Document ID: EPA-HQ-OPP-2008-0276-0007
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2009-12-22T05:00Z

UNITED STAES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF

 PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM

DATE:  	20/FEBRUARY/2006  

SUBJECT:	Prosulfuron  AMENDED Acute and Chronic Dietary (Food and
Drinking Water) Exposure Assessment for the Expired Tolerances for
Residues of Prosulfuron on Grains, Cereal (Except Rice) (PP#5F4469).

PC Code:		129031

Decision Number:  	299767

DP Number:		336488

REVIEWER:	Breann Hanson, Biologist 

Alternative Risk Integration and Assessment (ARIA) Team

Risk Integration Minor Use and Emergency Response Branch 			
(RIMUERB)/Registration Division (RD) (7505P)

THROUGH:	William Cutchin, Acting Branch Senior Scientist 

		ARIA Team

Technical Review Branch/RD (7505P)

AND

		Mohsen Sahafeyen, Chemist

		Toiya Goodlow, Chemist 

		Dietary Exposure Science Advisory Council (DESAC)

		Health Effects Division (HED) (7509P)

TO:	Christina Swartz, Chemist

	Registration Action Branch, HED (7509P)

AND

Breann Hanson, Biologist

ARIA Team

RIMUERB/RD (7505P)

Executive Summary

cted using the Dietary Exposure Evaluation Model (DEEM-FCID™, Version
2.03) which uses food consumption data from the U.S. Department of
Agriculture’s Continuing Surveys of Food Intakes by Individuals
(CSFII) from 1994-1996 and 1998.  

Acute Dietary (Food and Drinking Water) Exposure Results and
Characterization 

An acute dietary assessment assuming tolerance level residues and 100%
crop treated was performed for prosulfuron.  The 1-in-10 yr annual
maximum concentration estimate of surface water exposure (1.872 ppb) was
used for drinking water in this analysis.  The acute dietary risk
assessment for prosulfuron shows that for all included commodities, the
acute dietary risk estimates are below ARIA’s level of concern (i.e.
<100% acute population adjusted doses (aPAD)).  For the U.S. population,
exposure to food and water was <1% of the aPAD at the 95th percentile. 
The acute dietary risk estimate for the highest reported exposed
population subgroup, children 1-2 years old, is <1 % of the aPAD.  

Chronic Dietary (Food and Drinking Water) Exposure Results and
Characterization

A chronic dietary assessment assuming tolerance level residues and 100%
crop treated was also conducted.  The Screening Concentration in Ground
Water (SCI-GROW) water exposure estimate (0.655 ppb) was used for
drinking water in this analysis.  The chronic dietary risk assessment
shows that for all included commodities, the chronic dietary risk
estimates are below ARIA’s level of concern (i.e. <100% chronic
population adjusted doses (cPAD)).  For the U.S. population the exposure
for food and water was <1% of the cPAD.  The chronic dietary risk
estimate for the highest reported exposed population subgroup, children
1-2 years old, is <1% of the cPAD.

Cancer 

Prosulfuron is classified as a Group D carcinogen, “not classifiable
as to human carcinogenicity”.  No new studies are required; therefore,
quantification of human cancer risk is not required and a cancer dietary
assessment was not performed.

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose.  This is the
population adjusted dose (PAD), which HED has concluded will result in
no unreasonable adverse health effects.  This dose is referred to as the
population adjusted dose (PAD).  The PAD is equivalent to point of
departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty
or safety factors.  For acute and non-cancer chronic exposures, HED is
concerned when estimated dietary risk exceeds 100% of the PAD. 
References which discuss the acute and chronic risk assessments in more
detail are available on the EPA/pesticides web site:  “Available
Information on Assessing Exposure from Pesticides, A User’s Guide”,
6/21/2000, web link: 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see
SOP 99.6 (20/08/1999).

The most recent dietary risk assessment for prosulfuron was conducted by
B. Hanson (DP Number: 333782, 19/12/2006) for its use on corn, milk and
livestock commodities and cereal grains (except rice).  ARIA has since
determined that the tolerances proposed under PP#4F4336 (corn and
livestock commodity tolerances) are not required.  Corn uses are covered
by the cereal grain tolerance and there is no reasonable expectation of
residues in livestock commodities (40CFR§6(a)(3)).  This current
dietary risk assessment amends the previous 2006 assessment.

