Document ID: EPA-HQ-OPP-2004-0411-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2004-12-21T05:00Z

Ametryn
Dietary
Exposure
Assessment
DP
Barcode:
D307103
PC
Code:
080801
Page:
1
of
13
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
MEMORANDUM
DATE:
06­
OCT­
2004
SUBJECT:
Ametryn.
Chronic
and
Cancer
Dietary
Exposure
Assessments
for
the
Reregistration
Eligibility
Decision
PC
Code:
080801
DP
Barcode:
D307103
REVIEWER:
William
H.
Donovan,
Ph.
D.,
Chemist
Reregistration
Branch
3
Health
Effects
Division
(
7509C)

THROUGH:
David
Soderberg,
Chemist
Susan
Stanton,
Environmental
Scientist
Dietary
Exposure
Science
Advisory
Council
(
DESAC)
Health
Effects
Division
(
7509C)

and
Danette
Drew,
Branch
Senior
Scientist
Reregistration
Branch
3
Branch/
Health
Effects
Division
(
7509C)

TO:
John
Doherty,
Toxicologist
Reregistration
Branch
3
Health
Effects
Division
(
7509C)

Executive
Summary
Chronic
and
cancer
dietary
risk
assessments
were
conducted
using
Lifeline
 
(
ver.
2.0)
and
the
Dietary
Exposure
Evaluation
Model
­
Food
Consumption
Intake
Database
(
DEEM­
FCID
 
,
Version
2.0)
models.
Both
of
these
models
use
food
consumption
data
from
the
USDA's
Ametryn
Dietary
Exposure
Assessment
DP
Barcode:
D307103
PC
Code:
080801
Page:
2
of
13
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII)
from
1994­
1996
and
1998.
The
analyses
were
performed
to
support
the
reregistration
eligibility
decision
for
ametryn.

The
chronic
and
cancer
analyses
were
conducted
using
average
residue
levels
from
applicable
field
trials,
percent
crop
treated
information
and
DEEM
(
ver.
7.76)
default
processing
factors.
The
Lifeline
 
chronic
exposure
estimates
were
<
0.1%
cPAD
for
all
population
subgroups
and
are
therefore
less
than
HED's
level
of
concern.
The
lifetime
cancer
risk
calculated
in
Lifeline
 
for
the
US
population
is
2.7
x
10­
8
and
is
therefore
less
than
HED's
level
of
concern
(
HED
performs
cancer
assessments
for
only
the
general
US
population).
DEEM­
FCID
 
resulted
in
chronic
and
cancer
exposure
estimates
nearly
identical
to
those
from
Lifeline
 
.
The
present
assessment
is
refined
as
it
makes
use
of
average
residue
levels
from
field
trial
results,
default
processing
factors,
and
percent
crop
treated
information.

I.
Introduction
Dietary
risk
assessment
incorporates
both
exposure
and
toxicity
of
a
given
pesticide.
For
chronic
assessments,
the
risk
is
expressed
as
a
percentage
of
a
maximum
acceptable
dose
(
i.
e.,
the
dose
which
HED
has
concluded
will
result
in
no
unreasonable
adverse
health
effects).
This
dose
is
referred
to
as
the
population
adjusted
dose
(
PAD).
The
PAD
is
equivalent
to
the
Reference
Dose
(
RfD)
divided
by
the
special
FQPA
Safety
Factor.

For
non­
cancer
chronic
exposures,
HED
is
concerned
when
estimated
dietary
risk
exceeds
100%
of
the
PAD.
For
cancer
exposures,
HED
is
generally
concerned
when
estimated
cancer
risks
exceed
one
in
one
million
(
i.
e.,
the
risk
exceeds
1
x
10­
6).
References
which
discuss
the
acute
and
chronic
risk
assessments
in
more
detail
are
available
on
the
EPA/
pesticides
web
site:
"
Available
Information
on
Assessing
Exposure
from
Pesticides,
A
User's
Guide,"
6/
21/
2000,
web
link:
http://
www.
epa.
gov/
fedrgstr/
EPA­
PEST/
2000/
July/
Day­
12/
6061.
pdf
;
or
see
SOP
99.6
(
8/
20/
99).

This
memo
documents
the
first
HED
dietary
risk
assessment
for
ametryn.

