Document ID: EPA-HQ-OPP-2006-0965-0005
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2007-05-09T04:00Z

SEQ CHAPTER \h \r 1 

     

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

                                                                        
                                                                        
                                            

                                                                        
                                                                        
        			      OFFICE OF     

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM

DATE:  	March 29, 2007 

SUBJECT:	Flufenacet – Revised Memorandum: Acute and Chronic Aggregate
Dietary Exposure and Risk Assessments for the Proposed Section 3
Registration on Wheat, Sweet Corn and Grass Grown for Seed.  Petition
Number: 6F04631.

PC Code:	121903			Decision Number: 303540

DP Number: 	338504

REVIEWER:	Susan L. Stanton, Environmental Scientist

Reregistration Branch 3

Health Effects Division (7509P)

THROUGH:	Thomas Bloem, Chemist

		Sheila Piper, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P)

and

Will Donovan, Chemist

Reregistration Branch 3

Health Effects Division (7509P)

TO:		Jack Arthur, Risk Assessor

		Registration Action Branch 3

Health Effects Division (7509P)

and

Tobi Colvin-Snyder

Herbicide Branch

Registration Division (7505P)

Estimates of U.S. field corn and soybean acreage presented in the
previous flufenacet dietary exposure memorandum (S. Stanton; D334695;
12/12/06) were incorrect.  They have been corrected in this document. 
The revisions do not affect the acute or chronic dietary exposure
estimates, and no other changes have been made to the document.

Executive Summary

 Model (DEEM-FCID™), Version 2.03, which uses food consumption data
from the U.S. Department of Agriculture’s Continuing Surveys of Food
Intakes by Individuals (CSFII) from 1994-1996 and 1998.  The analyses
were performed to support the proposed FIFRA sec. 3 registration of the
herbicide, flufenacet, on wheat, sweet corn and grass grown for seed.

Flufenacet is currently registered for food use under FIFRA sec. 3 on
field corn and soybean and under FIFRA sec. 18 on wheat.  Permanent and
temporary tolerances for these commodities have been established under
40 CFR sec. 180.527.  Tolerances have also been established to cover
secondary residues in livestock (cattle, goat, hog, horse and sheep) and
indirect or inadvertent residues in alfalfa, clover, cereal grains
(except rice) and grasses (forage, fodder and hay) that may occur as a
result of the registered uses (i.e., residues in rotational crops).

Partially refined, Tier 3 acute probabilistic and chronic dietary (food
+ drinking water) exposure assessments were conducted for all existing
and proposed food uses of flufenacet.  Anticipated residues for many
crops (field corn, soybean, sweet corn and wheat) were developed using
field trial data.  Anticipated residues for livestock commodities were
derived using available feeding and metabolism studies in conjunction
with the anticipated dietary burden to ruminants, swine and poultry. 
Tolerance level residues were used to assess flufenacet exposure from
the remaining commodities (i.e., cereal grains).  Acute and chronic
exposure estimates for all commodities were further refined using
percent crop treated (%CT) data, following the guidance provided in HED
SOP 99.6 (Classification of Food Forms with Respect to level of
Blending; 8/20/99).  Projected %CT data were used to refine anticipated
residues for the new food uses (sweet corn and wheat).  Available
processing data were used to refine anticipated residues for cereal
grains and corn.  For all other processed commodities, DEEM (ver. 7.81)
default processing factors were assumed.

Estimated drinking water concentrations (EDWCs) were provided by EFED
(R. Parker; DP Num: 318616, 318629; 10/04/06) and incorporated directly
into the DEEM analyses.  For the acute assessment, the entire 30-year
distribution of estimated daily surface water concentrations for the
Ohio corn crop scenario was used in a probabilistic analysis.  For the
chronic assessment, the estimated 1-in-10 year annual mean residue in
surface water was used as a point estimate in a deterministic analysis.

Acute Dietary Exposure Results

Based on the assumptions described above, estimated acute dietary
exposure is below HED’s level of concern for the U.S. population and
all population subgroups.  Combined dietary exposure from food and
drinking water at the 99.9th percentile of exposure is estimated to be
0.000514 mg/kg/day for the general U.S. population, equivalent to 30% of
the acute Population Adjusted Dose (aPAD).  The population subgroup with
the highest estimated acute dietary exposure is infants, less than 1
year old, with an estimated exposure at the 99.9th percentile of
0.001514 mg/kg/day, equivalent to 89% of the aPAD.  The major
contributor to dietary exposure for all population subgroups is drinking
water.  Estimated acute dietary exposure from food alone is less than or
equal to 13% of the aPAD for the general U.S. population and all
subgroups.

Chronic Dietary Exposure Results

Chronic dietary exposure estimates for food and drinking water combined
are well below HED’s level of concern.  Using the DEEM-FCID software,
chronic dietary exposure is estimated at 0.000049 mg/kg/day for the
general U.S. population (2.9% of the chronic Population Adjusted Dose
(cPAD)) and 0.000156 mg/kg/day (9.2% of the cPAD) for infants <1 year
old, the population subgroup with the highest estimated chronic dietary
exposure to flufenacet.  As with the acute assessment, the major
contributor to estimated chronic dietary exposure is drinking water. 
Estimated chronic dietary exposure from food alone represents less than
1% of the aPAD for the general U.S. population and all subgroups.

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to the point of departure (POD; e.g.,
NOAEL, LOAEL) divided by the appropriate uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  References which
discuss the acute and chronic risk assessments in more detail are
available on the EPA/pesticides web site:  “Available Information on
Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web
link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see
SOP 99.6 (8/20/99).

The most recent HED dietary risk assessment for flufenacet was conducted
by William D Wassell (Memo, dated 05/14/03; DP Num 289838) to support a
FIFRA §18 emergency exemption request for the use of flufenacet on
wheat.  

II.	Food Residue Information

Residues of Concern:  The nature of flufenacet residues in plants is
understood for the existing and proposed commodities, based on adequate
studies using a preplant application to corn and soybeans and a
postemergence application to corn and wheat.  The Metabolism Assessment
Review Committee (MARC) concluded in a meeting on 7/16/97 that the
residues of concern in plants for both tolerance expression and risk
assessment are parent and the metabolites containing the
4-fluoro-N-methylethyl benzenamine moiety.

The nature of the residue in livestock is also understood, based on
adequate goat and poultry metabolism studies using 14C-labeled parent
and plant metabolites.  The metabolism of flufenacet and its plant
metabolites is similar in ruminants and poultry.  Based on the results
of these studies, the MARC (DP Num: 241928, N. Dodd, 12/18/97) concluded
that the residues of concern in ruminants and poultry for the tolerance
expression are parent and the metabolites containing the
4-fluoro-N-methylethyl benzenamine moiety.  The dietary risk assessment
for livestock commodities should also include thiadone related residues,
glycoside conjugate (THNG) and the malonylalanine conjugate of thiadone.

The MARC also concluded at its 7/16/97 meeting that thiadone residues
should be included, along with parent flufenacet, in the drinking water
risk assessment.  

Tolerances:  Permanent tolerances have been established for flufenacet
and its metabolites containing the 4-fluoro-N-methylethyl benzenamine
moiety in/on raw agricultural commodities [field corn forage (0.4 ppm),
grain (0.05 ppm), and stover (0.4 ppm); and soybean seed (0.1 ppm)]
under 40 CFR §180.527(a); and at 0.1 ppm for indirect or inadvertent
residues in/on alfalfa and clover; cereal grains (crop group 15), except
rice; and forage, fodder and straw of cereal grains  (crop group 16),
except rice; and the forage, fodder and hay of grass (crop group 17)
under 40 CFR 180.527(d).  In addition, time-limited tolerances have been
established in connection with Section 18 emergency exemption under 40
CFR 180.527(b) for livestock commodities at 0.05 ppm in fat and meat of
cattle, goats, hogs, horses, and sheep; 0.10 ppm in meat byproducts
except kidney of cattle, goats, hogs, horses, and sheep; and 0.50 ppm in
kidney of cattle, goats, hogs, horses, and sheep and for wheat forage
(10 ppm), grain (1.0 ppm), hay (2.0 ppm) and straw (0.50 ppm).  These
time-limited tolerances are set to expire on 6/30/07.  No tolerances
have been established for milk, eggs or poultry commodities.

