Document ID: EPA-HQ-OPPT-2009-0112-0016
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2010-02-25T05:00Z

SEQ CHAPTER \h \r 1 Testing of Certain High Production Volume
Chemicals; Third Group of Chemicals

(Exposure Findings Supporting Information)

U.S. Environmental Protection Agency 

Office of Pollution Prevention and Toxics 

Economics, Exposure and Technology Division 

December 2009Table of Contents

PREFACE

  TOC \o "1-3" \h \z \u    HYPERLINK \l "_Toc175984749"  1.0	Data Source
Descriptions	  PAGEREF _Toc175984749 \h  3  

  HYPERLINK \l "_Toc175984750"  2.0	Summary of HPV3 Chemicals and
Findings	  PAGEREF _Toc175984750 \h  4  

 Preface

	This findings document was prepared to support EPA’s Proposed TSCA
Section 4 Test Rule for Certain High Production Volume Chemicals; Third
Group of Chemicals.  Prior to promulgating a test rule under section 4
of the Toxic Substances Control Act (TSCA), 15 U.S.C. §§2601 et seq,
EPA is required to make certain findings identified in section 4(a) of
TSCA relating to the chemical’s risk and potential exposure, the
sufficiency of data to allow EPA to determine the human health or
environmental effects of the chemical, and the need to conduct testing.

 

	Under TSCA section 4(a)(1)(B), EPA must make the following findings to
support a test rule based on concerns for exposure: (1) that a chemical
substance is or will be produced in substantial quantities and that it
enters or may reasonably be anticipated to enter the environment in
substantial quantities and/or that there is or may be substantial and/or
significant human exposure to such substance; (2) that there are
insufficient data and experience upon which the effects of the
manufacture, distribution in commerce, processing, use or disposal of
such substance or mixture or of any combination of such activities on
health or the environment can reasonably be determined or predicted; and
(3) that testing of the substance or mixture with respect to such
effects is necessary to develop such data.  The criteria and standards
used by EPA for evaluating the terms “substantial production,”
“substantial release,” and “substantial or significant human
exposure” as used in TSCA section 4(a)(1)(B)(i) are explained in
EPA’s Final Statement of Policy; Criteria for Evaluating Substantial
Production, Substantial Release, and Substantial or Significant Human
Exposure set forth at 58 FR 28736 (May 14, 1993) (hereinafter referred
to as the “B Policy”).

	This document provides a detailed discussion of EPA’s evaluation of
each of the chemical substances identified in the proposed test rule to
determine that preliminary TSCA section 4(a)(1)(B) findings concerning
“substantial production,” “substantial release,” and
“substantial or significant human exposure” can be made. Data
Source Descriptions

TSCA Inventory Update Reporting Rule: In 1986, EPA promulgated the
Inventory Update Reporting (IUR) regulations, under TSCA section 8(a),
to facilitate the periodic updating of the TSCA Inventory database and
to otherwise support activities associated with implementing TSCA. As
originally promulgated, the IUR required chemical manufacturers
(including importers) to report to EPA every 4 years the identity of
chemical substances manufactured (including imported) annually in
quantities of 10,000 pounds or more at each plant site they owned or
controlled. In 2003 EPA adjusted the universe of chemicals and plant
sites that are required to report, and the type of information reported.
In 2005, EPA changed the reporting frequency to once every 5 years,
revised the manner in which amounts of a chemical substance manufactured
or imported must be reported, and changed the submission period for
reporting after 2006.

To protect the claims of confidential business information (CBI)
asserted by some IUR submitters on the amount of the chemical substance
manufactured (including imported) at a specific site, all production
volumes reported by IUR submitters (i.e., CBI and non-CBI) for each
chemical are combined by EPA for an aggregate total.  Confidential
business information claims are further protected by using eight ranges
to identify the total for any specific chemical and then making
available to the public the range that corresponds to the aggregate
production volume. Publicly-available information from the 1986, 1990,
1994, 1998, and 2002 (and 2006) IUR reporting cycles are available
on-line at:   HYPERLINK http://www.epa.gov/oppt/iur/index.htm
http://www.epa.gov/oppt/iur/index.htm 

