Document ID: EPA-HQ-OPPT-2009-0477-0074
Agency: epa
Document Type: Notice
Title: Endocrine Disruptor Screening Program: Final Second List of Chemicals and Substances for Tier 1 Screening
Posted Date: 2013-06-14T04:00Z

[Federal Register Volume 78, Number 115 (Friday, June 14, 2013)]
[Notices]
[Pages 35922-35928]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2013-14232]

-----------------------------------------------------------------------

ENVIRONMENTAL PROTECTION AGENCY

[EPA-HQ-OPPT-2009-0477; FRL-9375-8]

Endocrine Disruptor Screening Program; Final Second List of 
Chemicals and Substances for Tier 1 Screening

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: This document announces the final second list of 109 chemicals 
identified for Tier 1 screening under the Endocrine Disruptor Screening 
Program (EDSP). The EDSP is established under section 408(p) of the 
Federal Food, Drug, and Cosmetic Act (FFDCA), which requires EPA to 
develop a chemical screening program using appropriate validated test 
systems and other scientifically relevant information to determine 
whether certain substances may have hormonal effects.

FOR FURTHER INFORMATION CONTACT: For technical information contact: 
Hannah Holsinger, Office of Water, 1200 Pennsylvania Ave. NW., 
Washington, DC 20460-0001 (MC-4607M); telephone number: (202) 564-0403, 
email address: holsinger.hannah@epa.gov, or Pat West, Office of Science 
Coordination and Policy, Environmental Protection Agency, 1200 
Pennsylvania Ave. NW., Washington, DC 20460-0001 (MC-7201M); telephone 
number: (202) 564-1656, email address: west.pat@epa.gov.
    For general information contact: The TSCA-Hotline, ABVI-Goodwill, 
422 South Clinton Ave., Rochester, NY 14620; telephone number: (202) 
554-1404; email address: TSCA-Hotline@epa.gov.

SUPPLEMENTARY INFORMATION:

I. General Information

A. Does this action apply to me?

    You may be potentially affected by this action if you produce, 
manufacture, use, or import chemicals (including pesticide chemicals) 
that may be found in sources of drinking water; if you manufacture or 
import chemicals that degrade to chemicals found in sources of drinking 
water; or if you are, or may otherwise be, involved in the testing of 
chemicals for potential endocrine effects. The following list of North 
American Industrial Classification System (NAICS) codes is not intended 
to be exhaustive, but rather provides a guide to help readers determine 
whether this document applies to them. Potentially affected entities 
may include:
     Chemical manufacturers, importers and processors (NAICS 
code 325), e.g., persons who manufacture, import or process chemical 
substances.
     Pesticide, fertilizer, and other agricultural chemical 
manufacturers (NAICS code 3253), e.g., persons who manufacture, import 
or process pesticide, fertilizer and agricultural chemicals.
     Scientific research and development services (NAICS code 
5417), e.g., persons who conduct testing of chemical substances for 
endocrine effects.

B. How can I get copies of this document and other related information?

    The docket for this action, identified by docket identification 
(ID) number EPA-HQ-OPPT-2009-0477, is available at http://www.regulations.gov or at the Office of Pollution Prevention and Toxics 
Docket (OPPT Docket), Environmental Protection Agency Docket Center 
(EPA/DC), EPA West Bldg., Rm. 3334, 1301 Constitution Ave. NW., 
Washington, DC. The Public Reading Room is open from 8:30 a.m. to 4:30 
p.m., Monday through Friday, excluding legal holidays. The telephone 
number for the Public Reading Room is (202) 566-1744, and the telephone 
number for the OPPT Docket is (202) 566-0280. Please review the visitor 
instructions and additional information about the docket available at 
http://www.epa.gov/dockets.

