Document ID: EPA-HQ-OPP-2003-0071-0001
Agency: epa
Document Type: Notice
Title: Quinoxyfen; Notice of Filing a Pesticide Petition to Establish a Tolerance for a Certain Pesticide Chemical in or on Food
Posted Date: 2003-05-30T04:00Z

32497
Federal
Register
/
Vol.
68,
No.
104
/
Friday,
May
30,
2003
/
Notices
June
30,
2004.
The
Agency
intends
to
announce
this
in
a
cancellation
order
following
the
comment
period,
unless
substantive
comments
warrant
the
Agency's
further
review
of
this
request.
Use
of
fenthion
will
be
prohibited
after
November
30,
2004.
All
unopened
material
may
be
returned
to
Bayer
Environmental
Science
until
December
31,
2004.
B.
Requests
for
Voluntary
Cancellation
Under
section
6(
f)(
1)(
A)
of
FIFRA,
registrants
may
request,
at
any
time,
that
their
pesticide
registrations
be
canceled
or
amended
to
terminate
one
or
more
pesticide
uses.
Section
6(
f)(
1)(
B)
of
FIFRA
requires
that
before
acting
on
a
request
for
voluntary
cancellation,
EPA
must
provide
a
30
 
day
public
comment
period
on
the
request
for
voluntary
cancellation.
In
addition,
section
6(
f)(
1)(
C)
of
FIFRA
requires
that
EPA
provide
a
60
 
day
comment
period
on
a
request
for
voluntary
termination
of
any
minor
agricultural
use
before
granting
the
request,
unless:
(
1)
The
registrants
request
a
waiver
of
the
comment
period,
or
(
2)
the
Administrator
determines
that
continued
use
of
the
pesticide
would
pose
an
unreasonable
adverse
effect
on
the
environment.
The
registant
has
requested
a
waiver
of
the
comment
period.
The
Agency
will
therefore
apply
a
60
 
day
comment
period.

TABLE
1.
 
REGISTRATIONS
WITH
PENDING
REQUESTS
FOR
CANCELLATION
Registration
No.
Product
Name
Company
432
 
1285
Baytex
Liquid
Concentrate
Insecticide
Bayer
Environmental
Science
432
 
1290
Baytex
Technical
Insecticide
Bayer
Environmental
Science
Unless
a
request
is
withdrawn
by
the
registrant
within
60
days
of
publication
of
this
notice,
or
if
the
Agency
determines
that
there
are
substantive
comments
that
warrant
further
review
of
this
request,
an
order
will
be
issued
canceling
all
of
these
registrations.
Table
2
of
this
unit
includes
the
name
and
address
of
record
for
the
registrant
of
the
products
in
Table
1
of
this
unit.

TABLE
2.
 
REGISTRANTS
REQUESTING
VOLUNTARY
CANCELLATION
EPA
Company
No.
Company
Name
and
Address
432
Bayer
Environmental
Science,
95
Chestnut
Ridge
Road,
Montvale,
NJ
07645
III.
What
is
the
Agency's
Authority
for
Taking
this
Action?

Section
6(
f)(
1)
of
FIFRA
provides
that
a
registrant
of
a
pesticide
product
may
at
any
time
request
that
any
of
its
pesticide
registrations
be
canceled.
FIFRA
further
provides
that,
before
acting
on
the
request,
EPA
must
publish
a
notice
of
receipt
of
any
such
request
in
the
Federal
Register
and
must
accept
public
comment
for
a
specified
time.
Thereafter,
the
Administrator
may
approve
such
a
request.

IV.
Procedures
for
Withdrawal
of
Request
and
Considerations
for
Reregistration
of
Fenthion
Registrants
who
choose
to
withdraw
a
request
for
cancellation
must
submit
such
withdrawal
in
writing
to
the
person
listed
under
FOR
FURTHER
INFORMATION
CONTACT,
postmarked
before
July
29,
2003.
This
written
withdrawal
of
the
request
for
cancellation
will
apply
only
to
the
applicable
FIFRA
section
6(
f)(
1)
request
listed
in
this
notice.
If
the
product(
s)
have
been
subject
to
a
previous
cancellation
action,
the
effective
date
of
cancellation
and
all
other
provisions
of
any
earlier
cancellation
action
are
controlling.
Any
person,
including
the
registrant,
who
wishes
to
support
the
continued
registration
of
fenthion,
must
fulfill
all
outstanding
data
gaps.
In
addition,
EPA
must
find
that
fenthion
is
eligible
for
reregistration.
Finally,
EPA
may
have
to
consult
with
the
U.
S.
Fish
and
Wildlife
Service
under
the
Endangered
Species
Act.

