Document ID: EPA-HQ-OPP-2007-0105-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2007-11-28T05:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF           

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM

	Date:	11/5/2004

	Subject:	Acetamiprid.  Tolerance Petition Requesting Section 3
Registration for Food Use of the Insecticide Acetamiprid on Cucurbit
Vegetables (Crop Group 9), Stone Fruits (Crop Group 12), and Tree Nuts
(Crop Group 14).  Summary of Analytical Chemistry and Residue Data. 
Petition Number 4F6833.  

		DP Number:	303623	Decision Number:	342506

		PC Code:	099050	Trade Name:	Assail( 70WP

		40 CFR 180.	578	MRID Numbers:	46265701, 46265702, 46265703

	From:	William T. Drew, Chemist

		Registration Action Branch 2

		Health Effects Division (7509C)

	Through:	Michael Doherty, Acting Branch Senior Scientist

		Registration Action Branch 2

		Health Effects Division (7509C)

	To:	Akiva Abramovitch/John Hebert, PM Team 07

		Insecticide/Rodenticide Branch

		Registration Division (7505C)

This document was originally prepared under contract by Dynamac
Corporation (20440 Century Boulevard, Suite 100; Germantown, MD 20874);
it has been reviewed by the HED and revised to reflect current OPP
policies.

Executive Summary

The petitioner, Nisso America Incorporated (representing Nippon Soda
Company Limited, which acquired the registrations for acetamiprid from
Aventis CropScience), has requested a Section 3 registration and
proposed, in PP#4F6833, the establishment of permanent tolerances for
residues of the insecticide acetamiprid arising from its use on cucurbit
vegetables, stone fruits, and tree nuts.  Nisso has proposed permanent
tolerances, as listed below, in/on the following raw agricultural and
processed commodities:

cucurbit vegetables (Crop Group 9)	0.5 ppm,

stone fruits (Crop Group 12), except prune plum	1.2 ppm,

prune plum, fresh and dried	0.3 ppm,

tree nuts (Crop Group 14)	0.1 ppm,

almond hulls	5.0 ppm.

Acetamiprid, a selective insecticide with CAS registry number
135410-20-7 and the CAS name (1E)-N-[(6-chloro-3-pyridinyl)methyl]-N
'-cyano-N-methylethanimidamide, belongs to the chloronicotinyl
(neonicotinoid) class of chemical compounds.  In conjunction with the
subject petition, Nisso has submitted an application for an amended
Section 3 registration on a wettable powder (WP) formulation of
acetamiprid (Assail( 70WP, EPA Registration Number 8033-23) comprised of
70% active ingredient (ai) to control aphids, leafhoppers, and other
sucking/chewing pests on cucurbits, stone fruits, and tree nuts.  The
proposed maximum seasonal rates are 0.50 to 0.72 pound active ingredient
per acre (lb ai/A) when applied as a foliar broadcast spray using aerial
or ground equipment.  The proposed pre-harvest intervals (PHIs) are 0
days for cucurbit vegetables, 7 days for stone fruits, and 14 days for
tree nuts.  The product is currently registered for foliar application
to cotton, leafy vegetables, cole vegetables, fruiting vegetables,
citrus fruits, pome fruits, and grapes, and for seed treatment of canola
and mustard seed.  Pending applications to include the use of
acetamiprid on tuberous and corm vegetables (Crop Subgroup 1C) and
tobacco are under separate review (PP#3F6575).  This previous
acetamiprid petition was submitted by Aventis CropScience; since that
time, Nippon Soda Company Limited has taken over ownership of
acetamiprid registrations.

Tolerances for acetamiprid are listed below as seen in 40 CFR §180.578
(utilizing IUPAC nomenclature).  

(a) General. (1) Tolerances are established for residues of the
insecticide acetamiprid,
N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine, in or on
the following commodities: 

----------------------------------------------------------------- 

Commodity				Parts per million 

-----------------------------------------------------------------

 ADVANCE \d4 Canola, seed..............................................
0.010 Citrus, dried pulp........................................ 1.20
Cotton, gin byproducts.................................... 20.0 Cotton,
undelinted seed................................... 0.60 Fruit, citrus
group....................................... 0.50 Fruit, pome
group......................................... 1.0
Grape..................................................... 0.20 Mustard,
seed............................................. 0.010 Tomato,
paste............................................. 0.40 Vegetable,
brassica, leafy, group 5....................... 1.20 Vegetable,
fruiting, group 8.............................. 0.20 Vegetable, leafy,
except brassica, group 4................ 3.00 

----------------------------------------------------------------- 

 ADVANCE \d4 (2) Tolerances are established for the combined residues of
the insecticide acetamiprid,
N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine, and
metabolite, N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-acetamidine, in or
on the following commodities: 

----------------------------------------------------------------- 
ADVANCE \d4 			Commodity 				Parts per million 

-----------------------------------------------------------------

 ADVANCE \d4 Cattle, fat..............................................
0.10 Cattle, meat............................................. 0.10
Cattle, meat byproducts.................................. 0.20
Egg...................................................... 0.010 Goat,
fat................................................ 0.10 Goat,
meat............................................... 0.10 Goat, meat
byproducts.................................... 0.20 Hog,
fat................................................. 0.10 Hog,
meat................................................ 0.10 Hog, meat
byproducts..................................... 0.20 Horse,
fat............................................... 0.10 Horse,
meat.............................................. 0.10 Horse, meat
byproducts................................... 0.20
Milk..................................................... 0.10 Poultry,
fat............................................. 0.010 Poultry,
liver........................................... 0.050 Poultry,
meat............................................ 0.010 Sheep,
fat............................................... 0.10 Sheep,
meat.............................................. 0.10 Sheep, meat
byproducts................................... 0.20 

----------------------------------------------------------------- 	The
HED Metabolism Assessment Review Committee (MARC) has determined that
the nature of the residue in plants and animals is adequately
understood.  It was concluded that the tolerance expression should
include acetamiprid per se for plant commodities and combined residues
of acetamiprid and IM-2-1 for livestock commodities.  In addition,
residues of IM-2-1-amide, with IUPAC name N 2-aminocarbonyl-N
1-[(6-chloro-3-pyridyl)methyl]acetamidine, in ruminant muscle tissue
should be included in the risk assessment for acetamiprid.  Residues of
IM-2-1-amide were not measured as part of the ruminant feeding study;
however, data indicate that residues of IM-2-1-amide in ruminant muscle
tissue can be estimated by applying a 10-fold factor to residues of
IM-2-1 in muscle.  In the original petition, HED suggested to the
petitioner that a hydrolysis step be included in the method to convert
IM-2-1-amide to IM-2-1.  

