Document ID: EPA-HQ-OPP-2006-0331-0007
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2007-07-11T04:00Z

SEQ CHAPTER \h \r 1 

     

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

                                                                        
                                                                        
                                            

                                                                        
                                                                        
        			      OFFICE OF     

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM

DATE:   	6-Apr-07 

SUBJECT:	Cymoxanil: Revised Chronic Aggregate Dietary (Food and Drinking
Water) Exposure Assessment for the Proposed IR-4 Uses on Grapes, Hops
(PP # 5E7000) and Caneberries (PP # 6E7100).

PC Code:	129106			Decision Number: 361987

DP Num: 	338733

REVIEWER:	Susan L. Stanton, Environmental Scientist

		Reregistration Branch III

		Health Effects Division (7509P)

THROUGH:	Amelia Acierto, Chemist

		Thurston Morton, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P); and

Danette Drew, Senior Scientist

Reregistration Branch III

Health Effects Division (7509P)

TO:		Shaja Brothers

		Risk Integration, Minor Use and Emergency Response Branch 

Registration Division (7505P)

On December 5, 2006, the Registration Division ARIA team completed acute
and chronic aggregate dietary risk assessments to support proposed new
uses of cymoxanil on grapes, hops and caneberries (Eugenia McAndrew; DP
Num: 333189; 12/05/06).  The acute assessment was an unrefined, tier 1
assessment.  The partially refined chronic assessment was conducted
using average field trial residues for lettuce and tolerance level
residues for all other commodities.  Chronic exposure estimates were
further refined using screening-level percent crop treated (%CT) data
for several registered commodities and projected %CT data for grapes. 
Concerns have been raised by the Office of General Council regarding the
projected %CT estimate for grapes.  To alleviate these concerns, the
chronic dietary risk assessment has been revised.  In the revised
assessment, the exposure estimates for grapes are based on average field
trial residues with no further adjustment for percent crop treated. 
Processing factors of 1.4x and 1x are applied to grape juice and
raisins, based on the results of a grape processing study.  Average
field trial residues are also being used for hops in the revised
assessment.  No other changes have been made.  Only the revised chronic
dietary risk assessment for cymoxanil is presented in this memorandum. 
The acute dietary risk assessment described in the Debember, 2006
memorandum remains valid.

Executive Summary

M-FCID™), Version 2.03, which uses food consumption data from the U.S.
Department of Agriculture’s Continuing Surveys of  Food Intakes by
Individuals (CSFII) from 1994-1996 and 1998.  The analysis was performed
to support the proposed IR-4 tolerance petitions for the use of
cymoxanil on grapes, hops and caneberries.

The partially refined chronic analysis was conducted for the general
U.S. population and all population subgroups using tolerance level
residues for all commodities except lettuce, hops and grapes.  Average
residues from field trials were used for lettuce, hops and grapes.  DEEM
default processing factors were used for all commodities except grapes. 
Processing factors for grape juice (1.4x) and raisins (1x) were derived
from grape processing data.  Exposure estimates were further refined
using screening-level percent crop treated (% CT) data for several
registered commodities.  For all other commodities, including the
proposed new uses, 100%CT was assumed.

Drinking water was incorporated directly into the dietary assessment
using the chronic estimated drinking water concentration of 0.0001 ppm
generated using the FIRST (version 1.0) model for surface water.

Chronic Dietary Exposure Results 

Chronic dietary exposure estimates for food and drinking water combined
are below HED’s level of concern.  Using the DEEM-FCID™ software,
dietary exposure is estimated at 0.000271 mg/kg/day for the general U.S.
population (34% of the chronic Population Adjusted Dose (cPAD)) and
0.000405 mg/kg/day (51% of the cPAD) for children 1 to 2 years old, the
population subgroup with the highest estimated chronic dietary exposure
to cymoxanil.

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to the point of departure (POD; e.g.,
NOAEL, LOAEL) divided by the appropriate uncertainty or safety factors.

For non-cancer chronic exposures, HED is concerned when estimated
dietary risk exceeds 100% of the PAD.  References which discuss the
chronic risk assessment in more detail are available on the
EPA/pesticides web site:  “Available Information on Assessing Exposure
from Pesticides, A User’s Guide,” 6/21/2000, web link:     
HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see
SOP 99.6 (8/20/99).

