Document ID: EPA-HQ-OPP-2006-0038-0004
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2006-02-15T05:00Z

Page
1
of
21
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES,
AND
TOXIC
SUBSTANCES
MEMORANDUM
Date:
November
18,
2005
Subject:
Triadimenol.
Acute
and
Chronic
Dietary
Exposure
Assessments
for
the
Tolerance
Reassessment
Eligibility
Decision
(
TRED)
Document.

DP
Barcode:
D314928
PC
Code:
127201
40
CFR
§
:
180.450
Chemical
Class:
Azole
From:
Samuel
Ary,
Chemist
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

Through:
Thurston
Morton,
Chemist
David
Soderberg,
Chemist
Dietary
Exposure
Science
Advisory
Council
(
DESAC)
Health
Effects
Division
(
7509C)

William
Hazel,
Branch
Chief
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

To:
Richard
Griffin,
Risk
Assessor
Christina
Jarvis,
Risk
Assessor
Reregistration
Branch
II
Health
Effects
Division
(
7509C)

John
Pates,
Chemical
Review
Manager
Reregistration
Branch
I
Special
Review
and
Reregistration
Division
(
7508C)
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
Page
2
of
21
Executive
Summary
Acute
and
chronic
dietary
(
food
and
water)
exposure
assessments
were
conducted
using
the
Dietary
Exposure
Evaluation
Model
software
with
the
Food
Commodity
Intake
Database
(
DEEM­
FCID
 
,
Version
2.03),
which
uses
food
consumption
data
from
the
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII)
from
1994­
1996
and
1998.
The
acute
and
chronic
dietary
risk
assessments
were
conducted
for
all
supported
triadimenol
food
uses
and
were
performed
to
support
the
tolerance
reassessment
eligibility
decision
document.

Triadimenol,
$­(
4­
chlorophenoxy)­"­(
1,1­
dimethylethyl)­
1H­
1,2,4­
triazole­
1­
ethanol,
is
a
systemic
fungicide
registered
for
use
in
the
United
States
as
a
seed
treatment
for
barley,
corn,
cotton,
oats,
rye,
and
wheat.
Additionally,
an
import
tolerance
on
bananas
has
been
established.
Triadimenol
end­
use
products
are
marketed
in
the
U.
S.
under
the
trade
name
Baytan
®
.
The
reregistration
of
triadimenol
is
being
supported
by
Bayer
CropScience,
the
basic
producer.

Acute
Dietary
Exposure
Results
and
Characterization
of
Input
Data
A
refined
acute
dietary
exposure
assessment
was
conducted
to
estimate
the
dietary
risks
associated
with
the
reregistration
of
triadimenol.
The
acute
dietary
exposure
assessment
incorporated
a
DEEM
Version
7.81
default
processing
factor
for
dried
bananas
along
with
the
available
data
from
the
processing
studies
and
100%
crop
treated.
The
anticipated
residue
(
AR)
estimate
for
bananas
is
based
on
the
available
field
trial
data
while
incorporating
existing
tolerance
values
for
the
remaining
commodities.
The
assessment
also
included
the
peak
surface
water
concentration.
Acute
dietary
risk
estimates
are
provided
for
the
general
U.
S.
population
and
various
population
subgroups,
with
the
major
emphasis
placed
on
the
exposure
estimates
for
infants
and
children.
This
assessment
concludes
that
for
all
supported
commodities,
the
acute
dietary
risk
estimates
do
not
exceed
HED's
level
of
concern
(
less
than
100%
of
the
aPAD)
at
the
95th
exposure
percentile
for
the
U.
S.
population
(
15%
of
the
aPAD)
and
all
population
subgroups,
with
the
highest
exposed
population
subgroup
being
children
1­
2
years
old
at
29%
of
the
aPAD.

Chronic
Dietary
Exposure
Results
and
Characterization
of
Input
Data
A
conservative
chronic
dietary
exposure
assessment
was
conducted
to
estimate
the
dietary
risks
associated
with
the
reregistration
of
triadimenol.
The
chronic
dietary
exposure
assessment
incorporated
a
DEEM
Version
7.81
default
processing
factor
for
dried
bananas
along
with
the
available
data
from
the
processing
studies.
Existing
tolerance
level
residues,
100%
crop
treated,
and
the
highest
1
in
10
year
annual
mean
drinking
water
concentration
were
used
to
conduct
this
conservative
assessment.
Chronic
dietary
risk
estimates
are
provided
for
the
general
U.
S.
population
and
various
population
subgroups,
with
the
major
emphasis
placed
on
the
exposure
estimates
for
infants
and
children.
This
assessment
concludes
that
for
all
supported
commodities,
the
chronic
dietary
risk
estimates
do
not
exceed
HED's
level
of
concern
(
less
than
100%
of
the
cPAD)
for
the
U.
S.
population
(
7%
of
the
cPAD)
and
all
population
subgroups,
with
the
highest
exposed
population
subgroup
being
children
1­
2
years
old
at
23%
of
the
cPAD.

Aggregate
Exposure
to
Triadimefon
and
Triadimenol
Exposure
to
triadimenol
can
occur
following
the
application
of
triadimenol
as
an
active
ingredient
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
Page
3
of
21
as
well
as
from
the
metabolism/
degradation
of
triadimefon.
The
current
dietary
risk
assessment
only
addresses
the
use
of
triadimenol
as
an
active
ingredient
per
se.
Exposures
from
the
pesticidal
uses
of
triadimenol
have
not
been
aggregated
with
triadimenol
exposures
reflecting
metabolism
and/
or
degradation
of
triadimefon
because
risks
attributable
to
uses
of
triadimefon
already
exceed
HED's
level
of
concern
(
S.
Ary,
D314778,
11/
23/
2005)
and
because
the
resulting
apparent
increase
in
aggregate
risk
would
unduly
be
associated
with
the
registered
uses
of
triadimenol.
The
Agency
is
soliciting
comments
on
assumptions
used
in
the
current
risk
assessment.
Should
refinements
be
possible
in
the
future,
it
may
be
appropriate
to
aggregate
multiple
routes
and
sources
of
exposures
for
these
chemicals.

I.
Introduction
Dietary
risk
assessment
incorporates
both
exposure
and
toxicity
of
a
given
pesticide.
For
acute
and
chronic
assessments,
the
risk
is
expressed
as
a
percentage
of
a
maximum
acceptable
dose
(
i.
e.,
the
dose
which
the
Health
Effects
Division
has
concluded
will
result
in
no
unreasonable
adverse
health
effects).
This
dose
is
referred
to
as
the
population
adjusted
dose
(
PAD).
The
PAD
is
equivalent
to
the
Reference
Dose
(
RfD)
divided
by
the
special
FQPA
Safety
Factor.

For
acute
and
non­
cancer
chronic
exposures,
HED
is
concerned
when
estimated
dietary
risk
exceeds
100%
of
the
PAD.
References
which
discuss
the
acute
and
chronic
dietary
risk
assessments
in
more
detail
are
available
on
the
EPA
pesticides
web
site:
"
Available
Information
on
Assessing
Exposure
from
Pesticides,
A
User's
Guide,"
6/
21/
2000,
web
link:
http://
www.
epa.
gov/
fedrgstr/
EPA­
PEST/
2000/
July/
Day­
12/
6061.
pdf;
or
see
SOP
99.6
(
8/
20/
1999).