V.
Provisions
for
Disposition
of
Existing
Stocks
The
Agency
intends
to
issue
a
cancellation
order
following
consideration
of
all
comments
received
during
the
comment
period,
unless
the
comments
warrant
further
review
of
this
request.
Any
cancellation
order
issued
in
response
to
this
request
will
have
an
expected
effective
date
of
June
30,
2004.
Existing
stocks
are
those
stocks
of
registered
pesticide
products
which
are
currently
in
the
United
States
and
which
have
been
packaged,
labeled,
and
released
for
shipment
prior
to
the
effective
date
of
the
cancellation
action.
The
Agency
intends
to
grant
the
request
of
Bayer
that
there
be
no
distribution
and
sale
of
existing
stocks
as
of
the
effective
date
of
the
cancellation
order,
June
30,
2004,
except
for
the
return
to
Bayer
of
unused
product
or
for
proper
disposal
until
December
31,
2004.
The
Agency
also
intends
to
grant
Bayer's
request
that
the
use
of
fenthion
be
prohibited
as
of
November
30,
2004.
All
use
of
fenthion
must
be
in
accordance
with
the
terms
and
conditions
of
the
product's
labeling.
List
of
Subjects
Environmental
protection,
Pesticides
and
pests.

Dated:
April
29,
2003.
Lois
Ann
Rossi,
Director,
Special
Review
and
Reregistration
Division
[
FR
Doc.
03
 
13561
Filed
5
 
29
 
03;
8:
45
am]

BILLING
CODE
6560
 
50
 
S
ENVIRONMENTAL
PROTECTION
AGENCY
[
OPP
 
2003
 
0071;
FRL
 
7295
 
7]

Quinoxyfen;
Notice
of
Filing
a
Pesticide
Petition
to
Establish
a
Tolerance
for
a
Certain
Pesticide
Chemical
in
or
on
Food
AGENCY:
Environmental
Protection
Agency
(
EPA).
ACTION:
Notice.

SUMMARY:
This
notice
announces
the
initial
filing
of
a
pesticide
petition
proposing
the
establishment
of
regulations
for
residues
of
a
certain
pesticide
chemical
in
or
on
various
food
commodities.
DATES:
Comments,
identified
by
docket
ID
number
OPP
 
2003
 
0071,
must
be
received
on
or
before
June
30,
2003.
ADDRESSES:
Comments
may
be
submitted
electronically,
by
mail,
or
through
hand
delivery/
courier.
Follow
the
detailed
instructions
as
provided
in
Unit
I.
of
the
SUPPLEMENTARY
INFORMATION.

FOR
FURTHER
INFORMATION
CONTACT:
Shaja
R.
Brothers,
Registration
Division
(
7505C),
Office
of
Pesticide
Programs,
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460
 
0001;
telephone
number:

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Federal
Register
/
Vol.
68,
No.
104
/
Friday,
May
30,
2003
/
Notices
(
703)
308
 
3194];
e­
mail
address:
brothers.
shaja@
epa.
gov.

SUPPLEMENTARY
INFORMATION:

I.
General
Information
A.
Does
this
Action
Apply
to
Me?

You
may
be
potentially
affected
by
this
action
if
you
are
an
agricultural
producer,
food
manufacturer,
or
pesticide
manufacturer.
Potentially
affected
entities
may
include,
but
are
not
limited
to:
 
Crop
production
(
NAICS
111)
 
Animal
production
(
NAICS
112)
 
Food
manufacturing
(
NAICS
311)
 
Pesticide
manufacturing
(
NAICS
32532)
This
listing
is
not
intended
to
be
exhaustive,
but
rather
provides
a
guide
for
readers
regarding
entities
likely
to
be
affected
by
this
action.
Other
types
of
entities
not
listed
in
this
unit
could
also
be
affected.
The
North
American
Industrial
Classification
System
(
NAICS)
codes
have
been
provided
to
assist
you
and
others
in
determining
whether
this
action
might
apply
to
certain
entities.
If
you
have
any
questions
regarding
the
applicability
of
this
action
to
a
particular
entity,
consult
the
person
listed
under
FOR
FURTHER
INFORMATION
CONTACT.

B.
How
Can
I
Get
Copies
of
this
Document
and
Other
Related
Information?

1.
Docket.
EPA
has
established
an
official
public
docket
for
this
action
under
docket
ID
number
OPP
 
2003
 
0071.
The
official
public
docket
consists
of
the
documents
specifically
referenced
in
this
action,
any
public
comments
received,
and
other
information
related
to
this
action.
Although,
a
part
of
the
official
docket,
the
public
docket
does
not
include
Confidential
Business
Information
(
CBI)
or
other
information
whose
disclosure
is
restricted
by
statute.
The
official
public
docket
is
the
collection
of
materials
that
is
available
for
public
viewing
at
the
Public
Information
and
Records
Integrity
Branch
(
PIRIB),
Rm.
119,
Crystal
Mall
#
2,
1921
Jefferson
Davis
Hwy.,
Arlington,
VA.
This
docket
facility
is
open
from
8:
30
a.
m.
to
4
p.
m.,
Monday
through
Friday,
excluding
legal
holidays.
The
docket
telephone
number
is
(
703)
305
 
