Document ID: EPA-HQ-OPP-2010-0385-0004
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2011-02-02T05:00Z

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<SPAN STYLE="color:#000000;position:absolute;left:164.90pt;top:95.70pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">UNITED STATES ENVIRONMENTAL PROTECTION AGENCY</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:243.50pt;top:107.35pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">WASHINGTON, D.C. 20460</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:404.35pt;top:130.65pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">OFFICE OF CHEMICAL SAFETY</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:405.20pt;top:141.30pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">AND POLLUTION PREVENTION</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:166.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><u><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">MEMORANDUM</FONT></FONT></u></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:194.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">December 1, 2010</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:236.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">SUBJECT: Cyprodinil Human Health Risk Assessment for Amended Use and Amended</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:250.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Tolerance Petition for Pome Fruit</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:86.40pt;top:278.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">PC Code: 288202</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:333.90pt;top:278.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">DP Barcode: D383614</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:86.40pt;top:291.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">Decision No.:  428920</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:333.90pt;top:291.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">Registration No.: 100-828 and 100-1317</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:86.40pt;top:304.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">Petition No.: 0F7696</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:333.90pt;top:304.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">Regulatory Action: Amended Section 3</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:86.40pt;top:317.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">Risk Assessment Type:  Single Chemical Aggregate</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:333.90pt;top:317.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">Case No.:  7025</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:86.40pt;top:330.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">TXR No.: NA</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:333.90pt;top:330.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">CAS No.: 121552-61-2</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:86.40pt;top:343.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">MRID No.:  NA</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:333.90pt;top:343.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">40 CFR:  180.532</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:370.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">FROM:</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:370.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Becky Daiss, Biologist</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:384.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Bonnie Cropp-Kohlligian, Environmental Scientist</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:398.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Thurston Morton, Chemist</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:412.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Risk Assessment Branch 4</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:426.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Health Effects Division (7509P)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:454.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">THROUGH:  Susan V. Hummel, Branch Senior Scientist</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:468.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Risk Assessment Branch 4, HED (7509P)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:496.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">TO:</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:496.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Lisa Jones, Risk Manager Reviewer</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:510.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Fungicide Branch</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:524.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Registration Division (7505P)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:552.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">This document provides Health Effects Division’s (HED’s) risk assessment of the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:566.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">amended Section 3 registration for use of cyprodinil on pome fruit.  Supporting documents are</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:580.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">listed below.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:619.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Residue Chemistry Assessment – B. Cropp-Kohlligian, D378920, 10/27/10</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:633.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Dietary and Drinking Water Exposure Assessment – T. Morton, D384458, 12/01/10</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:647.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Drinking Water Exposure Assessment – J. Melendez, D428848, 11//8/10</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:676.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">TABLE OF CONTENTS</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:275.90pt;top:706.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 1 of 38</FONT></FONT></FONT></SPAN>
<span style="color:#000000;background-color:#ffffff;position:absolute;left:0.00pt;top:0.00pt;z-index:-1;"><img style="width:612pt;height:792pt;" src="outputfile-892646128.htm_files\outputfile-892646128_background0.png"></span>
<SPAN STYLE="position:absolute;left:71.76pt;top:792.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:275.90pt;top:1498.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 2 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:504.00pt;top:864.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">pg.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:878.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">1.0</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:878.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">EXECUTIVE SUMMARY .................................................................................................4</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:892.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">2.0 INGREDIENT PROFILE ....................................................................................................7</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:906.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">2.1 Registered Products .............................................................................................................7</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:920.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">2.2</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:920.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Registered and Proposed New Uses ....................................................................................7</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:934.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">2.3</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:934.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Structure, Nomenclature and Physical/Chemical Properties ...............................................8</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:962.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.0 HAZARD CHARACTERIZATION/ASSESSMENT ........................................................9</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:976.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.1 Hazard Characterization .....................................................................................................9</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:990.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.2</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:990.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">FQPA Hazard Considerations ...........................................................................................10</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1004.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.2.1 Neurotoxicity .......................................................................................................10</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1018.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.2.2</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:1018.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Developmental Toxicity  ......................................................................................10</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1032.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.2.3 Reproductive Toxicity ..........................................................................................11</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1046.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.2.4</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:1046.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Pre-and/or Postnatal Toxicity ................................................................................12</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1060.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.2.5    FQPA Factor ..........................................................................................................12</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1074.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.3</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1074.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Toxicity Endpoint Selection ..............................................................................................12</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1088.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.3.1    Acute Reference Dose – Females 13- 49...............................................................12</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1102.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.3.2</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:1102.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Acute Reference Dose – General Population ........................................................13</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1116.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.3.3</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:1116.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Chronic Reference Dose – All Populations ...........................................................13</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1130.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.3.4</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:1130.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Classification of Carcinogenic Potential................................................................14</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1144.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.4</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1144.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Recommendation for Aggregate Exposure........................................................................14</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1158.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.5</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1158.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Summary of Endpoints Selected for Risk Assessment......................................................14</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1172.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.6 Endocrine Disruption.........................................................................................................15</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1200.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.0</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:107.95pt;top:1200.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">DIETARY AND DRINKING WATER EXPOSURE ASSESSMENT ............................16</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1214.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1214.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Residue Chemistry Profile.................................................................................................16</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1228.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.1  Metabolism in Primary Crops, Livestock and Rotational Crops...........................16</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1242.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.2</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:1242.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Residues of Concern ..............................................................................................16</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1256.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.3</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:1256.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Residue Analytical Method ...................................................................................16</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1270.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.4</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:1270.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Residues in Crops ..................................................................................................17</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1284.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.5</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:1284.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Residues in Livestock ............................................................................................17</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1297.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.6    Residues in Processed Commodities .....................................................................18</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1311.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.7    Residues in Rotational Crops.................................................................................18</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1325.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.8 Storage Stability.....................................................................................................18</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1353.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.2</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1353.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Drinking Water Profile ......................................................................................................18</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1367.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.2.1</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:1367.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Environmental Fate and Transport ........................................................................18</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1381.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.2.2  Estimated Drinking Water Concentrations............................................................19</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1395.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.3</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1395.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Dietary and Drinking Water Exposure and Risk ...............................................................19</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1409.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.3.1  Acute Dietary and Drinking Water Analysis.........................................................19</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1423.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.3.2  Chronic Dietary and Drinking Water Analysis......................................................20</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1451.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">5.0</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:107.95pt;top:1451.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">AGGREGATE EXPOSURE AND RISK ASSESSMENT ...............................................20</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:1584.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:275.90pt;top:2290.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 3 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1656.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">6.0 CUMULATIVE RISK.......................................................................................................21</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1684.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">7.0 DATA NEEDS...................................................................................................................22</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1698.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">7.1 Toxicity Data .....................................................................................................................22</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1726.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">APPENDICES</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1740.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">A. GUIDELINE TOXICOLOGY DATA SUMMARY .........................................................23</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1754.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">A.1</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.05pt;top:1754.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Guideline Data Requirements................................................................................23</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1768.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">A.2</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.05pt;top:1768.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Toxicity Profiles ....................................................................................................24</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1782.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">B. STUDIES REVIEWED FOR ETHICAL CONDUCT ......................................................29</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1796.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">C.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:1796.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">ADDITIONAL TOXICITY STUDIES .............................................................................30</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1810.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">D. METABOLIC PROFILE...................................................................................................34</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:1824.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">E. TOXICITY STUDY REFERENCES ................................................................................33</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:2376.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:275.90pt;top:3082.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 4 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2462.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">1.0</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:107.95pt;top:2462.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">EXECUTIVE SUMMARY</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:2490.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">This assessment provides information to support an amended Section 3 registration for</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2504.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">the use of cyprodinil on pome fruit.  This document addresses the dietary and drinking water</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2518.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">exposure and risk associated with currently registered uses and the proposed new use of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2532.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">cyprodinil.  It provides a reassessment of tolerances (pesticide residue limits in food) to ensure</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2546.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">that they meet the safety standard established by the Food Quality Protection Act (FQPA) of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2560.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">1996.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2588.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Use Profile</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:2616.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Cyprodinil (4-cyclopropyl-6-methyl-N-phenyl-2-pyrimidinamine) is a systemic anilino-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2630.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">pyrimidine fungicide.  Permanent tolerances are established (40 CFR §180.532(a)) for residues</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2644.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">of cyprodinil per se in/on a variety of crop commodities, at levels ranging from 0.02 ppm in/on</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2658.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">almonds to 340 ppm in citrus oil.  Cyprodinil is a systemic fungicide and is active through</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2672.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">inhibition of methionine biosynthesis.  Cyprodinil is applied to food crops with aircraft and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2686.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">ground application equipment.  Cyprodinil is used on ornamentals and landscaped areas on golf</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2700.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">courses and around residential, institutional, public, commercial and industrial buildings, parks,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2714.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">recreational areas and athletic fields.  It is applied to non-food areas with ground-boom and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2728.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">handheld spray equipment.  Since the label does not limit use to “professional” or certified</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2742.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">applicators, the Agency believes it is possible for residential “handlers” to obtain and to apply</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2756.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">the product.  Residential exposures are limited to residential applicators since cyprodinil is used</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2770.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">on ornamentals but not on turf.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2798.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Proposed Amended Uses</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:2826.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">In conjunction with this petition, Syngenta Crop Protection, Inc. is requesting an</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2840.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">amended use of their 75% water-dispersible granular (WDG) formulation of cyprodinil,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2854.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Vangard™ Fungicide (EPA Reg. No. 100-828), on pome fruit to reduce the preharvest interval</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2868.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">(PHI) from 72- to 0-days; the current maximum use rate of this product on pome fruit (0.23 lb</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2882.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">ai/A/application (1.4 lb ai/A/season)) will remain unchanged.  They are also requesting an</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2896.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">amended use of their emulsion [oil] in water (EW) formulation of cyprodinil/difenoconazole,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2910.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Inspire Super</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:138.40pt;top:2908.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">™</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:149.20pt;top:2910.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Fungicide (EPA Reg. No. 100-1317), on pome fruit to increase the maximum</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2924.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">use rate of cyprodinil from 0.04 lb ai/A/application (0.16 lb ai/A/season of cyprodinil from</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2938.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Inspire Super™) to 0.20 lb ai/A/application (1.0 lb ai/A/season of cyprodinil from Inspire</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2952.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Super™) and reduce the PHI from 86- to 14-days.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:2979.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">In addition, the petitioner, Syngenta Crop Protection, Inc. proposes to amend the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:2993.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">tolerance in 40 CFR §180.532 for residues of the fungicide cyprodinil (2-pyrimidinamine, 4-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3007.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">cyclopropyl-6-methyl-N-phenyl) in or on fruit, pome, group 11 from 0.1 ppm to 1.7 ppm.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:3168.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:275.90pt;top:3874.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 5 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3240.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Hazard Identification</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:3268.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">The toxicology database for cyprodinil is adequate for evaluating and characterizing</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3282.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">toxicity and selecting endpoints for purposes of this risk assessment.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:3310.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Cyprodinil has low acute toxicity via the oral, dermal, and inhalation routes (Toxicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3324.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Category III). Cyprodinil is mildly irritating to the eyes (Toxicity Category III) and negligibly</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3338.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">irritating to the skin (Toxicity Category IV).  It is a dermal sensitizer.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:3366.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">The major target organs of cyprodinil are the liver in both rats and mice and the kidney in</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3380.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">rats.  Liver effects observed consistently in subchronic and chronic studies in rats and mice</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3394.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">include increased liver weights, increases in serum clinical chemistry parameters associated with</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3408.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">adverse effects on liver function, hepatocyte hypertrophy, and hepatocellular necrosis.  Adverse</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3422.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">kidney effects include tubular lesions and inflamation following subchronic exposure of male</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3436.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">rats.  The hematopoietic system also appeared to be a target of cyprodinil, causing mild anemia</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3450.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">in rats exposed subchronically.  Chronic effects in dogs were limited to decreased body-weight</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3464.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">gain, decreased food consumption and decreased food efficiency.  There was no evidence of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3478.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">increased susceptibility in the developmental rat or rabbit study following in utero exposure or in</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3492.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">the two-generation reproduction study following pre- or post-natal exposure.  There was no</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3506.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">evidence of neuropathological or other neurological effects in the available subchronic</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3520.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">neurotoxicity study.  The results of a preliminary immunotoxicity study provided no evidence for</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3534.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">immunotoxicity.  There was no evidence of carcinogenic potential in either the rat chronic</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3548.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">toxicity/carcinogenicity or mouse carcinogenicity studies.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:3576.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">An acute neurotoxicity study (870.6200a) is required in accordance with the revised 40</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3590.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">CFR Part 158 Toxicology Data Requirements.  The available preliminary immunotoxicity study</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3604.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">is considered Upgradeable/Guideline.   The registrant needs to either submit the required Natural</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3618.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Killer cell activity assay or provide justification for why it is not needed.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3646.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Dose Response Assessment</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:3674.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Toxicological points of departure (PODs) were selected for dietary and drinking water</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3688.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">exposure scenarios.  A POD for acute dietary exposure was selected for the population subgroup</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3702.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">females 13-49 years old based on a developmental toxicity study in rabbits.  No acute endpoint</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3716.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">was identified for the remaining population subgroups.  The POD for chronic dietary exposure</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3730.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">was selected from a chronic/carcinogenicity feeding study in rats.  An uncertainty factor of 100x</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3744.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">was applied to PODs for both acute and chronic dietary exposure (10x for interspecies</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3757.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">extrapolation, 10x for intraspecies variation).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:3828.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Exposure/Risk Assessment and Risk Characterization</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:3960.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:275.90pt;top:4666.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 6 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:4032.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Risk assessments were conducted for dietary (food and water) based on registered uses</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4046.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">and requests for reduced PHI and increased tolerance for use of cyprodinil on pome fruit.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4060.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Conservative acute chronic dietary and drinking water risk assessments for cyprodinil conclude</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4074.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">that dietary and drinking water exposure estimates are below HED’s level of concern for the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4088.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">general population and all population subgroups.  The proposed uses do not involve residential</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4102.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">exposure and previous assessments of worker exposure to liquid formulations applied at higher</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4116.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">application rates than those proposed show no risks of concern (D362494, M. Dow, 8/4/09).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4130.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Therefore new occupational and residential risk assessments are not required for this action.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4144.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Aggregate risks from dietary and post-application residential exposures are not of concern.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4172.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Use of Human Studies</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:4200.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">This risk assessment is limited to dietary and drinking water exposures and does not rely</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4214.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">on data from studies in which adult human subjects were intentionally exposed to a pesticide or</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4228.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">other chemical.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4256.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Environmental Justice</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:4284.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Potential areas of environmental justice concerns, to the extent possible, were considered</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4298.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">in this human health risk assessment, in accordance with U.S. Executive Order 12898, "Federal</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4312.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Actions to Address Environmental Justice in Minority Populations and Low-Income</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4326.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Populations," </FONT></FONT><u><FONT COLOR="0000ff"><FONT STYLE="font-size: 12.00pt"><a href="http://www.eh.doe.gov/oepa/guidance/justice/eo12898.pdf">http://www.eh.doe.gov/oepa/guidance/justice/eo12898.pdf</a></FONT></FONT></u><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:4354.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">As a part of every pesticide risk assessment, OPP considers a large variety of consumer</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4368.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">subgroups according to well-established procedures.  In line with OPP policy, HED estimates</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4382.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">risks to population subgroups from pesticide exposures that are based on patterns of that</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4396.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">subgroup’s food and water consumption, and activities in and around the home that involve</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4410.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">pesticide use in a residential setting.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:257.90pt;top:4410.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Whenever appropriate, non-dietary exposures based on</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4424.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">home use of pesticide products and associated risks for adult applicators and for toddlers, youths,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4438.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">and adults entering or playing on treated areas postapplication are evaluated.  Further</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4452.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">considerations are currently in development, as OPP has committed resources and expertise to</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4466.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">the development of specialized software and models that consider exposure to bystanders and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4480.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">farm workers as well as lifestyle and traditional dietary patterns among specific subgroups.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4508.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Regulatory Recommendation</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:4536.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Provided the petitioner submits a revised Section F, HED recommends in favor of the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4550.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">request to amend the registration of Vangard™ Fungicide (EPA Reg. No. 100-828) to reduce the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4564.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">preharvest interval (PHI) on pome fruit from 72- to 0-days as well as the request to amend the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4578.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">registration of Inspire Super</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:209.20pt;top:4576.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">™</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:220.00pt;top:4578.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Fungicide (EPA Reg. No. 100-1317) to increase the maximum use</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4592.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">rate of cyprodinil on pome fruit from 0.04 lb ai/A/application (0.16 lb ai/A/season of cyprodinil</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4606.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">from Inspire Super™) to 0.20 lb ai/A/application (1.0 lb ai/A/season of cyprodinil from Inspire</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4620.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Super™) and reduce the PHI from 86- to 14-days.  Furthermore, HED recommends increasing</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4634.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">the permanent tolerances for residues of cyprodinil in/on pome fruit from 0.1 ppm to 1.7 ppm</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:4752.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:275.90pt;top:5458.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 7 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4824.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">and in apple wet pomace from 0.15 ppm to 4.6 ppm.  Tolerances should be revised, as needed, to</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4838.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">reflect the correct commodity definitions as specified in the Chemistry Summary Document</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4852.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">(D378920, 10/27/10).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:4880.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Based on the proposed amended uses of cyprodinil on pome fruit, the currently</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4894.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">established 0.02 ppm tolerance levels for meat byproducts of cattle, goats, horses, and sheep are</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4908.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">adequate but the currently established tolerance expression for livestock commodities should be</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4922.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">changed to reflect measurement of both parent and metabolite CGA-304075.  Separate tolerances</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4936.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">should be established under 40 CFR §180.532(a) for residues of cyprodinil and CGA-304075</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4950.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">(free and conjugated), expressed in parent equivalents, on meat byproducts of cattle, goats,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4964.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">horses, and sheep at 0.02 ppm (LOQ).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:4992.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">2.0</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:107.95pt;top:4992.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">INGREDIENT PROFILE</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5020.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">2.1</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:5020.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Registered Products</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:5048.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">There are currently 5 active Section 3 cyprodinil registrations in the OPPIN data base.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:76.70pt;top:5077.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">Table 1. Registered Cyprodinil Products</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:5075pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:5075pt;width:475pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:5075pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:5076pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:5076pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:92.10pt;top:5090.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt"><a href="javascript:sortUpdate(document.sort,'8')">Reg #</a></FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:227.05pt;top:5090.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt"><a href="javascript:sortUpdate(document.sort,'2')">Name</a></FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:351.85pt;top:5090.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt"><a href="javascript:sortUpdate(document.sort,'6')">% </a></FONT></FONT><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">ai</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:426.95pt;top:5090.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt"><a href="javascript:sortUpdate(document.sort,'5')">Company Name</a></FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:5089pt;width:271pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:342pt;top:5089pt;width:41pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:383pt;top:5089pt;width:162pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:5089pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:139pt;top:5089pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:341pt;top:5089pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:383pt;top:5089pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:5089pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:76.70pt;top:5103.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">100-811 Cyprodinil Technical</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:367.60pt;top:5103.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">99</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:5102pt;width:271pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:342pt;top:5102pt;width:41pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:383pt;top:5102pt;width:162pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:5103pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:139pt;top:5103pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:341pt;top:5103pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:383pt;top:5103pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:5103pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:76.70pt;top:5116.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">100-828</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.85pt;top:5116.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">Vangard WG Fungicide</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:367.60pt;top:5116.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">75</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:5115pt;width:271pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:342pt;top:5115pt;width:41pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:383pt;top:5115pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:5115pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:5116pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:139pt;top:5116pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:341pt;top:5116pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:383pt;top:5116pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:5116pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:76.70pt;top:5129.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">100-953</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.85pt;top:5129.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">Switch 62.5 WG</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:359.35pt;top:5129.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">37.5</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:5129pt;width:271pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:342pt;top:5129pt;width:41pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:383pt;top:5129pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:5129pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:5129pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:139pt;top:5129pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:341pt;top:5129pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:383pt;top:5129pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:5129pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:76.70pt;top:5143.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">100-1317 Inspire Super</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:359.30pt;top:5143.