II.	Residue Information

Prosulfuron Background:

In this analysis the acute and chronic dietary exposure and risk
estimates resulting from food intake were determined for the general
U.S. population and various population subgroups resulting from the
conversion of the expired time-limited tolerances on cereal grain
(except rice) to permanent tolerances for prosulfuron.

Time-limited tolerances have been established in 40 CFR §180.481 for
residues of prosulfuron
(1-(4-methoxy-6-methyl-triazin-2-yl)-3-[2-(3,3,3-trifluoropropyl)-phenyl
sulfonyl]-urea) in/on corn (grain and fresh), cereal grain (except
rice), milk and livestock commodities.  

The above tolerances were time-limited based on deficiencies noted by
HED (DP Numbers: 221422 and 226958, G. Kramer, 29/10/1996).  In a later
HED memo (DP Number: 242049, G. Herndon, 04/04/2000) it was determined
that for the purposes of the Section 3 registration of prosulfuron on
cereal grains (PP#5F4469) the requirements had been met.  A dietary risk
assessment was conducted (as noted above) for this use, although the
current CFR lists the tolerance as time-limited and expired.  No risk
assessment could be located for this use on cereal grains.  In 2000, the
remaining tolerances on corn (grain and fresh), milk and livestock
commodities were not reestablished at that time due to continued
deficiencies.  Most recently, HED has determined that all toxicological
data requirements have since been satisfied (DP Number: 331656, L.
Taylor, 16/08/2006).  

The residue of concern is for prosulfuron parent.

Residue Data Used for Acute and Chronic Assessments:

Both the acute and chronic assessments were based on the assumption of
recommended tolerance-level residues and 100% crop treated (%CT) for all
commodities.  

As part of the current petition, ARIA recommends establishing permanent
tolerances for residues of prosulfuron, as shown in Table 1.

Table 1.   Tolerance Summary for Prosulfuron                          

Commodity	Recommended Tolerance

Cereal grain (except rice)	0.01 ppm

III.	Drinking Water Data

The drinking water residues used in the dietary risk assessment were
provided by the Environmental Fate and Effects Division (EFED) and
summarized in the following memorandum: “Drinking Water Exposure
Assessment for Prosulfuron Usage on Small Grains and Corn,” (DP
Number: 326831, Barrett, M.,  20/11/2006) and incorporated directly into
this dietary assessment.  Water residues were incorporated in DEEM-FCID
into the food categories “water, direct, all sources” and “water,
indirect, all sources.” 

Parent prosulfuron is extremely persistent in soil with half-lives
generally of 151 to >730 days in the root zone and has the potential to
hydrolyze rapidly in acidic soils (based on measurement of a 10-day
half-life in pH 5 sterile, distilled water).  Label restrictions also
acknowledge this property when addressing concerns / use restrictions
because of possible carryover of residue levels toxic to rotational
crops.  Prosulfuron is also very mobile in soil with Kd values of 0.074
to 0.293 and Koc values of 18 to 41 in four American test soils with
measured pH values ranging from 6.5 to 7.7.

The exposure assessment was performed for prosulfuron parent on ground
and surface waters under the assumption that only parent contributes to
the total toxic residues in drinking water.  However, prosulfuron does
have persistent and mobile degradates.   The degradate fate data were
reviewed as well, however, because the degradates have not been
established to be a human health concern EFED concluded that it did not
appear necessary to include degradate exposure in the Drinking Water
Assessment for prosulfuron at this time.  

The SCI-GROW model was used to estimate ground water concentrations and
the Pesticide Root Zone Model (PRZM) and Exposure Analysis Modeling
System (EXAMS) models were used to estimate surface water
concentrations.

Based on the modeling results using the SCI-GROW model for sorghum,
wheat, barley, and other small grain uses, groundwater concentrations of
prosulfuron are 0.655 ppb for both the acute and chronic assessments.  
This value represents the maximum estimated drinking water concentration
of parent prosulfuron alone that might be found in groundwater from the
use of prosulfuron at the maximum application rate.  