The most recent HED dietary risk assessment for cymoxanil (S. Levy, DP
Num: 276292, 04/DEC/2002) was conducted to support the FIFRA §3 food
uses on hops, lychee, fruiting vegetables, head lettuce and cucurbits.

Food Residue Information

A. Tolerance Expression and Residues of Concern for the
Registered/Proposed Crops

An ad hoc MARC met on 21/JAN/1998 and decided that parent only is of
regulatory concern (G. Kramer, et. al., DP Num: 242321, 26/JAN/1998) in
tomatoes, potatoes, grapes, livestock, rotational crops and drinking
water.  Subsequent to the initial MARC meeting, the petitioner submitted
a lettuce metabolism study (MRID 44944605).  Metabolites IN-KQ960 and
IN-KP533 are present in the lettuce metabolism study which were not
present in the tomato, grape, potato or rat metabolism studies.  The
lettuce metabolism results were presented to the HED MARC to assess the
toxicological significance of these metabolites and to determine which
additional residues, if any, to regulate in lettuce. 

The MARC concluded (S. Levy, DP Num: 276796, 30/AUG/2001) that for the
tolerance expression the residue of concern in/on hops is cymoxanil per
se.  For risk assessment purposes for hops and lettuce, the metabolite
IN-KQ960 must be included, along with the parent, based on the ratio of
IN-KQ960 to the parent in the lettuce 14C metabolism study.  For any
future petitions for tolerance on leafy vegetables, the petitioner was
instructed to include residue data for IN-KQ960.  The final decision
concerning the tolerance expression in lettuce and other leafy
vegetables is deferred pending results of the residue studies. 

Tolerances are currently established under 40 CFR 180.503 for grape (0.1
ppm, imports only), hop, dried cones (1.0 ppm), lettuce, head (4.0 ppm),
lychee (1.0 ppm), potato, (0.05 ppm), vegetable, cucurbit, group 9 (0.05
ppm) and vegetable, fruiting, group 8 (0.2 ppm).  IR-4 has proposed
adding caneberries (4 ppm) and increasing the grape tolerance to 1 ppm
and the dried hop tolerance to 5 ppm.  The increased tolerance for
grapes is being requested to support domestic use of cymoxanil on
grapes.  The increased tolerance for dried hop is being requested to
support a different formulation which results in higher field trial
residues.  RD’s ARIA team has reviewed the residue chemistry data
associated with the current request.  These data do not support
increasing the tolerance for grapes from 0.1 to 1.0 ppm.  The data
indicate that the tolerance for hop should be increased from 1.0 to 7.0
ppm.  ARIA concludes that the following tolerances for residues of
cymoxanil are appropriate (D. Rate; DP Num: 324447; 02/06/07):

Grape 			0.1 ppm

Hop, dried cones	7.0 ppm  

Caneberries		4.0 ppm     

There are no livestock feedstuffs associated with the proposed uses on
grapes, hops and caneberries; therefore, tolerances for livestock
commodities are not required.     

B. Residue Data used in the Chronic Dietary Analysis

The partially refined chronic analysis was conducted using tolerance
level residues for all commodities except lettuce, hops and grapes. 
Average residues from field trials conducted at maximum application
rates were used for lettuce (MRID 44946430; S. Levy, 11/20/02) and hops
(MRID 44670201; D. Rate; 11/06/06).  Separate field trials were
conducted to support the existing import tolerance on grapes and the
proposed domestic use on grapes.  Slightly higher residues were found in
the imported grape field trials, most likely due to the shorter PHI in
the imported trials (14 vs. 28 days).  A conservative anticipated
residue for grapes was calculated by taking the average of grape
residues from the imported grape field trials (MRID 43616533; G. Kramer;
04/25/1996), incorporating ½ the Limit of Detection for non-detectable
residues.  This value was used for all grapes in the chronic assessment,
including domestically grown grapes.

Exposure estimates were further refined based on screening-level percent
crop treated (% CT) data provided by BEAD for cucumbers, lettuce,
peppers, potatoes, pumpkins, squash, tomatoes and watermelons [Cymoxanil
Screening- level Usage Analysis (SLUA),  J. Carter, 11/02/06].  For all
other registered and proposed commodities, 100%CT was assumed.

DEEM ver. 7.81 default processing factors were used for all processed
food commodities except grape juice and raisins.  A concentration factor
of 1.4x was applied to grape juice based on the results of the grape
processing study (MRID 43616534; G. Kramer; 04/25/96).  The processing
factor for raisins was set to 1x based on the results of this same
study.