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">24.1</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:5142pt;width:271pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:342pt;top:5142pt;width:41pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:383pt;top:5142pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:5142pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:5142pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:139pt;top:5142pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:341pt;top:5142pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:383pt;top:5142pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:5142pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:76.70pt;top:5156.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">100-RGEI Palladium (Fungicide)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:359.35pt;top:5156.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">37.5</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:396.90pt;top:5129.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">Syngenta Crop Protection, Inc.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:5155pt;width:271pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:342pt;top:5155pt;width:41pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:383pt;top:5155pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:5155pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:5155pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:5168pt;width:68pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:139pt;top:5155pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:139pt;top:5168pt;width:202pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:341pt;top:5155pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:342pt;top:5168pt;width:41pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:383pt;top:5155pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:384pt;top:5168pt;width:161pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:5155pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:5168pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5183.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">2.2</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:5183.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Registered and Proposed New Uses</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:5211.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Cyprodinil is a systemic anilino-pyrimidine fungicide registered to Syngenta Crop</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5225.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Protection in the United States for use on a wide variety of fruit, nut, herb and vegetable crops</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5239.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">for the control of various plant diseases.  It is formulated as a 75% water-dispersible granule</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5253.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">(WDG), a 62.5% WDG multiple active ingredient (MAI) product containing 37.5% cyprodinil</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5267.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">and 25% fludioxonil, and as a 67.5% oil emulsion in water (EW) MAI containing 24.1% lb/gal</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5281.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">cyprodinil and 8.4% of difenoconazole.  The current application proposes amending existing</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5295.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">registrations for two products.  Use of Vangard™ Fungicide on pome fruit would be amended to</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5309.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">reduce the PHI from 72- to 0-days.  Use of Inspire Super</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:346.70pt;top:5307.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">™</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:357.55pt;top:5309.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Fungicide on pome fruit would be</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5323.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">amended to increase the maximum use rate of cyprodinil from 0.04 lb ai/A/application (0.16 lb</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5337.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">ai/A/season of cyprodinil from Inspire Super™) to 0.20 lb ai/A/application (1.0 lb ai/A/season of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5351.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">cyprodinil from Inspire Super™) and reduce the PHI from 86- to 14-days.  In addition, the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5365.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">petitioner, Syngenta Crop Protection, Inc. proposes to amend the tolerance in 40 CFR §180.532</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5379.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">for residues of the fungicide cyprodinil (2-pyrimidinamine, 4-cyclopropyl-6-methyl-N-phenyl)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5393.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">in or on fruit, pome, group 11 from 0.1 ppm to 1.7 ppm.  Maximum rates based on a review of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5407.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">active and proposed labels are provided in Table 2.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:5544.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:73.50pt;top:5618.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 2.  Maximum Application Rates for Cyprodinil Existing and Proposed New Uses</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:5616pt;width:468pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:539pt;top:5616pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:179.60pt;top:5632.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Application Site</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:364.25pt;top:5632.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Max % AI</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:422.05pt;top:5632.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Max Single AR</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:498.30pt;top:5632.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Reg No.</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:5630pt;width:282pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:356pt;top:5630pt;width:62pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:419pt;top:5630pt;width:71pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:491pt;top:5630pt;width:48pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:73.50pt;top:5646.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">root, leafy, and fruiting vegetables, legumes, citrus, pome, and stone</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:73.50pt;top:5657.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">fruits, berries, nuts, herbs.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:382.00pt;top:5651.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">75</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:432.00pt;top:5651.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">1.3  lb/ai A</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:5644pt;width:282pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:356pt;top:5644pt;width:62pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:419pt;top:5644pt;width:71pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:491pt;top:5644pt;width:48pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:73.50pt;top:5672.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">canola grown in Canada</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:378.25pt;top:5671.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">62.5</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:430.80pt;top:5671.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.33 lb/ai A</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:498.65pt;top:5658.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">100-828</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:5669pt;width:282pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:356pt;top:5669pt;width:62pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:419pt;top:5669pt;width:71pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5699.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">2.3</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:5699.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Structure, Nomenclature, and Physical/Chemical Properties</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:5727.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">The nomenclature and physicochemical properties of cyprodinil are provided in Tables 3</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5740.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">and 4.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5769.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 3. Cyprodinil Nomenclature.</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:67pt;top:5765pt;width:475pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:543pt;top:5765pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5783.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Chemical structure</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:245.95pt;top:5817.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.23pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:258.35pt;top:5796.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.23pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:258.60pt;top:5839.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.23pt">CH</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:268.55pt;top:5843.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 4.77pt">3</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:233.45pt;top:5796.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.23pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:233.70pt;top:5790.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.23pt">H</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:190pt;top:5780pt;width: 1pt;height: 2pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:190pt;top:5783pt;width: 1pt;height:68pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5854.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Common name</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:194.60pt;top:5854.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Cyprodinil</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:68pt;top:5851pt;width:121pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:190pt;top:5851pt;width: 1pt;height: 2pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:191pt;top:5851pt;width:351pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:190pt;top:5853pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5868.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Company experimental name</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:194.50pt;top:5868.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">CGA219417</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:68pt;top:5865pt;width:121pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:190pt;top:5865pt;width: 1pt;height: 2pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:191pt;top:5865pt;width:351pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:190pt;top:5867pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5881.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">IUPAC name</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:194.60pt;top:5881.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">(4-cyclopropyl-6-methyl -pyrimidin-2-yl)-phenyl-amine</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:68pt;top:5879pt;width:121pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:190pt;top:5879pt;width: 1pt;height: 2pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:191pt;top:5879pt;width:351pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:190pt;top:5881pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5895.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">CAS name</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:194.55pt;top:5895.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">2-pyrimidinamine, 4-cyclopropyl-6-methyl-N-phenyl-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:190pt;top:5892pt;width: 1pt;height: 2pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:190pt;top:5895pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5909.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">CAS registry number</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:194.55pt;top:5909.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">121552-61-2</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:68pt;top:5906pt;width:121pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:190pt;top:5906pt;width: 1pt;height: 2pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:191pt;top:5906pt;width:351pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:190pt;top:5908pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5923.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Molecular weight</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:194.50pt;top:5923.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">225.29</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:68pt;top:5920pt;width:121pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:190pt;top:5920pt;width: 1pt;height: 2pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:191pt;top:5920pt;width:351pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:190pt;top:5922pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5936.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">End-use products (EP)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:194.60pt;top:5936.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">75% water-dispersible granule (WDG) formulation (Vangard™ Fungicide; EPA Reg. No. 100-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:194.50pt;top:5947.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">828); a multiple active ingredient (MAI) end-use product (Inspire Super</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:455.90pt;top:5946.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">™</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:464.00pt;top:5947.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Fungicide; EPA</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:194.50pt;top:5957.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Reg. No. 100-1317) formulated as an emulsion [oil] in water (EW), containing 8.4%</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:194.50pt;top:5968.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">difenoconazole and 24.1% cyprodinil</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:68pt;top:5933pt;width:121pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:190pt;top:5933pt;width: 1pt;height: 2pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:191pt;top:5933pt;width:351pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:67pt;top:5981pt;width:122pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:190pt;top:5936pt;width: 1pt;height:44pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:190pt;top:5981pt;width:352pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:5996.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 4. Physicochemical Properties of Technical Grade of Cyprodinil.</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:66pt;top:5995pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:66pt;top:5995pt;width:479pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:5995pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:66pt;top:5996pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:5996pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6008.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Parameter Value Reference</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:66pt;top:6007pt;width:479pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:66pt;top:6008pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:242pt;top:6008pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:422pt;top:6008pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6008pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6019.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Melting point/range</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:248.30pt;top:6019.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">75.9 C</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:66pt;top:6018pt;width:479pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:66pt;top:6019pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:242pt;top:6019pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:422pt;top:6019pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6019pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6030.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">pH</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:248.35pt;top:6030.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">9.5 at 25 C (1% aqueous dispersion)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:66pt;top:6029pt;width:356pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6029pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:66pt;top:6030pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:242pt;top:6030pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:422pt;top:6030pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6030pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6041.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Density</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:248.35pt;top:6041.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">1.21 g/cm at 20 C</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:284.40pt;top:6040.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">3</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6040pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:66pt;top:6041pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:242pt;top:6041pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:422pt;top:6041pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6041pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6052.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Water solubility (mg/L at 25 C)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:248.35pt;top:6052.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">16 at pH 7.6, 20 at pH 5, 13 at pH 7, 5 at pH 9</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:66pt;top:6051pt;width:356pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6051pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:66pt;top:6052pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:242pt;top:6052pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:422pt;top:6052pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6052pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6063.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Solvent solubility (g/L at 25 C)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:248.35pt;top:6063.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">ethanol-160, acetone-610, toluene-460,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:248.35pt;top:6074.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">n-octanol-160, n-hexane-30</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:66pt;top:6063pt;width:356pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6063pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:66pt;top:6063pt;width: 1pt;height:21pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:242pt;top:6063pt;width: 1pt;height:21pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:422pt;top:6063pt;width: 1pt;height:21pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6063pt;width: 1pt;height:21pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6085.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Vapor pressure</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:248.35pt;top:6085.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">3.8 x 10</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:277.70pt;top:6084.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">-6</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:284.90pt;top:6085.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">mm Hg at 25 C</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6084pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:66pt;top:6085pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:242pt;top:6085pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:422pt;top:6085pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6085pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6096.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Dissociation constant, pK</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:164.95pt;top:6100.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">a</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:248.35pt;top:6096.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">4.44 at 20 C</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:66pt;top:6095pt;width:356pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6095pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:66pt;top:6096pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:242pt;top:6096pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:422pt;top:6096pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6096pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6107.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Octanol/water partition coefficient,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6118.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Log(K</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:96.00pt;top:6122.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">OW</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:106.00pt;top:6118.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">) at 25 C</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:248.35pt;top:6107.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">3.9 at pH 5, 4.0 at pH 7,  4.0 at pH 9</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6106pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:66pt;top:6107pt;width: 1pt;height:21pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:242pt;top:6107pt;width: 1pt;height:21pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:422pt;top:6107pt;width: 1pt;height:21pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6107pt;width: 1pt;height:21pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6129.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">UV/visible absorption spectrum</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6139.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">(molar absorption coefficients for the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6150.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">absorbance maximum)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:248.35pt;top:6129.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">29,200 L/mol·cm at 270.8 nm (neutral)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:248.35pt;top:6139.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">29,200 L/mol·cm at 251.6 nm (acidic)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:248.35pt;top:6150.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">29,200 L/mol·cm at 316.8 nm (acidic)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:248.35pt;top:6160.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">28,400 L/mol·cm at 270.8 nm (basic)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:437.35pt;top:6084.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">DP# 345970, W. Cutchin,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:472.70pt;top:6095.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">6/4/08</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6128pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:66pt;top:6128pt;width: 1pt;height:42pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:66pt;top:6171pt;width:176pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:242pt;top:6128pt;width: 1pt;height:42pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:243pt;top:6171pt;width:179pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:422pt;top:6128pt;width: 1pt;height:42pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:423pt;top:6171pt;width:121pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6128pt;width: 1pt;height:42pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:545pt;top:6171pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:275.90pt;top:6250.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 8 of 38</FONT></FONT></FONT></SPAN>
<span style="color:#000000;background-color:#ffffff;position:absolute;left:0.00pt;top:5544.00pt;z-index:-1;"><img style="width:612pt;height:792pt;" src="outputfile-892646128.htm_files\outputfile-892646128_background7.png"></span>
<SPAN STYLE="position:absolute;left:71.76pt;top:6336.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:275.90pt;top:7042.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 9 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6408.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.0       HAZARD CHARACTERIZATION/ASSESSMENT</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6434.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.1</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:6434.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Hazard Characterization</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:6462.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">The toxicology database for cyprodinil is adequate for evaluating and characterizing</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6476.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">cyprodinil toxicity and selecting endpoints for purposes of this risk assessment.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:6504.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Cyprodinil has low acute toxicity via the oral, dermal, and inhalation routes (Toxicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6518.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Category III).  Cyprodinil is mildly irritating to the eyes (Toxicity Category III) and negligibly</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6532.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">irritating to the skin (Toxicity Category IV).  It is a dermal sensitizer.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:6560.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">The major target organs of cyprodinil are the liver and the kidney.  Liver effects were</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6574.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">consistent among male and female rats and mice in both subchronic and chronic studies and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6588.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">typically included increased liver weights along with increases in serum clinical chemistry</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6602.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">parameters associated with adverse effects on liver function (i.e., increased cholesterol and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6616.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">phospholipid levels).  Microscopic lesions in rats and mice included hepatocyte hypertrophy and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6630.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">hepatocellular necrosis.  In the kidneys, adverse effects were manifested as chronic tubular</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6644.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">lesions and chronic kidney inflamation following subchronic exposure of male rats.  Chronically,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6658.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">cyprodinil caused increased kidney weights and progressive nephropathy in male rats.  Chronic</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6672.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">effects in dogs were limited to decreased body-weight gain, decreased food consumption and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6686.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">decreased food efficiency; liver toxicity was not seen in the dog.  The hematopoietic system also</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6700.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">appeared to be a target of cyprodinil, causing mild anemia in rats exposed subchronically</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6714.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">(reductions in hematocrit and hemoglobin and microcytosis).  Although increases in thyroid</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6728.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">weight and/or hypertrophy of thyroid follicular cells were observed at higher doses in the rat 28-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6742.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">day oral-toxicity studies (both feeding and oral gavage) and in the 90-day oral-toxicity study in</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6756.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">rats, treatment-related changes in thyroid weights or gross/microscopic observations were not</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6769.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">observed in the chronic rat study or in other studies (thyroid hormones were not evaluated in any</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6783.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">study).  A preliminary subchronic immunotoxicity in mice showed no treatment-related effects</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6797.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">on absolute, adjusted, or relative spleen or thymus weights; no effects on specific activity or total</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6811.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">activity of splenic IgM antibody-forming cells to the T cell-dependent antigen sRBC.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:6839.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">A subchronic neurotoxicity study showed no treatment related effects on mortality,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6853.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">clinical signs, or gross or histological neuropathology.  FOB and motor activity testing revealed</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6867.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">no treatment related effects up to the highest dose tested.  No clinical signs suggestive of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6881.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">neurobehavioral alterations or evidence of neuropathological effects were observed in the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6895.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">available oral-toxicity studies.  There was also no evidence of a neurodevelopmental effect in the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6909.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">rat or rabbit developmental-toxicity studies or in the rat two-generation reproductive-toxicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6923.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">study.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:6951.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Based on pharmacokinetic/metabolism studies in the rat biphasic first order kinetics were</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6965.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">noted for absorption and excretion of cyprodinil, with durations of 0.3-1.2 hours for the first</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6979.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">phase, and 27-65 hours for the second phase.  Excretion was rapid and almost complete, with</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:6993.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">urine as the principal route of excretion (48-68%), and >90% of the administered dose detected</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7007.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">in the urine and feces within 48 hours.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:7128.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:7834.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 10 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:7214.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">There was no evidence of increased susceptibility in the developmental rat or rabbit study</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7228.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">following in utero exposure or in the two-generation reproduction study following pre- and post-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7242.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">natal exposure.  Fetal toxicity, manifested as significantly lower fetal weights and an increased</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7256.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">incidence of delayed ossification in the rat and a slight increase in litters showing extra ribs</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7270.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">(13 ) in the rabbit, was reported in developmental toxicity studies.  In a rat two-generation</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:88.00pt;top:7268.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">th</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7284.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">reproduction study, significantly lower pup weights for F and F offspring were observed.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:347.00pt;top:7289.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">1</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:381.00pt;top:7289.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">2</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7298.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">However, each of these fetal/neonatal effects occurred at the same dose levels at which maternal</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7312.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">toxicity (decreased body weight gain) was observed and were considered to be secondary to</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7326.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">maternal toxicity.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:7354.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">An acute neurotoxicity study (870.6200a) is required in accordance with the revised 40</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7368.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">CFR Part 158 Toxicology Data Requirements.  The available preliminary immunotoxicity study</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7382.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">is considered Upgradeable/Guideline due to the omission of a NK cell activity assay.  The</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7396.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">registrant needs to either submit the NK assay or provide justification for why it is not needed.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:7424.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">The complete toxicity profile for cyprodinil is provided in Appendix 1.2, Tables 2 and 3.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7452.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.2</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:7452.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">FQPA Hazard Considerations</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:7480.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">The toxicity database for cyprodinil is sufficient for a full hazard evaluation and is</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7494.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">considered adequate to evaluate risks to infants and children.  Acceptable developmental toxicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7508.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">studies in the rat and rabbit, acceptable multi- and single generation reproduction studies in the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7522.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">rat, and an acceptable subchronic neurotoxicity study in the rat have been submitted.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:7550.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.2.1</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:7550.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Neurotoxicity</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:7578.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">In a subchronic neurotoxicity study (MRID 45906101) cyprodinil technical (99.2%) was</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7592.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">administered to 10 /Tif: RAIf Sprague-Dawley albino rats/sex/group at doses of 0, 80, 800, or</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7606.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">8000 ppm (equivalent to 0, 5.8, 54.5 and 601 mg/kg/day in males and 0, 6.3, 58.7, and 631</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7620.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">mg/kg/day in females).  There were no treatment related effects on mortality, clinical signs, or</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7634.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">gross or histologic neuropathology.  Functional Observational Battery (FOB) and motor activity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7648.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">testing revealed no treatment related effects up to the highest dose tested.  Based on the results of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7662.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">this study, the neurotoxicity LOAEL for male and female rats was not identified.  The</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7676.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">neurotoxicity NOAEL is </FONT></FONT><FONT COLOR="000000"><u><FONT STYLE="font-size: 12.00pt">> </FONT></u><FONT STYLE="font-size: 12.00pt">8000 (601 mg/kg/day in males, 631 mg/kg/day in females.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:7704.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.2.2</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:153.00pt;top:7704.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Developmental Toxicity</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:7732.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.2.2.1    Rat Developmental Study</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:7760.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">In a developmental toxicity study (MRID 43709033), cyprodinil technical (99.5%) was</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7774.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">administered in 3% aqueous corn starch suspension by oral gavage to 20-23 Tif:RAIf(SPF)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7788.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">females albino rats per dose of 0, 20, 200 or 1000 mg/kg/day or gestation days 6-15.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7802.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Treatment related findings included reduced locomotor activity (one high dose female),</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:7920.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:8626.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 11 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:7992.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">significantly lower mean body weight (16%), body weight gain (65%), gravid uterine weight</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8006.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">(18%), and mean carcass weight (10%), and significantly decreased food consumption (32-42%)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8020.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">in high-dose females.  The LOAEL for maternal toxicity is 1000 mg/kg/day based on lower body</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8034.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">weight/body weight gain and reduced food consumption. The NOAEL was 200 mg/kg/day.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:8062.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">There were significantly lower mean fetal weights (11%) in the high-dose group</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8076.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">compared to controls as well as a significant increase in skeletal anomalies in the high-dose</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8090.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">group relative to the control, which was due to abnormal ossification (4/20 litters in the high</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8104.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">dose group compared to 0 in any other group), primarily as absent or reduced metacarpal 5</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8118.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">ossification.  The skeletal anomalies/variations were considered to be a transient developmental</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8132.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">delay that occurs secondary to the maternal toxicity noted in the high-dose group. The LOAEL</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8146.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">for developmental toxicity is 1000 mg/kg/day based on lower mean fetal weights and an</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8160.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">increased incidence of delayed ossification.  The NOAEL for developmental toxicity is 200</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8174.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">mg/kg/day.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:8202.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.2.2.2 Rabbit Developmental Study</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:8232.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">In a developmental toxicity study (MRID 43709032), cyprodinil technical (99.5%) was</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8246.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">administered in 3% aqueous corn starch suspension to 19 inseminated female rabbits (Russian</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8260.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Chbb:HM, SPF)/dose by gavage at dose levels of 0, 5, 30, 150, or 400 mg/kg/day from days 7</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8274.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">through 19 of gestation. Mean maternal body weight gain (p <0.01) and food consumption (not</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8288.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">significant) decreased, mainly during the first week of treatment in the 400 mg/kg/day group.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8302.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Mean body weight gain was 622% less than controls (p <0.01) in this group between days 7 and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8316.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">13 of gestation. The maternal LOAEL is 400 mg/kg/day, based on decreased body weight gain.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8330.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">The maternal NOAEL is 150 mg/kg/day.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:8358.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Fetuses at the 400 mg/kg/day dose exhibited indications of an increased incidence of a</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8372.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">13th rib (not significant). Although there were indications of developmental delays in fetal</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8386.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">skeletons, such as poor or absent ossification of the sternebrae and metacarpals at all dose levels,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8400.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">only the extra rib is likely to be compound related. Uni- or bilateral hyperflexion of the carpal</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8414.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">joint at the 400 and 150 mg/kg/day doses (not significant) was not associated with the skeletal</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8428.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">changes. The fetal developmental LOAEL is 400 mg/kg/day based on a slight increase of litters</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8442.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">showing extra (13th) ribs. The fetal developmental NOAEL is 150 mg/kg/day.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:8470.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.2.3  Reproductive Toxicity</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:8496.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">In a two-generation reproduction study (MRID No. 43709034), Tif:RAIf rats (30</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8510.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">rats/sex/dose), with one litter per generation received cyprodinil (99.5 %) in the diet at doses of,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8524.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">10, 100, 1000 or 4000 ppm (actual intake, males: 0, 0.7, 6.7, 68 or 273; females: 0, 0.8, 8.2, 81 or</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8538.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">326 mg/kg/day) for a 10 week pre-mating period.  Signs of toxicity at 4000 ppm consisted of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8552.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">lower body weights (12.5%) in the F0 females after the pre-mating period. Increased liver weight</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8566.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">in 1000 (marginal) and 4000 ppm males and females was not supported by histopathological</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8580.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">findings.  Although these were considered treatment related, they were considered to be non-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8594.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">adverse.  The LOAEL for maternal systemic toxicity is 4000 ppm (about 326 mg/kg/day) based</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:8712.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:9418.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 12 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8784.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">on lower body weights in the F0 females during the pre-mating period. The NOAEL for maternal</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8798.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">systemic toxicity was 1000 ppm (about 81 mg/kg/day).  Reviewers determined that pre-mating</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8812.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">body weight gain (not absolute body weight) should be used as the basis of the NOAEL.  Signs</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8826.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">of fetal effects included significantly lower F1 and F2 pup weights in the high-dose group during</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8840.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">lactation, which continued to be lower than controls post-weaning and after the pre-mating</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8854.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">period (examination in F1 generation only).  The LOAEL for reproductive/developmental</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8868.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">toxicity is 4000 ppm (about 326 mg/kg/day) based on decreased pup weights (F1 and F2).  The</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8882.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">NOAEL for reproductive toxicity is 1000 ppm (about 81 mg/kg/day).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:8910.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.2.4</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.05pt;top:8910.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Pre-and/or Postnatal Toxicity</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:8938.