Document ID: EPA-HQ-OPP-2010-0588-0020
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2011-02-11T05:00Z

February 11, 2011

E-Docket Availability of Attachments A-H (Revised)

The central background document for the February 15-18, 2011 FIFRA SAP meeting is entitled, "Source-to-Outcome Modeling Physiologically-Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model linked to a Dietary Exposure Model: Chlorpyrifos as a Case Study." This document refers to eight supporting attachments "A" to "H." A listing of the contents for each attachment appears below, along with any explanatory notes.
 
1.	Attachment A: In vitro human metabolism summary of Smith et al., an unpublished manuscript (1 page).  
2.	Attachment B: Philpott, P. (2009) "June 24-25, 2009 EPA Human Studies Review Board Meeting Report." Memo and final report (40 pages).  
3.	Attachment C: The LifeStage and Variation models: acslX programs and associated m files.  
4.	Attachment D: Cleveland, C.B. (2010) "2010 Update of the Acute Dietary Risk Assessment for Chlorpyrifos."  Dow AgroSciences Unpublished Report 101760 (140 pages).  
5.	Attachment E1: Copies of inputs files used in dietary models (CARES, DEEM, LIFELINE).
6.	Attachment F1: Copies of input files for PBPK/PD model runs.
7.	Attachment G: Marty, M.S. and Andrus, A.K. (2010) "Comparison of Cholinesterase (ChE) Inhibition in Young Adult and Preweanling CD Rats after Acute and Repeated Chlorpyrifos or Chlorpyrifos-oxon Exposures."  Dow AgroSciences Unpublished Report 091107.  Public release summary (7 pages).
8.	Attachment H2: Reiss, R.; Neal, B.; Lamb, J. (2010) "Benchmark Dose Modeling for Cholinesterase Inhibition from Exposure to Chlorpyrifos and Chlorpyrifos-Oxon."  Dow AgroSciences Unpublished Report 0900956.000 B0T0 06010.  Public release summary (4 pages).