II.
Residue
Information
The
reregistration
requirements
for
plant
metabolism
have
not
been
fulfilled.
No
metabolism
studies
with
triadimenol
have
been
submitted,
however,
metabolism
studies
with
triadimefon
have
been
received
and
reviewed.
HED
has
determined
that
translation
of
metabolism
data
from
triadimefon
to
triadimenol
is
not
appropriate
for
the
existing
uses
on
cereal
grains
and
cotton.
The
metabolism
studies
with
triadimefon
were
conducted
using
a
foliar
application
and
triadimenol
is
used
only
as
a
seed
treatment.
Additionally,
in
the
submitted
triadimenol
seed
treatment
wheat
study,
residues
were
not
identifiable
due
to
the
low
activity
found
in
wheat
grain.
Therefore,
HED
concludes
that
the
nature
of
the
residue
in
cereal
grains
is
not
adequately
understood;
however,
based
on
chemical
structure
and
the
probable
metabolic
pathway
of
triadimenol,
the
residues
of
concern
for
tolerance
expression
and
risk
assessment
are
likely
to
be
triadimenol,
KWG
1342,
and
KWG
1732
in/
on
cereal
grains
(
barley,
corn,
oats,
rye,
and
wheat)
and
cotton.
The
wheat
metabolism
data
conducted
with
triadimefon
indicate
that
KWG
1732
is
the
major
metabolite
found
in
grain
at
35%
TRR
and
KWG
1342
at
21%
TRR
in
grain.
Triadimenol
accounted
for
12%
TRR.
It
is
also
noted
that
the
submitted
wheat
processing
study
conducted
with
triadimenol
applied
as
a
seed
treatment
identified
quantifiable
residues
of
KWG
1732.
There
have
been
no
previous
triazole
labeled
studies
conducted
with
triadimenol
applied
as
a
seed
treatment
to
commodities
and
data
from
the
available
soil
metabolism
studies
conducted
with
triadimefon
indicate
that
soil
microbes
metabolize
the
triazole
fungicide
to
free
triazole,
which
may
be
taken
up
into
the
plant.
Separate
metabolism
studies
with
triazole­
14C
and
phenyl­
14C
labeled
triadimenol
applied
as
a
seed
treatment
to
corn
or
wheat
and
cotton
should
be
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
Page
4
of
21
Cl
O
N
N
N
OH
Cl
O
N
N
N
OH
OH
conducted
to
confirm
the
residues
of
concern.

The
residues
of
concern
for
tolerance
expression
and
risk
assessment
for
bananas
are
triadimenol
and
KWG
1342,
which
are
based
on
the
available
metabolism
data
conducted
with
triadimefon
applied
to
an
established
grape
vine
and
the
field
trial
data
conducted
with
triadimenol
applied
to
the
soil
of
banana
groves.
The
metabolism
data
conducted
with
triadimefon
applied
to
grapes
indicate
that
triadimenol
is
the
major
metabolite
identified
at
56%
along
with
KWG
1342
at
16%.
The
available
field
trial
data
indicate
that
residues
of
triadimenol
and
KWG
1342
are
both
likely
to
be
found
in/
on
bananas.

HED
has
determined
that
only
triadimenol
in
drinking
water
should
be
considered
in
the
dietary
risk
assessment;
it
was
the
major
residue
found
in
the
available
triadimefon
aerobic
soil
metabolism
study
(
MRID
41686102).

Triadimenol
is
not
registered
for
use
as
a
direct
livestock
treatment.
The
nature
of
the
residue
in
livestock
is
adequately
defined
for
the
current
uses.
HED
concludes
that
the
supported
uses
on
barley,
corn,
cotton,
oats,
rye,
and
wheat
result
in
a
40
CFR
§
180.6(
a)(
3)
situation
for
ruminant
commodities;
i.
e.,
there
is
no
reasonable
expectation
of
finite
residues
in
ruminant
commodities.
The
structure
of
triadimenol
and
metabolites
of
concern
are
presented
in
Table
1.
Summary
of
the
decisions
concerning
the
residues
of
concern
in
plants
and
drinking
water
are
presented
below
in
Table
2.

Table
1.
Chemical
Names
and
Structures
of
Triadimenol
and
Its
Metabolites.

Common
name
and
chemical
name
Chemical
structure
Triadimenol
(
KWG
0519)

$­(
4­
chlorophenoxy)­"­(
1,1­
dimethylethyl)­
1H­
1,2,4­
triazole­
1­
ethanol
KWG
1342
1­(
4­
chlorophenoxy)­
3,3­
dimethyl­
3­
hydroxymethyl­
1­(
1H­
1,2,4­
triazol­
1­
yl)­
2­
butanol
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
Table
1.
Chemical
Names
and
Structures
of
Triadimenol
and
Its
Metabolites.

Common
name
and
chemical
name
Chemical
structure
Page
5
of
21
Cl
O
N
N
N
O
OH
KWG
1732
1­(
4­
chlorophenoxy)­
1­(
1H­
1,2,4­
triazol­
1­
yl)
ethanoic
acid
Table
2.
Summary
of
Metabolites
and
Degradates
to
be
Included
in
the
Risk
Assessment
and
Tolerance
Expression
for
Triadimenol.

Matrix
Residues
Included
in
Risk
Assessment
Residues
Included
in
Tolerance
Expression
Plants
Primary
crop
­
cereal
grains
and
cotton
triadimenol,
KWG
1342,
and
KWG
1732
triadimenol,
KWG
1342,
and
KWG
1732
Primary
crop
­
banana
triadimenol
and
KWG
1342
triadimenol
and
KWG
1342
Rotational
crop
triadimenol,
KWG
1342,
and
KWG
1732
triadimenol,
KWG
1342,
and
KWG
1732
Livestock
Ruminant
NA
NA
Poultry
NA
NA
Drinking
water
triadimenol
NA
A
summary
of
the
triadimenol
tolerance
reassessment
and
recommended
modifications
in
commodity
definitions
is
presented
in
Table
3
(
S.
Ary,
D314891,
11/
17/
2005).

Table
3.
Tolerance
Reassessment
Summary
for
Triadimenol.

Commodity
Current
Tolerance,
ppm
Reassessed
Tolerance,
ppm
Comment
[
Correct
Commodity
Definition]

Tolerances
Established
Under
40
CFR
§
180.450
(
a)

Banana
(
whole)
1
0.2
0.2
Barley,
grain
0.05
TBD2,3
Barley,
straw
0.2
TBD
Corn,
forage
0.05
TBD
[
Corn,
field,
forage]
[
Corn,
sweet,
forage]

Corn,
fresh
(
including
sweet),
(
K+
CWHR)
0.05
TBD
[
Corn,
sweet,
K+
CWHR]

Corn,
grain
0.05
TBD
[
Corn,
field,
grain]
[
Corn,
pop,
grain]
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
Table
3.
Tolerance
Reassessment
Summary
for
Triadimenol.

Commodity
Current
Tolerance,
ppm
Reassessed
Tolerance,
ppm
Comment
[
Correct
Commodity
Definition]

Page
6
of
21
Corn,
stover
0.05
TBD
[
Corn,
field,
stover]
[
Corn,
pop,
stover]
[
Corn,
sweet,
stover]

Cotton,
forage
0.02
Revoke
No
longer
considered
a
significant
livestock
feed
item.

Cotton,
undelinted
seed
0.02
TBD
Oat,
forage
2.5
TBD
Oat,
grain
0.05
TBD
Oat,
straw
0.2
TBD
Rye,
forage
2.5
TBD
Rye,
grain
0.05
TBD
Rye,
straw
0.1
TBD
Sorghum,
forage,
hay
0.05
Revoke
Bayer
does
not
intend
to
support
use
of
triadimenol
on
sorghum.

Sorghum,
grain
0.01
Revoke
Bayer
does
not
intend
to
support
use
of
triadimenol
on
sorghum.

Sorghum,
grain,
stover
0.01
Revoke
Bayer
does
not
intend
to
support
use
of
triadimenol
on
sorghum.

