Document ID: EPA-HQ-OPPT-2002-0054-0263
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2002-11-21T05:00Z

Technical
Support
Document
Methodology
Used
for
the
Initial
Selection
of
Chemicals
for
the
Inventory
Update
Rule
Amendments
(
IURA)
"
Low
Current
Interest"
Partial
Reporting
Exemption
U.
S.
Environmental
Protection
Agency
Office
of
Pollution
Prevention
and
Toxics
August
27,
2002
1
Background
In
the
Inventory
Update
Rule
Amendments
(
IURA)
proposed
rule,
EPA
specifically
sought
comment
on
a
partial
reporting
exemption
for
"
low
priority"
chemicals.
This
partial
exemption
was
envisioned
to
remove
processing
and
use
information
reporting
requirements
for
certain
chemicals
manufactured
or
imported
in
quantities
of
300,000
lbs./
yr.
or
more
at
a
single
site.
In
the
proposal,
EPA
requested
comment
on
the
criteria
the
Agency
might
use
to
establish
such
an
exemption,
as
well
as
the
specific
chemicals
that
might
qualify
for
such
an
exemption.
A
number
of
commenters
supported
the
creation
of
a
partial
exemption,
and
several
provided
suggestions
for
chemical
substances
or
classes
of
substances
that
they
wanted
EPA
to
consider
including
in
this
or
in
an
expanded
partial
exemption
in
the
final
rulemaking.

In
response
to
the
comments
received,
EPA
has
established
a
partial
exemption
that
applies
when
EPA
has
determined
that
there
is
a
low
current
interest
in
a
listed
chemical's
IURA
processing
and
use
information.
In
the
final
rule,
EPA
is
also
establishing
a
process
for
revising
the
list
of
exempted
chemical
substances
over
time.

Because
IURA
reporting
is
chemical
specific,
this
low
current
interest
partial
exemption
applies
to
specific,
listed
chemical
substances.
The
methodology
that
EPA
used
to
identify
the
chemicals
initially
qualifying
for
this
partial
exemption
is
described
in
detail
below.
The
inclusion
of
a
chemical
substance
under
this
partial
exemption,
whether
on
the
initial
list
or
as
a
subsequent
change
to
the
list,
should
not
be
interpreted
to
indicate
low
potential
risks
for
that
chemical.

This
partial
exemption
is
intended
to
provide
a
tool
to
assist
the
Agency
in
better
managing
the
collection
of
processing
and
use
information
under
the
IURA.
Developed
primarily
as
an
effort
to
improve
IURA's
efficiency
and
effectiveness,
this
partial
exemption
also
provides
benefits
in
reducing
the
potential
reporting
burden
of
the
IURA
for
certain
manufacturers
of
these
chemicals.
The
Agency
still
intends
to
collect
IURA
processing
and
use
information
across
a
relatively
broad
set
of
chemicals
on
the
TSCA
Inventory.

IURA
to
Include
Process
to
Revise
List
of
Exempted
Chemicals
The
need
for
EPA's
collection
of
the
IURA
processing
and
use
information
related
to
a
particular
chemical
substance
can
change
over
time.
To
address
this
situation,
EPA
has
established
a
process
that
will
allow
for
revisions
(
additions
and
deletions)
to
the
list
of
exempted
chemical
substances.
The
process
allows
anyone
to
submit
a
written
request
for
EPA
to
consider
revising
the
list
of
chemical
substances
covered
under
this
partial
exemption.
EPA
may
also
revise
the
list
on
its
own
initiative.
When
a
list
revision
is
necessary,
EPA's
preferred
approach
will
be
to
issue
a
direct
final
rule,
which
affords
an
opportunity
for
public
comment,
while
providing
an
efficient
mechanism
for
revising
the
list.

