Document ID: EPA-HQ-OPP-2009-0812-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2010-11-17T05:00Z

SEQ CHAPTER \h \r 1 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460      

	OFFICE OF CHEMICAL SAFETY AND

                                                                        
                      POLLUTION PREVENTION

	

MEMORANDUM

Date:  		25-AUG-2010  

SUBJECT:	Acequinocyl.  Chronic Aggregate Dietary (Food and Drinking
Water) Exposure and Risk Assessment for the Section 3 Registration
Action Use on Fruiting Vegetables, Hops, Okra, and Edible-Podded Beans.

PC Code:  006329	DP Barcode:  D369101

Decision No.:  417967	Registration No.:  66330-38

Petition No.:  9E7598	Regulatory Action:  Section 3

Risk Assessment Type:  Dietary	Case No.:  7621

TXR No.:  NA	CAS No.:  57960-19-7

MRID No.:  NA	40 CFR:  §180.599

FROM:	Sarah J. Levy, Chemist

Risk Assessment Branch 1 (RAB1)/Health Effects Division (HED; 7509P)

THROUGH:	Nancy Dodd, Chemist

David Soderberg, Chemist

Dietary Exposure Science Advisory Council (DESAC)/HED (7509P)

and

George F. Kramer, Ph.D., Branch Senior Scientist

Branch/Health Effects Division (7509P)

TO:		Sarah J. Levy, Chemist/Risk Assessor

		RAB1/HED (7509P)

and

Barbara Madden, RM 05

Registration Division (RD; 7505P)

Executive Summary

™, Version 2.03) which use food consumption data from the U.S.
Department of Agriculture’s Continuing Surveys of Food Intakes by
Individuals (CSFII) from 1994-1996 and 1998.  The analysis was performed
to support a requested Section 3 registration use of the insecticide
acequinocyl (2-(acetyloxy)-3-dodecyl-1,4-naphthalenedione) on fruiting
vegetables, hops, okra, and edible-podded beans.  An acute dietary
assessment was not conducted for acequinocyl because an endpoint of
concern attributable to a single dose was not identified; therefore, an
aRfD was not established.  A cancer dietary assessment was not conducted
because acequinocyl was classified as not likely to be carcinogenic to
humans.

   

Chronic Dietary (Food and Drinking Water) Exposure Results and
Characterization

Tolerance-level residues and 100 percent crop treated (%CT) data were
used in the chronic dietary assessment.  DEEM( ver. 7.81 default
processing factors were used with the exception of grape juice and
raisins (see “Residue Information” Section of this document for
details).  For the chronic dietary assessment, the general U.S.
population and all population subgroups have risk estimates which are
not of concern to HED.  The chronic dietary exposure estimate for the
U.S. population is 9.8% of the chronic population-adjusted dose (cPAD). 
The highest exposed population subgroup (children 1-2 years old)
occupies 45% of the cPAD.  The use of anticipated residues (ARs),
empirical processing factors, and %CT would refine further HED’s
exposure and risk estimates; however, refinement is not needed at this
time.

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population-adjusted dose
(PAD).  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL,
e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  HED is generally
concerned when estimated cancer risk exceeds one in one million.
References which discuss the acute and chronic risk assessments in more
detail are available on the EPA/pesticides web site:  “Available
Information on Assessing Exposure from Pesticides, A User’s Guide,”
21-JUN-2000, web link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see
SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for acequinocyl was conducted by
Sarah Levy (11-DEC-2007; DP# 347404).