Adequate crop field trial data have been submitted reflecting the
proposed uses on cucurbit vegetables, stone fruits, and tree nuts.  The
studies are supported by adequate storage stability data.  Adequate
processing data have been submitted for plum which indicate that a
separate tolerance is needed for dried prune plum.  Adequate residue
analytical methods are available for the enforcement of established and
proposed tolerances for plant commodities (GC/ECD and HPLC/UV) and
animal commodities (HPLC/UV).  These methods were submitted to the
Analytical Chemistry Branch of the Biological and Economic Analysis
Division (ACB/BEAD) for petition method validation (PMV) and were
ultimately validated.  However, the registrant has subsequently proposed
that the HPLC/MS/MS method utilized for data collection (in PP#3F6575
and PP#4F6833) replace the current tolerance enforcement method (GC/ECD)
for those plant commodities proposed in PP#4F6833.  An independent
laboratory validation (ILV) for this method has not been submitted and
so, as a condition of registration, the proposed enforcement method must
undergo ILV, and possibly be submitted to ACB/BEAD for PMV (it should be
noted that the HPLC/MS/MS method must analyze a minimum of two daughter
ions specific to acetamiprid if it is to be considered acceptable as
both a tolerance enforcement and confirmatory method).  Adequate cattle
feeding study data are available to support the proposed uses of
acetamiprid.  No poultry feed items are associated with this petition. 
There are currently no established Codex or Canadian MRLs for
acetamiprid.  One Mexican MRL is established for acetamiprid on cotton
seed at 0.01 mg/kg.

Regulatory Recommendations and Residue Chemistry Deficiencies

HED has examined the residue chemistry database for acetamiprid.  A
human health risk assessment is being prepared as a separate document. 
Pending resolution of the deficiencies noted below, and provided the
proposed HPLC/MS/MS enforcement analytical method receives a
satisfactory ILV, there are no residue chemistry issues that would
preclude granting a conditional registration for this insecticide on the
proposed uses or establishment of tolerances for acetamiprid per se as
follows:

cucurbit vegetables (Crop Group 9)	0.50 ppm,

stone fruits (Crop Group 12), except prune plum	1.20 ppm,

fresh prune plum	0.20 ppm,

dried prune plum	0.40 ppm,

tree nuts (Crop Group 14)	0.10 ppm,

pistachio	0.10 ppm,

almond hulls	5.0 ppm.

860.1340 Residue Analytical Method - Plant Commodities

The proposed  HPLC/MS/MS enforcement method for plant commodities must
undergo ILV as a condition of registration, and possibly PMV (it should
be noted that the HPLC/MS/MS method must analyze a minimum of two
daughter ions specific to acetamiprid if it is to be considered
acceptable as both a tolerance enforcement and confirmatory method).

860.1850 Confined Rotational Crops

The available rotational crop data, submitted in conjunction with the
original petition (PP#0F6082, DP Barcode D264154, 12/31/01, M. Doherty),
are adequate to support the uses requested in this petition.  However,
submission of the outstanding rotational crop supporting storage
stability data, which were required as a  condition of registration in
the original petition, should be a condition of the registration
requested in this review.

860.1550 Proposed Tolerances

The available stone fruit group crop field trial data indicate that the
proposed tolerance for fresh prune plum is too high, while that for
dried prune plum is too low; a tolerance of 0.20 ppm would be
appropriate for fresh prune plum and 0.40 ppm would be appropriate for
dried prune plum.  The tolerance for stone fruits (Crop Group 12),
except prune plum, should be stated as 1.20 ppm rather than 1.2 ppm.  A
separate tolerance for pistachio must be proposed at the same level as
the tree nut group tolerance.  The proposed tolerances should be revised
to reflect the correct commodity definitions as specified in Table 6; a
revised Section F should be submitted to incorporate all of these
changes.

Background

Nisso has petitioned the Agency to register the Assail( 70WP formulation
of the insecticide acetamiprid, with CAS name
(1E)-N-[(6-chloro-3-pyridinyl)methyl]-N '-cyano-N-methylethanimidamide,
on members of the cucurbit vegetable crop group, the stone fruit crop
group, the tree nut crop group (including pistachio), and almond hulls. 
Acetamiprid is currently registered for foliar application to cotton,
leafy vegetables, cole vegetables, fruiting vegetables, citrus fruits,
pome fruits, and grapes, and for seed treatment of canola and mustard
seed.  The existing registrations were reviewed by HED under the
original petition (PP#0F6082, DP Barcode D264154, 12/31/01, M. Doherty).
 Pending applications to include the use of acetamiprid on tuberous and
corm vegetables (Crop Subgroup 1C) and tobacco are under separate review
(PP#3F6575).  

Acetamiprid is an insecticide intended for use against various insect
pests that feed upon fruit and vegetable crops.  It is a member of the
chloronicotinyl (neonicotinoid) class of insecticides, which function by
binding to nicotinic acetylcholine receptors in the post-synaptic
neurons of the insect’s central nervous system.  This binding results
in the opening of ion pores, causing a subsequent overload of sodium
ions in the neurons which leads to nervous system hyper-excitation and
eventual death of the insect.  For use on the crops requested,
acetamiprid is formulated as Assail( 70WP (EPA Registration Number
8033-23), a wettable powder comprised of 70% ai by weight.

The chemical structure and nomenclature of acetamiprid and its
metabolites, and the physicochemical properties of the technical grade
of acetamiprid are presented in Tables 1 and 2, below. 



TABLE 1.	Test Compound Nomenclature

Compound	

Chemical Structure

Common Name	

Acetamiprid

Company Experimental Name	

EXP-61842A, AEF124370, NI-25

IUPAC Name	

(E)-N 1-[(6-chloro-3-pyridyl)methyl]-N 2-cyano-N 1-methylacetamidine

CAS Name	

(1E)-N-[(6-chloro-3-pyridinyl)methyl]-N'-cyano-N-methylethanimidamide

CAS #	

135410-20-7

End-Use Product	

Assail( 70WP

Chemical structure of acetamiprid metabolite IM-2-1	

N 1-[(6-chloro-3-pyridyl)methyl]-N 2-cyano-acetamidine

Chemical structure of acetamiprid metabolite IM-2-1-amide

(also referred to as IM-2-2)	

N 2-aminocarbonyl-N 1-[(6-chloro-3-pyridyl)methyl]acetamidine



TABLE 2.	Physicochemical Properties of Technical Grade Acetamiprid.

