Document ID: EPA-HQ-OPP-2006-0333-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2006-08-28T04:00Z

Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
1
of
20
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
MEMORANDUM
DATE:
31­
MAY­
2006
SUBJECT:
Kresoxim­
methyl:
Chronic
and
Cancer
Aggregate
Dietary
(
Food
and
Drinking
Water)
Exposure
and
Risk
Assessments
for
the
Proposed
Section
3
Registration
on
Cucurbit
Vegetables.
PP#
3E6594.

PC
Code:
129111
Decision
Number:
354442
DP
Number:
329370
REVIEWER:
Susan
L.
Stanton,
Environmental
Scientist
Reregistration
Branch
3
Health
Effects
Division
(
7509P)

THROUGH:
Thomas
Bloem,
Chemist
David
Hrdy,
Biologist
Dietary
Exposure
Science
Advisory
Council
(
DESAC)
Health
Effects
Division
(
7509P)

and
P.
V.
Shah,
Branch
Senior
Scientist
Registration
Action
Branch
1
Health
Effects
Division
(
7509P)

TO:
George
F.
Kramer,
Ph.
D.,
Chemist
Registration
Action
Branch
1
Health
Effects
Division
(
7509P)

and
Barbara
Madden/
Daniel
Rosenblatt,
RM
05
Minor
Use,
Inerts
&
Emergency
Response
Branch
Registration
Division
(
7505P)
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
2
of
20
Executive
Summary
A
chronic/
cancer
dietary
risk
assessment
was
conducted
using
the
Dietary
Exposure
Evaluation
Model
(
DEEM­
FCID
 
)
,
Version
2.03,
which
uses
food
consumption
data
from
the
U.
S.
Department
of
Agriculture's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII)
from
1994­
1996
and
1998.
The
analysis
was
performed
to
support
a
FIFRA
section
3
registration
request
from
the
Interregional
Research
Project
No.
4
(
IR­
4)
for
the
fungicide,
kresoxim­
methyl,
on
cucurbit
vegetables.

The
partially
refined,
tier
3
chronic/
cancer
analysis
incorporated
average
field
trial
residues
for
pome
fruits,
grapes,
pecans
and
cucurbit
vegetables.
Exposure
estimates
were
further
refined
based
on
available
processing
data
for
grapes
and
apples
and
screening­
level
percent
crop
treated
(%
CT)
data
for
many
of
the
registered
commodities.
Exposure
estimates
for
cucurbit
vegetables
(
the
new
use)
were
not
adjusted
for
%
CT.

Drinking
water
exposure
was
assessed
directly
in
the
DEEM
analysis
using
estimated
drinking
water
concentrations
(
EDWCs)
of
kresoxim­
methyl
and
its
BF
490­
1
metabolite
in
surface
water
that
were
generated
by
the
PRZM­
EXAMS
model.
For
the
chronic
exposure
assessment,
the
1­
in­
10
year
annual
mean
value
of
29.32
ppb
was
used;
for
the
cancer
assessment,
the
30­
year
mean
value
of
18.76
ppb
was
used.

Chronic,
Non­
Cancer
Dietary
Exposure
Results
Chronic
combined
dietary
exposure
estimates
for
food
and
drinking
water
are
well
below
HED's
level
of
concern
for
non­
cancer
effects
(
i.
e.,
<
100%
of
the
cPAD
of
0.36
mg/
kg
bw/
day)
for
the
overall
U.
S.
population
and
all
population
subgroups.
Using
the
DEEM­
FCID
software,
chronic
dietary
exposure
is
estimated
at
0.000686
mg/
kg/
day
(
0.2%
of
the
cPAD)
for
the
U.
S.
population
and
0.002135
mg/
kg/
day
(
0.6%
of
the
cPAD)
for
infants
less
than
1
year
old,
the
population
subgroup
with
the
highest
estimated
chronic
dietary
exposure
to
kresoxim­
methyl.

Chronic,
Cancer
Dietary
Exposure
Results
HED
is
generally
concerned
when
estimated
cancer
risk
exceeds
one
in
one
million
(
i.
e.,
10­
6).
For
kresoxim­
methyl,
estimated
exposure
from
food
and
drinking
water
results
in
a
lifetime
cancer
risk
of
1.3
x
10­
6.
HED
considers
cancer
risk
estimates
between
1
x
10­
6
and
3
x
10­
6
to
fall
within
the
acceptable
range
of
cancer
risk
(
i.
e.,
less
than
10­
6);
therefore,
the
cancer
risk
estimate
for
kresoxim­
methyl
is
below
HED's
level
of
concern.

Although
the
estimated
cancer
risk
is
at
the
upper
end
of
the
acceptable
range,
actual
cancer
risk
is
likely
significantly
lower.
Drinking
water
exposure
accounts
for
87%
of
the
estimated
risk.
Drinking
water
exposure
estimates
are
based
on
screening
level
PRZM­
EXAMS
modeling
results
which
are
designed
to
provide
conservative,
health­
protective
exposure
estimates.
Actual
drinking
water
exposures
are
likely
to
be
lower
than
the
modeled
estimates.
The
other
significant
contributor
(
11%)
to
estimated
cancer
risk
is
cucurbit
vegetables,
the
proposed
new
use.
As
noted
above,
residue
estimates
for
cucurbits
were
not
adjusted
to
account
for
the
percent
of
the
crop
treated
with
kresoxim­
methyl
(
i.
e.,
100%
CT
was
assumed).
Together,
drinking
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
3
of
20
water
and
cucurbits
account
for
98%
of
the
estimated
cancer
risk.
Refinements
in
these
components
would
result
in
lower
estimated
cancer
risk.