The Toxics Release Inventory (TRI) contains information about releases
of certain chemicals and management of wastes at a wide variety of
sources, including manufacturing operations, certain service businesses,
and federal facilities.  Publicly-available information from the 2005
TRI reporting cycle is available on-line at:   HYPERLINK
http://www.epa.gov/triexplorer/ http://www.epa.gov/triexplorer/ 

The National Institute for Occupational Safety and Health (NIOSH)
conducted the National Occupational Exposure Survey (NOES) that
collected data on potential occupational exposures to chemical,
physical, and biological agents from 1981 to 1983.  The survey involved
on-site visits to 4,490 establishments in 522 industry types employing
approximately 1,800,000 workers in 377 occupational categories. 
Publicly-available information from the NOES is available on-line at:  
HYPERLINK http://www.cdc.gov/noes/default.html
http://www.cdc.gov/noes/default.html 

The National Library of Medicine Household Products Database provides
information on the chemical ingredients and their percentage in specific
brands of household products.  Information in the database is from a
variety of publicly available sources including brand-specific labels
and Material Safety Data Sheets when available from manufacturers and
manufacturers' web sites.  Publicly-available information from the
database is available on-line at:   HYPERLINK
http://householdproducts.nlm.nih.gov/
http://householdproducts.nlm.nih.gov/ 

Summary of HPV3 Chemicals and Findings

	Table 2-1 below presents a summary of the high production volume (HPV)
chemicals (29) and data collected to support an exposure-based finding.
Table 2-2 presents a chemical-by-chemical explanation of the supporting
findings information. Table 2-3 presents the chemicals (16) that did not
have sufficient exposure data needed to be included in this proposed
rule.

Table 2-1

Summary of Data Searched for Exposure Based Findings

	CAS#	Chemical Name	2006 IUR Production Volume

[Million lbs]	PAIR Production Volume

[Million lbs]	2006 IUR  -Substantial Human Exposure (>1,000 Workers) Met
PAIR - Substantial Human Exposure (>1,000 Workers) Met	NOES Number of
Workers	NLM Household Chemicals Database 	Non-CBI 2006 IUR Commercial/
Consumer Code Description	PAIR - Substantial Human Exposure (Consumer
Use Indicated)	PAIR - Substantial Release Criteria (>1 million lbs) Met 
2005 TRI Data(Total On- and Off-site Disposal or Other Releases, lbs)
Meet Exposure Based Criteria

for Workers	Meet Exposure Based Criteria for Consumers	Meet Exposure
Based Criteria for Release

1	83-41-0	2-Nitrobenzene, 1,2-dimethyl-	< 1	> 10 - 50

	Yes

Yes

2	96-22-0	3-Pentanone	> 10 - 50	> 10 - 50

Yes

Yes

	3	98-09-9	Benzenesulfonyl chloride	> 1 - 10	> 1 - 10

	851

C16-Rubber and plastic products	 

	Yes	Yes

	4	98-56-6	Benzene, 1-chloro-4-(trifluoromethyl)-	> 1 - 10	> 1 - 10

1 home maintenance product	Code(s) claimed CBI	 

	Yes	Yes

	5	111-44-4	Ethane, 1,1'-oxybis[2-chloro-	> 1 - 10	< 1

	C20-Other; Code(s) claimed CBI	 

412	Yes	Yes

	6	127-68-4	Benzenesulfonic acid, 3-nitro-, sodium salt (1:1)	> 1 - 10	<
1

	9,386

	 

	Yes

7	506-51-4	1-Tetracosanol	< 1	> 1 - 10

	1,281

	 

	Yes

18	506-52-5	1-Hexacosanol	< 1	> 1 - 10

	1,565

	 

	Yes

9	515-40-2	Benzene, (2-chloro-1,1-dimethylethyl)-	> 1 - 10	> 1 - 10

	C02-Agricultural products (non-pesticidal)	 

	Yes	Yes

	10	2494-89-5	Ethanol, 2-[(4-aminophenyl)sulfonyl]-, 1-(hydrogen
sulfate)	> 1 - 10	> 1 - 10

	Code(s) claimed CBI	 

	Yes	Yes

	11	5026-74-4	2-Oxiranemethanamine,
N-[4-(2-oxiranylmethoxy)phenyl]-N-(2-oxiranylmethyl)-	> 1 - 10	> 1 - 10
Yes

952

	 

