Document ID: EPA-HQ-OPP-2008-0270-0005
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2009-05-26T04:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF           

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM			

March 3, 2009									

SUBJECT:	Acibenzolar-S-Methyl – Revised Acute and Chronic Dietary and
Drinking Water Exposure and Risk Assessments  

PC Code:  061402	DP Barcode: 362208

Decision No.:  393110	Registration No.: 100-922

Petition No.:  PP#8F7352, PP8E7337	Regulatory Action:  Section 3 

Risk Assessment Type:  Dietary	Case No.:  NA

TXR No.:  NA	CAS No.:  135158-54-2

MRID No.:  NA	40 CFR:  180.561

FROM:	Becky Daiss, Biologist

Risk Assessment Branch IV

Health Effects Division (7509P)

THROUGH:	Thurston Morton and Anant Parmar

Dietary Exposure Science Advisory Council (DESAC), 

Health Effects Division (7509P)

TO:		Tony Kish, Product Manager

		Fungicide Branch

		Susan Stanton, Product Manager

		RIMUER Branch

Registration Division (7505P)

This document provides a revised acute and chronic dietary and drinking
water risk analyses of exposures resulting from use of
acibenzolar-S-methyl as a plant activator on food crops.  This
assessment supports a Section 3 requests for use of acibenzolar-S-methyl
on cucurbit vegetables and bulb onions.  Executive Summary

Acute and chronic dietary risk assessments were conducted for
acibenzolar-S-methyl using the Dietary Exposure Evaluation Model
(DEEM-FCID, Version 2.03), which uses food consumption data from the
USDA’s Continuing Surveys of Food Intakes by Individuals (CSFII) from
1994-1996 and 1998.  The analyses were performed to support Section 3
requests for use of acibenzolar-S-methyl on cucurbit vegetables and bulb
onions.

   

Acute Dietary Exposure Results and Characterization

A refined (probabilistic) acute dietary exposure analysis was performed
for the population subgroup females 13-49 only.  No acute endpoint was
identified for the remaining population subgroups.  The acute analysis
assumed a distribution of residues based on field trial data.  DEEM
default and empirical processing factors were used to modify the field
trial data.  Maximum screening-level percent crop treated estimates were
used for commodities for which data were available.  If no percent crop
treated data were available, 100% crop treated was assumed.  The acute
analysis incorporated the 1 in 10 year peak surface drinking water
estimate from application of acibenzolar-S-methyl to cucurbit
vegetables.    SEQ CHAPTER \h \r 1 The resulting 99.9th percentile acute
exposure estimate for females 13-49 years old is not of concern to HED
(12% acute population adjusted dose (aPAD)).    

Chronic Dietary Exposure Results and Characterization

A conservative chronic dietary exposure analysis was performed for the
general U.S. population and various population subgroups.  Tolerance
level residues and 100 crop treated assumptions were used.  DEEM default
and empirical processing factors were used to modify the tolerance
values.  The chronic analysis incorporated the 10 year average surface
drinking water estimate from application of acibenzolar-S-methyl to
cucurbit vegetables.  The population subgroup females 13-49 had a more
protective chronic population adjusted dose (cPAD, 0.082 mg/kg/day) than
the general U.S. population and all other population subgroups (0.25
mg/kg/day).  Chronic dietary risk estimates are not of concern for
general population or other population subgroups.  The subgroup with the
highest risk estimate was females 13-49 with a cPAD of 5%.  The cPAD for
the general U.S. population was 2%. 

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to the Reference Dose (RfD) divided by the
FQPA Safety Factor.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  References that discuss
the acute and chronic risk assessments in more detail are available on
the EPA/pesticides web site:  “Available Information on Assessing
Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link:   
HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA_PEST/2000/July/Day_12/6061.pdf  ; or see
SOP 99.6 (8/20/99).

II.	Residue Information

Residues of Concern 

The HED Metabolism Assessment Review Committee (MARC) reviewed lettuce,
tomato, cotton, lemon, poultry, and ruminant metabolism studies and the
environmental fate data.  Table 1 provides a summary of the MARC
decisions regarding residues of concern for acibenzolar-S-methyl. 
(D261037, M. Doherty, 4/26/00)

Table 1:  Summary of MARC Decisions for Acibenzolar-S-methyl 

Matrix	Residues of Concern 1

	For Risk Assessment 2	For Tolerance Expression

Plants	Residues of acibenzolar-S-methyl, benzo(1,2,3)
thiadiazole-7-carbothioic acid-S-methyl ester, convertible to
benzo(1,2,3)thiadiazole-7-carboxylic acid (CGA-210007), expressed as
acibenzolar-S-methyl &

4-hydroxy CGA-210007 (CGA-323060)

5-hydroxy CGA-210007 (CGA-324041)	Residues of acibenzolar-S-methyl,
benzo(1,2,3) thiadiazole-7-carbothioic acid-S-methyl ester, convertible
to benzo(1,2,3)thiadiazole-7-carboxylic acid (CGA-210007), expressed as
acibenzolar-S-methyl 

1 The residues of concern for drinking water are the same as those
listed in the tolerance expression

2 If a future petition is received for rice, residues of CGA-379019
should be included in the risk assessment

Established/Recommended Tolerances

Tolerances have been established (40CFR 180.561) for residues of
acibenzolar-S- methyl (benzo(1,2,3)thiadiazole-7-carbothioic
acid-S-methyl ester) in/on spinach at 1.0 ppm, leafy vegetables (Crop
Group 4, other than spinach, at 0.25 ppm), Brassica (cole) leafy
vegetables (Crop Group 5 at 1.0 ppm), fruiting vegetables (Crop Group 8
at 1.0 ppm), and tomato paste at 3.0 ppm.  There is also an import
tolerance for bananas at 0.1 ppm.  Tolerances have been proposed for the
bulb onion subgroup 3-07A and the curcurbit vegetable crop group 9.  
Tolerances have been established and/or recommended for individual crop
groups based on field trial data for representative commodities in
accordance with HED SOP 2000.1 (9/12/2000).  Recommended tolerances for
the proposed new uses are as follows.  

