Document ID: EPA-HQ-OPP-2009-0813-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2012-09-26T04:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                                       
                            WASHINGTON, D.C.  20460
                                          								OFFICE OF CHEMICAL SAFETY AND
                                                                                             
                                                  OFFICE OF CHEMICAL SAFETY AND
                                                                                              	 POLLUTION PREVENTION
                                                                               
MEMORANDUM

Date:  		19-JUN-2012

SUBJECT:	Glufosinate Ammonium.  Update of the Revised Acute and Chronic Aggregate Dietary (Food and Drinking Water) Exposure Assessment in Support of the Petition Proposing Tolerances for Residues of Glufosinate Ammonium in/on Citrus Fruits (Crop Group 10), Pome Fruits (Crop Group 11), Stone Fruits (Crop Group 12), Olives, and Sweet Corn.

PC Code:  
128850
DP Barcode:
D402741
Decision No.:
402155
Registration No.:
NA
Petition No.:
9E7604 & 9F7655
Regulatory Action:
Section 3
Assessment Type:
Dietary
Case No.:
7224
TXR No.:
NA
CAS No.:
77182-82-2
MRID No.:
NA
40 CFR:
§180.473

FROM:	William H. Donovan, Ph.D., Chemist 
            Risk Assessment Branch V					
            Health Effects Division (HED) (7509P)
            
THROUGH:    Douglas Dotson, Ph.D., Chemist
            Kristin Rury, MPH, Biologist
		Dietary Exposure Science Advisory Council (DESAC)
		Health Effects Division (HED) (7509P)
            
TO:	Kathryn Montague, RM Team 23
      Sidney Jackson/Barbara Madden, RM Team 05
		Registration Division (RD) (7505P)

      and

      Katie Weyrauch, Risk Manager Reviewer
      Tom Myers, Risk Manager  
      Pesticide Re-Evaluation Division (PRD) (7508P)

	
Executive Summary

The purpose of this memorandum is to report the results of revised acute and chronic aggregate dietary (food + drinking water) exposure analyses for the herbicide glufosinate ammonium, including all currently registered uses and the proposed uses.  Revisions were made to the most recent dietary exposure analysis for glufosinate ammonium (D384486, W. Donovan, 01-DEC-2010) to include updated estimated drinking water concentrations (EDWCs) provided by EFED (D387412, C. Peck, 30-MAY-2012).  In these analyses, the acute and chronic dietary exposure and risk estimates resulting from food and water intake were determined for the general U.S. population and various population subgroups. 

Acute and chronic dietary risk assessments were conducted using the Dietary Exposure Evaluation Model DEEM-FCID(TM), Version 3.10, which uses food consumption data from the U.S. Department of Agriculture's National Health and Nutrition Examination Survey/"What We Eat in America" (NHANES/WWEIA) dietary survey conducted in 2003-2008.  These analyses were performed to support a Section 3 request for use of glufosinate ammonium in/on Citrus Fruits (Crop Group 10), Pome Fruits (Crop Group 11), Stone Fruits (Crop Group 12), olives, and sweet corn. 

 Acute Dietary (Food + Drinking Water) Exposure Results and Characterization
HED recently determined the doses and endpoints for use in human health risk assessments for glufosinate ammonium taking into account all available toxicity studies.  An endpoint was identified for assessing acute dietary exposure for only the female 13-49 years old population subgroup; therefore, no acute dietary risk assessment was performed for any other population subgroups.  Making use of tolerance level residues, default processing factors and 100% crop treated (% CT) assumptions, an unrefined acute dietary analysis (food and drinking water) for glufosinate ammonium showed that the females 13-49 year old population subgroup occupied 39% of the acute population adjusted dose (aPAD).  

Chronic Dietary (Food + Drinking Water) Exposure Results and Characterization
The chronic dietary exposure assessment for glufosinate ammonium is refined using anticipated residues based on average field trial residue for crops as well as livestock commodities. Percent crop treated information and processing factors, where available, were also used in the assessment. 

At an EDWC of 95 ppb (based on the rice use), the chronic dietary risk estimates are below HED's level of concern (i.e. <100% of the chronic population adjusted doses (cPAD)) for all population subgroups.  The highest exposed population subgroup was all infants (<1 year old) at  98% of the cPAD, and the general US population occupied 39% of the cPAD.  Potential residues in drinking water account for most of the exposure.

Cancer Exposure Results and Characterization

HED classified glufosinate ammonium as "not likely to be carcinogenic to humans" based on the absence of significant tumor increases in two adequate rodent carcinogenicity studies; therefore, no human cancer risk assessment was performed.  

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the population adjusted dose (PAD).  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.  

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  "Available Information on Assessing Exposure from Pesticides, A User's Guide," 6/21/2000, web link:  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (8/20/99).

II.	Residue Information

Tolerances:  Permanent tolerances are established for residues of glufosinate ammonium in/on a variety of commodities at levels ranging from 0.05 ppm in/on grape to 25 ppm in/on aspirated grain fractions [40 CFR §180.473(a)].  Also, rotational crop tolerances are listed under 40 CFR §180.473(d).  However, with the exception of teosinte and triticale, these tolerances are limited to livestock feedstuffs, and are accounted for in the dietary burden calculation for livestock.  Triticale is included directly in the dietary analysis; teosinte is not included in DEEM.

Residue of Concern:  HED previously concluded that the residues of concern for tolerance enforcement and risk assessment for both plant and livestock commodities are glufosinate ammonium, N-acetyl-glufosinate (HOE 099730), and 3-hydoxymethylphosphinyl-propionic acid (MPP or HOE 061517) (D282757, T. Bloem, 09-MAY-2002).  As metabolism studies are available for a variety of nontransgenic crops (corn, soybean, apple, and lettuce) and transgenic crops (corn, soybean, sugar beet, canola, and rice), the results from these metabolism studies may be translated to pome fruit, stone fruit, citrus fruit, olive, and sweet corn.  

For drinking water, the residue of concern is glufosinate ammonium.  MPP (HOE 061517) is likely less toxic than the parent compound and should not be aggregated with the parent.  If MPP EDWCs are not significantly greater than those for glufosinate (>4-5X), the risk assessment for the parent will be protective of any toxicity associated with exposure to MPP in drinking water, and a quantitative risk assessment for MPP will not be required (D397644, I. Negron-Encarnacion, 29-MAR-2012).  Thus, EFED provided EDWC estimates for both glufosinate ammonium and MPP (Section III).

Residue Data Used for Acute Assessment:  Tolerance level residues were used for the acute analysis, along with default processing factors, and 100% CT assumptions (unrefined analysis).  The following recommended tolerance levels were used for the proposed new use crops:  citrus fruit, 0.15 ppm; pome fruit, 0.25 ppm; stone fruit, 0.25 ppm; olive, 0.15 ppm; and sweet corn, 0.25 ppm (D372625, I. Negron-Encarnacion, 31-AUG-2010).
 
Residue Data Used for Chronic Assessment:  The DEEM-FCID chronic analysis was performed using anticipated residues (ARs) derived from average field trial residue levels, experimentally determined processing factors, and updated % CT information as summarized in Table 1.  For commodities bearing no detectable residues in the field trials (e.g., tree nuts, grapes, apples, citrus, olives, peaches and nectarines), the anticipated residue was taken to be (1/2) the tolerance level or recommended tolerance level.  This is a conservative estimate of the average residue level, but provides a degree of refinement beyond use of the full tolerance level.  See Attachment 5 for dietary burden calculations (from D372625, I. Negron-Encarnacion, 31-AUG-2010) and derivation of the AR values for meat, milk, poultry and egg (MMPE) commodities.  A search of the USDA PDP database showed no results for glufosinate ammonium for any commodity within the last five years.  Therefore, neither fish nor shellfish were included in the present analyses.

Anticipated Residues and Processing Factors:  

Table 1.  Anticipated Residues and Processing Factors Used in Chronic Dietary Analysis.
Commodity
Residue
Processing Factor
Reference
Beet, sugar
0.24
0.10

D257628, T. Bloem, 9-JUL-1999
Beet, sugar, molasses
0.24
6.8

Potato, chip
0.19
2.3

Potato, dry and flour
0.19
3.0

Potato, tuber
0.19
1.0

Soybean (all commodities except oil)
0.77
1.0
D211531, M. Rodriguez, 7-MAR-1996
Soybean, oil
0.77
0.75
D211531, M. Rodriguez, 7-MAR-1996
Citrus Fruit (CG 10)
Incl. juice, oil
0.075
1
(1/2) recommended tolerance level; 
47915701.der (residue)
47915706.der (PF)
Apple  (except juice)
Crabapple
0.025
Apple, dried 8.0
(1/2) tolerance level; Default PF
Apple juice
0.025
1
PP8F3607, J. Garbus, 14-OCT-1988
Pear (except juice)
0.155
Pear, dried 6.25
47915702.der (residue); Default PF
Pear juice
0.155
1
47915702.der (residue)
Loquat, quince
0.155
1
47915702.der (residue); Default PF
Cherry (except juice), apricot 
0.156
1
47915703.der (residue)
Cherry juice
0.156
1.5
Default PF
Apricot, dried
0.156
6
Default PF
Peach and nectarine
0.075
1
(1/2) recommended tolerance level; 
47915705.der (residue)
Peach, dried
0.075
7.0
Default PF
Plum (except juice)
0.153
1.8 ( dried prune)
47915703.der (residue); 47915707.der (PF)
Plum  -  prune juice
0.153
1.4
Default PF
Bushberry subgroup 13B
0.055
1
D271110, T. Bloem, 20-JUN-2002
Tree Nuts CG 14
0.05
1
(1/2) tolerance level; default PF
Corn, field (all commodities except syrup)
0.05
1
D211531, M. Rodriguez, 7-MAR-1996
Corn, field, syrup
0.05
1.5
Default PF
Corn, sweet
0.11
1
47828201.der &
47828202.der
Rice (all commodities except bran)
0.20
1.3
45204406.der (residues)
45204408.der (PF)
Rice, bran
0.20
0.9
45204408.der (PF)
Triticale, flour
0.20
1
(1/2) tolerance level; default PF
Rapeseed, oil
0.20
1
(1/2) tolerance level; default PF
Beef*, meat
0.0059
1

