Document ID: EPA-HQ-OPP-2005-0293-0009
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2005-12-28T05:00Z

UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
09­
SEP­
2003
MEMORANDUM
SUBJECT:
Cypermethrin
(
PC
Code
109702)
HED
Chemistry
Chapter
of
the
Reregistration
Eligibility
Decision
(
RED):
Summary
of
Product
and
Residue
Chemistry
Residue
Data.
Reregistration
Case
2130.
DP
Barcode
D289422.

FROM:
William
H.
Donovan,
Ph.
D.,
Chemist
Reregistration
Branch
3
Health
Effects
Division
(
7509C)

THROUGH:
Catherine
Eiden,
Branch
Senior
Scientist
Reregistration
Branch
3
Health
Effects
Division
(
7509C)

TO:
Mark
Seaton
Reregistration
Branch
2
Special
Review
and
Reregistration
Division
(
7508C)

Attached
are
the
product
chemistry
and
residue
chemistry
considerations
for
the
tolerance
reassessment
of
cypermethrin.
1
EXECUTIVE
SUMMARY:

C
Pertinent
data
requirements
have
not
been
satisfied
for
the
Syngenta,
FMC,
and
United
Phosphorous
technical
products.
The
following
additional
data
are
required:
(
i)
for
the
Syngenta
90%
T/
TGAI
data
concerning
color,
physical
state,
odor,
stability,
UV/
visible
absorption,
melting
point/
boiling
point,
density,
and
solubility
(
OPPTS
830.6302,
6303,
6304,
6313,
7050,
7200/
7220,
7300,
and
7840);
(
ii)
for
the
FMC
94%
T/
TGAI
data
concerning
preliminary
analysis
(
proposed
alternate
manufacturing
site),
certified
limits,
enforcement
analytical
method,
and
UV/
visible
absorption
(
OPPTS
830.1700,
1750,
1800,
and
7050);
and
(
iii)
for
the
United
Phosphorous
96.7%
T/
TGAI
data
concerning
stability
and
solubility
(
OPPTS
830.6313
and
7840).
The
Control
Solutions
and
Valent
BioSciences
technical
products
are
repackaged
from
EPA­
registered
products;
therefore,
product
chemistry
data
requirements
will
be
fulfilled
by
data
for
the
source
products.
Provided
that
the
registrants
submit
the
data
required
in
the
attached
data
summary
tables
for
the
T/
TGAIs
and
either
certify
that
the
suppliers
of
beginning
materials
and
the
manufacturing
processes
for
the
cypermethrin
technical
products
have
not
changed
since
the
last
comprehensive
product
chemistry
review
or
submit
complete
updated
product
chemistry
data
packages,
HED
has
no
objections
to
the
reregistration
of
cypermethrin
with
respect
to
product
chemistry
data
requirements.

C
Field
residue
data
should
be
submitted
for
cotton
gin
byproducts
and
a
tolerance
should
be
proposed
for
this
commodity
when
adequate
field
residue
data
have
been
submitted
and
evaluated.

C
All
cypermethrin
and
zeta­
cypermethrin
labels
pertaining
to
agricultural
crops
should
contain
the
following
restriction:
"
do
not
apply
cypermethrin
products
to
crops
that
have
been
treated
with
zeta­
cypermethrin
or
vice
versa."

C
Other
needed
label
changes
pertain
to
the
following:
1)
minimum
retreatment
intervals,
2)
minimum
aerial
application
volumes,
and
3)
impractical
cotton
forage
grazing/
feeding
restrictions.
2
CYPERMETHRIN
PC
Code
109702;
Case
2130
Reregistration
Eligibility
Decision:
Product
Chemistry
Considerations
June
11,
2003
Contract
No.
68­
W­
99­
053
Submitted
to:
U.
S.
Environmental
Protection
Agency
Arlington,
VA
Submitted
by:
Dynamac
Corporation
20440
Century
Blvd,
Suite
100
Germantown,
MD
20874
CN
O
O
CH
3
C
H
3
Cl
O
Cl
CYPERMETHRIN
REREGISTRATION
ELIGIBILITY
DECISION:

PRODUCT
CHEMISTRY
CONSIDERATIONS
PC
Code
109702;
Case
No.
2130
DESCRIPTION
OF
CHEMICAL
Cypermethrin
[(
±
)
­
alpha­
cyano­(
3­
phenoxyphenyl)
methyl
[(
±
)
­
cis,
trans­
3(
2,2­
dichloroethenyl)­
2,2­
dimethylcyclopropanecarboxylate]]
is
a
synthetic
pyrethroid
insecticide
used
on
cotton,
vegetables,
animals,
food/
feed
establishments,
buildings
and
structures,
and
ornamentals.
As
cypermethrin
has
three
asymmetric
carbons,
it
is
comprised
of
eight
stereoisomers
with
percentage
compositions
ranging
from
11­
14%
each.
Zeta­
cypermethrin
is
a
combination
of
the
same
8
isomers
with
4
insecticidally
less
active
ones
at
a
concentration
of
1%
each.
The
remaining
4
isomers,
two
of
which
are
regarded
as
being
the
most
insecticidally
active,
are
present
at
a
concentration
of
24%
each.

Empirical
Formula:
C
22
H
19
Cl
2
NO
3
Molecular
Weight:
416.30
CAS
Registry
No.:
52315­
07­
8
PC
Code:
109702
IDENTIFICATION
OF
ACTIVE
INGREDIENT
Technical
cypermethrin
is
a
dark
red
or
yellow­
brown
viscous
liquid
with
a
melting
point
of
68­
80
C
and
boiling
point
of
254
C,
density
of
1.2
g/
mL,
octanol/
water
partition
coefficient
of
102­
103,
and
vapor
pressure
of
3.1
x
10­
9
mm
Hg
at
25
C.
Cypermethrin
is
virtually
insoluble
in
water
(<
0.01
mg/
L),
but
is
soluble
in
methanol,
acetone,
acetonitrile,
toluene,
xylene,
and
methylene
dichloride.
Cypermethrin
is
not
miscible
with
hexane.

MANUFACTURING­
USE
PRODUCTS
4
A
search
of
the
Reference
Files
System
(
REFS)
conducted
3/
13/
03
identified
seven
cypermethrin
manufacturing­
use
products
(
MPs)
registered
under
PC
Code
109702;
a
list
of
the
registered
MPs
is
presented
in
Table
1.
Cypermethrin
is
a
List
B
reregistration
chemical;
therefore,
only
the
T/
TGAIs
are
subject
to
a
reregistration
eligibility
decision.

Table
1.
Registered
manufacturing­
use
products
of
Cypermethrin
(
Case
2130).

Product
1
EPA
Reg.
No.
Registrant
Comments/
Transfers
90%
T
100­
989
Syngenta
Crop
Protection,
Inc.
Formerly
Zeneca
AG
Products,
Inc.;
transferred
2/
23/
01
from
EPA
Reg.
No.
10182­
68.
REFS
should
be
updated
to
reflect
the
product
concentration
of
90%
represented
on
the
label
and
CSF
instead
of
88%.

70%
FI
100­
1018
Formerly
Zeneca
AG
Products,
Inc.;
transferred
2/
23/
01
from
EPA
Reg.
No.
10182­
140.
Formulated
from
an
EPA­
registered
technical
product;
only
T/
TGAIs
are
subject
to
a
reregistration
eligibility
decision.

94%
T
279­
3026
FMC
Corporation,
Agricultural
Products
Group
REFS
should
be
updated
to
reflect
the
product
concentration
of
94%
represented
on
the
CSF
instead
of
88%.

96.7%
T
(
r)
53883­
89
Control
Solutions,
Inc.

96.7%
T
70506­
10
United
Phosphorous,
Inc.

90%
T
(
r)
73049­
385
Valent
BioSciences
Corporation
Transferred
1/
9/
02
from
Bayer
Environmental
Science,
EPA
Reg.
No.
432­
1214.
REFS
should
be
updated
to
identify
this
as
a
technical
product
instead
of
a
formulation
intermediate.

90%
T
(
r)
73049­
386
Transferred
4/
5/
02
from
AgrEvo
Environmental
Health,
EPA
Reg.
No.
432­
725.
REFS
should
be
updated
to
identify
this
product
as
a
technical
product
instead
of
a
formulation
intermediate
and
to
reflect
the
product
concentration
of
90%
based
on
the
source
product
instead
of
88%.

1
(
r)
=
Repackaged
product.

FMC
Corporation
is
in
the
process
of
registering
zeta­
or
S­
cypermethrin,
which
is
the
resolved
active
isomer
of
RS­
cypermethrin.
Because
the
active
isomer
is
enhanced
and
no
longer
a
racemic
mixture,
S­
cypermethrin
is
considered
to
be
a
new
pesticide
active
ingredient
(
PC
Code
129064).
HED
has
determined
that
physical/
chemical
characteristics
of
zeta­
cypermethrin
and
cypermethrin
are
the
same;
however,
zeta­
cypermethrin
is
considered
to
be
a
new
product
registration
and
does
not
fall
under
the
cypermethrin
reregistration
eligibility
decision.
5
REGULATORY
BACKGROUND
The
Cypermethrin
Phase
4
Review
dated
2/
11/
91
for
ICI
Americas
and
FMC
Corporation
required
additional
product
chemistry
data
for
all
Guidelines
except
61­
1.
Data
submitted
subsequent
to
the
Phase
4
Review
have
been
reviewed
by
the
Agency.

The
current
status
of
the
product
chemistry
data
requirements
for
the
cypermethrin
T/
TGAIs
is
presented
in
the
attached
data
summary
tables.
Refer
to
these
tables
for
a
listing
of
the
outstanding
product
chemistry
data
requirements.

CONCLUSIONS
Pertinent
data
requirements
have
not
been
satisfied
for
the
Syngenta,
FMC,
and
United
Phosphorous
technical
products.
The
following
additional
data
are
required:
(
i)
for
the
Syngenta
90%
T/
TGAI
data
concerning
color,
physical
state,
odor,
stability,
UV/
visible
absorption,
melting
point/
boiling
point,
density,
and
solubility
(
OPPTS
830.6302,
6303,
6304,
6313,
7050,
7200/
7220,
7300,
and
7840);
(
ii)
for
the
FMC
94%
T/
TGAI
data
concerning
preliminary
analysis
(
proposed
alternate
manufacturing
site),
certified
limits,
enforcement
analytical
method,
and
UV/
visible
absorption
(
OPPTS
830.1700,
1750,
1800,
and
7050);
and
(
iii)
for
the
United
Phosphorous
96.7%
T/
TGAI
data
concerning
stability
and
solubility
(
OPPTS
830.6313
and
7840).
The
Control
Solutions
and
Valent
BioSciences
technical
products
are
repackaged
from
EPA­
registered
products;
therefore,
product
chemistry
data
requirements
will
be
fulfilled
by
data
for
the
source
products.
Provided
that
the
registrants
submit
the
data
required
in
the
attached
data
summary
tables
for
the
T/
TGAIs
and
either
certify
that
the
suppliers
of
beginning
materials
and
the
manufacturing
processes
for
the
cypermethrin
technical
products
have
not
changed
since
the
last
comprehensive
product
chemistry
review
or
submit
complete
updated
product
chemistry
data
packages,
HED
has
no
objections
to
the
reregistration
of
cypermethrin
with
respect
to
product
chemistry
data
requirements.
6
Case
No.
2130
Chemical
No.
109702
Case
Name:
Cypermethrin
Registrant:
Syngenta
Crop
Protection,
Inc.
Product(
s):
90%
T
(
EPA
Reg.
No.
100­
989)

PRODUCT
CHEMISTRY
DATA
SUMMARY
Guideline
Number
Requirement
Are
Data
Requirements
Fulfilled?
1
MRID
Number
2
830.1550
Product
identity
and
composition
Y
42043801,
CSF
9/
26/
91
3
830.1600
Description
of
materials
used
to
produce
the
product
Y
42068501,
42854301
4
830.1620
Description
of
production
process
Y
42068501
830.1670
Discussion
of
formation
of
impurities
Y
42068501
830.1700
Preliminary
analysis
Y
42043801
830.1750
Certified
limits
Y
42043801,
CSF
9/
26/
91
3
830.1800
Enforcement
analytical
method
Y
42043801
830.6302
Color
N
5
830.6303
Physical
state
N
5
830.6304
Odor
N
5
830.6313
Stability
to
normal
and
elevated
temperatures,
metals,
and
metal
ions
N
5
830.7000
pH
N/
A
6
830.7050
UV/
Visible
absorption
N
7
830.7200
Melting
point/
melting
range
N
5
830.7220
Boiling
point/
boiling
range
N
5
830.7300
Density/
relative
density/
bulk
density
N
5
830.7370
Dissociation
constants
in
water
Y
41887003
8,
42650601
9
830.7550
Partition
coefficient
(
n­
octanol/
water),
shake
flask
method
Y
41887003
8
830.7840
Water
solubility:
column
elution
method;
shake
flask
method
N
5
830.7950
Vapor
pressure
Y
41887003
8
1
Y
=
Yes;
N
=
No;
N/
A
=
Not
Applicable.
The
Syngenta
90%
T
was
transferred
from
Zeneca
Ag
Products
(
EPA
Reg.
No.
10182­
68).
A
letter
located
in
the
product
jacket
confirms
that
Syngenta
(
formerly
Zeneca)
may
use
FMC
data
to
fulfill
data
requirements;
however,
because
the
Syngenta
and
FMC
technical
products
contain
different
impurity
levels,
only
PAI
data
apply.

2
Bolded
references
were
reviewed
under
D183295
and
D183294,
2/
4/
93,
D.
McNeilly;
and
all
other
references
were
reviewed
as
noted.

3
RD
Memorandum,
D225261,
4/
25/
96,
S.
Mathur.

4
Under
review.

5
The
Phase
4
Review
dated
2/
11/
91
indicates
that
the
registrant
has
committed
to
conduct
a
new
study
addressing
this
data
requirement.
7
6
Data
are
not
required
because
the
TGAI
is
not
soluble
in
water.

7
The
OPPTS
Series
830,
Product
Properties
Test
Guidelines
require
data
pertaining
to
UV/
visible
absorption
for
the
PAI.

8
D166724,
9/
2/
92,
C.
Olinger
(
PAI
data
for
the
FMC
94%
T,
EPA
Reg.
No.
279­
3026).

9
Under
review
(
PAI
data
for
the
FMC
94%
T,
EPA
Reg.
No.
279­
3026).
8
Case
No.
2130
Chemical
No.
109702
Case
Name:
Cypermethrin
Registrant:
FMC
Corporation
Product(
s):
94%
T
(
EPA
Reg.
No.
279­
3026)

PRODUCT
CHEMISTRY
DATA
SUMMARY
Guideline
Number
Requirement
Are
Data
Requirements
Fulfilled?
1
MRID
Number
2
830.1550
Product
identity
and
composition
Y
00081566,
00086966,
00090032,
00097865,
00097866,
00097868,
00097869,
00102991,
00115281,
00133028,
00161909,
40513301,
CSF
9/
25/
02
3
830.1600
Description
of
materials
used
to
produce
the
product
Y
4
41887001
5
830.1620
Description
of
production
process
Y
4
41887001
5
830.1670
Discussion
of
formation
of
impurities
Y
41887001
5
830.1700
Preliminary
analysis
N
6
41887001
5,
45850201
7
830.1750
Certified
limits
N
8
41887001
5,
41887002
5,
CSF
9/
25/
02
3
830.1800
Enforcement
analytical
method
N
9
41887002
5
830.6302
Color
Y
41887003
5
830.6303
Physical
state
Y
41887003
5
830.6304
Odor
Y
41887003
5
830.6313
Stability
to
normal
and
elevated
temperatures,
metals,
and
metal
ions
Y
41887003
5,
42868201
7,
42868202
7
830.7000
pH
Y
41887003
5
830.7050
UV/
Visible
absorption
N
10
830.7200
Melting
point/
melting
range
N/
A
11
830.7220
Boiling
point/
boiling
range
Y
42868201
7,
42868202
7
830.7300
Density/
relative
density/
bulk
density
Y
41887003
5
830.7370
Dissociation
constants
in
water
Y
41887003
5,
42650601
7
830.7550
Partition
coefficient
(
n­
octanol/
water),
shake
flask
method
Y
41887003
5
830.7840
Water
solubility:
column
elution
method;
shake
flask
method
Y
41887003
5
830.7950
Vapor
pressure
Y
41887003
5
1
Y
=
Yes;
N
=
No;
N/
A
=
Not
Applicable.