Based on its review of data submitted with the current petition,
including additional residue data to support a revised use pattern for
field corn, HED has determined that tolerances for flufenacet and its
metabolites should be revised as shown in Table 1 (A. Acierto; 11/29/06;
DP Num: 288564 & 288565).  Where appropriate, the tolerance levels were
determined using the Tolerance/MRL Harmonization Spreadsheet.

Table 1.  Recommended Tolerances for Flufenacet

Commodity	Recommended Tolerance (ppm)

§180.527(a).   Tolerances for the combined residues of the Herbicide,
N-(4-fluorophenyl)-N-(1-methylethyl)-2-[[5-(trifluoromethyl)-1,3,4-thiad
iazol-2-yl]oxy]acetamide and its metabolites containing the
4-fluoro-N-methylethyl benzenamine moiety.

Corn, field, forage 	0.45

Corn, field, grain	0.05

Corn, field, stover	0.30

Corn, sweet, forage 	0.45

Corn, sweet, kernel plus cob with husks removed	0.05

Corn, sweet, stover	0.30

Soybean, seed1	0.05

Wheat, bran	0.80

Wheat, forage	6.0

Wheat, grain	0.60

Wheat, hay	1.2

Wheat, straw	0.35

Cattle, kidney	0.05

Goat, kidney	0.05

Hog kidney	0.05

Horse, kidney	0.05

Sheep, kidney	0.05

40CFR 180.527(c).
N-(4-fluorophenyl)-N-(1-methylethyl)-2-[[5-(trifluoromethyl)-1,3,4-thiad
iazol-2-yl]oxy]acetamide and its metabolites containing the
4-fluoro-N-methylethyl benzenamine moiety, with regional registration.

Grass, forage	7.0

Grass, hay	0.4

40CFR 180.527(d).
N-(4-fluorophenyl)-N-(1-methylethyl)-2-[[5-(trifluoromethyl)-1,3,4-thiad
iazol-2-yl]oxy]acetamide and its metabolites containing the
4-fluoro-N-methylethyl benzenamine moiety for indirect or inadvertent
residues

Alfalfa, forage	2.0

Alfalfa, hay	2.0

Alfalfa, seed	0.10

Clover, forage 	2.0

Clover, hay	2.0

Cereal, grain, crop group 15, except rice	0.10

Cereal, grain, forage, fodder, and straw, crop group 16, except rice 	

2.0

Grass, forage, fodder and hay, crop group 17	2.0

1 The available soybean data support the established tolerance of 0.10
ppm for soybean seeds.  However, in light of the proposed reduced
application rate (0.45 lb ai/A instead of 0.9 lb ai/A) and the European
tolerance level of 0.05 ppm, HED now recommends that the soybean, seed
tolerance be lowered to 0.05 ppm.

Residue Data used for the Acute and Chronic Assessments:  

Food:  Refined, Tier 3 acute probabilistic and chronic dietary exposure
assessments were conducted for all existing and proposed new food uses
of flufenacet and drinking water.  Anticipated residues for many crops
(field corn, soybean, sweet corn and wheat) were developed using field
trial data.  Anticipated residues for livestock commodities were derived
using available feeding and metabolism studies in conjunction with the
anticipated dietary burden to ruminants, swine and poultry.  Tolerance
level residues were used to assess flufenacet exposure from the
remaining commodities (i.e., cereal grains).  Pesticide Data Program
(PDP) monitoring data are available for wheat flour (2003,2004), wheat
grain (2005) and pork fat/muscle (2005).  The PDP data were not used to
develop anticipated residues for wheat commodities, since they reflect
the historical, regional section 18 use of flufenacet on wheat in the
Pacific Northwest, rather than the proposed section 3 national use. 
Since wheat makes up 80% of the theoretical swine diet, the PDP data for
pork commodities are also considered inappropriate for estimating
anticipated residues in these commodities.

Acute and chronic exposure estimates for all commodities were further
refined using %CT data, following the guidance provided in HED SOP 99.6
(Classification of Food Forms with Respect to level of Blending;
8/20/99).  Projected %CT data were used to refine anticipated residues
for the new food uses (sweet corn and wheat).  Available processing data
were used to refine anticipated residues for cereal grains and corn. 
For all other processed commodities, DEEM (ver. 7.81) default processing
factors were assumed.

Anticipated residues for plant commodities were calculated in accordance
with HED guidance for Tier 3 assessments as follows:

Acute Assessment:

Field corn, soybean and wheat (blended commodities):  Average field
trial residues were calculated and multiplied by the maximum %CT or
projected %CT (wheat) estimate in the acute DEEM analysis.  A residue
value equal to ½ the Limit of Quantitation (LOQ) was assumed for all
field trial samples with non-detectable residues.

Other cereal grains (blended commodities):  Flufenacet is not registered
for direct application to these crops; however, inadvertent residues may
occur in these crops from flufenacet’s use on other crops.  In the
DEEM analysis, the tolerance level of 0.1 ppm for inadvertent residues
was multiplied by the maximum projected %CT estimate for wheat (the
field crop with the highest estimated or projected maximum %CT).

Sweet corn (not blended or partially blended):  All sweet corn field
trial samples contained non-detectable residues of flufenacet.  For the
acute assessment, a residue distribution file was constructed using ½
the LOQ for non-detectable residues and incorporating zeros to account
for the percent of the crop not likely to be treated with flufenacet.

Chronic Assessment:

Field corn, soybean, wheat (blended commodities) and sweet corn (not
blended or partially blended):  Average field trial residues were
calculated and multiplied by the average %CT or projected %CT (wheat)
estimate in the chronic DEEM analysis.  A residue value  equal to ½ the
Limit of Quantitation (LOQ) was assumed for all field trial samples with
non-detectable residues.

Other cereal grains (blended commodities):  Flufenacet is not registered
for direct application to these crops; however, inadvertent residues may
occur in these crops from flufenacet’s use on other crops.  In the
DEEM analysis, the tolerance level of 0.1 ppm for inadvertent residues
was multiplied by the average projected %CT estimate for wheat (the
field crop with the highest estimated or projected average %CT).

The residue data for plant commodities used in the chronic and acute
dietary assessments are summarized in Table 2.  Residue distribution
files (RDFs) used in the acute assessment are included in the
attachments.



Table 2.  Data and Residue Estimates Used in Dietary Analyses

RAC	Food

Forms	Classification1	Data

Source	No. of

Samples	No. of

Detectable

Residues	LOQ

(ppm)	%CT	Processing

Factors	Anticipated Residue Estimates/Tolerance

	Ave.	Max.

Acute (Tol., AR, RDF)5	Chronic (Tol., AR)

Cereal Grains (Barley, Buckwheat, Millet, Oat, Popcorn, Rye, Sorghum)
All	B	Tolerance	N/A	N/A	N/A	12	32	Flour: 0.44x3

Bran: 2.1x3

	0.1 ppm adjusted by 3%CT	0.1 ppm adjusted by  1%CT

Corn, field	All	B	Ave. Field Trial; MRID: 45012405 & 45012407	62	0	0.05
<14	<2.54	All: 1x5	0.025 ppm adjusted by 2.5%CT	0.025 ppm adjusted by
1%CT

Corn, sweet	All	NB/PB	Field Trial; MRID: 45012405 & 45012407	18	0	0.05
36	106	N/A	RDF:

'Sweet Corn, using maximum projected 10%CT

TOTALZ=90

TOTALLOD=10

LODRES=0.025	0.025 ppm adjusted by 3%CT

Soybean	All	B	Ave. Field Trial: MRID: 43850093	22	2	0.05	<14	<2.54	1x5
0.03 ppm adjusted by 2.5%CT	0.03 ppm adjusted by 1%CT

Wheat/Triticale	All	B	Ave. Field Trial: MRID: 45012401	38	38 (29 above
LOQ)	0.05	16	36	Flour: 0.44x3

Bran: 2.1x3

	0.13 ppm adjusted by 3%CT	0.13 ppm adjusted by 1%CT

1.	Classification of blended (B), partially blended (PB), not blended
(NB).

2.	Based on projected %CT for wheat, the field crop with the highest
estimated ave. and max. %CT.

3.	Based on processing data for wheat: MRID#45012408; A. Acierto; DP
Num: 288564; 07/27/06.

4.	Screening Level Usage Analysis; BEAD; 08/18/2005

5.	N. Dodd; DP Num: 224142: 12/12/96

6.	Projected Percent Crop Treated for Herbicide Flufenacet (PC 121903)
on Sweet Corn, Wheat and Grasses Grown for Seed; N. Zinn & A Grube; DP
Nums: 320497, 321194; 10/25/2006



Anticipated residues for livestock commodities were calculated as
described in the following sections.  As mentioned above, the residues
of concern for risk assessment in livestock include parent flufenacet
plus thiadone related residues, glycoside conjugate (THNG) and the
malonylalanine conjugate of thiadone.  So, while tolerances are only
required for a few animal commodities (kidney of cattle, goat, hog,
horse and sheep), anticipated residues for flufenacet and thiadone
compounds have been calculated for all livestock commodities, including
ruminants, swine and poultry.