See Attachment 5
Beef*, meat, dried
0.0059
1.92

Beef*, meat byproducts
0.96
1

Beef*, fat
0.065
1

Beef*, kidney
0.30
1

Beef*, liver
0.96
1

Pork, meat
0.00059
1

Pork, skin
0.096
1

Pork, meat byproducts
0.096
1

Pork, fat
0.0065
1

Pork, kidney
0.03
1

Pork, liver
0.096
1

Milk (all fractions)
0.0068
1

Meat, game
0.0059
1

Rabbit, meat
0.0059
1

Chicken**, meat
0.0071
1

Chicken**, liver
0.014
1

Chicken**, meat byproducts
0.046
1

Chicken**, fat
0.0071
1

Chicken**, skin
0.0071
1

Egg (all fractions)
0.0071
1

Water
0.095 (rice)
1
D387412, C. Peck, 30-MAY-2012
Banana/plantain
0.08
1
D172878, M. Rodriguez
Banana/plantain, dried
0.08
3.9
Default PF
Cottonseed, oil
1.12
0.01
45089303.der (residues)
45089302.der (PF)
Grape (all except raisin)
0.025
1
(1/2) tolerance level; default PF
Juice PF:  PP8F3607, J. Garbus, 14-OCT-1988
Grape, raisin
0.025
1
PP8F3607, J. Garbus, 14-OCT-1988 (PF)
Olive
0.075
1
(1/2) recommended tolerance level; 
47915704.der
Olive oil
0.075
0.6
47915708.der
   *Same for Goat, Horse, and Sheep
   **Same for Turkey and Poultry
   
Percent Crop Treated:  A Screening Level Usage Analysis (SLUA) for glufosinate ammonium was provided by BEAD for an analysis run on 19-MAR-2012 (see Attachment 6).  The average % CT values used for estimating chronic dietary exposures are listed in Table 2.  One hundred percent crop treated values were used for all proposed new uses since no projected percent crop treated values were provided.  The acute analysis was unrefined, assuming 100% CT for all commodities.
   
   Table 2.  Average percent crop treated values used in the chronic dietary analysis.
Crop
Avg % CT
Crop
Avg %CT
Almond
15
Walnut
10
Blueberry
5
Canola/Rapeseed
25
Corn, field
5
Cotton
5
Grape
15
Filbert
10
Pecan
1
Pistachio
20
Potato
10
Rice
1
Soybean
1

III.	Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by EFED (DP 387412, C. Peck, 5/30/2012) and incorporated directly into the dietary assessment.  Water residues were incorporated in the DEEM-FCID into the food categories "water, direct, all sources" and "water, indirect, all sources."   

EFED estimated acute EDWCs for glufosinate-ammonium and MPP using the refined Tier I Rice Model and Pesticide Flooded Application Model (PFAM) [version 0.70] without the index reservoir.  To estimate chronic EDWCs, the acute concentrations from PFAM without the index reservoir were allowed to degrade over a 365-day period, using the aerobic aquatic degradation half-lives, and the average concentration over the one-year period was calculated.  Using this method, chronic values are approximately 76% and 3% lower than the acute values for glufosinate-ammonium and MPP, respectively.  

Previous analyses from EFED demonstrated that the maximum acute and chronic EDWCs for glufosinate ammonium arise from the rice uses; these values being nearly an order of magnitude higher than the values from any other crop use of glufosinate ammonium (DP 372624, C. Peck, 6/22/2010 & DP 381992, C. Peck, 10/20/2010).  Thus, EFED conducted a comprehensive refinement of the drinking water assessment for the rice use of glufosinate ammonium, with the expectation that the resulting values should be protective of other uses.  

Table 3 summarizes the PFAM EDWCs for glufosinate ammonium and MPP based on the rice use patterns, as provided by EFED.  Most of the application scenarios result in lower values for MPP than for glufosinate ammonium, although the maximum chronic EDWC for MPP is approximately 2x higher than the corresponding value for glufosinate ammonium.  Because glufosinate ammonium is considerably more toxic than MPP, and these compounds have sufficient differences in toxicity that precludes aggregation, parent EDWCs are protective of MPP EDWCs.  Accordingly, the acute and chronic dietary analyses included the highest glufosinate ammonium EDWCs of 390 and 95 ppb, respectively.

Table 3.  EDWCs for glufosinate-ammonium use on rice derived using PFAM (maximum values appear in bold)
Use rate, Number of apps, retreatment interval, water holding period, application timing
                                  Acute EDWC 
                                    (ug/L)
                            Chronic EDWC[1] (ug/L)

                                     4"
                                     8"
                                     4"
                                     8"
                             Glufosinate-ammonium
1.46 lbs ai/acre, 1, NA, 7 days, dry
                                      173
                                      86
                                      42
                                      21
0.73 lbs ai/acre, 2, 10, 30, dry and flooded[2]
                                      NA
                                      320
                                      NA
                                      78
0.73 lbs ai/acre, 2, 10, 55, dry and flooded[2]
                                      390
                                      NA
                                      95
                                      NA
0.89 lbs ai/acre, 1, NA, 7 days, dry
                                      106
                                      53
                                      26
                                      13
0.66 lbs ai/acre, 1, NA, 7 days, dry
                                      74
                                      38
                                      18
                                       9
0.44 lbs ai/acre, 2, 10 days, 7 days, dry
                                      88
                                      45
                                      22
                                      11
0.44 lbs ai/acre, 2, 10 days,7 days, flooded
                                      NA
                                      375
                                      NA
                                      92
                                      MPP
1.46 lbs ai/acre, 1, NA, 7 days, dry
                                      5.7
                                      2.9
                                      5.5
                                      2.8
0.73 lbs ai/acre, 2, 10, 30, dry and flooded[2]
                                      NA
                                      88
                                      NA
                                      85
0.73 lbs ai/acre, 2, 10, 55, dry and flooded[2]
                                      183
                                      NA
                                      177
                                      NA
0.89 lbs ai/acre, 1, NA, 7 days, dry
                                      3.5
                                      1.8
                                      3.4
                                      1.7
0.66 lbs ai/acre, 1, NA, 7 days, dry
                                      2.2
                                      1.1
                                      2.1
                                      1.1
0.44 lbs ai/acre, 2, 10 days, 7 days, dry
                                      3.0
                                      1.5
                                      2.9
                                      1.5
0.44 lbs ai/acre, 2, 10 days,7 days, flooded
                                      NA
                                      45
                                      NA
                                      44
1. Chronic EDWC calculated by taking acute EDWC and allowing it to degrade for 365 days, using the aerobic aquatic degradation half-life, and then taking the average value over the 365-day period.
2. For this scenario the first application is made to a dry field, while the second application is made to a flooded field.
NA  -  not allowed.

IV.	DEEM-FCID(TM) Program and Consumption Information

Glufosinate ammonium acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM-FCID(TM), Version 3.10 which incorporates consumption data from USDA's National Health and Nutrition Examination Survey/"What We Eat in America" (NHANES/WWEIA) dietary survey conducted in 2003-2008.  The 2003-2008 data are based on the reported consumption of individuals over two non-consecutive survey days.  Foods "as consumed" (e.g., apple pie) are linked to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events.  Based on analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate.  The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure.  Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD.  This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an individual-by-individual basis.  The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or "matched" in multiple random pairings with residue values and then summed in a probabilistic assessment.  The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis.  In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis.  However, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.

V.	Toxicological Information

In a meeting held 10-JUN-2010, the Toxicology Science Advisory Council (ToxSAC) updated the glufosinate ammonium doses and endpoints (J. Kidwell, Glufosinate Ammonium ToxSAC Report, 29-JUL-2010).   

No endpoint was identified in the toxicological database to estimate risk to the general population from a single dose administration of glufosinate ammonium.  However, an acute dietary endpoint for females 13-50 years old was selected based on fetal deaths in the developmental toxicity study in rabbits, resulting in an aPAD of 0.063 mg/kg.  For chronic dietary exposure, a weight of evidence approach from several studies was used to select a NOAEL of 6 mg/kg/day together with a total uncertainty factor of 1000x.  HED classified glufosinate ammonium as "not likely to be carcinogenic to humans." As such, a cancer dietary risk assessment is not warranted.

The doses relevant to dietary exposure are summarized in Table 4, below.