In
determining
whether
there
is
a
low
current
interest
in
the
IURA
processing
and
use
information
related
to
a
specific
chemical
substance,
EPA
will
look
to
the
specific
circumstances
surrounding
the
chemical
in
question,
and
may
use
one
or
more
of
the
considerations
identified
below,
and/
or
considerations
not
identified
below,
to
make
an
informed
decision.
EPA
will
consider
the
totality
of
information
available
for
the
chemical
substance,
including
but
not
limited
to
the
following:

(
A)
Whether
the
chemical
qualifies
or
has
qualified
in
past
IUR
collections
for
the
reporting
of
2
the
information
described
in
40
CFR
710.52(
c)(
4)
(
i.
e.,
at
least
one
site
manufactures
300,000
pounds
or
more
of
the
chemical).

(
B)
The
chemical
substance's
chemical
and
physical
properties
or
potential
for
persistence,
bioaccumulation,
health
effects,
or
environmental
effects
(
considered
independently
or
together).

(
C)
The
information
needs
of
EPA
(
including
as
evidenced
by
ongoing
EPA
activities),
other
federal
agencies,
tribes,
states,
and
local
governments,
as
well
as
members
of
the
public.

(
D)
The
availability
of
other
complementary
risk
screening
information.

(
E)
The
availability
of
comparable
processing
and
use
information.

(
F)
Whether
the
potential
risks
of
the
chemical
substance
are
adequately
managed
by
EPA
or
another
Agency
or
authority.

It
is
important
to
reiterate
that
the
inclusion
of
these
chemical
substances
under
this
partial
exemption
is
not
based
on
the
potential
risks
of
the
chemicals,
but
is
based
on
the
Agency's
current
determination
of
the
need
for
collecting
IURA
processing
and
use
information.
Additionally,
some
of
the
chemicals
included
under
the
exemption
may
present
issues
that
will
renew
interest
in
them
in
the
future,
at
which
time
EPA
will
reconsider
the
applicability
of
this
partial
exemption
for
those
chemicals.

Any
person
may
use
the
process
established
in
40
CFR
710.46(
b)(
2)
to
submit
a
request
for
the
Agency
to
consider
other
chemical
substances
for
inclusion
under
or
removal
from
this
partial
exemption.
Requests
should
contain
sufficient
information
to
enable
EPA
to
make
the
necessary
determination
after
considering
the
totality
of
available
information.

Under
the
list
revision
process,
EPA
intends
to
provide
a
written
response
to
requests
within
120
days
of
receipt,
and
will
maintain
copies
of
these
responses
in
a
public
docket
that
will
be
established
for
each
reporting
cycle.
In
order
to
assist
the
Agency
in
completing
any
necessary
revisions
to
the
list
before
the
reporting
period,
any
request
for
revising
the
list
of
chemicals
under
this
partial
exemption
must
be
received
by
the
Agency
no
later
than
January
1
of
the
year
before
the
reporting
period
in
question
(
i.
e.,
12
months
prior
to
the
reporting
period).
For
example,
any
request
for
inclusion
under
this
partial
exemption
must
be
submitted
to
EPA
no
later
than
January
1,
2004,
i.
e.,
12
months
prior
to
the
next
reporting
period,
which
begins
on
January
1,
2005
for
the
2006
submission
period.
If
the
request
is
submitted
after
this
date,
during
an
actual
reporting
period,
or
during
the
submission
period,
EPA
is
less
likely
to
have
sufficient
time
to
complete
its
evaluation
and
make
a
determination,
or
issue
the
necessary
rulemaking
such
that
the
decision
can
be
effective
for
that
reporting
period.
IURA
submitters
should
check
the
Federal
Register
for
list
revisions
or
may
check
the
electronic
CFR
to
identify
what
chemicals
are
on
the
partial
exemption
list
prior
to
each
reporting
period.
3
Development
of
an
Initial
List
of
Exempted
Chemicals
To
create
an
initial
list
of
specific
chemical
substances
covered
by
this
partial
exemption,
EPA
started
with:

(
1)
The
list
of
chemical
substances
identified
as
part
of
the
U.
S.
HPV
Challenge
Program
as
of
June
1,
2002,
for
which,
based
upon
a
preliminary
review
of
known
hazard
information,
it
was
determined
that
the
SIDS
data
set
would
not
further
our
understanding
of
the
chemical's
properties
(
see
Table
1
below).

