Document ID: EPA-HQ-OPP-2006-0167-0005
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2006-08-28T04:00Z

Quinoxyfen
Dietary
Exposure
and
Risk
Assessment
DP
Number:
328363
PC
Code:
055459
______________________________________________________________________________________

Page
1
of
15
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
MEMORANDUM
DATE:
20­
APR­
2006
SUBJECT:
Quinoxyfen:
Chronic
Aggregate
Dietary
(
Food
and
Drinking
Water)
Exposure
and
Risk
Assessment
for
the
Proposed
Section
3
Registration
on
Peppers
(
PP#
3E6755);
Melon
Subgroup
9A
(
PP#
5E6969);
Strawberry
(
PP#
5E6970);
and
Lettuce
(
Head
and
Leaf)
(
PP#
5E6970).

PC
Code:
055459
Decision
Number:
354885
DP
Number:
328363
REVIEWER:
Susan
L.
Stanton,
Environmental
Scientist
Reregistration
Branch
3
Health
Effects
Division
(
7509C)

THROUGH:
Thomas
Bloem,
Chemist
David
Soderberg,
Chemist
Dietary
Exposure
Science
Advisory
Council
(
DESAC)
Health
Effects
Division
(
7509C)

and
P.
V.
Shah,
Branch
Senior
Scientist
Registration
Action
Branch
1
Health
Effects
Division
(
7509C)

TO:
George
F.
Kramer,
Ph.
D.,
Chemist
Registration
Action
Branch
1
Health
Effects
Division
(
7509C)

and
Dan
Rosenblatt,
Chief
Minor
Use,
Inerts
&
Emergency
Response
Branch
Registration
Division
(
7505C)
Quinoxyfen
Dietary
Exposure
and
Risk
Assessment
DP
Number:
328363
PC
Code:
055459
______________________________________________________________________________________

Page
2
of
15
Executive
Summary
A
chronic
dietary
risk
assessment
was
conducted
using
the
Dietary
Exposure
Evaluation
Model
(
DEEM­
FCID
 
)
,
Version
2.03,
which
uses
food
consumption
data
from
the
U.
S.
Department
of
Agriculture's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII)
from
1994­
1996
and
1998.
The
analysis
was
performed
to
support
FIFRA
§
3
registration
requests
for
the
fungicide,
quinoxyfen,
on
peppers
(
bell
and
non­
bell),
lettuce
(
head
and
leaf),
strawberry
and
melons.

No
toxic
effects
attributable
to
a
single
(
i.
e.,
acute)
exposure
to
quinoxyfen
have
been
identified;
therefore,
an
acute
Reference
Dose
(
aRfD)
has
not
been
established
for
quinoxyfen
and
an
acute
dietary
exposure
assessment
has
not
been
conducted.
Also,
since
there
is
no
evidence
that
quinoxyfen
is
carcinogenic
to
humans,
a
dietary
cancer
assessment
is
not
required.

Chronic
Dietary
Exposure
Results
and
Characterization
The
tier
1
chronic
assessment
assumed
that
quinoxyfen
residues
are
present
in
all
commodities
at
tolerance
levels
and
that
100%
of
all
crops
are
treated.
DEEM
 
Version
7.81
default
processing
factors
were
used
to
estimate
residues
in
cherry
juice,
grape
juice
and
raisins.
Drinking
water
was
incorporated
directly
into
the
dietary
assessment
using
the
estimated
drinking
water
concentration
(
EDWC)
for
surface
water
generated
by
the
PRZM­
EXAMS
model.

The
resulting
chronic
dietary
exposure
estimates
for
food
and
water
combined
are
well
below
HED's
level
of
concern
(
i.
e.,
<
100%
of
the
cPAD
of
0.2
mg/
kg
bw/
day)
for
the
overall
U.
S.
population
and
all
population
subgroups.
Using
the
DEEM­
FCID
software,
dietary
exposure
is
estimated
at
0.002596
mg/
kg/
day
for
the
U.
S.
population
(
1.3%
of
the
cPAD)
and
0.003923
mg/
kg/
day
(
2.0%
of
the
cPAD)
for
children
1
to
2
years
old,
the
population
subgroup
with
the
highest
estimated
chronic
dietary
exposure
to
quinoxyfen.

I.
Introduction
Dietary
risk
assessment
incorporates
both
exposure
and
toxicity
of
a
given
pesticide.
For
chronic
assessments,
the
risk
is
expressed
as
a
percentage
of
a
maximum
acceptable
dose
(
i.
e.,
the
dose
which
HED
has
concluded
will
result
in
no
unreasonable
adverse
health
effects).
This
dose
is
referred
to
as
the
population
adjusted
dose
(
PAD).
The
PAD
is
equivalent
to
the
reference
dose
(
RfD)
divided
by
the
special
Food
Quality
Protection
Act
(
FQPA)
Safety
Factor.