5805.
2.
Electronic
access.
You
may
access
this
Federal
Register
document
electronically
through
the
EPA
Internet
under
the
``
Federal
Register''
listings
at
http://
www.
epa.
gov/
fedrgstr/.
An
electronic
version
of
the
public
docket
is
available
through
EPA's
electronic
public
docket
and
comment
system,
EPA
Dockets.
You
may
use
EPA
Dockets
at
http://
www.
epa.
gov/
edocket/
to
submit
or
view
public
comments,
access
the
index
listing
of
the
contents
of
the
official
public
docket,
and
to
access
those
documents
in
the
public
docket
that
are
available
electronically.
Although,
not
all
docket
materials
may
be
available
electronically,
you
may
still
access
any
of
the
publicly
available
docket
materials
through
the
docket
facility
identified
in
Unit
I.
B.
1.
Once
in
the
system,
select
``
search,''
then
key
in
the
appropriate
docket
ID
number.
Certain
types
of
information
will
not
be
placed
in
the
EPA
dockets.
Information
claimed
as
CBI
and
other
information
whose
disclosure
is
restricted
by
statute,
which
is
not
included
in
the
official
public
docket,
will
not
be
available
for
public
viewing
in
EPA's
electronic
public
docket.
EPA's
policy
is
that
copyrighted
material
will
not
be
placed
in
EPA's
electronic
public
docket
but
will
be
available
only
in
printed,
paper
form
in
the
official
public
docket.
To
the
extent
feasible,
publicly
available
docket
materials
will
be
made
available
in
EPA's
electronic
public
docket.
When
a
document
is
selected
from
the
index
list
in
EPA
dockets,
the
system
will
identify
whether
the
document
is
available
for
viewing
in
EPA's
electronic
public
docket.
Although,
not
all
docket
materials
may
be
available
electronically,
you
may
still
access
any
of
the
publicly
available
docket
materials
through
the
docket
facility
identified
in
Unit
I.
B.
EPA
intends
to
work
towards
providing
electronic
access
to
all
of
the
publicly
available
docket
materials
through
EPA's
electronic
public
docket.
For
public
commenters,
it
is
important
to
note
that
EPA's
policy
is
that
public
comments,
whether
submitted
electronically
or
on
paper,
will
be
made
available
for
public
viewing
in
EPA's
electronic
public
docket
as
EPA
receives
them
and
without
change,
unless
the
comment
contains
copyrighted
material,
CBI,
or
other
information
whose
disclosure
is
restricted
by
statute.
When
EPA
identifies
a
comment
containing
copyrighted
material,
EPA
will
provide
a
reference
to
that
material
in
the
version
of
the
comment
that
is
placed
in
EPA's
electronic
public
docket.
The
entire
printed
comment,
including
the
copyrighted
material,
will
be
available
in
the
public
docket.
Public
comments
submitted
on
computer
disks
that
are
mailed
or
delivered
to
the
docket
will
be
transferred
to
EPA's
electronic
public
docket.
Public
comments
that
are
mailed
or
delivered
to
the
docket
will
be
scanned
and
placed
in
EPA's
electronic
public
docket.
Where
practical,
physical
objects
will
be
photographed,
and
the
photograph
will
be
placed
in
EPA's
electronic
public
docket
along
with
a
brief
description
written
by
the
docket
staff.

C.
How
and
to
Whom
Do
I
Submit
Comments?

You
may
submit
comments
electronically,
by
mail,
or
through
hand
delivery/
courier.
To
ensure
proper
receipt
by
EPA,
identify
the
appropriate
docket
ID
number
in
the
subject
line
on
the
first
page
of
your
comment.
Please
ensure
that
your
comments
are
submitted
within
the
specified
comment
period.
Comments
received
after
the
close
of
the
comment
period
will
be
marked
``
late.''
EPA
is
not
required
to
consider
these
late
comments.
If
you
wish
to
submit
CBI
or
information
that
is
otherwise
protected
by
statute,
please
follow
the
instructions
in
Unit
I.
D.
Do
not
use
EPA
dockets
or
e­
mail
to
submit
CBI
or
information
protected
by
statute.
1.
Electronically.
If
you
submit
an
electronic
comment
as
prescribed
in
this
unit,
EPA
recommends
that
you
include
your
name,
mailing
address,
and
an
email
address
or
other
contact
information
in
the
body
of
your
comment.
Also,
include
this
contact
information
on
the
outside
of
any
disk
or
CD
ROM
you
submit,
and
in
any
cover
letter
accompanying
the
disk
or
CD
ROM.
This
ensures
that
you
can
be
identified
as
the
submitter
of
the
comment
and
allows
EPA
to
contact
you
in
case
EPA
cannot
read
your
comment
due
to
technical
difficulties
or
needs
further
information
on
the
substance
of
your
comment.
EPA's
policy
is
that
EPA
will
not
edit
your
comment,
and
any
identifying
or
contact
information
provided
in
the
body
of
a
comment
will
be
included
as
part
of
the
comment
that
is
placed
in
the
official
public
docket,
and
made
available
in
EPA's
electronic
public
docket.
If
EPA
cannot
read
your
comment
due
to
technical
difficulties
and
cannot
contact
you
for
clarification,
EPA
may
not
be
able
to
consider
your
comment.
i.
EPA
Dockets.
Your
use
of
EPA's
electronic
public
docket
to
submit
comments
to
EPA
electronically
is
EPA's
preferred
method
for
receiving
comments.
Go
directly
to
EPA
Dockets
at
http://
www.
epa.
gov/
edocket,
and
follow
the
online
instructions
for
submitting
comments.
Once
in
the
system,
select
``
search,''
and
then
key
in
docket
ID
number
OPP
 
2003
 
0071.
The
system
is
an
``
anonymous
access''
system,
which
means
EPA
will
not
know
your
identity,
e­
mail
address
or
other
contact
information
unless
you
provide
it
in
the
body
of
your
comment.