Chemical
manufacturers
and
importers
participating
in
the
HPV
Challenge
Program
have
voluntarily
agreed
to
provide
basic
toxicity
and
environmental
fate
information
on
their
sponsored
high
production
volume
(
HPV)
chemicals.
HPV
chemicals
are
those
chemicals
which
are
produced
in/
imported
into
the
U.
S.
in
amounts
of
1
million
pounds
per
year
or
more.
The
HPV
chemicals
that
were
originally
included
in
the
HPV
Challenge
Program
are
those
chemicals
which
were
HPV
according
to
1990
IUR
data.
The
information
generated
through
the
voluntary
HPV
Challenge
Program
will
be
made
available
to
the
public.
The
HPV
Challenge
Program
uses
the
same
endpoints,
testing
protocols,
and
basic
information
summary
formats
employed
by
the
Organization
for
Economic
Cooperation
and
Development's
(
OECD's)
HPV
Screening
Information
Data
Set
(
SIDS)
program.
More
information
on
the
HPV
Challenge
Program
can
be
found
at:
http://
www.
epa.
gov/
opptintr/
chemrtk/
volchall.
htm.

The
OECD
HPV
SIDS
Program
is
a
cooperative,
international
effort
to
develop
basic
toxicity
and
environmental
fate
information
resulting
in
the
creation
of
hazard­
based,
screening­
level
assessments
for
review
by
participating
OECD
member
countries.
The
International
Council
of
Chemical
Associations
(
ICCA)
administers
a
complementary
initiative
in
which
1,000
high
priority
chemicals
are
to
be
assessed
by
the
year
2004
within
the
framework
of
the
OECD
HPV
SIDS
Program.
The
ICCA
consists
of
representatives
chemical
associations
from
the
United
States,
Europe,
Japan,
Australia,
Canada,
Mexico,
Brazil,
New
Zealand,
and
Argentina.
Based
on
assembled
data
(
dossiers),
screening
level
risk
assessments
are
prepared
by
industry
and
submitted
via
the
sponsor
country
to
the
OECD
through
the
SIDS
Program
for
review
and
concurrence.
Agreed
upon
documents
are
then
made
publicly
available
at:
http://
irptc.
unep.
ch/
irptc/
sids/
sidspub.
html
Through
these
voluntary
efforts,
the
HPV
Challenge
Program
and
the
OECD
work
(
including
the
ICCA
initiative),
industry,
governments
and
others
are
working
to
collect
agreed
upon
information
and
accelerate
the
pace
of
making
data
available
to
the
public.
Because
these
efforts
are
largely
complementary
of
one
another,
EPA
does
not
plan
to
address,
under
the
U.
S.
HPV
Challenge
Program,
chemicals
which
are
sponsored
under
the
OECD
SIDS
Program
(
including
the
ICCA
initiative).

(
2)
The
list
of
the
chemical
substances
that
the
European
Union
(
EU)
exempted
from
provisions
of
its
Existing
Chemicals
Program.

In
1993
the
EU
Council
adopted
Council
Regulation
(
EEC)
793/
9,
known
as
the
Existing
Substances
Regulation
(
ESR),
thereby
introducing
a
comprehensive
framework
for
the
4
evaluation
and
control
of
"
existing"
chemical
substances.
An
"
existing"
chemical
substance
in
the
EU
is
defined
as
any
chemical
substance
listed
in
the
European
INventory
of
Existing
Commercial
Substances
(
EINECS),
an
inventory
containing
approximately
100,195
substances.
Regulation
793/
93
foresees
that
the
evaluation
and
control
of
the
risks
posed
by
existing
chemicals
will
be
carried
out
in
four
steps:
data
collection,
priority
setting,
risk
assessment,
and
risk
reduction.
Annex
II
to
this
regulation
exempts
certain
chemicals
from
certain
data
reporting
provisions
of
the
regulation
(
see
Table
3
below).
These
data
reporting
provisions
are
similar
to
those
of
the
HPV
Challenge
Program.
More
information
on
the
EU
Existing
Chemical
program
may
be
found
at:
http://
ecb.
jrc.
it/
existing­
chemicals/