II.	Residue Information

Under PP#9E7598, the Interregional Research Project No.4 (IR-4), on
behalf of the Agricultural Experiment Stations of AZ, CA, CO, FL, ID,
NC, NJ, NY, OK, OR, TN, TX, VA, and WA, has submitted a petition
proposing the use of acequinocyl (Kanemite( 15 soluble concentrate (SC),
1.25 lb/gal), a quinoline type of miticide, on fruiting vegetables,
hops, okra, and edible-podded beans.  Permanent tolerances are currently
established under 40 CFR §180.599(a) for the combined residues of
acequinocyl and its metabolite, 2-dodecyl-3-hydroxy-1,4-naphthoquinone,
expressed as acequinocyl equivalents, in/on a number of plant and
livestock commodities.  Tolerances for plant commodities range from 0.02
ppm (tree nuts and pistachios) to 30 ppm (citrus oil), and tolerances
for livestock commodities are established at 0.02 ppm in the fat and
liver of cattle, goat, horse, and sheep.  There are residential uses
(greenhouse, ornamental, etc.) for acequinocyl established as well. 
Note that for this petition, there are no livestock feedstuffs
associated with the proposed crop uses; therefore, re-evaluation of the
registered livestock tolerance levels is not necessary at this time.

  SEQ CHAPTER \h \r 1 Based on the structural similarity of
acequinocyl-OH to parent and the presence of acequinocyl-OH at
quantifiable levels in crops, the HED Metabolism Assessment Review
Committee (MARC) concluded that parent and acequinocyl-OH are the
residues of concern for risk assessment and tolerance expression in
apples, oranges, and eggplant commodities (Memo, S. Levy, 07-JAN-2004;
DP# 297872).  For purposes of this petition, HED is willing to translate
these results to hops and edible-podded beans as these two crops are
low-consumption food items.  See Table 1 for a summary of the residues
of concern determined by the MARC.

Table 1.  Residues of Concern in Crops, Ruminants, and Drinking Water.

Matrix	Tolerance Expression	Residues for Risk Assessment

Fruit Crops	Acequinocyl + Acequinocyl-OH (R1)	Acequinocyl +
Acequinocyl-OH (R1)

Ruminants	Acequinocyl + Acequinocyl-OH (R1)	Acequinocyl + Acequinocyl-OH
(R1).  In liver and kidney, also include AKM-15.

Rotational Crops	Not Determined*	Not Determined*

Drinking Water	NA**	Acequinocyl + Acequinocyl-OH (R1)

* A confined rotational crop study has been reviewed and a 30-day
plant-back interval has been recommended (DP#351336, S. Levy, 6/25/08).

** NA = not applicable.

Residue Data used for the Chronic Assessment:

Tolerance-level residues and 100%CT data were used in the chronic
dietary assessment.  DEEM( ver. 7.81 default processing factors were
used with the exception of grape juice and raisins.  As residues were
reduced in both grape juice (<0.02x) and raisin (0.15x), separate
tolerances are not required for these commodities; therefore, the DEEM(
ver. 7.81 default processing factors for juice and raisin were set to 1
as concentration was shown not to occur (Memo, S. Levy, 05-SEP-2007;
DP#: 342805).  The tolerance value of 0.02 ppm for cattle, goat, horse,
and sheep fat and liver was entered for meat byproducts as well, where
applicable.

The use of ARs, empirical processing factors, and %CT data would refine
further HED’s exposure and risk estimates.  However, refinement of the
dietary exposure estimates is not needed at this time.  See Table 2 for
a summary of the data used in the chronic assessment.

Table 2.  Data and Residue Estimates Used in the Acequinocyl Chronic
Dietary Analyses.

Commodity	Data Source

(MRID)	%CT	Processing Factors	HED-Recommended Tolerance (ppm)

Vegetable, fruiting, group 8	47819401,

47819402	

100	NA	0.70

Okra1	Translated

NA	0.70

Bean, edible podded	47819403

NA	0.25

Hop, dried cones	47819404

NA	4.0

1   Okra has been recommended to be added as a member of the fruiting
vegetable group 8; however, until okra has been officially added to the
crop group, a separate tolerance is required for okra at the same
tolerance level (0.70 ppm) as for fruiting vegetables.

