Document ID: EPA-HQ-OPP-2006-0165-0005
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2006-08-23T04:00Z

Dimethenamid­
p
Dietary
Exposure
Assessment
DP
Num:
318282
PC
Code:
129051
Page:
1
of
14
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
MEMORANDUM
DATE:
June
14,
2006
SUBJECT:
Dimethenamid­
p
Acute
and
Chronic
Dietary
Exposure
Assessments
for
the
Section
3
Registration
Action.

PC
Code:
129051
DP
Num:
318282
REVIEWER:
Shaja
R.
Brothers,
Environmental
Protection
Specialist
Risk
Integration
Minor
Use
and
Emergency
Response
Branch/
Registration
Division
(
7505P)

THROUGH:
William
Cutchin,
Chemist
ARIA
Technical
Review
Branch/
Registration
Division
(
7505P)

Jose
Morales,
Chemist
Leung
Cheng,
Chemist
Health
Effects
Division
(
7509P)

TO:
Christina
Swartz,
Branch
Chief
Registration
Action
Branch
2
Health
Effects
Division
(
7509P)

Executive
Summary
Acute
and
chronic
dietary
risk
assessments
were
conducted
using
the
Dietary
Exposure
Evaluation
Model
(
DEEM­
FCID
 
,
Version
2.03),
which
uses
food
consumption
data
from
the
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII)
from
1994­
1996
and
1998.
The
analyses
were
performed
to
support
Section
3
requests
for
the
use
of
dimethenamid­
p
on
bulb
vegetable
commodities
(
PP#
4E6844).

Acute
Dietary
Exposure
Results
and
Characterization
An
acute
Tier
1
dietary
analysis
(
assuming
tolerance
level
residues)
default
processing
factors,
and
Dimethenamid­
p
Dietary
Exposure
Assessment
DP
Num:
318282
PC
Code:
129051
Page:
2
of
14
100
percent
crop
treated
(%
CT)
information
was
conducted
for
dimethenamid­
p.
The
highest
drinking
water
estimate
for
acute
exposure,
49
ppb,
was
used
in
the
analysis.
This
analysis
incorporates
all
current,
and
proposed
tolerances
for
dimethenamid­
p
as
of
October
28,
2005.
Risk
estimates
due
to
acute
dietary
exposure
from
food
using
the
Tier
1
analysis
for
the
subgroup
Females
13­
50
are
less
than
1%
of
the
aPAD,
which
is
below
the
Agency's
level
of
concern.

Chronic
Dietary
Exposure
Results
and
Characterization
A
chronic
Tier
1
dietary
analysis
(
assuming
tolerance
level
residues)
default
processing
factors,
and
100
percent
crop
treated
(%
CT)
information
was
conducted
for
dimethenamid­
p.
The
highest
drinking
water
estimate
for
chronic
exposure,
7.9
ppb,
was
used
in
the
analysis.
This
analysis
incorporates
all
current,
and
proposed
tolerances
for
dimethenamid­
p
as
of
October
28,
2005.
Risk
estimates
due
to
chronic
dietary
exposure
from
food
using
the
Tier
1
analysis
for
the
subgroup,
all
infants
(<
1
year
old),
utilized
1%
or
less
of
the
aPAD,
which
is
below
the
Agency's
level
of
concern.

Cancer
Dietary
Exposure
Results
and
Characterization
Dimethenamid­
p
is
a
category
C
possible
human
carcinogen
not
requiring
any
type
of
quantitative
cancer
risk
assessment.

I.
Introduction
Dietary
risk
assessment
incorporates
both
exposure
and
toxicity
of
a
given
pesticide.
For
acute
and
chronic
assessments,
the
risk
is
expressed
as
a
percentage
of
a
maximum
acceptable
dose
(
i.
e.,
the
dose
which
HED
has
concluded
will
result
in
no
unreasonable
adverse
health
effects).
This
dose
is
referred
to
as
the
population
adjusted
dose
(
PAD).
The
PAD
is
equivalent
to
the
Reference
Dose
(
RfD)
divided
by
the
special
FQPA
Safety
Factor.

For
acute
and
non­
cancer
chronic
exposures,
HED
is
concerned
when
estimated
dietary
risk
exceeds
100%
of
the
PAD.
HED
is
generally
concerned
when
estimated
cancer
risk
exceeds
one
in
one
million
(
i.
e.,
the
risk
exceeds
1
x
10­
6).
References
which
discuss
the
acute
and
chronic
risk
assessments
in
more
detail
are
available
on
the
EPA/
pesticides
web
site:
"
Available
Information
on
Assessing
Exposure
from
Pesticides,
A
User's
Guide,"
6/
21/
2000,
web
link:
http://
www.
epa.
gov/
fedrgstr/
EPA­
PEST/
2000/
July/
Day­
12/
6061.
pdf
;
or
see
SOP
99.6
(
8/
20/
99).

The
most
recent
dietary
risk
assessment
for
dimethenamid­
p
was
conducted
by
C.
Swartz
et.
al.
(
1/
24/
2006,
D314487).