Parameter	

Value	

Reference

Melting Point ((C)	

98.9	

D264154, 12/31/01, M. Doherty

pH (20(C)	

6.08 (Aqueous Solution)	

Section A of PP#4F6833

Density (20(C)	

1.33 g/cm3	

D264154, 12/31/01, M. Doherty

Water Solubility (25(C)	

4.25 g/L (4250 ppm)	

D264154, 12/31/01, M. Doherty

Solvent Solubility (25(C)	

Acetone	>20 g/100 g

Methanol	>20 g/100 g

Ethanol	>20 g/100 g

Dichloromethane	>20 g/100 g

Chloroform	>20 g/100 g

Acetonitrile	>20 g/100 g

Tetrahydrofuran	>20 g/100 g

Benzene	2.44 g/100 g

Xylene	4.01 g/100 g

n-Hexane	6.54 ppm

Carbon Disulfide	507 ppm	

Section A of PP#4F6833

Vapor Pressure (25(C)	

7.5 x 10-9 mm Hg	

D264154, 12/31/01, M. Doherty

Dissociation Constant, pKa (25(C)	

0.7	

Section A of PP#4F6833

Octanol/Water Partition Coefficient, 

Log KOW (25(C)	

0.8	

Section A of PP#4F6833

UV/Visible Absorption Spectrum	

(Not available)	

860.1200  Directions for Use

The use directions for the crops requested in PP#4F6833 are summarized
in Table 3, below.



Table 3.	Summary of Directions for Use of Acetamiprid.

Trade Name	

Application Timing; Type; and Equipment	

Application Rate	

Maximum Number of Applications/ Season	

Maximum Seasonal Application Rate

(lb ai/A)	

PHI1 (Days)	

Use Directions and Limitations

Cucurbits crop group including chayote (fruit), Chinese waxgourd
(Chinese preserving melon), citron melon, cucumber, gherkin, gourd
(edible), Mormordica spp., muskmelon (hybrid and/or cultivars of Cucumis
melo), pumpkin, squash (summer and winter), and watermelon.

Assail( 70WP Insecticide	

Pest-dependent; broadcast foliar;

ground or aerial	

0.05-0.10	

5	

0.50	

0	

Applications made in minimum spray volume of 5 gallons per acre (GPA)
for aerial equipment or 20 GPA for ground equipment; 5-day minimum RTI2.

Stone fruit crop group including apricot, cherry (sweet and tart),
nectarine, peach, plum (chickasaw, damson, Japanese), plumcot, and prune
(fresh).

Assail( 70WP Insecticide	

Pest-dependent; broadcast foliar;

ground or aerial	

0.05-0.15	

4	

0.60	

7	

Applications made in minimum spray volume of 10 GPA for aerial equipment
or 50 GPA for ground equipment; 10-day minimum RTI. 

Tree nuts crop group including almond, beech nut, Brazil nut, butternut,
cashew, chestnut, chinquapin, filbert (hazelnut), hickory nut, macadamia
(bush nut), pecan, pistachio, and walnut (black and English [Persian]).

Assail( 70WP Insecticide	

Pest-dependent; broadcast foliar;

ground or aerial	

0.05-0.18	

4	

0.72	

14	

Applications made in minimum spray volume of 10 GPA for aerial equipment
or 50 GPA for ground equipment; 7-day minimum RTI.

1. PHI = Pre-Harvest Interval.

2. RTI = Re-Treatment Interval.

Application through any type of irrigation system is prohibited.  The
proposed label recommends that applications of different chemical
classes should be alternated to reduce the potential for pest resistance
development.  No rotational crop restrictions have been proposed.  For
orchard and vineyard crops, the proposed label states that the use of
high quality non-ionic surfactants or horticultural oils may improve
pest control; this statement is also included in the specific use
directions for cotton, citrus fruits, pome fruits, stone fruits, and
tree nuts.  The proposed label was adequate to allow evaluation of the
residue data submitted in support of this petition, relative to the
proposed uses. 

860.1300 Nature of the Residue - Plants

MARC Decision Memorandum, D278652, Michael Doherty, 11/13/2001

DERs: Apple, MRID 44988520; Cabbage, MRID 44988522; Carrot, MRID
44988519; Cotton, MRID 44988518; Eggplant, MRID 44988521

No plant metabolism studies were submitted with the subject petition. 
Acceptable plant metabolism studies with acetamiprid on apple, cabbage,
carrot, cotton, and eggplant were submitted as part of the data package
for the original acetamiprid petition (PP#0F6082, D264154, 12/31/01, M.
Doherty).  It was found that in most plants, acetamiprid is demethylated
at the N1 amine to form IM-2-1 which may then be further metabolized to
form IM-0 and IC-0.  IM-0 is then metabolized to form the glucose
conjugate IM-0-Glc.  HED concluded that the submitted studies were
adequate to delineate the qualitative nature of the residue in the crops
proposed for use in that petition.  The MARC determined that for both
tolerance expression and risk assessment purposes, the residue of
concern was acetamiprid per se.

The available plant metabolism data are adequate to support the proposed
uses on cucurbit vegetables, stone fruits, and tree nuts.  The residue
of concern in these commodities is acetamiprid per se.

860.1300 Nature of the Residue - Livestock

MARC Decision Memorandum, D278652, Michael Doherty, 11/13/2001

DERs: Lactating Goat, MRID 44988524; Laying Hen, MRID 44988523

No animal metabolism studies were submitted with the current petition. 
Adequate metabolism studies with acetamiprid in ruminants and laying
hens were submitted in conjunction with the original petition
(PP#0F6082, D264154, 12/31/01, M. Doherty).  It was found that
acetamiprid is metabolized in goats via loss of an amine methyl group,
forming IM-2-1, which can be further hydrolyzed to form IM-2-3 and
IM-2-4.  IM-2-1-amide (IM-2-2) can be formed as an intermediate in the
metabolism of IM-2-1 to IM-2-4.  In poultry, IM-2-1-amide can be
converted to IM-2-5 through loss of the acetamide group. 

