Document ID: EPA-HQ-OPPT-2022-0918-0003
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2023-02-16T05:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY (USEPA)
                SCIENCE ADVISORY COMMITTEE ON CHEMICALS (SACC)
                                       
Review of two draft documents entitled: "Draft Proposed Principles of Cumulative Risk Assessment Under the Toxic Substances Control Act" and "Draft Proposed Approach for Cumulative Risk Assessment of High-Priority Phthalates and a Manufacturer Requested Phthalate Under the Toxic Substance Control Act.
                                May 8-11, 2023
                                       
             List of Candidates (including Biographical Sketches)
                     Docket Number: EPA-HQ-OPPT-2022-0918
                                       
Note: This list of candidates includes all interested and available nominees under consideration as prospective ad
hoc reviewers. USEPA will screen candidates based on the selection criteria in the Federal Register of December 21, 2022 (87 FR 78103).
Public comments must be submitted through regulations.gov. Follow the online instructions for submitting comments. Do not electronically submit any information you consider to be Confidential Business Information or other information whose disclosure is restricted by statute. Copyrighted material will not be posted without explicit permission of the copyright holder. Members of the public should also be aware that personal contact information, if included in any written comments, may be posted on the internet.

                    El'gin W. Avila, PhD (ABD), MPH, CPH
 
Affiliation: 
Director, Environmental and Occupational Health & Equity, BlueGreen Alliance, Tucson, Arizona; Minnesota Pollution Control Agency (Remote); University of Minnesota- NIOSH Research Fellow (Remote)

Expertise: 
Industrial Hygiene; Occupational Health; Environmental Health; Exposure Assessment; Risk Management and Evaluation; Environmental Justice and Equity; Mixed Methods Approaches; Expertise in comprehensive and holistic approaches to environmental and occupational health 

Education: 
PhD (expected in 2023) in Industrial Hygiene, University of Minnesota; MPH in Environmental Health Science & Policy, George Washington University; BS in Psychology, Eastern Michigan University 

Experience Summary: 
Mr. El'gin Avila has over 8 years of experience in environmental health sciences and serves on various councils and committees for local, not-for-profit, and academic organizations including Network for Energy, Water and Health in Affordable Buildings'  Stewardship council, and has served as a consultant on occupational exposure control projects for Federal Occupational Safety and Health Administration's (OSHA's) COVID respiratory protection program, and environmental health assessment and evaluation projects for local agencies in Minnesota and Arizona. Mr. Avila's research interests include cumulative exposures, industrial hygiene, and holistic approaches to improving health and wellness for historically disadvantaged and marginalized working populations. Additionally, he focuses on improving access to resources via technical assistance programs and establishing community partnerships to improve community resiliency. 
 
Panel Experience: 
N/A; Participated in USEPA's Toxic Substances Control Act (TSCA) Occupational Exposure Workshop (Jan. 2023)

                            Michael A. Babich, PhD
                                       
Affiliation:
Director, Division of Toxicology & Risk Assessment, U.S. Consumer Product Safety Commission (retired February 2023), Rockville, Maryland

Expertise: 
Risk assessment

Education: 
PhD in Bioorganic Chemistry, Pennsylvania State University; MS in Chemistry, Pennsylvania State University; BA in Chemistry, La Salle University.

Experience Summary: 
Dr. Michael Babich served as the Director of the Division of Toxicology & Risk Assessment at the U.S. Consumer Product Safety Commission (CPSC) from 2013 until his retirement in 2023. He previously served as a staff scientist at CPSC, where he was the principal author of numerous CPSC exposure and risk assessments involving chronic hazards associated with consumer products, including flame retardant chemicals in upholstered furniture and diisononyl phthalate in children's products. He has managed numerous regulatory and research projects, including the CPSC chronic hazard risk assessment guidelines, and the Chronic Hazard Advisory Panel on phthalates, and coordinated the agency's Chemical Hazards Program for 9 years. This work contributed to the development of seven federal regulations, four national voluntary standards, and the CPSC risk assessment guidelines. Prior to joining CPSC, Dr. Babich was engaged in basic research in the field of carcinogenesis, mutagenesis, and DNA repair. Dr. Babich received postdoctoral training at the University of Rochester Medical Center and the National Cancer Institute, National Institutes of Health. He previously worked as a Research Associate at the Armed Forces Radiobiology Research Institute.

Panel Experience: 
Interagency Scientific Review Group, Report on Carcinogens, National Toxicology Program (NTP), 2008-2010; Study Design Groups for Antimony Trioxide and Tris(2-chloropropyl) Phosphate, National Toxicology Program, 2007; Peer reviewer for "Interaction Profile for Carbon Monoxide, Formaldehyde, Methylene Chloride, Nitrogen Dioxide, and Tetrachloroethylene" and "Interaction Profile for Chloroform, 1,1-Dichloroethylene, Trichloroethylene, and Vinyl Chloride," Agency for Toxic Substances and Disease Registry, 2007; Federal Technical Advisor, High Production Volume Chemical Workgroup, National Pollution Prevention and Toxics Advisory Committee (NPPTAC), USEPA, 2005

                            Michael J. Bartels, PhD
Affiliation:
Senior Consultant, ToxMetrics.com LLC, Midland, Michigan

Expertise: 
Toxicokinetics; Analytical Chemistry and Biological Modeling of Systemic Exposures; Toxicokinetic studies; Exposure and biomonitoring evaluations of commercial products

Education: 
PhD in Medicinal Chemistry, University of Washington, Seattle; Postdoctoral Fellow, Baylor College of Medicine, Houston; BS in Chemistry, Bemidji State University, Minnesota.

Experience Summary: 
Dr. Michael Bartels has numerous industry-wide activities in exposure assessment and/or biomonitoring (American Chemistry Council (ACC), Crop Life America), as well as biological modeling and metabolism (ACC, European Chemical Industry Council, US Centers for Disease Control and Prevention, National Center for Environmental Health). Expert panel activities have included a workshop on the Derivation of Biomonitoring Equivalents, and chair of a Continuing Education course on Toxicokinetics at the Society of Toxicology (SOT) meeting in 2009. He has been a presenter at numerous USEPA Science Advisory Panel meetings. He has authored/coauthored over 125 publications and book chapters, primarily in the field of bioanalytical chemistry, xenobiotic metabolism, toxicokinetic modeling and biomonitoring. Dr. Bartels' current research interests are in the mechanistic basis for nonlinear toxicokinetics in regulatory toxicity testing and standardization of physiologically based pharmacokinetic (PBPK) exposure modeling methods for improved regulatory acceptance.

Panel Experience: 
USEPA/National Science Foundation  peer-review panel member Environmental Research PBPK modeling in biomonitoring assessment, 1996, 1998, 2007; National Institutes of Health Study Section member Metabolomics Technology Development Metabolomic Analysis for Disease Markers, 2004-2009; Metabolomics: Application to Environmental Health Research, National Center for Toxicogenomics; Proteomics Biomarker Identification National Center for Complementary and Alternative Medicine: Omics and Variable Responses to CAM 2013: Committee member, Antimicrobials PPDC 21st Century Toxicology/New Integrated Testing Strategies Workgroup Biomonitoring Subgroup (USEPA) 2020-2022: Workgroup member, International Life Sciences Institute/Health and Environmental Sciences Institute (ILSI/HESI) project on Kinetically Derived Maximum Dose in Toxicology

                             Jonathan W. Boyd, PhD

Affiliation:
Professor and John A. Cardea Chair, Orthopaedic Surgery and Professor, Pharmacology & Toxicology, Virginia Commonwealth University (VCU) School of Medicine, Richmond, Virginia

Expertise: 
Biochemistry; Toxicology; Physiology; Signal Transduction; Clinical Translation

Education: 
PhD in Environmental Toxicology, Texas Tech University; BS in Biochemistry, University of Texas at Austin