II.
Residue
Information
Dimethenamid­
p
Dietary
Exposure
Assessment
DP
Num:
318282
PC
Code:
129051
Page:
3
of
14
Dimethenamid­
p:
2­
chloro­
N­[(
1­
methyl­
2­
methoxy)
ethyl]­
N­(
2,4­
dimethyl­
thien­
3­
yl)­
acetamide
is
a
synthetic
herbicide
for
which
tolerances
have
been
established
(
40
CFR
180.464)
at
0.01
ppm
in
bean,
dry,
seed;
beet,
garden,
roots;
beet,
garden,
tops;
beet,
sugar,
dried
pulp;
beet,
sugar,
molasses;
beet,
sugar,
roots;
beet,
sugar,
tops;
corn,
field,
forage;
corn,
field,
grain;
corn,
field,
stover;
corn,
pop,
forage;
corn,
pop,
grain;
corn,
pop,
stover;
corn
sweet,
forage;
corn,
sweet,
kernel
plus
cobs
with
husk
removed;
corn,
sweet,
stover;
garlic;
horseradish;
onion,
dry
bulb;
peanut,
hay;
peanut,
nutmeat;
shallot,
bulb;
sorghum,
grain;
sorghum,
grain,
forage;
sorghum,
grain,
stover;
soybean,
seed;
and
tuberous
and
corm
vegetables.
The
residue
of
concern
for
enforcement
and
risk
assessment
purposes
is
dimethenamid­
p
per
se.
As
part
of
the
current
petition,
ARIA
recommended
establishing
the
permanent
tolerances
below
1
for
residues
of
dimethenamid­
p:

Commodity
Recommended
Tolerance
(
ppm)

Onion,
green
0.01
Leek
0.01
Onion,
Welsh
0.01
Shallot,
fresh
leaves
0.01
The
following
conservative
assumptions
were
made
for
the
chronic
dietary
analysis:
HED
recommended
tolerance
level
residues
(
associated
with
the
current
petition
and
previously
registered
uses),
DEEM
 
default
processing
factors
for
all
RACs,
and
assumed
all
RACs
were
100%
treated
with
dimethenamid­
p.

Drinking
water
concentrations
have
been
predicted
using
a
standard
Georgia
onion
scenario
as
a
surrogate
for
use
on
all
crops,
using
acceptable
environmental
fate
and
transport
data
submitted
to
the
Agency.
Tier
II
surface
water
concentrations
are
predicted
by
the
PRZM/
EXAMS
model
at
49
ug/
L
for
acute
exposure,
7.9
ug/
L
for
non­
cancer
chronic
exposure,
and
5.1
ug/
L
for
overall
chronic
exposure.
Ground
water
concentrations
of
0.42
ug/
L
were
predicted
by
the
Tier
I
model,
SCIGROW.
This
assessment
is
for
the
parent
compound
only.

III
Program
and
Consumption
Information
IIIa.
DEEM­
FCID
 
Program
and
Consumption
Information
Dimethenamid­
p
acute
and
chronic
dietary
exposure
assessments
were
conducted
using
the
Dietary
Exposure
Evaluation
Model
software
with
the
Food
Commodity
Intake
Database
Dimethenamid­
p
Dietary
Exposure
Assessment
DP
Num:
318282
PC
Code:
129051
Page:
4
of
14
(
DEEM­
FCID
 
,
Version
2.03),
which
incorporates
consumption
data
from
USDA's
Continuing
Surveys
of
Food
Intakes
by
Individuals
(
CSFII),
1994­
1996
and
1998.
The
1994­
96,
98
data
are
based
on
the
reported
consumption
of
more
than
20,000
individuals
over
two
non­
consecutive
survey
days.
Foods
"
as
consumed"
(
e.
g.,
apple
pie)
are
linked
to
EPA­
defined
food
commodities
(
e.
g.
apples,
peeled
fruit
­
cooked;
fresh
or
N/
S;
baked;
or
wheat
flour
­
cooked;
fresh
or
N/
S,
baked)
using
publicly
available
recipe
translation
files
developed
jointly
by
USDA/
ARS
and
EPA.
For
chronic
exposure
assessment,
consumption
data
are
averaged
for
the
entire
U.
S.
population
and
within
population
subgroups,
but
for
acute
exposure
assessment
are
retained
as
individual
consumption
events.
Based
on
analysis
of
the
1994­
96,
98
CSFII
consumption
data,
which
took
into
account
dietary
patterns
and
survey
respondents,
HED
concluded
that
it
is
most
appropriate
to
report
risk
for
the
following
population
subgroups:
the
general
U.
S.
population,
all
infants
(<
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
adults
20­
49,
females
13­
49,
and
adults
50+
years
old.