HED has concluded that the qualitative nature of acetamiprid residues in
livestock is adequately understood.  The MARC determined that the
tolerance expression for livestock commodities should be acetamiprid
plus its IM-2-1 metabolite.  For purposes of risk assessment, the
residues of concern in livestock tissue (except ruminant muscle) are
acetamiprid plus its IM-2-1 metabolite.  In ruminant muscle, the
residues of concern for risk assessment are acetamiprid plus IM-2-1 plus
IM-2-1-amide.  Residues of IM-2-1-amide in ruminant muscle tissue can be
estimated by applying a 10-fold factor to residues of IM-2-1 in muscle

860.1340 Residue Analytical Methods

DERs: Cucurbits, MRID 46265701; Stone Fruits, MRID 46265702; Tree Nuts,
MRID 46265703

Enforcement methods  The petitioner submitted three analytical methods
for acetamiprid in conjunction with the original petition (PP#0F6082,
D264154, 12/31/01, M. Doherty).  The methods and their performance are
summarized in Table 4, below.  Adequate ILV data were submitted.  The
citrus and livestock methods were successfully radiovalidated for
acetamiprid (minimum 85% recovery) using samples from the metabolism
studies.  Because the methods include instructions for confirmation of
residues of acetamiprid and IM-2-1 using HPLC/MS/MS determination,
interference testing was not required.  The methods were submitted to
the ACB/BEAD for PMV; the GC/ECD method (with spinach) and the HPLC/UV
method (with milk) were ultimately validated.  

The petitioner originally stated that the enforcement method for
vegetables and non-citrus fruits (GC/ECD method) was to be used for
enforcement of the proposed tolerances for acetamiprid residues in/on
cucurbit vegetables, stone fruits, and tree nuts, but has subsequently
proposed that the HPLC/MS/MS method that was used for data collection in
the current petition be adopted as the tolerance enforcement method for
the requested crops (and apparently for vegetables and non-citrus
fruits, as well).  Therefore, as a condition of registration, this
method must undergo successful ILV to be adopted as the tolerance
enforcement method (it should be noted that the HPLC/MS/MS method must
analyze a minimum of two daughter ions specific to acetamiprid if it is
to be considered acceptable as both a tolerance enforcement and
confirmatory method).

Table 4.	Summary of Validated Analytical Methods for Acetamiprid.

Target Matrices	

Method Description	

LOQ (ppm)	

Method Validation

	

Fortification Levels, ppm	

Recovery Range, %

Vegetables and Non-Citrus Fruits	

Methanol extraction, residues partitioned into dichloromethane,
Florisil/silica gel column cleanup, and GC/ECD determination.	

0.010	

0.010, 0.050	

68-112

Citrus Fruits	

Acetonitrile extraction, coextractives partitioned into hexane, residues
partitioned into dichloromethane, Florisil/C18 column cleanup, and
HPLC/UV determination.	

0.050	

0.050, 0.250	

77-100

Eggs, Milk, and Ruminant and Poultry Tissues	

Acetonitrile extraction, residues partitioned into dichloromethane,
Florisil/C18 column cleanup, and HPLC/UV determination.  The method
determines both acetamiprid and IM-2-1.	

0.010 ppm (muscle, fat, milk, and eggs)	

0.010, 0.100	

78-103 (acetamiprid)

81-109 (IM-2-1)

0.050 ppm 

(liver and kidney)	

0.050, 0.500

	

Data collection methods  Samples from the crop field trial and
processing studies submitted in conjunction with this petition were
analyzed for residues of acetamiprid using HPLC/MS/MS method KP-216R0,
entitled Preliminary LC/MS/MS Analytical Method for Determination of
ASSAIL( 70WP Insecticide (Acetamiprid) in Crop Matrices or its modified
version, KP-216R1.  Briefly, homogenized samples were extracted with
methanol:water (1:1 vol/vol), centrifuged, and filtered.  The extracts
were combined, the volume was adjusted with methanol:water (25:75
vol/vol), and the extract was cleaned up by solid phase extraction
(Oasis HLB column); residues were eluted with acetonitrile.  Following
purification, the extract was filtered for HPLC/MS/MS analysis. 
HPLC/MS/MS analysis was conducted using a C8 column, a gradient mobile
phase of methanol and 1% formic acid in water, and MS/MS detection in
the positive-ion mode; only one daughter ion was analyzed.  The limit of
quantitation (LOQ) was 0.010 ppm in cucurbit vegetables, stone fruits,
and almond and pecan nutmeat, and 0.020 ppm in almond hulls.  Adequate
concurrent method recovery data were submitted for cucurbit vegetables
(cucumbers, muskmelons, and summer squash), stone fruits (sweet and tart
cherry, peach, and plum), and tree nuts (almond and pecan nutmeat, and
almond hulls).

Although the method used for data collection (HPLC/MS/MS) differs from
the proposed enforcement method (GC/ECD), HED concludes that the method
is adequate for the purposes of data collection to support the proposed
tolerances.  The solvent extraction steps are similar in both methods
(methanol extraction in GC/ECD method; methanol/water extraction in
HPLC/MS/MS method), and the results of concurrent method recovery
analyses indicate that residues of acetamiprid are not lost during the
cleanup steps of the HPLC/MS/MS method.  

860.1360 Multiresidue Methods

DER: MRID 44988534

The petitioner submitted data concerning the recovery of residues of
acetamiprid using FDA multiresidue method protocols (PAM Volume I) in
conjunction with the original petition (PP#0F6082, D264154, 12/31/01, M.
Doherty).  These data have been forwarded to FDA for evaluation.  Based
on the results of the testing, the multiresidue methods are not
appropriate for determining acetamiprid residues of concern.  BEAD is
currently working on a multi-residue method for the neonicitinoids.

860.1380 Storage Stability

DERs: Various Commodities, MRID 44988535; Cucurbits, MRID 46265701;
Stone Fruits, MRID 46265702; Tree Nuts, MRID 46265703

The petitioner did not conduct storage stability studies in conjunction
with the submitted field trial and processing studies.  Instead, storage
stability data generated in conjunction with PP#0F6082 (MRID 44988535;
D264154, 12/31/01, M. Doherty) were referenced.  These data demonstrated
that residues of acetamiprid were relatively stable under frozen storage
conditions in/on fortified samples of whole apple, apple juice, wet
apple pomace, cabbage, cotton seed, cotton gin byproducts, cotton seed
hulls, cotton seed meal, cotton seed oil, cucumber, head lettuce, whole
orange, orange juice, orange oil, and orange dried pulp for up to 12
months (up to 15 months for head lettuce).