II.
Residue
Information
Tolerances
for
residues
of
ametryn
in/
on
a
variety
of
crops
are
listed
under
40
CFR
§
180.258.
However,
because
the
registrant
is
only
supporting
ametryn
uses
on
corn,
sugarcane,
and
pineapple,
these
are
the
only
crops
that
were
included
in
the
present
dietary
analysis.
Anticipated
residue
values
were
used
for
this
dietary
exposure
analysis,
based
on
average
crop
field
trial
data.
Residue
data
for
pineapple
was
taken
from
MRID
419095­
02,
"
Ametryn
 
Pineapple
Residue
Summary".
This
study
reports
the
results
of
8
pineapple
field
trials
conducted
in
Hawaii.
As
residue
levels
from
two
pineapple
fruit
samples
were
reported
for
each
trial,
an
average
of
the
16
residue
levels
was
computed
for
use
as
an
anticipated
residue
level
for
the
chronic
dietary
analysis.
The
data
collection
method
LOQ
was
0.02
ppm.
Thus,
residue
levels
reported
as
<
LOQ
were
taken
to
be
½
LOQ
or
0.01
ppm.
Table
1
lists
the
pineapple
results
used
to
determine
the
anticipated
residue
level
for
ametryn
residues
in
pineapple.
Ametryn
Dietary
Exposure
Assessment
DP
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Table
1.
Ametryn
Residue
Levels
in
Hawaiian
Pineapple
Field
Trialsa.

Island
Fruit
variety
Trial
ID
DALAb
Ametryn
(
ppm)

Oahu:
Wahiawa
Dole
Wahiawa
96­
20­
26
161
<
0.02
Oahu:
Wahiawa
Dole
Wahiawa
96­
20­
26
161
<
0.02
Oahu:
Kunia
Del
Monte
W135W1
160
<
0.02
Oahu:
Kunia
Del
Monte
W135W1
160
<
0.02
Oahu:
Kunia
Del
Monte
W135W2
160
<
0.02
Oahu:
Kunia
Del
Monte
W135W2
160
<
0.02
Oahu:
Kunia
Del
Monte
W135W3
160
<
0.02
Oahu:
Kunia
Del
Monte
W135W3
160
<
0.02
Maui
Maui
Pineapple
89­
3.1
161
<
0.02
Maui
Maui
Pineapple
89­
3.1
161
<
0.02
Maui
Maui
Pineapple
89­
3.2
151
<
0.02
Maui
Maui
Pineapple
89­
3.2
151
<
0.02
Lanai
Dole
Lanai
96­
20­
27
142
0.027
Lanai
Dole
Lanai
96­
20­
27
142
0.033
Lanai
Dole
Lanai
96­
20­
28
142
0.034
Lanai
Dole
Lanai
96­
20­
28
142
0.050
Average
Residue
0.017
a
All
trials
involved
one
treatment
with
Evik
 
80W
at
a
rate
of
7.2
lb
ai/
A.
b
Days
after
last
application.

All
corn
grain
and
sugarcane
samples
treated
at
a
1x
rate
had
ametryn
residue
levels
reported
as
<
0.02
ppm
(
LOQ).
Thus,
the
anticipated
residue
levels
used
for
the
chronic
analysis
of
ametryn
are
as
follows:
corn,
0.01
ppm;
sugarcane,
0.01
ppm;
and
pineapple,
0.017
ppm.

Percent
crop
treated
information
as
provided
by
BEAD
was
as
follows:
corn,
3%;
sugarcane,
30
%;
and
pineapple,
100
%
(
Ametryn
Use
Closure
Memo,
M.
Howard,
27­
FEB­
2004).
The
following
default
processing
factors
from
DEEM
(
Ver
7.76)
were
used:
corn,
syrup
1.5;
pineapple,
juice
1.7;
and
pineapple,
dried
5.0.