The DEEM input values calculated for ruminants, swine and poultry were
incorporated into the acute and chronic analyses as follows:

The calculated anticipated residues for livestock were used
probabilistically in the acute assessment following the procedures
outlined in the 4/6/99 e-mail from David Miller to Novigen.  These
procedures were subsequently summarized and posted on the Dietary
Exposure Scientific Advisory Committee (DE SAC) database by Christina
Swartz (10/14/99).  Residue distribution files (RDFs) were constructed
using the calculated anticipated residue value for the percentage of the
livestock commodity expected to contain residues and zeros for the
percentage of the commodity expected to be residue-free.  The percentage
of the commodity expected to contain residues was assumed to equal to
the highest maximum %CT estimate for any single feed item.  For
ruminants, swine and poultry, the feed item with the highest %CT
estimate is wheat (3% projected).  Therefore, RDFs were constructed for
each livestock commodity with a 3% probability of encountering the
calculated anticipated residue and a 97% probability of encountering a
zero. 

The calculated anticipated residues for livestock were used
deterministically in the chronic assessment.  The point estimates were
adjusted by the highest average %CT estimate.  Again, the highest
average %CT estimate for any single feed item is wheat (1% projected). 
Therefore, 1% was incorporated as an adjustment factor for each
livestock commodity in the chronic DEEM analysis.

Note:  BEAD’s maximum and average projected %CT estimates for sweet
corn are 10% and 3%, respectively, which are higher than the estimates
for wheat used to refine the exposure estimates for livestock
commodities in the acute and chronic analyses.  Sweet corn was not
included in the proposed livestock diets and the projected %CT estimates
were not used to adjust exposures for livestock commodities, because the
sweet corn acreage is small compared to the acreage planted to corn,
soybeans and wheat.  Over the last 5 years, less than 1 million acres of
sweet corn have been planted in the U.S., compared to approximately 60
million acres of wheat, 75 million acres of soybeans and 80 million
acres of field corn (from USDA’s National Agricultural Statistics
Service website).

Cattle, goats, horses, and sheep:

To determine anticipated residues for cattle, goat, sheep and horse
tissues, the dietary burden to these livestock was determined using the
proposed diet developed by J. Stokes and B. Schneider (DP Num:332410;
09/13/06). Table 3 summarizes the dietary burden for beef and dairy
cattle.  

Table 3.  Anticipated Flufenacet Residues in the Diet of Dairy1 and Beef
Cattle

Feed Item	

AR2

(ppm)	

% Dry Matter	

%  Diet--Dairy Cattle	

%  Diet–

Beef Cattle	

Diary Cattle Residue (ppm)	

Beef Cattle Residue (ppm)

Field Corn  Forage	

0.36	

40	

20	

15	0.18	0.135

Field Corn Stover	

0.15	

83	

10	

--	

0.018	

--

Field Corn Grain	

0.025	

88	

35	

30	0.01	0.0085

Wheat, Milled Byproducts	0.13

(grain)3	88	10	20	0.015	0.03

Wheat, Hay	0.95	88	10	20	0.108	0.216

Soybean Meal	

0.03

(seed)	

92	

15	

15	

0.005	

0.005

Anticipated Dietary Burden (ppm)	0.34	0.39

1Flufenacet is also proposed for use on grass grown for seed in the
Pacific Northwest and sweet corn, both of which may be fed to cattle. 
However, these crops were not included in the proposed diet because of
the limited acreage compared to the acreage planted to field corn, wheat
and soybeans.

2ARs for forage, hay and stover (Non-blended feed items) are the HAFT
value from the crop field trials while the ARs for field corn grain,
wheat milled byproducts and soybean meal (Blended feed items) are the
average residue levels from the field trials.

3Processing data (MRID 45012408) indicate that residues do not
concentrate in milled byproducts (shorts, middlings, AGF).

A 29-day dairy cattle feeding study was conducted using FOE oxalate
(MRID 43850090).  This metabolite was used because it was a major plant
metabolite, whereas no parent flufenacet was found in plant metabolism
studies.  The cattle feeding study was reviewed and found acceptable
(Memo, 1/7/97, N. Dodd, DP Num:224142).  Milk samples from the 82.4 and
24.67 ppm groups from various treatment days were analyzed for residues
of FOE oxalate.  Residue levels in all milk samples were <0.01 ppm.  The
results of this study are summarized in Table 4. 

.

Table 4.  Maximum FOE Oxalate Residues from the Cattle Feeding Study

Treatment Level (ppm)*	

Kidney (ppm)	

Liver (ppm)	

Fat (ppm)	

Muscle (ppm) 	

Milk (ppm) 

82.4	

0.64	

0.19	

0.10	

0.09	

<0.01

24.7	

0.32	

0.057	

<0.05	

<0.05	

<0.01

7.80	

0.058	

<0.05	

Not analyzed	

Not analyzed	

Not analyzed

The results of the feeding study corrected for the rate of exaggeration
(based on the anticipated dietary burdens for beef and dairy cattle) are
summarized in Table 5.

  

Table 5.  Corrected FOE Oxalate Residues from the Cattle Feeding Study

Treatment Level (ppm)*	

Kidney (ppm)	

Liver (ppm)	

Fat (ppm)	

Muscle (ppm) 	

Milk (ppm) 

82.4 (211x/242x)	

0.003	

0.0009	

0.0005	

0.0004	

0.00002

24.7 (63/73x)	

0.005	

0.0009	

0.0004	

0.0004	

0.00007

7.80 (20/23x)	

0.003	

0.0013	

Not analyzed	

Not analyzed	

Not analyzed

Average	

0.0037	

0.001	

0.00045	

0.0004	

0.000045

* In parenthesis are the exaggeration rates based on the anticipated DB
of 0.39 ppm for beef cattle/0.34 ppm for dairy cattle.

A metabolism study using 166 ppm [thiadiazole-2-14C] flufenacet was
conducted on a lactating goat.  This dose rate corresponds to an
exaggerated rate of 426x the anticipated dietary burden calculated for
beef cattle and 488x for diary cattle.  The results of this metabolism
study are discussed in HED’s review of 6/30/97 (Memo, N. Dodd, DP Num:
236252) and are summarized in Table 6.  

Table 6.  Derivation of DEEM Input Values for Livestock Commodities of
Cattle, Goat, Horse, and Sheep.   

Matrix	

Residue	

% TRR	

ppm (426x/488x)	

ppm

(1x1)	

Flufenacet2 AnticipatedResidue (AR) Level ppm	

DEEM3 input ppm

fat	

thiadone	

89	

2.533	

0.006	

0.00045	

0.0064

kidney	

thiadone glucuronide

thiadone	

9

89	

1.837

18.164	

0.0043

0.0426	

0.0037	

0.051

liver	

thiadone glucuronide

thiadone	

5

86	

0.848

14.582	

0.002

0.034	

0.001	

0.037

muscle	

thiadone	

84	

3.205	

0.0075	

0.0004	

0.0079

milk- avg4	

thiadone glucuronide

thiadone	

10

40	

0.054

0.23	

0.00011

0.00047	

0.000045	

0.00062

1  Normalized to 1X rate based on anticipated dietary burden for beef
cattle (fat, kidney, liver and muscle) or dairy cattle (milk).

2  From Table 5.

3  Sum of [thiadone + thiadone glucuronide] + flufenacet AR.

4  Values for milk in the above table are averaged over the 3-day study.

Thus, for the dietary risk assessment, anticipated residue values for
livestock commodities represent a sum of the anticipated-residue level
selected for flufenacet and metabolites containing the 
4-fluoro-N-methylethyl benzenamine moiety added to the calculated level
of thiadone-related compounds based on the anticipated dietary burden. 
The appropriate residue level for meat byproducts and other organ meats
is that of kidney, as this anticipated residue level is considered the
worst-case value for all tissues.

Swine:

In order to determine ARs for swine tissues, the dietary burden to swine
was determined using a reasonable diet (A. Acierto; 11/29/06; DP Num:
288564 & 288565) and anticipated (average field trial) residues for the
feed items.  Table 7 summarizes the anticipated dietary burden for
swine.  