(
3)
Certain
other
chemicals
identified
during
the
E.
O.
12866
interagency
review,
for
which
EPA
was
able
to
quickly
determine,
based
on
a
review
of
their
chemical
structures,
properties,
existing
hazard
information,
and
available
exposure
information,
that
IURA
processing
and
use
information
is
of
low
current
interest.

The
above
lists
were
then
adjusted
based
upon
the
totality
of
information
available
to
EPA
during
the
EO
12866
interagency
review
period
to
ensure
that
the
chemicals
included
in
this
partial
exemption
were
those
for
which
EPA
determined
that
the
IURA
processing
and
use
information
is
of
low
current
interest.
EPA
chose
these
initial
lists
of
chemicals
because
almost
all
had
previously
undergone
a
review
prior
to
their
inclusion
on
these
lists
and,
considering
the
limited
time
available
during
the
EO
12866
interagency
review,
the
Agency
was
able
to
utilize
these
lists,
along
with
the
Agency's
current
knowledge
and
understanding
of
the
individual
chemical's
structure,
properties,
indications
of
hazards
and
potential
exposures,
to
inform
its
determination
that
there
is
a
low
current
interest
in
the
IURA
processing
and
use
information
for
these
specific
chemicals.
As
indicated
previously,
EPA
has
established
a
process
for
revising
the
list
of
chemicals
covered
by
this
partial
exemption,
and
intends
to
reconsider
this
set
of
chemicals
as
well
as
others
identified
in
comments
for
applicability
under
this
partial
exemption
in
the
context
of
the
first
reporting
cycle
for
IURA
processing
and
use
information.

Adjustments
to
List
of
Chemical
Substances
Identified
as
Part
of
the
HPV
Challenge
Program
for
Which
It
Was
Determined
that
the
SIDS
Data
Set
Would
Not
Further
Our
Understanding
of
the
Chemical's
Properties
During
the
development
and
launch
of
the
HPV
Challenge
Program,
EPA
identified
a
list
of
chemical
substances
for
which
it
was
determined
that
the
SIDS
Data
Set
would
not
further
the
understanding
of
the
chemical's
properties.
Therefore,
these
chemicals
are
not
considered
candidates
for
testing
under
the
HPV
Challenge
Program,
although
their
sponsorship
in
the
HPV
Challenge
Program
by
their
manufacturers
is
welcome.
Table
1
is
a
list
of
these
chemical
substances.

Table
1
also
notes
two
chemicals
that
are
sponsored
by
their
manufacturers
under
the
HPV
Challenge
or
the
complementary
initiative
administered
by
the
ICCA.
EPA
views
the
sponsorship
of
chemicals
in
the
HPV
Challenge
Program
(
and
the
OECD
SIDS
Program,
including
the
ICCA
initiative)
as
significant
commitments
and
an
indication
of
ongoing
interest
in
the
chemical.
In
addition,
because
these
sponsorships
will
result
in
the
availability
of
complementary
risk
screening
information,
EPA
believes
that
the
two
chemicals
noted
in
Table
1
as
sponsored
under
the
HPV
Challenge
Program
and
the
ICCA
Initiative
should
not
be
considered
low
current
interest
chemicals
for
purposes
of
IURA
processing
and
use
information
reporting.
5
Therefore,
EPA
has
determined
that
the
chemicals
listed
in
Table
2
for
which
it
had
been
determined
that
the
SIDS
data
set
would
not
further
our
understanding
of
the
chemical's
properties,
and
are
not
otherwise
sponsored
under
the
HPV
Challenge
Program,
are
chemicals
that
are
of
low
current
interest,
and
are
to
be
excluded
from
IURA
processing
and
use
information
reporting
requirements.

