Document ID: EPA-HQ-OPP-2007-0872-0005
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2008-04-23T04:00Z

SEQ CHAPTER \h \r 1 

     

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

                                                                        
                                                                        
                                            

                                                                        
                                                                        
        			      OFFICE OF     

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM

DATE:  	March 5, 2008 

SUBJECT:	Cyazofamid: Acute and Chronic Aggregate Dietary (Food and
Drinking Water) Exposure and Risk Assessments for a PMRA and IR-4
Proposed Section 3 Registration in/on Carrot Root. 

PC Code:	085651			Decision Number: 381623

DP Number: 	343442

REVIEWER:	Amelia M. Acierto, Chemist

Registration Branch 3

Health Effects Division (7509P)

THROUGH:	Anant Parmar, Biologist

Sheila Piper, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P)

and

Paula Deschamp, Branch Chief

Registration Branch 3

Health Effects Division (7509P)

TO:		Kelly O’Rourke, Risk Assessor

		Registration Action Branch 3

Health Effects Division (7509P)

and

Tony Kish/Janet Whitehurst

Fungicide Branch

Registration Division (7505P)

Executive Summary

ion Model (DEEM-FCID™), Version 2.03, which uses food consumption data
from the U.S. Department of Agriculture’s Continuing Surveys of Food
Intakes by Individuals (CSFII) from 1994-1996 and 1998.  The analyses
were performed to support the proposed FIFRA §3 registration of the
fungicide, cyazofamid, on carrot root. 

Acute and chronic dietary risk assessments have been conducted
previously for turf and ornamentals (D332427, Susan L. Stanton,
9/14/06).   For the purpose of the new use pattern,  HED has concluded
that it would not be necessary to amend the previous dietary risk
assessment except for the addition of the new food item (carrot) into
the residue file.  This decision is based on the determination by the
Environmental Effects Division that the maximum estimated Drinking Water
Concentration (EDWCs) for parent cyazofamid and degradates CCIM, CCIM-AM
and CTCA for the carrot use pattern in comparison to turf and ornamental
use pattern, are much lower as values are 17% for the surface water
acute, 5% for the surface water non-cancer chronic, and 7% for the
cancer chronic.  Furthermore, the acute/chronic value for ground water
is 25% of the values assigned for the turf and ornamentals use pattern.
(D342613, Mohammed A. Ruhman, 2/21/08).

Therefore, the dietary risk assessment on carrot will be conducted using
the same information and parameters used for the dietary risk assessment
on turf and ornamentals.  The dietary and chronic exposure assessments
will be performed on food + drinking water only. 

 

The unrefined, Tier 1 acute and chronic analyses assumed that cyazofamid
residues are present in all registered food commodities at tolerance
levels and that 100% of all commodities are treated.  All processing
factors were set to 1, based on the results of processing studies
demonstrating that residues of cyazofamid in processed commodities would
not exceed the raw agricultural commodity (RAC) tolerances.

Drinking water was incorporated directly into the dietary assessment
using the estimated drinking water concentrations (EDWC) for the
terminal degradate (CTCA) in surface water.  EDWCs were generated using
the PRZM-EXAMS models.  For the acute assessment, the 1-in-10 year
annual peak concentration of 136 ppb was used; for the chronic
assessment, the 1-in-10 year annual mean value of 133 ppb was used.

Acute Dietary Exposure Results

The Tier 1 acute dietary exposure assessment was performed for females
13-49 years old only, since an acute endpoint of concern was not
identified for the general U.S. population.  Based on the assumptions
described above, acute dietary exposure of females 13-49 years old is
well below HED’s level of concern at the 95th percentile of exposure. 
Combined dietary exposure from food and drinking water is estimated at
0.009153 mg/kg/day, equivalent to <1% of the acute Population Adjusted
Dose (aPAD).  

