Document ID: EPA-HQ-OPP-2011-0678-0003
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2011-09-30T04:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

 		WASHINGTON, D.C. 20460

August 9, 2011

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION

MEMORANDUM

SUBJECT:	Product Chemistry Scoping Document for the Registration Review
of Methyl Anthranilate.  

Registration Review Case #:		6070

PC Code:						128725  

CAS Numbers:					134-20-3

Chemical Class:					Biochemical

FROM:		Jacob Moore, Chemist /s/ 08/09/2011

Biochemical Pesticides Branch

Biopesticides & Pollution Prevention Division (7511P)

TO:			Chris Pfeifer, Regulatory Action Leader

Biochemical Pesticides Branch

Biopesticides & Pollution Prevention Division (7511P) 

ACTION REQUESTED

	A preliminary assessment of available information on product chemistry
data associated with the biopesticide methyl anthranilate and its
biochemical products in support of the development of a Registration
Review Work Plan.

Introduction

The EPA has made the determination that there is adequate information
available on methyl anthranilate and does not foresee the need to
require additional data from products currently registered that contain
methyl anthranilate as the active ingredient.  Methyl anthranilate is
used as a bird repellent of various sites including golf courses and
airports. Methyl anthranilate products have been registered with the EPA
since 1994. Having a sweet aromatic odor, methyl anthranilate is found
naturally in some grape varieties and is commonly used as a flavoring
agent. Currently there are 10 active registrations containing methyl
anthranilate, consisting of one technical grade active ingredient
registration, eight end-use or manufacturing-use products, and one
experimental use permit. The registered technical contains 98.5% methyl
anthranilate and related impurities. According to 40 CFR §180.1143, the
Agency exempts methyl anthranilate from the requirement of a tolerance
in or on all food commodities, when used in accordance with good
agricultural practices.

Concerning the product chemistry of methyl anthranilate, all biochemical
pesticide data requirements for the technical grade active ingredient
are summarized in Tables 1 and 2

Table 1. Product Identity and Composition for Methyl Anthranilate

 

Product Chemistry Summary

The Agency has conducted a review of the available product chemistry
data and information.  These data are summarized below.

Table 2. Biochemical Pesticides Product Chemistry Data Requirements for
Methyl Anthranilate.

830.7000	pH	N/A	N/A; pH testing done on end-use products.

830.7050	UV/Visible light absorption

λal = 248, 341 nm	A

	

830.7200	Melting point/melting range	A	24-25°C

830.7220	Boiling point/boiling range	A	256°C

830.7300	Density	A	1.168 g/mL

830.7520	Particle size, fiber length, and diameter distribution	N/A	N/A;
 water soluble

830.7550

830.7560

830.7840	Water solubility 	A	0.29 g/100mL

830.7950	Vapor pressure	A	0.012 mm (20°C)

A=Acceptable. N/A=Not Applicable.

References

C.Hansch, A. Leo and D. Hoekman, Exploring QSAR: hydrophobic, electronic
and steric constants, American Chemical Society, Washington (1995).

CRC Handbook of Chemistry and Physics. 80th ed. CRC Press: Boca Raton,
FL, 1979-9180; p. C-181.

EPA. Selected Mammal and Bird Repellents.
http://www.epa.gov/pesticides/biopesticides/ingredients/factsheets/facts
heet_mam-bird-repel.htm. 07/26/2011.

Merck Index, Online. 07/19/2011.

Primus, T.M., Griffin, D.L., Avery, M.L., Johnston, J.J. Liquid
Chromatographic Method for the Determination of Methyl Anthranilate in
Liquid Formulation and Residues on Formulated Rice See Bait. J. Agric.
Food Chem. 1995, 43(12),  pp 3052-3056.

PubChem.
http://pubchem.ncbi.nlm.nih.gov/summary/summary.chi?cid=6434508.
07/25/2011.

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6056

128725

Methyl Anthranilate			Case #:  6056

128725

Product Chemistry—Registration Review

  PAGE   \* MERGEFORMAT  3 

Taken from MRID 47941802

(Primus, 1995).

C.Hansch, A. Leo and D. Hoekman, Exploring QSAR: hydrophobic, electronic
and steric constants, 

 American Chemical Society, Washington (1995).