Document ID: EPA-HQ-OPP-2006-0523-0007
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2007-06-22T04:00Z

SEQ CHAPTER \h \r 1 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF              

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES 

MEMORANDUM

DATE:  	6 March 2007

SUBJECT:	Thiamethoxam Acute and Chronic Aggregate Dietary and Drinking
Water Exposure and Risk Assessments for FIFRA Section 3 Registration

PC Code:	060109			Decision Number:  366608

DP Number:	335846

REVIEWER:	Michael Doherty, Ph.D., Chemist

Registration Action Branch II

Health Effects Division (7509P)

THROUGH:	Sheila Piper, Chemist

Amelia Acierto, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P)

and

Richard A. Loranger, Ph.D., Branch Senior Scientist

Registration Action Branch II

Health Effects Division (7509P)

TO:		Michael Doherty, Ph.D., Chemist

		Registration Action Branch II

		Health Effects Division (7509P)

and

Dani Daniel/Venus Eagle, Product Manager

Insecticide/Rodenticide Branch

Registration Division (7505P)

Executive Summary

Acute and chronic dietary risk assessments were conducted using the
Dietary Exposure Evaluation Model (DEEM-FCID™, Version 2.03) which use
food consumption data from the U.S. Department of Agriculture’s
Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996
and 1998.  The analyses were performed to evaluate Section 3 requests
for new uses or revised uses of thiamethoxam on artichoke, barley,
brassica vegetables, bushberry, caneberry, cotton, cranberry, cucurbit
vegetables, fruiting vegetables, hops, juneberry, leafy vegetables,
legume vegetables, lingonberry, mint, oilseed crops, pecan, pome fruit,
potato seed pieces, root vegetables (except sugarbeet), salal, stone
fruit, strawberry, tobacco, and tuberous and corm vegetables.

Thiamethoxam’s major metabolite is CGA-322704, which is also the
registered active ingredient clothianidin.  Clothianidin has a complete
toxicological database and appears to have effects in mammals that are
different from those of thiamethoxam.  Nevertheless, in conducting these
assessments, residues of clothianidin coming from thiamethoxam were
added to residues of thiamethoxam per se.  The total residue was then
used to estimate dietary exposure and risk.  Both the acute and chronic
assessments assumed that 100% of crops with registered or requested uses
of thiamethoxam were treated.  This assumption is highly conservative
with respect to thiamethoxam use and removes the need to include
residues of clothianidin coming from clothianidin uses.  The last risk
assessment for clothianidin (M. Doherty, 9/13/06, D326758) included
residues of clothianidin coming from these uses of thiamethoxam.

   

Both the acute and chronic dietary assessments are based on maximum
residues of thiamethoxam and clothianidin observed in the thiamethoxam
field trials.  As noted above, these assessments assume that 100% of
crops with registered or requested uses of thiamethoxam are treated. In
addition, both the acute and chronic assessments assume the maximum
modeled concentration of thiamethoxam in drinking water (12.26 µg/L). 
These assumptions result in conservative, health-protective estimates of
exposure.  Risk estimates for acute dietary exposure for all assessed
population subgroups are less than 4% of the acute population-adjusted
dose (aPAD).  These estimates are well below HED’s level of concern
(generally 100% of the aPAD).  Similarly, risk estimates for the chronic
dietary exposure analysis are below HED’s level of concern, with the
maximum estimate being 42% of the chronic population-adjusted dose
(cPAD).

These analyses indicate that there are no dietary exposure
considerations that would preclude registration of thiamethoxam for the
requested uses.

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to the reference dose (RfD) divided by the
special Food Quality Protection Act (FQPA) Safety Factor.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  References which
discuss the acute and chronic risk assessments in more detail are
available on the EPA/pesticides web site:  “Available Information on
Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web
link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see
SOP 99.6 (8/20/99).

The most recent dietary risk assessment for thiamethoxam was conducted
by W. Cutchin (D278328, 12/16/2003).

II.	Residue Information

Thiamethoxam is registered for a number of commodities, with tolerances
ranging from 0.02 to 1.5 ppm [40 CFR 180.565].  The major metabolite of
thiamethoxam (CGA-322704) is identical to the registered active
ingredient clothianidin.  These two compounds make up the residues of
concern for risk assessments for thiamethoxam.

Both the acute and chronic dietary analyses are based on the maximum
residues of thiamethoxam and clothianidin that were observed in the
thiamethoxam field trials.  Although there is available information
indicating that thiamethoxam and clothianidin have different
toxicological effects in mammals and should be assessed separately, the
residues of each have been combined in these assessments to ensure that
the estimated exposures do not underestimate actual potential exposures.
 In calculating the total residue (thiamethoxam + clothianidin),
clothianidin residues were converted to thiamethoxam equivalents by
multiplying by the molecular weight ratio (1.15) of these two compounds
(Table 1).  Maximum values, rather than tolerance values, were used in
the assessments in order to keep the same level of acute refinement as
was used recently for clothianidin.  Empirical processing factors were
used when available.  For food forms without empirical processing
factors, DEEM 7.78 default values were used.  An assumption of 100% crop
treated was made for all foods evaluated in the assessments.  Label
instructions for these ingredients regarding best management practices
prohibit application of another Group 4A (neonicotinoid) insecticide
during the growing season.  Therefore, the assumption of 100% crop
treated in these assessments removes the need to quantitatively consider
the impact of clothianidin uses on exposure and risk estimates
associated with thiamethoxam.  A complete listing of the inputs used in
the assessments can be found in Attachment 1.  The estimates of residues
in livestock commodities are unaltered from those used in the previous
assessment and are not shown in Table 1.  

 Table 1.  Summary of Thiamethoxam and Clothianidin (from Thiamethoxam
Application) Residues Used in the Acute and Chronic Dietary Assessments
for Thiamethoxam.