I.
Introduction
Dietary
risk
assessment
incorporates
both
exposure
and
toxicity
of
a
given
pesticide.
For
noncancer
chronic
assessments,
the
risk
is
expressed
as
a
percentage
of
a
maximum
acceptable
dose
(
i.
e.,
the
dose
which
HED
has
concluded
will
result
in
no
unreasonable
adverse
health
effects).
This
dose
is
referred
to
as
the
population
adjusted
dose
(
PAD).
The
PAD
is
equivalent
to
the
reference
dose
(
RfD)
divided
by
the
special
Food
Quality
Protection
Act
(
FQPA)
Safety
Factor.

For
non­
cancer
chronic
exposures,
HED
is
concerned
when
estimated
dietary
risk
exceeds
100%
of
the
PAD.
HED
is
generally
concerned
when
estimated
cancer
risk
exceeds
one
in
one
million
(
i.
e.,
the
risk
exceeds
1
x
10­
6).
References
which
discuss
the
chronic
risk
assessments
in
more
detail
are
available
on
the
EPA/
pesticides
web
site:
"
Available
Information
on
Assessing
Exposure
from
Pesticides,
A
User's
Guide,"
6/
21/
2000,
web
link:
http://
www.
epa.
gov/
fedrgstr/
EPA­
PEST/
2000/
July/
Day­
12/
6061.
pdf
;
or
see
SOP
99.6
(
8/
20/
99).

The
most
recent
HED
dietary
risk
assessment
for
kresoxim­
methyl
was
conducted
by
Tom
Bloem
(
10/
21/
99,
DP260302)
to
support
the
first
FIFRA
§
3
food
uses
on
pome
fruit,
grapes
and
pecans.

II.
Food
Residue
Information
Residues
of
Concern:

The
nature
of
the
residue
in
pome
fruits,
grapes,
and
wheat
is
adequately
understood,
and
those
results
may
be
translated
to
cucurbit
vegetables.
The
residues
of
concern
for
tolerance
and
risk
assessment
purposes
include
kresoxim
methyl,
BF
490­
1,
BF
490­
2
(
free
and
glucose
conjugated)
and
BF
490­
9
(
free
and
glucose
conjugated)
(
DP#
254643,
T.
Bloem,
5­
Apr­
1999).

The
MARC
determined
that
the
only
residue
of
concern
in
ruminant
tissues
for
tolerance
and
risk
assessment
purposes
is
the
metabolite,
BF
490­
1(
DP#
254643,
T.
Bloem,
5­
Apr­
1999).

Tolerances:

Tolerances
are
established
under
40
CFR
§
180.554(
a)
for
the
combined
residues
of
kresoximmethyl
and
its
metabolites
in
or
on
apple
pomace
(
1.0
ppm),
pome
fruit
(
0.5
ppm),
grape
(
1.0
ppm),
raisin
(
1.5
ppm)
and
pecans
(
0.15
ppm).
Based
on
the
review
of
additional
field
trial
data
for
grape,
HED
recommended
that
the
grape
tolerance
be
raised
to
1.2
ppm
(
T.
Bloem;
10/
21/
99;
DP#
260302);
however,
to
date,
the
tolerance
has
not
been
raised.

Tolerances
are
established
under
40
CFR
§
180.554(
b)
for
residues
of
the
metabolite,
BF
490­
1,
in
or
on
ruminant
meat
by­
products
at
0.01
ppm.
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
4
of
20
IR­
4
has
proposed
new
tolerances
for
the
combined
residues
of
kresoxim­
methyl
and
its
metabolites
in
or
on
cucurbit
vegetables
at
0.5
ppm.
HED
has
reviewed
residue
data
submitted
to
support
the
crop
group
tolerance
and
concluded
that
the
following
tolerance
is
appropriate,
pending
resolution
of
certain
petition
deficiencies
[
George
Kramer;
05/
26/
2006;
DP#
328725].

Vegetable,
cucurbit
(
group
9)....................................
0.35
ppm
Residue
Data
used
for
the
Acute
and
Chronic
Assessments:

The
chronic/
cancer
dietary
exposure
analysis
incorporated
combined
average
field
trial
residues
of
kresoxim­
methyl
and
its
metabolites
of
concern
for
pome
fruits,
grapes,
pecans
(
T.
Bloem;
4/
16/
99;
DP#
255317
and
T.
Bloem;
10/
21/
99;
DP#
260302)
and
cucurbit
vegetables
(
George
Kramer;
05/
26/
2006;
DP#
328725).
In
calculating
average
field
trial
residues,
residues
less
than
the
limit
of
quantification
(
0.05
ppm)
were
assigned
a
value
of
½
LOQ
(
0.025
ppm).
The
average
apple
field
trial
residue
was
used
to
compute
an
anticipated
cattle
dietary
burden,
which
was
used
to
calculate
an
anticipated
residue
in
meat
byproducts
(
T.
Bloem;
04/
16/
99;
DP#
255318).
Anticipated
residues
for
apples,
grapes,
pears
and
pecans
were
further
refined
based
on
screening
level
percent
crop
treated
(%
CT)
data
provided
by
BEAD
[
Kresoxim­
methyl
Screening­
level
Usage
Analysis
(
SLUA);
04/
17/
2006].
100%
of
all
other
crops
(
including
cucurbit
vegetables)
were
assumed
to
be
treated
with
kresoxim­
methyl.

Based
on
the
submitted
apple
and
grape
processing
studies,
concentration
factors
for
grape
juice,
raisins
and
apple
juice/
cider
were
reduced
to
0.7,
1.4
and
0.2,
respectively.
Default
concentration
factors
were
used
for
all
other
commodities.
The
residue
data
used
in
the
chronic
dietary
analyses
are
summarized
below
in
Table
1.

