Document ID: EPA-HQ-OPPT-2005-0001-0002
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2005-10-06T04:00Z

Page
1
of
6
IUR
Petition
Review
Report
December
22,
2004
CASRNs
and
TSCA
Inventory
Chemical
Names:
56­
81­
5
1,2,3­
propanetriol
Alternate
Chemical
Names
Used
in
Petitions:
glycerol
glycerin
Petitioners
and
Docket
Numbers:
P&
G
Company
OPPT­
2003­
0059
Dow
Chemical
Company
OPPT­
2003­
0059
Keller
&
Heckman
OPPT­
2004­
0071
Note:
Other
chemicals
were
included
in
the
Keller
&
Heckman
petition,
and
these
other
chemicals
are
addressed
in
other
petition
review
reports.

Summary
of
Decision:
The
petition
review
group
determined
that,
at
this
time,
EPA
has
a
low
current
interest
in
the
processing
and
use
information
collected
under
the
Inventory
Update
Rule
(
IUR,
40
CFR
Part
710)
for
1,2,3­
propanetriol
(
CASRN
56­
81­
5)
and
therefore
is
recommending
a
grant
for
this
petition.
This
recommendation
is
based
primarily
on
Considerations
B
and
C.

EPA
will
initiate
rulemaking
to
add
1,2,3­
propanetriol
(
CASRN
56­
81­
5)
to
the
partial
exemption
list
at
40
CFR
710.46(
b)(
2)(
iv).
The
final
listing
decision
is
pending,
based
on
responses
to
the
FR
notice.
EPA
may
reevaluate
the
IUR
reporting
status
of
1,2,3­
propanetriol
(
CASRN
56­
81­
5)
if
the
Agency
obtains
new
information
indicating
a
need
for
processing
and
use
information.

Please
note
that
IUR
submitters
can
still
report
processing
and
use
information
even
if
a
chemical
is
partially
exempt,
so
that
their
chemicals
can
be
considered
for
safer
substitute
analyses.

Background:
EPA
received
a
petition
requesting
that
1,2,3­
propanetriol
(
CASRN
56­
81­
5)
be
exempted
from
reporting
processing
and
use
information
under
the
Inventory
Update
Reporting
rule
(
IUR)
(
See
40
CFR
710.46(
b)(
2)(
iv)).
The
chemical
substances
included
on
this
"
partial
exemption"
list
are
substances
for
which
EPA
has
previously
determined
that
there
is
a
low
current
interest
in
the
IUR
processing
and
use
information.
However,
as
stated
in
the
preamble
to
the
amendment
to
the
IUR
promulgated
on
January
7,
2003
(
68
FR
854),
"...
the
need
for
processing
and
use
information
...
changes
over
time.
The
inclusion
of
a
chemical
substance
under
this
partial
exemption
is
not
based
on
the
potential
risks
of
a
chemical.
This
partial
exemption
is
solely
intended
to
provide
a
tool
to
assist
the
Agency
in
better
managing
the
collection
of
processing
and
use
information..."
and
is
also
"
based
on
the
Agency's
current
need
for
collecting
IURA
processing
and
use
information."
(
68
FR
855)
Additionally,
the
preamble
states
"
In
determining
whether
there
is
low
current
interest
in
IURA
processing
and
use
information
related
to
a
specific
chemical
substance,
EPA
will
look
to
the
specific
circumstances
1See
the
attached
list
of
acronyms
at
the
end
of
this
report.

Page
2
of
6
surrounding
the
chemical
in
question,
and
may
use
one
or
more
of
the
considerations
identified
below,
and/
or
considerations
not
identified
below,
to
make
an
informed
decision."
The
considerations
used
by
EPA
in
reviewing
this
petition
and
an
analysis
of
how
those
considerations
relate
to
the
chemicals
identified
in
this
petition
are
set
forth
below.