II. Background

A. What action is the agency taking?

    This document announces the final second list of 109 chemicals 
identified for Tier 1 screening under the Endocrine Disruptor Screening 
Program (EDSP). The EDSP is established under section 408(p) of the 
Federal Food, Drug, and Cosmetic Act (FFDCA), which requires EPA to 
develop a chemical screening program using appropriate validated test 
systems and other scientifically relevant information to determine 
whether certain substances may have hormonal effects. After considering 
comments received on the draft second list of chemicals and substances 
published in the Federal Register notice of November 17, 2010 (75 FR 
70248) (FRL-8848-7) (Ref. 1), EPA is announcing the final list of the 
second group of chemicals that will be subject to screening based on 
the approach described in the notice--``Endocrine Disruptor Screening 
Program; Final Policies and Procedures for Screening Safe Drinking 
Water Act (SDWA) Chemicals,'' published elsewhere in today's Federal 
Register.
    The EDSP consists of a two-tiered approach to screen and test 
chemicals for potential endocrine disrupting effects. The purpose of 
Tier 1 screening is to identify substances that have the potential to 
interact with the endocrine system (specifically the estrogen, 
androgen, or thyroid hormone systems) using a battery of assays. 
Substances that have the potential to interact with estrogen, androgen 
or thyroid systems may proceed to Tier 2, which is designed to identify 
any adverse endocrine-related effects caused by the

[[Page 35923]]

substance, and establish a quantitative relationship between the dose 
and that endocrine effect. This second list should not be construed as 
a list of known or likely endocrine disruptors. Nothing in the approach 
for generating the second list provides a basis to infer that by simply 
being on this list these chemicals are suspected to interfere with the 
endocrine systems of humans or other species, and it would be 
inappropriate to do so. In a separate notice published elsewhere in 
today's Federal Register, EPA describes other aspects of EDSP such as 
the administrative procedures that EPA will use to require testing.
    The second group of chemicals to be tested consists of chemicals 
that section 408(p) of the FFDCA (Ref. 2) requires be screened, i.e., 
pesticide active ingredients and chemicals used as pesticide inert 
ingredients (also known as other ingredients) and section 1457 of the 
1996 amendment to the SDWA (Ref. 3). EPA developed this final list 
using the approach outlined in the Federal Register notice announcing 
the draft second list of chemicals and substances (Ref. 1). More 
information on EPA's priority setting approach is available at http://www.epa.gov/scipoly/oscpendo/pubs/prioritysetting.
    This document does not describe other aspects of EDSP such as the 
administrative procedures EPA generally intends to use to require 
testing, the validated tests and battery that will be included in EDSP, 
or the timeframe for requiring the testing or receiving the data. The 
administrative procedures that EPA generally intends to use are 
described in a separate notice published elsewhere in today's Federal 
Register. The remaining topics will be addressed in separate notices 
that will be subsequently published in the Federal Register.

B. What is the agency's authority for taking this action?

    FFDCA section 408(p) requires EPA to ``develop a screening program, 
using appropriate validated test systems and other scientifically 
relevant information, to determine whether certain substances may have 
an effect in humans that is similar to an effect produced by a 
naturally occurring estrogen, or such other endocrine effect as [EPA] 
may designate'' (21 U.S.C. 346a(p)). Section 408(p)(3) generally 
requires EPA to ``provide for the testing of all pesticide chemicals'' 
and gives EPA discretionary authority to ``provide for the testing of 
any other substance that may have an effect that is cumulative to an 
effect of a pesticide chemical if the Administrator determines that a 
substantial population may be exposed to such a substance'' (21 U.S.C. 
346a(p)(3)). The statute also authorizes EPA to exempt a chemical upon 
a determination that ``the substance is anticipated not to produce any 
effect in humans similar to an effect produced by a naturally occurring 
estrogen.'' (21 U.S.C. 346a(p)(4)).
    Section 1457 of SDWA states that ``in addition to the substances'' 
referred to in FFDCA section 408(p)(3)(B), ``the Administrator may 
provide for testing under the screening program authorized by section 
408(p) of such Act, in accordance with the provisions of section 408(p) 
of such Act, of any other substance that may be found in sources of 
drinking water if the Administrator determines that a substantial 
population may be exposed to such substance'' (42 U.S.C. 300j-17). EPA 
used its authority under SDWA to identify a portion of the chemicals on 
the second EDSP list.