2
Bolded
references
were
reviewed
in
the
Cypermethrin
Phase
4
Review,
2/
11/
91,
C.
Olinger;
and
all
other
references
were
reviewed
as
noted.

3
RD
D285776,
10/
29/
02,
L.
Kutney,
and
Letter
dated
12/
10/
02
from
G.
LaRocca,
RD.
9
4
If
alternate
steps
discussed
in
the
production
process
are
employed,
then
an
alternate
formulation
must
be
registered
and
additional
product
chemistry
data
may
be
required.

5
D166724,
9/
2/
92,
C.
Olinger.
We
note
that
relevant
data
gaps
have
been
updated
to
reflect
the
current
CSF.

6
Acceptable
data
were
previously
submitted
for
the
basic
formulation;
however,
new
data
were
submitted
for
an
alternate
production
site.
The
registrant
must
submit
data
confirming
that
levels
of
one
impurity
have
been
reduced
to
<
1.0%
in
the
cypermethrin
produced
at
the
alternate
production
site
before
HED
will
approve
designation
of
the
product
as
an
alternate
formulation.

7
Under
review.

8
Certified
limits
for
many
impurities
listed
on
the
CSF
are
much
higher
than
the
results
of
preliminary
analysis
would
appear
to
warrant
and
require
further
explanation.
The
registrant
must
also
explain
the
presence
on
the
CSF
and
the
basis
for
establishment
of
certified
limits
for
two
compounds
which
were
present
at
nondetectable
or
very
low
levels
in
the
preliminary
analysis.
Based
on
the
submitted
manufacturing
process,
the
registrant
must
specify
the
formulation
(
basic
or
alternate)
these
data
are
intended
to
support.

9
Adequate
validation
data
must
be
submitted
in
support
of
the
methods
used
to
determine
the
active
ingredient
and
impurities,
and
analytical
methods
must
be
specified
for
two
impurities
which
were
present
at
very
low
levels
in
the
preliminary
analysis
but
were
included
on
the
CSF.

10
The
OPPTS
Series
830,
Product
Properties
Test
Guidelines
require
data
pertaining
to
UV/
visible
absorption
for
the
PAI.

11
Data
are
not
required
because
the
TGAI
is
a
liquid
at
room
temperature.
10
Case
No.
2130
Chemical
No.
109702
Case
Name:
Cypermethrin
Registrant:
Control
Solutions,
Inc.
Product(
s):
96.7%
T
(
EPA
Reg.
No.
53883­
89)

PRODUCT
CHEMISTRY
DATA
SUMMARY
Guideline
Number
Requirement
Are
Data
Requirements
Fulfilled?
1
MRID
Number
2
830.1550
Product
identity
and
composition
Y
CSF
8/
6/
02
830.1600
Description
of
materials
used
to
produce
the
product
N/
A
830.1620
Description
of
production
process
N/
A
830.1670
Discussion
of
formation
of
impurities
N/
A
830.1700
Preliminary
analysis
N/
A
830.1750
Certified
limits
Y
CSF
8/
6/
02
830.1800
Enforcement
analytical
method
N/
A
830.6302
Color
N/
A
830.6303
Physical
state
N/
A
830.6304
Odor
N/
A
830.6313
Stability
to
normal
and
elevated
temperatures,
metals,
and
metal
ions
N/
A
830.7000
pH
N/
A
830.7050
UV/
Visible
absorption
N/
A
830.7200
Melting
point/
melting
range
N/
A
830.7220
Boiling
point/
boiling
range
N/
A
830.7300
Density/
relative
density/
bulk
density
N/
A
830.7370
Dissociation
constants
in
water
N/
A
830.7550
Partition
coefficient
(
n­
octanol/
water),
shake
flask
method
N/
A
830.7840
Water
solubility:
column
elution
method;
shake
flask
method
N/
A
830.7950
Vapor
pressure
N/
A
1
Y
=
Yes;
N
=
No;
N/
A
=
Not
Applicable.
This
product
is
repackaged
from
an
EPA­
registered
product;
all
product
chemistry
data
requirements
will
be
fulfilled
by
data
for
the
source
product.

2
The
CSF
was
obtained
from
the
product
jacket.
11
Case
No.
2130
Chemical
No.
109702
Case
Name:
Cypermethrin
Registrant:
United
Phosphorous,
Inc.
Product(
s):
96.7%
T
(
EPA
Reg.
No.
70506­
10)

PRODUCT
CHEMISTRY
DATA
SUMMARY
Guideline
Number
Requirement
Are
Data
Requirements
Fulfilled?
1
MRID
Number
2
830.1550
Product
identity
and
composition
Y
45462101,
CSF
12/
18/
00
830.1600
Description
of
materials
used
to
produce
the
product
Y
45462101
830.1620
Description
of
production
process
Y
45462101
830.1670
Discussion
of
formation
of
impurities
Y
45462101
830.1700
Preliminary
analysis
Y
45462101
830.1750
Certified
limits
Y
45462101,
CSF
12/
18/
00
830.1800
Enforcement
analytical
method
Y
45462101
830.6302
Color
Y
45474201
830.6303
Physical
state
Y
45474201
830.6304
Odor
Y
45474201
830.6313
Stability
to
normal
and
elevated
temperatures,
metals,
and
metal
ions
N
3
45474201,
Letter
12/
4/
01
4
830.7000
pH
Y
45474201
830.7050
UV/
Visible
absorption
Y
45474201
830.7200
Melting
point/
melting
range
N/
A
5
830.7220
Boiling
point/
boiling
range
Y
45474201
830.7300
Density/
relative
density/
bulk
density
Y
45474201
830.7370
Dissociation
constants
in
water
Y
45474201
830.7550
Partition
coefficient
(
n­
octanol/
water),
shake
flask
method
Y
41887003
6
830.7840
Water
solubility:
column
elution
method;
shake
flask
method
N
7
45474201
830.7950
Vapor
pressure
Y
41887003
6
1
Y
=
Yes;
N
=
No;
N/
A
=
Not
Applicable.

2
Bolded
references
were
reviewed
by
the
Registration
Division,
D277093,
10/
31/
01,
S.
Mathur;
all
other
references
were
reviewed
as
noted.

3
Additional
data
are
required
pertaining
to
the
stability
of
the
TGAI
at
normal
and
elevated
temperatures
and
on
exposure
to
metals
and
metal
ions.

4
RD,
D280344,
4/
23/
02,
S.
Mathur
5
Data
are
not
required
because
the
TGAI
is
a
liquid
at
room
temperature.

6
D166724,
9/
2/
92,
C.
Olinger
(
PAI
data
for
the
FMC
94%
T,
EPA
Reg.
No.
279­
3026);
under
D280344,
the
Agency
permitted
the
registrant
to
cite
FMC
data
for
these
requirements.
12
7
Data
pertaining
to
solubility
in
solvents
other
than
water
are
required.
Case
No.
2130
Chemical
No.
109702
Case
Name:
Cypermethrin
Registrant:
Valent
BioSciences
Corporation
Product(
s):
90%
T
(
EPA
Reg.
No.
73049­
385)

PRODUCT
CHEMISTRY
DATA
SUMMARY
Guideline
Number
Requirement
Are
Data
Requirements
Fulfilled?
1
MRID
Number
2
830.1550
Product
identity
and
composition
Y
3
CSF
5/
4/
00
830.1600
Description
of
materials
used
to
produce
the
product
N/
A
830.1620
Description
of
production
process
N/
A
830.1670
Discussion
of
formation
of
impurities
N/
A
830.1700
Preliminary
analysis
N/
A
830.1750
Certified
limits
Y
3
CSF
5/
4/
00
830.1800
Enforcement
analytical
method
N/
A
830.6302
Color
N/
A
830.6303
Physical
state
N/
A
830.6304
Odor
N/
A
830.6313
Stability
to
normal
and
elevated
temperatures,
metals,
and
metal
ions
N/
A
830.7000
pH
N/
A
830.7050
UV/
Visible
absorption
N/
A
830.7200
Melting
point/
melting
range
N/
A
830.7220
Boiling
point/
boiling
range
N/
A
830.7300
Density/
relative
density/
bulk
density
N/
A
830.7370
Dissociation
constants
in
water
N/
A
830.7550
Partition
coefficient
(
n­
octanol/
water),
shake
flask
method
N/
A
830.7840
Water
solubility:
column
elution
method;
shake
flask
method
N/
A
830.7950
Vapor
pressure
N/
A
1
Y
=
Yes;
N
=
No;
N/
A
=
Not
Applicable.
The
Valent
(
formerly
Aventis)
90%
T
is
repackaged
from
an
EPAregistered
product;
therefore,
product
chemistry
data
requirements
will
be
fulfilled
by
data
for
the
source
product.

2
The
CSF
was
obtained
from
the
product
jacket.

3
The
CSF
must
be
revised
to
reflect
the
nominal
concentration
and
certified
limits
of
the
active
ingredient
based
on
the
actual
amount
of
the
active
ingredient
in
the
product.
In
addition,
the
EPA
Reg.
No.
of
the
product,
the
name
of
the
current
registrant,
and
the
EPA
Reg.
No.
of
the
source
product
must
be
updated.
13
Case
No.
2130
Chemical
No.
109702
Case
Name:
Cypermethrin
Registrant:
Valent
BioSciences
Corporation
Product(
s):
90%
T
(
EPA
Reg.
No.
73049­
386)

PRODUCT
CHEMISTRY
DATA
SUMMARY
Guideline
Number
Requirement
Are
Data
Requirements
Fulfilled?
1
MRID
Number
2
830.1550
Product
identity
and
composition
Y
3
CSF
8/
26/
86
830.1600
Description
of
materials
used
to
produce
the
product
N/
A
830.1620
Description
of
production
process
N/
A
830.1670
Discussion
of
formation
of
impurities
N/
A
830.1700
Preliminary
analysis
N/
A
830.1750
Certified
limits
Y
3
CSF
8/
26/
86
830.1800
Enforcement
analytical
method
N/
A
830.6302
Color
N/
A
830.6303
Physical
state
N/
A
830.6304
Odor
N/
A
830.6313
Stability
to
normal
and
elevated
temperatures,
metals,
and
metal
ions
N/
A
830.7000
pH
N/
A
830.7050
UV/
Visible
absorption
N/
A
830.7200
Melting
point/
melting
range
N/
A
830.7220
Boiling
point/
boiling
range
N/
A
830.7300
Density/
relative
density/
bulk
density
N/
A
830.7370
Dissociation
constants
in
water
N/
A
830.7550
Partition
coefficient
(
n­
octanol/
water),
shake
flask
method
N/
A
830.7840
Water
solubility:
column
elution
method;
shake
flask
method
N/
A
830.7950
Vapor
pressure
N/
A
1
Y
=
Yes;
N
=
No;
N/
A
=
Not
Applicable.
The
Valent
(
formerly
Aventis)
90%
T
is
repackaged
from
an
EPAregistered
product;
therefore,
product
chemistry
data
requirements
will
be
fulfilled
by
data
for
the
source
product.

2
The
CSF
was
obtained
from
the
product
jacket.

3
The
CSF
must
be
revised
to
reflect
the
nominal
concentration
and
certified
limits
of
the
active
ingredient
based
on
the
actual
amount
of
the
active
ingredient
in
the
product.
In
addition,
the
EPA
Reg.
No.
of
the
product,
the
name
of
the
current
registrant,
and
the
EPA
Reg.
No.
of
the
source
product
must
be
updated.
We
further
note
that
the
nominal
concentration
of
the
source
product
has
been
increased;
therefore,
the
label
claim
of
the
repackaged
product
must
be
revised.
14
AGENCY
MEMORANDA
CITED
IN
THIS
DOCUMENT
DP
Barcode(
s):
D166724
Subject:
FMC
Response
to
the
Phase
IV
DCI:
Product
Chemistry
Data;
Chemical
No.
109702.
From:
C.
Olinger
To:
V.
Dutch
Dated:
9/
2/
92
MRID(
s):
41887001
through
41887003
DP
Barcode(
s):
D183295
and
D183294
Subject:
Cypermethrin;
Product
Chemistry
Data.
From:
D.
McNeilly
To:
V.
Dutch
Dated:
2/
4/
93
MRID(
s):
42043801
and
42068501
DP
Barcode(
s):
RD
Memorandum;
D225261
Subject:
Product
Chemistry
Review;
Reg./
File
Symbol
No.
10182­
68;
Product
Name:
Cypermethrin
Technical;
Company:
Zeneca
Ag
Products.
From:
S.
Mathur
To:
G.
LaRocca
Dated:
4/
25/
96
MRID(
s):
None
DP
Barcode(
s):
RD
Memorandum;
D277093
Subject:
Product
Chemistry
Review
of
Cypermethrin
Technical
Insecticide.
From:
S.
Mathur
To:
A.
Layne
Dated:
10/
31/
01
MRID(
s):
45462101,
45462102,
and
45474201
DP
Barcode(
s):
RD
Memorandum;
D280344
Subject:
Product
Chemistry
Review
of
TGAI/
MP;
Reg./
File
Symbol
No.
70506­
RN;
Product
Name:
Cypermethrin
Technical
Insecticide;
Company:
United
Phosphorous
Incorporation.
From:
S.
Mathur
To:
A.
Layne
Dated:
4/
23/
02
15
MRID(
s):
None
DP
Barcode(
s):
RD
Memorandum;
D285776
Subject:
Product
Chemistry
Review;
Reg./
File
Symbol
No.:
279­
3026;
Product
Name:
Ammo
Technical
Insecticide.
From:
L.
Kutney
To:
A.
Layne,
L.
DeLuise
and
P.
Dobak
Dated:
10/
29/
02
MRID(
s):
None
DP
Barcode(
s):
Subject:
Product
Chemistry
Review
for
Zeneca
Ag
Products
90%
T
(
transferred
to
Syngenta
Crop
Protection,
EPA
Reg.
No.
100­
989).
From:
To:
Dated:
Under
Review
MRID(
s):
42854301
DP
Barcode(
s):
Subject:
Product
Chemistry
Review
for
FMC
Corp.
94%
T,
EPA
Reg.
No.
279­
3026.
From:
To:
Dated:
Under
Review
MRID(
s):
42650601,
42868201,
42868202,
and
45850201
PRODUCT
CHEMISTRY
CITATIONS
Bibliographic
citations
include
only
MRIDs
containing
data
which
fulfill
data
requirements.

References
(
cited):

00081566
Eitelman,
S.
J.;
Cheplen,
J.
M.
(
1981)
Characterization
of
Typical
Cypermethrin
Technical
Manufactured
by
ICI
Americas
Inc.:
Report
Series
TMU0557/
C.
(
Unpublished
study
received
Sep
10,
1981
under
10182­
EX­
19;
submitted
by
ICI
Americas,
Inc.,
Wilmington,
Del.;
CDL:
070289­
B)
16
00086966
ICI
Americas,
Incorporated
(
1981)
Confidential
Statement
of
Formula:
Cymbush
3E.
(
Unpublished
study
received
Nov
5,
1981
under
10182­
EX­
25;
CDL:
246211­
A)

00090032
ICI
Americas,
Incorporated
(
1981)
Manufacturing
Process.
(
Unpublished
study
received
Dec
30,
1981
under
10182­
64;
CDL:
070563­
D)

00097865
ICI
Americas,
Incorporated
(
1981)
[
Composition
and
Manufacturing
Process
of
Cymbush
®
Insecticide].
(
Unpublished
study
received
Dec
30,
1981
under
10182­
64;
CDL:
070556­
F)

00097866
ICI
Americas,
Incorporated
(
1981)
Confidential
Statement
of
Formula:
Cymbush
3E.
(
Unpublished
study
received
Dec
30,
1981
under
10182­
64;
CDL:
070556­
G)

00097868
ICI
Americas,
Incorporated
(
1981)
[
Cypermethrin:
Composition
and
Manufacturing
Process].
(
Unpublished
study
received
Dec
30,
1981
under
10182­
64;
CDL:
070557­
D)

00097869
ICI
Americas,
Incorporated
(
1981)
Confidential
Statement
of
Formula:
Cymbush
2E
(
JF
6670).
(
Unpublished
study
received
Dec
30,
1981
under
10182­
64;
CDL:
070557­
E)

00102991
ICI
Americas,
Inc.
(
1980)
[
Cypermethrin:
Chemical
Study].
(
Compilation;
unpublished
study
received
May
20,
1982
under
10182­
68;
CDL:
247563­
A)

00115281
FMC
Corp.
(
1982)
Product
Chemistry:
[
Ammo
Technical
and
Ammo
2.5
EC
Formulation].
(
Compilation;
unpublished
study
received
Oct
1,
1982
under
279­
3026;
CDL:
248522­
A)

00133028
FMC
Corp.
(
1983)
Product
Chemistry:
[
Ammo].
(
Compilation;
unpublished
study
received
Dec
20,
1983
under
279­
3027;
CDL:
252014­
A)

00161909
FMC
Corp.
(
1984)
Product
Chemistry
for
Ammo
2.5
Oil,
Ammo
2.5
EC,
and
Ammo
Technical.
Unpublished
compilation.
28
p.

