Document ID: EPA-HQ-OPP-2007-1202-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2009-03-25T04:00Z

SEQ CHAPTER \h \r 1 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460      

	OFFICE OF PREVENTION, PESTICIDESs

                                                                        
                   AND TOXIC SUBSTANCES

	

MEMORANDUM

Date:  		September 30, 2008  

SUBJECT:	Propiconazole  Acute and Chronic Aggregate Dietary (Food and
Drinking Water) Exposure and Risk Assessments for the Section 3
Registrations on Garden Beets, Turnips, Parsley, Cilantro and Pineapple.
 Petition No.:  7E7300.

PC Code:  122101	DP Barcode:   D355821

Decision No.: 386896	Registration No.: 100-617, 100-780

Petition No.: 7E7300	Regulatory Action: Section 3

Risk Assessment Type: Dietary assessment	Case No.: 3125.

TXR No.: N/A	CAS No.: 60207-90-1

MRID No.: N/A	40 CFR: § 180.434

FROM:	Yan Donovan, Chemist

Reregistration Branch 4/Health Effects Division (7509P)

THROUGH:	Anant Parmar, Biologist

Thurston Morton, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P)

and

Susan Hummel, Branch Senior Scientist

Branch/Health Effects Division (7509P)

TO:		Yan Donovan, Chemist/Risk Assessor

		Reregistration Branch 4/Health Effects Division (7509P)

and

Dan Rosenblatt/Shaja Joyner, PM#5

RIMUERB

Registration Division 

DEEM-FCID™, Version 2.03 which use food consumption data from the U.S.
Department of Agriculture’s Continuing Surveys of Food Intakes by
Individuals (CSFII) from 1994-1996 and 1998.  The analyses were
performed to support section 3 registrations on garden beets, turnips,
parsley, cilantro (coriander), the leaves of the root and tuber
vegetable group (crop group 2),  and as seed piece and postharvest dip
treatments for pineapple.  This petition was submitted by the
Interregional Research Project No. 4 (IR-4), on behalf of the
Agricultural Experiment Stations of CA, GA, HI, MS, NJ, OH, OK, OR, SC,
TN, and TX, to amend the use pattern for the 3.6 lb/gal emulsifiable
concentrate (EC) formulation of propiconazole (Tilt® Fungicide, EPA
Reg. No. 100-617) to add the above new uses.  IR-4 also requested the
use of the 45% WP formulation (EPA Reg. No. 100-780) of propiconazole on
pineapple as a postharvest dip treatment.

Attached are acute and chronic dietary risk assessments for these new
uses.   This dietary assessment is for the parent propiconazole only. 
The common metabolites- triazole, triazolylalanine (TA), and
triazolylacetic acid (TAA) are also residues of concern.  Since these
are common metabolites from several triazole pesticides, the risk
assessment for triazoles will be assessed separately.

   

Acute Dietary (Food and Drinking Water) Exposure Results and
Characterization

An acute dietary analysis for propiconazole was conducted using
tolerance levels and 100 %CT for all existing and proposed uses.  The
acute PAD is 0.3 mg/kg/day for all population subgroups (includes
females 13-49 years).  The results of the analysis indicate that acute
risk from the dietary exposure (food and water) to propiconazole from
the requested uses did not exceed HED’s level of concern for the U.S.
population or any population subgroup.  At the 95th percentile, the
exposure to the U.S. population is at 7 % aPAD; the highest exposed
subgroup (all infants <1 yrs old) is at 16% aPAD.

Chronic Dietary (Food and Drinking Water) Exposure Results and
Characterization

A chronic dietary analysis for propiconazole was conducted using
tolerance levels and 100 %CT for all existing and proposed uses.  The
cPAD is 0.1 mg/kg/day.  Results of the analysis indicate that chronic
risk from the dietary exposure (food and water) to propiconazole from
the requested use did not exceed HED’s level of concern for the U.S.
population or any population subgroup.  The exposure to the U.S.
population is at 7 % cPAD, and the most highly exposed subgroup,
Children 1-2 years old, is at 17 % cPAD.

Cancer Dietary (Food and Drinking Water) Exposure Results and
Characterization

The HED Carcinogenicity Peer Review Committee (CPRC) classified
propiconazole as Group C - possible human carcinogen and recommended
that for the purpose of risk characterization the reference Dose (RfD)
approach should be used and would be protective.



I.	Introduction

Propiconazole is a triazole-type fungicide that provides broad spectrum
disease control through inhibition of sterol biosynthesis in fungi.  It
is registered to Syngenta Crop Protection for the control of fungal
diseases on a variety of crops.   IR-4 has proposed use of the 3.6
lb/gal EC formulation of propiconazole on garden beet, turnip, parsley,
cilantro, and pineapple, and use of the 45% WP formulation of
propiconazole on pineapple.  

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL,
e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  HED is generally
concerned when estimated cancer risk exceeds one in one million.
References which discuss the acute and chronic risk assessments in more
detail are available on the EPA/pesticides web site:  “Available
Information on Assessing Exposure from Pesticides, A User’s Guide,”
21-JUN-2000, web link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see
SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for propiconazole was conducted
by Yan Donovan supporting the human health risk assessment for
propiconazole new uses on tree nuts, corn, cereal grains, legume
vegetables, soybeans, berries, strawberry, sugar beet, carrots and
onions (HED memo of Y. Donovan, DP 312278, 08/15/06).

II.	Residue Information

Residue Data used for Acute and Chronic Assessments:

These acute and chronic assessments were based on the assumption of
tolerance-level residues for all commodities with existing and proposed
tolerances and 100% crop treated (%CT) for all commodities.  The
existing tolerances are listed in 40 CFR §180.434.  The proposed new
tolerance levels used in the DEEM are presented in Table 1 (3rd column
in Table 1 below).  Table 1 is from the residue chemistry summary
chapter for propiconazole by Y. Donovan, 07/28/08, D348248.  DEEM
default processing factors from DEEM (Version 7.81) were used for all
processed commodities that do not have individual tolerances, except for
pineapple juice where available processing study indicated that there is
no concentration of residues in pineapple juice.

Propiconazole existing tolerances:



Sec. 180.434  Propiconazole; tolerances for residues.

    (a) General. 