Table 7.  Anticipated Flufenacet Dietary Burden for Swine

Feed Item	

AR (ppm)	

% in Diet–Swine	

Possible Residue (ppm)

Wheat grain	

0.13	

80	0.104

Soybean meal	

0.03	

20	0.006

Anticipated Dietary Burden for Swine	0.110

Table 7 shows that the anticipated swine dietary burden for flufenacet
is 0.11 ppm.  ARs for swine were determined in a way similar to that for
ruminants, using the cattle feeding and goat metabolism studies, as
described below.  The corrected results of the cattle feeding study
based on the anticipated swine dietary burden are summarized in Table 8.

  

Table 8.  Corrected FOE Oxalate Residues from the Cattle Feeding Study

Treatment Level (ppm)*	

Kidney (ppm)	

Liver (ppm)	

Fat (ppm)	

Muscle (ppm) 

82.4 (749x)	0.00085	0.00025	0.00013	0.00012

24.7 (224x)	0.0014	0.00025	0.00011	0.00011

7.80 (71x)	0.00082	0.00035	

Not analyzed	

Not analyzed

Average	0.0010	0.00028	0.00012	0.00012

* In parenthesis is the exaggeration rate based on the anticipated DB of
0.11 ppm for swine. 

The goat metabolism study was conducted using a dose of 166 ppm
[thiadiazole-2-14C] flufenacet, which corresponds to an exaggerated rate
of 1509x the anticipated DB calculated for swine.  The results of this
metabolism study are discussed in HED’s review of 6/30/97 (Memo, N.
Dodd, DP Num: 236252) and summarized below in Table 9.

Table 9.  Derivation of DEEM Input Values for Livestock Commodities of
Swine. 

Matrix	

Residue	

% TRR	

ppm (1509x)	

ppm

(1x1)	

Flufenacet2 Residue Level ppm	

DEEM3 input ppm

fat	

thiadone	

89	

2.533	0.0017	0.00012	0.0018

kidney	

thiadone glucuronide

thiadone	

9

89	

1.837

18.164	0.0012

0.012	0.0010	0.014

liver	

thiadone glucuronide

thiadone	

5

86	

0.848

14.582	0.00056

0.0097	0.00028	0.011

muscle	

thiadone	

84	

3.205	0.0022	0.00012	0.0023

1  Normalized to 1X rate based on the anticipated swine dietary burden.

2  From Table 8.

3  Sum of [thiadone + thiadone glucuronide] + flufenacet AR.

Thus, for the dietary risk assessment, residue values for pork
commodities represent a sum of the anticipated residue level of
flufenacet and metabolites containing the  4-fluoro-N-methylethyl
benzenamine moiety added to the calculated level of thiadone-related
compounds based on the anticipated swine dietary burden.  The
appropriate residue level for meat byproducts and other organ meats is
that of kidney, as this anticipated residue value is considered the
worst-case value for all tissues.  For DEEM commodities designated as
“skin” such as “Pork, skin”, the anticipated residue level for
fat was used.

Poultry:

In order to determine ARs for poultry tissues, the dietary burden to
poultry was determined using a reasonable diet (A. Acierto; 11/29/06; DP
Num: 288564 & 288565) and anticipated (average field trial) residues for
the feed items.  Table 10 summarizes the anticipated dietary burden for
poultry.  

Table 10.  Anticipated Flufenacet Dietary Burden for Poultry.

Feed Item	

AR (ppm)	

% in Diet–Poultry	

Possible Residue (ppm)

Wheat grain	

0.13	

80	

0.104

Soybean meal	0.03	20	0.006

Anticipated Dietary Burden for Poultry	

0.11

Table 10 shows that the anticipated poultry dietary burden of flufenacet
from treated feed items is 0.11 ppm.  No flufenacet poultry feeding
study is available for review.  However, poultry metabolism studies
using [thiadiazole-2-14C] flufenacet (MRID 43850076),
[fluorophenyl-UL-14C] flufenacet (MRID 43850074), and
[fluorophenyl-UL-14C] FOE oxalate (MRID 438500798)  at 78 ppm are
available.  Collectively, these studies show that no tolerances are
needed for flufenacet and its metabolites containing the
4-fluoro-N-methylethyl benzenamine moiety in poultry commodities.  But,
as with the ruminants, thiadone-related residues predominate.  The hen
metabolism study using [thiadiazole-2-14C] flufenacet at 78 ppm
(corresponding to an exaggeration rate of 709x the anticipated DB) gave
results for thiadone-related residues as discussed in the HED memo of
6/30/97 (Memo, N. Dodd, DP Num: 236252) and as summarized in Table 11. 

Table 11.  Derivation of DEEM Input Values for Poultry Commodities

Matrix	

Metabolite	

% TRR	

ppm (flufenacet equivalents)	

DEEM input ppm

	

1000x	

1x1

	

fat	

thiadone	80	

1.430	0.0020	0.0020

liver	thiadone glucuronide

thiadone	

9

83	0.935

8.620	0.0013

0.012	0.013

muscle	

thiadone	

86	1.920	0.0027	0.0027

Eggs - avg2	

thiadone	

90	0.408	0.00058	0.00058

1  Normalized to 1X rate based on the anticipated DB to poultry.  

2  Values for eggs in the above table are averaged over the 3 days of
the study.

Thus, for the dietary risk assessment, anticipated residue values for
poultry commodities represent the calculated level of thiadone-related
compounds based on the anticipated dietary burden.  The appropriate
residue level for meat byproducts and other organ meats is that of
liver, as this is considered the worst-case value for all tissues.  For
DEEM commodities designated as “skin”, such as “chicken, skin”
or “poultry, other, skin”, the anticipated residue level for fat was
used.

 Drinking Water Data

Reference:  Revised Estimated Drinking Water Concentrations of
Flufenacet and Degradate Thiadone for the Use in Human Health Risk
Assessment; Ronald Parker; DP Num: 318616, 318629; 10/04/06.

The residues of concern in drinking water include flufenacet and its
degradate, thiadone.  The Environmental Fate and Effects Division (EFED)
provided estimated drinking water concentrations (EDWCs) of flufenacet
and thiadone in surface water using the Tier II PRZM/EXAMS models.
Groundwater EDWCs were provided for parent flufenacet only using the
Tier I SCIGROW model.  

Ground Water:  For ground water, the acute and chronic flufenacet EDWC
from the SCIGROW model is 0.10 ppb.  Ground-water monitoring information
provided by the registrant supports the SCIGROW model result as a
reasonable estimate of groundwater concentrations.  Acute and chronic
concentrations of 0.18 ppb and 0.03 ppb, respectively, were seen in a
small-scale prospective groundwater study conducted by the registrant in
a Nebraska aquifer that could reasonably be expected to be used for
drinking water. (FOE 5043; Reregistration Eligibility Document;
October,1997). The Agency has been unable to locate any other field
monitoring data for flufenacet in groundwater.

Surface Water:  For surface water, the combined one-in-ten-year peak
(acute) and one-in-ten-year mean (chronic) estimated concentrations of
flufenacet and thiadone are presented in Table 12 for two Midwest corn
belt cropping scenarios (Ohio corn and Illinois corn).  Thiadone
concentrations are expected to average 11 percent of parent flufenacet
concentrations at the time of year when combined concentrations are the
highest.  Therefore, combined concentrations of flufenacet and thiadone
were derived by multiplying parent flufenacet concentrations by a factor
of 1.11.

Table 12. Combined Acute and Chronic Surface Water Concentrations for
Parent Chemical Flufenacet Plus Degradate Thiadone.

PRZM Scenario	 Acute Parent Flufenacet (ppb)	 Chronic Parent Flufenacet
(ppb)	Acute Degradate Thiadone (ppb)	Chronic Degradate Thiadone (ppb)
Sum: Acute Parent Plus Degradate (ppb)	Sum: Chronic Parent Plus
Degradate (ppb)

Ohio Corn	7.78	2.01	0.86	0.22	8.64	2.23

Illinois Corn	9.07	2.55	1.00	0.28	10.07	2.83

Of all the labeled crops, the highest surface water concentrations would
be expected for corn and soybeans, because the application rate is
higher and there is more area planted to these crops; and surface water
EDWCs for these two crops should not be different. The Ohio and Illinois
corn scenarios were chosen as the most appropriate national-level
scenarios based on their location in the Midwestern corn belt.  The
modeling results for these two scenarios are similar, with the Illinois
scenario returning only slightly higher values.  This slight difference
is not due to differences in soil vulnerability in Ohio and Illinois;
rather, it is an artifact of planting date selection relative to
rainfall events at these two locations.  EFED selected application dates
14 days before recommended planting dates without regard to rainfall
dates for the two scenarios.  Since growers seek to maximize the benefit
of pesticide applications, they would be expected to apply flufenacet
when dry weather is forecast.  Therefore, the model results for the Ohio
corn scenario were selected as appropriate for use in the dietary
assessment.  The selection of the Ohio scenario also provides
consistency with the previous 2003 dietary assessment which used
drinking water estimates based on the Ohio corn scenario.

