Document ID: EPA-HQ-OPP-2004-0257-0005
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2007-07-27T04:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF

PREVENTION, PESTICIDES, AND

TOXIC SUBSTANCES

MEMORANDUM

DATE:	June 13, 2007

SUBJECT:	PP#3E6795.  Chlorothalonil:  Errata to Risk Assessment for a
Tolerance on Edible-Podded Peas Without a U.S. Registration.  

DP Barcode:  D340577    					PC Code:  081901

FROM:	

William Greear, M.P.H., D.A.B.T., Toxicologist

Registration Action Branch 1 (RAB1)

Health Effects Division (HED) (7509P)

THROUGH:	P.V. Shah, Ph.D., Acting Branch Chief

RAB1/HED (7509P)

TO:		Tony Kish/Rosemary Kearns, RM 22

	Registration Division (RD; 7505P)

There were a couple of issues that required clarification in this risk
assessment.  The following addresses theses issues re. toxicology
issues.

Erratum No. 1

There were several toxicity studies that were mentioned in the risk
assessment as not have been reviewed at that time (see pages 18 and 19
of the risk assessment document, DP# 337925, 3/16/2007).  They had been
under review, but had not been finalized. Their reviews have now been
completed. The studies were:

Schroeder, R. (1998) SDS-3701: A developmental toxicity study in rats
via oral administration.  Huntingdon Life Sciences, East Millstone, New
Jersey 08875, Laboratory report number CTL/C/3921, June 12, 1998.  MRID
45331001.  Unpublished.

Schetter, J., Yoshida, M. and Watson, M. (2000) A 52-Week Oral Toxicity 
   Study in Dogs with SDS-3701. Ricerca, Inc., 7528 Auburn Road,
Painesville, OH 44077. Ricerca Study No. 97-0102, January 31, 2000. MRID
45491101. Unpublished.	

The results of the studies were accurately reflected in the risk
assessment document on chlorothalonil dated March 16, 2007 with the
exception that the NOAEL/LOAEL for males in the chronic dog study was
reduced to 0.83/1.80 mg/kg/day, whereas in the table the NOAEL/LOAEL was
reported as 1.8/3.26 mg/kg/day.  There were no other changes to the
NOAELs or the LOAELs in either study.

[See memorandum of W. Greear dated June 13, 2007, TXR# 0054574, DP#
338049]

Erratum No.2

The “FQPA SF” referred to in Table 3.5.1. Summary of Toxicological
Doses and Endpoints for Chlorothalonil Used in Human-Health Risk
Assessments, should be interpreted to equate to “Special FQPA SP”. 
However, please note that HED no longer uses the term :Special FQPA
SF”.

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