III. History

    EPA developed EDSP in response to a Congressional mandate in FFDCA 
``to determine whether certain substances may have an effect in humans 
that is similar to an effect produced by a naturally occurring 
estrogen, or such other endocrine effect as [EPA] may designate'' (21 
U.S.C. 346a(p)). Unit II.B. describes the authority for listing a 
chemical. As part of EDSP, EPA issues orders to collect certain test 
data on selected chemical substances. In general, EPA intends to use 
the data collected under EDSP, along with other information, to 
determine if a pesticide chemical or other substances may pose a risk 
to human health or the environment due to disruption of the endocrine 
system. The determination that a chemical does or is not likely to have 
the potential to interact with the endocrine system will be made on a 
weight-of-evidence basis taking into account data from the Tier 1 
assays and/or other scientifically relevant information. Chemicals that 
go through Tier 1 screening and are found to have the potential to 
interact with the estrogen, androgen, or thyroid hormone systems will 
proceed to the next state of EDSP where EPA will determine which, if 
any, of the Tier 2 tests are necessary based on available data. Tier 2 
testing is designed to identify any adverse endocrine-related effects 
caused by the substance, and establish a quantitative relationship 
between the dose and that endocrine effect. Further information 
regarding EDSP and requirements for Tier 1 and Tier 2 testing can be 
found on the Agency's EDSP Web site, at http://www.epa.gov/endo/.

IV. Development of the Second EDSP List

    The House Appropriations Committee report for EPA's FY 2010 
appropriations (H.R. 2996, H. Rept. 111-180) (Ref. 4), directed EPA to 
publish within 1 year of enactment a second list of no less than 100 
chemicals for screening that includes drinking water contaminants, such 
as halogenated organic chemicals, dioxins, flame retardants 
polybrominated diphenyl ethers, polychlorinated biphenyls, 
perfluorocarbons (PFCs), plastics, bisphenol A, pharmaceuticals and 
personal care products, and issue 25 orders per year for the testing of 
these chemicals. This process also should allow for public input. In 
response, EPA published a draft second list of chemicals for Tier 1 
screening on November 17, 2010 and solicited public comments on the 
list of chemicals. The development of the draft second list is 
described at length in that Federal Register notice (Ref. 1).
    EPA received comment letters from approximately 60 organizations or 
individuals on the November 17, 2010 draft second EDSP list. These 
organizations/individuals included a water-related association, 
environmental advocacy groups, chemical industry, consumer and pet 
advocacy groups, and consultants writing on behalf of the industry. 
This notice summarizes major comments EPA received, along with the 
Agency's response. A complete listing of public comments and EPA's 
responses related to the draft second list of chemicals for Tier 1 
screening are included in the document entitled ``Final Comment 
Response Document for the Second Endocrine Disruptor Screening Program 
List (Categorized Public Comments).'' The document is available in the 
docket for this action under docket ID number EPA-HQ-OPPT-2009-0477.

A. SDWA 1457

    Some commenters stated that EPA had not met the requirements of 
SDWA 1457 when listing the draft second EDSP list. They stated that a 
chemical's inclusion on the third Contaminant Candidate List (CCL3) 
does not mean that the chemical meets SDWA 1457 requirements. SDWA 1457 
states that ``the Administrator may provide for testing under the 
screening program authorized by section 408(p) of such Act, . . . of 
any other substance that may be found in sources of drinking water if 
the Administrator determines that a substantial population may be 
exposed to such substance.'' SDWA section 1457 sets forth the criteria 
for

[[Page 35924]]

the selection of substances for EDSP. Section 1457 does not require the 
Agency to promulgate regulations further defining these criteria.
    For the EDSP, EPA selected contaminants from the CCL3, for which 
EPA had evaluated the nature of the occurrence and prevalence 
information (Ref. 5), and selected contaminants from National Primary 
Drinking Water Regulations (NPDWRs), which were designated by Congress 
for regulation due to concerns about occurrence in drinking water and 
adverse impacts on human health. The scientific basis for EPA's 
selection of contaminants on the CCL3 also provides the basis for EPA's 
determination that a chemical may be found in sources of drinking water 
to which a substantial population may be exposed for the purposes of 
SDWA section 1457.

B. Support for Contaminants Listed in the Draft Second List

    The Agency received comments supporting the contaminants included 
on the draft second EDSP list. One commenter stated that the draft 
second EDSP list was an appropriate starting point since it was 
developed from existing NPDWRs and the CCL3. Another commenter 
acknowledged that many of the chemicals included on the draft second 
EDSP list have already undergone a rigorous review within the Agency 
for exposure potential in vulnerable populations and noted there is 
incomplete toxicity data for the general population. The commenter 
stated that EDSP will contribute important information about endocrine 
disrupting potential of chemicals which have never been tested for 
sensitive endpoints in estrogen, androgen, and thyroid hormone 
disruption.

