Document ID: EPA-HQ-OPP-2005-0157-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2007-08-29T04:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

 

OFFICE OF

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM		

DATE:  	August 9, 2007

SUBJECT:	Propylene Oxide: Screening Level Acute Dietary Exposure
Assessment for PPO Reaction Product Propylene Chlorohydrin

PC Code:	042501

DP Barcode:	D342457

REVIEWER:	Becky Daiss, Biologist				

Reregistration Branch 4

Health Effects Division (7509P)

THROUGH:	Susan Hummel, Branch Senior Scientist

Reregistration Branch 4

Health Effects Division (7509P)

TO:		Tony Kish, Product Manager

Fungicide Branch

Registration Division (7505P)

This document provides a screening level probabilistic acute dietary
exposure assessment for propylene chlorohydrin.  Propylene chlorohydrin
forms as a reaction product in commodities fumigated with propylene
oxide.  This assessment is an addendum to the Propylene Oxide Dietary
Exposure Assessment (B. Daiss, D329648, 6/30/06).  Background 

A screening level acute dietary risk assessment for propylene
chlorohydrin was conducted using the Dietary Exposure Evaluation Model
(DEEM-FCID(, Version 2.03) which uses food consumption data from the
USDA’s Continuing Surveys of Food Intakes by Individuals (CSFII) from
1994-1996 and 1998.  This assessment is considered highly conservative
based on the fact that a chronic endpoint was used in the absence of an
acute endpoint from the available toxicological data.  Data on levels of
the reaction product propylene chlorohydrin were provided in studies on
propylene oxide sterilization of nutmeats, cocoa powder, herbs and
spices, figs, prunes and raisins.  Residue distribution data from these
studies were used for the acute dietary analysis of propylene
chlorohydrin.  Percent crop treated data provided by the registrant and
verified by the Biological Economic Analysis Division were used for the
acute analyses where available.  Percent crop treated data was not
available for figs, prunes and raisins.  Therefore, 100% crop treated
was conservatively assumed for these commodities. The percent crop
treated values used for this assessment are the same as those used to
evaluate acute risk for propylene oxide.  For a more detailed
description of the methodology and input parameters used in this
assessment, please refer to the June 30, 2006 Propylene Oxide Dietary
Exposure Assessment conducted for the Propylene Oxide Reregistration
Eligibility Decision (D329648).

Toxicological Endpoint

An acute reference dose (RfD) was not established for propylene
chlorohydrin because an endpoint attributable to a single day exposure
was not identified from the available database.  Therefore, the chronic
RfD selected for propylene chlorohydrin from a two generation rat
reproduction study was used for the acute analysis.  This is an
extremely conservative endpoint for use in an acute assessment given
that the NOAEL is established from repeat dosing and is based on
decreased pup weights.  Doses and toxicological endpoints used for the
screening level acute dietary exposure scenarios are summarized in Table
1.  

Table 1. Summary of Toxicological Doses and Endpoints for Propylene
oxide for Use in Human Risk Assessments

Exposure

Scenario	Dose Used in Risk Assessment, UF 	SF and Level of Concern for
Risk Assessment	Study and Toxicological Effects

Propylene Chlorohydrin

 ADVANCE \d2 Acute Dietary	No endpoint selected

Chronic Dietary

All Populations	 ADVANCE \d2 NOAEL= 30 mg/kg/day

UF = 1000

(10x intraspecies variation, 10x interspecies extrapolation, 10x DBUF)

Chronic RfD = 0.03 mg/kg/day	 ADVANCE \d2 FQPA SF = 1X

cPAD = 

chronic RfD

 FQPA SF

= 0.03 mg/kg/day	Two-Generation Reproduction Study, Rats (NTP, 1998)

Offspring LOAEL: 65 mg/kg/day

Decreased F1 male and female pup weights at PND 14 and 21. 