To estimate surface water concentrations, the PRZM-EXAMS model was used
based on aerial application of prosulfuron.  The 1-in-10 yr annual
maximum concentration estimate is 1.872 ppb and the 1-in-10 year annual
mean concentration is 0.583 ppb.  The application rate used in the
surface water assessment represents the maximum single application rate
on the proposed label for the relevant crops. 

Prosulfuron may be applied on grain sorghum (milo), wheat, barley, rye,
oats, triticale, proso millet, and following small grain harvest up to a
maximum single application rate of 0.0356 lb ai/A and a maximum seasonal
application rate of 0.0356 lb ai/A.  

The most conservative estimates for acute exposure (1.872 ppb) and
chronic exposure (0.655 ppb) were used in this analysis (Table 2,
below).

Table 2.  Water Numbers Used in the Prosulfuron Dietary Risk Assessment
Based on SCI-GROW and PRZM-EXAMS Models

	Acute Exposure Estimates (ppb)	Chronic Exposure Estimates

(ppb)

SCI-GROW

(Ground water)	0.655	0.655

PRZM-EXAMS

(Surface water)	1.872 

	0.583

.	DEEM-FCID™ Program and Consumption Information

Prosulfuron acute and chronic dietary exposure assessments were
conducted using the Dietary Exposure Evaluation Model software with the
Food Commodity Intake Database (DEEM-FCID™, Version 2.03), which
incorporates consumption data from USDA’s Continuing Surveys of Food
Intakes by Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98
data are based on the reported consumption of more than 20,000
individuals over two non-consecutive survey days.  Foods “as
consumed” (e.g., apple pie) are linked to EPA-defined food commodities
(e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicly available recipe
translation files developed jointly by USDA/ARS and EPA.  For chronic
exposure assessment, consumption data are averaged for the entire U.S.
population and within population subgroups, but for acute exposure
assessment are retained as individual consumption events.  Based on
analysis of the 1994-96, 98 CSFII consumption data, which took into
account dietary patterns and survey respondents, HED concluded that it
is most appropriate to report risk for the following population
subgroups: the general U.S. population, all infants (<1 year old),
children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49,
females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., only those who reported
eating relevant commodities/food forms) and a per-capita (i.e., those
who reported eating the relevant commodities as well as those who did
not) basis.  In accordance with HED policy, per capita exposure and risk
are reported for all tiers of analysis.  However, for tiers 1 and 2, any
significant differences in user vs. per capita exposure and risk are
specifically identified and noted in the risk assessment.

V.	Toxicological Information

In a HED memorandum entitled “PROSULFURON: Toxicology/Hazard
Assessment update for Prosulfuron Human Health Risk Assessment“ (DP
Number: 331656, L. Taylor, TXR No. 0054301, 16/08/2006), an update was
provided for determining the hazard/toxicological endpoint selections to
be used in this, and subsequent, risk assessments.   As part of this
review update, changes from the previous (1995) risk assessment were
highlighted, including changes in the acute dietary and chronic RfD and
inclusion of a FQPA assessment.  Additionally, the rationale for not
requiring a developmental neurotoxicity study in rats, recommended
previously by the Hazard Identification Assessment Review Committee
(HIARC) in 2000, was provided.  

For acute dietary exposure, the toxicological endpoint was selected from
an acute neurotoxicity study in rats in which the NOAEL of 10 mg/kg is
based on abnormal gait.  For the chronic dietary exposure, the endpoint
was selected from a subchronic oral toxicity study in dogs in which the
NOAEL of 5.3 mg/kg/day is based on decreased body-weight gain and feed
efficiency, hematological findings and hepatotoxicity in both sexes.  

The FQPA SF was reduced to 1x based on toxicological considerations by
HED, as noted in the review update.

Prosulfuron is classified as “not classifiable as to human
carcinogenicity”.  No new studies are required; therefore,
quantification of human cancer risk is not required and a cancer dietary
assessment was not performed.