Group	Crop	Maximum Residue, ppm

Thiamethoxam	Clothianidin	Combined 1

Bushberry	Blueberry	0.110	0.050	0.168

Caneberry	Raspberry/Blackberry	0.200	0.040	0.246

Cereal Grain	All, except barley	0.005	0.005	0.011

Cereal Grain	Barley	0.210	0.020	0.233

Cucurbit Veg	Canteloupe	0.140	0.005	0.146

Cucurbit Veg	Cucumber	0.100	0.005	0.106

Cucurbit Veg	Summer Squash	0.130	0.005	0.136

Fruiting Veg.	Bell and non-bell peppers	0.220	0.020	0.243

Fruiting Veg.	Tomato	0.140	0.040	0.186

Fruiting Veg.	Tomato, paste	0.608	0.152	0.783

Head/Stem Brassica	Head/Stem Brassica	0.160	0.040	0.206

Leafy Brassica	Cabbage	0.120	0.020	0.143

Leafy Brassica	Mustard Green	1.600	0.360	2.014

Leafy Veg.	Celery	0.400	0.020	0.423

Leafy Veg.	Head Lettuce	0.060	0.005	0.066

Leafy Veg.	Leaf Lettuce	1.900	0.040	1.946

Leafy Veg.	Spinach	0.660	0.800	1.580

Legume Veg.	Vegetable, legume, Group 6	0.005	0.005	0.011

Oilseed	Borage, seed	0.005	0.005	0.011

Oilseed	Canola, seed	0.005	0.005	0.011

Oilseed	Crambe, seed	0.005	0.005	0.011

Oilseed	Flax, seed	0.005	0.005	0.011

Oilseed	Mustard, seed	0.005	0.005	0.011

Oilseed	Rapeseed, seed	0.005	0.005	0.011

Oilseed	Safflower, seed	0.005	0.005	0.011

Oilseed	Sunflower	0.005	0.005	0.011

Other	Artichoke, globe	0.244	0.029	0.278

Other	Coffee	0.010	0.010	0.022

Other	Cotton, undelinted seed	0.030	0.005	0.036

Other	Cranberry	0.005	0.005	0.011

Other	Grape	0.260	0.020	0.283

Other	Grape - Juice	0.231	0.020	0.254

Other	Grape - Raisins	1.222	0.020	1.245

Other	Hop	0.055	0.028	0.087

Other	Peppermint/Spearmint	0.894	0.128	1.041

Other	Strawberry	0.260	0.005	0.266

Pome Fruit	Apple	0.110	0.005	0.116

Pome Fruit	Pear	0.060	0.005	0.066

Root Veg.	Carrot	0.040	0.005	0.046

Root Veg.	Radish	0.080	0.005	0.086

Stone Fruit	Cherry	0.280	0.030	0.315

Stone Fruit	Peach	0.190	0.120	0.328

Stone Fruit	Plum	0.020	0.020	0.043

Tree Nut	Pecans	0.005	0.005	0.011

Tuber	Tuberous and Corm (inc. tol.)	0.240	0.060	0.309

Tuber	Vegetable, tuberous and corm, except potato, Subgroup 1D	0.005
0.005	0.011

1 The combined residues are expressed as thiamethoxam equivalents (i.e.,
thiamethoxam residue + 1.15×clothianidin residue).

 Drinking Water Data

The Estimated Drinking Water Concentrations (EDWCs) used in the dietary
risk assessment were provided by the Environmental Fate and Effects
Division (EFED; A. Al-Mudallal, D329467, 10 Jan. 07).  The EDWCs were
incorporated directly into this dietary assessment in the food
categories “water, direct, all sources” and “water, indirect, all
sources.”

Estimated drinking water concentrations for surface water are Tier II
PRZM/EXAM results based on the index reservoir scenarios and percent
crop area factors.  Uses on apples, barley, cabbage, carrots, cucumbers,
grapes, lettuce, peppers, strawberries, tomatoes, and turf were modeled.
 The greatest residues in surface water are predicted to result from use
of thiamethoxam on peppers in Florida (acute, 12.26 µg/L) and lettuce
in California (chronic, 1.29 µg/L).

For groundwater, EFED used the SCI-GROW model based on the highest
proposed annual use rate (grapes).  The SCI-GROW model estimated
residues of thiamethoxam in shallow groundwater to be 7.94 µg/L.

These models and their descriptions can be found at the EPA internet
site (  HYPERLINK "http://www.epa.gov/oppefed1/models/water/" 
http://www.epa.gov/oppefed1/models/water/ ).

Both the acute and chronic assessment used the acute EDWC of 12.26 µg/L
(0.0123 ppm) as a worst-case estimate of exposure via drinking water.

IV.	DEEM-FCID™ Program and Consumption Information

Thiamethoxam acute and chronic dietary exposure assessments were
conducted using the Dietary Exposure Evaluation Model software with the
Food Commodity Intake Database (DEEM-FCID™, Version 2.03), which
incorporates consumption data from USDA’s Continuing Surveys of Food
Intakes by Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98
data are based on the reported consumption of more than 20,000
individuals over two non-consecutive survey days.  Foods “as
consumed” (e.g., apple pie) are linked to EPA-defined food commodities
(e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicly available recipe
translation files developed jointly by USDA/ARS and EPA.  For chronic
exposure assessment, consumption data are averaged for the entire U.S.
population and within population subgroups, but for acute exposure
assessment are retained as individual consumption events.  Based on
analysis of the 1994-96, 98 CSFII consumption data, which took into
account dietary patterns and survey respondents, HED concluded that it
is most appropriate to report risk for the following population
subgroups: the general U.S. population, all infants (<1 year old),
children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49,
females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., only those who reported
eating relevant commodities/food forms) and a per-capita (i.e., those
who reported eating the relevant commodities as well as those who did
not) basis.  In accordance with HED policy, per capita exposure and risk
are reported for all tiers of analysis.  However, for tiers 1 and 2, any
significant differences in user vs. per capita exposure and risk are
specifically identified and noted in the risk assessment.

V.	Toxicological Information

The toxicology database for thiamethoxam is complete.  The scientific
quality is relatively high and the toxicity profile of thiamethoxam can
be characterized for most effects, including potential carcinogenic,
mutagenic, developmental, and neurotoxic effects.  Newly submitted data
has resulted in revisions to the acute and chronic points of departure
and doses for risk assessment (see Table 2).

