Document ID: EPA-HQ-OPP-2004-0205-0003
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2004-07-09T04:00Z

DRAFT
7/
7/
04
CHEMICAL
HAZARD
CLASSIFICATION
AND
LABELING
:

COMPARISON
OF
OPP
REQUIREMENTS
AND
THE
GHS
CONTENTS
I.
SCOPE
AND
PURPOSE
.
.
.
.
.
.
.
.
.
.
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.
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.
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.
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.
.
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.
.
.
.
2
II.
GENERAL
COMPARISON
OF
OPP
PRACTICE
AND
THE
GHS
.
.
.
.
.
.
.
.
.
.
.
.
.
.
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.
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.
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.
.
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.
.
.
.
.
.
.
.
.
.
.
3
III.
ACUTE
TOXICITY
.
.
.
.
.
.
.
.
.
.
.
.
.
.
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.
.
.
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.
.
.
.
5
IV.
SKIN
CORROSION/
IRRITATION
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
9
V.
SERIOUS
EYE
DAMAGE
/
IRRITATION
.
.
.
.
.
.
.
.
.
.
.
.
.
.
11
VI.
SKIN/
DERMAL
SENSITIZATION
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
13
VII.
ENVIRONMENTAL
HAZARDS
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
15
VIII.
FLAMMABILITY
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
18
IX.
OTHER
PHYSICAL
OR
CHEMICAL
HAZARDS
.
.
.
.
.
.
.
.
22
DRAFT
7/
7/
04
2
I.
SCOPE
AND
PURPOSE
This
document
compares
current
OPP
classification
and
labeling
requirements,
as
presented
in
the
OPP
Label
Review
Manual
and
regulations
(
40
CFR
156),
with
the
provisions
of
the
Globally
Harmonized
System
of
Classification
and
Labelling
of
Chemicals
(
GHS)
as
adopted
by
the
United
Nations
Economic
and
Social
Council
in
July
2003
(
text
at
http://
www.
unece.
org/
trans/
danger/
publi/
ghs/
officialtext.
html).
It
indicates
how
OPP
label
policies
would
need
to
change
to
be
consistent
with
the
GHS.

The
GHS
includes
classification
criteria
and
label
elements
for
some
physical
hazards,
respiratory
sensitization
and
chronic
effects
that
OPP
does
not
now
routinely
label.
Since
implementation
of
the
GHS
does
not
mandate
hazard
labeling
of
these
effects
and
there
are
no
standard
OPP
practices
to
compare
to
GHS
criteria
and
label
elements,
they
are
not
included
in
this
comparison.

OPP
requires
labeling
for
environmental
effects
not
covered
by
the
GHS,
which
includes
only
aquatic
effects.
These,
too,
are
not
included
in
this
document
since
there
are
no
GHS
provisions
to
compare
to
OPP
requirements.
OPP's
current
practices
would
not
need
to
change
to
be
consistent
with
the
GHS,
since
the
GHS
notes
that
authorities
may
impose
labeling
requirements
to
provide
supplemental
information,
including
information
on
hazards
not
covered
by
the
system,
provided
they
do
not
undermine
or
detract
from
GHS
label
information.
(
GHS
1.4.10.5.4.2)

It
is
important
to
note
that
the
GHS
is
aimed
at
harmonizing
classification/
hazard
identification
for
hazard
communication
purposes,
not
risk
assessment,
management
or
mitigation
measures.
(
GHS
1.1.2.6)
A
separate
exercise
is
required
to
determine
if
risk
management
measures
that
are
now
tied
to
hazard
classification
should
be
"
decoupled."
Initial
analyses
during
development
of
the
GHS
indicated
that
there
were
few
OPP
requirements,
beyond
labeling,
that
were
triggered
automatically
by
hazard
classification.
Consistency
with
the
GHS
does
not
require
continued
linkage
of
classification
with
measures
beyond
hazard
communication
in
labeling
and
safety
data
sheets.
DRAFT
7/
7/
04
3
II.
GENERAL
COMPARISON
OF
OPP
PRACTICE
AND
THE
GHS
(
THESE
POINTS
APPLY
ACROSS
HAZARD
CLASSES)

1.
GHS
organizes
the
hazard
characteristics
of
chemicals
based
on
"
hazard
classes"
(
specific
physical,
health
or
environmental
effects,
such
as
flammability,
acute
toxicity,
aquatic
toxicity)
which
are
sub­
divided
into
numerical
"
hazard
categories"
based
on
the
severity
of
the
hazard.
The
use
of
the
term
"
category"
is
thus
essentially
the
same
as
current
OPP
practice.
The
GHS
uses
Arabic
numerals
consistently,
while
OPP
uses
Roman
numerals.