Table
1.
Residue
Data
Used
in
the
Chronic/
Cancer
Dietary
Analyses
RAC
Data
Source
Ave.
%
CT
Processing
Factors
Anticipated
Residue
Apple
Ave.
FT
10
0.2
(
juice)

8
(
dried)
0.1094
Pears
(
translated
to
crabapples,
loquats,
quinces)
Ave.
FT
Pear
­
5
Others
­
100
6.25
(
dried)
0.1245
Grapes
Ave.
FT
5
0.7
(
juice)

1.4
(
raisins)
0.4259
Pecans
Ave.
FT
<
1
N/
A
0.075
Cucumber
(
translated
to
balsam
pear,
Chinese
waxgourd)
Ave.
FT
100
N/
A
0.087
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
5
of
20
Table
1.
Residue
Data
Used
in
the
Chronic/
Cancer
Dietary
Analyses
RAC
Data
Source
Ave.
%
CT
Processing
Factors
Anticipated
Residue
Cantaloupe
(
translated
to
casaba,
honeydew,
watermelon)
Ave.
FT
100
N/
A
0.151
Summer
squash
(
translated
to
chayote,
pumpkin,
winter
squash)
Ave.
FT
100
N/
A
0.116
Cattle,
goat
and
sheep
meat
byproducts,
except
liver
0.00152
Cattle,
goat
and
sheep
liver
Calculated
based
on
anticipated
cattle
dietary
burden
N/
A
N/
A
0.00029
III.
Drinking
Water
Data
The
drinking
water
residues
used
in
the
dietary
risk
assessment
were
provided
by
the
Environmental
Fate
and
Effects
Division
(
EFED)
(
Cheryl
A.
Sutton,
DP#
326550;
05/
22/
2006).
The
residues
were
incorporated
directly
into
this
dietary
assessment
under
the
DEEM­
FCID
food
categories
"
water,
direct,
all
sources"
and
"
water,
indirect,
all
sources."

The
residues
of
concern
in
drinking
water
are
kresoxim­
methyl
and
its
major
acid
degradate/
metabolite,
BF
490­
1.
Based
on
the
environmental
fate
properties
of
kresoximmethyl
EFED
believes
that
the
parent
compound
is
relatively
short­
lived
and,
therefore,
unlikely
to
leach
to
ground
water
or
move
offsite
to
surface
water
in
significant
concentrations.
However,
BF
490­
1
has
the
physical/
chemical
characteristics
of
pesticides
that
are
known
to
leach
to
ground
water
or
to
move
offsite
to
surface
water
and
may
pose
a
risk
of
ground
or
surface
water
contamination,
particularly
when
kresoxim­
methyl
is
applied
to
fields
with
one
or
more
of
the
following
characteristics:
alkaline
soils,
low
organic
matter,
high
sand
content,
shallow
groundwater
table
or
nearby
bodies
of
water.

There
are
no
drinking
water
monitoring
data
available
for
kresoxim­
methyl
or
its
metabolite.
Estimated
ground
water
and
surface
water
concentrations
were
generated
using
the
SCI­
GROW
and
PRZM­
EXAMS
models,
respectively.
Estimated
environmental
concentrations
(
EECs)
were
provided
for
both
kresoxim­
methyl
and
BF
490­
1.
The
PRZM­
EXAMS
surface
water
modeling
estimates
were
based
on
a
Florida
cucurbits
crop
scenario.
The
modeled
EECs
for
ground
and
surface
water
are
summarized
in
Table
2.
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
6
of
20
Table
2.
Estimated
Ground
and
Surface
Water
Concentrations
of
Kresoxim­
methyl
and
BF
490­
1
Surface
Water
Ground
Water
Concentration
(
ppb)
1
in
10
year
Annual
Mean
Concentration
(
ppb)
30­
Year
Mean
Concentration
(
ppb)
Kresoxim­
methyl
0.000257
0.12
0.06
BF
490­
1
4.2
29.2
18.7
Combined
Residues
of
Concern
4.2
29.32
18.76
Since
the
surface
water
EECs
are
higher
than
the
groundwater
EEC,
HED
selected
these
values
for
use
in
the
dietary
assessment.
In
accordance
with
HED
policy,
the
1­
in­
10
year
mean
of
29.32
ppb
was
used
for
the
chronic
(
non­
cancer)
analysis,
and
the
30­
year
mean
of
18.76
ppb
was
used
for
the
cancer
analysis.

IV.
DEEM­
FCID
 
Program
and
Consumption
Information
Kresoxim­
methyl
chronic/
cancer
dietary
exposure
assessments
were
conducted
using
the
Dietary
Exposure
Evaluation
Model
software
with
the
Food
Commodity
Intake
Database
(
DEEMFCID
 
,
Version
2.03),
which
incorporates
consumption
data
from
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII),
1994­
1996
and
1998.
The
1994­
96,
98
data
are
based
on
the
reported
consumption
of
more
than
20,000
individuals
over
two
non­
consecutive
survey
days.
Foods
"
as
consumed"
(
e.
g.,
apple
pie)
are
linked
to
EPA­
defined
food
commodities
(
e.
g.
apples,
peeled
fruit
­
cooked;
fresh
or
N/
S;
baked;
or
wheat
flour
­
cooked;
fresh
or
N/
S,
baked)
using
publicly
available
recipe
translation
files
developed
jointly
by
USDA/
ARS
and
EPA.
For
chronic
exposure
assessment,
consumption
data
are
averaged
for
the
entire
U.
S.
population
and
within
population
subgroups,
but
for
acute
exposure
assessment
are
retained
as
individual
consumption
events.
Based
on
analysis
of
the
1994­
96,
98
CSFII
consumption
data,
which
took
into
account
dietary
patterns
and
survey
respondents,
HED
concluded
that
it
is
most
appropriate
to
report
risk
for
the
following
population
subgroups:
the
general
U.
S.
population,
all
infants
(<
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
adults
20­
49,
females
13­
49,
and
adults
50+
years
old.

For
chronic
dietary
exposure
assessments,
an
estimate
of
the
residue
level
in
each
food
or
foodform
(
e.
g.,
orange
or
orange
juice)
on
the
food
commodity
residue
list
is
multiplied
by
the
average
daily
consumption
estimate
for
that
food/
food
form
to
produce
a
residue
intake
estimate.
The
resulting
residue
intake
estimate
for
each
food/
food
form
is
summed
with
the
residue
intake
estimates
for
all
other
food/
food
forms
on
the
commodity
residue
list
to
arrive
at
the
total
average
estimated
exposure.
Exposure
is
expressed
in
mg/
kg
body
weight/
day
and
as
a
percent
of
the
cPAD.
This
procedure
is
performed
for
each
population
subgroup.