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/
Vol.
68,
No.
104
/
Friday,
May
30,
2003
/
Notices
ii.
E­
mail.
Comments
may
be
sent
by
e­
mail
to
opp­
docket@
epa.
gov,
Attention:
Docket
ID
number
OPP
 
2003
 
0071.
In
contrast
to
EPA's
electronic
public
docket,
EPA's
e­
mail
system
is
not
an
``
anonymous
access''
system.
If
you
send
an
e­
mail
comment
directly
to
the
docket
without
going
through
EPA's
electronic
public
docket,
EPA's
e­
mail
system
automatically
captures
your
e­
mail
address.
E­
mail
addresses
that
are
automatically
captured
by
EPA's
e­
mail
system
are
included
as
part
of
the
comment
that
is
placed
in
the
official
public
docket,
and
made
available
in
EPA's
electronic
public
docket.
iii.
Disk
or
CD
ROM.
You
may
submit
comments
on
a
disk
or
CD
ROM
that
you
mail
to
the
mailing
address
identified
in
Unit
I.
C.
2.
These
electronic
submissions
will
be
accepted
in
WordPerfect
or
ASCII
file
format.
Avoid
the
use
of
special
characters
and
any
form
of
encryption.
2.
By
mail.
Send
your
comments
to:
Public
Information
and
Records
Integrity
Branch
(
PIRIB)
(
7502C),
Office
of
Pesticide
Programs
(
OPP),
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460
 
0001,
Attention:
Docket
ID
number
OPP
 
2003
 
0071.
3.
By
hand
delivery
or
courier.
Deliver
your
comments
to:
Public
Information
and
Records
Integrity
Branch
(
PIRIB),
Office
of
Pesticide
Programs
(
OPP),
Environmental
Protection
Agency,
Rm.
119,
Crystal
Mall
#
2,
1921
Jefferson
Davis
Hwy.,
Arlington,
VA,
Attention:
Docket
ID
number
OPP
 
2003
 
0071.
Such
deliveries
are
only
accepted
during
the
docket's
normal
hours
of
operation
as
identified
in
Unit
I.
B.
1.

D.
How
Should
I
Submit
CBI
to
the
Agency?
Do
not
submit
information
that
you
consider
to
be
CBI
electronically
through
EPA's
electronic
public
docket
or
by
e­
mail.
You
may
claim
information
that
you
submit
to
EPA
as
CBI
by
marking
any
part
or
all
of
that
information
as
CBI
(
if
you
submit
CBI
on
disk
or
CD
ROM,
mark
the
outside
of
the
disk
or
CD
ROM
as
CBI
and
then
identify
electronically
within
the
disk
or
CD
ROM
the
specific
information
that
is
CBI).
Information
so
marked
will
not
be
disclosed
except
in
accordance
with
procedures
set
forth
in
40
CFR
part
2.
In
addition
to
one
complete
version
of
the
comment
that
includes
any
information
claimed
as
CBI,
a
copy
of
the
comment
that
does
not
contain
the
information
claimed
as
CBI
must
be
submitted
for
inclusion
in
the
public
docket
and
EPA's
electronic
public
docket.
If
you
submit
the
copy
that
does
not
contain
CBI
on
disk
or
CD
ROM,
mark
the
outside
of
the
disk
or
CD
ROM
clearly
that
it
does
not
contain
CBI.
Information
not
marked
as
CBI
will
be
included
in
the
public
docket,
and
EPA's
electronic
public
docket
without
prior
notice.
If
you
have
any
questions
about
CBI,
or
the
procedures
for
claiming
CBI,
please
consult
the
person
listed
under
FOR
FURTHER
INFORMATION
CONTACT.

E.
What
Should
I
Consider
as
I
Prepare
My
Comments
for
EPA?

You
may
find
the
following
suggestions
helpful
for
preparing
your
comments:
1.
Explain
your
views
as
clearly
as
possible.
2.
Describe
any
assumptions
that
you
used.
3.
Provide
copies
of
any
technical
information
and/
or
data
you
used
that
support
your
views.
4.
If
you
estimate
potential
burden
or
costs,
explain
how
you
arrived
at
the
estimate
that
you
provide.
5.
Provide
specific
examples
to
illustrate
your
concerns.
6.
Make
sure
to
submit
your
comments
by
the
deadline
in
this
notice.
7.
To
ensure
proper
receipt
by
EPA,
be
sure
to
identify
the
docket
ID
number
assigned
to
this
action
in
the
subject
line
on
the
first
page
of
your
response.
You
may
also
provide
the
name,
date,
and
Federal
Register
citation.

II.
What
Action
is
the
Agency
Taking?

EPA
has
received
a
pesticide
petition
as
follows,
proposing
the
establishment
and/
or
amendment
of
regulations
for
residues
of
a
certain
pesticide
chemical
in
or
on
various
food
commodities
under
section
408
of
the
Federal
Food,
Drug,
and
Cosmetic
Act
(
FFDCA),
21
U.
S.
C.
346a.
EPA
has
determined
that
this
petition
contains
data
or
information
regarding
the
elements
set
forth
in
FFDCA
section
408(
d)(
2);
however,
EPA
has
not
fully
evaluated
the
sufficiency
of
the
submitted
data
at
this
time
or
whether
the
data
support
granting
of
the
petition.
Additional
data
may
be
needed
before
EPA
rules
on
the
petition.