Chronic Dietary Exposure Results

Chronic dietary exposure estimates for food and drinking water combined
are also well below HED’s level of concern.  Using the DEEM-FCID
software, dietary exposure is estimated at 0.003797 mg/kg/day for the
general U.S. population (<1% of the chronic Population Adjusted Dose
(cPAD) and 0.010691 mg/kg/day (1.1% of the cPAD) for infants <1 year
old, the population subgroup with the highest estimated chronic dietary
exposure to cyazofamid.  

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to the reference dose (RfD) divided by the
special Food Quality Protection Act (FQPA) Safety Factor.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  References which
discuss the acute and chronic risk assessments in more detail are
available on the EPA/pesticides web site:  “Available Information on
Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web
link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see
SOP 99.6 (8/20/99).

The most recent HED dietary risk assessment for cyazofamid (D332427, S.
Stanton, 9/14/2006) 

was conducted to support the FIFRA §3 registration on turf and
ornaments.  As in the assessment 

for turf and ornaments, this current assessment incorporates drinking
water directly into the

dietary analyses.

 

II.	Food Residue Information

Residues of Concern:  The HED Metabolism Assessment Review Committee
(MARC) concluded in a meeting on 2/18/04 that for the risk assessment
and tolerance expression, parent and the metabolite designated as CCIM
are the residues of concern for plant commodities.  The MARC also
concluded that cyazofamid and the metabolites designated as CCIM,
CCIM-AM and CTCA are considered to be the major residues in water and
should be included in the drinking water risk assessment.  The current
uses of cyazofamid fall under 40 CFR §180.6(a)(3) (i.e., there is no
reasonable expectation of finite residues in livestock commodities).  

Tolerances:  Tolerances have been established under 40 CFR §180.601 for
the combined residues of  cyazofamid and its metabolite CCIM
[4-chloro-5-(4-methylphenyl)-1H-imidazole-2-carbonitrile] in or on
cucurbit vegetables (Group 9) (0.1 ppm), imported wine grapes (1.5 ppm),
potato (0.02 ppm) and tomato (0.2 ppm).  Turf and ornamentals (non-food
use sites) did not require establishment of additional tolerances.

Residue Data used for the Acute and Chronic Assessments:  The unrefined,
Tier 1 acute and chronic analyses assumed that cyazofamid residues are
present in/on all registered food commodities at tolerance levels and
that 100% of all commodities are treated.  Adequate processing data are
available for grapes (MRID 45409028), potatoes (MRID 45409033) and
tomatoes (MRID 45409031).  The results of these studies indicate that
residues in processed commodities will not exceed the raw agricultural
commodity (RAC) tolerances (A. Acierto; 

D285680; 2/20/04).  Therefore, all processing factors were set to 1x.  
There were no processing data for carrot. The food residue data used in
the acute and chronic analyses are summarized below in Table 1.



Table 1.  Residue Data used in the Acute and Chronic Dietary Analyses
for Cyazofamid

Commodity	Tolerance	Percent Crop Treated	Processing Factors

Carrot, root	0.09 ppm	100	NA*

*Not applicable

 Drinking Water Data

Reference: Estimated Drinking Water Concentrations of Parent Cyazofamid
and its Degradates CCIM, CCIM-AM and CTCA for Use in Human Health Risk
Assessment (Turf and ornamentals use pattern); M. Ruhman; 9/6/06; DP
Num: 319466).

The Environmental Effects Division determined that the maximum estimated
Drinking Water Concentration (EDWCs) for parent cyazofamid and
degradates CCIM, CCIM-AM and CTCA for the carrot use pattern in
comparison to turf and ornamental use pattern, are much lower as values
are 17% for the surface water acute, 5% for the surface water non-cancer
chronic, and 7% for the cancer chronic.  Furthermore, the acute/chronic
value for ground water is 25% of the values assigned for the turf and
ornamentals use pattern. (DP Number 342613, Mohammed A. Ruhman,
2/21/08).  Therefore the EDWCs from EFED’s previous drinking water
assessment for turf and ornamentals were used in this dietary assessment
as described below.