Wheat,
forage
2.5
TBD
Wheat,
grain
0.05
TBD
Wheat,
straw
0.2
TBD
Tolerances
Established
Under
40
CFR
§
180.450
(
b)

Cattle,
fat
0.1
Revoke
The
available
data
indicate
that
tolerances
for
cattle
commodities
are
not
required.
Cattle,
meat
0.1
Cattle,
meat
byproducts
0.1
Egg
0.01
Revoke
The
available
data
indicate
that
a
tolerance
for
eggs
is
not
required.

Goat,
fat
0.1
Revoke
The
available
data
indicate
that
tolerances
for
goat
commodities
are
not
required.
Goat,
meat
0.1
Goats,
meat
byproducts
0.1
Hog,
fat
0.1
Revoke
The
available
data
indicate
that
tolerances
for
hog
commodities
are
not
required.
Hog,
meat
0.1
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
Table
3.
Tolerance
Reassessment
Summary
for
Triadimenol.

Commodity
Current
Tolerance,
ppm
Reassessed
Tolerance,
ppm
Comment
[
Correct
Commodity
Definition]

Page
7
of
21
Hog,
meat
byproducts
0.1
Horse,
fat
0.1
Revoke
The
available
data
indicate
that
tolerances
for
horse
commodities
are
not
required.
Horse,
meat
0.1
Horse,
meat
byproducts
0.1
Milk
0.01
Revoke
The
available
data
indicate
that
a
tolerance
for
milk
is
not
required.

Poultry,
fat
0.01
Revoke
The
available
data
indicate
that
tolerances
for
poultry
commodities
are
not
required.
Poultry,
meat
0.01
Poultry,
meat
byproducts
0.01
Sheep,
fat
0.1
Revoke
The
available
data
indicate
that
tolerances
for
sheep
commodities
are
not
required.
Sheep,
meat
0.1
Sheep,
meat
byproducts
0.1
Tolerances
To
Be
Proposed
Under
40
CFR
§
180.450
(
a)

Barley,
hay
None
established
TBD
Cotton,
gin
byproducts
None
established
TBD
Oat,
hay
None
established
TBD
Wheat,
hay
None
established
TBD
1.
40
CFR
§
180.450(
a)
states
that
there
are
no
U.
S.
registrations
for
banana
(
whole)
as
of
9/
22/
93.
2.
TBD
=
To
be
determined.
3.
Crop
field
trial
data
depicting
residues
of
triadimenol,
KWG
1342,
and
KWG
1732
in/
on
field
corn
(
forage,
grain,
stover),
sweet
corn
(
forage,
K+
CWHR,
grain,
and
stover),
cotton
(
undelinted
seed
and
gin
byproducts),
and
wheat
(
forage,
grain,
hay,
and
straw)
grown
from
seed
treated
at
the
maximum
rate
are
required
pending
the
results
from
the
requested
metabolism
studies.

Residue
Data
used
for
Acute
and
Chronic
Dietary
Assessments
The
anticipated
residue
estimates
for
the
acute
dietary
assessment
are
based
on
the
available
field
trial
data
for
bananas
while
incorporating
existing
tolerance
values
for
the
remaining
commodities.
A
residue
distribution
file
(
RDF)
was
used
for
bananas
along
with
100%
CT.
Tolerance
values
were
used
for
barley,
corn,
cotton,
oats,
rye,
and
wheat
to
likely
account
for
all
residues
of
concern
(
triadimenol,
KWG
1342,
and
KWG
1732),
since
field
trial
studies
sampled
for
triadimenol
and
KWG
1342
only.
The
average
residue
from
the
submitted
field
trials
conducted
with
wheat
(
MRID
42712101)
is
0.0125
ppm
(
higher
than
the
field
trials
conducted
with
barley
and
oats).
If
the
available
metabolism
data
for
wheat
grain
is
considered
(
35%
of
KWG
1732
was
identified,
triadimenol
was
found
at
6%,
and
KWG
1342
at
21%),
the
highest
average
residue
expected
for
KWG
1732
would
be
0.0162
ppm,
thus
yielding
a
total
residue
of
0.03
ppm
(
0.0125
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of
21
ppm
+
0.0162
ppm),
which
is
less
than
the
existing
tolerance
of
0.05
ppm.
Crop
field
trial
data
depicting
the
potential
for
concentration
of
triadimenol
residues
of
concern
in/
on
field
corn
processed
commodities
(
MRID
44519801)
and
cotton
processed
commodities
(
MRID
44519802)
indicate
that
residues
of
triadimenol,
KWG
1342,
and
KWG
1732
were
nonquantifiable
(<
0.05
for
corn
and
<
0.02
for
cotton)
following
treatment
at
5x
the
maximum
application
rate.
Additionally,
the
field
trial
data
submitted
for
corn
and
cotton
demonstrate
that
residues
of
triadimenol
and
KWG
1342
were
less
than
the
method
LOD
of
0.01
for
corn
grain
and
cotton
seed.
Therefore,
using
tolerance
values
for
corn
grain
(
0.05
ppm)
and
cotton
seed
(
0.02
ppm)
are
not
expected
to
underestimate
exposure.
Tolerance
values
were
used
for
the
chronic
dietary
assessment.

Processing
Factors
Data
from
the
processing
studies
were
used
in
this
assessment
for
several
commodities
along
with
a
DEEM
Version
7.81
default
processing
factor
for
dried
banana
(
3.9x).
Processing
studies
for
field
corn
and
cotton
indicate
that
residues
of
triadimenol,
KWG
1342,
and
KWG
1732
were
nonquantifiable
following
treatment
at
5x
the
maximum
application
rate;
therefore,
processing
studies
for
these
commodities
were
not
conducted.
A
processing
factor
of
2.1x
was
utilized
for
barley,
oat,
and
wheat
bran.
All
other
processed
commodities
showed
little
or
no
concentration
in
the
available
processing
studies.
For
detailed
considerations
of
processing
factors
see
"
Triadimenol.
Summary
of
Analytical
Chemistry
and
Residue
Data
for
the
Tolerance
Reassessment
Eligibility
Decision
(
TRED)
Document"
under
guideline
section
860.1520
(
S.
Ary,
D314891,
11/
17/
2005).

Usage
Information
No
usage
data
are
available
for
triadimenol,
so
100%
crop
treated
were
assumed
for
all
commodities.

Residue
Estimates
for
Individual
Crops
The
anticipated
residue
estimates
for
the
acute
dietary
exposure
assessment
are
based
on
the
available
field
trial
data
for
bananas
while
incorporating
existing
tolerance
values
for
the
remaining
commodities.
Existing
tolerances
were
used
for
the
chronic
dietary
exposure
assessment.
All
triadimenol
acute
and
chronic
residue
estimates
for
crop
commodities
are
listed
in
Attachment
1.

III.
Drinking
Water
Data
The
drinking
water
values
used
in
the
dietary
risk
assessment
were
provided
by
the
Environmental
Fate
and
Effects
Division
(
EFED)
in
the
following
memorandum:
"
TRED
for
Triadimenol
(
PC
#
127201)
Drinking
Water
Assessment
Environmental
Fate
and
Effects
Division"
(
J.
Breithaupt,
D321519,
2/
9/
2005).
Water
residues
were
incorporated
in
the
DEEM­
FCID
 
into
the
food
categories
"
water,
direct,
all
sources"
and
"
water,
indirect,
all
sources".

The
estimated
surface
drinking
water
concentrations
(
EDWCs)
for
triadimenol
were
moderately
refined
and
calculated
using
PRZM
(
Pesticide
Root
Zone
Model)
and
EXAMS
(
Exposure
Analysis
Modeling
System)
for
use
in
the
human
health
risk
assessment.
The
estimated
groundwater
concentrations
for
triadimenol
were
unrefined
and
calculated
using
SCI­
GROW
(
Screening
Concentration
In
Ground
Water),
however,
were
not
used
in
the
assessment
because
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Dietary
Exposure
Assessment
­
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Barcode:
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9
of
21
residues
are
shown
to
be
much
higher
in
surface
water.