For
chronic
exposures,
HED
is
concerned
when
estimated
dietary
risk
exceeds
100%
of
the
cPAD.
References
which
discuss
the
chronic
risk
assessment
in
more
detail
are
available
on
the
EPA/
pesticides
web
site:
"
Available
Information
on
Assessing
Exposure
from
Pesticides,
A
User's
Guide,"
6/
21/
2000,
web
link:
http://
www.
epa.
gov/
fedrgstr/
EPA­
PEST/
2000/
July/
Day­
12/
6061.
pdf
;
or
see
SOP
99.6
(
8/
20/
99).

The
most
recent
HED
dietary
risk
assessment
for
quinoxyfen
was
conducted
by
Jennifer
Tyler
(
03/
25/
2003,
DP285313)
to
support
the
first
food
uses
of
quinoxyfen
(
cherries,
grapes
and
hops).
A
subsequent
assessment
to
support
the
FIFRA
§
18
uses
on
melons,
pumpkins
and
winter
squash
was
conducted
by
the
Registration
Division's
ARIA
team
in
August,
2004
(
D302199).
Quinoxyfen
Dietary
Exposure
and
Risk
Assessment
DP
Number:
328363
PC
Code:
055459
______________________________________________________________________________________

Page
3
of
15
II.
Food
Residue
Information
Residues
of
Concern:
Based
on
the
previously
submitted
cucumber,
grape,
sugar
beet
and
tomato
metabolism
studies,
the
nature
of
the
residue
in
plants
is
adequately
understood.
The
residue
of
concern
for
tolerance
and
risk
assessment
purposes
is
quinoxyfen,
per
se.

Tolerances:
Permanent
tolerances
have
been
established
under
40
CFR
§
180.588(
a)
for
residues
of
quinoxyfen,
5,7­
dichloro­
4­(
4­
fluorophenoxy)
quinoline,
in
or
on
cherry
(
sweet
and
tart)
at
0.3
ppm,
dried
hop
cones
at
3.0
ppm
and
grape
at
0.6
ppm.
Time­
limited
tolerances
for
residues
of
quinoxyfen
have
been
established
on
pumpkin,
winter
squash
and
melons
(
cucurbit
vegetable
subgroup
9A)
at
0.3
ppm
in
connection
with
FIFRA
§
18
emergency
exemptions.
These
timelimited
tolerances
expire
on
12/
31/
2007.

IR­
4
has
proposed
new
tolerances
for
residues
of
quinoxyfen
in
or
on
the
following
commodities:
pepper,
bell;
pepper,
non­
bell;
eggplant;
sub­
group
9A
(
melon);
lettuce,
leaf;
lettuce,
head;
and
strawberry.
HED
has
reviewed
residue
data
submitted
to
support
these
tolerances
and
concluded
that
the
following
tolerances
are
appropriate
[
George
Kramer;
April,
2006;
DP
323549,
327820,
327822].

Crop
Commodity
Recommended
Tolerance
(
ppm)

Pepper,
bell
0.35
Pepper,
non­
bell
1.7
Eggplant1
To
be
determined
Melon,
sub­
Group
9A
0.08
Lettuce,
leaf
19
Lettuce,
head
7.0
Strawberry
0.90
1Additional
data
are
required
to
support
the
tolerance/
use
on
eggplant.

Residue
Data
used
for
the
Chronic
Assessment:
The
unrefined,
tier
1
chronic
assessment
assumed
that
quinoxyfen
residues
are
present
in
all
commodities
at
established
or,
for
the
new
crops,
recommended
tolerance
levels
and
that
100%
of
all
crops
are
treated.
DEEM
 
Version
7.81
default
processing
factors
were
used
to
estimate
residues
in
cherry
juice,
grape
juice
and
raisins.

The
recommended
permanent
tolerance
for
melons
of
0.08
ppm
was
used
instead
of
the
higher,
time­
limited
tolerance
of
0.3
ppm,
since
HED
is
recommending
that
the
time­
limited
tolerance
be
revoked
concurrent
with
the
establishment
of
the
permanent
tolerance
for
melons.

The
proposed
use
of
quinoxyfen
on
eggplant
was
not
considered
in
this
assessment,
since
additional
data
are
required
and
HED
is
not
recommending
that
a
tolerance
be
established
at
this
time.
Quinoxyfen
Dietary
Exposure
and
Risk
Assessment
DP
Number:
328363
PC
Code:
055459
______________________________________________________________________________________

Page
4
of
15
III.
Drinking
Water
Data
Reference:
EFED
Drinking
Water
Assessment
for
the
IR­
4
Tolerance
Petition
for
Use
of
Quinoxyfen
on
Lettuce,
Strawberries,
Melons,
Peppers
(
Bell
and
Non­
bell),
and
Eggplants;
Cheryl
Sutton;
03/
23/
2006;
D314492.

