Document ID: EPA-HQ-OPP-2009-0005-0005
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2009-12-18T05:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

								OFFICE OF

 PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM

Date:  		September 8, 2009

SUBJECT:	Tribenuron Methyl.  Chronic Dietary (Food and Drinking Water)
Exposure Assessment for the Petition Proposing Tolerances for Residues
in/on Corn and Soybean.

PC Code:  	128887	DP Number:	D365813

Decision No.:	400410	Registration No.:	352-632

Petition Nos.:	8F7432 and 8F7441	Regulatory Action:	Section 3 

Assessment Type:	Dietary	Registration Case No.:	None

TXR No.:	None	CAS No.:	101200-48-0

MRID No.:	None	40 CFR:	§180.451

FROM:	Breann Hanson, Biologist 

Alternative Risk Integration and Assessment (ARIA) Team

Risk Integration Minor Use and Emergency Response Branch 			
(RIMUERB)/Registration Division (RD; 7505P)

THROUGH:   William Cutchin, Acting Senior Branch Scientist

		ARIA Team

RIMERB/RD; 7505P

AND

Douglas Dotson, Ph.D., Chemist

Julie Van Alstine, MPH, Environmental Health Scientist

		Dietary Exposure Science Advisory Council (DESAC)

		Health Effects Division (HED; 7509P)

TO:		Breann Hanson, Biologist 

ARIA Team

RIMUERB/RD; 7505P

	Barbara Madden/Susan Stanton

	RIMUERB/RD; 7505P

Executive Summary

The purpose of this memorandum is to report the results of a chronic
dietary (food + drinking water) exposure analysis for the sulfonylurea
herbicide tribenuron methyl
(methyl-2-[[[[[4-methoxy-6-methyl-1,3,5-triazin-2-yl] methylamino]
carbonyl] amino] sulfonyl] benzoate).  In this analysis, the chronic
dietary exposure and risk estimates resulting from food and water intake
were determined for the general U.S. population and various population
subgroups. 

(DEEM-FCID™, Version 2.03) which uses food consumption data from the
U.S. Department of Agriculture’s (USDA’s) Continuing Surveys of Food
Intakes by Individuals (CSFII) from 1994-1996 and 1998.  This analysis
was performed to support two E.I. du Pont de Nemours and Company
(DuPont™) requests proposing Section 3 registrations for the use of
Express® Herbicide (EPA Reg. No. 352-632), a water-soluble granule (SG)
formulation containing 50% of the active ingredient (ai) tribenuron
methyl, for use in/on OPTIMUM®GAT® tolerant field corn (PP#8E7441) and
soybeans (PP#8E7432) for pre-plant, post-emergence, and post-harvest
control of certain annual grasses and broadleaf weeds at a maximum
single (and seasonal) use rate of 0.03125 pounds of ai per acre (lb
ai/A).  The label specifies pre-harvest intervals (PHIs) of 7 days for
field corn commodities, and 14 days for soybean forage and hay.  

In calculating dietary risk estimates, ARIA has compared the chronic
population-adjusted dose (cPAD) to the respective estimated dietary
exposures.  Typically, ARIA and HED have concerns regarding dietary risk
when the estimates exceed 100% of the cPAD.  With the conservative
assumptions noted below, risk estimates associated with dietary exposure
to tribenuron-methyl are significantly below ARIA’s and HED’s level
of concern.

 Acute Dietary (Food + Drinking Water) Exposure Results and
Characterization

There was no appropriate endpoint for assessing acute dietary exposure;
therefore, no acute dietary risk assessment was performed.

Chronic Dietary (Food + Drinking Water) Exposure Results and
Characterization

An unrefined chronic dietary analysis for tribenuron-methyl was
conducted using existing and ARIA-proposed tolerance levels, 100%
crop-treated (%CT), and DEEM (Version 7.81) default processing factors
(PFs).  An empirical PF of 0.07x was used for soybean, oil.  Drinking
water was incorporated directly into the dietary assessment using the
chronic concentration for groundwater generated by the Screening
Concentration in Ground Water (SCI-GROW;Version 2.3) Model at 6.8 ppb. 
The results of the analysis indicate that chronic risk from the dietary
(food + drinking water) exposure to tribenuron-methyl will not exceed
ARIA’s level of concern for the general U.S. population, and all
population subgroups.  The chronic dietary risk estimate for the highest
reported exposed population subgroup, all infants (<1 year old), is <8%
of the cPAD.  The general U.S. population utilizes <4% of the cPAD.