-----------------------------------------------------------------------

                                                              Parts per

                          Commodity                             million

-----------------------------------------------------------------------

Almond, hulls..............................................        7.0

Banana......................................................        0.2

Barley, bran................................................        0.6

Barley, grain...............................................        0.3

Barley, hay.................................................        1.4

Barley, straw...............................................       10

Beet, sugar, dried pulp.....................................        1.0

Beet, sugar, molasses.......................................        1.5

Beet, sugar, roots..........................................        0.3

Beet, sugar, tops...........................................       10

Berry, group 13.............................................        1.0

Carrot, roots...............................................       0.25

Cattle, fat.................................................       0.05

Cattle, kidney..............................................        2.0

Cattle, liver...............................................        2.0

Cattle, meat................................................       0.05

Cattle, meat byproducts, except liver and kidney............       0.05

Corn, field, forage.........................................       12

Corn, field, grain..........................................        0.2

Corn, field, stover.........................................       30

Corn, pop, grain............................................        0.2

Corn, pop, stover...........................................       30

Corn, sweet, forage.........................................        6.0

Corn, sweet, kernel plus cob with husks removed.............        0.1

Corn, sweet, stover.........................................       30

Fruit, stone, group 12......................................        1.0

Goat, fat...................................................       0.05

Goat, kidney................................................        2.0

Goat, liver.................................................        2.0

Goat, meat..................................................       0.05

Goat, meat byproducts, except liver and kidney..............       0.05

Grain, aspirated fractions..................................       30

Grass, forage...............................................        0.5

Grass, hay..................................................        0.5

Grass, straw................................................       40

Hog, kidney.................................................        0.2

Hog, liver..................................................        0.2

Horse, fat..................................................       0.05

Horse, kidney...............................................        2.0

Horse, liver................................................        2.0

Horse, meat.................................................       0.05

Horse, meat byproducts, except liver and kidney.............       0.05

Leaf petioles, subgroup 4B..................................        5.0

Milk........................................................       0.05

Mushroom....................................................        0.1

Nut, tree, group 14.........................................        0.1

Oat, forage.................................................        1.7

Oat, grain..................................................        0.3

Oat, hay....................................................        1.4

Oat, straw..................................................       10

Onion, bulb.................................................        0.2

Onion, green................................................        9.0

Peanut......................................................        0.2

Peanut, hay.................................................       20

Peppermint, tops............................................        3.5

Pineapple...................................................        0.1

Pistachio...................................................        0.1

Rice, bran..................................................       15

Rice, grain.................................................        7.0

Rice, hulls.................................................       20

Rice, straw.................................................       18

Rye, bran...................................................        0.6

Rye, forage.................................................        1.7

Rye, grain..................................................        0.3

Rye, straw..................................................       10

Sheep, fat..................................................       0.05

Sheep, kidney...............................................        2.0

Sheep, liver................................................        2.0

Sheep, meat.................................................       0.05

Sheep, meat byproducts, except liver and kidney.............       0.05

Sorghum, grain, forage......................................       12

Sorghum, grain, grain.......................................        3.5

Sorghum, grain, stover......................................       15

Soybean, forage.............................................       11

Soybean, hay................................................       30

Soybean, seed...............................................        2.0

Spearmint, tops.............................................        3.5

Strawberry..................................................        1.3

Wheat, bran.................................................        0.6

Wheat, forage...............................................        1.7

Wheat, grain................................................        0.3

Wheat, hay..................................................        1.4

Wheat, straw................................................       10

-----------------------------------------------------------------------

    (b) Section 18 emergency exemptions. 

-----------------------------------------------------------------------

                                                            Expiration/

                    Commodity                     Parts per  revocation

                                                   million       date

-----------------------------------------------------------------------

Nectarine.......................................       2.0   12/31/2010

Peach...........................................       2.0   12/31/2010

-----------------------------------------------------------------------

    (c) Tolerances with regional registrations

-----------------------------------------------------------------------

                                                            

								Parts per

                          Commodity                             million

-----------------------------------------------------------------------

 Cranberry..................................................        1.0

Rice, wild, grain...........................................        0.5

-----------------------------------------------------------------------

    (d) Indirect or inadvertent residues.

-----------------------------------------------------------------------

                                                              Parts per

                          Commodity                             million

-----------------------------------------------------------------------

 Alfalfa, forage............................................        0.1

Alfalfa, hay................................................        0.1

-----------------------------------------------------------------------

[71 FR 55306, Sept. 22, 2006, as amended at 72 FR 20439, Apr. 25, 2007]



Propiconazole new recommended tolerances associated with petition
7E7300:

Table 1. 	Tolerance Summary for Propiconazole

Commodity	Proposed Tolerance (ppm)	Recommended Tolerance (ppm)	Comments;
Correct Commodity Definition

Vegetables, leaves of root and tuber, group 2	8.0	Remove	Insufficient
data have been submitted to support a crop group tolerance

Beet, garden, roots	0.6	0.30	Adjusted for 1x application rate

Beet, garden, tops	None	5.5

	Turnip, roots	0.2	Remove	A new set of crop field trial data are needed
if tolerances are to be established.

Turnip, tops	None	Remove

	Parsley, fresh	13	13	Parsley, leaves

Parsley, dried 	60	35	Parsley, dried leaves

Cilantro, leaves	13	13	Coriander, leaves

Pineapple	0.91	4.5	The recommend tolerance will cover the existing
tolerance

Pineapple, process residue	None	7.0

	1  A tolerance for propiconazole residues in/on pineapple is currently
established at 0.1 ppm [40 CFR 180.434(a)].

 Drinking Water Data

The drinking water residues used in the dietary risk assessment were
provided by the Environmental Fate and Effects Division (EFED) in the
following memorandum: “Drinking Water Assessment for Propiconazole
Uses on Garden Beet, Turnip, Leaves of Root and Tuber Vegetables, Herbs,
and Pineapple – An IR-4 Action” (Jim Lin, 07/02/08, D347906) and
incorporated directly into this dietary assessment.  Water residues were
incorporated in the DEEM-FCID into the food categories “water, direct,
all sources” and “water, indirect, all sources.”   

The proposed new use rates are much less than the existing turf use of 8
applications at a rate of 0.786 lb ai/ac with a 14-day interval. 
Therefore, the drinking water assessment was based on  turf use rate.  

The estimated surface water drinking water concentrations for
propiconazole are:  

55.78 ug /L for the 1 in 10 year annual peak concentration (acute)  

21.61 ug /L for the 1 in 10 year annual mean concentration (non-cancer
chronic) and  

13.24 ug /L for the 30 year annual mean concentration (cancer chronic). 
 

0.64 μg/L

The highest estimates from surface water (acute, 55.8 ppb and chronic,
21.6 ppb) are directly entered into the exposure model to assess the
contributions from drinking water.  

The model and its description are available at the EPA internet site:  
HYPERLINK "http://www.epa.gov/oppefed1/models/water/" 
http://www.epa.gov/oppefed1/models/water/ .  

IV.	DEEM-FCID™ Program and Consumption Information

Propiconazole acute and chronic dietary exposure assessments were
conducted using the Dietary Exposure Evaluation Model software with the
Food Commodity Intake Database DEEM-FCID™, Version 2.03 which
incorporates consumption data from USDA’s Continuing Surveys of Food
Intakes by Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98
data are based on the reported consumption of more than 20,000
individuals over two non-consecutive survey days.  Foods “as
consumed” (e.g., apple pie) are linked to EPA-defined food commodities
(e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicly available recipe
translation files developed jointly by USDA/ARS and EPA.  For chronic
exposure assessment, consumption data are averaged for the entire U.S.
population and within population subgroups, but for acute exposure
assessment are retained as individual consumption events.  Based on
analysis of the 1994-96, 98 CSFII consumption data, which took into
account dietary patterns and survey respondents, HED concluded that it
is most appropriate to report risk for the following population
subgroups: the general U.S. population, all infants (<1 year old),
children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49,
females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., only those who reported
eating relevant commodities/food forms) and a per-capita (i.e., those
who reported eating the relevant commodities as well as those who did
not) basis.  In accordance with HED policy, per capita exposure and risk
are reported for all tiers of analysis.  However, for tiers 1 and 2, any
significant differences in user vs. per capita exposure and risk are
specifically identified and noted in the risk assessment.