The
residue
of
concern
in
drinking
water
is
quinoxyfen,
per
se.
The
A
EFED
Risk
Assessment
for
the
Section
3
Registration
of
Quinoxyfen
@

(
DP
Barcodes:
D278515,
D285770,
D286376)
was
completed
in
August
2003.
Uses
included
in
the
assessment
were
grapes,
hops
and
cherries.
In
that
assessment,
estimated
drinking
water
concentrations
(
EDWCs)
for
use
in
the
human
health
risk
assessment
were
determined
using
a
maximum
annual
application
rate
for
cherries
of
0.55
lb
a.
i./
A.
Because
maximum
application
rates
for
the
proposed
uses
on
lettuce,
strawberries,
melons
and
peppers
do
not
exceed
the
application
rate
for
cherries,
the
previously
generated
EDWCs
are
still
current
and
were
used
in
this
dietary
exposure
assessment.

Table
2.
EDWCs
for
the
drinking
water
assessment
based
on
quinoxyfen
use
on
cherries.

Surface
water
drinking
water
sources
acute:
13.34
ug/
L
(
ppb)
1
1­
in­
10­
years
(
chronic):
8.35
ug/
L
(
ppb)
30­
year
average:
5.95
ug/
L
(
ppb)

Groundwater
drinking
water
sources
0.00600
ug/
L
(
ppb)
or
6.00
ng/
L
(
parts
per
trillion)
1EDWC
values
were
generated
using
the
PRZM/
EXAMS
model
with
an
orchard
airblast
spray
to
cherries
in
Michigan
application
scenario
which
represents
the
highest
annual
application
rate
among
the
registered
and
proposed
new
uses.

The
highest
chronic
quinoxyfen
concentration
was
estimated
for
surface
water
using
the
PRZM/
EXAMS
model.
The
model
and
its
description
are
available
at
the
EPA
internet
site:
http://
www.
epa.
gov/
oppefed1/
models/
water/.
The
chronic
(
1
in
10
year
annual
mean)
value
of
8.35
ppb
was
incorporated
directly
as
a
point
estimate
in
the
DEEM
analysis
to
assess
exposure
to
quinoxyfen
from
drinking
water.

IV.
DEEM­
FCID
 
Program
and
Consumption
Information
A
quinoxyfen
chronic
dietary
exposure
assessment
was
conducted
using
the
Dietary
Exposure
Evaluation
Model
software
with
the
Food
Commodity
Intake
Database
(
DEEM­
FCID
 
,
Version
2.03),
which
incorporates
consumption
data
from
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII),
1994­
1996
and
1998.
The
1994­
96,
98
data
are
based
on
the
reported
consumption
of
more
than
20,000
individuals
over
two
non­
consecutive
survey
days.
Foods
"
as
consumed"
(
e.
g.,
apple
pie)
are
linked
to
EPA­
defined
food
commodities
(
e.
g.
apples,
peeled
fruit
­
cooked;
fresh
or
N/
S;
baked;
or
wheat
flour
­
cooked;
fresh
or
N/
S,
baked)
using
publicly
available
recipe
translation
files
developed
jointly
by
USDA/
ARS
and
EPA.
For
chronic
exposure
assessment,
consumption
data
are
averaged
for
the
entire
U.
S.
population
and
within
population
subgroups,
but
for
acute
exposure
assessment
are
retained
as
individual
consumption
events.
Based
on
analysis
of
the
1994­
96,
98
CSFII
consumption
data,
which
took
Quinoxyfen
Dietary
Exposure
and
Risk
Assessment
DP
Number:
328363
PC
Code:
055459
______________________________________________________________________________________

Page
5
of
15
into
account
dietary
patterns
and
survey
respondents,
HED
concluded
that
it
is
most
appropriate
to
report
risk
for
the
following
population
subgroups:
the
general
U.
S.
population,
all
infants
(<
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
adults
20­
49,
females
13­
49,
and
adults
50+
years
old.

For
chronic
dietary
exposure
assessments,
an
estimate
of
the
residue
level
in
each
food
or
foodform
(
e.
g.,
orange
or
orange
juice)
on
the
food
commodity
residue
list
is
multiplied
by
the
average
daily
consumption
estimate
for
that
food/
food
form
to
produce
a
residue
intake
estimate.
The
resulting
residue
intake
estimate
for
each
food/
food
form
is
summed
with
the
residue
intake
estimates
for
all
other
food/
food
forms
on
the
commodity
residue
list
to
arrive
at
the
total
average
estimated
exposure.
Exposure
is
expressed
in
mg/
kg
body
weight/
day
and
as
a
percent
of
the
cPAD.
This
procedure
is
performed
for
each
population
subgroup.