Discussion:
The
petition
review
group
considered
information
submitted
with
the
petition,
as
well
as
other
information
including
(
but
not
limited
to):
whether
the
petition
substances
are
included
in
TRI,
IRIS,
or
IARC;
OECD
SIDS
program
status;
and
HPV
Challenge
Program
status
and
other
regulatory
programs
administered
by
EPA.
1
The
petition
from
Proctor
and
Gamble
(
docket
number
OPPT­
2003­
0059)
linked
information
provided
in
the
petition
to
specific
considerations
cited
in
40
CFR
710.46(
b)(
2)(
ii),
providing
a
citation
to
a
SIAR
and
other
information.
While
there
were
two
other
petitions
submitted,
EPA
relied
upon
the
information
submitted
by
Proctor
and
Gamble
for
this
review.

Consideration
A:
Production
volume.

The
petition
review
group
found
that
there
was
at
least
one
site
reporting
in
2002
with
a
production
volume
for
1,2,3­
propanetriol
(
CASRN
56­
81­
5)
of
300,000
pounds
or
greater.

Consideration
B:
The
substance's
chemical
and
physical
properties
or
potential
for
persistence,
bioaccumulation,
health
effects,
or
environmental
effects.

The
petition
included
the
SIAR
(
dated
01/
02/
2002)
for
1,2,3­
propanetriol
(
CASRN
56­
81­
5),
and
provided
a
summary
of
specific,
pertinent
details.
The
SIAR
concluded
that
there
is
a
low
hazard
potential
for
1,2,3­
propanetriol
(
CASRN
56­
81­
5)
(
Ref
1).
According
to
the
SIAP,
dated
March
2002,
the
"
weight
of
evidence
indicates
that
1,2,3­
propanetriol
(
CASRN
56­
81­
5)
is
of
low
toxicity
when
ingested,
inhaled,
or
in
contact
with
the
skin"
(
Ref
2).
The
petition
summary
of
the
SIAR
stated
that
1,2,3­
propanetriol
(
CASRN
56­
81­
5)
has
low
hazard
to
the
aquatic
environment.

Additionally,
the
petition
noted
that
"
the
SIAR
concluded
that
based
on
the
available
data,
glycerol:
1.
Is
considered
to
be
readily
biodegradable
in
the
aquatic
environment.
(
Section
2.1.5,
p.
5)
2.
Is
not
expected
to
bioaccumulate.
(
Section
2.1.6,
p.
5)
3.
Is
approved
for
use
as
a
direct
food
additive,
indirect
food
additive
and
is
recognized
as
generally
safe
for
use
in
food.
(
Section
2.2,
p.
6)
4.
Is
of
very
low
acute
toxicity
to
mammals.
(
Section
3.1.2.2,
p.
8)
5.
Has
no
in
vitro
or
in
vivo
data
indicating
a
genotoxic
potential.
(
Section
3.1.4,
p.
12)
6.
Does
not
raise
concern
for
carcinogenic
potential.
(
Section
3.1.5,
p.
12)
Page
3
of
6
7.
Does
not
have
any
adverse
effects
on
reproductive
parameters.
(
Section
3.1.6
p.
13)
8.
Is
not
irritating
when
in
contact
with
the
skin.
(
Section
3.1.7.1,
p.
13)
9.
Is
not
irritating
to
the
eyes.
(
section
3.1.7.2,
p.
14)
10.
Has
no
human
or
animal
data
indicating
it
is
a
skin
sensitizer.
(
Section
3.1.7.3,
p.
14)
11.
Is
of
low
acute
toxicity
to
fish
and
aquatic
invertebrates.
(
Section
4.1.
l,
p.
15)
12.
Is
of
low
acute
or
chronic
toxicity
to
algae.
(
Section
4.1.2,
p.
16)
13.
Is
of
low
toxicity
to
bacteria.
(
Section
4.1.3,
p.
17)
14.
Is
of
low
hazard
to
the
aquatic
environment.
(
Section
4.1.5,
p.
17)"

EPA
has
reviewed
this
information
and
concludes
at
this
time
that
there
is
no
evidence
of
concerns
about
persistence,
bioaccumulation,
human
health
effects
or
environmental
effects.

Consideration
C:
The
information
needs
of
EPA,
other
federal
agencies,
tribes,
states,
and
local
governments,
as
well
as
members
of
the
public.