Cancer Exposure Results and Characterization

Tribenuron-methyl is classified as a possible human carcinogen.  A
separate assessment of cancer risk was not necessary, however, because
the chronic dietary risk assessment is protective of any potential risk
of carcinogenicity.

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which ARIA has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to point of departure (PoD, NOAEL, LOAEL,
e.g.) divided by the required uncertainty or safety factors.  

For acute and non-cancer chronic exposures, ARIA is concerned when
estimated dietary risk exceeds 100% of the PAD.  ARIA is generally
concerned when estimated cancer risk exceeds one in one million (i.e.,
the risk exceeds 1 x 10-6).  References which discuss the acute and
chronic risk assessments in more detail are available on the
EPA/pesticides web site:  “Available Information on Assessing Exposure
from Pesticides, A User’s Guide,” 6/21/2000, web link:     
HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see
SOP 99.6 (8/20/1999).

The most recent dietary risk assessment for tribenuron-methyl was
conducted by HED (DP#: 332685, D. Dotson, 12/6/2006).

II.	Residue Information

Tolerances:  Permanent tolerances are established for residues of
tribenuron methyl at levels ranging from 0.02 ppm in/on cotton and
canola commodities to 0.5 ppm in/on wheat hay (40CFR §180.451[a] and
[c]).  Tolerances have also been established at 0.05 ppm in/on field
corn forage, grain, and stover.  

Residue of Concern:  HED previously concluded that the residue of
concern in plants and drinking water is tribenuron methyl only.  

Recommended Tolerances:  As part of the current petitions (PP#8E7432 and
PP#8E7441), ARIA recommends (DP#: 360846, W. Drew, 9/2009) for the
permanent tolerances noted below for residues of tribenuron-methyl,
including its metabolites and degradates, under 40 CFR 180.451:

Soybean, hay	0.35 ppm

Soybean, forage	0.07 ppm

Soybean, seed	0.01 ppm

Soybean, hulls	0.04 ppm

Corn, field, grain	0.01 ppm

Corn, field, forage	0.15 ppm

Corn, field, stover	1.1 ppm

Grain, aspirated fractions	1.5 ppm

The above noted tolerances will amend any tolerances currently noted in
40 CFR 180.451 for the subject commodity.  

Residue Data Used for Chronic Assessment:  For this analysis existing
and ARIA-recommended tolerance levels, as well as 100% CT for all
commodities, were used.  The only 2 processed commodities in the
assessment are corn, syrup and soybean, oil.  The DEEM (Version 7.81)
default PF of 1.5x was used for corn syrup; an empirical PF of 0.07x was
used for soybean, oil (DP#: 360846, W. Drew, 9/2009).  Based on
recalculated maximum reasonably balanced diets (MRDBs) on livestock, and
available metabolism studies, finite residues of tribenuron methyl are
not expected to occur in cattle, goat, horse, sheep or hog commodities. 
Finite residues are also not expected to occur in eggs, poultry meat, or
poultry fat.   

III.	Drinking Water Data

™ into the food categories “water, direct, all sources” and
“water, indirect, all sources.” 