2.
OPP
only
uses
one
symbol,
the
skull
and
crossbones
for
severe
acute
toxicity
and
products
containing
methanol
at
concentrations
above
4%.
The
GHS
uses
symbols
for
all
hazard
classes
(
but
not
all
categories).

3.
GHS
pictograms
are
composed
of
the
appropriate
symbol
surrounded
by
a
red
diamond­
shaped
border,
except
that
authorities
may
allow
a
black
diamond
border
if
the
chemical
is
for
domestic
use
only.
OPP
does
not
prescribe
borders
around
the
symbol.

4.
OPP
uses
three
signal
words
(
danger,
warning,
and
caution);
the
GHS
only
two
(
danger
and
warning).
OPP
prohibits
the
use
of
signal
words
for
environmental
or
physical
hazards;
the
GHS
mandates
their
use
for
some
categories
(
e.
g.,
extremely
flammable
liquids).

5.
GHS
"
hazard
statements"
are
simple
statements
of
hazard,
a
subset
of
what
OPP
calls
"
precautionary
statements."
GHS
does
not
specify
any
precautionary
statements
(
e.
g.,
first
aid,
personal
protective
equipment)
beyond
hazard
statements.
There
are
plans
for
future
work
to
harmonize
additional
precautionary
language
at
the
international
level
through
the
GHS.

6.
The
GHS
calls
for
product
identifiers
on
labels
but
does
not
specify
them.
It
also
calls
for
disclosure
of
ingredients
that
contribute
to
the
hazard
classification
of
a
mixture,
but
provides
that
national
rules
governing
disclosure
of
Confidential
Business
Informaton
will
take
precedence
over
ingredient
disclosure
provisions
(
GHS
1.4.10.5.2(
d).

7.
The
GHS
contains
conservative
bridging
principles
for
classifying
untested
chemical
mixtures
that
are
consistent
with
principles
currently
used
by
OPP.
(
For
example,
for
acute
toxicity,
see
GHS
section
3.1.3.5).

8.
The
GHS
also
contains
formulae
for
estimating
the
toxicity
of
untested
mixtures
based
on
the
toxicities
of
known
ingredients.
It
is
not
expected
that
OPP
will
use
this
approach.
Rather,
OPP
is
expected
to
require
test
data,
consistent
with
current
practice,
unless
there
DRAFT
7/
7/
04
4
is
a
sound
scientific
basis
for
changing
current
practice.
The
rules
for
classifying
untested
mixtures
under
the
GHS
are
designed
to
ensure
that
the
best
available
scientific
information
is
used
for
classification
of
all
types
of
chemicals.

9.
The
GHS
is
testing,
and
test­
method,
neutral
for
health
and
environmental
hazards
and
is
designed
to
permit
self­
classification
to
the
maximum
extent
possible.
U.
S.
law
recognizes
that
pesticides,
which
are
intended
to
be
biologically
active
and
have
effects
on
living
organisms,
should
be
subject
to
testing
and
approved
by
a
regulatory
agency
before
they
may
be
legally
marketed.
This
is
not
the
case
for
some
other
types
of
chemicals.
Some
regulatory
agencies
do
not
have
the
authority
to
require
test
data.
Chemicals
may
be
legally
marketed
without
prior
regulatory
approval
or
label
review,
and
it
is
up
to
producers
to
classify
and
label
them
based
on
the
requirements
of
the
appropriate
regulatory
agencies.
The
GHS
is
designed
to
meet
the
needs
of
both
types
of
systems.

10.
The
GHS
specifies
test
methods
for
physical
hazards.
To
be
consistent
with
the
GHS,
OPP
would
need
to
adopt
both
these
methods
and
the
corresponding
GHS
label
elements.

11.
Except
as
detailed
in
the
specific
hazard
class
comparisons
in
the
following
sections
of
this
paper,
other
existing
OPP
label
information
requirements
appear
consistent
with
the
GHS'
allowance
for
"
supplemental
information,"
so
long
as
that
label
information
does
not
undermine
GHS
label
elements.
(
See
GHS
sections
1.4.6.3
and
1.4.10.5.4.2
.)
For
example,
such
information
may
cover
hazards
not
covered
by
GHS
or
provide
greater
detail.

12.
Both
the
GHS
and
OPP
specify
that
labels
should
include
product
and
supplier
identifiers.
These
elements
of
the
GHS
are
not
"
standardized,"
but
are
generally
consistent
with
OPP
practice.