1,2,3­
Propanetriol
(
CASRN
56­
81­
5)
was
originally
excluded
by
EPA
from
the
Agency's
HPV
Challenge
program
based
on
a
preliminary
EPA
review
indicating
that
testing
using
the
SIDS
base
set
would
not
further
our
understanding
of
the
chemical's
properties,
but
was
voluntarily
sponsored
by
the
ICCA
APAG
Glycerol
Group
and
therefore
is
part
of
the
HPV
Challenge
program.
Because
it
was
sponsored,
EPA
did
not
list
this
chemical
on
the
initial
list
of
partially
exempt
substances
at
40
CFR
710.46(
b)(
2)(
iv)
(
see
Methodology
Used
for
the
Initial
Selection
of
Chemicals
for
the
Inventory
Update
Rule
Amendments
(
IURA)
`
Low
Current
Interest'
Partial
Reporting
Exemption
for
additional
information).
However,
EPA
continues
to
believe
that
more
information
on
1,2,3­
propanetriol
(
CASRN
56­
81­
5)
would
not
further
our
understanding
of
this
chemical.
As
demonstrated
in
consideration
B,
there
is
no
evidence
of
concerns
about
persistence,
bioaccumulation,
human
health
effects,
or
environmental
effects,
and
therefore
the
IUR
processing
and
use
information
is
of
low
current
interest.

As
of
the
writing
of
this
report,
other
current
needs
for
IUR
processing
and
use
information
for
1,2,3­
propanetriol
(
CASRN
56­
81­
5)
were
not
identified.
This
petition
was
circulated
among
the
Interagency
Testing
Committee
members;
no
one
identified
a
current
interest
in
the
IUR
processing
and
use
information
for
this
chemical.
The
process
for
adding
this
chemical
to
the
partial
exemption
list
involves
publishing
a
Federal
Register
notice
asking
for
comment,
including
asking
if
there
is
interest
in
the
IUR
processing
and
use
information
for
this
chemical.

Consideration
D:
The
availability
of
other
complementary
risk
screening
information.

The
petition
noted
that
the
completed
SIAR
contains
risk
screening
information,
which
serves
as
a
source
of
complementary
risk
screening
information.
The
petition
also
listed
other
sources
of
additional
risk
screening
information,
and
that
the
conclusions
of
those
other
sources
agreed
with
the
conclusion
in
the
SIAR.
As
noted
in
consideration
B,
EPA
believes
that,
due
to
the
extremely
low
hazard
of
this
chemical,
additional
risk
screening
information
is
not
needed
at
this
time.
Page
4
of
6
Consideration
E:
The
availability
of
comparable
processing
and
use
information.

The
petition
noted
that
there
were
several
sources
of
processing
and
use
data
and
stated
that
data
from
those
sources
are
comparable
to
the
IUR
processing
and
use
data.
EPA
has
reviewed
those
sources
and
disagrees
that
the
data
are
comparable.
In
light
of
the
extremely
low
hazard
of
this
chemical,
however,
the
petition
review
group
believes
the
IUR
processing
and
use
information
for
1,2,3­
propanetriol
(
CASRN
56­
81­
5)
is
of
low
current
interest
at
this
time.
EPA
may
reevaluate
the
IUR
reporting
status
of
this
chemical
in
the
future
if
the
Agency
obtains
new
information
indicating
a
need
for
processing
and
use
information.

Consideration
F:
Whether
the
potential
risks
for
the
chemical
substance
are
adequately
managed
by
EPA
or
another
agency
or
authority.

The
petition
states
that
1,2,3­
propanetriol
(
CASRN
56­
81­
5)
use
and
manufacturing
would
primarily
fall
under
the
authority
of
EPA,
FDA,
OSHA,
and
CPSC.
The
petition
did
not
provide
specific
information
on
this
point,
and
therefore
EPA
could
not
evaluate
this
consideration.
However,
in
light
of
the
considerations
discussed
above,
the
workgroup
believes
the
IUR
processing
and
use
information
is
of
low
current
interest.

