Document ID: EPA-HQ-OPP-2006-0297-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2007-09-19T04:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF              

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES 

MEMORANDUM

DATE:  	04 January 2007

SUBJECT:	Desmedipham.  Acute and Chronic Aggregate Dietary Exposure
Assessment for the Tolerance Reassessment Eligibility Decision on Sugar
Beets and Garden Beets and Risk Assessment for New Uses on Spinach.

PC Code:104801	Chemical Class: Phenyls-carbamate

MRIDs:   46773001, 42516500       	CFR:180.353

                 46734101, 46734102

	

		

From: 		P. Yvonne Barnes, Chemist

Reregistration Branch II 

Health Effects Division (7509P)

THROUGH:			 

		Sheila Piper, Chemist

		Donald Wilbur, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P)

	and

		Alan Nielsen, Branch Senior Scientist

       		Reregistration Branch 2

Health Effects Division (7509P)

TO:		Rich Griffin, Risk Assessor

Reregistration Branch II

Health Effects Division (7509P)

Executive Summary

An acute and chronic aggregate dietary (food and drinking water) risk
assessment were conducted using the Dietary Exposure Evaluation Model
(DEEM-FCID(, Version 2.03), which uses food consumption data from the
USDA’s Continuing Surveys of Food Intakes by Individuals (CSFII) from
1994-1996 and 1998. This analysis is in response to the IR-4 Petition
(PP#6E7027) for tolerance reassessment on Sugar Beet and Garden Beet.
Tolerances are established for residues of desmedipham in/on sugar beet
tops and roots at 0.2 ppm [40 CFR §180.353(a)], and time-limited
tolerances are established at 0.2 ppm in/on red beet roots and at 15 ppm
in/on red beet tops [40 CFR §180.353(b)].  The time-limited tolerances
are set to expire on 06/30/08.  IR-4 has submitted a petition for new
uses on spinach and residue data supporting the use of the 1.3 lb/gal EC
formulation of desmedipham on spinach.

  

Acute Dietary (Food and Drinking Water) Exposure Results and
Characterization

Acute dietary exposure analyses were performed in order to determine the
highlighted exposure and risk estimates which result from the registered
uses of desmedipham.  Tolerance level, field trial data and 100% crop
treated (CT) were used in these assessments.  

A Tier 1 Drinking Water Assessment (DWA) for desmedipham focusing on the
use of sugar beets, derived from surface water sources were used for
this dietary assessment (130 ppb for acute peak and annual average of 71
ppb).

Dietary risk estimates are provided for the U.S. population and all
population subgroups. This assessment concludes that for all supported
registered commodities; the acute dietary risk estimates are below the
Agency’s level of concern (less than 100% of the aPAD) for the U.S.
population and all population subgroups.  Combined dietary exposure from
food and drinking water at the 95th percentile is 8% of the aPAD for the
U.S. population and 26% of the aPAD for all Infants, the most highly
exposed population.  

Chronic Dietary (Food and Drinking Water) Exposure Results and
Characterization

A Tier I dietary exposure assessment was performed for desmedipham i.e.
tolerance level residues and 100% crop treated were assessed.  Dietary
risk estimates are provided for the general U.S. population and various
population subgroups.  This assessment concludes that for all supported
commodities for proposed uses; the chronic dietary risk estimates do not
exceed HED’s level of concern (less than 100% of the cPAD) and all
population subgroups.   Combined dietary exposure from food and drinking
water is 4% of the cPAD for the U.S. population and 13% of the cPAD for
all Infants (<1 year) the most highly exposed population subgroup

Cancer Dietary Exposure Results and Characterization

Desmedipham has no carcinogenic potential.  It has, “tentatively”,
been classified as a “Group E”, “not likely to be carcinogenic to
humans” pending the receipt of historical control data and addressing
other issues with respect to the number of animals examined in the rat
study.  Therefore, no dietary assessment has been performed at this
time.

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  References which
discuss the acute and chronic dietary risk assessments in more detail
are available on the EPA pesticides web site: “Available Information
on Assessing Exposure from Pesticides, A User’s Guide,” 06/21/2000,
web link:    HYPERLINK
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see
SOP 99.6 (08/20/1999).