13.
Since
the
principal
purpose
of
this
document
is
to
indicate
label
changes
that
would
be
necessary
to
conform
to
the
GHS,
classification
criteria
are
presented
in
summary
fashion,
as
they
are
in
the
Label
Review
Manual.
This
document
does
not
attempt
to
include
all
exceptions
or
special
circumstances
that
might
lead
to
divergent
classifications,
which
of
course
could
lead
to
different
label
requirements
and
would
still
be
considered
consistent
with
GHS
implementation.
DRAFT
7/
7/
04
5
III.
OPP/
GHS
CLASSIFICATION
CRITERIA
AND
LABELING
COMPARISON:

ACUTE
TOXICITY
Summary
Comparison:

$
The
GHS
has
five
categories
for
acute
toxicity.
OPP
currently
uses
four
categories.
OPP
Category
IV
has
no
upper
limit.
GHS
Category
5
covers
chemicals
with
toxicities
expected
to
fall
in
the
range
of
oral
and
dermal
LD
50
of
2000
mg/
kg
­
5000
mg/
kg,
or
equivalent
doses
for
inhalation
toxicity.

$
The
basis
of
classification
in
both
systems
is
the
same:
LD/
LC
50
values
or
"
acute
toxicity
estimates"
of
the
LD/
LC
50
.

$
OPP
uses
the
"
danger"
signal
word
and
skull
and
crossbones
symbol
for
chemicals
in
Categories
I
and
II
(
e.
g.,
oral
LD
50
of
up
to
50
mg/
kg).
GHS
uses
the
"
danger"
signal
word
and
skull
and
cross
bones
symbol
for
chemicals
in
Categories
1­
3
(
e.
g.,
oral
LD
50
of
up
to
300
mg/
kg)
and
introduces
the
exclamation
point
symbol
for
Category
4.

$
The
GHS
specifies
different
classification
criteria
for
inhalation
toxicity
based
on
whether
the
chemical
is
(
1)
a
gas,
(
2)
a
vapor,
or
(
3)
a
dust
or
mist.
OPP
does
not
distinguish
among
different
types
of
inhalation
toxicants.
DRAFT
7/
7/
04
6
OPP
Criteria,
Signal
Words,
Symbol,
and
Hazard
Statements
GHS
Criteria,
Signal
Words,
Pictograms
and
Hazard
Statements
ACUTE
ORAL
TOXICITY:

Category
I
LD
50
<
50
mg/
kg
DANGER
Skull
and
Crossbones
Fatal
if
swallowed
Category
II
LD
50
>
50
mg/
kg
<
500
mg/
kg
WARNING
No
symbol
May
be
fatal
if
swallowed
Category
III
LD
50
>
500
mg/
kg
<
5000
mg/
kg
CAUTION
No
symbol
Harmful
if
swallowed
Category
IV
LD
50
>
5000
mg/
kg
CAUTION
or
no
signal
word
No
symbol
No
hazard
statement
required;
registrant
may
choose
to
use
Category
III
statement
ACUTE
ORAL
TOXICITY:

Category
1
LD
50
<
5
mg/
kg
and
Category
2
LD
50
>
5
mg/
kg
<
50
mg/
kg
DANGER
Skull
and
Crossbones
in
diamond
Fatal
if
swallowed
Category
3
LD
50
>
50
mg/
kg
<
300
mg/
kg
DANGER
Skull
and
Crossbones
in
diamond
Toxic
if
swallowed
Category
4
LD
50
>
300
mg/
kg
<
2000
mg/
kg
WARNING
Exclamation
point
in
diamond
Harmful
if
swallowed
Category
5
LD
50>
2000
mg/
kg
<
5000
mg/
kg
(
See
Note
(
e)
to
GHS
Table
3.1.1.)
WARNING
No
symbol
May
be
harmful
if
swallowed
[
LD
50
>
5000
mg/
kg
not
classified;
no
specified
label
elements]
DRAFT
7/
7/
04
7
OPP
Criteria,
Signal
Words,
Symbol,
and
Hazard
Statements
GHS
Criteria,
Signal
Words,
Pictograms
and
Hazard
Statements
ACUTE
DERMAL
TOXICITY
Category
I
LD
50
<
200
mg/
kg
DANGER
Skull
and
Crossbones
Fatal
in
contact
with
skin
Category
II
LD
50
>
200
mg/
kg
<
2000
mg/
kg
WARNING
No
symbol
May
be
fatal
in
contact
with
skin
Category
III
LD
50
>
2000
mg/
kg
<
5000
mg/
kg
CAUTION
No
symbol
Harmful
in
contact
with
skin
Category
IV
LD
50
>
5000
mg/
kg
CAUTION
or
no
signal
word
No
symbol
No
hazard
statement
required;
registrant
may
choose
to
use
Category
III
statement
ACUTE
DERMAL
TOXICITY
Category
1
LD
50
<
50
mg/
kg
and
Category
2
LD
50
>
50
mg/
kg
<
200
mg/
kg
DANGER
Skull
and
Crossbones
in
diamond
Fatal
in
contact
with
skin
Category
3
LD
50
>
200
mg/
kg
<
1000
mg/
kg
DANGER
Skull
and
Crossbones
in
diamond
Toxic
in
contact
with
skin
Category
4
LD
50
>
1000
mg/
kg
<
2000
mg/
kg
WARNING
Exclamation
point
in
diamond
Harmful
in
contact
with
skin
Category
5
LD
50
>
2000
mg/
kg
<
5000
mg/
kg
(
See
Note
(
e)
to
GHS
Table
3.1.1.)
WARNING
No
symbol
May
be
harmful
in
contact
with
skin
[
LD
50
>
5000
mg/
kg
Not
classified;
no
specified
label
elements]
DRAFT
7/
7/
04
8
OPP
Criteria
Signal
Words,
Symbol,
and
Hazard
Statements
GHS
Criteria,
Signal
Words,
Pictograms,
and
Hazard
Statements
ACUTE
INHALATION
TOXICITY
Category
I
LC
50
<
0.05
mg/
L
DANGER
Skull
and
crossbones
Fatal
if
inhaled
Category
II
LC
50
>
0.05
mg/
L
<
0.5
mg/
L
WARNING
No
symbol
May
be
fatal
if
inhaled
Category
III
LC
50
>
0.5
mg/
L
<
2.0
mg/
L
CAUTION
No
Symbol
Harmful
if
inhaled
Category
IV
LC
50>
2
mg/
L
No
label
elements
required.
Registrant
may
choose
to
use
Category
III
labeling.
ACUTE
INHALATION
TOXICITY
Category
1
Dusts
and
mists:
LC
50
<
0.05
mg/
L
Gases:
LC
50
<
100
ppm/
V
Vapors:
LC
50
<
0.5
mg/
L
DANGER
Skull
and
crossbones
in
diamond
Fatal
if
inhaled
Category
2
Dusts
and
mists:
LC
50
>
0.05
mg/
L<
0.5
mg/
L
Gases:
LC
50
>
100
ppm/
V
<
500
ppm/
V
Vapors:
LC
50
>
0.5
mg/
L
<
2.0
mg/
L
DANGER
Skull
and
Crossbones
in
diamond
Fatal
if
inhaled
Category
3
Dusts
and
mists:
LC
50
>
0.5
mg/
L
<
1.0
mg/
L
Gases:
LC
50
>
500
ppm/
V
<
2500
ppm/
V
Vapors:
LC
50
>
2.0
mg/
L
<
10
mg/
L
DANGER
Skull
and
Crossbones
in
diamond
Toxic
if
inhaled
Category
4
Dusts
and
mists:
LC
50
>
1.0
mg/
L<
5
mg/
L
Gases:
LC
50
>
2500
ppm/
V
<
5000
ppm/
V
Vapors:
LC
50
>
10
mg/
L
<
20
mg/
L
WARNING
Exclamation
point
in
diamond
Harmful
if
inhaled
Category
5
Dose
equivalent
to
oral
or
dermal
LC
50
of
2000­
5000mg/
kg,(
See
Note
(
e)
to
GHS
Table
3.1.1.)
WARNING
No
Symbol
Maybe
harmful
if
inhaled
DRAFT
7/
7/
04
9
IV.
OPP/
GHS
CLASSIFICATION
CRITERIA
AND
LABELING
COMPARISON:

SKIN
CORROSION/
IRRITATION
Summary
Comparison:

$
Both
OPP
and
GHS
have
a
single
category
for
skin
corrosion.
The
GHS
subdivides
this
category
based
on
duration
of
exposure,
but
the
label
elements
are
the
same.

$
GHS
assumes
that
skin
corrosives
also
cause
severe
eye
damage
and
includes
eye
damage
in
the
hazard
statement.
OPP
does
not,
although
in
practice
he
statements
are
often
combined
for
these
effects
based
on
data
or
other
information
(
e.
g.,
pH
values).

$
OPP
defines
skin
irritation
qualitatively
(
severe,
moderate,
and
mild/
slight/
no
irritation)
based
on
72
hour
exposures.
The
GHS
classification
criteria
specify
scores
and
exposure
times
from
commonly­
used
test
protocols.
These
are
consistent
with
OPP
practice.

$
OPP
has
three
irritant
categories:
severe,
moderate,
or
mild/
slight/
no
irritation.
GHS
has
two
irritant
categories:
irritant
and
mild
irritant.

$
OPP
requires
no
symbols
for
skin
corrosion/
irritation.
GHS
uses
a
corrosion
symbol
for
Category
1
(
corrosives),
an
exclamation
point
for
Category
2
irritants,
and
no
symbol
for
Category
3
(
mild)
irritants.