C. Exclusion or Inclusion of Contaminants

    EPA received comments concerning contaminants that are no longer 
manufactured or that have been cancelled (banned), indicating these 
should be removed from the list. EPA also received comments related to 
chemicals with physiochemical properties that would likely result in 
test assay incompatibility issues. EPA agrees that contaminants derived 
from chemicals that have been banned or are no longer manufactured 
should be removed from the list. EPA has generally determined that it 
would be reasonable to prioritize testing for those compounds which a 
manufacturer, importer, or registrant is clearly identifiable and the 
Agency could order these entities to conduct the testing. Chemicals 
that have been banned or are no longer manufactured (or imported) do 
not fit within this category. EPA also agrees that it would be 
reasonable to exclude chemicals from the second list based on the 
highly reactive physiochemical properties of the chemicals and test 
assay incompatibility issues. The exclusion rationales for streamlining 
the second EDSP list are discussed in the Federal Register notice for 
the draft second list (Ref. 1).
    Table 1 of this notice contains a list of chemicals that EPA 
believes should be removed from the final second list because they are 
no longer manufactured, are banned chemicals, or the chemicals have 
physiological properties that make them highly reactive and 
incompatible with the testing assays. Other chemicals remain on the 
list as they are still in use and may be found in sources of drinking 
water (see Unit IV.A. of this notice).
    Other comments EPA received stated those chemicals with a maximum 
contaminant level goal of zero should be removed. EPA recognizes that 
it may not be possible to set more stringent levels for some of these 
chemicals at this time. However, it is important to note that most of 
the chemicals with maximum contaminant level goals of zero are based on 
chronic health endpoints and compounds with endocrine disrupting 
effects that can be subchronic. Also, it would be important to 
understand whether a chemical might be an endocrine disruptor with 
subchronic impacts since this may inform the Agency's risk assessment 
and how best to address this contaminant from a regulatory standpoint. 
In addition, if endocrine effects occur at a level lower than the 
current maximum contaminant level, the Agency might consider whether 
improvements in analytical feasibility, which would allow measurements 
at the level of endocrine effects, have been developed since the 
promulgation of the existing MCLs.
    EPA also received comments stating that the Agency should have 
included some chemicals (e.g., triclosan, alkylphenols and alkylphenol 
polyethoxylates, bisphenol A, musk fragrances, and pharmaceutical 
estrogens) with known or suspected endocrine disrupting effects on the 
second list. When compiling the second EDSP list, EPA focused on 
priority drinking water contaminants and pesticides previously 
identified by EPA. These priority chemicals included the CCL3 
chemicals, chemicals with NPDWRs, and registration review pesticides. 
The basis for chemical selection is described in the Federal Register 
notice for the draft second list (Ref. 1). While the chemicals 
mentioned in the comments were not included on the current EDSP list, 
they may be included on future EDSP lists. Several of the chemicals 
suggested by commenters were evaluated as part of the CCL3 process but 
did not make the final CCL3 for reasons that are outlined in EPA 
supporting documents ``Final Contaminant Candidate List 3 Chemicals: 
Identifying the Universe, Final Contaminant Candidate List 3 Chemicals: 
Screening to a PCCL,'' and ``Final Contaminant Candidate List 3 
Chemicals: PCCL to CCL'' (Refs. 6, 7, and 8).
    As for the current approach for selecting chemicals for the second 
EDSP list, EPA excluded chemicals that are hormones with confirmed 
effects as stated in the Federal Register notice for the draft second 
list (Ref. 1). EPA did not give weight to information on the potential 
for a chemical to cause endocrine effects as criteria for listing as 
the purpose of the second EDSP list is to identify substances that have 
the potential to interact with the endocrine system using appropriate 
validated test systems and other scientifically relevant information. 
The final second EDSP list should neither be construed as a list of 
known or likely endocrine disruptors nor characterized as such.
    Some commenters also stated that naturally occurring contaminants 
should be excluded from the draft second EDSP list. EPA sought and used 
the best available information regarding all substances on the draft 
second EDSP list, including those that have the potential to naturally 
occur. Although EPA acknowledges that some substances on the list 
(e.g., acetaldehyde, acrylamide, methanol, and perchlorate) can occur 
naturally in the environment, this is not the only known pathway of 
occurrence for these chemicals to enter into the environment. A basis 
for chemical selection includes selecting substances that are known or 
anticipated to occur in public drinking water. Anthropogenic pathways 
for these chemicals to enter the environment are shown through data 
from the Toxic Release Inventory (TRI), Chemical Update System/
Inventory Update Rule (CUS/IUR), and chemical manufacturing 
information. Consequently, EPA does not believe that the fact that 
these chemicals can occur naturally is sufficient reason to exclude the 
manufacturers and importers of these chemicals from conducting the 
necessary testing.