It is recommended that the 10X FQPA safety factor for the protection of
infants and children be reduced to 1X.  There is no quantitative or
qualitative evidence of increased susceptibility of rat or rabbit
fetuses to in utero exposure to thiamethoxam in the developmental
toxicity studies.  The developmental NOAELs are either higher than or
equal to the maternal NOAELs.  The Developmental Neurotoxity (DNT)
workgroup concluded there was no evidence of increased  quantitative
susceptibility in the DNT study in rats, based on evaluation of
additional brain morphometric data for the low- and mid-dose pups
(January 17, 2007 meeting).  

 

Although there is evidence of increased quantitative susceptibility for
male pups of both two generation reproductive studies, NOAELs and LOAELs
were established in these studies, and the Agency selected the NOAEL for
testicular effects in F1 pups as the basis for risk assessment.  The
Agency has confidence that the NOAEL selected for risk assessment is
protective of the most sensitive effect (testicular effects) for the
most sensitive subgroup (pups) observed in the toxicological database.  
 

 

In addition, the NOAELs selected for risk assessment are protective of
all toxicological effects observed in the database including
treatment-related changes in the adrenal gland, thyroid, testes and
ovaries.  Thus, the Agency believes the FQPA safety factor can be
reduced to 1X.

Table 2.  Toxicological Doses and Endpoints for Thiomethoxam for Use in
Human Health Risk Assessments

Exposure/

Scenario	Point of Departure	Uncertainty/FQPA Safety Factors	Level of
Concern for Risk Assessment	Study and Toxicological Effects

Acute Dietary

All populations including infants and children 	NOAEL =  34.5 mg/kg/day

	UFA= 10x

UFH= 10x

SFFQPA=1

 	aRfD=0.35 mg/kg/day

aPAD=0.35 mg/kg/day	Rat Developmental Neurotoxicity study 

LOAEL = 298.7 mg/kg/day based on delayed sexual maturation in male pups,
and reduced brain morphometric measurements.

Chronic Dietary

All populations including infants and children	NOAEL= 1.2 mg/kg/day
(46402904) 

	UFA= 10x

UFH= 10x

SFFQPA=1

	cRfD=0.012 mg/kg/day

cPAD=0.012 mg/kg/day	2-Generation reproduction study (MRID 44718707)

LOAEL = 1.8 mg/kg/day based on increased incidence and severity of
tubular atrophy in testes of F1 generation males.

2-Generation reproduction study (46402904) 

LOAEL = 3 (males), not determined (females) mg/kg/day based on sperm
abnormalities in F1 males.

Cancer (oral, dermal, inhalation)	“Not Likely to be Carcinogenic to
Humans” based on convincing evidence that a non-genotoxic mode of
action for liver tumors was established in the mouse and that the
carcinogenic effects are a result of a mode of action dependent on
sufficient amounts of a hepatotoxic metabolite produced persistently. 
Quantification of cancer risk is not required.   

VI.	Results/Discussion

Table 3.  Summary of Estimated Dietary (Food + Water) Exposures and Risk
for Thiamethoxam.

Population Subgroup	aPAD, mg/kg	Acute Estimates	cPAD, mg/kg/day	Chronic
Estimates

Exposure, mg/kg	Risk, % aPAD

Exposure, mg/kg/day	Risk, % cPAD

U.S. Population	0.35	0.004698	1	0.012	0.001630	14

All infants	0.35	0.009228	3	0.012	0.003298	28

Children 1-2 yrs	0.35	0.011707	3	0.012	0.005005	42

Children 3-5 yrs	0.35	0.008783	3	0.012	0.003718	31

Children 6-12 yrs	0.35	0.005098	1	0.012	0.002092	17

Youth 13-19 yrs	0.35	0.003206	1	0.012	0.001285	11

Adults 20-49 yrs	0.35	0.003069	1	0.012	0.001245	10

Adults 50+ yrs	0.35	0.003403	1	0.012	0.001361	11

Females 13-49 yrs	0.35	0.003151	1	0.012	0.001248	10

The population subgroup with the highest estimated exposure/risk is
bolded.

As stated above, for acute and chronic assessments, HED is concerned
when dietary risk exceeds 100% of the PAD.  The DEEM-FCID™ analyses
estimate the dietary exposure of the U.S. population and various
population subgroups.  The results reported in Table 3 are for the
general U.S. Population, all infants (<1 year old), children 1-2,
children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49,
and adults 50+ years.  The acute results summarized in Table 2 are for
the 95th percentile of exposure.  A complete listing of acute and
chronic exposure and risk estimates can be found in Attachments 2 and 3,
respectively.

The analyses indicate that the requested uses of thiamethoxam, coupled
with currently registered uses, will result in acute and chronic dietary
(food + water) exposures that are below HED’s level of concern for all
population subgroups, including those of infants and children.

VII.	Characterization of Inputs/Outputs

Assumptions regarding estimates of residue levels and the extent to
which crops are treated with thiamethoxam are highly conservative and
protective of human health; especially in the case of the chronic
assessment.  Actual dietary exposures to thiamethoxam and clothianidin
are likely to be significantly less than the estimates provided by the
DEEM-FCID simulations.

VIII.	Conclusions

Based on highly conservative assumptions, there are no dietary (food +
water) exposure considerations that would preclude registration of
thiamethoxam on the requested food/feed crops or establishment of
tolerances at HED’s recommended levels (see CHEM REFERENCE)

IX.		List of Attachments

Attachment 1.  Input file for the acute and chronic dietary exposure
analyses of thiamethoxam.

Attachment 2.  Summary of the acute dietary exposure analysis for
thiamethoxam.

Attachment 3.  Summary of the chronic dietary exposure analysis for
thiamethoxam.

Attachment 1.  Input file for the acute and chronic dietary exposure
analyses of thiamethoxam.