$
Both
OPP
and
GHS
use
the
signal
word
"
danger"
for
skin
corrosives.
OPP
requires
the
signal
word
"
warning"
for
severe
irritants
and
"
caution"
for
moderate
irritants.
GHS
specifies
the
signal
word
"
warning"
for
all
chemicals
that
cause
irritation
and
does
not
classify
or
prescribe
label
elements
for
chemicals
that
do
not
meet
the
criteria
for
irritation.
DRAFT
7/
7/
04
10
OPP
Criteria,
Signal
Words,
Sybmol,
and
Hazard
Statements
GHS
Criteria,
Signal
Words,
Pictograms,
and
Hazards
Statements
SKIN
CORROSION
Category
I
Corrosive
(
tissue
destruction
into
the
dermis
and/
or
scarring)
DANGER
No
symbol
Corrosive.
Causes
skin
burns.

SKIN
IRRITATION
Category
II
Severe
irritation
(
severe
erythema
or
edema)
at
72
hours
WARNING
No
symbol
Causes
skin
irritation.

Category
III
Moderate
irritation
(
moderate
erythema)
at
72
hours
CAUTION
No
symbol
No
hazard
statement
(
other
than
precautionary
language
that
specifies
"
avoid
contact
with
skin
or
clothing")

Category
IV
Mild
or
slight
irritation
(
no
irritation
or
slight
erythema)
at
72
hours
No
signal
word,
symbol
or
hazard
statement
required.
Registrant
may
choose
to
use
Category
III
statement
SKIN
CORROSION
Category
1
A,
B,
C
Destruction
of
skin
tissue,
with
sub­
categorization
based
on
exposure
of
up
to
3
minutes
(
A),
1
hour
(
B),
or
4
hours
(
C).
DANGER
Corrosion
symbol
in
diamond.
Causes
severe
skin
burns
and
eye
damage.

SKIN
IRRITATION
Category
2
Mean
value
of

2.3
>
4.0
for
erythema
/
eschar
or
edema
in
at
least
2
of
3
tested
animals
from
gradings
at
24,
48,
and
72
hours
(
or
on
3
consecutive
days
after
onset
if
reactions
are
delayed);
inflammation
that
persists
to
end
of
the
(
normally
14­
day)
observation
period.
WARNING
Exclamation
mark
in
diamond
Causes
skin
irritation.

Category
3
Mean
value
of

1.5
<
2.3
for
erythema
/
eschar
or
edema
in
at
least
2
of
3
tested
animals
from
gradings
at
24,
48,
and
72
hours
(
or
on
3
consecutive
days
after
onset
if
reactions
are
delayed)
WARNING
No
symbol
Causes
mild
skin
irritation.

No
classification
or
labeling
unless
Category
1­
3
criteria
are
met.
DRAFT
7/
7/
04
11
V.
OPP/
GHS
CLASSIFICATION
CRITERIA
AND
LABELING
COMPARISON:

SERIOUS
EYE
DAMAGE
/
IRRITATION
Summary
Comparison:

$
Both
OPP
and
the
GHS
have
one
category
for
corrosion/
serious
eye
damage/
irreversible
effects
on
the
eye
and
use
the
signal
word
"
danger"
for
this
category.
The
GHS
also
specifies
the
corrosion
symbol.
OPP
requires
no
symbol.

$
OPP
uses
three
categories
for
eye
irritants.
GHS
uses
one
category
that
is
further
divided
into
two
subcategories,
"
irritant"
and
"
mild
irritant."
Mild
irritant
effects
are
those
that
are
fully
reversible
within
7
days.

$
OPP
uses
the
"
warning"
signal
word
and
no
symbol
for
irritants
in
Category
II
and
"
caution"
and
no
symbol
for
Category
III.
GHS
uses
"
warning"
and
the
exclamation
mark
symbol
for
Category
2A
irritants
and
"
warning"
but
no
symbol
for
Category
2B
mild
irritants.

$
Both
OPP
and
GHS
classification
criteria
are
based
on
severity
and
duration
of
effects.
OPP
classification
criteria
for
severity
are
described
more
qualitatively
in
the
Label
Review
Manual.
The
GHS
specifies
scores
from
commonly
used
tests;
these
are
consistent
with
OPP
practice.

$
OPP
provides
for
Category
IV
classification
of
pesticides
which
cause
minimal
eye
effects
that
clear
in
less
than
24
hours.
Such
pesticides
are
not
requiring
to
carry
signal
words
or
hazard
statements,
but
registrants
may
choose
to
use
the
Category
III
hazard
statement.
GHS
has
no
similar
"
minimal
effects"
category.
DRAFT
7/
7/
04
12
OPP
Criteria,
Signal
Words,
Symbol,
and
Hazard
Statements
GHS
Criteria,
Signal
Word,
Pictograms,
and
Label
Statements
PRIMARY
EYE
IRRITATION
Category
I
Corrosive
(
irreversible
destruction
of
ocular
tissue)
or
corneal
involvement
or
irritation
persisting
for
more
than
21
days.
DANGER
No
symbol
Corrosive.
Causes
irreversible
eye
damage.