D. Pesticide Registration Review Issues

    EPA received comments stating that pesticide active ingredients 
should not be included on EDSP list and suggesting

[[Page 35925]]

that issuance of test orders should align with pesticide registration 
review schedules.
    The Agency is working toward integrating EDSP and the Registration 
Review Program, such that the data gathering may be completed in a 
coordinated manner under these two programs to permit a timely 
registration review decision inclusive of EDSP and not rely on the 
fixed chemical list approach for active ingredients. Ultimately, EPA 
intends that chemicals scheduled for registration review may receive 
EDSP test orders and the data submitted in response to those orders are 
coordinated with the submission of data required under registration 
review. The Agency may then review and evaluate the data submitted for 
both programs in the same time frame, complete the risk assessment with 
EDSP outcomes as appropriate, and likely conclude registration review 
for a given chemical within the schedule, enhancing efficiency. 
Currently, however, EPA does not have an information collection request 
(ICR) clearance to issue orders to require EDSP testing generally for 
registration review chemicals. While the ICR clearance process 
continues, EPA continues to rely on the chemical list approach for the 
fiscal year 2007/2008 registration review chemicals in an attempt to 
begin to address EDSP testing for the early registration review 
chemicals.

V. The Final Second List of Chemicals and Substances for Tier 1 
Screening

A. Chemicals and Substances Removed From the Draft Second List for Tier 
1 Screening

    EPA removed 25 chemicals and substances from the draft second list 
based on two of the criteria published in the November 17, 2010 issue 
of the Federal Register, (Ref. 1):
    1. Chemicals for which the manufacturer, importer or registrant 
cannot be clearly identified (criterion two).
    2. Chemicals not likely to be biologically active or which are 
incompatible with testing assays for various reasons due to one or more 
of their physiochemical properties (criterion five).

EPA reevaluated the draft second list of chemicals and substances based 
on public comments and determined that sufficient data exist to remove 
a total of 25 additional contaminants based on criterion two (n=21) and 
criterion five (n=4). Table 1 presents an alphabetized list of 25 
chemicals and substances EPA removed from the original list of 134 
proposed for Tier 1 screening and provides the rationale for removal.
    Although these chemicals have been removed from the second group of 
chemicals and substances that EPA will screen, it is important to note 
that the removal of these chemicals and substances does not imply that 
the Agency has no interest in the potential for endocrine disruption 
activity for these contaminants. At this time the Agency realizes that 
there is some difficulty with collecting the information about 
endocrine effects through EDSP because of the Agency's inability to 
identify a manufacturer, importer, or registrant or because the 
contaminant is incompatible with the testing assays.

                             Table 1--Chemicals Removed From Draft Second EDSP List
----------------------------------------------------------------------------------------------------------------
          Chemical name               CAS Reg No.           SDWA             PAI                Rationale
----------------------------------------------------------------------------------------------------------------
1. 1, 2-Dibormo-3-chlorproprane              96-12-8               X   ...............  Pesticide not in use;
 (DBCP).                                                                                 TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
2. 2, 4, 5-TP (Silvex)...........            93-72-1               X   ...............  Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
3. Benzyl chloride...............           100-44-7               X   ...............  Physiochemical
                                                                                         properties--highly
                                                                                         reactive; incompatible
                                                                                         with the testing
                                                                                         assays.
4. Chlordane.....................            57-74-9               X   ...............  Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
5. Cumene hydroperoxide..........            80-15-9               X   ...............  Physiochemical
                                                                                         properties--highly
                                                                                         reactive; incompatible
                                                                                         with the testing
                                                                                         assays.
6. Dalapon.......................            75-99-0               X   ...............  Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
7. Dimethipin....................         55290-64-7               X   ...............  Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
8. Dinoseb.......................            88-85-7               X   ...............  Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
9. Endrin........................            72-20-8               X   ...............  Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
10. Ethylene dibromide (EDB).....           106-93-4               X   ...............  Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
11. Fenamiphos...................         22224-92-6               X                X   Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
12. Fenarimol....................         60168-88-9  ...............               X   Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
13. Fenoxycarb...................         72490-01-8  ...............               X   Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.