For
chronic
dietary
exposure
assessment,
an
estimate
of
the
residue
level
in
each
food
or
foodform
(
e.
g.,
orange
or
orange
juice)
on
the
food
commodity
residue
list
is
multiplied
by
the
average
daily
consumption
estimate
for
that
food/
food
form
to
produce
a
residue
intake
estimate.
The
resulting
residue
intake
estimate
for
each
food/
food
form
is
summed
with
the
residue
intake
estimates
for
all
other
food/
food
forms
on
the
commodity
residue
list
to
arrive
at
the
total
average
estimated
exposure.
Exposure
is
expressed
in
mg/
kg
body
weight/
day
and
as
a
percent
of
the
cPAD.
This
procedure
is
performed
for
each
population
subgroup.

For
acute
exposure
assessments,
individual
one­
day
food
consumption
data
are
used
on
an
individual­
by­
individual
basis.
The
reported
consumption
amounts
of
each
food
item
can
be
multiplied
by
a
residue
point
estimate
and
summed
to
obtain
a
total
daily
pesticide
exposure
for
a
deterministic
exposure
assessment,
or
"
matched"
in
multiple
random
pairings
with
residue
values
and
then
summed
in
a
probabilistic
assessment.
The
resulting
distribution
of
exposures
is
expressed
as
a
percentage
of
the
aPAD
on
both
a
user
(
i.
e.,
only
those
who
reported
eating
relevant
commodities/
food
forms)
and
a
per­
capita
(
i.
e.,
those
who
reported
eating
the
relevant
commodities
as
well
as
those
who
did
not)
basis.
In
accordance
with
HED
policy,
per
capita
exposure
and
risk
are
reported
for
all
tiers
of
analysis.
However,
for
tiers
1
and
2,
any
significant
differences
in
user
vs.
per
capita
exposure
and
risk
are
specifically
identified
and
noted
in
the
risk
assessment.

IV.
Toxicological
Information
FQPA
safety
factor.
Based
on
the
hazard
data,
HED
recommended
the
special
FQPA
SF
be
reduced
to
1X
because
there
are
low
concerns,
and
no
residual
uncertainties
with
regard
to
preand
or
postnatal
toxicity.
Also,
based
on
the
quality
of
the
exposure
data,
the
dimethenamid­
p
risk
assessment
team
recommended
that
the
special
FQPA
SF
be
reduced
to
1X.
The
recommendation
is
based
on
the
following:
1)
the
dietary
food
exposure
assessment
utilizes
proposed
tolerance
level
residues
and
100%
CT
information
for
all
commodities.
By
using
these
screening­
level
assessments,
acute
and
chronic
exposure
will
not
be
underestimated,
and
2)
the
Dimethenamid­
p
Dietary
Exposure
Assessment
DP
Num:
318282
PC
Code:
129051
Page:
5
of
14
dietary
drinking
water
assessment
(
Tier
2
estimates)
utilizes
values
generated
by
model
and
associated
modeling
parameters
which
are
designed
to
provide
health
protective,
high­
end
estimates
of
water
concentrations.

Acute
Dietary
Exposure.
NOAEL
is
75
mg/
kg/
day.
LOAEL
is
150
mg/
kg/
day
based
on
developmental
effects
of
increased
resorptions,
implantation
loss
and
angulated
hyoid
alae.
The
resorptions
and
post
implantation
loss
is
presumed
to
be
a
single
dose
effect.
The
developmental
endpoint
is
appropriate
for
females
13­
49
and
is
of
the
appropriate
duration.
The
endpoint
is
supported
by
a
range­
finding
study
in
rats
with
[
S]­
dimethenamid­
P,
which
showed
increased
resorptions
at
400
mg/
kg/
day.

An
appropriate
acute
endpoint
attributable
to
a
single
dose
was
not
available
for
the
general
population
in
the
toxicity
data
base
including
the
developmental
toxicity
studies.

Chronic
Dietary
Exposure.
NOAEL
is
5.1/
6.8
mg/
kg/
day
for
male/
female.
The
LOAEL
is
36/
49
mg/
kg/
day
for
male/
female
based
on
decreased
body
weight
and
body
weight
gain
from
week
1­
10
and
week
10­
104
in
both
sexes,
and
at
termination
increased
microscopic
hepatic
lesions
in
both
sexes.

Table
1.
Summary
of
Toxicological
Dose
and
Endpoints
for
Dimethenamid­
p
for
Use
in
Dietary
Exposure
Assessment
Exposure
Scenario
Dose
Used
in
Risk
Assessment,
UF
Special
FQPA
SF
and
Level
of
Concern
for
Risk
Assessment
Study
and
Toxicological
Effects
Acute
Dietary
(
Females
13­
49
years
of
age)