The residue data, %CT estimates and processing factors used in the
chronic assessment are summarized in Table 1.

Table # 1.  Residue Data used in the Chronic Dietary Analysis for
Cymoxanil

Commodity	Residue	Percent Crop Treated	Processing Factors

Grape	0.0285 ppm

(average field trial)	             100	Juice (1.4x)

Raisins (1x)

MRID 43616534

Hop, dried cones1	9.4 ppm 

(average field trial  + metabolite)	            100	1x

Lettuce, head2	 3.15 ppm 

(average field trial + metabolite)	              10	1x

Lychee	 1.0   ppm (tolerance)	             100	Dried  1.85

Potato	 0.05 ppm (tolerance)	               10	Dried  6.5

Cucurbit Vegetables (Group 9)	 0.05 ppm (tolerance)	Cucumber       10

Pumpkin           1

Squash              1

Watermelon      1

All others      100	1x

Fruiting vegetables

(Group 8)	 0.2  ppm (tolerance)	Tomatoes        10

Peppers           10

All others      100

	Tomato paste  5.4

Tomato puree 3.3

Tomato dried 14.3

Tomato juice  1.5

Caneberries

(Subgroup 13A)	  4.0 ppm (tolerance)	              100	1x

 

1 Average residue from imported hop field trials + (3.5 x average FT
residue) = 2.09 ppm + ( 3.5 x 2.09) = 9.4 ppm

2 Average FT + (3.5 x Average FT) = 0.7 ppm + (3.5 x 0.7 ppm) = 3.15 ppm

 Drinking Water Data 

References: IR-4 Tolerance Petition for Cymoxanil (Tanos) Use on Grapes,
Hops: DW Assessment; D.Young and T. Steeger, 20/SEPT/2006, DP Num:
323681 and IR-4 Tolerance Petition for Cymoxanil (Tanos) Use on
Caneberries: DW Assessment; D.Young and T. Steeger,  21/SEPT/2006, DP
Num: 331978

The Environmental Fate and Effects Division (EFED) calculated screening
level surface water and ground water estimates for cymoxanil using FIRST
(version 1.0) model and the SCI-GROW model, respectively. The drinking
water models and their descriptions are available at the EPA internet
site:   HYPERLINK "http://www.epa.gov/oppefed1/models/water/" 
http://www.epa.gov/oppefed1/models/water/ .  The newly proposed
application rates for use on grapes and hops are higher than the rates
evaluated in the previous Section 3 registration for the use of
cymoxanil on potatoes (DP Num: 233366) and for the initial IR-4
tolerance petition for use of cymoxanil (Curzate 60 DF) on hops (DP Num:
271572).  Therefore new drinking water concentrations were determined
for the proposed uses. Tier 1 drinking water concentrations (EDWCs)
based on the newly proposed application rate for grapes appear in Table
2 as follows:

Table #2.  Estimated drinking water concentrations for Cymoxanil1

	Acute  (ppm)	Chronic  (ppm)

Groundwater	0.000003	0.000003

Surface Water	0.019	0.0001

1 Concentrations determined from the grape application (0.25 lbs per
acre, 10 times), which was the highest application rate reported for the
new proposed uses.

The higher chronic EDWC for surface water (0.0001 ppm) was used in this
dietary exposure assessment. The drinking water EDWC was incorporated
directly as a point estimate in the DEEM analysis under the food
categories “water, direct, all sources” and “water, indirect, all
sources.”   

IV.	DEEM-FCID™ Program and Consumption Information

A cymoxanil chronic dietary exposure assessment was conducted using the
Dietary Exposure Evaluation Model software with the Food Commodity
Intake Database (DEEM-FCID™, Version 2.03), which incorporates
consumption data from USDA’s Continuing Surveys of Food Intakes by
Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98 data are based
on the reported consumption of more than 20,000 individuals over two
non-consecutive survey days.  Foods “as consumed” (e.g., apple pie)
are linked to EPA-defined food commodities (e.g. apples, peeled fruit -
cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S,
baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA.  For chronic exposure assessment,
consumption data are averaged for the entire U.S. population and within
population subgroups, but for acute exposure assessment are retained as
individual consumption events.  Based on analysis of the 1994-96, 98
CSFII consumption data, which took into account dietary patterns and
survey respondents, HED concluded that it is most appropriate to report
risk for the following population subgroups: the general U.S.
population, all infants (<1 year old), children 1-2, children 3-5,
children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+
years old.