40513301
Ierley,
D.
(
1988)
Product
Chemistry
Data
Summary:
Cymbush
2E
Insecticide.
Unpublished
compilation
prepared
by
ICI
Americas,
Inc.
13
p.

41887001
Smeltz,
L.
(
1991)
Cypermethrin:
Product
Identity
and
Disclosure
of
Ingredients;
Description
of
Starting
Materials
and
Manufacturing
Process;
Discussion
of
the
Formation
of
Impurities:
Lab
Project
Number:
191D61P90­
1:
P­
2572.
Unpublished
study
prepared
by
FMC
Corp.
121
p.

41887002
Smeltz,
L.
(
1991)
Cypermethrin:
Analysis
and
Certification
of
Product
Ingredients:
Lab
Project
Number:
191D61P90­
1:
P­
2573.
Unpublished
study
prepared
by
FMC
Corp.
152
p.
17
41887003
Alvarez,
M.
(
1991)
Cypermethrin:
Physical
Properties
of
Cypermethrin:
Lab
Project
Number:
P­
2594:
191AF90195.
Unpublished
study
prepared
by
FMC
Corp.
50
p.

42043801
Fox,
D.
(
1991)
Analysis
and
Certification
of
Product
Ingredients
in
Cypermethrin
Technical:
Lab
Project
Number:
APP­
010:
RR
91­
066B.
Unpublished
study
prepared
by
ICI
Americas
Inc.,
Western
Research
Center.
365
p.

42068501
Kahn,
B.;
Wilks,
K.
(
1991)
Description
of
Beginning
Materials
and
Manufacturing
Process
and
Discussion
of
the
Formation
of
Impurities
for
Cypermethrin
Technical:
Lab
Project
Number:
RR/
91/
063B.
Unpublished
study
prepared
by
ICI
Americas,
Western
Research
Center.
116
p.

42650601
FMC
Corp.
(
1993)
Response
to
the
EPA's
Review
of
MRID
41887003:
Cypermethrin
Product
Chemistry.
Unpublished
study.
6
p.

42854301
Wilks,
K.
(
1993)
Description
of
Beginning
Materials
and
Manufacturing
Process
and
Discussion
of
the
Impurities
for
Cypermethrin
Technical:
Supplemental
Information/
Data:
Lab
Project
Number:
RR
91­
063B
ADD
1.
Unpublished
study
prepared
by
Zeneca
Ag
Products.
10
p.

42868201
Alvarez,
M.
(
1993)
Response
to
Questions
Raised
by
EPA
Regarding
MRID
41887003
Cypermethrin
Product
Chemistry.
Unpublished
study
prepared
by
FMC
Corp.
7
p.

42868202
Alvarez,
M.
(
1993)
Evaluation
of
Additional
Physical
Properties
of
Cypermethrin
Technical:
Lab
Project
Number:
191AF92239:
P­
2844.
Unpublished
study
prepared
by
FMC
Corp.
34
p.

45462101
Brown,
E.
(
2001)
Cypermethrin
Technical
Insecticide:
Product
Identity,
Composition,
and
Analysis:
Lab
Project
Number:
UPI­
CYPERTECH­
A:
2254:
3270.
Unpublished
study
prepared
by
Jai
Research
Foundation.
421
p.

45474201
Brown,
E.
(
2001)
Cypermethrin
Technical
Insecticide:
Physical
and
Chemical
Properties
(
Group
B):
Lab
Project
Number:
UPI­
CYPERTECH­
B:
2367:
2366.
Unpublished
study
prepared
by
Jai
Research
Foundation.
153
p.

45850201
Smeltz,
L.
(
2003)
Analysis
of
Cypermethrin
Technical:
Lab
Project
Number:
ATM­
0418:
210:
291.
Unpublished
study
prepared
by
FMC
Corporation.
75
p.
18
CYPERMETHRIN
PC
Code
109702;
Case
No.
2130
Reregistration
Eligibility
Decision:
Residue
Chemistry
Considerations
May
29,
2000
Contract
No.
68­
W­
99­
053
Submitted
to:
U.
S.
Environmental
Protection
Agency
Arlington,
VA
Submitted
by:
Dynamac
Corporation
1910
Sedgwick
Road
Building
100,
Suite
B
Durham,
NC
27713
CYPERMETHRIN
REREGISTRATION
ELIGIBILITY
DECISION
RESIDUE
CHEMISTRY
CONSIDERATIONS
PC
Code
109702;
Case
No.
2130
TABLE
OF
CONTENTS
page
INTRODUCTION
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1
REGULATORY
BACKGROUND
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1
SUMMARY
OF
SCIENCE
FINDINGS
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2
OPPTS.
GLN
860.1200:
Directions
for
Use
.
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2
OPPTS.
GLN
860.1300:
Nature
of
the
Residue
­
Plants
.
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9
OPPTS.
GLN
860.1300:
Nature
of
the
Residue
­
Livestock
.
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9
OPPTS.
GLN
860.1340:
Residue
Analytical
Methods
­
Plants
and
Livestock
.
.
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10
OPPTS.
GLN
860.1380:
Storage
Stability
Data
.
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10
OPPTS.
GLN
860.1500:
Crop
Field
Trials
.
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11
OPPTS.
GLN
860.1520:
Processed
Food/
Feed
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11
OPPTS.
GLN
860.1460:
Food­
Handling
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11
OPPTS.
GLN
860.1480:
Meat/
Milk/
Poultry/
Eggs
.
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12
OPPTS.
GLN
860.1400:
Water,
Fish,
and
Irrigated
Crops
.
.
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15
OPPTS.
GLNs
860.1850/
1900:
Confined/
Field
Accumulation
in
Rotational
Crops
.
.
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15
TOLERANCE
REASSESSMENT
SUMMARY
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19
Tolerances
Listed
Under
40
CFR
§
180.418(
a)(
1)
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19
Tolerances
That
Need
To
Be
Proposed
Under
40
CFR
§
180.418(
a)(
1)
.
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19
CODEX
HARMONIZATION
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21
AGENCY
MEMORANDA
RELEVANT
TO
REREGISTRATION
.
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23
CYPERMETHRIN
REREGISTRATION
ELIGIBILITY
DECISION
RESIDUE
CHEMISTRY
CONSIDERATIONS
PC
Code
109702;
Case
No.
2130
INTRODUCTION
Cypermethrin
[(
±
)
­
alpha­
3­
cyano­(
3­
phenoxyphenyl)
methyl
[(
±
)
­
cis,
trans­
3(
2,2­
dichloroethenyl
2,2­
dimethylcyclopropanecarboxylate]]
is
a
stomach
and
contact
insecticide
belonging
to
the
pyrethroid
family
of
pesticides.
Cypermethrin
is
registered
for
foliar
applications
to
control
a
wide
range
of
pests,
particularly
lepidoptera,
on
food/
feed
crops
including
leafy
Brassica
greens
and
head
and
stem
Brassica
crop
subgroups,
cotton,
garlic,
lettuce
(
head),
onions
(
dry
bulb
&
green),
pecans,
and
shallots
using
ground,
sprinkler
irrigation,
or
aerial
equipment.
Cypermethrin
is
additionally
registered
for
indoor
applications
(
e.
g.,
spot
or
crack
and
crevice
treatments)
to
commercial
food­
handling
establishments
using
brush
or
spray
equipment.
The
single
active
ingredient
formulations
of
cypermethrin
include
the
emulsifiable
concentrate
(
EC),
the
soluble
concentrate/
liquid
(
SC/
L),
and
the
wettable
powder
(
WP).
Cypermethrin
is
compatible
with
a
number
of
insecticides
and
fungicides.
Cypermethrin
is
classified
as
a
restricted­
use
pesticide
(
RUP)
for
some
of
its
applications.

REGULATORY
BACKGROUND
The
Cypermethrin
Phase
4
Review
was
issued
2/
11/
91.
A
Data­
Call­
In
(
DCI)
Notice
was
issued
7/
1/
91
requiring
the
registrants
to
submit
several
residue
chemistry
studies
for
cypermethrin
in
order
to
fulfill
reregistration
requirements.
The
basic
producers,
FMC
Corporation
and
Zeneca
Ag
Products
(
formerly
ICI
Americas),
have
submitted
several
of
the
studies
requested
in
the
DCI,
and
the
majority
of
these
studies
have
undergone
Phase
5
Review.
The
data
requirements
for
a
few
studies
still
remain
unfulfilled.
The
Residue
Chemistry
Chapter
for
the
Cypermethrin
Reregistration
Eligibility
Decision
(
RED)
Document
was
completed
on
9/
12/
96.
This
document
represents
a
revision
of
the
RED
Chapter,
and
summarizes
the
current
Residue
Chemistry
Science
Assessments
with
respect
to
the
reregistration
of
cypermethrin.

Permanent
tolerances
expressed
in
terms
of
the
residues
cypermethrin
per
se
are
established
under
40
CFR
§
180.418(
a)(
1)
for
pecans
(
0.05
ppm);
bulb
onions
(
0.10
ppm);
cottonseed
(
0.5
ppm);
head
and
stem
brassica
(
2.0
ppm);
green
onions
(
6.0
ppm);
head
lettuce
(
10.0
ppm);
leafy
brassica
(
14.0
ppm);
and
for
the
milk,
fat,
meat,
and
meat
byproducts
of
cattle,
goats,
hogs,
horses,
and
sheep
(
each
at
0.05
ppm).
No
tolerances
have
been
established
for
processed
crop
commodities.
Adequate
methods
are
available
for
the
enforcement
of
established
tolerances.
2
FMC
Corporation
has
registered
zeta­
or
S­
cypermethrin,
which
is
the
resolved
active
isomer
of
RS­
cypermethrin.
Since
the
active
isomer
is
enhanced
and
no
longer
a
racemic
mixture,
Scypermethrin
is
considered
a
new
pesticide
active
ingredient
(
PC
Code
129064).
Tolerances
for
residues
of
zeta­
cypermethrin
(
S­
cyano(
3­
phenoxyphenyl)
methyl
[(
±
)
­
cis,
trans­
3(
2,2­
dichloroethenyl)­
2,2­
dimethylcyclopropane­
carboxylate)
and
its
inactive
R­
isomers
have
been
established
under
40
CFR
§
180.418(
a)(
2)
for
a
wide
variety
of
crops.

Additional
cypermethrin
residue
data
are
now
required
for
cotton
gin
byproducts
as
a
result
of
changes
to
OPPTS.
GLN
860.1000,
Table
1
(
8/
96).
The
new
data
requirement
was
imposed
at
the
issuance
of
the
Cypermethrin
RED
(
9/
96),
but
will
not
impinge
on
the
current
reregistration
eligibility
decisions
for
cypermethrin.
The
appropriate
tolerance
level
for
cotton
gin
byproducts
and
the
need
for
any
revisions
to
dietary
exposure/
risk
assessments
will
be
determined
upon
receipt
of
the
required
residue
chemistry
data.

SUMMARY
OF
SCIENCE
FINDINGS
OPPTS.
GLN
860.1200:
Directions
for
Use
A
REFS
search
conducted
2/
9/
00
identified
14
cypermethrin
end­
use
products
(
EPs)
registered
to
FMC
Corporation
and
Syngenta
Crop
Protection,
Inc.,
under
FIFRA
Section
3,
and
five
active
SLNs
registered
under
FIFRA
Section
24(
c)
for
use
on
food/
feed
crops.
A
list
of
cypermethrin
EPs
is
presented
in
the
table
below.
A
comprehensive
summary
of
registered
food/
feed
use
patterns
for
cypermethrin,
based
on
the
products
registered
to
the
basic
producers
and
all
active
SLN
registrations
is
presented
in
Table
A.
For
the
purposes
of
reregistration,
label
amendments
are
required
for
cypermethrin
EPs
with
use
claims
on
garlic,
lettuce,
onions,
and
pecans
to
specify
minimum
retreatment
intervals.
In
addition,
several
product
labels
allow
application
in
less
than
2
gal/
A
when
using
aerial
equipment.
Unless
the
registrants
submit
field
residue
data
to
support
aerial
applications
in
<
2
gal/
A,
the
product
labels
must
be
amended
to
specify
that
aerial
applications
be
made
in
a
minimum
of
2
gal/
A.
Finally,
all
cypermethrin
and
zeta­
cypermethrin
labels
pertaining
to
agricultural
crops
should
contain
the
following
restriction:
"
do
not
apply
cypermethrin
products
to
crops
that
have
been
treated
with
zeta­
cypermethrin
or
vice
versa."

Non­
food
uses:
Cypermethrin
is
registered
under
FIFRA
Section
24(
c)
for
use
on
Bermuda
grass
grown
for
seed
(
AZ840006
and
CA840214),
clover
grown
for
seed
(
CA850044),
and
dry
bulb
onion
grown
for
seed
(
AZ930009).
The
labels
for
these
SLNs
specify
that
the
grazing
or
feeding
of
treated
foliage,
crop
residue,
or
seed
millings
is
prohibited.
HED
has
examined
the
product
labels
for
these
SLN
uses
and
concluded
that
these
are
non­
food/
feed
uses
based
on
the
application
timing
and
accompanying
label
restrictions.
Therefore,
field
trial
data
are
not
required
to
support
these
uses.

The
registrants
have
appropriately
amended
their
labels,
as
requested
in
the
Phase
4
Review,
to
clarify
cypermethrin
uses
in
greenhouses
and
warehouses
where
raw
or
cured
tobacco
may
be
stored.
Because
cypermethrin
uses
in
greenhouses
are
now
limited
to
ornamental
plants,
no
data
3
depicting
the
magnitude
of
the
residue
in/
on
food/
feed
crops
grown
under
greenhouse
conditions
are
required.
Furthermore,
because
label
directions
for
use
of
cypermethrin
in
warehouses
explicitly
prohibit
applications
when
raw
or
cured
tobacco
is
stored,
residue
data
for
tobacco
stored
in
warehouses
are
no
longer
required.

Cypermethrin
end­
use
products
(
EPs)
with
food/
feed
uses
registered
to
FMC
Corporation
and
Syngenta
Crop
Protection,
Inc.

Registrant
EPA
Reg.
No.
Acceptance
Date
Formulation
Class
Product
Name
FMC
Corporation
279­
3027
a
3/
99
2.5
lb/
gal
EC
Ammo
®
2.5
EC
Insecticide
279­
3044
6/
95
2.5
lb/
gal
SC/
L
Ammo
®
2.5
Oil
Insecticide
279­
3046
6/
95
2.5
lb/
gal
EC
Ammo
®
2.5
Miscible
Insecticide
279­
3070
9/
96
40%
WP
Cynoff
®
WP
Insecticide
279­
3081
9/
96
2
lb/
gal
EC
Cynoff
®
EC
Insecticide
279­
3082
5/
98
2
lb/
gal
EC
Prevail
®
FT
Termiticide
279­
3084
10/
96
38.7%
WP
Ammo
®
WSB
Insecticide
279­
3085
9/
96
35.6%
WP
Cynoff
®
WSB
Insecticide
in
Water
Soluble
Bags
279­
3109
9/
96
50%
WP
Cynoff
®
50
WP
Insecticide
279­
3117
9/
96
50%
WP
Cynoff
®
50
WSB
Insecticide
279­
3120
8/
95
2.5
lb/
gal
EC
Cynoff
®
2.5
EW
Insecticide
Syngenta
Crop
Protection
Inc.

100­
71
9/
97
40%
WP
Demon
®
WP
Insecticide
100­
100
2/
98
35.6%
WP
Demon
®
WP
Insecticide
in
Water
Soluble
Packets
100­
105
9/
97
2
lb/
gal
EC
Demon
®
EC
Insecticide
a
Including
SLN
Nos.
AL940008,
AZ930009,
LA940002,
MS940004,
and
NM860002.