UF = uncertainty factor, FQPA SF = Special FQPA safety factor, NOAEL =
no observed adverse effect  level, LOAEL = lowest observed adverse
effect level, PAD = population adjusted dose (a = acute, c = chronic)
RfD = reference dose, 

Acute Dietary Screening Analysis Exposure Results and Characterization

A probabilistic acute dietary exposure assessment was conducted for all
supported propylene oxide food uses for the general U.S. population and
various population subgroups for the propylene oxide reaction product
propylene chlorohydrin.  Since an acute RfD was not established for
propylene chlorohydrin because an endpoint attributable to a single day
exposure was not identified from the available database, the chronic RfD
was used.  Use of a chronic endpoint to assess acute dietary exposure
results in a highly conservative, screening level estimate of risk from
dietary exposure to propylene chlorohydrin that is likely to
significantly overestimate risks.  

 

The results of the DEEM acute dietary exposure analyses for propylene
chlorohydrin conducted using the chronic RfD as the toxicological
endpoint are reported in Table 2.  The DEEM acute dietary exposure
estimate for the highest exposed population subgroup, children 1-2 years
old, is 113% of the cPAD.   This assessment indicates that for all
supported commodities, the acute dietary exposure estimates for
propylene chlorohydrin are slightly above HED’s level of concern
(>100% PAD) for infants and young children.  However, given the highly
conservative nature of the assessment i.e., the use of a chronic
endpoint, use of 100% crop treated for some commodities, and use of
residue values at the earliest point of consumption, HED confidently
concludes that PCH does not present acute dietary risks of concern.

Table 2. Summary of Acute Dietary Exposure and Risk from PCH using
Chronic RfD (0.03 mg/kg/day)

Population Subgroup	cPAD (mg/kg/day)	99.9th %ile Exposure (mg/kg/day)	%
cPAD (99.9th %)

General U.S. Population	0.03	0.0101	33

All Infants (< 1 year old)

0.0330	110

Children 1-2 years old

0.3398	113

Children 3-5 years old

0.0203	68

Children 6-12 years old

0.0118	39

Youth 13-19 years old

0.0072	24

Adults 20-49 years old

0.0080	27

Females 13-49 years old

0.0104	35

Adults 50+ years old

0.0083	28

Attachments

1 - Acute DEEM Residue Input Files 

2 - Acute DEEM Results Files

3 - DEEM Residue Distribution Files

 Attachment 1 DEEM Residue Files  Propylene Chlorohydrin

U.S. Environmental Protection Agency                                
Ver. 2.02

DEEM-FCID Acute analysis for PPO

Residue file name: E:\pchacuteRDFdistribnoguar8-9-07.R98

Analysis Date 08-09-2007             Residue file dated:
08-09-2007/14:36:01/8

Reference dose: aRfD = 0.03 mg/kg bw/day  NOEL = 30 mg/kg bw/day

------------------------------------------------------------------------
--------

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1           Param #2    Param #3    Comment

  #   Code 

----- ---- ------------           ----------- ----------- ----------

  1    6   pchspicesherbs.rdf

  2    6   pchnutmeats.rdf

  3    6   pchcocoa.rdf

  4    6   pchalmonds.rdf

  5    6   pchwalnut.rdf

  6    6   pchbasil.rdf

  7    6   pchonion.rdf

  8    6   pchgarlic.rdf

  9    6   pchpepper.rdf

  10   6   pchpecan.rdf

  EPA    Crop Food Name                        Def PPO Res  Adj.Factors 
RDL  Comment

  Code    Grp                                    (ppm)       #1     #2  
Pntr

-------- ---- -------------------------------  ----------  ------ ------
---  -------

14000030 14   Almond                           300.000000   1.000  0.020
  4  

14000031 14   Almond-babyfood                  300.000000   1.000  0.020
  4  

14000040 14   Almond, oil                      300.000000   1.000  0.020
  4  

14000041 14   Almond, oil-babyfood             300.000000   1.000  0.020
  4  

19010290 19A  Basil, dried leaves

                 110-Uncooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 130-Uncooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  6  

                 210-Cooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 211-Cooked; Fresh or N/S; Baked