	Yes

12	22527-63-5	Propanoic acid, 2-methyl-,
3-(benzoyloxy)-2,2,4-trimethylpentyl ester	> 1 - 10	> 1 - 10

	C16-Rubber and plastic products; Code(s) claimed CBI	Yes

	Yes	Yes

	13	24615-84-7	2-Propenoic acid, 2-carboxyethyl ester	> 1 - 10	< 1

	C20-Other	 

	Yes	Yes

	14	25321-41-9	Benzenesulfonic acid, dimethyl-	> 1 - 10	< 1

	2,843

Yes

15	25646-71-3	Methanesulfonamide,
N-[2-[(4-amino-3-methylphenyl)ethylamino]ethyl]-, sulfate (2:3)	> 1 - 10
< 1	Yes

C14-Photographic supplies	 

	Yes	Yes

	16	52556-42-0	1-Propanesulfonic acid, 2-hydroxy-3-(2-propen-1-yloxy)-,
sodium salt (1:1)	> 1 - 10	> 1 - 10	Yes

C20-Other	 

	Yes	Yes

	17	61788-76-9	Alkanes, chloro	> 10 - 50	> 1 - 10

	176,314

C01-Adhesives and sealants; C20-Other	 

	Yes	Yes

	18	65996-79-4	Solvent naphtha (coal)	> 10 - 50	> 10 - 50

	C20-Other	 

	Yes	Yes

	19	65996-82-9	Tar oils, coal	> 100 million - 1 billion	> 100 million -
1 billion

	C16-Rubber and plastic products; C19-Wood and wood furniture; C20-Other
 

	Yes	Yes

	20	65996-89-6	Tar, coal, high-temp.	> 1 billion lbs	> 1 billion lbs

Yes	761

C12-Paints and coatings; C20-Other	Yes	Yes

Yes	Yes	Yes

21	65996-92-1	Distillates (coal tar)	> 100 million - 1 billion	> 100
million - 1 billion

	C16-Rubber and plastic products; C19-Wood and wood furniture; C20-Other
 

	Yes	Yes

	22	68082-78-0	Lard, oil, Me esters	> 1 - 10	> 1 - 10

	41,153

	 

	Yes

23	68187-57-5	Pitch, coal tar-petroleum	> 100 million - 1 billion	> 100
million - 1 billion

	C11-Metal products	 

	Yes	Yes

	24	68442-60-4	Acetaldehyde, reaction products with formaldehyde,
by-products from	> 1 - 10	> 1 - 10

	Code(s) claimed CBI	Yes

	Yes	Yes

	25	68610-90-2	2-Butenedioic acid (2E)-, di-C8-18-alkyl esters	> 1 - 10
> 1 - 10

Yes

Yes

	26	68988-22-7	1,4-Benzenedicarboxylic acid, 1,4-dimethyl ester, manuf.
of, by-products from	> 10 - 50	> 10 - 50

 	Yes

Yes

27	70693-50-4	Phenol,
2,4-bis(1-methyl-1-phenylethyl)-6-[2-(2-nitrophenyl)diazenyl]-	> 1 - 10
> 1 - 10

	Code(s) claimed CBI	 

	Yes	Yes

	28	72162-15-3	1-Decene, sulfurized	> 1 - 10	< 1

	64,227

	 

	Yes

29	73665-18-6	Extract residues (coal), tar oil alk., naphthalene distn.
residues	> 50 - 100	> 100 million - 1 billion

	C19-Wood and wood furniture	 

	Yes	Yes

	Table 2-2

Chemical-by-Chemical Explanation of Findings 

CAS#	Chemical Name	Summary of Findings

83-41-0	2-Nitrobenzene, 1,2-dimethyl-	PAIR indicates >1 million lbs of
this chemical is released to the environment.  Based on this
information, this chemical would meet the exposure based findings
criteria of “significant or substantial release.”  

This chemical met exposure based findings criteria based on:

- PAIR Production Volume Range (10 million - 50 million lb)

- Substantial Release (Greater than 1 million lbs released)

96-22-0	3-Pentanone	PAIR indicates consumer use. It is possible that
products containing this chemical may be used by >10,000 consumers. 
Based on this information, this chemical would meet the exposure based
findings criteria of "substantial or significant human exposure.”