Table 4.  Summary of Toxicological Doses and Endpoints for Glufosinate Ammonium for Use in Dietary Risk Assessments
Exposure/
Scenario
                              Point of Departure
                                 Uncertainty/
                              FQPA Safety Factors
                RfD, PAD, Level of Concern for Risk Assessment
                        Study and Toxicological Effects
Acute Dietary (Females 13-50 only)
NOAEL = 6.3 mg/kg
UFA=10X
UFH=10X
FQPA SF=1X

Acute RfD =0.063
mg/kg/day

aPAD = 0.063 mg/kg
Developmental Toxicity Study in Rabbits
LOAEL = 20 mg/kg/day based on increased fetal death.
Acute Dietary (General Population including infants and children)

NA

NA

NA
No endpoint attributable to a single exposure was identified for the general population, including infants and children.
Chronic Dietary (All Populations)
NOAEL= 6.0
mg/kg/day
UFA= 10x
UFH=10x
UFS = 10x
FQPA SF= 1x
Total UF = 1000 
Chronic RfD =0.006
mg/kg/day

cPAD =0.006
mg/kg/day
"Weight of Evidence" approach from 4 studies, including DNT.
LOAEL is based on brain glutamine synthetase inhibition, alterations in the electrocardiogram, and changes in brain morphometry at PND 72.
Cancer (oral, dermal, inhalation)
Classification:  "Not likely to be Carcinogenic to Humans" based on the absence of significant tumor increases in two adequate rodent carcinogenicity studies.
Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and  used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures.  NOAEL = no observed adverse effect level.  LOAEL = lowest observed adverse effect level.  UF = uncertainty factor.  UFA = extrapolation from animal to human (interspecies).  UFH = potential variation in sensitivity among members of the human population (intraspecies). UFS  = use of a short-term study for long-term risk assessment.  FQPA SF= FQPA Safety Factor.  PAD = population adjusted dose (a = acute, c = chronic).  RfD = reference dose.  N/A = not applicable.  

VI.	Results/Discussion 

As stated above, for acute and chronic dietary assessments, HED is concerned when dietary risk exceeds 100% of the PAD.  The DEEM-FCID analyses estimate the dietary exposure of the US population and various population subgroups.  The results reported in Table 5 (below) are for the general US population (total), all infants <1, children 1-2, children 3-5, children 6-12, youths 13-19, females 13-49, adults 20-49, and adults 50+ years old for chronic exposure; while for acute exposure only the female 13-49 years old population subgroup is reported.  

Results of Acute Dietary Exposure Analysis:  An unrefined acute dietary risk assessment for glufosinate ammonium at the EDWC of 390 ppb showed that acute dietary risk estimates are below HED's level of concern (i.e. <100% aPAD) for females 13-49 years old (39% aPAD).  

Results of Chronic Dietary Exposure Analysis:  The chronic dietary risk assessment for glufosinate ammonium at the EDWC of 95 ppb showed that chronic dietary risk estimates are below HED's level of concern (i.e. <100% cPAD) for all population subgroups; in particular, All infants (<1 year old), the highest exposed population subgroup (98% of the cPAD), and the US Population (39% of the cPAD).

The results of the dietary exposure analyses are reported in Table 5.

Table 5.  Summary of Dietary Exposure and Risk for Glufosinate Ammonium [Acute EDWC of 390 ppb, Chronic EDWC of 95 ppb].  
                            Population Subgroup[1]
                         DEEM Acute Dietary Analysis,
                               95[th] Percentile
                         DEEM Chronic Dietary Analysis
                                       
                             Exposure (mg/kg/day)
                                    % aPAD
                             Exposure (mg/kg/day)
                                    % cPAD
General U.S. Population

                                     NA[2]

                                     NA[2]
                                   0.002324
                                      39
All Infants (< 1 year old)
                                       
                                       
                                   0.005887
                                      98
Children 1-2 years old
                                       
                                       
                                   0.004387
                                      73
Children 3-5 years old
                                       
                                       
                                   0.003447
                                      57
Children 6-12 years old
                                       
                                       
                                   0.002261
                                      38
Youth 13-19 years old
                                       
                                       
                                   0.001706
                                      28
Adults 20-49 years old
                                       
                                       
                                   0.002203
                                      37
Adults 50-99 years old
                                       
                                       
                                   0.002202
                                      37
Females 13-49 years old
                                   0.024401
                                      39
                                   0.002195
                                      37
[1] Values for the population with the highest risk for each type of risk assessment are bolded.  
[2] NA = Not Applicable; no acute dietary endpoint was identified for these population subgroups.

VII.	Characterization of Inputs/Outputs

The acute dietary exposure assessment for glufosinate ammonium is unrefined, making use of tolerance level residues and 100% crop treated assumptions for all crops and livestock commodities.  This conservative analysis proved adequate, as the only relevant population subgroup, females 13-49 years old, occupied 39% aPAD.

The chronic dietary exposure assessment for glufosinate ammonium is refined using anticipated residues based on average field trial residue levels for plant raw agricultural commodities (RACs), % CT information where available, and experimentally-determined processing factors.  Additionally, ARs in livestock commodities were calculated assuming dietary burdens computed from average field trial residue levels in the feed items together with a reasonably balanced diet as specified in the most recent guidance document (Table 1 Feedstuffs (June 2008)).  The assessment could be further refined if projected percent crop treated information became available for the proposed new crop uses. 

 

 VIII.		Conclusions
 
The primary contributor to dietary exposure is drinking water.  For the acute exposure scenario, females 13-49 years old occupied 39% aPAD, and are below HED's level of concern using an unrefined analysis.  When using chronic EDWC levels determined by EFED based on the rice use, risk levels below HED's level of concern are calculated for the chronic exposure scenario for all population subgroups.  The highest exposed population subgroup, all infants (<1 year old), results in a % cPAD value of 98, while the US Population occupies 39% cPAD.  

IX.	List of Attachments
 
 Attachment 1:  Acute Food plus Water Residue Input File at an EDWC of 390 ppb 
 Attachment 2:  Acute Results File at an EDWC of 390 ppb 
 Attachment 3:  Chronic Food plus Water Residue Input File at an EDWC of 95 ppb 
 Attachment 4:  Chronic Results File at an EDWC of 95 ppb 
 Attachment 5:  Dietary Burden and Livestock AR Calculations for Glufosinate Ammonium
 Attachment 6:	 Glufosinate Ammonium SLUA dated 19-MAR-2012
 