V.
Toxicological
Information
Based
on
toxicological
considerations
and
the
completeness
of
the
kresoxim­
methyl
database
(
chemistry,
environmental
fate,
and
toxicology),
the
FQPA
Safety
Factor
may
be
reduced
to
1X;
therefore,
the
PAD
is
identical
to
the
RfD.
HEDs
level
of
concern
is
for
chronic
exposures
greater
than
100%
of
the
PAD
or
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
7
of
20
lifetime
cancer
risks
greater
than
1
x
10­
6.
A
summary
of
the
toxicological
doses
and
endpoints
selected
for
dietary
exposure
assessment
is
provided
in
Table
3.

Table
3.
Summary
of
Toxicological
Dose
and
Endpoints
for
Kresoxim­
methyl
for
Use
in
Human
Health
Risk
Assessment1.

Exposure
Scenario
Dose
Used
in
Risk
Assessment,
UF
Hazard
and
Exposure
Based
Special
FQPA
Safety
Factor
Study
and
Toxicological
Effects
Acute
Dietary
Not
applicable.
An
endpoint
attributable
to
a
single
exposure
was
not
identified
for
the
U.
S.
population
or
any
population
subgroup.

Chronic
Dietary
all
populations
NOAEL=
36
mg/
kg/
d
UF
=
100
Chronic
RfD
=
0.36
mg/
kg/
d
FQPA
SF
=
1X
cPAD
=
chr
RfD
FQPA
SF
=
0.36
mg/
kg/
day
Combined
Oral
Chronic
Toxicity/
Carcinogenicity
Study
 
Rat.
LOAEL
=
375/
497
mg/
kg/
day
in
males/
females,
based
on
decreased
body
weights
and
body
weight
gains
and
increased
gross
and
microscopic
liver
and
biliary
lesions,
and
(
in
females)
increased
incidences
of
liver
masses
(
HIARC
Meeting,
2­
Feb­
1999).

Cancer
(
oral,
dermal,
inhalation)
Kresoxim­
methyl
has
been
classified
as
a
probable
human
carcinogen
by
the
Cancer
Peer
Review
Committee
and
Science
Advisory
Panel
(
CARC
Meeting,
17­
Mar­
1999).
The
Q1*
for
kresoximmethyl
is
0.0029
(
mg/
kg/
day)­
1
(
3/
4
scaling
factor;
Memo,
L.
Brunsman,
20­
May­
1999)

1UF
=
uncertainty
factor,
FQPA
SF
=
Special
FQPA
safety
factor,
NOAEL
=
no
observed
adverse
effect
level,
LOAEL
=
lowest
observed
adverse
effect
level,
cPAD
=
chronic
population
adjusted
dose,
RfD
=
reference
dose.

VI.
Results/
Discussion
As
stated
above,
for
chronic
assessments,
HED
is
concerned
when
dietary
risk
exceeds
100%
of
the
cPAD.
The
DEEM­
FCID
 
analyses
estimate
the
dietary
exposure
of
the
U.
S.
population
and
various
population
subgroups.
The
chronic
results
reported
in
Table
4
are
for
the
general
U.
S.
Population,
all
infants
(<
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
females
13­
49,
adults
20­
49,
and
adults
50+
years.
Cancer
risk
is
estimated
for
the
overall
U.
S.
population
only,
in
accordance
with
Agency
policy.

Results
of
Chronic
Dietary
Exposure
Analysis
Kresoxim­
methyl
chronic
dietary
(
food
+
water)
exposure
estimates
using
the
DEEM­
FCID
 
software
are
well
below
HED's
level
of
concern
for
the
U.
S.
population
and
each
of
the
population
subgroups.
Dietary
exposure
was
estimated
at
0.000686
mg/
kg/
day
for
the
U.
S.
population
(
0.2%
of
the
cPAD)
and
0.002135
mg/
kg/
day
(
0.6%
of
the
cPAD)
for
the
most
highly
exposed
population
subgroup
(
infants,
<
1
year
old).
The
estimated
exposures/
risks
from
food
and
drinking
water
are
summarized
in
Table
4
for
all
populations.
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
8
of
20
Table
4.
Summary
of
Chronic
Dietary
(
Food
+
Drinking
Water)
Exposure
and
Risk
for
Kresoxim­
methyl1
cPAD
(
mg/
kg/
day)
Exposure
(
mg/
kg/
day)
%
cPAD
General
U.
S.
Population
0.000686
0.2
All
Infants
(<
1
year
old)
0.002135
0.6
Children
1­
2
years
old
0.001102
0.3
Children
3­
5
years
old
0.001030
0.3
Children
6­
12
years
old
0.000687
0.2
Youth
13­
19
years
old
0.000495
0.1
Adults
20­
49
years
old
0.000623
0.2
Adults
50+
years
old
0.000675
0.2
Females
13­
49
years
old
0.36
0.000627
0.2
1The
population
subgroup
with
the
highest
estimated
chronic
dietary
(
food
+
drinking
water)
exposure
and
risk
is
indicated
by
bold
text.

Results
of
Cancer
Dietary
Exposure
Analysis
The
estimated
exposure
of
the
general
U.
S.
population
to
kresoxim­
methyl
is
0.000464
mg/
kg/
day.
Applying
the
Q1*
of
0.0029
(
mg/
kg/
day)­
1
to
the
exposure
value
results
in
a
lifetime
cancer
risk
estimate
of
1.3
x
10­
6.
HED
considers
cancer
risk
estimates
between
1
x
10­
6
and
3
x
10­
6
to
fall
within
the
acceptable
range
of
cancer
risk
(
i.
e.,
less
than
10­
6);
therefore,
the
cancer
risk
estimate
for
kresoxim­
methyl
is
below
HED's
level
of
concern.