The Food Quality Protection Act (FQPA) Index Reservoir Screening Tool
(FIRST; Version 1.1.0) and SCI-GROW (Version 2.3) Models were used to
predict the estimated drinking water concentrations (EDWCs) in surface
and groundwater, respectively, for aerial applications on OPTIMUM® GAT
corn and soybean.  While the product label allows for up to three
applications per growing season with the total amount of active
ingredient applied not to exceed 0.063 lb. ai/A, for modeling purposes
the number of applications was limited to once per year.  EFED assumed
that the more conservative model EDWCs would be achieved by using a
single application at the maximum application rate.  The chronic EDWCs
as predicted by the FIRST Model ranged from 0.76 – 0.86 ppb.  The
groundwater EDWCs as predicted by the SCI-GROW Model was 4.95E-03 ppb. 
These EDWCs are lower than the EDWCs derived in an October 2006 drinking
water assessment completed by EFED for use on sunflower, cotton, field
corn, sorghum, soybean, canola, flax, and rice.  Modeling was based on a
use rate of three aerial applications of 0.015 lb ai/A, 14 days apart. 
In that assessment the acute and chronic surface water EDWCs predicted
by the FIRST Model were 4.1 ppb and 2.7 ppb, respectively; groundwater
acute and chronic EDWCs as predicted by the SCI-GROW Model was 6.8 ppb. 
Therefore, EFED recommends using the 2006 groundwater chronic EDWCs of
6.8 ppb to predict potential health risks associated with
tribenuron-methyl concentrations in surface and groundwater.

.	DEEM-FCID™ Program and Consumption Information

The tribenuron-methyl chronic dietary exposure assessment was conducted
using the DEEM-FCID™, which incorporates consumption data from
USDA’s CSFII, 1994-1996 and 1998.  The 1994-96, 1998 data are based on
the reported consumption of more than 20,000 individuals over two
non-consecutive survey days.  Foods “as consumed” (e.g., apple pie)
are linked to EPA-defined food commodities (e.g. apples, peeled fruit -
cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S,
baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA.  For chronic exposure assessment,
consumption data are averaged for the entire U.S. population and within
population subgroups, but for acute exposure assessment are retained as
individual consumption events.

Based on analysis of the 1994-96, 1998 CSFII consumption data, which
took into account dietary patterns and survey respondents, HED concluded
that it is most appropriate to report risk for the following population
subgroups: the general U.S. population, all infants (<1 year old),
children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49,
females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

V.	Toxicological Information

HED has previously agreed upon the doses and endpoints for use in human
health risk assessments for tribenuron-methyl; a discussion of the
toxicology and endpoint selection for tribenuron methyl can be found in
the TRED document (DP#: 301595, R. Griffin, 6/23/2004).  The chronic
dietary (food and water) risk assessment is based on the NOAEL of 0.8
mg/kg/day from a one-year dog study that demonstrated elevated bilirubin
blood levels, elevated AST blood levels, increased urinary volume, and a
reduction in body weight observed at the LOAEL of 8 mg/kg/day.  As no
acute toxicological effects have been associated with a single oral
exposure to tribenuron-methyl, an acute dietary endpoint and dose for
risk assessment were not identified.  Tribenuron methyl is classified as
a possible human carcinogen; however, a separate assessment of cancer
risk is not necessary because the chronic dietary risk assessment is
protective of any potential risk of carcinogenicity.

The doses relevant to dietary exposure are summarized in Table 1, below.

Table 1.  Summary of Toxicological Doses and Endpoints for
Tribenuron-methyl for Use in Dietary Risk Assessments

Exposure/

Scenario	POD	Uncertainty/

FQPA Safety Factors	RfD, PAD, Level of Concern for Risk Assessment	Study
and Toxicological Effects

Acute Dietary (All Populations)	N/A	N/A	N/A	No appropriate endpoint was
identified.  Therefore, this risk assessment is not required.    

Chronic Dietary (All Populations)	NOAEL = 0.8 mg/kg/day

	UFA=10X

UFH=10X

FQPA SF=1X

	Chronic RfD = 0.008 mg/kg/day

 

cPAD = cRfD ÷ FQPA SF = 0.008 mg/kg/day	

Chronic Dog

LOAEL = 8.2 mg/kg/day (in males) based on elevated bilirubin, AST,
increased urinary volume, and 20% reduction in body weight gain.

Cancer (oral, dermal, inhalation)	Tribenuron methyl is classified as a
possible human carcinogen.  A separate assessment of cancer risk is not
necessary, however, because the chronic dietary risk assessment is
protective of any potential risk of carcinogenicity.