Based
on
[
RS]
data
NOAEL
=
75
mg/
kg/
day
UF
=
100
Acute
RfD
=
0.75
mg/
kg/
day
FQPA
SF
=
1X
aPAD
=
acute
RfD
FQPA
SF
=
0.75
mg/
kg/
day
Developmental
Toxicity
in
rabbits
Maternal
LOAEL
=
150
mg/
kg/
day
based
on
abortions
and
decreased
body
weight
gain
and
food
consumption.
Developmental;
LOAEL
=
150
mg/
kg/
day
based
on
post­
implantation
loss
Acute
Dietary
(
General
population
including
infants
and
children)
Not
Applicable
No
studies
identify
an
acute
hazard
(
dose
and
endpoint)
based
on
a
single
oral
exposure
(
dose)
Dimethenamid­
p
Dietary
Exposure
Assessment
DP
Num:
318282
PC
Code:
129051
Page:
6
of
14
Table
1.
Summary
of
Toxicological
Dose
and
Endpoints
for
Dimethenamid­
p
for
Use
in
Dietary
Exposure
Assessment
Exposure
Scenario
Dose
Used
in
Risk
Assessment,
UF
Special
FQPA
SF
and
Level
of
Concern
for
Risk
Assessment
Study
and
Toxicological
Effects
Chronic
Dietary
(
All
populations)

Based
on
[
RS]
data
NOAEL=
5
mg/
kg/
day
UF
=
100
Chronic
RfD
=
0.05
mg/
kg/
day
FQPA
SF
=
1X
cPAD
=
chronic
RfD
FQPA
SF
=
0.05
mg/
kg/
day
Chronic/
carcinogenicity
rats
LOAEL
=
M/
F;
36/
49
mg/
kg/
day
based
on
decreased
body
weight
and
body
weight
gain
in
both
sexes,
increased
food
conversion
ratios
in
females,
and
increased
microscopic
hepatic
lesions
in
both
sexes.

Carcinogenicity
Based
on
[
RS]
data
"
C"
Possible
human
carcinogen.
(
No
Q1*)

V.
Results/
Discussion
As
stated
above,
for
acute
and
chronic
assessments,
HED
is
concerned
when
dietary
risk
exceeds
100%
of
the
PAD.
The
DEEM­
FCID
 
analyses
estimate
the
dietary
exposure
of
the
U.
S.
population
and
various
population
subgroups.
The
results
reported
are
for
the
general
U.
S.
Population,
all
infants
(<
1
year
old),
children
1­
2,
children
3­
5,
children
6­
12,
youth
13­
19,
females
13­
49,
adults
20­
49,
and
adults
50+
years.
Cancer
risk
is
determined
for
the
general
U.
S.
population
only.

Results
of
Acute
Dietary
Exposure
Analysis
Results
are
reported
at
the
95th
percentile
of
exposure
because
the
assessment
incorporated
tolerance
level
residues
and
100%
CT
assumptions.
The
estimated
acute
(
one
day)
aggregate
food
and
water
exposure
of
females
13­
49
years
old
is
less
than
1%
of
the
dimethenamid­
p
aPAD.

Table
2.
Results
of
Acute
Dietary
Exposure
Analysis
at
the
95th
Percentile
of
Exposure
Population
Subgroup
aPAD
(
mg/
kg/
day)
Exposure
(
mg/
kg/
day)
%
aPAD
Females
13­
50
0.75
0.002417
<
1
Dimethenamid­
p
Dietary
Exposure
Assessment
DP
Num:
318282
PC
Code:
129051
Page:
7
of
14
Results
of
Chronic
Dietary
Exposure
Analysis
The
estimated
chronic
aggregate
food
and
water
dietary
risk
estimates
for
all
population
subgroups
utilized
1%
or
less
of
the
dimethenamid­
p
cPAD
(
0.05
mg/
kg/
day).

Table
3.
Results
of
Chronic
Dietary
Exposure
Analysis
Population
Subgroup
cPAD
(
mg/
kg/
day)
Exposure
(
mg/
kg/
day)
%
cPAD
General
U.
S.
Population
0.05
0.000205
<
1
All
Infants
(<
1
year
old)
0.05
0.000605
1
Children
1­
2
years
old
0.05
0.000329
<
1
Children
3­
5
years
old
0.05
0.000316
<
1
Children
6­
12
years
old
0.05
0.000221
<
1
Youth
13­
19
years
old
0.05
0.000163
<
1
Adults
20­
49
years
old
0.05
0.000187
<
1
Females
13­
49
years
old
0.05
0.000185
<
1
Adults
50+
years
old
0.05
0.000187
<
1
Results
of
Cancer
Dietary
Exposure
Analysis
Dimethenamid
is
a
category
C
possible
human
carcinogen
not
requiring
any
type
of
quantitative
cancer
risk
assessment.

VII.
Conclusions
The
acute
dietary
exposure
and
risk
assessment
indicates
that
for
all
included
commodities,
the
acute
dietary
risk
estimates
are
below
HED's
level
of
concern
(<
100%
aPAD)
for
females
13­
50
at
less
than
1%
of
the
aPAD.
Additional
refinement
using
%
CT
data
and
additional
processing
factors
would
result
in
even
lower
exposure
estimates.