List
of
Subjects
Environmental
protection,
Agricultural
commodities,
Feed
additives,
Food
additives,
Pesticides
and
pests,
Reporting
and
recordkeeping
requirements.
Dated:
May
19,
2003.
Peter
Caulkins,
Acting
Director,
Registration
Division,
Office
of
Pesticide
Programs.

Summary
of
Petitions
The
petitioner
summary
of
the
pesticide
petitions
is
printed
below
as
required
by
FFDCA
section
408(
d)(
3).
The
summary
of
the
petition
was
prepared
by
the
Interregional
Research
Project
Number
(
IR­
4),
and
represents
the
view
of
the
petitioner.
The
petition
summary
announces
the
availability
of
a
description
of
the
analytical
methods
available
to
EPA
for
the
detection
and
measurement
of
the
pesticide
chemical
residues
or
an
explanation
of
why
no
such
method
is
needed.

Interregional
Research
Project
Number
(
IR­
4)

PP
1E6302
and
2E6474
EPA
has
received
pesticide
petitions
(
1E6302
and
2E6474)
from
the
Interregional
Research
Project
Number
(
IR­
4),
681
U.
S.
Highway
#
1
South,
North
Brunswick,
NJ
08902
proposing,
pursuant
to
section
408(
d)
of
the
FFDCA,
21
U.
S.
C.
346a(
d),
to
amend
40
CFR
part
180
by
establishing
tolerances
for
residues
of
quinoxyfen
5,7­
dichloro­
4­
quinolyl
4­
fluorophenyl
ether
in
or
on
the
following
raw
agricultural
commodities:
Grape
at
0.70
parts
per
million
(
ppm)
(
1E6302),
hop,
dried
at
5
ppm
(
1E6302),
and
cherry
at
0.4
ppm
(
2E6474).
EPA
has
determined
that
the
petitions
contain
data
or
information
regarding
the
elements
set
forth
in
section
408(
d)(
2)
of
the
FFDCA;
however,
EPA
has
not
fully
evaluated
the
sufficiency
of
the
submitted
data
at
this
time
or
whether
the
data
support
granting
of
the
petitions.
Additional
data
may
be
needed
before
EPA
rules
on
the
petitions.
This
notice
includes
a
summary
of
the
petitions
prepared
by
the
registrant,
Dow
AgroSciences
LLC,
Indianapolis,
IN
46268.

A.
Residue
Chemistry
1.
Plant
metabolism.
The
nature
of
residues
is
adequately
understood
for
the
purposes
of
these
tolerances.
Based
on
the
findings
from
these
studies,
quinoxyfen
is
the
primary
residue
in
all
crops
and
therefore,
the
only
residue
of
concern.
Metabolites
were
present
at
low
levels
(<
10%
of
total
radioactive
residue).
Grape
vineyard,
cherry
orchards,
and
hops
are
not
normally
rotated
to
succeeding
crops,
therefore,
concerns
on
the
residues
in
rotational
crops
are
minimal.
Nonetheless,
a
confined
rotational
crop
study
was
conducted
with
quinoxyfen
which
confirmed
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minimal
carryover
of
residues
(>
0.003
µ
ug/
g)
to
succeeding
crops.
2.
Analytical
method.
A
practical
analytical
method
for
detecting
and
measuring
levels
of
quinoxyfen
in
or
on
cherries,
hops,
grapes
and
its
products
allows
monitoring
of
residues
at
or
above
the
tolerances
set
for
these
crops.
The
analytical
method
uses
capillary
gas
chromatography
and
mass
selective
detection
(
GC­
MSD)
with
limits
of
quantitation
(
LOQ)
of
0.01
parts
per
million
(
ppm)
for
cherries,
grapes,
grape
juice,
raisins
and
0.05
ppm
for
hops.
An
independent
laboratory
has
validated
the
method
using
hops,
which
is
typically
the
more
difficult
matrix
to
analyze.
3.
Magnitude
of
residues.
The
magnitude
of
residues
for
grape,
hops,
and
cherry
is
adequately
understood.