Experience Summary: 
Dr. Jonathan Boyd is the Cardea Professor of Orthopaedic Surgery at the Virginia Commonwealth University (VCU) School of Medicine. Additionally, he holds appointments in the Department of Pharmacology and Toxicology and the Department of Biomedical Engineering at VCU, and he serves on the Advisory Board of the Center for Inhalational Toxicology at the West Virginia University School of Medicine. In his research, Dr. Boyd uses fundamental signaling principles to investigate mechanisms of toxicity where his goal is to understand molecular impacts on functionality and systemic robustness. This unique research focus enabled Dr. Boyd to work translationally across multiple hierarchal levels of biological samples that include mammalian cell culture, various animal models and human subjects, coupled with a multitude of analytical techniques that range from high-throughput assays to state-of-the-art imaging. As a basic scientist the application of his research is broad and spans toxicity screening to medical diagnostics and inflammation-related disease etiology. In addition to the panel experience listed below, Dr. Boyd has served on several state and national society special topic sessions, specifically in the areas of analytical and mixtures toxicology

Panel Experience: 
National Institute of Occupational Safety and Health review panel for the Alice Hamilton Awards; research grant reviewer for: Army Research Office (2019-present); Centers for Disease Control and Prevention (2018-present); European Research Council Advanced Grants Section (2015-2020); USEPA Science to Achieve Results (2013, 2015); and the American Association for the Advancement of Science Homeland Security and Defense (2006)

                        Joseph M. Braun, RN, MSPH, PhD

Affiliation:
Associate Professor, Department of Epidemiology, Brown University, Providence, Rhode Island

Expertise: 
Epidemiology; Chemical Mixtures; Pediatrics; Endocrine Disruptors; Exposure Assessment; Obesity; Neurodevelopment

Education: 
BS in Biochemistry, University of Wisconsin, Madison; BS in Nursing, University of Wisconsin, Milwaukee; MSPH in Epidemiology, University of North Carolina, Chapel Hill; PhD in Epidemiology, University of North Carolina, Chapel Hill

Experience Summary: 
Dr. Joseph Braun is an Associate Professor in the Department of Epidemiology and Director of the Center for Children's Environmental Health at the Brown University School of Public Health. He was formerly a school nurse in Milwaukee, Wisconsin, before receiving his master's and doctoral degrees in Epidemiology from the University of North Carolina, Chapel Hill. He completed postdoctoral training in environmental health at the Harvard School of Public Health. For 17 years, Dr. Braun has been identifying modifiable risk factors of pediatric diseases. Working with an interdisciplinary team that includes epidemiologists, biostatisticians, exposure scientists, physicians, and engineers, he studies the health effects of environmental pollutant exposures before conception and during gestation, infancy, childhood, and adolescence. Dr. Braun's research foci include endocrine disrupting chemicals, toxic metals, obesity, cardiometabolic health, and pediatric neurodevelopmental disorders. His research group applies advanced biostatistical techniques to longitudinal cohort studies for quantifying the health effects of chemical mixtures and identify periods of heightened susceptibility to chemical exposures. Moreover, Dr. Braun is using untargeted metabolomics and DNA methylation to understand biological pathways underlying the potential effect of chemical exposures. Dr. Braun is currently the chair of the Social and Environmental Determinants of Health Study Section, National Institutes of Health (NIH). In addition to the panel experience listed below, Dr. Braun served as an ad hoc reviewer on 6 other NIH study sections

Panel Experience: 
Served as an ad hoc reviewer on six other National Institutes of Health study sections. USEPA's Integrated Science Assessment for Pb (2022); National Toxicology Program (NTP) report on the Immunotoxicity Associated with Exposure to PFOA or PFOS (2016). NTP/Office of Dietary Supplements panel on Identifying Research Needs for Assessing Safe Use of High Intakes of Folic Acid and a co-author of the associated monograph (2015)

                              James Bruckner, PhD

Affiliation:
Professor Emeritus of Pharmacology and Toxicology, University of Georgia, Athens, Georgia

Expertise: 
Toxicology and pharmacokinetics of persistent organic pollutants, organic solvents and pesticides; Potential adverse health effects involving chemical interactions; and the influence of physiological/biochemical changes during maturation on target organ deposition of environmental contaminants 

Education: 
PhD in Toxicology, University of Michigan, Ann Arbor; BS and MS in Pharmacy and Toxicology, University of Texas, Austin 
 
Experience Summary: 
Dr. James Bruckner was Professor of Pharmacology and Toxicology at the University of Georgia (UGA) for 36 years.  He organized and served as Director of the UGA Interdisciplinary Toxicology Program from 1985-1998.  He was previously a member of the faculty of the University of Texas Medical School at Houston for 8 years.  Dr. Bruckner has been a member of a wide variety of national and international scientific advisory committees and boards, expert panels, committees, and working groups for the USEPA; National Institute of Environmental Health Sciences; National Aeronautics and Space Administration; U.S. Air Force; Agency for Toxic Substances and Disease Registry, Center for Disease Control and Prevention; Food and Drug Administration; and National Academy of Sciences (NAS) (as detailed in examples below).  Dr. Bruckner also was a Fellow of the Academy of Toxicological Sciences and served on editorial boards of Toxicology and Applied Pharmacology, the Journal of Toxicology and Environmental Health, Toxicology, Chemosphere, and the International Journal of Toxicology.

Panel Experience: 
USEPA Chlorpyrifos PBPK-PD Modeling, Scientific Advisory Panel (2011); Organophosphate Pesticides: Preliminary OP Cumulative Risk Assessment, Scientific Advisory Panel (2002);  National Academy of Sciences Committees on Safe Drinking Water (1983-85), Pesticides in the Diets of Infants and Children (1988-1994), Health and Safety Consequences of Child Labor (1997-1998), Human Research Participants (2002-2003), Acute Exposure Guideline Levels for Hazardous Substances (1998-2006), Contaminated Drinking Water at Camp Lejeune (2007-2009), and Committee on Toxicology (2004-2011)

                            Antonia M. Calafat, PhD

Affiliation:
Chief, Organic Analytical Toxicology Branch, Division of Laboratory Sciences at the Centers for Disease Control and Prevention (CDC), Atlanta, Georgia

Expertise: 
Human exposures to environmental chemicals including phthalates with a focus on biomonitoring and public health 

Education: 
PhD in Chemistry, University of the Balearic Islands (UBI), Spain; MS in Chemistry, UBI; BS in Chemistry, UBI
 
Experience Summary: 
Dr. Antonia Calafat has 26 years of laboratory biomonitoring science expertise at CDC. She established and led world-recognized biomonitoring programs at CDC to assess chemical exposures of public health concern (e.g., phthalates and other plasticizers, PFAS, bisphenol A, pesticides). She leads CDC's biomonitoring programs for assessing human exposure to chemicals added to consumer and personal-care products such as phthalates and phenols; flame retardants; pesticides; polycyclic aromatic hydrocarbons; and persistent organic pollutants including polybrominated diphenyl ethers; polychlorinated dibenzo-p-dioxins, furans, and biphenyls; and PFAS. In 2019, Dr. Calafat received the Excellence in Exposure Science Award given by the International Society of Exposure Science. Since 2017, she is the co-Editor-in-Chief of the International Journal of Hygiene and Environmental Health.

