Document ID: EPA-HQ-OPP-2011-0985-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2012-11-14T05:00Z

\* MERGEFORMAT
                 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                            WASHINGTON, D.C.  20460

                                                      OFFICE OF CHEMICAL SAFETY
                                                     	AND POLLUTION PREVENTION 
MEMORANDUM

DATE:  	September 27, 2012   

SUBJECT:	Revised Flonicamid Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessments for an IR-4 Section 3 Registration Action on Berry Low-Growing Subgroup 13-07G, Cucumber for Greenhouse Use Only, and Rapeseed Sub-group 20A.   

PC Code:  128016
DP Barcode:  D397279
Decision No.: 457726
Registration Nos.:  71512-9, 71512-10
Petition No.:  1E7942
Regulatory Action:  Section 3 Registration
Assessment Type: Single Chemical
Case No.:  NA
TXR No.:  NA
CAS No.:  158062-67-0
MRID No.:  NA
40 CFR:  §180.613

REVIEWER:	Cassi L. Walls, Ph.D., Senior Biologist 
            Risk Assessment Branch III
            Health Effects Division (7509P)
            
THROUGH:   Julie Van Alstine, MPH, Environmental Health Scientist
	Amelia M. Acierto, Chemist 
	Dietary Exposure Science Advisory Council (DESAC)
            Health Effects Division (7509P)

            Jeff Dawson, Acting Branch Chief
            Risk Assessment Branch III
            Health Effects Division (7509P)
            
TO:	Barry O'Keefe, Risk Assessor
            Risk Assessment Branch III
            Health Effects Division (7509P)

Executive Summary

Chronic aggregate dietary (food and drinking water) exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) Version 3.16, which uses food consumption data from the U.S. Department of Agriculture's National Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA).  This dietary survey was conducted from 2003 to 2008.  The analysis was performed to support a petition for tolerances in conjunction with an IR-4 petition for a Section 3 registration for the new uses of flonicamid on berry low-growing subgroup 13-07G, cucumber (for greenhouse use only), and rapeseed sub-group 20A.

Chronic Dietary Exposure Results and Characterization

Tolerance-level residues combined with 100% crop treated were used to determine the chronic dietary exposure and risk estimates.  Drinking water was incorporated directly into the dietary assessment.  The chronic dietary exposure estimates for food and drinking water are below HED's level of concern for the general U.S. population [11% of the chronic population adjusted dose (cPAD)] and the most highly exposed population subgroup, children 1  -  2 years old (28% of the cPAD).  

Acute Dietary Exposure Results and Characterization

An acute dietary risk assessment was not performed as flonicamid has no acute toxicological endpoint.

Cancer Dietary Exposure Results and Characterization

A cancer dietary assessment was not conducted as flonicamid has been determined to be "Suggestive Evidence of Carcinogenicity, but Not Sufficient to Assess Human Carcinogenic Potential".

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the population adjusted dose (PAD).  The PAD is equivalent to point of departure (POD) (e.g., NOAEL, LOAEL) divided by the required uncertainty or safety factors.

For non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  HED is generally concerned when estimated cancer risk exceeds one in one million. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  "Available Information on Assessing Exposure from Pesticides, A User's Guide," 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for flonicamid was conducted by Amelia Acierto 
(08-NOV-2007, DP Number 343466).

II.	Residue Information    
 

Flonicamid Use:

Flonicamid is a Group 9C insecticide (selective feeding blocker) registered for the control of a variety of aphid pests and the suppression of a variety of non-aphid pests.  Tolerances for registered commodities can be found in 40 CFR§180.613.  The tolerances that are currently being recommended are listed in Table 1, below.  The residues of concern in/on plants are the parent flonicamid and its major metabolites, TFNA-AM, TFNA, and TFNG; and in/on ruminants are the parent and its metabolites TFNA-AM and TFNA. 

Residue Data used for Chronic Assessments:

The residue levels used in the chronic assessment were the tolerance levels for plant commodities established under 40 CFR §180.613 and the HED recommended tolerance levels based on the crop field trials for the proposed crops.  The livestock commodity tolerances are unchanged from the previous assessment.  Table 1 presents a summary of the tolerance residue levels used in the chronic assessment. 