V.	Toxicological Information

HED’s Hazard Identification Assessment Review Committee (HIARC)
concluded that the toxicology database for propiconazole is complete for
FQPA assessment.  Endpoints and dose response have been selected for
acute and chronic dietary exposures.

The HIARC also concluded that the database was adequate to characterize
any potential for prenatal or postnatal risk for infants and children. 
There is low concern for pre- and/or postnatal toxicity resulting from
exposure to propiconazole, and no residual uncertainties were
identified.  The Special FQPA factor is thus 1X.  The HIARC had
previously determined that an acute neurotoxicity (ACN) study was
required based on neurotoxic signs in pregnant rats administered high
propiconazole doses (360 mg/kg/day) during gestation.  HIARC had
determined that for acute (single dose) and short-term exposure
scenarios a 3X database uncertainty factor (UFDB) was adequate to
account for the lack of the ACN.  In September 2005 the ACN was
submitted to the Agency and reviewed.  The study confirms that
neurotoxic signs are observed at high doses, but there was no
neuropathology and there were no effects on neurobehavioral parameters. 
Accordingly, the propiconazole risk assessment team determined that a
developmental neurotoxicity study was not necessary and the database
uncertainty factor for acute and short-term scenarios was removed.

The HED Carcinogenicity Peer Review Committee (CPRC) classified
propiconazole as Group C - possible human carcinogen and recommended
that for the purpose of risk characterization the reference Dose (RfD)
approach should be used and would be protective.



Table 2  Summary of Toxicological Doses and Endpoints for Propiconazole
for Use in Dietary Exposure Risk Assessments

Exposure/

Scenario	Point of Departure	Uncertainty/FQPA Safety Factors	RfD, PAD,
Level of Concern 	Study and Toxicological Effects

Acute Dietary (General Population, including Infants and Children)
NOAEL= 30 mg/kg/day	UFA= 10x

UFH= 10x

FQPA SF= 1x

	Acute RfD = 0.3 mg/kg/day

aPAD =0.3 mg/kg/day	Acute neurotoxicity study LOAEL = 100 mg/kg/day
based on clinical signs of toxicity (piloerection in one male, diarrhea
in one female, tip toe gait in 3 females).

Acute Dietary

(Females 13-49 years of age)	NOAEL = 30 mg/kg/day	UFA= 10x

UFH= 10x

FQPA SF= 1x

	Acute RfD = 0.3 mg/kg/day	Developmental Toxicity Study - Rats.

LOAEL = 90 mg/kg/day based on  increased incidence of rudimentary ribs, 
un-ossified sternebrae, as well as increased incidence of shortened and
absent renal papillae and increased cleft palate.

Chronic Dietary (All Populations)	NOAEL= 10 mg/kg/day 	UFA= 10x

UFH= 10x

FQPA SF= 1x

	Chronic RfD = 0.1

mg/kg/day

cPAD = 0.1mg/kg/day	24-month oncogenicity study on CD-1 mice.

LOAEL = 50 mg/kg/day based on non-neoplastic liver effects (increased
liver weight in males and increase in liver lesions: masses/raised
areas/ swellings/nodular areas mainly).

Cancer (oral, dermal, inhalation)   	Classification: Group C, possible
human carcinogen, RfD approach for risk characterization.

Point of Departure (POD) = A data point or an estimated point that is
derived from observed dose-response data and  used to mark the beginning
of extrapolation to determine risk associated with lower environmentally
relevant human exposures.  NOAEL = no observed adverse effect level. 
LOAEL = lowest observed adverse effect level.  UF = uncertainty factor. 
UFA = extrapolation from animal to human (intraspecies).  UFH =
potential variation in sensitivity among members of the human population
(interspecies).  UFL = use of a LOAEL to extrapolate a NOAEL.  UFS = use
of a short-term study for long-term risk assessment.  UFDB = to account
for the absence of key data (i.e., lack of a critical study).  FQPA SF =
FQPA Safety Factor.  PAD = population adjusted dose (a = acute, c =
chronic).  RfD = reference dose.  MOE = margin of exposure.  LOC = level
of concern.  N/A = not applicable.

VI.	Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned
when dietary risk exceeds 100% of the PAD.  The DEEM-FCID™ analyses
estimate the dietary exposure of the U.S. population and various
population subgroups.  The results reported in Table(s) are for the
general U.S. Population, all infants (<1 year old), children 1-2,
children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49,
and adults 50+ years.  Cancer risk is determined for the general U.S.
population only.

At the 95th percentile, the acute dietary exposure (food and water) to
general US population is at 7 % of the aPAD, and the most highly exposed
subgroup, all infants <1 yrs old, is at 16 % of the aPAD.  The chronic
dietary exposure to general US population is at 7 % of the cPAD, and the
most highly exposed subgroup, Children 1-2 yrs old, is at 17 % of the
cPAD.  All the dietary risk estimates are below 100% of the PADs.

These analyses are highly conservative, Tier 1 dietary exposure
assessments.  Further refinement to the analyses could be made through
the use of anticipated residues, incorporation of percentages of crops
treated with propiconazole, and/or monitoring data that better reflect
residues at the time of consumption.  Since risk estimates are well
below HED’s level of concern, a more highly refined analysis is not
needed at this time.

Results of Acute Dietary (Food and Drinking Water) Exposure Analysis

Table 3.  Results of Acute Dietary Exposure Analysis for FOOD and Water

Population Subgroup	

aPAD (mg/kg/day)	

95th Percentile	

99th Percentile	

99.9th Percentile

Exposure (mg/kg/day)	

% aPAD	

Exposure (mg/kg/day)	

% aPAD	

Exposure (mg/kg/day)	

% aPAD

General U.S. Population	

0.3	

0.020692	

7	

0.039531	

13	

0.086579	

29

All Infants (< 1 year old)	

0.3	

0.046634	

16	

0.085813	

29	

0.180940	

60

Children 1-2 years old	

0.3	

0.046428	

15	

0.089383	

30	

0.190359	

63

Children 3-5 years old	

0.3	

0.036739	12	

0.066632	

22	

0.126248	

42

Children 6-12 years old	

0.3	

0.025988	

9	

0.044376	

15	

0.072240	

24

Youth 13-19 years old	

0.3	

0.017393	

6	

0.035380	

12	

0.061461	

21

Adults 20-49 years old	

0.3	

0.016768	

6	0.031070	

10	

0.055564	19

Adults 50+ years old	

0.3	0.012911	

4	0.023194	

8	0.045189	15

Females 13-49 years old	

0.3	

0.015986	5	0.028877	10	0.059870	20

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

Table 4.  Results of Chronic Dietary Exposure Analysis for FOOD and
Water

Population Subgroup	

cPAD

(mg/kg/day)	

Exposure (mg/kg/day)	

% cPAD

General U.S. Population	

0.1	

0.006484	

7

All Infants (< 1 year old)	

0.1	

0.015191	

15

Children 1-2 years old	

0.1	

0.016800	

17

Children 3-5 years old	

0.1	

0.013945	

14

Children 6-12 years old	

0.1	

0.009237	

9

Youth 13-19 years old	

0.1	

0.005661	

6

Adults 20-49 years old	

0.1	

0.005433	

5

Adults 50+ years old	

0.1	

0.004396	

4

Females 13-49 years old	0.1	0.005063	5

VI.	Conclusions

These Tier 1 analyses demonstrate that the requested uses for
propiconazole will not result in dietary risk estimates that exceed
HED’s level of concern for any of the regulated population subgroups,
including those comprised of infants and children.  A summary of the
dietary exposure analyses is given in Table 5.  