The Environmental Fate and Effects Division (EFED) calculated screening
level surface water and ground water estimates for cyazofamid and its
degradates using linked PRZM/EXAMS models and the SCI-GROW model,
respectively. The drinking water models and their descriptions are
available at the EPA internet site:   HYPERLINK
"http://www.epa.gov/oppefed1/models/water/" 
http://www.epa.gov/oppefed1/models/water/ .  Estimated drinking water
concentrations (EDWCs) are presented in Table 2 for three scenarios as
follows:

(1) 1st scenario (parent) assuming application of the maximum rate as
parent;

(2) 2nd scenario (each of the degradates CCIM, CCIM-AM, and CTCA)
assuming application of the molar equivalent of the parent for each of
the degradate by apportioning the rate between the degradates based on
molecular ratios and adjusted maximums found in fate studies; and

(3) 3rd scenario (the terminal degradate CTCA) assuming application of
100% molar conversions of the parent into this terminal degradate CTCA.

Table 2.  Resulting Maximum Surface/Ground water EDWCs for cyazofamid
and each of its Major Degradates

Scenario	Chemical	Surface water EDWCs (ppb)	Ground water EDWC (ppb)

Acute

(1-in-10 yr. peak)	Chronic

 (1-in-10 yr. mean)

	1st  Scenario	Parent	14.362	0.377	0.01180

2nd  Scenario 	CCIM	17.106	12.094	0.00061

	CCIM-AM	6.699	6.312	0.00270

	CTCA	16.716	11.993	0.52300

3rd  Scenario 	CTCA	136.242	133.458	2.18000

The highest acute (peak) and chronic (mean) EDWCs were estimated for
surface water using the PRZM/EXAMS model.  For the purpose of this Tier
1 dietary assessment, HED used the highest calculated screening EDWCs
for surface water based on the 3rd modeling scenario: 136 ppb for the
acute analysis and 133 ppb for the chronic analysis.  This approach may
significantly overestimate dietary exposure to cyazofamid from drinking
water; however, since estimated aggregate food and drinking water
exposures using this approach are well below the acute and chronic
levels of concern, additional refinements were not deemed necessary. 
For both the
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IV.	DEEM-FCID™ Program and Consumption Information

Cyazofamid acute and chronic dietary exposure assessments were conducted
using the Dietary Exposure Evaluation Model software with the Food
Commodity Intake Database (DEEM-FCID™, Version 2.03), which
incorporates consumption data from USDA’s Continuing Surveys of Food
Intakes by Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98
data are based on the reported consumption of more than 20,000
individuals over two non-consecutive survey days.  Foods “as
consumed” (e.g., apple pie) are linked to EPA-defined food commodities
(e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicly available recipe
translation files developed jointly by USDA/ARS and EPA.  For chronic
exposure assessment, consumption data are averaged for the entire U.S.
population and within population subgroups, but for acute exposure
assessment are retained as individual consumption events.  Based on
analysis of the 1994-96, 98 CSFII consumption data, which took into
account dietary patterns and survey respondents, HED concluded that it
is most appropriate to report risk for the following population
subgroups: the general U.S. population, all infants (<1 year old),
children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49,
females 13-49, and adults 50+ years old.

For chronic dietary exposure assessments, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., only those who reported
eating relevant commodities/food forms) and a per-capita (i.e., those
who reported eating the relevant commodities as well as those who did
not) basis.  In accordance with HED policy, per capita exposure and risk
are reported for all tiers of analysis.  However, for Tiers 1 and 2, any
significant differences in user vs. per capita exposure and risk are
specifically identified and noted in the risk assessment.

V.	Toxicological Information

On February 10, 2004, the HIARC evaluated the toxicology database for
cyazofamid with regard to the acute and chronic reference doses (RfDs). 
The doses and toxicological endpoints selected for dietary exposure
scenarios are summarized in Table 3.  

.