Other
Considerations:

Additionally,
the
petitioner
notes
that
1,2,3­
propanetriol
(
CASRN
56­
81­
5)
is
a
component
part
of
all
natural
triglycerides
and
related
mono/
diglycerides,
such
as
the
animal
fats
and
vegetable
oils
that
are
also
currently
listed
on
the
partial
exemption.
This
rationale
is
not
compelling
­
a
"
natural"
chemical
is
not
necessarily
a
safe
chemical
and
therefore
any
"
natural"
aspect
is
not
germane
to
the
determination
of
interest.

Cited
References:

1.
Screening
Information
Data
Set
(
SIDS)
Initial
Assessment
Report
(
SIAR)
for
SIAM
14,
January
2,
2002,
EPA
Docket
#
OPPT­
2003­
0059­
0003.

2.
Screening
Information
Data
Set
(
SIDS)
Initial
Assessment
Profile
(
SIAP),
March
2002,
available
at
http://
cs3­
hq.
oecd.
org/
scripts/
hpv/
Status/
DownloadFile.
ASP?
CASNUM=
56815&
StatusCode=
SIARC&
DataNo=
1
Sources
Searched:
(
Note:
These
sources
are
typically
searched
or
reviewed
to
gather
information
presented
in
the
petition
review
report).

American
Conference
of
Governmental
Industrial
Hygienists
(
ACGIH)
Threshold
Limit
Values
(
TLV­
TWA).
2003.
ACGIH,
Cincinnati
OH.
pp.
12­
61.

Agency
for
Toxic
Substances
and
Disease
Registry
(
ATSDR)
ToxFAQsTM
(
Frequently
asked
questions
about
contaminants
found
at
hazardous
waste
sites).
Available
at
http://
www.
atsdr.
cdc.
gov/
toxfaq.
html
California
Air
Resources
Board
List
of
Toxic
Air
Contaminant
Fact
Sheets,
available
at
http://
arbis.
arb.
ca.
gov/
toxics/
tac/
toctbl.
htm
Page
5
of
6
California
EPA,
Safe
Drinking
Water
and
Toxic
Enforcement
Act
of
1986:
List
of
chemicals
known
to
the
State
to
cause
cancer
or
reproductive
toxicity.
Listing
as
of
Nov.
14,
2003.
Available
at
http://
www.
oehha.
ca.
gov/
prop65/
CRNR_
notices/
list_
changes/
111403lsta.
html
International
Agency
of
Research
on
Cancer
(
IARC)
Overall
Evaluations
of
Carcinogenicity
to
Humans.
Available
at
http://
monographs.
iarc.
fr/
monoeval/
crthall.
html
Interagency
Testing
Committee
(
ITC)
Priority
Testing
List.
Available
at
http://
tsca­
itc.
syrres.
com/
Chemicals/

National
Advisory
Committee
Acute
Exposure
Guideline
Levels
(
AEGLs).
Available
at
http://
www.
epa.
gov/
oppt/
aegl/
index.
htm
Organisation
for
Economic
Cooperation
and
Development
(
OECD)
Integrated
HPV
Database,
http://
cs3­
hq.
oecd.
org/
scripts/
hpv/
index.
asp
United
Nations
Environment
Programme
(
UNEP)
persistent
organic
pollutants
(
POPs),
available
at
http://
www.
chem.
unep.
ch/
pops/
default.
html
United
Nations
Environment
Programme
(
UNEP)
Ozone
Secretariat,
Summary
Control
Measures,
available
at
http://
www.
unep.
org/
ozone/
Treaties_
and_
Ratification/
2B_
montreal_
protocol.
asp
U.
S.
EPA
Clean
Air
Act
(
CAA)
Hazardous
Air
Pollutants
(
HAPs).
Available
in
the
Clean
Air
Act,
section
112(
b),
available
at
http://
www.
epa.
gov/
air/
caa/
caa112.
txt
U.
S.
EPA.
Emergency
Planning
and
Community
Right­
to­
Know
Act
Section
313,
List
of
Toxic
Chemicals.
2001.
Office
of
Environmental
Information,
EPA
260­
B­
01­
001,
available
at
http://
www.
epa.
gov/
tri/
chemical/
chemlist2001.
pdf
U.
S.
EPA
HPV
(
High
Production
Volume)
Challenge
Program
and
Voluntary
Children's
Chemical
Evaluation
Program
(
VCCEP)
Web
sites
under
the
EPA
Chemical
Right­
to­
Know
Initiative,
http://
www.
epa.
gov/
chemrtk
U.
S.
EPA
Integrated
Risk
Information
System
(
IRIS)
Substance
List.
Available
at
http://
www.
epa.
gov/
iris/
subst/
index.
html
U.
S.
EPA.
National
Recommended
Water
Quality
Criteria:
2002.
Office
of
Water.
EPA­
822­
R­
02­
047.
Available
at
http://
www.
epa.
gov/
waterscience/
pc/
revcom.
pdf
U.
S.
EPA.
2004
Edition
of
the
Drinking
Water
Standards
and
Health
Advisories.
Office
of
Water.
EPA­
822­
R­
04­
005.
Available
at
http://
www.
epa.
gov/
waterscience/
drinking/
standards/
dwstandards.
pdf
U.
S.
EPA
Substance
Registry
System
(
SRS).
Available
at
http://
www.
epa.
gov/
srs/