V.
Toxicological
Information
Quinoxyfen
was
presented
to
the
HED
Hazard
Identification
Assessment
and
Review
Committee
(
HIARC)
on
12/
10/
02
(
Memo,
D.
Nixon,
1/
28/
03;
TXR
No.
0051474).
Based
on
the
HIARC
conclusions
and
the
quinoxyfen
risk
assessment
team's
evaluation
of
the
hazard
and
exposure
data,
the
team
recommended
that
the
special
FQPA
Safety
Factor
be
reduced
to
1x.
A
summary
of
the
toxicological
doses
and
endpoints
selected
for
dietary
exposure
assessment
is
provided
below
in
Table
3.

Table
3.
Summary
of
Toxicological
Doses
and
Endpoints
for
Quinoxyfen
for
Use
in
Dietary
Exposure
Assessment
Exposure
Scenario
Dose
Used
in
Risk
Assessment,
UF
Hazard
and
Exposure
Based
Special
FQPA
Safety
Factor
Study
and
Toxicological
Effects
Acute
Dietary
All
Populations
Not
Applicable
Not
Applicable
No
endpoint
attributable
to
a
single
exposure
was
identified
for
the
general
population
or
females
of
reproductive
age.

Chronic
Dietary
all
populations
NOAEL=
20
mg/
kg/
day
UF
=
100
Chronic
RfD
=
0.2
mg/
kg/
day
FQPA
SF
=
1x
cPAD
=
cRfD
÷
FQPA
SF
=
0.2
mg/
kg/
day
Combined
chronic
toxicity/
carcinogenicity
­
rat
LOAEL
=
80
mg/
kg/
day,
based
on
increases
in
severity
of
chronic
progressive
glomerulonephropathy
in
the
males
and
minimal
decreases
in
body
weight
and
body
weight
gain
in
both
sexes.

Cancer
Not
likely
to
be
carcinogenic
to
humans,
based
on
the
lack
of
evidence
of
carcinogenicity
in
rats
and
mice.

UF
=
uncertainty
factor,
FQPA
SF
=
Special
FQPA
safety
factor,
NOAEL
=
no
observed
adverse
effect
level,
LOAEL
=
lowest
observed
adverse
effect
level
Quinoxyfen
Dietary
Exposure
and
Risk
Assessment
DP
Number:
328363
PC
Code:
055459
______________________________________________________________________________________

Page
6
of
15
VI.
Results/
Discussion
As
stated
above,
for
chronic
assessments,
HED
is
concerned
when
dietary
risk
exceeds
100%
of
the
cPAD.
The
DEEM­
FCID
 
analyses
estimate
the
dietary
exposure
of
the
U.
S.
population
and
various
population
subgroups.
The
results
reported
in
Table
4
are
for
the
general
U.
S.
Population,
all
infants
(<
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
females
13­
49,
adults
20­
49,
and
adults
50+
years.

Quinoxyfen
chronic
dietary
(
food
+
water)
exposure
estimates
using
the
DEEM­
FCID
 
software
are
well
below
HED's
level
of
concern
for
the
U.
S.
population
and
each
of
the
population
subgroups.
Dietary
exposure
was
estimated
at
0.002596
mg/
kg/
day
for
the
U.
S.
population
(
1.3%
of
the
cPAD)
and
0.003923
mg/
kg/
day
(
2.0%
of
the
cPAD)
for
the
most
highly
exposed
population
subgroup
(
children,
1­
2
years
old).
The
estimated
exposures/
risks
for
food,
drinking
water
and
combined
food
and
water
are
summarized
in
Table
4
for
all
populations.

Table
4.
Summary
of
Chronic
Dietary
Exposure
and
Risk
for
Quinoxyfen1
Food
Only
Drinking
Water
Only
Total
Population
Subgroup
Exposure
(
mg/
kg/
day)
%
cPAD
Exposure
(
mg/
kg/
day)
%
cPAD
Exposure
(
mg/
kg/
day)
%
cPAD
General
U.
S.
Population
0.002420
1.2
0.000176
0.1
0.002596
1.3
All
Infants
(<
1
year
old)
0.000784
0.4
0.000577
0.3
0.001361
0.7
Children
1­
2
years
old
0.003662
1.8
0.000261
0.1
0.003923
2.0
Children
3­
5
years
old
0.003294
1.6
0.000245
0.1
0.003539
1.8
Children
6­
12
years
old
0.002390
1.2
0.000169
0.1
0.002559
1.3
Youth
13­
19
years
old
0.002062
1.0
0.000127
0.1
0.002189
1.1
Adults
20­
49
years
old
0.002486
1.2
0.000164
0.1
0.002651
1.3
Adults
50+
years
old
0.002234
1.1
0.000173
0.1
0.002407
1.2
Females
13­
49
years
old
0.002571
1.3
0.000164
0.1
0.002734
1.4
1The
population
subgroup
with
the
highest
estimated
chronic
dietary
(
food
+
drinking
water)
exposure
and
risk
is
indicated
by
bold
text.