III
Program
and
Consumption
Information
Ametryn
Dietary
Exposure
Assessment
DP
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D307103
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Several
reasonable
peer­
reviewed
software
programs
have
recently
been
emerging
for
modeling
dietary
exposure
to
pesticides.
For
a
variety
of
technical,
historical,
and
availability
reasons,
DEEMTM
was
the
program
generally
used
by
EPA's
Office
of
Pesticide
Programs
for
conducting
its
dietary
risk
assessments.
With
the
advent
and
current
availability
of
a
number
of
other
exposure
software
programs,
OPP,
registrants,
and
other
interested
parties
have
available
to
them
the
option
of
selecting
other
peer­
reviewed
exposure
software
in
conducting
risk
assessments
for
pesticides.
LifelineTM
is
one
such
model
and
is
the
software
being
used
in
this
review,
in
addition
to
DEEM­
FCID
 
.
Dietary
Exposure
assessments
may
also
be
performed
with
other,
similar
programs,
and
if
submitted,
such
results
will
be
reviewed
by
EPA
for
acceptability
and
comparability
to
existing
peer­
reviewed
software
being
used
by
OPP.

IIIa.
DEEM­
FCID
 
Program
and
Consumption
Information
Ametryn
chronic
dietary
exposure
assessments
were
conducted
using
the
Dietary
Exposure
Evaluation
Model
software
with
the
Food
Commodity
Intake
Database
(
DEEM­
FCID
 
,
Version
2.0),
which
incorporates
consumption
data
from
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII),
1994­
1996
and
1998.
The
1994­
1996,
1998
data
are
based
on
the
reported
consumption
of
more
than
20,000
individuals
over
two
non­
consecutive
survey
days.
Foods
"
as
consumed"
(
e.
g.,
apple
pie)
are
linked
to
EPA­
defined
food
commodities
(
e.
g.
apples,
peeled
fruit
­
cooked;
fresh
or
N/
S;
baked;
or
wheat
flour
­
cooked;
fresh
or
N/
S,
baked)
using
publicly
available
recipe
translation
files
developed
jointly
by
USDA/
ARS
and
EPA.
For
chronic
exposure
assessment,
consumption
data
are
averaged
for
the
entire
U.
S.
population
and
within
population
subgroups,
but
for
acute
exposure
assessment
are
retained
as
individual
consumption
events.
Based
on
analysis
of
the
1994­
1996,
1998
CSFII
consumption
data,
which
took
into
account
dietary
patterns
and
survey
respondents,
HED
concluded
that
it
is
most
appropriate
to
report
risk
for
the
following
population
subgroups:
the
general
U.
S.
population,
all
infants
(<
1
year
old),
children
1­
2
years
old,
children
3­
5
years
old,
children
6­
12
years
old,
youth
13­
19
years
old,
adults
20­
49
years
old,
females
13­
49
years
old,
and
adults
50+
years
old.

For
chronic
dietary
exposure
assessment,
an
estimate
of
the
residue
level
in
each
food
or
foodform
(
e.
g.,
orange
or
orange
juice)
on
the
food
commodity
residue
list
is
multiplied
by
the
average
daily
consumption
estimate
for
that
food/
food
form
to
produce
a
residue
intake
estimate.
The
resulting
residue
intake
estimate
for
each
food/
food
form
is
summed
with
the
residue
intake
estimates
for
all
other
food/
food
forms
on
the
commodity
residue
list
to
arrive
at
the
total
average
estimated
exposure.
Exposure
is
expressed
in
mg/
kg
body
weight/
day
and
as
a
percent
of
the
cPAD.
This
procedure
is
performed
for
each
population
subgroup.
Ametryn
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Exposure
Assessment
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III
b.
Lifeline
 
Program
and
Consumption
Information
Chronic
dietary
exposure
estimates
were
also
conducted
using
the
Lifeline
 
model
(
Version
2.0).
These
Lifeline
 
assessments
were
also
conducted
using
the
same
consumption
data
as
the
DEEM­
FCID
 
(
CSFII,
1994­
1996
and
1998
consumption
data
with
FCID).
Lifeline
 
uses
the
recipe
file
to
relate
RACs
to
foods
"
as­
eaten."
Lifeline
 
converts
the
RAC
residues
into
food
residues
by
randomly
selecting
a
RAC
residue
value
from
the
"
user
defined"
residue
distribution
(
created
from
the
residue,
percent
crop
treated,
and
processing
factors
data),
and
calculating
a
net
residue
for
that
food
based
on
the
ingredients'
mass
contribution
to
that
food
item.
For
example,
`
apple
pie'
will
have
a
residue
distribution
based
on
the
residues
provided
for
apples
(
adjusted
by
the
appropriate
processing
factors
and
percent
crop
treated),
as
well
as
the
residues
for
each
of
the
other
ingredients
in
the
apple
pie
recipe
for
which
there
may
be
tolerances.
Lifeline
 
calculates
dietary
exposure
from
`
apple
pie'
based
on
the
amount
eaten,
and
the
residue
drawn
from
the
`
apple
pie'
residue
distribution
for
that
eating
occasion.