B.
Toxicological
Profile
1.
Acute
toxicity.
Quinoxyfen
technical
has
low
acute
toxicity.
The
acute
oral
lethal
dose
(
LD)
50
in
rats
was
>
5,000
milligrams/
kilogram
(
mg/
kg)
whereas,
the
dermal
(
LD)
50
in
rabbits
was
>
2,000
mg/
kg.
The
acute
inhalation
lethal
concentration
(
LC)
50
in
rats
was
greater
than
the
highest
attainable
aerosol
concentration
(
3.38
mg/
L).
Quinoxyfen
produced
no
dermal
irritation
and
only
mild
eye
irritation
in
rabbits.
A
guinea
pig
dermal
sensitization
study
conducted
by
the
modified
Buehler
method
found
no
sensitization,
whereas
a
study
conducted
by
the
Magnusson
and
Kligman
maximization
test
showed
a
positive
sensitization
reaction.
Formulations
of
quinoxyfen
are
water
based
suspension
concentrates
that
have
similar
low
acute
toxicity.
These
suspension
concentrates
are
classified
as
non­
sensitizer,
based
on
the
results
from
testing
in
guinea
pigs.
2.
Genotoxicity.
Quinoxyfen
was
negative
for
genotoxicity
when
tested
in
in
vitro
and
in
vivo
systems.
3.
Reproductive
and
developmental
toxicity.
Quinoxyfen
did
not
have
any
effect
on
reproductive
parameters
at
dose
levels
that
induced
treatmentrelated
effects
in
parental
rats.
Transient
decreases
in
pup
body
weights
were
seen
prior
to
weaning,
but
dietary
concentrations
were
targeted
for
adults
and
consumption
of
treated
diets
by
the
pups
resulted
in
dose
levels
to
the
pups
approximately
3­
fold
higher
than
in
adults.
Post­
weaning
weights
were
comparable
to
controls.
A
teratogenic
potential
for
quinoxyfen
was
not
demonstrated
in
either
rats
or
rabbits
at
dose
levels
that
induced
maternal
toxicity.
4.
Subchronic
and
chronic
toxicity.
Quinoxyfen
caused
increased
liver
weights
and
microscopic
hepatocellular
hypertrophy
when
given
at
sufficiently
high
dose
levels
in
rats
and
mice
for
13
weeks;
no
effects
were
observed
in
the
subchronic
dog
study
at
the
highest
dose
tested.
Very
high
dietary
levels
were
associated
with
slight
hepatocellular
necrosis.
Similar
increases
in
liver
weights
were
seen
in
chronic
studies.
In
addition,
increased
kidney
weights,
and
an
increase
in
the
incidence
of
chronic
progressive
glomerulonephropathy,
were
seen
after
24
months
in
female
rats
given
high
dose
levels
of
quinoxyfen.
Chronic
toxicity
seen
in
dogs
included
liver
effects
as
noted
above,
along
with
regenerative
anemia
at
high
dose
levels.
Using
the
Guidelines
for
Carcinogen
Risk
Assessment
published
September
24,
1986
(
51
FR
33992),
it
is
proposed
that
quinoxyfen
be
classified
as
Group
E
for
carcinogenicity
(
no
evidence
of
carcinogenicity)
based
on
the
results
of
studies
in
two
species.
Dow
AgroSciences
believes
there
was
no
evidence
of
carcinogenicity
in
an
18
 
month
mouse
feeding
study
and
a
24
 
month
rat
feeding
study
at
any
dosage
tested.
5.
Animal
metabolism.
Quinoxyfen
is
rapidly
absorbed,
extensively
metabolized
and
rapidly
eliminated
in
the
urine
and
feces.
Studies
conducted
with
14C­
quinoxyfen,
labeled
in
either
the
phenyl
ring
or
the
quinoline
ring,
indicated
extensive
cleavage
of
the
diaryl
ether
linkage.
There
were
no
substantive
differences
in
the
metabolism
and
disposition
of
quinoxyfen
between
males
and
females,
or
between
single
or
repeated
exposure.
Parent
quinoxyfen
was
not
found
in
the
urine;
although,
it
was
identified
in
the
feces.
The
major
metabolites
found
in
urine
and/
or
feces
included:
(
1)
Acidlabile
conjugates
of
the
phenyl
ring
moiety
(
4­
FP)
and
quinoline
ring
moiety
(
DCHQ);
(
2)
lesser
quantities
of
free
4­
FP
and
DCHQ;
and
(
3)
isomers
of
fluorophenyl­
ring
hydroxy­
quinoxyfen,
both
free
and
glucuronide
and/
or
sulfate
conjugates.
Trace
quantity
of
the
3­
OH
metabolite
was
also
identified
in
the
urine
and
feces
of
rats.
6.
Metabolite
toxicology.
The
nature
of
residue
studies
of
quinoxyfen
in
plants
indicated
that
the
majority
of
applied
radiolabeled
material
remained
as
the
parent
compound.
Analyses
from
nature
of
residues
studies
in
a
number
of
crops
revealed
low
residues
of
metabolites
(<
10%
TRR)
identified
as:
(
1)
A
quinoline­
ring
hydroxylated
metabolite,
most
likely
3­
OH;
(
2)
a
cyclized
deschloro
photoproduct
(
CFBPQ);
(
3)
4­
FP;
and
(
4)
a
metabolite
in
which
the
fluorine
was
replaced
by
a
hydroxyl
group.
Of
these
metabolites,
4­
FP
(
formed
by
ether
bridge
cleavage),
and
DCHQ
(
corresponding
to
the
other
half
of
the
molecule),
as
well
as
trace
quantities
of
3­
OH,
have
been
identified
in
rat
urine
and/
or
feces.
These
data
suggest
that
most
metabolites
formed
in
plants
are
similarly
formed
in
mammals
and
are
of
little
toxicologic
concern,
based
on
the
existing
data
for
quinoxyfen.
7.
Neurotoxicity.
Quinoxyfen
has
been
shown
to
have
no
neurotoxicologic
potential
based
on
acute
and
subchronic
studies.
8.
Endocrine
disruption.
There
is
no
evidence
from
any
studies
to
suggest
that
quinoxyfen
has
an
effect
on
any
endocrine
system.