The
chronic
dietary
exposure
and
risk
assessment
also
indicates
that
for
all
included
commodities,
the
chronic
dietary
risk
estimates
are
below
HED's
level
of
concern
(<
100%
cPAD)
for
the
general
U.
S.
population
(<
1%
of
the
cPAD)
and
all
population
subgroups.
The
chronic
dietary
exposure
estimate
for
the
highest
exposed
population
subgroup
(
all
infants
<
1
year
old)
is
1%
or
less
of
the
cPAD.
Refinement
using
ARs,
processing
factors,
and
%
CT
data
would
result
in
even
lower
chronic
exposure
estimates.
Dimethenamid­
p
Dietary
Exposure
Assessment
DP
Num:
318282
PC
Code:
129051
Page:
8
of
14
VIII.
List
of
Attachments
Attachment
1:
Acute
Input
File
Attachment
2:
Acute
Output
File
Attachment
3:
Chronic
Input
File
Attachment
4:
Chronic
Output
File
Dimethenamid­
p
Dietary
Exposure
Assessment
DP
Num:
318282
PC
Code:
129051
Page:
9
of
14
Attachment
1:
Acute
Input
File
Filename:
E:\
working\
Dimetheneamid\
120051a.
R98
Chemical:
Dimethenamide
RfD(
Chronic):
.05
mg/
kg
bw/
day
NOEL(
Chronic):
0
mg/
kg
bw/
day
RfD(
Acute):
.75
mg/
kg
bw/
day
NOEL(
Acute):
0
mg/
kg
bw/
day
Date
created/
last
modified:
02­
17­
2006/
19:
50:
30/
8
Program
ver.
2.03
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
EPA
Crop
Def
Res
Adj.
Factors
Comment
Code
Grp
Commodity
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
95002630
O
Peanut
0.010000
1.000
1.000
95002640
O
Peanut,
butter
0.010000
1.000
1.000
95002650
O
Peanut,
oil
0.010000
1.000
1.000
86010000
O
Water,
direct,
all
sources
0.049000
1.000
1.000
86020000
O
Water,
indirect,
all
sources
0.049000
1.000
1.000
01030150
1CD
Arrowroot,
flour
0.010000
1.000
1.000
01030151
1CD
Arrowroot,
flour­
babyfood
0.010000
1.000
1.000
01030170
1CD
Artichoke,
Jerusalem
0.010000
1.000
1.000
01010500
1AB
Beet,
garden,
roots
0.010000
1.000
1.000
01010501
1AB
Beet,
garden,
roots­
babyfood
0.010000
1.000
1.000
01010520
1A
Beet,
sugar
0.010000
1.000
1.000
01010521
1A
Beet,
sugar­
babyfood
0.010000
1.000
1.000
01010530
1A
Beet,
sugar,
molasses
0.010000
1.000
1.000
01010531
1A
Beet,
sugar,
molasses­
babyfood
0.010000
1.000
1.000
01030820
1CD
Cassava
0.010000
1.000
1.000
01030821
1CD
Cassava­
babyfood
0.010000
1.000
1.000
01031390
1CD
Dasheen,
corm
0.010000
1.000
1.000
01031660
1CD
Ginger
0.010000
1.000
1.000
01031661
1CD
Ginger­
babyfood
0.010000
1.000
1.000
01031670
1CD
Ginger,
dried
0.010000
1.000
1.000
01011900
1AB
Horseradish
0.010000
1.000
1.000
01032960
1C
Potato,
chips
0.010000
1.000
1.000
01032970
1C
Potato,
dry
(
granules/
flakes)
0.010000
1.000
1.000
01032971
1C
Potato,
dry
(
granules/
flakes)­
b
0.010000
1.000
1.000
01032980
1C
Potato,
flour
0.010000
1.000
1.000
01032981
1C
Potato,
flour­
babyfood
0.010000
1.000
1.000
01032990
1C
Potato,
tuber,
w/
peel
0.010000
1.000
1.000
01032991
1C
Potato,
tuber,
w/
peel­
babyfood
0.010000
1.000
1.000
01033000
1C
Potato,
tuber,
w/
o
peel
0.010000
1.000
1.000
01033001
1C
Potato,
tuber,
w/
o
peel­
babyfood
0.010000
1.000
1.000
01033660
1CD
Sweet
potato
0.010000
1.000
1.000
01033661
1CD
Sweet
potato­
babyfood
0.010000
1.000
1.000
01033710
1CD
Tanier,
corm
0.010000
1.000
1.000
01033870
1CD
Turmeric
0.010000
1.000
1.000
01034060
1CD
Yam,
true
0.010000
1.000
1.000
01034070
1CD