Table 5.  Summary of Dietary Exposure and Risk for Propiconazole FOOD
PLUS WATER.

Population Subgroup*	

Acute Dietary

(95th Percentile)	

Chronic Dietary	

Cancer

	

Dietary Exposure (mg/kg/day)	

% aPAD	

Dietary Exposure

(mg/kg/day)	

% cPAD	

Dietary Exposure

(mg/kg/day)	

Risk

General U.S. Population	

0.020692	

7	

0.006484	

7	

N/A

All Infants (< 1 year old)	

0.046634	

16	

0.015191	

15

	

Children 1-2 years old	

0.046428	

15	

0.016800	

17

	

Children 3-5 years old	

0.036739	12	

0.013945	

14

	

Children 6-12 years old	

0.025988	

9	

0.009237	

9

	

Youth 13-19 years old	

0.017393	

6	

0.005661	

6

	

Adults 20-49 years old	

0.016768	

6	

0.005433	

5

	

Adults 50+ years old	0.012911	

4	

0.004396	

4

	

Females 13-49 years old	

0.015986	5	0.005063	5

	

VII.		List of Attachments

Attachment 1. Acute Food plus Water Residue Input file.

Attachment 2. Acute Results file.

Attachment 3. Chronic Food plus Water Residue Input file.

Attachment 4. Chronic Results file.

 

Attachment 1. Acute Food plus Water Residue Input file.

Filename: C:\Documents and Settings\ydonovan\DEEM
Files\Propiconazole\acute122101newuses.R98

Chemical: Propiconazole

RfD(Chronic): .1 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .3 mg/kg bw/day  NOEL(Acute):  30 mg/kg bw/day

Date created/last modified: 07-31-2008/11:15:35/8          Program ver.
2.03

Comment: Acute for general popn - 0.3 (including females now)