III.	Drinking Water Data

The drinking water residues used in the dietary risk assessment were
provided by the Environmental Fate and Effects Division (EFED) (I.
Maher, 29-APR-2010; DP# 368426) and incorporated directly into this
dietary assessment.  Water residues were incorporated directly into
DEEM-FCID under the food categories “water, direct, all sources” and
“water, indirect, all sources.”

Acequinocyl can reach surface water via spray drift and less likely via
runoff.  Due to its high Kd values it is expected to exhibit low
mobility in soil and low potential to leach into groundwater. Once
acequinocyl has entered surface water, it is not likely to persist as it
will hydrolyze to form hydroxy-acequinocyl (also known as OH-AKD 023,
2-hydroxy-3-dodecyl-1,4-napthelenedione (HDNQ), and R-1).

There are no drinking water monitoring data available for acequinocyl or
its metabolite acequinocyl-OH (R1), the residues of concern. 
Groundwater and surface water estimated drinking water concentrations
(EDWCs) were generated for acequinocyl using the Screening Concentration
in Ground Water (SCI-GROW) and Pesticide Root Zone Model/Exposure
Analysis Modeling System (PRZM/EXAMS) models, respectively.  Two
approaches were used in performing the drinking water assessment for the
proposed acequinocyl uses.  In Approach #1, acequinocyl was
conservatively assumed to be stable to all routes of degradation to
account for the uncertainties associated with the environmental fate
data.  In Approach #2, total (acequinocyl + acequinocyl-OH) residues
were modeled with the assumption that the metabolite acequinocyl-OH
(referred to as the R1 degradate in this assessment) is of toxicological
concern.  The highest PRZM-EXAMS surface water modeling estimates were
obtained for the Pennsylvania tomato scenario for the chronic values. 
The modeled EDWCs for ground and surface water are summarized in Table
3.



Table 3.  Ground and Surface Water EDWCs for Acequinocyl.

Approach #1 and #2

Groundwater EDWC for Acequinocyl + R1 (ppb)	Surface Water

	Approach #1

Acequinocyl	Approach #2

Acequinocyl + R1

	1-in-10-Year Chronic Mean Concentration (ppb)	1-in-10-Year Chronic Mean
Concentration (ppb)

0.0036	2.45	0.29

Since the surface water EDWCs are higher than the groundwater EDWC, HED
selected the surface water value for use in the chronic dietary
assessment.  The EDWC derived via Approach #1 represents the upper-bound
value (2.45 ppb) while that derived via Approach #2 represents the
lower-bound value (0.29).  The 2.45 ppb value was used in the dietary
modeling as this value assures a conservative assessment.

™ Program and Consumption Information

An acequinocyl chronic dietary exposure assessment was conducted using
DEEM-FCID™, Version 2.03 which incorporates consumption data from
USDA’s CSFII, 1994-1996 and 1998.  The 1994-96, 98 data are based on
the reported consumption of more than 20,000 individuals over two
non-consecutive survey days.  Foods “as consumed” (e.g., apple pie)
are linked to EPA-defined food commodities (e.g., apples, peeled fruit -
cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S,
baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA.  For chronic exposure assessment,
consumption data are averaged for the entire U.S. population and within
population subgroups, but for acute exposure assessment are retained as
individual consumption events.  Based on analysis of the 1994-96, 98
CSFII consumption data, which took into account dietary patterns and
survey respondents, HED concluded that it is most appropriate to report
risk for the following population subgroups: the general U.S.
population, all infants (<1 year old), children 1-2, children 3-5,
children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+
years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

V.	Toxicological Information

On 14-OCT-2003, the HED Hazard Identification Assessment Review
Committee (HIARC) reviewed the recommendations of the toxicology
reviewer for acequinocyl with regard to the acute and chronic RfDs and
the toxicological endpoint selection for use as appropriate in
occupational/residential exposure risk assessments.  The potential for
increased susceptibility of infants and children from exposure to
acequinocyl was also evaluated as required by the Food Quality
Protection Act (FQPA) of 1996 under the 2002 OPP 10X Guidance.  Table 4
is a summary of the toxicology doses and endpoints selected that are
relevant to dietary exposure assessment (TXR# 0052234, 13-NOV-2003). 
The acequinocyl risk assessment team confirmed that the endpoints
selected previously remain appropriate.