                                                 0.000000   1.000  0.010
     

                 212-Cooked; Fresh or N/S; Boiled

                                                 0.000000   1.000  0.010
     

                 213-Cooked; Fresh or N/S; Fried

                                                 0.000000   1.000  0.010
     

                 215-Cooked; Fresh or N/S; Boiled/baked

                                                 0.000000   1.000  0.010
     

                 221-Cooked; Frozen; Baked     300.000000   1.000  0.010
  6  

                 232-Cooked; Dried; Boiled     300.000000   1.000  0.010
  6  

                 233-Cooked; Dried; Fried      300.000000   1.000  0.010
  6  

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  6  

19010291 19A  Basil, dried leaves-babyfood

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  6  

14000590 14   Brazil nut                       300.000000   1.000  0.020
  2  

14000680 14   Butternut                        300.000000   1.000  0.020
  2  

14000810 14   Cashew                           300.000000   1.000  0.020
  2  

14000920 14   Chestnut                         300.000000   1.000  0.020
  2  

19011030 19A  Chive

                 110-Uncooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 210-Cooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 211-Cooked; Fresh or N/S; Baked

                                                 0.000000   1.000  0.010
     

                 212-Cooked; Fresh or N/S; Boiled

                                                 0.000000   1.000  0.010
     

                 213-Cooked; Fresh or N/S; Fried

                                                 0.000000   1.000  0.010
     

                 221-Cooked; Frozen; Baked     300.000000   1.000  0.010
  1  

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 242-Cooked; Canned; Boiled    300.000000   1.000  0.010
  1  

19021050 19B  Cinnamon

                 110-Uncooked; Fresh or N/S; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 130-Uncooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 210-Cooked; Fresh or N/S; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 211-Cooked; Fresh or N/S; Baked

                                               300.000000   1.000  0.010
  1  

                 212-Cooked; Fresh or N/S; Boiled

                                               300.000000   1.000  0.010
  1  

                 213-Cooked; Fresh or N/S; Fried

                                               300.000000   1.000  0.010
  1  

                 214-Cooked; Fresh or N/S; Fried/baked

                                               300.000000   1.000  0.010
  1  

                 215-Cooked; Fresh or N/S; Boiled/baked

                                               300.000000   1.000  0.010
  1  

                 221-Cooked; Frozen; Baked     300.000000   1.000  0.010
  1  

                 230-Cooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 232-Cooked; Dried; Boiled     300.000000   1.000  0.010
  1  

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

19021051 19B  Cinnamon-babyfood

                 211-Cooked; Fresh or N/S; Baked

                                               300.000000   1.000  0.010
  1  

                 230-Cooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

95001090 O    Cocoa bean, chocolate            200.000000   1.000  0.013
  3  

95001100 O    Cocoa bean, powder               200.000000   1.000  0.013
  3  

19011180 19A  Coriander, leaves

                 110-Uncooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 150-Uncooked; Cured etc; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 210-Cooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 211-Cooked; Fresh or N/S; Baked

                                                 0.000000   1.000  0.010
     

                 212-Cooked; Fresh or N/S; Boiled

                                                 0.000000   1.000  0.010
     

                 213-Cooked; Fresh or N/S; Fried

                                                 0.000000   1.000  0.010
     

                 221-Cooked; Frozen; Baked     300.000000   1.000  0.010
  1  

                 230-Cooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 232-Cooked; Dried; Boiled     300.000000   1.000  0.010
  1  

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 242-Cooked; Canned; Boiled    300.000000   1.000  0.010
  1  

                 250-Cooked; Cured etc; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 252-Cooked; Cured etc; Boiled 300.000000   1.000  0.010
  1  

                 253-Cooked; Cured etc; Fried  300.000000   1.000  0.010
  1  

19011181 19A  Coriander, leaves-babyfood       300.000000   1.000  0.010
  1  

19021190 19B  Coriander, seed

                 110-Uncooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 150-Uncooked; Cured etc; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 210-Cooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 211-Cooked; Fresh or N/S; Baked

                                                 0.000000   1.000  0.010
     

                 212-Cooked; Fresh or N/S; Boiled

                                                 0.000000   1.000  0.010
     

                 213-Cooked; Fresh or N/S; Fried

                                                 0.000000   1.000  0.010
     

                 214-Cooked; Fresh or N/S; Fried/baked

                                                 0.000000   1.000  0.010
     

                 221-Cooked; Frozen; Baked     300.000000   1.000  0.010
  1  

                 230-Cooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 231-Cooked; Dried; Baked      300.000000   1.000  0.010
  1  

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 242-Cooked; Canned; Boiled    300.000000   1.000  0.010
  1  