[[Page 35926]]

 
14. Heptachlor...................            76-44-8               X   ...............  Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
15. Heptachlor epoxide...........          1024-57-3               X   ...............  Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
16. Methoxychlor.................            72-43-5               X   ...............  Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
17. Molinate.....................          2212-67-1               X   ...............  Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
18. Oxirane, methyl-.............            75-56-9               X   ...............  Physiochemical
                                                                                         properties--highly
                                                                                         reactive; incompatible
                                                                                         with the testing
                                                                                         assays.
19. Propetamphos.................         31218-83-4  ...............               X   Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
20. Pyridate.....................         55512-33-9  ...............               X   Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
21. Sodium tetrathiocarbonate....          7345-69-9  ...............               X   Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
22. Sulfosate....................         81591-81-3  ...............               X   Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
23. Temephos.....................          3383-96-8  ...............               X   Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
24. Toxaphene....................          8001-35-2               X   ...............  Pesticide not in use;
                                                                                         TRI and/or IUR
                                                                                         indicates importers or
                                                                                         manufacturers are
                                                                                         unlikely.
25. Triethylamine................           121-44-8               X   ...............  Physiochemical
                                                                                         properties--highly
                                                                                         reactive; incompatible
                                                                                         with the testing
                                                                                         assays.
----------------------------------------------------------------------------------------------------------------
Endnotes--Table 1:
 TRI contains information on toxic chemical releases from facilities that meet reporting criteria (for
  most chemicals the thresholds are 25,000 pounds for manufacturing and processing and 10,000 pounds for use).
 IUR contains site and manufacturing information for chemicals manufactured (including imported) in
  amounts of 25,000 pounds or greater at a single site.

B. The Final Second List of Chemical and Substances for EDSP Tier 1 
Screening

    Table 2 presents an alphabetized list of the 109 chemicals and 
substances included in the final second EDSP list of chemicals for Tier 
1 screening. As in the draft second list, the final list includes 
pesticides, two PFCs, and three pharmaceuticals (erythromycin, 
nitroglycerin, and quinoline). The list also consists of an array of 
other chemicals ranging from those used for industrial manufacturing 
processes, as plasticizers, or in the production of pharmaceutical, 
personal care products, and toxic substances. Because this list of 
chemicals was selected on the basis of exposure potential only, it 
should neither be construed as a list of known or likely endocrine 
disruptors nor characterized as such.

                        Table 2--Final Second EDSP List of Chemicals for Tier 1 Screening
----------------------------------------------------------------------------------------------------------------
                       Chemical name                            CAS Reg No.           SDWA             PAI
----------------------------------------------------------------------------------------------------------------
1. 1,1,1,2-Tetrachloroethane...............................           630-20-6               X   ...............
2. 1,1,1-Trichloroethane...................................            71-55-6               X   ...............
3. 1,1,2-Trichloroethane...................................            79-00-5               X   ...............
4. 1,1-Dichloroethane......................................            75-34-3               X   ...............
5. 1,1-Dichloroethylene....................................            75-35-4               X   ...............
6. 1,2,3-Trichloropropane..................................            96-18-4               X   ...............
7. 1,2,4-Trichlorobenzene..................................           120-82-1               X   ...............
8. 1,2-Dichloroethane......................................           107-06-2               X   ...............
9. 1,2-Dichloropropane.....................................            78-87-5               X   ...............
10. 1,3-Dinitrobenzene.....................................            99-65-0               X   ...............
11. 1,4-Dioxane............................................           123-91-1               X   ...............
12. 1-Butanol..............................................            71-36-3               X   ...............
13. 2-Methoxyethanol.......................................           109-86-4               X   ...............
14. 2-Propen-1-ol..........................................           107-18-6               X   ...............
15. 4,4'-Methylenedianiline................................           101-77-9               X   ...............
16. Acetaldehyde...........................................            75-07-0               X   ...............