Onion, bulb, subgroup 3-07A 	0.1 ppm

Vegetable, cucurbit, group 9 	2.0 ppm

The tolerance expression for acibenzolar-S-methyl is for residues
convertible to benzo(1,2,3)thiadiazole-7-carboxylic acid (CGA-210007),
expressed as acibenzolar-S-methyl.  

Residues Used in the Chronic Analysis

In the chronic dietary exposure analysis, tolerance level residues were
used and 100 percent crop treated was assumed for all commodities.  DEEM
default processing factors were used for dried onion, dried banana,
dried plantain, and dried tomato.  A processing factor was not used for
tomato paste because a separate tolerance has been established for this
processed commodity.  In the submitted tomato processing study (D246673,
M. Doherty, 3/15/2000), reported processing factors of 1.0 and 2.9 for
tomato juice and tomato puree were used.    

Available lettuce metabolism data for a 7-day PHI were used to determine
the relative abundance of the hydroxy metabolites (CGA-323060 and
CGA-324041) and residues convertible to the carboxylic acid metabolite
(CGA-210007).  Based on the lettuce metabolism data, a factor of 1.5x
was applied to estimates of acibenzolar-S-methyl residues to account for
all of the residues of concern for dietary risk (including CGA-210007,
CGA-323060 and CGA-324041).  Lettuce metabolism data are provided in
Table 2.  

Table 2.  Lettuce metabolism data (Washed, 7-day PHI)

Compound	% Residues

Acibenzolar-S-Methyl	17

CGA-210007	25

CGA-323060	20

CGA-324041	0.06

 

Residues Used in the Acute Analysis

A probabilistic assessment was performed for the acute analysis.  The
acute analysis assumed a distribution of residues based on field trial
data for nonblended and partially blended commodities.  For blended
commodities, the mean field trial values were used as a point estimate.
A value of ½ LOQ was used for samples that contained less than LOQ
residues.  Foods were classified as blended, partially blended, or
nonblended based on guidance given in the Draft DEEM-FCID Classification
of Food Forms with Respect to Blending (F. Fort, 4/9/2003).  DEEM
default processing factors were used for dried onion, dried banana,
dried plantain, and dried tomato.  Empirical processing factors were
used for tomato paste (7.1), tomato puree (2.9), and tomato juice (1.0).
 The acute analysis used available maximum percent crop treated
estimates from the Biological and Economic Analysis Division’s
(BEAD’s) screening-level analysis (D353541, J. Alsadek, 6/18/08).  If
no percent crop treated data were available 100% crop treated was
assumed.  As previously noted, a factor of 1.5X was applied to the
estimate of residues convertible to CGA-210007 for all commodities to
account for all of the residues of concern for dietary risk.  

Residues used in the acute and chronic dietary analyses are provided in
Table 3.



Table 3.  Data and Residue Estimates Used in Acibenzolar-S-Methyl
Dietary and Drinking Water Analyses

Commodity	Blended

Status 1

	Data

Source	%CT	Process

Factors	Anticipated Residue Estimates/Tolerance 2

	Avg	Max

Acute	Chronic

(Tolerance)

Crop Group 3-07A Onions

Onion, dry bulb and

dry bulb-babyfood	NB/PB	Field Trials

14 samples

1 detectable residue MRID47375301

	100	100	NA	RDF# 23

Onion (100% CT)

TOTALZ=0

TOTALNZ=7	1.0

Onion , dry bulb dried, and dried-babyfood	B

9	Tolerance 1.0

	Onion , Green Onion

	NA

Crop Group 4A – Leafy Greens

Amaranth, Arugula, Cress Chrysanthemum , Endive, Dandelions, Parsley	PB
Field Trails

11 samples

11 detectable residues

MRID 44537062	100	100	NA	RDF# 18

SpinichOth (100% CT)

TOTALZ=0

TOTALNZ=11	0.25

Lettuce, head               	NB/PB	Field Trails

12 samples

12 detectable residues

MRID 44537062	8	12	NA	RDF# 6

LettuceH (12% CT)

TOTALZ=88

TOTALNZ=12	0.25

Lettuce, leaf                      	PB	Field Trails

11 samples

11 detectable residues

MRID 44537062	8	12	NA	RDF# 8

LettuceL (12% CT)

TOTALZ=81

TOTALNZ=11	0.25

Radicchio	PB	Field Trails

12 samples

12 detectable residues

MRID 44537062	100	100	NA	RDF# 16

LettuceHRad(12% CT)

TOTALZ=0

TOTALNZ=12	0.25

Spinach	PB	Field Trails

11 samples

11 detectable residues

MRID 44537062	15	30	NA	RDF# 10

Spinach (30% CT)

TOTALZ=26

TOTALNZ=11	1.0

Crop Group 4B – Leafy Petioles

Cardoon 

Celtuce 

Fennel 

Rhubarb 

Swiss chard	NB	Field Trails

9 samples

9detectable residues

MRID 44537062	100	100	NA	RDF# 15

CeleryOth (100% CT)

TOTALZ=0

TOTALNZ=9	0.25

Celery	NB/PB	Field Trails

9 samples

9detectable residues

MRID 44828007	1	1	NA	RDF# 15

Celery (1% CT)

TOTALZ=0

TOTALNZ=9	0.25

Crop Group 5A – Brassica Head & Stem

Broccoli

Cauliflower 	NB/PB	Field Trails

11 samples

11detectable residues

MRID 44828007	5	5	NA	RDF# 3

Broccoli (5% CT)

TOTALZ=209

TOTALNZ=11	1.0

Cabbage	NB/PB	Field Trails

11 samples

11detectable residues

MRID 44828007	2.5	1	NA	RDF# 4

Cabbage (2.5% CT)

TOTALZ=429

TOTALNZ=11	1.0

Cabbage Chinese Mustard

Brocolli Chinese	NB	Field Trails

11 samples

11detectable residues

MRID 44828007	100	100	NA	RDF# 13

BroccoliOth (100% CT)

TOTALZ=0

TOTALNZ=11	1.0

Kohlrabi

Brussels sprouts

Cabbage Chinese Napa	NB	Field Trails

11 samples

11detectable residues

MRID 44828007	100	100	NA	RDF# 14

CabbageOth (100% CT)