The most recent dietary exposure analysis for desmedipham was conducted
in 2004, DP Barcode D301554, Sherrie L. Kinard.

 

 II.	Residue Information

The Agency has concluded that the registrant's submitted metabolism
studies for phenmedipham are adequate for desmedipham.  In an HED
Metabolism Committee meeting held on 3/27/95, the Committee has
concluded that the desmedipham residue to be regulated in plants and
animals is desmedipham per se and that (the phenmedipham residue to be
regulated in plants and animals is phenmedipham per se) (D. Miller, CBRS
No. 15293, 04/11/95).    Because desmedipham residues in milk and all
tissues in the metabolism study were < 0.01 ppm, the Agency considers
use of desmedipham on sugar beets to be a 180.6(a)(3) situation for
ruminants (i.e., there is no reasonable expectation of finite residues
in ruminant commodities). 

Desmedipham/Phenmedipham.  Metabolism Committee Decision in reference to
the Regulation of Metabolites; DP Barcode D301553 (06/22/04); CBRS
Number: 15293; No Master Record ID Number, and No Reregistration Case
Number.

Desmedipham Use:  Desmedipham (ethyl-m-hydroxycarbanilate carbanilate)
is a selective herbicide that is currently registered by Aventis
CropSciences (formerly AgrEvo USA Company) for postemergence use on
sugar beets.  Desmedipham is formulated as emulsifiable concentrate (EC)
or wettable powder (WP) formulations.  Time-limited tolerances for
garden beet roots and tops have been established in conjunction with a
Section 18 Emergency Exemption.  Tolerances are listed under 40 CFR
§180.353.

  

Residue Data used for Acute and Chronic Dietary Assessment:

The reassessed tolerance level, field trial data (RDFs) and 100% crop
treated (CT) were used in these assessments (see Table 1 below) 

Table 1

  Data and Residue Estimates Used in Acute and Chronic Dietary Analyses

Commodity	

Field Trial Data

IR-4 (PP#6E7027)	

%

Crop

Treated	

Processing

Factors	Tolerance established under 40 CFR §180.353

(ppm)	Tolerance Reassessment (ppm)

Beet, Garden, root	TOTALZ=0

TOTALNZ=12

12, 0.05	

100	

--	0.2*	0.05

Beet, Garden, tops	TOTALZ=0

TOTALNZ=10

0.058, 0.048, 0.05, 0.05, 0.866, 0.683, 0.084, 0.115, 0.05, 0.05	100	--
15*	1.0

Beet, Sugar, 

roots	TOTALZ=0

TOTALNZ=18

18, 0.05	100	--	0.2	0.1

Beet, Sugar,

tops	TOTALZ=0

TOTALNZ=18

13, 0.05

0.055, 0.103, 0.066, 0.135, 0.119	100	--	0.2	5.0

Spinach	TOTALZ=0

TOTALNZ=15

0.05, 0.05, 0.05, 0.67, 0.38, 5.0, 3.9, 1.8, 2.3, 0.096, 0.18, 0.53,
0.50, 0.69, 0.057	

100	

--	None	6.0

*The time-limited tolerances are set to expire on 06/30/08.

Water Residue Data

The water residue values used in the dietary risk assessment were
provided by the Environmental Fate and Effects Division (EFED) in the
following memo: Drinking Water Exposure Assessment for Use of
Desmedipham on Spinach and Garden Beets (IR-4 Petitions 00337 and 01922)
DP Barcode: D327446, William P. Eckel.

A Tier 1 Drinking Water Assessment (DWA) for desmedipham was completed
on April 20, 2004 for the tolerance reassessment (D294858, D283345). 
That assessment focused on the use on sugarbeets, which comprises almost
99.9% of national use of desmedipham, according to the US Geological
Survey (  HYPERLINK
"http://ca.water.usgs.gov/pnsp/pesticide_use_maps/show_map.php?year=97&m
ap=m9014" 
http://ca.water.usgs.gov/pnsp/pesticide_use_maps/show_map.php?year=97&ma
p=m9014 , accessed 09/01/06).  The balance of the use was on unspecified
beets, presumably under Section 18 registrations for garden beets.