Table 4.  Summary of Toxicological Doses and Endpoints for Acequinocyl
for Use in Dietary Exposure Risk Assessment.1

Exposure/

Scenario	Point of Departure	Uncertainty/

FQPA Safety Factors	RfD, PAD, Level of Concern 	Study and Toxicological
Effects

Acute Dietary (General Population, including Infants and Children)	

N/A	

N/A	

N/A	An endpoint of concern (effect) attributable to a single dose was
not identified in the database.  Quantification of acute risk to general
population including infants and children is not required.

Chronic Dietary (All Populations)	NOAEL= 2.7 mg/kg/day	UFA= 10x

UFH=10x

FQPA SF= 1x

	cPAD = cRfD = 0.027 mg/kg/day 

	18-month carcinogenicity study in mice;

LOAEL=7.0 mg/kg/day based on clinical chemistry and microscopic
nonneoplastic lesions (brown pigmented cells and perivascular
inflammatory cells in liver)

1  UF = uncertainty factor, UFA = extrapolation from animal to human
(interspecies), UFH = potential variation in sensitivity among members
of the human population (intraspecies), FQPA SF = FQPA Safety Factor,
NOAEL = no observed adverse effect level, LOAEL = lowest observed
adverse effect level, RfD = reference dose (a = acute, c = chronic), PAD
= population adjusted dose, MOE = margin of exposure, LOC = level of
concern, N/A = Not Applicable, UFDB = database uncertainty factor, UFL =
uncertainty factor for lack of a NOAEL.  

VI.	Results/Discussion 

™ analyses estimate the dietary exposure of the U.S. population and
various population subgroups.  The results reported in Table 5 are for
the general U.S. Population, all infants (<1 year old), children 1-2,
children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49,
and adults 50+ years.  An acute dietary assessment was not conducted for
acequinocyl because an endpoint of concern attributable to a single dose
was not identified; therefore, an aRfD was not established.  A cancer
dietary assessment was not conducted because acequinocyl was classified
as not likely to be carcinogenic to humans.

The chronic dietary exposure assessment (using tolerance level residues
and 100% CT information for all registered and proposed uses) was
conducted for the general U.S. population and various population
subgroups.  Drinking water was incorporated directly into the dietary
assessment using the chronic concentration for ground water generated by
the PRZM/EXAMS model.  This assessment concludes that the chronic
dietary exposure estimates are not of concern to HED for the general
U.S. population (9.8% cPAD) and all population subgroups.  The most
highly exposed population subgroup is children 1-2 years old at 45% of
the cPAD.  The use of ARs, empirical processing factors, and %CT data
would refine further HED’s exposure and risk estimates; however,
refinement is not needed at this time.



Table 5.  Summary of Dietary (Food and Drinking Water) Exposure and Risk
for Acequinocyl.

Population Subgroup	Chronic Dietary1

	Dietary Exposure

(mg/kg/day)	% cPAD

U.S. Population (total)	0.002657	9.8

All Infants (< 1 year old)	0.005584	21

Children 1-2 years old	0.012193	45

Children 3-5 years old	0.008046	30

Children 6-12 years old	0.003657	14

Youth 13-19 years old	0.001855	6.9

Adults 20-49 years old	0.001758	6.5

Adults 50+ years old	0.001811	6.7

Females 13-49 years old	0.001808	6.7

1 Chronic dietary endpoint of 0.027 mg/kg/day applies to the general
U.S. population and all population subgroups.  The values for the
highest exposed population for each type of risk assessment should be
bolded.

VII.	Conclusions

A chronic dietary exposure and risk assessment was conducted for the
proposed food uses and permanent tolerances of acequinocyl, including
potential exposure from drinking water.  