Panel Experience: 
Food and Agriculture Organization/World Health Organization (FAO/WHO) Expert Meeting on Bisphenol A (Ottawa, Canada) (November 2010) as vice-chairperson; U.S. Food and Drug Administration Science Board Bisphenol A Subcommittee (August 2008 - October 2008); Center for the Evaluation of Risks to Human Reproduction of the National Toxicology Program expert panel to evaluate the reproductive and developmental toxicity of genistein and soy formula (March 2006)

                             Raymond M. David, PhD
                                       
Affiliation:
Principal, David Tox, LLC, Sarasota, Florida

Expertise: 
Mammalian Toxicology

Education: 
PhD in Pharmacology, University of Louisville; MS in Biology, Loyola University of Chicago; BS in Biology, Marquette University

Experience Summary: 
Dr. Raymond David has been an independent consultant for 6 years and is an adjunct (courtesy) professor at the University of Florida, Department of Physiological Sciences, College of Veterinary Medicine. Dr. David retired from the Manager of Toxicology for Industrial Chemicals position at BASF Corporation in 2016. Dr. David worked for 8 years (1983-1991) at Microbiological Associates in Bethesda, Maryland where he managed the Inhalation and Mammalian Toxicology Departments. He later moved to Eastman Kodak in Rochester, New York, where he worked as Senior Toxicologist for over 14 years (1991-2006). At Kodak, Dr. David was responsible for scientific stewardship of phthalate esters at Eastman Kodak, and that responsibility extended to BASF. Dr. David has over 15 years of experience studying the toxicology of phthalates and has published 14 peer-reviewed papers and 3 book chapters on phthalate esters toxicology. He has participated in the American Chemistry Council's Phthalate Esters Panel as chair of the toxicology research group, and has provided information on phthalates to the media, and state and federal legislative bodies. Dr. David was also an observer to the International Agency for Research on Cancer (IARC) Working Group in 2000 which reviewed di(2-ethylhexyl) phthalate (DEHP) and di(2-ethylhexyl) adipate (DEHA). Dr. David was certified by the American Board of Toxicology in 1985 and subsequently recertified in 1990, 1995, 2000, 2005, 2010, and 2015.

Panel Experience: 
Expert Panel of the Center for Evaluating Risks to Human Reproduction for 1-bromopropane (2001); Industry observer to the IARC Working Group on Carcinogens (1998, 2000)
                           Stephanie, M. Engel, PhD
                                       
Affiliation:
Professor of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

Expertise: 
Environmental epidemiology, Perinatal and neurodevelopmental epidemiology

Education: 
BA in Psychology, University of California at San Diego; BS in Animal Physiology and Neuroscience, University of California at San Diego; MSPH in Epidemiology, University of North Carolina at Chapel Hill; PhD in Epidemiology, University of North Carolina at Chapel Hill

Experience Summary: 
Dr. Stephanie Engel is a Professor of Epidemiology, with 20 years of research and teaching experience in perinatal and environmental epidemiology. She is the current Director of an EPA-funded Early Life Center, principal investigator of multiple NIH-funded R01s, and Deputy Director of the National Institute of Environmental Health Sciences (NIEHS)-funded P30 Center for Environmental Health and Susceptibility. She has graduated 8 doctoral students, 6 master's students, and served on the doctoral committee of over 20 additional students across multiple academic disciplines, from toxicology to biostatistics. Dr. Engel's research considers the impact of environmental exposures and innate susceptibility factors on adverse pregnancy outcomes and neurodevelopmental impairment in children. She has led multiple national and international studies of prenatal and early life toxicant exposures in relation to child development, has over 130 peer reviewed publications, and has led collaborative research amounting to over $11M in federal funding. Her research expertise is particularly focused on endocrine disrupting compounds and complex exposure mixtures, utilizing biomarkers of exposure to estimate associations with neurodevelopmental outcomes.

Panel Experience: 
NIH/CSR Study Sections: Temporary Member: ZRG1 IRAP-Q 01 (June 2009), ZRG1 PSE-F 95 (S), (June 2009), ZES1 SET-V 01; NIEHS: "Assessing and Addressing Community Exposures to Environmental Contaminants", (July 2009); ZRG1 IRAP-Q 01 (June 2010); ZRG1 IRAP-Q 01 (June 2010); ZRG1-SPSS (Feb 2012); ZRG1-NAME (Feb 2013); ZRG1-NAME (Dec 2013); NIEHS Special Emphasis Panel for Career Awards (K22 & K23) ZES1 LKB-D (C) 1 (April 2016), ZRG1-IRAP (Feb 2016); NIH Fellowships: Risk, Prevention and Health Behavior ZRG1 F16-M (09) F (March 2017); Standing Member: ZRG1-IRAP (2017-2021). Other Workgroups include: Member of Endocrine Disruptors Workgroup, "Optimizing Expose Metrics for the National Children's Study" (2010); Member, Institute of Medicine (IOM) Committee for the Review of the Health Effects in Vietnam Veterans of Exposure to Herbicides 9th Biennial Update (2012-2014); Reviewer, Division of Intramural Population Health Research (DIPHR), National Institute of Child Health and Human Development (NICHD) (2016); External Advisory Board Member (Mount Sinai NIEHS P30)(2017-ongoing); Chair, External Advisory Board, Center for Population Health Research, University of Montana
                             Mary A. Fox, PhD, MPH
                                       
Affiliation:
Assistant Professor and Co-Director, Risk Sciences and Public Policy Institute Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland

Expertise: 
Human Health Risk Assessment: Applying epidemiological methods and data to understand combined exposures to chemical and non-chemical stressors for cumulative risk assessment

Education: 
PhD, Environmental and Occupational Health Policy, Johns Hopkins University; MPH, Environmental Studies, University of Rochester; BS, Biology, State University of New York at Albany

Experience Summary: 
Dr. Mary Fox is an Assistant Professor in the Department of Health Policy and Management and the co-director of the Risk Sciences and Public Policy Institute at the Johns Hopkins Bloomberg School of Public Health. She has 18 years of experience teaching as core faculty of the Risk Sciences certificate program leading courses in quantitative risk assessment methods and risk policy, management, and communication. Dr. Fox's research is focused on human health risk assessment as a part of environmental policy making, particularly approaches to cumulative and chemical mixtures risk assessment. Dr. Fox has made key contributions to the development and application of cumulative risk methods to inform community environmental health and environmental justice and occupational health policies. Dr. Fox has expertise in risk assessment of air toxics, metal mixtures, phthalates, volatile organic solvents and PCBs. Dr. Fox has served on four National Academies' committees: Veterans and Agent Orange, Update 11 (2017-2018); Gulf War and Health, Volume 10: Update of Health Effects of Serving in the Gulf War (2014-2016); Long-Term Health Consequences of Exposure to Burn Pits in Iraq and Afghanistan (2010-2011); and Phthalates and Cumulative Risk Assessment: The Tasks Ahead (2007-2008).

Panel Experience: 
NIEHS P42 Superfund Review (2016); Agency for Toxic Substances and Disease Registry, Camp Lejeune Drinking Water Public Health Assessment (2015); USEPA, Community-Focused Exposure and Risk Screening Tool (C-FERST) (2013); U.S. FDA, Center for Food Safety and Nutrition iRisk Model (2013); NIEHS Children's Environmental Health and Disease Prevention Research Review (2012); USEPA, Office of Water's "Fluoride: Exposure and Relative Source Contribution Analysis" (2010); USEPA and Department of Agriculture, "Risk Assessment of Spent Foundry Sands in Soil-Related Applications (2009); U.S. Pharmacopeial Convention (USP), Expert Panel on Dietary Supplements Safety Modeling (2013-2014); USEPA Science Advisory Board ad hoc Perchlorate Advisory Panel (2012-2013); USEPA Peer Consultation Workshop on Cumulative Risk Assessment of Phthalates (2010); Four National Academies' committees: Veterans and Agent Orange, Update 11 (2017-2018); Gulf War and Health, Volume 10: Update of Health Effects of Serving in the Gulf War (2014-2016); Long-Term Health Consequences of Exposure to Burn Pits in Iraq and Afghanistan (2010-2011); and Phthalates and Cumulative Risk Assessment: The Tasks Ahead (2007-2008)

                           Katy O. Goyak, PhD, DABT
Affiliation:
Toxicologist, ExxonMobil Biomedical Sciences, Inc., Annandale, New Jersey

Expertise: 
Toxicology; Human health risk assessment; Uncertainty analysis; New approach methodologies; Adverse outcome pathways; Mode of action assessment; Weight of evidence assessments; Chemicals mixtures risk assessment 

Education: 
Diplomate of the American Board of Toxicology (DABT) certification (October 2013); PhD in Pathobiology, Pennsylvania State University (November 2008); BS in Biochemistry/Molecular Biology, Gettysburg College (May 2003)
 