VII.
Characterization
of
Inputs/
Outputs
The
chronic/
cancer
assessment
for
kresoxim­
methyl
is
a
partially
refined,
tier
3
assessment
which
incorporates
average
field
trial
residues
for
all
food
commodities,
available
processing
data
for
grapes
and
apples
and
screening­
level
percent
crop
treated
(%
CT)
data
for
most
of
the
registered
commodities.
Based
on
these
refinements,
chronic,
non­
cancer
exposures
to
kresoxim­
methyl
are
estimated
to
be
well
below
HED's
level
of
concern.
The
estimated
kresoxim­
methyl
cancer
risk
is
1.3
x
10­
6.
Although
the
cancer
risk
is
at
the
upper
end
of
the
acceptable
range,
actual
cancer
risk
is
likely
significantly
lower.
Drinking
water
exposure
accounts
for
87%
of
the
estimated
risk.
Since
there
are
no
water
monitoring
data
available
for
kresoxim­
methyl,
drinking
water
exposure
estimates
were
based
on
screening
level
PRZMEXAMS
surface
water
modeling
results.
The
drinking
water
inputs
may
be
considered
conservative
for
the
following
reasons.
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
9
of
20
·
The
model
results
assume
that
applications
will
be
made
at
maximum
application
rates
every
year
for
30
years.

·
The
PRZM­
EXAMS
models
are
based
on
an
actual
reservoir/
watershed
system
in
Illinois
which
is
known
to
be
a
highly
vulnerable
configuration.

Based
on
these
considerations,
it
is
likely
that
actual
exposure
to
kresoxim­
methyl
from
drinking
water
is
somewhat
lower
than
the
estimates
provided
in
this
assessment.
However,
without
water
monitoring
data,
further
refinement
of
exposure
estimates
is
not
possible.

The
other
significant
contributor
(
11%)
to
estimated
cancer
risk
is
cucurbit
vegetables,
the
proposed
new
use.
As
noted
in
section
II
(
Food
Residue
Information),
residue
estimates
for
cucurbits
were
not
adjusted
to
account
for
the
percent
of
the
crop
treated
with
kresoxim­
methyl
(
i.
e.,
100%
CT
was
assumed).
Therefore,
the
exposure
estimates
for
these
crops
likely
overstate
actual
chronic
exposures.

Together,
drinking
water
and
cucurbits
account
for
98%
of
the
estimated
cancer
risk.
Further
refinements
in
these
components
would
result
in
lower
estimated
cancer
risk.

VIII.
Conclusions
A
partially
refined,
Tier
3
chronic/
cancer
dietary
risk
assessment
was
conducted
using
the
Dietary
Exposure
Evaluation
Model
(
DEEM­
FCID
 
)
,
Version
2.03.
The
analysis
incorporated
average
field
trial
residues
for
all
food
commodities,
available
processing
data
for
grapes
and
apples
and
screening­
level
percent
crop
treated
(%
CT)
data
for
most
of
the
registered
commodities.
Screening
level
PRZM­
EXAMS
model
results
were
used
to
estimate
drinking
water
exposures
to
kresoxim­
methyl.
The
resulting
chronic,
non­
cancer
dietary
risk
estimates
are
well
below
HED's
level
of
concern
for
the
U.
S.
population
and
all
population
subgroups.
Estimated
cancer
risk
is
also
below
HED's
level
of
concern
for
the
U.
S.
population.