TOTALZ=0

TOTALNZ=11	1.0

Crop Group 5B– Brassica Leafy Greens

Cabbage Chinese bok choy      

Collards

Kale

Mustard Greens

Rape greens 

Turnip greens    	NB	Field Trails

9 samples

9detectable residues

MRID 44828007	100	100	NA	RDF# 9

Mustard (100% CT)

TOTALZ=0

TOTALNZ=9	1.0

Crop Group 8 – Fruiting Vegetables

Eggplant,  	NB/PB	Field Trails

9 samples

9detectable residues

MRID 44537060	100	100	NA	RDF# 12

BellPepOth (100% CT)

TOTALZ=0

TOTALNZ=9	1.0

Okra	NB/PB	Field Trails

9 samples

9detectable residues

MRID 44537060	100	100	NA	RDF# 17

HotPepOth (100% CT)

TOTALZ=0

TOTALNZ=9	1.0

Pepper nonbell   	NB/PB	Field Trails

5 samples

5 detectable residues

MRID 44537060	5	5	NA	RDF# 7

HotPep (5% CT)

TOTALZ=95

TOTALNZ=5	1.0	5

Pepper nonbell , dried	B	Field Trails

5 samples

5 detectable residues

MRID 44537060	5	5	NA	Mean field trial (0.321)	1.0

	Pepper, bell  	NB/PB	Field Trails

9 samples

9detectable residues

MRID 44537060	5	5	NA	RDF# 2

BellPep (5% CT)

TOTALZ=179

TOTALNZ=9	1.0	5

Tomatillo	NB/PB	Field Trails

23 samples

23detectable residues

MRID 44537060	100	100	NA	RDF# 19

TomatoOth(100% CT)

TOTALZ=0

TOTALNZ=23	1.0

Tomato	NB/PB	Field Trails

23 samples

23detectable residues

MRID 44537060	5	5	NA	RDF# 11

Tomato(5% CT)

TOTALZ=437

TOTALNZ=23	1.0

Tomato, paste, 	B	Field Trails

23 samples

23detectable residues

MRID 44537060	5	5	7.1	Mean field trial: 0.164	1.0

Tomato, puree  	B	Field Trails

23 samples

23detectable residues

MRID 44537060	5	5	2.9	Mean field trial: 0.164	1.0

Tomato, dried                      	B	Field Trails

23 samples

23detectable residues

MRID 44537060	5	5	14.3	Mean field trial: 0.164	1.0

Crop Group 9A– Cucurbit Vegetables - Melon

Cantaloupe, 

Casaba, 

Honeydew melon, 

Watermelon                     	NB/PB	Field Trails

12samples

12detectable residues

MRID 45105301	100	100	NA	RDF# 20

Cantaloupe(100% CT)

TOTALZ=0

TOTALNZ=6	2.0

Crop Group 9B – Cucurbit Vegetables – Squash Cucumbers

Chayote, fruit, Chinese waxgourd    	NB

NA

2.0

Cucumber, Balsam pear                        	NB	Field Trails

16 samples

16 detectable residues

MRID 45105301	6	3	NA	RDF# 21

Cucumber(100% CT)

TOTALZ=0

TOTALNZ=8	2.0

Pumpkin, Squash   	NB/PB	Field Trails

10 samples

10 detectable residues

MRID 45105301	100	100	NA	RDF# 22

Squash(100% CT)

TOTALZ=0

TOTALNZ=5	2.0

Crop Group O - Other

Banana, Plantain	NB/PB	Field Trails

30 samples

8 detectable residues

MRID 44828004	100	100	NA	RDF#1

Banana(100%CT)

Total Z=0

TotalNZ=30	0.1

Banana, Plantain,  dried	B	Field Trails

30 samples

8 detectable residues

MRID 44828004	100	100	3.9	Mean field trial (0.0107)	0.1

Water	NA	D351609	100	100	NA	0.017	0.011

1 Classification of blended (B), partially blended (PB), not blended
(NB).

2  A factor of 1.5X was applied to estimate residues convertible to
CGA-210007 for all commodities to account for all of the residues of
concern for dietary risk.  

III.	Water Data

Drinking water residues were incorporated directly into the acute and
chronic dietary analyses (“water, direct, all sources” and “water,
indirect, all sources”) and were provided by the Environmental Fate
and Effects Division (EFED) (D351609, R. Miller, 8-Aug-2008).  EFED
generated the surface water and ground water estimates using the   SEQ
CHAPTER \h \r 1 Pesticide Root Zone Model 3 (PRZM3; ver. 3.12.2;
2-May-2005)/Exposure Analysis Modeling System (EXAMS; ver. 2.98.04.06;
25-Apr-2005) and Screening Concentration in Ground Water (SCIGROW; Tier
1) models, respectively.  The residues of concern for drinking water
include acibenzolar-S-methyl and residues convertible to CGA-210007. 
EFED provided estimates for the proposed use of acibenzolar-S-methyl on
cucurbits because this use represents the highest use rate of the
proposed registered uses.  The SCI-GROW estimated ground water drinking
water concentrations for acibenzolar-S-methyl is not expected to exceed
4.08 x 10-5 µg/L and CGA 210007 is not expected to exceed 0.557 µg/L. 
Surface water EDWCs for acibenzolar-S-methyl, which were used in the
exposure assessment, are provided in Table 4.  

Acute (μg/L)	NonCancer Chronic (μg/L)	Cancer Chronic(μg/L)

Surface Water	Acibenzolar-S-Methyl1	0.74	0.10	0.05

Surface Water	CGA 2100072	14.21	9.48	5.47

1 Aerial application method

2 Degradation product formed after application 

CGA-210007 drinking water residues were included in the dietary exposure
assessment as acibenzolar-S-methyl equivalents.  CGA 210007 residues
were converted based on molecular weight as follows.    

