Document ID: EPA-HQ-OPP-2011-0539-0016
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2012-06-21T04:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

		  WASHINGTON, D.C. 20460

OFFICE OF 	CHEMICAL SAFETY AND POLLUTION PREVENTION

									February 13, 2012

Docket Number:  EPA-HQ-OPP-2011-0539

www.regulations.gov

Errata Sheet for the d-Phenothrin Summary Document (12/19/2011)

In the version of the d-phenothrin Summary Document which was posted in
the public docket, the bullet beginning at the bottom of page 7 is
missing several words of text.  The corrected bullet is provided here
with the missing text underlined.  This typographical error will be
corrected in the Final Workplan for d-phenothrin.

The uncertainty factor (UF) for d-phenothrin for the RED was
1000X for adults (10X for inter-species extrapolation, 10X for
intra-species variation, and 10X for database uncertainty factor for
the inadequate toxicology database i.e., absence of acceptable
neurotoxicity studies).  Under FQPA, the Agency is required to apply a
10X safety factor (SF) to be protective of infants and children unless
there are data to support a reduction or removal.  However, EPA’s
current position is that there is sufficient evidence to reduce the FQPA
SF to 1X for adults and 3X for children <6 years of age.  The 3X is
based on age-dependent-pharmacokinetics and is further supported by
physiologically-based pharmacokinetic (PK) model predictions of a 3-fold
increase of pyrethroid concentration in juvenile target tissue compared
to adults.  A more complete description of the Agency’s reasoning
behind a 3X FQPA SF for children can be found at  HYPERLINK
"http://www.regulations.gov/" www.regulations.gov ;
EPA-HQ-OPP-2011-0746-0011.  These UFs are subject to review and
possible revision during the registration review.