A
tabular
summary
of
the
residue
chemistry
science
assessments
for
reregistration
of
cypermethrin
is
presented
in
Table
B.
The
conclusions
listed
in
Table
B
regarding
the
reregistration
eligibility
of
cypermethrin
food/
feed
uses
are
based
on
the
use
patterns
registered
by
the
basic
producers,
FMC
and
Syngenta.
When
end­
use
product
DCIs
are
developed
(
e.
g.,
at
issuance
of
the
RED),
RD
should
require
that
all
end­
use
product
labels
(
e.
g.,
MAI
labels,
SLNs,
and
products
subject
to
the
generic
data
exemption)
be
amended
such
that
they
are
consistent
with
the
basic
producer
labels.
4
(
Continued;
footnotes
follow)

Table
A.
Food/
Feed
Use
Patterns
Subject
to
Reregistration
for
Cypermethrin
(
Case
No.
2130).

Site
Application
Type
Application
Timing
Application
Equipment
Formulation
[
EPA
Reg.
No.]
Maximum
Single
Appl.
Rate
(
ai)
Maximum
Number
of
Applications
Minimum
Retreatment
Interval
(
Days)
Use
Limitations
1
Cotton
Foliar
broadcast
application
Ground,
sprinkler
irrigation,

or
aerial
equipment
2.5
lb/
gal
EC
[
279­
3027]

[
279­
3046]

2.5
lb/
gal
SC/
L
[
279­
3044]
0.1
lb/
A
NS
3
(
for
boll
weevil
control)
Applications
may
be
made
in
water
or
refined
vegetable
oil.
When
using
water,
applications
may
be
made
in
a
minimum
of
5
gal/
A
using
ground
equipment
or
1
gal/
A
using
aerial
equipment.
One
quart
of
emulsified
oil
(
minimum)
may
be
substituted
for
one
quart
of
water
in
aerial
applications.
When
using
oil,

applications
may
be
made
in
a
minimum
of
1
qt/
A.
Applications
may
be
made
alone
or
as
a
tank
mix
with
other
products
approved
for
use
on
cotton.
The
grazing
or
feeding
of
cotton
forage
is
prohibited.
A
14­
day
PHI
and
a
1­

day
REI
have
been
established.
A
maximum
seasonal
rate
of
0.6
lb
ai/
A
is
in
effect.

Foliar
broadcast
application
Ground,
sprinkler
irrigation,

or
aerial
equipment
38.7%
WP
[
279­
3084]
0.1
lb/
A
NS
3
(
for
boll
weevil
control)
Applications
may
be
made
in
water
only
in
a
minimum
of
5
gal/
A
using
ground
or
aerial
equipment.
The
grazing
or
feeding
of
cotton
forage
is
prohibited.
A
14­
day
PHI
and
a
1­

day
REI
have
been
established.
A
maximum
seasonal
rate
of
0.6
lb
ai/
A
is
in
effect.
Table
A
(
continued).

Site
Application
Type
Application
Timing
Application
Equipment
Formulation
[
EPA
Reg.
No.]
Maximum
Single
Appl.
Rate
(
ai)
Maximum
Number
of
Applications
Minimum
Retreatment
Interval
(
Days)
Use
Limitations
1
5
(
continued;
footnotes
follow)

Cotton
(
continued)

Soil
broadcast,
band,
or
in­
furrow
spray
application
Preplant
to
crop
emergence
Ground
or
aerial
equipment
38.7%
WP
[
279­
3084]

2.5
lb/
gal
EC
[
279­
3027]

[
279­
3046]

[
AL940008]

[
LA940002]

[
MS940004]

[
SC950008]

2.5
lb/
gal
SC/
L
[
279­
3044]
0.1
lb/
A
NS
NS
Applications
may
be
made
in
a
minimum
of
1
gal/
A
by
air
(
5
gal/
A
by
air
for
the
38.7%
WP
formulation).
The
grazing
or
feeding
of
cotton
forage
is
prohibited.
A
14­
day
PHI
has
been
established.
A
maximum
seasonal
rate
of
0.6
lb
ai/
A
is
in
effect.

Head
and
stem
Brassica
sub
group
Foliar
broadcast
application
Ground
or
aerial
equipment
38.7%
WP
[
279­
3084]

2.5
lb/
gal
EC
[
279­
3027]
0.1
lb/
A
NS
7
Applications
may
be
made
in
a
minimum
of
15
gal/
A
using
ground
equipment
or
5
gal/
A
using
aerial
equipment.
A
1­
day
PHI
and
a
1­
day
REI
have
been
established.
A
maximum
seasonal
rate
of
0.6
lb
ai/
A
is
in
effect.

Leafy
Brassica
Greens
sub
group
Foliar
broadcast
application
Ground
or
aerial
equipment
38.7%
WP
[
279­
3084]

2.5
lb/
gal
EC
[
279­
3027]
0.1
lb/
A
NS
7
Applications
may
be
made
in
a
minimum
of
15
gal/
A
using
ground
equipment
or
5
gal/
A
using
aerial
equipment.
A
1­
day
PHI
and
a
1­
day
REI
have
been
established.
A
maximum
seasonal
rate
of
0.4
lb
ai/
A
is
in
effect.
Table
A
(
continued).

Site
Application
Type
Application
Timing
Application
Equipment
Formulation
[
EPA
Reg.
No.]
Maximum
Single
Appl.
Rate
(
ai)
Maximum
Number
of
Applications
Minimum
Retreatment
Interval
(
Days)
Use
Limitations
1
6
(
continued;
footnotes
follow)

Lettuce,
head
Foliar
broadcast
application
Ground
or
aerial
equipment
38.7%
WP
[
279­
3084]

2.5
lb/
gal
EC
[
279­
3027]
0.1
lb/
A
NS
NS
Applications
may
be
made
in
a
minimum
of
15
gal/
A
using
ground
equipment
or
5
gal/
A
using
aerial
equipment.
A
5­
day
PHI
and
a
1­
day
REI
have
been
established.
A
maximum
seasonal
rate
of
0.6
lb
ai/
A
is
in
effect.

Onion,
bulb
(
including
garlic
and
shallots)

Foliar
broadcast
application
Ground
or
aerial
equipment
38.7%
WP
[
279­
3084]

2.5
lb/
gal
EC
[
279­
3027]
0.1
lb/
A
NS
NS
Applications
may
be
made
in
a
minimum
of
20
gal/
A
using
ground
equipment
or
3
gal/
A
using
aerial
equipment.
The
grazing
of
livestock
in
treated
areas
or
cutting
of
treated
crops
for
feed
is
prohibited.
A
7­
day
PHI
and
a
1­
day
REI
have
been
established.
A
maximum
seasonal
rate
of
0.5
lb
ai/
A
is
in
effect.

Pecans
Foliar
broadcast
application
Pre­
shuck
split
Ground
equipment
38.7%
WP
[
279­
3084]

2.5
lb/
gal
EC
[
279­
3027]

[
NM860002]
0.1
lb/
A
NS
NS
Ground
applications
may
be
made
to
the
point
of
drip;
100
gal/
A
for
smaller
trees
and
200
to
300
gal/
A
for
larger
trees.
The
grazing
of
livestock
in
treated
orchards
or
cutting
of
treated
cover
crops
for
feed
is
prohibited.
A
21­
day
PHI
has
been
established.
A
maximum
seasonal
rate
of
0.6
lb
ai/
A
is
in
effect;
for
SLN
No.
NM860002,
a
maximum
seasonal
rate
of
0.8
lb
ai/
A
is
in
effect.
Table
A
(
continued).

Site
Application
Type
Application
Timing
Application
Equipment
Formulation
[
EPA
Reg.
No.]
Maximum
Single
Appl.
Rate
(
ai)
Maximum
Number
of
Applications
Minimum
Retreatment
Interval
(
Days)
Use
Limitations
1
7
Food­
Handling
Establishments
Spot
or
crack/
crevice
application
Brush
or
spray
equipment
35.6%
WP
[
279­
3085]

[
10182­
100]

40%
WP
[
279­
3070]

[
10182­
71]

50%
WP
[
279­
3109]

[
279­
3117]

2
lb/
gal
EC
[
279­
3081]

[
279­
3082]

[
10182­
105]

2.5
lb/
gal
EC
[
279­
3120]

3
lb/
gal
EC
[
10182­
106]
0.2%
NS
Not
applicable
(
NA)
Application
is
allowed
in
non­
food
areas
of
food­
handling
establishments
(
other
than
private
residences)
in
which
food
is
held,

processed,
prepared
or
served.

Use
in
food
areas
of
food
handling
establishments,
restaurants
or
other
areas
where
food
is
commercially
prepared
is
prohibited.
The
label
prohibits
use
in
serving
areas
while
food
is
exposed
or
facility
is
in
operation.
The
label
specifies
that
in
the
home
all
food
processing
surfaces
and
utensils
should
be
covered
during
treatment
or
thoroughly
washed
before
use;
exposed
food
should
be
covered
or
removed.

Application
in
warehouses
where
raw
or
cured
tobacco
is
stored,
or
while
raw
agricultural
commodities
for
food
or
feed
are
being
stored
is
prohibited.
Applications
may
be
repeated
as
necessary.

Spot
or
crack/
crevice
application
Brush
or
spray
equipment
3
lb/
gal
EC
[
10182­
108]
0.1%
NS
NA
Applications
may
be
repeated
as
necessary.
8
1.
REI
=
Reentry
interval
and
PHI
=
Preharvest
interval.
Rotational
crops
may
be
planted
30
days
after
the
last
application
of
the
2.5
lb/
gal
EC
(
EPA
Reg.

Nos.
279­
3027
and
279­
3046),
2.5
lb/
gal
SC/
L
(
EPA
Reg.
No.
279­
3044),
or
38.7%
WP
(
EPA
Reg.
No.
279­
3084)
formulations.
9
OPPTS.
GLN
860.1300:
Nature
of
the
Residue
­
Plants
The
qualitative
nature
of
the
residue
in
plants
is
adequately
understood
based
on
acceptable
plant
metabolism
studies
with
lettuce,
corn,
and
cotton
plants.
These
studies
identified
several
metabolites
at
varying
concentrations.
The
main
route
of
metabolism
is
hydrolysis
of
the
ester
linkage
and
further
oxidation
of
the
alcohol
and
acid
hydrolysates.

The
Metabolism
Assessment
Review
Committee
(
MARC)
determined
that
the
residue
of
concern
for
enforcement
and
dietary
risk
assessment
purposes
is
zeta­
cypermethrin
plus
the
four
inactive
Risomers
in
plants,
livestock,
and
drinking
water
(
D269584,
Y.
Donovan,
03­
NOV­
2000).
Thus,
the
current
tolerance
expression
for
plants
is
adequate.
Also,
the
MARC
determined
that
the
residues
of
the
metabolite
dichlorovinyl
acid
(
DCVA)
(
cis
and
trans)
need
not
be
included
in
the
tolerance
expression
or
risk
assessment
for
cypermethrin
and
zeta­
cypermethrin.
This
determination
was
based
on
the
observation
that
in
the
majority
of
crops,
parent
compound
accounts
for
at
least
90%
of
the
total
residue.
In
those
crops
where
DCVA
was
found
>
10%,
either
the
detected
DCVA
levels
were
below
the
LOQ
or
the
maximum
animal
dietary
burden
contributions
from
DCVA
for
these
commodities
were
about
equal
to
or
less
than
the
LOQ.
Thus,
this
decision
regarding
DCVA
is
limited
to
cypermethrin
and
zeta­
cypermethrin
only
as
toxicity
concerns
for
DCVA
remain.
Other
pyrethroid
insecticides
which
generate
DCVA
should
be
examined
individually
with
respect
to
DCVA
regulation.
Regulation
of
the
parent
only
is
consistent
with
CODEX
and
eases
enforcement,
since
DCVA
is
not
recovered
by
the
multi­
residue
enforcement
methods.
The
chemical
structures
of
cypermethrin
and
DCVA
are
depicted
in
Figure
A.

Figure
A.
Chemical
structures
of
cypermethrin
and
DCVA.

Compound:
Chemical
name
Compound:
Chemical
name
Cypermethrin
[(
±
)
­
alpha­
cyano­(
3­
phenoxyphenyl)
methyl
[(
±
)
­
cis,
trans­
3(
2,2­
dichloroethenyl)­
2,2­
dimethylcyclopropanecarboxylate
DCVA:
1­(
RS)­
cis­
trans­
3­(
2,2­
dichlorovinyl)­
2,2­
dimethylcyclopropanecarboxylic
acid
10
OPPTS.
GLN
860.1300:
Nature
of
the
Residue
­
Livestock
The
qualitative
nature
of
the
residue
in
ruminants
and
poultry
is
adequately
understood.
The
HED
MARC
has
determined
that
the
residue
to
be
regulated
in
livestock
commodities
is
cypermethrin
per
se;
thus,
the
current
tolerance
expression
for
livestock
commodities
is
appropriate.

The
major
metabolites
identified
in
tissues,
milk,
and
eggs
following
oral
administration
of
[
cyclopropyl­
14C]
cypermethrin
were
nonconjugated
cis­
and
trans­
DCVA
and
cypermethrin.
The
proposed
major
route
of
cypermethrin
metabolism
in
livestock
is
via
hydrolysis
of
the
ester
linkage.
Hydrolysis
of
the
benzyl­
labelled
cypermethrin
and/
or
its
hydroxylated
metabolites
gives
initially
the
unstable
cyanohydrin
which
rapidly
breaks
down
to
3­
phenoxybenzaldehyde
and
is
oxidized
to
the
corresponding
acid/
or
hydroxylated
acids.
A
very
minor
route
was
observed
in
which
a
small
amount
of
the
aldehyde
was
converted
to
its
corresponding
alcohol.

OPPTS.
GLN
860.1340:
Residue
Analytical
Methods
­
Plants
and
Livestock
No
additional
information
regarding
residue
analytical
methods
is
required.
The
Pesticide
Analytical
Manual
(
PAM)
Volume
II
lists
Methods
I
and
II
as
available
for
the
determination
of
residues
of
cypermethrin
per
se
in/
on
plant
and
livestock
commodities,
respectively.
Both
are
GLC
methods
with
electron
capture
detection
and
have
undergone
successful
Agency
method
tryout.
Method
I
has
a
detection
limit
of
0.01
ppm,
and
Method
II
has
detection
limits
of
0.005
ppm
for
milk
and
0.01
ppm
for
livestock
tissues.
These
methods
are
not
stereospecific;
thus
no
distinction
is
made
between
residues
of
cypermethrin
(
all
eight
stereoisomers)
and
zetacypermethrin
(
an
enriched
isomer
form
of
cypermethrin).

Revised
versions
of
the
livestock
methods
which
are
capable
of
determining
cypermethrin
and
DCVA
were
recently
validated
by
an
independent
laboratory.
Adequate
recoveries
were
obtained
by
the
laboratory.
The
revised
methods
were
also
subjected
to
a
successful
radiovalidation.
Methods
for
determination
of
DCVA
are
available
in
PAM
Volume
II
in
the
section
for
permethrin.

Multiresidue
method(
s):
The
1/
94
FDA
PESTDATA
database
indicates
that
residues
of
cypermethrin
are
completely
recovered
(>
80%)
using
multiresidue
method
Sections
302
(
Luke),
303
(
Mills,
Onley,
and
Gaither)
and
304
(
Mills
fatty
food).
Although
the
DCVA
metabolites
have
not
been
tested
through
FDA
multiresidue
methods,
the
recovery
of
these
metabolites
has
been
shown
to
be
unlikely.

OPPTS.
GLN
860.1380:
Storage
Stability
Data
Adequate
storage
stability
data
are
available
to
validate
the
maximum
storage
conditions
and
intervals
of
raw
agricultural
plant
commodity
samples
used
for
tolerance
establishment.
Additional
11
storage
stability
data
are
required
for
cottonseed
processed
products
(
for
a
minimum
interval
of
9
months).
Adequate
data
are
also
available
for
residues
in
milk,
eggs,
and
livestock
tissues.

The
existing
storage
stability
data
indicate
that
fortified
residues
of
cypermethrin
are
stable
under
frozen
storage
conditions
for
at
least
three
months
in
ruminant
liver
and
milk;
six
months
in
poultry
muscle,
liver,
and
eggs;
12
months
in
ruminant
muscle
and
fat;
18
months
in/
on
apples,
soybeans,
and
tomatoes;
30
months
in
broccoli
and
mustard
greens;
and
36
months
in
lettuce.

OPPTS.
GLN
860.1500:
Crop
Field
Trials
The
reregistration
requirements
for
magnitude
of
the
residue
in
plants
have
been
evaluated
and
deemed
fulfilled
for
the
following
raw
agricultural
commodities
(
RACs):
bulb
and
green
onions,
head
lettuce,
head
and
stem
Brassica
vegetables,
leafy
Brassica
vegetables,
pecans,
and
cottonseed.
Overall,
acceptable
field
trials
were
performed
representing
the
maximum
registered
use
patterns
and
conditions
under
which
the
pesticide
could
be
applied.
The
geographic
representation
for
each
commodity
is
generally
adequate,
and
a
sufficient
number
of
trials
reflecting
representative
formulation
classes
were
conducted.