Point of Departure (POD) = A data point or an estimated point that is
derived from observed dose-response data and  used to mark the beginning
of extrapolation to determine risk associated with lower environmentally
relevant human exposures.  NOAEL = no observed adverse effect level. 
LOAEL = lowest observed adverse effect level.  UF = uncertainty factor. 
UFA = extrapolation from animal to human (interspecies).  UFH =
potential variation in sensitivity among members of the human population
(intraspecies).  FQPA SF = FQPA Safety Factor.  PAD = population
adjusted dose (a = acute, c = chronic). RfD = reference dose.  N/A = not
applicable.  

VI.	Results/Discussion 

As stated above, for chronic dietary assessments, ARIA and HED are
concerned when dietary risk exceeds 100% of the cPAD.  The DEEM-FCID(
analyses estimate the dietary exposure of the U.S. population and
various population subgroups.  The results reported in Table 2 (below)
are for the general U.S. population (total), all infants <1, children
1-2, children 3-5, children 6-12, youths 13-19, females 13-49, adults
20-49, and adults 50+ years old for chronic exposure.  

using the DEEM-FCID™ software are below ARIA’s and HED’s level of
concern for the U.S. population and each of the population subgroups. 
Chronic dietary exposure utilized < 4% of the cPAD for the U.S.
population. Chronic dietary exposure for the highest reported exposed
population subgroup, all infants (<1 year old), utilized < 8% of the
cPAD.

The results of the chronic dietary exposure analysis are reported in the
Summary Table (Table 2, below).

Table 2.  Summary of Dietary (Food and Drinking Water) Exposure and Risk
for Tribenuron Methyl.  

Population Subgroup1	DEEM Acute Dietary Analysis,

95th Percentile	DEEM Chronic Dietary Analysis

	Exposure (mg/kg/day)	% aPAD	Exposure (mg/kg/day)	% cPAD

General U.S. Population	

NA 2

	0.000275	3.4

All Infants (< 1 year old)

0.000616	7.7

Children 1-2 years old

0.000516	6.5

Children 3-5 years old

0.000501	6.3

Children 6-12 years old

0.000348	4.3

Youth 13-19 years old

0.000237	3.0

Adults 20-49 years old

0.000244	3.1

Adults 50+ years old

0.000222	2.8

Females 13-49 years old

0.000233	2.9

1 Values for the population with the highest risk for each type of risk
assessment are bolded.  

2 NA = Not Applicable; no acute dietary endpoint was identified for
these population subgroups.

VII.	Characterization of Inputs/Outputs

Very conservative assumptions were made in this chronic dietary exposure
analysis.  Residues in foods were assumed to be equivalent to the
tolerance levels.  Tolerance level residues should always exceed the
residue levels found on food commodities at the time of consumption. 
When field trials are performed, the maximum allowable application rate
is used and crops are harvested at the minimum PHI.  Samples are stored
frozen until analysis to ensure minimal degradation of residues.  In
actual practice, however, growers will not usually use the maximum
application rates for economic reasons.  In addition, most crops are not
harvested and immediately stored frozen.  A conservative residue value
was used for drinking water as well.  The groundwater value used was a
conservative, unrefined value and was higher than the estimated surface
water concentrations that were generated.  For these reasons, ARIA and
HED are confident that this analysis does not underestimate dietary risk
to the general U.S. population or any population subgroup.

VII.	Conclusions

Based on the conservative assumptions noted above, dietary risk
estimates for tribenuron-methyl do not exceed ARIA’s or HED’s level
of concern for the general U.S. population, or any of the population
subgroups, including those comprised of infants and children.  