The
EDWCs
were
calculated
from
the
use
of
triadimenol
as
a
seed
treatment
to
wheat,
corn,
and
cotton.
The
wheat
scenario
produced
the
highest
concentrations
and
is
used
in
this
dietary
assessment.
Only
triadimenol
in
drinking
water
is
considered
in
the
dietary
risk
assessment;
it
was
the
major
residue
found
in
the
available
triadimefon
aerobic
soil
metabolism
study.
Other
degradates
(
e.
g.,
CPMT
or
chlorophenoxymethyltriazole
or
4­
chlorophenoxy­
1,2,4­
triazol­
1­
ylmethane
are
not
considered
in
this
assessment
because
there
is
insufficient
data
on
the
specific
rates
and
locales
of
formation
and
conditions
under
which
formation
occurs
to
evaluate
secondary
degradates
as
part
of
total
triadimenol
residues;
however,
based
on
current
information,
other
degradates
are
not
at
this
time
considered
to
be
essential
components
of
this
drinking
water
evaluation.

Acute
Dietary
Assessment
The
30
year
annual
peak
surface
water
concentration
of
0.000393
ppm
was
used
for
the
acute
dietary
assessment.

Chronic
Dietary
Assessment
The
1
in
10
year
annual
mean
surface
water
concentration
of
0.000194
ppm
was
used
for
the
chronic
dietary
assessment.

IV.
DEEM­
FCID
 
Program
and
Consumption
Information
Triadimenol
acute
and
chronic
dietary
exposure
assessments
were
conducted
using
the
Dietary
Exposure
Evaluation
Model
software
with
the
Food
Commodity
Intake
Database
(
DEEMFCID
 
,
Version
2.03),
which
incorporates
consumption
data
from
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII),
1994­
1996
and
1998.
The
1994­
96,
98
data
are
based
on
the
reported
consumption
of
more
than
20,000
individuals
over
two
non­
consecutive
survey
days.
Foods
"
as
consumed"
(
e.
g.,
apple
pie)
are
linked
to
EPA­
defined
food
commodities
(
e.
g.
apples,
peeled
fruit
­
cooked;
fresh
or
N/
S;
baked;
or
wheat
flour
­
cooked;
fresh
or
N/
S,
baked)
using
publicly
available
recipe
translation
files
developed
jointly
by
USDA/
ARS
and
EPA.
For
chronic
exposure
assessment,
consumption
data
are
averaged
for
the
entire
U.
S.
population
and
within
population
subgroups,
but
for
acute
exposure
assessment
are
retained
as
individual
consumption
events.
Based
on
analysis
of
the
1994­
96,
98
CSFII
consumption
data,
which
took
into
account
dietary
patterns
and
survey
respondents,
HED
concluded
that
it
is
most
appropriate
to
report
risk
for
the
following
population
subgroups:
the
general
U.
S.
population,
all
infants
(
less
than
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
adults
20­
49,
females
13­
49,
and
adults
50+
years
old.

For
chronic
dietary
exposure
assessment,
an
estimate
of
the
residue
level
in
each
food
or
foodform
(
e.
g.,
orange
or
orange
juice)
on
the
food
commodity
residue
list
is
multiplied
by
the
average
daily
consumption
estimate
for
that
food/
food
form
to
produce
a
residue
intake
estimate.
The
resulting
residue
intake
estimate
for
each
food/
food
form
is
summed
with
the
residue
intake
estimates
for
all
other
food/
food
forms
on
the
commodity
residue
list
to
arrive
at
the
total
average
estimated
exposure.
Exposure
is
expressed
in
mg/
kg
body
weight/
day
and
as
a
percent
of
the
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
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10
of
21
cPAD.
This
procedure
is
performed
for
each
population
subgroup.

For
acute
exposure
assessments,
individual
one­
day
food
consumption
data
are
used
on
an
individual­
by­
individual
basis.
The
reported
consumption
amounts
of
each
food
item
can
be
multiplied
by
a
residue
point
estimate
and
summed
to
obtain
a
total
daily
pesticide
exposure
for
a
deterministic
exposure
assessment,
or
"
matched"
in
multiple
random
pairings
with
residue
values
and
then
summed
in
a
probabilistic
assessment.
The
resulting
distribution
of
exposures
is
expressed
as
a
percentage
of
the
aPAD
on
both
a
user
(
i.
e.,
only
those
who
reported
eating
relevant
commodities/
food
forms)
and
a
per­
capita
(
i.
e.,
those
who
reported
eating
the
relevant
commodities
as
well
as
those
who
did
not)
basis.
In
accordance
with
HED
policy,
per
capita
exposure
and
risk
are
reported
for
all
tiers
of
analysis.
However,
for
tiers
1
and
2,
any
significant
differences
in
user
vs.
per
capita
exposure
and
risk
are
specifically
identified
and
noted
in
the
risk
assessment.

V.
Toxicological
Information
A
summary
of
the
toxicological
doses
and
endpoints
selected
for
the
dietary
exposure
assessments
are
provided
in
Table
4.

Table
4.
Summary
of
Toxicological
Doses
and
Endpoints
for
Triadimenol.
1,2
Exposure
Scenario
Dose
Used
in
Risk
Assessment,
UF
Special
FQPA
SF*
and
Level
of
Concern
for
Risk
Assessment
Study
and
Toxicological
Effects
Acute
Dietary
(
general
population)
NOAEL
=
3.4
mg/
kg/
day
UF
=
1000
Acute
RfD
=
0.0034
mg/
kg/
day
FQPA
SF
=
1X
aPAD
=
acute
RfD
FQPA
SF
=
0.0034
mg/
kg/
day
Subchronic
neurotoxicity
study
in
rats.
LOAEL
=
54.6/
68.7
mg/
kg/
day
based
largely
on
hyperactivity.

Chronic
Dietary
(
all
populations)
NOAEL
=
3.4
mg/
kg/
day
UF
=
1000
Acute
RfD
=
0.0034
mg/
kg/
day
FQPA
SF
=
1X
cPAD
=
chronic
RfD
FQPA
SF
=
0.0034
mg/
kg/
day
Subchronic
neurotoxicity
study
in
rats.
LOAEL
=
54.6/
68.7
mg/
kg/
day
based
largely
on
hyperactivity.

Cancer
(
oral,
dermal,
inhalation)
Classification:
Category
C
"
possible
human
carcinogen"
based
on
increased
incidence
of
hepatocellular
adenomas
in
females.

1.
Triadimenol:
HED
Chapter
of
the
Tolerance
Reassessment
Eligibility
Decision
(
TRED)
Document.
PC
Code:
127201,
CAS
Reg.
No.
55219­
65­
3,
DP
Barcode:
D314964.
11/
23/
2005.
2.
UF
=
uncertainty
factor,
FQPA
SF
=
Special
FQPA
safety
factor,
NOAEL
=
no
observed
adverse
effect
level,
LOAEL
=
lowest
observed
adverse
effect
level,
PAD
=
population
adjusted
dose
(
a
=
acute,
c
=
chronic)
RfD
=
reference
dose,
MOE
=
margin
of
exposure,
LOC
=
level
of
concern,
NA
=
Not
Applicable.