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">The database is considered adequate for selection of study endpoints and determination</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8952.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">of a dose/response to characterize the potential prenatal or postnatal toxicity of cyprodinil to</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8966.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">infants and children.  No increase in susceptibility was seen in developmental toxicity studies in</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8980.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">rat and rabbit or reproductive toxicity studies in the rat.  Toxicity to offspring was observed at</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:8994.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">dose levels the same or greater than those causing maternal or parental toxicity.  Based on the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9008.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">results of developmental and reproductive toxicity studies, there is not a concern for increased</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9022.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">qualitative and/or quantitative susceptibility following in utero exposure to cyprodinil.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:9050.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">A developmental neurotoxicity study is not required.   Based on available data there is no</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9064.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">evidence of neurotoxic potential for cyprodinil.  Neurotoxicity was not observed in subchronic</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9078.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">neurotoxicity study or the prenatal developmental toxicity studies in rats and rabbits.  Although</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9092.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">an acute neurotoxicity study is not available, the NOAEL from an acute study is unlikely to be</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9106.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">appreciably lower than the NOAEL of 600 mg/kg/day from the subchronic neurotoxicity study.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:9134.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.2.5 FQPA Factor</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:9162.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Since there are adequate developmental studies in rats and rabbits and an adequate multi-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9176.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">generation study in rats, no residual uncertainties that indicate the need for a factor, and no</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9190.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">evidence of neurotoxicity based on available data, the FQPA factor has been reduced to 1X.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9218.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.3</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:9218.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Toxicity Endpoint Selection</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:9246.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.3.1</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:9246.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Acute Reference Dose (aRfD) – Females 13-49</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:9274.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><u><FONT STYLE="font-size: 12.00pt">Selected Study</FONT></u><FONT STYLE="font-size: 12.00pt">: Developmental toxicity in the rabbit; MRID 43709032. See Section 3.2.1</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:9302.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><u><FONT STYLE="font-size: 12.00pt">Dose and Endpoint for Establishing a POD</FONT></u><FONT STYLE="font-size: 12.00pt">:  NOAEL = 150 mg/kg/day day based</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9316.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">developmental LOAEL of 400 mg/kg/day was based on a slight increase in the incidence of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9330.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">litters showing extra (13 ) ribs, which is presumed to occur after a single exposure.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:189.25pt;top:9328.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">th</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:9358.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><u><FONT STYLE="font-size: 12.00pt">Uncertainty Factor (UF)</FONT></u><FONT STYLE="font-size: 12.00pt">: 100x (10x for interspecies variation and 10x for intraspecies</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9372.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">variation)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:9504.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:10210.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 13 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:187.40pt;top:9582.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">Acute RfD =     </FONT></FONT><u><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">150 mg/kg (NOAEL) </FONT></FONT></u><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">=     1.5 mg/kg</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:292.90pt;top:9595.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">100 (UF)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:90pt;top:9576pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:90pt;top:9576pt;width:431pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:520pt;top:9576pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:90pt;top:9576pt;width: 1pt;height:33pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:90pt;top:9609pt;width:430pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:520pt;top:9576pt;width: 1pt;height:33pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:520pt;top:9609pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:9625.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.3.2</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:9625.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Acute Reference Dose (aRfD) – General Population</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:9652.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">For the general population, no effects that could be attributed to a single exposure were</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9666.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">observed in the oral-toxicity studies, including the developmental toxicity studies in rats and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9680.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">rabbits. Therefore, an acute RfD was not established for this population subgroup.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:9709.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.3.3  Chronic Reference Dose (cRfD) - All Populations</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:9736.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Selected Study: Combined Chronic Toxicity/Carcinogenicity-Rat;  MRID  43737602,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9750.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">44429401 and 44417902</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9778.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">In a 24-month chronic toxicity/oncogenicity study  Tif:RAIf rats (50 rats/sex/dose -</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9792.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">carcinogenicity portion, plus 20/sex/dose laboratory investigations) were fed diets containing 0,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9806.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">5, 75, 1000 or 2000 ppm (M - 0.177, 2.7, 35.6 or 73.6 mg/kg/day; F - 0.204,3.22,41.2 or 87.1</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9820.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">mg/kg/day) cyprodinil (99.2-99.6%).  An additional 10/sex/dose were fed test diets for 12</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9834.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">months (interim sacrifice).  Survival was slightly lower in males at 2000 ppm relative to control</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9848.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">and other dose groups.  Toxicologically significant findings included increased liver weights in</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9862.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">high-dose males (10.7%) and a dose-related increase in the incidence of spongiosis hepatis in the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9876.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">liver of 1000 and 2000 ppm males (5, 5, 3, 17 and 23 %, controls to high dose). For chronic</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9890.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">toxicity, the NOAEL was 75 ppm (2.7 mg/kg/day) and the LOAEL was 1000 ppm (35.6</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9904.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">mg/kg/day) based on degenerative liver lesions (spongiosis hepatis) in males.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:9932.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><u><FONT STYLE="font-size: 12.00pt">Dose and Endpoint for Establishing a POD</FONT></u><FONT STYLE="font-size: 12.00pt">:  2.7 mg/kg/day (NOAEL) based on the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9946.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">histopathological alterations in the liver (spongiosis hepatis) in males at 35.6 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:9960.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">(LOAEL).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:9988.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><u><FONT STYLE="font-size: 12.00pt">Uncertainty Factor (UF)</FONT></u><FONT STYLE="font-size: 12.00pt">: 100x (10x for interspecies variation and 10x for intraspecies</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10002.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">variation)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:10030.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><u><FONT STYLE="font-size: 12.00pt">Comments about Study/Endpoint</FONT></u><FONT STYLE="font-size: 12.00pt">: The selected NOAEL is the lowest NOAEL observed</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10044.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">in the most sensitive species following long-term exposure.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:177.70pt;top:10078.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">Chronic RfD =     </FONT></FONT><u><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">2.7 mg/kg (NOAEL) </FONT></FONT></u><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">=     0.027 mg/kg</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:292.90pt;top:10091.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">100 (UF)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:90pt;top:10071pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:90pt;top:10071pt;width:431pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:520pt;top:10071pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:90pt;top:10072pt;width: 1pt;height:33pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:90pt;top:10105pt;width:430pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:520pt;top:10072pt;width: 1pt;height:33pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:520pt;top:10105pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;left:71.76pt;top:10296.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:11002.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 14 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:10368.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.3.4</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.05pt;top:10368.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Classification of Carcinogenic Potential</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:10396.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Based on the lack of evidence of carcinogenicity in mice and rats at doses that were</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10410.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">judged to be adequate to assess the carcinogenic potential, cyprodinil was classified as “not</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10424.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">likely to be carcinogenic to humans”, according to EPA Proposed Guidelines for Carcinogen</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10438.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Risk Assessment (July 1999).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10466.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.4</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:10466.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Recommendation for Aggregate Exposure Risk Assessments</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:10494.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">When there are potential residential exposures to the pesticide, aggregate risk assessment</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10508.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">must consider exposures from three major sources: oral, dermal and inhalation exposures.  Since</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10522.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">there are no residential incidental oral exposures to cyprodinil, aggregate exposure from food</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10536.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">and non-food oral exposures is not required.  However, an aggregate risk assessment of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10550.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">combined short-term dermal, inhalation and background dietary exposure is required for</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10564.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">residential handlers because PODs selected for these exposure routes are based on common</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10578.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">toxicological effects (i.e., liver effects).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10606.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.5 Summary of Endpoints Selected for Risk Assessment</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:10634.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Toxicological doses/endpoints selected for the cyprodinil risk assessment are provided in</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10648.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Table 6 and 7.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:10676.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 6. Summary of Toxicological Doses and Endpoints for Cyprodinil  for Use in Dietary Human Health Risk Assessments</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:31pt;top:10675pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:31pt;top:10675pt;width:543pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:10675pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:31pt;top:10676pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:10676pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:10700.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Exposure/Scenario</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:140.35pt;top:10694.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Point of</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:140.35pt;top:10706.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Departure</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:216.85pt;top:10689.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Uncertainty/F</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:216.85pt;top:10700.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">QPA Safety</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:216.85pt;top:10712.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Factors</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.35pt;top:10689.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">RfD, PAD, LOC</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.35pt;top:10700.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">for Risk</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.35pt;top:10712.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Assessment</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.35pt;top:10689.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Study and Toxicological Effects</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:31pt;top:10687pt;width:543pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:31pt;top:10688pt;width: 1pt;height:35pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:134pt;top:10688pt;width: 1pt;height:35pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:211pt;top:10688pt;width: 1pt;height:35pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:10688pt;width: 1pt;height:35pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:377pt;top:10688pt;width: 1pt;height:35pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:10688pt;width: 1pt;height:35pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:10730.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acute Dietary</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:10742.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Females 13-50 years</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:140.35pt;top:10730.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">NOAEL = 150</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:140.35pt;top:10742.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:216.85pt;top:10730.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">UFA= 10x</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:216.85pt;top:10742.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">UFH=10x</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:216.85pt;top:10753.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">FQPA SF= 1x</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.35pt;top:10730.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acute RfD = 1.5</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.35pt;top:10742.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.35pt;top:10753.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">aPAD = 1.5</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.35pt;top:10765.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.35pt;top:10724.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Developmental Toxicity - rabbit</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.35pt;top:10736.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Developmental LOAEL = 400 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.35pt;top:10747.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">based on slight increase of litters showing</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.35pt;top:10759.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">extra ribs (13 ).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:436.50pt;top:10757.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">th</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:31pt;top:10723pt;width:543pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:31pt;top:10724pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:134pt;top:10724pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:211pt;top:10724pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:10724pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:377pt;top:10724pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:10724pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:10809.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Chronic Dietary</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:10820.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(All Populations)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:140.35pt;top:10809.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">NOAEL= 2.7</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:140.35pt;top:10820.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:216.85pt;top:10803.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">UFA= 10x</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:216.85pt;top:10814.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">UFH=10x</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:216.85pt;top:10826.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">FQPA SF= 1x</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.35pt;top:10791.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Chronic RfD =</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.35pt;top:10803.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.027</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.35pt;top:10814.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.35pt;top:10826.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">cPAD =</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.35pt;top:10838.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.027mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.35pt;top:10797.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">2-Year Chronic Toxicity/ Carcinogenicity- rat</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.35pt;top:10809.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 35.6 mg/kg/day based on</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.35pt;top:10820.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">degenerative liver lesions (spongiosis</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.35pt;top:10832.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">hepatitis) in males.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:31pt;top:10790pt;width:543pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:31pt;top:10791pt;width: 1pt;height:57pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:134pt;top:10791pt;width: 1pt;height:57pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:211pt;top:10791pt;width: 1pt;height:57pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:10791pt;width: 1pt;height:57pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:377pt;top:10791pt;width: 1pt;height:57pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:10791pt;width: 1pt;height:57pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:10850.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Cancer (all routes)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:140.35pt;top:10850.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Classification: “Not likely to be carcinogenic to humans”</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:31pt;top:10849pt;width:543pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:31pt;top:10849pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:31pt;top:10861pt;width:103pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:134pt;top:10849pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:135pt;top:10861pt;width:439pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:10849pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:10861pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10862.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and  used to</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10872.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10883.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">NOAEL = no observed adverse effect level.  LOAEL = lowest observed adverse effect level.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10893.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">UF = uncertainty factor.  UF = extrapolation from animal to human (interspecies).  UF = potential variation in sensitivity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:175.50pt;top:10897.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">A</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:388.90pt;top:10897.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">H</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10904.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">among members of the human population (intraspecies).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10914.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">SF = FQPA Safety Factor.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10925.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">PAD = population adjusted dose (a = acute, c = chronic).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10936.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">RfD = reference dose.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10946.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">MOE = margin of exposure.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:10957.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">LOC = level of concern.  N/A = not applicable.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:11088.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:11794.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 15 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:11161.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 7.  Summary of Toxicological Doses and Endpoints for Cyprodinil  for Use in Residential Human Health Risk</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:11172.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Assessments</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:31pt;top:11160pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:31pt;top:11160pt;width:543pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:11160pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:31pt;top:11160pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:11160pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:11190.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Exposure/</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:11202.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Scenario</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:140.45pt;top:11190.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Point of</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:140.45pt;top:11202.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Departure</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:215.00pt;top:11190.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Uncertainty</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:215.00pt;top:11202.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Factors</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.60pt;top:11185.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Level of Concern</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.60pt;top:11196.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">for Risk</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.60pt;top:11208.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Assessment</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.55pt;top:11196.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Study and Toxicological Effects</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:31pt;top:11183pt;width:347pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:378pt;top:11183pt;width:196pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:11183pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:31pt;top:11184pt;width: 1pt;height:35pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:134pt;top:11184pt;width: 1pt;height:35pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:209pt;top:11184pt;width: 1pt;height:35pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:11184pt;width: 1pt;height:35pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:377pt;top:11184pt;width: 1pt;height:35pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:11184pt;width: 1pt;height:35pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:11226.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Dermal  Short-Term</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:11237.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(1-30 days)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:11249.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(dermal absorption</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:11260.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">rate = 30%)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:140.45pt;top:11237.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Oral NOAEL=</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:142.90pt;top:11249.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">62 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:215.00pt;top:11239.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">UF = 10x</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:227.70pt;top:11243.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">A</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:215.00pt;top:11250.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">UF =10x</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:227.70pt;top:11255.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">H</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.60pt;top:11239.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Residential LOC</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.60pt;top:11250.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">for MOE = 100</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.50pt;top:11220.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">28-Day Feeding/Range-finding - rat</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.50pt;top:11232.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 299 mg/kg/day based on decreased</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.50pt;top:11243.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">body-weight gain, increased cholesterol and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.50pt;top:11255.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">phospholipid levels, microcytosis, and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.50pt;top:11266.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">hepatocyte hypertrophy.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:31pt;top:11219pt;width:347pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:378pt;top:11219pt;width:196pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:11219pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:31pt;top:11219pt;width: 1pt;height:60pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:134pt;top:11219pt;width: 1pt;height:60pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:209pt;top:11219pt;width: 1pt;height:60pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:11219pt;width: 1pt;height:60pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:377pt;top:11219pt;width: 1pt;height:60pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:11219pt;width: 1pt;height:60pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:11300.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Inhalation Short- Term</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:11312.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(1-30 days)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:140.45pt;top:11299.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Oral NOAEL=</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:142.90pt;top:11310.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">62 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:215.00pt;top:11300.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">UF = 10x</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:227.70pt;top:11305.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">A</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:215.00pt;top:11312.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">UF =10x</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:227.70pt;top:11316.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">H</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.60pt;top:11300.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Residential LOC</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.60pt;top:11312.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">for MOE = 100</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.50pt;top:11281.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">28-Day Feeding/Range-finding - rat</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.50pt;top:11293.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 299 mg/kg/day based on decreased</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.50pt;top:11304.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">body-weight gain, increased cholesterol and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.50pt;top:11316.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">phospholipid levels, microcytosis, and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:383.50pt;top:11328.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">hepatocyte hypertrophy.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:31pt;top:11280pt;width:347pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:378pt;top:11280pt;width:196pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:11280pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:31pt;top:11281pt;width: 1pt;height:60pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:134pt;top:11281pt;width: 1pt;height:60pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:209pt;top:11281pt;width: 1pt;height:60pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:11281pt;width: 1pt;height:60pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:377pt;top:11281pt;width: 1pt;height:60pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:11281pt;width: 1pt;height:60pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:36.90pt;top:11342.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Cancer (all routes)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:140.50pt;top:11342.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Not likely human carcinogen</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:31pt;top:11342pt;width:347pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:378pt;top:11342pt;width:196pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:11342pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:31pt;top:11342pt;width: 1pt;height:14pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:31pt;top:11355pt;width:103pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:134pt;top:11342pt;width: 1pt;height:14pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:135pt;top:11355pt;width:439pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:11342pt;width: 1pt;height:14pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:574pt;top:11355pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11367.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">3.6 Endocrine Disruption</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:11395.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">As required under FFDCA section 408(p), EPA has developed the Endocrine Disruptor</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11409.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Screening Program (EDSP) to determine whether certain substances (including pesticide active</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11423.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">and other ingredients) may have an effect in humans or wildlife similar to an effect produced by</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11437.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">a “naturally occurring estrogen, or other such endocrine effects as the Administrator may</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11451.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">designate.”  The EDSP employs a two-tiered approach to making the statutorily required</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11465.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">determinations. Tier 1 consists of a battery of 11 screening assays to identify the potential of a</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11479.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">chemical substance to interact with the estrogen, androgen, or thyroid (E, A, or T) hormonal</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11493.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">systems.  Chemicals that go through Tier 1 screening and are found to have the potential to</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11507.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">interact with E, A, or T hormonal systems will proceed to the next stage of the EDSP where EPA</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11521.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">will determine which, if any, of the Tier 2 tests are necessary based on the available data. Tier 2</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11535.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">testing is designed to identify any adverse endocrine related effects caused by the substance, and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11549.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">establish a dose-response relationship between the dose and the E, A, or T effect.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:11577.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Between October 2009 and February 2010, EPA issued test orders/data call-ins for the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11591.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">first group of 67 chemicals, which contains 58 pesticide active ingredients and 9 inert</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11605.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">ingredients.  This list of chemicals was selected based on the potential for human exposure</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11619.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">through pathways such as food and water, residential activity, and certain post-application</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11633.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">agricultural scenarios.  This list should not be construed as a list of known or likely endocrine</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11647.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">disruptors.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:11675.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Cyprodinil is not among the group of 58 pesticide active ingredients on the initial list to</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11689.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">be screened under the EDSP.  Under FFDCA sec. 408(p) the Agency must screen all pesticide</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11703.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">chemicals.  Accordingly, EPA anticipates issuing future EDSP test orders/data call-ins for all</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11717.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">pesticide active ingredients.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11745.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">For further information on the status of the EDSP, the policies and procedures, the list of 67</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11759.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">chemicals, the test guidelines and the Tier 1 screening battery, please visit our website:</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:11880.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:12586.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 16 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11952.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">h</FONT><FONT STYLE="font-size: 12.00pt"><a href="http://www.epa.gov/endo/.">ttp://www.epa.gov/endo/.</a></FONT><FONT STYLE="font-size: 12.00pt"></FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:11980.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.0</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:107.95pt;top:11980.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">DIETARY AND DRINKING WATER EXPOSURE ASSESSMENT</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12008.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:12008.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Residue Chemistry Profile</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:12036.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.1</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.05pt;top:12036.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Metabolism in Primary Crops, Livestock and Rotational Crops</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:12064.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">The nature of the residue in plants is adequately understood based on acceptable</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12078.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">metabolism studies on apple, peach, potato, tomato, and wheat.  These studies indicated that</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12092.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">cyprodinil is metabolized primarily by hydroxylation followed by sugar conjugation.  Cleavage</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12106.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">of the amino bridge, opening of the pyrimidine ring, opening of the cyclopropyl ring and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12120.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">formation of thiolactic acid conjugates are minor pathways.  Incorporation into starch was</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12134.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">observed in potato tubers and wheat grain.  The nature of the residue in ruminants is adequately</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12148.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">understood based on acceptable lactating goat metabolism studies.  ARIA and HED have</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12162.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">concluded that the residues of concern for both risk assessment and the tolerance definition</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12176.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">should include the combined residues of cyprodinil and free and conjugated CGA-304075 (4-[(4-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12190.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">cyclopropyl-6-methylpyrimidin-2-yl)amino]-phenol, expressed in parent equivalents (D345970</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12204.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">and D345182, G. Kramer, 6/4/08).  The nature of the residue in confined rotational crops is</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12218.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">understood (DP# D257898, S. Levy, 2/8/2000).  Adequate confined rotational crop studies</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12232.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">conducted at 2.2x and 1.5x the current maximum use rate for rotated crops (1.3 lb ai/A) are</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12246.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">available.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:12274.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.2</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:12274.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Residues of Concern</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:12302.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Residues of concern for dietary and drinking water risk assessment and tolerance</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12316.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">expression for cyprodinil are provided in Table 8.  HED recommends that the current tolerance</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12330.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">expression for animal commodities be changed to reflect both parent and metabolite CGA-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12344.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">304075 (4-[(4-cyclopropyl-6-methyl-2-2-pyrimidinyl)amino]-phenol).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:74.15pt;top:12373.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 8:  Summary of MARC Decisions for Cyprodinil</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:12371pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:12371pt;width:459pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:12371pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:12372pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:12372pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:284.10pt;top:12385.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Residues of Concern</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:374.15pt;top:12383.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">1</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:12384pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:130pt;top:12384pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:12384pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:86.30pt;top:12391.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Matrix</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:198.05pt;top:12397.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">For Risk Assessment</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:289.20pt;top:12395.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">2</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:390.35pt;top:12397.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">For Tolerance Expression</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:12396pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:12396pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:130pt;top:12396pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:359pt;top:12396pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:12396pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:74.15pt;top:12409.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Plants cyprodinil</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:362.15pt;top:12409.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">cyprodinil</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:12408pt;width:459pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:12408pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:130pt;top:12408pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:359pt;top:12408pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:12408pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:74.15pt;top:12421.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Livestock</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:132.65pt;top:12421.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">cyprodinil and CGA-304075</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:362.15pt;top:12421.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">cyprodinil and CGA-304075</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:12420pt;width:459pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:12420pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:130pt;top:12420pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:359pt;top:12420pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:12420pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:74.15pt;top:12434.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Water</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:132.70pt;top:12434.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">cyprodinil and CGA 249287</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:362.15pt;top:12434.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">cyprodinil</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:12433pt;width:459pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:12433pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:12445pt;width:58pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:130pt;top:12433pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:130pt;top:12445pt;width:229pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:359pt;top:12433pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:360pt;top:12445pt;width:170pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:12433pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:12445pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:12460.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.3   Residue Analytical Methods</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:12489.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.3.1 Enforcement Methods</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:12516.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Adequate HPLC/UV methods with column switching (Syngenta Methods AG-631 and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12530.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">AG-631B) are available for enforcing tolerances of cyprodinil on plant commodities.  The LOQs</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12544.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">for these methods range from 0.01 to 0.05 ppm depending on the plant commodities.  Method</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12558.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">AG-631B also contains procedures for confirmatory analysis by GC/NPD.</FONT></FONT></FONT></SPAN>