Category
II
Corneal
involvement
or
irritation
clearing
in
8­
21
days.
WARNING
No
symbol
Causes
substantial
but
temporary
eye
injury.

Category
III
Corneal
involvement
or
irritation
clearing
in
7
days
or
less.
CAUTION
No
symbol
Causes
moderate
eye
irritation.

Category
IV
Minimal
effects
clearning
in
less
than
24
hours.
No
signal
word,
symbol
or
hazard
statement
required.
Registrant
may
choose
to
use
Category
III
statement.
SERIOUS
EYE
DAMAGE/
EYE
IRRITATION
Category
1
Effects
on
the
cornea,
iris
or
conjunctiva
that
are
not
expected
to
reverse
or
that
have
not
fully
reversed
within
21
days.
DANGER
Corrosion
symbol
in
diamond.
Causes
severe
eye
damage.

Category
2A
Effects
on
the
cornea,
iris
or
conjunctiva
that
fully
reverse
within
21
days.
WARNING
Exclamation
mark
in
diamond.
Causes
severe
eye
irritation.

Category
2B
Effects
on
the
cornea,
iris
or
conjunctiva
that
fully
reverse
within
7
days.
WARNING
No
symbol
Causes
eye
irritation.
DRAFT
7/
7/
04
13
VI.
OPP/
GHS
CLASSIFICATION
CRITERIA
AND
LABELING
COMPARISON:

SKIN/
DERMAL
SENSITIZATION
Summary
Comparison
:

$
Both
OPP
and
the
GHS
essentially
use
one
category,
though
OPP
does
not
use
the
term
"
category"
for
this
effect.
A
chemical
is
either
classified
as
a
skin
sensitizer
or
it
is
not.

$
The
GHS
uses
the
signal
word
"
warning"
and
the
exclamation
mark
symbol
for
skin
sensitizers.
OPP
uses
no
symbol
and
no
signal
word.
DRAFT
7/
7/
04
14
OPP
Criteria,
Signal
Words,
Symbol,
and
Hazard
Statements
GHS
Criteria,
Signal
Word,
Pictograms,
and
Label
Statements
SKIN/
DERMAL
SENSITIZATION
Product
is
a
sensitizer
or
is
positive
for
sensitization.

No
signal
word
No
symbol
Prolonged
or
frequently
repeated
skin
contact
may
cause
allergic
reactions
in
some
individuals.
SKIN/
DERMAL
SENSITIZATION
Category
1
Evidence
in
humans
that
the
substance
can
induce
sensitization
by
skin
contact
in
a
substantial
number
of
persons,
or
positive
results
from
appropriate
animal
tests.

WARNING
Exclamation
mark
in
diamond
May
cause
allergic
skin
reaction.
DRAFT
7/
7/
04
15
VII.
OPP/
GHS
CLASSIFICATION
CRITERIA
AND
LABELING
COMPARISON:

ENVIRONMENTAL
HAZARDS
Summary
Comparison:.

$
GHS
covers
only
one
environmental
hazard:
aquatic
toxicity.
Work
to
develop
terrestrial
toxicity
as
a
GHS
hazard
class
may
proceed
in
the
future.
In
the
meantime,
OPP
labeling
for
hazards
other
than
aquatic
toxicity
(
e.
g.,
bees,
mammals)
may
be
considered
"
supplemental
information,"
consistent
with
but
not
part
of
the
GHS.

$
The
GHS
has
three
acute
and
four
chronic
categories
for
aquatic
toxicity.
Categories
1­
3
of
chronic
toxicity
are
based
on
combining
the
criteria
for
Categories
1­
3
acute
toxicity
with
criteria
for
persistence
in
the
aquatic
environment.
Category
4
chronic
toxicity
is
based
on
persistence
alone,
in
the
absence
of
toxicity
data.
OPP
does
not
now
label
chronic
aquatic
toxicity.

$
OPP
requires
no
signal
word
or
symbol
for
aquatic
toxicity.
The
GHS
specifies
the
"
dead
fish
and
tree"
symbol
and
the
signal
word
"
warning"
for
Category
1
acute
toxicity
and
Category
1
chronic
toxicity.
For
Category
2
chronic
toxicity,
the
GHS
specifies
the
symbol
but
no
signal
word.

$
OPP
requires
the
hazard
statement
"
this
pesticide
is
toxic
to
fish"
based
on
studies
showing
that
the
active
ingredient
has
a
fish
acute
toxicity
LC­
50
of
1
ppm
or
less,
if
the
pesticide
is
intended
for
outdoor
use.
OPP
requires
the
statement
"
this
pesticide
is
extremely
toxic
to
fish"
if
there
are
field
studies
or
accident
data
(
such
as
FIFRA
6(
a)
2
reports)
showing
fish
kills.
OPP
also
requires
specific
hazard/
precautionary
statements
for
a
number
of
individual
pesticides.
The
GHS
sets
out
toxicity
and
persistence
criteria
for
each
hazard
category,
and
accompanying
hazard
statements.