Experience Summary: 
Dr. Katy Goyak is a Toxicologist with ExxonMobil Biomedical Sciences, Inc., where she has supported scientific programs related to fuels, lubricants, and industrial chemical products for approximately 14 years. Her primary research interests are on the use of new approach methodologies (NAM) in human health risk assessment, with a focus on the utility of adverse outcome pathways (AOPs) as a means to integrate NAM-based data with more traditional animal-derived data. Dr. Goyak has employed software-assisted literature tools (e.g., Health Assessment Workspace Collaborative (HAWC), Sciome Workbench for Interactive computer-Facilitated Text-mining (SWIFT-Review), and DistillerSR) as a means to increase efficiency and transparency of the literature review and weight of evidence steps in her recent risk assessment projects (2019-present, see OSF public projects/preprints). Her hazard and risk assessment projects have included complex and variable substances (e.g., mineral oils (Adenuga et al., 2017), formulated products considered mixtures (Arnold et al., 2017), and structurally related substances considered as chemical classes (Open Science Framework (OSF) public project on alkylphenols)). Dr. Goyak has been engaged in the Organisation for Economic Co-operation and Development (OECD) AOP program and review process. In addition, Dr. Goyak attended joint USEPA and American Chemistry Council meetings on various phthalates topics as an industry expert on the toxicology of phthalates (e.g., Manufacturer Requested Risk Assessment of di-isononyl phthalate and di-isodecyl phthalate). She is on the editorial board for Toxicology Letters (2021-present), is an active peer reviewer for various toxicology journals. 

Panel Experience: 
USEPA's Science Advisory Committee on Chemicals (SACC) peer-review of the Systematic Review protocol (April 19-21, 2022); American Chemical Council's High Phthalates Panel; and Business and Industry Council participant in the OECD's Expert Advisory Group on Molecular Screening and Toxicogenomics (since 2015) attended joint agency and American Chemical Council meetings on various phthalates topics as an industry expert on the toxicology of phthalates (e.g., Manufacturer Requested Risk Assessment of di-isononyl phthalate and di-isodecyl phthalate)
                          Richard, C, Hertzberg, PhD
Affiliation:
Private consultant (Biomathematics Consulting), Atlanta, Georgia

Expertise: 
Biomathematics research developing dose-response methods to address toxicological interactions in chemical mixtures, and quantitative methods for health risk assessment of chemical mixtures 

Education: 
PhD in Biomathematics, University of Washington; BS in Mathematics, Harvey Mudd College
 
Experience Summary: 
Dr. Richard Hertzberg is a private consultant with 17 years of experience working on federal and private contracts in the area of health risk assessment of chemical mixtures. He was an adjunct professor in Environmental Health at Emory University and taught the graduate course Risk Assessment I (2006-2014). Previously he was a mathematical statistician at the USEPA Office of Research and Development leading the research program on risk assessment methods for chemical mixtures (1980-2006), including chairing the committee that wrote the 1986 chemical mixtures guidelines and the 2000 update (Supplementary Guidance), and co-authoring the 2003 Cumulative Risk Assessment Framework. He served a Special Term Appointment (2012-2015) at Argonne National Laboratory, where he contributed to methods and guidance on cumulative health risk assessment and to evaluations of greenspace health benefits and impacts. He served as adjunct faculty on PhD committees at Carnegie-Mellon (2006-08) and Texas A&M (1997-98) Universities, and on MS or MPH committees at Emory (2006-07) and Northwestern (1999-2000) Universities. He co-taught workshops on mixture risk assessment at the Society for Risk Analysis (2000-2021) and Society of Toxicology (2015, 2017, 2021). His research focus is defensible quantitative methods for mixtures risk.

Panel Experience: 
External review panel of mixture risk guidance and interaction profiles, Agency for Toxic Substances and Disease Registry (1998-2002); Expert review panel on mixture risk, Health Council of the Netherlands (1999-2002); External advisory committee, National Institute for Occupational Safety and Health- Mixed Exposure Research Team (1998-2006); Expert review panel on the sulfolane reference dose for Alaska Department of Environmental Conservation (2014).

                         Kembra L. Howdeshell, MS, PhD
Affiliation:
Health Scientist at the Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina

Expertise: 
Developmental and Reproductive Toxicology; Endocrine Disruption; Mixtures Toxicology

Education: 
PhD in Biology, University of Missouri-Columbia; MS in Biological Sciences, Emporia State University, Emporia, KS; BS in Biology at Friends University, Wichita, Kansas
 
Experience Summary: 
Dr. Kembra Howdeshell is a Health Scientist in the Division of Translational Toxicology (DTT) (formerly the Division of the National Toxicology Program) at the National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, with 19 years of experience working as a toxicologist. She is a member of the Combined Exposures and Mixtures Program Management Team, which develops, reviews, and manages the mixtures research portfolio at the DTT, NIEHS (2020-present). Dr. Howdeshell is an active ad hoc Peer Reviewer for many journals and has served as Guest Editor for Birth Defect Research Journal (2017). She has served as a Discussant at the USEPA Workshop, "Cumulative Risk Assessment of Phthalates," (December 2010), a Reviewer for the European Human Biomonitoring Initiative HBM4EU Workshop on mixture assessment of certain phthalates within the scope of task 5.2  -  derivation of human biomonitoring guidance values (November 2020). Her primary research interests include developmental and reproductive toxicology, endocrine disruption, and mixtures toxicology.

Panel Experience: 
N/A; Experience serving on a committee/panel style peer review. 

                       Eric S.C. Kwok, MPhil, PhD, DABT

Affiliation:
Senior Toxicologist of the Exposure Assessment Section and the Human Exposure & Health Effect Modeling Section at the California Department of Pesticide Regulation, Sacramento, California

Expertise: 
Pesticide human health risk assessment; Pesticide exposure assessment in humans; Statistical analysis of data from FIFRA guideline mammalian toxicology studies and human exposure studies

Education: 
PhD in Environmental Toxicology, University of California, Riverside; MPhil in Biology, The Chinese University of Hong Kong; BSc (Hons) in Zoology (major) and Botany (minor), University of Hong Kong
 
Experience Summary: 
Dr. Eric Kwok is a Senior Toxicologist of both the Exposure Assessment Section and Human Exposure & Health Effect Modeling Section at the California Department of Pesticide Regulation, where he supervises a team of modelers and toxicologists to conduct pesticide exposure assessments on agricultural handlers, reentry workers, and bystanders. Dr. Kwok has a combined 22 years of experience in conducting human exposure and health risk assessments of pesticides using different computational tools including stochastic human exposure assessment models and physiologically based pharmacokinetic models as well as performing statistical analyses on data derived from the Federal Insecticide, Fungicide, and Rodenticide Act guideline toxicology and exposure studies. Dr. Kwok has been a Diplomate of the American Board of Toxicology since 2006. His research focuses include applying 21st century computational techniques for characterizing pesticide exposures in humans based on human activities, product formulations, and use patterns. Dr. Kwok has published 40 peer reviewed scientific papers and authored multiple research reports on pesticide health risk assessments and mitigation measures. He also received three Superior Accomplish Awards from the California EPA in recognition of his exceptional contributions and services to State Government.