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

14000030 14   Almond                             0.100000   1.000  1.000
 

14000031 14   Almond-babyfood                    0.100000   1.000  1.000
 

14000040 14   Almond, oil                        0.100000   1.000  1.000
 

14000041 14   Almond, oil-babyfood               0.100000   1.000  1.000
 

12000120 12   Apricot                            1.000000   1.000  1.000
 

12000121 12   Apricot-babyfood                   1.000000   1.000  1.000
 

12000130 12   Apricot, dried                     1.000000   6.000  1.000
 

12000140 12   Apricot, juice                     1.000000   1.000  1.000
 

12000141 12   Apricot, juice-babyfood            1.000000   1.000  1.000
 

95000230 O    Banana                             0.200000   1.000  1.000
 

95000231 O    Banana-babyfood                    0.200000   1.000  1.000
 

95000240 O    Banana, dried                      0.200000   3.900  1.000
 

95000241 O    Banana, dried-babyfood             0.200000   3.900  1.000
 

15000250 15   Barley, pearled barley             0.300000   1.000  1.000
 

15000251 15   Barley, pearled barley-babyfood    0.300000   1.000  1.000
 

15000260 15   Barley, flour                      0.300000   1.000  1.000
 

15000261 15   Barley, flour-babyfood             0.300000   1.000  1.000
 

15000270 15   Barley, bran                       0.600000   1.000  1.000
 

21000440 M    Beef, meat                         0.050000   1.000  1.000
 

21000441 M    Beef, meat-babyfood                0.050000   1.000  1.000
 

21000450 M    Beef, meat, dried                  0.050000   1.920  1.000
 

21000460 M    Beef, meat byproducts              0.050000   1.000  1.000
 

21000461 M    Beef, meat byproducts-babyfood     0.050000   1.000  1.000
 

21000470 M    Beef, fat                          0.050000   1.000  1.000
 

21000471 M    Beef,fat-babyfood                  0.050000   1.000  1.000
 

21000480 M    Beef, kidney                       2.000000   1.000  1.000
 

21000490 M    Beef, liver                        2.000000   1.000  1.000
 

21000491 M    Beef, liver-babyfood               2.000000   1.000  1.000
 

01010500 1AB  Beet, garden, roots                0.300000   1.000  1.000
 

01010501 1AB  Beet, garden, roots-babyfood       0.300000   1.000  1.000
 

02000510 2    Beet, garden, tops                 5.500000   1.000  1.000
 

01010520 1A   Beet, sugar                        0.300000   1.000  1.000
 

01010521 1A   Beet, sugar-babyfood               0.300000   1.000  1.000
 

01010530 1A   Beet, sugar, molasses              1.500000   1.000  1.000
 

01010531 1A   Beet, sugar, molasses-babyfood     1.500000   1.000  1.000
 

13010550 13A  Blackberry                         1.000000   1.000  1.000
 

13020570 13B  Blueberry                          1.000000   1.000  1.000
 

13020571 13B  Blueberry-babyfood                 1.000000   1.000  1.000
 

13010580 13A  Boysenberry                        1.000000   1.000  1.000
 

14000590 14   Brazil nut                         0.100000   1.000  1.000
 

14000680 14   Butternut                          0.100000   1.000  1.000
 

04020760 4B   Cardoon                            5.000000   1.000  1.000
 

01010780 1AB  Carrot                             0.250000   1.000  1.000
 

01010781 1AB  Carrot-babyfood                    0.250000   1.000  1.000
 

01010790 1AB  Carrot, juice                      0.250000   1.000  1.000
 

14000810 14   Cashew                             0.100000   1.000  1.000
 

04020850 4B   Celery                             5.000000   1.000  1.000
 

04020851 4B   Celery-babyfood                    5.000000   1.000  1.000
 

04020860 4B   Celery, juice                      5.000000   1.000  1.000
 

04020870 4B   Celtuce                            5.000000   1.000  1.000
 

12000900 12   Cherry                             1.000000   1.000  1.000
 

12000901 12   Cherry-babyfood                    1.000000   1.000  1.000
 

12000910 12   Cherry, juice                      1.000000   1.500  1.000
 

12000911 12   Cherry, juice-babyfood             1.000000   1.500  1.000
 

14000920 14   Chestnut                           0.100000   1.000  1.000
 

15001200 15   Corn, field, flour                 0.200000   1.000  1.000
 

15001201 15   Corn, field, flour-babyfood        0.200000   1.000  1.000
 

15001210 15   Corn, field, meal                  0.200000   1.000  1.000
 

15001211 15   Corn, field, meal-babyfood         0.200000   1.000  1.000
 

15001220 15   Corn, field, bran                  0.200000   1.000  1.000
 

15001230 15   Corn, field, starch                0.200000   1.000  1.000
 

15001231 15   Corn, field, starch-babyfood       0.200000   1.000  1.000
 

15001240 15   Corn, field, syrup                 0.200000   1.500  1.000
 

15001241 15   Corn, field, syrup-babyfood        0.200000   1.500  1.000
 

15001250 15   Corn, field, oil                   0.200000   1.000  1.000
 

15001251 15   Corn, field, oil-babyfood          0.200000   1.000  1.000
 

15001260 15   Corn, pop                          0.200000   1.000  1.000
 

15001270 15   Corn, sweet                        0.100000   1.000  1.000
 

15001271 15   Corn, sweet-babyfood               0.100000   1.000  1.000
 

95001300 O    Cranberry                          1.000000   1.000  1.000
 

95001301 O    Cranberry-babyfood                 1.000000   1.000  1.000
 

95001310 O    Cranberry, dried                   1.000000   1.000  1.000
 

95001320 O    Cranberry, juice                   1.000000   1.000  1.000
 

95001321 O    Cranberry, juice-babyfood          1.000000   1.000  1.000
 

13021360 13B  Currant                            1.000000   1.000  1.000
 

13021370 13B  Currant, dried                     1.000000   1.000  1.000
 

13011420 13A  Dewberry                           1.000000   1.000  1.000
 

13021490 13B  Elderberry                         1.000000   1.000  1.000
 

04021520 4B   Fennel, Florence                   5.000000   1.000  1.000
 

14001550 14   Filbert                            0.100000   1.000  1.000
 

14001560 14   Filbert, oil                       0.100000   1.000  1.000
 

23001690 M    Goat, meat                         0.050000   1.000  1.000
 

23001700 M    Goat, meat byproducts              0.050000   1.000  1.000
 

23001710 M    Goat, fat                          0.050000   1.000  1.000
 

23001720 M    Goat, kidney                       2.000000   1.000  1.000
 

23001730 M    Goat, liver                        2.000000   1.000  1.000
 

13021740 13B  Gooseberry                         1.000000   1.000  1.000
 

14001850 14   Hickory nut                        0.100000   1.000  1.000
 

24001890 M    Horse, meat                        0.050000   1.000  1.000
 

13021910 13B  Huckleberry                        1.000000   1.000  1.000
 

13012080 13A  Loganberry                         1.000000   1.000  1.000
 

14002130 14   Macadamia nut                      0.100000   1.000  1.000
 

27002220 D    Milk, fat                          0.050000   1.000  1.000
 

27002221 D    Milk, fat - baby food/infant for   0.050000   1.000  1.000
 

27012230 D    Milk, nonfat solids                0.050000   1.000  1.000
 

27012231 D    Milk, nonfat solids-baby food/in   0.050000   1.000  1.000
 

27022240 D    Milk, water                        0.050000   1.000  1.000
 

27022241 D    Milk, water-babyfood/infant form   0.050000   1.000  1.000
 

27032251 D    Milk, sugar (lactose)-baby food/   0.050000   1.000  1.000
 

95002280 O    Mushroom                           0.100000   1.000  1.000
 

12002300 12   Nectarine                          2.000000   1.000  1.000
 new Se

          Full comment: new Section 18 tolerance

15002310 15   Oat, bran                          0.600000   1.000  1.000
 

15002320 15   Oat, flour                         0.300000   1.000  1.000
 

15002321 15   Oat, flour-babyfood                0.300000   1.000  1.000
 

15002330 15   Oat, groats/rolled oats            0.300000   1.000  1.000
 

15002331 15   Oat, groats/rolled oats-babyfood   0.300000   1.000  1.000
 

03002370 3    Onion, dry bulb                    0.200000   1.000  1.000
 

03002371 3    Onion, dry bulb-babyfood           0.200000   1.000  1.000
 

03002380 3    Onion, dry bulb, dried             0.200000   9.000  1.000
 

03002381 3    Onion, dry bulb, dried-babyfood    0.200000   9.000  1.000
 