Table
1
Chemical
Substances
Identified
as
Part
of
the
HPV
Challenge
Program
for
Which
It
Was
Determined
that
the
SIDS
Data
Set
Would
Not
Further
Our
Understanding
of
the
Chemical's
Properties
CAS
Number
Chemical
Name
50­
70­
4
Glucitol,
D­
50­
99­
7
D­
Glucose
(
note
1)
56­
81­
5
Glycerol
57­
50­
1
Sucrose
59­
02­
9
2H­
1­
Benzopyran­
6­
ol,
3,4­
dihydro­
2,5,7,8­
tetramethyl­
2­(
4,8,12­
trimethyltridecyl)­,
[
2R­[
2R*(
4R*,
8R*)]]­
69­
65­
8
Mannitol,
D­
124­
38­
9
Carbon
dioxide
142­
47­
2
Glutamic
acid,
monosodium
salt,
L­
1592­
23­
0
Stearic
acid,
calcium
salt
7440­
44­
0
Carbon
8001­
21­
6
Sunflower
oil
8001­
22­
7
Soybean
oil
8001­
26­
1
Linseed
oil
8001­
29­
4
Cottonseed
oil
8001­
30­
7
Corn
oil
8001­
31­
8
Coconut
oil
8001­
78­
3
Castor
oil,
hydrogenated
8001­
79­
4
Castor
oil
8002­
03­
7
Peanut
oil
8002­
75­
3
Palm
oil
8006­
54­
0
Lanolin
8016­
28­
2
Lard
oil
8016­
70­
4
Soybean
oil,
hydrogenated
8021­
99­
6
Charcoal,
bone
8029­
43­
4
Syrups,
hydrolyzed
starch
9050­
36­
6
Maltodextrin
16291­
96­
6
Charcoal
(
note
2)
61788­
61­
2
Fatty
acids,
tallow,
Me
esters
61789­
97­
7
Tallow
61789­
99­
9
Lard
64147­
40­
6
Castor
oil,
dehydrated
64755­
01­
7
Fatty
acids,
tallow,
calcium
salts
65996­
63­
6
Starch,
acid­
hydrolyzed
65996­
64­
7
Starch,
enzyme­
hydrolyzed
68188­
81­
8
Grease,
poultry
68334­
00­
9
Cottonseed
oil,
hydrogenated
68334­
28­
1
Fats
and
Glyceridic
oils,
vegetable,
hydrogenated
68409­
76­
7
Bone
meal,
steamed
68425­
17­
2
Syrups,
hydrolyzed
starch,
hydrogenated
68439­
86­
1
Bone,
ash
68476­
78­
8
Molasses
68514­
27­
2
Grease,
catch
basin
68514­
74­
9
Palm
oil,
hydrogenated
68525­
87­
1
Corn
oil,
hydrogenated
68918­
42­
3
Soaps,
stocks,
soya
68952­
94­
3
Soaps,
stocks,
vegetable­
oil
68989­
98­
0
Fats
and
Glyceridic
oils,
vegetable,
residues
73138­
67­
7
Lard,
hydrogenated
_______________________
note
1
=
this
chemical
was
sponsored
under
the
ICCA
Program
note
2
=
this
chemical
was
sponsored
under
the
HPV
Challenge
Program
6
Table
2
Chemical
Substances
Identified
as
Part
of
the
HPV
Challenge
Program
for
Which
It
Was
Determined
that
the
SIDS
Data
Set
Would
Not
Further
Our
Understanding
of
the
Chemical's
Properties
and
Which
Are
Not
Otherwise
Sponsored
Under
the
HPV
Challenge
Program
(
Included
in
the
Initial
IURA
Low
Current
Interest
Exemption)
(
note
­
alternate
name
in
parentheses)

