that
action.
The
other
two
chlorotrifluoromethylphenoxy
benzenes,
p­
toluidine,
5­
chloro­
.
alpha.,.
alpha.,.
alpha.­
trifluoro­
2­
nitro­
N­
phenyl
and
benzoic
acid,
3­[
2­
chloro­
4­(
trifluoromethyl)
phenoxy]­,
2­
ethoxy­
1­
methyl­
2­
oxo
are
being
added
to
the
Priority
Testing
List,
because
no
information
was
submitted
in
response
to
the
46th
Report
solicitation.
Detailed
information
supporting
the
addition
of
p­
toluidine,
5­
chloro­
.
alpha.,.
alpha.,.
alpha.­
trifluoro­
2­
nitro­
N­
phenyl
and
benzoic
acid,
3­[
2­
chloro­
4­(
trifluoromethyl)
phenoxy]­,
2­
ethoxy­
1­
methyl­
2­
oxo
to
the
Priority
Testing
List
was
provided
in
the
ITC's
46th
Report.
4.
Information
needs.
The
ITC
needs
information
on
uses,
exposures,
environmental
releases,
ecological
effects,
pharmacokinetics,
subchronic
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Federal
Register
/
Vol.
66,
No.
64
/
Tuesday,
April
3,
2001
/
Notices
toxicity,
reproductive
and
developmental
effects,
mutagenicity,
and
carcinogenicity
for
p­
toluidine,
5­
chloro­.
alpha.,.
alpha.,.
alpha.­
trifluoro­
2­
nitro­
N­
phenyl
and
benzoic
acid,
3­[
2­
chloro­
4­(
trifluoromethyl)
phenoxy]­,
2­
ethoxy­
1­
methyl­
2­
oxo.

V.
References
1.
Mallinckrodt
Inc.
1978a.
Initial
Submission:
Acute
oral
toxicity
(
LD50)
test
in
rats
(
Final
Report)
with
cover
letter
dated
02/
27/
92;
10/
13/
78;
EPA
Doc.
No.
88
 
920001282;
Microfiche
No.
OTS0535871.
2.
Mallinckrodt
Inc.
1978b.
Initial
Submission:
Letter
submitting
one
enclosed
acute
toxicity
series
study
with
cover
letter
dated
02/
27/
92.
EPA
Doc.
No.
88
 
920001280;
Microfiche
No.
OTS0535869.
3.
Mallinckrodt
Inc.
1984a.
Mutagenicity
evaluation
of
M­
388­
48A
in
the
Ames
Salmonella/
microsome
plate
test
with
cover
letter
dated
12/
28/
84;
03/
01/
78;
EPA
Doc.
No.
FYI­
OTS
 
0185
 
0376;
Microfiche
No.
OTS0000376
 
0.
4.
Mallinckrodt
Inc.
1984b.
Escherichia
coli
microsuspension
assay
for
DNA
damage
with
compound
M276;
02/
23/
84;
EPA
Doc.
No.
FYI­
OTS­
0185
 
0376;
Microfiche
No.
OTS0000376
 
0.
5.
Mallinckrodt
Inc.
1984c.
CHO/
HGPRT
forward
mutation
assay
M276;
02/
23/
84;
EPA
Doc.
No.
FYI­
OTS­
0185
 
0376;
Microfiche
No.
OTS0000376
 
0.
6.
Mallinckrodt
Inc.
1984d.
In
vitro
sister
chromatid
exchange
in
Chinese
hamster
ovary
cells
with
M276;
07/
13/
84;
EPA
Doc.
No.
FYI­
OTS­
0185
 
0376;
Microfiche
No.
OTS0000376
 
0.
7.
Mallinckrodt
Inc.
1984e.
In
vitro
chromosomal
aberrations
in
Chinese
hamster
ovary
cells
with
M276;
12/
19/
84;
EPA
Doc.
No.
FYI­
OTS­
0185
 
0376;
Microfiche
No.
OTS0000376
 
0.
8.
Reichert
D,
Neudecker
T,
Sche 
utz
S.
1984.
Mutagenicity
of
hexachlorobutadiene,
perchlorobutenoic
acid
and
perchlorobutenoic
acid
chloride.
Mutation
Research.
137:
89
 
94.
9.
Schiffmann
D,
Reichert
D,
Henschler
D.
1984.
Induction
of
morphological
transformation
and
unscheduled
DNA
synthesis
in
Syrian
hamster
embryo
fibroblasts
by
hexachlorobutadiene
and
its
putative
metabolite
pentachlorobutenoic
acid.
Cancer
Letters.
23:
297
 
306.

VI.
TSCA
Interagency
Testing
Committee
Statutory
Organizations
and
Their
Representatives
Council
on
Environmental
Quality
Vacant
Department
of
Commerce
National
Institute
of
Standards
and
Technology
Robert
Huie,
Member
Barbara
C.
Levin,
Alternate
National
Oceanographic
and
Atmospheric
Administration
Teri
Rowles,
Alternate
Environmental
Protection
Agency
Paul
Campanella,
Member
David
R.
Williams,
Alternate
National
Cancer
Institute
Vacant
National
Institute
of
Environmental
Health
Sciences
Scott
Masten,
Member
William
Eastin,
Alternate
National
Institute
for
Occupational
Safety
and
Health
Albert
E.
Munson,
Member
Mark
Toraason,
Alternate
National
Science
Foundation
A.
Frederick
Thompson,
Member
Marge
Cavanaugh,
Alternate
Occupational
Safety
and
Health
Administration
Val
H.
Schaeffer,
Member,
Chair
Lyn
Penniman,
Alternate
Liaison
Organizations
and
Their
Representatives
Agency
for
Toxic
Substances
and
Disease
Registry
William
Cibulas,
Member
Consumer
Product
Safety
Commission
Jacqueline
Ferrante,
Member
Treye
Thomas,
Alternate
Department
of
Agriculture
Clifford
P.
Rice,
Member
Department
of
Defense
Barbara
Larcom,
Member
Kenneth
Still,
Alternate
Jose
´
Centeno,
Alternate
Department
of
the
Interior
Barnett
A.
Rattner,
Member,
Vice
Chair
Food
and
Drug
Administration
Ronald
Lorentzen,
Member
Raju
Kammula,
Alternate
David
Hatten,
Alternate
National
Library
of
Medicine
Vera
W.
Hudson,
Member
National
Toxicology
Program
NIEHS,
FDA,
and
NIOSH
Members
Counsel
Scott
Sherlock,
OPPT,
EPA
Technical
Support
Contractor
Syracuse
Research
Corporation
ITC
Staff
John
D.
Walker,
Executive
Director
Norma
S.
L.
Williams,
Executive
Assistant
TSCA
Interagency
Testing
Committee,
Office
of
Pollution
Prevention
and
Toxics
(
7401),
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460;
telephone:
(
202)
260
 
1825;
fax:
(
202)
260
 
7895;
e­
mail
address:
williams.
norma@
epa.
gov;
url:
http://
www.
epa.
gov/
opptintr/
itc.
[
FR
Doc.
01
 
8133
Filed
4
 
2
 
01;
8:
45
am]

BILLING
CODE
6560
 
50
 
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