For chronic dietary exposure assessments, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

Toxicological Information

The toxicological endpoints and doses chosen for dietary risk assessment
are summarized below in Table 3.



Table # 3.  Summary of Cymoxanil Toxicological Doses and Endpoints for
Dietary Risk Assessment

Exposure

Scenario	

Dose Used in Risk Assessment, UF 	

Special FQPA SF* and Level of Concern for Risk Assessment	

Study and Toxicological Effects

Acute Dietary

(Females 13-50 years of age)	

NOAEL = 4 mg/kg

UF = 100

Acute RfD = 0.04 mg/kg	

FQPA SF = 1X

aPAD = acute RfD

              FQPA SF

= 0.04 mg/kg	

Developmental Toxicity (rabbit)

Offspring LOAEL = 8 mg/kg/day  based on increased skeletal malformations
of he cervical and thoracic vertebrae and ribs

Acute Dietary

(General population including infants and children)	

NOAEL = NA

UF = NA

Acute RfD = NA 	

FQPA SF =  NA

aPAD = acute RfD

              FQPA SF

= NA	

Not Required.  An endpoint of concern (effect) attributable to a single
dose was not identified in the database. 

Chronic Dietary

(All populations)	

NOAEL< 0.8 mg/kg/day

UF = 100

Chronic RfD = 0.008

 mg/kg/day	

FQPA SF1 = 10X

(includes UFL =  10X 

cPAD = chronic RfD

               FQPA SF

= 0.0008 mg/kg/day	

Chronic toxicity (dog; 2003)

LOAEL = 1.3/0.8 mg/kg/day (M/F), based on decreased absolute and
relative thymus weights and histopathology of the thymus (thymic
atrophy/involution) in males and decreased thymus weights in females

UF = uncertainty factor, FQPA SF = Special FQPA safety factor, NOAEL =
no-observed-adverse-effect-level, LOAEL =
lowest-observed-adverse-effect-level, PAD = population adjusted dose (a
= acute, c = chronic) RfD = reference dose, NA = Not Applicable 

1  The 10X FQPA SF has been retained in the form of UFL to account for
the use of a LOAEL to extrapolate a NOAEL.

VI.	Results/Discussion 

concerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID™
analyses estimate the dietary exposure of the U.S. population and
various population subgroups.  The chronic exposure results reported in
Table # 4 are for the general U.S. Population, all infants (<1 year
old), children 1-2, children 3-5, children 6-12, youth 13-19, females
13-49, adults 20-49, and adults 50+ years.  

Results of Chronic Dietary Exposure Analysis

FCID™ software are below HED’s level of concern for the general U.S.
population and each of the population subgroups.  Dietary exposure was
estimated at 0.000271 mg/kg/day for the U.S. population         (34% of
the cPAD) and 0.000405 mg/kg/day (51% of the cPAD) for the most highly
exposed population subgroup (children, 1-2 years old).  The estimated
exposures/risks for food and water combined are summarized in Table # 4
for all populations.

Table # 4.  Results of Chronic Dietary Exposure Analysis for Cymoxanil1

Population Subgroup	

cPAD

(mg/kg/day)	

Exposure (mg/kg/day)	

% cPAD

General U.S. Population	0.0008	0.000271	34

All Infants (< 1 year old)	0.0008	0.000147	18

Children 1-2 years old	.0008	0.000405	51

Children 3-5 years old	0.0008	0.000389	49

Children 6-12 years old	0.0008	0.000263	33

Youth 13-19 years old	0.0008	0.000202	25

Adults 20-49 years old	0.0008	0.000293	37

Females 13-49 years old	0.0008	0.000233	29

Adults 50+ years old	0.0008	0.000219	27

1The population subgroup with the highest estimated chronic dietary
(food + drinking water) exposure and risk is indicated by bold text.

VII.	Characterization of Inputs/Outputs

This chronic dietary exposure assessment for cymoxanil is a partially
refined assessment which incorporates average field trial residues for
lettuce, hops and grapes as well as screening level % CT data for
several registered commodities.  Dietary exposure estimates could be
further refined through the use of additional anticipated residues as
well as refined EDWCs.  Since the estimated exposures using the current
assumptions are below HED’s level of concern, additional refinements
are not warranted at this time. 