The estimated surface water concentrations of flufenacet are nearly 2
orders of magnitude higher than estimated groundwater concentrations. 
Therefore, the PRZM/EXAMS surface water modeling results were used in
the dietary assessment.   For the acute assessment, the entire 30-year
distribution of estimated daily concentrations from the Ohio corn
scenario was used in a probabilistic analysis.  For the chronic
assessment, the estimated 1-in-10 year annual mean residue was used as a
point estimate in a deterministic analysis.

IV.	DEEM-FCID™ Program and Consumption Information

Flufenacet acute and chronic dietary exposure assessments were conducted
using the Dietary Exposure Evaluation Model software with the Food
Commodity Intake Database (DEEM-FCID™, Version 2.03), which
incorporates consumption data from USDA’s Continuing Surveys of Food
Intakes by Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98
data are based on the reported consumption of more than 20,000
individuals over two non-consecutive survey days.  Foods “as
consumed” (e.g., apple pie) are linked to EPA-defined food commodities
(e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicly available recipe
translation files developed jointly by USDA/ARS and EPA.  For chronic
exposure assessment, consumption data are averaged for the entire U.S.
population and within population subgroups, but for acute exposure
assessment are retained as individual consumption events.  Based on
analysis of the 1994-96, 98 CSFII consumption data, which took into
account dietary patterns and survey respondents, HED concluded that it
is most appropriate to report risk for the following population
subgroups: the general U.S. population, all infants (<1 year old),
children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49,
females 13-49, and adults 50+ years old.

For chronic dietary exposure assessments, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., only those who reported
eating relevant commodities/food forms) and a per-capita (i.e., those
who reported eating the relevant commodities as well as those who did
not) basis.  In accordance with HED policy, per capita exposure and risk
are reported for all tiers of analysis.  However, for Tiers 1 and 2, any
significant differences in user vs. per capita exposure and risk are
specifically identified and noted in the risk assessment.

V.	Toxicological Information

On April 23, 2003, the HED Hazard Identification Assessment Review
Committee (HIARC) reviewed the recommendations of the toxicology
reviewer for flufenacet with regard to the appropriate toxicological
endpoints and doses for human health risk assessments. The potential for
increased susceptibility of infants and children from exposure to
flufenacet was also evaluated as required by the Food Quality Protection
Act (FQPA) of 1996.  The doses and toxicological endpoints selected for
the various dietary exposure scenarios are summarized in Table 13.

Table 13.  Summary of Dietary Endpoints and Doses Selected for
Flufenacet2

Exposure

Scenario	

Dose (mg/kg/day) 

Uncertainty Factor (UF)	

Special FQPA SF* and Level of Concern for Risk Assessment	

Study and Endpoint

for Dietary Risk Assessment

Acute Dietary

(all populations)

	

LOAEL = 1.7 mg/kg/day

UF = 1000X1

Acute RfD =

0.0017 mg/kg/day	

FQPA SF = 1X

aPAD = 0.0017  mg/kg/day	

Developmental-neurotoxicity study in rats

LOAEL = 1.7  mg/kg/day, based on decreased body weight/body weight gain
and missing morphometric measurements in caudate/putamen in pups.

Chronic Dietary

(all populations)	

LOAEL= 1.7 mg/kg/day

UF = 1000X1

Chronic RfD = 

0.0017 mg/kg/day

	

FQPA SF = 1X

cPAD = 0.0017 mg/kg/day	

Developmental-neurotoxicity study in rats

LOAEL = 1.7  mg/kg/day, based on decreased body weight/body weight gain
in pups.

Cancer Classification	

E (Not likely to be a Human Carcinogen)

1The 1000-fold uncertainty factor includes 10X interspecies, 10X
intraspecies and 10X for the lack of a NOAEL in the DNT and the
requirement of a comparative thyroid study.

2UF = uncertainty factor, FQPA SF = Special FQPA safety factor, NOAEL =
no-observed-adverse-effect-level, LOAEL =
lowest-observed-adverse-effect-level, PAD = population adjusted dose (a
= acute, c = chronic) RfD = reference dose.

VI.	Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned
when dietary risk exceeds 100% of the PAD.  The DEEM-FCID™ analyses
estimate the dietary exposure of the U.S. population and various
population subgroups.  The acute and chronic results reported below are
for the general U.S. Population, all infants (<1 year old), children
1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults
20-49, and adults 50+ years.  

Results of Acute Dietary Exposure Analysis

Based on the assumptions described above, estimated acute dietary
exposure is below HED’s level of concern for the U.S. population and
all population subgroups.  Combined dietary exposure from food and
drinking water at the 99.9th percentile of exposure is estimated to be
0.000514 mg/kg/day for the general U.S. population, equivalent to 30% of
the acute Population Adjusted Dose (aPAD).  The population subgroup with
the highest estimated acute dietary exposure is infants, less than 1
year old, with an estimated exposure at the 99.9th percentile of
0.001514 mg/kg/day, equivalent to 89% of the aPAD.  The acute dietary
exposure results at the 99.9th percentile are compared to the results at
the 95th and 99th percentiles in Table 14.

Table 14.  Results of Acute Dietary (Food + Drinking Water) Exposure
Analysis Using DEEM FCID 

Population Subgroup	aPAD (mg/kg/day)	95th Percentile	99th Percentile
99.9th Percentile

Exposure (mg/kg/day)	% aPAD	Exposure (mg/kg/day)	% aPAD	Exposure
(mg/kg/day)	% aPAD

General U.S. Population	0.0017	0.000115	6.8	0.000230	14	0.000514	30

All Infants (< 1 year old)

0.000396	23	0.000790	46	0.001514	89

Children 1-2 years old

0.000185	11	0.000361	21	0.000720	42

Children 3-5 years old

0.000171	10	0.000325	19	0.000635	37

Children 6-12 years old

0.000118	7.0	0.000227	13	0.000444	26

Youth 13-19 years old

0.000088	5.2	0.000178	10	0.000389	23

Adults 20-49 years old

0.000105	6.2	0.000206	12	0.000424	25

Adults 50+ years old

0.000104	6.1	0.000190	11	0.000344	20

Females 13-49 years old

0.000106	6.2	0.000207	12	0.000418	25

The major contributor to dietary exposure for all population subgroups
is drinking water.  Estimated acute dietary exposure from food alone is
less than or equal to 13% of the aPAD for the general U.S. population
and all subgroups.  Estimated acute exposures (99.9th percentile) from
food alone and drinking water alone are compared to exposures for food
and water combined in Table 15, below.  Please note that the analyses
for food, drinking water, and food + drinking water were conducted
separately and that the results are not additive (i.e., food exposure +
drinking water exposure ≠ the combined exposure for food and drinking
water).

Table 15.  Results of Acute Dietary Exposure Analysis for Food, Drinking
Water and Combined Food and Drinking Water at the 99.9th Percentile of
Exposure

Population Subgroup	aPAD (mg/kg/day)	Food Alone	Drinking Water Alone
Food and Drinking Water

Exposure (mg/kg/day)	% aPAD	Exposure (mg/kg/day)	% aPAD	Exposure
(mg/kg/day)	% aPAD

General U.S. Population	0.0017	0.000102	6.0	0.000503	30	0.000514	30

All Infants (< 1 year old)

0.000110	6.4	0.001520	89	0.001514	89

Children 1-2 years old

0.000215	13	0.000690	41	0.000720	42

Children 3-5 years old

0.000223	13	0.000611	36	0.000635	37

Children 6-12 years old

0.000148	8.7	0.000428	25	0.000444	26

Youth 13-19 years old

0.000085	5.0	0.000377	22	0.000389	23

Adults 20-49 years old

0.000069	4.1	0.000419	25	0.000424	25

Adults 50+ years old

0.000063	3.7	0.000339	20	0.000344	20

Females 13-49 years old

0.000073	4.3	0.000413	24	0.000418	25

Results of Chronic Dietary Exposure Analysis

Chronic dietary exposure estimates for food and drinking water combined
are well below HED’s level of concern.  Using the DEEM-FCID software,
chronic dietary exposure is estimated at 0.000049 mg/kg/day for the
general U.S. population (2.9% of the chronic Population Adjusted Dose
(cPAD)) and 0.000156 mg/kg/day (9.2% of the cPAD) for infants <1 year
old, the population subgroup with the highest estimated chronic dietary
exposure to flufenacet.  As with the acute assessment, the major
contributor to estimated chronic dietary exposure is drinking water. 
Estimated chronic dietary exposure from food alone represents less than
1% of the aPAD for the general U.S. population and all subgroups. 
Estimated chronic exposures from food alone and drinking water alone are
compared to exposures for food and water combined in Table 16, below.

