Document ID: EPA-HQ-OPP-2009-0004-0005
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2009-12-18T05:00Z

SEQ CHAPTER \h \r 1 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

                                         WASHINGTON, D.C.  20460

                                                                        
                                                                    
OFFICE OF              

PREVENTION, PESTICIDES

                                                                        
                                                                      
AND TOXIC SUBSTANCES 

MEMORANDUM

Date:  	8/13/2009

SUBJECT:  Rimsulfuron Chronic Aggregate Dietary (Food and Drinking
Water) Exposure and Risk Assessment for the Section 3 Registration on
Genetically Modified Soybeans and Field Corn

    

 

PC Code:  129009 	DP Barcode:  D365798

Decision No: 400402 	Registration No:  352-748 

Petition Nos.:  8F7431 and 8F7440	Regulatory Action:  Section 3
Registration 

Risk Assess Type:  None	Case No.:  None 

TXR No.:  None	CAS No.:  122931-48-0

MRID No.:   None 	40 CFR:  180.478

      	

FROM:  	Douglas Dotson, Ph.D., Chemist

	Risk Assessment Branch II, Health Effects Division (7509P)  SEQ CHAPTER
\h \r 1 		

		

THROUGH:	P. Yvonne Barnes, Chemist

		Nancy Dodd, Chemist

	Dietary Exposure Science Advisory Council

Health Effects Division (7509P)

		

TO:	Debra Rate, Ph.D., Biologist

Alternative Risk Integration and Assessment Team (ARIA)

Risk Integration, Minor Use, and Emergency Response Branch (RIMUERB)

Registration Division (7505P)

	

Executive Summary

A chronic aggregate dietary (food and drinking water) exposure and risk
assessment was conducted for the herbicide, rimsulfuron, using the
Dietary Exposure Evaluation Model, DEEM-FCID™, Version 2.03, which
uses food consumption data from the U.S. Department of Agriculture’s
Continuing Surveys of Food Intakes by Individuals (CSFII).  The surveys
were taken from 1994-1996 and included a supplemental children’s
survey taken in 1998.  The analysis was performed to support Section 3
registration on genetically modified soybeans and field corn. 
Rimsulfuron is already registered for use on field corn at the same
application rate as that proposed for use on genetically modified field
corn.  An acute dietary assessment was not performed, as a toxicological
endpoint attributable to a single dose has not been identified for
rimsulfuron.  Rimsulfuron is classified as “not likely” to be
carcinogenic; therefore, a cancer assessment was not performed.

 crops are treated.  DEEM™ Version 7.81 default processing factors
were applied to all processed commodities for which they were available.
 Drinking water was incorporated directly into the dietary assessment
using the estimated drinking water concentration (EDWC) for surface
water generated by the Tier 1 FQPA Index Reservoir Screening Tool
(FIRST) Model.

The resulting chronic dietary exposure estimates for food and water
combined are well below HED’s level of concern for the general U.S.
population and all population subgroups.  Using the DEEM-FCID software,
dietary exposure is estimated at 0.000428 mg/kg/day for the U.S.
population (<1% of the chronic population adjusted dose (cPAD)) and
0.001063 mg/kg/day (<1% of the cPAD) for children 1 to 2 years old, the
population subgroup with the highest estimated chronic dietary exposure
to rimsulfuron.  

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to the point of departure (PoD; e.g.
NOAEL, LOAEL, etc.) divided by the required uncertainty or safety
factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  References which
discuss the acute and chronic risk assessments in more detail are
available on the EPA/pesticides website:  “Available Information on
Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000,
web link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see
SOP 99.6 (20-AUG-1999).

II.	Residue Information

Residues of Concern:  The nature of the residue of rimsulfuron in plants
and livestock has been adequately delineated based on metabolism studies
conducted with rimsulfuron in field corn, potatoes, tomatoes, lactating
goats, and laying hens.  The metabolic pathways were found to be similar
in plants and livestock.  The major route of rimsulfuron
metabolism/degradation involves sulfonylurea bridge contraction, with
sulfonylurea bridge cleavage as a minor metabolic route.  Based on the
results of the studies, HED concluded that the residue of concern in
plant and livestock commodities is rimsulfuron only (Memo, D360852, D.
Rate, 8/13/2009, and MARC report, 2/11/98).