In addition, the stability of acetamiprid during short-term storage at
ambient temperatures was evaluated.  Samples of cotton seed, cotton gin
trash, cotton seed oil, whole grapes, grape juice, raisins, whole
oranges, whole tomatoes, and tomato paste spiked with acetamiprid at
0.10 and 0.25 ppm were stored at ambient temperatures for a duration of
7 days (15 days for raisins).  Under these conditions, residues of
acetamiprid were stable in all commodities.  

The maximum storage durations of residue study crop samples from harvest
to analysis were 137 days (4.5 months) for cucurbit vegetables, 116 days
(3.8 months) for stone fruits, 161 days (5.3 months) for tree nut
nutmeat, 139 days (4.6 months) for almond hulls, and 62 days (2.0
months) for dried prunes. 

The available storage stability data are sufficient to be
representative of the current and proposed uses of acetamiprid.  The
data represent an oilseed (cotton seed), a leafy vegetable (head
lettuce), a Brassica leafy vegetable (cabbage), a cucurbit vegetable
(cucumber), and fruits (apple and orange), as well as the processed
commodities of apple, cotton, and orange.  The available storage
stability data are adequate and may be translated to support the storage
conditions and durations for all samples from the submitted cucurbit
vegetable, stone fruit, and tree nut field trials and plum processing
study.

860.1480 Meat, Milk, Poultry, and Eggs

DERs: Cattle, MRID 44988601; Poultry, MRID 44988602; Tree Nuts, MRID
46265703

No new animal feeding studies were submitted with this petition.  The
only cattle feedstuff associated with this petition is almond hulls. 
Previously (PP#0F6082, D264154, 12/31/01, M. Doherty), the maximum
theoretical dietary burden of acetamiprid to beef and dairy cattle was
estimated to be 4.5 ppm, based on a diet consisting of cotton gin
byproducts (20% in diet, 90% dry matter, 20 ppm tolerance) and cotton
seed meal (15% in diet, 89% dry matter, cotton seed tolerance of 0.6
ppm).  The proposed use of acetamiprid on almonds is not likely to
increase the dietary burden, considering that cotton gin byproducts are
the major contributor to the dietary burden and that cattle are not
likely to be fed a diet consisting of both cotton commodities and almond
hulls.  The tolerances established in 40 CFR §180.578(a)(2) for milk
and the fat, meat, and meat byproducts of cattle, goat, hog, horse, and
sheep are adequate to cover any secondary transfer of the residues of
concern as a result of the proposed new uses.

There are no poultry feedstuffs associated with this petition;
therefore, the potential for residues in poultry commodities does not
need to be addressed.

860.1500 Crop Field Trials

DERs: Cucurbits, MRID 46265701; Stone Fruits, MRID 46265702; Tree Nuts,
MRID 46265703

Table 5.	Summary of Residues from Crop Field Trials with Acetamiprid.

Crop Matrix	

Total Application Rate 

(lb ai/A)	

PHI (Days) 	

Spray Volume 1	

Residues of Acetamiprid (ppm) 2

n	

Min.	

Max.	

HAFT	

Median	

Mean	

Std. Dev.

Cucurbit Vegetable Group 9 (proposed use = 0.50 lb ai/A total
application rate, 0-day PHI)

Cucumber	

0.496-0.508	

0	

--	

12	

0.015	

0.091	

0.086	

0.028	

0.037	

0.025

Muskmelon	

0.500-0.502	

0	

--	

12	

0.011	

0.142	

0.103	

0.036	

0.051	

0.039

Summer Squash	

0.502-0.508	

0	

--	

10	

0.004	

0.221	

0.194	

0.083	

0.098	

0.062

Stone Fruit Group 12 (proposed use = 0.6 lb ai/A total application rate,
7-day PHI)

Cherry	

0.591-0.606	

7	

dilute	

12	

0.251	

0.932	

0.878	

0.448	

0.528	

0.213

	

0.590-0.595	

7	

concentrate	

8	

0.079	

0.767	

0.708	

0.491	

0.444	

0.238

Peach	

0.585-0.596	

7-8	

dilute	

16	

0.093	

0.387	

0.335	

0.196	

0.214	

0.081

	

0.589-0.600	

7	

concentrate	

10	

0.153	

0.565	

0.438	

0.208	

0.244	

0.122

Plum	

0.591-0.592	

7	

dilute	

8	

0.014	

0.116	

0.112	

0.046	

0.057	

0.038

	

0.588-0.597	

7	

concentrate	

8	

0.010	

0.119	

0.092	

0.039	

0.045	

0.035

Tree Nut Group 14 (proposed use = 0.72 lb ai/A total application rate,
14-day PHI)

Almond Hulls	

0.713-0.720	

14	

dilute	

6	

1.45	

4.03	

3.83	

2.355	

2.573	

1.055

14	

concentrate	

6	

0.175	

0.835	

0.779	

0.732	

0.593	

0.292

Almond Nutmeat	

0.713-0.720	

14	

dilute	

6	

<0.010	

0.024	

0.023	

0.013	

0.015	

0.007

14	

concentrate	

6	

<0.010	

<0.010	

<0.010	

0.005	

0.005	

0.0

Pecan Nutmeat	

0.710-0.725	

14	

dilute	

8	

<0.010	

0.013	

0.011	

0.005	

0.007	

0.003

14	

concentrate	

4	

<0.010	

0.050	

0.047	

0.024	

0.026	

0.024

1. For orchard crops, broadcast foliar applications were made in either
dilute (100-400 GPA) or concentrate (20-100 GPA) spray volumes.

2. For the determination of minimum, maximum, and HAFT values, the LOQ
(0.010 ppm for almond and pecan nutmeat) was used for residues reported
as nondetectable (ND) or at/below the LOQ.  For the determination of the
median, mean, and standard deviation values, half the LOQ (0.005 ppm)
was used for residues reported as ND or below half the LOQ.

Cucurbit Vegetables (Crop Group 9)  Nisso has submitted field trial data
on cucumber, muskmelon, and summer squash, the representative
commodities of the cucurbit vegetables group (Crop Group 9).  A total of
17 cucurbit vegetable field trials were conducted during the 2003
growing season.  Six trials were conducted on cucumber in Regions 2 (SC,
2 trials), 3 (FL, 1 trial), 5 (MI, 2 trials), and 6 (TX, 1 trial); six
trials were conducted on muskmelon in Regions 2 (SC, 1 trial), 5 (MI, 1
trial), 6 (TX, 1 trial), and 10 (CA, 3 trials); and five trials were
conducted on summer squash in Regions 1 (PA, 1 trial), 2 (SC,
1 trial), 3 (FL, 1 trial), 5 (MI, 1 trial), and 10 (CA, 1 trial).  The
number and locations of field trials are in accordance with OPPTS
Residue Chemistry Test Guideline 860.1500 for cucumber, muskmelon, and
summer squash as the representative crops of the cucurbit vegetables
crop group.