Table 16.  Summary of Chronic Dietary Exposure and Risk for Flufenacet1

Population Subgroup	Food Only	Drinking Water Only	Total

	 Exposure

(mg/kg/day)	% cPAD	 Exposure

(mg/kg/day)	% cPAD	 Exposure

(mg/kg/day)	% cPAD

	cPAD = 0.0017 mg/kg/day

General U.S. Population	0.000002	<1	0.000047	2.8	0.000049	2.9

All Infants (< 1 year old)	0.000002	<1	0.000154	9.1	0.000156	9.2

Children 1-2 years old	0.000005	<1	0.000070	4.1	0.000075	4.4

Children 3-5 years old	0.000005	<1	0.000065	3.8	0.000070	4.1

Children 6-12 years old	0.000003	<1	0.000045	2.7	0.000048	2.9

Youth 13-19 years old	0.000002	<1	0.000034	2.0	0.000036	2.1

Adults 20-49 years old	0.000002	<1	0.000044	2.6	0.000046	2.7

Adults 50+ years old	0.000001	<1	0.000046	2.7	0.000048	2.8

Females 13-49 years old	0.000002	<1	0.000044	2.6	0.000045	2.7

1The population subgroup with the highest estimated chronic dietary
(food + drinking water) exposure and risk is indicated by bold text.

VII.	Characterization of Inputs/Outputs

Both the acute and chronic dietary analyses may be considered partially
refined.  A characterization of the inputs/outputs and uncertainties
regarding the assessment is provided below.

Food:

The assessment for food incorporates anticipated residue estimates for
most crops and livestock commodities that were derived using field trial
data.  Although field trial data provide more refined exposure estimates
than tolerances, the results may still be considered somewhat
conservative, since field trials are conducted under maximum use
conditions (maximum allowed application rate, minimum PHI, etc.).  In
actual practice, flufenacet is likely to be applied using a range of
rates and PHIs, and treated commodities may be stored for various time
periods (beyond the minimum PHI) prior to consumption by humans or
livestock.

Anticipated residues for food commodities were adjusted for %CT, using
screening level usage estimates for the existing crops (field corn and
soybeans) and projected %CT estimates for new uses (sweet corn and
wheat), both of which are intended to provide “protective” exposure
estimates.

Drinking Water:

Drinking water is the risk “driver” in both the acute and chronic
dietary analyses.  PRZM-EXAMS surface water modeling data were used
probabilistically in the acute analysis and deterministically in the
chronic analysis.  The modeling estimates were partially refined in that
they took into consideration crop-specific percent cropped area (PCA). 
PRZM/EXAMS data represent the range of concentrations that are estimated
to result from the annual use of flufenacet over a 30 year period at the
maximum application rate.  Although the PRZM/EXAMS models provide more
refined estimates of surface water residues than the Tier 1 FIRST model,
the drinking water inputs may be considered conservative, since they
assume that applications will be made at maximum application rates to
the entire crop within the watershed every year for 30 years.

The PRZM/EXAMS results for the Ohio corn scenario were used in this
assessment and in the previous 2003 dietary assessment for flufenacet. 
Although the Illinois corn scenario returned a slightly higher 1-in-10
year peak concentration in EFED’s current analysis, the difference is
so small (10 ppb vs. 8.6 ppb) that it would not be expected to
significantly impact the risk assessment results.  The results for the
Ohio corn scenario are considered to provide a reasonable, high-end
estimate of drinking water exposure to residues of flufenacet.

VIII.	Conclusions

 exposure analyses using DEEM-FCID™  indicate that acute and chronic
dietary exposures to flufenacet from food and drinking water are below
HED’s level of concern for this pesticide for the general U.S.
population and all population subgroups.

IX.		List of Attachments

RDF Files Used in the Acute Dietary Analyses

Acute Food Only Input File

Acute Food Only Results File

Acute Drinking Water Only Input File

Acute Drinking Water Only Results File

Acute Food + Drinking Water Input File

Acute Food + Drinking Water Results File

Chronic Food Only Input File

Chronic Food Only Results File

Chronic Drinking Water Only Input File

Chronic Drinking Water Only Results File

Chronic Food + Drinking Water Input File

Chronic Food + Drinking Water Results File

RDF Files Used in the Acute Dietary Analyses

1.

'meat

TOTALNZ=3

TOTALZ=97

0.0079

0.0079

0.0079

	2.

'meatfat

TOTALNZ=3

TOTALZ=97

0.0064

0.0064

0.0064

	3.

'meatbyproducts

TOTALNZ=3

TOTALZ=97

0.051

0.051

0.051

4.

'meatliver

TOTALNZ=3

TOTALZ=97

0.037

0.037

0.037

	5.

'pork meat

TOTALNZ=3

TOTALZ=97

0.0023

0.0023

0.0023	6.

'porkfat

TOTALNZ=3

TOTALZ=97

0.0018

0.0018

0.0018

7.

'pork kidney

TOTALNZ=3

TOTALZ=97

0.014

0.014

0.014

	8.

'pork liver

TOTALNZ=3

TOTALZ=97

0.011

0.011

0.011

	9.

'poultry meat

TOTALNZ=3

TOTALZ=97

0.0027

0.0027

0.0027

10.

'poultry fat

TOTALNZ=3

TOTALZ=97

0.0020

0.0020

0.0020

	11.

'poultry liver

TOTALNZ=3

TOTALZ=97

0.013

0.013

0.013

	12.

'eggs

TOTALNZ=3

TOTALZ=97

0.00058

0.00058

0.00058

13. (Only the first few daily concentration values from the drinking
water distribution of more than 10,000 daily values are shown)

'OH Corn Flufenacet + Thiadone

'Parent * 1.11 with 0.46 PCA factor

1.33E-03

1.33E-03

1.32E-03

1.32E-03

1.31E-03

1.31E-03

1.30E-03

1.30E-03

1.30E-03

1.29E-03

1.29E-03

1.28E-03

1.28E-03

1.27E-03

1.27E-03

....

	14.

'milk

TOTALNZ=3

TOTALZ=97

0.00062

0.00062

0.00062

	15.

'Sweet Corn, using maximum projected 10%CT

TOTALZ=90

TOTALLOD=10

LODRES=0.025

Acute Food Only Input File

U.S. Environmental Protection Agency                                
Ver. 2.02

DEEM-FCID Acute analysis for FLUFENACET

Residue file name: C:\Documents and Settings\sstanton\My
Documents\DEEM-FCID Files\Flufenacet\Flufenacet Acute\Flufenacet Acute
Food Only.R98

Analysis Date 12-05-2006             Residue file dated:
12-05-2006/13:14:18/8

Reference dose: aRfD = 0.0017 mg/kg bw/day  NOEL = 1.7 mg/kg bw/day

Comment: Flufenacet Acute - Food Only

------------------------------------------------------------------------
--------

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1           Param #2    Param #3    Comment

  #   Code 

----- ---- ------------           ----------- ----------- ----------

  1    6   Meat.rdf

  2    6   Meat Fat.rdf

  3    6   Meat Byproducts.rdf

  4    6   Meat Liver.rdf

  5    6   Pork Meat.RDF

  6    6   Pork Fat.rdf

  7    6   Pork Kidney.RDF

  8    6   Pork Liver.RDF

  9    6   Poultry Meat.RDF

  10   6   Poultry Fat.RDF

  11   6   Poultry Liver.RDF

  12   6   Eggs.RDF

  13   6   OH Corn Flufenacet + Thiadone.RDF

  14   6   Milk.rdf

  15   6   Sweet Corn.RDF

  EPA    Crop Food Name                         Def Res     Adj.Factors 
RDL  Comment