Yam
bean
0.010000
1.000
1.000
02000510
2
Beet,
garden,
tops
0.010000
1.000
1.000
02001400
2
Dasheen,
leaves
0.010000
1.000
1.000
03001640
3
Garlic
0.010000
1.000
1.000
03001650
3
Garlic,
dried
0.010000
1.000
1.000
03001651
3
Garlic,
dried­
babyfood
0.010000
1.000
1.000
03001980
3
Leek
0.010000
1.000
1.000
03002370
3
Onion,
dry
bulb
0.010000
1.000
1.000
03002371
3
Onion,
dry
bulb­
babyfood
0.010000
1.000
1.000
03002380
3
Onion,
dry
bulb,
dried
0.010000
1.000
1.000
03002381
3
Onion,
dry
bulb,
dried­
babyfood
0.010000
1.000
1.000
03002390
3
Onion,
green
0.010000
1.000
1.000
03003380
3
Shallot
0.010000
1.000
1.000
06030300
6C
Bean,
black,
seed
0.010000
1.000
1.000
06030320
6C
Bean,
broad,
seed
0.010000
1.000
1.000
06030340
6C
Bean,
cowpea,
seed
0.010000
1.000
1.000
06030350
6C
Bean,
great
northern,
seed
0.010000
1.000
1.000
06030360
6C
Bean,
kidney,
seed
0.010000
1.000
1.000
06030380
6C
Bean,
lima,
seed
0.010000
1.000
1.000
06030390
6C
Bean,
mung,
seed
0.010000
1.000
1.000
06030400
6C
Bean,
navy,
seed
0.010000
1.000
1.000
06030410
6C
Bean,
pink,
seed
0.010000
1.000
1.000
06030420
6C
Bean,
pinto,
seed
0.010000
1.000
1.000
06030980
6C
Chickpea,
seed
0.010000
1.000
1.000
06030981
6C
Chickpea,
seed­
babyfood
0.010000
1.000
1.000
06030990
6C
Chickpea,
flour
0.010000
1.000
1.000
06003470
6
Soybean,
seed
0.010000
1.000
1.000
06003480
6
Soybean,
flour
0.010000
1.000
1.000
06003481
6
Soybean,
flour­
babyfood
0.010000
1.000
1.000
06003490
6
Soybean,
soy
milk
0.010000
1.000
1.000
Dimethenamid­
p
Dietary
Exposure
Assessment
DP
Num:
318282
PC
Code:
129051
Page:
10
of
14
06003491
6
Soybean,
soy
milk­
babyfood
or
in
0.010000
1.000
1.000
06003500
6
Soybean,
oil
0.010000
1.000
1.000
06003501
6
Soybean,
oil­
babyfood
0.010000
1.000
1.000
09023570
9B
Squash,
winter
0.010000
1.000
1.000
09023571
9B
Squash,
winter­
babyfood
0.010000
1.000
1.000
15001200
15
Corn,
field,
flour
0.010000
1.000
1.000
15001201
15
Corn,
field,
flour­
babyfood
0.010000
1.000
1.000
15001210
15
Corn,
field,
meal
0.010000
1.000
1.000
15001211
15
Corn,
field,
meal­
babyfood
0.010000
1.000
1.000
15001220
15
Corn,
field,
bran
0.010000
1.000
1.000
15001230
15
Corn,
field,
starch
0.010000
1.000
1.000
15001231
15
Corn,
field,
starch­
babyfood
0.010000
1.000
1.000
15001240
15
Corn,
field,
syrup
0.010000
1.000
1.000
15001241
15
Corn,
field,
syrup­
babyfood
0.010000
1.000
1.000
15001250
15
Corn,
field,
oil
0.010000
1.000
1.000
15001251
15
Corn,
field,
oil­
babyfood
0.010000
1.000
1.000
15001260
15
Corn,
pop
0.010000
1.000
1.000
15001270
15
Corn,
sweet
0.010000
1.000
1.000
15001271
15
Corn,
sweet­
babyfood
0.010000
1.000
1.000
15003440
15
Sorghum,
grain
0.010000
1.000
1.000
Dimethenamid­
p
Dietary
Exposure
Assessment
DP
Num:
318282
PC
Code:
129051
Page:
11
of
14
Attachment
2:
Acute
Output
File
U.
S.
Environmental
Protection
Agency
Ver.
2.02
DEEM­
FCID
ACUTE
Analysis
for
DIMETHENAMIDE
(
1994­
98
data)
Residue
file:
120051a.
R98
Adjustment
factor
#
2
NOT
used.
Analysis
Date:
06­
14­
2006/
15:
20:
33
Residue
file
dated:
06­
14­
2006/
15:
18:
10/
8
Daily
totals
for
food
and
foodform
consumption
used.
Run
Comment:
""
===============================================================================