Panel Experience: 
Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) Scientific Advisory Panel meetings: Physiologically-based Pharmacokinetic Modeling (2017); and Proposed Guidelines for Efficacy Testing of Topically Applied Pesticides Used Against Certain Ectoparasitic Pests on Pets (2019)

                           Judy Sue LaKind, MS, PhD
                                       
Affiliation:
President, LaKind Associates, LLC, Catonsville, Maryland

Expertise: 
Exposure science; Human health risk assessment; Biomonitoring; Scientific and technical analysis for regulatory support; State-of-the-science and systematic reviews

Education: 
PhD in Geography and Environmental Engineering, The Johns Hopkins University; MS in Geology, The University of Wisconsin, Madison; BA in Earth and Planetary Sciences, The Johns Hopkins University

Experience Summary: 
Dr. Judy S. LaKind is President of LaKind Associates, LLC, and Adjunct Associate Professor, Department of Epidemiology and Public Health, University of Maryland School of Medicine. She has 35 years of experience as a health and environmental scientist with expertise in exposure science, assessment of human health risks, biomonitoring, scientific and technical analysis for regulatory support, and state-of-the-science and systematic reviews. She serves on the editorial boards of the Journal of Toxicology and Environmental Health (1992-present), Environment International (2013-present), the International Journal of Environmental Research and Public Health (2022-present), and Environmental Toxicology and Chemistry (1996-1998) and is past Associate Editor for the Journal of Exposure Science and Environmental Epidemiology (2008-2014). Dr. LaKind has organized and participated in numerous workshops including the Technical Workshop on Optimizing the Design and Interpretation of Epidemiologic Studies for Assessing Neurodevelopmental Effects from In Utero Chemical Exposure (2005), and the First and Second Technical Workshops on Human Milk Surveillance and Biomonitoring Research on Environmental Chemicals in the United States (2002, 2004). Her primary research interests are on children's exposure assessments, the impact of data quality on risk assessment and systematic review

Panel Experience: 
Health Effects-Energy Research Committee (2017-present), Institute of Medicine Committee on Blue Water Navy Vietnam Veterans and Agent Orange Exposure (2010 - 2011); World Health Organization Survey Coordinating Committee for the WHO Global Survey of Human Milk for Persistent Organic Pollutants (2004-); USEPA Grant Review Panel (2020); Review Panel, National Cancer Institute (NCI) Laboratory of Metabolism (LM) Intramural Program (2015); USEPA Science Advisory Board Panel on Perchlorate - Approaches for Deriving Maximum Contaminant Level Goals for Drinking Water (2012); Food and Drug Administration/Center for Food Safety and Applied Nutrition /Versar, Inc., Peer Consultation on Biomonitoring Data and Reverse Dosimetry to Estimate Chemical Exposures (2021); National Institute of Environmental Health Sciences (NIEHS) Superfund Basic Research and Training Program Grant Proposal Review (2009); NIEHS R21 Research to Action: Assessing and Addressing Community Exposures to Environmental Contaminants (2009)
                   Devon C. Payne-Sturges, DrPH, MPH, MEngr

Affiliation:
Associate Professor, School of Public Health, University of Maryland (UMD), College Park, Maryland

Expertise: 
Expertise is in racial and economic disparities in exposures to environmental contaminants and associated health risks; Children's environmental health; Cumulative risk assessment and environmental health policy.

Education: 
DrPH and MPH in Environmental Health Sciences from Johns Hopkins University Bloomberg School of Public Health; MEngr in environmental engineering and BS in civil engineering from University of Virginia

Experience Summary: 
Dr. Devon Payne-Sturges is an Associate Professor with the Maryland Institute for Applied Environmental Health in the Department of Epidemiology and Biostatistics at the School of Public Health, University of Maryland, College Park, and has more than 20 years of experience in environmental health research and policy reform. Dr.Payne-Sturges was a Fulbright Specialist in Germany during fall semester of 2017 and currently serves on the Board of Scientific Counselors for the National Toxicology Program (2021-present) and as the Inaugural Co-Chair of the Anti-Racism Task Force for the International Society for Environmental Epidemiology (2020 - present). Prior to joining UMD, Dr. Payne-Sturges worked at EPA for 12 years (2002- 2014), including 6 years (2008  -  2014) as Assistant Center Director for Human Health, with EPA's National Center for Environmental Research. Her research focuses on racial and economic disparities in exposures to environmental contaminants and associated health risks with the aim of improving the science used to make decisions about environmental policies that impact the health of communities and populations, especially vulnerable, low income and minority populations.

Panel Experience: 
Board of Scientific Counselors for the National Toxicology Program (2021 - present); Board of Scientific Counselors for the National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (2016-2019); National Academy of Sciences Environmental Health Matters Initiative (EHMI) Standing Committee (2019 - present); NIH Neurological, Aging and Musculoskeletal Epidemiology Study Section (2021); and Peer Review Panel for EPA's draft Planning and Scoping Guidelines for Cumulative Risk Assessment (June 2021)

                              Paul S. Price, PhD
                                       
Affiliation:
Retired USEPA, Part time consultant at Risk Sciences International, Cedar Rapids, Iowa

Expertise: 
Characterizing aggregate and cumulative exposures using biomonitoring and exposure simulation modeling; Assessing risks from combined exposures using PBPK and PBPD models

Education: 
PhD in Toxicology and Environmental Health, Utrecht University; MS in Civil Engineering, University of Maryland; Diploma in Christian Studies, Regent College; BA in Chemistry, University of Maryland; AA in Physical Science, Anne Arundel Community College

Experience Summary: 
Dr. Paul Price is the author of more than 80 papers and book chapters and contributed to the 2019 USEPA "Guidelines for Exposure Assessment" and the Organisation for Economic Co-operation and Development (OECD) report "Considerations for Assessing Risks of Combined Exposure to Multiple Chemicals." Dr. Price has worked for a wide range of organizations including, trade associations (i.e., American Petroleum Institute), state and federal governments (USEPA and the State of Maryland), consulting companies (i.e., AMEC and Ogden), large chemical manufactures (i.e., WR Grace and Dow Chemical), and non-profit organizations (The LifeLine Group). He retired from the USEPA in June of this year and consults part-time with the firm Risk Sciences International. Areas of research includes the integration of mechanistic toxicity and exposure data into chemical risk assessments, modelling chemical exposures from the use of multiple consumer products, determination of variation in aggregate and cumulative exposures from near- and far-field sources using probabilistic models. His publications have won Society of Toxicology awards for the outstanding paper in the field of biological modeling in 2012 and 2019 and the outstanding paper in the field of risk assessment in 1997 and 2016.

Panel Experience: 
European Food Safety Authority, MIXTOX working group (ongoing); Organisation for Economic Co-operation and Development, Work group on cumulative exposures to chemicals (2015-2018); Technical Advisory Committee member EuroMix Project. (2016-2018); Cumulative and Aggregate Risk Evaluation System (CARES)  technical advisory committee (2016-2017); International Life Sciences Institute (ILSI)- Health and Environmental Sciences Institute (HESI) work group on Thresholds of Toxicological Concern (TTC) and antimicrobial chemicals (2014-2017); ILSI-HESI workgroup on mixtures, synergy, use of the TTC (2008-2010); EPA-ACE external peer review of the HARS risk assessment (2002-2003); EPA external peer review of RAGS guidance on the use of probabilistic models (2000); TERA External peer reviewer of site-specific mercury reference dose (1997); EPA External peer reviewer of PCB carcinogenic potency assessment (1996); and State of California risk assessment advisory committee (1996-1997)

                          Cynthia V. Rider, PhD, DABT
                                       
Affiliation:
Toxicologist, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina

Expertise: 
Mixtures toxicology

Education: 
PhD in Environmental Toxicology, North Carolina State University; BS in Biology and Environmental Studies, Tulane University

Experience Summary: 
Dr. Cynthia Rider is a toxicologist in the Systems Toxicology Branch of the Division of Translational Toxicology (DTT) at the National Institute of Environmental Health Sciences (NIEHS) with 17 years of experience in mixtures toxicology. She co-chairs the Botanical Safety Consortium, a public-private partnership aimed at enhancing the toolkit for assessing complex botanical mixtures. She served as a Society of Toxicology Councilor (2019-2022). She has organized multiple workshops (e.g., Advancing Research on Mixtures: New Perspectives and Approaches for Predicting Adverse Human Health Effects (2011), Addressing Challenges in the Assessment of Botanical Dietary Supplement Safety (2016)). She is on the editorial board for Toxicology and the International Journal of Environmental Research and Public Health. Her primary research interest is in better understanding the health effects of chemical mixtures.