Acute: 210 (acibenzolar-S-methyl MW) ÷ 180 (CGA 210007) x 14.21 (μg/L)
= 17 μg/L CGA 210007 

Chronic: 210 ÷ 180 x 9.48 (μg/L) = 11 μg/L CGA 210007 

IV.	DEEM-FCID™ Program and Consumption Information

Acibenzolar-S-Methyl acute and chronic dietary exposure assessments were
conducted using the Dietary Exposure Evaluation Model software with the
Food Commodity Intake Database (DEEM-FCID™, Version 2.03), which
incorporates consumption data from USDA’s Continuing Surveys of Food
Intakes by Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98
data are based on the reported consumption of more than 20,000
individuals over two non-consecutive survey days.  Foods “as
consumed” (e.g., apple pie) are linked to EPA-defined food commodities
(e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicly available recipe
translation files developed jointly by USDA/ARS and EPA.  For chronic
exposure assessment, consumption data are averaged for the entire U.S.
population and within population subgroups, but for acute exposure
assessment are retained as individual consumption events.  Based on
analysis of the 1994-96, 98 CSFII consumption data, which took into
account dietary patterns and survey respondents, HED concluded that it
is most appropriate to report risk for the following population
subgroups: the general U.S. population, all infants (<1 year old),
children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49,
females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form.  The resulting residue
consumption estimate for each food/food form is summed with the residue
consumption estimates for all other food/food forms on the commodity
residue list to arrive at the total average estimated exposure. 
Exposure is expressed in mg/kg body weight/day and as a percent of the
cPAD.  This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., those who reported eating
relevant commodities/food forms) and a per-capita (i.e., those who
reported eating the relevant commodities as well as those who did not)
basis.  In accordance with HED policy, per capita exposure and risk are
reported for all tiers of analysis.  However, for tiers 1 and 2,
significant differences in user vs. per capita exposure and risk are
identified and noted in the risk assessment.

V.	Toxicological Information

HED evaluated the toxicology data base for acibenzolar-S-methyl and
selected the following doses and endpoints for acute and chronic dietary
and drinking water risk assessments.  

Table 5. Summary of Toxicological Doses and Endpoints for
Acibenzolar-S-methyl  for Use in Dietary and Non-Occupational Human
Health Risk Assessments

Exposure/Scenario	Point of Departure	Uncertainty/FQPA Safety Factors
RfD, PAD, LOC for Risk Assessment	Study and Toxicological Effects

Acute Dietary (General Population)	An acute RfD for the general
population or any population subgroups was not selected  because no
effect attributable to a single (or few) day(s) oral exposure was
observed in animal studies.

Acute Dietary

(Females 13-49 years)	NOAEL = 8.2 mg/kg/day	UFA= 10x

UFH=10x

FQPA SF= 1x	Acute RfD = 0.082 mg/kg/day

aPAD = 0.082 mg/kg/day	Developmental Neurotoxicity Toxicity Study - Rat 

Developmental LOAEL = 82 mg/kg/day based on changes in brain
morphometrics in the cerebellum in offspring.  

Maternal LOAEL = was not observed NOAEL  = 4000 mg/kg/day HDT

Chronic Dietary 

(Females 13-49 years)	NOAEL = 8.2 mg/kg/day	UFA= 10x

UFH=10x

FQPA SF= 1x	Acute RfD = 0.082 mg/kg/day

aPAD = 0.082 mg/kg/day	Developmental Neurotoxicity Toxicity Study - Rat 

Developmental LOAEL = 82 mg/kg/day based on changes in brain
morphometrics in the cerebellum in offspring.  

Maternal LOAEL = was not observed 

NOAEL  = 4000 mg/kg/day HDT

Chronic Dietary 

(All Populations)	NOAEL = 25 mg/kg/day	UFA= 10x

UFH=10x

FQPA SF= 1x	Chronic RfD = 0.025

mg/kg/day

cPAD = 0.25 mg/kg/day	Chronic Toxicity - Dog; Co-critical;
Chronic/Cancer - Rat & Mouse, Reproduction Toxicity - Rat 

LOAEL = 25 mg/kg/day based on hemolytic anemia with compensatory
response.  

Cancer (all routes)	Not a Human Carcinogen

Point of Departure (POD) = A data point or an estimated point that is
derived from observed dose-response data and  used to mark the beginning
of extrapolation to determine risk associated with lower environmentally
relevant human exposures.  NOAEL = no observed adverse effect level.  

NOAEL = no observed adverse effect level.  

LOAEL = lowest observed adverse effect level.  

UF = uncertainty factor.  

UFA = extrapolation from animal to human (interspecies).  

UFH = potential variation in sensitivity among members of the human
population (intraspecies).  

FQPA SF = FQPA Safety Factor.  

PAD = population adjusted dose (a = acute, c = chronic).  

RfD = reference dose.  

VI.	Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned
when dietary risk exceeds 100% of the PAD.  The DEEM-FCID™ analyses
estimate the dietary exposure of the U.S. population and various
population subgroups.  The results reported in Tables 3 and 4 are for
the general U.S. Population, all infants (<1 year old), children 1-2,
children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49,
and adults 50+ years.

Results of Acute Dietary Exposure Analysis

The results of the acute dietary exposure analysis at the 99.9th
percentile of exposure are reported in Table 6.

Table 6:  Summary of Acute Dietary Exposure and Risk for
Acibenzolar-S-Methyl

Population Subgroup	aPAD (mg/kg/day)	Acute (99th Percentile)

Exposure (mg/kg/day)	%aPAD

Females 13-49 years old	0.082	0.0010	12

Results of Chronic Dietary Exposure Analysis

The results of the chronic dietary exposure analysis are reported in
Tables 7 and 8.  

Table 7:  Summary of Chronic Dietary Exposure and Risk for
Acibenzolar-S-Methyl 

Population Subgroup	aPAD (mg/kg/day)	Chronic

Exposure (mg/kg/day)	% cPAD

Females 13-49 years old	0.082	0.0038	5

Table 8:  Summary of Chronic Dietary Exposure and Risk for
Acibenzolar-S-Methyl

Population Subgroup	cPAD (mg/kg/day)	Chronic

Exposure (mg/kg/day)	% cPAD

General U.S. Population	0.25	0.0045	2

All Infants (< 1 year old)

0.0043	2

Children 1-2 years old

0.0093	4

Children 3-5 years old

0.0088	3.5

Children 6-12 years old

0.0059	2

Youth 13-19 years old

0.0043	2

Adults 20-49 years old

0.0038	1.5

Adults 50+ years old

0.0040	2

VI.	Characterization of Inputs/Outputs

The chronic dietary analysis is very conservative.  Tolerance level
residues used in the analysis are expected to exceed the residues
actually consumed.  In addition, the 100% crop treated estimate used for
all crops in the assessment will considerably overestimate the actual
percent  crop treated.  