VI.
Results/
Discussion
As
stated
above,
for
acute
and
chronic
assessments,
HED
is
concerned
when
dietary
risk
exceeds
100%
of
the
PAD.
The
DEEM­
FCID
 
analyses
estimate
the
dietary
exposure
of
the
U.
S.
population
and
various
population
subgroups.
The
acute
dietary
exposure
analysis
results
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
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of
21
reported
in
Table
4
are
for
the
general
U.
S.
population,
all
infants
(
less
than
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
adults
20­
49,
adults
50+
years,
and
females
13­
49.
The
chronic
dietary
exposure
analysis
results
reported
in
Table
5
are
for
the
general
U.
S.
population,
all
infants
(
less
than
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
adults
20­
49,
adults
50+
years,
and
females
13­
49.
Cancer
risk
is
determined
for
the
general
U.
S.
population
only.

Results
of
Acute
Dietary
Exposure
Analysis
This
assessment
concludes
that
for
all
supported
commodities,
the
acute
dietary
risk
estimates
do
not
exceed
HED's
level
of
concern
(
less
than
100%
of
the
aPAD)
at
the
95th
exposure
percentile
for
the
U.
S.
population
(
15%
of
the
aPAD)
and
all
population
subgroups,
with
the
highest
exposed
population
subgroup
being
children
1­
2
years
old
at
29%
of
the
aPAD.
The
results
of
the
acute
dietary
exposure
analysis
at
the
95th,
99th,
and
99.9th
percentiles
of
exposure
are
reported
in
Table
5.
The
results
of
the
acute
dietary
exposure
analysis
at
the
95th
percentile
are
reported
in
Table
6
along
with
chronic
dietary
exposure
analyses
for
easy
comparison.

The
acute
dietary
risk
estimates
for
food
alone
(
no
water)
do
no
exceed
HED's
level
of
concern
at
the
95th
exposure
percentile
for
the
U.
S.
population
(
15%
of
the
aPAD)
and
all
population
subgroups,
with
the
highest
exposed
population
subgroup
being
children
1­
2
years
old
at
28%
of
the
aPAD.
The
results
of
the
food
alone
acute
dietary
exposure
analysis
at
the
95th
percentile
are
reported
in
Table
7
along
with
food
alone
chronic
dietary
exposure
analysis
for
easy
comparison.

Table
5.
Results
of
Acute
(
Food
and
Water)
Dietary
Exposure
Analysis
for
Triadimenol
Using
DEEM­
FCID.

Population
Subgroup
aPAD
(
mg/
kg/
day)
95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
(
mg/
kg/
day)
%
aPAD*
Exposure
(
mg/
kg/
day)
%
aPAD*
Exposure
(
mg/
kg/
day)
%
aPAD*

General
U.
S.
Population
0.0034
0.000501
15
0.000791
23
0.001245
37
All
Infants
(<
1
year
old)
0.0034
0.000798
23
0.001244
37
0.001657
49
Children
1­
2
years
old
0.0034
0.000981
29
0.001367
40
0.002047
60
Children
3­
5
years
old
0.0034
0.000871
26
0.001158
34
0.001609
47
Children
6­
12
years
old
0.0034
0.000639
19
0.000857
25
0.001220
36
Youth
13­
19
years
old
0.0034
0.000436
13
0.000623
18
0.001026
30
Adults
20­
49
years
old
0.0034
0.000329
10
0.000489
14
0.000739
22
Adults
50+
years
old
0.0034
0.000249
7
0.000340
10
0.000515
15
Females
13­
49
year
old
0.0034
0.000318
9
0.000439
13
0.000718
21
The
bolded
values
represent
the
highest
exposed
populations
for
each
percentile.

Results
of
Chronic
Dietary
Exposure
Analysis
This
assessment
concludes
that
for
all
supported
commodities,
the
chronic
dietary
risk
estimates
do
not
exceed
HED's
level
of
concern
(
less
than
100%
of
the
cPAD)
for
the
U.
S.
population
(
7%
of
the
cPAD)
and
all
population
subgroups,
with
the
highest
exposed
population
subgroup
being
children
1­
2
years
old
at
23%
of
the
cPAD.
The
results
of
the
chronic
dietary
exposure
analysis
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
Page
12
of
21
are
reported
below
in
Table
6.

Table
6.
Summary
of
Acute
and
Chronic
(
Food
and
Water)
Dietary
Exposure
and
Risk
for
Triadimenol.

Population
Subgroup
Acute
Dietary
(
95th
Percentile)
Chronic
Dietary
Exposure
(
mg/
kg/
day)
%
aPAD
Exposure
(
mg/
kg/
day)
%
cPAD
General
U.
S.
Population
0.000501
15
0.000251
7
All
Infants
(<
1
year
old)
0.000798
23
0.000469
14
Children
1­
2
years
old
0.000981
29
0.000770
23
Children
3­
5
years
old
0.000871
26
0.000610
18
Children
6­
12
years
old
0.000639
19
0.000379
11
Youth
13­
19
years
old
0.000436
13
0.000224
7
Adults
20­
49
years
old
0.000329
10
0.000188
6
Adults
50+
years
old
0.000249
7
0.000178
5
Females
13­
49
years
old
0.000318
9
0.000181
5
The
bolded
values
represent
the
highest
exposed
populations
for
each
of
the
risk
assessments.

The
chronic
dietary
risk
estimates
for
food
alone
(
no
water)
do
no
exceed
HED's
level
of
concern
for
the
U.
S.
population
(
7%
of
the
cPAD)
and
all
population
subgroups,
with
the
highest
exposed
population
subgroup
being
children
1­
2
years
old
at
23%
of
the
cPAD.
The
results
of
the
food
alone
chronic
dietary
exposure
analysis
are
reported
below
in
Table
7
along
with
food
alone
acute
dietary
exposure
analysis
at
the
95th
percentile
for
easy
comparison.

Table
7.
Summary
of
Acute
and
Chronic
(
Food
Only)
Dietary
Exposure
and
Risk
for
Triadimenol.

Population
Subgroup
Acute
Dietary
(
95th
Percentile)
Chronic
Dietary
Exposure
(
mg/
kg/
day)
%
aPAD
Exposure
(
mg/
kg/
day)
%
cPAD
General
U.
S.
Population
0.000494
15
0.000247
7
All
Infants
(<
1
year
old)
0.000763
22
0.000456
13
Children
1­
2
years
old
0.000961
28
0.000764
23
Children
3­
5
years
old
0.000862
25
0.000604
18
Children
6­
12
years
old
0.000633
19
0.000375
11
Youth
13­
19
years
old
0.000428
13
0.000221
7
Adults
20­
49
years
old
0.000320
9
0.000185
5
Adults
50+
years
old
0.000240
7
0.000174
5
Females
13­
49
years
old
0.000309
9
0.000177
5
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
Page
13
of
21
The
bolded
values
represent
the
highest
exposed
populations
for
each
of
the
risk
assessments.

VII.
Characterization
of
Inputs/
Outputs
The
acute
and
chronic
dietary
exposure
assessments
were
refined
through
the
use
of
experimentally
determined
processing
factors
and
a
DEEM
Version
7.81
default
processing
factor
for
dried
bananas.
The
AR
estimate
used
for
bananas
is
considered
moderately
refined,
although
it
is
considered
highly
conservative
based
on
the
nature
of
the
residue
data
source
since
field
trial
studies
use
maximum
application
rates
and
minimum
pre­
harvest
intervals.
Additionally,
tolerance
values
were
used
for
the
remaining
commodities
for
the
acute
analysis
and
for
all
commodities
in
the
chronic
assessment,
and
100%
crop
treated
was
assumed
for
all
commodities.
HED
concludes
that
the
exposure
estimates
provided
in
this
document
are
unlikely
to
underestimate
actual
exposure.