Summary
calculations
(
per
capita):

95th
Percentile
99th
Percentile
99.9th
Percentile
Exposure
%
aRfD
Exposure
%
aRfD
Exposure
%
aRfD
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
­­­­­­­­­­
­­­­­­­­
Females
13­
49
yrs:
0.002417
0.32
0.003843
0.51
0.006859
0.91
Dimethenamid­
p
Dietary
Exposure
Assessment
DP
Num:
318282
PC
Code:
129051
Page:
12
of
14
Attachment
3:
Chronic
Input
File
Filename:
E:\
working\
Dimetheneamid\
120051c.
R98
Chemical:
Dimethenamide
RfD(
Chronic):
.05
mg/
kg
bw/
day
NOEL(
Chronic):
0
mg/
kg
bw/
day
RfD(
Acute):
.75
mg/
kg
bw/
day
NOEL(
Acute):
0
mg/
kg
bw/
day
Date
created/
last
modified:
06­
14­
2006/
15:
15:
23/
8
Program
ver.
2.03
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
EPA
Crop
Def
Res
Adj.
Factors
Comment
Code
Grp
Commodity
Name
(
ppm)
#
1
#
2
­­­­­­­­
­­­­
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­
­­­­­­
­­­­­­
­­­­­­­
95002630
O
Peanut
0.010000
1.000
1.000
95002640
O
Peanut,
butter
0.010000
1.000
1.000
95002650
O
Peanut,
oil
0.010000
1.000
1.000
86010000
O
Water,
direct,
all
sources
0.008000
1.000
1.000
86020000
O
Water,
indirect,
all
sources
0.008000
1.000
1.000
01030150
1CD
Arrowroot,
flour
0.010000
1.000
1.000
01030151
1CD
Arrowroot,
flour­
babyfood
0.010000
1.000
1.000
01030170
1CD
Artichoke,
Jerusalem
0.010000
1.000
1.000
01010500
1AB
Beet,
garden,
roots
0.010000
1.000
1.000
01010501
1AB
Beet,
garden,
roots­
babyfood
0.010000
1.000
1.000
01010520
1A
Beet,
sugar
0.010000
1.000
1.000
01010521
1A
Beet,
sugar­
babyfood
0.010000
1.000
1.000
01010530
1A
Beet,
sugar,
molasses
0.010000
1.000
1.000
01010531
1A
Beet,
sugar,
molasses­
babyfood
0.010000
1.000
1.000
01030820
1CD
Cassava
0.010000
1.000
1.000
01030821
1CD
Cassava­
babyfood
0.010000
1.000
1.000
01031390
1CD
Dasheen,
corm
0.010000
1.000
1.000
01031660
1CD
Ginger
0.010000
1.000
1.000
01031661
1CD
Ginger­
babyfood
0.010000
1.000
1.000
01031670
1CD
Ginger,
dried
0.010000
1.000
1.000
01011900
1AB
Horseradish
0.010000
1.000
1.000
01032960
1C
Potato,
chips
0.010000
1.000
1.000
01032970
1C
Potato,
dry
(
granules/
flakes)
0.010000
1.000
1.000
01032971
1C
Potato,
dry
(
granules/
flakes)­
b
0.010000
1.000
1.000
01032980
1C
Potato,
flour
0.010000
1.000
1.000
01032981
1C
Potato,
flour­
babyfood
0.010000
1.000
1.000
01032990
1C
Potato,
tuber,
w/
peel
0.010000
1.000
1.000
01032991
1C
Potato,
tuber,
w/
peel­
babyfood
0.010000
1.000
1.000
01033000
1C
Potato,
tuber,
w/
o
peel
0.010000
1.000
1.000
01033001
1C
Potato,
tuber,
w/
o
peel­
babyfood
0.010000
1.000
1.000
01033660
1CD
Sweet
potato
0.010000
1.000
1.000
01033661
1CD
Sweet
potato­
babyfood
0.010000
1.000
1.000
01033710
1CD
Tanier,
corm
0.010000
1.000
1.000
01033870
1CD
Turmeric
0.010000
1.000
1.000
01034060
1CD
Yam,
true
0.010000
1.000
1.000
01034070
1CD
Yam
bean
0.010000
1.000
1.000
02000510
2
Beet,
garden,
tops
0.010000
1.000
1.000
02001400
2
Dasheen,
leaves
0.010000
1.000
1.000
03001640
3
Garlic
0.010000
1.000
1.000
03001650
3
Garlic,
dried
0.010000
1.000
1.000
03001651
3
Garlic,
dried­
babyfood
0.010000
1.000
1.000
03001980
3
Leek
0.010000
1.000
1.000
03002370
3
Onion,
dry
bulb
0.010000
1.000
1.000
03002371
3
Onion,
dry
bulb­
babyfood
0.010000
1.000
1.000
03002380
3
Onion,
dry
bulb,
dried
0.010000
1.000
1.000
03002381
3
Onion,
dry
bulb,
dried­
babyfood
0.010000
1.000
1.000
03002390
3
Onion,
green
0.010000
1.000
1.000
03003380
3
Shallot
0.010000
1.000
1.000
06030300
6C
Bean,
black,
seed
0.010000
1.000
1.000
06030320
6C
Bean,
broad,
seed
0.010000
1.000
1.000
06030340
6C
Bean,
cowpea,
seed
0.010000
1.000
1.000
06030350
6C
Bean,
great
northern,
seed
0.010000
1.000
1.000
06030360
6C
Bean,
kidney,
seed
0.010000
1.000
1.000
06030380
6C
Bean,
lima,
seed
0.010000
1.000
1.000
06030390
6C
Bean,
mung,
seed
0.010000
1.000
1.000
06030400
6C
Bean,
navy,
seed
0.010000
1.000
1.000
06030410
6C
Bean,
pink,
seed
0.010000
1.000
1.000
06030420
6C
Bean,
pinto,
seed
0.010000
1.000
1.000
06030980
6C
Chickpea,
seed
0.010000
1.000
1.000
06030981
6C
Chickpea,
seed­
babyfood
0.010000
1.000
1.000
06030990
6C
Chickpea,
flour
0.010000
1.000
1.000
06003470
6
Soybean,
seed
0.010000
1.000
1.000
06003480
6
Soybean,
flour
0.010000
1.000
1.000
06003481
6
Soybean,
flour­
babyfood
0.010000
1.000
1.000
06003490
6
Soybean,
soy
milk
0.010000
1.000
1.000
06003491
6
Soybean,
soy
milk­
babyfood
or
in
0.010000
1.000
1.000
Dimethenamid­
p
Dietary
Exposure
Assessment
DP
Num:
318282
PC
Code:
129051
Page:
13
of
14
06003500
6
Soybean,
oil
0.010000
1.000
1.000
06003501
6
Soybean,
oil­
babyfood
0.010000
1.000
1.000
09023570
9B
Squash,
winter
0.010000
1.000
1.000
09023571
9B
Squash,
winter­
babyfood
0.010000
1.000
1.000
15001200
15
Corn,
field,
flour
0.010000
1.000
1.000
15001201
15
Corn,
field,
flour­
babyfood
0.010000
1.000
1.000
15001210
15
Corn,
field,
meal
0.010000
1.000
1.000
15001211
15
Corn,
field,
meal­
babyfood
0.010000
1.000
1.000
15001220
15
Corn,
field,
bran
0.010000
1.000
1.000
15001230
15
Corn,
field,
starch
0.010000
1.000
1.000
15001231
15
Corn,
field,
starch­
babyfood
0.010000
1.000
1.000
15001240
15
Corn,
field,
syrup
0.010000
1.000
1.000
15001241
15
Corn,
field,
syrup­
babyfood
0.010000
1.000
1.000
15001250
15
Corn,
field,
oil
0.010000
1.000
1.000
15001251
15
Corn,
field,
oil­
babyfood
0.010000
1.000
1.000
15001260
15
Corn,
pop
0.010000
1.000
1.000
15001270
15
Corn,
sweet
0.010000
1.000
1.000
15001271
15
Corn,
sweet­
babyfood
0.010000
1.000
1.000
15003440
15
Sorghum,
grain
0.010000
1.000
1.000
Dimethenamid­
p
Dietary
Exposure
Assessment
DP
Num:
318282
PC
Code:
129051
Page:
14
of
14
Attachment
4:
Chronic
Output
File
U.
S.
Environmental
Protection
Agency
Ver.
2.00
DEEM­
FCID
Chronic
analysis
for
DIMETHENAMIDE
(
1994­
98
data)
Residue
file
name:
E:\
working\
Dimetheneamid\
120051c.
R98
Adjustment
factor
#
2
NOT
used.
Analysis
Date
06­
14­
2006/
15:
19:
20
Residue
file
dated:
06­
14­
2006/
15:
16:
58/
8
Reference
dose
(
RfD,
Chronic)
=
.05
mg/
kg
bw/
day
===============================================================================
Total
exposure
by
population
subgroup
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