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (10 million - 50 million lb)

- Consumers potentially exceeding 10,000 people

98-09-9	Benzenesulfonyl chloride	The IUR commercial/consumer product
category C16-Rubber and plastic products was reported for this chemical.
Chemicals reporting in this category are contained in such products as
tires, footwear, flooring, bottles, sporting equipment, games, and toys.
It is expected that these products will be widely used by consumers
(including children) and hence, may likely exceed 10,000 people. 
Additionally, products such as tires and flooring are also used in a
commercial setting, which may lead to exposures of >1,000 commercial
workers.  Based on this information, this chemical would meet the
exposure based findings criteria of "substantial or significant human
exposure.”  (All stated IUR  commercial/consumer product categories
are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total  workers potentially exceeding 1,000 based on the IUR
commercial/consumer product categories (C16 ) 

- Consumers potentially exceeding 10,000 people based on IUR
commercial/consumer product category (C16)

98-56-6	Benzene, 1-chloro-4-(trifluoromethyl)-	The number of potentially
exposed consumers is estimated to be very large based on the use (home
maintenance product) cited in the NLM Household Chemicals Database.  It
is expected that home maintenance products will be widely used by
consumers and hence, may likely exceed 10,000 people.  Based on this
information, this chemical would meet the exposure based findings
criteria of "substantial or significant human exposure.”  

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Consumers potentially exceeding 10,000 people based on NLM Household
Chemicals Database

111-44-4	Ethane, 1,1'-oxybis[2-chloro-	The IUR commercial/consumer
product category C20-Other (chemicals contained in commercial and
consumer products not elsewhere classified) was reported for this
chemical. This indicates that this chemical is present in an unknown
number of commercial and consumer products that may potentially have a
high number of exposures. Based on this information, this chemical would
meet the exposure based findings criteria of "substantial or significant
human exposure.”  (All stated IUR  commercial/consumer product
categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR
commercial/consumer product category (C20) 

- Consumers potentially exceeding 10,000 people based on IUR
commercial/consumer product category (C20)

127-68-4	Benzenesulfonic acid, 3-nitro-, sodium salt (1:1)	The number of
potentially exposed total workers exceeds 1,000 based on NOES data.  The
production volume data for the 2006 IUR data collection was compared to
the production volume data for the 1986 IUR data collection for this
chemical to see if the production volume stayed the same or increased,
thereby indicating that the usage of these chemicals is no less than
when NOES data were gathered.  The 1986 reported IUR production volume
range was 1 million -10 million lbs. The 2006 IUR production volume
range is 1 million -10 million lbs.

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers exceeding 1,000 based NOES data (9,386 workers)

506-51-4	1-Tetracosanol	The number of potentially exposed total workers
exceeds 1,000 based on NOES data.  The production volume data for the
PAIR data collection was compared to the production volume data for the
1986 IUR data collection for this chemical to see if the production
volume stayed the same or increased, thereby indicating that the usage
of these chemicals is no less than when NOES data were gathered.  The
1986 reported IUR production volume range was 1 million -10 million lbs.
The PAIR production volume range is 1 million -10 million lbs.

This chemical met exposure based findings criteria based on:

- PAIR Production Volume Range (1 million - 10 million lb)

- Total workers exceeding 1,000 based NOES data (1,281 workers)

506-52-5	1-Hexacosanol	The number of potentially exposed total workers
exceeds 1,000 based on NOES data.  The production volume data for the
PAIR data collection was compared to the production volume data for the
1986 IUR data collection for this chemical to see if the production
volume stayed the same or increased, thereby indicating that the usage
of these chemicals is no less than when NOES data were gathered.  The
1986 reported IUR production volume range was 1 million -10 million lbs.
The PAIR production volume range is 1 million -10 million lbs.

