Document ID: EPA-HQ-OPP-2005-0176-0011
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2005-12-28T05:00Z

UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
OFFICE
OF
PREVENTION,
PESTICIDES,
AND
TOXIC
SUBSTANCES
WASHINGTON,
D.
C.
20460
MEMORANDUM
DATE:
September
20,
2005
SUBJECT:
MANCOZEB.
Short­
Term
Aggregate
Postapplication
Risk
in
Home
Gardens
to
Mancozeb­
Derived
ETU
DP
Barcode:
D321790
PC
Code:
014504
TO:
Christina
Scheltema,
Chemical
Review
Manager
Reregistration
Branch
3
Special
Review
and
Reregistration
Division,
7505W
FROM:
Kit
Farwell,
D.
V.
M.
Reregistration
Branch
1
Health
Effects
Division
(
7509C)

THRU:
Whang
Phang,
Ph.
D.,
Senior
Scientist
Reregistration
Branch
1
Health
Effects
Division
(
7509C)

This
memo
assesses
ETU
exposure
as
a
result
of
mancozeb
use
for
short­
term
aggregate
postapplication
risk
from
hand
harvesting
cucurbits
in
home
gardens.
This
memo
references
exposure
data
from
the
mancozeb
human
health
risk
assessment
(
June
3,
2005,
D317371).
Margins
of
exposure
are
significantly
higher
than
the
target
of
1000
and
are
therefore
not
of
concern.
2
Exposure
pathways
included
dietary
food
and
water
and
residential
dermal
from
postapplication
activities
in
the
home
garden.
Residential
postapplication
exposure
and
risk
were
calculated
for
both
youth
and
adults.
Postapplication
exposures
are
considered
short­
term
in
nature,
and
have
been
calculated
assuming
people
re­
enter
the
garden
on
the
day
of
application.
The
highest
postapplication
exposure
estimates
were
for
hand
harvesting
cucurbits
grown
in
the
West
on
the
day
of
application;
these
exposure
estimates
were
aggregated
with
ETU
exposure
from
food
and
water,
and
are
protective
for
all
other
lower
exposure
postapplication
activities.

Postapplication
exposures
for
adults
and
youth
(
Table
11)
were
added
to
chronic
food
and
ground
water
exposures
(
Table
15)
for
females
13­
49
(
adults),
and
to
the
chronic
food
and
ground
water
exposures
(
Table
15)
for
children
6­
12
(
youth),
respectively,
to
calculate
aggregate
exposure.
The
food
exposure
for
children
ages
6­
12
was
chosen
because
youth
gardeners
are
assumed
to
be
aged
10­
12.
Chronic
food
and
water
exposure
for
females
13­
49
were
used
for
adults
because
a
developmental
endpoint
was
selected
for
short­
term
risk
assessments
for
ETU.

Combined
food,
water
and
postapplication
exposures
to
ETU
were
compared
to
the
short­
term
NOAEL
of
5
mg/
kg/
day
for
females
13­
49,
and
to
the
short­
term
NOAEL
of
7
mg/
kg/
day
for
youth;
the
endpoint
selected
for
aggregate
risk
assessment
for
youth
and
toddlers
was
thyroid
effects.
ETU
short­
term
aggregate
postapplication
risks
for
home
gardeners
are
presented
in
Table
18.

Table
18.
ETU
Short­
Term
Aggregate
Postapplication
Risk,
Home
Garden.

Population
Residential
Postapplication
Absorbed
Dose
Dietary
Exposure
Aggregate
Exposure/
Risk
Food
Water
Exposure
MOE
Youth
0.00024
0.000025
0.000004
0.00027
26000
Adults
0.00031
0.000014
0.000004
0.00033
15000
Notes:
Absorbed
Dose
=
Dermal,
mg/
kg/
day.
(
Table
11)
Dietary
Exposure
=
Food
exposure
+
water
exposure
Food
Exposure
=
chronic
food
exposure
for
children
6­
12/
Females
13­
49,
mg/
kg/
day
(
Table
15)
Water
Exposure
=
chronic
water
exposure,
children
6­
12/
Females
13­
49,
mg/
kg/
day
(
Table
15)
Aggregate
Exposure
=
Absorbed
dose
+
food
exposure
+
water
exposure,
(
mg/
kg/
day)
Aggregate
MOE
(
Margin
of
Exposure)
=
NOAEL/
Aggregate
Exposure
[
Short­
term
NOAEL
for
youth
=
7
mg/
kg/
day;
short­
term
NOAEL
for
adults
=
5
mg/
kg/
day]