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for THIAMETHOXAM                      
1994-98 data

Residue file: C:\Documents and Settings\mdoherty\My Documents\Chemistry
Reviews\DEEM Runs\Clothianidin and Thiamethoxam\Thiamethoxam\060109 2006
Acute T + C from T + Water no CT.R98

                                                           Adjust. #2
NOT used

Analysis Date 01-23-2007             Residue file dated:
01-23-2007/13:48:49/8

Reference dose (RfD) = 0.012 mg/kg bw/day

Comment:Acute and Chronic RfDs = aPAD and cPAD

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

04010050 4A   Amaranth, leafy                    1.580000   1.000     
1.000   

11000070 11   Apple, fruit with peel             0.116000   1.000     
1.000   

11000080 11   Apple, peeled fruit                0.116000   1.000     
1.000   

11000081 11   Apple, peeled fruit-babyfood       0.116000   1.000     
1.000   

11000090 11   Apple, dried                       0.116000   1.000     
1.000   

11000091 11   Apple, dried-babyfood              0.116000   1.000     
1.000   

11000100 11   Apple, juice                       0.116000   1.000     
1.000   

11000101 11   Apple, juice-babyfood              0.116000   1.000     
1.000   

11000110 11   Apple, sauce                       0.116000   1.000     
1.000   

11000111 11   Apple, sauce-babyfood              0.116000   1.000     
1.000   

12000120 12   Apricot                            0.328000   1.000     
1.000   

12000121 12   Apricot-babyfood                   0.328000   1.000     
1.000   

12000130 12   Apricot, dried                     0.328000   6.000     
1.000   

12000140 12   Apricot, juice                     0.328000   1.000     
1.000   

12000141 12   Apricot, juice-babyfood            0.328000   1.000     
1.000   

01030150 1CD  Arrowroot, flour                   0.011000   1.000     
1.000   

01030151 1CD  Arrowroot, flour-babyfood          0.011000   1.000     
1.000   

95000160 O    Artichoke, globe                   0.278000   1.000     
1.000   

01030170 1CD  Artichoke, Jerusalem               0.011000   1.000     
1.000   

04010180 4A   Arugula                            1.580000   1.000     
1.000   

09020210 9B   Balsam pear                        0.106000   1.000     
1.000   

15000250 15   Barley, pearled barley             0.233000   0.300     
1.000   

15000251 15   Barley, pearled barley-babyfood    0.233000   0.300     
1.000   

15000260 15   Barley, flour                      0.233000   0.100     
1.000   

15000261 15   Barley, flour-babyfood             0.233000   0.100     
1.000   

15000270 15   Barley, bran                       0.233000   1.000     
1.000   

06030300 6C   Bean, black, seed                  0.010000   1.000     
1.000   

06020310 6B   Bean, broad, succulent             0.010000   1.000     
1.000   

06030320 6C   Bean, broad, seed                  0.010000   1.000     
1.000   

06020330 6B   Bean, cowpea, succulent            0.010000   1.000     
1.000   

06030340 6C   Bean, cowpea, seed                 0.010000   1.000     
1.000   

06030350 6C   Bean,  great northern, seed        0.010000   1.000     
1.000   

06030360 6C   Bean, kidney, seed                 0.010000   1.000     
1.000   

06020370 6B   Bean, lima, succulent              0.010000   1.000     
1.000   

06030380 6C   Bean, lima, seed                   0.010000   1.000     
1.000   

06030390 6C   Bean, mung, seed                   0.010000   1.000     
1.000   

06030400 6C   Bean, navy, seed                   0.010000   1.000     
1.000   

06030410 6C   Bean, pink, seed                   0.010000   1.000     
1.000   

06030420 6C   Bean, pinto, seed                  0.010000   1.000     
1.000   

06010430 6A   Bean, snap, succulent              0.010000   1.000     
1.000   

06010431 6A   Bean, snap, succulent-babyfood     0.010000   1.000     
1.000   

21000440 M    Beef, meat                         0.020000   1.000     
1.000   

21000441 M    Beef, meat-babyfood                0.020000   1.000     
1.000   

21000450 M    Beef, meat, dried                  0.020000   1.920     
1.000   

21000460 M    Beef, meat byproducts              0.020000   1.000     
1.000   

21000461 M    Beef, meat byproducts-babyfood     0.020000   1.000     
1.000   

21000480 M    Beef, kidney                       0.020000   1.000     
1.000   

21000490 M    Beef, liver                        0.020000   1.000     
1.000   

21000491 M    Beef, liver-babyfood               0.020000   1.000     
1.000   

01010500 1AB  Beet, garden, roots                0.086000   1.000     
1.000   

01010501 1AB  Beet, garden, roots-babyfood       0.086000   1.000     
1.000   

13010550 13A  Blackberry                         0.246000   1.000     
1.000   

13010560 13A  Blackberry, juice                  0.246000   1.000     
1.000   

13010561 13A  Blackberry, juice-babyfood         0.246000   1.000     
1.000   

13020570 13B  Blueberry                          0.168000   1.000     
1.000   

13020571 13B  Blueberry-babyfood                 0.168000   1.000     
1.000   

13010580 13A  Boysenberry                        0.246000   1.000     
1.000   

05010610 5A   Broccoli                           0.206000   1.000     
1.000   

05010611 5A   Broccoli-babyfood                  0.206000   1.000     
1.000   

05010620 5A   Broccoli, Chinese                  0.206000   1.000     
1.000   

05020630 5B   Broccoli raab                      2.014000   1.000     
1.000   

05010640 5A   Brussels sprouts                   0.143000   1.000     
1.000   

15000650 15   Buckwheat                          0.011000   1.000     
1.000   

15000660 15   Buckwheat, flour                   0.011000   1.000     
1.000   

01010670 1AB  Burdock                            0.086000   1.000     
1.000   

05010690 5A   Cabbage                            0.143000   1.000     
1.000   

05020700 5B   Cabbage, Chinese, bok choy         2.014000   1.000     
1.000   

05010710 5A   Cabbage, Chinese, napa             0.143000   1.000     
1.000   

05010720 5A   Cabbage, Chinese, mustard          0.206000   1.000     
1.000   

09010750 9A   Cantaloupe                         0.146000   1.000     
1.000   

04020760 4B   Cardoon                            0.423000   1.000     