The chronic dietary (food + drinking water) exposure to acequinocyl is
below HED’s level of concern for the general U.S. population and all
population subgroups.  The chronic dietary exposure utilized 9.8% cPAD
for the general U.S. population and 45% of the cPAD for children 1-2
years old, the most highly exposed population subgroup.  An acute
dietary assessment was not conducted for acequinocyl because an endpoint
of concern attributable to a single dose was not identified; therefore,
an aRfD was not established.  A cancer dietary assessment was not
conducted because acequinocyl was classified as not likely to be
carcinogenic to humans.

VIII.		List of Attachments

Attachment 1:  Chronic Food plus Drinking Water Residue Input File.

Attachment 2:  Chronic Results File.

cc:  I. Maher (EFED/ERBI; 7507P)

RDI: DESAC (19-MAY-2010); G.F. Kramer (24-MAY-2010)

S. Levy:S10953:PY1:(703)305-0783:7590P

Attachment 1:  Chronic Food plus Drinking Water Residue Input File.

U.S. Environmental Protection Agency                                Ver.
2.00

DEEM-FCID Chronic analysis for ACEQUINOCYL                       1994-98
data

Residue file: C:\Documents and
Settings\slevy\Desktop\Acequinocyl\006329c.R98

                                                              Adjust. #2
used

Analysis Date 05-26-2010            Residue file dated:
05-26-2010/09:02:01/8

Reference dose (RfD) = 0.027 mg/kg bw/day

Comment:No acute dietary endpoint; not carcinogen.  cRfD=cPAD

------------------------------------------------------------------------
-----

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- ----------------------   ---------- ------     ------  
-------

14000030 14   Almond                             0.020000   1.000     
1.000   

14000031 14   Almond-babyfood                    0.020000   1.000     
1.000   

14000040 14   Almond, oil                        0.020000   1.000     
1.000   

14000041 14   Almond, oil-babyfood               0.020000   1.000     
1.000   

11000070 11   Apple, fruit with peel             0.400000   1.000     
1.000   

11000080 11   Apple, peeled fruit                0.400000   1.000     
1.000   

11000081 11   Apple, peeled fruit-babyfood       0.400000   1.000     
1.000   

11000090 11   Apple, dried                       0.400000   8.000     
1.000   

11000091 11   Apple, dried-babyfood              0.400000   8.000     
1.000   

11000100 11   Apple, juice                       0.400000   1.300     
1.000   

11000101 11   Apple, juice-babyfood              0.400000   1.300     
1.000   

11000110 11   Apple, sauce                       0.400000   1.000     
1.000   

11000111 11   Apple, sauce-babyfood              0.400000   1.000     
1.000   

06010430 6A   Bean, snap, succulent              0.250000   1.000     
1.000   9E7598

06010431 6A   Bean, snap, succulent-babyfood     0.250000   1.000     
1.000   9E7598

21000460 M    Beef, meat byproducts              0.020000   1.000     
1.000   

21000461 M    Beef, meat byproducts-babyfood     0.020000   1.000     
1.000   

21000470 M    Beef, fat                          0.020000   1.000     
1.000   

21000471 M    Beef,fat-babyfood                  0.020000   1.000     
1.000   

21000490 M    Beef, liver                        0.020000   1.000     
1.000   

21000491 M    Beef, liver-babyfood               0.020000   1.000     
1.000   

14000590 14   Brazil nut                         0.020000   1.000     
1.000   

14000680 14   Butternut                          0.020000   1.000     
1.000   

14000810 14   Cashew                             0.020000   1.000     
1.000   

14000920 14   Chestnut                           0.020000   1.000     
1.000   

10001060 10   Citrus citron                      0.200000   1.000     
1.000   

10001070 10   Citrus hybrids                     0.200000   1.000     
1.000   

10001080 10   Citrus, oil                       30.000000   1.000     
1.000   

11001290 11   Crabapple                          0.400000   1.000     
1.000   

08001480 8    Eggplant                           0.700000   1.000     
1.000   9E7598