Tolerances:  Permanent tolerances have been established under 40 CFR
§180.478(a) for residues of rimsulfuron at 0.01 ppm for citrus fruit,
pome fruit, stone fruit, grapes, tree nuts, and pistachios; 0.05 ppm for
tomatoes, 0.09 ppm for almond hulls, and 0.1 ppm for potatoes and field
corn grain, forage, and stover.

DuPont Corporation has proposed tolerances for residues of rimsulfuron
in connection with uses on genetically modified soybeans and field corn.
 ARIA has reviewed residue data submitted to support these uses and
concluded that the tolerances given in Table 1 are appropriate (Memo, D.
Rate, D360852, 8/13/2009).  The existing 0.01 ppm tolerance on field
corn grain is adequate.  Soybean seed is the only human food item on
this list.

Table 1.  Rimsulfuron Recommended Tolerances

Crop Commodity	Recommended Tolerance (ppm)

Field Corn Forage	0.4

Field Corn Stover	2.5

Soybean Seed	0.01

Soybean Hay	1.2

Soybean Forage	0.25

Soybean Hulls	0.04

Aspirated Grain Fractions	4.5

Livestock:  Livestock feedstuffs associated with the proposed uses
include field corn grain, forage, silage, stover, and milled byproducts;
soybean seed, hay, forage, silage, and hulls; and aspirated grain
fractions (AGF).  Based on the metabolism studies and the dietary
burden, ARIA concluded that tolerances for livestock commodities are not
needed to support the proposed uses on soybeans and field corn.

EEM™ Version 7.81 default processing factors were applied to all
processed commodities for which they were available.  In the processing
study for soybean oil, residues did not concentrate.  Therefore, the
processing factor was left at 1.0.  

 Drinking Water Data

The drinking water residues used in the dietary risk assessment were
provided by the Environmental Fate and Effects Division (EFED, Memo, J.
Melendez, D358869, 1/23/2009).  Water residues were incorporated
directly into the DEEM-FCID assessment under the food categories
“water, direct, all sources” and “water, indirect, all sources.”
  

The residue of concern in drinking water is parent rimsulfuron only (HED
MARC decision memo; 03/29/1994).  EFED estimated residues of rimsulfuron
in surface water and groundwater using the FIRST and SCIGROW (Screening
Concentrations in Groundwater) models, respectively.  The models and
their descriptions are available at the EPA internet site:   HYPERLINK
"http://www.epa.gov/oppefed1/models/water/" 
http://www.epa.gov/oppefed1/models/water/ .  The maximum estimated
drinking water concentrations (EDWCs) are presented below in Table 2.

Table 2.  Maximum Rimsulfuron EDWCs in Surface and Ground Water

Maximum Surface Water EDWC (ppb)	Maximum Ground Water Acute/Chronic EDWC
(ppb)

Acute Value	Chronic/Cancer Value

	5.596	0.120	0.016

The chronic surface water EDWC was higher than the groundwater EDWC;
therefore, the surface water value of 0.120 ppb was used in the chronic
dietary assessment.  The acute surface water value is not relevant to
this dietary assessment, as a toxic effect attributable to a single dose
has not been identified for rimsulfuron.

™ Program and Consumption Information

A rimsulfuron chronic dietary exposure assessment was conducted using
the Dietary Exposure Evaluation Model software with the Food Commodity
Intake Database DEEM-FCID™, Version 2.03, which incorporates
consumption data from USDA’s Continuing Surveys of Food Intakes by
Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98 data are based
on the reported consumption of more than 20,000 individuals over two
non-consecutive survey days.  Foods “as consumed” (e.g., apple pie)
are linked to EPA-defined food commodities (e.g. apples, peeled fruit -
cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S,
baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA.  For chronic exposure assessment,
consumption data are averaged for the entire U.S. population and within
population subgroups, but for acute exposure assessment are retained as
individual consumption events.  Based on analysis of the 1994-96, 98
CSFII consumption data, which took into account dietary patterns and
survey respondents, HED concluded that it is most appropriate to report
risk for the following population subgroups: the general U.S.
population, all infants (<1 year old), children 1-2, children 3-5,
children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+
years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

V.	Toxicological Information

Reference:  Rimsulfuron – Updated Executive Summaries and Section 4.0
of Risk Assessment Document for Registration Action Branch 2., E. Rinde,
TXR Num. 0054356, 09/27/2006.