1.000   

01010780 1AB  Carrot                             0.046000   1.000     
1.000   

01010781 1AB  Carrot-babyfood                    0.046000   1.000     
1.000   

01010790 1AB  Carrot, juice                      0.046000   1.000     
1.000   

09010800 9A   Casaba                             0.146000   1.000     
1.000   

01030820 1CD  Cassava                            0.011000   1.000     
1.000   

01030821 1CD  Cassava-babyfood                   0.011000   1.000     
1.000   

05010830 5A   Cauliflower                        0.206000   1.000     
1.000   

01010840 1AB  Celeriac                           0.085000   1.000     
1.000   

04020850 4B   Celery                             0.423000   1.000     
1.000   

04020851 4B   Celery-babyfood                    0.423000   1.000     
1.000   

04020860 4B   Celery, juice                      0.423000   1.000     
1.000   

04020870 4B   Celtuce                            0.423000   1.000     
1.000   

09020880 9B   Chayote, fruit                     0.136000   1.000     
1.000   

12000900 12   Cherry                             0.315000   1.000     
1.000   

12000901 12   Cherry-babyfood                    0.315000   1.000     
1.000   

12000910 12   Cherry, juice                      0.315000   1.000     
1.000   

12000911 12   Cherry, juice-babyfood             0.315000   1.000     
1.000   

06030980 6C   Chickpea, seed                     0.010000   1.000     
1.000   

06030981 6C   Chickpea, seed-babyfood            0.010000   1.000     
1.000   

06030990 6C   Chickpea, flour                    0.010000   1.000     
1.000   

01011000 1AB  Chicory, roots                     0.046000   1.000     
1.000   

09021020 9B   Chinese waxgourd                   0.106000   1.000     
1.000   

04011040 4A   Chrysanthemum, garland             1.580000   1.000     
1.000   

95001150 O    Coffee, roasted bean               0.022000   1.000     
1.000   

95001160 O    Coffee, instant                    0.022000   1.000     
1.000   

05021170 5B   Collards                           2.014000   1.000     
1.000   

15001200 15   Corn, field, flour                 0.011000   1.000     
1.000   

15001201 15   Corn, field, flour-babyfood        0.011000   1.000     
1.000   

15001210 15   Corn, field, meal                  0.011000   1.000     
1.000   

15001211 15   Corn, field, meal-babyfood         0.011000   1.000     
1.000   

15001220 15   Corn, field, bran                  0.011000   1.000     
1.000   

15001230 15   Corn, field, starch                0.011000   1.000     
1.000   

15001231 15   Corn, field, starch-babyfood       0.011000   1.000     
1.000   

15001240 15   Corn, field, syrup                 0.011000   1.000     
1.000   

15001241 15   Corn, field, syrup-babyfood        0.011000   1.000     
1.000   

15001250 15   Corn, field, oil                   0.011000   1.000     
1.000   

15001251 15   Corn, field, oil-babyfood          0.011000   1.000     
1.000   

15001260 15   Corn, pop                          0.011000   1.000     
1.000   

15001270 15   Corn, sweet                        0.011000   1.000     
1.000   

15001271 15   Corn, sweet-babyfood               0.011000   1.000     
1.000   

95001280 O    Cottonseed, oil                    0.036000   1.000     
1.000   

95001281 O    Cottonseed, oil-babyfood           0.036000   1.000     
1.000   

11001290 11   Crabapple                          0.116000   1.000     
1.000   

95001300 O    Cranberry                          0.011000   1.000     
1.000   

95001301 O    Cranberry-babyfood                 0.011000   1.000     
1.000   

95001310 O    Cranberry, dried                   0.011000   1.000     
1.000   

95001320 O    Cranberry, juice                   0.011000   1.000     
1.000   

95001321 O    Cranberry, juice-babyfood          0.011000   1.000     
1.000   

04011330 4A   Cress, garden                      1.580000   1.000     
1.000   

04011340 4A   Cress, upland                      1.580000   1.000     
1.000   

09021350 9B   Cucumber                           0.106000   1.000     
1.000   

13021360 13B  Currant                            0.168000   1.000     
1.000   

13021370 13B  Currant, dried                     0.168000   1.000     
1.000   

04011380 4A   Dandelion, leaves                  1.580000   1.000     
1.000   

01031390 1CD  Dasheen, corm                      0.011000   1.000     
1.000   

13011420 13A  Dewberry                           0.246000   1.000     
1.000   

08001480 8    Eggplant                           0.240000   1.000     
1.000   

13021490 13B  Elderberry                         0.168000   1.000     
1.000   

04011500 4A   Endive                             1.580000   1.000     
1.000   

04021520 4B   Fennel, Florence                   0.423000   1.000     
1.000   

20001630 20   Flaxseed, oil                      0.011000   1.000     
1.000   

01031660 1CD  Ginger                             0.011000   1.000     
1.000   

01031661 1CD  Ginger-babyfood                    0.011000   1.000     
1.000   

01031670 1CD  Ginger, dried                      0.011000   1.000     
1.000   

01011680 1AB  Ginseng, dried                     0.046000   1.000     
1.000   

23001690 M    Goat, meat                         0.020000   1.000     
1.000   

23001700 M    Goat, meat byproducts              0.020000   1.000     
1.000   

23001720 M    Goat, kidney                       0.020000   1.000     
1.000   

23001730 M    Goat, liver                        0.020000   1.000     
1.000   

13021740 13B  Gooseberry                         0.168000   1.000     
1.000   

95001750 O    Grape                              0.283000   1.000     
1.000   

95001760 O    Grape, juice                       0.283000   0.890     
1.000   

95001761 O    Grape, juice-babyfood              0.283000   0.890     
1.000   

95001770 O    Grape, leaves                      0.283000   1.000     
1.000   

95001780 O    Grape, raisin                      0.283000   4.700     
1.000   

95001790 O    Grape, wine and sherry             0.283000   1.000     
1.000   

06031820 6C   Guar, seed                         0.010000   1.000     
1.000   