Panel Experience: 
International Life Sciences Institute (ILSI Europe panel) on "Building Cumulative Assessment Groups for Combined Exposure Risk Assessment based on the Thresholds of Toxicological Concern (TTC) or Read-across" (2022-present); World Health Organization (WHO) initiative to update the 2005 WHO toxic equivalency factors for dioxin and dioxin-like compounds (2022-present); Environmental Protection Agency (EPA) Request for Applications on "Development of Innovative Approaches to Assess the Toxicity of Chemical Mixtures" (2022); EPA "Systemic Evidence Map for Noncancer Health Effects of Polychlorinated Biphenyl Mixtures" (2022); "Mixture Similarity Tool User Guide" (2021); and "Advances in Dose Addition for Chemical Mixtures: A White Paper" (2020); US Pharmacopeia Green Tea Hepatotoxicity Working Group (2017-2019); European Commission Joint Research Council Workshop on "Advancing the Assessment of Chemical Mixtures and their Risks for Human Health and the Environment" (2018); ATSDR "Guidance Manual for Assessing Health Impacts of Multiple Chemicals and Other Stressors" (2015-2017); She served on the panel for the EPA "Peer Consultation Workshop on the Cumulative Risk Assessment of Phthalates" (2010)

                             Rita S. Schoeny, PhD
                                       
Affiliation:
Rita Schoeny LLC, sole owner, Washington, District of Columbia

Expertise: 
Human Health Risk Assessment; Genetic Toxicology; Toxicology of Chemical Mixtures; Mode of Action /Adverse Outcome Pathways; Frameworks for Risk Assessment in Support of Risk Management; Regulatory Toxicology

Education: 
Postdoctoral Fellowship in Environmental Health, Department of Environmental Health, Kettering Laboratory, University of Cincinnati; PhD in Microbiology, University of Cincinnati; BS in Biology, University of Dayton

Experience Summary: 
Dr. Rita Schoeny retired from USEPA in 2015 after 30 years and is currently a consultant in risk assessment and science policy. Dr. Schoeny's recent positions at USEPA were Senior Science Advisor, Office of Science Policy, Office of Research and Development (2012-2015); Director Risk Assessment Forum, Office of the Science Advisor (2014-2015), Senior Science Advisor Office of Water  (2003-12). Dr. Schoeny has held adjunct graduate school appointments, lectures and trains risk assessment, science policy and toxicology worldwide. She was responsible for major assessments and programs in support of the Safe Drinking Water Act, Clean Water Act, Clean Air Act, and Food Quality Protection Act. Areas of publication include toxicity of PCBs, PAHs, mercury, and drinking water contaminants including DBPs and microbes; environmental mixtures; principles and practice of human health risk assessment. Recent work includes frameworks for human health risk assessment, interpretation of DNA adduct data, episodic and less-than-lifetime exposure to carcinogens, improved dose response assessment, OECD guidelines for genetic toxicity testing, quantitative approaches to genetic toxicology, Adverse Outcome Pathways and Mode of Action, and improved approaches to hazard identification. Dr. Schoeny served on various WHO committees and a NAS committee on risk assessment of complex mixtures. Dr. Schoeny is the recipient of numerous awards including USEPA's Science Achievement Award and is a fellow of the Society for Risk Analysis. Dr. Schoeny provided public comments on recent TSCA assessments. Dr. Schoeny was on the Editorial Board and a reviewer for Regulatory Toxicology and Pharmacology (2015 - 2021). Dr. Schoeny also served as a reviewer for Mutation Research, Risk Analysis, Environmental Mutagenesis, Critical Reviews in Toxicology, Environmental and Molecular Mutagenesis, Environmental Health Perspectives, others (1984 - present). Dr. Schoeny's experience includes review formats including modified Delphi, panel reviews with and without in-person meetings, written reviews with and without opportunity for revision, and consensus reviews.

Panel Experience: 
Internal peer review of 100 or more USEPA documents, manuscripts, regulations (1985-2015); Reviewer in multiple Food and Drug Administration (FDA) and Agency for Toxic Substances and Disease Registry (ATSDR)documents (2003 - 2015); Reviewer of multiple International Programme on Chemical Safety (IPCS) documents (1990 - 2015); Reviewer USEPA research grants (2000 - 2015); Several review panels for SciPinion (2017 - present); Health Canada review panels (2017, 2023); Texas Commission on Environmental Quality cancer risk assessment on ethylene oxide (2020); World Health Organization Adverse Outcome Pathway wiki reviewer, several (2017 -2021); Reviewer for Alliance for Risk Assessment case studies (2014-2016, 2019, 2022); Emergency use drug approval, FDA (2021) 

                              Jennifer Seed, PhD
                                       
Affiliation:
Independent Consultant, Alexandria, Virginia (retired from USEPA)

Expertise: 
Regulatory toxicology; Risk assessment; Science policy; Testing strategies; and Mode of action analyses

Education: 
PhD in Developmental and Cellular Biology, University of Washington; BA in Anthropology (Biology), University of Washington

Experience Summary: 
Dr. Jennifer Seed has over 35 years of experience in toxicology and risk assessment. She held positions in the Office of Pollution Prevention and Toxics, USEPA for 23 years as Developmental and Reproductive Toxicologist (1989-1994), Branch Chief (1997-2009), Deputy Division Director (2009-2013), and Senior Science Advisor (2013-2014). Dr. Seed was a member of the Risk Assessment Forum for over 10 years and was involved in many domestic and international risk assessment activities including the development of the Developmental and Reproductive Test and Risk Assessment Guidelines; the Food Quality Protection Act Uncertainty Factor Policy; the Cancer Risk Assessment Guidelines; the Mixtures Guideline; the Genomics White Paper; the Endocrine Nonmonotonic Dose Response White Paper and the review of the RfD/RfC process. She has been a key player in the development of the World Health Organization Mode of Action/Human Relevance Framework and taught the Framework to scientists worldwide. Dr. Seed served on many USEPA and OECD panels while employed at the USEPA, and the documents were then provided to external peer review panels. Dr. Seed retired from the USEPA in 2014 and currently serves as an independent consultant.

Panel Experience: 
Several peer review panels established by SciPinion including: immunotoxicology of PFAS (2022); grouping of PFAS for human health risk assessment (2021-2022); evaluation of reproductive toxicity studies and data interpretation of N-methylpyrrolidone for risk assessment (2021-2022)

                            R. Woodrow Setzer, PhD
                                       
Affiliation:
Retired, previously with USEPA, Office of Research and Development (ORD), Center for Computational Toxicology and Exposure (CCTE), Research Triangle Park, North Carolina

Expertise: 
Statistics and study design in field and laboratory in vivo and in vitro studies for dose-response analysis; Parameter estimation and uncertainty analysis in PBTK and other mechanistic models; Dose/concentration-response analysis for cumulative risk assessments; Modeling of biological systems 

Education: 
PhD in Ecology and Evolution, SUNY Stony Brook; BA in Mathematics, The University of Chicago; Postdoctoral Training: Postdoctoral Fellow, Department of Biostatistics, School of Public Health, UNC, Chapel Hill; National Research Council (NRC) Associate, Health Effects Research Laboratory, USEPA

Experience Summary: 
Dr. R. Woodrow Setzer is a biostatistician and worked in the Office of Research and Development at USEPA before he retired after over 29 years. He also held appointments as an adjunct associate professor in the Department of Biostatistics in the University of North Carolina-Chapel Hill, School of public health (2000-2010) and as an adjunct assistant professor in the Department of Statistics of NC State University (2007-2013). He was an associate editor for the Journal of Statistical Software (2007-2015) and served on the editorial boards of Toxicology Methods (1992-1997) and Human and Ecological Risk Assessment (2011-2014). He chaired USEPA's Risk Assessment Forum's Panel developing the Benchmark Dose Technical Guidance Document (1998-2005), co-organized and co-chaired the workshop PBPK/PD Models for Cumulative Risk (2003), co-chaired the International Workshop on Uncertainty and Variability in PBPK Models (2006-2007). Dr. Setzer also participated in the International Program on Chemical Safety (IPCS) Authors' Workshop on Dose-Response Modeling (Geneva, 2004), the European Food Safety Authority/World Health Organization International Conference Risk Assessment of Compounds that are both Genotoxic and Carcinogenic (Brussels, 2005), the International Life Sciences Institute (ILSI)-Europe Expert Group on the Application of the Margin of Exposure Approach to Genotoxic Carcinogens in Food (2006-2009), and the WHO International Workshop on Principles of Characterizing and Applying PBPK Models in Risk Assessment (Berlin, 2009). In addition, he has participated as a presenter to several sessions of the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA SAP) supporting EPA's cumulative risk assessments for organophosphate pesticides, carbamates, and pyrethroids. His research interests include developing, evaluating, and applying statistical methodology for human health effects risk analysis, including benchmark dose methods and dose-response methods for high-throughput screening assays.