Table 3.  Summary of Toxicological Endpoints for Use in Human Health
Risk Assessment

Exposure

Scenario	Dose Used in Risk Assessment,

UF	Hazard and Exposure/FQPA Safety Factor	Study and Toxicological
Effects

Acute Dietary

all populations	NOAEL = 10 mg/kg

UF = 100

Acute RfD = 0.1 mg/kg/day	FQPA SF = 1X

aPAD =  0.1 mg/kg/day	Acute Neurotoxicity Study - Rat

LOAEL = 250 mg/kg/day, based on abnormal gait in females.

Chronic Dietary

all populations	NOAEL= 5.3 mg/kg/day

UF = 100

Chronic RfD = 0.053 mg/kg/day	FQPA SF = 1X

cPAD = 0.053 mg/kg/day	Subchronic Oral Toxicity Study - Dog

LOAEL = 54 mg/kg/day, based on decreased body-weight gain and feed
efficiency, hematological findings and hepatotoxicity in both sexes.

Cancer

(oral, dermal, inhalation)	Prosulfuron is classified as “not
classifiable as to human carcinogenicity”.

1 UF = uncertainty factor; NOAEL = no observed adverse effect level;
LOAEL = lowest observed adverse effect level; PAD = population adjusted
dose (a = acute, c = chronic); RfD = reference dose; MOE = margin of
exposure.

VI.	Results/Discussion 

ry risk exceeds 100% of the PAD.  The DEEM-FCID™ analyses estimate the
dietary exposure of the U.S. population and various population
subgroups.  The results reported in the Summary Table (Table 4) are for
the general U.S. population, all infants (<1 year old), children 1-2,
children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49,
and adults 50+ years.  

Results of Acute and Chronic Dietary Exposure Analyses

The acute dietary exposure for food and surface water was < 1% of the
aPAD for the U.S. population.  The acute dietary exposure for the
highest reported exposed population subgroup, children 1-2 years old,
was <1% of the aPAD.

The chronic dietary exposure for food and surface water was < 1% of the
cPAD for the U.S. population.  The chronic dietary exposure for the
highest reported exposed population subgroup, children 1-2 years old,
was <1% of the cPAD.

The results of the acute and chronic dietary exposure analyses are
reported in the Summary Table (Table 4, below).  

Table 4.  Summary of Dietary (Food and Drinking Water) Exposure Risk for
Prosulfuron

Population Subgroup	Acute Dietary

(95th Percentile)	Chronic Dietary

	Dietary Exposure (mg/kg/day)	% aPAD*	Dietary Exposure

(mg/kg/day)	% cPAD*

General U.S. Population	0.000176	<1	0.000054	<1

All Infants (< 1 year old)	0.000233	<1	0.000086	<1

Children 1-2 years old	0.000306	<1	0.000110	<1

Children 3-5 years old	0.000284	<1	0.000114	<1

Children 6-12 years old	0.000209	<1	0.000082	<1

Youth 13-19 years old	0.000146	<1	0.000057	<1

Adults 20-49 years old	0.000139	<1	0.000046	<1

Adults 50+ years old	0.000112	<1	0.000036	<1

Females 13-49 years old	0.000133	<1	0.000044	<1

* *The values for the highest exposed population for each type of risk
assessment are bolded.

These analyses are considered to be conservative dietary exposure
assessments because proposed tolerances and 100% CT were used.  Further
refinement to the analyses could be made through the use of anticipated
residues, incorporation of percentages of crops treated with
prosulfuron, and/or monitoring data that better reflect residues at the
time of consumption.  Since risk estimates are below ARIA’s level of
concern, a more highly refined analysis is not needed at this time.

VII.	Conclusions

Acute and chronic dietary exposure assessments were conducted for the
proposed food uses and permanent tolerances, including potential
exposure from drinking water.  

  

The acute dietary (food + drinking water) exposure to prosulfuron is
below ARIA’s level of concern for the general U.S. population and all
population subgroups.  The acute dietary exposure for food and water was
<1% of the aPAD at the 95th percentile for the general U.S. population
and <1% of the aPAD for the highest exposed population subgroup,
children 1-2 years old.  

The chronic dietary (food + drinking water) exposure to prosulfuron is
below ARIA’s level of concern for the general U.S. population and all
population subgroups.  The chronic dietary exposure was <1% cPAD for the
general U.S. population and <1% of the cPAD for children 1-2 years old,
the most highly exposed population subgroup. 