Table 3.  Summary of Cyazofamid Toxicological Doses and Endpoints for
Dietary Risk Assessment.

Exposure

Scenario	

Dose Used in Risk Assessment, UF 	

FQPA SF and Level of Concern for Risk Assessment	

Study and Toxicological Effects

Acute Dietary

(Females 13-50 years of age)	

NOAEL = 100 mg/kg

UF = 100

Acute RfD = 1.0 mg/kg	

FQPA SF = 1X

aPAD = acute RfD

              FQPA SF

= 1.0 mg/kg	

Rat Prenatal Developmental Toxicity (MRID 45408933)

LOAEL = 1,000 mg/kg based on developmental toxicity findings of
increased incidence of bent ribs.

Acute Dietary

(General population including infants and children)	

NOAEL = NA

UF = NA

Acute RfD = NA 	

FQPA SF =  NA

aPAD = acute RfD

              FQPA SF

= NA	

Not Required.  No adverse effects were observed which could be
attributed to a single-dose exposure.

Chronic Dietary

(All populations)	

NOAEL= 94.8 mg/kg/day

UF = 100

Chronic RfD = 0.95

 mg/kg/day	

FQPA SF = 1X

cPAD = chronic RfD

               FQPA SF

= 0.95 mg/kg/day	

18-Month Mouse Oral Carcinogenicity (MRID 45408932)

LOAEL = 985 mg/kg/day based on increased skin lesions.

UF = uncertainty factor, FQPA SF = Special FQPA safety factor, NOAEL =
no-observed-adverse-effect-level, LOAEL =
lowest-observed-adverse-effect-level, PAD = population adjusted dose (a
= acute, c = chronic) RfD = reference dose, NA = Not Applicable

VI.	Results/Discussion 

PAD.  The DEEM-FCID™ analyses estimate the dietary exposure of the
U.S. population and various population subgroups.  The acute exposure
results are reported in Tables 4 and 5 for females 13-49 only.  The
chronic results reported in Table 6 are for the general U.S. Population,
all infants (<1 year old), children 1-2, children 3-5, children 6-12,
youth 13-19, females 13-49, adults 20-49, and adults 50+ years.  

Results of Acute Dietary Exposure Analysis

The Tier 1 acute dietary (food + drinking water) exposure assessment was
performed for females 13-49 years old only, since an acute endpoint of
concern was not identified for the general population.  Based on the
assumptions described above in sections II and III, acute dietary
exposure of females 13-49 years old is well below HED’s level of
concern (i.e., <100% of the aPAD of 1.0 mg/kg).  The combined dietary
exposure from food and drinking water is estimated at 0.009153 mg/kg/day
(equivalent to <1% of the aPAD), at the 95th percentile of exposure, the
appropriate regulatory statistic for Tier 1 dietary assessments.  It is
noted that estimated acute dietary exposure of females 13-49 years old
is also well below HED’s level of concern at the 99th ant 99.9th
percentiles of exposure as shown in Table 4.

Table 4.  Results of Acute Dietary Exposure Analysis for Food and
Drinking Water at the 95th Percentile of Exposure using DEEM FCID

Population Subgroup	aPAD (mg/kg/day)	95th Percentile	99th Percentile
99.9th Percentile

Exposure (mg/kg/day)	% aPAD	Exposure (mg/kg/day)	% aPAD	Exposure
(mg/kg/day)	% aPAD

Females 13-49 years old 	1.0	0.009153	<1	0.015222	1.52	0.022308	2.2

Results of Chronic Dietary Exposure Analysis

-FCID™ software are well below HED’s level of concern for the
general U.S. population and each of the population subgroups.  Dietary
exposure was estimated at 0.003797 mg/kg/day for the U.S. population
(<1% of the cPAD) and 0.010691 mg/kg/day (1.1% of the cPAD) for the most
highly exposed population subgroup (infants <1 year old).  The estimated
exposures/risks for food and drinking water are summarized in Table 5
for all populations.