The acute dietary analysis is refined.  The use of field trial data and
BEAD’s maximum

percent crop treated estimates in a probabilistic assessment provided
exposure estimates that are more likely to be representative of actual
exposures.  These estimates could be further refined, however by use of
percent crop treated estimates for the crops for which 100% crop treated
assumptions were made, use of monitoring data, market basket surveys,
washing factors, and cooking factors.  

VII.	Conclusions

A conservative chronic dietary exposure analysis was performed for the
general U.S. population and various population subgroups.  The risk
estimates for the general U.S. population and all population subgroups
are below HED’s level of concern.  The subgroup with the highest risk
estimate was females 13-49 with a cPAD of 5%.  The cPAD for the general
U.S. population was 2%.   A refined probabilistic acute dietary exposure
analysis was performed for the population subgroup Females 13-49.  The
resulting 99.9th percentile acute exposure estimate for females 13-49
years old is not of concern to HED (11% acute population adjustment dose
(aPAD)).   HED is confident that acute and chronic dietary exposures to
acibenzolar-S-methyl are not underestimated.

VIII.	List of Attachments

1.  Acute DEEM-FCID Residue Input File.

2.  Results of Acute DEEM-FCID Dietary Exposure Analysis.

3.  Chronic DEEM-FCID Residue Input File.

4.  Results of Chronic DEEM-FCID Dietary Exposure Analysis.

5.  Percent Crop Treated Estimates Provided by BEAD

6.  RDF Files Used in Acute Analysis

Attachment 1 Acute DEEM-FCID Residue Input File

Filename: F:\Acibenzolar\061402Acute1-21-09.R98  Chemical:
Acibenzolar-S-Methyl

RfD(Chronic): .082 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .082 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 01-21-2009/14:26:36/8          Program ver.
2.03

------------------------------------------------------------------------
--------

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1        Param #2  Param #3  Comment

  #   Code 

----- ---- ------------        --------  --------  -------

  1    6   Banana.rdf

  2    6   BellPep.rdf

  3    6   Broccoli.rdf

  4    6   Cabbage.rdf

  5    6   Celery.rdf

  6    6   LettuceH.rdf

  7    6   HotPep.rdf

  8    6   LettuceL.rdf

  9    6   Mustard.rdf

  10   6   Spinach.rdf

  11   6   Tomato.rdf

  12   6   BellPepOth.rdf

  13   6   BroccoliOth.rdf

  14   6   CabbageOth.rdf

  15   6   CeleryOth.rdf

  16   6   LettuceHRad.rdf

  17   6   HotPepOth.rdf

  18   6   SpinachOth.rdf

  19   6   TomatoOth.rdf

  20   6   Cantaloupe.rdf

  21   6   Cucumber.rdf

  22   6   Squash.rdf

  23   6   Onion.rdf

  EPA    Crop Commodity Name                    Def Res     Adj.Factors 
RDL  Comment

  Code    Grp                                    (ppm)       #1     #2  
Pntr

-------- ---- -------------------------------  ----------  ------ ------
---  -------