Estimated concentrations of flonicamid in drinking water from the proposed uses were provided by EFED and incorporated directly into the chronic assessment.  

The assessments used 100% crop treated.

Table 1.  Tolerance Summary for Proposed Uses of Flonicamid
Commodity
                              Proposed Tolerance 
                                     (ppm)
                          HED Recommended Tolerance 
                                     (ppm)
Comments 
(correct commodity definition)
Berry, low growing, subgroup 13-07G
                                      1.4
                                      1.5

Rapeseed subgroup 20A
                                      1.5
                                      1.5

Vegetable, cucurbit, group 9
                                      0.4
                                      1.5
Vegetable, cucurbit, group 9

Processing Factors:

Separate tolerances were established for dried potatoes, tomato paste, and tomato puree based on processing studies.  The processing factor was set to 1.0 for these commodities.  DEEM default processing factors were used for the other processed commodities for which default processing factors are available. 

III.  Drinking Water

The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED) in the following memorandum: "Drinking Water Assessment to Assess Flonicamid Use on Low Growing Berries Subgroup 13-07G, Greenhouse Cucumbers, and Rapeseed 20A" (J. Hetrick, D396906, 4/25/12).  Water residues were incorporated in the DEEM-FCID into the food categories "water, direct, all sources" and "water, indirect, all sources." 

No monitoring data of flonicamid were available to EFED.  The estimated drinking water concentrations from surface water sources were calculated using the Tier II PRZM (Pesticide Root Zone Model) and EXAMS (Exposure Analysis Modeling System).  PRZM is used to simulate pesticide transport as a result of runoff and erosion from an agricultural field and EXAMS estimates environmental fate and transport of pesticides in surface water.  The values generated by the models for drinking water were multiplied by a national crop area factor (PCA), which accounts for the fact that it is unlikely for any basin to be completely planted to agricultural crops.  Ground water concentrations were estimated using the Tier I SCI-GROW Model.  The model and its description are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/.  Flonicamid may be applied by aerial, ground, or chemigation as per the labels for this product.   This memo only addresses the estimations of parent flonicamid and its major metabolites, TFNG, TFNA, TFNA-OH, TFNA-AM, and TFNG-AM.  

Based on modeling results, the estimated concentration of flonicamid and its degradation products is 1.9 ug /L (ppb) for the 1 in 10 year annual mean concentration (non-cancer chronic). This estimate is based on three aerial applications at the rate of 0.089 lb ai/acre to potatoes in Maine using a PCA factor of 0.87.

Both the acute and chronic estimated concentrations for flonicamid in ground water using the SCIGROW (version 2.3) Model are 1.32 x 10[-3] ug/L (ppb) for the combined residues. 

The surface water value of 1.9 ppb was used in the dietary assessment because the surface water estimate is greater than the ground water estimate.

IV.	DEEM-FCID(TM) Program and Consumption Information

Flonicamid chronic dietary exposure assessment was conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM-FCID, Version 3.16, which incorporates consumption data from USDA's NHANES/WWEIA.  This dietary survey was conducted from 2003 to 2008.  The data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods "as consumed" (e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events.  Based on analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

V.	Toxicological Information

The toxicity database for flonicamid was evaluated by HED's Toxicology Team on 9/30/2004.  The team selected endpoints and evaluated for FQPA concerns based on the potential hazard and exposure data for flonicamid and determined that there was no need for an additional safety factor for the protection of infants and children.  Flonicamid is classified to be category "Suggestive Evidence of Carcinogenicity, but Not Sufficient to Assess Human Carcinogenic Potential," according to the EPA Draft Guidelines for Carcinogen Risk Assessment dated July, 1999; therefore, a cancer assessment is not necessary.  HED's current toxicology team has reevaluated the endpoints and determined they are acceptable and applicable for risk assessment purposes.

Table 2.  Summary of Dose and Toxicological Endpoint Selection Relative to Use in Dietary Human Health Risk Assessment for Flonicamid

Exposure
Scenario

Dose (mg/kg/day) 
UF

FQPA Safety Factor and Level of Concern for Risk Assessment

Endpoint for Risk Assessment

Acute Dietary
general population including infants and children

N/A

N/A

N/A

Chronic Dietary
(All populations)

NOAEL= 4.0 mg/kg/day  
UF = 100 
cPAD = 0.04 mg/kg/day

FQPA SF = 1x

cPAD = Chronic RfD 
               FQPA SF
           = 0.04 mg/kg/day

2-Gen reproduction study in the rat.  Parental LOAEL = 22 mg/kg/day based on increased kidney weights, kidney hyaline deposition, increased blood serum LH (F1 females). 