Cypermethrin
is
currently
registered
for
use
on
garlic
and
shallots.
The
existing
tolerances
for
residues
in/
on
bulb
onions
and
green
onions
will
cover
the
registered
uses
of
cypermethrin
on
garlic
and
shallots,
respectively,
as
permitted
according
to
40
CFR
§
180.1(
h).

According
to
Table
1
of
the
OPPTS.
GLN
860.1500
(
8/
96),
cotton
gin
byproducts
are
now
recognized
as
a
raw
agricultural
commodity
of
cotton.
Therefore,
field
residue
data
must
be
submitted
for
cotton
gin
byproducts,
and
a
tolerance
must
be
proposed
for
this
commodity
when
adequate
field
residue
data
have
been
submitted.

OPPTS.
GLN
860.1520:
Processed
Food/
Feed
The
reregistration
requirements
for
magnitude
of
the
residue
in
the
processed
food/
feed
commodities
of
cottonseed
are
fulfilled
pending
submission
of
supporting
storage
stability
data.
An
acceptable
cottonseed
processing
study
has
been
submitted
and
evaluated.
The
data
from
this
processing
study
indicate
that
residues
of
cypermethrin
per
se
do
not
concentrate
in
cottonseed
meal,
hulls,
and
refined
oil
processed
from
cottonseed
bearing
detectable
residues.
Therefore,
no
separate
tolerances
are
required
for
residues
in
cotton
processed
fractions
as
the
existing
tolerance
on
cottonseed
will
cover
any
residues
in
processed
fractions
of
cotton.

OPPTS.
GLN
860.1460:
Food­
Handling
12
Several
cypermethrin
formulations
remain
registered
for
use
in
non­
food/
feed
areas
of
foodhandling
establishments
and
warehouses.
Sufficient
restrictions
are
included
on
the
basic
producer
labels
so
that
exposure
to
food
and
feed
is
unlikely.
No
additional
data
are
required
to
support
the
existing
use
in
non­
food/
feed
areas
of
food
handling
establishments.

OPPTS.
GLN
860.1480:
Meat/
Milk/
Poultry/
Eggs
Ruminants
Residues
of
cypermethrin
can
occur
directly
and
indirectly
in
milk
and
livestock
tissues
as
a
result
of
the
registered
uses
of
the
pesticide.
Cypermethrin
is
presently
registered
for
direct
livestock
treatments
such
as
cattle
ear
tag
uses.
Residues
of
cypermethrin
may
also
occur
indirectly
in
milk
and
livestock
tissues
due
to
registered
uses
on
agricultural
crops,
some
of
which
may
be
used
as
livestock
feedstuffs.
Because
the
analytical
method
does
not
distinguish
between
residues
of
cypermethrin
and
zeta­
cypermethrin,
tolerance
levels
for
MMPE
commodities
should
be
the
same
for
cypermethrin
and
zeta­
cypermethrin.
In
light
of
label
restrictions
and
the
different
total
application
rates
between
formulations
containing
cypermethrin
and
zeta­
cypermethrin,
different
tolerance
levels
may
be
appropriate
for
some
plants,
such
as
green
onions.
Thus,
taking
into
account
uses
of
cypermethrin
and
zeta­
cypermethrin,
Table
1
presents
the
calculated
theoretical
dietary
burden
for
beef
and
diary
cattle,
based
on
a
reasonable
diet
of
livestock
feedstuffs
that
may
contain
cypermethrin
or
zeta­
cypermethrin
residues.

Table
1.
Calculated
theoretical
dietary
burdens
of
cypermethrin
and
zeta­
cypermethrin
from
various
feed
commodities
for
beef
and
dairy
cattle.

Feed
Commodity
Tolerance
level
(
ppm)
%
Dry
Matter
Beef
&
Dairy
Cattle
%
of
Diet
Acute
Anticipated
Dietary
Burden/
Chronic
Anticipated
Dietary
Burden
(
ppm)

Soybean
meal
0.05a
92
15
0.0082
Alfalfa
hay
15
89
25
4.21
Corn,
sweet,
forage
15
48
40
12.5
Rice
grain
1.5
88
10
0.17
Aspirated
Grain
Fraction
(
AGF)
10
85
10
1.18
Total
for
diet
100
18.1
a
Taken
as
soybean,
seed
tolerance
level.
13
The
available
ruminant
magnitude
of
residue
study
has
been
evaluated
and
found
to
be
adequate
to
satisfy
ruminant
feeding
study
data
requirements.
In
this
study,
one
group
of
Holstein
dairy
cows
was
fitted
with
eartags
containing
cypermethrin
(
7%
by
weight)
and
received
gelatin
capsules
without
cypermethrin.
Three
other
groups
were
fitted
with
eartags
containing
cypermethrin
and
orally
dosed
with
cypermethrin
in
gelatin
capsules
equivalent
to
5,
15,
and
50
ppm
in
the
diet
for
28
consecutive
days
equivalent
to
­

0.28x,
0.83x,
and
2.8x
the
maximum
dietary
burden
for
cattle
(
18.1
ppm).
The
residues
of
cypermethrin
found
in
ruminant
milk
and
tissues
are
summarized
in
Table
2.

Table
2.
Cypermethrin
residues
(
ppm)
in
milk
and
tissues
from
cows
fitted
with
eartags
and
dosed
daily
with
cypermethrin
at
levels
equivalent
to
5,
15,
and
50
ppm
in
the
diet
for
28
consecutive
days.

Oral
Dose
a
(
ppm)
Pectoral
Muscle
Adductor
Muscle
Peritoneal
Fat
Subcutaneous
Fat
Kidney
Liver
Whole
Milk
Milk
Cream
0
0.017
ND
b
0.017
ND
ND
ND
ND
0.010,0.016
(
0.013)
c
5
0.013
ND
0.101,0.150
(
0.126)
0.063,0.088
(
0.076)
0.012
ND
0.009,0.018
(
0.014)
ND
15
0.038,0.07
9
(
0.059)
0.014,0.041
(
0.028)
0.444,0.527
(
0.486)
0.315,0.462
(
0.389)
0.012,0.016
(
0.014)
ND
0.045,0.047
(
0.046)
0.214,0.314
(
0.264)

50
0.104,0.19
9
(
0.152)
0.028,0.041
(
0.035)
1.350,1.956
(
1.653)
0.737,0.993
(
0.865)
0.024,0.070
(
0.047)
ND
0.183,0.235
(
0.209)
0.663,1.009
(
0.836)

a
Livestock
in
each
dose
group
also
were
fitted
with
eartags
containing
cypermethrin
7%
w/
w.
b
ND
=
nondetectable
(<
0.002
ppm
for
whole
milk
samples;
<
0.010
ppm
for
tissue
and
milk
cream
samples).
c
Average
residue
in
parentheses.

Based
on
a
dietary
burden
of
18.1
ppm
and
the
results
of
the
bovine
feeding
study,
the
maximum
theoretical
levels
of
cypermethrin/
zeta­
cypermethrin
in/
on
beef
muscle,
fat,
kidney,
and
milk
are
0.083,
0.55,
0.017,
and
0.049
ppm,
respectively.
Thus,
the
appropriate
tolerance
levels
for
meat,
fat,
meat
byproducts
(
of
cattle,
goat,
sheep,
and
horse)
and
whole
milk
are
0.20,
1.0,
0.05,
and
0.10
ppm,
respectively.
The
current
milk
tolerance
for
zeta­
cypermethrin
is
expressed
as
follows:
"
Milk,
fat
(
reflecting
0.10
in
whole
milk)"
at
2.5
ppm.
This
expression
accounts
for
the
concentration
of
residues
in
milk
fat
and
is
also
appropriate
for
cypermethrin.
Note
that
although
a
tolerance
level
of
0.10
ppm
could
be
selected
for
meat,
a
level
of
0.20
ppm
is
chosen
to
achieve
harmony
with
the
Codex
MRL
and
the
established
meat
tolerance
level
for
zeta­
cypermethrin.

Poultry
and
Swine
In
a
similar
fashion,
the
calculated
theoretical
dietary
burden
of
cypermethrin
and
zetacypermethrin
for
poultry
and
swine
is
presented
in
Table
3.
14
Table
3.
Calculated
theoretical
dietary
burden
of
cypermethrin/
zeta­
cypermethrin
for
poultry
and
swine
Feed
Commodity
Tolerance
Level
(
ppm)
Poultry
Swine
%
Diet
Burden
(
ppm)
d
%
Diet
Burden
(
ppm)
d
Soybean
meal
0.05a
20
0.010
20
0.010
Rice
grain
1.5
30
0.45
40
0.60
Rice
bran
1.5b
20
0.30
15
0.23
Rice
hulls
6.0b
10
0.60
0
0
Corn,
field,
grain
0.010
20
0.002
15
0.0015
AGF
10
0
0
10
1.0
Total
100
1.4
100
1.8
a
Taken
as
soybean,
seed
tolerance
level.
b
Taken
as
rice,
grain
tolerance
level.

Based
on
a
dietary
burden
of
1.8
ppm
and
the
results
of
the
bovine
feeding
study,
the
maximum
theoretical
levels
of
cypermethrin/
zeta­
cypermethrin
in/
on
hog
muscle,
fat,
and
kidney
are
an
order
of
magnitude
less
than
those
for
cattle:
0.0083,
0.055,
and
0.0017
ppm,
respectively.
Because
the
LOQ
of
the
analytical
method
for
livestock
commodities
is
0.05
ppm,
the
appropriate
tolerance
levels
for
hog
meat
and
fat
are
0.05
and
0.10
ppm,
respectively.
No
tolerance
is
needed
for
hog,
meat
byproducts
due
to
the
low
levels
predicted
for
kidney
and
liver.
The
"
hog,
meat
byproducts"
tolerance
of
0.05
ppm
for
zeta­
cypermethin
should
be
removed.

The
available
poultry
feeding
study
is
adequate
to
satisfy
poultry
feeding
study
data
requirements.
In
the
poultry
feeding
study
(
Table
4),
three
groups
of
hens
were
dosed
orally
for
28
consecutive
days
with
cypermethrin
at
2,
6,
and
20
ppm
in
the
diet,
equivalent
to
1.4x,
4.3x,
and
14.3x
the
calculated
dietary
burden
(
1.4
ppm)
for
poultry.
After
Day
7,
cypermethrin
residues
in
whole
eggs
plateaued
at
<
0.005
ppm
(
nondetectable),
0.009
ppm,
and
0.026
ppm
for
the
three
respective
treatment
groups.
15
Table
4.
Residues
of
cypermethrin
(
ppm)
in
eggs
and
tissues
from
hens
dosed
daily
with
cypermethrin
at
levels
equivalent
to
2,
6,
and
20
ppm
in
the
diet
for
28
consecutive
days.

Dose
(
ppm)
Muscle
Fat
Kidney
Liver
Egg
Yolk
Whole
Egg
2
NA
a
ND­
0.016
(
0.016)
b
NA
NA
0.009­
0.010
(
0.009)
ND
6
NA
0.040­
0.086
(
0.064)
NA
NA
0.029­
0.037
(
0.033)
0.007­
0.010
(
0.009)

20
ND
c
0.134­
0.187
(
0.164)
ND
ND
0.067­
0.100
(
0.079)
0.017­
0.035
(
0.026)

a
Average
residue
in
parentheses.
b
NA
=
not
analyzed.
c
ND
=
nondetectable
(<
0.005
ppm
for
egg
samples;
<
0.010
ppm
for
tissue
samples).

Based
on
a
dietary
burden
of
1.4
ppm
and
the
results
of
the
poultry
feeding
study,
the
maximum
theoretical
levels
of
cypermethrin/
zeta­
cypermethrin
in/
on
poultry
muscle,
fat,
meat
byproducts
(
liver
and
kidney),
and
egg
are
<
0.0007,
0.020,
<
0.0007,
and
0.0086
ppm,
respectively.
Based
on
this
analysis,
no
tolerances
are
needed
for
poultry
meat
or
meat
byproducts.
However,
a
tolerance
level
of
0.05
ppm
is
appropriate
for
egg
and
poultry,
fat.
Although
the
present
analysis
suggest
that
no
tolerance
is
needed
for
poultry,
meat,
setting
a
level
of
0.05
ppm
for
this
commodity
would
maintain
harmony
with
the
Codex
MRL
and
the
zeta­
cypermethrin
tolerance
listing.
The
"
poultry,
meat
byproducts"
tolerance
of
0.05
ppm
for
zeta­
cypermethin
should
be
revoked.

OPPTS.
GLN
860.1400:
Water,
Fish,
and
Irrigated
Crops
Cypermethrin
is
presently
not
registered
for
direct
use
on
potable
water
or
aquatic
food
and
feed
crops;
therefore,
no
residue
chemistry
data
are
required
under
these
guideline
topics.

OPPTS.
GLNs
860.1850/
1900:
Confined/
Field
Accumulation
in
Rotational
Crops
An
acceptable
confined
rotational
study
has
been
submitted
(
MRID
00090064).
A
limited
field
rotational
crop
study
(
MRID
00098000)
has
been
submitted
and
deemed
adequate
by
EFGWB
to
fulfill
data
requirements
for
topic
OPPTS.
GLN
860.1900,
but
had
been
found
unacceptable
in
the
Phase
IV
review
because
the
soil
had
not
been
analyzed
for
cypermethrin.
The
most
recent
guidance
does
not
require
soil
analysis,
so
HED
considers
the
study
acceptable.
The
study
indicates
that
residues
of
cypermethrin
and
its
metabolites
were
non­
detectable
(<
0.01
ppm)
in/
on
the
rotational
crop
commodities
of
leafy
vegetables,
root
and
tuber
vegetables,
and
cereal
grain
crops
that
were
planted
30
days
after
the
soil
plots
were
treated
with
cypermethrin
at
0.5
lb
ai/
A
(­
5x
the
maximum
registered
single
application
rate).
The
submitted
study
supports
the
labelled
PBI
of
30
days
and
no
additional
rotational
crop
data
are
required
for
cypermethrin.
16
Table
B.
Residue
Chemistry
Science
Assessments
for
Reregistration
of
Cypermethrin.

GLN:
Data
Requirements
Current
Tolerances,
ppm
[
40
CFR
§
180.418]
Must
Additional
Data
Be
Submitted?
References
1
860.1200:
Directions
for
use
N/
A
=
Not
Applicable
Yes
2
See
Table
A
860.1300:
Nature
of
the
Residue­
Plants
N/
A
No
00125658
428763013
434213013
437751014
860.1300:
Nature
of
the
Residue­
Livestock
N/
A
No
00089014
41899802
5
424100013
42876302
3
860.1340:
Residue
Analytical
Methods
­
Plant
Commodities
N/
A
No
00090027
00090028
00125658
00127892
40880202
­
Livestock
Commodities
N/
A
No
00081571
432780033
437751034
437751044
437751054
437751064
437751074
437751084
860.1380:
Storage
Stability
Data
N/
A
Yes
6
920270567
421770018
435782019
435782029
437751094
437751104
860.1500:
Crop
Field
Trials
Bulb
Vegetables
Group
­
Onions,
dry
bulb
0.1
No
PP#
7F349810
­
Onions,
green
6.0
No
4351600111
Leafy
Vegetables
(
except
Brassica)
Group
­
Lettuce,
head
10
No12
00125658
00145249
435782039
Brassica
(
Cole)
Leafy
Vegetables
Group
­
Head
and
stem
Brassica
2.0
No
4300970113
435782049
435782059
­
Leafy
Brassica
14.0
No
4300970213
435782069
GLN:
Data
Requirements
Current
Tolerances,
ppm
[
40
CFR
§
180.418]
Must
Additional
Data
Be
Submitted?
References
1
17
1
Bolded
references
were
reviewed
in
the
Cypermethrin
Phase
4
Review,
2/
11/
91,
C.
Olinger.
All
other
references
were
reviewed
as
noted.

2
Label
amendments
are
required
for
cypermethrin
EPs
with
use
claims
on
lettuce,
onions,
and
pecans
to
specify
minimum
retreatment
intervals.
In
addition,
unless
the
registrant(
s)
have
field
residue
data
to
support
aerial
applications
in
<
2
gal/
A,
the
product
labels
must
be
amended
to
specify
that
aerial
applications
be
made
in
a
minimum
of
2
gal/
A.