<span style="color:#000000;background-color:#ffffff;position:absolute;left:0.00pt;top:11880.00pt;z-index:-1;"><img style="width:612pt;height:792pt;" src="outputfile-892646128.htm_files\outputfile-892646128_background15.png"></span>
<SPAN STYLE="position:absolute;left:71.76pt;top:12672.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:13378.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 17 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:12758.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">An adequate HPLC/MS method (GRM010.01A) is also available for enforcing tolerances</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12772.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">in livestock commodities.  This method determines residues of both parent and the metabolite</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12786.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">CGA-304075 (free and conjugated), expressed as parent.  The LOQ is 0.01 ppm for each analyte</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12800.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">for a combined LOQ of 0.02 ppm.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:12828.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.3.2 Multiresidue Methods</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:12856.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Data are available depicting the recovery of cyprodinil and its metabolite CGA-232449</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12870.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">through FDA Multiresidue method testing protocols (C through E).  Acceptable recoveries were</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12884.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">obtained for cyprodinil in apples fortified at 0.40 ppm using Protocol D.  These data were</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12898.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">forwarded to FDA (G. Kramer, 11/28/1995).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:12926.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.4</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:12926.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Residues in Crops</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:12954.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">There is adequate number and geographic location of apple and pear field trials</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12968.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">conducted with a WDG formulation of cyprodinil to support the proposed amended uses on</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12982.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">pome fruit.  Syngenta Crop Protection submitted residue data from 12 apple field trials</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:12996.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">conducted in the U.S. in Zones 1, 2, 5, 9, 10, and 11 and from 6 pear field trials conducted in the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13010.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">U.S. in Zones 1, 10, and 11 using a water-dispersible granular (WDG) formulation containing</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13024.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">75% cyprodinil.  Residues of cyprodinil in/on apples and pears harvested at 0 days after the last</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13038.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">application (DALA) following five broadcast foliar applications of a 75% WDG formulation of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13052.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">cyprodinil at a rate of 0.2286-0.263 lb ai/A/application with a retreatment interval of 6-9 days</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13066.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">were 0.17-1.4 ppm and 0.11-0.73 ppm, respectively.  The data support a reduction of PHI to 0-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13080.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">days for the amended use of the WDG formulation on pome fruit.  The data also support an</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13094.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">increased maximum use rate of 0.20 lb ai/A/application (1.0 lb ai/A/season of cyprodinil) and a</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13108.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">reduced PHI of 14-days for the EW formulation of cyprodinil/difenoconazole.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:13136.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.5</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:13136.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Residues in Livestock</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:13164.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Adequate cattle feeding studies are available for cyprodinil.    Since, apple wet pomace</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13178.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">may be fed locally to dairy cattle, the maximum daily burdens (MDBs) were recalculated for this</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13192.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">action.  The MDB for livestock to cyprodinil was recalculated to be 0.88 ppm for beef cattle, 1.2</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13206.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">ppm for dairy cattle, and 0.005 ppm for swine and poultry.  Based on the proposed amended uses</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13220.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">of cyprodinil on pome fruit, the currently established 0.02 ppm tolerance levels for meat</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13234.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">byproducts of cattle, goats, horses, and sheep are adequate but the currently established tolerance</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13248.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">expression for livestock commodities should be changed to reflect measurement of both parent</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13262.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">and metabolite CGA-304075.  Separate tolerances should be established for residues of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13276.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">cyprodinil and free and conjugated CGA-304075, expressed in parent equivalents, on meat</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13290.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">byproducts of cattle, goats, horses, and sheep at 0.02 ppm (LOQ).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:13318.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.6  Residues in Processed Commodities</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:13464.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:14170.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 18 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:13536.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Based on the submitted apple field trial and available apple processing data (MRID</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13550.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">44186417; DP# D233182, PP# 6F4656, G. Kramer, 2/20/98), the currently established tolerance</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13564.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">for residues of cyprodinil in apple wet pomace will need to be increased from 0.15 ppm to 4.6</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13578.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">ppm to cover the proposed amended uses of cyprodinil on pome fruit.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:13606.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.7</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:13606.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Residues in Rotational Crops</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:13634.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">An adequate  field accumulation study with mustard greens as the primary crop and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13648.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">rotational crops of wheat, lettuce and garden beets planted at plant back intervals (PBIs) of 27 to</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13662.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">32 days showed residues of parent and each metabolite <LOQ in/on all lettuce, garden beet and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13676.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">wheat RAC samples.  This study supports the label specified 30-day PBI and indicates that</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13690.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">rotational crop tolerances are not currently required.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:13718.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.1.8</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.05pt;top:13718.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Storage Stability</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:13746.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">In the submitted field trial study, apple and pear samples were stored frozen (-20°C ±</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13760.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">10°C) for up to 11.7 months prior to analysis.  No storage stability data were submitted with the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13774.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">field trials.  Adequate data are available indicating that cyprodinil is stable in/on peaches, apples,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13788.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">and apple pomace for at least 12 months when stored frozen (DP# D233182, G. Kramer,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13802.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">2/20/98); these data are adequate to support the submitted apple and pear field trial data.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13830.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.2</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.05pt;top:13830.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Drinking Water Profile</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:13858.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.2.1</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.00pt;top:13858.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Environmental Fate and Transport</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:13886.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">The environmental fate data base for cyprodinil is considered substantially complete.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13900.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Cyprodinil has a relatively low solubility in water (13 ppm at pH 7).  Based on its octanol/ water</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13914.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">partition coefficient, it is likely to partition with organic tissues and other organic media.  It is</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13928.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">alkaline in water (pH 9.5 and pKa = 4.44).  It is not likely to volatilize substantially, with a vapor</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13942.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">pressure of 3.80x10</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:167.05pt;top:13940.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">-6</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.70pt;top:13942.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">mmHg and a Henry’s Law constant of 7.04x10</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:402.55pt;top:13940.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">-8</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:412.20pt;top:13942.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Atm-m /mol at 20°C.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:446.70pt;top:13940.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">3</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13956.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Cyprodinil binds to sediment and particulate. It appears to be a persistent compound under most</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13970.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">conditions, except aerobic soil metabolism, as demonstrated in laboratory studies.  Cyprodinil</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13984.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">appears to bind strongly to particulate and sediment, showing relatively low soil mobility (K</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:516.60pt;top:13989.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">OC</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:13998.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">range 1550 to 2030); its potential for groundwater contamination appears to be low.  However,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14012.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">due to its high persistence under aquatic conditions, aquifers that lie below areas that have low</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14026.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">organic content and coarse textured soils or shallow leaky aquifers could be prone to</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14040.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">contamination.  Even though buffer zones can ameliorate moderately the level of spray drift, the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14054.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">potential for runoff still exists for long periods of time.  Cyprodinil’s high affinity to sorb to soil</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14068.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">and particulate suggests the potential for runoff in eroded particles.  This stability and binding to</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14082.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">particulate and organic matter (aerobic and anaerobic conditions) suggests that cyprodinil</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14096.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">residues in sediments could contribute to a possible resuspension of the compound through</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14110.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">mixing and mass balance for an extended period.  Degradates of cyprodinil include 4-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14124.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">cyclopropyl-6-methyl-2-amine-pyrimidine, CGA-275535 (slightly mobile), CGA-321915</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14138.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">(mobile to moderately mobile), and CGA-249287 (moderately mobile) (the degradate identified</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:14256.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:14962.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 19 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14328.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">of concern in this assessment; 11.7% at 28 days in the aerobic soil metabolism study, and 14.2%</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14342.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">in the aerobic aquatic metabolism study).  The water residues of concern as determined by</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14356.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">MARC are the parent and CGA 249287 (4-cyclopropyl-6-methylpyrimidin-2-amine) (D292557,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14370.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">6/8/03).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:14398.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.2.2</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:144.05pt;top:14398.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Estimated Drinking Water Concentrations</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:14426.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Drinking water residues were incorporated directly into the chronic dietary analysis</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14440.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">(“water, direct, all sources” and “water, indirect, all sources”) and were provided by the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14454.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Environmental Fate and Effects Division (EFED).  EFED generated the surface water estimates</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14468.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">using the linked PRZM and EXAMS tier 2 aquatic models.  Ground water estimates were</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14482.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">calculated using the Tier 1 Screening Concentration in Ground Water model.   Estimated</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14496.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Drinking Water Concentrations (EDWCs) for cyprodinil and its metabolite CGA-249287 were</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14510.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">derived based on a maximum application rate of 1.4 lb a.i./A on grapes.  Combined surface water</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14524.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">EDWCs for cyprodinil and the CGA-249287 metabolite used in the exposure assessment, are</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14538.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">provided in Table 9.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.40pt;top:14566.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 9.  EDWCs for the Cyprodinil Human Health Risk Assessment</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:14565pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:14565pt;width:455pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:526pt;top:14565pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:14566pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:526pt;top:14566pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.40pt;top:14579.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Drinking Water Source</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:278.70pt;top:14579.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Peak ( g/L)</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:406.20pt;top:14579.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Annual Mean ( g/L)</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:14577pt;width:455pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:14578pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:233pt;top:14578pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:373pt;top:14578pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:526pt;top:14578pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.40pt;top:14591.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Surface Water</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.55pt;top:14591.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">34.79</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:439.85pt;top:14591.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">24.65</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:14590pt;width:455pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:14590pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:233pt;top:14590pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:373pt;top:14590pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:526pt;top:14590pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.40pt;top:14602.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Ground Water</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:291.35pt;top:14602.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">0.0861</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:437.60pt;top:14602.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">0.0861</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:14601pt;width:455pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:14601pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:14612pt;width:162pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:233pt;top:14601pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:234pt;top:14612pt;width:139pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:373pt;top:14601pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:373pt;top:14612pt;width:152pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:526pt;top:14601pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:526pt;top:14612pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14627.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.3</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:14627.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Dietary and Drinking Water Exposure and Risk</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:14655.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Screening-level acute and chronic dietary and drinking water exposure and risk</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14669.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">assessment was conducted using the Dietary Exposure Evaluation Model with the Food</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14683.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Commodity Intake Database (DEEM-FCID™).  Dietary risk assessment incorporates both</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14697.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">exposure and toxicity of a given pesticide.  For acute and chronic dietary assessments, the risk is</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14711.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14725.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">concluded will result in no unreasonable adverse health effects).  This dose is referred to as the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14739.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">population adjusted dose (PAD).  The PAD is equivalent to the reference dose (RfD) divided by</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14753.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">the additional Safety Factor, if applied. For acute and non-cancer chronic exposures, HED is</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14767.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">concerned when estimated dietary risk exceeds 100% of the PAD.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:14795.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.3.1  Acute Dietary and Drinking Water Analysis</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:14823.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">A screening level acute dietary exposure analysis was performed for the population</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14837.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">subgroup females 13-49 only.  No acute endpoint was identified for the remaining population</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14851.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">subgroups.  Tolerance level residues and 100 crop treated assumptions were used.  DEEM</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14865.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">default and empirical processing factors were used to modify the tolerance values.  The acute</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14879.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">analysis incorporated the 1 in 10 year peak surface drinking water estimate from application of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14893.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">cyprodinil to grapes.  The resulting 95th percentile acute exposure estimate for females 13-49</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:14907.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">years old is not of concern to HED (4% acute population adjusted dose (aPAD)).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:74.15pt;top:14935.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 10:  Summary of Acute Dietary Exposure and Risk for Cyprodinil</FONT></FONT></u></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:14934pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:14934pt;width:459pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:14934pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:14934pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:14934pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:14946pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;left:71.76pt;top:15048.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:15754.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 20 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:369.55pt;top:15121.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acute (95th Percentile)</FONT></FONT></u></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15120pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15120pt;width:459pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15120pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15120pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:197pt;top:15120pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:305pt;top:15120pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15120pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:74.15pt;top:15126.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Population Subgroup</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:212.35pt;top:15126.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">aPAD (mg/kg/day)</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:321.85pt;top:15132.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Exposure (mg/kg/day)</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:463.85pt;top:15132.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">%aPAD</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15131pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:197pt;top:15131pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15132pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:197pt;top:15132pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:305pt;top:15132pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:15132pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15132pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:74.15pt;top:15145.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Females 13-49 years old</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:245.75pt;top:15145.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">1.5</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:355.25pt;top:15145.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.0554</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:478.95pt;top:15145.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">4</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15144pt;width:459pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15144pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:197pt;top:15144pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:305pt;top:15144pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:15144pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:432pt;top:15155pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15144pt;width: 1pt;height:10pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15155pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:15170.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">4.3.2  Chronic Dietary and Drinking Water Analysis</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:15198.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">A moderately refined chronic dietary exposure analysis was performed for the general</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15212.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">U.S. population and various population subgroups.  Average field trial residues for pome fruit,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15226.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">tolerance level residues for the remaining commodities, and 100 % crop treated assumptions</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15240.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">were used.   DEEM default and empirical processing factors were used to modify the tolerance</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15254.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">values.  The chronic analysis incorporated the 10 year average surface drinking water estimate</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15268.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">from application of cyprodinil to grapes.  Chronic dietary risk estimates are not of concern for</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15282.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">general population or other population subgroups.  The subgroup with the highest risk estimate</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15296.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">was children 1-2 years old with a cPAD of 86%.  The cPAD for the general U.S. population was</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15310.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">43%.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:74.15pt;top:15338.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 11:  Summary of Chronic Dietary Exposure and Risk for Cyprodinil</FONT></FONT></u></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15337pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15337pt;width:459pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15337pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15337pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15337pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:401.05pt;top:15350.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Chronic</FONT></FONT></u></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15349pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:197pt;top:15349pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:305pt;top:15349pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15349pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:89.50pt;top:15356.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Population Subgroup</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:212.70pt;top:15356.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">cPAD (mg/kg/day)</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:321.85pt;top:15362.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Exposure (mg/kg/day)</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:462.80pt;top:15362.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">% cPAD</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15360pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:197pt;top:15360pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15360pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:197pt;top:15360pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:305pt;top:15360pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:15360pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15360pt;width: 1pt;height:12pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:74.15pt;top:15374.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><u><FONT STYLE="font-size: 9.96pt">General U.S. Pop</FONT></u><FONT STYLE="font-size: 9.96pt">ulation </FONT></FONT><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.0129</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:476.50pt;top:15374.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15373pt;width:459pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15374pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:197pt;top:15374pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:305pt;top:15374pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:15374pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15374pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:74.15pt;top:15385.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">All Infants (< 1 year old)</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:355.25pt;top:15385.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.0131</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:476.50pt;top:15385.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">44</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15385pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:197pt;top:15385pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:305pt;top:15385pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:15385pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15385pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:74.15pt;top:15397.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Children 1-2 years old</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:355.25pt;top:15397.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.0257</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:476.50pt;top:15397.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">86</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15397pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:197pt;top:15397pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:305pt;top:15397pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:15397pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15397pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:74.15pt;top:15409.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Children 3-5 years old</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:355.25pt;top:15409.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.0216</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:476.50pt;top:15409.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">72</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15408pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:197pt;top:15408pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:305pt;top:15408pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:15408pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15408pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:74.15pt;top:15420.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Children 6-12 years old</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:355.25pt;top:15420.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.0143</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:476.50pt;top:15420.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">48</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15420pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:197pt;top:15420pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:305pt;top:15420pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:15420pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15420pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:74.15pt;top:15432.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Youth 13-19 years old</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:355.25pt;top:15432.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.0107</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:476.50pt;top:15432.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">36</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15431pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:197pt;top:15431pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:305pt;top:15431pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:15431pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15431pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:74.15pt;top:15443.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Adults 20-49 years old</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:355.25pt;top:15443.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.0121</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:476.50pt;top:15443.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">40</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15443pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:197pt;top:15443pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:305pt;top:15443pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:15443pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15443pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:74.15pt;top:15455.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Adults 50+ years old</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:355.25pt;top:15455.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.0117</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:476.50pt;top:15455.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">39</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15454pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:197pt;top:15454pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:305pt;top:15454pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:15454pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15454pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:74.15pt;top:15466.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Females 13-49 years old</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:240.80pt;top:15419.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.027</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:355.25pt;top:15466.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.0125</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:476.50pt;top:15466.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">42</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:15466pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:197pt;top:15466pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:198pt;top:15477pt;width:107pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:305pt;top:15466pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:15466pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15466pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:530pt;top:15477pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15492.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">5.0</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:107.95pt;top:15492.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">AGGREGATE EXPOSURE AND RISK ASSESSMENT</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:15520.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">In accordance with the FQPA, when there are potential residential exposures to a</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15534.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">pesticide, aggregate risk assessment must consider exposures from three major routes: oral,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15548.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">dermal, and inhalation.  There are three sources for these types of exposures:  food, drinking</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15562.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">water, and residential uses.  In an aggregate assessment, exposures from relevant sources are</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15576.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">added together and compared to quantitative estimates of hazard (e.g., a NOAEL or PAD), or the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15590.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">risks themselves can be aggregated.  When aggregating exposures and risks from various</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15604.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">sources, HED considers both the route and duration of exposure.  An aggregate risk assessment</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15618.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">of combined short-term dermal, inhalation and oral exposure is required for residential handlers</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15632.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">because PODs selected for these exposure routes are based on common toxicological effects</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15646.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">(i.e., liver effects). MOEs for residential exposure are provided in Table 12.  Aggregate MOEs</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:15660.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">for food, water and residential exposure are provided in Table 13.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:41.40pt;top:15689.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 12. Estimated Cyprodinil Exposure & MOEs for Short-Term Residential Handler Exposure - LOC/MOE = 100;</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:35pt;top:15687pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:35pt;top:15687pt;width:545pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:580pt;top:15687pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:35pt;top:15688pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:35pt;top:15701pt;width:544pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:580pt;top:15688pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:580pt;top:15701pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;left:71.76pt;top:15840.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:16546.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 21 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:54.00pt;top:15924.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Exposure</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:54.05pt;top:15936.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Scenario</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:91.15pt;top:15935.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">1</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:119.65pt;top:15913.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Inhalation</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:132.35pt;top:15924.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Unit</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:121.50pt;top:15936.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Exposure</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:121.30pt;top:15948.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(ug/lb ai)</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:161.40pt;top:15946.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">2</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:184.20pt;top:15919.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Dermal</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:181.00pt;top:15930.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Unit Exp</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:177.25pt;top:15942.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(mg/lb ai)</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:220.00pt;top:15941.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">2</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:245.10pt;top:15919.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">App</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:244.25pt;top:15930.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Rate</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:235.25pt;top:15942.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(lbai/G)</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:270.00pt;top:15941.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">3</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.20pt;top:15919.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Area</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:286.85pt;top:15930.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Treated</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:285.00pt;top:15942.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(G/day)</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:319.20pt;top:15941.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">4</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:333.90pt;top:15919.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Inhalation</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:333.90pt;top:15930.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Dose</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:333.90pt;top:15942.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(m/k/d)</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:366.90pt;top:15941.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">5</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:394.60pt;top:15924.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Inhalatio</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:396.40pt;top:15936.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">n MOE</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:428.30pt;top:15935.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">6</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:449.70pt;top:15919.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Dermal</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:455.45pt;top:15930.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Dose</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:447.60pt;top:15942.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(m/k/d)</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:480.60pt;top:15941.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">7</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:496.90pt;top:15924.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Dermal</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:499.45pt;top:15936.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MOE</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:523.25pt;top:15935.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">8</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:550.20pt;top:15924.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Agg</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:544.45pt;top:15936.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MOE</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:568.25pt;top:15935.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">9</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:35pt;top:15912pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:35pt;top:15912pt;width:293pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:328pt;top:15912pt;width:58pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:386pt;top:15912pt;width:194pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:580pt;top:15912pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:35pt;top:15912pt;width: 1pt;height:46pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:112pt;top:15912pt;width: 1pt;height:46pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:15912pt;width: 1pt;height:46pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:229pt;top:15912pt;width: 1pt;height:46pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:278pt;top:15912pt;width: 1pt;height:46pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:328pt;top:15912pt;width: 1pt;height:46pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:386pt;top:15912pt;width: 1pt;height:46pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:440pt;top:15912pt;width: 1pt;height:46pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:490pt;top:15912pt;width: 1pt;height:46pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:535pt;top:15912pt;width: 1pt;height:46pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:580pt;top:15912pt;width: 1pt;height:46pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:208.80pt;top:15961.