VIII.	List of Attachments

Attachment 1:  Chronic Food plus Water Residue Input File

Attachment 2:  Chronic Results File

Attachment 1:  Chronic Food plus Water Residue Input File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for TRIBENURON                        
1994-98 data

Residue file: C:\Documents and Settings\bhanson\My Documents\Breann's
Work\Aria\Tribenuron\8F7432\FINALS\128887.R98

                                                           Adjust. #2
NOT used

Analysis Date 08-25-2009             Residue file dated:
08-25-2009/12:37:48/8

Reference dose (RfD) = 0.008 mg/kg bw/day

Comment:PP#: 8F7432 and 8F7441 (8/2009)

------------------------------------------------------------------------
-------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   

15000250 15   Barley, pearled barley             0.050000   1.000     
1.000   

15000251 15   Barley, pearled barley-babyfood    0.050000   1.000     
1.000   

15000260 15   Barley, flour                      0.050000   1.000     
1.000   

15000261 15   Barley, flour-babyfood             0.050000   1.000     
1.000   

15000270 15   Barley, bran                       0.050000   1.000     
1.000   

15001200 15   Corn, field, flour                 0.010000   1.000     
1.000   PP# 8E

  Full comment: PP# 8E7441

15001201 15   Corn, field, flour-babyfood        0.010000   1.000     
1.000   PP# 8E

  Full comment: PP# 8E7441

15001210 15   Corn, field, meal                  0.010000   1.000     
1.000   PP# 8E

  Full comment: PP# 8E7441

15001211 15   Corn, field, meal-babyfood         0.010000   1.000     
1.000   PP# 8E

  Full comment: PP# 8E7441

15001220 15   Corn, field, bran                  0.010000   1.000     
1.000   PP# 8E

  Full comment: PP# 8E7441

15001230 15   Corn, field, starch                0.010000   1.000     
1.000   PP# 8E

  Full comment: PP# 8E7441

15001231 15   Corn, field, starch-babyfood       0.010000   1.000     
1.000   PP# 8E

  Full comment: PP# 8E7441

15001240 15   Corn, field, syrup                 0.010000   1.500     
1.000   PP# 8E

  Full comment: PP# 8E7441

15001241 15   Corn, field, syrup-babyfood        0.010000   1.500     
1.000   PP# 8E

  Full comment: PP# 8E7441

15001250 15   Corn, field, oil                   0.010000   1.000     
1.000   PP# 8E

  Full comment: PP# 8E7441

15001251 15   Corn, field, oil-babyfood          0.010000   1.000     
1.000   PP# 8E

  Full comment: PP# 8E7441

95001280 O    Cottonseed, oil                    0.020000   1.000     
1.000   

95001281 O    Cottonseed, oil-babyfood           0.020000   1.000     
1.000   

20001630 20   Flaxseed, oil                      0.020000   1.000     
1.000   

15002310 15   Oat, bran                          0.050000   1.000     
1.000   

15002320 15   Oat, flour                         0.050000   1.000     
1.000   

15002321 15   Oat, flour-babyfood                0.050000   1.000     
1.000   

15002330 15   Oat, groats/rolled oats            0.050000   1.000     
1.000   

15002331 15   Oat, groats/rolled oats-babyfood   0.050000   1.000     
1.000   

20003190 20   Rapeseed, oil                      0.020000   1.000     
1.000   

20003191 20   Rapeseed, oil-babyfood             0.020000   1.000     
1.000   

15003230 15   Rice, white                        0.050000   1.000     
1.000   

15003231 15   Rice, white-babyfood               0.050000   1.000     
1.000   

15003240 15   Rice, brown                        0.050000   1.000     
1.000   

15003241 15   Rice, brown-babyfood               0.050000   1.000     
1.000   

15003250 15   Rice, flour                        0.050000   1.000     
1.000   

15003251 15   Rice, flour-babyfood               0.050000   1.000     
1.000   

15003260 15   Rice, bran                         0.050000   1.000     
1.000   

15003261 15   Rice, bran-babyfood                0.050000   1.000     
1.000   

15003440 15   Sorghum, grain                     0.050000   1.000     
1.000   

15003450 15   Sorghum, syrup                     0.050000   1.000     
1.000   

06003470 6    Soybean, seed                      0.010000   1.000     
1.000   PP# 8E

  Full comment: PP# 8E7432

06003480 6    Soybean, flour                     0.010000   1.000     
1.000   PP# 8E