IX.
List
of
Attachments
Chronic
Food
+
Drinking
Water
Input
File
Chronic
Food
+
Drinking
Water
Results
File
Cancer
Food
+
Drinking
Water
Input
File
Cancer
Food
+
Drinking
Water
Results
File
(
w/
Commodity
Contribution
Report
Attached)
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
10
of
20
Chronic
Food
+
Drinking
Water
Input
File
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
KRESOXIM­
METHYL
1994­
98
data
Residue
file:
C:\
Documents
and
Settings\
sstanton\
My
Documents\
DEEM­
FCID
Files\
Kresoxim
methyl\
Kresoxim
methyl
Chronic
food
+
water.
R98
Adjust.
#
2
NOT
used
Analysis
Date
05­
25­
2006
Residue
file
dated:
05­
24­
2006/
09:
10:
19/
8
Reference
dose
(
RfD)
=
0.36
mg/
kg
bw/
day
Comment:
Chronic
Assessment
including
proposed
use
on
cucurbit
vegetables
group
9
and
drinking
water.
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Food
Crop
Residue
Adj.
Factors
Comment
EPA
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
11000070
11
Apple,
fruit
with
peel
0.109400
1.000
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
11000080
11
Apple,
peeled
fruit
0.109400
1.000
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
11000081
11
Apple,
peeled
fruit­
babyfood
0.109400
1.000
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
11000090
11
Apple,
dried
0.109400
8.000
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
11000091
11
Apple,
dried­
babyfood
0.109400
8.000
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
11000100
11
Apple,
juice
0.109400
0.200
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
11000101
11
Apple,
juice­
babyfood
0.109400
0.200
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
11000110
11
Apple,
sauce
0.109400
1.000
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
11000111
11
Apple,
sauce­
babyfood
0.109400
1.000
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
09020210
9B
Balsam
pear
0.087000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Cucumber
(
PP#
3E6594)
21000460
M
Beef,
meat
byproducts
0.001520
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
21000461
M
Beef,
meat
byproducts­
babyfood
0.001520
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
21000480
M
Beef,
kidney
0.001520
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
21000490
M
Beef,
liver
0.000290
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
21000491
M
Beef,
liver­
babyfood
0.000290
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
09010750
9A
Cantaloupe
0.151000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
(
PP#
3E6594)
09010800
9A
Casaba
0.151000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Cantaloupe
(
PP#
3E6594)
09020880
9B
Chayote,
fruit
0.116000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Summer
Squash
(
PP#
3E6594)
09021020
9B
Chinese
waxgourd
0.087000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Cucumber
(
PP#
3E6594)
11001290
11
Crabapple
0.124500
1.000
1.000
Ave
FT
Full
comment:
Ave
FT
(
MRID
44539711)
09021350
9B
Cucumber
0.087000
1.000
1.000
Ave.
F
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
11
of
20
Full
comment:
Ave.
FT
(
PP#
3E6594)
23001700
M
Goat,
meat
byproducts
0.001520
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
23001720
M
Goat,
kidney
0.001520
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
23001730
M
Goat,
liver
0.000290
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
95001750
O
Grape
0.425900
1.000
0.050
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44341069/
44889301)
95001760
O
Grape,
juice
0.425900
0.700
0.050
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44341069/
44889301)
95001761
O
Grape,
juice­
babyfood
0.425900
0.700
0.050
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44341069/
44889301)
95001770
O
Grape,
leaves
0.425900
1.000
0.050
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44341069/
44889301)
95001780
O
Grape,
raisin
0.425900
1.400
0.050
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44341069/
44889301)
95001790
O
Grape,
wine
and
sherry
0.425900
1.000
0.050
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44341069/
44889301)
09011870
9A
Honeydew
melon
0.151000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Cantaloupe
(
PP#
3E6594)
11002100
11
Loquat
0.124500
1.000
1.000
Ave
FT
Full
comment:
Ave
FT
(
MRID
44539711)
11002660
11
Pear
0.124500
1.000
0.050
Ave
FT
Full
comment:
Ave
FT
(
MRID
44539711)
11002661
11
Pear­
babyfood
0.124500
1.000
0.050
Ave
FT
Full
comment:
Ave
FT
(
MRID
44539711)
11002670
11
Pear,
dried
0.124500
6.250
0.050
Ave
FT
Full
comment:
Ave
FT
(
MRID
44539711)
11002680
11
Pear,
juice
0.124500
1.000
0.050
Ave
FT
Full
comment:
Ave
FT
(
MRID
44539711)
11002681
11
Pear,
juice­
babyfood
0.124500
1.000
0.050
Ave
FT
Full
comment:
Ave
FT
(
MRID
44539711)
14002690
14
Pecan
0.075000
1.000
0.010
Ave
FT
Full
comment:
Ave
FT
(
MRID
44341071)
09023080
9B
Pumpkin
0.116000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Summer
Squash
(
PP#
3E6594)
09023090
9B
Pumpkin,
seed
0.116000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Summer
Squash
(
PP#
3E6594)
11003100
11
Quince
0.124500
1.000
1.000
Ave
FT
Full
comment:
Ave
FT
(
MRID
44539711)
26003400
M
Sheep,
meat
byproducts
0.001520
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
26003420
M
Sheep,
kidney
0.001520
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
26003430
M
Sheep,
liver
0.000290
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
09023560
9B
Squash,
summer
0.116000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
(
PP#
3E6594)
09023561
9B
Squash,
summer­
babyfood
0.116000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
(
PP#
3E6594)
09023570
9B
Squash,
winter
0.116000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Summer
Squash
(
PP#
3E6594)
09023571
9B
Squash,
winter­
babyfood
0.116000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Summer
Squash
(
PP#
3E6594)
86010000
O
Water,
direct,
all
sources
0.029320
1.000
1.000
PRZM­
E
Full
comment:
PRZM­
EXAMS
(
EFED
D245120)
86020000
O
Water,
indirect,
all
sources
0.029320
1.000
1.000
PRZM­
E
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
12
of
20
Full
comment:
PRZM­
EXAMS
(
EFED
D245120)
09013990
9A
Watermelon
0.151000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Cantaloupe
(
PP#
3E6594)
09014000
9A
Watermelon,
juice
0.151000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Cantaloupe
(
PP#
3E6594)
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
13
of
20
Chronic
Food
+
Drinking
Water
Results
File
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
KRESOXIM­
METHYL
(
1994­
98
data)
Residue
file
name:
C:\
Documents
and
Settings\
sstanton\
My
Documents\
DEEM­
FCID
Files\
Kresoxim
methyl\
Kresoxim
methyl
Chronic
food
+
water.
R98
Adjustment
factor
#
2
used.
Analysis
Date
05­
24­
2006/
09:
13:
04
Residue
file
dated:
05­
24­
2006/
09:
10:
19/
8
Reference
dose
(
RfD,
Chronic)
=
.36
mg/
kg
bw/
day
COMMENT
1:
Chronic
Assessment
including
proposed
use
on
cucurbit
vegetables
group
9
and
drinking
water.
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.000686
0.2%

U.
S.
Population
(
spring
season)
0.000687
0.2%
U.
S.
Population
(
summer
season)
0.000784
0.2%
U.
S.
Population
(
autumn
season)
0.000640
0.2%
U.
S.
Population
(
winter
season)
0.000632
0.2%

Northeast
region
0.000640
0.2%
Midwest
region
0.000690
0.2%
Southern
region
0.000643
0.2%
Western
region
0.000793
0.2%

Hispanics
0.000774
0.2%
Non­
hispanic
whites
0.000670
0.2%
Non­
hispanic
blacks
0.000636
0.2%
Non­
hisp/
non­
white/
non­
black
0.000885
0.2%

All
infants
(<
1
year)
0.002135
0.6%
Nursing
infants
0.000836
0.2%
Non­
nursing
infants
0.002628
0.7%
Children
1­
6
yrs
0.001032
0.3%
Children
7­
12
yrs
0.000650
0.2%

Females
13­
19
(
not
preg
or
nursing)
0.000478
0.1%
Females
20+
(
not
preg
or
nursing)
0.000677
0.2%
Females
13­
50
yrs
0.000655
0.2%
Females
13+
(
preg/
not
nursing)
0.000647
0.2%
Females
13+
(
nursing)
0.000973
0.3%