  Code    Grp                                    (ppm)       #1     #2  
Pntr

-------- ---- -------------------------------  ----------  ------ ------
---  -------

15000250 15   Barley, pearled barley             0.100000   1.000  0.030
     

15000251 15   Barley, pearled barley-babyfood    0.100000   1.000  0.030
     

15000260 15   Barley, flour                      0.100000   0.440  0.030
     

15000261 15   Barley, flour-babyfood             0.100000   0.440  0.030
     

15000270 15   Barley, bran                       0.100000   2.100  0.030
     

21000440 M    Beef, meat                         1.000000   1.000  1.000
  1  

21000441 M    Beef, meat-babyfood                1.000000   1.000  1.000
  1  

21000450 M    Beef, meat, dried                  1.000000   1.920  1.000
  1  

21000460 M    Beef, meat byproducts              1.000000   1.000  1.000
  3  

21000461 M    Beef, meat byproducts-babyfood     1.000000   1.000  1.000
  3  

21000470 M    Beef, fat                          1.000000   1.000  1.000
  2  

21000471 M    Beef,fat-babyfood                  1.000000   1.000  1.000
  2  

21000480 M    Beef, kidney                       1.000000   1.000  1.000
  3  

21000490 M    Beef, liver                        1.000000   1.000  1.000
  4  

21000491 M    Beef, liver-babyfood               1.000000   1.000  1.000
  4  

15000650 15   Buckwheat                          0.100000   1.000  0.030
     

15000660 15   Buckwheat, flour                   0.100000   0.440  0.030
     

40000930 P    Chicken, meat                      1.000000   1.000  1.000
  9  

40000931 P    Chicken, meat-babyfood             1.000000   1.000  1.000
  9  

40000940 P    Chicken, liver                     1.000000   1.000  1.000
 11  

40000950 P    Chicken, meat byproducts           1.000000   1.000  1.000
 11  

40000951 P    Chicken, meat byproducts-babyfoo   1.000000   1.000  1.000
 11  

40000960 P    Chicken, fat                       1.000000   1.000  1.000
 10  

40000961 P    Chicken, fat-babyfood              1.000000   1.000  1.000
 10  

40000970 P    Chicken, skin                      1.000000   1.000  1.000
 10  

40000971 P    Chicken, skin-babyfood             1.000000   1.000  1.000
 10  

15001200 15   Corn, field, flour                 0.025000   1.000  0.025
     

15001201 15   Corn, field, flour-babyfood        0.025000   1.000  0.025
     

15001210 15   Corn, field, meal                  0.025000   1.000  0.025
     

15001211 15   Corn, field, meal-babyfood         0.025000   1.000  0.025
     

15001220 15   Corn, field, bran                  0.025000   1.000  0.025
     

15001230 15   Corn, field, starch                0.025000   1.000  0.025
     

15001231 15   Corn, field, starch-babyfood       0.025000   1.000  0.025
     

15001240 15   Corn, field, syrup                 0.025000   1.000  0.025
     

15001241 15   Corn, field, syrup-babyfood        0.025000   1.000  0.025
     

15001250 15   Corn, field, oil                   0.025000   1.000  0.025
     

15001251 15   Corn, field, oil-babyfood          0.025000   1.000  0.025
     

15001260 15   Corn, pop                          0.100000   1.000  0.030
     

15001270 15   Corn, sweet                        1.000000   1.000  1.000
 15  

15001271 15   Corn, sweet-babyfood               1.000000   1.000  1.000
 15  

70001450 P    Egg, whole                         1.000000   1.000  1.000
 12  

70001451 P    Egg, whole-babyfood                1.000000   1.000  1.000
 12  

70001460 P    Egg, white                         1.000000   1.000  1.000
 12  

70001461 P    Egg, white (solids)-babyfood       1.000000   1.000  1.000
 12  

70001470 P    Egg, yolk                          1.000000   1.000  1.000
 12  

70001471 P    Egg, yolk-babyfood                 1.000000   1.000  1.000
 12  

23001690 M    Goat, meat                         1.000000   1.000  1.000
  1  

23001700 M    Goat, meat byproducts              1.000000   1.000  1.000
  3  

23001710 M    Goat, fat                          1.000000   1.000  1.000
  2  

23001720 M    Goat, kidney                       1.000000   1.000  1.000
  3  

23001730 M    Goat, liver                        1.000000   1.000  1.000
  4  

24001890 M    Horse, meat                        1.000000   1.000  1.000
  1  

27002220 D    Milk, fat                          1.000000   1.000  1.000
 14  

27002221 D    Milk, fat - baby food/infant for   1.000000   1.000  1.000
 14  

27012230 D    Milk, nonfat solids                1.000000   1.000  1.000
 14  

27012231 D    Milk, nonfat solids-baby food/in   1.000000   1.000  1.000
 14  

27022240 D    Milk, water                        1.000000   1.000  1.000
 14  

27022241 D    Milk, water-babyfood/infant form   1.000000   1.000  1.000
 14  

27032251 D    Milk, sugar (lactose)-baby food/   1.000000   1.000  1.000
 14  

15002260 15   Millet, grain                      0.100000   1.000  0.030
     

15002310 15   Oat, bran                          0.100000   2.100  0.030
     

15002320 15   Oat, flour                         0.100000   0.440  0.030
     

15002321 15   Oat, flour-babyfood                0.100000   0.440  0.030
     

15002330 15   Oat, groats/rolled oats            0.100000   1.000  0.030
     

15002331 15   Oat, groats/rolled oats-babyfood   0.100000   1.000  0.030
     

25002900 M    Pork, meat                         1.000000   1.000  1.000
  5  

25002901 M    Pork, meat-babyfood                1.000000   1.000  1.000
  5  

25002910 M    Pork, skin                         1.000000   1.000  1.000
  6  

25002920 M    Pork, meat byproducts              1.000000   1.000  1.000
  7  

25002921 M    Pork, meat byproducts-babyfood     1.000000   1.000  1.000
  7  

25002930 M    Pork, fat                          1.000000   1.000  1.000
  6  

25002931 M    Pork, fat-babyfood                 1.000000   1.000  1.000
  6  

25002940 M    Pork, kidney                       1.000000   1.000  1.000
  7  

25002950 M    Pork, liver                        1.000000   1.000  1.000
  8  

60003010 P    Poultry, other, meat               1.000000   1.000  1.000
  9  

60003020 P    Poultry, other, liver              1.000000   1.000  1.000
 11  

60003030 P    Poultry, other, meat byproducts    1.000000   1.000  1.000
 11  

60003040 P    Poultry, other, fat                1.000000   1.000  1.000
 10  

60003050 P    Poultry, other, skin               1.000000   1.000  1.000
 10  

15003280 15   Rye, grain                         0.100000   1.000  0.030
     

15003290 15   Rye, flour                         0.100000   0.440  0.030
     

26003390 M    Sheep, meat                        1.000000   1.000  1.000
  1  

26003391 M    Sheep, meat-babyfood               1.000000   1.000  1.000
  1  

26003400 M    Sheep, meat byproducts             1.000000   1.000  1.000
  3  

26003410 M    Sheep, fat                         1.000000   1.000  1.000
  2  

26003411 M    Sheep, fat-babyfood                1.000000   1.000  1.000
  2  

26003420 M    Sheep, kidney                      1.000000   1.000  1.000
  3  

26003430 M    Sheep, liver                       1.000000   1.000  1.000
  4  

15003440 15   Sorghum, grain                     0.100000   1.000  0.030
     

15003450 15   Sorghum, syrup                     0.100000   1.000  0.030
     

06003470 6    Soybean, seed                      0.030000   1.000  0.025
     

06003480 6    Soybean, flour                     0.030000   1.000  0.025
     

06003481 6    Soybean, flour-babyfood            0.030000   1.000  0.025
     

06003490 6    Soybean, soy milk                  0.030000   1.000  0.025
     

06003491 6    Soybean, soy milk-babyfood or in   0.030000   1.000  0.025
     

06003500 6    Soybean, oil                       0.030000   1.000  0.025
     

06003501 6    Soybean, oil-babyfood              0.030000   1.000  0.025
     

15003810 15   Triticale, flour                   0.130000   0.440  0.030
     

15003811 15   Triticale, flour-babyfood          0.130000   0.440  0.030
     

50003820 P    Turkey, meat                       1.000000   1.000  1.000