                 250-Cooked; Cured etc; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 252-Cooked; Cured etc; Boiled 300.000000   1.000  0.010
  1  

                 253-Cooked; Cured etc; Fried  300.000000   1.000  0.010
  1  

19021191 19B  Coriander, seed-babyfood         300.000000   1.000  0.010
  1  

19021430 19B  Dill, seed

                 150-Uncooked; Cured etc; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 210-Cooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 211-Cooked; Fresh or N/S; Baked

                                                 0.000000   1.000  0.010
     

                 212-Cooked; Fresh or N/S; Boiled

                                                 0.000000   1.000  0.010
     

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

19011440 19A  Dillweed

                 150-Uncooked; Cured etc; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 210-Cooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 211-Cooked; Fresh or N/S; Baked

                                                 0.000000   1.000  0.010
     

                 212-Cooked; Fresh or N/S; Boiled

                                                 0.000000   1.000  0.010
     

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

95001530 O    Fig                                2.000000   1.000  1.000
     

95001540 O    Fig, dried                         2.000000   1.000  1.000
     

14001550 14   Filbert                          300.000000   1.000  0.020
  2  

14001560 14   Filbert, oil                     300.000000   1.000  0.020
  2  

03001650 3    Garlic, dried

                 110-Uncooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 130-Uncooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  8  

                 210-Cooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 211-Cooked; Fresh or N/S; Baked

                                                 0.000000   1.000  0.010
     

                 212-Cooked; Fresh or N/S; Boiled

                                                 0.000000   1.000  0.010
     

                 213-Cooked; Fresh or N/S; Fried

                                                 0.000000   1.000  0.010
     

                 214-Cooked; Fresh or N/S; Fried/baked

                                                 0.000000   1.000  0.010
     

                 215-Cooked; Fresh or N/S; Boiled/baked

                                                 0.000000   1.000  0.010
     

                 221-Cooked; Frozen; Baked     300.000000   1.000  0.010
  8  

                 222-Cooked; Frozen; Boiled    300.000000   1.000  0.010
  8  

                 230-Cooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  8  

                 232-Cooked; Dried; Boiled     300.000000   1.000  0.010
  8  

                 233-Cooked; Dried; Fried      300.000000   1.000  0.010
  8  

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  8  

                 242-Cooked; Canned; Boiled    300.000000   1.000  0.010
  8  

                 250-Cooked; Cured etc; Cook Meth N/S

                                               300.000000   1.000  0.010
  8  

03001651 3    Garlic, dried-babyfood

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  8  

95001780 O    Grape, raisin                      1.000000   1.000  1.000
     

19011840 19A  Herbs, other

                 110-Uncooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 150-Uncooked; Cured etc; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 210-Cooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 211-Cooked; Fresh or N/S; Baked

                                                 0.000000   1.000  0.010
     

                 212-Cooked; Fresh or N/S; Boiled

                                                 0.000000   1.000  0.010
     

                 213-Cooked; Fresh or N/S; Fried

                                                 0.000000   1.000  0.010
     

                 215-Cooked; Fresh or N/S; Boiled/baked

                                                 0.000000   1.000  0.010
     

                 221-Cooked; Frozen; Baked     300.000000   1.000  0.010
  1  

                 230-Cooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 232-Cooked; Dried; Boiled     300.000000   1.000  0.010
  1  

                 233-Cooked; Dried; Fried      300.000000   1.000  0.010
  1  

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 242-Cooked; Canned; Boiled    300.000000   1.000  0.010
  1  

                 250-Cooked; Cured etc; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 252-Cooked; Cured etc; Boiled 300.000000   1.000  0.010
  1  

                 253-Cooked; Cured etc; Fried  300.000000   1.000  0.010
  1  

19011841 19A  Herbs, other-babyfood

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

14001850 14   Hickory nut                      300.000000   1.000  0.020
  2  

19012020 19A  Lemongrass                       300.000000   1.000  0.010
  1  

14002130 14   Macadamia nut                    300.000000   1.000  0.020
  2  

19012200 19A  Marjoram

                 110-Uncooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 130-Uncooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 210-Cooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 211-Cooked; Fresh or N/S; Baked