Cancer (oral, dermal, inhalation)

Classified as "Suggestive Evidence of Carcinogenicity, but Not Sufficient to Assess Human Carcinogenic Potential"

N/A

N/A
UF = uncertainty factor, FQPA SF = Special FQPA safety factor, NOEL = no observed adverse effect level, LOAEL = lowest observed adverse effect level, cPAD = chronic population, adjusted dose, Rfd = reference dose, N/A = not applicable.
VI.	Results/Discussion

As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID(TM) analyses estimate the dietary exposure of the U.S. population and various population subgroups.  The results reported in Table 3 below are for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years.  

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis					

The results of the chronic dietary (food and drinking water) exposure analysis are reported in Table 3 below.      

The chronic dietary (food and drinking water) exposure to flonicamid is below HED's level of concern for the general U.S. population and all population subgroups.  The chronic dietary exposure estimates are 11% cPAD for the general U.S. population and 25% cPAD for children 1-2 years old, the most highly exposed population subgroup.

Table 3.   Summary of Dietary (Food and Drinking Water) Exposure and Risk for Flonicamid[1]

                                       
                              Population Subgroup

                               cPAD (mg/kg/day)

                             Exposure (mg/kg/day)

                                    % cPAD
                                       
                                       

                                   DEEM-FCID

                                   DEEM-FCID

General U.S. Population
                                       
                                     0.04

                           0.004455                
                                      11

All Infants (< 1 year old)
                                       

                           0.006272                
                                      16

Children 1-2 years old
                                       

                           0.011236                
                                      28

Children 3-5 years old
                                       

                           0.008413                
                                      21

Children 6-12 years old
                                       

                           0.004999                
                                      11

Youth 13-19 years old
                                       

                           0.003184                 
                                       8

Adults 20-49 years old
                                       

                           0.003864                 
                                      10

Females 13-49 years old
                                       

                           0.003962                 
                                      10

Adults 50-99 years old
                                       

                           0.004270                
                                      11
1 The population with the highest exposure is in bold

VII.	Characterization of Inputs/Outputs

The chronic dietary exposure analysis is considered to be conservative.  As a result, HED is confident that exposure is not underestimated to the U.S. population or any population subgroup.  Further refinements could be made; however, they are not necessary at the present time.

VIII.	 Conclusions

The chronic dietary exposure assessment was conducted for the proposed uses on greenhouse cucumber, low growing berries, rapeseed, and drinking water.  A conservative assessment was conducted using tolerance residue values and 100% crop treated.  Estimated concentrations of flonicamid in drinking water from the proposed uses were provided by EFED and incorporated directly into the chronic assessments.  

The chronic dietary (food and drinking water) exposure to flonicamid is below HED's level of concern for the general U.S. population and all population subgroups.  The chronic dietary exposure estimates are 11% cPAD for the general U.S. population and 28% cPAD for children 1-2 years old, the most highly exposed population subgroup.

IX.		List of Attachments

 Attachment 1: Chronic Food and Water Residue Input File.
 Attachment 2: Chronic Results File.
                                                                              

             Attachment 1.  DEEM-FCID Chronic Residue Input File.
                                       
