Document ID: EPA-HQ-OPP-2020-0250-0004
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2023-03-24T04:00Z

EPA REGISTRATION DIVISION COMPANY NOTICE OF FILING FOR PESTICIDE PETITIONS PUBLISHED IN THE FEDERAL REGISTER  

EPA Registration Division contact: [Heather McFarley, 202-566-1398, PM 24]

INSTRUCTIONS:  Please utilize this outline in preparing the pesticide petition.  In cases where the outline element does not apply, please insert "NA-Remove" and maintain the outline. Please do not change the margins, font, or format in your pesticide petition. Simply replace the instructions that appear in green, i.e., "[insert company name]," with the information specific to your action.

TEMPLATE:

BASF Corporation

[Insert petition number]

	EPA has received a pesticide petition ([#2F9021]) from BASF Corporation, 26 Davis Drive, Research Triangle Park, NC 27709 proposing, pursuant to section 408(d) of the Federal Food, Drug, and Cosmetic Act (FFDCA), 21 U.S.C. 346a(d), to amend 40 CFR part 180.473 by: modifying the tolerances for residues of glufosinate to include residues of L-glufosinate-ammonium, glufosinate-P-ammonium [(2S)-2-amino-4-(hydroxymethylphosphinyl) butanoic acid -monoammonium salt] as measured by the sum of glufosinate (2-amino-4-(hydroxymethylphosphinyl)butanoic acid) and its metabolites, 2- (acetylamino)-4-(hydroxymethyl phosphinyl) butanoic acid, and 3- (hydroxymethylphosphinyl) propanoic acid, expressed as 2-amino-4-(hydroxymethylphosphinyl)butanoic acid equivalents  in or on raw agricultural commodities canola, meal at 1.1 ppm; rapeseed  subgroup 20A at 0.4 ppm; cattle, fat at 0.4 ppm; cattle, meat, at 0.15 ppm; cattle, meat byproducts at 6 ppm; corn, field forage at 4 ppm; corn, field, grain at 0.2 ppm; Corn, field, stover at 6 ppm; Corn, sweet, forage at 1.5 ppm; Corn, sweet, kernels plus cob with husks  removed at 0.3 ppm; corn, sweet, stover at 6 ppm; cotton, gin byproducts at 30 ppm; cotton seed subgroup 20C at 15 ppm; egg at 0.15 ppm; goat, fat at 0.4 ppm; goat, meat at 0.15 ppm; goat, meat byproducts at 6 ppm; grain aspirated fractions at 25 ppm; hog, fat at 0.4 ppm; hog, meat at 0.15 ppm; hog, meat byproducts at 6 ppm; horse, fat at 0.4 ppm; horse, meat at 0.15 ppm; horse, meat  byproducts at 6 ppm; milk at 0.15 ppm; poultry, fat at 0.15 ppm; poultry, meat at 0.15 ppm; poultry, meat byproducts at 0.6 ppm; sheep, fat at 0.4 ppm; sheep, meat at 0.15 ppm; sheep, meat byproducts at 6 ppm; soybean at 2 ppm; soybean, hulls at 10 ppm; and indirect or  inadvertent residues of glufosinate on barley, hay at 0.4 ppm; barley, straw at 0.4 ppm; buckwheat, fodder at 0.4 ppm; buckwheat, forage at 0.4 ppm; oat, forage at 0.4 ppm; oat, hay at 0.4 ppm; oat, straw at 0.4 ppm; rye, forage at 0.4 ppm; rye, straw at 0.4 ppm; teosinte at 0.4 ppm; triticale at 0.4 ppm; wheat, forage at 0.4 ppm; wheat, hay at 0.4 ppm; and wheat, straw at 0.4 ppm.

EPA has determined that the petition contains data or information regarding the elements set forth in section 408 (d)(2) of FDDCA; however, EPA has not fully evaluated the sufficiency of the submitted data at this time or whether the data supports granting of the petition. Additional data may be needed before EPA rules on the petition.

A. Residue Chemistry

	1. Plant metabolism. The uptake and metabolism of glufosinate ammonium (racemic mixture) and L-glufosinate ammonium in primary crops is adequately understood. Radiolabeled studies with glufosinate ammonium, which includes L-glufosinate ammonium, have been conducted in various plants all showing similar results. The relevant residues are parent glufosinate, including L-glufosinate, and MPP (3-(hydroxymethylphosphinyl) propanoic acid) in conventional plants and additionally NAG (N-acetyl glufosinate, 2- (acetylamino)-4-(hydroxymethyl phosphinyl) butanoic acid) in glufosinate-tolerant plants.

	2. Analytical method. Glufosinate-ammonium including L-Glufosinate-ammonium and the two metabolites 2- (acetylamino)-4-(hydroxymethyl phosphinyl) butanoic acid (NAG) and 3-(hydroxymethylphosphinyl) propanoic acid (MPP), expressed as 2-amino-4-(hydroxymethylphosphinyl)butanoic acid equivalents (glufosinate acid equivalents) are the residues of concern in plant and livestock commodities required for analysis based on the metabolic profiles.  The current analytical methods involve water extraction, filtration, and addition of an isotopically labeled internal standard followed by solid phase extraction.  The method does not separate the isomers of glufosinate, and quantitation is by high performance liquid chromatography-electrospray ionization/tandem mass spectrometry (LC/MS/MS).  

	3. Magnitude of residues.  No new residue trials were performed for this petition.  

B. Toxicological Profile
NA, remove

C. Aggregate Exposure

 NA, remove 

D. Cumulative Effects
NA, remove

E. Safety Determination
NA, remove.

F. International Tolerances
NA, remove.