Males
13­
19
yrs
0.000509
0.1%
Males
20+
yrs
0.000600
0.2%
Seniors
55+
0.000679
0.2%

Children
1­
2
yrs
0.001102
0.3%
Children
3­
5
yrs
0.001030
0.3%
Children
6­
12
yrs
0.000687
0.2%
Youth
13­
19
yrs
0.000495
0.1%
Adults
20­
49
yrs
0.000623
0.2%
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
14
of
20
Adults
50+
yrs
0.000675
0.2%
Females
13­
49
yrs
0.000627
0.2%

­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
15
of
20
Cancer
Food
+
Drinking
Water
Input
File
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
KRESOXIM­
METHYL
1994­
98
data
Residue
file:
C:\
Documents
and
Settings\
sstanton\
My
Documents\
DEEM­
FCID
Files\
Kresoxim
methyl\
Kresoxim
methyl
Cancer
food
+
water.
R98
Adjust.
#
2
NOT
used
Analysis
Date
05­
25­
2006
Residue
file
dated:
05­
24­
2006/
09:
08:
45/
8
Q*
=
0.0029
Comment:
Cancer
Assessment
including
proposed
use
on
cucurbit
vegetables
group
9
and
drinking
water.
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Food
Crop
Residue
Adj.
Factors
Comment
EPA
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
11000070
11
Apple,
fruit
with
peel
0.109400
1.000
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
11000080
11
Apple,
peeled
fruit
0.109400
1.000
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
11000081
11
Apple,
peeled
fruit­
babyfood
0.109400
1.000
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
11000090
11
Apple,
dried
0.109400
8.000
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
11000091
11
Apple,
dried­
babyfood
0.109400
8.000
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
11000100
11
Apple,
juice
0.109400
0.200
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
11000101
11
Apple,
juice­
babyfood
0.109400
0.200
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
11000110
11
Apple,
sauce
0.109400
1.000
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
11000111
11
Apple,
sauce­
babyfood
0.109400
1.000
0.100
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44539708)
09020210
9B
Balsam
pear
0.087000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Cucumber
(
PP#
3E6594)
21000460
M
Beef,
meat
byproducts
0.001520
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
21000461
M
Beef,
meat
byproducts­
babyfood
0.001520
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
21000480
M
Beef,
kidney
0.001520
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
21000490
M
Beef,
liver
0.000290
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
21000491
M
Beef,
liver­
babyfood
0.000290
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
09010750
9A
Cantaloupe
0.151000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
(
PP#
3E6594)
09010800
9A
Casaba
0.151000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Cantaloupe
(
PP#
3E6594)
09020880
9B
Chayote,
fruit
0.116000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Summer
Squash
(
PP#
3E6594)
09021020
9B
Chinese
waxgourd
0.087000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Cucumber
(
PP#
3E6594)
11001290
11
Crabapple
0.124500
1.000
1.000
Ave
FT
Full
comment:
Ave
FT
(
MRID
44539711)
09021350
9B
Cucumber
0.087000
1.000
1.000
Ave.
F
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
16
of
20
Full
comment:
Ave.
FT
(
PP#
3E6594)
23001700
M
Goat,
meat
byproducts
0.001520
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
23001720
M
Goat,
kidney
0.001520
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
23001730
M
Goat,
liver
0.000290
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
95001750
O
Grape
0.425900
1.000
0.050
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44341069/
44889301)
95001760
O
Grape,
juice
0.425900
0.700
0.050
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44341069/
44889301)
95001761
O
Grape,
juice­
babyfood
0.425900
0.700
0.050
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44341069/
44889301)
95001770
O
Grape,
leaves
0.425900
1.000
0.050
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44341069/
44889301)
95001780
O
Grape,
raisin
0.425900
1.400
0.050
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44341069/
44889301)
95001790
O
Grape,
wine
and
sherry
0.425900
1.000
0.050
Ave.
F
Full
comment:
Ave.
FT
(
MRID
44341069/
44889301)
09011870
9A
Honeydew
melon
0.151000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Cantaloupe
(
PP#
3E6594)
11002100
11
Loquat
0.124500
1.000
1.000
Ave
FT
Full
comment:
Ave
FT
(
MRID
44539711)
11002660
11
Pear
0.124500
1.000
0.050
Ave
FT
Full
comment:
Ave
FT
(
MRID
44539711)
11002661
11
Pear­
babyfood
0.124500
1.000
0.050
Ave
FT
Full
comment:
Ave
FT
(
MRID
44539711)
11002670
11
Pear,
dried
0.124500
6.250
0.050
Ave
FT
Full
comment:
Ave
FT
(
MRID
44539711)
11002680
11
Pear,
juice
0.124500
1.000
0.050
Ave
FT
Full
comment:
Ave
FT
(
MRID
44539711)
11002681
11
Pear,
juice­
babyfood
0.124500
1.000
0.050
Ave
FT
Full
comment:
Ave
FT
(
MRID
44539711)
14002690
14
Pecan
0.075000
1.000
0.010
Ave
FT
Full
comment:
Ave
FT
(
MRID
44341071)
09023080
9B
Pumpkin
0.116000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Summer
Squash
(
PP#
3E6594)
09023090
9B
Pumpkin,
seed
0.116000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Summer
Squash
(
PP#
3E6594)
11003100
11
Quince
0.124500
1.000
1.000
Ave
FT
Full
comment:
Ave
FT
(
MRID
44539711)
26003400
M
Sheep,
meat
byproducts
0.001520
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
26003420
M
Sheep,
kidney
0.001520
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
26003430
M
Sheep,
liver
0.000290
1.000
1.000
T.
Blo
Full
comment:
T.
Bloem;
4/
16/
99
09023560
9B
Squash,
summer
0.116000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
(
PP#
3E6594)
09023561
9B
Squash,
summer­
babyfood
0.116000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
(
PP#
3E6594)
09023570
9B
Squash,
winter
0.116000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Summer
Squash
(
PP#
3E6594)
09023571
9B
Squash,
winter­
babyfood
0.116000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Summer
Squash
(
PP#
3E6594)
86010000
O
Water,
direct,
all
sources
0.018760
1.000
1.000
PRZM­
E
Full
comment:
PRZM­
EXAMS
(
EFED
D245120)
86020000
O
Water,
indirect,
all
sources
0.018760
1.000
1.000
PRZM­
E
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
17
of
20
Full
comment:
PRZM­
EXAMS
(
EFED
D245120)
09013990
9A
Watermelon
0.151000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Cantaloupe
(
PP#
3E6594)
09014000
9A
Watermelon,
juice
0.151000
1.000
1.000
Ave.
F
Full
comment:
Ave.
FT
Cantaloupe
(
PP#
3E6594)
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
18
of
20
Cancer
Food
+
Drinking
Water
Results
File
(
w/
Commodity
Contribution
Report
Attached)