03002390 3    Onion, green                       9.000000   1.000  1.000
 

04012480 4A   Parsley, leaves                   13.000000   1.000  1.000
 

19012490 19A  Parsley, dried leaves             35.000000   1.000  1.000
 

19012491 19A  Parsley, dried leaves-babyfood    35.000000   1.000  1.000
 

12002600 12   Peach                              2.000000   1.000  1.000
 new Se

          Full comment: new Section 18 tolerance

12002601 12   Peach-babyfood                     2.000000   1.000  1.000
 

12002610 12   Peach, dried                       2.000000   7.000  1.000
 

12002611 12   Peach, dried-babyfood              2.000000   7.000  1.000
 

12002620 12   Peach, juice                       2.000000   1.000  1.000
 

12002621 12   Peach, juice-babyfood              2.000000   1.000  1.000
 

95002630 O    Peanut                             0.200000   1.000  1.000
 

95002640 O    Peanut, butter                     0.200000   1.890  1.000
 

95002650 O    Peanut, oil                        0.200000   1.000  1.000
 

14002690 14   Pecan                              0.100000   1.000  1.000
 

95002750 O    Peppermint                         3.500000   1.000  1.000
 

95002760 O    Peppermint, oil                    3.500000   1.000  1.000
 

95002790 O    Pineapple                          4.500000   1.000  1.000
 

95002791 O    Pineapple-babyfood                 4.500000   1.000  1.000
 

95002800 O    Pineapple, dried                   4.500000   5.000  1.000
 

95002810 O    Pineapple, juice                   4.500000   1.000  1.000
 

95002811 O    Pineapple, juice-babyfood          4.500000   1.000  1.000
 

14002820 14   Pistachio                          0.100000   1.000  1.000
 

12002850 12   Plum                               1.000000   1.000  1.000
 

12002851 12   Plum-babyfood                      1.000000   1.000  1.000
 

12002860 12   Plum, prune, fresh                 1.000000   1.000  1.000
 

12002861 12   Plum, prune, fresh-babyfood        1.000000   1.000  1.000
 

12002870 12   Plum, prune, dried                 1.000000   5.000  1.000
 

12002871 12   Plum, prune, dried-babyfood        1.000000   5.000  1.000
 

12002880 12   Plum, prune, juice                 1.000000   1.400  1.000
 

12002881 12   Plum, prune, juice-babyfood        1.000000   1.400  1.000
 

25002940 M    Pork, kidney                       0.200000   1.000  1.000
 

25002950 M    Pork, liver                        0.200000   1.000  1.000
 

13013200 13A  Raspberry                          1.000000   1.000  1.000
 

13013201 13A  Raspberry-babyfood                 1.000000   1.000  1.000
 

13013210 13A  Raspberry, juice                   1.000000   1.000  1.000
 

13013211 13A  Raspberry, juice-babyfood          1.000000   1.000  1.000
 

04023220 4B   Rhubarb                            5.000000   1.000  1.000
 

15003230 15   Rice, white                        7.000000   1.000  1.000
 

15003231 15   Rice, white-babyfood               7.000000   1.000  1.000
 

15003240 15   Rice, brown                        7.000000   1.000  1.000
 

15003241 15   Rice, brown-babyfood               7.000000   1.000  1.000
 

15003250 15   Rice, flour                        7.000000   1.000  1.000
 

15003251 15   Rice, flour-babyfood               7.000000   1.000  1.000
 

15003260 15   Rice, bran                        15.000000   1.000  1.000
 

15003261 15   Rice, bran-babyfood               15.000000   1.000  1.000
 

15003280 15   Rye, grain                         0.300000   1.000  1.000
 

15003290 15   Rye, flour                         0.300000   1.000  1.000
 

26003390 M    Sheep, meat                        0.050000   1.000  1.000
 

26003391 M    Sheep, meat-babyfood               0.050000   1.000  1.000
 

26003400 M    Sheep, meat byproducts             0.050000   1.000  1.000
 

26003410 M    Sheep, fat                         0.050000   1.000  1.000
 

26003411 M    Sheep, fat-babyfood                0.050000   1.000  1.000
 

26003420 M    Sheep, kidney                      2.000000   1.000  1.000
 

26003430 M    Sheep, liver                       2.000000   1.000  1.000
 

15003440 15   Sorghum, grain                     3.500000   1.000  1.000
 

15003450 15   Sorghum, syrup                     3.500000   1.000  1.000
 

06003470 6    Soybean, seed                      2.000000   1.000  1.000
 

06003480 6    Soybean, flour                     2.000000   1.000  1.000
 

06003481 6    Soybean, flour-babyfood            2.000000   1.000  1.000
 

06003490 6    Soybean, soy milk                  2.000000   1.000  1.000
 

06003491 6    Soybean, soy milk-babyfood or in   2.000000   1.000  1.000
 

06003500 6    Soybean, oil                       2.000000   1.000  1.000
 

06003501 6    Soybean, oil-babyfood              2.000000   1.000  1.000
 

95003520 O    Spearmint                          3.500000   1.000  1.000
 

95003530 O    Spearmint, oil                     3.500000   1.000  1.000
 

95003590 O    Strawberry                         1.300000   1.000  1.000
 

95003591 O    Strawberry-babyfood                1.300000   1.000  1.000
 

95003600 O    Strawberry, juice                  1.300000   1.000  1.000
 

04023670 4B   Swiss chard                        5.000000   1.000  1.000
 

14003910 14   Walnut                             0.100000   1.000  1.000
 

86010000 O    Water, direct, all sources         0.055800   1.000  1.000
 James 

          Full comment: James Lin memo of 7/2/2008, D347906

86020000 O    Water, indirect, all sources       0.055800   1.000  1.000
 James 

          Full comment: James Lin memo of 7/2/2008, D347906

15004010 15   Wheat, grain                       0.300000   1.000  1.000
 

15004011 15   Wheat, grain-babyfood              0.300000   1.000  1.000
 

15004020 15   Wheat, flour                       0.300000   1.000  1.000
 

15004021 15   Wheat, flour-babyfood              0.300000   1.000  1.000
 

15004030 15   Wheat, germ                        0.300000   1.000  1.000
 

15004040 15   Wheat, bran                        0.600000   1.000  1.000
 

15004050 15   Wild rice                          0.500000   1.000  1.000
 



Attachment 2. Acute Results file.

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for PROPICONAZOLE                      
(1994-98 data)

Residue file: acute122101newuses.R98              Adjustment factor #2
NOT used.

Analysis Date: 07-31-2008/11:26:28    Residue file dated:
07-31-2008/11:25:27/8

NOEL (Acute) =  30.000000 mg/kg body-wt/day

Daily totals for food and foodform consumption used.

Run Comment: "Acute for general popn - 0.3 (including females now)"

========================================================================
=======

Summary calculations (per capita):

      95th Percentile             99th Percentile             99.9th
Percentile

 Exposure  % aRfD     MOE    Exposure  % aRfD     MOE    Exposure  %
aRfD     MOE  

---------- ------- -------- ---------- ------- -------- ----------
------- --------

U.S. Population:

  0.020692    6.90    1449    0.039531   13.18     758    0.086579  
28.86     346  

All infants:

  0.046634   15.54     643    0.085813   28.60     349    0.180940  
60.31     165  

Children 1-2 yrs:

  0.046428   15.48     646    0.089383   29.79     335    0.190359  
63.45     157  

Children 3-5 yrs:

  0.036739   12.25     816    0.066632   22.21     450    0.126248  
42.08     237  

Children 6-12 yrs:

  0.025988    8.66    1154    0.044376   14.79     676    0.072240  
24.08     415  

Youth 13-19 yrs:

  0.017393    5.80    1724    0.035380   11.79     847    0.061461  
20.49     488  

Adults 20-49 yrs:

  0.016768    5.59    1789    0.031070   10.36     965    0.055564  
18.52     539  

Adults 50+ yrs:

  0.012911    4.30    2323    0.023194    7.73    1293    0.045189  
15.06     663  

Females 13-49 yrs:

  0.015986    5.33    1876    0.028877    9.63    1038    0.059870  
19.96     501  



Attachment 3. Chronic Food plus Water Residue Input file.

Filename: C:\Documents and Settings\ydonovan\DEEM
Files\Propiconazole\chronic122101newuses.R98

Chemical: Propiconazole

RfD(Chronic): .1 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .3 mg/kg bw/day  NOEL(Acute):  30 mg/kg bw/day

Date created/last modified: 07-17-2008/12:46:01/8          Program ver.
2.03

Comment: Acute for general popn - 0.3 (including females now)