06031821 6C   Guar, seed-babyfood                0.010000   1.000     
1.000   

09011870 9A   Honeydew melon                     0.146000   1.000     
1.000   

95001880 O    Hop                                0.087000   1.000     
1.000   

24001890 M    Horse, meat                        0.020000   1.000     
1.000   

01011900 1AB  Horseradish                        0.046000   1.000     
1.000   

13021910 13B  Huckleberry                        0.168000   1.000     
1.000   

05021940 5B   Kale                               2.014000   1.000     
1.000   

05011960 5A   Kohlrabi                           0.143000   1.000     
1.000   

06032030 6C   Lentil, seed                       0.010000   1.000     
1.000   

04012040 4A   Lettuce, head                      0.066000   1.000     
1.000   

04012050 4A   Lettuce, leaf                      1.946000   1.000     
1.000   

13012080 13A  Loganberry                         0.246000   1.000     
1.000   

11002100 11   Loquat                             0.116000   1.000     
1.000   

28002210 M    Meat, game                         0.020000   1.000     
1.000   

27002220 D    Milk, fat                          0.020000   1.000     
1.000   

27002221 D    Milk, fat - baby food/infant for   0.020000   1.000     
1.000   

27012230 D    Milk, nonfat solids                0.020000   1.000     
1.000   

27012231 D    Milk, nonfat solids-baby food/in   0.020000   1.000     
1.000   

27022240 D    Milk, water                        0.020000   1.000     
1.000   

27022241 D    Milk, water-babyfood/infant form   0.020000   1.000     
1.000   

27032251 D    Milk, sugar (lactose)-baby food/   0.020000   1.000     
1.000   

15002260 15   Millet, grain                      0.011000   1.000     
1.000   

05022290 5B   Mustard greens                     2.014000   1.000     
1.000   

12002300 12   Nectarine                          0.328000   1.000     
1.000   

15002310 15   Oat, bran                          0.011000   1.000     
1.000   

15002320 15   Oat, flour                         0.011000   1.000     
1.000   

15002321 15   Oat, flour-babyfood                0.011000   1.000     
1.000   

15002330 15   Oat, groats/rolled oats            0.011000   1.000     
1.000   

15002331 15   Oat, groats/rolled oats-babyfood   0.011000   1.000     
1.000   

08002340 8    Okra                               0.240000   1.000     
1.000   

04012480 4A   Parsley, leaves                    1.580000   1.000     
1.000   

01012500 1AB  Parsley, turnip rooted             0.046000   1.000     
1.000   

01012510 1AB  Parsnip                            0.046000   1.000     
1.000   

01012511 1AB  Parsnip-babyfood                   0.046000   1.000     
1.000   

06022550 6B   Pea, succulent                     0.010000   1.000     
1.000   

06022551 6B   Pea, succulent-babyfood            0.010000   1.000     
1.000   

06032560 6C   Pea, dry                           0.010000   1.000     
1.000   

06032561 6C   Pea, dry-babyfood                  0.010000   1.000     
1.000   

06012570 6A   Pea, edible podded, succulent      0.010000   1.000     
1.000   

06032580 6C   Pea, pigeon, seed                  0.010000   1.000     
1.000   

06022590 6B   Pea, pigeon, succulent             0.010000   1.000     
1.000   

12002600 12   Peach                              0.328000   1.000     
1.000   

12002601 12   Peach-babyfood                     0.328000   1.000     
1.000   

12002610 12   Peach, dried                       0.328000   7.000     
1.000   

12002611 12   Peach, dried-babyfood              0.328000   7.000     
1.000   

12002620 12   Peach, juice                       0.328000   1.000     
1.000   

12002621 12   Peach, juice-babyfood              0.328000   1.000     
1.000   

11002660 11   Pear                               0.066000   1.000     
1.000   

11002661 11   Pear-babyfood                      0.066000   1.000     
1.000   

11002670 11   Pear, dried                        0.066000   1.000     
1.000   

11002680 11   Pear, juice                        0.066000   1.000     
1.000   

11002681 11   Pear, juice-babyfood               0.066000   1.000     
1.000   

14002690 14   Pecan                              0.011000   1.000     
1.000   

08002700 8    Pepper, bell                       0.240000   1.000     
1.000   

08002701 8    Pepper, bell-babyfood              0.240000   1.000     
1.000   

08002710 8    Pepper, bell, dried                0.240000   1.000     
1.000   

08002711 8    Pepper, bell, dried-babyfood       0.240000   1.000     
1.000   

08002720 8    Pepper, nonbell                    0.240000   1.000     
1.000   

08002721 8    Pepper, nonbell-babyfood           0.240000   1.000     
1.000   

08002730 8    Pepper, nonbell, dried             0.240000   1.000     
1.000   

95002750 O    Peppermint                         1.041000   1.000     
1.000   

95002760 O    Peppermint, oil                    1.041000   0.050     
1.000   

12002850 12   Plum                               0.043000   1.000     
1.000   

12002851 12   Plum-babyfood                      0.043000   1.000     
1.000   

12002860 12   Plum, prune, fresh                 0.043000   1.000     
1.000   

12002861 12   Plum, prune, fresh-babyfood        0.043000   1.000     
1.000   

12002870 12   Plum, prune, dried                 0.043000   5.000     
1.000   

12002871 12   Plum, prune, dried-babyfood        0.043000   5.000     
1.000   

12002880 12   Plum, prune, juice                 0.043000   1.000     
1.000   

12002881 12   Plum, prune, juice-babyfood        0.043000   1.000     
1.000   

25002900 M    Pork, meat                         0.020000   1.000     
1.000   

25002901 M    Pork, meat-babyfood                0.020000   1.000     
1.000   

25002920 M    Pork, meat byproducts              0.020000   1.000     
1.000   

25002921 M    Pork, meat byproducts-babyfood     0.020000   1.000     
1.000   

25002940 M    Pork, kidney                       0.020000   1.000     
1.000   

25002950 M    Pork, liver                        0.020000   1.000     
1.000   

01032960 1C   Potato, chips                      0.309000   1.500     
1.000   

01032970 1C   Potato, dry (granules/ flakes)     0.309000   1.250     
1.000   