U.
S.
Occupational
Safety
and
Health
Administration
(
OSHA)
Permissible
Exposure
Limits
(
PELs),
available
at
http://
www.
osha.
gov/
SLTC/
pel/
index.
html
List
of
Acronyms
Page
6
of
6
ACGIH
American
Conference
of
Governmental
Industrial
Hygienists
AEGL
Acute
Exposure
Guideline
Level
ARB
Air
Resources
Board
ATSDR
Agency
for
Toxic
Substances
and
Disease
Registry
CAA
Clean
Air
Act
CASRN
Chemical
Abstract
Service
Registry
Number
CICAD
Concise
International
Chemical
Assessment
Document
CPSC
Consumer
Product
Safety
Commission
EHC
Environmental
Health
Criteria
EPA
Environmental
Protection
Agency
EU
European
Union
FDA
Food
and
Drug
Administration
FFDCA
Federal
Food,
Drug,
and
Cosmetic
Act
FIFRA
Federal
Insecticide,
Fungicide,
and
Rodenticide
Act
GRAS
Generally
Recognized
as
Safe
HAP
Hazardous
Air
Pollutant
HPV
High
Production
Volume
HSDB
Hazardous
Substances
Databank
IARC
International
Agency
of
Research
on
Cancer
ICCA
International
Council
of
Chemical
Associations
IFCS
International
Forum
on
Chemical
Safety
IPCS
International
Programme
on
Chemical
Safety
IRIS
Integrated
Risk
Information
System
IRPTC
International
Register
of
Potentially
Toxic
Chemicals
ITC
Interagency
Testing
Committee
IUCLID
International
Uniform
Chemical
Information
Database
IUR
Inventory
Update
Reporting
Rule
IURA
Inventory
Update
Reporting
Rule
Amendment
NAICS
North
American
Industry
Classification
System
NIOSH
National
Institute
for
Occupational
Safety
and
Health
OECD
Organisation
for
Economic
Cooperation
and
Development
OECD
HPV
SIDS
or
OECD
HPV
SIDS
program
OECD/
SIDS
HPV
Chemicals
Programme
OPP
Office
of
Pesticide
Programs
OPPT
Office
of
Pollution
Prevention
and
Toxics
OSHA
Occupational
Safety
and
Health
Administration
PEL
Permissible
Exposure
Limit
POP
Persistent
Organic
Pollutant
SIAM
SIDS
Initial
Assessment
Meeting
SIAP
SIDS
Initial
Assessment
Profile
SIAR
SIDS
Initial
Assessment
Report
SIDS
Screening
Information
Data
Set
SRS
Substance
Registry
System
TLV­
TWA
Threshold
Limit
Value
Time­
Weighted
Average
TRI
Toxics
Release
Inventory
TSCA
Toxic
Substances
Control
Act
UNEP
United
Nations
Environment
Programme
VCCEP
Voluntary
Children's
Chemical
Evaluation
Program