CAS
Number
Chemical
Name
50­
70­
4
Glucitol,
D­
50­
99­
7
D­
Glucose
57­
50­
1
Sucrose
(
.
alpha.­
D­
Glucopyranoside,
.
beta.­
D­
fructofuranosyl
)
59­
02­
9
2H­
1­
Benzopyran­
6­
ol,
3,4­
dihydro­
2,5,7,8­
tetramethyl­
2­(
4,8,12­
trimethyltridecyl)­,
[
2R­[
2R*(
4R*,
8R*)]]­
69­
65­
8
Mannitol,
D­
124­
38­
9
Carbon
dioxide
142­
47­
2
Glutamic
acid,
monosodium
salt,
L­
1592­
23­
0
Stearic
acid,
calcium
salt
(
Octadecanoic
acid,
calcium
salt
)
7440­
44­
0
Carbon
8001­
21­
6
Sunflower
oil
8001­
22­
7
Soybean
oil
8001­
26­
1
Linseed
oil
8001­
29­
4
Cottonseed
oil
8001­
30­
7
Corn
oil
8001­
31­
8
Coconut
oil
8001­
78­
3
Castor
oil,
hydrogenated
8001­
79­
4
Castor
oil
8002­
03­
7
Peanut
oil
8002­
75­
3
Palm
oil
8006­
54­
0
Lanolin
8016­
28­
2
Lard
oil
8016­
70­
4
Soybean
oil,
hydrogenated
8021­
99­
6
Charcoal,
bone
8029­
43­
4
Syrups,
hydrolyzed
starch
9050­
36­
6
Maltodextrin
16291­
96­
6
Charcoal
61789­
97­
7
Tallow
61789­
99­
9
Lard
64147­
40­
6
Castor
oil,
dehydrated
64755­
01­
7
Fatty
acids,
tallow,
calcium
salts
65996­
63­
6
Starch,
acid­
hydrolyzed
65996­
64­
7
Starch,
enzyme­
hydrolyzed
68188­
81­
8
Grease,
poultry
68334­
00­
9
Cottonseed
oil,
hydrogenated
68334­
28­
1
Fats
and
Glyceridic
oils,
vegetable,
hydrogenated
68409­
76­
7
Bone
meal,
steamed
68425­
17­
2
Syrups,
hydrolyzed
starch,
hydrogenated
68439­
86­
1
Bone,
ash
68476­
78­
8
Molasses
68514­
27­
2
Grease,
catch
basin
68514­
74­
9
Palm
oil,
hydrogenated
68525­
87­
1
Corn
oil,
hydrogenated
68918­
42­
3
Soaps,
stocks,
soya
68952­
94­
3
Soaps,
stocks,
vegetable­
oil
68989­
98­
0
Fats
and
Glyceridic
oils,
vegetable,
residues
73138­
67­
7
Lard,
hydrogenated
7
Adjustments
to
the
List
of
Chemical
Substances
that
the
European
Union
(
EU)
Exempted
from
Provisions
of
Its
Existing
Chemicals
Program
Table
3
is
Annex
II
to
the
EU
Council
Regulation
(
EEC)
793/
93
or
the
Existing
Substances
Regulation
(
ESR).
These
chemicals
are
exempt
from
certain
data
reporting
provisions
of
the
ESR.
After
consulting
with
EU
officials
managing
their
Existing
Chemicals
program,
EPA
believes
that
the
EU
made
judgements
similar
in
nature
to
those
used
by
EPA
to
develop
the
list
of
chemical
substances
identified
as
part
of
the
HPV
Challenge
Program
for
which,
based
upon
a
preliminary
review
of
known
hazard
information,
it
was
determined
that
the
SIDS
data
set
would
not
further
our
understanding
of
the
chemical's
properties
(
Table
1
chemicals).
EPA
did
not
have
time
to
evaluate
Table
3
chemicals
in
detail
during
the
EO
12866
interagency
review
period.
In
order
to
promote
the
efficiency
and
effectiveness
of
IURA,
and
in
recognition
of
the
work
completed
by
the
EU,
and
because
a
process
to
revise
the
list
of
low
current
interest
chemicals
not
subject
to
IURA
processing
and
use
information
reporting
has
been
developed,
EPA
believes
the
chemicals
displayed
in
Table
3
should
be
a
starting
point
for
identifying
additional
chemicals
for
the
IURA
partial
exemption.