This chemical met exposure based findings criteria based on:

- PAIR Production Volume Range (1 million - 10 million lb)

- Total workers exceeding 1,000 based NOES data (1,565 workers)

515-40-2	Benzene, (2-chloro-1,1-dimethylethyl)-	The IUR
commercial/consumer product category C02-Agricultural products
(non-pesticidal) was reported for this chemical.  Chemicals reporting in
this category are used to increase the productivity and quality of farm
crops; examples include fertilizers and soil conditioners.  It is
expected that these products will be widely used by commercial workers
and consumers and hence, may likely exceed 1,000 commercial workers and
10,000 consumers.  Based on this information, this chemical would meet
the exposure based findings criteria of "substantial or significant
human exposure.”  (All stated IUR  commercial/consumer product
categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total  workers potentially exceeding 1,000 based on the IUR
commercial/consumer product categories (C02 ) 

- Consumers potentially exceeding 10,000 people based on IUR
commercial/consumer product category (C02)

2494-89-5	Ethanol, 2-[(4-aminophenyl)sulfonyl]-, 1-(hydrogen sulfate)
The IUR commercial/consumer product category(s) was claimed CBI for this
chemical. This chemical is present in an unknown number of commercial
and consumer products that may potentially have a high number of
exposures. Based on this information, this chemical would meet the
exposure based findings criteria of "substantial or significant human
exposure.”  

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on  IUR
commercial/consumer product category(s) claimed CBI

- Consumers potentially exceeding 10,000 people based on IUR
commercial/consumer product category claimed CBI

5026-74-4	2-Oxiranemethanamine,
N-[4-(2-oxiranylmethoxy)phenyl]-N-(2-oxiranylmethyl)-	The total number
of potentially exposed workers is likely to exceed 1,000 based on
reported IUR data.  

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR data 

22527-63-5	Propanoic acid, 2-methyl-,
3-(benzoyloxy)-2,2,4-trimethylpentyl ester	The IUR commercial/consumer
product category C16-Rubber and plastic products was reported for this
chemical. Chemicals reporting in this category are contained in such
products as tires, footwear, flooring, bottles, sporting equipment,
games, and toys. It is expected that these products will be widely used
by consumers (including children) and hence, may likely exceed 10,000
people.  Additionally, products such as tires and flooring are also used
in a commercial setting, which may lead to exposures of >1,000
commercial workers.  Other product category(s) was claimed CBI.  Based
on this information, this chemical would meet the exposure based
findings criteria of "substantial or significant human exposure.” 
(All stated IUR  commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total  workers potentially exceeding 1,000 based on the IUR
commercial/consumer product categories (C16 ) 

- Consumers potentially exceeding 10,000 people based on IUR
commercial/consumer product category (C16)

24615-84-7	2-Propenoic acid, 2-carboxyethyl ester	The IUR
commercial/consumer product category C20-Other (chemicals contained in
commercial and consumer products not elsewhere classified) was reported
for this chemical. This indicates that this chemical is present in an
unknown number of commercial and consumer products that may potentially
have a high number of exposures. Based on this information, this
chemical would meet the exposure based findings criteria of "substantial
or significant human exposure.”  (All stated IUR  commercial/consumer
product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR
commercial/consumer product category (C20)

- Consumers potentially exceeding 10,000 people based on IUR
commercial/consumer product category (C20)

25321-41-9	Benzenesulfonic acid, dimethyl-	The total number of
potentially exposed workers exceeds 1,000 workers based on NOES data.
The production volume data for the 2006 IUR data collection was compared
to the production volume data for the 1986 IUR data collection for this
chemical to see if the production volume stayed the same or increased,
thereby indicating that the usage of these chemicals is no less than
when NOES data were gathered.  The 1986 reported IUR production volume
range was 1 million -10 million lbs.  The 2006 IUR production volume
range is 1 million -10 million lbs. 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers exceeding 1,000 based NOES data (2,843 workers)

25646-71-3	Methanesulfonamide,
N-[2-[(4-amino-3-methylphenyl)ethylamino]ethyl]-, sulfate (2:3)	The
total number of potentially exposed workers is likely to exceed 1,000
based on reported IUR data.  Additionally, the IUR commercial/consumer
product category C14-Photographic supplies was reported for this
chemical.  Chemicals reporting in this category are contained in
photographic apparatus, equipment and parts; film, paper, plates, and
prepared photographic chemicals for commercial and consumer use.  It is
expected that these products will be widely used by commercial workers
and consumers and hence, may likely exceed 1,000 commercial workers and
10,000 consumers.  Based on this information, this chemical would meet
the exposure based findings criteria of "substantial or significant
human exposure.”  (All stated IUR  commercial/consumer product
categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on IUR data and
commercial/consumer product category (C14)

- Consumers potentially exceeding 10,000 people based on IUR
commercial/consumer product category (C14)