The
restriction
against
grazing
or
feeding
cotton
forage
is
impracticable
and
must
be
removed
from
all
EP
Tree
Nuts
Group
­
Pecans
0.05
No
00131670
Miscellaneous
Commodities
­
Cottonseed
and
gin
byproducts
0.5
(
cottonseed)
Yes
14
00067376
00081574
00081575
00090027
00090046
00127892
00132000
00132828
40880202
43172001
15
860­
1520:
Processed
Food/
Feed
­
Cottonseed
­­
No
00067377
00090028
00090050
00132828
43270201
16
860.1480:
Meat/
Milk/
Poultry/
Eggs
­
Milk
and
the
Fat,
Meat,
and
Meat
Byproducts
of
Cattle,
Goats,
Hogs,
Horses,
and
Sheep
0.05
(
milk
and
the
fat,
meat,
and
mbyp
of
cattle,
goats,
hogs,
horses,
and
sheep)
No
43278002
3
­
Eggs
and
the
Fat,
Meat,
and
Meat
Byproducts
of
Poultry
None
established
No
43278001
3
860.1400:
Water,
Fish,
and
Irrigated
Crops
N/
A
N/
A
860.1460:
Food­
Handling
­­
No
860.1850:
Confined
Accumulation
in
Rotational
Crops
­­
No
00090064
17
860.1900:
Field
Accumulation
in
Rotational
Crops
­­
No
00098000
18
18
labels
with
uses
on
cotton
(
EPA
Reg.
Nos.
279­
3027,
­
3084,
­
3046,
and
­
3044).
3
CBTS
Memorandum,
Issues
to
be
Presented
to
the
HED
Metabolism
Committee,
5/
23/
95,
J.
Morales.

4
CBTS
No.
16178,
DP
Barcode
D219045,
J.
Stokes,
8/
07/
96.

5
CBRS
No.
8295,
DP
Barcode
D166726,
10/
5/
92,
C.
Olinger.

6
The
registrant
has
not
completely
responded
to
the
storage
stability
data
requirements
specified
in
the
Cypermethrin
Phase
4
Review.
Data
depicting
the
stability
of
residues
of
cypermethrin
per
se
are
required
for
cottonseed
processed
products,
for
a
minimum
interval
of
9
months.

7
The
title
of
MRID
92027056
indicates
that
it
is
a
Phase
3
summary
of
MRID
00071380
regarding
cypermethrin
storage
stability.
However,
MRID
00071380
does
not
pertain
to
cypermethrin.

8
CBRS
No.
9592,
DP
Barcode
D175749,
5/
20/
92,
W.
Anthony.

9
CBTS
No.
15355,
DP
Barcode
D213692,
J.
Stokes,
3/
05/
96.

10
CBTS
Nos.
11115
and
11116,
D186245,
3/
29/
93,
G.
Otakie.

11
CBTS
No.
15012,
DP
Barcode
D211325,
J.
Stokes,
2/
29/
96.

12
The
available
data
indicate
that
the
established
tolerance
for
lettuce
should
be
lowered
to
4.0
ppm.

13
CBTS
No.
13023,
DP
Barcode
D197868,
G.
Kramer,
8/
22/
94
14
Data
are
required
for
residues
of
cypermethrin
in/
on
cotton
gin
byproducts
harvested
at
normal
maturity
from
plants
treated
at
the
maximum
seasonal
application
rate.
Cotton
must
be
harvested
by
commercial
equipment
(
stripper
and
mechanical
picker)
to
provide
an
adequate
representation
of
plant
residue
for
the
ginning
process.
A
minimum
of
three
field
trials
for
each
type
of
harvesting
(
stripper
and
mechanical
picker)
are
required,
for
a
total
of
six
field
trials.
An
appropriate
tolerance
for
this
RAC
should
be
proposed
once
acceptable
data
have
been
submitted
and
evaluated.

15
CBTS
No.
15112,
DP
Barcode
D212111,
6/
20/
95,
J.
Stokes.

16
CBRS
No.
14107,
DP
Barcode
D205958,
10/
17/
94,
F.
Fort.

17
Reviewed
by
EFGWB
on
4/
29/
82.

18
Reviewed
by
EFGWB
on
5/
14/
82.
19
TOLERANCE
REASSESSMENT
SUMMARY
The
tolerances
listed
in
40
CFR
§
180.418(
a)(
1)
are
expressed
in
terms
of
residues
of
cypermethrin
per
se
[(
±
)
­
alpha­
cyano­(
3­
phenoxyphenyl)
methyl
[(
±
)
­
cis,
trans­
3(
2,2­
dichloroethenyl)­
2,2­
dimethylcyclopropanecarboxylate]],
while
those
listed
in
40
CFR
§
180.418(
a)(
2)
are
expressed
in
terms
of
residues
of
zeta­
cypermethrin
[(
S­
cyano­(
3­
phenoxyphenyl)
methyl
[(
±
)
­
cis,
trans­
3(
2,2­
dichloroethenyl)­
2,2­
dimethylcyclopropanecarboxylate]]
and
its
inactive
R­
isomers.
The
HED
MARC
has
determined
that
the
current
tolerance
expression
for
plant
and
livestock
commodities
is
appropriate.
Because
the
analytical
enforcement
method
does
not
distinguish
between
cypermethrin
and
zeta­
cypermethrin,
all
tolerance
levels
for
livestock
commodities
should
be
the
same
for
the
racemic
and
enriched
isomers.
In
light
of
label
restrictions
and
the
different
total
application
rates
between
formulations
containing
cypermethrin
and
zeta­
cypermethrin,
different
tolerance
levels
may
be
appropriate
for
some
plants,
such
as
green
onions.

Tolerances
Listed
Under
40
CFR
§
180.418(
a)(
1):

Plant
commodity
tolerances:
Sufficient
field
trial
data
are
available
to
ascertain
the
adequacy
of
the
established
tolerances
listed
in
40
CFR
§
180.418
for
the
following
plant
commodities:
head
and
stem
Brassica
subgroup;
leafy
greens
Brassica
subgroup;
undelinted
cottonseed;
head
lettuce;
bulb
onion;
green
onion;
and
pecans.
For
the
purposes
of
tolerance
reassessment,
the
existing
field
trial
data
for
these
RACs
have
been
re­
evaluated.
With
the
exception
of
head
lettuce,
the
data
suggest
that
the
existing
tolerance
levels
for
all
plant
commodities
are
appropriate,
and
no
increase
or
decrease
in
levels
are
warranted.
Based
on
acceptable
field
trial
data
for
head
lettuce,
the
established
tolerance
for
this
commodity
should
be
lowered
from
10
ppm
to
4.0
ppm.
The
available
data
indicate
that
the
maximum
residue
of
cypermethrin
found
in
head
lettuce
following
applications
of
a
representative
cypermethrin
formulation,
according
to
the
maximum
registered
patterns,
was
3.4
ppm.

Although
a
tolerance
for
garlic
has
not
been
established,
the
existing
tolerance
for
bulb
onions
will
cover
the
registered
uses
of
cypermethrin
on
garlic,
as
permitted
according
to
40
CFR
§
180.1(
h).

Livestock
commodity
tolerances:
An
acceptable
ruminant
feeding
study
is
available
to
ascertain
the
adequacy
of
the
established
tolerances
listed
in
40
CFR
§
180.418(
a)(
1)
for
the
following
livestock
commodities:
meat,
fat,
and
meat
byproducts
of
cattle,
goats,
hogs,
horses
and
sheep.
Also,
an
acceptable
poultry
feeding
study
is
available
to
determine
the
need
for
tolerances
in/
on
poultry
commodities.
20
Tolerances
That
Need
To
Be
Proposed
Under
40
CFR
§
180.418(
a)(
1):

Table
I
of
OPPTS
Series
860.1000
(
issued
8/
96)
now
recognizes
cotton
gin
byproducts
as
a
raw
agricultural
commodity
of
cotton.
Therefore,
field
residue
data
should
be
submitted
for
cotton
gin
byproducts
and
a
tolerance
should
be
proposed
for
this
commodity
when
adequate
field
residue
data
have
been
submitted
and
evaluated.
Based
on
the
poultry
feeding
study
and
dietary
burden
and
Codex
considerations,
HED
recommends
that
a
tolerance
level
of
0.05
ppm
be
established
for
cypermethrin
residues
in/
on
egg;
poultry,
fat;
and
poultry,
meat.

Tolerances
That
Need
To
Be
Changed
Under
40
CFR
§
180.418(
a)(
2):

As
discussed
previously,
tolerance
levels
for
livestock
commodities
should
be
the
same
for
cypermethrin
and
zeta­
cypermethrin.
Comparison
of
the
dietary
burden
calculated
for
swine
shows
that
it
is
approximately
10x
lower
than
that
for
cattle.
Accordingly,
lower
tolerance
levels
are
appropriate
for
hog
commodities.
Thus,
the
present
data
supports
the
following
changes
to
hog
tolerances:
1)
reduce
the
current
tolerance
level
of
1.0
ppm
for
hog,
fat
to
0.10
ppm,
2)
reduce
the
current
tolerance
level
of
0.2
ppm
for
hog,
meat
to
0.05
ppm,
and
3)
remove
the
current
tolerance
level
of
0.05
ppm
for
hog,
meat
byproducts.
In
addition,
the
current
tolerance
level
of
10.00
ppm
for
lettuce,
head
may
be
removed
since
this
RAC
is
already
included
in
the
crop
group
4
listing.
Finally,
the
poultry,
meat
byproducts
tolerance
level
of
0.05
ppm
should
be
removed
as
the
present
analysis
shows
expected
residues
to
be
so
low
that
a
tolerance
is
not
necessary
[
40
CFR
§
180.6(
a)(
3)].

A
summary
of
cypermethrin
tolerance
reassessments
is
presented
in
Table
C.

Table
C.
Tolerance
Reassessment
Summary
for
Cypermethrin.

Commodity
Current
Tolerance
(
ppm)
Tolerance
Reassessment
(
ppm)
Comment/
Correct
Commodity
Definition
Tolerances
listed
under
40
CFR
180.418(
a)(
1):

Brassica,
head
and
stem
2.0
2.0
[
Brassica,
head
and
stem,
subgroup]

Brassica,
leafy
14.0
14.0
[
Brassica,
leafy
greens,
subgroup]

Cattle,
fat
0.05
1.0
Cattle,
meat
0.05
0.20
Harmonizes
with
Codex
MRL
Cattle,
mbyp
0.05
0.05
[
Cattle,
meat
byproducts]

Cottonseed
0.5
0.50
[
Cotton,
undelinted
seed]

Goats,
fat
0.05
1.0
[
Goat,
fat]

Goats,
meat
0.05
0.20
[
Goat,
meat]

Goats,
mbyp
0.05
0.05
[
Goat,
meat
byproducts]

Hogs,
fat
0.05
0.10
[
Hog,
fat]

Hogs,
meat
0.05
0.05
[
Hog,
meat]
Commodity
Current
Tolerance
(
ppm)
Tolerance
Reassessment
(
ppm)
Comment/
Correct
Commodity
Definition
21
Hogs,
mbyp
0.05
 
Residue
data
support
removal
of
tolerance.

Horses,
fat
0.05
1.0
[
Horse,
fat]

Horses,
meat
0.05
0.20
[
Horse,
meat]

Horses,
mbyp
0.05
0.05
[
Horse,
meat
byproducts]

Lettuce,
head
10.0
4.0
Residue
data
support
reduction
of
tolerance.

Milk
0.05
2.5
[
Milk,
fat
(
reflecting
0.10
in
whole
milk)]

Onions,
bulb
0.1
0.10
[
Onion,
bulb]

Onions,
green
6.0
6.0
Residue
data
support
a
tolerance
level
of
3.0
ppm
for
zeta­
cypermethrin
/
[
Onion,
green]

Pecans
0.05
0.05
Sheep,
fat
0.05
1.0
Sheep,
meat
0.05
0.20
Harmonizes
with
Codex
MRL
Sheep,
mbyp
0.05
0.05
[
Sheep,
meat
byproducts]

Tolerances
That
Need
To
Be
Proposed
under
40
CFR
180.418(
a)(
1):

Cotton
gin
byproducts
­­
TBD
a
Data
remain
outstanding.

Egg
 
0.05
Poultry,
fat
 
0.05
Poultry,
meat
 
0.05
Harmonizes
with
Codex
MRL
Tolerances
That
Need
To
Be
Changed
under
40
CFR
180.418(
a)(
2):

Hog,
fat
1.0
0.10
Updated
dietary
burden
supports
lower
tolerance
level.

Hog,
meat
0.2
0.05
Updated
dietary
burden
supports
lower
tolerance
level.

Hog,
meat
byproducts
0.05
None
Updated
dietary
burden
removes
need
for
tolerance
level.

Lettuce,
head
10.00
None
Covered
by
Vegetable,
leafy,
except
Brassica,
group
04
Poultry,
meat
byproducts
0.05
None
Updated
dietary
burden
removes
need
for
tolerance
level.

a
TBD
=
To
be
determined.
22
CODEX
HARMONIZATION
The
Codex
Alimentarius
Commission
has
established
several
maximum
residue
limits
(
MRLs)
for
cypermethrin
residues
in/
on
various
plant
and
livestock
commodities.
The
Codex
and
U.
S.
tolerances
are
in
harmony
with
respect
to
MRL/
tolerance
expression.
Both
regulate
the
parent
compound,
cypermethrin.
A
comparison
of
the
Codex
MRLs
and
the
corresponding
reassessed
U.
S.
tolerances
is
presented
in
Table
D.

Special
efforts
to
increase
harmony
between
recommended
US
tolerance
levels
and
Codex
MRLs
were
made
for
the
following
commodities:
1)
poultry,
meat
(
0.05
ppm
instead
of
no
tolerance),
and
2)
meat
of
cattle,
goat,
sheep,
and
horse
(
0.20
instead
of
0.10
ppm).
The
following
conclusions
can
be
made
regarding
efforts
to
harmonize
the
U.
S.
tolerances
with
the
Codex
MRLs
with
respect
to
MRL/
tolerance
level:
(
i)
compatibility
between
the
U.
S.
tolerances
and
Codex
MRLs
exists
for
bulb
onions;
meat
byproducts;
poultry,
meat;
and
meat
of
cattle,
goat,
sheep,
and
horse;
and
(
ii)
incompatibility
of
the
U.
S.
tolerances
and
Codex
MRLs
remains
for
Brassica
vegetables,
cottonseed,
lettuce,
milk,
and
hog
commodities,
because
of
differences
in
good
agricultural
practices
and
determination
of
secondary
residue
levels
in
livestock
commodities.
No
questions
of
compatibility
exist
with
respect
to
commodities
where
Codex
MRLs
have
been
established
but
U.
S.
tolerances
do
not
exist.

Table
D.
Codex
MRLs
and
applicable
U.
S.
tolerances
for
cypermethrin.
Recommendations
for
compatibility
are
based
on
conclusions
following
reassessment
of
U.
S.
tolerances
(
see
Table
C).

Codex
U.
S.
Tolerance
(
ppm)
Recommendation
And
Comments
Commodity
(
As
Defined)
MRL
(
mg/
kg)
1
Alfalfa
forage
(
green)
5
­­
No
registered
U.
S.
uses.

Barley
0.5
­­
No
registered
U.
S.
uses.

Beans,
shelled
0.05
(*)
­­
No
registered
U.
S.
uses.

Berries
and
other
small
fruits
0.5
­­
No
registered
U.
S.
uses.

Brassica
vegetables
1
2.0
14.0
Head
and
stem
Brassica
(
subgroup
5A)
Leafy
Brassica
greens
(
subgroup
5B)
Compatibility
does
not
exist.

Cherries
1
­­
No
registered
U.
S.
uses.

Citrus
fruits
2
­­
No
registered
U.
S.
uses.

Coffee
beans
0.05
(*)
­­
No
registered
U.
S.
uses.

Common
bean
(
pods
and/
or
immature
seeds)
0.5
­­
No
registered
U.
S.
uses.

Cucumber
0.2
­­
No
registered
U.
S.
uses.

Edible
offal
(
mammalian)
0.05
(*)
0.05
Compatibility
exists.

Eggplant
0.2
­­
No
registered
U.
S.
uses.

Eggs
0.05
(*)
0.05
Compatibility
exists.

Kale
1
­­
No
registered
U.
S.
uses.

Leek
0.5
­­
No
registered
U.
S.
uses.
Table
D.
Continued.

Codex
U.
S.
Tolerance
(
ppm)
Recommendation
And
Comments
Commodity
(
As
Defined)
MRL
(
mg/
kg)
1
23
Lettuce,
head
2
10
Compatibility
does
not
exist.