Lifeline
 
models
the
individual's
dietary
exposures
over
a
season
by
selecting
a
new
CSFII
diary
each
day
from
a
set
of
similar
individuals
based
on
age
and
season
attributes.
Lifeline
 
groups
CSFII
diaries
based
on
the
respondents'
age
and
the
season
during
which
the
food
diary
was
recorded.
Further
information
regarding
the
Lifeline
 
model
can
be
found
at
the
following
web
site:
www.
theLifeline
 
group.
org.

IV.
Toxicological
Information
The
doses
and
endpoints
for
use
in
the
dietary
assessments
were
selected
by
the
ametryn
risk
assessment
team.
The
database
is
substantially
complete
and
no
concerns
were
identified
that
would
necessitate
a
hazard­
based
special
FQPA
safety
factor.
The
relevant
doses
and
endpoints
for
dietary
exposure
assessment
are
presented
in
Table
2.
Although
the
CARC
made
no
classification
of
ametryn
with
regards
to
carcinogenic
potential
due
to
inadequate
data
and
requested
that
the
registrant
conduct
a
new
cancer
study,
a
Q
1*
estimate
of
0.0066
(
mg/
kg/
day)­
1
based
on
the
most
sensitive
tumor
was
derived
from
the
available
database
(
personal
communication,
Ray
Kent,
14­
SEP­
2004).
The
ametryn
risk
assessment
team,
in
consultation
with
the
HED
Hazard
Assessment
Science
Policy
Council
(
HASPC),
decided
to
conduct
the
preliminary
cancer
risk
assessment
reported
in
this
document
using
the
estimated
Q
1*
value
for
ametryn.
The
ametryn
team
believes
that
using
the
Q
1*
based
on
existing
data
will
reasonably
approximate
cancer
risk
to
humans
and
considers
it
unlikely
that
the
requested
new
cancer
study
will
result
in
a
higher
risk
for
ametryn.
Support
for
this
conclusion
comes
from
the
observation
that
there
were
no
tumors
in
the
rat
study
at
500
ppm,
a
dose
resulting
in
minimal
body
weight
decrease
and
the
fact
that
there
were
no
compound
related
tumors
in
the
mouse
study
at
dose
levels
up
to
and
including
2000
ppm.
Ametryn
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Exposure
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Table
2.
Summary
of
Toxicological
Doses
and
Endpoints
for
Ametryn
for
Use
in
Dietary
Exposure
Assessment
Exposure
Scenario
Dose
Used
in
Risk
Assessment,
UF
Hazard
and
Exposure
Based
Special
FQPA
Safety
Factor
Study
and
Toxicological
Effects
Acute
Dietary
(
General
population
including
infants
and
children)
No
toxicological
effect
attributable
to
a
single
dose
identified.
This
risk
assessment
is
not
required.

Acute
Dietary
(
Females
13­
50
years
of
age)
No
toxicological
effect
attributable
to
a
single
dose
identified.
This
risk
assessment
is
not
required.

Chronic
Dietary
(
All
populations)
NOAEL=
7.2
mg/
kg/
day
UF
=
100
Chronic
RfD
=
0.072
mg/
kg/
day
FQPA
SF
=
1X
cPAD
=
chronic
RfD
FQPA
SF
=
0.072
mg/
kg/
day
Dog
chronic
feeding
study
with
indications
of
degenerative
and
inflammatory
liver
effects
at
70
mg/
kg/
day.