VII.
Characterization
of
Inputs/
Outputs
These
chronic
dietary
exposure
and
risk
estimates
are
conservative
since
they
assume
that
100%
of
crops
are
treated
with
quinoxyfen
and
that
residues
are
present
at
tolerance
levels.
In
addition,
drinking
water
exposure
estimates
were
based
on
screening
level
estimates
generated
by
the
PRZM­
EXAMS
model.
Dietary
exposure
estimates
could
be
refined
through
the
use
of
anticipated
residues
and
percent
crop
treated
data,
as
well
as
refined
estimated
drinking
water
Quinoxyfen
Dietary
Exposure
and
Risk
Assessment
DP
Number:
328363
PC
Code:
055459
______________________________________________________________________________________

Page
7
of
15
concentrations.
However,
since
estimated
exposures
and
risks
using
conservative
assumptions
are
well
below
HED's
level
of
concern,
such
refinement
is
not
warranted.

VIII.
Conclusions
This
Tier
1
chronic
dietary
exposure
analysis
using
DEEM­
FCID
 
indicates
that
chronic
dietary
exposure
to
quinoxyfen
from
food
and
drinking
water
is
well
below
HED's
level
of
concern
for
this
pesticide.
Estimated
chronic
dietary
exposures
are
less
than
or
equal
to
2%
of
the
cPAD
for
the
general
U.
S.
population
and
all
population
subgroups.

IX.
List
of
Attachments
Chronic
Food
Only
Input
File
Chronic
Food
Only
Results
File
Chronic
Drinking
Water
Only
Input
File
Chronic
Drinking
Water
Only
Results
File
Chronic
Food
+
Drinking
Water
Input
File
Chronic
Food
+
Drinking
Water
Results
File
Quinoxyfen
Dietary
Exposure
and
Risk
Assessment
DP
Number:
328363
PC
Code:
055459
______________________________________________________________________________________

Page
8
of
15
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
QUNIOXYFEN
1994­
98
data
Residue
file:
C:\
Documents
and
Settings\
sstanton\
My
Documents\
DEEM­
FCID
Files\
Quinoxyfen\
Quinoxyfen
food
only.
R98
Adjust.
#
2
NOT
used
Analysis
Date
04­
13­
2006
Residue
file
dated:
04­
13­
2006/
14:
15:
10/
8
Reference
dose
(
RfD)
=
0.2
mg/
kg
bw/
day
Comment:
Chronic
dietary
assessment
(
FOOD
ONLY)
to
support
new
uses
on
lettuce,
strawberry,
pepper
&
melons.
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Food
Crop
Residue
Adj.
Factors
Comment
EPA
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
09010750
9A
Cantaloupe
0.080000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
09010800
9A
Casaba
0.080000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
12000900
12
Cherry
0.300000
1.000
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
12000901
12
Cherry­
babyfood
0.300000
1.000
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
12000910
12
Cherry,
juice
0.300000
1.500
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
12000911
12
Cherry,
juice­
babyfood
0.300000
1.500
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
95001750
O
Grape
0.600000
1.000
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
95001760
O
Grape,
juice
0.600000
1.200
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
95001761
O
Grape,
juice­
babyfood
0.600000
1.200
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
95001770
O
Grape,
leaves
0.600000
1.000
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
95001780
O
Grape,
raisin
0.600000
4.300
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
95001790
O
Grape,
wine
and
sherry
0.600000
1.000
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
09011870
9A
Honeydew
melon
0.080000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
95001880
O
Hop
3.000000
1.000
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
04012040
4A
Lettuce,
head
7.000000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
04012050
4A
Lettuce,
leaf
19.000000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
08002700
8
Pepper,
bell
0.350000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
08002701
8
Pepper,
bell­
babyfood
0.350000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
08002710
8
Pepper,
bell,
dried
0.350000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
08002711
8
Pepper,
bell,
dried­
babyfood
0.350000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
08002720
8
Pepper,
nonbell
1.700000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
08002721
8
Pepper,
nonbell­
babyfood
1.700000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
Quinoxyfen
Dietary
Exposure
and
Risk
Assessment
DP
Number:
328363
PC
Code:
055459
______________________________________________________________________________________