Table 5.  Summary of Chronic Dietary Exposure and Risk for Cyazofamid1

Population Subgroup	    Exposure

(mg/kg/day)	% cPAD

General U.S. Population	0.003797	<1

All Infants (< 1 year old)1	0.010691	1.1

Children 1-2 years old	0.008923	<1

Children 3-5 years old	0.006946	<1

Children 6-12 years old	0.003992	<1

Youth 13-19 years old	0.002571	<1

Adults 20-49 years old	0.003284	<1

Adults 50+ years old	0.003500	<1

Females 13-49 years old	0.003307	<1

 1The population subgroup with the highest estimated chronic dietary
(food + drinking water)

  exposure and  risk is indicated by bold text.

		     .

VII.	Characterization of Inputs/Outputs

These acute and chronic dietary exposure and risk estimates are
conservative since they assume that 100% of crops are treated with
cyazofamid and that residues are present at tolerance levels.  In
addition, drinking water exposure estimates were based on screening
level estimates generated by the PRZM-EXAMS model.  Dietary exposure
estimates could be refined through the use of anticipated residues and
percent crop treated data, as well as refined estimated drinking water
concentrations.  However, since estimated exposures and risks using
conservative assumptions are well below HED’s level of concern, such
refinement is not warranted.

VIII.	Conclusions

These unrefined, Tier 1 dietary exposure analyses using DEEM-FCID™ 
indicate that acute and chronic dietary exposures to cyazofamid from
food and drinking water are well below HED’s level of concern for this
pesticide.  The estimated acute exposure of females 13-49 years old, the
only population subgroup of concern for acute exposure, represents <1%
of the aPAD at the 95th percentile of exposure.  Estimated chronic
dietary exposures are less than or equal to 1.1% of the cPAD for the
general U.S. population and all population subgroups.

IX.		List of Attachments

	Acute Food + Drinking Water Input File

	Acute Food + Drinking Water Results File

	Chronic Food + Drinking Water Input File

	Chronic Food + Drinking Water Results File

ACUTE FOOD + DRINKING WATER INPUT FILE

U.S. Environmental Protection Agency                                Ver.
2.02

DEEM-FCID Acute analysis for CYAZOFAMID

Residue file name: C:\Documents and
Settings\aacierto\Desktop\DEEM.2008\acute cyazofamid food + water.R98

Analysis Date 03-06-2008            Residue file dated:
03-05-2008/15:08:44/8

Reference dose: aRfD = 1 mg/kg bw/day  NOEL = 100 mg/kg bw/day

Comment: Acute Food + Drinking Water using CTCA Drinking Water estimate
(scenario #3): Females 13-49 only.

------------------------------------------------------------------------
-----

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Food Name                         (ppm)       #1    #2   