[[Page 35927]]

 
17. Acetamide..............................................            60-35-5               X   ...............
18. Acetochlor.............................................         34256-82-1               X                X
19. Acetochlor ethanesulfonic acid (ESA)...................        187022-11-3               X   ...............
20. Acetochlor oxanilic acid (OA)..........................        194992-44-4               X   ...............
21. Acrolein...............................................           107-02-8               X                X
22. Acrylamide.............................................            79-06-1               X   ...............
23. Alachlor...............................................         15972-60-8               X                X
24. Alachlor ethanesulfonic acid (ESA).....................        142363-53-9               X   ...............
25. Alachlor oxanilic acid (OA)............................        171262-17-2               X   ...............
26. alpha-Hexachlorocyclohexane............................           319-84-6               X   ...............
27. Aniline................................................            62-53-3               X   ...............
28. Bensulide..............................................           741-58-2               X                X
29. Benzene................................................            71-43-2               X   ...............
30. Benzo(a)pyrene (PAHs)..................................            50-32-8               X   ...............
31. Butylated hydroxyanisole...............................         25013-16-5               X   ...............
32. Carbon tetrachloride...................................            56-23-5               X   ...............
33. Chlorobenzene..........................................           108-90-7               X   ...............
34. cis-1,2-Dichloroethylene...............................           156-59-2               X   ...............
35. Clethodim..............................................         99129-21-2               X                X
36. Clofentezine...........................................         74115-24-5  ...............               X
37. Clomazone..............................................         81777-89-1  ...............               X
38. Coumaphos..............................................            56-72-4  ...............               X
39. Cyanamide..............................................           420-04-2  ...............               X
40. Cyromazine.............................................         66215-27-8  ...............               X
41. Denatonium saccharide..................................         90823-38-4  ...............               X
42. Di(2-ethylhexyl) adipate...............................           103-23-1               X   ...............
43. Dichloromethane........................................            75-09-2               X   ...............
44. Dicrotophos............................................           141-66-2               X                X
45. Diuron.................................................           330-54-1               X                X
46. Endothall..............................................           145-73-3               X                X
47. Epichlorohydrin........................................           106-89-8               X   ...............
48. Erythromycin...........................................           114-07-8               X   ...............
49. Ethylbenzene...........................................           100-41-4               X   ...............
50. Ethylene glycol........................................           107-21-1               X   ...............
51. Ethylene thiourea......................................            96-45-7               X   ...............
52. Ethylurethane..........................................            51-79-6               X   ...............
53. Etofenprox.............................................         80844-07-1  ...............               X
54. Fenoxaprop-P-ethyl.....................................         71283-80-2  ...............               X
55. Flumetsulam............................................         98967-40-9  ...............               X
56. Fomesafen sodium.......................................        108731-70-0  ...............               X
57. Fosetyl-Al (Aliette)...................................         39148-24-8  ...............               X
58. Glufosinate ammonium...................................         77182-82-2  ...............               X
59. HCFC-22................................................            75-45-6               X   ...............
60. Hexachlorobenzene......................................           118-74-1               X   ...............
61. Hexachlorocyclopentadiene..............................            77-47-4               X   ...............
62. Hexane.................................................           110-54-3               X   ...............
63. Hexythiazox............................................         78587-05-0  ...............               X
64. Hydrazine..............................................           302-01-2               X   ...............
65. Isoxaben...............................................         82558-50-7  ...............               X
66. Lactofen...............................................         77501-63-4  ...............               X
67. Lindane................................................            58-89-9               X   ...............
68. Methanol...............................................            67-56-1               X   ...............
69. Methyl tert-butyl ether................................          1634-04-4               X   ...............
70. Metolachlor ethanesulfonic acid (ESA)..................        171118-09-5               X   ...............
71. Metolachlor oxanilic acid (OA).........................        152019-73-3               X   ...............
72. Nitrobenzene...........................................            98-95-3               X   ...............
73. Nitroglycerin..........................................            55-63-0               X   ...............
74. N-Methyl-2-pyrrolidone.................................           872-50-4               X   ...............
75. N-Nitrosodimethylamine (NDMA)..........................            62-75-9               X   ...............
76. n-Propylbenzene........................................           103-65-1               X   ...............
77. o-Dichlorobenzene......................................            95-50-1               X   ...............
78. o-Toluidine............................................            95-53-4               X   ...............
79. Oxydemeton-methyl......................................           301-12-2               X                X
80. Oxyfluorfen............................................         42874-03-3               X                X
81. Paclobutrazol..........................................         76738-62-0  ...............               X
82. p-Dichlorobenzene......................................           106-46-7               X                X
83. Pentachlorophenol......................................            87-86-5               X                X
84. Perchlorate............................................         14797-73-0               X   ...............
85. Perfluorooctane sulfonic acid (PFOS)...................          1763-23-1               X   ...............
86. Perfluorooctanoic acid (PFOA)..........................           335-67-1               X   ...............
87. Picloram...............................................          1918-02-1               X                X
88. Polychlorinated biphenyls..............................          1336-36-3               X   ...............