  Full comment: PP# 8E7432

06003481 6    Soybean, flour-babyfood            0.010000   1.000     
1.000   PP# 8E

  Full comment: PP# 8E7432

06003490 6    Soybean, soy milk                  0.010000   1.000     
1.000   PP# 8E

  Full comment: PP# 8E7432

06003491 6    Soybean, soy milk-babyfood or in   0.010000   1.000     
1.000   PP# 8E

  Full comment: PP# 8E7432

06003500 6    Soybean, oil                       0.010000   0.070     
1.000   PP# 8E

  Full comment: PP# 8E7432

06003501 6    Soybean, oil-babyfood              0.010000   0.070     
1.000   PP# 8E

  Full comment: PP# 8E7432

20003640 20   Sunflower, seed                    0.050000   1.000     
1.000   

20003650 20   Sunflower, oil                     0.050000   1.000     
1.000   

20003651 20   Sunflower, oil-babyfood            0.050000   1.000     
1.000   

86010000 O    Water, direct, all sources         0.006800   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.006800   1.000     
1.000   

15004010 15   Wheat, grain                       0.050000   1.000     
1.000   

15004011 15   Wheat, grain-babyfood              0.050000   1.000     
1.000   

15004020 15   Wheat, flour                       0.050000   1.000     
1.000   

15004021 15   Wheat, flour-babyfood              0.050000   1.000     
1.000   

15004030 15   Wheat, germ                        0.050000   1.000     
1.000   

15004040 15   Wheat, bran                        0.050000   1.000     
1.000   

15004050 15   Wild rice                          0.050000   1.000     
1.000  

Attachment 2:  Chronic Results File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for TRIBENURON                       (1994-98
data)

Residue file name: C:\Documents and Settings\bhanson\My
Documents\Breann's Work\Aria\Tribenuron\8F7432\FINALS\128887.R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 08-25-2009/12:38:29     Residue file dated:
08-25-2009/12:37:48/8

Reference dose (RfD, Chronic) = .008 mg/kg bw/day

COMMENT 1: PP#: 8F7432 and 8F7441 (8/2009)

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.000275                
3.4%

U.S. Population (spring season)             0.000276                
3.4%

U.S. Population (summer season)             0.000284                
3.5%

U.S. Population (autumn season)             0.000269                
3.4%

U.S. Population (winter season)             0.000270                
3.4%

Northeast region                            0.000268                
3.3%

Midwest region                              0.000279                
3.5%

Southern region                             0.000258                
3.2%

Western region                              0.000302                
3.8%

Hispanics                                   0.000300                
3.7%

Non-hispanic whites                         0.000268                
3.4%

Non-hispanic blacks                         0.000264                
3.3%

Non-hisp/non-white/non-black                0.000350                
4.4%

All infants (< 1 year)                      0.000616                
7.7%

Nursing infants                             0.000248                
3.1%

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Non-nursing infants                         0.000755                
9.4%

Children 1-6  yrs                           0.000497                
6.2%

Children 7-12 yrs                           0.000331                
4.1%

Females 13-19 (not preg or nursing)         0.000217                
2.7%

Females 20+ (not preg or nursing)           0.000231                
2.9%

Females 13-50 yrs                           0.000244                
3.1%

Females 13+ (preg/not nursing)              0.000250                
3.1%

Females 13+ (nursing)                       0.000320                
4.0%

Males 13-19 yrs                             0.000256                
3.2%

Males 20+ yrs                               0.000241                
3.0%

Seniors 55+                                 0.000220                
2.8%

Children 1-2 yrs                            0.000516                
6.5%

Children 3-5 yrs                            0.000501                
6.3%

Children 6-12 yrs                           0.000348                
4.3%

Youth 13-19 yrs                             0.000237                
3.0%

Adults 20-49 yrs                            0.000244                
3.1%

Adults 50+ yrs                              0.000222                
2.8%

Females 13-49 yrs                           0.000233                
2.9%

Tribenuron methyl	                                               
Dietary Assessment                                  DP#:  365813

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