14001550 14   Filbert                            0.020000   1.000     
1.000   

14001560 14   Filbert, oil                       0.020000   1.000     
1.000   

23001710 M    Goat, fat                          0.020000   1.000     
1.000   

95001750 O    Grape                              1.600000   1.000     
1.000   

95001760 O    Grape, juice                       1.600000   1.000     
1.000   

95001761 O    Grape, juice-babyfood              1.600000   1.000     
1.000   

95001770 O    Grape, leaves                      1.600000   1.000     
1.000   

95001780 O    Grape, raisin                      1.600000   1.000     
1.000   

95001790 O    Grape, wine and sherry             1.600000   1.000     
1.000   

10001800 10   Grapefruit                         0.200000   1.000     
1.000   

10001810 10   Grapefruit, juice                  0.200000   2.100     
1.000   

14001850 14   Hickory nut                        0.020000   1.000     
1.000   

95001880 O    Hop                                4.000000   1.000     
1.000   9E7598

10001970 10   Kumquat                            0.200000   1.000     
1.000   

10001990 10   Lemon                              0.200000   1.000     
1.000   

10002000 10   Lemon, juice                       0.200000   2.000     
1.000   

10002001 10   Lemon, juice-babyfood              0.200000   2.000     
1.000   

10002010 10   Lemon, peel                        0.200000   1.000     
1.000   

10002060 10   Lime                               0.200000   1.000     
1.000   

10002070 10   Lime, juice                        0.200000   2.000     
1.000   

10002071 10   Lime, juice-babyfood               0.200000   2.000     
1.000   

11002100 11   Loquat                             0.400000   1.000     
1.000   

14002130 14   Macadamia nut                      0.020000   1.000     
1.000   

08002340 8    Okra                               0.700000   1.000     
1.000   9E7598

10002400 10   Orange                             0.200000   1.000     
1.000   

10002410 10   Orange, juice                      0.200000   1.800     
1.000   

10002411 10   Orange, juice-babyfood             0.200000   1.800     
1.000   

10002420 10   Orange, peel                       0.200000   1.000     
1.000   

11002660 11   Pear                               0.400000   1.000     
1.000   

11002661 11   Pear-babyfood                      0.400000   1.000     
1.000   

11002670 11   Pear, dried                        0.400000   6.250     
1.000   

11002680 11   Pear, juice                        0.400000   1.000     
1.000   

11002681 11   Pear, juice-babyfood               0.400000   1.000     
1.000   

14002690 14   Pecan                              0.020000   1.000     
1.000   

08002700 8    Pepper, bell                       0.700000   1.000     
1.000   9E7598

08002701 8    Pepper, bell-babyfood              0.700000   1.000     
1.000   9E7598

08002710 8    Pepper, bell, dried                0.700000   1.000     
1.000   9E7598

08002711 8    Pepper, bell, dried-babyfood       0.700000   1.000     
1.000   9E7598

08002720 8    Pepper, nonbell                    0.700000   1.000     
1.000   9E7598

08002721 8    Pepper, nonbell-babyfood           0.700000   1.000     
1.000   9E7598

08002730 8    Pepper, nonbell, dried             0.700000   1.000     
1.000   9E7598

14002820 14   Pistachio                          0.020000   1.000     
1.000   

10003070 10   Pummelo                            0.200000   1.000     
1.000   

11003100 11   Quince                             0.400000   1.000     
1.000   

26003400 M    Sheep, meat byproducts             0.020000   1.000     
1.000   

26003410 M    Sheep, fat                         0.020000   1.000     
1.000   

26003411 M    Sheep, fat-babyfood                0.020000   1.000     
1.000   

95003590 O    Strawberry                         0.400000   1.000     
1.000   

95003591 O    Strawberry-babyfood                0.400000   1.000     
1.000   

95003600 O    Strawberry, juice                  0.400000   1.000     
1.000   

95003601 O    Strawberry, juice-babyfood         0.400000   1.000     
1.000   

10003690 10   Tangerine                          0.200000   1.000     
1.000   

10003700 10   Tangerine, juice                   0.200000   2.300     
1.000   

08003740 8    Tomatillo                          0.700000   1.000     
1.000   9E7598