                                                 0.000000   1.000  0.010
     

                 212-Cooked; Fresh or N/S; Boiled

                                                 0.000000   1.000  0.010
     

                 213-Cooked; Fresh or N/S; Fried

                                                 0.000000   1.000  0.010
     

                 215-Cooked; Fresh or N/S; Boiled/baked

                                                 0.000000   1.000  0.010
     

                 221-Cooked; Frozen; Baked     300.000000   1.000  0.010
  1  

                 232-Cooked; Dried; Boiled     300.000000   1.000  0.010
  1  

                 233-Cooked; Dried; Fried      300.000000   1.000  0.010
  1  

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 242-Cooked; Canned; Boiled    300.000000   1.000  0.010
  1  

19012201 19A  Marjoram-babyfood

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

03002380 3    Onion, dry bulb, dried

                 110-Uncooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 130-Uncooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  7  

                 210-Cooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 211-Cooked; Fresh or N/S; Baked

                                                 0.000000   1.000  0.010
     

                 212-Cooked; Fresh or N/S; Boiled

                                                 0.000000   1.000  0.010
     

                 213-Cooked; Fresh or N/S; Fried

                                                 0.000000   1.000  0.010
     

                 214-Cooked; Fresh or N/S; Fried/baked

                                                 0.000000   1.000  0.010
     

                 215-Cooked; Fresh or N/S; Boiled/baked

                                                 0.000000   1.000  0.010
     

                 221-Cooked; Frozen; Baked     300.000000   1.000  0.010
  7  

                 222-Cooked; Frozen; Boiled    300.000000   1.000  0.010
  7  

                 230-Cooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  7  

                 231-Cooked; Dried; Baked      300.000000   1.000  0.010
  7  

                 232-Cooked; Dried; Boiled     300.000000   1.000  0.010
  7  

                 233-Cooked; Dried; Fried      300.000000   1.000  0.010
  7  

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  7  

                 242-Cooked; Canned; Boiled    300.000000   1.000  0.010
  7  

                 250-Cooked; Cured etc; Cook Meth N/S

                                               300.000000   1.000  0.010
  7  

03002381 3    Onion, dry bulb, dried-babyfood

                 211-Cooked; Fresh or N/S; Baked

                                                 0.000000   1.000  0.010
     

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

19012490 19A  Parsley, dried leaves

                 110-Uncooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 210-Cooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 211-Cooked; Fresh or N/S; Baked

                                                 0.000000   1.000  0.010
     

                 212-Cooked; Fresh or N/S; Boiled

                                                 0.000000   1.000  0.010
     

                 213-Cooked; Fresh or N/S; Fried

                                                 0.000000   1.000  0.010
     

                 221-Cooked; Frozen; Baked     300.000000   1.000  0.010
  1  

                 230-Cooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 232-Cooked; Dried; Boiled     300.000000   1.000  0.010
  1  

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 242-Cooked; Canned; Boiled    300.000000   1.000  0.010
  1  