Filename: C:\Documents and Settings\cwalls\My Documents\Cassi\HED\Flonicamid\FLONICAMID050712.R08
Chemical: FLONICAMID
RfD(Chronic): .04 mg/kg bw/day  NOEL(Chronic): 4 mg/kg bw/day
RfD(Acute): 0 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day
Date created/last modified: 08-23-2012/09:49:14       Program ver. 3.16, 03-08-d
Comment: CHRONIC ONLY
-----------------------------------------------------------------------------------
   EPA     Crop                                   Def Res     Adj.Factors   Comment
   Code     Grp  Commodity Name                    (ppm)       #1    #2   
---------- ---- -------------------------------  ----------  ------ ------  -------
0101050000 1AB  Beet, garden, roots                0.600000   1.000  1.000  
0101050001 1AB  Beet, garden, roots-babyfood       0.600000   1.000  1.000  
0101067000 1AB  Burdock                            0.600000   1.000  1.000  
0101078000 1AB  Carrot                             0.600000   1.000  1.000  
0101078001 1AB  Carrot-babyfood                    0.600000   1.000  1.000  
0101079000 1AB  Carrot, juice                      0.600000   1.000  1.000  
0101084000 1AB  Celeriac                           0.600000   1.000  1.000  
0101100000 1AB  Chicory, roots                     0.600000   1.000  1.000  
0101168000 1AB  Ginseng, dried                     0.600000   1.000  1.000  
0101190000 1AB  Horseradish                        0.600000   1.000  1.000  
0101250000 1AB  Parsley, turnip rooted             0.600000   1.000  1.000  
0101251000 1AB  Parsnip                            0.600000   1.000  1.000  
0101251001 1AB  Parsnip-babyfood                   0.600000   1.000  1.000  
0101314000 1AB  Radish, roots                      0.600000   1.000  1.000  
0101316000 1AB  Radish, Oriental, roots            0.600000   1.000  1.000  
0101327000 1AB  Rutabaga                           0.600000   1.000  1.000  
0101331000 1AB  Salsify, roots                     0.600000   1.000  1.000  
0101388000 1AB  Turnip, roots                      0.600000   1.000  1.000  
0103015000 1CD  Arrowroot, flour                   0.200000   1.000  1.000  
0103015001 1CD  Arrowroot, flour-babyfood          0.200000   1.000  1.000  
0103017000 1CD  Artichoke, Jerusalem               0.200000   1.000  1.000  
0103082000 1CD  Cassava                            0.200000   1.000  1.000  
0103082001 1CD  Cassava-babyfood                   0.200000   1.000  1.000  
0103139000 1CD  Dasheen, corm                      0.200000   1.000  1.000  
0103166000 1CD  Ginger                             0.200000   1.000  1.000  
0103166001 1CD  Ginger-babyfood                    0.200000   1.000  1.000  
0103167000 1CD  Ginger, dried                      0.200000   1.000  1.000  
0103296000 1C   Potato, chips                      0.200000   1.000  1.000  
0103297000 1C   Potato, dry (granules/ flakes)     0.400000   1.000  1.000  
0103297001 1C   Potato, dry (granules/ flakes)-b   0.400000   1.000  1.000  
0103298000 1C   Potato, flour                      0.400000   1.000  1.000  
0103298001 1C   Potato, flour-babyfood             0.400000   1.000  1.000  
0103299000 1C   Potato, tuber, w/peel              0.200000   1.000  1.000  
0103299001 1C   Potato, tuber, w/peel-babyfood     0.200000   1.000  1.000  
0103300000 1C   Potato, tuber, w/o peel            0.200000   1.000  1.000  
0103300001 1C   Potato, tuber, w/o peel-babyfood   0.200000   1.000  1.000  
0103366000 1CD  Sweet potato                       0.200000   1.000  1.000  
0103366001 1CD  Sweet potato-babyfood              0.200000   1.000  1.000  
0103371000 1CD  Tanier, corm                       0.200000   1.000  1.000  
0103387000 1CD  Turmeric                           0.200000   1.000  1.000  
0103406000 1CD  Yam, true                          0.200000   1.000  1.000  
0103407000 1CD  Yam bean                           0.200000   1.000  1.000  
0200315000 2    Radish, tops                      16.000000   1.000  1.000  
0401005000 4A   Amaranth, leafy                    4.000000   1.000  1.000  
0401018000 4A   Arugula                            4.000000   1.000  1.000  
0401104000 4A   Chrysanthemum, garland             4.000000   1.000  1.000  
0401133000 4A   Cress, garden                      4.000000   1.000  1.000  
0401134000 4A   Cress, upland                      4.000000   1.000  1.000  
0401138000 4A   Dandelion, leaves                  4.000000   1.000  1.000  
0401150000 4A   Endive                             4.000000   1.000  1.000  
0401204000 4A   Lettuce, head                      4.000000   1.000  1.000  
0401205000 4A   Lettuce, leaf                      4.000000   1.000  1.000  