-------- ---- ---------------------------  ----------  ------ ------ 
-------

09020210 9B   Balsam pear                        0.100000   1.000  1.000

09010750 9A   Cantaloupe                         0.100000   1.000  1.000

01010780 1AB  Carrot                             0.090000   1.000  1.000

01010781 1AB  Carrot-babyfood                    0.090000   1.000  1.000

09010800 9A   Casaba                             0.100000   1.000  1.000

09020880 9B   Chayote, fruit                     0.100000   1.000  1.000

09021020 9B   Chinese waxgourd                   0.100000   1.000  1.000

09021350 9B   Cucumber                           0.100000   1.000  1.000

95001750 O    Grape                              1.500000   1.000  1.000

95001760 O    Grape, juice                       1.500000   1.000  1.000

95001761 O    Grape, juice-babyfood              1.500000   1.000  1.000

95001770 O    Grape, leaves                      1.500000   1.000  1.000

95001780 O    Grape, raisin                      1.500000   1.000  1.000

95001790 O    Grape, wine and sherry             1.500000   1.000  1.000

09011870 9A   Honeydew melon                     0.100000   1.000  1.000

01032960 1C   Potato, chips                      0.020000   1.000  1.000

01032970 1C   Potato, dry (granules/ flakes)     0.020000   1.000  1.000

01032971 1C   Potato, dry (granules/ flakes)-b   0.020000   1.000  1.000

01032980 1C   Potato, flour                      0.020000   1.000  1.000

01032981 1C   Potato, flour-babyfood             0.020000   1.000  1.000

01032990 1C   Potato, tuber, w/peel              0.020000   1.000  1.000

01032991 1C   Potato, tuber, w/peel-babyfood     0.020000   1.000  1.000

01033000 1C   Potato, tuber, w/o peel            0.020000   1.000  1.000

01033001 1C   Potato, tuber, w/o peel-babyfood   0.020000   1.000  1.000

09023080 9B   Pumpkin                            0.100000   1.000  1.000

09023090 9B   Pumpkin, seed                      0.100000   1.000  1.000

09023560 9B   Squash, summer                     0.100000   1.000  1.000

09023561 9B   Squash, summer-babyfood            0.100000   1.000  1.000

09023570 9B   Squash, winter                     0.100000   1.000  1.000

09023571 9B   Squash, winter-babyfood            0.100000   1.000  1.000

08003740 8    Tomatillo                          0.200000   1.000  1.000

08003750 8    Tomato                             0.200000   1.000  1.000

08003751 8    Tomato-babyfood                    0.200000   1.000  1.000

08003760 8    Tomato, paste                      0.200000   1.000  1.000

08003761 8    Tomato, paste-babyfood             0.200000   1.000  1.000

08003770 8    Tomato, puree                      0.200000   1.000  1.000

08003771 8    Tomato, puree-babyfood             0.200000   1.000  1.000

08003780 8    Tomato, dried                      0.200000   1.000  1.000

08003781 8    Tomato, dried-babyfood             0.200000   1.000  1.000

08003790 8    Tomato, juice                      0.200000   1.000  1.000

95003800 O    Tomato, Tree                       0.200000   1.000  1.000

86010000 O    Water, direct, all sources         0.136000   1.000  1.000

86020000 O    Water, indirect, all sources       0.136000   1.000  1.000

09013990 9A   Watermelon                         0.100000   1.000  1.000

09014000 9A   Watermelon, juice                  0.100000   1.000  1.000

ACUTE FOOD + DRINKING WATER  RESULT FILE

U.S. Environmental Protection Agency                              Ver.
2.02

DEEM-FCID ACUTE Analysis for CYAZOFAMID                       (1994-98
data)

Residue file:acute cyazofamid food + water.R98 Adjustment factor #2 NOT
used.

Analysis Date: 03-05-2008/15:10:28  Residue file dated:
03-05-2008/15:08:44/8

NOEL (Acute) = 100.000000 mg/kg body-wt/day

Daily totals for food and foodform consumption used.

Run Comment: "Acute Food + Drinking Water using CTCA Drinking Water
estimate 

scenario #3): Females 13-49 only."

========================================================================
=====

Summary calculations:

      95th Percentile             99th Percentile             99.9th
Percentile

 Exposure   aRfD     MOE     Exposure    aRfD     MOE    Exposure   
aRfD      MOE  

---------- ------- -------- ---------- ------- ---------- --------
--------

Seniors 55+:

  0.007968    0.80   12550    0.013217    1.32    7565    0.022816   
2.28    4382  

Children 1-2 yrs:

  0.029462    2.95    3394    0.058318    5.83    1714    0.166583  
16.66     600  

Children 3-5 yrs:

  0.020090    2.01    4977    0.039005    3.90    2563    0.077774   
7.78    1285  

Children 6-12 yrs:

  0.010952    1.10    9130    0.019358    1.94    5165    0.043834   
4.38    2281  

Youth 13-19 yrs:

  0.007340    0.73   13623    0.013031    1.30    7673    0.025155   
2.52    3975  

Adults 20-49 yrs:

  0.008756    0.88   11420    0.014869    1.49    6725    0.022728   
2.27    4399  

Adults 50+ yrs:

  0.007981    0.80   12529    0.013170    1.32    7593    0.022616   
2.26    4421  

Females 13-49 yrs:

  0.009153    0.92   10925    0.015222    1.52    6569    0.022308   
2.23    4482  



CHRONIC FOOD + DRINKING WATER INPUT FILE

Filename: C:\Documents and Settings\aacierto\Desktop\DEEM.2008\chronic
cyazofamid food + water.R98

Chemical: cyazofamid

RfD(Chronic): .95 mg/kg bw/day  NOEL(Chronic): 94.8 mg/kg bw/day

RfD(Acute): 1 mg/kg bw/day  NOEL(Acute):  100 mg/kg bw/day

Date created/last modified: 03-05-2008/14:17:03/8          Program ver.
2.03

Comment: Chronic Food + Drinking Water using CTCA Drinking Water
estimate (scenario #3)

------------------------------------------------------------------------
-----

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- ---------------------------  ----------  ------ ------ 
-------

09020210 9B   Balsam pear                        0.100000   1.000  1.000
 

09010750 9A   Cantaloupe                         0.100000   1.000  1.000
 

01010780 1AB  Carrot                             0.090000   1.000  1.000
 

01010781 1AB  Carrot-babyfood                    0.090000   1.000  1.000
 

09010800 9A   Casaba                             0.100000   1.000  1.000
 

09020880 9B   Chayote, fruit                     0.100000   1.000  1.000
 

09021020 9B   Chinese waxgourd                   0.100000   1.000  1.000
 

09021350 9B   Cucumber                           0.100000   1.000  1.000
 

95001750 O    Grape                              1.500000   1.000  1.000
 

95001760 O    Grape, juice                       1.500000   1.000  1.000
 

95001761 O    Grape, juice-babyfood              1.500000   1.000  1.000
 

95001770 O    Grape, leaves                      1.500000   1.000  1.000
 

95001780 O    Grape, raisin                      1.500000   1.000  1.000
 

95001790 O    Grape, wine and sherry             1.500000   1.000  1.000
 

09011870 9A   Honeydew melon                     0.100000   1.000  1.000
 

01032960 1C   Potato, chips                      0.020000   1.000  1.000
 

01032970 1C   Potato, dry (granules/ flakes)     0.020000   1.000  1.000
 

01032971 1C   Potato, dry (granules/ flakes)-b   0.020000   1.000  1.000
 

01032980 1C   Potato, flour                      0.020000   1.000  1.000
 

01032981 1C   Potato, flour-babyfood             0.020000   1.000  1.000
 

01032990 1C   Potato, tuber, w/peel              0.020000   1.000  1.000
 

01032991 1C   Potato, tuber, w/peel-babyfood     0.020000   1.000  1.000
 

01033000 1C   Potato, tuber, w/o peel            0.020000   1.000  1.000
 

01033001 1C   Potato, tuber, w/o peel-babyfood   0.020000   1.000  1.000
 

09023080 9B   Pumpkin                            0.100000   1.000  1.000
 

09023090 9B   Pumpkin, seed                      0.100000   1.000  1.000
 

09023560 9B   Squash, summer                     0.100000   1.000  1.000
 

09023561 9B   Squash, summer-babyfood            0.100000   1.000  1.000
 

09023570 9B   Squash, winter                     0.100000   1.000  1.000
 

09023571 9B   Squash, winter-babyfood            0.100000   1.000  1.000
 

08003740 8    Tomatillo                          0.200000   1.000  1.000
 

08003750 8    Tomato                             0.200000   1.000  1.000
 

08003751 8    Tomato-babyfood                    0.200000   1.000  1.000
 

08003760 8    Tomato, paste                      0.200000   1.000  1.000
 

08003761 8    Tomato, paste-babyfood             0.200000   1.000  1.000
 

08003770 8    Tomato, puree                      0.200000   1.000  1.000
 

08003771 8    Tomato, puree-babyfood             0.200000   1.000  1.000
 

08003780 8    Tomato, dried                      0.200000   1.000  1.000
 

08003781 8    Tomato, dried-babyfood             0.200000   1.000  1.000
 

08003790 8    Tomato, juice                      0.200000   1.000  1.000
 

95003800 O    Tomato, Tree                       0.200000   1.000  1.000
 