Cancer
The
Cancer
Assessment
Review
Committee
(
CARC)
met
to
evaluate
the
carcinogenic
potential
of
ametryn
on
21­
JUL­
2004
and
concluded
that
the
"
data
are
inadequate
for
an
assessment
of
human
carcinogenic
potential".
The
carcinogenicity
study
in
rats
is
unacceptable
because
the
high
dose
was
considered
to
be
excessive.
The
CARC
requested
that
the
carcinogenicity
study
in
rats
be
repeated
at
a
dose
that
is
adequate
to
assess
carcinogenicity.
However,
the
available
data
allow
for
a
determination
of
a
Q1*
value
of
0.0066
(
mg/
kg/
day)­
1,
based
on
observations
of
combined
mammary
tumors
in
female
rats.
The
ametryn
risk
assessment
team
believes
that
using
the
estimated
Q1*
based
on
existing
data
will
reasonably
approximate
cancer
risk
to
humans
and
considers
it
unlikely
that
the
requested
new
cancer
study
will
result
in
a
higher
risk
for
ametryn.
Support
for
this
conclusion
comes
from
the
observation
that
there
were
no
tumors
in
the
rat
study
at
500
ppm,
a
dose
resulting
in
minimal
body
weight
decrease
and
the
fact
that
there
were
no
compound
related
tumors
in
the
mouse
study
at
dose
levels
up
to
and
including
2000
ppm.

V.
Results/
Discussion
As
stated
above,
for
chronic
assessments,
HED
is
concerned
when
dietary
risk
exceeds
100%
of
the
PAD
and
for
cancer
assessments
HED
is
concerned
when
the
lifetime
risk
for
the
general
US
population
exceeds
1
x
10­
6.
The
following
paragraphs
are
summaries
of
the
DEEM­
FCID
 
(
version
2.0)
and
Lifeline
 
(
version
2.0)
chronic
and
cancer
exposure
analyses.
Tables
3
and
4
summarize
the
results
from
these
analyses.
Note
that
the
results
from
both
models
are
in
close
accord
with
one
another.

Lifeline
 
:
Chronic
and
cancer
dietary
exposure
analyses
were
performed
using
Lifeline
 
(
ver
2.0).
The
chronic
dietary
exposure
estimates
were
<
0.1%
cPAD
for
all
population
subgroups
and
are
therefore
less
than
HED's
level
of
concern.
The
lifetime
cancer
risk
for
the
US
Ametryn
Dietary
Exposure
Assessment
DP
Barcode:
D307103
PC
Code:
080801
Page:
7
of
13
population
is
2.7
x
10­
8
and
is
therefore
less
than
HED's
level
of
concern
(
HED
performs
cancer
assessments
for
the
general
US
population
only).

DEEM
 
­
FCID
 
:
Chronic
and
cancer
dietary
exposure
analyses
were
performed
using
DEEMFCID
 
(
ver.
2.0).
The
chronic
dietary
exposure
estimates
were
<
0.1%
cPAD
for
all
population
subgroups
and
are
therefore
less
than
HED's
level
of
concern.
The
lifetime
cancer
risk
for
the
US
population
is
2.7
x
10­
8
and
is
therefore
less
than
HED's
level
of
concern
(
HED
performs
cancer
assessments
for
the
general
US
population
only).

Table
3.
Summary
of
Dietary
Exposure
and
Risk
for
Ametryn
Population
Subgroup
Dietary
Exposure
(
mg/
kg/
day)
%
cPAD
1
DEEM­
FCID
 
Lifeline
 
DEEM­
FCID
 
Lifeline
 
Chronic
Assessment
General
U.
S.
Population
0.000004
0.000004
<
0.1
<
0.1
All
Infants
(<
1
year
old)
0.000008
0.000008
<
0.1
<
0.1
Children
1­
2
years
old
0.000018
0.000018
<
0.1
<
0.1
Children
3­
5
years
old
0.000013
0.000014
<
0.1
<
0.1
Children
6­
12
years
old
0.000008
0.000008
<
0.1
<
0.1
Youth
13­
19
years
old
0.000003
0.000004
<
0.1
<
0.1
Adults
20­
49
years
old
0.000003
0.000003
<
0.1
<
0.1
Adults
50+
years
old
0.000002
0.000003
<
0.1
<
0.1
Females
13­
49
years
old
0.000003
0.000003
<
0.1
<
0.1
1
HED
is
generally
not
concerned
if
the
%
PAD
is
less
than
100%.