01032971 1C   Potato, dry (granules/ flakes)-b   0.309000   1.250     
1.000   

01032980 1C   Potato, flour                      0.309000   1.000     
1.000   

01032981 1C   Potato, flour-babyfood             0.309000   1.000     
1.000   

01032990 1C   Potato, tuber, w/peel              0.309000   1.000     
1.000   

01032991 1C   Potato, tuber, w/peel-babyfood     0.309000   1.000     
1.000   

01033000 1C   Potato, tuber, w/o peel            0.309000   1.000     
1.000   

01033001 1C   Potato, tuber, w/o peel-babyfood   0.309000   1.000     
1.000   

09023080 9B   Pumpkin                            0.136000   1.000     
1.000   

09023090 9B   Pumpkin, seed                      0.136000   1.000     
1.000   

11003100 11   Quince                             0.066000   1.000     
1.000   

29003120 M    Rabbit, meat                       0.020000   1.000     
1.000   

04013130 4A   Radicchio                          0.066000   1.000     
1.000   

01013140 1AB  Radish, roots                      0.086000   1.000     
1.000   

01013160 1AB  Radish, Oriental, roots            0.086000   1.000     
1.000   

05023180 5B   Rape greens                        2.014000   1.000     
1.000   

20003190 20   Rapeseed, oil                      0.011000   1.000     
1.000   

20003191 20   Rapeseed, oil-babyfood             0.011000   1.000     
1.000   

13013200 13A  Raspberry                          0.246000   1.000     
1.000   

13013201 13A  Raspberry-babyfood                 0.246000   1.000     
1.000   

13013210 13A  Raspberry, juice                   0.246000   1.000     
1.000   

13013211 13A  Raspberry, juice-babyfood          0.246000   1.000     
1.000   

04023220 4B   Rhubarb                            0.423000   1.000     
1.000   

15003230 15   Rice, white                        0.011000   1.000     
1.000   

15003231 15   Rice, white-babyfood               0.011000   1.000     
1.000   

15003240 15   Rice, brown                        0.011000   1.000     
1.000   

15003241 15   Rice, brown-babyfood               0.011000   1.000     
1.000   

15003250 15   Rice, flour                        0.011000   1.000     
1.000   

15003251 15   Rice, flour-babyfood               0.011000   1.000     
1.000   

15003260 15   Rice, bran                         0.011000   1.000     
1.000   

15003261 15   Rice, bran-babyfood                0.011000   1.000     
1.000   

01013270 1AB  Rutabaga                           0.086000   1.000     
1.000   

15003280 15   Rye, grain                         0.011000   1.000     
1.000   

15003290 15   Rye, flour                         0.011000   1.000     
1.000   

20003300 20   Safflower, oil                     0.011000   1.000     
1.000   

20003301 20   Safflower, oil-babyfood            0.011000   1.000     
1.000   

01013310 1AB  Salsify, roots                     0.046000   1.000     
1.000   

26003390 M    Sheep, meat                        0.020000   1.000     
1.000   

26003391 M    Sheep, meat-babyfood               0.020000   1.000     
1.000   

26003400 M    Sheep, meat byproducts             0.020000   1.000     
1.000   

26003420 M    Sheep, kidney                      0.020000   1.000     
1.000   

26003430 M    Sheep, liver                       0.020000   1.000     
1.000   

15003440 15   Sorghum, grain                     0.011000   1.000     
1.000   

15003450 15   Sorghum, syrup                     0.011000   1.000     
1.000   

06003470 6    Soybean, seed                      0.010000   1.000     
1.000   

06003480 6    Soybean, flour                     0.010000   1.000     
1.000   

06003481 6    Soybean, flour-babyfood            0.010000   1.000     
1.000   

06003490 6    Soybean, soy milk                  0.010000   1.000     
1.000   

06003491 6    Soybean, soy milk-babyfood or in   0.010000   1.000     
1.000   

06003500 6    Soybean, oil                       0.010000   1.000     
1.000   

06003501 6    Soybean, oil-babyfood              0.010000   1.000     
1.000   

95003520 O    Spearmint                          1.041000   1.000     
1.000   

95003530 O    Spearmint, oil                     1.041000   0.050     
1.000   

04013550 4A   Spinach                            1.580000   1.000     
1.000   

04013551 4A   Spinach-babyfood                   1.580000   1.000     
1.000   

09023560 9B   Squash, summer                     0.136000   1.000     
1.000   

09023561 9B   Squash, summer-babyfood            0.136000   1.000     
1.000   

09023570 9B   Squash, winter                     0.136000   1.000     
1.000   

09023571 9B   Squash, winter-babyfood            0.136000   1.000     
1.000   

95003590 O    Strawberry                         0.266000   1.000     
1.000   

95003591 O    Strawberry-babyfood                0.266000   1.000     
1.000   

95003600 O    Strawberry, juice                  0.266000   1.000     
1.000   

95003601 O    Strawberry, juice-babyfood         0.266000   1.000     
1.000   

20003640 20   Sunflower, seed                    0.011000   1.000     
1.000   

20003650 20   Sunflower, oil                     0.011000   1.000     
1.000   

20003651 20   Sunflower, oil-babyfood            0.011000   1.000     
1.000   

01033660 1CD  Sweet potato                       0.011000   1.000     
1.000   

01033661 1CD  Sweet potato-babyfood              0.011000   1.000     
1.000   

04023670 4B   Swiss chard                        0.423000   1.000     
1.000   

01033710 1CD  Tanier, corm                       0.011000   1.000     
1.000   

08003740 8    Tomatillo                          0.180000   1.000     
1.000   

08003750 8    Tomato                             0.180000   1.000     
1.000   

08003751 8    Tomato-babyfood                    0.180000   1.000     
1.000   

08003760 8    Tomato, paste                      0.180000   3.800     
1.000   

08003761 8    Tomato, paste-babyfood             0.180000   3.800     
1.000   

08003770 8    Tomato, puree                      0.180000   1.000     
1.000   

08003771 8    Tomato, puree-babyfood             0.180000   1.000     
1.000   

08003780 8    Tomato, dried                      0.180000  14.300     
1.000   

08003781 8    Tomato, dried-babyfood             0.180000  14.300     
1.000   