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Mixing/Loading/Applying WDG – Ornmentals</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:35pt;top:15959pt;width:293pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:328pt;top:15959pt;width:58pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:386pt;top:15959pt;width:194pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:35pt;top:15959pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:580pt;top:15959pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:41.40pt;top:15973.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Handheld Pump</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:43.85pt;top:15985.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Sprayer</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:135.50pt;top:15979.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">3.8 56</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:334.30pt;top:15979.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.0000004 > 1000000 0.0017 37000 37000</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:35pt;top:15972pt;width:293pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:328pt;top:15972pt;width:53pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:382pt;top:15972pt;width:198pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:35pt;top:15973pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:112pt;top:15973pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:15973pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:229pt;top:15973pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:278pt;top:15973pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:328pt;top:15973pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:382pt;top:15973pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:440pt;top:15973pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:490pt;top:15973pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:535pt;top:15973pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:580pt;top:15973pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:41.40pt;top:15998.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Backpack Spray</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:136.75pt;top:15997.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">30</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:194.00pt;top:15997.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">5.1</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:336.75pt;top:15997.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.000003</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:390.20pt;top:15997.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">> 1000000</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:452.00pt;top:15997.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.0002</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:498.05pt;top:15997.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">410000</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:543.05pt;top:15997.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">400000</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:35pt;top:15996pt;width:194pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:278pt;top:15996pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:328pt;top:15996pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:328pt;top:15996pt;width:53pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:382pt;top:15996pt;width:198pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:35pt;top:15996pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:112pt;top:15996pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:15996pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:229pt;top:15996pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:278pt;top:15996pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:328pt;top:15996pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:382pt;top:15996pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:440pt;top:15996pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:490pt;top:15996pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:535pt;top:15996pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:580pt;top:15996pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:41.40pt;top:16012.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Hose-end Spray</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:135.50pt;top:16011.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">1.5 39</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:240.55pt;top:15992.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.0014 5</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:334.30pt;top:16011.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.0000002 > 1000000  0.0012</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:500.55pt;top:16011.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">53000  53000</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:35pt;top:16009pt;width:194pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:278pt;top:16009pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:328pt;top:16009pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:328pt;top:16009pt;width:53pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:382pt;top:16009pt;width:198pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:35pt;top:16010pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:35pt;top:16023pt;width:76pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:112pt;top:16010pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:112pt;top:16023pt;width:58pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:16010pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:171pt;top:16023pt;width:58pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:229pt;top:16010pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:229pt;top:16023pt;width:49pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:278pt;top:16010pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:279pt;top:16023pt;width:49pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:328pt;top:16010pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:328pt;top:16023pt;width:53pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:382pt;top:16010pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:382pt;top:16023pt;width:58pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:440pt;top:16010pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:441pt;top:16023pt;width:49pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:490pt;top:16010pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:490pt;top:16023pt;width:44pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:535pt;top:16010pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:535pt;top:16023pt;width:44pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:580pt;top:16010pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:580pt;top:16023pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16023.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 4.98pt">1</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.75pt;top:16024.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">Use patterns are from the proposed labels.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16032.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">2</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:76.50pt;top:16034.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">Baseline unit exposures are assumed for all residential exposure senarios. Unit exposures for and-held pump sprayer and hose-end sprayer are</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16044.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">from the ORETF study OMA-005 MRID 445185-01   Unit exposures for backpack sprayer are reported in the PHED Surrogate Exposure Guide</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16053.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">dated August 1998.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16061.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">3</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:76.95pt;top:16064.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">Application rates are based on maximum values based on proposed label presented as lb ai/gallon).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16072.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">4</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:76.95pt;top:16074.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">Amount treated is based on the area or gallons that can be reasonably applied in a single day for each exposure scenario of concern based on the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16084.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">application method and formulation/packaging type. (Standard EPA/OPP/HED values).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16092.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">5</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:76.95pt;top:16094.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">Inhalation dose (mg/kg/day) = [unit exposure (ug/lb ai) * 0.001 mg/ug unit conversion * Inhalation absorption (100%) * Application rate (lb</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16104.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">ai/acre or lb ai/gallon) * Daily area treated/amount handled (acres or gallons)] / Body weight (60 kg).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16112.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">6</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:76.95pt;top:16114.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">Inhalation MOE = short-term endpoint for inhalation (NOAEL 62 mkd)/ Daily Inhalation Dose.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16123.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">7</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:76.95pt;top:16125.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">Dermal Dose (mg/kg/day) = [unit exposure (mg/lb ai) * Application rate (lb ai/acre or lb ai/gallon) * Daily area treated/amount handled (acres or</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16134.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">gallons) * Dermal Absorption Factor (30%)] / Body weight (60 kg).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16143.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">8</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:76.95pt;top:16145.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">Dermal MOE = short-term endpoint for dermal (NOAEL 62 mkd)/Daily Dermal Dose.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16153.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">9</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:78.95pt;top:16155.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">Aggregate MOE = Inhalation/Dermal short-term endpoint (NOAEL (62 mkd)/Daily Inhalation Dose + Daily Dermal Dose</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:54.70pt;top:16180.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 13.  Short-Term Aggregate Risk Assessment for Cyprodinil</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:53pt;top:16176pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:53pt;top:16176pt;width:504pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:54pt;top:16177pt;width:503pt;height: 1pt;background-color:#ffffff;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:557pt;top:16176pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:557pt;top:16176pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:53pt;top:16177pt;width: 1pt;height:14pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:557pt;top:16177pt;width: 1pt;height:14pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:62.30pt;top:16193.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Residential Handler  Food + Water Exposure</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:65.00pt;top:16204.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Exposure Scenario </FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:180.40pt;top:16204.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(mg/kg/day)</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:233.30pt;top:16203.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">1</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:284.20pt;top:16193.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Residential Exposure,</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:302.20pt;top:16204.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(mg/kg/day)</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:356.05pt;top:16203.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">2</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:467.35pt;top:16193.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MOE</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:417.55pt;top:16204.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Food + Water + Residential</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:537.80pt;top:16203.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">3</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:53pt;top:16191pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:54pt;top:16191pt;width:101pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:54pt;top:16192pt;width:101pt;height: 1pt;background-color:#ffffff;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:155pt;top:16191pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:156pt;top:16191pt;width:104pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:156pt;top:16192pt;width:104pt;height: 1pt;background-color:#ffffff;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:260pt;top:16191pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:261pt;top:16191pt;width:138pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:261pt;top:16192pt;width:138pt;height: 1pt;background-color:#ffffff;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:400pt;top:16191pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:400pt;top:16191pt;width:156pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:400pt;top:16192pt;width:156pt;height: 1pt;background-color:#ffffff;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:557pt;top:16191pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:53pt;top:16192pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:155pt;top:16192pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:260pt;top:16192pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:400pt;top:16192pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:557pt;top:16192pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:216.05pt;top:16219.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.00pt">Mixing/Loading/Applying WDG – Ornmentals</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:53pt;top:16215pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:54pt;top:16215pt;width:346pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:400pt;top:16215pt;width:156pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:557pt;top:16215pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:53pt;top:16216pt;width: 1pt;height:14pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:557pt;top:16216pt;width: 1pt;height:14pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:59.95pt;top:16233.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Handheld Pump Spray</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:317.10pt;top:16233.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.0017</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:469.30pt;top:16234.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">4400</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:53pt;top:16230pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:54pt;top:16230pt;width:101pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:155pt;top:16230pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:156pt;top:16230pt;width:104pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:260pt;top:16230pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:261pt;top:16230pt;width:138pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:400pt;top:16230pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:400pt;top:16230pt;width:156pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:557pt;top:16230pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:53pt;top:16231pt;width: 1pt;height:15pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:155pt;top:16231pt;width: 1pt;height:15pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:260pt;top:16231pt;width: 1pt;height:15pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:400pt;top:16231pt;width: 1pt;height:15pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:557pt;top:16231pt;width: 1pt;height:15pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.50pt;top:16249.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Backpack Spray</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:317.05pt;top:16249.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.0002</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:469.35pt;top:16250.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">5200</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:53pt;top:16246pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:54pt;top:16246pt;width:101pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:155pt;top:16246pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:260pt;top:16246pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:261pt;top:16246pt;width:138pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:400pt;top:16246pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:400pt;top:16246pt;width:156pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:557pt;top:16246pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:53pt;top:16247pt;width: 1pt;height:15pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:155pt;top:16247pt;width: 1pt;height:15pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:260pt;top:16247pt;width: 1pt;height:15pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:400pt;top:16247pt;width: 1pt;height:15pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:557pt;top:16247pt;width: 1pt;height:15pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:73.00pt;top:16265.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Hose-end Spray</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:197.30pt;top:16249.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.012</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:317.05pt;top:16265.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0.0012</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:469.30pt;top:16266.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">4400</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:53pt;top:16262pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:54pt;top:16262pt;width:101pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:155pt;top:16262pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:260pt;top:16262pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:261pt;top:16262pt;width:138pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:400pt;top:16262pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:400pt;top:16262pt;width:156pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:557pt;top:16262pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:53pt;top:16263pt;width: 1pt;height:15pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:53pt;top:16278pt;width:102pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:155pt;top:16263pt;width: 1pt;height:15pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:156pt;top:16278pt;width:104pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:260pt;top:16263pt;width: 1pt;height:15pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:261pt;top:16278pt;width:138pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:400pt;top:16263pt;width: 1pt;height:15pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:400pt;top:16278pt;width:156pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:557pt;top:16263pt;width: 1pt;height:15pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:557pt;top:16278pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16278.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 4.98pt">1</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.75pt;top:16279.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">Chronic Dietary/Drinking Water Exposure (mkd) (Adults 20-49 years old)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16287.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">2</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:78.00pt;top:16289.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">Residential Exposure = Inhalation Daily Dose + Dermal Daily Dose (mkd)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16298.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">3</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:76.95pt;top:16300.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">Aggregate Food/Water/Residential MOE = Inhalation/Dermal Short-term endpoint (NOAEL 62 mkd)/Food & Water Exposure (mkd) +</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16309.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">Residential Exposure (mkd)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16333.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">6.0 CUMULATIVE RISK</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:16361.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Section 408(b)(2)(D)(v) of FFDCA requires that, when considering whether to establish,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16375.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">modify, or revoke a tolerance, the Agency consider “available information” concerning the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16389.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">cumulative effects of a particular pesticide's residues and “other substances that have a common</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16403.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">mechanism of toxicity.”</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:16431.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">EPA does not have, at this time, available data to determine whether cyprodinil has a</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16445.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">common mechanism of toxicity with other substances.  Unlike other pesticides for which EPA</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16459.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">has followed a cumulative risk approach based on a common mechanism of toxicity, EPA has</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16473.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">not made a common mechanism of toxicity finding as to cyprodinil  and any other substances</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16487.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">and, cyprodinil does not appear to produce a toxic metabolite produced by other substances</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16501.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">which have tolerances in the U. S.  For the purposes of this tolerance reassessment action,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16515.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">therefore, EPA has not assumed that cyprodinil has a common mechanism of toxicity with other</FONT></FONT></FONT></SPAN>
<span style="color:#000000;background-color:#ffffff;position:absolute;left:0.00pt;top:15840.00pt;z-index:-1;"><img style="width:612pt;height:792pt;" src="outputfile-892646128.htm_files\outputfile-892646128_background20.png"></span>
<SPAN STYLE="position:absolute;left:71.76pt;top:16632.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:17338.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 22 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16704.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">substances.  For information regarding EPA’s efforts to determine which chemicals have a</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16718.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">common mechanism of toxicity and to evaluate the cumulative effects of such chemicals, see the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16732.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">policy statements released by EPA’s OPP concerning common mechanism determinations and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16746.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">procedures for cumulating effects from substances found to have a common mechanism on</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16760.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">EPA’s website at </FONT></FONT><u><FONT COLOR="0000ff"><FONT STYLE="font-size: 12.00pt"><a href="http://www.epa.gov/fedrgstr/EPA_PEST/2002/January/Day_16/">http://www.epa.gov/fedrgstr/EPA_PEST/2002/January/Day_16/</a></FONT></FONT></u><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16788.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">7.0 DATA NEEDS</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:16816.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">7.1 Toxicity</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:16844.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:126.00pt;top:16844.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Immunotoxicity Study (GLN 870.7800) (The available preliminary immunotoxicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:126.00pt;top:16858.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">study is considered Upgradeable/Guideline due to the omission of a NK cell activity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:126.00pt;top:16872.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">assay.  The registrant needs to either submit the assay or provide justification for why</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:126.00pt;top:16886.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">it is not needed.)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:16900.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:126.00pt;top:16900.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Acute Neurotoxicity Study (GLN 870. 6200a)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:16914.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:126.00pt;top:16914.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">28-day dermal toxicity study in rats (GLN 870.3200) (required in prior assessment)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:17424.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:18130.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 23 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:17496.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">APPENDICES</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:17524.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">A.</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:17524.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">TOXICOLOGY DATA SUMMARY</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:17552.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">A.1</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.05pt;top:17552.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Guideline Data Requirements</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17584.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 1. Guideline Data Requirements</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:17580pt;width:468pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:72pt;top:17581pt;width:467pt;height: 1pt;background-color:#e6e6e6;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:539pt;top:17580pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:424.75pt;top:17603.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Technical</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:17598pt;width:278pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:72pt;top:17599pt;width:278pt;height: 1pt;background-color:#e6e6e6;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:351pt;top:17598pt;width:188pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:351pt;top:17599pt;width:188pt;height: 1pt;background-color:#e6e6e6;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:202.40pt;top:17611.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Test</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:378.35pt;top:17622.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Required</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:474.55pt;top:17622.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Satisfied</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:351pt;top:17617pt;width:93pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:351pt;top:17618pt;width:93pt;height: 1pt;background-color:#e6e6e6;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:446pt;top:17617pt;width:93pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:446pt;top:17618pt;width:93pt;height: 1pt;background-color:#e6e6e6;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17641.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.1100    Acute Oral Toxicity .......................................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17652.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.1200    Acute Dermal Toxicity ..................................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17664.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.1300    Acute Inhalation Toxicity ..............................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.55pt;top:17675.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.2400    Primary Eye Irritation ....................................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.55pt;top:17687.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.2500    Primary Dermal Irritation ..............................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.55pt;top:17698.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.2600    Dermal Sensitization......................................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.65pt;top:17641.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.65pt;top:17652.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.65pt;top:17664.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.65pt;top:17675.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.65pt;top:17687.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.65pt;top:17698.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.15pt;top:17641.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.15pt;top:17652.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.15pt;top:17664.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.15pt;top:17675.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.15pt;top:17687.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.15pt;top:17698.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:17637pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:350pt;top:17637pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:445pt;top:17637pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:539pt;top:17637pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:17637pt;width: 1pt;height:75pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:350pt;top:17637pt;width: 1pt;height:75pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:445pt;top:17637pt;width: 1pt;height:75pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:539pt;top:17637pt;width: 1pt;height:75pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17717.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.3100    Oral Subchronic (rodent) ...............................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17728.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.3150    Oral Subchronic (nonrodent) .........................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17740.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.3200    21-Day Dermal ..............................................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17752.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.3250    90-Day Dermal ..............................................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17763.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.3465    90-Day Inhalation..........................................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.60pt;top:17717.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.60pt;top:17728.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.60pt;top:17740.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:393.30pt;top:17752.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">no</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.60pt;top:17763.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.10pt;top:17717.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.10pt;top:17728.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:487.80pt;top:17740.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">no</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:491.10pt;top:17752.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:487.80pt;top:17763.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">no</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:17713pt;width:468pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:17713pt;width: 1pt;height:63pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:350pt;top:17713pt;width: 1pt;height:63pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:445pt;top:17713pt;width: 1pt;height:63pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:539pt;top:17713pt;width: 1pt;height:63pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17782.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.3700a  Developmental Toxicity (rodent)...................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17793.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.3700b  Developmental Toxicity (nonrodent).............................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17805.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.3800    Reproduction .................................................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.65pt;top:17782.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.65pt;top:17793.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.65pt;top:17805.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.15pt;top:17782.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.15pt;top:17793.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.15pt;top:17805.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:17777pt;width:468pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:17778pt;width: 1pt;height:40pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:350pt;top:17778pt;width: 1pt;height:40pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:445pt;top:17778pt;width: 1pt;height:40pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:539pt;top:17778pt;width: 1pt;height:40pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17823.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.4100a  Chronic Toxicity (rodent) ..............................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17835.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.4100b  Chronic Toxicity (nonrodent) ........................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17846.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.4200a  Oncogenicity (rat)..........................................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17858.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.4200b  Oncogenicity (mouse)....................................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17869.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.4300    Chronic/Oncogenicity....................................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:390.15pt;top:17823.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:403.50pt;top:17822.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">a</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.60pt;top:17835.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:390.20pt;top:17846.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:403.50pt;top:17845.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">a</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.60pt;top:17858.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.60pt;top:17872.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.10pt;top:17823.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.10pt;top:17835.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.10pt;top:17846.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.10pt;top:17858.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.10pt;top:17872.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:17819pt;width:468pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:17820pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:350pt;top:17820pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:445pt;top:17820pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:539pt;top:17820pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17891.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.5100    Mutagenicity—Gene Mutation - bacterial .....................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17902.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.5300    Mutagenicity—Gene Mutation - mammalian ................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17914.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.5375    Mutagenicity—Structural Chromosomal Aberrations ...</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17926.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.5900    Mutagenicity—Other Genotoxic Effects .......................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.60pt;top:17891.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.60pt;top:17902.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.60pt;top:17914.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.60pt;top:17929.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.10pt;top:17891.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.10pt;top:17902.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.10pt;top:17914.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.10pt;top:17929.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:17887pt;width:468pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:17887pt;width: 1pt;height:55pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:350pt;top:17887pt;width: 1pt;height:55pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:445pt;top:17887pt;width: 1pt;height:55pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:539pt;top:17887pt;width: 1pt;height:55pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17947.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.6100a  Acute Delayed Neurotox. (hen) .....................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17959.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.6100b  90-Day Neurotoxicity (hen)...........................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17970.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.6200a  Acute Neurotox. Screening Battery (rat)........................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17982.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.6200b  90-Day Neuro. Screening Battery (rat)..........................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:17993.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.6300    Develop. Neuro..............................................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:393.25pt;top:17947.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">no</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:393.25pt;top:17959.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">no</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.60pt;top:17970.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.60pt;top:17982.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:393.25pt;top:17993.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">no</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:491.05pt;top:17947.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:491.05pt;top:17959.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:487.75pt;top:17970.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">no</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.10pt;top:17982.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:491.10pt;top:17993.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:17943pt;width:468pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:17944pt;width: 1pt;height:63pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:350pt;top:17944pt;width: 1pt;height:63pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:445pt;top:17944pt;width: 1pt;height:63pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:539pt;top:17944pt;width: 1pt;height:63pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:18012.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.7485    General Metabolism.......................................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:18023.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.7600    Dermal Penetration ........................................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.50pt;top:18038.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.7800    Immunotoxicity..............................................................</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.65pt;top:18012.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:393.30pt;top:18023.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">no</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:391.65pt;top:18035.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.15pt;top:18012.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:486.15pt;top:18023.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">yes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:487.80pt;top:18035.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">no</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:71pt;top:18008pt;width:468pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:18008pt;width: 1pt;height:46pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:18054pt;width:279pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:350pt;top:18008pt;width: 1pt;height:46pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:351pt;top:18054pt;width:93pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:445pt;top:18008pt;width: 1pt;height:46pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:445pt;top:18054pt;width:93pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:539pt;top:18008pt;width: 1pt;height:46pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:539pt;top:18054pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:18055.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.00pt">a </FONT><FONT STYLE="font-size: 9.96pt">Guideline 870.4300 satisfies guideline 870.4100a and 870.4200a.</FONT></FONT></FONT></SPAN>
<span style="color:#000000;background-color:#ffffff;position:absolute;left:0.00pt;top:17424.00pt;z-index:-1;"><img style="width:612pt;height:792pt;" src="outputfile-892646128.htm_files\outputfile-892646128_background22.png"></span>