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

14000030 14   Almond                             0.100000   1.000  1.000
 

14000031 14   Almond-babyfood                    0.100000   1.000  1.000
 

14000040 14   Almond, oil                        0.100000   1.000  1.000
 

14000041 14   Almond, oil-babyfood               0.100000   1.000  1.000
 

12000120 12   Apricot                            1.000000   1.000  1.000
 

12000121 12   Apricot-babyfood                   1.000000   1.000  1.000
 

12000130 12   Apricot, dried                     1.000000   6.000  1.000
 

12000140 12   Apricot, juice                     1.000000   1.000  1.000
 

12000141 12   Apricot, juice-babyfood            1.000000   1.000  1.000
 

95000230 O    Banana                             0.200000   1.000  1.000
 

95000231 O    Banana-babyfood                    0.200000   1.000  1.000
 

95000240 O    Banana, dried                      0.200000   3.900  1.000
 

95000241 O    Banana, dried-babyfood             0.200000   3.900  1.000
 

15000250 15   Barley, pearled barley             0.300000   1.000  1.000
 

15000251 15   Barley, pearled barley-babyfood    0.300000   1.000  1.000
 

15000260 15   Barley, flour                      0.300000   1.000  1.000
 

15000261 15   Barley, flour-babyfood             0.300000   1.000  1.000
 

15000270 15   Barley, bran                       0.600000   1.000  1.000
 

21000440 M    Beef, meat                         0.050000   1.000  1.000
 

21000441 M    Beef, meat-babyfood                0.050000   1.000  1.000
 

21000450 M    Beef, meat, dried                  0.050000   1.920  1.000
 

21000460 M    Beef, meat byproducts              0.050000   1.000  1.000
 

21000461 M    Beef, meat byproducts-babyfood     0.050000   1.000  1.000
 

21000470 M    Beef, fat                          0.050000   1.000  1.000
 

21000471 M    Beef,fat-babyfood                  0.050000   1.000  1.000
 

21000480 M    Beef, kidney                       2.000000   1.000  1.000
 

21000490 M    Beef, liver                        2.000000   1.000  1.000
 

21000491 M    Beef, liver-babyfood               2.000000   1.000  1.000
 

01010500 1AB  Beet, garden, roots                0.300000   1.000  1.000
 

01010501 1AB  Beet, garden, roots-babyfood       0.300000   1.000  1.000
 

02000510 2    Beet, garden, tops                 5.500000   1.000  1.000
 

01010520 1A   Beet, sugar                        0.300000   1.000  1.000
 

01010521 1A   Beet, sugar-babyfood               0.300000   1.000  1.000
 

01010530 1A   Beet, sugar, molasses              1.500000   1.000  1.000
 

01010531 1A   Beet, sugar, molasses-babyfood     1.500000   1.000  1.000
 

13010550 13A  Blackberry                         1.000000   1.000  1.000
 

13020570 13B  Blueberry                          1.000000   1.000  1.000
 

13020571 13B  Blueberry-babyfood                 1.000000   1.000  1.000
 

13010580 13A  Boysenberry                        1.000000   1.000  1.000
 

14000590 14   Brazil nut                         0.100000   1.000  1.000
 

14000680 14   Butternut                          0.100000   1.000  1.000
 

04020760 4B   Cardoon                            5.000000   1.000  1.000
 

01010780 1AB  Carrot                             0.250000   1.000  1.000
 

01010781 1AB  Carrot-babyfood                    0.250000   1.000  1.000
 

01010790 1AB  Carrot, juice                      0.250000   1.000  1.000
 

14000810 14   Cashew                             0.100000   1.000  1.000
 

04020850 4B   Celery                             5.000000   1.000  1.000
 

04020851 4B   Celery-babyfood                    5.000000   1.000  1.000
 

04020860 4B   Celery, juice                      5.000000   1.000  1.000
 

04020870 4B   Celtuce                            5.000000   1.000  1.000
 

12000900 12   Cherry                             1.000000   1.000  1.000
 

12000901 12   Cherry-babyfood                    1.000000   1.000  1.000
 

12000910 12   Cherry, juice                      1.000000   1.500  1.000
 

12000911 12   Cherry, juice-babyfood             1.000000   1.500  1.000
 

14000920 14   Chestnut                           0.100000   1.000  1.000
 

15001200 15   Corn, field, flour                 0.200000   1.000  1.000
 

15001201 15   Corn, field, flour-babyfood        0.200000   1.000  1.000
 

15001210 15   Corn, field, meal                  0.200000   1.000  1.000
 

15001211 15   Corn, field, meal-babyfood         0.200000   1.000  1.000
 

15001220 15   Corn, field, bran                  0.200000   1.000  1.000
 

15001230 15   Corn, field, starch                0.200000   1.000  1.000
 

15001231 15   Corn, field, starch-babyfood       0.200000   1.000  1.000
 

15001240 15   Corn, field, syrup                 0.200000   1.500  1.000
 

15001241 15   Corn, field, syrup-babyfood        0.200000   1.500  1.000
 

15001250 15   Corn, field, oil                   0.200000   1.000  1.000
 

15001251 15   Corn, field, oil-babyfood          0.200000   1.000  1.000
 

15001260 15   Corn, pop                          0.200000   1.000  1.000
 

15001270 15   Corn, sweet                        0.100000   1.000  1.000
 

15001271 15   Corn, sweet-babyfood               0.100000   1.000  1.000
 

95001300 O    Cranberry                          1.000000   1.000  1.000
 

95001301 O    Cranberry-babyfood                 1.000000   1.000  1.000
 

95001310 O    Cranberry, dried                   1.000000   1.000  1.000
 

95001320 O    Cranberry, juice                   1.000000   1.000  1.000
 

95001321 O    Cranberry, juice-babyfood          1.000000   1.000  1.000
 

13021360 13B  Currant                            1.000000   1.000  1.000
 

13021370 13B  Currant, dried                     1.000000   1.000  1.000
 

13011420 13A  Dewberry                           1.000000   1.000  1.000
 

13021490 13B  Elderberry                         1.000000   1.000  1.000
 

04021520 4B   Fennel, Florence                   5.000000   1.000  1.000
 

14001550 14   Filbert                            0.100000   1.000  1.000
 

14001560 14   Filbert, oil                       0.100000   1.000  1.000
 

23001690 M    Goat, meat                         0.050000   1.000  1.000
 

23001700 M    Goat, meat byproducts              0.050000   1.000  1.000
 

23001710 M    Goat, fat                          0.050000   1.000  1.000
 

23001720 M    Goat, kidney                       2.000000   1.000  1.000
 

23001730 M    Goat, liver                        2.000000   1.000  1.000
 

13021740 13B  Gooseberry                         1.000000   1.000  1.000
 

14001850 14   Hickory nut                        0.100000   1.000  1.000
 

24001890 M    Horse, meat                        0.050000   1.000  1.000
 

13021910 13B  Huckleberry                        1.000000   1.000  1.000
 

13012080 13A  Loganberry                         1.000000   1.000  1.000
 

14002130 14   Macadamia nut                      0.100000   1.000  1.000
 

27002220 D    Milk, fat                          0.050000   1.000  1.000
 

27002221 D    Milk, fat - baby food/infant for   0.050000   1.000  1.000
 

27012230 D    Milk, nonfat solids                0.050000   1.000  1.000
 

27012231 D    Milk, nonfat solids-baby food/in   0.050000   1.000  1.000
 

27022240 D    Milk, water                        0.050000   1.000  1.000
 

27022241 D    Milk, water-babyfood/infant form   0.050000   1.000  1.000
 

27032251 D    Milk, sugar (lactose)-baby food/   0.050000   1.000  1.000
 

95002280 O    Mushroom                           0.100000   1.000  1.000
 

12002300 12   Nectarine                          2.000000   1.000  1.000
 new Se

          Full comment: new Section 18 tolerance

15002310 15   Oat, bran                          0.600000   1.000  1.000
 

15002320 15   Oat, flour                         0.300000   1.000  1.000
 

15002321 15   Oat, flour-babyfood                0.300000   1.000  1.000
 

15002330 15   Oat, groats/rolled oats            0.300000   1.000  1.000
 

15002331 15   Oat, groats/rolled oats-babyfood   0.300000   1.000  1.000
 

03002370 3    Onion, dry bulb                    0.200000   1.000  1.000
 

03002371 3    Onion, dry bulb-babyfood           0.200000   1.000  1.000
 

03002380 3    Onion, dry bulb, dried             0.200000   9.000  1.000
 

03002381 3    Onion, dry bulb, dried-babyfood    0.200000   9.000  1.000
 

03002390 3    Onion, green                       9.000000   1.000  1.000
 

04012480 4A   Parsley, leaves                   13.000000   1.000  1.000
 

19012490 19A  Parsley, dried leaves             35.000000   1.000  1.000
 

19012491 19A  Parsley, dried leaves-babyfood    35.000000   1.000  1.000
 

12002600 12   Peach                              2.000000   1.000  1.000
 new Se

          Full comment: new Section 18 tolerance

12002601 12   Peach-babyfood                     2.000000   1.000  1.000
 

