Document ID: EPA-HQ-OPP-2005-0220-0007
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2005-09-08T04:00Z

Page
1
of
9
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
August
29,
2005
MEMORANDUM:

SUBJECT:
Dicofol.
Revised
Refined
Post­
Application
Exposure
Estimates
(
Hops,
Mint,
Strawberries).

FROM:
Robert
Travaglini,
Chemist
Reregistration
Branch
3
Health
Effects
Division
(
7509C)

THRU:
Steven
Weiss,
Senior
Scientist
Reregistration
Branch
3
Health
Effects
Division
(
7509C)

TO:
Mika
Hunter,
Chemical
Review
Manager
Reregistration
Branch
3
Special
Review
and
Reregistration
Division
(
7508C)

DP
Barcode:
D
321185
PC
Code:
010501
This
memorandum
addresses
the
error­
correction
response
dated
August
17,
2005
from
Dow
Agrosciences
pertaining
to
the
HED
document
of
June
9,
2005
which
concerned
postapplication
exposures
and
risk
estimates
for
the
insecticide/
miticide
dicofol
on
hops,
mints
and
strawberries.
A
memorandum
which
addresses
the
Dow
Agrosciences
comments
is
attached.

This
document
reflects
current
HED
policy.
This
memorandum
examines
post­
application
exposures
and
risk
estimates
for
the
insecticide/
miticide
dicofol,
in
continuation
of
the
reregistration
(
RED)
process
for
this
pesticide.
On
May
27,
2005
Special
Review
and
Reregistration
Division
(
SRRD)
requested
that
HED
provide
for
inclusion
in
an
addendum
to
the
Dicofol
RED,
the
re­
entry
Interval
(
REI)
and
postapplication
dermal
exposure
estimates
for
three
additional
crops
not
previously
assessed.
These
crops
are:
hops,
mint
and
strawberries.

Background
&
Summary
In
November,
1999
HED
issued
a
revised
Occupational
Exposure
Assessment
for
the
miticide
dicofol
(
D260940).
A
short­
term
NOAEL
of
75
mg/
kg/
day
and
intermediate­
term
NOAEL
of
3
mg/
kg/
day
were
used
as
the
endpoints
in
the
assessment.
Since
these
endpoints
were
taken
from
dermal
studies,
a
dermal
absorption
factor
of
100%
was
utilized.
The
target
MOE
for
dermal
exposures
is
100.
Subsequent
to
the
1999
RED,
SRRD
has
requested
and
HED
has
provided
post­
application
dermal
exposure
estimates
for
various
crop
uses
that
are
being
supported
in
the
RED
process.
Post­
application
dermal
exposure
estimates
have
recently
been
provided
to
SRRD
for
the
following
crops:
apples,
apricots,
beans
(
dry,
string),
cotton,
cucurbits,
grapefruit,
grapes,
oranges,
peaches,
pecans,
peppers
(
bell
&
chili),
oranges,
&
treated
sod.
Generally
in
these
assessments,
the
short­
term
post­
application
MOEs
for
all
exposure
scenarios
were
not
of
concern
and
were
exceeded
usually
within
2
days
after
the
dicofol
treatment.
However,
the
intermediate­
term
REIs
for
many
potential
post­
application
exposure
activities
were
between
20
and
30
days
and
in
some
cases
(
i.
e.
hand
harvesting
oranges)
were
as
long
as
87
days,
exceeding
existing
label
re­
entry
language
by
several
weeks.

Where
possible
in
these
assessments,
HED
used
chemical
specific
dislodgeable
foliar
residue
(
DFR)
data
to
estimate
the
post­
application
dermal
exposure
for
the
various
treated
crops.
However,
for
the
remaining
crops
and
for
the
crops
assessed
in
this
document,
HED
relied
on
default
DFR
calculations
using
the
HED
Exposure
SAC
SOP#
3
"
Agricultural
transfer
Coefficients"
to
determine
REIs.

For
short­
term
post
application
dermal
exposures
to
the
assessed
crops
treated
with
dicofol,
MOEs
exceeded
100
at
0
­
1
days
after
treatment
(
DAT)
for
all
post­
application
exposure
activities.

For
intermediate­
term
post­
application
dermal
exposures
to
dicofol
treated
hops,
mint
and
strawberries,
MOES
exceeded
100
for
low
exposure
activities:
0
DAT
(
hops),
1
DAT
(
mint),
and,
19
DAT
(
strawberries).
For
medium
exposure
activities,
MOEs
exceeded
100
on
25
DAT
(
hops)
and
27
DAT
(
mint).
For
high
exposure
activities
MOES
exceeded
100
on
30
DAT
(
hops),
31
DAT
(
strawberries)
and
32
DAT
(
mint).