08003790 8    Tomato, juice                      0.180000   1.000     
1.000   

15003810 15   Triticale, flour                   0.011000   1.000     
1.000   

15003811 15   Triticale, flour-babyfood          0.011000   1.000     
1.000   

01033870 1CD  Turmeric                           0.011000   1.000     
1.000   

01013880 1AB  Turnip, roots                      0.086000   1.000     
1.000   

05023890 5B   Turnip, greens                     2.014000   1.000     
1.000   

86010000 O    Water, direct, all sources         0.012300   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.012300   1.000     
1.000   

09013990 9A   Watermelon                         0.146000   1.000     
1.000   

09014000 9A   Watermelon, juice                  0.146000   1.000     
1.000   

15004010 15   Wheat, grain                       0.011000   1.000     
1.000   

15004011 15   Wheat, grain-babyfood              0.011000   1.000     
1.000   

15004020 15   Wheat, flour                       0.011000   1.000     
1.000   

15004021 15   Wheat, flour-babyfood              0.011000   1.000     
1.000   

15004030 15   Wheat, germ                        0.011000   1.000     
1.000   

15004040 15   Wheat, bran                        0.011000   1.000     
1.000   

15004050 15   Wild rice                          0.011000   1.000     
1.000   

01034060 1CD  Yam, true                          0.011000   1.000     
1.000   

01034070 1CD  Yam bean                           0.011000   1.000     
1.000   

Attachment 2.  Summary of the acute dietary exposure analysis for
thiamethoxam.

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for THIAMETHOXAM                       
(1994-98 data)

Residue file: 060109 2006 Acute T + C from T + Water no CT.R98

Adjustment factor #2 NOT used.

Analysis Date: 01-23-2007/13:51:05    Residue file dated:
01-23-2007/13:48:49/8

Daily totals for food and foodform consumption used.

Run Comment: "Acute and Chronic RfDs = aPAD and cPAD"

========================================================================
=======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
--------

U.S. Population:

                    0.004698     1.34    0.008688     2.48    0.016569  
  4.73 

All infants:

                    0.009228     2.64    0.019340     5.53    0.032703  
  9.34 

Children 1-2 yrs:

                    0.011707     3.34    0.019173     5.48    0.045434  
 12.98 

Children 3-5 yrs:

                    0.008783     2.51    0.013907     3.97    0.027117  
  7.75 

Children 6-12 yrs:

                    0.005098     1.46    0.007808     2.23    0.012387  
  3.54 

Youth 13-19 yrs:

                    0.003206     0.92    0.006809     1.95    0.012119  
  3.46 

Adults 20-49 yrs:

                    0.003069     0.88    0.005561     1.59    0.010703  
  3.06 

Adults 50+ yrs:

                    0.003403     0.97    0.006234     1.78    0.010762  
  3.07 

Females 13-49 yrs:

                    0.003151     0.90    0.005606     1.60    0.010954  
  3.13 

Attachment 3.  Summary of the chronic dietary exposure analysis for
thiamethoxam.

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for THIAMETHOXAM                     (1994-98
data)

Residue file name: C:\Documents and Settings\mdoherty\My
Documents\Chemistry Reviews\DEEM Runs\Clothianidin and
Thiamethoxam\Thiamethoxam\060109 2006 Acute T + C from T + Water no
CT.R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 01-23-2007/13:49:26     Residue file dated:
01-23-2007/13:48:49/8

Reference dose (RfD, Chronic) = .012 mg/kg bw/day

COMMENT 1: Acute and Chronic RfDs = aPAD and cPAD

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.001630               
13.6%

U.S. Population (spring season)             0.001619               
13.5%

U.S. Population (summer season)             0.001705               
14.2%

U.S. Population (autumn season)             0.001604               
13.4%

U.S. Population (winter season)             0.001592               
13.3%

Northeast region                            0.001664               
13.9%

Midwest region                              0.001633               
13.6%

Southern region                             0.001532               
12.8%

Western region                              0.001753               
14.6%

Hispanics                                   0.001671               
13.9%

Non-hispanic whites                         0.001591               
13.3%

Non-hispanic blacks                         0.001686               
14.0%

Non-hisp/non-white/non-black                0.002029               
16.9%

All infants (< 1 year)                      0.003298               
27.5%

Nursing infants                             0.001526               
12.7%

Non-nursing infants                         0.003970               
33.1%

Children 1-6  yrs                           0.003996               
33.3%

Children 7-12 yrs                           0.001962               
16.4%

Females 13-19 (not preg or nursing)         0.001194                
9.9%

Females 20+ (not preg or nursing)           0.001305               
10.9%

Females 13-50 yrs                           0.001325               
11.0%

Females 13+ (preg/not nursing)              0.001357               
11.3%

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               13.2%

Males 13-19 yrs                             0.001371               
11.4%

Males 20+ yrs                               0.001262               
10.5%

Seniors 55+                                 0.001373               
11.4%

Children 1-2 yrs                            0.005005               
41.7%

Children 3-5 yrs                            0.003718               
31.0%

Children 6-12 yrs                           0.002092               
17.4%

Youth 13-19 yrs                             0.001285               
10.7%

Adults 20-49 yrs                            0.001245               
10.4%

Adults 50+ yrs                              0.001361               
11.3%

Females 13-49 yrs                           0.001248               
10.4%

------------------------------------------------------------------------
-------

Thiamethoxam	Dietary Exposure and Risk Assessment	DP Number:  335846

PC Code:  060109

Page   PAGE  3  of   NUMPAGES  15