Page
9
of
15
08002730
8
Pepper,
nonbell,
dried
1.700000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
09023080
9B
Pumpkin
0.300000
1.000
1.000
Sec.
1
Full
comment:
Sec.
18.
Expires
12/
31/
07
09023090
9B
Pumpkin,
seed
0.300000
1.000
1.000
Sec.
1
Full
comment:
Sec.
18.
Expires
12/
31/
07
09023570
9B
Squash,
winter
0.300000
1.000
1.000
Sec.
1
Full
comment:
Sec.
18.
Expires
12/
31/
07
09023571
9B
Squash,
winter­
babyfood
0.300000
1.000
1.000
Sec.
1
Full
comment:
Sec.
18.
Expires
12/
31/
07
95003590
O
Strawberry
0.900000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
95003591
O
Strawberry­
babyfood
0.900000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
95003600
O
Strawberry,
juice
0.900000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
95003601
O
Strawberry,
juice­
babyfood
0.900000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
09013990
9A
Watermelon
0.080000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
09014000
9A
Watermelon,
juice
0.080000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
Quinoxyfen
Dietary
Exposure
and
Risk
Assessment
DP
Number:
328363
PC
Code:
055459
______________________________________________________________________________________

Page
10
of
15
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
QUNIOXYFEN
(
1994­
98
data)
Residue
file
name:
C:\
Documents
and
Settings\
sstanton\
My
Documents\
DEEM­
FCID
Files\
Quinoxyfen\
Quinoxyfen
food
only.
R98
Adjustment
factor
#
2
NOT
used.
Analysis
Date
04­
13­
2006/
14:
15:
58
Residue
file
dated:
04­
13­
2006/
14:
15:
10/
8
Reference
dose
(
RfD,
Chronic)
=
.2
mg/
kg
bw/
day
COMMENT
1:
Chronic
dietary
assessment
(
FOOD
ONLY)
to
support
new
uses
on
lettuce,
strawberry,
pepper
&
melons.
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.002420
1.2%

U.
S.
Population
(
spring
season)
0.002537
1.3%
U.
S.
Population
(
summer
season)
0.002435
1.2%
U.
S.
Population
(
autumn
season)
0.002321
1.2%
U.
S.
Population
(
winter
season)
0.002394
1.2%

Northeast
region
0.002541
1.3%
Midwest
region
0.002484
1.2%
Southern
region
0.002080
1.0%
Western
region
0.002782
1.4%

Hispanics
0.002286
1.1%
Non­
hispanic
whites
0.002592
1.3%
Non­
hispanic
blacks
0.001521
0.8%
Non­
hisp/
non­
white/
non­
black
0.002476
1.2%

All
infants
(<
1
year)
0.000784
0.4%
Nursing
infants
0.000354
0.2%
Non­
nursing
infants
0.000947
0.5%
Children
1­
6
yrs
0.003287
1.6%
Children
7­
12
yrs
0.002367
1.2%

Females
13­
19
(
not
preg
or
nursing)
0.002069
1.0%
Females
20+
(
not
preg
or
nursing)
0.002540
1.3%
Females
13­
50
yrs
0.002542
1.3%
Females
13+
(
preg/
not
nursing)
0.002881
1.4%
Females
13+
(
nursing)
0.002636
1.3%

Males
13­
19
yrs
0.002023
1.0%
Males
20+
yrs
0.002234
1.1%
Seniors
55+
0.002166
1.1%

Children
1­
2
yrs
0.003662
1.8%
Children
3­
5
yrs
0.003294
1.6%
Children
6­
12
yrs
0.002390
1.2%
Youth
13­
19
yrs
0.002062
1.0%
Adults
20­
49
yrs
0.002486
1.2%
Adults
50+
yrs
0.002234
1.1%
Females
13­
49
yrs
0.002571
1.3%
Quinoxyfen
Dietary
Exposure
and
Risk
Assessment
DP
Number:
328363
PC
Code:
055459
______________________________________________________________________________________

Page
11
of
15
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
QUNIOXYFEN
1994­
98
data
Residue
file:
C:\
Documents
and
Settings\
sstanton\
My
Documents\
DEEM­
FCID
Files\
Quinoxyfen\
Quinoxyfen
water
only.
R98
Adjust.
#
2
NOT
used
Analysis
Date
04­
13­
2006
Residue
file
dated:
04­
13­
2006/
14:
45:
10/
8
Reference
dose
(
RfD)
=
0.2
mg/
kg
bw/
day
Comment:
Quinoxyfen
Drinking
Water
Chronic
Assessment.
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Food
Crop
Residue
Adj.
Factors
Comment
EPA
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
86010000
O
Water,
direct,
all
sources
0.008350
1.000
1.000
EFED
M
Full
comment:
EFED
Memo
of
3/
23/
2006
86020000
O
Water,
indirect,
all
sources
0.008350
1.000
1.000
EFED
M
Full
comment:
EFED
Memo
of
3/
23/
2006
Quinoxyfen
Dietary
Exposure
and
Risk
Assessment
DP
Number:
328363
PC
Code:
055459
______________________________________________________________________________________