VIII.	Conclusions

ID™ indicates that dietary exposures to cymoxanil from food and
drinking water are below HED’s level of concern for this pesticide. 
Estimated chronic dietary exposures are less than or equal to 51% of the
cPAD for the general U.S. population and all population subgroups.

IX.		List of Attachments

Chronic Food + Drinking Water Input File

Chronic Food + Drinking Water Results File

Chronic Food + Water Input File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for CYMOXANIL                         
1994-98 data

Residue file: C:\Documents and Settings\sstanton\My Documents\DEEM-FCID
Files\cymoxanil\chronic food + water.R98

                                                               Adjust.
#2 used

Analysis Date 04-05-2007             Residue file dated:
04-05-2007/13:35:08/8

Reference dose (RfD) = 0.0008 mg/kg bw/day

Comment:Cymoxanil chronic food + water using mean FT for lettuce, grape
& hop; SLUA %CT for registered uses.

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

09020210 9B   Balsam pear                        0.050000   1.000     
1.000   

13010550 13A  Blackberry                         4.000000   1.000     
1.000   

13010560 13A  Blackberry, juice                  4.000000   1.000     
1.000   

13010561 13A  Blackberry, juice-babyfood         4.000000   1.000     
1.000   

13010580 13A  Boysenberry                        4.000000   1.000     
1.000   

09010750 9A   Cantaloupe                         0.050000   1.000     
1.000   

09010800 9A   Casaba                             0.050000   1.000     
1.000   

09020880 9B   Chayote, fruit                     0.050000   1.000     
1.000   

09021020 9B   Chinese waxgourd                   0.050000   1.000     
1.000   

09021350 9B   Cucumber                           0.050000   1.000     
0.100   

13011420 13A  Dewberry                           4.000000   1.000     
1.000   

08001480 8    Eggplant                           0.200000   1.000     
1.000   

95001750 O    Grape                              0.028500   1.000     
1.000   

95001760 O    Grape, juice                       0.028500   1.400     
1.000   

95001761 O    Grape, juice-babyfood              0.028500   1.400     
1.000   

95001770 O    Grape, leaves                      0.028500   1.000     
1.000   

95001780 O    Grape, raisin                      0.028500   1.000     
1.000   

95001790 O    Grape, wine and sherry             0.028500   1.000     
1.000   

09011870 9A   Honeydew melon                     0.050000   1.000     
1.000   

95001880 O    Hop                                9.400000   1.000     
1.000   

04012040 4A   Lettuce, head                      3.150000   1.000     
0.100   

13012080 13A  Loganberry                         4.000000   1.000     
1.000   

95002110 O    Lychee                             1.000000   1.000     
1.000   

95002120 O    Lychee, dried                      1.000000   1.850     
1.000   

08002340 8    Okra                               0.200000   1.000     
1.000   

08002700 8    Pepper, bell                       0.200000   1.000     
0.100   

08002701 8    Pepper, bell-babyfood              0.200000   1.000     
0.100   

08002710 8    Pepper, bell, dried                0.200000   1.000     
0.100   

08002711 8    Pepper, bell, dried-babyfood       0.200000   1.000     
0.100   

08002720 8    Pepper, nonbell                    0.200000   1.000     
0.100   

08002721 8    Pepper, nonbell-babyfood           0.200000   1.000     
0.100   

08002730 8    Pepper, nonbell, dried             0.200000   1.000     
0.100   

01032960 1C   Potato, chips                      0.050000   1.000     
0.100   

01032970 1C   Potato, dry (granules/ flakes)     0.050000   6.500     
0.100   

01032971 1C   Potato, dry (granules/ flakes)-b   0.050000   6.500     
0.100   

01032980 1C   Potato, flour                      0.050000   1.000     
0.100   

01032981 1C   Potato, flour-babyfood             0.050000   1.000     
0.100   

01032990 1C   Potato, tuber, w/peel              0.050000   1.000     
0.100   

01032991 1C   Potato, tuber, w/peel-babyfood     0.050000   1.000     
0.100   

01033000 1C   Potato, tuber, w/o peel            0.050000   1.000     
0.100   

01033001 1C   Potato, tuber, w/o peel-babyfood   0.050000   1.000     
0.100   

09023080 9B   Pumpkin                            0.050000   1.000     
0.010   

09023090 9B   Pumpkin, seed                      0.050000   1.000     
0.010   

13013200 13A  Raspberry                          4.000000   1.000     
1.000   

13013201 13A  Raspberry-babyfood                 4.000000   1.000     
1.000   

13013210 13A  Raspberry, juice                   4.000000   1.000     
1.000   

13013211 13A  Raspberry, juice-babyfood          4.000000   1.000     
1.000   