HED has evaluated the available toxicity data for rimsulfuron and
determined that the following endpoints and doses are appropriate for
use in the dietary risk assessment:

Table 3.  Summary of Toxicological Doses and Endpoints for Rimsulfuron
for Use in Human Dietary Risk Assessments

Exposure

Scenario	

Point of Departure/Uncertainty, FQPA Safety Factors	

RfD, PAD, Level of Concern	

Study and Toxicological Effects

Acute Dietary

(females 13-49)

Acute Dietary

(general population)	

None	

No appropriate endpoint attributable to a single dose is available.

Chronic Dietary

(all populations)

     	NOAEL=81.8 mg/kg/day

   

UFA = 10X

UFH  = 10X

FQPA SF = 1X

	

cPAD = 0.818 mg/kg/day	

Chronic Toxicity –Dog

LOAEL = 342.4 mg/kg/day, based on Increases in liver and kidney weights.

Cancer (oral, dermal, inhalation)	Classification: 

Rimsulfuron is classified as a “not likely “human carcinogen.

Point of Departure (PoD) = A data point or an estimated point that is
derived from observed dose-response data and  used to mark the beginning
of extrapolation to determine risk associated with lower environmentally
relevant human exposures.  NOAEL = no observed adverse effect level. 
LOAEL = lowest observed adverse effect level.  UF = uncertainty factor. 
UFA = extrapolation from animal to human (interspecies).  UFH =
potential variation in sensitivity among members of the human population
(intraspecies).  FQPA SF = FQPA Safety Factor.  PAD = population
adjusted dose (a = acute, c = chronic).  

The FQPA Safety Factor has been reduced to 1x for all population
subgroups, as there are no residual uncertainties, and there is no
evidence of increased pre- and/or post-natal susceptibility to
rimsulfuron.  There is no evidence of neurotoxicity in the database, and
a developmental neurotoxicity (DNT) study has not been required.

VI.	Results/Discussion 

FCID™ analyses estimate the dietary exposure of the U.S. population
and various population subgroups.  The results reported in Table 3 are
for the general U.S. Population, all infants (<1 year old), children
1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults
20-49, and adults 50+ years.  

Rimsulfuron chronic dietary (food + water) exposure estimates using the
DEEM-FCID™ software are well below HED’s level of concern for the
U.S. population and each of the population subgroups.  Dietary exposure
was estimated to be 0.000428 mg/kg/day for the U.S. population (<1% of
the cPAD) and 0.001063 mg/kg/day (<1% of the cPAD) for the most highly
exposed population subgroup (children, 1-2 years old).  The estimated
exposures and risks from residues of rimsulfuron in food and water are
summarized in Table 4.

Table 4.  Chronic Aggregate Dietary (Food + Drinking Water) Exposure and
Risk for Rimsulfuron

Population Subgroup	 Exposure

(mg/kg/day)	% cPAD

General U.S. Population	0.000428	<1

All Infants (< 1 year old)	0.000544	<1

Children 1-2 years old	0.001063	<1

Children 3-5 years old	0.001002	<1

Children 6-12 years old	0.000686	<1

Youth 13-19 years old	0.000504	<1

Adults 20-49 years old	0.000342	<1

Adults 50+ years old	0.000254	<1

Females 13-49 years old	0.000336	<1

1The population subgroup with the highest estimated chronic dietary
(food + drinking water) exposure and risk is indicated by bold text.

VII.	Characterization of Inputs/Outputs

These chronic dietary exposure and risk estimates are highly
conservative.  They are based on the assumption that 100% of crops with
tolerances are treated with rimsulfuron, and that residues in foods
“as eaten” are present at tolerance levels.  In addition, drinking
water exposure estimates are screening level estimates generated by the
Tier 1 FIRST Model.  

Dietary exposure estimates could be refined through the use of
anticipated residues, percent crop treated data, and/or refined
estimated drinking water concentrations.  However, as estimated
exposures and risks using conservative assumptions are well below
HED’s level of concern, such refinement is not warranted.