<SPAN STYLE="position:absolute;left:71.76pt;top:18216.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:18922.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 24 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:18288.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">A.2</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.05pt;top:18288.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Toxicity Profiles</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:82.10pt;top:18317.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 1  Acute Toxicity of Cyprodinil.</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18316pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18316pt;width:465pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:537pt;top:18316pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18316pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:537pt;top:18316pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:84.05pt;top:18329.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Guideline No.</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:187.00pt;top:18329.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Study Type</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:282.00pt;top:18329.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MRIDs #</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:367.00pt;top:18329.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Results</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:446.75pt;top:18329.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Toxicity Category</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18328pt;width:259pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:333pt;top:18328pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:18328pt;width:106pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18328pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:152pt;top:18328pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:269pt;top:18328pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:332pt;top:18328pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:18328pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:537pt;top:18328pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:94.70pt;top:18341.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.1100 Acute Oral</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:281.45pt;top:18341.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709014 LD</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:354.55pt;top:18345.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">50</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:363.45pt;top:18341.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">= 2796 mg/kg</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:480.10pt;top:18341.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">III</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18340pt;width:259pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:333pt;top:18340pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:18340pt;width:106pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18340pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:152pt;top:18340pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:269pt;top:18340pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:332pt;top:18340pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:18340pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:537pt;top:18340pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:94.70pt;top:18353.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.1200 Acute Dermal</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:281.45pt;top:18353.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709016 LD</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:354.55pt;top:18358.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">50</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:363.45pt;top:18353.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">> 2000 mg/kg</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:480.10pt;top:18353.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">III</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18352pt;width:259pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:18352pt;width:106pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18353pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:152pt;top:18353pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:269pt;top:18353pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:332pt;top:18353pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:18353pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:537pt;top:18353pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:94.70pt;top:18365.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.1300 Acute Inhalation</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:281.50pt;top:18365.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709018 LC</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:354.00pt;top:18370.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><u><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">50</FONT></FONT></u></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:362.95pt;top:18365.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">= 1.2 mg/L</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:480.10pt;top:18365.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">III</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18364pt;width:259pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:18364pt;width:106pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18365pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:152pt;top:18365pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:269pt;top:18365pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:332pt;top:18365pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:18365pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:537pt;top:18365pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:94.70pt;top:18377.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.2400</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:161.20pt;top:18377.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Primary Eye Irritation</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:281.50pt;top:18377.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709021</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:341.25pt;top:18377.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mild/mod irritant</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:480.15pt;top:18377.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">III</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18376pt;width:259pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:18376pt;width:106pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18377pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:152pt;top:18377pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:269pt;top:18377pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:332pt;top:18377pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:18377pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:537pt;top:18377pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:94.70pt;top:18389.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.2500</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:161.25pt;top:18389.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Primary Skin Irritation</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:281.60pt;top:18389.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709022</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:341.35pt;top:18389.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">very slight irritant</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:479.90pt;top:18389.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">IV</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18388pt;width:259pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:333pt;top:18388pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:18388pt;width:106pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18389pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:152pt;top:18389pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:269pt;top:18389pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:332pt;top:18389pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:18389pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:537pt;top:18389pt;width: 1pt;height:11pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:94.70pt;top:18401.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.2600 Dermal Sensitization  43709024 positive NA</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:281.50pt;top:18413.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">44392102 </FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18400pt;width:259pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:333pt;top:18400pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:18400pt;width:106pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18401pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:73pt;top:18424pt;width:79pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:152pt;top:18401pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:153pt;top:18424pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:269pt;top:18401pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:270pt;top:18424pt;width:62pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:332pt;top:18401pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:333pt;top:18424pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:431pt;top:18401pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:432pt;top:18424pt;width:105pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:537pt;top:18401pt;width: 1pt;height:23pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:537pt;top:18424pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:18440.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 2..  Toxicity Profile of Cyprodinil Technical.</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:18438pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:18438pt;width:470pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:18438pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:18438pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:18439pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:18439pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:89.75pt;top:18461.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Guideline No./</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:96.00pt;top:18472.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Study Type</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:190.60pt;top:18461.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MRID No. (year)/</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:184.85pt;top:18472.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Classification /Doses</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:398.45pt;top:18461.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Results</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:18453pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:18453pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:18453pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:18453pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:18453pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:18453pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:18453pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:18454pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:18454pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:18454pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:18454pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:18494.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.3100</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:18505.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">90-Day oral toxicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:18517.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(mouse)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18494.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709027 (1991)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18505.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18517.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0, 500, 2000, 6000 ppm</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18528.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">M: 0, 73.3, 257, 849</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18540.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18552.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">F: 0, 103, 349, 1121</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18563.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:18494.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">NOAEL = 73.3/103 mg/kg/day, M/F</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:18505.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 257/349 mg/kg/day, M/F, based on</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:18517.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">histopathological changes in the liver</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:18486pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:18486pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:18486pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:18486pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:18487pt;width: 1pt;height:90pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:18487pt;width: 1pt;height:90pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:18487pt;width: 1pt;height:90pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:18487pt;width: 1pt;height:90pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:18585.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.3100</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:18596.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">90-Day oral toxicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:18608.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(rat)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18585.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709026 (1991)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18596.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18608.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0, 50, 300, 2000, 12,000</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18619.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">ppm</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18631.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">M: 0, 3.14, 19, 134, 810</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18643.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18654.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">F: 0, 3.24, 19.3, 137, 803</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18666.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:18585.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">NOAEL =3.14 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:18596.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 19 mg/kg/day based on increased tubular kidney</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:18608.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">lesions in males</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:18577pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:18577pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:18577pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:18577pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:18577pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:18577pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:18577pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:18578pt;width: 1pt;height:101pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:18578pt;width: 1pt;height:101pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:18578pt;width: 1pt;height:101pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:18578pt;width: 1pt;height:101pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:18687.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Non-guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:18699.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">28-Day Feeding/</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:18710.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Range Finding</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:18722.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(rat)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18687.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43866301 (1989)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18699.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/Non-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18711.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18722.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0, 100, 600, 3000, 15000</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18734.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">ppm</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18745.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">M: 10.3, 64.8, 316, 1460</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18757.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18768.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">F: 0, 10.1, 62.2, 299,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18780.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">1390 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:18687.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">NOAEL = 64.8/62.2 mg/kg/day, M/F</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:18699.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 316/299 mg/kg/day, M/F, based on lower body-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:18711.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">weight gains, microcytosis, increase cholesterol and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:18722.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">phospholipid levels, and hepatocyte hypertrophy</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:18680pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:18680pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:18680pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:18680pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:18680pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:18680pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:18680pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:18681pt;width: 1pt;height:124pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:18681pt;width: 1pt;height:124pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:18681pt;width: 1pt;height:124pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:18681pt;width: 1pt;height:124pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:18813.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Non-guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:18825.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">28-Day Gavage/</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:18836.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Range Finding</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:18848.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(rat)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18813.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43737601 (1991)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18825.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/Non-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18836.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18848.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0, 10, 100 1000</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18859.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:18813.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">NOAEL = 10 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:18825.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 100 mg/kg/day based on increased liver weights</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:18836.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">and abnormalities in liver morphology</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:18806pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:18806pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:18806pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:18806pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:18806pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:18806pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:18806pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:18807pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:18807pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:18807pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:18807pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:18881.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.3150</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:18893.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">90-Day oral toxicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18881.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709028 (1991)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:18893.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/Guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:18881.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">NOAEL =210/232 mg/kg/day, M/F</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:18893.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 560/581 mg/kg/day, M/F, based on lower body-</FONT></FONT></FONT></SPAN>
<span style="position:absolute;font-size:0;left:70pt;top:18873pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:71pt;top:18873pt;width:98pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:169pt;top:18873pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:170pt;top:18873pt;width:116pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:286pt;top:18873pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:287pt;top:18873pt;width:253pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:540pt;top:18873pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:70pt;top:18875pt;width: 1pt;height:30pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:70pt;top:18904pt;width:99pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:169pt;top:18875pt;width: 1pt;height:30pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:170pt;top:18904pt;width:116pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:286pt;top:18875pt;width: 1pt;height:30pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:287pt;top:18904pt;width:253pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:540pt;top:18875pt;width: 1pt;height:30pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:540pt;top:18904pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="color:#000000;background-color:#ffffff;position:absolute;left:0.00pt;top:18216.00pt;z-index:-1;"><img style="width:612pt;height:792pt;" src="outputfile-892646128.htm_files\outputfile-892646128_background23.png"></span>
<SPAN STYLE="position:absolute;left:71.76pt;top:19008.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:19714.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 25 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19081.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 2..  Toxicity Profile of Cyprodinil Technical.</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19080pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19080pt;width:470pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19080pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19080pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19081pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19081pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:89.75pt;top:19102.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Guideline No./</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:96.00pt;top:19113.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Study Type</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:190.60pt;top:19102.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MRID No. (year)/</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:184.85pt;top:19113.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Classification /Doses</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:398.45pt;top:19102.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Results</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19094pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:19094pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19094pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:19094pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19094pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:19094pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19094pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19095pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19095pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19095pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19095pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19129.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(dog)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.05pt;top:19129.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0, 200, 1500, 7000, 20000</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19140.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">ppm</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19152.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">M: 0, 6.07, 45.85, 210.33,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19164.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">559.66 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19175.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">F: 0, 6.79, 52.75, 231.93,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19187.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">580.95 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19129.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">weight gains and decreased food consumption in both sexes</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19127pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19127pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19127pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19127pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19128pt;width: 1pt;height:72pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19128pt;width: 1pt;height:72pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19128pt;width: 1pt;height:72pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19128pt;width: 1pt;height:72pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19208.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.3200</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19220.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">21/28-Day dermal-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19231.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">toxicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19243.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(rat)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:178.45pt;top:19208.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709029 (1991)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19220.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Unacceptable/</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19231.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19243.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0, 5, 25, 125, 1000</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19255.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19208.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">NOAEL = 25/125 mg/kg/day, F/M</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19220.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 125/1000 mg/kg/day, F/M, based on clinical</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19231.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">signs (hunched posture and/or piloerection).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19201pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:19201pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19201pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:19201pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19201pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:19201pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19201pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19202pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19202pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19202pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19202pt;width: 1pt;height:66pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19276.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.3700a</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19288.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Prenatal</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19299.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">developmental</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19311.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(rat)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19276.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709033 (1991)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19288.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/Guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19299.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0, 20, 200, 1000</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19311.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19276.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Maternal NOAEL = 200 mg/kg/day</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19288.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 1000 mg/kg/day based on lower body-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19300.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">weight/body-weight gain and reduced food consumption</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19311.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Developmental NOAEL = 200 mg/kg/day</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19323.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 1000 mg/kg/day based on lower mean fetal</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19335.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">weights and increased incidence of delayed ossification</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19269pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19269pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19269pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19269pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19270pt;width: 1pt;height:78pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19270pt;width: 1pt;height:78pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19270pt;width: 1pt;height:78pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19270pt;width: 1pt;height:78pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19356.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.3700b</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19368.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Prenatal</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19379.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">developmental</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19391.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(rabbit)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19356.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709032 (1991)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19368.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/Guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19379.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0, 5, 30, 150, 400</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19391.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19356.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Maternal NOAEL = 150 mg/kg/day</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19368.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 400 mg/kg/day based on decreased body-weight</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19379.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">gain</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19391.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Developmental NOAEL = 150 mg/kg/day</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19403.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 400 mg/kg/day based on slight increase of litters</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19414.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">showing extra (13 ) ribs</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:365.00pt;top:19413.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">th</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19349pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:19349pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19349pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:19349pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19349pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:19349pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19349pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19350pt;width: 1pt;height:78pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19350pt;width: 1pt;height:78pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19350pt;width: 1pt;height:78pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19350pt;width: 1pt;height:78pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19436.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.3800</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19448.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Reproduction and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19459.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">fertility effects</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19471.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(rat)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19436.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709034 (1993)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19448.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/Guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19459.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0, 10, 100, 1000, 4000</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19471.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">ppm</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19482.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">M: 0, 0.7, 6.7, 68, 273</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19494.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19505.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">F: 0, 0.8, 8.2, 81, 326</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19517.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19436.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Maternal/Systemic NOAEL = 81 mg/kg/day</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19448.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 326 mg/kg/day based on decreased body weight</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19459.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">gain in the F0 females during the pre-mating period.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19471.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Reproductive/Developmental NOAEL = 81 mg/kg/day</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19483.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 326 mg/kg/day based on decreased pup weights</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19494.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(F1 and F2)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19428pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:19428pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19428pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:19428pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19428pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:19428pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19428pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19430pt;width: 1pt;height:101pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19430pt;width: 1pt;height:101pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19430pt;width: 1pt;height:101pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19430pt;width: 1pt;height:101pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19539.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.4300</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19550.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Chronic toxicity/</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19562.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Carcinogenicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19573.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(feeding)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19585.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(rat)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19539.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43737602 (1994)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19550.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/Guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19562.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0, 5, 75, 1000, 2000 ppm</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19573.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">M: 0, 0.177, 2.7, 35.6,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19585.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">73.6 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19596.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">F: 0, 0.204, 3.22, 41.2,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19608.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">87.1 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19539.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">NOAEL = 2.7 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19550.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 35.6 mg/kg/day based on degenerative liver</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19562.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">lesions (spongiosis hepatis) in males</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19585.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">No evidence of carcinogenicity</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19531pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:19531pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19531pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:19531pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19531pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:19531pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19531pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19532pt;width: 1pt;height:90pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19532pt;width: 1pt;height:90pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19532pt;width: 1pt;height:90pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19532pt;width: 1pt;height:90pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19630.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.4100b</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19641.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Chronic toxicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19653.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(dog)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19630.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709030 (1991)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19641.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0, 25, 250, 2500, 15000</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19653.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">M: 0, 0.72, 6.87, 65.35,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19664.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">449.25 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19676.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">F: 0, 0.76, 6.80, 67.99,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19630.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">NOAEL = 65.63/67.99 mg/kg/day, M/F</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19641.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 449.25/446.3, M/F, mg/kg/day based on lower</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19653.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">body-weight gains and decreased food consumption and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19664.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">food efficiency</FONT></FONT></FONT></SPAN>
<span style="position:absolute;font-size:0;left:70pt;top:19622pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:71pt;top:19622pt;width:98pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:169pt;top:19622pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:170pt;top:19622pt;width:116pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:286pt;top:19622pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:287pt;top:19622pt;width:253pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:540pt;top:19622pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:70pt;top:19623pt;width: 1pt;height:64pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:70pt;top:19687pt;width:99pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:169pt;top:19623pt;width: 1pt;height:64pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:170pt;top:19687pt;width:116pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:286pt;top:19623pt;width: 1pt;height:64pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:287pt;top:19687pt;width:253pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:540pt;top:19623pt;width: 1pt;height:64pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:540pt;top:19687pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="color:#000000;background-color:#ffffff;position:absolute;left:0.00pt;top:19008.00pt;z-index:-1;"><img style="width:612pt;height:792pt;" src="outputfile-892646128.htm_files\outputfile-892646128_background24.png"></span>
<SPAN STYLE="position:absolute;left:71.76pt;top:19800.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:20506.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 26 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19873.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 2..  Toxicity Profile of Cyprodinil Technical.</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19872pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19872pt;width:470pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19872pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19872pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19873pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19873pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:89.75pt;top:19894.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Guideline No./</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:96.00pt;top:19905.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Study Type</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:190.60pt;top:19894.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MRID No. (year)/</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:184.85pt;top:19905.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Classification /Doses</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:398.45pt;top:19894.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Results</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19886pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:19886pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19886pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:19886pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19886pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:19886pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19886pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19887pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19887pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19887pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19887pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19921.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">446.37 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19919pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19919pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19919pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19919pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19920pt;width: 1pt;height:14pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19920pt;width: 1pt;height:14pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19920pt;width: 1pt;height:14pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19920pt;width: 1pt;height:14pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19942.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.3200</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19954.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Carcinogenicity -</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:19966.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(mouse)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19942.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709031, 44417902</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19954.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/Guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19966.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0, 10, 150, 2000, 5000</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19977.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">ppm</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:19989.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">M: 0, 1.15, 16.1, 212.4,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20000.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">630 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20012.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">F: 0, 1.08, 14.7, 196.3,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20023.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">558.1 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19942.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">NOAEL = 16.1 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19954.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL = 212.4 mg/kg/day based on a dose-related increase</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19966.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">in the incidence of focal and multifocal hyperplasia of the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:19977.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">exocrine pancreas in males</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20001.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">No evidence of carcinogenicity</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19935pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:19935pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19935pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:19935pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19935pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:19935pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19935pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:19936pt;width: 1pt;height:101pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:19936pt;width: 1pt;height:101pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:19936pt;width: 1pt;height:101pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:19936pt;width: 1pt;height:101pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20039.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.7800</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20051.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Immunotoxicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20062.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(mouse)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20039.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">48293501</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20051.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Upgradeable/Guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20062.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0, 500, 2000, 5000 ppm</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20074.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0, 103.8, 468.3, 1245.3</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20085.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20039.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">NOAEL </FONT></FONT><FONT COLOR="000000"><u><FONT STYLE="font-size: 9.96pt">> </FONT></u><FONT STYLE="font-size: 9.96pt">1245.3 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20051.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">LOAEL > 1245.3 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20062.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">There were no cyprodinil-related effects on absolute,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20074.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">adjusted, or relative spleen or thymus weights; no effects on</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20085.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">specific activity or total activity of splenic IgM antibody-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20097.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">forming cells to the T cell-dependent antigen sRBC.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20037pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:20037pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20037pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:20037pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20037pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:20037pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20037pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20039pt;width: 1pt;height:69pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20039pt;width: 1pt;height:69pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20039pt;width: 1pt;height:69pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20039pt;width: 1pt;height:69pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20110.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.6200b</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20121.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Subchronic</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20133.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Neurotoxicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20110.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">45906101</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20121.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/Guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20133.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">0,80, 800, 8000 ppm</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20144.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">M: 0, 5.8, 54.5, 601</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20156.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">F: 0, 6.3, 58.7, 631</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20167.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20110.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Neurotoxicity NOAEL </FONT></FONT><FONT COLOR="000000"><u><FONT STYLE="font-size: 9.96pt">> </FONT></u><FONT STYLE="font-size: 9.96pt">601 mg/kg/day M; 631 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20121.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">F</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20133.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Neurotoxicity LOAEL > 601 mg/kg/day M; 631 mg/kg/day</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20144.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">F</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20156.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Systemic toxicity NOAEL = 54.5 mg/kg/day M; 58.7</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20167.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg/day F</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20179.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Systemic LOAEL = 601 mg/kg/day M; 631 mg/kg/day F</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20191.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">based on decreased body weight gain and microscopic</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20202.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">lesions in the liver (hepatocellular hypertrophy), kidney</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20214.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(tubular casts) and thyroid gland (follicular cell</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20225.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">hypertrophy)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20108pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20108pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20108pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20108pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20109pt;width: 1pt;height:127pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20109pt;width: 1pt;height:127pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20109pt;width: 1pt;height:127pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20109pt;width: 1pt;height:127pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20244.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.5100</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20256.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Gene Mutation -</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20267.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Bacteria</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20244.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709037 (1990)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20256.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/Guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20244.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">In a reverse gene mutation assay with Salmonella</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20256.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><i><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">typhimurium/Escherichia coli, cyprodinil was negative up to</FONT></FONT></i></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20268.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">concentrations (</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:356.95pt;top:20267.20pt;z-index:3;"><FONT FACE ="Symbol" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">≥</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:362.40pt;top:20268.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">1250  g/plate +/-S9) that produced</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20279.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">reproducible cytotoxicity for the majority of strains.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20292.