Maize
0.05
(*)
­­
No
registered
U.
S.
uses.
Maize
fodder
5
­­

Meat
0.2
0.20
Compatibility
exists.

Milk
0.05
0.10
Compatibility
does
not
exist.

Mushrooms
0.05
(*)
­­
No
registered
U.
S.
uses.

Nectarine
2
­­
No
registered
U.
S.
uses.

Oilseed,
except
peanut
0.2
0.5
(
cottonseed)
Cotton
is
currently
the
only
oil
crop
with
U.
S.­
registered
cypermethrin
uses;
compatibility
does
not
exist.

Onion,
bulb
0.1
0.1
Compatibility
exists.

Peach
2
­­
No
registered
U.
S.
uses.

Peanut
0.05
(*)
­­
No
registered
U.
S.
uses.

Peas
0.05
(*)
­­
No
registered
U.
S.
uses.

Peppers
0.5
­­
No
registered
U.
S.
uses.

Plums
(
including
prunes)
1
­­
No
registered
U.
S.
uses.

Pome
fruits
2
­­
No
registered
U.
S.
uses.

Poultry
meat
0.05
(*)
0.05
Compatibility
exists.

Root
and
tuber
vegetables
0.05
(*)
­­
No
registered
U.
S.
uses.

Sorghum
straw
and
fodder,
dry
5
­­
No
registered
U.
S.
uses.

Soya
bean
(
dry)
0.05
(*)
­­
No
registered
U.
S.
uses.

Spinach
2
­­
No
registered
U.
S.
uses.

Sweet
corn
(
corn­
on­
the­
cob)
0.05
(*)
­­
No
registered
U.
S.
uses.

Tea,
green,
black
20
­­
No
registered
U.
S.
uses.

Tomato
0.5
­­
No
registered
U.
S.
uses.

Vegetable
oils,
edible
0.5
­­
No
registered
U.
S.
uses.

Wheat
0.2
­­
No
registered
U.
S.
uses.
Wheat
straw
and
fodder,
dry
5
­­

1.
All
cypermethrin
MRLs
are
final
(
CXL)
unless
otherwise
specified.
An
asterisk
(*)
signifies
that
the
MRL
was
established
at
or
about
the
limit
of
detection.
24
AGENCY
MEMORANDA
RELEVANT
TO
REREGISTRATION
CB
No(
s).:
5435,
5436,
and
5437
DP
Barcode:
None
Subject:
Cypermethrin
on
Cotton,
Lettuce,
and
Pecans.
EPA
Reg.
No.
10182­
65,
10182­
80,
and
10182­
64.
Review
of
Amended
Registration
Requests
to
Lower
Total
Amount
of
Applied
Active
Ingredient.
From:
F.
Griffith
To:
G.
LaRocca
Dated:
7/
18/
89
MRID(
s):
No
MRID
Number
CB
No(
s).:
6936
DP
Barcode:
None
Subject:
PP#
9H5571.
Cypermethrin
(
Demon)
for
Use
in
Food
Handling
Establishments.
Amendment
Dated
8/
1/
90.
From:
B.
Schneider
To:
G.
LaRocca/
A.
Heyward
Dated:
11/
16/
90
MRID(
s):
No
MRID
Number
CBRS
No(
s).:
8458,
8459,
and
8460
DP
Barcode:
D167568,
D167576,
and
D167579
Subject:
I.
D.
Nos.
279­
GREA,
279­
GREL,
and
279­
GREU.
Registration
Application
for
Use
of
S­
cypermethrin
on
Cotton,
Lettuce,
and
Pecans.
Chemical
No.
129064.
From:
B.
Cropp­
Kohlligian
To:
G.
LaRocca
Dated:
3/
20/
92
MRID(
s):
None
CBTS
No(
s).:
8092
DP
Barcode:
D165012
Subject:
PP#
1F3994
Cypermethrin
for
Use
in/
on
Sunflowers.
Evaluation
of
Analytical
Method
and
Residue
Data.
From:
G.
Herndon
To:
G.
LaRocca/
A.
Heyward
Dated:
9/
18/
91
MRID(
s):
41892600­
41892605
25
CBRS
No(
s).:
9592
DP
Barcode:
D175749
Subject:
ID#:
109702­
000279.
Cypermethrin:
FMC
Response
to
Phase
IV
Storage
Stability
Review
of
Lettuce
and
Tomatoes.
From:
W.
Anthony
To:
V.
Eagle
Dated:
5/
20/
92
MRID(
s):
42177001
CBTS
No(
s).:
6984
DP
Barcode:
D155247
Subject:
PP#
0F3863:
EPA
Reg.
Nos.
279­
3027
and
279­
3084.
Cypermethrin
(
Ammo)
on
Peanuts.
Evaluation
of
Analytical
Methods
and
Residue
Data.
From:
J.
Garbus
To:
G.
LaRocca/
T.
LeMaster
and
A.
Kocialski
Dated:
7/
28/
92
MRID(
s):
41470901­
41470906
CBRS
No.:
8295
DP
Barcode:
D166726
Subject:
ICI
Americas
Response
to
the
Phase
IV
DCI:
Poultry
Metabolism
Study;
Chemical
No.
109702.
From:
C.
Olinger
To:
V.
Dutch
Dated:
10/
5/
92
MRID(
s):
41899802
CBTS
No(
s).:
6644
and
6645
DP
Barcode:
None
Subject:
PP#
9F3815/
9H5590,
Cypermethrin
(
Ammo
2.5
EC
&
Ammo
WSB,
EPA
Reg.
Nos.
279­
3027,
279­
3084)
in/
on
Sugar
Beets.
Evaluation
of
Residue
Data
and
Analytical
Methodology.
From:
J.
Garbus
To:
G.
LaRocca
Dated:
10/
22/
92
MRID(
s):
41274701,
41274702,
and
41390200­
41390202
CBTS
No(
s).:
11115
and
11116
DP
Barcode:
D186245
Subject:
PP#
7F3498
and
PP#
4F3011
­
Cypermethrin
on
Bulb
Onions
and
Cabbage
­
Updated
Evaluation
of
Previous
CBTS
Recommendations.
From:
G.
Otakie
To:
G.
LaRocca/
T.
LeMaster
26
Dated:
3/
29/
93
MRID(
s):
None
CBTS
No(
s).:
9478
and
9479
DP
Barcode:
D174790
and
D174837
Subject:
PP#
2F4079/
2H5627:
Cypermethrin
(
Ammo
2.5,
Ammo
Oil,
and
Ammo
WSB,
EPA
Reg.
Nos.
279­
3027,
279­
3044,
and
279­
3084)
in/
on
Grain
Sorghum
and
Grain
Sorghum
RACs.
Evaluation
of
Residue
Data
and
Analytical
Methodology.
From:
J.
Garbus
To:
T.
LeMaster/
G.
LaRocca
Dated:
4/
6/
93
MRID(
s):
42169901­
42169903
and
42201701­
42201704
CBTS
No(
s).:
9503
and
9504
DP
Barcode:
D175233
and
D175238
Subject:
PP#
2F4103/
2H5631:
Cypermethrin
(
Ammo
2.5
EC
and
Ammo
WSB,
EPA
Reg.
Nos.
279­
3027
and
279­
3084)
in/
on
Tomatoes
and
Tomato
Processed
Commodities.
Evaluation
of
Residue
Data
and
Analytical
Methodology.
From:
J.
Garbus
To:
A.
Heyward/
G.
LaRocca
Dated:
9/
14/
93
MRID(
s):
42222801­
42222804
CBTS
No.:
13023
DP
Barcode:
D197868
Subject:
PP#
4F04291.
Cypermethrin
in
or
on
Brassica
Leafy
Vegetable
Group.
Evaluation
of
Residue
Data
and
Analytical
Methods.
From:
G.
Kramer
To:
G.
LaRocca
Dated:
8/
18/
94
MRID(
s):
43009701
and
43009702
CBRS
No.:
14107
DP
Barcode:
D205958
Subject:
Cypermethrin.
Case
No.
2130.
Chemical
I.
D.
No.
109702.
Addendum
to
Cotton
Processing
Study.
From:
F.
Fort
To:
V.
Dutch/
B.
Briscoe
Dated:
10/
17/
94
MRID(
s):
43270201
27
CBRS
No.:
None
DP
Barcode:
None
Subject:
Cypermethrin.
Issues
to
be
presented
to
the
HED
Metabolism
Committee
on
5/
25/
95.
From:
J.
Morales
To:
Metabolism
Committee
Dated:
5/
23/
95
MRID:
42410001,
42876301,
43421301,
42876302,
43278001,
and
43278002
CBTS
No.:
15112
DP
Barcode:
D212111
Subject:
ID#
000279­
03027.
Cypermethrin.
Label
Amendment
For
In­
Furrow
Use
On
Cotton.
From:
J.
Stokes
To:
G.
LaRocca/
A.
Heyward
Dated:
6/
20/
95
MRID:
43172001
CBRS
No.:
16183
DP
Barcode:
D219212
Subject:
The
Metabolism
Committee
Meeting
Held
on
5/
25/
95.
Cypermethrin
Metabolism
in
Plants
and
Animals
From:
J.
Morales
To:
Metabolism
Committee
Dated:
9/
15/
95
MRID:
None
CBTS
No.:
15012
DP
Barcode:
D211325
Subject:
PP#
5E4463.
Cypermethrin
In/
On
Green
Onions.
Evaluation
of
Analytical
Methodology
and
Residue
Data.
From:
J.
Stokes
To:
Hoyt
Jamerson
Dated:
02/
29/
96
MRID:
43516001
28
CBTS
No.:
15355
DP
Barcode:
D213692
Subject:
PP#
4F4291.
Cypermethrin
In/
On
the
Brassica
Leafy
Vegetable
Group.
Amendment
Dated
March
3,
1995
From:
J.
Stokes
To:
George
LaRocca/
Adam
Heyward
Dated:
03/
05/
96
MRID:
43578200
through
43578206
CBTS
No.:
16719
DP
Barcode:
D221661
Subject:
PP#
4F3012.
Cypermethrin
In/
On
the
Sweet
Corn
(
K+
CWHR)
and
Forage/
Fodder.
Amendment
Dated
November
3,
1995.
From:
J.
Stokes
To:
D.
McCall
Dated:
03/
12/
96
MRID:
43841300,
43841301,
and
43841302.

CBTS
No.:
14280
and
16816
DP
Barcode:
D206793
and
D222640
Subject:
PP#
4F4399
Cypermethrin
In/
On
Alfalfa.
Evaluation
of
Analytical
Methodology
and
Residue
Data;
Zeta­
Cypermethrin
In/
On
Alfalfa.
Evaluation
of
Analytical
Methodology
and
Residue
Data
From:
J.
Stokes
To:
D.
McCall
Dated:
05/
08/
96
MRID:
43328401
through
43328403;
43899401
and
43899402
CBTS
No.:
16534
DP
Barcode:
D220937
Subject:
PP#
7E03487
­
Cypermethrin
in/
on
Clover
(
Seed
Production)
­
Evaluation
of
Amendments.
From:
G.
Otakie
To:
D.
McCall
Dated:
5/
9/
96
MRID:
None
CBTS
No.:
16178
DP
Barcode:
D219045
Subject:
PP#
2F4079/
2H5627:
Cypermethrin
in/
on
Grain
Sorghum.
Amendment
dated
August
25,
1995.
From:
J.
Stokes
To:
D.
McCall
29
Dated:
08/
07/
96
MRID:
437751­
01
through
­
10
CBTS
No.:
17538
DP
Barcode:
D229378
Subject:
Beta­
cypermethrin
Pre­
Registration
Meeting
of
April
23,
1996,
Minutes
of
Meeting.
ID#
288063
From:
E.
Haeberer
To:
D.
McCall
Dated:
09/
12/
96
MRID:
None
CBTS
No.:
17515
DP
Barcode:
D229390
Subject:
Reregistration
of
Cypermethrin:
Meat,
Milk,
Poultry,
and
Eggs.
From:
C.
Olinger
To:
M.
Clock/
P.
Deschamp
Dated:
09/
12/
96
MRID:
None
30
MASTER
RECORD
IDENTIFICATION
NUMBERS
References
(
used
to
support
established
tolerances):

00067376
Ussary,
J.
P.;
Daniel,
J.
T.;
Harkins,
J.
T.;
et
al.
(
1980)
Cypermethrin
Residues
on
Cottonseed:
Report
Series
TMU0507/
B.
(
Unpublished
study
received
Dec
29,
1980
under
10182­
EX­
19;
prepared
in
cooperation
with
Analytical
Biochemistry
Laboratories,
Inc.,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
Del.;
CDL:
099856­
F)

00067377
Ussary,
J.
P.;
Watkins,
S.
D.;
Pearson,
F.
J.
(
1980)
Cypermethrin
Residues
in
Cottonseed
Processed
Fractions:
Report
No.
TMU0518/
B.
Rev.
Includes
undated
method
entitled:
Gas
liquid
chromatographic
method
for
the
determination
of
cypermethrin
in
oily
crops
and
their
process
fractions
(
provisional
method).
(
Unpublished
study
received
Dec
29,
1980
under
10182­
EX­
19;
prepared
in
cooperation
with
Texas
A
&
M
Univ.,
Oil
Seed
Products
Laboratory,
Food
Protein
Research
and
Development
Center,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
Del.;
CDL:
099856­
G)

00081571
Sapiets,
A.;
Swaine,
H.
(
1981)
The
Determination
of
Residues
of
Cypermethrin
in
Products
of
Animal
Origin,
a
GLC
Method
Using
Internal
Standardization.
Residue
analytical
method
no.
56
dated
Jun
17,
1981.
(
Unpublished
study
received
Sep
10,
1981
under
10182­
EX­
19;
prepared
by
Imperial
Chemical
Industries
Ltd.,
England,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
Del.;
CDL:
070288­
E)

00081574
Ussary,
J.
P.;
Fitzpatrick,
R.
D.;
Johnson,
G.
A.;
et
al.
(
1981)
Freezer
Storage
Stability
of
Cypermethrin
Residues
on
Cottonseed:
Report
Series
TMU0661/
B.
(
Unpublished
study
received
Sep
10,
1981
under
10182­
EX­
19;
submitted
by
ICI
Americas,
Inc.,
Wilmington,
Del.;
CDL:
070288­
H)

00081575
Ussary,
J.
P.;
Albritton,
J.;
Feese,
H.
D.;
et
al.
(
1981)
Cypermethrin
Residues
on
Cottonseed:
Report
Series
TMU0662/
B.
(
Unpublished
study
received
Sep
10,
1981
under
10182­
EX­
19;
submitted
by
ICI
Americas,
Inc.,
Wilmington,
Del.;
CDL:
070288­
I)

00089014
Hutson,
D.
H.;
Croucher,
A.;
Stoyden,
G.;
et
al.
(
1980)
The
Metabolic
Fate
of
Cypermethrin
in
the
Cow:
Elimination
and
Residues
Derived
from
14C­
Benzyl
Label:
TLGR.
80.121.
(
Unpublished
study
received
Dec
30,
1981
under
10182­
64;
prepared
by
Shell
Research,
Ltd.,
England,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
Del.;
CDL:
070565­
P)

00090027
Stearns,
J.
W.;
Hidalgo­
Gato,
E.;
Fung,
R.;
et
al.
(
1981)
Determination
of
Cypermethrin
Residues
in
Ginned
Cottonseed:
RAN­
0025.
Method
dated
Apr
22,
1981.
(
Unpublished
study
received
Dec
17,
1981
under
279­
EX­
88;
submitted
by
FMC
Corp.,
Philadelphia,
Pa.;
CDL:
070541­
G)
31
00090028
Stearns,
J.
W.;
Fung,
R.;
Markle,
J.
C.;
et
al.
(
1981)
Determination
of
Cypermethrin
Residues
in
Cottonseed
Processing
Products:
RAN­
0027.
Method
dated
May
14,
1981.
(
Unpublished
study
received
Dec
17,
1981
under
279­
EX­
88;
submitted
by
FMC
Corp.,
Philadelphia,
Pa.;
CDL:
070541­
H)

00090046
Ussary,
J.
P.;
Fitzpatrick,
R.
D.;
Albritton,
J.;
et
al.
(
1981)
Cypermethrin
Residues
on
Cottonseed:
Report
Series
TMU0662/
B.
(
Unpublished
study
received
Dec
30,
1981
under
10182­
64;
submitted
by
ICI
Americas,
Inc.,
Wilmington,
Del.;
CDL:
070566­
D)