 
Attachment 1:  Acute Food plus Water Residue Input File at an EDWC of 390 ppb

Filename: C:\Documents and Settings\wdonovan\My Documents\CalendexWWEIAFCID\128850a.R08
Chemical: glufosinate ammonium
RfD(Chronic): .006 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day
RfD(Acute): .063 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day
Date created/last modified: 06-19-2012/08:02:29            Program ver. 3.10
Comment: acute EDWC 390 ppb 30may12
--------------------------------------------------------------------------------
   EPA     Crop                                   Def Res     Adj.Factors   Comment
   Code     Grp  Commodity Name                    (ppm)       #1    #2   
---------- ---- -------------------------------  ----------  ------ ------  -------
0101052000 1A   Beet, sugar                        0.900000   1.000  1.000  
0101052001 1A   Beet, sugar-babyfood               0.900000   1.000  1.000  
0101053000 1A   Beet, sugar, molasses              5.000000   1.000  1.000  
0101053001 1A   Beet, sugar, molasses-babyfood     5.000000   1.000  1.000  
0103296000 1C   Potato, chips                      1.600000   1.000  1.000  
0103297000 1C   Potato, dry (granules/ flakes)     2.000000   1.000  1.000  
0103297001 1C   Potato, dry (granules/ flakes)-b   2.000000   1.000  1.000  
0103298000 1C   Potato, flour                      2.000000   1.000  1.000  
0103298001 1C   Potato, flour-babyfood             2.000000   1.000  1.000  
0103299000 1C   Potato, tuber, w/peel              0.800000   1.000  1.000  
0103299001 1C   Potato, tuber, w/peel-babyfood     0.800000   1.000  1.000  
0103300000 1C   Potato, tuber, w/o peel            0.800000   1.000  1.000  
0103300001 1C   Potato, tuber, w/o peel-babyfood   0.800000   1.000  1.000  
0600347000 6    Soybean, seed                      2.000000   1.000  1.000  
0600349000 6    Soybean, soy milk                  2.000000   1.000  1.000  
0600349001 6    Soybean, soy milk-babyfood or in   2.000000   1.000  1.000  
0600350000 6    Soybean, oil                       2.000000   1.000  1.000  
0600350001 6    Soybean, oil-babyfood              2.000000   1.000  1.000  
0603348000 6C   Soybean, flour                     2.000000   1.000  1.000  
0603348001 6C   Soybean, flour-babyfood            2.000000   1.000  1.000  
1001106000 10A  Citron                             0.150000   1.000  1.000  
1001107000 10A  Citrus hybrids                     0.150000   1.000  1.000  
1001108000 10A  Citrus, oil                        0.150000   1.000  1.000  
1001240000 10A  Orange                             0.150000   1.000  1.000  
1001241000 10A  Orange, juice                      0.150000   1.800  1.000  
1001241001 10A  Orange, juice-babyfood             0.150000   1.800  1.000  
1001242000 10A  Orange, peel                       0.150000   1.000  1.000  
1001369000 10A  Tangerine                          0.150000   1.000  1.000  
1001370000 10A  Tangerine, juice                   0.150000   2.300  1.000  
1002197000 10B  Kumquat                            0.150000   1.000  1.000  
1002199000 10B  Lemon                              0.150000   1.000  1.000  
1002200000 10B  Lemon, juice                       0.150000   2.000  1.000  
1002200001 10B  Lemon, juice-babyfood              0.150000   2.000  1.000  
1002201000 10B  Lemon, peel                        0.150000   1.000  1.000  
1002206000 10B  Lime                               0.150000   1.000  1.000  
1002207000 10B  Lime, juice                        0.150000   2.000  1.000  
1002207001 10B  Lime, juice-babyfood               0.150000   2.000  1.000  
1003180000 10C  Grapefruit                         0.150000   1.000  1.000  
1003181000 10C  Grapefruit, juice                  0.150000   2.100  1.000  
1003307000 10C  Pummelo                            0.150000   1.000  1.000  
1100007000 11   Apple, fruit with peel             0.250000   1.000  1.000  
1100008000 11   Apple, peeled fruit                0.250000   1.000  1.000  
1100008001 11   Apple, peeled fruit-babyfood       0.250000   1.000  1.000  
1100009000 11   Apple, dried                       0.250000   8.000  1.000  
1100009001 11   Apple, dried-babyfood              0.250000   8.000  1.000  
1100010000 11   Apple, juice                       0.250000   1.300  1.000  
1100010001 11   Apple, juice-babyfood              0.250000   1.300  1.000  
1100011000 11   Apple, sauce                       0.250000   1.000  1.000  
1100011001 11   Apple, sauce-babyfood              0.250000   1.000  1.000  
1100129000 11   Crabapple                          0.250000   1.000  1.000  
1100210000 11   Loquat                             0.250000   1.000  1.000  
1100266000 11   Pear                               0.250000   1.000  1.000  
1100266001 11   Pear-babyfood                      0.250000   1.000  1.000  
1100267000 11   Pear, dried                        0.250000   6.250  1.000  
1100268000 11   Pear, juice                        0.250000   1.000  1.000  
1100268001 11   Pear, juice-babyfood               0.250000   1.000  1.000  
1100310000 11   Quince                             0.250000   1.000  1.000  
1201090000 12A  Cherry                             0.250000   1.000  1.000  
1201090001 12A  Cherry-babyfood                    0.250000   1.000  1.000  
1201091000 12A  Cherry, juice                      0.250000   1.500  1.000  
1201091001 12A  Cherry, juice-babyfood             0.250000   1.500  1.000  
1202012000 12B  Apricot                            0.250000   1.000  1.000  
1202012001 12B  Apricot-babyfood                   0.250000   1.000  1.000  
1202013000 12B  Apricot, dried                     0.250000   6.000  1.000  
1202014000 12B  Apricot, juice                     0.250000   1.000  1.000  
1202014001 12B  Apricot, juice-babyfood            0.250000   1.000  1.000  
1202230000 12B  Nectarine                          0.250000   1.000  1.000  
1202260000 12B  Peach                              0.250000   1.000  1.000  
1202260001 12B  Peach-babyfood                     0.250000   1.000  1.000  
1202261000 12B  Peach, dried                       0.250000   7.000  1.000  
1202261001 12B  Peach, dried-babyfood              0.250000   7.000  1.000  
1202262000 12B  Peach, juice                       0.250000   1.000  1.000  
1202262001 12B  Peach, juice-babyfood              0.250000   1.000  1.000  
1203285000 12C  Plum                               0.250000   1.000  1.000  
1203285001 12C  Plum-babyfood                      0.250000   1.000  1.000  
1203286000 12C  Plum, prune, fresh                 0.250000   1.000  1.000  
1203286001 12C  Plum, prune, fresh-babyfood        0.250000   1.000  1.000  
1203287000 12C  Plum, prune, dried                 0.250000   5.000  1.000  
1203287001 12C  Plum, prune, dried-babyfood        0.250000   5.000  1.000  
1203288000 12C  Plum, prune, juice                 0.250000   1.400  1.000  
1203288001 12C  Plum, prune, juice-babyfood        0.250000   1.400  1.000  
1302057000 13B  Blueberry                          0.150000   1.000  1.000  
1302057001 13B  Blueberry-babyfood                 0.150000   1.000  1.000  
1302136000 13B  Currant                            0.150000   1.000  1.000  
1302137000 13B  Currant, dried                     0.150000   1.000  1.000  
1302149000 13B  Elderberry                         0.150000   1.000  1.000  
1302174000 13B  Gooseberry                         0.150000   1.000  1.000  
1302191000 13B  Huckleberry                        0.150000   1.000  1.000  
1304175000 13D  Grape                              0.050000   1.000  1.000  
1304176000 13D  Grape, juice                       0.050000   1.200  1.000  
1304176001 13D  Grape, juice-babyfood              0.050000   1.200  1.000  
1304179000 13D  Grape, wine and sherry             0.050000   1.000  1.000  
1400003000 14   Almond                             0.100000   1.000  1.000  
1400003001 14   Almond-babyfood                    0.100000   1.000  1.000  
1400004000 14   Almond, oil                        0.100000   1.000  1.000  
1400004001 14   Almond, oil-babyfood               0.100000   1.000  1.000  
1400059000 14   Brazil nut                         0.100000   1.000  1.000  
1400068000 14   Butternut                          0.100000   1.000  1.000  
1400081000 14   Cashew                             0.100000   1.000  1.000  
1400092000 14   Chestnut                           0.100000   1.000  1.000  
1400155000 14   Hazelnut                           0.100000   1.000  1.000  
1400156000 14   Hazelnut, oil                      0.100000   1.000  1.000  
1400185000 14   Hickory nut                        0.100000   1.000  1.000  
1400213000 14   Macadamia nut                      0.100000   1.000  1.000  
1400269000 14   Pecan                              0.100000   1.000  1.000  
1400282000 14   Pistachio                          0.100000   1.000  1.000  
1400391000 14   Walnut                             0.100000   1.000  1.000  
1500120000 15   Corn, field, flour                 0.200000   1.000  1.000  
1500120001 15   Corn, field, flour-babyfood        0.200000   1.000  1.000  
1500121000 15   Corn, field, meal                  0.200000   1.000  1.000  
1500121001 15   Corn, field, meal-babyfood         0.200000   1.000  1.000  
1500122000 15   Corn, field, bran                  0.200000   1.000  1.000  
1500123000 15   Corn, field, starch                0.200000   1.000  1.000  
1500123001 15   Corn, field, starch-babyfood       0.200000   1.000  1.000  
1500124000 15   Corn, field, syrup                 0.200000   1.500  1.000  
1500124001 15   Corn, field, syrup-babyfood        0.200000   1.500  1.000  
1500125000 15   Corn, field, oil                   0.200000   1.000  1.000  
1500125001 15   Corn, field, oil-babyfood          0.200000   1.000  1.000  
1500127000 15   Corn, sweet                        0.250000   1.000  1.000  
1500127001 15   Corn, sweet-babyfood               0.250000   1.000  1.000  
1500323000 15   Rice, white                        1.000000   1.000  1.000  
1500323001 15   Rice, white-babyfood               1.000000   1.000  1.000  
1500324000 15   Rice, brown                        1.000000   1.000  1.000  
1500324001 15   Rice, brown-babyfood               1.000000   1.000  1.000  
1500325000 15   Rice, flour                        1.000000   1.000  1.000  
1500325001 15   Rice, flour-babyfood               1.000000   1.000  1.000  
1500326000 15   Rice, bran                         1.000000   1.000  1.000  
1500326001 15   Rice, bran-babyfood                1.000000   1.000  1.000  
1500381000 15   Triticale, flour                   0.400000   1.000  1.000  
1500381001 15   Triticale, flour-babyfood          0.400000   1.000  1.000  
2001319000 20A  Rapeseed, oil                      0.400000   1.000  1.000  
2001319001 20A  Rapeseed, oil-babyfood             0.400000   1.000  1.000  
2003128000 20C  Cottonseed, oil                    4.000000   1.000  1.000  
2003128001 20C  Cottonseed, oil-babyfood           4.000000   1.000  1.000  
3100044000 31   Beef, meat                         0.150000   1.000  1.000  
3100044001 31   Beef, meat-babyfood                0.150000   1.000  1.000  
3100045000 31   Beef, meat, dried                  0.150000   1.920  1.000  
3100046000 31   Beef, meat byproducts              6.000000   1.000  1.000  
3100046001 31   Beef, meat byproducts-babyfood     6.000000   1.000  1.000  
3100047000 31   Beef, fat                          0.400000   1.000  1.000  
3100047001 31   Beef, fat-babyfood                 0.400000   1.000  1.000  
3100048000 31   Beef, kidney                       6.000000   1.000  1.000  
3100049000 31   Beef, liver                        6.000000   1.000  1.000  
3100049001 31   Beef, liver-babyfood               6.000000   1.000  1.000  
3200169000 32   Goat, meat                         0.150000   1.000  1.000  
3200170000 32   Goat, meat byproducts              6.000000   1.000  1.000  
3200171000 32   Goat, fat                          0.400000   1.000  1.000  
3200172000 32   Goat, kidney                       6.000000   1.000  1.000  
3200173000 32   Goat, liver                        6.000000   1.000  1.000  
3300189000 33   Horse, meat                        0.150000   1.000  1.000  
3400290000 34   Pork, meat                         0.150000   1.000  1.000  
3400290001 34   Pork, meat-babyfood                0.150000   1.000  1.000  
3400291000 34   Pork, skin                         6.000000   1.000  1.000  
3400292000 34   Pork, meat byproducts              6.000000   1.000  1.000  
3400292001 34   Pork, meat byproducts-babyfood     6.000000   1.000  1.000  
3400293000 34   Pork, fat                          0.400000   1.000  1.000  
3400293001 34   Pork, fat-babyfood                 0.400000   1.000  1.000  
3400294000 34   Pork, kidney                       6.000000   1.000  1.000  
3400295000 34   Pork, liver                        6.000000   1.000  1.000  
3500339000 35   Sheep, meat                        0.150000   1.000  1.000  
3500339001 35   Sheep, meat-babyfood               0.150000   1.000  1.000  
3500340000 35   Sheep, meat byproducts             6.000000   1.000  1.000  
3500341000 35   Sheep, fat                         0.400000   1.000  1.000  
3500341001 35   Sheep, fat-babyfood                0.400000   1.000  1.000  
3500342000 35   Sheep, kidney                      6.000000   1.000  1.000  
3500343000 35   Sheep, liver                       6.000000   1.000  1.000  
3600222000 36   Milk, fat                          0.150000   1.000  1.000  
3600222001 36   Milk, fat-baby food/infant formu   0.150000   1.000  1.000  
3600223000 36   Milk, nonfat solids                0.150000   1.000  1.000  
3600223001 36   Milk, nonfat solids-baby food/in   0.150000   1.000  1.000  
3600224000 36   Milk, water                        0.150000   1.000  1.000  
3600224001 36   Milk, water-babyfood/infant form   0.150000   1.000  1.000  
3600225001 36   Milk, sugar (lactose)-baby food/   0.150000   1.000  1.000  
3800221000 38   Meat, game                         0.150000   1.000  1.000  
3900312000 39   Rabbit, meat                       0.150000   1.000  1.000  
4000093000 40   Chicken, meat                      0.150000   1.000  1.000  
4000093001 40   Chicken, meat-babyfood             0.150000   1.000  1.000  
4000094000 40   Chicken, liver                     0.600000   1.000  1.000  
4000095000 40   Chicken, meat byproducts           0.600000   1.000  1.000  
4000095001 40   Chicken, meat byproducts-babyfoo   0.600000   1.000  1.000  
4000096000 40   Chicken, fat                       0.150000   1.000  1.000  
4000096001 40   Chicken, fat-babyfood              0.150000   1.000  1.000  
4000097000 40   Chicken, skin                      0.600000   1.000  1.000  
4000097001 40   Chicken, skin-babyfood             0.600000   1.000  1.000  
5000382000 50   Turkey, meat                       0.150000   1.000  1.000  
5000382001 50   Turkey, meat-babyfood              0.150000   1.000  1.000  
5000383000 50   Turkey, liver                      0.600000   1.000  1.000  
5000383001 50   Turkey, liver-babyfood             0.600000   1.000  1.000  
5000384000 50   Turkey, meat byproducts            0.600000   1.000  1.000  
5000384001 50   Turkey, meat byproducts-babyfood   0.600000   1.000  1.000  
5000385000 50   Turkey, fat                        0.150000   1.000  1.000  
5000385001 50   Turkey, fat-babyfood               0.150000   1.000  1.000  
5000386000 50   Turkey, skin                       0.600000   1.000  1.000  
5000386001 50   Turkey, skin-babyfood              0.600000   1.000  1.000  
6000301000 60   Poultry, other, meat               0.150000   1.000  1.000  
6000302000 60   Poultry, other, liver              0.600000   1.000  1.000  
6000303000 60   Poultry, other, meat byproducts    0.600000   1.000  1.000  
6000304000 60   Poultry, other, fat                0.150000   1.000  1.000  
6000305000 60   Poultry, other, skin               0.600000   1.000  1.000  
7000145000 70   Egg, whole                         0.150000   1.000  1.000  
7000145001 70   Egg, whole-babyfood                0.150000   1.000  1.000  
7000146000 70   Egg, white                         0.150000   1.000  1.000  
7000146001 70   Egg, white (solids)-babyfood       0.150000   1.000  1.000  
7000147000 70   Egg, yolk                          0.150000   1.000  1.000  
7000147001 70   Egg, yolk-babyfood                 0.150000   1.000  1.000  
8601000000 86A  Water, direct, all sources         0.390000   1.000  1.000  
8602000000 86B  Water, indirect, all sources       0.390000   1.000  1.000  
9500023000 O    Banana                             0.300000   1.000  1.000  
9500023001 O    Banana-babyfood                    0.300000   1.000  1.000  
9500024000 O    Banana, dried                      0.300000   3.900  1.000  
9500024001 O    Banana, dried-babyfood             0.300000   3.900  1.000  
9500177000 O    Grape, leaves                      0.050000   1.000  1.000  
9500178000 O    Grape, raisin                      0.050000   4.300  1.000  
9500235000 O    Olive                              0.150000   1.000  1.000  
9500236000 O    Olive, oil                         0.150000   1.000  1.000  
9500283000 O    Plantain                           0.300000   1.000  1.000  
9500284000 O    Plantain, dried                    0.300000   3.900  1.000  