Page
12
of
15
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
QUNIOXYFEN
(
1994­
98
data)
Residue
file
name:
C:\
Documents
and
Settings\
sstanton\
My
Documents\
DEEM­
FCID
Files\
Quinoxyfen\
Quinoxyfen
water
only.
R98
Adjustment
factor
#
2
NOT
used.
Analysis
Date
04­
13­
2006/
14:
45:
57
Residue
file
dated:
04­
13­
2006/
14:
45:
10/
8
Reference
dose
(
RfD,
Chronic)
=
.2
mg/
kg
bw/
day
COMMENT
1:
Quinoxyfen
Drinking
Water
Chronic
Assessment.
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.000176
0.1%

U.
S.
Population
(
spring
season)
0.000174
0.1%
U.
S.
Population
(
summer
season)
0.000189
0.1%
U.
S.
Population
(
autumn
season)
0.000170
0.1%
U.
S.
Population
(
winter
season)
0.000170
0.1%

Northeast
region
0.000161
0.1%
Midwest
region
0.000178
0.1%
Southern
region
0.000167
0.1%
Western
region
0.000202
0.1%

Hispanics
0.000200
0.1%
Non­
hispanic
whites
0.000172
0.1%
Non­
hispanic
blacks
0.000167
0.1%
Non­
hisp/
non­
white/
non­
black
0.000216
0.1%

All
infants
(<
1
year)
0.000577
0.3%
Nursing
infants
0.000214
0.1%
Non­
nursing
infants
0.000715
0.4%
Children
1­
6
yrs
0.000246
0.1%
Children
7­
12
yrs
0.000160
0.1%

Females
13­
19
(
not
preg
or
nursing)
0.000124
0.1%
Females
20+
(
not
preg
or
nursing)
0.000176
0.1%
Females
13­
50
yrs
0.000170
0.1%
Females
13+
(
preg/
not
nursing)
0.000171
0.1%
Females
13+
(
nursing)
0.000244
0.1%

Males
13­
19
yrs
0.000129
0.1%
Males
20+
yrs
0.000158
0.1%
Seniors
55+
0.000173
0.1%

Children
1­
2
yrs
0.000261
0.1%
Children
3­
5
yrs
0.000245
0.1%
Children
6­
12
yrs
0.000169
0.1%
Youth
13­
19
yrs
0.000127
0.1%
Adults
20­
49
yrs
0.000164
0.1%
Adults
50+
yrs
0.000173
0.1%
Females
13­
49
yrs
0.000164
0.1%
Quinoxyfen
Dietary
Exposure
and
Risk
Assessment
DP
Number:
328363
PC
Code:
055459
______________________________________________________________________________________

Page
13
of
15
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
QUNIOXYFEN
1994­
98
data
Residue
file:
C:\
Documents
and
Settings\
sstanton\
My
Documents\
DEEM­
FCID
Files\
Quinoxyfen\
Quinoxyfen.
R98
Adjust.
#
2
NOT
used
Analysis
Date
04­
12­
2006
Residue
file
dated:
04­
12­
2006/
09:
04:
14/
8
Reference
dose
(
RfD)
=
0.2
mg/
kg
bw/
day
Comment:
Chronic
dietary
assessment
to
support
new
uses
on
lettuce,
strawberry,
pepper
&
melons.
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Food
Crop
Residue
Adj.
Factors
Comment
EPA
Code
Grp
Food
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
09010750
9A
Cantaloupe
0.080000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
09010800
9A
Casaba
0.080000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
12000900
12
Cherry
0.300000
1.000
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
12000901
12
Cherry­
babyfood
0.300000
1.000
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
12000910
12
Cherry,
juice
0.300000
1.500
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
12000911
12
Cherry,
juice­
babyfood
0.300000
1.500
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
95001750
O
Grape
0.600000
1.000
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
95001760
O
Grape,
juice
0.600000
1.200
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
95001761
O
Grape,
juice­
babyfood
0.600000
1.200
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
95001770
O
Grape,
leaves
0.600000
1.000
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
95001780
O
Grape,
raisin
0.600000
4.300
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
95001790
O
Grape,
wine
and
sherry
0.600000
1.000
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
09011870
9A
Honeydew
melon
0.080000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
95001880
O
Hop
3.000000
1.000
1.000
Establ
Full
comment:
Established
Permanent
Tolerance
04012040
4A
Lettuce,
head
7.000000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
04012050
4A
Lettuce,
leaf
19.000000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
08002700
8
Pepper,
bell
0.350000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
08002701
8
Pepper,
bell­
babyfood
0.350000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
08002710
8
Pepper,
bell,
dried
0.350000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
08002711
8
Pepper,
bell,
dried­
babyfood
0.350000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
08002720
8
Pepper,
nonbell
1.700000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
08002721
8
Pepper,
nonbell­
babyfood
1.700000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
Quinoxyfen
Dietary
Exposure
and
Risk
Assessment
DP
Number:
328363
PC
Code:
055459
______________________________________________________________________________________