95000230 O    Banana                             0.100000   1.000  1.500
  1  Adjustment Factor 2

95000231 O    Banana-babyfood                    0.100000   1.000  1.500
     1.5X for Metabolites  

95000240 O    Banana, dried                      0.010700   3.900  1.500
     

95000241 O    Banana, dried-babyfood             0.010700   3.900  1.500
     

95002830 O    Plantain                           0.100000   1.000  1.500
  1  

95002840 O    Plantain, dried                    0.010700   3.900  1.500
     

86010000 O    Water, direct, all sources         0.017000   1.000  1.000
     

86020000 O    Water, indirect, all sources       0.017000   1.000  1.000
     

03002370 3    Onion, dry bulb                    0.070000   1.000  1.500
 23  

03002371 3    Onion, dry bulb-babyfood           0.070000   1.000  1.500
 23  

03002380 3    Onion, dry bulb, dried             0.029000   9.000  0.015
     

03002381 3    Onion, dry bulb, dried-babyfood    0.029000   9.000  0.015
     

03002390 3    Onion, green                       0.050000   1.000  1.500
     

03003380 3    Shallot                            0.050000   1.000  1.500
     

04010050 4A   Amaranth, leafy                    0.250000   1.000  1.500
 18  

04010180 4A   Arugula                            0.250000   1.000  1.500
 18  

04020760 4B   Cardoon                            0.250000   1.000  1.500
 15  

04020850 4B   Celery                             0.250000   1.000  1.500
  5  

04020851 4B   Celery-babyfood                    0.250000   1.000  1.500
  5  

04020860 4B   Celery, juice                      0.250000   1.000  1.500
  5  

04020870 4B   Celtuce                            0.250000   1.000  1.500
 15  

04011040 4A   Chrysanthemum, garland             0.250000   1.000  1.500
 18  

04011330 4A   Cress, garden                      0.250000   1.000  1.500
 18  

04011340 4A   Cress, upland                      0.250000   1.000  1.500
 18  

04011380 4A   Dandelion, leaves                  0.250000   1.000  1.500
 18  

04011500 4A   Endive                             0.250000   1.000  1.500
 18  

04021520 4B   Fennel, Florence                   0.250000   1.000  1.500
 15  

04012040 4A   Lettuce, head                      0.250000   1.000  1.500
  6  

04012050 4A   Lettuce, leaf                      0.250000   1.000  1.500
  8  

04012480 4A   Parsley, leaves                    0.250000   1.000  1.500
 18  

04013130 4A   Radicchio                          0.250000   1.000  1.500
 16  

04023220 4B   Rhubarb                            0.250000   1.000  1.500
 15  

04013550 4A   Spinach                            1.000000   1.000  1.500
 10  

04013551 4A   Spinach-babyfood                   1.000000   1.000  1.500
 10  

04023670 4B   Swiss chard                        0.250000   1.000  1.500
 15  

05010610 5A   Broccoli                           1.000000   1.000  1.500
  3  

05010611 5A   Broccoli-babyfood                  1.000000   1.000  1.500
  3  

05010620 5A   Broccoli, Chinese                  1.000000   1.000  1.500
 13  

05020630 5B   Broccoli raab                      1.000000   1.000  1.500
  9  

05010640 5A   Brussels sprouts                   1.000000   1.000  1.500
 14  

05010690 5A   Cabbage                            1.000000   1.000  1.500
  4  

05020700 5B   Cabbage, Chinese, bok choy         1.000000   1.000  1.500
  9  

05010710 5A   Cabbage, Chinese, napa             1.000000   1.000  1.500
 14  

05010720 5A   Cabbage, Chinese, mustard          1.000000   1.000  1.500
 13  

05010830 5A   Cauliflower                        1.000000   1.000  1.500
  3  

05021170 5B   Collards                           1.000000   1.000  1.500
  9  

05021940 5B   Kale                               1.000000   1.000  1.500
  9  

05011960 5A   Kohlrabi                           1.000000   1.000  1.500
 14  

05022290 5B   Mustard greens                     1.000000   1.000  1.500
  9  

05023180 5B   Rape greens                        1.000000   1.000  1.500
  9  

05023890 5B   Turnip, greens                     1.000000   1.000  1.500
  9  

08001480 8    Eggplant                           1.000000   1.000  1.500
 12  

08002340 8    Okra                               1.000000   1.000  1.500
 17  

08002700 8    Pepper, bell                       1.000000   1.000  1.500
  2  

08002701 8    Pepper, bell-babyfood              1.000000   1.000  1.500
  2  

08002710 8    Pepper, bell, dried                0.321000   1.000  0.015
     

08002711 8    Pepper, bell, dried-babyfood       0.321000   1.000  0.015
     

08002720 8    Pepper, nonbell                    1.000000   1.000  1.500
  7  

08002721 8    Pepper, nonbell-babyfood           1.000000   1.000  1.500
  7  

08002730 8    Pepper, nonbell, dried             0.321000   1.000  0.015
     

08003740 8    Tomatillo                          1.000000   1.000  1.500
 19  

08003750 8    Tomato                             1.000000   1.000  1.500
 11  

08003751 8    Tomato-babyfood                    1.000000   1.000  1.500
 11  

08003760 8    Tomato, paste                      0.164000   7.100  0.015
     

08003761 8    Tomato, paste-babyfood             0.164000   7.100  0.015
     

08003770 8    Tomato, puree                      0.164000   2.900  0.015
     

08003771 8    Tomato, puree-babyfood             0.164000   2.900  0.015
     

08003780 8    Tomato, dried                      0.164000  14.300  0.015
     

08003781 8    Tomato, dried-babyfood             0.164000  14.300  0.015
     

08003790 8    Tomato, juice                      1.000000   1.000  1.500
 11  

09020210 9B   Balsam pear                        1.000000   1.000  1.500
 21  

09010750 9A   Cantaloupe                         1.000000   1.000  1.500
 20  

09010800 9A   Casaba                             1.000000   1.000  1.500
 20  

09020880 9B   Chayote, fruit                     1.000000   1.000  1.500
 22  

09021020 9B   Chinese waxgourd                   1.000000   1.000  1.500
 21  

09021350 9B   Cucumber                           1.000000   1.000  1.500
 21  

09011870 9A   Honeydew melon                     1.000000   1.000  1.500
 20  

09023080 9B   Pumpkin                            1.000000   1.000  1.500
 22  

09023090 9B   Pumpkin, seed                      1.000000   1.000  1.500
 22  

09023560 9B   Squash, summer                     1.000000   1.000  1.500
 22  

09023561 9B   Squash, summer-babyfood            1.000000   1.000  1.500
 22  

09023570 9B   Squash, winter                     1.000000   1.000  1.500
 22  

09023571 9B   Squash, winter-babyfood            1.000000   1.000  1.500
 22  

09013990 9A   Watermelon                         1.000000   1.000  1.500
 20  

09014000 9A   Watermelon, juice                  1.000000   1.000  1.500
 20  

Attachment 2  Results of Acute DEEM-FCID Dietary Exposure Analysis

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for ACIBENZOLAR-S-METHYL               
(1994-98 data)

Residue file: 061402Acute2-3-09.R98                   Adjustment factor
#2 used.

Analysis Date: 03-03-2009/08:06:25    Residue file dated:
03-03-2009/07:52:46/8

Daily totals for food and foodform consumption used.

MC iterations = 5000      MC list in residue file     MC seed = 1128

Run Comment: ""

========================================================================
=======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
--------

Females 13-49 yrs:

                    0.001487     1.81    0.003473     4.24    0.009785  
 11.93 



Attachment 3  Chronic DEEM-FCID Residue Input File.

Filename: F:\Acibenzolar\061402Chron1-21-09.R98  Chemical:
Acibenzolar-S-Methyl

RfD(Chronic): .0367 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .0033 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 01-27-2009/09:03:15/8          Program ver.
2.03