0401248000 4A   Parsley, leaves                    4.000000   1.000  1.000  
0401313000 4A   Radicchio                          4.000000   1.000  1.000  
0401355000 4A   Spinach                            9.000000   1.000  1.000  
0401355001 4A   Spinach-babyfood                   9.000000   1.000  1.000  
0402076000 4B   Cardoon                            4.000000   1.000  1.000  
0402085000 4B   Celery                             4.000000   1.000  1.000  
0402085001 4B   Celery-babyfood                    4.000000   1.000  1.000  
0402086000 4B   Celery, juice                      4.000000   1.000  1.000  
0402087000 4B   Celtuce                            4.000000   1.000  1.000  
0402152000 4B   Fennel, Florence                   4.000000   1.000  1.000  
0402322000 4B   Rhubarb                            4.000000   1.000  1.000  
0402367000 4B   Swiss chard                        4.000000   1.000  1.000  
0501061000 5A   Broccoli                           1.500000   1.000  1.000  
0501061001 5A   Broccoli-babyfood                  1.500000   1.000  1.000  
0501062000 5A   Broccoli, Chinese                  1.500000   1.000  1.000  
0501064000 5A   Brussels sprouts                   1.500000   1.000  1.000  
0501069000 5A   Cabbage                            1.500000   1.000  1.000  
0501071000 5A   Cabbage, Chinese, napa             1.500000   1.000  1.000  
0501072000 5A   Cabbage, Chinese, mustard          1.500000   1.000  1.000  
0501083000 5A   Cauliflower                        1.500000   1.000  1.000  
0501196000 5A   Kohlrabi                           1.500000   1.000  1.000  
0502063000 5B   Broccoli raab                     16.000000   1.000  1.000  
0502070000 5B   Cabbage, Chinese, bok choy        16.000000   1.000  1.000  
0502117000 5B   Collards                          16.000000   1.000  1.000  
0502194000 5B   Kale                              16.000000   1.000  1.000  
0502229000 5B   Mustard greens                    16.000000   1.000  1.000  
0502318000 5B   Rape greens                       16.000000   1.000  1.000  
0502389000 5B   Turnip, greens                    16.000000   1.000  1.000  
0801374000 8A   Tomatillo                          0.400000   1.000  1.000  
0801375000 8A   Tomato                             0.400000   1.000  1.000  
0801375001 8A   Tomato-babyfood                    0.400000   1.000  1.000  
0801376000 8A   Tomato, paste                      2.000000   1.000  1.000  
0801376001 8A   Tomato, paste-babyfood             2.000000   1.000  1.000  
0801377000 8A   Tomato, puree                      0.500000   1.000  1.000  
0801377001 8A   Tomato, puree-babyfood             0.500000   1.000  1.000  
0801378000 8A   Tomato, dried                      0.400000  14.300  1.000  
0801378001 8A   Tomato, dried-babyfood             0.400000  14.300  1.000  
0801379000 8A   Tomato, juice                      0.400000   1.500  1.000  
0802148000 8BC  Eggplant                           0.400000   1.000  1.000  
0802234000 8BC  Okra                               0.400000   1.000  1.000  
0802270000 8B   Pepper, bell                       0.400000   1.000  1.000  
0802270001 8B   Pepper, bell-babyfood              0.400000   1.000  1.000  
0802271000 8B   Pepper, bell, dried                0.400000   1.000  1.000  
0802271001 8B   Pepper, bell, dried-babyfood       0.400000   1.000  1.000  
0802272000 8BC  Pepper, nonbell                    0.400000   1.000  1.000  
0802272001 8BC  Pepper, nonbell-babyfood           0.400000   1.000  1.000  
0802273000 8BC  Pepper, nonbell, dried             0.400000   1.000  1.000  
0901075000 9A   Cantaloupe                         1.500000   1.000  1.000  
0901187000 9A   Honeydew melon                     1.500000   1.000  1.000  
0901399000 9A   Watermelon                         1.500000   1.000  1.000  
0901400000 9A   Watermelon, juice                  1.500000   1.000  1.000  
0902021000 9B   Balsam pear                        1.500000   1.000  1.000  
0902088000 9B   Chayote, fruit                     1.500000   1.000  1.000  
0902102000 9B   Chinese waxgourd                   1.500000   1.000  1.000  
0902135000 9B   Cucumber                           1.500000   1.000  1.000  
0902308000 9B   Pumpkin                            1.500000   1.000  1.000  
0902309000 9B   Pumpkin, seed                      1.500000   1.000  1.000  
0902356000 9B   Squash, summer                     1.500000   1.000  1.000  
0902356001 9B   Squash, summer-babyfood            1.500000   1.000  1.000  
0902357000 9B   Squash, winter                     1.500000   1.000  1.000  
0902357001 9B   Squash, winter-babyfood            1.500000   1.000  1.000  