$
GHS
testing
protocols
for
aquatic
toxicity
are
still
in
the
process
of
validation.
DRAFT
7/
7/
04
16
OPP
Criteria,
Signal
Words,
Symbol,
and
Hazard
Statements
GHS
Criteria,
Signal
Word,
Pictograms
and
Label
Statements
FISH
ACUTE
TOXICITY
Field
studies
or
accident
history,
such
as
the
FIFRA
6(
a)(
2)
reports,
indicate
that
use
of
the
pesticide
may
result
in
fatality
to
fish.

No
signal
word
No
symbol
This
pesticide
is
extremely
toxic
to
fish.

Fish
acute
LC
50

1
ppm
No
signal
word
No
symbol
This
pesticide
is
toxic
to
fish.
HAZARDOUS
TO
THE
AQUATIC
ENVIRONMENT
Acute
Toxicity
Category
1
96
hr
LC
50
(
fish)

1
mg/
L
48
hr
EC
50
(
crustacea)

1
mg/
L
72/
96
hr
ErC
50
(
aquatic
plants)

1
mg/
L
WARNING
Fish
and
tree
in
diamond
Very
toxic
to
aquatic
life
Acute
Toxicity
Category
2
96
hr
LC
50
(
fish)
>
1

10
mg/
L
48
hr
EC
50
(
crustacea)
>
1

10
mg/
L
72/
96
hr
ErC
50
(
aquatic
plants)
>
1

10
mg/
L
No
signal
word
No
symbol
is
used
Toxic
to
aquatic
life
Acute
Toxicity
Category
3
96
hr
LC
50
(
fish)
>
10

100
mg/
L
48
hr
EC
50
(
crustacea)
>
10

100
mg/
L
72/
96
hr
ErC
50
(
aquatic
plants)
>
10

100
mg/
L
No
signal
word
No
symbol
is
used
Harmful
to
aquatic
life
DRAFT
7/
7/
04
17
Chronic
toxicity
(
see
GHS
document
Chapter
3.10
for
persistence
criteria)
Category
1
WARNING
Fish
and
tree
in
diamond
border
Very
toxic
to
aquatic
life
with
long
lasting
effects
Category
2
No
signal
word
Fish
and
tree
in
diamond
border
Toxic
to
aquatic
life
with
long
lasting
effects
Category
3
No
signal
word
No
symbol
Harmful
to
aquatic
life
with
long
lasting
effects
Category
4
No
signal
word
No
symbol
May
cause
long
lasting
harmful
effects
to
aquatic
life
DRAFT
7/
7/
04
18
VIII.
OPP/
GHS
CLASSIFICATION
CRITERIA
AND
LABELING
COMPARISON:

FLAMMABILITY
Summary
Comparison:

$
Both
OPP
and
GHS
specify
test
methods
and
set
criteria
based
on
test
results.

$
OPP
classification
criteria
are
based
on
flashpoint
(
all
pesticides)
and
flash
extension
tests
(
pressurized
containers).
There
are
three
categories
for
pressurized
containers,
and
four
for
nonpressurized
containers.

$
GHS
specifies
criteria
and
label
elements
for
two
categories
of
flammable
gases,
two
categories
of
flammable
aerosols,
four
categories
of
flammable
liquids,
and
two
categories
of
flammable
solids.
OPP
does
not
distinguish
based
on
physical
state.

$
OPP
uses
no
signal
words
and
no
symbol,
except
that
a
flame
symbol
is
required
for
total
release
fogger
products
(
40
CFR
156.78(
d)(
3)).
GHS
uses
the
"
danger"
signal
word
for
Category
1
flammable
solids,
gases
and
aerosols
and
Categories
1
and
2
flammable
liquids;
and
the
signal
word
"
warning"
for
Category
2
flammable
solids,
gases
and
aerosols
and
Categories
3
and
4
flammable
liquids.
The
GHS
uses
the
flame
symbol
for
Category
1
flammable
gases,
Categories
1
and
2
flammable
aerosols,
Categories
1­
3
flammable
liquids,
and
Categories
1
and
2
flammable
solids.
DRAFT
7/
7/
04
19
OPP
Criteria,
Signal
Words,
Symbol,
and
Hazard
Statements
GHS
Criteria,
Signal
Word,
Pictograms,
and
Label
Statements
FLAMMABILITY
Pressurized
Containers
Flash
point
<
20
degrees
F;
if
there
is
a
flashback
at
any
valve
opening.
No
signal
word
No
symbol
Extremely
flammable
Flash
point
>
20
degrees
F
and
<
80
degrees
F
or
if
the
flame
extension
is
more
than
18"
long
at
a
distance
of
6"
from
the
flame.
No
signal
word
No
symbol
Flammable
All
other
pressurized
containers.
No
signal
word
No
symbol
Contents
under
pressure
(
plus
other
precautionary
language)