The
following
adjustments
were
made
to
Table
3.
Table
4
contains
the
resulting
list
of
chemical
substances
from
the
EU
Chemicals
Program
exempted
list
that
are
not
otherwise
sponsored
under
the
HPV
Challenge
Program,
such
that
EPA
has
provisionally
determined
that
the
chemicals
are
of
low
current
interest
chemicals.
EPA
intends
to
confirm
this
determination
prior
to
the
first
IURA
processing
and
use
information
reporting
cycle.

°
Chemicals
from
Table
2
were
removed
from
Table
3
so
that
a
chemical
would
not
be
double
counted
in
the
low
current
interest
partial
exemption.

°
A
number
of
chemicals
sponsored
in
the
HPV
Challenge
or
OECD
SIDS
Program
(
including
the
ICCA
initiative)
were
removed
because
EPA
views
the
sponsorship
of
chemicals
in
the
HPV
Challenge
(
and
the
OECD
SIDS
Program,
including
the
ICCA
initiative)
as
significant
commitments
and
an
indication
of
ongoing
interest
in
the
chemical.
In
addition,
because
these
sponsorships
will
result
in
the
availability
of
complementary
risk
screening
information,
EPA
believes
that
these
should
not
be
considered
low
current
interest
chemicals
for
purposes
of
IURA
processing
and
use
information
reporting.
The
CAS
numbers
of
these
chemicals
are:
57­
10­
3,
57­
11­
4,
112­
80­
1,
143­
07­
7,
143­
18­
0,
527­
07­
1,
822­
16­
2,
1338­
43­
8,
8030­
12­
4,
61788­
59­
8,
61788­
61­
2,
61790­
37­
2,
67701­
03­
5,
67701­
05­
7,
67701­
06­
8,
67701­
08­
0,
67701­
30­
8,
67762­
26­
9,
67762­
36­
1,68308­
53­
2,
and
68424­
37­
3.

°
Chemicals
that
are
not
on
the
TSCA
Inventory
of
Chemical
Substances
were
removed
from
Table
3.
Premanufacture
Notices
under
TSCA
Section
5
will
need
to
be
submitted
to
EPA
before
they
can
be
manufactured
in
or
imported
to
the
United
States.
The
CAS
numbers
of
these
chemicals
were:
85665­
33­
4,
90990­
10­
6,
90990­
15­
1,
and
93165­
31­
2.
°
Chemicals
that
are
included
in
an
exemption
or
partial
exemption
under
the
IURA
were
removed
from
Table
3.
CAS
number
7732­
18­
5
is
included
in
the
petroleum
streams
partial
exemption.
8
Table
3
9
10
11
Table
4
Chemicals
from
the
EU
Chemicals
Program
Exempted
List
That
Are
Not
Otherwise
Sponsored
Under
the
HPV
Challenge
Program
(
Included
in
the
Initial
IURA
Low
Current
Interest
Exemption)*
(
note
­
alternate
name
in
parentheses)