1100007000 11   Apple, fruit with peel             0.200000   1.000  1.000  
1100008000 11   Apple, peeled fruit                0.200000   1.000  1.000  
1100008001 11   Apple, peeled fruit-babyfood       0.200000   1.000  1.000  
1100009000 11   Apple, dried                       0.200000   8.000  1.000  
1100009001 11   Apple, dried-babyfood              0.200000   8.000  1.000  
1100010000 11   Apple, juice                       0.200000   1.300  1.000  
1100010001 11   Apple, juice-babyfood              0.200000   1.300  1.000  
1100011000 11   Apple, sauce                       0.200000   1.000  1.000  
1100011001 11   Apple, sauce-babyfood              0.200000   1.000  1.000  
1100129000 11   Crabapple                          0.200000   1.000  1.000  
1100210000 11   Loquat                             0.200000   1.000  1.000  
1100266000 11   Pear                               0.200000   1.000  1.000  
1100266001 11   Pear-babyfood                      0.200000   1.000  1.000  
1100267000 11   Pear, dried                        0.200000   6.250  1.000  
1100268000 11   Pear, juice                        0.200000   1.000  1.000  
1100268001 11   Pear, juice-babyfood               0.200000   1.000  1.000  
1100310000 11   Quince                             0.200000   1.000  1.000  
1201090000 12A  Cherry                             0.600000   1.000  1.000  
1201090001 12A  Cherry-babyfood                    0.600000   1.000  1.000  
1201091000 12A  Cherry, juice                      0.600000   1.500  1.000  
1201091001 12A  Cherry, juice-babyfood             0.600000   1.500  1.000  
1202012000 12B  Apricot                            0.600000   1.000  1.000  
1202012001 12B  Apricot-babyfood                   0.600000   1.000  1.000  
1202013000 12B  Apricot, dried                     0.600000   6.000  1.000  
1202014000 12B  Apricot, juice                     0.600000   1.000  1.000  
1202014001 12B  Apricot, juice-babyfood            0.600000   1.000  1.000  
1202230000 12B  Nectarine                          0.600000   1.000  1.000  
1202260000 12B  Peach                              0.600000   1.000  1.000  
1202260001 12B  Peach-babyfood                     0.600000   1.000  1.000  
1202261000 12B  Peach, dried                       0.600000   7.000  1.000  
1202261001 12B  Peach, dried-babyfood              0.600000   7.000  1.000  
1202262000 12B  Peach, juice                       0.600000   1.000  1.000  
1202262001 12B  Peach, juice-babyfood              0.600000   1.000  1.000  
1203285000 12C  Plum                               0.600000   1.000  1.000  
1203285001 12C  Plum-babyfood                      0.600000   1.000  1.000  
1203286000 12C  Plum, prune, fresh                 0.600000   1.000  1.000  
1203286001 12C  Plum, prune, fresh-babyfood        0.600000   1.000  1.000  
1203287000 12C  Plum, prune, dried                 0.600000   5.000  1.000  
1203287001 12C  Plum, prune, dried-babyfood        0.600000   5.000  1.000  
1203288000 12C  Plum, prune, juice                 0.600000   1.400  1.000  
1203288001 12C  Plum, prune, juice-babyfood        0.600000   1.400  1.000  
1307130000 13G  Cranberry                          1.500000   1.000  1.000  
1307130001 13G  Cranberry-babyfood                 1.500000   1.000  1.000  
1307131000 13G  Cranberry, dried                   1.500000   1.000  1.000  
1307132000 13G  Cranberry, juice                   1.500000   1.100  1.000  
1307132001 13G  Cranberry, juice-babyfood          1.500000   1.100  1.000  
1307359000 13G  Strawberry                         1.500000   1.000  1.000  
1307359001 13G  Strawberry-babyfood                1.500000   1.000  1.000  
1307360000 13G  Strawberry, juice                  1.500000   1.000  1.000  
1307360001 13G  Strawberry, juice-babyfood         1.500000   1.000  1.000  
2001163000 20A  Flax seed, oil                     1.500000   1.000  1.000  
2001319000 20A  Rapeseed, oil                      1.500000   1.000  1.000  
2001319001 20A  Rapeseed, oil-babyfood             1.500000   1.000  1.000  
2001336000 20A  Sesame, seed                       1.500000   1.000  1.000  
2001336001 20A  Sesame, seed-babyfood              1.500000   1.000  1.000  
2001337000 20A  Sesame, oil                        1.500000   1.000  1.000  
2001337001 20A  Sesame, oil-babyfood               1.500000   1.000  1.000  
2003128000 20C  Cottonseed, oil                    0.500000   1.000  1.000  
2003128001 20C  Cottonseed, oil-babyfood           0.500000   1.000  1.000  
3100044000 31   Beef, meat                         0.080000   1.000  1.000  
3100044001 31   Beef, meat-babyfood                0.080000   1.000  1.000  