VIII.	List of Attachments

Attachment 1:  Acute Food plus Water Residue Input File

Attachment 2:  Acute Results File

Attachment 3:  Chronic Food plus Water Residue Input File

Attachment 4:  Chronic Results File

cc:  B. Hanson

Attachment 1:  Acute Food plus Water Residue Input File

U.S. Environmental Protection Agency                                
Ver. 2.02

DEEM-FCID Acute analysis for PROSULFURON

Residue file name: C:\Documents and Settings\bhanson\My
Documents\Breann's Work\ARIA\Prosulfuron\FINALS\129031a.R98

Analysis Date 02-06-2007             Residue file dated:
02-06-2007/13:03:11/8

Reference dose: aRfD = 0.1 mg/kg bw/day  NOEL = 10 mg/kg bw/day

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Food Name                         (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

15000250 15   Barley, pearled barley             0.010000   1.000 
1.0005F4469

15000251 15   Barley, pearled barley-babyfood    0.010000   1.000 
1.0005F4469

15000260 15   Barley, flour                      0.010000   1.000 
1.0005F4469

15000261 15   Barley, flour-babyfood             0.010000   1.000 
1.0005F4469

15000270 15   Barley, bran                       0.010000   1.000 
1.0005F4469

15000650 15   Buckwheat                          0.010000   1.000 
1.0005F4469

15000660 15   Buckwheat, flour                   0.010000   1.000 
1.0005F4469

15001200 15   Corn, field, flour                 0.010000   1.000 
1.0005F4469

15001201 15   Corn, field, flour-babyfood        0.010000   1.000 
1.0005F4469

15001210 15   Corn, field, meal                  0.010000   1.000 
1.0005F4469

15001211 15   Corn, field, meal-babyfood         0.010000   1.000 
1.0005F4469

15001220 15   Corn, field, bran                  0.010000   1.000 
1.0005F4469

15001230 15   Corn, field, starch                0.010000   1.000 
1.0005F4469

15001231 15   Corn, field, starch-babyfood       0.010000   1.000 
1.0005F4469

15001240 15   Corn, field, syrup                 0.010000   1.500 
1.0005F4469

15001241 15   Corn, field, syrup-babyfood        0.010000   1.500 
1.0005F4469

15001250 15   Corn, field, oil                   0.010000   1.000 
1.0005F4469

15001251 15   Corn, field, oil-babyfood          0.010000   1.000 
1.0005F4469

15001260 15   Corn, pop                          0.010000   1.000 
1.0005F4469

15001270 15   Corn, sweet                        0.010000   1.000 
1.0005F4469

15001271 15   Corn, sweet-babyfood               0.010000   1.000 
1.0005F4469

15002260 15   Millet, grain                      0.010000   1.000 
1.0005F4469

15002310 15   Oat, bran                          0.010000   1.000 
1.0005F4469

15002320 15   Oat, flour                         0.010000   1.000 
1.0005F4469

15002321 15   Oat, flour-babyfood                0.010000   1.000 
1.0005F4469

15002330 15   Oat, groats/rolled oats            0.010000   1.000 
1.0005F4469

15002331 15   Oat, groats/rolled oats-babyfood   0.010000   1.000 
1.0005F4469

15003280 15   Rye, grain                         0.010000   1.000 
1.0005F4469

15003290 15   Rye, flour                         0.010000   1.000 
1.0005F4469

15003440 15   Sorghum, grain                     0.010000   1.000 
1.0005F4469

15003450 15   Sorghum, syrup                     0.010000   1.000 
1.0005F4469

15003810 15   Triticale, flour                   0.010000   1.000 
1.0005F4469

15003811 15   Triticale, flour-babyfood          0.010000   1.000 
1.0005F4469

86010000 O    Water, direct, all sources         0.001872   1.000  1.000

86020000 O    Water, indirect, all sources       0.001872   1.000  1.000

15004010 15   Wheat, grain                       0.010000   1.000 
1.0005F4469

15004011 15   Wheat, grain-babyfood              0.010000   1.000 
1.0005F4469

15004020 15   Wheat, flour                       0.010000   1.000 
1.0005F4469

15004021 15   Wheat, flour-babyfood              0.010000   1.000 
1.0005F4469

15004030 15   Wheat, germ                        0.010000   1.000 
1.0005F4469

15004040 15   Wheat, bran                        0.010000   1.000 
1.0005F4469

Attachment 2:  Acute Results File 

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for PROSULFURON                        
(1994-98 data)

Residue file: 129031a.R98                         Adjustment factor #2
NOT used.