C.
Aggregate
Exposure
1.
Dietary
exposure.
Potential
dietary
exposure
and
risk
assessment
was
estimated
using
DEEM
(
Dietary
Exposure
Evaluation
Model,
Version
7.76)
with
USDA
food
consumption
data
continuing
survey
of
food
intake
by
individuals
(
CSFII)
Survey
1994
 
1998.
i.
Food
 
a.
Acute
No
acute
dietary
risk
for
quinoxyfen
was
evaluated
since
no
appropriate
toxicity
endpoint
attributable
to
a
single
dose
could
be
identified.
Therefore,
an
acute
reference
dose
was
not
established.
b.
Chronic.
The
dietary
exposure
assessment
was
performed
using
a
conservative
approach
(
Tier
I)
and
the
estimated
theoretical
maximum
residue
contribution
(
TMRC)
was
based
on
the
proposed
tolerances
for
quinoxyfen
on
or
in
grapes,
hops,
and
cherries
with
the
assumption
that
100%
of
these
crops
were
treated
with
quinoxyfen.
ii.
Drinking
water.
Based
on
the
rapid
degradation
of
quinoxyfen
in
water
and
its
high
tendency
to
sorb
to
soils,
no
surface
water
or
ground
water
contamination
is
expected.
This
agrees
with
EPA
Tier
1
modeling
using
SciGrow
and
GENEEC
which
estimated
concentration
of
quinoxyfen
at
0.006
µ
g/
L
in
ground
water
and
241
µ
g/
L
in
surface
water,
respectively.
2.
Non­
dietary
exposure.
Quinoxyfen
is
not
currently
registered
for
non­
crop
uses.
Therefore,
aggregate
exposure
to
quinoxyfen
will
not
include
nondietary
non­
occupational
exposures.

D.
Cumulative
Effects
The
potential
for
cumulative
effects
of
quinoxyfen
and
other
substances
that
have
a
common
mechanism
of
toxicity
is
also
considered.
Quinoxyfen
is
a
member
of
the
quinoline
class
of
fungicides.
No
information
is
available
to
determine
whether
quinoxyfen
has
a
common
mechanism
of
toxicity
with
other
pesticides.
Therefore,
it
is
appropriate
to
consider
only
the
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potential
risks
of
quinoxyfen
in
an
aggregate
exposure
assessment.

E.
Safety
Determination
1.
U.
S.
population.
The
chronic
dietary
exposure
was
evaluated
using
a
chronic
reference
dose
(
RfD)
of
0.2
mg/
kg/
day
based
on
a
no
observed
adverse
effect
level
(
NOAEL)
of
20
mg/
kg/
day
from
chronic
rat,
chronic
dog,
and
rat
reproduction
studies
and
uncertainty
factor
of
100.
No
additional
Food
Quality
Protecction
Act
(
FQPA)
uncertainty
factor
is
needed.
For
the
U.
S.
general
population,
the
TMRC
was
estimated
to
be
0.000192
mg/
kg/
day.
Using
the
conservative
exposure
assumptions
described
in
Section
C.
and
based
on
the
completeness
and
reliability
of
the
toxicity
data,
the
aggregate
exposure
to
quinoxyfen
utilizes
0.1%
of
the
RfD
for
the
U.
S.
population.
EPA
generally
has
no
concern
for
exposures
below
100%
of
the
RfD
because
the
RfD
represents
the
level
at
or
below
which
daily
aggregate
dietary
exposure
over
a
lifetime
will
not
pose
appreciable
risks
to
human
health.
Thus,
there
is
a
reasonable
certainty
that
no
harm
will
result
from
aggregate
exposure
to
quinoxyfen
residues
from
the
proposed
uses.
2.
Infants
and
children.
FFDCA
section
408
provides
that
EPA
may
apply
an
additional
safety
factor
for
infants
and
children
in
the
case
of
threshold
effects
to
account
for
prenatal
and
postnatal
toxicity
and
the
completeness
of
the
data
base.
Based
on
the
current
toxicological
data
requirements,
the
data
base
for
quinoxyfen
relative
to
prenatal
and
postnatal
effects
for
children
is
complete.
In
assessing
the
potential
for
additional
sensitivity
of
infants
and
children
to
residues
of
quinoxyfen,
data
from
developmental
toxicity
studies
in
rats
and
rabbits
and
a
2­
generation
reproduction
study
in
the
rat
are
considered.
The
developmental
toxicity
studies
are
designed
to
evaluate
adverse
effects
on
the
developing
organism
resulting
from
pesticide
exposure
during
prenatal
development.
Reproduction
studies
provide
information
relating
to
effects
from
exposure
to
the
pesticide
on
the
reproductive
capability
and
potential
systemic
toxicity
of
mating
animals
and
on
various
parameters
associated
with
the
well­
being
of
offspring.
The
population
subgroup
with
the
highest
potential
exposure
are
children
(
1
 
6
yrs
old)
with
TMRC
of
0.00071
mg/
kg/
day.
Using
the
conservative
exposure
assumptions
previously
described
in
Section
C.
the
percent
RfD
utilized
by
the
potential
aggregate
exposure
to
quinoxyfen
residues
is
about
0.4%
for
children
(
1
 