09023560 9B   Squash, summer                     0.050000   1.000     
0.010   

09023561 9B   Squash, summer-babyfood            0.050000   1.000     
0.010   

09023570 9B   Squash, winter                     0.050000   1.000     
0.010   

09023571 9B   Squash, winter-babyfood            0.050000   1.000     
0.010   

08003740 8    Tomatillo                          0.200000   1.000     
1.000   

08003750 8    Tomato                             0.200000   1.000     
0.100   

08003751 8    Tomato-babyfood                    0.200000   1.000     
0.100   

08003760 8    Tomato, paste                      0.200000   5.400     
0.100   

08003761 8    Tomato, paste-babyfood             0.200000   5.400     
0.100   

08003770 8    Tomato, puree                      0.200000   3.300     
0.100   

08003771 8    Tomato, puree-babyfood             0.200000   3.300     
0.100   

08003780 8    Tomato, dried                      0.200000  14.300     
0.100   

08003781 8    Tomato, dried-babyfood             0.200000  14.300     
0.100   

08003790 8    Tomato, juice                      0.200000   1.500     
0.100   

86010000 O    Water, direct, all sources         0.000100   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.000100   1.000     
1.000   

09013990 9A   Watermelon                         0.050000   1.000     
0.010   

09014000 9A   Watermelon, juice                  0.050000   1.000     
0.010   

Chronic Food + Water Results File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for CYMOXANIL                        (1994-98
data)

Residue file name: C:\Documents and Settings\sstanton\My
Documents\DEEM-FCID Files\cymoxanil\chronic food + water.R98

                                                     Adjustment factor
#2 used.

Analysis Date 04-05-2007/13:36:53     Residue file dated:
04-05-2007/13:35:08/8

Reference dose (RfD, Chronic) = .0008 mg/kg bw/day

COMMENT 1: Cymoxanil chronic food + water using mean FT for lettuce,
grape & hop; SLUA %CT for registered uses.

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.000271               
33.9%

U.S. Population (spring season)             0.000282               
35.2%

U.S. Population (summer season)             0.000307               
38.4%

U.S. Population (autumn season)             0.000249               
31.2%

U.S. Population (winter season)             0.000247               
30.9%

Northeast region                            0.000255               
31.8%

Midwest region                              0.000287               
35.9%

Southern region                             0.000229               
28.6%

 

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摧䢹"ᴀ          0.000337                42.2%

Hispanics                                   0.000244               
30.5%

Non-hispanic whites                         0.000295               
36.8%

Non-hispanic blacks                         0.000174               
21.8%

Non-hisp/non-white/non-black                0.000232               
29.0%

All infants (< 1 year)                      0.000147               
18.3%

Nursing infants                             0.000090               
11.3%

Non-nursing infants                         0.000168               
21.0%

Children 1-6  yrs                           0.000387               
48.4%

Children 7-12 yrs                           0.000248               
31.0%

Females 13-19 (not preg or nursing)         0.000174               
21.7%

Females 20+ (not preg or nursing)           0.000223               
27.9%

Females 13-50 yrs                           0.000227               
28.4%

Females 13+ (preg/not nursing)              0.000153               
19.1%

Females 13+ (nursing)                       0.000203               
25.3%

Males 13-19 yrs                             0.000229               
28.6%

Males 20+ yrs                               0.000325               
40.6%

Seniors 55+                                 0.000212               
26.5%

Children 1-2 yrs                            0.000405               
50.6%

Children 3-5 yrs                            0.000389               
48.6%

Children 6-12 yrs                           0.000263               
32.9%

Youth 13-19 yrs                             0.000202               
25.2%

Adults 20-49 yrs                            0.000293               
36.7%

Adults 50+ yrs                              0.000233               
29.1%

Females 13-49 yrs                           0.000219               
27.4%

------------------------------------------------------------------------
-------

Cymoxanil                       Dietary Exposure Assessment             
           DP Num: 338733               PC Code: 129106                 
                                	

Page   PAGE  1  of   NUMPAGES  11