12002610 12   Peach, dried                       2.000000   7.000  1.000
 

12002611 12   Peach, dried-babyfood              2.000000   7.000  1.000
 

12002620 12   Peach, juice                       2.000000   1.000  1.000
 

12002621 12   Peach, juice-babyfood              2.000000   1.000  1.000
 

95002630 O    Peanut                             0.200000   1.000  1.000
 

95002640 O    Peanut, butter                     0.200000   1.890  1.000
 

95002650 O    Peanut, oil                        0.200000   1.000  1.000
 

14002690 14   Pecan                              0.100000   1.000  1.000
 

95002750 O    Peppermint                         3.500000   1.000  1.000
 

95002760 O    Peppermint, oil                    3.500000   1.000  1.000
 

95002790 O    Pineapple                          4.500000   1.000  1.000
 

95002791 O    Pineapple-babyfood                 4.500000   1.000  1.000
 

95002800 O    Pineapple, dried                   4.500000   5.000  1.000
 

95002810 O    Pineapple, juice                   4.500000   1.000  1.000
 

95002811 O    Pineapple, juice-babyfood          4.500000   1.000  1.000
 

14002820 14   Pistachio                          0.100000   1.000  1.000
 

12002850 12   Plum                               1.000000   1.000  1.000
 

12002851 12   Plum-babyfood                      1.000000   1.000  1.000
 

12002860 12   Plum, prune, fresh                 1.000000   1.000  1.000
 

12002861 12   Plum, prune, fresh-babyfood        1.000000   1.000  1.000
 

12002870 12   Plum, prune, dried                 1.000000   5.000  1.000
 

12002871 12   Plum, prune, dried-babyfood        1.000000   5.000  1.000
 

12002880 12   Plum, prune, juice                 1.000000   1.400  1.000
 

12002881 12   Plum, prune, juice-babyfood        1.000000   1.400  1.000
 

25002940 M    Pork, kidney                       0.200000   1.000  1.000
 

25002950 M    Pork, liver                        0.200000   1.000  1.000
 

13013200 13A  Raspberry                          1.000000   1.000  1.000
 

13013201 13A  Raspberry-babyfood                 1.000000   1.000  1.000
 

13013210 13A  Raspberry, juice                   1.000000   1.000  1.000
 

13013211 13A  Raspberry, juice-babyfood          1.000000   1.000  1.000
 

04023220 4B   Rhubarb                            5.000000   1.000  1.000
 

15003230 15   Rice, white                        7.000000   1.000  1.000
 

15003231 15   Rice, white-babyfood               7.000000   1.000  1.000
 

15003240 15   Rice, brown                        7.000000   1.000  1.000
 

15003241 15   Rice, brown-babyfood               7.000000   1.000  1.000
 

15003250 15   Rice, flour                        7.000000   1.000  1.000
 

15003251 15   Rice, flour-babyfood               7.000000   1.000  1.000
 

15003260 15   Rice, bran                        15.000000   1.000  1.000
 

15003261 15   Rice, bran-babyfood               15.000000   1.000  1.000
 

15003280 15   Rye, grain                         0.300000   1.000  1.000
 

15003290 15   Rye, flour                         0.300000   1.000  1.000
 

26003390 M    Sheep, meat                        0.050000   1.000  1.000
 

26003391 M    Sheep, meat-babyfood               0.050000   1.000  1.000
 

26003400 M    Sheep, meat byproducts             0.050000   1.000  1.000
 

26003410 M    Sheep, fat                         0.050000   1.000  1.000
 

26003411 M    Sheep, fat-babyfood                0.050000   1.000  1.000
 

26003420 M    Sheep, kidney                      2.000000   1.000  1.000
 

26003430 M    Sheep, liver                       2.000000   1.000  1.000
 

15003440 15   Sorghum, grain                     3.500000   1.000  1.000
 

15003450 15   Sorghum, syrup                     3.500000   1.000  1.000
 

06003470 6    Soybean, seed                      2.000000   1.000  1.000
 

06003480 6    Soybean, flour                     2.000000   1.000  1.000
 

06003481 6    Soybean, flour-babyfood            2.000000   1.000  1.000
 

06003490 6    Soybean, soy milk                  2.000000   1.000  1.000
 

06003491 6    Soybean, soy milk-babyfood or in   2.000000   1.000  1.000
 

06003500 6    Soybean, oil                       2.000000   1.000  1.000
 

06003501 6    Soybean, oil-babyfood              2.000000   1.000  1.000
 

95003520 O    Spearmint                          3.500000   1.000  1.000
 

95003530 O    Spearmint, oil                     3.500000   1.000  1.000
 

95003590 O    Strawberry                         1.300000   1.000  1.000
 

95003591 O    Strawberry-babyfood                1.300000   1.000  1.000
 

95003600 O    Strawberry, juice                  1.300000   1.000  1.000
 

04023670 4B   Swiss chard                        5.000000   1.000  1.000
 

14003910 14   Walnut                             0.100000   1.000  1.000
 

86010000 O    Water, direct, all sources         0.022000   1.000  1.000
 James 

          Full comment: James Lin memo of 7/2/2008, D347906

86020000 O    Water, indirect, all sources       0.022000   1.000  1.000
 James 

          Full comment: James Lin memo of 7/2/2008, D347906

15004010 15   Wheat, grain                       0.300000   1.000  1.000
 

15004011 15   Wheat, grain-babyfood              0.300000   1.000  1.000
 

15004020 15   Wheat, flour                       0.300000   1.000  1.000
 

15004021 15   Wheat, flour-babyfood              0.300000   1.000  1.000
 

15004030 15   Wheat, germ                        0.300000   1.000  1.000
 

15004040 15   Wheat, bran                        0.600000   1.000  1.000
 

15004050 15   Wild rice                          0.500000   1.000  1.000
 

Attachment 4. Chronic Results file.

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for PROPICONAZOLE                    (1994-98
data)

Residue file name: C:\Documents and Settings\ydonovan\DEEM
Files\Propiconazole\chronic122101newuses.R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 07-31-2008/11:21:03     Residue file dated:
07-31-2008/11:20:32/8

Reference dose (RfD, Chronic) = .1 mg/kg bw/day

COMMENT 1: Acute for general popn - 0.3 (including females now)

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.006484                
6.5%

U.S. Population (spring season)             0.006590                
6.6%

U.S. Population (summer season)             0.006741                
6.7%

U.S. Population (autumn season)             0.006226                
6.2%

U.S. Population (winter season)             0.006388                
6.4%

Northeast region                            0.006792                
6.8%

Midwest region                              0.006059                
6.1%

Southern region                             0.005775                
5.8%

Western region                              0.007786                
7.8%

Hispanics                                   0.008493                
8.5%

Non-hispanic whites                         0.005724                
5.7%

Non-hispanic blacks                         0.006368                
6.4%

Non-hisp/non-white/non-black                0.014496               
14.5%

All infants (< 1 year)                      0.015191               
15.2%

Nursing infants                             0.007881                
7.9%

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Non-nursing infants                         0.017965               
18.0%

Children 1-6  yrs                           0.014527               
14.5%

Children 7-12 yrs                           0.008789                
8.8%

Females 13-19 (not preg or nursing)         0.004927                
4.9%

Females 20+ (not preg or nursing)           0.004673                
4.7%

Females 13-50 yrs                           0.005470                
5.5%

Females 13+ (preg/not nursing)              0.006721                
6.7%

Females 13+ (nursing)                       0.006966                
7.0%

Males 13-19 yrs                             0.006342                
6.3%

Males 20+ yrs                               0.005409                
5.4%

Seniors 55+                                 0.004332                
4.3%

Children 1-2 yrs                            0.016800               
16.8%

Children 3-5 yrs                            0.013945               
13.9%

Children 6-12 yrs                           0.009237                
9.2%

Youth 13-19 yrs                             0.005661                
5.7%

Adults 20-49 yrs                            0.005433                
5.4%

Adults 50+ yrs                              0.004396                
4.4%

Females 13-49 yrs                           0.005063                
5.1%

 Propiconazole	Dietary Exposure and Risk Assessment	DP Number: D355821	

PC Code:  122101		

________________________________________________________________________
______________

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