Total
Exposure
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
Population
mg/
kg
Percent
of
Subgroup
body
wt/
day
Rfd
­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­
­­­­­­­­­­­­­
­­­­­­­­­­­­­­­
U.
S.
Population
(
total)
0.000205
0.4%

U.
S.
Population
(
spring
season)
0.000204
0.4%
U.
S.
Population
(
summer
season)
0.000218
0.4%
U.
S.
Population
(
autumn
season)
0.000199
0.4%
U.
S.
Population
(
winter
season)
0.000199
0.4%

Northeast
region
0.000187
0.4%
Midwest
region
0.000210
0.4%
Southern
region
0.000197
0.4%
Western
region
0.000230
0.5%

Hispanics
0.000233
0.5%
Non­
hispanic
whites
0.000200
0.4%
Non­
hispanic
blacks
0.000198
0.4%
Non­
hisp/
non­
white/
non­
black
0.000242
0.5%

All
infants
(<
1
year)
0.000605
1.2%
Nursing
infants
0.000227
0.5%
Non­
nursing
infants
0.000749
1.5%
Children
1­
6
yrs
0.000314
0.6%
Children
7­
12
yrs
0.000210
0.4%

Females
13­
19
(
not
preg
or
nursing)
0.000155
0.3%
Females
20+
(
not
preg
or
nursing)
0.000193
0.4%
Females
13­
50
yrs
0.000194
0.4%
Females
13+
(
preg/
not
nursing)
0.000194
0.4%
Females
13+
(
nursing)
0.000265
0.5%

Males
13­
19
yrs
0.000170
0.3%
Males
20+
yrs
0.000181
0.4%
Seniors
55+
0.000188
0.4%

Children
1­
2
yrs
0.000329
0.7%
Children
3­
5
yrs
0.000316
0.6%
Children
6­
12
yrs
0.000221
0.4%
Youth
13­
19
yrs
0.000163
0.3%
Adults
20­
49
yrs
0.000187
0.4%
Adults
50+
yrs
0.000189
0.4%
Females
13­
49
yrs
0.000185
0.4%

­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­