The application rates proposed in the IR-4 petitions are 6 pints (0.975
lb/acre) for a single application on spinach and a total of 6.8 pints
(1.1 lb/acre) divided into 3 applications for beets.  Aerial application
is allowed for spinach, whereas ground spray or banded application is
allowed for beets.  The 2004 DWA assumed aerial application and up to a
1.95 lb/acre total application rate.  Water residues were incorporated
in the DEEM-FCID(, Version 2.03 into the food categories “water,
direct, all sources” and “water, indirect, all sources”. The data
for the annual average surface water concentration for Parent was
converted to parts per million (ppm) before they were entered in
DEEM-FCID(.  Ground water was not included in this assessment, as the
estimated environmental concentration for this water source is minimal
in comparison to surface water.  The results are summarized in Table 2.

Table 2

Tier I Estimated Drinking Water Concentrations

Chemical Name	

Acute (peak) Surface Water Concentration (ppb)	

Annual Average Surface Water Concentration

(ppb)	

Ground Water Concentration 

(ppb)

Desmedipham	

130	

71	

0.039

III.	DEEM-FCID( Program and Consumption Information

Desmedipham acute and chronic dietary exposure assessments were
conducted using the Dietary Exposure Evaluation Model software with the
Food Commodity Intake Database (DEEM-FCID(, Version 2.03), which
incorporates consumption data from USDA’s Continuing Surveys of Food
Intakes by Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98
data are based on the reported consumption of more than 20,000
individuals over two non-consecutive survey days.  Foods “as
consumed” (e.g., apple pie) are linked to EPA-defined food commodities
(e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicly available recipe
translation files developed jointly by USDA/ARS and EPA.  For chronic
exposure assessment, consumption data are averaged for the entire U.S.
population and within population subgroups, but for acute exposure
assessment are retained as individual consumption events.  Based on
analysis of the 1994-96, 98 CSFII consumption data, which took into
account dietary patterns and survey respondents, HED concluded that it
is most appropriate to report risk for the following population
subgroups: the general U.S. population, all infants (less than 1 year
old), children 1-2, children 3-5, children 6-12, youth 13-19, adults
20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

For acute exposure assessments, individual one-day food consumption
data are used on an individual-by-individual basis.  The reported
consumption amounts of each food item can be multiplied by a residue
point estimate and summed to obtain a total daily pesticide exposure for
a deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e. only those who reported
eating relevant commodities/food forms) and a per-capita (i.e., those
who reported eating the relevant commodities as well as those who did
not) basis.  In accordance with HED policy, per capita exposure and risk
are reported for all tiers of analysis.  However, for tiers 1 and 2, any
significant differences in user vs. per capita exposure and risk are
specifically identified and noted in the risk assessment.

IV.	Toxicological Information

In a meeting on October 27, 1998, the Health Effects Division (HED)
Hazard Identification Assessment Review Committee (HIARC) revaluated the
toxicology database for desmedipham, selected doses and endpoints for
acute and chronic dietary exposure risk assessments, and evaluated the
potential enhanced sensitivity of developing fetuses and infant/children
pursuant to the Food Quality Protection Act of 1996 (TXR NO 012991). 
The acute and chronic dietary reference doses and PADs are presented in
Table 3 below. The potential for increased susceptibility of infants and
children from exposure to thifensulfuron methyl was also evaluated as
required by the Food Quality Protection Act (FQPA) of 1996 and HIARC
concluded that no special FQPA safety factor (i.e. 1x) is required since
there are no residual uncertainties for pre and postnatal toxicity.

Desmedipham has no carcinogenic potential.  It has, “tentatively”,
been classified as a “Group E”, “not likely to be carcinogenic to
humans” pending the receipt of historical control data and addressing
other issues with respect to the number of animals examined in the rat
study.  Therefore, no dietary assessment has been performed at this
time.