00090050
Ussary,
J.
P.;
Pearson,
F.
J.;
Fitzpatrick,
R.
D.;
et
al.
(
1981)
Cypermethrin
Residues
in
Cottonseed
Process
Fractions:
Report
Series
TMU0667/
B.
(
Unpublished
study
received
Dec
30,
1981
under
10182­
64;
submitted
by
ICI
Americas,
Inc.,
Wilmington,
Del.;
CDL:
070566­
J)

00090064
Woods,
T.
M.;
Bewick,
D.
W.;
Leahey,
J.
P.
(
1980)
Cypermethrin:
Rotational
Crop
Study:
Report
Series
RJ
0161B;
4D
5/
2.
(
Unpublished
study
received
Dec
30,
1981
under
10182­
64;
prepared
by
Imperial
Chemical
Industries,
Ltd.,
England,
submitted
by
ICI
Americas,
Inc.,
Wilmington,
Del.;
CDL:
070560­
Q)

00098000
Ussary,
J.
P.;
Barnes,
J.
W.;
Harkins,
J.
T.;
et
al.
(
1981)
Cypermethrin
Field
Crop
Rotation
Study:
TMU0738/
B.
(
Unpublished
study
received
Mar
30,
1982
under
10182­
65;
submitted
by
ICI
Americas,
Inc.,
Wilmington,
Del.;
CDL:
247111­
A)

00125658
FMC
Corp.
(
1982)
Results
of
Tests
for
the
Amount
of
Residue
Remaining
and
a
Description
of
the
Analytical
Methods
(
Ammo
­
Lettuce).
(
Compilation;
unpublished
study
received
Jan
31,
1983
under
279­
3027;
CDL:
071380­
A)

00127892
ICI
Americas,
Inc.
(
1983)
[
Residues
of
Cypermethrin
in
or
on
Cottonseed,
in
the
Meat,
Fat
and
Meat
Products
of
Cattle,
Goats,
Hogs,
Horses
and
Sheep,
in
Milk
and
in
Cottonseed
Oil].
(
Compilation;
unpublished
study
received
Apr
21,
1983
under
2F2623;
CDL:
071569­
A)

00131670
ICI
Americas,
Inc.
(
1983)
Cymbush
3E
Insecticides
(
Containing
Cypermethrin):
Petition
for
Tolerance
for
Cypermethrin
on
Pecans.
(
Unpublished
study
received
Oct
19,
1983
under
10182­
65;
CDL:
251524­
A)

00132000
Ussary,
J.;
Fitzpatrick,
R.;
Wilkerson,
T.;
et
al.
(
1983)
Cymbush:
Cypermethrin
Residues
from
Aerial
Applications
to
Cottonseed:
Report
No.
TMU1185/
B.
(
Unpublished
study
received
Oct
6,
1983
under
10182­
80;
submitted
by
ICI
Americas,
Inc.,
Wilmington,
DE;
CDL:
251451­
A)

00132828
ICI
Americas,
Inc.
(
1983)
[
Residues:
Cymbush
Insecticide].
(
Compilation;
unpublished
study
received
Dec
7,
1983
under
2F2623;
CDL:
072193­
A)

00145249
Stearns,
J.
(
1984)
Determination
of
Cyperamide
and
m­
Phenoxybenzaldehyde
Residues
in/
on
Lettuce
Treated
with
Ammo
Insecticide:
RAN­
0124.
Unpublished
study
prepared
by
FMC
Corp.
23
p.
32
40880202
Fitzpatrick,
R.
(
1981)
A
Gas­
Liquid
Chromatographic
Method
for
the
Determination
of
Cypermethrin
(
PP383)
Residue
Chemistry
Data.
Determination
of
Cypermethrin
(
PP383)
in
Crops,
Soils
and
Water:
Laboratory
Project
ID
GRAM
7/
1.
Unpublished
study
prepared
by
ICI
Americas
Inc.
18
p.

41899802
Huston,
D.
;
Stoydin,
G.
(
1982)
Cypermethrin:
Residues
in
Eggs
and
Tissues
of
Domestic
Fowl
Following
Repeated
Oral
Dosing
with
[
Carbon
14]­
Cypermethrin:
Lab
Project
Number:
XXB.
2152.
Unpublished
study
prepared
by
Shell
Research
Ltd.
33
p
42177001
Markle,
J.
(
1985)
Cold
Storage
Stability
of
Cypermethrin
Residues
in/
on
Various
Crops
and
Soils:
Lab
Project
Number:
S191­
83­
02.
Unpublished
study
prepared
by
FMC
Corp.
22
p.

42410001
Hawkins,
D.;
Kirkpatrick,
D.;
Shaw,
D.
(
1992)
The
Metabolism
of
[
carbon
14]­
Permethrin
in
the
Goat:
Lab
Project
Number:
HRC/
ISN
248/
920216.
Unpublished
study
prepared
by
Huntingdon
Research
Centre,
Ltd.
97
p.

42876301
ElNaggar,
S.
(
1993)
Nature
of
the
Residue
in
Plants:
Cotton
Metabolism
of
(
Carbon
14)­
Cypermethrin:
Lab
Project
Number:
P­
2748:
ML­
91­
712:
191COT91M1.
Unpublished
study
prepared
by
Pan­
Agricultural
Labs.,
and
FMC
Corp.
273
p.

42876302
ElNaggar,
S.
(
1993)
Nature
of
the
Residue
in
Livestock:
Metabolism
of
(
Carbon
14)­
Cypermethrin
in
Laying
Hens:
Lab
Project
Number:
P­
2851:
SC910198:
191POU91M1.
Unpublished
study
prepared
by
Battelle
Labs.,
and
FMC
Corp.
275
p.

43009701
Kim,
I­
Y.
(
1993)
Magnitude
of
the
Residues
of
Cypermethrin,
Dichlorovinyl
Acid,
m­
Phenoxybenzoic
Acid,
and
Cyperamide
in/
on
Broccoli:
Lab
Project
Number:
P­
2762:
191BRO90R1.
Unpublished
study
prepared
by
FMC
Corp.
124
p.

43009702
Starner,
K.
(
1993)
Magnitude
of
the
Residues
of
Cypermethrin,
Dichlorovinyl
Acid
and
m­
Phenoxybenzoic
Acid
in/
on
Mustard
Greens
Treated
with
Ammo
2.5
EC
Insecticide:
Lab
Project
Number:
RAN­
0241:
191MUS90R1.
Unpublished
study
prepared
by
FMC
Corp.
106
p.

43172001
Castro,
T.
(
1994)
Magnitude
of
the
Residues
of
Cypermethrin,
Dichlorovinyl
Acid
and
Meta­
Phenoxybenzoic
Acid
in/
on
Cotton
Seeds
Treated
with
One
In­
Furrow
Application
of
Ammo
2.5
EC
Insecticide
Followed
by
Five
Foliar
Applications
of
Ammo
2.5EC:
Lab
Project
Number:
RAN­
0253:
191COT93R1.
Unpublished
study
prepared
by
FMC
Corp.
79
p.

43270201
FMC
Corp.
(
1994)
Response
to
EPA
Review
of
Phase
III
Submission
­
Clarification
of
the
Delinting
Process
in
Cotton
Processing
Studies:
Cypermethrin.
Unpublished
study.
22
p.

43278001
Nagel,
W.
(
1994)
Magnitude
of
the
Residue
of
Cypermethrin
and
its
Metabolites
in/
on
Poultry
Tissues
and
Eggs
Following
Oral
Administration
to
Laying
Hens:
Lab
Project
Number:
191POU93R1:
P­
2925:
112­
010­
09.
Unpublished
study
prepared
by
FMC
Corp.
171
p.
33
43278002
Chen,
A.
(
1994)
Magnitude
of
the
Residue
of
Cypermethrin
and
its
Acid
Metabolites
in/
on
Meat,
Meat
By­
products,
and
Milk
Following
Oral
Administration
to
Cows:
Lab
Project
Number:
191COW92R1:
P­
2901:
112­
004­
10.
Unpublished
study
prepared
by
FMC
Corp.
and
Bio­
Life
Associates,
Inc.
185
p.

43278003
Chen,
A.
(
1994)
Residue
Analytical
Method
for
the
Determination
of
Cypermethrin
and
its
Acid
Metabolites
in/
on
Cow
Milk,
Meat,
and
Meat
By­
products:
Lab
Project
Number:
191COW92R1:
P­
2901M:
Unpublished
study
prepared
by
FMC
Corp.
57
p.

43421301
George,
M.
(
1994)
Cypermethrin
(
Ammo)
Insecticide:
Nature
of
the
Residue:
Metabolism
of
Cypermethrin
in/
on
Field
Corn
Plants:
Interim
Data
Summary:
Lab
Project
Number:
191COF93M1.
Unpublished
study
prepared
by
FMC
Corporation.
20
p.

43516001
Samoil,
K.
S.
(
1995)
Magnitude
of
the
Residue:
Cypermethrin
on
Onion
(
Green):
Study
Number
03963:
Unpublished
study
submitted
by
Office
of
IR­
4,
Rutgers
University,
New
Brunswick,
NJ.
382
p.

43578201
Akbari,
Z.
(
1995)
Ammo
Insecticide
­
Cold
Storage
Stability
of
Cypermethrin
in/
on
Broccoli
and
Mustard
Greens:
Lab
Project
Number:
191CSS92R3.
Unpublished
study
prepared
by
FMC
Corporation.
42
p.

43578202
Starner,
K.
(
1993)
Ammo
Insecticide
­
Storage
Stability
of
the
Residues
of
Cypermethrin,
Dichlorovinyl
Acid,
and
m­
Phenoxybenzoic
Acid
in/
on
Lettuce:
Lab
Project
Number:
RAN­
0251:
191CSS90R2.
Unpublished
study
prepared
by
FMC
Corp.
54
p.

43578203
Hebert,
V.
R.
(
1994)
Ammo
Insecticide
­
Magnitude
of
the
Residue
of
Cypermethrin,
Dichlorovinyl
Acid,
and
m­
Phenoxybenzoic
Acid
in/
on
Lettuce:
Lab
Project
Number:
RAN­
0227:
191LET89R1.
Unpublished
study
prepared
by
FMC
Corp.
105
p.

43578204
Noon,
P.
(
1994)
Magnitude
of
the
Residues
of
zeta­
Cypermethrin
(
Proposed
Common
Name),
Dichlorovinyl
Acid,
and
meta­
Phenoxybenzoic
Acid
in/
on
Broccoli
Treated
with
Six
Applications
of
Fury
1.5
EW
Insecticide
at
0.05
Pounds
Active
Ingredient
per
Acre
per
Application
with
a
1­
Day
Pre­
Harvest
Interval:
Lab
Project
Number:
RC­
0047:
194BRO93R1.
Unpublished
study
prepared
by
FMC
Corp.
85
p.

43578205
Noon,
P.
(
1994)
Magnitude
of
the
Residues
of
zeta­
Cypermethrin
(
Proposed
Common
Name),
Dichlorovinyl
Acid,
and
meta­
Phenoxybenzoic
Acid
in/
on
Cabbage
Treated
with
Six
Applications
of
Fury
1.5
EW
Insecticide
at
0.05
Pounds
Active
Ingredient
per
Acre
per
Application
with
a
1­
Day
Pre­
Harvest
Interval:
Lab
Project
Number:
RC­
0045:
194CAB93R1.
Unpublished
study
prepared
by
FMC
Corp.
84
p.

43578206
Noon,
P.
(
1994)
Magnitude
of
the
Residues
of
zeta­
Cypermethrin
(
Proposed
Common
Name),
Dichlorovinyl
Acid,
and
meta­
Phenoxybenzoic
Acid
in/
on
Mustard
Greens
Treated
with
Four
Applications
of
Fury
1.5
EW
Insecticide
at
0.05
Pounds
Active
Ingredient
per
Acre
per
Application
34
with
a
1­
Day
Pre­
Harvest
Interval:
Lab
Project
Number:
RC­
0046:
194MUS93R1.
Unpublished
study
prepared
by
FMC
Corp.
85
p.

43775103
Nagel,
W.
(
1994)
Residue
Analytical
Method
for
the
Determination
of
Cypermethrin
and
Its
Acid
Metabolites
in/
on
Poultry
Egg
Matrices:
Lab
Project
Number:
191POU93R1:
P2925M.
Unpublished
study
prepared
by
FMC
Corp.
42
p.

43775104
Nagel,
W.
(
1994)
Radiovalidation
of
Residue
Methodology
for
Cypermethrin
and
Its
Major
Metabolites
in/
on
Poultry
Breast
Muscle
and
Egg
Yolk:
Lab
Project
Number:
191POU94R1:
P2994.
Unpublished
study
prepared
by
FMC
Corp.
58
p.

43775105
Griffin,
P.;
Perez,
R.
(
1995)
Independent
Method
Validation
of
FMC
Analytical
Method
Report
P­
2901M
"
Residue
Analytical
Method
for
the
Determination
of
Cypermethrin
and
Its
Acid
Metabolites
in/
on
Cow
Milk,
Meat,
and
Meat
By­
Products
Final
Report:
Lab
Project
Number:
191MVL94R3:
ADPEN­
911­
94­
0611:
PC­
0223.
Unpublished
study
prepared
by
ADPEN
Labs,
Inc.
35
p.

43775106
Griffin,
P.
(
1995)
Independent
Method
Validation
of
FMC
Analytical
Method
Report
P­
2901M
"
Residue
Analytical
Method
for
the
Determination
of
Cypermethrin
and
Its
Acid
Metabolites
in/
on
Cow
Milk,
Meat,
and
Meat
By­
Products
Final
Report:
Lab
Project
Number:
191MVL94R1
ADPEN­
911­
94­
0504:
P­
0221.
Unpublished
study
prepared
by
ADPEN
Labs,
Inc.
41
p.

43775107
Griffin,
P.;
Perez,
R.
(
1995)
Independent
Method
Validation
of
FMC
Analytical
Method
Report
P­
2901M
"
Residue
Analytical
Method
for
the
Determination
of
Cypermethrin
and
Its
Acid
Metabolites
in/
on
Cow
Milk,
Meat,
and
Meat
By­
Products
Final
Report:
Lab
Project
Number:
191MVL94R2:
ADPEN­
911­
94­
0610:
PC­
0222.
Unpublished
study
prepared
by
ADPEN
Labs,
Inc.
32
p.

43775108
Griffin,
P.;
Perez,
R.
(
1995)
Independent
Method
Validation
of
FMC
Analytical
Method
Report
P­
2925M
"
Residue
Analytical
Method
for
the
Determination
of
Cypermethrin
and
Its
Acid
Metabolites
in/
on
Poultry
Eggs
Matrices"
Final
Report:
Lab
Project
Number:
191MVL94R4:
ADPEN­
911­
94­
0712:
PC­
0224.
Unpublished
study
prepared
by
ADPEN
Labs,
Inc.
41
p.

43775109
Barrett,
G.
(
1994)
Storage
Stability
of
Cypermethrin,
cis/
trans
Dichlorovinyl
Acids
and
m­
Phenoxybenzoic
Acid
in
Poultry
Eggs
and
Tissues:
Lab
Project
Number:
191CSS94R1:
P­
2970.
Unpublished
study
prepared
by
FMC
Corp.
60
p.

43775110
Barrett,
G.;
Pearsall,
J.
(
1994)
Storage
Stability
of
Cypermethrin,
cis/
trans
Dichlorovinyl
Acids
and
m­
Phenoxybenzoic
Acid
in
Cow
Milk
and
Tissues:
Lab
Project
Number:
191CSS93R1:
P­
2986.
Unpublished
study
prepared
by
FMC
Corp.
80
p.

43841301
Leppert,
B.
C.
(
1993)
Magnitude
of
the
Residues
of
Cypermethrin,
Dichlorovinyl
Acid,
and
meta­
Phenoxybenzoic
Acid
in/
on
Sweet
Corn
Treated
with
Six
Applications
of
Ammo
2.5
EC
35
Insecticide
at
0.1
Lb
Active
Ingredient
per
Acre
per
Application:
Lab
Project
Number:
RAN­
0243:
191COS90R1.
Unpublished
study
prepared
by
FMC
Corp.
98
p.

43841302
Munoz,
W.
A.
(
1993)
Methodology
for
the
Determination
of
the
Magnitude
of
the
Residues
of
Cypermethrin,
Dichlorovinyl
Acid,
and
meta­
Phenoxybenzoic
Acid
in/
on
Sweet
Corn:
Lab
Project
Number:
RAN­
0242M:
191COS90R1
&
191COS92R1.
Unpublished
study
prepared
by
FMC
Corp.
76
p.