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

95000230 O    Banana                             0.100000   1.000  1.500
 

95000231 O    Banana-babyfood                    0.100000   1.000  1.500
 

95000240 O    Banana, dried                      0.100000   3.900  1.500
 

95000241 O    Banana, dried-babyfood             0.100000   3.900  1.500
 

95002830 O    Plantain                           0.100000   1.000  1.500
 

95002840 O    Plantain, dried                    0.100000   3.900  1.500
 

86010000 O    Water, direct, all sources         0.017000   1.000  1.000
 

86020000 O    Water, indirect, all sources       0.017000   1.000  1.000
 

03002370 3    Onion, dry bulb                    0.100000   1.000  1.500
 

03002371 3    Onion, dry bulb-babyfood           0.100000   1.000  1.500
 

03002380 3    Onion, dry bulb, dried             0.100000   9.000  1.500
 

03002381 3    Onion, dry bulb, dried-babyfood    0.100000   9.000  1.500
 

03002390 3    Onion, green                       0.100000   1.000  1.500
 

03003380 3    Shallot                            0.100000   1.000  1.500
 

04010050 4A   Amaranth, leafy                    0.250000   1.000  1.500
 

04010180 4A   Arugula                            0.250000   1.000  1.500
 

04020760 4B   Cardoon                            0.250000   1.000  1.500
 

04020850 4B   Celery                             0.250000   1.000  1.500
 

04020851 4B   Celery-babyfood                    0.250000   1.000  1.500
 

04020860 4B   Celery, juice                      0.250000   1.000  1.500
 

04020870 4B   Celtuce                            0.250000   1.000  1.500
 

04011040 4A   Chrysanthemum, garland             0.250000   1.000  1.500
 

04011330 4A   Cress, garden                      0.250000   1.000  1.500
 

04011340 4A   Cress, upland                      0.250000   1.000  1.500
 

04011380 4A   Dandelion, leaves                  0.250000   1.000  1.500
 

04011500 4A   Endive                             0.250000   1.000  1.500
 

04021520 4B   Fennel, Florence                   0.250000   1.000  1.500
 

04012040 4A   Lettuce, head                      0.250000   1.000  1.500
 

04012050 4A   Lettuce, leaf                      0.250000   1.000  1.500
 

04012480 4A   Parsley, leaves                    0.250000   1.000  1.500
 

04013130 4A   Radicchio                          0.250000   1.000  1.500
 

04023220 4B   Rhubarb                            0.250000   1.000  1.500
 

04013550 4A   Spinach                            1.000000   1.000  1.500
 

04013551 4A   Spinach-babyfood                   1.000000   1.000  1.500
 

04023670 4B   Swiss chard                        0.250000   1.000  1.500
 

05010610 5A   Broccoli                           1.000000   1.000  1.500
 

05010611 5A   Broccoli-babyfood                  1.000000   1.000  1.500
 

05010620 5A   Broccoli, Chinese                  1.000000   1.000  1.500
 

05020630 5B   Broccoli raab                      1.000000   1.000  1.500
 

05010640 5A   Brussels sprouts                   1.000000   1.000  1.500
 

05010690 5A   Cabbage                            1.000000   1.000  1.500
 

05020700 5B   Cabbage, Chinese, bok choy         1.000000   1.000  1.500
 

05010710 5A   Cabbage, Chinese, napa             1.000000   1.000  1.500
 

05010720 5A   Cabbage, Chinese, mustard          1.000000   1.000  1.500
 

05010830 5A   Cauliflower                        1.000000   1.000  1.500
 

05021170 5B   Collards                           1.000000   1.000  1.500
 

05021940 5B   Kale                               1.000000   1.000  1.500
 

05011960 5A   Kohlrabi                           1.000000   1.000  1.500
 

05022290 5B   Mustard greens                     1.000000   1.000  1.500
 

05023180 5B   Rape greens                        1.000000   1.000  1.500
 

05023890 5B   Turnip, greens                     1.000000   1.000  1.500
 

08001480 8    Eggplant                           1.000000   1.000  1.500
 

08002340 8    Okra                               1.000000   1.000  1.500
 

08002700 8    Pepper, bell                       1.000000   1.000  1.500
 

08002701 8    Pepper, bell-babyfood              1.000000   1.000  1.500
 

08002710 8    Pepper, bell, dried                1.000000   1.000  1.500
 

08002711 8    Pepper, bell, dried-babyfood       1.000000   1.000  1.500
 

08002720 8    Pepper, nonbell                    1.000000   1.000  1.500
 

08002721 8    Pepper, nonbell-babyfood           1.000000   1.000  1.500
 

08002730 8    Pepper, nonbell, dried             1.000000   1.000  1.500
 

08003740 8    Tomatillo                          1.000000   1.000  1.500
 

08003750 8    Tomato                             1.000000   1.000  1.500
 

08003751 8    Tomato-babyfood                    1.000000   1.000  1.500
 

08003760 8    Tomato, paste                      3.000000   1.000  1.500
 

08003761 8    Tomato, paste-babyfood             3.000000   1.000  1.500
 

08003770 8    Tomato, puree                      1.000000   2.900  1.500
 

08003771 8    Tomato, puree-babyfood             1.000000   2.900  1.500
 

08003780 8    Tomato, dried                      1.000000  14.300  1.500
 

08003781 8    Tomato, dried-babyfood             1.000000  14.300  1.500
 

08003790 8    Tomato, juice                      1.000000   1.000  1.500
 

09020210 9B   Balsam pear                        2.000000   1.000  1.500
 

09010750 9A   Cantaloupe                         2.000000   1.000  1.500
 

09010800 9A   Casaba                             2.000000   1.000  1.500
 

09020880 9B   Chayote, fruit                     2.000000   1.000  1.500
 

09021020 9B   Chinese waxgourd                   2.000000   1.000  1.500
 

09021350 9B   Cucumber                           2.000000   1.000  1.500
 

09011870 9A   Honeydew melon                     2.000000   1.000  1.500
 

09023080 9B   Pumpkin                            2.000000   1.000  1.500
 

09023090 9B   Pumpkin, seed                      2.000000   1.000  1.500
 

09023560 9B   Squash, summer                     2.000000   1.000  1.500
 

09023561 9B   Squash, summer-babyfood            2.000000   1.000  1.500
 

09023570 9B   Squash, winter                     2.000000   1.000  1.500
 

09023571 9B   Squash, winter-babyfood            2.000000   1.000  1.500
 

09013990 9A   Watermelon                         2.000000   1.000  1.500
 

09014000 9A   Watermelon, juice                  2.000000   1.000  1.500
 

Attachment 4  Results of Chronic DEEM-FCID Dietary Exposure Analysis.

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for ACIBENZOLAR-S-METHYL             (1994-98
data)

Residue file name: C:\Documents and Settings\rdaiss\My
Documents\Acibenzolar\061402Chron1-15-09.R98                            
                        Adjustment factor #2 used.

Analysis Date 01-21-2009/14:35:21     Residue file dated:
01-15-2009/14:45:30/8

Reference dose (RfD, Chronic) = .082 mg/kg bw/day

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

Females 13-49 yrs                           0.003765                
4.6%

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for ACIBENZOLAR-S-METHYL             (1994-98
data)

Residue file name: C:\Documents and Settings\rdaiss\My
Documents\Acibenzolar\061402Chron1-21-09.R98                            
                         Adjustment factor #2 used.