86010000 O    Water, direct, all sources         0.133000   1.000  1.000
 

86020000 O    Water, indirect, all sources       0.133000   1.000  1.000
 

09013990 9A   Watermelon                         0.100000   1.000  1.000
 

09014000 9A   Watermelon, juice                  0.100000   1.000  1.000
 

CHRONIC FOOD + DRINKING WATER RESULT FILE

U.S. Environmental Protection Agency                             Ver.
2.00

DEEM-FCID Chronic analysis for CYAZOFAMID                    (1994-98
data)

Residue file name: C:\Documents and
Settings\aacierto\Desktop\DEEM.2008\chronic cyazofamid food + water.R98 
               Adjustment factor #2 NOT used.

Analysis Date 03-05-2008/14:48:32 Residue file dated:
03-05-2008/14:17:03/8

Reference dose (RfD, Chronic) = .95 mg/kg bw/day

NOEL (Chronic) = 94.8 mg/kg bw/day

COMMENT 1: Chronic Food + Drinking Water using CTCA Drinking Water
estimate (scenario #3)

========================================================================
=====

                    Total exposure by population subgroup

------------------------------------------------------------------------
-----

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg       Margin of  
Percent 

           Subgroup                       body wt/day   Exposure 1/  of
RfD 

--------------------------------------   -------------  ---------- 
---------

U.S. Population (total)                     0.003797       24,966       
0.4%

U.S. Population (spring season)             0.003724       25,457       
0.4%

U.S. Population (summer season)             0.004126       22,978       
0.4%

U.S. Population (autumn season)             0.003653       25,954       
0.4%

U.S. Population (winter season)             0.003682       25,746       
0.4%

Northeast region                            0.003714       25,523       
0.4%

Midwest region                              0.003816       24,844       
0.4%

Southern region                             0.003529       26,865       
0.4%

Western region                              0.004279       22,157       
0.5%

Hispanics                                   0.004076       23,261       
0.4%

Non-hispanic whites                         0.003777       25,101       
0.4%

Non-hispanic blacks                         0.003519       26,940       
0.4%

Non-hisp/non-white/non-black                0.004273       22,186       
0.4%

All infants (< 1 year)                      0.010691        8,867       
1.1%

Nursing infants                             0.004043       23,450       
0.4%

Non-nursing infants                         0.013215        7,174       
1.4%

Children 1-6  yrs                           0.007308       12,972       
0.8%

Children 7-12 yrs    
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$

Females 13-50 yrs                           0.003453       27,456       
0.4%

Females 13+ (preg/not nursing)              0.003200       29,621       
0.3%

Females 13+ (nursing)                       0.004541       20,877       
0.5%

Males 13-19 yrs                             0.002546       37,232       
0.3%

Males 20+ yrs                               0.003155       30,049       
0.3%

Seniors 55+                                 0.003515       26,973       
0.4%

Children 1-2 yrs                            0.008923       10,625       
0.9%

Children 3-5 yrs                            0.006946       13,649       
0.7%

Children 6-12 yrs                           0.003992       23,746       
0.4%

Youth 13-19 yrs                             0.002571       36,876       
0.3%

Adults 20-49 yrs                            0.003284       28,865       
0.3%

Adults 50+ yrs                              0.003500       27,083       
0.4%

Females 13-49 yrs                           0.003307       28,664       
0.3%

------------------------------------------------------------------------
----

Cyazofamid Dietary Exposure Assessment		DP Number: 343442			PC Code:
085651

________________________________________________________________________
____________________ൟ