Table
4.
Summary
of
Cancer
Dietary
Exposure
and
Risk
for
Ametryn
Population
Subgroup
Q1*
cPAD
(
mg/
kg/
day)­
1
Exposure
(
mg/
kg/
day)
Lifetime
risk
Lifeline
 
DEEMFCID
 
Lifeline
 
DEEM­
FCID
 
General
US
Population
0.0066
0.000004
0.000004
2.72
x
10­
8
2.74
x
10­
8
Ametryn
Dietary
Exposure
Assessment
DP
Barcode:
D307103
PC
Code:
080801
Page:
8
of
13
VI.
Characterization
of
Inputs/
Outputs
The
dietary
exposures
estimated
in
this
analysis
are
likely
higher
than
actual
exposures
to
ametryn.
Average
field
trial
residue
levels
were
used
for
the
chronic
analysis,
together
with
percent
crop
treated
information
and
default
processing
factors;
thus,
the
present
assessment
may
be
considered
to
be
refined.

VII.
Conclusions
Chronic
and
cancer
dietary
risk
assessments
were
conducted
for
ametryn
(
acute
analysis
not
applicable).
The
Lifeline
 
and
DEEM­
FCID
 
chronic
exposure
estimates
were
<
0.1%
cPAD
for
all
population
subgroups,
and
therefore
less
than
HED's
level
of
concern.
The
Lifeline
 
and
DEEM­
FCID
 
lifetime
cancer
risk
for
the
US
Population
was
2.7
x
10­
8
and
therefore
also
less
than
HED's
level
of
concern.
The
present
assessment
is
refined
as
it
makes
use
of
average
residue
levels
from
field
trial
results,
default
processing
factors,
and
percent
crop
treated
information.

VIII.
List
of
Attachments
Attachment
1:
Lifeline
 
chronic/
cancer
residue
file
Attachment
2:
Lifeline
 
chronic
exposure
estimates
Attachment
3:
DEEM­
FCID
 
chronic/
cancer
residue
file
Attachment
4:
DEEM­
FCID
 
chronic
exposure
estimates
Attachment
5:
DEEM­
FCID
 
cancer
exposure
estimates
cc
with
all
attachments:
W.
Donovan
(
RRB3)
W.
Donovan:
821G:
CM#
2:(
703)
305­
7330:
7590C
Ametryn
Dietary
Exposure
Assessment
DP
Barcode:
D307103
PC
Code:
080801
Page:
9
of
13
Attachment
1:
Lifeline
 
chronic/
cancer
residue
file
Crop
Group
Commodity
FoodForm
Residue
Dehydration
Use
Factor
CEREAL
GRAINS
Corn,
field,
flour
All
.01
CEREAL
GRAINS
Corn,
field,
flour­
babyfood
All
.01
CEREAL
GRAINS
Corn,
field,
meal
All
.01
CEREAL
GRAINS
Corn,
field,
meal­
babyfood
All
.01
CEREAL
GRAINS
Corn,
field,
bran
All
.01
CEREAL
GRAINS
Corn,
field,
starch
All
.01
CEREAL
GRAINS
Corn,
field,
starch­
babyfood
All
.01
CEREAL
GRAINS
Corn,
field,
syrup
All
.01
CEREAL
GRAINS
Corn,
field,
syrup­
babyfood
All
.01
CEREAL
GRAINS
Corn,
field,
oil
All
.01
CEREAL
GRAINS
Corn,
field,
oil­
babyfood
All
.01
CEREAL
GRAINS
Corn,
pop
All
.01
CEREAL
GRAINS
Corn,
sweet
All
.01
CEREAL
GRAINS
Corn,
sweet­
babyfood
All
.01
MISC.
Pineapple
All
.017
MISC.
Pineapple­
babyfood
All
.017
MISC.
Pineapple,
dried
All
.017
MISC.
Pineapple,
juice
All
.017
MISC.
Pineapple,
juice­
babyfood
All
.017
MISC.
Sugarcane,
sugar
All
.01
MISC.
Sugarcane,
sugar­
babyfood
All
.01
MISC.
Sugarcane,
molasses
All
.01
MISC.
Sugarcane,
molasses
­
babyfood
All
.01
CEREAL
GRAINS
Corn,
field,
syrup
All
1.5
CEREAL
GRAINS
Corn,
field,
syrup­
babyfood
All
1.5
MISC.
Pineapple,
dried
All
5
MISC.
Pineapple,
juice
All
1.7
MISC.
Pineapple,
juice­
babyfood
All
1.7
CEREAL
GRAINS
Corn,
field,
flour
All
.03
CEREAL
GRAINS
Corn,
field,
flour­
babyfood
All
.03
CEREAL
GRAINS
Corn,
field,
meal
All
.03
CEREAL
GRAINS
Corn,
field,
meal­
babyfood
All
.03
CEREAL
GRAINS
Corn,
field,
bran
All
.03
CEREAL
GRAINS
Corn,
field,
starch
All
.03
CEREAL
GRAINS
Corn,
field,
starch­
babyfood
All
.03
CEREAL
GRAINS
Corn,
field,
syrup
All
.03
CEREAL
GRAINS
Corn,
field,
syrup­
babyfood
All
.03
CEREAL
GRAINS
Corn,
field,
oil
All
.03
CEREAL
GRAINS
Corn,
field,
oil­
babyfood
All
.03
CEREAL
GRAINS
Corn,
pop
All
.03
CEREAL
GRAINS
Corn,
sweet
All
.03
CEREAL
GRAINS
Corn,
sweet­
babyfood
All
.03
MISC.
Sugarcane,
sugar
All
.3
MISC.
Sugarcane,
sugar­
babyfood
All
.3
MISC.
Sugarcane,
molasses
All
.3
MISC.
Sugarcane,
molasses
­
babyfood
All
.3
Ametryn
Dietary
Exposure
Assessment
DP
Barcode:
D307103
PC
Code:
080801
Page:
10
of
13
Attachment
2:
Lifeline
 