Panel Experience: 

National Toxicology Program/Center for the Evaluation of Risks to Human Reproduction panel on the reproductive and developmental toxicity of styrene (2005); Scientific Workshop to inform USEPA's Response to National Academy of Science Comments on the Health Effects of Dioxin in USEPA's 2003 Dioxin Reassessment (2009)

                    Robert S. Skoglund PhD, DABT, CIH, CPPS
                                       
Affiliation:
Head of Product Safety and Regulatory Affairs for Covestro LLC in Pittsburgh, Pennsylvania

Expertise: 
Toxicology, Ecotoxicology, Environmental chemistry, and Risk assessment

Education: 
PhD in Environmental Chemistry from the University of Minnesota School of Public Health and MS in Toxicology, University of Minnesota

Experience Summary: 
Dr. Robert Skoglund has over 35 years of experience in the Environment, Health, and Safety (EHS) field including chemical safety, global chemical management regulations, stewardship, and sustainability. Dr. Skoglund serves as an adjunct professor in the Schools of Public Health at the University of Minnesota and Indiana University; has served as an advisor to the Occupational Safety and Health Administration, the Environmental Protection Agency, the National Institute of Environmental Health Sciences, the National Academy of Sciences, the European Chemicals Agency; and on the editorial board of the journal Toxicology and Industrial Health.

Panel Experience: 
USEPA Science Advisory Board's, Chemical Assessment Advisory Committee (2012-2018)

                             Sonya K. Sobrian, PhD
                                       
Affiliation:
Associate Professor, Department of Pharmacology, Howard University College of Medicine, Washington, District of Columbia

Expertise: 
Developmental Neuropharmacology and Neurotoxicity 

Education: 
PhD in Physiological Psychology, Carleton University, Ottawa Canada; MA in Neuropharmacology, Ottawa University, Canada

Experience Summary: 
Dr. Sonya K. Sobrian is an Associate Professor of Pharmacology at the Howard University College of Medicine, Director of the Developmental Neurobehavioral Pharmacology Laboratory, and Past Chair of the University's Institutional Animal Care and Use Committee (IACUC).   Dr. Sobrian was a postdoctoral fellowship at Princeton University in Developmental Neurobiology.  She also added pharmacology and immunology to her graduate (MA, Neuropharmacology, Ottawa University) and post-graduate (Fulbright Fellow: Immunology Research Center, Belgrade, Yugoslavia) training.  The major focus of her research involves the behavioral, immunological and neurotoxicological consequences of prenatal/developmental exposure to stress, environmental toxicants, and drugs of abuse. She has a longstanding interest in sex differences, and her lab was the first to show that prenatal environmental and psychological stress deferentially altered immune parameters in rat male and female offspring, research that she continued as a Fulbright Scholar at the Immunological Research Institute in Belgrade, Yugoslavia. Previous research has focused on the life-span consequences of prenatal exposure to cocaine and nicotine, alone and in combination, with an emphasis on drug addiction in the aging organism. As a visiting scientist at the National Center for Toxicological Research, in Arkansas, Dr. Sobrian was instrumental in establishing a prenatal model of cocaine toxicity. Dr. Sobrian is also exploring the role of prenatal environmental noise stress (PENS) in the etiology of autism and depression. Currently her research involves the multi- and trans-generational inheritance of addiction-like behaviors following prenatal exposure to synthetic cannabinoids. Dr. Sobrian has served as Director of the Behavioral Neuroscience Program at the National Science Foundation, and Chair of the Board of Trustees of the Association for Assessment and Accreditation of Laboratory Animal Care International. She has been President of the Developmental Neurotoxicology Society (formerly Neurobehavioral Teratology Society), and currently serves as Section Editor for Developmental Toxicology of that society's scientific journal, Neurotoxicology and Teratology. Dr. Sobrian was formerly on the Board of Scientific Counselors for the Department of Health & Human Services National Toxicology Program, and currently is a member of the External Advisory Committee of the NIH-funded Toxicology Mentoring and Skills Development Training Program. 

Panel Experience: 
Numerous Federal Insecticide, Fungicide, and Rodenticide Act Science Advisory Panels including: Chlorpyrifos-Analysis of Biomonitoring Data (2016); Evaluation of the Common Mechanism of Action of Pyrethroid Pesticides; Peer Review of Continuing Development of Alternative High-Throughput Screens to Determine Endocrine Disruption, Focusing on Androgen Receptor, Steroidogenesis, and Thyroid Pathways (2017); Review of A Set of Scientific Issues Being Evaluated by the Environmental Protection Agency Regarding USEPA's Evaluation of the Carcinogenic Potential of Glyphosate (2016); Human Health and Ecological Risk Assessments for SmartStax PRO (2016); Comparative Toxicity Sensitivity of Adults and Juveniles to Pyrethroids (2010); Past member of the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (2016-2019) 
 

                             Daniel J. Spade, PhD
                                       
Affiliation:
Assistant Professor of Pathology and Laboratory Medicine at Brown University, Providence, Rhode Island

Expertise: 
Reproductive and developmental toxicology focusing on fetal testis development; Mechanisms of phthalate toxicity; and Roles of sperm RNA in reproduction

Education: 
PhD in Veterinary Medical Sciences (Toxicology concentration), University of Florida; BS in Biology, The Pennsylvania State University

Experience Summary: 
Dr. Daniel Spade is an Assistant Professor in the Department of Pathology and Laboratory Medicine at Brown University. He has 15 years of research experience in reproductive toxicology, and he teaches an undergraduate/graduate toxicology course. His current research focus includes the mechanisms by which phthalates alter fetal testis development, and development of sperm RNA markers of male infertility and reproductive toxicity. Prior research focused on reproductive and endocrine effects of metals and organochlorine pesticides in aquatic and marine animals. He is a member of the Society of Toxicology (2011-present), where he has served as New Career Councilor of the Reproductive and Developmental Toxicology Specialty Section; the American Society of Andrology (2017-present), where he currently serves as the Chair of the Constitution and Bylaws Committee; and the Society of Environmental Toxicology and Chemistry (2008-present).

Panel Experience: 
National Toxicology Program (NTP) Expert Panels for Peer Review of the Draft NTP Developmental and Reproductive Toxicity Technical Report on the Modified One-Generation Study of Bisphenol AF (2022); Peer Review of the Draft NTP Technical Reports on the Toxicology and Carcinogenesis Studies of Sodium Tungstate Dihydrate, Di-n-butyl Phthalate, and Di(2-ethylhexyl) Phthalate (2021); NIH Scientific Review Groups ZES1 LAT-S (SF) 1: Superfund Working Group Phase I and II (2021), ZES1 JAB-D (SF): P42 Superfund Grant Applications (2019), and ZES1 JAB-D (R1): R01 ViCTER Environmental Research Grant Applications (2019); and Agence Nationale de la Recherche (France) Evaluation Panel CE34  -  Contaminants, Ecosystems and Health (2022)

                          Shirlee, Wei-Ling, Tan, PhD
                                       
Affiliation:
Senior Toxicologist, Public Health Department for Seattle & King County, Washington

Expertise: 
Cell and Molecular Biology (NAMs, EDCs); Toxicology (Human Health, Public Health); Equity and Social Justice (Cumulative Exposures and Disparities); Dopaminergic receptors and neurodegenerative pathways

Education: 
PhD in Biology, University of California, San Diego (in coordination with the Salk Institute for Biological Sciences); BS, Duke University

Experience Summary: 
Dr. Shirlee Tan is the Senior Toxicologist for the Seattle & King County Public Health Department where she serves as a technical advisor for the department on risks related to chemical exposures, health outcomes, and policies. Dr. Tan has worked for 22 years on regulatory assay development for chemicals, and more recently at the community, local, state, and national levels on science policy and actions around chemical exposures and effects. Dr. Tan serves on numerous advisory groups for Washington State on chemical policies, toxics cleanup, and environmental justice (2017-present). She is the incoming Chair of USEPA's Children's Health Protection Advisory Committee (CHPAC) (2020-2026). Dr. Tan previously worked for the Organization for Economic Cooperation and Development (OECD, 2010-2011) and the USEPA (2000-2011) on the development of regulatory assays for endocrine disrupting chemicals. She now serves on many OECD advisory and working groups. She worked for the Smithsonian Institution's National Zoological Park on pesticide misuse in Southeast Asia (2002-2008) and consults for the Endocrine Society on issues related to endocrine disrupting chemicals. 