VIII.	Conclusions

This unrefined chronic dietary exposure analysis using DEEM-FCID™
indicates that chronic dietary exposure to rimsulfuron from food and
drinking water is well below HED’s level of concern for this
pesticide.  Estimated chronic dietary exposures are less than 1% of the
cPAD for the general U.S. population and all population subgroups.

IX.		List of Attachments

1.  Rimsulfuron Chronic Dietary Residue Input File 

2.  Results of Rimsulfuron Chronic Dietary Exposure Analysis

Attachment 1:  Rimsulfuron Chronic Dietary Residue Input File

Chronic NOAEL: 81.8 mg/kg bw/day

Chronic PAD (cPAD):  0.818 mg/kg bw/day

DEEM FCID (Version 2.03)

1994-1996 data and 1998 Supplemental Children’s Survey

Filename: C:\Documents and Settings\ddotson\My
Documents\Deemfcid\Rimsulfuron\Rimsulfuron Chronic.R98

Date created/last modified: 07-31-2009/10:16:32/8          

------------------------------------------------------------------------
-----

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------

01032960 1C   Potato, chips                      0.100000   1.000  1.000
 

01032970 1C   Potato, dry (granules/ flakes)     0.100000   6.500  1.000
 

01032971 1C   Potato, dry (granules/ flakes)-b   0.100000   6.500  1.000
 

01032980 1C   Potato, flour                      0.100000   6.500  1.000
 

01032981 1C   Potato, flour-babyfood             0.100000   6.500  1.000
 

01032990 1C   Potato, tuber, w/peel              0.100000   1.000  1.000
 

01032991 1C   Potato, tuber, w/peel-babyfood     0.100000   1.000  1.000
 

01033000 1C   Potato, tuber, w/o peel            0.100000   1.000  1.000
 

01033001 1C   Potato, tuber, w/o peel-babyfood   0.100000   1.000  1.000
 

06003470 6    Soybean, seed                      0.010000   1.000  1.000
 

06003480 6    Soybean, flour                     0.010000   1.000  1.000
 

06003481 6    Soybean, flour-babyfood            0.010000   1.000  1.000
 

06003490 6    Soybean, soy milk                  0.010000   1.000  1.000
 

06003491 6    Soybean, soy milk-babyfood or in   0.010000   1.000  1.000
 

06003500 6    Soybean, oil                       0.010000   1.000  1.000
 

06003501 6    Soybean, oil-babyfood              0.010000   1.000  1.000
 

08003740 8    Tomatillo                          0.050000   1.000  1.000
 

08003750 8    Tomato                             0.050000   1.000  1.000
 

08003751 8    Tomato-babyfood                    0.050000   1.000  1.000
 

08003760 8    Tomato, paste                      0.050000   5.400  1.000
 

08003761 8    Tomato, paste-babyfood             0.050000   5.400  1.000
 

08003770 8    Tomato, puree                      0.050000   3.300  1.000
 

08003771 8    Tomato, puree-babyfood             0.050000   3.300  1.000
 

08003780 8    Tomato, dried                      0.050000  14.300  1.000
 

08003781 8    Tomato, dried-babyfood             0.050000  14.300  1.000
 

08003790 8    Tomato, juice                      0.050000   1.500  1.000
 

10001060 10   Citrus citron                      0.010000   1.000  1.000
 

10001070 10   Citrus hybrids                     0.010000   1.000  1.000
 

10001080 10   Citrus, oil                        0.010000   1.000  1.000
 

10001800 10   Grapefruit                         0.010000   1.000  1.000
 

10001810 10   Grapefruit, juice                  0.010000   2.100  1.000
 

10001970 10   Kumquat                            0.010000   1.000  1.000
 

10001990 10   Lemon                              0.010000   1.000  1.000
 

10002000 10   Lemon, juice                       0.010000   2.000  1.000
 

10002001 10   Lemon, juice-babyfood              0.010000   2.000  1.000
 

10002010 10   Lemon, peel                        0.010000   1.000  1.000
 

10002060 10   Lime                               0.010000   1.000  1.000
 

10002070 10   Lime, juice                        0.010000   2.000  1.000
 

10002071 10   Lime, juice-babyfood               0.010000   2.000  1.000
 

10002400 10   Orange                             0.010000   1.000  1.000
 

10002410 10   Orange, juice                      0.010000   1.800  1.000
 

10002411 10   Orange, juice-babyfood             0.010000   1.800  1.000
 

10002420 10   Orange, peel                       0.010000   1.000  1.000
 

10003070 10   Pummelo                            0.010000   1.000  1.000
 