U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
KRESOXIM­
METHYL
(
1994­
98
data)
Residue
file
name:
C:\
Documents
and
Settings\
sstanton\
My
Documents\
DEEM­
FCID
Files\
Kresoxim
methyl\
Kresoxim
methyl
Cancer
food
+
water.
R98
Adjustment
factor
#
2
used.
Analysis
Date
05­
24­
2006/
09:
16:
13
Residue
file
dated:
05­
24­
2006/
09:
08:
45/
8
Q*
=
0.0029
COMMENT
1:
Cancer
Assessment
including
proposed
use
on
cucurbit
vegetables
group
9
and
drinking
water.
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Lifetime
risk
Subgroup
body
wt/
day
(
Q*=
.0029)
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.000464
1.34E­
06
U.
S.
Population
(
spring
season)
0.000467
1.35E­
06
U.
S.
Population
(
summer
season)
0.000545
1.58E­
06
U.
S.
Population
(
autumn
season)
0.000425
1.23E­
06
U.
S.
Population
(
winter
season)
0.000416
1.21E­
06
Northeast
region
0.000437
1.27E­
06
Midwest
region
0.000465
1.35E­
06
Southern
region
0.000431
1.25E­
06
Western
region
0.000538
1.56E­
06
Hispanics
0.000522
1.51E­
06
Non­
hispanic
whites
0.000453
1.31E­
06
Non­
hispanic
blacks
0.000425
1.23E­
06
Non­
hisp/
non­
white/
non­
black
0.000612
1.77E­
06
All
infants
(<
1
year)
0.001405
4.08E­
06
Nursing
infants
0.000565
1.64E­
06
Non­
nursing
infants
0.001724
5.00E­
06
Children
1­
6
yrs
0.000721
2.09E­
06
Children
7­
12
yrs
0.000448
1.30E­
06
Females
13­
19
(
not
preg
or
nursing)
0.000322
9.33E­
07
Females
20+
(
not
preg
or
nursing)
0.000455
1.32E­
06
Females
13­
50
yrs
0.000439
1.27E­
06
Females
13+
(
preg/
not
nursing)
0.000430
1.25E­
06
Females
13+
(
nursing)
0.000665
1.93E­
06
Males
13­
19
yrs
0.000345
1.00E­
06
Males
20+
yrs
0.000401
1.16E­
06
Seniors
55+
0.000460
1.33E­
06
Children
1­
2
yrs
0.000771
2.24E­
06
Children
3­
5
yrs
0.000721
2.09E­
06
Children
6­
12
yrs
0.000474
1.37E­
06
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
19
of
20
Youth
13­
19
yrs
0.000335
9.70E­
07
Adults
20­
49
yrs
0.000415
1.20E­
06
Adults
50+
yrs
0.000457
1.32E­
06
Females
13­
49
yrs
0.000420
1.22E­
06
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Kresoxim­
methyl
Dietary
Exposure
and
Risk
Assessment
DP
Number:
329370
PC
Code:
129111
_____________________________________________________________________________________________

Page
20
of
20
Cancer
Commodity
Contribution
Report
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
KRESOXIM­
METHYL
(
1994­
98
data)
Residue
file
name:
C:\
Documents
and
Settings\
sstanton\
My
Documents\
DEEM­
FCID
Files\
Kresoxim
methyl\
Kresoxim
methyl
Cancer
food
+
water.
R98
Adjustment
factor
#
2
used.
Analysis
Date
05­
24­
2006/
09:
16:
18
Residue
file
dated:
05­
24­
2006/
09:
08:
45/
8
Q*
=
0.0029
COMMENT
1:
Cancer
Assessment
including
proposed
use
on
cucurbit
vegetables
group
9
and
drinking
water.
===============================================================================
Critical
Commodity
Contribution
Analysis
for
U.
S.
Population
(
total)

Total
Exposure
=.
0004636
mg/
kg
bw/
day
Crop
groups
with
total
exposure
contribution
>
10%
Foods/
Foodforms
with
exposure
contribution
>
10%
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Crop
group
­­­­­­­­­­­
Exposure
analysis­­­­­­­­­­
Food
mg/
kg
|
%
of
Total|
Lifetime
Risk
Foodform
body
wt/
day|
Exposure
|(
Q*=
.0029)
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­|­­­­­­­­­­­|­­­­­­­­­­­­­­

Crop
Group
=
(
O)
Other
Water,
direct,
all
sources
(
86010000):
FoodForm
N/
S
0.0002276
49.10%
6.60E­
07
Water,
indirect,
all
sources
(
86020000):
FoodForm
N/
S
0.0001678
36.19%
4.87E­
07
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­|­­­­­­­­­­­|­­­­­­­­­­­­­­
Total
for
crop
group
0.0004049
87.32%
1.17E­
06
Crop
Group
=
(
9)
Curcurbit
Vegetables
Total
for
crop
group
0.0000515
11.12%
1.49E­
07
Total
for
crop
groups
listed
above:
0.0004564
98.44%
1.32E­
06
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

1