chronic
exposure
estimates
age_
group
mean
cPAD_
mean
NOAEL
UFFQPA
cPAD
RNOAEL
RUFFQPA
RcPAD
General
U.
S.
Population
4.11531E­
06
0.005715706
7.2
100
0.072
All
Infants
(<
1
year
old)
8.48067E­
06
0.011778705
7.2
100
0.072
Children
1­
2
years
old
1.82924E­
05
0.025406094
7.2
100
0.072
Children
3­
5
years
old
1.42957E­
05
0.019855171
7.2
100
0.072
Children
6­
12
years
old
7.75716E­
06
0.010773832
7.2
100
0.072
Youth
13­
19
years
old
4.00734E­
06
0.005565753
7.2
100
0.072
Adults
20­
49
years
old
2.89953E­
06
0.004027122
7.2
100
0.072
Adults
50+
years
old
2.68407E­
06
0.003727876
7.2
100
0.072
Females
13­
49
years
old
3.47185E­
06
0.004822021
7.2
100
0.072
Ametryn
Dietary
Exposure
Assessment
DP
Barcode:
D307103
PC
Code:
080801
Page:
11
of
13
Attachment
3:
DEEM­
FCID
 
chronic/
cancer
residue
file
Filename:
C:\
BackupFiles\
Ametryn\
080801c.
R98
Chemical:
Ametryn
RfD(
Chronic):
.072
mg/
kg
bw/
day
NOEL(
Chronic):
7.2
mg/
kg
bw/
day
RfD(
Acute):
0
mg/
kg
bw/
day
NOEL(
Acute):
0
mg/
kg
bw/
day
Q*=
.0066
Date
created/
last
modified:
09­
27­
2004/
13:
36:
44/
8
Program
ver.
2.03
Comment:
avg
residue
levels
&
%
CT
corrections
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
EPA
Crop
Def
Res
Adj.
Factors
Comment
Code
Grp
Commodity
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
15001200
15
Corn,
field,
flour
0.010000
1.000
0.030
15001201
15
Corn,
field,
flour­
babyfood
0.010000
1.000
0.030
15001210
15
Corn,
field,
meal
0.010000
1.000
0.030
15001211
15
Corn,
field,
meal­
babyfood
0.010000
1.000
0.030
15001220
15
Corn,
field,
bran
0.010000
1.000
0.030
15001230
15
Corn,
field,
starch
0.010000
1.000
0.030
15001231
15
Corn,
field,
starch­
babyfood
0.010000
1.000
0.030
15001240
15
Corn,
field,
syrup
0.010000
1.500
0.030
15001241
15
Corn,
field,
syrup­
babyfood
0.010000
1.500
0.030
15001250
15
Corn,
field,
oil
0.010000
1.000
0.030
15001251
15
Corn,
field,
oil­
babyfood
0.010000
1.000
0.030
15001260
15
Corn,
pop
0.010000
1.000
0.030
15001270
15
Corn,
sweet
0.010000
1.000
0.030
15001271
15
Corn,
sweet­
babyfood
0.010000
1.000
0.030
95002790
O
Pineapple
0.017000
1.000
1.000
95002791
O
Pineapple­
babyfood
0.017000
1.000
1.000
95002800
O
Pineapple,
dried
0.017000
5.000
1.000
95002810
O
Pineapple,
juice
0.017000
1.700
1.000
95002811
O
Pineapple,
juice­
babyfood
0.017000
1.700
1.000
95003620
O
Sugarcane,
sugar
0.010000
1.000
0.300
95003621
O
Sugarcane,
sugar­
babyfood
0.010000
1.000
0.300
95003630
O
Sugarcane,
molasses
0.010000
1.000
0.300
95003631
O
Sugarcane,
molasses­
babyfood
0.010000
1.000
0.300
Ametryn
Dietary
Exposure
Assessment
DP
Barcode:
D307103
PC
Code:
080801
Page:
12
of
13
Attachment
4:
DEEM­
FCID
 