Nonpressurized
Containers
Flashpoint
<
20
degrees
F.
No
signal
word
No
symbol
Extremely
flammable
20
degrees
F<
flashpoint
<
80
degrees
F.
No
signal
word
No
symbol
Flammable
80
degrees
F
<
flashpoint<
150
degrees
F
No
signal
word
No
symbol
Combustible
FLAMMABLE
LIQUIDS
Category
1
Flash
point
<
23
degrees
C
and
initial
boiling
point

35
degrees
C.
DANGER
Flame
in
diamond
Extremely
flammable
liquid
and
vapour
Category
2
Flash
point
<
23
degrees
C
and
initial
boiling
point
>
35
degrees
C.
DANGER
Flame
in
diamond
Highly
flammable
liquid
and
vapour
Category
3
Flash
point

23
degrees
C

60
degrees
C.
WARNING
Flame
in
diamond
Flammable
liquid
and
vapour
Category
4
Flash
point
>
60
degrees
C

93
degrees
C.
WARNING
No
symbol
Combustible
liquid
DRAFT
7/
7/
04
20
Flammability
for
Nonpressurized
Containers
(
cont.)

Flashpoint
>
150
degrees
F.
No
signal
word.
No
symbol
No
hazard
statement
or
other
text
required.
FLAMMABLE
AEROSOLS
See
GHS
Document
Chapter
2.3
for
detailed
classification
criteria.

Category
1
DANGER
Flame
in
diamond.
Extremely
flammable
aerosol
Category
2
WARNING
Flame
in
diamond
Flammable
aerosol
FLAMMABLE
SOLIDS
Category
1
Using
the
burning
rate
test,
substances
or
mixtures
other
than
metal
powders:
(
a)
wetted
zone
does
not
stop
fire
and
(
b)
burning
time
<
45
seconds
or
burning
rate
>
2.2
mm/
second
Using
the
burning
rate
test,
metal
powders
that
have
burning
time

5
minutes
DANGER
Flame
in
diamond
Flammable
solid
Category
2
Using
the
burning
rate
test,
substances
or
mixtures
other
than
metal
powders:
(
a)
wetted
zone
does
not
stop
fire
for
at
least
4
minutes
and
(
b)
burning
time
<
45
seconds
or
burning
rate
>
2.2
mm/
second
Using
the
burning
rate
test,
metal
powders
that
have
burning
time
>
5

10
minutes
WARNING
Flame
in
diamond
Flammable
solid
DRAFT
7/
7/
04
21
FLAMMABLE
GASES
Category
1
Gases,
which
at
20
degrees
C
and
a
standard
pressure
of
101.3
kPA:
(
a)
are
ignitable
when
in
a
mixture
of
13%
or
less
by
volume
in
air;
or
(
b)
have
a
flammable
range
with
air
of
at
least
12
percentage
points
regardless
of
the
lower
flammable
limit.
DANGER
Flame
in
diamond
Extremely
flammable
gas
Category
2
Gases,
other
than
those
of
category
1,
which,
at
20
degrees
C
and
a
standard
pressure
of
101.3
kPA,
have
a
flammable
range
while
mixed
in
air.
WARNING
No
symbol
used
Flammable
gas
DRAFT
7/
7/
04
22
IX.
OPP/
GHS
CLASSIFICATION
CRITERIA
AND
LABELING
COMPARISON:

OTHER
PHYSICAL
OR
CHEMICAL
HAZARDS
Summary
Comparison:

$
OPP
does
not
specify
classification
criteria,
symbols,
signal
words
or
label
statements
for
physical
hazards
other
than
flammability
but
notes
that
when
data
demonstrate
such
hazards,
(
for
example,
explosivity),
appropriate
hazard
statements
must
appear
on
the
label.

$
Part
2
of
the
GHS
document
specifies
classification
criteria
and
label
elements
for
explosives,
oxidizers,
compressed
gases,
self­
reactive
and
self­
heating
substances,
pyrophoric
liquids
and
solids,
substances
which
emit
flammable
gases
in
contact
with
water,
organic
peroxides,
and
metal
corrosives.

$
To
be
consistent
with
the
GHS,
OPP
would
need
to
adopt
the
GHS
criteria
and
label
elements,
as
well
as
the
associated
test
methods,
for
each
the
physical/
chemical
hazard
class
or
category
it
decides
to
cover.