19012491 19A  Parsley, dried leaves-babyfood

                 211-Cooked; Fresh or N/S; Baked

                                                 0.000000   1.000  0.010
     

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

14002690 14   Pecan                            300.000000   1.000  0.020
 10  

19022740 19B  Pepper, black and white

                 110-Uncooked; Fresh or N/S; Cook Meth N/S

                                               300.000000   1.000  0.010
  9  

                 130-Uncooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  9  

                 150-Uncooked; Cured etc; Cook Meth N/S

                                               300.000000   1.000  0.010
  9  

                 210-Cooked; Fresh or N/S; Cook Meth N/S

                                               300.000000   1.000  0.010
  9  

                 211-Cooked; Fresh or N/S; Baked

                                               300.000000   1.000  0.010
  9  

                 212-Cooked; Fresh or N/S; Boiled

                                               300.000000   1.000  0.010
  9  

                 213-Cooked; Fresh or N/S; Fried

                                               300.000000   1.000  0.010
  9  

                 214-Cooked; Fresh or N/S; Fried/baked

                                               300.000000   1.000  0.010
  9  

                 215-Cooked; Fresh or N/S; Boiled/baked

                                               300.000000   1.000  0.010
  9  

                 221-Cooked; Frozen; Baked     300.000000   1.000  0.010
  9  

                 222-Cooked; Frozen; Boiled    300.000000   1.000  0.010
  9  

                 230-Cooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  9  

                 231-Cooked; Dried; Baked      300.000000   1.000  0.010
  9  

                 232-Cooked; Dried; Boiled     300.000000   1.000  0.010
  9  

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  9  

                 242-Cooked; Canned; Boiled    300.000000   1.000  0.010
  9  

                 250-Cooked; Cured etc; Cook Meth N/S

                                               300.000000   1.000  0.010
  9  

                 252-Cooked; Cured etc; Boiled 300.000000   1.000  0.010
  9  

                 253-Cooked; Cured etc; Fried  300.000000   1.000  0.010
  9  

19022741 19B  Pepper, black and white-babyfood

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  9  

14002820 14   Pistachio                        300.000000   1.000  0.020
  2  

12002860 12   Plum, prune, fresh                 2.000000   1.000  1.000
     

12002861 12   Plum, prune, fresh-babyfood        2.000000   1.000  1.000
     

12002870 12   Plum, prune, dried                 2.000000   1.000  1.000
     

12002871 12   Plum, prune, dried-babyfood        2.000000   1.000  1.000
     

12002880 12   Plum, prune, juice                 2.000000   1.000  1.000
     

12002881 12   Plum, prune, juice-babyfood        2.000000   1.000  1.000
     

19013340 19A  Savory

                 110-Uncooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 130-Uncooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 210-Cooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 211-Cooked; Fresh or N/S; Baked

                                                 0.000000   1.000  0.010
     

                 212-Cooked; Fresh or N/S; Boiled

                                                 0.000000   1.000  0.010
     

                 213-Cooked; Fresh or N/S; Fried

                                                 0.000000   1.000  0.010
     

                 215-Cooked; Fresh or N/S; Boiled/baked

                                                 0.000000   1.000  0.010
     

                 221-Cooked; Frozen; Baked     300.000000   1.000  0.010
  1  

                 233-Cooked; Dried; Fried      300.000000   1.000  0.010
  1  

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

95003360 O    Sesame, seed

                 110-Uncooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 210-Cooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 211-Cooked; Fresh or N/S; Baked

                                                 0.000000   1.000  0.010
     

                 212-Cooked; Fresh or N/S; Boiled

                                                 0.000000   1.000  0.010
     

                 213-Cooked; Fresh or N/S; Fried

                                                 0.000000   1.000  0.010
     

                 230-Cooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 231-Cooked; Dried; Baked      300.000000   1.000  0.010
  1  

                 232-Cooked; Dried; Boiled     300.000000   1.000  0.010
  1  

95003361 O    Sesame, seed-babyfood            300.000000   1.000  0.010
  1  

19023540 19B  Spices, other

                 110-Uncooked; Fresh or N/S; Cook Meth N/S

                                                 0.000000   1.000  0.010
     

                 120-Uncooked; Frozen; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 130-Uncooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 150-Uncooked; Cured etc; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 210-Cooked; Fresh or N/S; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 211-Cooked; Fresh or N/S; Baked

                                               300.000000   1.000  0.010
  1  

                 212-Cooked; Fresh or N/S; Boiled

                                               300.000000   1.000  0.010
  1  

                 213-Cooked; Fresh or N/S; Fried

                                               300.000000   1.000  0.010
  1  

                 214-Cooked; Fresh or N/S; Fried/baked

                                               300.000000   1.000  0.010
  1  

                 215-Cooked; Fresh or N/S; Boiled/baked

                                               300.000000   1.000  0.010
  1  

                 221-Cooked; Frozen; Baked     300.000000   1.000  0.010
  1  

                 223-Cooked; Frozen; Fried     300.000000   1.000  0.010
  1  

                 230-Cooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 231-Cooked; Dried; Baked      300.000000   1.000  0.010
  1  

                 232-Cooked; Dried; Boiled     300.000000   1.000  0.010
  1  

                 233-Cooked; Dried; Fried      300.000000   1.000  0.010
  1  

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 242-Cooked; Canned; Boiled    300.000000   1.000  0.010
  1  

                 250-Cooked; Cured etc; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 252-Cooked; Cured etc; Boiled 300.000000   1.000  0.010
  1  