3100045000 31   Beef, meat, dried                  0.080000   1.920  1.000  
3100046000 31   Beef, meat byproducts              0.080000   1.000  1.000  
3100046001 31   Beef, meat byproducts-babyfood     0.080000   1.000  1.000  
3100047000 31   Beef, fat                          0.030000   1.000  1.000  
3100047001 31   Beef, fat-babyfood                 0.030000   1.000  1.000  
3100048000 31   Beef, kidney                       0.080000   1.000  1.000  
3100049000 31   Beef, liver                        0.080000   1.000  1.000  
3100049001 31   Beef, liver-babyfood               0.080000   1.000  1.000  
3200169000 32   Goat, meat                         0.080000   1.000  1.000  
3200170000 32   Goat, meat byproducts              0.080000   1.000  1.000  
3200171000 32   Goat, fat                          0.030000   1.000  1.000  
3200172000 32   Goat, kidney                       0.080000   1.000  1.000  
3200173000 32   Goat, liver                        0.080000   1.000  1.000  
3300189000 33   Horse, meat                        0.080000   1.000  1.000  
3500339000 35   Sheep, meat                        0.080000   1.000  1.000  
3500339001 35   Sheep, meat-babyfood               0.080000   1.000  1.000  
3500340000 35   Sheep, meat byproducts             0.080000   1.000  1.000  
3500341000 35   Sheep, fat                         0.030000   1.000  1.000  
3500341001 35   Sheep, fat-babyfood                0.030000   1.000  1.000  
3500342000 35   Sheep, kidney                      0.080000   1.000  1.000  
3500343000 35   Sheep, liver                       0.080000   1.000  1.000  
3600222000 36   Milk, fat                          0.030000   1.000  1.000  
3600222001 36   Milk, fat-baby food/infant formu   0.030000   1.000  1.000  
3600223000 36   Milk, nonfat solids                0.030000   1.000  1.000  
3600223001 36   Milk, nonfat solids-baby food/in   0.030000   1.000  1.000  
3600224000 36   Milk, water                        0.030000   1.000  1.000  
3600224001 36   Milk, water-babyfood/infant form   0.030000   1.000  1.000  
3600225001 36   Milk, sugar (lactose)-baby food/   0.030000   1.000  1.000  
4000093000 40   Chicken, meat                      0.030000   1.000  1.000  
4000093001 40   Chicken, meat-babyfood             0.030000   1.000  1.000  
4000094000 40   Chicken, liver                     0.030000   1.000  1.000  
4000095000 40   Chicken, meat byproducts           0.030000   1.000  1.000  
4000095001 40   Chicken, meat byproducts-babyfoo   0.030000   1.000  1.000  
4000096000 40   Chicken, fat                       0.030000   1.000  1.000  
4000096001 40   Chicken, fat-babyfood              0.030000   1.000  1.000  
4000097000 40   Chicken, skin                      0.030000   1.000  1.000  
4000097001 40   Chicken, skin-babyfood             0.030000   1.000  1.000  
5000382000 50   Turkey, meat                       0.030000   1.000  1.000  
5000382001 50   Turkey, meat-babyfood              0.030000   1.000  1.000  
5000383000 50   Turkey, liver                      0.030000   1.000  1.000  
5000383001 50   Turkey, liver-babyfood             0.030000   1.000  1.000  
5000384000 50   Turkey, meat byproducts            0.030000   1.000  1.000  
5000384001 50   Turkey, meat byproducts-babyfood   0.030000   1.000  1.000  
5000385000 50   Turkey, fat                        0.030000   1.000  1.000  
5000385001 50   Turkey, fat-babyfood               0.030000   1.000  1.000  
5000386000 50   Turkey, skin                       0.030000   1.000  1.000  
5000386001 50   Turkey, skin-babyfood              0.030000   1.000  1.000  
6000301000 60   Poultry, other, meat               0.030000   1.000  1.000  
6000302000 60   Poultry, other, liver              0.030000   1.000  1.000  
6000303000 60   Poultry, other, meat byproducts    0.030000   1.000  1.000  
6000304000 60   Poultry, other, fat                0.030000   1.000  1.000  
6000305000 60   Poultry, other, skin               0.030000   1.000  1.000  
7000145000 70   Egg, whole                         0.040000   1.000  1.000  
7000145001 70   Egg, whole-babyfood                0.040000   1.000  1.000  
7000146000 70   Egg, white                         0.040000   1.000  1.000  
7000146001 70   Egg, white (solids)-babyfood       0.040000   1.000  1.000  
7000147000 70   Egg, yolk                          0.040000   1.000  1.000  
7000147001 70   Egg, yolk-babyfood                 0.040000   1.000  1.000  
8601000000 86A  Water, direct, all sources         0.001900   1.000  1.000  
8602000000 86B  Water, indirect, all sources       0.001900   1.000  1.000  
9500188000 O    Hop                                7.000000   1.000  1.000  