Attachments
for
this
document
are
the
appendices
for
the
short
and
intermediate­
term
post­
application
re­
entry
interval
(
REI)
calculations,
which
include
data
inputs
and
tables.

This
document
reflects
current
HED
policy.
Page
3
of
9
Table
1.
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Short­
term
Exposure:
Hops
Crop
Grouping
(
1)
dicofol
­
hops
Specific
Crops
(
2)
Max
Foliar
Rate
(
lb
ai/
acre)
(
2)
Days
After
Treatment
Target
MOE
Achieved
(
Target
MOE
=
100)

Exposure
Activity
Levels
(
3,4)

Very
Low
Low
Medium
High
Very
High
Bunch
/
bundle
Hops
1.16
N/
A
0
0
0
N/
A
Table
2.
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Intermediate­
term
Exposure:
Hops
Crop
Grouping
(
1)
dicofol
­
hops
Specific
Crops
(
2)
Max
Foliar
Rate
(
lb
ai/
acre)
Days
After
Treatment
Target
MOE
Achieved
(
Target
MOE
=
100)

Exposure
Activity
Levels
(
3,4)

Very
Low
Low
Medium
High
Very
High
Bunch
/
bundle
Hops
1.16
N/
A
0
25
29
N/
A
Footnote:

1.
Crop
groupings
and
transfer
coefficients
from
Science
Advisory
Council
for
Exposure:
Policy
Memo
#
003.1
'
Agricultural
Transfer
Coefficients',
August
17,
2000.

2.
Maximum
label
rates
from
end
use
product
labels.

3.
DAT
=
Days
after
treatment;
DAT0
=
On
the
day
of
treatment,
after
sprays
have
dried;
assumed
approximately
12
hours.

4.
MOE
=
Dermal
toxicity
endpoint
(
mg/
kg­
day)/
absorbed
dermal
dose
(
mg/
kg­
d)
where
the
absorbed
dose
=
DFR
(
ug/
cm2)
x
TC
(
cm2/
hr)
x
conversion
factor
(
1
mg/
1,000
ug)
x
exposure
time
(
hrs)
x
dermal
absorption
/
body
weight
(
kg).

Chemical:
dicofol
­
hops
Date:
6­
8­
05
Assessor:
travaglini
Transfer
Coefficient
Group:
Bunch
/
bundle
Specific
Crop
Considered:
Hops
Application
Rate
of
Crop
(
lb
ai/
A):
1.16
DFR
Data
Summary
Page
4
of
9
No
study
data
was
used
for
this
crop's
assessment.

Exposure
Inputs
Summary
Exposure
Potential
Transfer
Coefficients
(
cm2/
hr)
(
1)
Activities
(
1)

Used
for
RA
Range
Very
Low
N/
A
N/
A
N/
A
Low
100
TBD
Irrigation,
Weeding
(
hand),
Scouting,
Thinning
Medium
1300
1,346
­
2,308
Irrigation,
Scouting
High
2000
1,346
­
2,308
Harvest
(
hand),
Harvest
(
mechanical),

Stripping,
Training,
Pruning
(
hand),
Thinning,

Topping,
Weeding
(
hand)

Very
High
N/
A
N/
A
N/
A
Page
5
of
9
Table
3.
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Short­
term
Exposure:
Mint
Crop
Grouping
(
1)
dicofol
­
mint
@
1.25
Specific
Crops
(
2)
Max
Foliar
Rate
(
lb
ai/
acre)
(
2)
Days
After
Treatment
Target
MOE
Achieved
(
Target
MOE
=
100)

Exposure
Activity
Levels
(
3,4)

Very
Low
Low
Medium
High
Very
High
Field
/
row
crops,
low
/

medium
Mint
1.25
N/
A
0
0
1
N/
A
Table
4.
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Intermediate­
term
Exposure:
Mint
Crop
Grouping
(
1)
dicofol
­
mint
@
1.25
Specific
Crops
(
2)
Max
Foliar
Rate
(
lb
ai/
acre)
Days
After
Treatment
Target
MOE
Achieved
(
Target
MOE
=
100)

Exposure
Activity
Levels
(
3,4)

Very
Low
Low
Medium
High
Very
High
Field
/
row
crops,
low
/

medium
Mint
1.25
N/
A
1
27
32
N/
A
Footnote:

1.
Crop
groupings
and
transfer
coefficients
from
Science
Advisory
Council
for
Exposure:
Policy
Memo
#
003.1
'
Agricultural
Transfer
Coefficients',
August
17,
2000.