VIII.
Conclusions
The
acute
and
chronic
dietary
risk
assessments
were
conducted
for
all
supported
triadimenol
food
uses
and
were
performed
to
support
the
tolerance
reassessment
eligibility
decision
document.
The
acute
and
chronic
assessments
show
that
dietary
exposure
and
risk
are
of
concern
for
the
supported
uses.
However,
exposure
to
triadimenol
can
occur
following
the
application
of
triadimenol
as
an
active
ingredient
as
well
as
from
the
metabolism/
degradation
of
triadimefon.
The
current
dietary
risk
assessment
only
addresses
the
use
of
triadimenol
as
an
active
ingredient
per
se.
Exposures
from
the
pesticidal
uses
of
triadimenol
have
not
been
aggregated
with
triadimenol
exposures
reflecting
metabolism
and/
or
degradation
of
triadimefon
because
risks
attributable
to
uses
of
triadimefon
already
exceed
HED's
level
of
concern
(
S.
Ary,
D314778,
11/
23/
2005)
and
because
the
resulting
apparent
increase
in
aggregate
risk
would
unduly
be
associated
with
the
registered
uses
of
triadimenol.
The
Agency
is
soliciting
comments
on
assumptions
used
in
the
current
risk
assessment.
Should
refinements
be
possible
in
the
future,
it
may
be
appropriate
to
aggregate
multiple
routes
and
sources
of
exposures
for
these
chemicals.

IX.
List
of
Attachments
Attachment
1.
Data
and
Residue
Estimates
Used
in
Dietary
Analyses.
Attachment
2.
Acute
Food
and
Water
Residue
Input
File.
Attachment
3.
Acute
Food
and
Water
Results
File.
Attachment
4.
Acute
Food
Only
Results
File.
Attachment
5.
Chronic
Food
and
Water
Residue
Input
File.
Attachment
6.
Chronic
Food
and
Water
Results
File.
Attachment
7.
Chronic
Food
Only
Results
File.
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
Page
14
of
21
Attachment
1.
Data
and
Residue
Estimates
Used
in
Dietary
Analyses.

RAC
Classification1
Data
Source
MRID
No.
of
Samples
No.
of
Detectable
Residues
Avg.
LOD
(
ppm)
%
CT
Avg.
2
%
CT
Max.
2
Processing
Factors3
Anticipated
Residue
Estimates/
Tolerance
Acute
(
Tol.,
AR,

RDF)
6
Chronic
and
Cancer
(
Tol.,

AR)

Banana
NB/
PB
Field
trial
data
and
tolerance
40615201
10
0.04,
0.05,

0.02,
0.04,

0.015,
0.015,

0.025,
0.015,

0.03,
0.05
0.036
100
100
3.9x
for
dried
RDF
1
TOTALZ=
0
TOTALLOD=
0
LODRES=
0.015
0.04
0.05
0.02
0.04
0.015
0.015
0.025
0.015
0.03
0.05
Tol
(
0.2)

Barley
grain
B
Tolerance
N/
A
N/
A
N/
A
N/
A
100
100
2.1x
for
bran
Tol
(
0.05
Tol
(
0.05)

Field
and
pop
corn
grain
B
Tolerance
N/
A
N/
A
N/
A
N/
A
100
100
None
Tol
(
0.05)
Tol
(
0.05)

Sweet
corn
grain
NB/
PB
Tolerance
N/
A
N/
A
N/
A
N/
A
100
100
None
Tol
(
0.05)
Tol
(
0.05)

Cottonseed
B
Tolerance
N/
A
N/
A
N/
A
N/
A
100
100
None
Tol
(
0.05)
Tol
(
0.02)

Oat
grain
B
Tolerance
N/
A
N/
A
N/
A
N/
A
100
100
2.1x
for
bran
Tol
(
0.05)
Tol
(
0.05)

Rye
grain
B
Tolerance
N/
A
N/
A
N/
A
N/
A
100
100
None
Tol
(
0.05)
Tol
(
0.05)

Water
N/
A
EDWCs4
N/
A
N/
A
N/
A
N/
A
N/
A
N/
A
N/
A
AR
(
0.000393)
AR
(
0.000194)

Wheat
grain
B
Tolerance
N/
A
N/
A
N/
A
N/
A
100
100
2.1x
for
bran
Tol
(
0.05)
Tol
(
0.05)

1.
Classification
of
blended
(
B),
partially
blended
(
PB),
not
blended
(
NB).

2.
No
data
were
available
for
percent
crop
treated,
so
100%
CT
was
used
in
the
dietary
assessment.

3.
Processing
study
information
may
be
found
in
the
Chemistry
Review
Document
under
guideline
section
860.1520
Processed
Food
and
Feed
(
S.
Ary,

D314891,
10/
28/
2005).

4.
EDWCs
=
Estimated
Drinking
Water
Concentrations.

5.
N/
A
=
Not
applicable.

6.
LOD
=
0.01
ppm
for
triadimenol
and
0.02
for
KWG
1342.

Attachment
2.
Acute
Food
and
Water
Residue
Input
File.
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
Page
15
of
21
U.
S.
Environmental
Protection
Agency
Ver.
2.02
DEEM­
FCID
Acute
analysis
for
TRIADIMENOL
Residue
file
name:
C:\
Pesticides\
Triazols\
Triadimenol\
Dietary\
triadimenol
acute.
R98
Analysis
Date
10­
25­
2005
Residue
file
dated:
10­
25­
2005/
21:
47:
29/
8
Reference
dose
(
aRfD)
=
0.0034
mg/
kg
bw/
day
Comment:
Food
and
Water
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
RDL
indices
and
parameters
for
Monte
Carlo
Analysis:
Index
Dist
Parameter
#
1
Param
#
2
Param
#
3
Comment
#
Code
­­­­­
­­­­
­­­­­­­­­­­­
­­­­­­­­­­­
­­­­­­­­­­­
­­­­­­­­­­
1
6
C:\
Pesticides\
Triazols\
Triadimenol\
Dietary\
RDF\
Banana,
NB
or
PB.
rdf
EPA
Crop
Food
Name
Def
Res
Adj.
Factors
RDL
Comment
Code
Grp
(
ppm)
#
1
#
2
Pntr
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­
­­­­­­
­
95000230
O
Banana
0.200000
1.000
1.000
1
NB/
PB;
Full
comment:
NB/
PB;
FTD
95000231
O
Banana­
babyfood
0.200000
1.000
1.000
1
NB/
PB;
Full
comment:
NB/
PB;
FTD
95000240
O
Banana,
dried
0.200000
3.900
1.000
1
NB/
PB;
Full
comment:
NB/
PB;
FTD
95000241
O
Banana,
dried­
babyfood
0.200000
3.900
1.000
1
NB/
PB;
Full
comment:
NB/
PB;
FTD
15000250
15
Barley,
pearled
barley
0.050000
1.000
1.000
B;
Tol
15000251
15
Barley,
pearled
barley­
babyfood
0.050000
1.000
1.000
B;
Tol
15000260
15
Barley,
flour
0.050000
1.000
1.000
B;
Tol
15000261
15
Barley,
flour­
babyfood
0.050000
1.000
1.000
B;
Tol
15000270
15
Barley,
bran
0.050000
2.100
1.000
B;
Tol
15001200
15
Corn,
field,
flour
0.050000
1.000
1.000
B;
Tol
15001201
15
Corn,
field,
flour­
babyfood
0.050000
1.000
1.000
B;
Tol
15001210
15
Corn,
field,
meal
0.050000
1.000
1.000
B;
Tol
15001211
15
Corn,
field,
meal­
babyfood
0.050000
1.000
1.000
B;
Tol
15001220
15
Corn,
field,
bran
0.050000
1.000
1.000
B;
Tol
15001230
15
Corn,
field,
starch
0.050000
1.000
1.000
B;
Tol
15001231
15
Corn,
field,
starch­
babyfood
0.050000
1.000
1.000
B;
Tol
15001240
15
Corn,
field,
syrup
0.050000
1.000
1.000
B;
Tol
15001241
15
Corn,
field,
syrup­
babyfood
0.050000
1.000
1.000
B;
Tol
15001250
15
Corn,
field,
oil
0.050000
1.000
1.000
B;
Tol
15001251
15
Corn,
field,
oil­
babyfood
0.050000
1.000
1.000
B;
Tol
15001260
15
Corn,
pop
0.050000
1.000
1.000
B;
Tol
15001270
15
Corn,
sweet
0.050000
1.000
1.000
B;
Tol
15001271
15
Corn,
sweet­
babyfood
0.050000
1.000
1.000
B;
Tol
95001280
O
Cottonseed,
oil
0.020000
1.000
1.000
B;
Tol
95001281
O
Cottonseed,
oil­
babyfood
0.020000
1.000
1.000
B;
Tol
15002310
15
Oat,
bran
0.050000
2.100
1.000
B;
Tol
15002320
15
Oat,
flour
0.050000
1.000
1.000
B;
Tol
15002321
15
Oat,
flour­
babyfood
0.050000
1.000
1.000
B;
Tol
15002330
15
Oat,
groats/
rolled
oats
0.050000
1.000
1.000
B;
Tol
15002331
15
Oat,
groats/
rolled
oats­
babyfood
0.050000
1.000
1.000
B;
Tol
15003280
15
Rye,
grain
0.050000
1.000
1.000
B;
Tol
15003290
15
Rye,
flour
0.050000
1.000
1.000
B;
Tol
86010000
O
Water,
direct,
all
sources
0.000393
1.000
1.000
86020000
O
Water,
indirect,
all
sources
0.000393
1.000
1.000
15004010
15
Wheat,
grain
0.050000
1.000
1.000
B;
Tol
15004011
15
Wheat,
grain­
babyfood
0.050000
1.000
1.000
B;
Tol
15004020
15
Wheat,
flour
0.050000
1.000
1.000
B;
Tol
15004021
15
Wheat,
flour­
babyfood
0.050000
1.000
1.000
B;
Tol
15004030
15
Wheat,
germ
0.050000
1.000
1.000
B;
Tol
15004040
15
Wheat,
bran
0.050000
2.100
1.000
B;
Tol
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
Page
16
of
21
Attachment
3.
Acute
Food
and
Water
Results
File.