Table 3 

Summary of Toxicological Doses and Endpoints for Desmedipham

for Use in Dietary Exposure Assessment

Exposure Scenario	

Dose (mg/kg/day)	

Endpoint	

Study

Acute Dietary	

Maternal 

NOAEL = 10

UF = 100

FQPA SF=1X	

Increased maternal methemoglobin	

Developmental Toxicity Study in Rats

MRID 00156725

Acute RfD = 0.10 mg/kg, Acute PAD = 0.10 mg/kg

Chronic Dietary	

NOAEL = 4

UF = 100

FQPA SF=1X	

Anemia and increased spleen weight	

2-Generation Reproduction in Rats

MRID 40387105

Chronic RfD = 0.04 mg/kg, Chronic PAD = 0.04 mg/kg

Results/Discussion

As stated above, for the acute and chronic assessment, HED is concerned
when the dietary risk exceeds 100% of the PAD.  The DEEM-FCID( analysis
estimates the dietary exposure of the U.S. population and various
population subgroups.  The chronic dietary exposure analysis results are
reported in Table 5 for the general U.S. population, all infants (less
than 1 year old), children 1-2, children 3-5, children 6-12, youth
13-19, females 13-49, adults 20-49, and adults 50+ years.  

Dietary risk estimates are provided for the U.S. population and all
population subgroups. This assessment concludes that for all supported
registered commodities; the acute dietary risk estimates are below the
Agency’s level of concern (less than 100% of the aPAD) for the U.S.
population and all population subgroups.  Combined dietary exposure from
food and drinking water at the 95th percentile is 8% of the aPAD for the
U.S. population and 26% of the aPAD for all Infants, the most highly
exposed population. See Table 4 below.

Table 4

Acute Aggregate Dietary Exposure at 95th  Percentile and Risk Estimates
for the Reassessed Tolerances and 100% Crop Treated residue data files
on Sugar Beet, Garden Beet and the proposed New Use on Spinach

	

aPAD ( 0.10 mg/kg bw/day)

	

DEEM-FCID

Population Subgroup	Residue Data Files1	Reassessed Tolerances2

	Exposure 

mg/kg bw/day	% aPAD	Exposure 

mg/kg bw/day	% aPAD

U.S. Population	0.006927

	6.9

	0.007640

	7.6

All infants 	0.025496	25.5	0.025626	25.6

Children 1-2 yrs	0.010859	10.9	0.011649	11.7

Children 3-5 yrs	0.009842	 9.8	0.010406	10.4

Children 6-12 yrs	0.006821	 6.8	0.007231	 7.2

Youth 13-19 yrs	0.005575	 5.6	0.005902	 5.9

Adults 20-49 yrs	0.006396	 6.4	0.007016	 7.0

Adults 50+ yrs	0.005815	 5.8	0.006309	 6.3

Females 13-49 yrs	0.006424	 6.4	0.006424	 6.4

**The values for the highest exposed population are bolded.

1. Anticipated residues were derived from field trial data and RDFs were
created.  See Table 1.

2. Reassessed Tolerances only.

This assessment concludes that for all supported commodities for
proposed uses; the chronic dietary risk estimates do not exceed HED’s
level of concern (less than 100% of the cPAD) and all population
subgroups.   Combined dietary exposure from food and drinking water is
4% of the cPAD for the U.S. population and 13% of the cPAD for all
Infants (<1 year) the most highly exposed population subgroup.  See
Table 5 below.



Table 5

Chronic Aggregate Dietary Exposure and Risk Estimates for Reassessed
Tolerances on Sugar Beet, Garden Beet and the Proposed New Use on
Spinach.

Population Subgroup

	

cPAD ( 0.04 mg/kg bw/day)

	

DEEM-FCID

	

Exposure, mg/kg bw/day	

% cPAD

U.S. Population	

0.001710

	

 4.3

All infants (< 1 yr)	

0.005037	

12.6

Children 1-2 yrs	

0.002585	

 6.5

Children 3-5 yrs	

0.002352	

 5.9

Children 6-12 yrs	

0.001592	

 4.0

Youth 13-19 yrs	

0.001168	

 2.9

Adults 20-49 yrs	

0.001610	

 4.0

Adults 50+ yrs	

0.001735	

 4.3

Females 13-49 yrs	

0.001620

	

 4.0

**The values for the highest exposed population are bolded.

 VI.	Conclusions

The Acute and Chronic Aggregate Dietary Exposure and Risk Estimates for
the U.S. population and all subgroups have dietary exposure and risk
estimates less than 100% of the PAD which is below HED’s level of
concern.

VII.		List of Attachments

			Attachment 1.  Acute Results File (Residue Data Files).

			Attachment 2.  Acute Results File (Reassessed Tolerances).