Attachment 2:  Acute Results File at an EDWC of 390 ppb.

                                                                      Ver. 3.10
DEEM-FCID ACUTE Analysis for GLUFOSINATE AMMONIUM                NHANES 2003-2008
Residue file: 128850a.R08                         Adjustment factor #2 NOT used.
Analysis Date: 06-19-2012/09:29:22    Residue file dated: 06-19-2012/08:02:29
Two-Day Average Results Reported
RAC/FF intake summed over 24 hours
Run Comment: "acute EDWC 390 ppb 30may12"
===============================================================================

Summary calculations--per capita:

                   95th Percentile      99th Percentile     99.9th Percentile
                   Exposure   % aRfD    Exposure   % aRfD    Exposure   % aRfD 
                  ---------- --------  ---------- --------  ---------- --------
Female 13-49:
                    0.024401    38.73    0.033361    52.95    0.043600    69.21 

Attachment 3:  Chronic Food plus Water Residue Input File at an EDWC of 95 ppb

Filename: C:\Documents and Settings\wdonovan\My Documents\CalendexWWEIAFCID\128850c.R08
Chemical: glufosinate ammonium
RfD(Chronic): .006 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day
RfD(Acute): .063 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day
Date created/last modified: 05-29-2012/12:14:56            Program ver. 3.10
Comment: 95 ppb EDWC, 2012 SLUA
--------------------------------------------------------------------------------
   EPA     Crop                                   Def Res     Adj.Factors   Comment
   Code     Grp  Commodity Name                    (ppm)       #1    #2   
---------- ---- -------------------------------  ----------  ------ ------  -------
0101052000 1A   Beet, sugar                        0.240000   0.100  1.000  avg re
            Full comment: avg res from fld trl and proc fact (D257628)
0101052001 1A   Beet, sugar-babyfood               0.240000   0.100  1.000  avg re
            Full comment: avg res from fld trl and proc fact (D257628)
0101053000 1A   Beet, sugar, molasses              0.240000   6.800  1.000  avg re
            Full comment: avg res from fld trl and proc fact (D257628)
0101053001 1A   Beet, sugar, molasses-babyfood     0.240000   6.800  1.000  avg re
            Full comment: avg res from fld trl and proc fact (D257628)
0103296000 1C   Potato, chips                      0.190000   2.300  0.100  avg re
            Full comment: avg res from fld trl and proc factor (D257628)
0103297000 1C   Potato, dry (granules/ flakes)     0.190000   3.000  0.100  avg re
            Full comment: avg res from fld trl and proc factor (D257628)
0103297001 1C   Potato, dry (granules/ flakes)-b   0.190000   3.000  0.100  avg re
            Full comment: avg res from fld trl and proc factor (D257628)
0103298000 1C   Potato, flour                      0.190000   3.000  0.100  avg re
            Full comment: avg res from fld trl and proc factor (D257628)
0103298001 1C   Potato, flour-babyfood             0.190000   3.000  0.100  avg re
            Full comment: avg res from fld trl and proc factor (D257628)
0103299000 1C   Potato, tuber, w/peel              0.190000   1.000  0.100  avg re
            Full comment: avg res from fld trl
0103299001 1C   Potato, tuber, w/peel-babyfood     0.190000   1.000  0.100  avg re
            Full comment: avg res from fld trl
0103300000 1C   Potato, tuber, w/o peel            0.190000   1.000  0.100  avg re
            Full comment: avg res from fld trl
0103300001 1C   Potato, tuber, w/o peel-babyfood   0.190000   1.000  0.100  avg re
            Full comment: avg res from fld trl
0600347000 6    Soybean, seed                      0.770000   1.000  0.010  avg fi
            Full comment: avg field trial residue (D211531)
0600349000 6    Soybean, soy milk                  0.770000   1.000  0.010  avg fi
            Full comment: avg field trial residue (D211531)
0600349001 6    Soybean, soy milk-babyfood or in   0.770000   1.000  0.010  avg fi
            Full comment: avg field trial residue (D211531)
0600350000 6    Soybean, oil                       0.770000   0.750  0.010  avg fl
            Full comment: avg fld trl res and 0.75x proc factor (D211531)
0600350001 6    Soybean, oil-babyfood              0.770000   0.750  0.010  avg fl
            Full comment: avg fld trl res and 0.75x proc factor (D211531)
0603348000 6C   Soybean, flour                     0.770000   1.000  0.010  avg fi
            Full comment: avg field trial residue (D211531)
0603348001 6C   Soybean, flour-babyfood            0.770000   1.000  0.010  avg fi
            Full comment: avg field trial residue (D211531)
1001106000 10A  Citron                             0.075000   1.000  1.000  
1001107000 10A  Citrus hybrids                     0.075000   1.000  1.000  
1001108000 10A  Citrus, oil                        0.075000   1.000  1.000  
1001240000 10A  Orange                             0.075000   1.000  1.000  
1001241000 10A  Orange, juice                      0.075000   1.000  1.000  
1001241001 10A  Orange, juice-babyfood             0.075000   1.000  1.000  
1001242000 10A  Orange, peel                       0.075000   1.000  1.000  
1001369000 10A  Tangerine                          0.075000   1.000  1.000  
1001370000 10A  Tangerine, juice                   0.075000   1.000  1.000  
1002197000 10B  Kumquat                            0.075000   1.000  1.000  
1002199000 10B  Lemon                              0.075000   1.000  1.000  
1002200000 10B  Lemon, juice                       0.075000   1.000  1.000  
1002200001 10B  Lemon, juice-babyfood              0.075000   1.000  1.000  
1002201000 10B  Lemon, peel                        0.075000   1.000  1.000  
1002206000 10B  Lime                               0.075000   1.000  1.000  
1002207000 10B  Lime, juice                        0.075000   1.000  1.000  
1002207001 10B  Lime, juice-babyfood               0.075000   1.000  1.000  
1003180000 10C  Grapefruit                         0.075000   1.000  1.000  
1003181000 10C  Grapefruit, juice                  0.075000   1.000  1.000  
1003307000 10C  Pummelo                            0.075000   1.000  1.000  
1100007000 11   Apple, fruit with peel             0.025000   1.000  1.000  
1100008000 11   Apple, peeled fruit                0.025000   1.000  1.000  
1100008001 11   Apple, peeled fruit-babyfood       0.025000   1.000  1.000  
1100009000 11   Apple, dried                       0.025000   8.000  1.000  
1100009001 11   Apple, dried-babyfood              0.025000   8.000  1.000  
1100010000 11   Apple, juice                       0.025000   1.000  1.000  proces
            Full comment: processing factor reduced to 1 (PP#8F3607)
1100010001 11   Apple, juice-babyfood              0.025000   1.000  1.000  proces
            Full comment: processing factor reduced to 1 (PP#8F3607)
1100011000 11   Apple, sauce                       0.025000   1.000  1.000  
1100011001 11   Apple, sauce-babyfood              0.025000   1.000  1.000  
1100129000 11   Crabapple                          0.025000   1.000  1.000  from a
            Full comment: from apple SOP 2000.1
1100210000 11   Loquat                             0.155000   1.000  1.000  
1100266000 11   Pear                               0.155000   1.000  1.000  D37262
            Full comment: D372625
1100266001 11   Pear-babyfood                      0.155000   1.000  1.000  D37262
            Full comment: D372625
1100267000 11   Pear, dried                        0.155000   6.250  1.000  D37262
            Full comment: D372625
1100268000 11   Pear, juice                        0.155000   1.000  1.000  D37262
            Full comment: D372625
1100268001 11   Pear, juice-babyfood               0.155000   1.000  1.000  D37262
            Full comment: D372625
1100310000 11   Quince                             0.155000   1.000  1.000  
1201090000 12A  Cherry                             0.156000   1.000  1.000  D37262
            Full comment: D372625
1201090001 12A  Cherry-babyfood                    0.156000   1.000  1.000  D37262
            Full comment: D372625
1201091000 12A  Cherry, juice                      0.156000   1.500  1.000  D37262
            Full comment: D372625
1201091001 12A  Cherry, juice-babyfood             0.156000   1.500  1.000  D37262
            Full comment: D372625
1202012000 12B  Apricot                            0.156000   1.000  1.000  
1202012001 12B  Apricot-babyfood                   0.156000   1.000  1.000  
1202013000 12B  Apricot, dried                     0.156000   6.000  1.000  
1202014000 12B  Apricot, juice                     0.156000   1.000  1.000  
1202014001 12B  Apricot, juice-babyfood            0.156000   1.000  1.000  
1202230000 12B  Nectarine                          0.075000   1.000  1.000  
1202260000 12B  Peach                              0.075000   1.000  1.000  
1202260001 12B  Peach-babyfood                     0.075000   1.000  1.000  
1202261000 12B  Peach, dried                       0.075000   7.000  1.000  
1202261001 12B  Peach, dried-babyfood              0.075000   7.000  1.000  
1202262000 12B  Peach, juice                       0.075000   1.000  1.000  
1202262001 12B  Peach, juice-babyfood              0.075000   1.000  1.000  
1203285000 12C  Plum                               0.153000   1.000  1.000  D37262
            Full comment: D372625
1203285001 12C  Plum-babyfood                      0.153000   1.000  1.000  D37262
            Full comment: D372625
1203286000 12C  Plum, prune, fresh                 0.153000   1.000  1.000  D37262
            Full comment: D372625
1203286001 12C  Plum, prune, fresh-babyfood        0.153000   1.000  1.000  D37262
            Full comment: D372625
1203287000 12C  Plum, prune, dried                 0.153000   1.800  1.000  D37262
            Full comment: D372625
1203287001 12C  Plum, prune, dried-babyfood        0.153000   1.800  1.000  D37262
            Full comment: D372625
1203288000 12C  Plum, prune, juice                 0.153000   1.400  1.000  D37262
            Full comment: D372625
1203288001 12C  Plum, prune, juice-babyfood        0.153000   1.400  1.000  D37262
            Full comment: D372625
1302057000 13B  Blueberry                          0.055000   1.000  0.050  
1302057001 13B  Blueberry-babyfood                 0.055000   1.000  0.050  
1302136000 13B  Currant                            0.055000   1.000  1.000  
1302137000 13B  Currant, dried                     0.055000   1.000  1.000  
1302149000 13B  Elderberry                         0.055000   1.000  1.000  
1302174000 13B  Gooseberry                         0.055000   1.000  1.000  
1302191000 13B  Huckleberry                        0.055000   1.000  1.000  
1304175000 13D  Grape                              0.025000   1.000  0.150  
1304176000 13D  Grape, juice                       0.025000   1.000  0.150  proces
            Full comment: processing factor reduced to 1 (PP#843607)
1304176001 13D  Grape, juice-babyfood              0.025000   1.000  0.150  proces
            Full comment: processing factor reduced to 1 (PP#843607)
1304179000 13D  Grape, wine and sherry             0.025000   1.000  0.150  
1400003000 14   Almond                             0.050000   1.000  0.150  
1400003001 14   Almond-babyfood                    0.050000   1.000  0.150  
1400004000 14   Almond, oil                        0.050000   1.000  0.150  
1400004001 14   Almond, oil-babyfood               0.050000   1.000  0.150  
1400059000 14   Brazil nut                         0.050000   1.000  1.000  
1400068000 14   Butternut                          0.050000   1.000  1.000  
1400081000 14   Cashew                             0.050000   1.000  1.000  
1400092000 14   Chestnut                           0.050000   1.000  1.000  
1400155000 14   Hazelnut                           0.050000   1.000  0.100  
1400156000 14   Hazelnut, oil                      0.050000   1.000  0.100  
1400185000 14   Hickory nut                        0.050000   1.000  1.000  
1400213000 14   Macadamia nut                      0.050000   1.000  1.000  
1400269000 14   Pecan                              0.050000   1.000  0.010  
1400282000 14   Pistachio                          0.050000   1.000  0.200  
1400391000 14   Walnut                             0.050000   1.000  0.100  
1500120000 15   Corn, field, flour                 0.050000   1.000  0.050  avg re
            Full comment: avg res 47542612
1500120001 15   Corn, field, flour-babyfood        0.050000   1.000  0.050  avg re
            Full comment: avg res 47542612
1500121000 15   Corn, field, meal                  0.050000   1.000  0.050  avg re
            Full comment: avg res 47542612