U.
S.
Environmental
Protection
Agency
Ver.
2.02
DEEM­
FCID
ACUTE
Analysis
for
TRIADIMENOL
(
1994­
98
data)
Residue
file:
triadimenol
acute.
R98
Adjustment
factor
#
2
used.
Analysis
Date:
10­
25­
2005/
21:
51:
44
Residue
file
dated:
10­
25­
2005/
21:
47:
29/
8
Daily
totals
for
food
and
foodform
consumption
used.
MC
iterations
=
1000
MC
list
in
residue
file
MC
seed
=
1
Run
Comment:
"
Food
and
Water"
===============================================================================

Summary
calculations
(
per
capita):

95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
%
aRfD
Exposure
%
aRfD
Exposure
%
aRfD
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
U.
S.
Population:
0.000501
14.74
0.000791
23.27
0.001245
36.61
All
infants:
0.000798
23.47
0.001244
36.60
0.001657
48.74
Children
1­
2
yrs:
0.000981
28.86
0.001367
40.20
0.002047
60.20
Children
3­
5
yrs:
0.000871
25.63
0.001158
34.07
0.001609
47.31
Children
6­
12
yrs:
0.000639
18.80
0.000857
25.19
0.001220
35.88
Youth
13­
19
yrs:
0.000436
12.82
0.000623
18.33
0.001026
30.17
Adults
20­
49
yrs:
0.000329
9.68
0.000489
14.39
0.000739
21.74
Adults
50+
yrs:
0.000249
7.33
0.000340
10.00
0.000515
15.15
Females
13­
49
yrs:
0.000318
9.34
0.000439
12.92
0.000718
21.13
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
Page
17
of
21
Attachment
4.
Acute
Food
Only
Results
File.

U.
S.
Environmental
Protection
Agency
Ver.
2.02
DEEM­
FCID
ACUTE
Analysis
for
TRIADIMENOL
(
1994­
98
data)
Residue
file:
triadimenol
acute
(
food
only).
R98
Adjustment
factor
#
2
used.
Analysis
Date:
11­
22­
2005/
10:
24:
08
Residue
file
dated:
11­
22­
2005/
10:
17:
32/
8
Daily
totals
for
food
and
foodform
consumption
used.
MC
iterations
=
1000
MC
list
in
residue
file
MC
seed
=
1
Run
Comment:
"
Food
Only"
===============================================================================

Summary
calculations
(
per
capita):

95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
%
aRfD
Exposure
%
aRfD
Exposure
%
aRfD
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
U.
S.
Population:
0.000494
14.52
0.000781
22.98
0.001223
35.98
All
infants:
0.000763
22.45
0.001191
35.04
0.001663
48.90
Children
1­
2
yrs:
0.000961
28.25
0.001342
39.46
0.002027
59.61
Children
3­
5
yrs:
0.000862
25.35
0.001137
33.45
0.001573
46.28
Children
6­
12
yrs:
0.000633
18.61
0.000851
25.03
0.001215
35.74
Youth
13­
19
yrs:
0.000428
12.57
0.000608
17.89
0.001023
30.10
Adults
20­
49
yrs:
0.000320
9.42
0.000484
14.22
0.000733
21.56
Adults
50+
yrs:
0.000240
7.07
0.000331
9.74
0.000500
14.71
Females
13­
49
yrs:
0.000309
9.08
0.000429
12.61
0.000710
20.90
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
Page
18
of
21
Attachment
5.
Chronic
Food
and
Water
Residue
Input
File.