At each test location, a total of five foliar broadcast applications of
the Assail( 70WP formulation were made to cucurbit vegetables at a
nominal rate of 0.10 lb ai/A per application, with 4- to 7-day RTIs, for
a nominal total seasonal application rate of 0.50 lb ai/A (the proposed
maximum seasonal rate).  Applications were made using ground equipment;
no adjuvants were added to the spray mixtures.  Samples of mature
cucumber, muskmelon, and summer squash were collected on the day of last
application (0-day PHI).

Samples of cucurbit vegetables were analyzed for residues of
acetamiprid using HPLC/MS/MS method KP-216R0.  The validated LOQ was
0.010 ppm for all cucurbit vegetable matrices.  This method is adequate
for data collection based on acceptable concurrent method recovery data.
 Adequate storage stability data are available to support sample storage
durations and conditions.

The results from the cucurbit vegetable crop field trials are presented
in Table 5.  The maximum residues of acetamiprid were 0.091 ppm in/on
cucumber, 0.142 ppm in/on melon, and 0.221 ppm in/on summer squash
harvested on the day of the last of five foliar broadcast applications
of the Assail( 70WP formulation at the proposed maximum seasonal rate.  

Stone Fruits (Crop Group 12)  Nisso has submitted field trial data on
cherry (sweet and tart), peach, and plum, the representative commodities
of the stone fruits group (Crop Group 12).  A total of 24 stone fruit
field trials were conducted during the 2003 growing season.  Eight
trials were conducted on cherries in Regions 1 (PA, 1 trial), 5 (MI,
2 trials), 9 (CO, 1 trial), 10 (CA, 2 trials), and 11 (OR, 2 trials);
ten trials were conducted on peaches in Regions 1 (PA, 1 trial), 2 (SC,
3 trials), 5 (MI, 1 trial), 6 (TX, 2 trials), and 10 (CA, 3 trials);
and six trials were conducted on plums in Regions 5 (MI, 1 trial), 10
(CA, 4 trials), and 12 (OR, 1 trial).  The number and locations of field
trials are in accordance with OPPTS Residue Chemistry Test Guideline
860.1500 for cherry (sweet and tart), peach, and plum as the
representative crops of the stone fruits crop group.  In addition, the
petitioner adequately addressed geographic representation requirements
in the number of trials conducted using dilute and concentrate spray
volumes.  

At each test location, a total of four broadcast foliar applications of
the Assail( 70WP formulation were made to stone fruits (cherry, peach,
and plum) at a nominal rate of 0.15 lb ai/A per application with a 10-
to 14-day RTIs, for a nominal total seasonal rate of 0.59 lb ai/A (the
proposed maximum seasonal rate).  Applications were made using ground
equipment in either dilute spray volumes (100 to 400 GPA at 4 cherry
trials, 5 peach trials, and 2 plum trials) or concentrate spray volumes
(20 to 100 GPA at 2 trials each for cherry, peach, and plum).  No
adjuvants were added to the spray mixtures.  In addition, at 7 field
trial sites (2 cherry, 3 peach, and 2 plum), applications using dilute
and concentrate spray volumes were made to side-by-side plots.  Samples
of mature cherries (sweet and tart), peaches, and plums were collected
7-8 days following the last application.

Samples of stone fruits (cherry, peach, and plum) were analyzed for
residues of acetamiprid using HPLC/MS/MS method KP-216R1.  The validated
LOQ was 0.010 ppm.  This method is adequate for data collection based on
acceptable concurrent method recovery data.  Adequate storage stability
data are available to support sample storage durations and conditions.

The results from the stone fruit crop field trials are presented in
Table 5.  The maximum residues of acetamiprid were 0.932 ppm in/on
cherries, 0.387 ppm in/on peaches, and 0.116 ppm in/on plums harvested 7
to 8 days following the last of four foliar broadcast applications of
the Assail( 70WP formulation made in dilute spray volumes (100 to 400
GPA) at the proposed maximum seasonal rate.  Maximum residues were
0.767 ppm in/on cherries, 0.565 ppm in/on peaches, and 0.119 ppm in/on
plums harvested 7 days following the last of four foliar broadcast
applications of the Assail( 70WP formulation made in concentrate spray
volumes (20 to 100 GPA) at the proposed maximum seasonal rate.

Tree Nuts (Crop Group 14)  Nisso has submitted field trial data on
almond and pecan, the representative commodities of the tree nuts group
(Crop Group 14).  A total of 12 tree nut field trials were conducted
during the 2003 growing season.  Six trials were conducted on almonds in
Region 10 (CA) and six trials were conducted on pecans in Regions 2 (GA,
3 trials), 4 (AR, 1 trial), 6 (TX, 1 trial), and 8 (AZ, 1 trial). 
The number and locations of field trials are in accordance with OPPTS
Residue Chemistry Test Guideline 860.1500 for almond and pecan as the
representative crops of the tree nuts crop group.  The petitioner
adequately addressed geographic representation requirements in the
number of trials conducted using dilute and concentrate spray volumes
for almonds but not for pecans. 

At each test location, a total of four foliar broadcast applications of
the Assail( 70WP formulation were made to almond and pecan at a nominal
rate of 0.18 lb ai/A per application, at RTIs of approximately 14 days,
for a nominal total seasonal application rate of 0.72 lb ai/A (the
proposed maximum seasonal rate).  Applications were made using ground
equipment in either dilute spray volumes (100 to 400 GPA) or concentrate
spray volumes (20 to 100 GPA).  No adjuvants were added to the spray
mixtures.  Samples of mature almonds and pecans were collected 14 days
following the last application.

Samples of almond nutmeat and hulls and pecan nutmeat were analyzed for
residues of acetamiprid using HPLC/MS/MS method KP-216R1.  The LOQ was
0.010 ppm for almond and pecan nutmeat and 0.020 ppm for almond hulls. 
This method is adequate for data collection based on acceptable
concurrent method recovery data.  Adequate storage stability data are
available to support sample storage durations and conditions.