2.
Maximum
label
rates
from
end
use
product
labels.

3.
DAT
=
Days
after
treatment;
DAT0
=
On
the
day
of
treatment,
after
sprays
have
dried;
assumed
approximately
12
hours.

4.
MOE
=
Dermal
toxicity
endpoint
(
mg/
kg­
day)/
absorbed
dermal
dose
(
mg/
kg­
d)
where
the
absorbed
dose
=
DFR
(
ug/
cm2)
x
TC
(
cm2/
hr)
x
conversion
factor
(
1
mg/
1,000
ug)
x
exposure
time
(
hrs)
x
dermal
absorption
/
body
weight
(
kg).

Chemical:
dicofol
­
mint
@
1.25
Date:
6­
8­
05
Assessor:
travaglini
Transfer
Coefficient
Group:
Field
/
row
crops,
low
/
medium
Specific
Crop
Considered:
Mint
Application
Rate
of
Crop
(
lb
ai/
A):
1.25
DFR
Data
Summary
No
study
data
was
used
for
this
crop's
assessment.
Page
6
of
9
Exposure
Inputs
Summary
Exposure
Potential
Transfer
Coefficients
(
cm2/
hr)
(
1)
Activities
(
1)

Used
for
RA
Range
Very
Low
N/
A
N/
A
N/
A
Low
100
TBD
Irrigation,
Scouting,
Weeding
(
hand),
Thinning
Medium
1500
486
­
2,760
Irrigation,
Scouting,
Weeding
(
hand)

High
2500
486
­
2,760
Harvest
(
hand)

Very
High
N/
A
N/
A
N/
A
Page
7
of
9
Table
5.
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Short­
term
Exposure:
Strawberries
Crop
Grouping
(
1)
dicofol­
strawberries@
2
.0
Specific
Crops
(
2)
Max
Foliar
Rate
(
lb
ai/
acre)
(
2)
Days
After
Treatment
Target
MOE
Achieved
(
Target
MOE
=
100)

Exposure
Activity
Levels
(
3,4)

Very
Low
Low
Medium
High
Very
High
Berry,
low
Strawberries
2
N/
A
0
N/
A
1
N/
A
Table
6.
Summary
of
'
Days
After
Treatment'
to
Reach
the
Target
MOE
for
Intermediate­
term
Exposure:
Strawberries
Crop
Grouping
(
1)
dicofol­
strawberries@
2
.0
Specific
Crops
(
2)
Max
Foliar
Rate
(
lb
ai/
acre)
Days
After
Treatment
Target
MOE
Achieved
(
Target
MOE
=
100)

Exposure
Activity
Levels
(
3,4)

Very
Low
Low
Medium
High
Very
High
Berry,
low
Strawberries
2
N/
A
19
N/
A
31
N/
A
Footnote:

1.
Crop
groupings
and
transfer
coefficients
from
Science
Advisory
Council
for
Exposure:
Policy
Memo
#
003.1
'
Agricultural
Transfer
Coefficients',
August
17,
2000.

2.
Maximum
label
rates
from
end
use
product
labels.

3.
DAT
=
Days
after
treatment;
DAT0
=
On
the
day
of
treatment,
after
sprays
have
dried;
assumed
approximately
12
hours.

4.
MOE
=
Dermal
toxicity
endpoint
(
mg/
kg­
day)/
absorbed
dermal
dose
(
mg/
kg­
d)
where
the
absorbed
dose
=
DFR
(
ug/
cm2)
x
TC
(
cm2/
hr)
x
conversion
factor
(
1
mg/
1,000
ug)
x
exposure
time
(
hrs)
x
dermal
absorption
/
body
weight
(
kg).

DFR/
TTR
Data
Defaults:

Initial
Percent
of
Rate
as
DFR
(%):
20
Dissipation
Rate
per
day
(%):
10
Initial
Percent
of
Rate
as
TTR
(%):
5
Dissipation
Rate
per
day
(%):
10
Chemical:
dicofol­
strawberries@
2.0
Date:
6­
7­
05
Assessor:
travaglini
Transfer
Coefficient
Group:
Berry,
low
Specific
Crop
Considered:
Strawberries
Page
8
of
9
Application
Rate
of
Crop
(
lb
ai/
A):
2
DFR
Data
Summary
No
study
data
was
used
for
this
crop's
assessment.

Exposure
Inputs
Summary
Exposure
Potential
Transfer
Coefficients
(
cm2/
hr)
(
1)
Activities
(
1)

Used
for
RA
Range
Very
Low
N/
A
N/
A
N/
A
Low
400
400
­
1,800
Scouting,
Weeding
(
hand),
Irrigation,
Pruning
(
hand),
Thinning,
Harvest
(
hand)
(
raking),

Pruning
(
hand)
(
shears),
Mulching
Medium
N/
A
N/
A
N/
A
High
1500
400
­
1,800
Harvest
(
hand),
Pruning
(
hand),
Pinching,

Training
Very
High
N/
A
N/
A
N/
A
Page
9
of
9