Analysis Date: 02-06-2007/13:10:39    Residue file dated:
02-06-2007/13:03:11/8

NOEL (Acute) =  10.000000 mg/kg body-wt/day

Daily totals for food and foodform consumption used.

Run Comment: ""

========================================================================
=======

Summary calculations (per capita):

      95th Percentile             99th Percentile             99.9th
Percentile

 Exposure  % aRfD     MOE    Exposure  % aRfD     MOE    Exposure  %
aRfD     MOE  

---------- ------- -------- ---------- ------- -------- ----------
------- --------

U.S. Population:

  0.000176    0.18   56968    0.000277    0.28   36123    0.000470   
0.47   21271  

Nursing infants (<1 yr old):

  0.000233    0.23   42884    0.000457    0.46   21904    0.000679   
0.68   14734  

Children 1-2 yrs:

  0.000306    0.31   32638    0.000433    0.43   23071    0.000547   
0.55   18276  

Children 3-5 yrs:

  0.000284    0.28   35261    0.000387    0.39   25842    0.000559   
0.56   17887  

Children 6-12 yrs:

  0.000209    0.21   47734    0.000276    0.28   36205    0.000376   
0.38   26566  

Youth 13-19 yrs:

  0.000146    0.15   68422    0.000214    0.21   46808    0.000353   
0.35   28360  

Adults 20-49 yrs:

  0.000139    0.14   72173    0.000201    0.20   49814    0.000347   
0.35   28841  

Adults 50+ yrs:

  0.000112    0.11   89294    0.000152    0.15   65794    0.000240   
0.24   41732  

Females 13-49 yrs:

  0.000133    0.13   75123    0.000197    0.20   50684    0.000297   
0.30   33645  

Attachment 3:  Chronic Food plus Water Residue Input File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for PROSULFURON                       
1994-98 data

Residue file: C:\Documents and Settings\bhanson\My Documents\Breann's
Work\ARIA\Prosulfuron\FINALS\129031c.R98

                                                           Adjust. #2
NOT used

Analysis Date 02-06-2007             Residue file dated:
02-06-2007/13:06:48/8

Reference dose (RfD) = 0.053 mg/kg bw/day

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

15000250 15   Barley, pearled barley             0.010000   1.000     
1.000   5F4469

15000251 15   Barley, pearled barley-babyfood    0.010000   1.000     
1.000   5F4469

15000260 15   Barley, flour                      0.010000   1.000     
1.000   5F4469

15000261 15   Barley, flour-babyfood             0.010000   1.000     
1.000   5F4469

15000270 15   Barley, bran                       0.010000   1.000     
1.000   5F4469

15000650 15   Buckwheat                          0.010000   1.000     
1.000   5F4469

15000660 15   Buckwheat, flour                   0.010000   1.000     
1.000   5F4469

15001200 15   Corn, field, flour                 0.010000   1.000     
1.000   5F4469

15001201 15   Corn, field, flour-babyfood        0.010000   1.000     
1.000   5F4469

15001210 15   Corn, field, meal                  0.010000   1.000     
1.000   5F4469

15001211 15   Corn, field, meal-babyfood         0.010000   1.000     
1.000   5F4469

15001220 15   Corn, field, bran                  0.010000   1.000     
1.000   5F4469

15001230 15   Corn, field, starch                0.010000   1.000     
1.000   5F4469

15001231 15   Corn, field, starch-babyfood       0.010000   1.000     
1.000   5F4469

15001240 15   Corn, field, syrup                 0.010000   1.500     
1.000   5F4469

15001241 15   Corn, field, syrup-babyfood        0.010000   1.500     
1.000   5F4469

15001250 15   Corn, field, oil                   0.010000   1.000     
1.000   5F4469

15001251 15   Corn, field, oil-babyfood          0.010000   1.000     
1.000   5F4469