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Compound insolubility was reported at</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:451.00pt;top:20291.05pt;z-index:3;"><FONT FACE ="Symbol" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">≥</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:456.50pt;top:20292.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">313  g/plate.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20237pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:20237pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20237pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:20237pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20237pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:20237pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20237pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20238pt;width: 1pt;height:68pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20238pt;width: 1pt;height:68pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20238pt;width: 1pt;height:68pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20238pt;width: 1pt;height:68pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20313.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.5300</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20325.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Gene Mutation -</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20336.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><i><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">In vitro mammalian</FONT></FONT></i></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20348.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">cell</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20313.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709036 (1990)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20325.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/Guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20313.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">In a Chinese hamster V79 cell HGPRT forward gene</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20325.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mutation assay, cyprodinil was negative up to cytotoxic</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20337.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">concentrations (</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:356.95pt;top:20336.50pt;z-index:3;"><FONT FACE ="Symbol" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">≥</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:362.40pt;top:20337.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">96.0  g/mL with S9) (</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:454.05pt;top:20336.50pt;z-index:3;"><FONT FACE ="Symbol" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">≥</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:459.50pt;top:20337.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">24  g/mL without</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20349.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">S9).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20306pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:20306pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20306pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:20306pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20306pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:20306pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20306pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20307pt;width: 1pt;height:56pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20307pt;width: 1pt;height:56pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20307pt;width: 1pt;height:56pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20307pt;width: 1pt;height:56pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20370.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.5375</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20382.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Cytogenetics/</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20393.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><i><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">In vitro</FONT></FONT></i></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20405.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Chromosomal</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20417.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Aberration</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20370.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709038 (1991)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20382.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/Guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20370.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">In an in vitro assay for chromosome aberrations in Chinese</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20382.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">hamster ovary (CHO) cells, cyprodinil gave negative results</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20394.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">up to cytotoxic concentrations (</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:419.30pt;top:20393.50pt;z-index:3;"><FONT FACE ="Symbol" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">≥</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:424.75pt;top:20394.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">50  g/mL without S9, 18-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20406.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">or 42-hour cell harvest or</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:396.85pt;top:20405.80pt;z-index:3;"><FONT FACE ="Symbol" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">≥</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:402.30pt;top:20406.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">25  g/mL with S9, 18- hour cell</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20418.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">harvest) or to the highest sub-cytotoxic concentration (50</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20430.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">μg/mLwith S9, 42-hour cell harvest).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20363pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:20363pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20363pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:20363pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20363pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:20363pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20363pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20364pt;width: 1pt;height:79pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20364pt;width: 1pt;height:79pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20364pt;width: 1pt;height:79pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20364pt;width: 1pt;height:79pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20451.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.5395</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20463.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Cytogenetics/</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20474.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><i><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">In vivo bone marrow</FONT></FONT></i></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20451.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709039 (1990)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20463.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/Guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20451.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">In an in vivo bone marrow micronucleus assay, cyprodinil</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20463.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">was negative when administered orally (gavage) at 5000</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20474.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">mg/kg (HDT) to both sexes of Tif:MAGF mice.  No signs of</FONT></FONT></FONT></SPAN>
<span style="position:absolute;font-size:0;left:70pt;top:20444pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:71pt;top:20444pt;width:98pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:169pt;top:20444pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:170pt;top:20444pt;width:116pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:286pt;top:20444pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:287pt;top:20444pt;width:253pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:540pt;top:20444pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:70pt;top:20445pt;width: 1pt;height:44pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:70pt;top:20488pt;width:99pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:169pt;top:20445pt;width: 1pt;height:44pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:170pt;top:20488pt;width:116pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:286pt;top:20445pt;width: 1pt;height:44pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:287pt;top:20488pt;width:253pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:540pt;top:20445pt;width: 1pt;height:44pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:540pt;top:20488pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="color:#000000;background-color:#ffffff;position:absolute;left:0.00pt;top:19800.00pt;z-index:-1;"><img style="width:612pt;height:792pt;" src="outputfile-892646128.htm_files\outputfile-892646128_background25.png"></span>
<SPAN STYLE="position:absolute;left:71.76pt;top:20592.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:21298.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 27 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20665.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 2..  Toxicity Profile of Cyprodinil Technical.</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20664pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20664pt;width:470pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20664pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20664pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20665pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20665pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:89.75pt;top:20686.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Guideline No./</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:96.00pt;top:20697.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Study Type</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:190.60pt;top:20686.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MRID No. (year)/</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:184.85pt;top:20697.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Classification /Doses</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:398.45pt;top:20686.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Results</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20678pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:20678pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20678pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:20678pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20678pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:20678pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20678pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20679pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20679pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20679pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20679pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20713.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">micronucleus</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20713.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">overt toxicity or clear evidence of cytotoxicity for the target</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20724.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">organ were noted at any dose or sacrifice time.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20711pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20711pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20711pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20711pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20712pt;width: 1pt;height:26pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20712pt;width: 1pt;height:26pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20712pt;width: 1pt;height:26pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20712pt;width: 1pt;height:26pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20746.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.5550</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20758.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">UDS</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20746.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709035 (1991)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20758.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/Guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20746.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">In an UDS assay in primary rat hepatocytes, cyprodinil was</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:295.45pt;top:20758.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">negative up to a cytotoxic concentration (80  g/mL)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20738pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:20738pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20738pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:20738pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20738pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:20738pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20738pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20739pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20739pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20739pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20739pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20779.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.7485</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20791.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Metabolism and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20802.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">pharmacokinetics</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20779.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709040 (1992)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20791.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/Guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20779.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Single oral doses (0.5 or 100 mg/kg bw) of phenyl or</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20791.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">pyrimidyl-radiolabelled CGA 219417 (purity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:475.50pt;top:20790.70pt;z-index:3;"><FONT FACE ="Symbol" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">≥</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:483.40pt;top:20791.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">98%) were</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20803.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">administered to Tif:RAIf(SPF) rats, with one low-dose</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20815.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">group receiving unlabelled CGA 219417 (purity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:487.90pt;top:20814.55pt;z-index:3;"><FONT FACE ="Symbol" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">≥</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:495.85pt;top:20815.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">99%) for</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20827.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">2 weeks prior to treatment with radiolabelled compound.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20838.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Absorption was very rapid (t</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:407.65pt;top:20843.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">cmax</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:421.60pt;top:20838.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">= 0.3 hours) with rapid</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20850.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">clearance (t</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:339.25pt;top:20855.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">cmax/2</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:358.25pt;top:20850.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">=1.2 hours).  A minimum of 75% of the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20862.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">administered dose was absorbed.  Excretion was rapid and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20873.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">almost complete, with urine as the principle route of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20885.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">excretion (48-68%), and >90% of the administered dose</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20896.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">detected in the urine and feces within 48 hours.  Excretion,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20908.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">distribution and metabolite profiles were essentially</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20919.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">independent of dose level, pretreatment, and type of label,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20931.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">although there were some quantitative differences sex-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20943.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">dependent qualitative differences in two urinary metabolite</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20954.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">fractions.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20772pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:20772pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20772pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:20772pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20772pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:20772pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20772pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:20773pt;width: 1pt;height:195pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:20773pt;width: 1pt;height:195pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:20773pt;width: 1pt;height:195pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:20773pt;width: 1pt;height:195pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20976.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.7485</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20987.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Metabolism and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:20999.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">pharmacokinetics</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20976.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709041 (1992)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:20987.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Acceptable/guideline</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20976.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Must be considered with MRID 43709040.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:20999.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Excreta (Group D1 and D2) and bile (Group G1) from</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21010.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">radiolabelled CGA 219417-treated Tif:RAIf(SPF) rats of a</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21022.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">previous ADME study (MRID 43709040) were used to</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21034.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">characterize, isolate and identify CGA 219417 metabolites</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21045.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(MRID 43709041).  Eleven metabolites were isolated from</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21057.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">urine, feces and bile, and the metabolic pathways in the rat</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21068.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">were proposed.  All urinary and biliary metabolites (with the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21080.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">exception of 7U) were conjugated with glucuronic acid or</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21092.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">sulfonated, and excreted.  CGA 219417 was almost</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21103.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">completely metabolized by hydroxylation of the phenyl ring</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21115.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(position 4) or pyrimidine ring (position 5), followed by</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21126.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">conjugation.  An alternative pathway involved oxidation of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21138.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">the phenyl ring followed by glucuronic acid conjugation.  A</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21149.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">quantitative sex difference was observed with respect to</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21161.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">sulfonation of the major metabolite that formed 6U.  The</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21173.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">monosulfate metabolite (1U) was predominant in females,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21184.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">whereas equal amounts of mono- and disulfate (6U)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21196.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">conjugates were noted in males.  Most of the significant</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21207.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">metabolites in feces were exocons of biliary metabolites</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21219.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(2U, 3U, 1G).  These were assumed to be deconjugated in</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21231.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">the intestines, partially reabsorbed into the general</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21242.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">circulation, conjugated again, and eliminated renally.  The</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21254.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">major metabolic pathways of CGA 219417 were not</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21265.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">significantly influenced by the dose, treatment regimen, or</FONT></FONT></FONT></SPAN>
<span style="position:absolute;font-size:0;left:70pt;top:20968pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:71pt;top:20968pt;width:98pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:169pt;top:20968pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:170pt;top:20968pt;width:116pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:286pt;top:20968pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:287pt;top:20968pt;width:253pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:540pt;top:20968pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:70pt;top:20969pt;width: 1pt;height:308pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:70pt;top:21276pt;width:99pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:169pt;top:20969pt;width: 1pt;height:308pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:170pt;top:21276pt;width:116pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:286pt;top:20969pt;width: 1pt;height:308pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:287pt;top:21276pt;width:253pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:540pt;top:20969pt;width: 1pt;height:308pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:540pt;top:21276pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="color:#000000;background-color:#ffffff;position:absolute;left:0.00pt;top:20592.00pt;z-index:-1;"><img style="width:612pt;height:792pt;" src="outputfile-892646128.htm_files\outputfile-892646128_background26.png"></span>
<SPAN STYLE="position:absolute;left:71.76pt;top:21384.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:22090.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 28 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:21457.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Table 2..  Toxicity Profile of Cyprodinil Technical.</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:21456pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:21456pt;width:470pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:21456pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:21456pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:21457pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:21457pt;width: 1pt;height:13pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:89.75pt;top:21478.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Guideline No./</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:96.00pt;top:21489.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Study Type</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:190.60pt;top:21478.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MRID No. (year)/</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:184.85pt;top:21489.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Classification /Doses</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:398.45pt;top:21478.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Results</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:21470pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:71pt;top:21470pt;width:98pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:21470pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:170pt;top:21470pt;width:116pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:21470pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:287pt;top:21470pt;width:253pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:21470pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:21471pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:21471pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:21471pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:21471pt;width: 1pt;height:32pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21505.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">sex of the animal.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:70pt;top:21503pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:21503pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:21503pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:21503pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:21504pt;width: 1pt;height:14pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:169pt;top:21504pt;width: 1pt;height:14pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:286pt;top:21504pt;width: 1pt;height:14pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:540pt;top:21504pt;width: 1pt;height:14pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:21526.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">870.7600</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:21538.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Dermal Absorption</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:77.00pt;top:21550.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(rat)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:21526.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">45906102 (1999)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:21538.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">In review</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:176.00pt;top:21550.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">6 µg/cm or 870 µg/cm</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:209.05pt;top:21548.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">2</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:268.60pt;top:21548.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.48pt">2</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21526.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">In a dermal absorption study with CGA 219417 formulated</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21538.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">as SWITCH 62.5 WG in the rat, the maximum systemic</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21550.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">absorption was 21.71% (at 24 hours).  An additional 12% of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21561.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">the applied dose (that is potentially available for absorption)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:293.00pt;top:21573.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">remained on the treated skin at 24 hours.</FONT></FONT></FONT></SPAN>
<span style="position:absolute;font-size:0;left:70pt;top:21519pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:71pt;top:21519pt;width:98pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:169pt;top:21519pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:170pt;top:21519pt;width:116pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:286pt;top:21519pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:287pt;top:21519pt;width:253pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:540pt;top:21519pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:70pt;top:21520pt;width: 1pt;height:67pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:169pt;top:21520pt;width: 1pt;height:67pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:286pt;top:21520pt;width: 1pt;height:67pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:540pt;top:21520pt;width: 1pt;height:67pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:540pt;top:21587pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="color:#000000;background-color:#ffffff;position:absolute;left:0.00pt;top:21384.00pt;z-index:-1;"><img style="width:612pt;height:792pt;" src="outputfile-892646128.htm_files\outputfile-892646128_background27.png"></span>
<SPAN STYLE="position:absolute;left:71.76pt;top:22176.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:22882.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 29 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:22248.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">B.</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:22248.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">STUDIES REVIEWED FOR ETHICAL CONDUCT</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:22276.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">The PHED Task Force, 1995.  The Pesticide Handlers Exposure Database, Version 1.1.  Task</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:22290.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Force members Health Canada, U.S. Environmental Protection Agency, and the National</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:22304.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Agricultural Chemicals Association, released February, 1995.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:22332.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Agricultural Re-entry Task Force (ARTF) data base (SOP #3.1)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:22968.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:23674.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 30 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23040.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">B.</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:23040.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">ADDITIONAL TOXICOLOGY STUDIES</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23066.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Dermal Toxicity – Rat (MRID 43709029)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:23094.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">The HIARC downgraded the 28-day dermal-toxicity study in the rat (MRID 43709029)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23108.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">to Unacceptable/Guideline and recommended the submission of an acceptable 28-day dermal-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23122.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">toxicity study.  This study was reclassified as Unacceptable by the July 9, 2002 HIARC because:</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23136.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">1) Cyprodinil has marginal toxicity via the dermal route (LD</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:363.95pt;top:23141.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.98pt">50</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:375.00pt;top:23136.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">>2000 mg/kg); 2) The chemical</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23150.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">structure does not suggest dermal absorption; 3) There is no pattern of toxicity that is consistent</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23164.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">with the other toxicity studies.  For example, there is a questionable sex specificity (i.e., a 40-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23178.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">fold difference was noted between the original LOAEL for females (25 mg/kg/day) and males</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23192.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">(1000 mg/kg/day) that has not been observed in acute, subchronic or chronic studies in rat, rabbit</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23206.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">or dog test species.  Similarly, clinical signs used to set the LOAEL for females (piloerection</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23220.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">and/or hunched posture) are suggestive of a neurotoxic effect.  However, there is no evidence of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23234.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">neurotoxicity in repeated dose studies throughout the cyprodinil database.  The HIARC also</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23248.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">recommended that the LOAEL/NOAEL for females be increased to 125/25 mg/kg/day based on</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23262.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">both hunched posture and piloerection due to the questionable biological significance of the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23276.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">piloerection seen in females at 25 mg/kg/day in the absence of other signs at the same dose level</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23290.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">in this study.  Based on all these considerations, HIARC concluded that there was a lack</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23304.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">confidence in this study.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23329.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Subchronic Oral Toxicity – Rat (MRID 43866301)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:23357.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">In a range finding subchronic toxicity study (MRID 43866301), CGA-219417</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23371.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">(cyprodinil; >95% ai; Batch No. HE 15083) was administered in the diet to Tif:RAIf(SPF)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23385.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">albino rats, 5 rats/sex/dose level at 0, 100, 600, 3000 or 15000 ppm (males - 0, 10.3, 64.8, 316 or</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23399.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">1460 mg/kg/day; females - 0, 10.1, 62.2, 299 or 1390 mg/kg/day) for 28 days. There was no</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23413.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">effect on mortality and no clinical signs of toxicity. Treatment-related effects included lower</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23427.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">body weight gains in 15000 ppm males (30 %) and slight decreases in 3000 (9%) and 15000 ppm</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23441.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">(10%) females; decreased food consumption in high-dose animals (8-15% lower); decreased</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23455.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">water consumption (10-40 % depending on week), decreased erythrocyte, haemoglobin, and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23469.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">haematocrit levels, and significantly increased cholesterol and phospholipid levels in 3000 and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23483.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">15000 ppm animals; increased absolute and relative liver weights in 3000 and 15000 ppm</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23497.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">females; microcytosis, hepatocyte hypertrophy and thyroid follicular hypertrophy in 3000 and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23511.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">15000 ppm males, hypochromasia in 15000 ppm males, and glycogen depletion in 15000 ppm</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23525.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">males and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23539.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">females. The slight increases in platelets, cholesterol and phospholipid levels at 600 ppm</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23553.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">were not considered to be adverse in this study, as there were no associated histopathological</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23567.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">findings at this dose. The LOAEL is 3000 ppm (316 and 299 mg/kg/day for males and females,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23581.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">respectively) based on lower body weight gains, microcytosis, increased cholesterol and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23595.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">phospholipid levels and hepatocyte hypertrophy. The NOAEL is 600 ppm (64.8 and 62.2</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23609.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">mg/kg/day for males and females, respectively).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:23760.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:24466.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 31 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23860.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Subchronic Feeding Study – Dog (MRID 43709028)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:23888.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">A 3-month study was carried out in Beagle dogs where animals (4/sex/dose) were fed</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23902.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">diets containing 0,200! 1500,  7000 or 20000 ppm (actual concentrations: males - 0, 6.07, 45.87,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23916.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">210.33 or 559.66 mg/kg/day; females- 0, 6.79, 52.75, 231.93 or 580.95 mg/kgfday) CGA</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23930.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">219417.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23944.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">There was no effect on mortality, or clinical chemistry parameters. Vomiting was observed in all</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23958.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">high-dose females during the first week of treatment, and an increase in mean platelet count was</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23972.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">noted in high-dose females at weeks 7 and 13. Lower bodyweight gains (64-76%) and decreased</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:23986.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">food consumption were apparent in high-dose males and females throughout the study period.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24000.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">There was a transient decrease in bodyweight gain and food consumption in 7000 ppm females,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24014.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">which was noted after the first week of treatment only, and this was considered non-adverse. The</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24028.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">LOAEL is 20,000 ppm (males -560, females -581 mg/kg/day) based on lower bodyweight gains</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24042.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">and decreased food consumption in both sexes. The NOAEL is 7000 ppm (males -210, females -</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24056.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">232 mg/kg/day).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24084.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Subchronic Feeding Study – Mice  (MRID 43709027)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24112.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">A 3-month study (MRID 43709027) was carried out in Tif:MAGf(SPF) albino mice where</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24126.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">animais (10 mice/sex/dose) were fed diets containing 0, 500,2000 or 6000 ppm (actual</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24140.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">concentrations: males - 0, 73.3, 257 or 849 mg/kg/day; females -0, 103, 349 or 1121 mg/g’day)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24154.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">of CGA 2i19417 technical (99.5% a.i., Batch No- P 912004).  There was no effect on mortality,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24168.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">or haematology parameters, and no clinical sighs of toxicity. Treatment-related effects included</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24182.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">increased absolute and relative liver weights (112-118 %) in 6000 ppm males, and hepatic</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24196.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">changes in mid- and high dose males and females that consisted of multifocal hepatocyte</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24210.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">necrosis in 2000 and 6000 ppm males (30 % as compared to 0 in the control and low dose</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24224.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">groups) and glycogen depletion in 2000 and 6000 ppm females (10, 10, 70 and 100% from</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24238.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">controls to high dose). The LOAEL is 2000 ppm based on histopathological changes in the liver.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24252.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">The NOAEL is 500 ppm (malts - 73.3; females - 103 mg/kg/day).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24279.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Carcinogenicity Study in Mice (MRID 43709031)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:24307.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">An 18-month oncogenicity study was carried out in Tif:MAGf(SPF)</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24321.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">albino mice where animals (50 mice/sex/dose - carcinogenicity portion, plus 10/sex/dose -</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24335.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">hematology) were fed diets containing 0, 10, 150, 2000 or 5000 ppm (actual concentrations:</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24349.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">males - 0, 1.15, 16.1, 212.4 or 630; females - 0, 1.08, 14.7, 196.3 or 558.1 mg/kg/day) of</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24363.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">CGA 219417 (99.0-99.5% a.i., Batch No. P 912006). There was no effect on mortality, or</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24377.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">hematology parameters, and no clinical signs of toxicity. Treatment-related effects included</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24391.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">lower body weight and body weight gain (males - 10%, females - 27%) at 5000 ppm,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24405.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">reduced food efficiency and increased relative liver weights (16%) in high-dose males and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24419.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">females, and a dose-related increase in minimal to marked pancreatic acinar cell hyperplasia</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24433.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">in 2000 and 5000 ppm males (8, 8, 10, 16, 28% incidence, from control to high dose). The</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:24552.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:25258.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 32 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24624.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">LOAEL was 2000 ppm (males - 212.4 mg/kg/day) based on a dose-related increase in the</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24638.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">incidence of focal and multifocal hyperplasia of the exocrine pancreas in males. The</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24652.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">NOAEL was 150 ppm (males - 16.1 mg/kg/day). This study was tested to adequate levels</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24666.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">based on signs of toxicity in males at 2000 ppm and females at 5000 ppm.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:24694.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Mutagenicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:24722.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">(i) Gene Mutation</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:24750.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">In a reverse gene mutation assay with Salmonella typhimurium/Escherichia coli,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24764.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">cyprodinil was negative up to concentrations ($1250 :g/plate +/-S9) that produced reproducible</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24778.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">cytotoxicity for the majority of strains. Compound insolubility was reported at $313</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24792.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">:g/plate (MRID No. 43709037).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:24820.