1500121001 15   Corn, field, meal-babyfood         0.050000   1.000  0.050  avg re
            Full comment: avg res 47542612
1500122000 15   Corn, field, bran                  0.050000   1.000  0.050  avg re
            Full comment: avg res 47542612
1500123000 15   Corn, field, starch                0.050000   1.000  0.050  avg re
            Full comment: avg res 47542612
1500123001 15   Corn, field, starch-babyfood       0.050000   1.000  0.050  avg re
            Full comment: avg res 47542612
1500124000 15   Corn, field, syrup                 0.050000   1.500  0.050  avg re
            Full comment: avg res 47542612
1500124001 15   Corn, field, syrup-babyfood        0.050000   1.500  0.050  avg re
            Full comment: avg res 47542612
1500125000 15   Corn, field, oil                   0.050000   1.000  0.050  avg re
            Full comment: avg res 47542612
1500125001 15   Corn, field, oil-babyfood          0.050000   1.000  0.050  avg re
            Full comment: avg res 47542612
1500127000 15   Corn, sweet                        0.110000   1.000  1.000  mean r
            Full comment: mean res D372625
1500127001 15   Corn, sweet-babyfood               0.110000   1.000  1.000  mean r
            Full comment: mean res D372625
1500323000 15   Rice, white                        0.200000   1.300  0.010  avg re
            Full comment: avg res from fld trl and proc fact (D27110)
1500323001 15   Rice, white-babyfood               0.200000   1.300  0.010  avg re
            Full comment: avg res from fld trl and proc fact (D27110)
1500324000 15   Rice, brown                        0.200000   1.300  0.010  avg re
            Full comment: avg res from fld trl and proc fact (D27110)
1500324001 15   Rice, brown-babyfood               0.200000   1.300  0.010  avg re
            Full comment: avg res from fld trl and proc fact (D27110)
1500325000 15   Rice, flour                        0.200000   1.300  0.010  avg re
            Full comment: avg res from fld trl and proc fact (D27110)
1500325001 15   Rice, flour-babyfood               0.200000   1.300  0.010  avg re
            Full comment: avg res from fld trl and proc fact (D27110)
1500326000 15   Rice, bran                         0.200000   0.900  0.010  avg re
            Full comment: avg res from fld trl and proc fact (D27110)
1500326001 15   Rice, bran-babyfood                0.200000   0.900  0.010  avg re
            Full comment: avg res from fld trl and proc fact (D27110)
1500381000 15   Triticale, flour                   0.200000   1.000  1.000  
1500381001 15   Triticale, flour-babyfood          0.200000   1.000  1.000  
2001319000 20A  Rapeseed, oil                      0.200000   1.000  0.250  
2001319001 20A  Rapeseed, oil-babyfood             0.200000   1.000  0.250  
2003128000 20C  Cottonseed, oil                    1.120000   0.010  0.050  avg re
            Full comment: avg res from fld trl & proc fact (D271110)
2003128001 20C  Cottonseed, oil-babyfood           1.120000   0.010  0.050  avg re
            Full comment: avg res from fld trl & proc fact (D271110)
3100044000 31   Beef, meat                         0.005900   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3100044001 31   Beef, meat-babyfood                0.005900   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3100045000 31   Beef, meat, dried                  0.005900   1.920  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3100046000 31   Beef, meat byproducts              0.960000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3100046001 31   Beef, meat byproducts-babyfood     0.960000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3100047000 31   Beef, fat                          0.065000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3100047001 31   Beef, fat-babyfood                 0.065000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3100048000 31   Beef, kidney                       0.300000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3100049000 31   Beef, liver                        0.960000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3100049001 31   Beef, liver-babyfood               0.960000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3200169000 32   Goat, meat                         0.005900   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3200170000 32   Goat, meat byproducts              0.960000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3200171000 32   Goat, fat                          0.065000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3200172000 32   Goat, kidney                       0.300000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3200173000 32   Goat, liver                        0.960000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3300189000 33   Horse, meat                        0.005900   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3400290000 34   Pork, meat                         0.000590   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3400290001 34   Pork, meat-babyfood                0.000590   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3400291000 34   Pork, skin                         0.096000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3400292000 34   Pork, meat byproducts              0.096000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3400292001 34   Pork, meat byproducts-babyfood     0.096000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3400293000 34   Pork, fat                          0.006500   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3400293001 34   Pork, fat-babyfood                 0.006500   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3400294000 34   Pork, kidney                       0.030000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3400295000 34   Pork, liver                        0.096000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3500339000 35   Sheep, meat                        0.005900   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3500339001 35   Sheep, meat-babyfood               0.005900   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3500340000 35   Sheep, meat byproducts             0.960000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3500341000 35   Sheep, fat                         0.065000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3500341001 35   Sheep, fat-babyfood                0.065000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3500342000 35   Sheep, kidney                      0.300000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3500343000 35   Sheep, liver                       0.960000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3600222000 36   Milk, fat                          0.006800   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3600222001 36   Milk, fat-baby food/infant formu   0.006800   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3600223000 36   Milk, nonfat solids                0.006800   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3600223001 36   Milk, nonfat solids-baby food/in   0.006800   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3600224000 36   Milk, water                        0.006800   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3600224001 36   Milk, water-babyfood/infant form   0.006800   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3600225001 36   Milk, sugar (lactose)-baby food/   0.006800   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3800221000 38   Meat, game                         0.005900   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
3900312000 39   Rabbit, meat                       0.005900   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
4000093000 40   Chicken, meat                      0.007100   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
4000093001 40   Chicken, meat-babyfood             0.007100   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
4000094000 40   Chicken, liver                     0.014000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
4000095000 40   Chicken, meat byproducts           0.046000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
4000095001 40   Chicken, meat byproducts-babyfoo   0.046000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
4000096000 40   Chicken, fat                       0.007100   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
4000096001 40   Chicken, fat-babyfood              0.007100   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
4000097000 40   Chicken, skin                      0.007100   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
4000097001 40   Chicken, skin-babyfood             0.007100   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
5000382000 50   Turkey, meat                       0.007100   1.000  1.000  AR RDB
            Full comment: AR RDB June 2008
5000382001 50   Turkey, meat-babyfood              0.007100   1.000  1.000  AR RDB
            Full comment: AR RDB June 2008
5000383000 50   Turkey, liver                      0.014000   1.000  1.000  AR RDB
            Full comment: AR RDB June 2008
5000383001 50   Turkey, liver-babyfood             0.014000   1.000  1.000  AR RDB
            Full comment: AR RDB June 2008
5000384000 50   Turkey, meat byproducts            0.046000   1.000  1.000  AR RDB
            Full comment: AR RDB June 2008
5000384001 50   Turkey, meat byproducts-babyfood   0.046000   1.000  1.000  AR RDB
            Full comment: AR RDB June 2008
5000385000 50   Turkey, fat                        0.007100   1.000  1.000  AR RDB
            Full comment: AR RDB June 2008
5000385001 50   Turkey, fat-babyfood               0.007100   1.000  1.000  AR RDB
            Full comment: AR RDB June 2008
5000386000 50   Turkey, skin                       0.007100   1.000  1.000  AR RDB
            Full comment: AR RDB June 2008
5000386001 50   Turkey, skin-babyfood              0.007100   1.000  1.000  AR RDB
            Full comment: AR RDB June 2008
6000301000 60   Poultry, other, meat               0.007100   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
6000302000 60   Poultry, other, liver              0.014000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
6000303000 60   Poultry, other, meat byproducts    0.046000   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
6000304000 60   Poultry, other, fat                0.007100   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
6000305000 60   Poultry, other, skin               0.007100   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
7000145000 70   Egg, whole                         0.007100   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
7000145001 70   Egg, whole-babyfood                0.007100   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
7000146000 70   Egg, white                         0.007100   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
7000146001 70   Egg, white (solids)-babyfood       0.007100   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
7000147000 70   Egg, yolk                          0.007100   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
7000147001 70   Egg, yolk-babyfood                 0.007100   1.000  1.000  AR RBD
            Full comment: AR RBD Jun 2008
8601000000 86A  Water, direct, all sources         0.095000   1.000  1.000  EFED E
            Full comment: EFED EDWC 
8602000000 86B  Water, indirect, all sources       0.095000   1.000  1.000  EFED E
            Full comment: EFED EDWC 
9500023000 O    Banana                             0.080000   1.000  1.000  avg fi
            Full comment: avg field trial residue (D172878)
9500023001 O    Banana-babyfood                    0.080000   1.000  1.000  avg fi
            Full comment: avg field trial residue (D172878)
9500024000 O    Banana, dried                      0.080000   3.900  1.000  avg fi
            Full comment: avg field trial residue (D172878)
9500024001 O    Banana, dried-babyfood             0.080000   3.900  1.000  avg fi
            Full comment: avg field trial residue (D172878)
9500177000 O    Grape, leaves                      0.025000   1.000  0.150  
9500178000 O    Grape, raisin                      0.025000   1.000  0.150  proces
            Full comment: processing factor reduced to 1 (PP#8F3607)
9500235000 O    Olive                              0.075000   1.000  1.000  
9500236000 O    Olive, oil                         0.075000   0.600  1.000  
9500283000 O    Plantain                           0.080000   1.000  1.000  
9500284000 O    Plantain, dried                    0.080000   3.900  1.000  
Attachment 4:  Chronic Results File at an EDWC of 95 ppb.