[[Page 35928]]

 
89. Profenofos.............................................         41198-08-7               X                X
90. Propionic acid.........................................            79-09-4  ...............               X
91. Quinclorac.............................................         84087-01-4  ...............               X
92. Quinoline..............................................            91-22-5               X   ...............
93. Quizalofop-P-ethyl.....................................        100646-51-3  ...............               X
94. RDX....................................................           121-82-4               X   ...............
95. sec-Butylbenzene.......................................           135-98-8               X   ...............
96. Styrene................................................           100-42-5               X   ...............
97. Terbufos...............................................         13071-79-9               X                X
98. Terbufos sulfone.......................................         56070-16-7               X   ...............
99. Tetrachloroethylene....................................           127-18-4               X   ...............
100. Thiophanate-methyl....................................         23564-05-8               X                X
101. Toluene diisocyanate..................................         26471-62-5               X   ...............
102. trans-1,2-Dichloroethylene............................           156-60-5               X   ...............
103. Trichloroethylene.....................................            79-01-6               X   ...............
104. Triflumizole..........................................         68694-11-1  ...............               X
105. Trinexapac-ethyl......................................         95266-40-3  ...............               X
106. Triphenyltin hydroxide (TPTH).........................            76-87-9               X                X
107. Vinclozolin...........................................         50471-44-8               X                X
108. Xylenes (total).......................................          1330-20-7               X                X
109. Ziram.................................................           137-30-4               X                X
                                                            ----------------------------------------------------
    Total.....................................................................              88               41
----------------------------------------------------------------------------------------------------------------

VI. References

    The following is a list of the documents that are specifically 
referenced in this document. These references are available at http://www.regulations.gov.

1. USEPA. 2010. Endocrine Disruptor Screening Program; Second List 
of Chemicals for Tier 1 Screening; Notice. Federal Register, 75 FR 
70248, November 17, 2010.
2. USEPA. 1996. FFDCA section 408(p). Available on-line at http://epw.senate.gov/FDA_001.pdf.
3. USEPA. 1996. Amendments to the Safe Drinking Water Act. Available 
on-line at: http://water.epa.gov/lawsregs/guidance/sdwa/text.cfm.
4. U.S. Congress. House Report 111-180. Available at: http://www.gpo.gov/fdsys/pkg/CRPT-111hrpt180/pdf/CRPT-111hrpt180.pdf.
5. USEPA. 2009. Drinking Water Contaminant Candidate List 3--Final; 
Notice. Federal Register. Vol. 74. No 194. p. 51850. October 8, 
2009.
6. USEPA. 2009. Final Contaminant Candidate List 3 Chemicals: 
Identifying the Universe, EPA 815-R-09-006. August 2009.
7. USEPA. 2009. Final Contaminant Candidate List 3 Chemicals: 
Screening to a PCCL, EPA 815-R-05-007. August, 2009.
8. USEPA. 2009. Final Contaminant Candidate List 3 Chemicals: 
Classification of the PCCL to the CCL, EPA 815-R-09-008. August, 
2009.

List of Subjects

    Environmental protection, Chemicals, Drinking water, Endocrine 
disruptors, Pesticides.

    Dated: May 29, 2013.
James Jones,
Acting Assistant Administrator, Office of Chemical Safety and Pollution 
Prevention.
[FR Doc. 2013-14232 Filed 6-13-13; 8:45 am]
BILLING CODE 6560-50-P