08003750 8    Tomato                             0.700000   1.000     
1.000   9E7598

08003751 8    Tomato-babyfood                    0.700000   1.000     
1.000   9E7598

08003760 8    Tomato, paste                      0.700000   1.000     
1.000   9E7598

08003761 8    Tomato, paste-babyfood             0.700000   1.000     
1.000   9E7598

08003770 8    Tomato, puree                      0.700000   1.000     
1.000   9E7598

08003771 8    Tomato, puree-babyfood             0.700000   1.000     
1.000   9E7598

08003780 8    Tomato, dried                      0.700000   1.000     
1.000   9E7598

08003781 8    Tomato, dried-babyfood             0.700000   1.000     
1.000   9E7598

08003790 8    Tomato, juice                      0.700000   1.000     
1.000   9E7598

14003910 14   Walnut                             0.020000   1.000     
1.000   

86010000 O    Water, direct, all sources         0.002450   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.002450   1.000     
1.000   

Attachment 2:  Chronic Results File.

U.S. Environmental Protection Agency                                Ver.
2.00

DEEM-FCID Chronic analysis for ACEQUINOCYL                     (1994-98
data)

Residue file name: C:\Documents and
Settings\slevy\Desktop\Acequinocyl\006329c.R98

                                                   Adjustment factor #2
used.

Analysis Date 05-26-2010/09:02:22   Residue file dated:
05-26-2010/09:02:01/8

Reference dose (RfD, Chronic) = .027 mg/kg bw/day

COMMENT 1: No acute dietary endpoint; not carcinogen.  cRfD=cPAD

========================================================================
=====

                    Total exposure by population subgroup

------------------------------------------------------------------------
-----

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.002657                
9.8%

U.S. Population (spring season)             0.002596                
9.6%

U.S. Population (summer season)             0.002685                
9.9%

U.S. Population (autumn season)             0.002656                
9.8%

U.S. Population (winter season)             0.002692               
10.0%

Northeast region                            0.003098               
11.5%

Midwest region                              0.002605                
9.6%

Southern region                             0.002340                
8.7%

Western region                              0.002822               
10.5%

Hispanics                                   0.002932               
10.9%

Non-hispanic whites                         0.002630                
9.7%

Non-hispanic blacks                         0.002535                
9.4%

Non-hisp/non-white/non-black                0.002797               
10.4%

All infants (< 1 year)                      0.005584               
20.7%

Nursing infants                             0.002797               
10.4%

Non-nursing infants                         0.006642               
24.6%

Children 1-6  yrs                           0.008946               
33.1%

Children 7-12 yrs                           0.003387               
12.5%

Females 13-19 (not preg or nursing)         0.001912                
7.1%

Females 20+ (not preg or nursing)           0.001808                
6.7%

Females 13-50 yrs                           0.001991                
7.4%

Females 13+ (preg/not nursing)              0.001997                
7.4%

Females 13+ (nursing)                       0.002049                
7.6%

Males 13-19 yrs   
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Children 1-2 yrs                            0.012193               
45.2%

Children 3-5 yrs                            0.008046               
29.8%

Children 6-12 yrs                           0.003657               
13.5%

Youth 13-19 yrs                             0.001855                
6.9%

Adults 20-49 yrs                            0.001758                
6.5%

Adults 50+ yrs                              0.001811                
6.7%

Females 13-49 yrs                           0.001808                
6.7%

------------------------------------------------------------------------
-----

Acequinocyl	Dietary Exposure and Risk Assessment		DP# 369101	

PC Code:  006329		

________________________________________________________________________
______________

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