Page
14
of
15
08002730
8
Pepper,
nonbell,
dried
1.700000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
09023080
9B
Pumpkin
0.300000
1.000
1.000
Sec.
1
Full
comment:
Sec.
18.
Expires
12/
31/
07
09023090
9B
Pumpkin,
seed
0.300000
1.000
1.000
Sec.
1
Full
comment:
Sec.
18.
Expires
12/
31/
07
09023570
9B
Squash,
winter
0.300000
1.000
1.000
Sec.
1
Full
comment:
Sec.
18.
Expires
12/
31/
07
09023571
9B
Squash,
winter­
babyfood
0.300000
1.000
1.000
Sec.
1
Full
comment:
Sec.
18.
Expires
12/
31/
07
95003590
O
Strawberry
0.900000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
95003591
O
Strawberry­
babyfood
0.900000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
95003600
O
Strawberry,
juice
0.900000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
95003601
O
Strawberry,
juice­
babyfood
0.900000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
86010000
O
Water,
direct,
all
sources
0.008350
1.000
1.000
EFED
M
Full
comment:
EFED
Memo
of
3/
23/
2006
86020000
O
Water,
indirect,
all
sources
0.008350
1.000
1.000
EFED
M
Full
comment:
EFED
Memo
of
3/
23/
2006
09013990
9A
Watermelon
0.080000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
09014000
9A
Watermelon,
juice
0.080000
1.000
1.000
Pendin
Full
comment:
Pending
Tolerance
for
New
Use
Quinoxyfen
Dietary
Exposure
and
Risk
Assessment
DP
Number:
328363
PC
Code:
055459
______________________________________________________________________________________

Page
15
of
15
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
QUNIOXYFEN
(
1994­
98
data)
Residue
file
name:
C:\
Documents
and
Settings\
sstanton\
My
Documents\
DEEM­
FCID
Files\
Quinoxyfen\
Quinoxyfen.
R98
Adjustment
factor
#
2
NOT
used.
Analysis
Date
04­
12­
2006/
09:
12:
23
Residue
file
dated:
04­
12­
2006/
09:
04:
14/
8
Reference
dose
(
RfD,
Chronic)
=
.2
mg/
kg
bw/
day
COMMENT
1:
Chronic
dietary
assessment
to
support
new
uses
on
lettuce,
strawberry,
pepper
&
melons.
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.002596
1.3%

U.
S.
Population
(
spring
season)
0.002711
1.4%
U.
S.
Population
(
summer
season)
0.002624
1.3%
U.
S.
Population
(
autumn
season)
0.002491
1.2%
U.
S.
Population
(
winter
season)
0.002565
1.3%

Northeast
region
0.002702
1.4%
Midwest
region
0.002662
1.3%
Southern
region
0.002248
1.1%
Western
region
0.002984
1.5%

Hispanics
0.002485
1.2%
Non­
hispanic
whites
0.002764
1.4%
Non­
hispanic
blacks
0.001688
0.8%
Non­
hisp/
non­
white/
non­
black
0.002692
1.3%

All
infants
(<
1
year)
0.001361
0.7%
Nursing
infants
0.000568
0.3%
Non­
nursing
infants
0.001662
0.8%
Children
1­
6
yrs
0.003533
1.8%
Children
7­
12
yrs
0.002527
1.3%

Females
13­
19
(
not
preg
or
nursing)
0.002193
1.1%
Females
20+
(
not
preg
or
nursing)
0.002716
1.4%
Females
13­
50
yrs
0.002712
1.4%
Females
13+
(
preg/
not
nursing)
0.003052
1.5%
Females
13+
(
nursing)
0.002879
1.4%

Males
13­
19
yrs
0.002153
1.1%
Males
20+
yrs
0.002391
1.2%
Seniors
55+
0.002339
1.2%

Children
1­
2
yrs
0.003923
2.0%
Children
3­
5
yrs
0.003539
1.8%
Children
6­
12
yrs
0.002559
1.3%
Youth
13­
19
yrs
0.002189
1.1%
Adults
20­
49
yrs
0.002651
1.3%
Adults
50+
yrs
0.002407
1.2%
Females
13­
49
yrs
0.002734
1.4%