The results from the tree nut crop field trials are presented in Table
5.  The maximum residues of acetamiprid were 0.024 ppm in/on almond
nutmeat, 4.03 ppm in/on almond hulls, and 0.013 ppm in/on pecan nutmeat
harvested 14 days following the last of four foliar broadcast
applications of the Assail( 70WP formulation made in dilute spray
volumes (100 to 400 GPA) at the proposed maximum seasonal rate.  Maximum
residues were less than 0.010 ppm in/on almond nutmeat, 0.835 ppm in/on
almond hulls, and 0.050 ppm in/on pecan nutmeat harvested 14 days
following the last of four foliar broadcast applications of the Assail(
70WP formulation made in concentrate spray volumes (20 to 100 GPA) at
the proposed maximum seasonal rate.

Conclusions  The submitted crop field trial residue data are adequate to
satisfy data requirements for the proposed uses on the cucurbit
vegetables crop group, the stone fruits crop group, and the tree nuts
crop group.  Although the petitioner did not satisfy geographic
representation requirements for both dilute and concentrate spray
volumes for pecan field trials, HED will not consider that to be a
deficiency for this petition because the test substance is not applied
directly to the RAC of pecans (nutmeat), and residue levels were low in
pecan nutmeats from both types of application.

The maximum residues in plums and cherries differ by significantly more
than 5X, so HED has determined that a crop group tolerance is
inappropriate for the entire stone fruits group.  A group tolerance can
be established for the stone fruits group, except prune plum, with a
separate tolerance for prune plum.  In addition, although the submitted
almond and pecan field trial data may be used to support use on
pistachios, a separate tolerance must be established for pistachios.

No residue decline studies were included in the submitted crop field
trials.  Residue decline studies on cotton, head lettuce, oranges,
pears, and peppers were submitted in conjunction with the original
petition (PP#0F6082, DP Barcode D264154, 12/31/01, M. Doherty).  These
studies indicated that residues of acetamiprid did not increase in the
subject crops with increasing harvest intervals.  Therefore, residue
decline data will not be required to support the cucurbit vegetable,
stone fruit, or tree nut crop field trials.

The submitted data support the following tolerances for residues of
acetamiprid per se:  almond hulls at 5.0 ppm; cucurbit vegetable, group
9, at 0.50 ppm; pistachio at 0.10 ppm; stone fruits, group 12 (except
prune plum) at 1.20 ppm; fresh prune plume at 0.20 ppm; and tree nuts,
group 14, at 0.10 ppm.  

860.1520 Processed Food and Feed

DERs: Stone Fruits, MRID 46265702

Nisso has submitted a processing study for plum.  Two trials were
conducted in CA, one reflecting application in dilute spray volumes, and
one reflecting application in concentrate spray volumes.  At each trial
site, two treatment plots were established.  At one plot, plums were
harvested 7 days following the last of four foliar broadcast
applications of the Assail( 70WP formulation at approximately 0.150 lb
ai/A per application, with 10- to 12-day RTIs, for a nominal total
seasonal application rate of 0.60 lb ai/A (the proposed maximum seasonal
rate).  At the second plot, plums were harvested 7 days following the
last of four foliar broadcast applications of the Assail( 70WP
formulation at approximately 0.60 lb ai/A per application, with 10- to
12-day RTIs, for a nominal total seasonal application rate of 2.4 lb
ai/A (4X the proposed maximum seasonal rate).  Fresh plums from each
trial site were collected at normal maturity, de-pitted, and dried in a
greenhouse for 7 days to produce dried prunes, the processed commodity
of plums. 

Residues of acetamiprid in/on plums and its processed commodity dried
prunes were quantitated using HPLC/MS/MS method KP-216R1.  The validated
LOQ was 0.010 ppm.  This method is adequate for data collection based on
acceptable concurrent method recovery data.  Adequate storage stability
data are available to support sample storage durations and conditions.

The petitioner analyzed samples of plums and dried prunes from the 1X
application rate and samples of dried prunes from the 4X application
rate, but samples of plum RAC from the 4X rate field trials were not
analyzed.  Therefore, processing factors for dried prunes from the
exaggerated rate study could not be determined.  

Residues of acetamiprid were 0.0401 to 0.0624 ppm in/on plums treated at
1X.  The processing data indicate that the residues of acetamiprid may
concentrate in dried prunes (2.9X average processing factor) processed
from plums bearing quantifiable residues.  The processing factors did
not differ significantly between plums receiving applications in dilute
spray volumes and plums receiving applications in concentrate spray
volumes.  

Conclusions  The submitted processing data for plum are adequate to
satisfy data requirements.  The reported processing factor for prunes
does not exceed the theoretical concentration factor of 3.4x for prune
(Table 2 of OPPTS Residue Chemistry Test Guideline 860.1520, based on
loss of water).  Because processing factors could be calculated from the
samples from the 1X rate trials, the lack of residue data for plum RAC
samples from the exaggerated rate study will not be considered a
deficiency for the submitted plum processing study.  

The processing data indicate that the residues of acetamiprid may
concentrate in dried prunes (2.9X average processing factor).  Based on
the average processing factor of 2.9X and a HAFT residue of 0.112 ppm
for plum, the expected residue in dried prune following treatment at 1X
would be 0.33 ppm.  Because the expected residues exceed the recommended
tolerance of 0.20 ppm for fresh prune plum, a recommended separate
tolerance for dried prune plum of 0.40 ppm is required.

860.1650 Submittal of Analytical Reference Standards

As of 7/24/04, analytical reference standards are available for
acetamiprid and three metabolites at the EPA National Pesticide
Standards Repository.

860.1850 Confined Accumulation in Rotational Crops

Cucurbit vegetables are the only annual crop included in the subject
petition, with a proposed maximum seasonal rate of 0.5 lb ai/A.  No new
confined rotational crop data were submitted with this petition.

A confined rotational crop study was reviewed in conjunction with
PP#0F6082 (D264154, 12/31/01, M. Doherty).  In that study,
[pyridine-2,6-14C]acetamiprid was applied to sandy loam soil at 0.66 lb
ai/A (1.3X the proposed maximum seasonal rate to cucurbits), and leafy
vegetable (mustard or lettuce), root (radish), and grain (sorghum or
wheat) crops were planted at 30, 58, 120, and 365 days after treatment. 
14C-Residues accumulated at >0.010 ppm in the commodities of  leafy
vegetable (mustard), root (radish), and grain (sorghum) crops at
plantback intervals of 30 and 58 days.  At the 120-DAT plantback
interval, TRR were >0.010 ppm in mustard greens, radish root and tops,
and wheat forage and straw; residues in wheat grain were <0.010 ppm.  At
the 365-day plantback interval, TRR were >0.010 ppm in lettuce, radish
tops, and sorghum forage and fodder.  In general, residues in rotational
crops decreased with increasing plantback interval.  