                                                                      Ver. 3.10
DEEM-FCID Chronic analysis for GLUFOSINATE AMMONIUM        NHANES 2003-2008 2-day
Residue file name: C:\Documents and Settings\wdonovan\My Documents\CalendexWWEIAFCID\128850c.R08
                                                     Adjustment factor #2 used.
Analysis Date 06-19-2012/09:32:00     Residue file dated: 06-19-2012/08:05:17
Reference dose (RfD, Chronic) = .006 mg/kg bw/day
COMMENT 1: 95 ppb EDWC, 2012 SLUA
===============================================================================
                    Total exposure by population subgroup
-------------------------------------------------------------------------------

                                                    Total Exposure
                                         -----------------------------------
          Population                         mg/kg             Percent of   
           Subgroup                       body wt/day             Rfd       
--------------------------------------   -------------       ----------------
Total US Population                         0.002324                38.7%
Hispanic                                    0.002343                39.0%
Non-Hisp-White                              0.002353                39.2%
Non-Hisp-Black                              0.001998                33.3%
Non-Hisp-Other                              0.002668                44.5%
Nursing Infants                             0.002273                37.9%
Non-Nursing Infants                         0.007501               125.0%
Female 13+ PREG                             0.002198                36.6%
Children 1-6                                0.003708                61.8%
Children 7-12                               0.002130                35.5%
Male 13-19                                  0.001645                27.4%
Female 13-19/NP                             0.001767                29.4%
Male 20+                                    0.002084                34.7%
Female 20+/NP                               0.002310                38.5%
Seniors 55+                                 0.002166                36.1%
All Infants                                 0.005887                98.1%
Female 13-50                                0.002198                36.6%
Children 1-2                                0.004387                73.1%
Children 3-5                                0.003447                57.4%
Children 6-12                               0.002261                37.7%
Youth 13-19                                 0.001706                28.4%
Adults 20-49                                0.002203                36.7%
Adults 50-99                                0.002202                36.7%
Female 13-49                                0.002195                36.6%

-------------------------------------------------------------------------------

Attachment 5.  Dietary Burden and Livestock AR Calculations for Glufosinate Ammonium.