                 253-Cooked; Cured etc; Fried  300.000000   1.000  0.010
  1  

19023541 19B  Spices, other-babyfood

                 211-Cooked; Fresh or N/S; Baked

                                               300.000000   1.000  0.010
  1  

                 230-Cooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.010
  1  

14003910 14   Walnut

                 110-Uncooked; Fresh or N/S; Cook Meth N/S

                                               300.000000   1.000  0.020
  5  

                 130-Uncooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.020
  5  

                 210-Cooked; Fresh or N/S; Cook Meth N/S

                                               300.000000   1.000  0.020
  5  

                 211-Cooked; Fresh or N/S; Baked

                                               300.000000   1.000  0.020
  5  

                 221-Cooked; Frozen; Baked     300.000000   1.000  0.020
  5  

                 230-Cooked; Dried; Cook Meth N/S

                                               300.000000   1.000  0.020
  5  

                 240-Cooked; Canned; Cook Meth N/S

                                               300.000000   1.000  0.020
  5  

Attachment 2 - Acute DEEM Results File

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for PPO                                
(1994-98 data)

Residue file: pchacuteRDFdistribnoguar8-1-07.R98  Adjustment factor #2
NOT used.

Analysis Date: 08-09-2007/10:13:16    Residue file dated:
08-09-2007/09:53:32/8

NOEL (Acute) =  30.000000 mg/kg body-wt/day

Daily totals for food and foodform consumption used.

MC iterations = 1000      MC list in residue file     MC seed = 1128

Run Comment: ""

========================================================================
=======

Summary calculations (per capita):

      95th Percentile             99th Percentile             99.9th
Percentile

 Exposure  % aRfD     MOE    Exposure  % aRfD     MOE    Exposure  %
aRfD     MOE  

---------- ------- -------- ---------- ------- -------- ----------
------- --------

U.S. Population:

  0.000250    0.83  119857    0.001847    6.16   16244    0.010057  
33.52    2982  

All infants:

  0.000060    0.20  500949    0.007504   25.01    3998    0.033002 
110.01     909  

Children 1-2 yrs:

  0.001142    3.81   26274    0.004707   15.69    6373    0.033982 
113.27     882  

Children 3-5 yrs:

  0.000675    2.25   44443    0.003306   11.02    9075    0.020321  
67.74    1476  

Children 6-12 yrs:

  0.000328    1.09   91506    0.001688    5.63   17767    0.011826  
39.42    2536  

Youth 13-19 yrs:

  0.000155    0.52  194171    0.001071    3.57   28011    0.007221  
24.07    4154  

Adults 20-49 yrs:

  0.000178    0.59  168874    0.001086    3.62   27618    0.008080  
26.93    3712  

Adults 50+ yrs:

  0.000336    1.12   89371    0.002643    8.81   11348    0.010392  
34.64    2886  

Females 13-49 yrs:

  0.000188    0.63  159475    0.001082    3.61   27715    0.008309  
27.70    3610  

                                      9 

Attachment 3. DEEM RDF File

RDF#1

spice/herb (1% CT)

TOTALZ=1584

TOTALNZ=16

38.8

31.2

215

168

200

112

192

384

126

192

1080

627

384

359

124

62.5

RDF#2

Nutmeat 2%CT

Nutmeats (2% CT)

TOTALZ=245

TOTALNZ=5

3.04

4.88

8.22

7.42

7.79

RDF#3

Cocoa (1.3% CT)

TOTALZ=229

TOTALNZ=3

4.93

6.16

4.68

	RDF#4

Almonds (2% CT)

TOTALZ=98

TOTALNZ=2

3.04

4.88

RDF#5

Walnut (2% CT)

TOTALZ=95

TOTALNZ=2

7.42

7.79

RDF#6

Basil (1% CT)

TOTALZ=396

TOTALNZ=4

1080

627

384

359

RDF#7

Onion (1% CT)

TOTALZ=198

TOTALNZ=2

38.8

31.2

RDF#8

Garlic (1% CT)

TOTALZ=396

TOTALNZ=4

192

384

126

192

	RDF#9

Black Pepper (1% CT)

TOTALZ=396

TOTALNZ=4

215

168

200

112

RDF#10

Pecan (2% CT)

TOTALZ=98

TOTALNZ=2

8.2

8.0



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