Acetamiprid was not detected in any rotational crop matrix at any
plantback interval.  The major metabolite identified in rotational crops
was IM-1-4, at 2.94-56.65% TRR (<0.001-0.040 ppm).  IM-1-4 was
identified in the following crops at >10% TRR:  30-, 58- and 120-DAT
mustard; 30-, 58-, 120-, and 365-DAT radish tops; 30- and 120-DAT radish
root; 30-, 58-, 120-, and 365-DAT grain crop forage and fodder/straw;
and 58-DAT sorghum grain.  Two other metabolites were identified in most
rotational crops:  IM-0-Glc, at 1.11-15.23% TRR (<0.001-0.010 ppm) and
IC-0, at 2.75-24.19% TRR (<0.001-0.014 ppm).  Metabolite IM-0 was
identified in 30-DAT sorghum forage and 58-DAT sorghum fodder at <10%
TRR; this metabolite was not identified in any other rotational crop
matrix.

The confined crop rotational crop study was classified as unacceptable
to satisfy the guideline requirements because insufficient supporting
storage stability data were submitted to support the storage durations
of the rotational crop samples prior to analysis.  Additional data were
required demonstrating the stability of the metabolite profile in
various rotational crop commodities (including radish root and
sorghum/wheat grain, as well as a leafy vegetable) for up to 11 months,
the maximum storage duration for these commodities.  It was concluded
that the storage stability data gap was not sufficient to warrant
rejection of the original petition; however, HED believed that
fulfillment of this data gap should be made a condition of registration.
 The outstanding rotational crop supporting storage stability data have
not yet been submitted.

Based on the available rotational crop data, the MARC determined that
the residue of concern in rotational crops is parent only and that
tolerances would not be needed in rotational crops.  The available
rotational crop data are adequate to support the uses proposed in this
petition.  However, submission of the outstanding rotational crop
supporting storage stability data, which were required as a condition of
registration in the original petition, should be a condition of the
registration requested in this review.



860.1900 Field Accumulation in Rotational Crops

No field rotational crop data have been submitted and no rotational crop
restrictions have been proposed.  The available confined rotational crop
data indicate that no field rotational crop studies are required to
support the proposed uses; no rotational crop restrictions or tolerances
are needed.

860.1550 Proposed Tolerances

The MARC has determined that the nature of the residue in plants and
animals is adequately understood and that the tolerance expression
should include acetamiprid per se for plant commodities and combined
residues of acetamiprid and IM-2-1
[N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-acetamidine] for livestock
commodities.  

There are currently no established Codex or Canadian MRLs for
acetamiprid.  One Mexican MRL is established for acetamiprid on cotton
seed at 0.01 mg/kg.  An International Residue Limit Status sheet is
attached to this review.

The available crop field trial data support tolerances for residues of
acetamiprid per se in/on almond hulls, pistachios, the cucurbit
vegetables group, the stone fruits group, fresh and dried prune plums,
and the tree nuts group.  The available stone fruits group crop field
trial and processed food/feed data indicate that separate tolerances for
fresh plum and dried prune are needed.  Also, the petitioner has
proposed use on pistachio as part of the proposed uses on tree nuts. 
HED has approved modification of the crop group definition for tree nuts
to add pistachio (see memo of 6/14/02 from B. Schneider to H. Jamerson);
however, 40 CFR §180.41 has not yet been revised to include this
modification.  HED has concluded that until 40 CFR is modified, residue
data for almonds and pecans are sufficient to support uses on tree nuts
including pistachios; however, a separate tolerance for pistachio must
be proposed at the same level as the tree nuts group tolerance.  

The proposed tolerances should be revised to reflect the tolerances as
recommended by HED and the correct commodity definitions as specified in
Table 6, below.  



Table 6.	Tolerance Summary for Acetamiprid.

Commodity	

Proposed Tolerance (ppm)	

Recommended Tolerance (ppm)	

Comments

Correct Commodity Definition

Almond hulls	

5.0	

5.0	

Almond, hulls

Stone fruit group, except prune plum	

1.2	

1.20	

Fruit, stone, group 12 (except plum, prune)

Fresh prune plum	

0.30	

0.20	

Proposed tolerance was too high.

Plum, prune, fresh

Dried prune plum	

0.30	

0.40	

Proposed tolerance was too low.

Plum, prune, dried

Tree nut group	

0.10	

0.10	

Nut, tree, group 14

Pistachio	

None proposed	

0.10	

Although tree nut field trial data may be used to support use on
pistachio, a separate tolerance is needed for pistachio.

Pistachio

Cucurbit vegetable group	

0.50	

0.50	

Vegetable, cucurbit, group 9

Attachments:  International Residue Limit Status sheet.



INTERNATIONAL RESIDUE LIMIT STATUS

Chemical Name:
N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine	

Common Name:

Acetamiprid	

X Proposed tolerance

( Reevaluated tolerance

( Other	

Date:  07/28/04

Codex Status (Maximum Residue Limits)	

U. S. Tolerances

X No Codex proposal step 6 or above

( No Codex proposal step 6 or above for the crops requested	

Petition Number:  PP#4F6833

DP Barcode:  303623

Other Identifier:  

Residue definition (step 8/CXL): N/A	

Reviewer/Branch: William T. Drew, RAB2

	

Residue definition:  Acetamiprid

Crop(s)	

MRL (mg/kg)	

Crops 	

Tolerance (ppm)

	

	

Almond, hulls	

5.0

	

	

Fruit, stone, group 12 (except plum, prune)	

1.20

	

	

Plum, prune, fresh	

0.20

	

	

Plum, prune, dried	

0.40

	

	

Nut, tree, group 14	

0.10

	

	

Pistachio	

0.10

	

	

Vegetable, cucurbit, group 9	

0.50

Limits for Canada	

Limits for Mexico

X No Limits

( No Limits for the crops requested	

( No Limits

( No Limits for the crops requested

Residue definition:  N/A

	

Residue definition:  Acetamiprid

Crop(s)	

MRL (mg/kg)	

Crop	

MRL (mg/kg)

	

	

Cotton Seed	

0.01

	

	

	

	

	

	

	

	

	

	

	

	

Notes/Special Instructions: Stephen Funk, 07/28/04.

Acetamiprid	Summary of Analytical Chemistry and Residue Data	DP Barcode:
303623

 PAGE  21