			Attachment 3.  Acute Input File (Residue Data Files).

			Attachment 4.  Chronic Input File.

			Attachment 5.  Chronic Results File.

Attachment 1.  Acute Results File (Residue Data Files).

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for DESMEDIPHAM                        
(1994-98 data)

Residue file: Desmedipham 01 03 2007 acute.R98    Adjustment factor #2
NOT used.

Analysis Date: 01-03-2007/12:58:43    Residue file dated:
01-03-2007/12:53:17/8

Daily totals for food and foodform consumption used.

MC iterations = 1000      MC list in residue file     MC seed = 10

Run Comment: ""

========================================================================
=======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
--------

U.S. Population:

                    0.006927     6.93    0.013120    13.12    0.026355  
 26.36 

All infants:

                    0.025496    25.50    0.036829    36.83    0.065502  
 65.50 

Children 1-2 yrs:

                    0.010859    10.86    0.018758    18.76    0.028253  
 28.25 

Children 3-5 yrs:

                    0.009842     9.84    0.015507    15.51    0.031799  
 31.80 

Children 6-12 yrs:

                    0.006821     6.82    0.011613    11.61    0.016347  
 16.35 

Youth 13-19 yrs:

                    0.005575     5.57    0.009377     9.38    0.016672  
 16.67 

Adults 20-49 yrs:

                    0.006396     6.40    0.010852    10.85    0.019300  
 19.30 

Adults 50+ yrs:

                    0.005815     5.81    0.008644     8.64    0.015599  
 15.60 

Females 13-49 yrs:

                    0.006424     6.42    0.010709    10.71    0.020082  
 20.08 

Attachment 2.  Acute Results File (Reassessed Tolerances).

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for DESMEDIPHAM                        
(1994-98 data)

Residue file: Desmedipham 01 04 2007 acute tol.R98

Adjustment factor #2 NOT used.

Analysis Date: 01-04-2007/14:18:51    Residue file dated:
01-04-2007/14:17:08/8

Daily totals for food and foodform consumption used.

Run Comment: ""

========================================================================
=======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
--------

U.S. Population:

                    0.007640     7.64    0.015808    15.81    0.034876  
 34.88 

All infants:

                    0.025626    25.63    0.037685    37.69    0.073484  
 73.48 

Children 1-2 yrs:

                    0.011649    11.65    0.021319    21.32    0.078957  
 78.96 

Children 3-5 yrs:

                    0.010406    10.41    0.017198    17.20    0.055068  
 55.07 

Children 6-12 yrs:

                    0.007231     7.23    0.012605    12.61    0.023224  
 23.22 

Youth 13-19 yrs:

                    0.005902     5.90    0.010431    10.43    0.022236  
 22.24 

Adults 20-49 yrs:

                    0.007016     7.02    0.013718    13.72    0.029885  
 29.89 

Adults 50+ yrs:

                    0.006309     6.31    0.012853    12.85    0.033900  
 33.90 

Females 13-49 yrs:

                    0.007097     7.10    0.013634    13.63    0.030134  
 30.13 

Attachment 3.  Acute Input File (Residue Data Files).

U.S. Environmental Protection Agency                                
Ver. 2.02

DEEM-FCID Acute analysis for DESMEDIPHAM

Residue file name: F:\USER\PBARNES\Desmedipham\Spinach sugar beets
garden beets\Desmedipham 01 03 2007 acute.R98

Analysis Date 01-03-2007             Residue file dated:
01-03-2007/12:53:17/8

Reference dose (aRfD) = 0.1 mg/kg bw/day

------------------------------------------------------------------------
--------

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1           Param #2    Param #3    Comment

  #   Code 

----- ---- ------------           ----------- ----------- ----------

  1    6   Garden beets root.rdf

  2    6   Garden beets tops.rdf

  3    6   Spinach.rdf

  4    6   Sugar  beets root.rdf

  5    6   Sugar  beets tops.rdf

  EPA    Crop Food Name                         Def Res     Adj.Factors 
RDL  Comment

  Code    Grp                                    (ppm)       #1     #2  
Pntr

-------- ---- -------------------------------  ----------  ------ ------
---  -------