Analysis Date 01-27-2009/09:04:26     Residue file dated:
01-27-2009/09:02:50/8

Reference dose (RfD, Chronic) = .25 mg/kg bw/day

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.004487                
1.8%

Northeast region                            0.004675                
1.9%

All infants (< 1 year)                      0.004307                
1.7%

Children 1-2 yrs                            0.009328                
3.7%

Children 3-5 yrs                            0.008826                
3.5%

Children 6-12 yrs                           0.005906                
2.4%

Youth 13-19 yrs                             0.003981                
1.6%

Adults 20-49 yrs                            0.003775                
1.5%

Adults 50+ yrs                              0.003977                
1.6%

Females 13-49 yrs                           0.003765                
1.5%

Attachment 5  Percent Crop Treated Estimates Provided by BEAD

6.  RDF Files Used in Acute Analysis

RDF #1

Banana		

%CT = 100

TOTALNZ = 30	

TOTALZ = 0	

0.01		

0.01		

0.01		

0.01		

0.01		

0.01		

0.01		

0.01		

0.01		

0.01		

0.01		

0.01		

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.02

0.04

0.03

0.04

0.07

0.02

0.04

0.05	RDF #2

Bell Pepper	

% CT=	5

TOTALNZ=9	

TOTALZ=171	

0.16		

0.28		

0.34		

0.40		

0.53		

0.29		

0.27		

0.30		

0.32	RDF #3

Broccoli		

% CT=	5	

TOTALNZ=11	

TOTALZ=209	

0.58		

0.28		

0.34		

0.42		

0.52		

0.17		

0.22		

0.32		

0.60		

0.60		

0.63	RDF #4

Cabbage		

% CT=	2.5

TOTALNZ=11

TOTALZ=429

0.57		

0.19		

0.22		

0.12		

0.14		

0.28		

0.36		

0.06		

0.09		

0.27		

0.35

	RDF #5

Celery

% CT=	1

TOTALNZ=9

TOTALZ=891

0.045

0.018	

0.016

0.050

0.043

0.058

0.042

0.077

0.063

RDF #6

Head Lettuce 

% CT=	12

TOTALNZ=12

TOTALZ=88	

0.081

0.075		

0.049

0.074

0.033		

0.041

0.044

0.039		

0.105

0.093		

0.043

0.055	RDF #7

Hot Pepper

% CT=	5

TOTALNZ=5

TOTALZ=95

0.50

0.41

0.35

0.21

0.32

	RDF #8

Leaf Lettuce

% CT=	12

TOTALNZ=11

TOTALZ=81

0.099

0.151

0.136

0.073

0.035

0.112

0.183

0.185

0.175

0.037

0.044	RDF #9

Mustard Greens

 % CT=	100

TOTALNZ=9

TOTALZ=0

0.74

0.53

0.64

0.71

0.80

0.26

0.32

0.14

0.18	RDF #10

Spinach	

% CT=	30

TOTALNZ=11

TOTALZ=26

0.273

0.326

0.247

0.418

0.538

0.110

0.138

0.232

0.262

0.230

0.190

RDF #11

Tomato

% CT=	5

TOTALNZ=23

TOTALZ=437

0.13

0.21

0.21

0.06

0.08

0.46

0.25

0.11

0.16

0.09

0.09

0.09

0.09

0.06

0.08

0.14

0.08

0.16

0.20

0.22

0.32

0.22

0.27

	RDF #12

BellPepperOth	

% CT=	100

TOTALNZ=9	

TOTALZ=0	

0.16		

0.28		

0.34		

0.40		

0.53		

0.29		

0.27		

0.30		

0.32	RDF #13

BroccoliOth	

% CT=	100	

TOTALNZ=11	

TOTALZ=0	

0.58		

0.28		

0.34		

0.42		

0.52		

0.17		

0.22		

0.32		

0.60		

0.60		

0.63	RDF #14

CabbageOth	

% CT=	100

TOTALNZ=11

TOTALZ=0

0.57		

0.19		

0.22		

0.12		

0.14		

0.28		

0.36		

0.06		

0.09		

0.27		

0.35

	RDF #15

CeleryOth

% CT=	100

TOTALNZ=9

TOTALZ=0

0.045

0.018	

0.016

0.050

0.043

0.058

0.042

0.077

0.063

RDF #16

LettuceHRad 

% CT=	100

TOTALNZ=12

TOTALZ=0	

0.081

0.075		

0.049

0.074

0.033		

0.041

0.044

0.039		

0.105

0.093		

0.043

0.055	RDF #17

HotPepperOth

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100

TOTALNZ=5

TOTALZ=0

0.50

0.41

0.35

0.21

0.32	RDF #18

SpinachOth	

% CT=	100

TOTALNZ=11

TOTALZ=0

0.273

0.326

0.247

0.418

0.538

0.110

0.138

0.232

0.262

0.230

0.190	RDF #19

TomatoOth

% CT=	100

TOTALNZ=23

TOTALZ=0

0.13

0.21

0.21

0.06

0.08

0.46

0.25

0.11

0.16

0.09

0.09

0.09

0.09

0.06

0.08

0.14

0.08

0.16

0.20

0.22

0.32

0.22

0.27	RDF #20

Cantaloupe

 % CT=	100

TOTALNZ=6	

TOTALZ=0

0.235

0.759

0.240

0.279

0.278

0.134

RDF #21

Cucumber

 % CT=	100

TOTALNZ=8

TOTALZ=0

0.166

0.508

0.183

0.210

0.218

0.215

0.155

0.132	RDF #22

Squash		

% CT=	100

TOTALNZ=5

TOTALZ=0

0.152

0.418

0.151

0.187

0.172

	RDF #23

Onion 

 % CT=	100

TOTALNZ=7

TOTALZ=0

0.025

0.025

0.025

0.056

0.025

0.025

0.025

Acibenzolar-S-Methyl (PC Code 061402)	Dietary Exposure and Risk
Assessment                    DP #:  362208

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