15001260 15   Corn, pop                          0.010000   1.000     
1.000   5F4469

15001270 15   Corn, sweet                        0.010000   1.000     
1.000   5F4469

15001271 15   Corn, sweet-babyfood               0.010000   1.000     
1.000   5F4469

15002260 15   Millet, grain                      0.010000   1.000     
1.000   5F4469

15002310 15   Oat, bran                          0.010000   1.000     
1.000   5F4469

15002320 15   Oat, flour                         0.010000   1.000     
1.000   5F4469

15002321 15   Oat, flour-babyfood                0.010000   1.000     
1.000   5F4469

15002330 15   Oat, groats/rolled oats            0.010000   1.000     
1.000   5F4469

15002331 15   Oat, groats/rolled oats-babyfood   0.010000   1.000     
1.000   5F4469

15003280 15   Rye, grain                         0.010000   1.000     
1.000   5F4469

15003290 15   Rye, flour                         0.010000   1.000     
1.000   5F4469

15003440 15   Sorghum, grain                     0.010000   1.000     
1.000   5F4469

15003450 15   Sorghum, syrup                     0.010000   1.000     
1.000   5F4469

15003810 15   Triticale, flour                   0.010000   1.000     
1.000   5F4469

15003811 15   Triticale, flour-babyfood          0.010000   1.000     
1.000   5F4469

86010000 O    Water, direct, all sources         0.000655   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.000655   1.000     
1.000   

15004010 15   Wheat, grain                       0.010000   1.000     
1.000   5F4469

15004011 15   Wheat, grain-babyfood              0.010000   1.000     
1.000   5F4469

15004020 15   Wheat, flour                       0.010000   1.000     
1.000   5F4469

15004021 15   Wheat, flour-babyfood              0.010000   1.000     
1.000   5F4469

15004030 15   Wheat, germ                        0.010000   1.000     
1.000   5F4469

15004040 15   Wheat, bran                        0.010000   1.000     
1.000   5F4469

Attachment 4:  Chronic Results File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for PROSULFURON                      (1994-98
data)

Residue file name: C:\Documents and Settings\bhanson\My
Documents\Breann's Work\ARIA\Prosulfuron\FINALS\129031c.R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 02-06-2007/13:13:14     Residue file dated:
02-06-2007/13:06:48/8

Reference dose (RfD, Chronic) = .053 mg/kg bw/day

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.000054                
0.1%

U.S. Population (spring season)             0.000054                
0.1%

U.S. Population (summer season)             0.000056                
0.1%

U.S. Population (autumn season)             0.000053                
0.1%

U.S. Population (winter season)             0.000053                
0.1%

Northeast region                            0.000051                
0.1%

Midwest region                              0.000057                
0.1%

Southern region                             0.000052                
0.1%

Western region                              0.000056                
0.1%

Hispanics                                   0.000057                
0.1%

Non-hispanic whites                         0.000054                
0.1%

Non-hispanic blacks                         0.000054                
0.1%

Non-hisp/non-white/non-black                0.000052                
0.1%

All infants (< 1 year)                      0.000086                
0.2%

Nursing infants                             0.000032                
0.1%

Non-nursing infants                         0.000106                
0.2%

Children 1-6  yrs                           0.000111                
0.2%

Children 7-12 yrs                           0.000079                
0.1%

Females 13-19 (not preg or nursing)         0.000050                
0.1%

Females 20+ (not preg or nursing)           0.000040                
0.1%

Females 13-50 yrs                           0.000046                
0.1%

Females 13+ (preg/not nursing)              0.000045                
0.1%

Females 13+ (nursing)                       0.000052    
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Children 1-2 yrs                            0.000110                
0.2%

Children 3-5 yrs                            0.000114                
0.2%

Children 6-12 yrs                           0.000082                
0.2%

Youth 13-19 yrs                             0.000057                
0.1%

Adults 20-49 yrs                            0.000046                
0.1%

Adults 50+ yrs                              0.000036                
0.1%

Females 13-49 yrs                           0.000044                
0.1%

Prosulfuron	Dietary Exposure and Risk Assessment	DP Number: 336488	

PC Code: 129031		

________________________________________________________________________
______________

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