U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
TRIADIMENOL
1994­
98
data
Residue
file:
C:\
Pesticides\
Triazols\
Triadimenol\
Dietary\
triadimenol
chronic.
R98
Adjust.
#
2
used
Analysis
Date
10­
25­
2005
Residue
file
dated:
10­
25­
2005/
22:
15:
20/
8
Reference
dose
(
RfD)
=
0.0034
mg/
kg
bw/
day
Comment:
Food
and
Water
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Food
Crop
Residue
Adj.
Factors
Comment
EPA
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­
­­
95000230
O
Banana
0.200000
1.000
1.000
NB/
PB;
Full
comment:
NB/
PB;
Tol
95000231
O
Banana­
babyfood
0.200000
1.000
1.000
NB/
PB;
Full
comment:
NB/
PB;
Tol
95000240
O
Banana,
dried
0.200000
3.900
1.000
NB/
PB;
Full
comment:
NB/
PB;
Tol
95000241
O
Banana,
dried­
babyfood
0.200000
3.900
1.000
NB/
PB;
Full
comment:
NB/
PB;
Tol
15000250
15
Barley,
pearled
barley
0.050000
1.000
1.000
B;
Tol
15000251
15
Barley,
pearled
barley­
babyfood
0.050000
1.000
1.000
B;
Tol
15000260
15
Barley,
flour
0.050000
1.000
1.000
B;
Tol
15000261
15
Barley,
flour­
babyfood
0.050000
1.000
1.000
B;
Tol
15000270
15
Barley,
bran
0.050000
2.100
1.000
B;
Tol
15001200
15
Corn,
field,
flour
0.050000
1.000
1.000
B;
Tol
15001201
15
Corn,
field,
flour­
babyfood
0.050000
1.000
1.000
B;
Tol
15001210
15
Corn,
field,
meal
0.050000
1.000
1.000
B;
Tol
15001211
15
Corn,
field,
meal­
babyfood
0.050000
1.000
1.000
B;
Tol
15001220
15
Corn,
field,
bran
0.050000
1.000
1.000
B;
Tol
15001230
15
Corn,
field,
starch
0.050000
1.000
1.000
B;
Tol
15001231
15
Corn,
field,
starch­
babyfood
0.050000
1.000
1.000
B;
Tol
15001240
15
Corn,
field,
syrup
0.050000
1.000
1.000
B;
Tol
15001241
15
Corn,
field,
syrup­
babyfood
0.050000
1.000
1.000
B;
Tol
15001250
15
Corn,
field,
oil
0.050000
1.000
1.000
B;
Tol
15001251
15
Corn,
field,
oil­
babyfood
0.050000
1.000
1.000
B;
Tol
15001260
15
Corn,
pop
0.050000
1.000
1.000
B;
Tol
15001270
15
Corn,
sweet
0.050000
1.000
1.000
NB/
PB;
Full
comment:
NB/
PB;
Tol
15001271
15
Corn,
sweet­
babyfood
0.050000
1.000
1.000
NB/
PB;
Full
comment:
NB/
PB;
Tol
95001280
O
Cottonseed,
oil
0.020000
1.000
1.000
B;
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
Page
19
of
21
Tol
95001281
O
Cottonseed,
oil­
babyfood
0.020000
1.000
1.000
B;
Tol
15002310
15
Oat,
bran
0.050000
2.100
1.000
B;
Tol
15002320
15
Oat,
flour
0.050000
1.000
1.000
B;
Tol
15002321
15
Oat,
flour­
babyfood
0.050000
1.000
1.000
B;
Tol
15002330
15
Oat,
groats/
rolled
oats
0.050000
1.000
1.000
B;
Tol
15002331
15
Oat,
groats/
rolled
oats­
babyfood
0.050000
1.000
1.000
B;
Tol
15003280
15
Rye,
grain
0.050000
1.000
1.000
B;
Tol
15003290
15
Rye,
flour
0.050000
1.000
1.000
B;
Tol
86010000
O
Water,
direct,
all
sources
0.000194
1.000
1.000
86020000
O
Water,
indirect,
all
sources
0.000194
1.000
1.000
15004010
15
Wheat,
grain
0.050000
1.000
1.000
B;
Tol
15004011
15
Wheat,
grain­
babyfood
0.050000
1.000
1.000
B;
Tol
15004020
15
Wheat,
flour
0.050000
1.000
1.000
B;
Tol
15004021
15
Wheat,
flour­
babyfood
0.050000
1.000
1.000
B;
Tol
15004030
15
Wheat,
germ
0.050000
1.000
1.000
B;
Tol
15004040
15
Wheat,
bran
0.050000
2.100
1.000
B;
Tol
Attachment
6.
Chronic
Food
and
Surface
Water
Results
File.

U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
TRIADIMENOL
(
1994­
98
data)
Residue
file
name:
C:\
Pesticides\
Triazols\
Triadimenol\
Dietary\
triadimenol
chronic.
R98
Adjustment
factor
#
2
used.
Analysis
Date
10­
25­
2005/
22:
15:
37
Residue
file
dated:
10­
25­
2005/
22:
15:
20/
8
Reference
dose
(
RfD,
Chronic)
=
0.0034
mg/
kg
bw/
day
COMMENT
1:
Food
and
Water
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.000251
7.4%

U.
S.
Population
(
spring
season)
0.000253
7.4%
U.
S.
Population
(
summer
season)
0.000250
7.3%
U.
S.
Population
(
autumn
season)
0.000249
7.3%
U.
S.
Population
(
winter
season)
0.000254
7.5%

Northeast
region
0.000249
7.3%
Midwest
region
0.000264
7.8%
Southern
region
0.000233
6.9%
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
Page
20
of
21
Western
region
0.000268
7.9%

Hispanics
0.000280
8.2%
Non­
hispanic
whites
0.000250
7.4%
Non­
hispanic
blacks
0.000234
6.9%
Non­
hisp/
non­
white/
non­
black
0.000249
7.3%

All
infants
(<
1
year)
0.000469
13.8%
Nursing
infants
0.000279
8.2%
Non­
nursing
infants
0.000541
15.9%
Children
1­
6
yrs
0.000643
18.9%
Children
7­
12
yrs
0.000359
10.6%

Females
13­
19
(
not
preg
or
nursing)
0.000195
5.7%
Females
20+
(
not
preg
or
nursing)
0.000175
5.1%
Females
13­
50
yrs
0.000199
5.9%
Females
13+
(
preg/
not
nursing)
0.000200
5.9%
Females
13+
(
nursing)
0.000226
6.6%

Males
13­
19
yrs
0.000253
7.4%
Males
20+
yrs
0.000194
5.7%
Seniors
55+
0.000177
5.2%

Children
1­
2
yrs
0.000770
22.6%
Children
3­
5
yrs
0.000610
17.9%
Children
6­
12
yrs
0.000379
11.2%
Youth
13­
19
yrs
0.000224
6.6%
Adults
20­
49
yrs
0.000188
5.5%
Adults
50+
yrs
0.000178
5.2%
Females
13­
49
yrs
0.000181
5.3%

Attachment
7.
Chronic
Food
Only
Results
File.

U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
TRIADIMENOL
(
1994­
98
data)
Residue
file
name:
C:\
Pesticides\
Triadimenol\
Dietary\
triadimenol
chronic
(
food
only).
R98
Adjustment
factor
#
2
used.
Analysis
Date
11­
22­
2005/
10:
33:
58
Residue
file
dated:
11­
22­
2005/
10:
33:
36/
8
Reference
dose
(
RfD,
Chronic)
=
0.0034
mg/
kg
bw/
day
COMMENT
1:
Food
Only
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.000247
7.3%

U.
S.
Population
(
spring
season)
0.000249
7.3%
U.
S.
Population
(
summer
season)
0.000245
7.2%
U.
S.
Population
(
autumn
season)
0.000245
7.2%
U.
S.
Population
(
winter
season)
0.000250
7.3%

Northeast
region
0.000245
7.2%
Triadimenol
Dietary
Exposure
Assessment
­
TRED
DP
Barcode:
314928
Page
21
of
21
Midwest
region
0.000259
7.6%
Southern
region
0.000230
6.8%
Western
region
0.000264
7.8%

Hispanics
0.000275
8.1%
Non­
hispanic
whites
0.000246
7.2%
Non­
hispanic
blacks
0.000230
6.8%
Non­
hisp/
non­
white/
non­
black
0.000244
7.2%

All
infants
(<
1
year)
0.000456
13.4%
Nursing
infants
0.000274
8.1%
Non­
nursing
infants
0.000525
15.4%
Children
1­
6
yrs
0.000637
18.7%
Children
7­
12
yrs
0.000356
10.5%

Females
13­
19
(
not
preg
or
nursing)
0.000192
5.6%
Females
20+
(
not
preg
or
nursing)
0.000171
5.0%
Females
13­
50
yrs
0.000195
5.7%
Females
13+
(
preg/
not
nursing)
0.000196
5.8%
Females
13+
(
nursing)
0.000220
6.5%

Males
13­
19
yrs
0.000250
7.4%
Males
20+
yrs
0.000190
5.6%
Seniors
55+
0.000173
5.1%

Children
1­
2
yrs
0.000764
22.5%
Children
3­
5
yrs
0.000604
17.8%
Children
6­
12
yrs
0.000375
11.0%
Youth
13­
19
yrs
0.000221
6.5%
Adults
20­
49
yrs
0.000185
5.4%
Adults
50+
yrs
0.000174
5.1%
Females
13­
49
yrs
0.000177
5.2%