6
yrs
old),
the
population
subgroup
with
highest
potential
exposure.
Quinoxyfen
had
no
effect
on
reproduction
or
embryo­
fetal
development
at
any
dosage
tested.
Therefore,
no
additional
FQPA
uncertainty
factor
is
needed.
Based
on
the
completeness
and
reliability
of
the
toxicity
data
and
the
conservative
exposure
assessment,
Dow
AgroSciences
concludes
that
there
is
a
reasonable
certainty
that
no
harm
will
result
to
infants
and
children
from
aggregate
exposure
to
quinoxyfen
residues
from
proposed
uses.
The
drinking
water
level
of
concern
(
DWLOC)
for
the
general
U.
S.
population
and
children
1
 
6
years
old
(
population
subgroup
with
the
highest
potential
exposure)
was
calculated
to
be
6,993
µ
g/
L
and
1,993
µ
g/
L,
respectively.
The
DWLOCs
are
substantially
greater
than
the
estimated
residue
concentration
in
ground
water
or
surface
water;
therefore,
exposure
to
quinoxyfen
would
not
result
in
unacceptable
levels
of
aggregate
human
health
risk.

F.
International
Tolerances
There
are
no
codex
maximum
residue
levels
established
for
residues
of
quinoxyfen
on
grapes,
hops,
and
cherries.
[
FR
Doc.
03
 
13562
Filed
5
 
29
 
03;
8:
45
am]

BILLING
CODE
6560
 
50
 
S
ENVIRONMENTAL
PROTECTION
AGENCY
[
OPP
 
2003
 
0170;
FRL
 
7309
 
2]

Diazinon;
Notice
of
Receipt
of
Requests
to
Voluntarily
Cancel
Certain
Pesticide
Registrations
AGENCY:
Environmental
Protection
Agency
(
EPA).
ACTION:
Notice.

SUMMARY:
In
accordance
with
section
6(
f)(
1)
of
the
Federal
Insecticide,
Fungicide,
and
Rodenticide
Act
(
FIFRA),
as
amended,
EPA
is
issuing
a
notice
of
receipt
of
requests
by
Syngenta
Crop
Protection,
Inc.
to
voluntarily
cancel
the
registrations
for
all
of
their
products
containing
diazinon,
O,
ODiethyl
O­(
2­
isopropyl­
6­
methyl­
4­
pyrimidinyl)
phosphorothioate.
EPA
intends
to
grant
these
requests
by
issuing
a
cancellation
order
at
the
close
of
the
comment
period
for
this
announcement,
unless
the
Agency
receives
substantive
comments
within
the
comment
period
that
would
merit
its
further
review
of
these
requests.
It
is
EPA's
intent
that
the
effective
date
of
the
cancellation
order,
as
requested
by
Syngenta,
will
be
June
30,
2003.
Syngenta's
April
8,
2003
cancellation
request
is
contingent
upon
EPA's
granting
of
certain
existing
stocks
provisions,
which
are
set
forth
in
this
Notice.

DATES:
Comments
on
the
requested
registration
cancellations
must
be
submitted
to
the
address
provided
below
and
identified
by
docket
ID
number
OPP
 
2003
 
0170.
Comments
must
be
received
on
or
before
June
30,
2003.

FOR
FURTHER
INFORMATION
CONTACT:
Stephanie
Plummer,
Special
Review
and
Reregistration
Division
(
7508C),
Office
of
Pesticide
Programs,
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460
 
0001;
telephone
number:
(
703)
305
 
0076;
e­
mail
address:
plummer.
stephanie@
epa.
gov.

SUPPLEMENTARY
INFORMATION:

I.
General
Information
A.
Does
this
Action
Apply
to
Me?

This
action
is
directed
to
the
public
in
general.
Although
this
action
may
be
of
particular
interest
to
persons
who
produce
or
use
pesticides,
the
Agency
has
not
attempted
to
describe
all
the
specific
entities
that
may
be
affected
by
this
action.
If
you
have
any
questions
regarding
the
information
in
this
notice,
consult
the
person
listed
under
FOR
FURTHER
INFORMATION
CONTACT.

B.
How
Can
I
Get
Copies
of
this
Document
and
Other
Related
Information?

1.
Docket.
EPA
has
established
an
official
public
docket
for
this
action
under
docket
identification
(
ID)
number
OPP
 
2003
 
0170.
The
official
public
docket
consists
of
the
documents
specifically
referenced
in
this
action,
any
public
comments
received,
and
other
information
related
to
this
action.
Although
a
part
of
the
official
docket,
the
public
docket
does
not
include
Confidential
Business
Information
(
CBI)
or
other
information
whose
disclosure
is
restricted
by
statute.
EPA
also
established
two
dockets
containing
documents
in
support
of
the
diazinon
IRED.
They
are
dockets
OPP
 
34225
and
OPP
 
2002
 
0251.
The
official
public
docket
is
the
collection
of
materials
that
is
available
for
public
viewing
at
the
Public
Information
and
Records
Integrity
Branch
(
PIRIB),
Rm.
119,
Crystal
Mall
#
2,
1921
Jefferson
Davis
Hwy.,
Arlington,
VA.
This
docket
facility
is
open
from
8:
30
a.
m.
to
4
p.
m.,
Monday
through
Friday,
excluding
legal
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2003
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