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">In a Chinese hamster V79 cell HGPRT forward gene mutation assay, cyprodinil was</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24834.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">negative up to cytotoxic concentrations (MRID No. 43709036).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24862.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">(ii). Chromosome Aberrations</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:24890.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">In an in vitro assay for chromosome aberrations in Chinese hamster ovary (CHO) cells,</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24904.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">cyprodinil gave negative results up to cytotoxic concentrations) (MRID No.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24918.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">43709038).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:24946.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">In an in vivo bone marrow micronucleus assay, cyprodinil was negative when</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24960.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">administered orally (gavage) at 5000 mg/kg (HDT) to both sexes of Tif:MAGF mice. No signs</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24974.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">of overt toxicity or clear evidence of cytotoxicity for the target organ were noted at any dose or</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:24988.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">sacrifice time (MRID No. 43709039).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:25016.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">(iii) Other Mutagenic Mechanisms</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:25044.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">In an unscheduled DNA synthesis assay in primary rat hepatocytes, cyprodinil was</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:25057.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">negative up to a cytotoxic concentration (80 :g/mL) (MRID No. 43709035).</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;left:71.76pt;top:25344.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:25416.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">D.</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:25416.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">METABOLIC PROFILE</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:25452.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">Chemical Name/Code</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:377.00pt;top:25452.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">Chemical Structure</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:303pt;top:25447pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:303pt;top:25447pt;width: 1pt;height:19pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:25476.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">Cyprodinil (CGA-219417)</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:25527.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">4-cyclopropyl-6-methyl-N-phenyl-2-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:25539.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">pyrimidinamine</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:414.65pt;top:25515.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.48pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:430.90pt;top:25487.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.48pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:431.15pt;top:25544.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.48pt">CH</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:444.30pt;top:25550.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.23pt">3</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:398.40pt;top:25487.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.48pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:398.35pt;top:25479.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.48pt">H</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:25470pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:303pt;top:25470pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:536pt;top:25470pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:533pt;top:25470pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:303pt;top:25470pt;width: 1pt;height:109pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:25586.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">CGA-232449</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:25624.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">6-cyclopropyl-2-(phenylamino)-4-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:25636.95pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">pyrimidinemethanol</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:414.70pt;top:25625.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.15pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:430.90pt;top:25597.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.15pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:447.25pt;top:25663.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.15pt">OH</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:398.45pt;top:25597.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.15pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:398.35pt;top:25589.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.15pt">H</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:25579pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:25579pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:73pt;top:25579pt;width:229pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:303pt;top:25579pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:304pt;top:25579pt;width:229pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:536pt;top:25579pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:533pt;top:25579pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:303pt;top:25580pt;width: 1pt;height:110pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:25697.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">CGA-304075</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:25735.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">4-[(4-cyclopropyl-6-methyl-2-2-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:25748.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">pyrimidinyl)amino]-phenol</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:425.20pt;top:25730.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.99pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:439.20pt;top:25706.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.99pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:439.40pt;top:25755.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.99pt">CH</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:450.80pt;top:25760.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 5.18pt">3</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:411.20pt;top:25706.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.99pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:411.10pt;top:25699.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.99pt">H</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:354.90pt;top:25739.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.99pt">O</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:348.95pt;top:25739.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 7.99pt">H</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:25690pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:25690pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:73pt;top:25690pt;width:229pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:303pt;top:25690pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:304pt;top:25690pt;width:229pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:536pt;top:25690pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:533pt;top:25690pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:303pt;top:25691pt;width: 1pt;height:96pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:25794.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">CGA-304076</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:414.65pt;top:25834.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.49pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:430.90pt;top:25805.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.49pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:398.45pt;top:25805.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.49pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:398.30pt;top:25798.10pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.49pt">H</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:431.15pt;top:25862.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.49pt">CH</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:444.35pt;top:25868.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.24pt">3</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:463.55pt;top:25843.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.49pt">OH</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:25787pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:25787pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:73pt;top:25787pt;width:229pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:303pt;top:25787pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:304pt;top:25787pt;width:229pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:536pt;top:25787pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:533pt;top:25787pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:303pt;top:25788pt;width: 1pt;height:103pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:25899.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">NOA-413167</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:414.55pt;top:25941.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.52pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:430.85pt;top:25912.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.52pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:398.35pt;top:25912.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.52pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:398.20pt;top:25905.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.52pt">H</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:365.70pt;top:25893.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.52pt">OH</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:431.15pt;top:25969.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.52pt">CH</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:444.30pt;top:25975.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.28pt">3</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:25892pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:25892pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:73pt;top:25892pt;width:229pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:303pt;top:25892pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:304pt;top:25892pt;width:229pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:536pt;top:25892pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:533pt;top:25892pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:25999pt;width:233pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:303pt;top:25893pt;width: 1pt;height:106pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:304pt;top:25999pt;width:229pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:533pt;top:25999pt;width: 3pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:26050.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 33 of 38</FONT></FONT></FONT></SPAN>
<span style="color:#000000;background-color:#ffffff;position:absolute;left:0.00pt;top:25344.00pt;z-index:-1;"><img style="width:612pt;height:792pt;" src="outputfile-892646128.htm_files\outputfile-892646128_background32.png"></span>
<SPAN STYLE="position:absolute;left:71.76pt;top:26136.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:26842.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 34 of 38</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:26216.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">Chemical Name/Code</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:377.00pt;top:26216.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">Chemical Structure</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:303pt;top:26211pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:303pt;top:26211pt;width: 1pt;height:19pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:26240.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">CGA-249287</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:26278.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">4-cyclopropyl-6-methyl-2-pyrimidinamine</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:392.65pt;top:26284.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.22pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:410.45pt;top:26253.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.22pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:410.70pt;top:26315.40pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.22pt">CH</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:425.20pt;top:26322.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.65pt">3</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:374.80pt;top:26253.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.22pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:363.90pt;top:26253.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.22pt">H</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:371.40pt;top:26259.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.65pt">2</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:26234pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:303pt;top:26234pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:536pt;top:26234pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:533pt;top:26234pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:303pt;top:26234pt;width: 1pt;height:112pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:26353.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">NOA-422054</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:26391.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">4-cyclopropyl-6-hydroxymethyl-2-pyrimidinamine</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:392.60pt;top:26397.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.38pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:410.45pt;top:26366.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.38pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:428.40pt;top:26438.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.38pt">OH</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:374.90pt;top:26366.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.38pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:363.85pt;top:26366.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.38pt">H</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:371.35pt;top:26372.90pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.82pt">2</FONT></FONT></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:26346pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:70pt;top:26346pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:73pt;top:26346pt;width:229pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:303pt;top:26346pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:304pt;top:26346pt;width:229pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:536pt;top:26346pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:533pt;top:26346pt;width: 1pt;height: 1pt;background-color:#000000;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:303pt;top:26347pt;width: 1pt;height:120pt;background-color:#000000;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:26474.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">CGA-263208</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:75.10pt;top:26512.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.98pt">phenylguanidine</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:420.70pt;top:26477.35pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.19pt">N</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:420.65pt;top:26469.00pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.19pt">H</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:456.35pt;top:26477.25pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.19pt">NH</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:438.60pt;top:26508.05pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 10.19pt">NH</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:453.65pt;top:26514.70pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 6.54pt">2</FONT></FONT></FONT></SPAN>
<span style="position:absolute;font-size:0;left:72pt;top:26467pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:70pt;top:26467pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:73pt;top:26467pt;width:229pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:303pt;top:26467pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:304pt;top:26467pt;width:229pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:536pt;top:26467pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:533pt;top:26467pt;width: 1pt;height: 1pt;background-color:#000000;"></span><span style="position:absolute;font-size:0;left:303pt;top:26468pt;width: 1pt;height:96pt;background-color:#000000;"></span><span style="color:#000000;background-color:#ffffff;position:absolute;left:0.00pt;top:26136.00pt;z-index:-1;"><img style="width:612pt;height:792pt;" src="outputfile-892646128.htm_files\outputfile-892646128_background33.png"></span>
<SPAN STYLE="position:absolute;left:71.76pt;top:26928.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:27014.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">E.</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:108.00pt;top:27014.80pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">TOXICITY STUDY REFERENCES</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:202.00pt;top:27042.75pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">82-1       Subchronic Oral Toxicity: 90-Day Study</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:95.30pt;top:27060.25pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MRID</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:301.85pt;top:27060.25pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Citation Reference</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:27086pt;width:72pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:151pt;top:27086pt;width:388pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:27098.15pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709026</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:27098.15pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Frankhauser, H. (1991) CGA-219417 Technical: 3-Month Oral Toxicity Study in Rats</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27109.60pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(Administration in Food): Amended: Lab Project Number: 891321. Unpublished study</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27121.10pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">prepared by Ciba-Geigy Ltd. 436 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:27140.10pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709027</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:27140.10pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Frankhauser, H. (1991) CGA-219417 Technical: 3-Month Range Finding Toxicity Study</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27151.60pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">in Mice: (Final Report): Lab Project Number: 891320. Unpublished study prepared by</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27163.05pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Ciba-Geigy Ltd. 219 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:27182.05pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709028</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:27182.05pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Altmann, B. (1991) CGA-219417 Technical: 3-Month Subchronic Oral Toxicity Study in</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27193.55pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Beagle Dogs: Amended (Final Report): Lab Project Number: 891323. Unpublished study</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27205.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">prepared by Ciba-Geigy Ltd. 323 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:27224.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43737601</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:27224.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Frankhauser, H. (1991) CGA-219417 Technical: 28-Day Oral Cumulative Toxicity Study</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27235.50pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">in Rats: Amended (Final Report): Lab Project Number: 891322. Unpublished study</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27246.95pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">prepared by Ciba-Geigy Ltd. 264 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:27265.95pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43866301</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:27265.95pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Bachman, M. (1989) CGA-219417: 28-Days Range Finding Study in Rats:</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27277.45pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(Administration in Food): Lab Project Number: 891050. Unpublished study prepared by</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27288.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Ciba-Geigy Ltd. 263 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:27307.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">45614706</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:27307.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Altmann, B. (2002) 90-Day Oral Toxicity Study in Rat (Administration in Food): CA1139</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27319.40pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">A: Final Report: Lab Project Number: 20013024: 2692-01. Unpublished study prepared</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27330.85pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">by RCC Ltd. 599 p. {OPPTS 870.3100}</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:234.55pt;top:27346.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">82-2       21-day dermal-rabbit/rat</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:95.30pt;top:27363.95pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MRID</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:301.85pt;top:27363.95pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Citation Reference</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:27390pt;width:72pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:151pt;top:27390pt;width:388pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:27401.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709029</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:27401.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Hagemann, C. (1991) CGA-219417 Technical: 28-Day Repeated Dose Dermal Toxicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27413.35pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Study in the Rat: Amended (Final Report): Lab Project Number: 901078. Unpublished</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27424.80pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">study prepared by Ciba-Geigy Ltd. 230 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:233.40pt;top:27440.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">82-7       Subchronic Neurotoxicity</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:95.30pt;top:27458.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MRID</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:301.85pt;top:27458.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Citation Reference</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:27484pt;width:72pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:151pt;top:27484pt;width:388pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:27495.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">45906101</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:27495.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Classen, W. (1997) 90-Day Subchronic Neurotoxicity Study in Rats: Final Report: Lab</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27507.35pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Project Number: 963031. Unpublished study prepared by Novartis Crop Protection AG.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27518.85pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">367 p. {OPPTS 870.6200}</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:251.95pt;top:27534.50pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">83-1       Chronic Toxicity</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:95.30pt;top:27552.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MRID</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:301.85pt;top:27552.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Citation Reference</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:27578pt;width:72pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:151pt;top:27578pt;width:388pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:27589.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709030</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:27589.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Altmann, B. (1992) CGA-219417 Technical: 12-Month Chronic Dietary Toxicity Study in</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27601.40pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Beagle Dogs: Amended (Final Report): Lab Project Number: 891324. Unpublished study</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:27634.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 35 of 38</FONT></FONT></FONT></SPAN>
<span style="color:#000000;background-color:#ffffff;position:absolute;left:0.00pt;top:26928.00pt;z-index:-1;"><img style="width:612pt;height:792pt;" src="outputfile-892646128.htm_files\outputfile-892646128_background34.png"></span>
<SPAN STYLE="position:absolute;left:71.76pt;top:27720.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27796.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">prepared by Ciba-Geigy Ltd. 455 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:27815.05pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43737602</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:27815.05pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Frankhauser, H. (1994) CGA-219417 Technical: 24-Month Carcinogenicity and Chronic</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27826.50pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Toxicity Study in Rats: Lab Project Number: 891326. Unpublished study prepared by</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27837.95pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Ciba-Geigy Ltd. 1255 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:27857.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">44417902</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:27857.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Fankhauser, H. (1994) 24-Months Carcinogenicity and Chronic Toxicity Study in Rats:</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27868.45pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Cyprodinil Technical (CGA-219417): Addendum: Lab Project Number: 891326.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27879.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Unpublished study prepared by Novartis Crop Protection, Inc. 374 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:260.10pt;top:27895.60pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">83-2       Oncogenicity</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:95.30pt;top:27913.10pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MRID</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:301.85pt;top:27913.10pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Citation Reference</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:27939pt;width:72pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:151pt;top:27939pt;width:388pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:27951.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709031</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:27951.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Frankhauser, H. (1994) CGA-219417 Technical: 18-Month Carcinogenicity Study in</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27962.45pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Mice: Amended (Final Report): Lab Project Number: 891325. Unpublished study</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:27973.95pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">prepared by Ciba-Geigy Ltd. 828 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:27992.95pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43737602</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:27992.95pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Frankhauser, H. (1994) CGA-219417 Technical: 24-Month Carcinogenicity and Chronic</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28004.40pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Toxicity Study in Rats: Lab Project Number: 891326. Unpublished study prepared by</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28015.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Ciba-Geigy Ltd. 1255 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:28034.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">44417901</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:28034.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Fankhauser, H. (1994) 18-Month Carcinogenicity Study in Mice: Cyprodinil Technical</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28046.35pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(CGA-219417): Addendum: Lab Project Number: 891325. Unpublished study prepared</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28057.85pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">by Novartis Crop Protection, Inc. 348 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:28076.85pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">44417902</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:28076.85pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Fankhauser, H. (1994) 24-Months Carcinogenicity and Chronic Toxicity Study in Rats:</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28088.30pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Cyprodinil Technical (CGA-219417): Addendum: Lab Project Number: 891326.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28099.80pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Unpublished study prepared by Novartis Crop Protection, Inc. 374 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:231.95pt;top:28115.45pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">83-3       Teratogenicity -- 2 Species</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:95.30pt;top:28132.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MRID</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:301.85pt;top:28132.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Citation Reference</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:28159pt;width:72pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:151pt;top:28159pt;width:388pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:28170.85pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709032</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:28170.85pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Marty, J. (1991) CGA-219417 Technical: Developmental Toxicity Study in Rats:</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28182.30pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Amended (Final Report): Lab Project Number: 891327. Unpublished study prepared by</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28193.75pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Ciba-Geigy Ltd. 299 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:28212.80pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709033</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:28212.80pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Marty, J. (1991) CGA-219417 Technical: Developmental Toxicity (Teratogenicity Study</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28224.25pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">in Rabbits): Amended (Final Report): Lab Project Number: 891329. Unpublished study</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28235.70pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">prepared by Ciba-Geigy Ltd. 238 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:28254.75pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43886301</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:28254.75pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Marty, J. (1990) CGA-219417 Technical: Preliminary Oral Toxicity Study with CGA-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28266.20pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">219417 Technical in Pregnant Rabbits: (Dose Rangefinding Study): Lab Project</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28277.65pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Number: 891331. Unpublished study prepared by Ciba-Geigy Ltd. 25 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:28296.70pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">45614707</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:28296.70pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Khalil, S. (2002) Prenatal Developmental Toxicity Study in the Rat: CGA-263208</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28308.15pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Technical: Final Report: Lab Project Number: 20013025: 2693-01. Unpublished study</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28319.60pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">prepared by RCC Ltd. 474 p. {OPPTS 870.3700}</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:238.80pt;top:28335.30pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">83-4       2-generation repro.-rat</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:95.30pt;top:28352.75pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MRID</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:301.85pt;top:28352.75pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Citation Reference</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:28379pt;width:72pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:151pt;top:28379pt;width:388pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:28390.70pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709034</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:28390.70pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Khalil, S. (1993) CGA-219417 Technical: Two-Generation Reproduction Study in Rats:</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:28426.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 36 of 38</FONT></FONT></FONT></SPAN>
<span style="color:#000000;background-color:#ffffff;position:absolute;left:0.00pt;top:27720.00pt;z-index:-1;"><img style="width:612pt;height:792pt;" src="outputfile-892646128.htm_files\outputfile-892646128_background35.png"></span>
<SPAN STYLE="position:absolute;left:71.76pt;top:28512.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28588.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Amended (Final Report): Lab Project Number: 891328. Unpublished study prepared by</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28599.50pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Ciba-Geigy Ltd. 1409 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:163.55pt;top:28615.15pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">83-5       Dietary: Combined Chronic Toxicity/Oncogenicity Studies</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:95.30pt;top:28632.65pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MRID</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:301.85pt;top:28632.65pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Citation Reference</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:28659pt;width:72pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:151pt;top:28659pt;width:388pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:28670.60pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">44429401</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:28670.60pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Chow, E. (1997) Cyprodinil Technical: 24-Months Carcinogenicity and Chronic Toxicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28682.05pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Study in Rats: Supplement: Lab Project Number: CGA 219417: 891326. Unpublished</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28693.50pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">study prepared by Novartis Crop Protection, Inc. 86 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:222.05pt;top:28709.20pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">84-2       Interaction with Gonadal DNA</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:95.30pt;top:28726.70pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MRID</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:301.85pt;top:28726.70pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Citation Reference</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:28753pt;width:72pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:151pt;top:28753pt;width:388pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:28764.60pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709035</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:28764.60pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Geleick, D. (1991) CGA-219417 Technical: Authoradiographic (sic) DNA Repair Test on</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28776.05pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Rat Hepatocytes in vitro: Amended: Lab Project Number: 901083. Unpublished study</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28787.55pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">prepared by Ciba-Geigy Ltd. 101 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:28806.55pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709036</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:28806.55pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Geleick, D. (1990) CGA-219417 Technical: Gene Mutation Test with Chinese Hamster</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28818.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Cells V79: Amended: Lab Project Number: 901086. Unpublished study prepared by</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28829.50pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Ciba-Geigy Ltd. 51 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:28848.50pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709037</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:28848.50pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Ogorek, B. (1990) CGA-219417 Technical: Salmonella and Escerichia/Liver--Microsome</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28859.95pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Test: Amended: Lab Project Number: 901084. Unpublished study prepared by Ciba-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28871.45pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Geigy Ltd. 49 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:28890.45pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709038</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:28890.45pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Strasser, F. (1991) CGA-219417 Technical: Structural Chromosomal Aberration Test:</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28901.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Cytogenic Test on Chinese Hamster Cells in vitro: Amended: Lab Project Number:</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28913.40pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">901085. Unpublished study prepared by Ciba-Geigy Ltd. 43 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:28932.40pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709039</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:28932.40pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Ceresa, C. (1990) CGA-219417 Technical: Structural Chromosomal Aberration Test:</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28943.85pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Micronucleus Test, Mouse in vivo Study: Amended: Lab Project Number: 901082.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28955.35pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Unpublished study prepared by Ciba-Geigy Ltd. 45 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:28974.35pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">45353505</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:28974.35pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Hertner, T. (1992) Salmonella and Escherichia/Liver-Microsome Test: CGA-249287</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28985.80pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Technical: Final Report: Lab Project Number: 923089: 530-92. Unpublished study</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:28997.30pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">prepared by Novartis Crop Protection AG. 71 p. {OPPTS 870.5100}</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:29016.30pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">45353506</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:29016.30pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Hertner, T. (1994) Salmonella and Escherichia/Mammalian-Microsome Mutagenicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29027.75pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Test: CGA-263208 Technical: Final Report: Lab Project Number: 943052: 530-94.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29039.25pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Unpublished study prepared by Novartis Crop Protection AG. 72 p. {OPPTS 870.5100}</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:29058.25pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">45353507</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:29058.25pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Hertner, T. (1994) Salmonella and Escherichia/Mammalian-Microsome Mutagenicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29069.70pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Test: CGA-232449 Technical: Final Report: Lab Project Number: 943108: 531-94.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29081.20pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Unpublished study prepared by Novartis Crop Protection AG. 80 p. {OPPTS 870.5100}</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:29100.20pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">45353508</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:29100.20pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Deparade, E. (2000) Salmonella and Escherichia/Mammalian-Microsome Mutagenicity</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29111.70pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Test: NOA 422054 Technical: Final Report: Lab Project Number: 20003021: 946-00.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29123.15pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Unpublished study prepared by Novartis Crop Protection AG. 65 p. {OPPTS 870.5100}</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:245.05pt;top:29138.85pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">85-1       General metabolism</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:95.30pt;top:29156.20pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MRID</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:301.85pt;top:29156.20pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Citation Reference</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:29182pt;width:72pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:151pt;top:29182pt;width:388pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:29218.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 37 of 38</FONT></FONT></FONT></SPAN>
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<SPAN STYLE="position:absolute;left:71.76pt;top:29304.00pt"> </SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:29380.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709040</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:29380.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Thanei, P. (1992) Absorption, Distribution, Metabolism, and Excretion of (U-(carbon</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29391.50pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">14))Phenyl and (2-(carbon 14))Pyrimidyl CGA-219417 in the Rat: Lab Project Number:</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29402.95pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">08PT01: 08PT02: 08PT/03. Unpublished study prepared by Ciba-Geigy Ltd. 154 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:29421.95pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">43709041</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:29421.95pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Mueller, T. (1992) The Metabolism of (U-(carbon 14))Phenyl CGA-219417 and (2-</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29433.45pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">(carbon 14))Pyrimidyl CGA-219417 in the Rat: Lab Project Number: 13/92: 03TM01: PR</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29444.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">13/92. Unpublished study prepared by Ciba-Geigy Ltd. 68 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:29463.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">44867315</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:29463.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Allen, J.; East, P.; Francis, R. et al. (1975) Metabolism of Debrisoquine Sulfate:</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29475.40pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Identification of Some Urinary Metabolites in Rat and Man. Drug Metabolism and</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29486.85pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Disposition 3(5):332-337.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:220.45pt;top:29502.55pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">85-3       Dermal Penetration/Absorption</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:95.30pt;top:29520.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">MRID</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:301.85pt;top:29520.00pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><b><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Citation Reference</FONT></FONT></b></FONT></SPAN>
<SPAN STYLE="position:absolute;font-size:0;left:72pt;top:29546pt;width:72pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="position:absolute;font-size:0;left:151pt;top:29546pt;width:388pt;height: 1pt;background-color:#000066;"></SPAN><SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:29557.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">45906102</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:29557.90pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Mewes, K. (1999) Dermal Absorption of (Phenyl-U-(Carbon 14)) CGA 219417</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29569.40pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Formulated as Switch 62.5 WG (A-9219 B) in the Rat: Final Report: Lab Project</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29580.85pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Number: 028AM04. Unpublished study prepared by Novartis Crop Protection AG. 53 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29592.30pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">{OPPTS 870.7600}</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:72.00pt;top:29611.35pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">45906103</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.55pt;top:29611.35pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Mewes, K. (1999) The In Vitro Percutaneous Absorption of (Phenyl-U-(Carbon 14)) CGA</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29622.80pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">219417 Formulated as Switch 62.5 WG (A-9219 B) Through Rat and Human Epidermis:</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29634.25pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Final Report: Lab Project Number: 028AM05. Unpublished study prepared by Novartis</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:151.50pt;top:29645.75pt;z-index:3;"><FONT FACE ="Arial" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 9.96pt">Crop Protection AG. 47 p.</FONT></FONT></FONT></SPAN>
<SPAN STYLE="color:#000000;position:absolute;left:272.90pt;top:30010.65pt;z-index:3;"><FONT FACE ="Times New Roman" style = "font-size: 12.00pt"><FONT COLOR="000000"><FONT STYLE="font-size: 12.00pt">Page 38 of 38</FONT></FONT></FONT></SPAN>
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