Panel Experience: 
Washington State Chemical Action Plan for PFAS (2016-2018); Washington State Flame Retardant Stakeholder Advisory Committee (2018); Washington State Action Plan for Phthalates (2022-present); Washington State Model Toxics Control Act Stakeholder and Tribal Advisory Committee (2019-present); and the Washington State Environmental Justice Task Force Subcommittee on Community Engagement (2019-2020). USEPA's Children's Health Protection Advisory Committee 2020-2026 (serving as chair starting March 2023-2026); Workshop for the National Academies Committee on Variability and Relevance of Current Laboratory Mammalian Toxicity Tests and Expectations for New Approach Methods (NAMs) for use in Human Health Risk Assessment (May 2022); National Toxicology Program workshop titled Using New Approach Methodologies to Address Variability and Susceptibility Across Populations (October 2022); National Academies Children's Environmental Health Workshop session on Balancing Prevention and Uncertainty (August 2022); International: OECD Groups (2016-present) Advisory Group on Endocrine Disruptor Testing and Assessment; Working Party for Hazard Assessment; Expert Group for Molecular Screening and Toxicogenomics

                              Daniele Wikoff, PhD
                                       
Affiliation:
Principal and Practice Director at ToxStrategies, Asheville, North Carolina

Expertise: 
Toxicology; Risk assessment; Systematic Review; Peer-Review

Education: 
PhD in Toxicology, University of North Carolina at Chapel Hill; BS in Chemistry and Biology, Buena Vista University, Iowa

Experience Summary: 
Dr. Daniele Wikoff's more than 15 years of consulting experience as a practitioner of both risk assessment and systematic review allows for a unique area of expertise in the evolving field of evidence-based toxicology. As the Health Sciences Practice Director, she has successfully implemented a turn-key process for conducting systematic assessments with a workflow facilitated by the combination of a multidisciplinary team and use of systematic review software and tools. Dr. Wikoff is a contributing author to the World Health Organization (WHO) Systematic Review Framework for Chemical Risk Assessment and is well-versed in both risk assessment and systematic review frameworks and guidance from authorities around the world. Dr. Wikoff serves as an Associate Editor for Toxicological Sciences, Regulatory Toxicology and Pharmacology, and Current Opinions in Toxicology. She routinely provides guest lectures and presents in Continuing Education courses and has led and/or participated in numerous workshops in the area of systematic review and risk assessment. Her research interests include methods development related to the definition and evaluation of data quality, and how elements of internal, construct, and external validity can be used to transparently inform conclusions and provide critical information to decision makers. Dr. Wikoff is involved in a number of global collaborations to advance the practice of evidence-based toxicology, highlighted by her membership on the Board of Trustees for the Evidence-Based Toxicology Collaboration, as well as Chair of the Science Advisory Council in which the primary role involves committee-style peer review of systematic review related projects (2018-present).

Panel Experience: 

Member, Scientific Program Committee for the Society of Toxicology; Member for the National Academies of Science committee on the review of the Integrated Risk Information System (IRIS) Protocol for Inorganic Arsenic; Scientific Quality Reviewer for the U.S. Department of Agriculture, a reviewer for the National Institute of Environmental Health Sciences -- Virtual Consortium for Translational/Transdisciplinary Environmental Research, and expert reviewer for Health Canada as part of the Review of Biomonitoring Equivalents: Derivation of Biomonitoring Equivalents for Pentabromodiphenylether (PBDE-99), as well as on an EPA External Review Panel -- An Exposure Assessment of Polybrominated Diphenyl Ethers 

                     Douglas C. Wolf, DVM, PhD, FIATP, ATS
                                       
Affiliation:
Senior Fellow, Syngenta Crop Protection, Greensboro, North Carolina

Expertise: 
Toxicology; Toxicologic Pathology; Pathology; Veterinary Medicine

Education: 
DVM, University of Missouri; PhD in Veterinary Pathology, Purdue University 

Experience Summary: 
Dr. Douglas Wolf graduated in 1981 from the University of Missouri with a Doctor of Veterinary Medicine degree and, after 6 years in clinical veterinary practice, attended Purdue University where, in 1991, he completed a pathology residency and PhD in Veterinary Pathology. Dr. Wolf was a staff scientist for 6 years at the Chemical Industry Institute of Toxicology where he studied chemical carcinogenesis. From 1997 until 2013. Dr. Wolf held various research and leadership positions with the USEPA, where he continued research in chemical carcinogenesis and molecular pathology. In November 2013, he joined Syngenta Crop Protection and is currently a Senior Syngenta Fellow where he leads international efforts to advance the science of risk assessment focusing on crop protection chemicals. Dr. Wolf has authored or coauthored over 155 journal articles, book chapters, and technical reports and is a Fellow of the International Academy of Toxicologic Pathologists and the Academy of Toxicological Sciences. Dr. Wolf is on the Editorial Board and an Associate Editor of Toxicologic Pathology (1998-2004). Dr. Wolf has been a member of the Executive Committee of the Society of Toxicologic Pathology (2015-17) and the Executive Committee and the Board of Trustees of the Health and Environmental Sciences Institute (2019-Present).

Panel Experience: 

Pathology Working Groups National Toxicology Program (23, 1991-2008); The Copernicus Group Institutional Review Board (IRB) (1996-2000); Center for Disease Control and Prevention (CDC)/ National Institute for Occupational Safety & Health (NIOSH) Program Review (1998); Ethylene Glycol Review Health Canada (2001); Health Advisory Board NSF-International (2020-present)

                             Ami R. Zota, ScD, MS
Affiliation:
Associate Professor, Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York
Expertise: 
Exposure Science; Biomonitoring; Reproductive and Environmental Epidemiology; Maternal and Child Health; Environmental Justice; Health Disparities
Education: 
Doctor of Science, Harvard T.H. Chan School of Public Health; Master of Science, Harvard T.H. Chan School of Public Health; Bachelor of Science in Public Health, University of North Carolina at Chapel Hill 
Experience Summary: 
Dr. Ami Zota is an Associate Professor and population health scientist at Columbia University Mailman School of Public Health. Her scientific research focuses on the health disparities associated with exposure to toxic chemicals, including phthalates. Dr. Zota is an internationally recognized expert in environmental health science and environmental justice with specific expertise in exposure assessment, biomonitoring, epidemiology, health disparities, and maternal and reproductive health. She has spent more than 16 years researching exposures to and health outcomes associated with phthalates and other toxic chemicals and has authored or coauthored more than 60 peer-reviewed scientific publications. Dr. Zota is the founding director of the Agents of Change in Environmental Justice program, which seeks to empower emerging leaders from historically excluded backgrounds in science and academia to reimagine solutions for a just and healthy planet by providing applied training in science communication, leadership, and public engagement with science. She is currently an Associate Editor at Environmental Health Perspectives and Environmental Justice. From 2017-2022, she was an Associate Editor at the Journal of Exposure Science and Environmental Epidemiology.
Panel Experience: 
Standing member of the Social and Environmental Determinants of Health National Institutes of Health (NIH) Center for Scientific Review (CSR) Study Section (current); Standing member of the Infectious Disease, Reproductive Health, Asthma, and Pulmonary Conditions (IRAP) NIH CSR Study Section (2021-2022); Temporary, ad hoc member of 7 different NIH CSR Study Sections (2017-2021); Research Solicitations for USEPA National Priorities: Per- and Polyfluorinated Substances (2018)