52556-42-0	1-Propanesulfonic acid, 2-hydroxy-3-(2-propen-1-yloxy)-,
sodium salt (1:1)	The IUR commercial/consumer product category C20-Other
(chemicals contained in commercial and consumer products not elsewhere
classified) was reported for this chemical. This indicates that this
chemical is present in an unknown number of commercial and consumer
products that may potentially have a high number of exposures. Based on
this information, this chemical would meet the exposure based findings
criteria of "substantial or significant human exposure.”  (All stated
IUR  commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on  IUR
commercial/consumer product category (C20)

- Consumers potentially exceeding 10,000 people based on IUR
commercial/consumer product category (C20)

61788-76-9	Alkanes, chloro	The total number of potentially exposed
workers exceeds 1,000 workers based on NOES data. Additionally, the
number of potentially exposed consumers is estimated to be very large
based on the reported IUR commercial/consumer product categories for
this chemical: C01-Adhesives and sealants, and C20-Other (chemicals
contained in commercial and consumer products not elsewhere classified).
Chemicals reporting in these product categories are contained in
industrial and household adhesives, glues, caulking compounds, and
sealants, along with an unknown number of commercial and consumer
products that may potentially have a high number of exposures.  It is
expected that these products will be widely used by commercial workers
and consumers and hence, may likely exceed 1,000 commercial workers and
10,000 consumers.  Based on this information, this chemical would meet
the exposure based findings criteria of "substantial or significant
human exposure.” The production volume data for the 2006 IUR data
collection was compared to the production volume data for the 1986 IUR
data collection for this chemical to see if the production volume stayed
the same or increased, thereby indicating that the usage of these
chemicals is no less than when NOES data were gathered.  The 1986
reported IUR production volume range was 1 million -10 million lbs. The
2006 IUR production volume range is 10 million -50 million lbs. (All
stated IUR  commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (10 million - 50 million lb)

- Total workers exceeding 1,000 based NOES data (176,314 workers)

- Total workers potentially exceeding 1,000 based on  IUR
commercial/consumer product categories (C01, C20)

- Consumers potentially exceeding 10,000 people based on IUR
commercial/consumer product category (C01, C20)

65996-79-4	Solvent naphtha (coal)	The IUR commercial/consumer product
category C20-Other (chemicals contained in commercial and consumer
products not elsewhere classified) was reported for this chemical. This
indicates that this chemical is present in an unknown number of
commercial and consumer products that may potentially have a high number
of exposures. Based on this information, this chemical would meet the
exposure based findings criteria of "substantial or significant human
exposure.”  (All stated IUR  commercial/consumer product categories
are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (10 million - 50 million lb)

- Total workers potentially exceeding 1,000 based on  IUR
commercial/consumer product category (C20)

- Consumers potentially exceeding 10,000 people based on IUR
commercial/consumer product category (C20)

65996-82-9	Tar oils, coal	The IUR commercial/consumer product categories
C16-Rubber and plastic products, C19-Wood and wood furniture, and
C20-Other (chemicals contained in commercial and consumer products not
elsewhere classified) were reported for this chemical. Chemicals
reporting in these product categories are contained in tires, footwear,
flooring, bottles, sporting equipment, games, toys, wood products and
wood furniture, along with an unknown number of commercial and consumer
products that may potentially have a high number of exposures.  It is
expected that these products will be widely used by commercial workers
and consumers and hence, may likely exceed 1,000 commercial workers and
10,000 consumers.  Based on this information, this chemical would meet
the exposure based findings criteria of "substantial or significant
human exposure.”  (All stated IUR  commercial/consumer product
categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (100 million - 1 billion lb)

- Total workers potentially exceeding 1,000 based on IUR
commercial/consumer product categories (C16, C19, C20)

- Consumers potentially exceeding 10,000 people based on IUR
commercial/consumer product category (C16,C19,C20)