10003690 10   Tangerine                          0.010000   1.000  1.000
 

10003700 10   Tangerine, juice                   0.010000   2.300  1.000
 

11000070 11   Apple, fruit with peel             0.010000   1.000  1.000
 

11000080 11   Apple, peeled fruit                0.010000   1.000  1.000
 

11000081 11   Apple, peeled fruit-babyfood       0.010000   1.000  1.000
 

11000090 11   Apple, dried                       0.010000   8.000  1.000
 

11000091 11   Apple, dried-babyfood              0.010000   8.000  1.000
 

11000100 11   Apple, juice                       0.010000   1.300  1.000
 

11000101 11   Apple, juice-babyfood              0.010000   1.300  1.000
 

11000110 11   Apple, sauce                       0.010000   1.000  1.000
 

11000111 11   Apple, sauce-babyfood              0.010000   1.000  1.000
 

11001290 11   Crabapple                          0.010000   1.000  1.000
 

11002100 11   Loquat                             0.010000   1.000  1.000
 

11002660 11   Pear                               0.010000   1.000  1.000
 

11002661 11   Pear-babyfood                      0.010000   1.000  1.000
 

11002670 11   Pear, dried                        0.010000   6.250  1.000
 

11002680 11   Pear, juice                        0.010000   1.000  1.000
 

11002681 11   Pear, juice-babyfood               0.010000   1.000  1.000
 

11003100 11   Quince                             0.010000   1.000  1.000
 

12000120 12   Apricot                            0.010000   1.000  1.000
 

12000121 12   Apricot-babyfood                   0.010000   1.000  1.000
 

12000130 12   Apricot, dried                     0.010000   6.000  1.000
 

12000140 12   Apricot, juice                     0.010000   1.000  1.000
 

12000141 12   Apricot, juice-babyfood            0.010000   1.000  1.000
 

12000900 12   Cherry                             0.010000   1.000  1.000
 

12000901 12   Cherry-babyfood                    0.010000   1.000  1.000
 

12000910 12   Cherry, juice                      0.010000   1.500  1.000
 

12000911 12   Cherry, juice-babyfood             0.010000   1.500  1.000
 

12002300 12   Nectarine                          0.010000   1.000  1.000
 

12002600 12   Peach                              0.010000   1.000  1.000
 

12002601 12   Peach-babyfood                     0.010000   1.000  1.000
 

12002610 12   Peach, dried                       0.010000   7.000  1.000
 

12002611 12   Peach, dried-babyfood              0.010000   7.000  1.000
 

12002620 12   Peach, juice                       0.010000   1.000  1.000
 

12002621 12   Peach, juice-babyfood              0.010000   1.000  1.000
 

12002850 12   Plum                               0.010000   1.000  1.000
 

12002851 12   Plum-babyfood                      0.010000   1.000  1.000
 

12002860 12   Plum, prune, fresh                 0.010000   1.000  1.000
 

12002861 12   Plum, prune, fresh-babyfood        0.010000   1.000  1.000
 

12002870 12   Plum, prune, dried                 0.010000   5.000  1.000
 

12002871 12   Plum, prune, dried-babyfood        0.010000   5.000  1.000
 

12002880 12   Plum, prune, juice                 0.010000   1.400  1.000
 

12002881 12   Plum, prune, juice-babyfood        0.010000   1.400  1.000
 

14000030 14   Almond                             0.010000   1.000  1.000
 

14000031 14   Almond-babyfood                    0.010000   1.000  1.000
 

14000040 14   Almond, oil                        0.010000   1.000  1.000
 

14000041 14   Almond, oil-babyfood               0.010000   1.000  1.000
 

14000590 14   Brazil nut                         0.010000   1.000  1.000
 

14000680 14   Butternut                          0.010000   1.000  1.000
 

14000810 14   Cashew                             0.010000   1.000  1.000
 

14000920 14   Chestnut                           0.010000   1.000  1.000
 

14001550 14   Filbert                            0.010000   1.000  1.000
 

14001560 14   Filbert, oil                       0.010000   1.000  1.000
 

14001850 14   Hickory nut                        0.010000   1.000  1.000
 

14002130 14   Macadamia nut                      0.010000   1.000  1.000
 

14002690 14   Pecan                              0.010000   1.000  1.000
 

14002820 14   Pistachio                          0.010000   1.000  1.000
 

14003910 14   Walnut                             0.010000   1.000  1.000
 