Table 6: Livestock Anticipated Dietary Burden Calculation for Glufosinate Ammonium (Chronic Scenario)  

                                   commodity

                                Average residue
                                     (ppm)

                                 % dry matter

                                    % diet

                             dietary burden (ppm)

                                  Beef cattle

                                 Dairy cattle
                                    Poultry
                                     Swine

                                  Beef cattle

                                 Dairy cattle
                                    Poultry
                                     Swine

aspirated grain fractions   CC

                                    9.2[a]

                                      85

                                       5
                                      --

                                      --

                                      --

                                     0.54

                                      --

                                      --
                                      --

field corn grain   CC

                                    0.05[b]

                                      88

                                      45

                                      15
                                      55
                                      65

                                     0.026

                                    0.0085
                                     0.028
                                     0.033

field corn forage   R

                                    1.8[c]

                                      40

                                      10

                                      45
                                      --
                                      --

                                     0.45

                                     2.03
                                      --
                                      --

soybean hulls    R

                                    2.0[c]

                                      90

                                      --

                                      --
                                      --
                                      --

                                      --

                                      --
                                      --
                                      --

soybean meal   PC

                                    0.77[c]

                                      92

                                      --

                                      --
                                       5
                                      --

                                      --

                                      --
                                     0.039
                                      --

soybean seed   PC

                                    0.77[b]

                                      89

                                       5

                                      --
                                      20
                                      15

                                     0.043

                                      --
                                     0.154
                                     0.12

sugar beet molasses   CC

                                    1.6[d]

                                      75

                                      10

                                      10
                                      --
                                      --

                                     0.21

                                     0.21
                                      --
                                      --

undelinted cottonseed   PC

                                    1.1[e]

                                      88

                                      --

                                      10
                                      --
                                      --

                                      --

                                     0.125
                                      --
                                      --

cotton gin byproducts   R

                                    3.8[e]

                                      90

                                       5

                                      --
                                      --
                                      --

                                     0.21

                                      --
                                      --
                                      --

rice grain   CC

                                    0.2[e]

                                      88

                                      20

                                      20
                                      20
                                      20

                                     0.045

                                     0.045
                                     0.04
                                     0.04

dietary burden

                                     1.52
                                     2.42
                                     0.26
                                     0.19

a  D227386, M.I. Rodriguez, 26-AUG-1996.  Max CF = 12x.  AR = CF X Avg soybean residue = 12 X 0.77 = 9.24 ppm.
b   D211531, M.I. Rodriguez, 07-MAR-1996.
c  D219069 & D211531, M.I. Rodriguez, 07-MAR-1996.  Range of F. corn forage residues: 0.15  -  3.6 ppm.  Avg = (1/2) X 3.6 = 1.8. ppm.  Soybean hulls:  2.66 (CF) X 0.77 = 2.0 ppm; soybean meal:  1.0 (CF) X 0.77 = 0.77 ppm.
d  D257682, T. Bloem, 09-JUL-1999.  Molasses CF = 6.8X.  6.8 x 0.24 ppm (Avg sugar beet residue) = 1.6 ppm.
[e]  D271110, T. Bloem, 20-JUN-2002 [45089303.der.wpd]  cottonseed avg = 1.12 ppm; cotton gin byproduct avg = 3.76 ppm.  [45204406.der.wpd] rice grain avg = 0.20 ppm.

Table 7: Results of a Ruminant Feeding Study; Livestock Fed a Diet Spiked with Glufosinate Ammonium:HOE 061517 (15:85)

MRID 43766921 (D211531, M. Rodriguez, 7-Mar-1996)

                                       
                                   commodity

                 maximum combined 039866, 099730, and 061517 
                   residue at the three dosing levels (ppm)

combined 039866, 099730, and 061517 residue used in the chronic dietary exposure assessment
                                       
                                       

                                   9.1 ppm 
                                 beef  -  5.9x
                                dairy  -  3.8x

                                   27.3 ppm 
                                  beef --18x
                                 dairy  -  11x

                                   91.1 ppm 
                                 beef  -  59x
                                 dairy  -  38x
                                       

milk

                                   <0.04

                                   <0.048

                                     0.259

Residue = 0.259/38 = 0.0068 ppm cow

kidney

                                   <0.20

                                   <0.20

                                     0.28

residues in this study were generally <LOQ while residues in the 3:1 glufosinate ammonium:061517 feeding study (see below) were generally >LOQ; therefore, the 3:1 feeding study was used for calculation of residues in kidney, liver, meat, and fat (see below) 

fat

                                   <0.10

                                   <0.10

                                   <0.10

liver

                                   <0.20

                                   <0.20

                                     0.39

muscle

                                   <0.10

                                   <0.10

                                   <0.10

Table 8:  Results of a Ruminant Feeding Study; Livestock Fed a Diet Spiked with Glufosinate Ammonium:HOE 061517 (3:1)

PP#8F3607, J. Garbus, 8-Aug-1990

                                       
                                   commodity

                 maximum combined 039866, 099730, and 061517 
                   residue at the three dosing levels (ppm)

combined 039866, 099730, and 061517 residue used in the chronic dietary exposure assessment

                                    4 ppm 
                                 beef  -  2.6x
                                dairy  -  1.7x

                                    12 ppm 
                                  beef -7.8x
                                dairy  -  5.0x

                                    40 ppm 
                                 beef  -  26x
                                 dairy  -  17x
                                       

milk

                                   <0.07

                                   <0.07

                                   <0.07

residues in this study were <LOQ while residues in the 15:85 glufosinate ammonium:061517 feeding study (see above) were >LOQ; therefore, the 15:85 feeding study was used for calculation of residues in milk (see above) 

kidney

                                   <0.51

                                    <2.1

                                      7.5
Residue = 0.51/1.7 = 0.30 ppm cow; 0.03 ppm swine

muscle

                                   <0.10

                                   <0.10

                                   <0.10

Residue = 0.10/17 = 0.0059 ppm cow; 0.00059 ppm swine

fat

                                   <0.11

                                   <0.13

                                   <0.21

Residue = 0.11/1.7 = 0.065 ppm cow; 0.0065 ppm swine

liver

                                     1.63

                                    <4.3

                                   <10.8

Residue = 1.63/1.7 = 0.96 ppm cow; 0.096 ppm swine
[1]  Residue in cattle  10x to calculate residue in swine (swine diet approx. 10x less than that of cattle)

		Table 9.  Results of Glufosinate Ammonium Feeding Studies in Hens.

                                    matrix

ppm (glufosinate free acid equivalents)  in Laying Hens dosed with 15:85 glufosinate ammonium:N-acetyl-glufosinate

                                  HOE 039866/
                                 HOE 099730[2]
                                       +
                                  HOE 061517

                                  HOE 039866/
                                 HOE 099730[2]
                                       +
                                  HOE 061517

                                  HOE 039866/
                                 HOE 099730[2]
                                       +
                                  HOE 061517

Chronic anticipated residue at 1x RDB[1]
                                       

                             0.36 ppm [1.4x MTDB]

                             1.08 ppm [4.2x MTDB]

                              3.6 ppm [14x MTDB]
                                       

liver

                                   <0.20

                                   <0.20

                                   <0.20
                                   <0.014

skin

                                   <0.10

                                   <0.10

                                   <0.10
                                  <0.0071

muscle

                                   <0.10

                                   <0.10

                                   <0.10
                                  <0.0071

fat

                                   <0.10

                                   <0.10

                                   <0.10
                                  <0.0071

egg

                                   <0.10

                                   <0.10

                                   <0.10
                                  <0.0071

                      3:1 glufosinate ammonium:HOE 061517

                              4.5 ppm [17x MTDB]

                              13.5 ppm [52x MTDB]

                              45 ppm [170x MTDB]
                                       

liver

                                   <0.20

                                   <0.20

                                   <0.20
                                   See above

kidney

                                   <0.74

                                     2.07

                                     7.85
                                     0.046

muscle

                                   <0.10

                                   <0.10

                                   <0.10
                                   See above

fat

                                   <0.10

                                   <0.10

                                   <0.10
                                   See above

egg

                                   <0.10

                                   <0.10

                                   <0.12
                                   See above

   [1]	If residues were <LOQ at all three dosing levels then an anticipated residue (AR) was calculated using the results from the highest dose level.  If residues were >LOQ at all three dosing levels, then the AR was calculated using the results from the dosing level closest to the RDB.
   [2]	HOE 099730 was not reported in the 3:1 glufosinate ammonium:HOE 061517 feeding study, analytical method would not have distinguished between HOE 039866 and HOE 099730 or the D and L enantiomers of these compounds

Attachment 6.  Glufosinate Ammonium SLUA dated 19-MAR-2012
   
                               	March 19, 2012 
    Screening Level Estimates of Agricultural Uses of Glufosinate (128850)
                             Sorted Alphabetically
                                                                               

                                                                               
                               Percent Crop Ttd.
                                                                               
Crop
Lbs. A.I.
Avg. PCT
Max. PCT
                                                                              1
Almonds
     200,000
  15
  40
                                                                              2
Apples
       4,000
  <1
<2.5
                                                                              3
Blueberries
      10,000
   5
  15
                                                                              4
Canola
     100,000
  25
  35
                                                                              5
Cherries+
       1,000
  <1
<2.5
                                                                              6
Corn
   1,300,000
   5
  10
                                                                              7
Cotton
     200,000
   5
  10
                                                                              8
Fallow
        <500
  <1
<2.5
                                                                              9
Figs **
        <500
NC
NC
                                                                             10
Grapes
     200,000
  15
  30
                                                                             11
Hazelnuts
       6,000
  10
  25
                                                                             12
Peaches+
       2,000
<2.5
  10
                                                                             13
Peanuts+
       1,000
  <1
<2.5
                                                                             14
Pecans
       1,000
  <1
<2.5
                                                                             15
Pistachios
      50,000
  20
  45
                                                                             16
Plums/Prunes+
       2,000
<2.5
  10
                                                                             17
Pomegranates **
        <500
  NC
NC
                                                                             18
Potatoes
      30,000
  10
  20
                                                                             19
Rice
       5,000
  <1
<2.5
                                                                             20
Soybeans
     100,000
  <1
<2.5
                                                                             21
Sweet Corn
        <500
  <1
<2.5
                                                                             22
Walnuts
      30,000
  10
  20

All numbers rounded.

<500: indicates less than 500 pounds of active ingredient.

<2.5: indicates less than 2.5 percent of crop is treated.

<1: indicates less than 1 percent of crop is treated.

**: California data only.  No information available about use of this chemical on this crop in other states.  
  NC: Not calculated 

                                                                              +
Crops not known to be listed on active end use product registrations or as Section 18 emergency
exemptions when this report was run

SLUA data sources include: 
  USDA-NASS (United States Department of Agriculture's National Agricultural Statistics Service) 
Private Pesticide Market Research
  California DPR (Department of Pesticide Regulation)
These results reflect amalgamated data developed by the Agency and are releasable to the public.