CAS
Number
Chemical
Name
50­
81­
7
ascorbic
acid
(
L­
Ascorbic
acid)
56­
87­
1
L­
lysine
58­
95­
7
a­
cocphenyl
acetate
(
2H­
1­
Benzopyran­
6­
ol,
3,4­
dihydro­
2,5,7,8­
tetramethyl­
2­[(
4R,
8R)­
4,8,12­
trimethyltridecyl]­,
acetate,
(
2R)­
)
59­
51­
8
DL­
methionine
87­
79­
6
l­
Sorbose
123­
94­
4
glycerol
stearate,
pure
(
Octadecanoic
acid,
2,3­
dihydroxypropyl
ester
)
137­
08­
6
calcium
pantothenate,
D­
form
(
.
beta.­
Alanine,
N­[(
2R)­
2,4­
dihydroxy­
3,3­
dimethyl­
1­
oxobutyl]­,
calcium
alt
(
2:
1)
)
150­
30­
1
DL­
phenylalanine
1317­
65­
3
Limestone
7440­
37­
1
Argon
7727­
37­
9
Nitrogen
7732­
18­
5
Water,
distilled,
conductivity
or
of
similar
purity
7782­
42­
5
graphite
8001­
23­
8
Safflower
oil
8002­
13­
9
Rape
oil
8002­
43­
5
Lecithins
9004­
53­
9
Dextrin
9005­
25­
8
Starch
11103­
57­
4
Vitamin
A
26836­
47­
5
D­
glucitol
monostearate
(
D­
Glucitol,
monooctadecanoate
)
61789­
44­
4
fatty
acids,
castor
oil
67701­
01­
3
fatty
acids,
C12
­
18
68002­
85­
7
fatty
acids,
C14­
22
and
C16­
22
unsatd.
68131­
37­
3
syrups,
corn,
dehydrated
(
Syrups,
hydrolyzed
starch,
dehydrated
)
68308­
54­
3
glycerides,
tallow
mono­,
di­
and
tri­,
hydrogenated
68424­
45­
3
fatty
acids,
linseed
oil
68424­
61­
3
glycerides,
C16­
18
and
C18unsatd.
mono­
and
di­

*
Note
­
CAS
No.
7732­
18­
5
is
NOT
included
in
the
initial
low
current
interest
partial
exemption
list
due
to
the
fact
that
it
is
already
included
in
the
petroleum
process
streams
partial
exemption.
12
Chemicals
otherwise
identified
by
EPA
for
inclusion
in
the
initial
IURA
low
current
interest
exemption
based
on
consideration
of
the
chemical's
structure,
properties,
existing
hazard
information,
and
available
information
concerning
the
extent
of
exposure,
and
which
are
not
currently
a
part
of
another
Agency
program
such
as
the
HPV
Challenge
Program
During
the
E.
O.
12866
interagency
review,
EPA
was
able
to
quickly
determine,
based
on
a
review
of
their
chemical
structures,
properties,
existing
hazard
information,
and
available
exposure
information,
that
IURA
processing
and
use
information
is
of
low
current
interest
for
certain
other
chemicals.
These
chemicals
were:

1333­
74­
0
hydrogen
7782­
44­
7
oxygen
and
several
alkyl
benzenes
listed
below
for
which
EPA
has
received
detailed
exposure
information
from
manufacturers
and
which
had
been
screened
in
the
OECD
HPV
SIDS
Program.

68442­
69­
3
benzene,
mono­
C10­
14­
alkyl
derivs.
68648­
86­
2
benzene,
C14­
16­
alkyl
derivs.
68648­
87­
3
benzene,
C10­
16­
alkyl
derivs.
129813­
58­
7
benzene,
mono­
C10­
13­
alkyl
derivs
129813­
59­
8
benzene,
mono­
C12­
14­
alkyl
derivs.
129813­
60­
1
benzene,
mono­
C14­
16­
alkyl
derivs.

EPA
believes
that
there
is
little
likelihood
that
these
chemicals
will
need
to
be
evaluated
again
in
the
near
future
and
that
IURA
processing
and
use
information
is
of
low
current
interest.
EPA
will
endeavor
to
identify
additional
chemicals
that
can
be
determined
to
be
of
low
current
interest
and
will
so
revise
the
list
of
chemicals
exempt
from
IURA
processing
and
use
information
reporting
requirements.