65996-89-6	Tar, coal, high-temp.	The total number of potentially exposed
workers is likely to exceed 1,000 based on reported PAIR data. 
Additionally, the number of potentially exposed consumers is estimated
to be very large based on the reported IUR commercial/consumer product
categories for this chemical: C12-Paints and coatings, and C20-Other
(chemicals contained in commercial and consumer products not elsewhere
classified). Chemicals reporting in these product categories are
commercial and consumer paints (paste or ready-mix) including artists’
paints, varnishes, lacquers, enamels and shellac, paint and varnish
removers and cleaners, along with an unknown number of commercial and
consumer products that may potentially have a high number of exposures. 
It is expected that these products will be widely used by commercial
workers and consumers and hence, may likely exceed 1,000 commercial
workers and 10,000 consumers.  PAIR indicates >1 million lbs of this
chemical is released to the environment.  Based on this information,
this chemical would meet the exposure based findings criteria of
"substantial or significant human exposure" and “significant or
substantial release.”  (All stated IUR  commercial/consumer product
categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (> 1 billion lb)

- Total workers potentially exceeding 1,000 based on PAIR data

- Total workers potentially exceeding 1,000  based on the IUR
commercial/consumer product categories (C12, C20 )

- Consumers potentially exceeding 10,000 people based on IUR
commercial/consumer product category (C12,C20)

- Substantial Release (Greater than 1 million lbs released)

65996-92-1	Distillates (coal tar)	The IUR commercial/consumer product
categories C16-Rubber and plastic products, C19-Wood and wood furniture,
and C20-Other (chemicals contained in commercial and consumer products
not elsewhere classified) were reported for this chemical. Chemicals
reporting in these product categories are contained in tires, footwear,
flooring, bottles, sporting equipment, games, toys, wood products and
wood furniture, along with an unknown number of commercial and consumer
products that may potentially have a high number of exposures.  It is
expected that these products will be widely used by commercial workers
and consumers and hence, may likely exceed 1,000 commercial workers and
10,000 consumers.  Based on this information, this chemical would meet
the exposure based findings criteria of "substantial or significant
human exposure.”  (All stated IUR  commercial/consumer product
categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (100 million - 1 billion lb)

- Total workers potentially exceeding 1,000 based on IUR
commercial/consumer product categories (C16, C19, C20)

- Consumers potentially exceeding 10,000 people based on IUR
commercial/consumer product category (C16,C19, C20)

68082-78-0	Lard, oil, Me esters	The total number of potentially exposed
workers exceeds 1,000 workers based on NOES data. The production volume
data for the 2006 IUR data collection was compared to the production
volume data for the 1986 IUR data collection for this chemical to see if
the production volume stayed the same or increased, thereby indicating
that the usage of these chemicals is no less than when NOES data were
gathered.  The 1986 reported IUR production volume range was 500
thousand - 1 million lbs. The 2006 IUR production volume range is 1
million -10 million lbs. 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers exceeding 1,000 based NOES data 

  (41,153 workers)

68187-57-5	Pitch, coal tar-petroleum	The IUR commercial/consumer product
category C11-Metal products was reported for this chemical.  Chemicals
reporting in this category are contained in metal products for
commercial and consumer use; metal furniture and furnishings are
included in this category.  It is expected that these products will be
widely used by commercial workers and consumers (including children) and
hence, may likely exceed 1,000 commercial workers and 10,000 consumers. 
Based on this information, this chemical would meet the exposure based
findings criteria of "substantial or significant human exposure.” 
(All stated IUR  commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (100 million - 1 billion lb)

- Total workers potentially exceeding 1,000 based on IUR
commercial/consumer product category (C11)

- Consumers potentially exceeding 10,000 people based on IUR
commercial/consumer product category (C11)

68442-60-4	Acetaldehyde, reaction products with formaldehyde,
by-products from	The IUR commercial/consumer product category(s) was
claimed CBI for this chemical. This chemical is present in an unknown
number of commercial and consumer products that may potentially have a
high number of exposures.  Additionally, PAIR indicates consumer use. It
is possible that products containing this chemical may be used by
>10,000 consumers. Based on this information, this chemical would meet
the exposure based findings criteria of "substantial or significant
human exposure.”  

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on  IUR
commercial/consumer product category(s) claimed CBI

- Consumers potentially exceeding 10,000 people based on IUR
commercial/consumer product category claimed CBI

68609-05-2	Cyclohexane, oxidized	

This chemical met one exposure based findings criterion:

- PAIR Production Volume Range (1 million -10 million lb)

68610-90-2	2-Butenedioic acid (2E)-, di-C8-18-alkyl esters	PAIR
indicates consumer use.  It is possible that products containing this
chemical may be used by >10,000 consumers.  Based on this information,
this chemical would meet the exposure based findings criteria of
"substantial or significant human exposure.”  