                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       
                                       

                   Attachment 2:  DEEM-FCID Chronic Results
                                       
U.S. EPA                                                        Ver. 3.16, 03-08-d
DEEM-FCID Chronic analysis for FLONICAMID                  NHANES 2003-2008 2-day
Residue file name: C:\Documents and Settings\cwalls\My Documents\Cassi\HED\Flonicamid\FLONICAMID050712.R08
                                                 Adjustment factor #2 NOT used.
Analysis Date 09-27-2012/15:13:35     Residue file dated: 09-27-2012/15:12:49
Reference dose (RfD, Chronic) = .04 mg/kg bw/day
COMMENT 1: CHRONIC ONLY
===============================================================================
                    Total exposure by population subgroup
-------------------------------------------------------------------------------

                                                    Total Exposure
                                         -----------------------------------
          Population                         mg/kg             Percent of   
           Subgroup                       body wt/day             Rfd       
--------------------------------------   -------------       ----------------
Total US Population                         0.004455                11.1%
Hispanic                                    0.004094                10.2%
Non-Hisp-White                              0.004421                11.1%
Non-Hisp-Black                              0.004612                11.5%
Non-Hisp-Other                              0.005475                13.7%
Nursing Infants                             0.004389                11.0%
Non-Nursing Infants                         0.007113                17.8%
Female 13+ PREG                             0.004172                10.4%
Children 1-6                                0.009134                22.8%
Children 7-12                               0.004695                11.7%
Male 13-19                                  0.003124                 7.8%
Female 13-19/NP                             0.003246                 8.1%
Male 20+                                    0.003698                 9.2%
Female 20+/NP                               0.004334                10.8%
Seniors 55+                                 0.004270                10.7%
All Infants                                 0.006272                15.7%
Female 13-50                                0.003950                 9.9%
Children 1-2                                0.011236                28.1%
Children 3-5                                0.008413                21.0%
Children 6-12                               0.004999                12.5%
Youth 13-19                                 0.003184                 8.0%
Adults 20-49                                0.003864                 9.7%
Adults 50-99                                0.004270                10.7%
Female 13-49                                0.003962                 9.9%

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