15001200 15   Corn, field, flour                 0.100000   1.000  1.000
 

15001201 15   Corn, field, flour-babyfood        0.100000   1.000  1.000
 

15001210 15   Corn, field, meal                  0.100000   1.000  1.000
 

15001211 15   Corn, field, meal-babyfood         0.100000   1.000  1.000
 

15001220 15   Corn, field, bran                  0.100000   1.000  1.000
 

15001230 15   Corn, field, starch                0.100000   1.000  1.000
 

15001231 15   Corn, field, starch-babyfood       0.100000   1.000  1.000
 

15001240 15   Corn, field, syrup                 0.100000   1.500  1.000
 

15001241 15   Corn, field, syrup-babyfood        0.100000   1.500  1.000
 

15001250 15   Corn, field, oil                   0.100000   1.000  1.000
 

15001251 15   Corn, field, oil-babyfood          0.100000   1.000  1.000
 

86010000 O    Water, direct, all sources         0.000120   1.000  1.000
 

86020000 O    Water, indirect, all sources       0.000120   1.000  1.000
 

95001750 O    Grape                              0.010000   1.000  1.000
 

95001760 O    Grape, juice                       0.010000   1.200  1.000
 

95001761 O    Grape, juice-babyfood              0.010000   1.200  1.000
 

95001770 O    Grape, leaves                      0.010000   1.000  1.000
 

95001780 O    Grape, raisin                      0.010000   4.300  1.000
 

95001790 O    Grape, wine and sherry             0.010000   1.000 
1.000Attachment 2:  Results of Rimsulfuron Chronic Dietary Exposure
Analysis

Chronic NOAEL: 81.8 mg/kg bw/day

Chronic PAD (cPAD):  0.818 mg/kg bw/day

Adjustment factor #2 NOT used.

Residue file name: C:\Documents and Settings\ddotson\My
Documents\Deemfcid\Rimsulfuron\Rimsulfuron Chronic.R98

Analysis Date 07-31-2009/10:54:41     Residue file dated:
07-31-2009/10:16:32/8

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.000428                
0.1%

U.S. Population (spring season)             0.000429                
0.1%

U.S. Population (summer season)             0.000433                
0.1%

U.S. Population (autumn season)             0.000423                
0.1%

U.S. Population (winter season)             0.000426                
0.1%

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                        0.000493                 0.1%

Non-hispanic whites                         0.000417                
0.1%

Non-hispanic blacks                         0.000446                
0.1%

Non-hisp/non-white/non-black                0.000400                
0.0%

All infants (< 1 year)                      0.000544                
0.1%

Nursing infants                             0.000194                
0.0%

Non-nursing infants                         0.000676                
0.1%

Children 1-6  yrs                           0.000997                
0.1%

Children 7-12 yrs                           0.000656                
0.1%

Females 13-19 (not preg or nursing)         0.000452                
0.1%

Females 20+ (not preg or nursing)           0.000284                
0.0%

Females 13-50 yrs                           0.000362                
0.0%

Females 13+ (preg/not nursing)              0.000347                
0.0%

Females 13+ (nursing)                       0.000335                
0.0%

Males 13-19 yrs                             0.000556                
0.1%

Males 20+ yrs                               0.000337                
0.0%

Seniors 55+                                 0.000249                
0.0%

Children 1-2 yrs                            0.001063                
0.1%

Children 3-5 yrs                            0.001002                
0.1%

Children 6-12 yrs                           0.000686                
0.1%

Youth 13-19 yrs                             0.000504                
0.1%

Adults 20-49 yrs                            0.000342                
0.0%

Adults 50+ yrs                              0.000254                
0.0%

Females 13-49 yrs                           0.000336                
0.0%

------------------------------------------------------------------------
-------

Rimsulfuron                                       Dietary Exposure and
Risk Assessment                           DP Number: 365798

PC Code:  129009                 		

________________________________________________________________________
____________________

Page   PAGE  11  of   NUMPAGES  11