chronic
exposure
estimates
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
AMETRYN
(
1994­
98
data)
Residue
file
name:
C:\
BackupFiles\
Ametryn\
080801c.
R98
Adjustment
factor
#
2
used.
Analysis
Date
09­
27­
2004/
13:
37:
16
Residue
file
dated:
09­
27­
2004/
13:
36:
44/
8
Reference
dose
(
RfD,
Chronic)
=
.072
mg/
kg
bw/
day
COMMENT
1:
avg
residue
levels
&
%
CT
corrections
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.000004
0.0%

U.
S.
Population
(
spring
season)
0.000004
0.0%
U.
S.
Population
(
summer
season)
0.000004
0.0%
U.
S.
Population
(
autumn
season)
0.000004
0.0%
U.
S.
Population
(
winter
season)
0.000004
0.0%

Northeast
region
0.000004
0.0%
Midwest
region
0.000004
0.0%
Southern
region
0.000004
0.0%
Western
region
0.000005
0.0%

Hispanics
0.000005
0.0%
Non­
hispanic
whites
0.000004
0.0%
Non­
hispanic
blacks
0.000005
0.0%
Non­
hisp/
non­
white/
non­
black
0.000004
0.0%

All
infants
(<
1
year)
0.000008
0.0%
Nursing
infants
0.000004
0.0%
Non­
nursing
infants
0.000010
0.0%
Children
1­
6
yrs
0.000014
0.0%
Children
7­
12
yrs
0.000007
0.0%

Females
13­
19
(
not
preg
or
nursing)
0.000003
0.0%
Females
20+
(
not
preg
or
nursing)
0.000003
0.0%
Females
13­
50
yrs
0.000004
0.0%
Females
13+
(
preg/
not
nursing)
0.000005
0.0%
Females
13+
(
nursing)
0.000008
0.0%

Males
13­
19
yrs
0.000003
0.0%
Males
20+
yrs
0.000002
0.0%
Seniors
55+
0.000002
0.0%

Children
1­
2
yrs
0.000018
0.0%
Children
3­
5
yrs
0.000013
0.0%
Children
6­
12
yrs
0.000008
0.0%
Youth
13­
19
yrs
0.000003
0.0%
Adults
20­
49
yrs
0.000003
0.0%
Adults
50+
yrs
0.000002
0.0%
Females
13­
49
yrs
0.000003
0.0%

­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Ametryn
Dietary
Exposure
Assessment
DP
Barcode:
D307103
PC
Code:
080801
Page:
13
of
13
Attachment
5:
DEEM­
FCID
 
cancer
exposure
estimates
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
AMETRYN
(
1994­
98
data)
Residue
file
name:
C:\
BackupFiles\
Ametryn\
080801c.
R98
Adjustment
factor
#
2
used.
Analysis
Date
09­
27­
2004/
13:
38:
17
Residue
file
dated:
09­
27­
2004/
13:
36:
44/
8
Q*
=
0.0066
COMMENT
1:
avg
residue
levels
&
%
CT
corrections
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Lifetime
risk
Subgroup
body
wt/
day
(
Q*=
.0066)
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.000004
2.74E­
08