01010500 1AB  Beet, garden, roots                0.050000   1.000  1.000
  1  

02000510 2    Beet, garden, tops                 1.000000   1.000  1.000
  2  

01010521 1A   Beet, sugar-babyfood               0.100000   1.000  1.000
  4  

01010530 1A   Beet, sugar, molasses              5.000000   1.000  1.000
  5  

01010531 1A   Beet, sugar, molasses-babyfood     5.000000   1.000  1.000
  5  

04013550 4A   Spinach                            6.000000   1.000  1.000
  3  

86010000 O    Water, direct, all sources         0.130000   1.000  1.000
     

86020000 O    Water, indirect, all sources       0.130000   1.000  1.000
     

Attachment 4. Chronic Input File.

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for DESMEDIPHAM                       
1994-98 data

Residue file: F:\USER\PBARNES\Desmedipham\Spinach sugar beets garden
beets\Desmedipham 1 03 2007 chronic.R98

                                                           Adjust. #2
NOT used

Analysis Date 01-03-2007             Residue file dated:
01-03-2007/12:42:33/8

Reference dose (RfD) = 0.04 mg/kg bw/day

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

01010500 1AB  Beet, garden, roots                0.050000   1.000     
1.000   

02000510 2    Beet, garden, tops                 1.000000   1.000     
1.000   

01010521 1A   Beet, sugar-babyfood               0.100000   1.000     
1.000   

01010530 1A   Beet, sugar, molasses              5.000000   1.000     
1.000   

01010531 1A   Beet, sugar, molasses-babyfood     5.000000   1.000     
1.000   

04013550 4A   Spinach                            6.000000   1.000     
1.000   

86010000 O    Water, direct, all sources         0.071000   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.071000   1.000     
1.000   

Attachment 5.  Chronic Results File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for DESMEDIPHAM                      (1994-98
data)

Residue file name: F:\USER\PBARNES\Desmedipham\Spinach sugar beets
garden beets\Desmedipham 1 03 2007 chronic.R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 01-03-2007/12:43:45     Residue file dated:
01-03-2007/12:42:33/8

Reference dose (RfD, Chronic) = .04 mg/kg bw/day

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.001710                
4.3%

U.S. Population (spring season)             0.001689                
4.2%

U.S. Population (summer season)             0.001763                
4.4%

U.S. Population (autumn season)             0.001668                
4.2%

U.S. Population (winter season)             0.001723                
4.3%

Northeast region                            0.001650                
4.1%

Midwest region                              0.001657                
4.1%

Southern region                             0.001619                
4.0%

Western region                              0.001968                
4.9%

Hispanics                                   0.001847                
4.6%

Non-hispanic whites                         0.001659                
4.1%

Non-hispanic blacks                         0.001662                
4.2%

Non-hisp/non-white/non-black                0.002371                
5.9%

All infants (< 1 year)                      0.005037               
12.6%

Nursing infants                             0.001983                
5.0%

Non-nursing infants                         0.006196               
15.5%

Children 1-6  yrs                           0.002378                
5.9%

Children 7-12 yrs                           0.001511                
3.8%

Females 13-19 (not preg or nursing)         0.001110                
2.8%

Females 20+ (not preg or nursing)           0.001774                
4.4%

Females 13-50 yrs                           0.001657                
4.1%

Females 13+ (preg/not nursing)              0.001514                
3.8%

Females 13+ (nursing)                       0.002489                
6.2%

Males 13-19 yrs                             0.001216                
3.0%

Males 20+ yrs                               0.001522                
3.8%

Seniors 55+                                 0.001718                
4.3%

Children 1-2 yrs                            0.002585                
6.5%

Children 3-5 yrs                            0.002352                
5.9%

Children 6-12 yrs                           0.001592                
4.0%

Youth 13-19 yrs                             0.001168                
2.9%

Adults 20-49 yrs                            0.001610                
4.0%

Adults 50+ yrs                              0.001735                
4.3%

Females 13-49 yrs                           0.001620                
4.0%

Desmedipham	Dietary Exposure and Risk Assessment	DP Barcode: DP 334732

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Desmedipham	Dietary Exposure and Risk Assessment	DP Barcode: 334732

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Desmedipham	Dietary Exposure and Risk Assessment	DP Barcode: 334732

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