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Consumers potentially exceeding 10,000 people

68988-22-7	1,4-Benzenedicarboxylic acid, 1,4-dimethyl ester, manuf. of,
by-products from	PAIR indicates >1 million lbs of this chemical is
released to the environment.  Based on this information, this chemical
would meet the exposure based findings criteria of “significant or
substantial release.”  

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (10 million - 50 million lb)

- Substantial Release (Greater than 1 million lbs released)

70693-50-4	Phenol,
2,4-bis(1-methyl-1-phenylethyl)-6-[2-(2-nitrophenyl)diazenyl]-	The IUR
commercial/consumer product category(s) was claimed CBI for this
chemical. This chemical is present in an unknown number of commercial
and consumer products that may potentially have a high number of
exposures. Based on this information, this chemical would meet the
exposure based findings criteria of "substantial or significant human
exposure.”  

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers potentially exceeding 1,000 based on  IUR
commercial/consumer product category(s) claimed CBI

- Consumers potentially exceeding 10,000 people based on IUR
commercial/consumer product category claimed CBI

72162-15-3	1-Decene, sulfurized	The total number of potentially exposed
workers exceeds 1,000 workers based on NOES data. The production volume
data for the 2006 IUR data collection was compared to the production
volume data for the 1986 IUR data collection for this chemical to see if
the production volume stayed the same or increased, thereby indicating
that the usage of these chemicals is no less than when NOES data were
gathered.  The 1986 reported IUR production volume range was 1 million -
10 million lbs. The 2006 IUR production volume range is 1 million -10
million lbs. 

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (1 million - 10 million lb)

- Total workers exceeding 1,000 based NOES data (64,227 workers)

73665-18-6	Extract residues (coal), tar oil alk., naphthalene distn.
residues	The IUR commercial/consumer product category C19-Wood and wood
furniture was reported for this chemical.  Chemicals reporting in this
category are contained in wood products and wood furniture for
commercial and consumer use.  It is expected that these products will be
widely used by commercial workers and consumers (including children) and
hence, may likely exceed 1,000 commercial workers and 10,000 consumers. 
Based on this information, this chemical would meet the exposure based
findings criteria of "substantial or significant human exposure.” 
(All stated IUR  commercial/consumer product categories are non-CBI)

This chemical met exposure based findings criteria based on:

- 2006 IUR Production Volume Range (50 million - 100 million lb)

- Total  workers potentially exceeding 1,000 based on the IUR
commercial/consumer product categories (C19 ) 

- Consumers potentially exceeding 10,000 people based on IUR
commercial/consumer product category (C19)



Table 2-3

HPV Orphan Chemicals Not Included in Third Group of Chemicals

	CAS#	Chemical Name

1	98-16-8	Benzenamine, 3-(trifluoromethyl)-

2	124-63-0	Methanesulfonyl chloride

3	460-00-4	Benzene, 1-bromo-4-fluoro-

4	542-92-7	1,3-Cyclopentadiene

5	928-72-3	Glycine, N-(carboxymethyl)-, sodium salt (1:2)

6	1738-25-6	Propanenitrile, 3-(dimethylamino)-

7	28106-30-1	Benzene, ethenylethyl-

8	35203-06-6	Benzenamine, 2-ethyl-6-methyl-N-methylene-

9	35203-08-8	Benzenamine, 2,6-diethyl-N-methylene-

10	37734-45-5	Carbonochloridothioic acid, S-(phenylmethyl) ester

11	37764-25-3	Acetamide, 2,2-dichloro-N,N-di-2-propen-1-yl-

12	68609-05-2	Cyclohexane, oxidized

13	65996-91-0	Distillates (coal tar), upper

14	68153-60-6	Fatty acids, tall-oil, reaction products with
diethylenetriamine, acetates

15	68442-77-3	2-Butenediamide, (2E)-,
N1,N4-bis[2-(4,5-dihydro-2-nortall-oil alkyl-1H-imidazol-1-yl)ethyl]
derivs.

16	68909-77-3	Ethanol, 2,2'-oxybis-, reaction products with ammonia,
morpholine derivs. residues

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Table 2-1 (Continued)

	                        

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