  9  

50003821 P    Turkey, meat-babyfood              1.000000   1.000  1.000
  9  

50003830 P    Turkey, liver                      1.000000   1.000  1.000
 11  

50003831 P    Turkey, liver-babyfood             1.000000   1.000  1.000
 11  

50003840 P    Turkey, meat byproducts            1.000000   1.000  1.000
 11  

50003841 P    Turkey, meat byproducts-babyfood   1.000000   1.000  1.000
 11  

50003850 P    Turkey, fat                        1.000000   1.000  1.000
 10  

50003851 P    Turkey, fat-babyfood               1.000000   1.000  1.000
 10  

50003860 P    Turkey, skin                       1.000000   1.000  1.000
 10  

50003861 P    Turkey, skin-babyfood              1.000000   1.000  1.000
 10  

15004010 15   Wheat, grain                       0.130000   1.000  0.030
     

15004011 15   Wheat, grain-babyfood              0.130000   1.000  0.030
     

15004020 15   Wheat, flour                       0.130000   0.440  0.030
     

15004021 15   Wheat, flour-babyfood              0.130000   0.440  0.030
     

15004030 15   Wheat, germ                        0.130000   1.000  0.030
     

15004040 15   Wheat, bran                        0.130000   2.100  0.030
     

Acute Food Only Results File

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for FLUFENACET                         
(1994-98 data)

Residue file: Flufenacet Acute Food Only.R98          Adjustment factor
#2 used.

Analysis Date: 12-05-2006/13:35:31    Residue file dated:
12-05-2006/13:14:18/8

NOEL (Acute) =   1.700000 mg/kg body-wt/day

Daily totals for food and foodform consumption used.

MC iterations = 1000      MC list in residue file     MC seed = 100

Run Comment: "Flufenacet Acute - Food Only"

========================================================================
=======

Summary calculations (per capita):

      95th Percentile             99th Percentile             99.9th
Percentile

 Exposure  % aRfD     MOE    Exposure  % aRfD     MOE    Exposure  %
aRfD     MOE  

---------- ------- -------- ---------- ------- -------- ----------
------- --------

U.S. Population:

  0.000016    0.94  106267    0.000033    1.93   51860    0.000102   
6.00   16680  

All infants:

  0.000017    1.00  100121    0.000030    1.76   56925    0.000110   
6.45   15512  

Children 1-2 yrs:

  0.000034    1.97   50689    0.000075    4.39   22766    0.000215  
12.63    7914  

Children 3-5 yrs:

  0.000030    1.74   57387    0.000065    3.83   26111    0.000223  
13.11    7626  

Children 6-12 yrs:

  0.000021    1.23   81312    0.000046    2.71   36957    0.000148   
8.70   11490  

Youth 13-19 yrs:

  0.000013    0.78  128730    0.000026    1.54   65046    0.000085   
5.01   19965  

Adults 20-49 yrs:

  0.000011    0.66  152634    0.000023    1.34   74620    0.000069   
4.06   24655  

Adults 50+ yrs:

  0.000009    0.53  188236    0.000019    1.10   90738    0.000063   
3.70   27061  

Females 13-49 yrs:

  0.000011    0.62  161747    0.000021    1.22   81894    0.000073   
4.31   23222  



Acute Drinking Water Only Input File

U.S. Environmental Protection Agency                                
Ver. 2.02

DEEM-FCID Acute analysis for FLUFENACET

Residue file name: C:\Documents and Settings\sstanton\My
Documents\DEEM-FCID Files\Flufenacet\Flufenacet Acute\Flufenacet Acute
DW only_OH Corn Scenario.R98

Analysis Date 11-24-2006             Residue file dated:
11-01-2006/08:06:36/8

Reference dose (aRfD) = 0.0017 mg/kg bw/day

Comment: Drinking Water Only using PRZM-EXAMS Distribution for OH Corn
Scenario

------------------------------------------------------------------------
--------

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1           Param #2    Param #3    Comment

  #   Code 

----- ---- ------------           ----------- ----------- ----------

  1    6   OH Corn Flufenacet + Thiadone.RDF

  EPA    Crop Food Name                         Def Res     Adj.Factors 
RDL  Comment

  Code    Grp                                    (ppm)       #1     #2  
Pntr

-------- ---- -------------------------------  ----------  ------ ------
---  -------

86010000 O    Water, direct, all sources         1.000000   1.000  1.000
  1  

86020000 O    Water, indirect, all sources       1.000000   1.000  1.000
  1  

Acute Drinking Water Only Results File

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for FLUFENACET                         
(1994-98 data)

Residue file: Flufenacet Acute DW only_OH Corn Scenario.R98

    Adjustment factor #2 used.

Analysis Date: 11-24-2006/09:08:46    Residue file dated:
11-01-2006/08:06:36/8

Daily totals for food and foodform consumption used.

MC iterations = 1000      MC list in residue file     MC seed = 100

Run Comment: "Drinking Water Only using PRZM-EXAMS Distribution for OH
Corn Sc

enario"

========================================================================
=======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
--------

U.S. Population:

                    0.000106     6.26    0.000220    12.95    0.000503  
 29.61 

All infants:

                    0.000392    23.04    0.000785    46.17    0.001520  
 89.41 

Children 1-2 yrs:

                    0.000164     9.62    0.000335    19.72    0.000690  
 40.60 

Children 3-5 yrs:

                    0.000150     8.82    0.000302    17.78    0.000611  
 35.95 

Children 6-12 yrs:

                    0.000104     6.10    0.000211    12.39    0.000428  
 25.18 

Youth 13-19 yrs:

                    0.000080     4.72    0.000171    10.04    0.000377  
 22.18 

Adults 20-49 yrs:

                    0.000099     5.85    0.000200    11.77    0.000419  
 24.64 

Adults 50+ yrs:

                    0.000099     5.84    0.000185    10.85    0.000339  
 19.93 

Females 13-49 yrs:

                    0.000100     5.87    0.000201    11.84    0.000413  
 24.29 

Acute Food + Drinking Water Input File

U.S. Environmental Protection Agency                                
Ver. 2.02

DEEM-FCID Acute analysis for FLUFENACET

Residue file name: C:\Documents and Settings\sstanton\My
Documents\DEEM-FCID Files\Flufenacet\Flufenacet Acute\Flufenacet Acute
Food + Water OH Corn Scenario.R98

Analysis Date 12-05-2006             Residue file dated:
12-05-2006/13:10:39/8

Reference dose: aRfD = 0.0017 mg/kg bw/day  NOEL = 1.7 mg/kg bw/day

Comment: Flufenacet Acute - Food + Drinking Water - OH Corn Scenario

------------------------------------------------------------------------
--------

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1           Param #2    Param #3    Comment

  #   Code 

----- ---- ------------           ----------- ----------- ----------

  1    6   Meat.rdf

  2    6   Meat Fat.rdf

  3    6   Meat Byproducts.rdf

  4    6   Meat Liver.rdf

  5    6   Pork Meat.RDF

  6    6   Pork Fat.rdf

  7    6   Pork Kidney.RDF

  8    6   Pork Liver.RDF

  9    6   Poultry Meat.RDF

  10   6   Poultry Fat.RDF

  11   6   Poultry Liver.RDF

  12   6   Eggs.RDF

  13   6   OH Corn Flufenacet + Thiadone.RDF

  14   6   Milk.rdf

  15   6   Sweet Corn.RDF

  EPA    Crop Food Name                         Def Res     Adj.Factors 
RDL  Comment

  Code    Grp                                    (ppm)       #1     #2  
Pntr

-------- ---- -------------------------------  ----------  ------ ------
---  -------

15000250 15   Barley, pearled barley             0.100000   1.000  0.030
     

15000251 15   Barley, pearled barley-babyfood    0.100000   1.000  0.030
     

15000260 15   Barley, flour                      0.100000   0.440  0.030
     

15000261 15   Barley, flour-babyfood             0.100000   0.440  0.030
     

15000270 15   Barley, bran                       0.100000   2.100  0.030
     

21000440 M    Beef, meat                         1.000000   1.000  1.000
  1  

21000441 M    Beef, meat-babyfood                1.000000   1.000  1.000
  1  

21000450 M    Beef, meat, dried                  1.000000   1.920  1.000
  1  

21000460 M    Beef, meat byproducts              1.000000   1.000  1.000
  3  

21000461 M    Beef, meat byproducts-babyfood     1.000000   1.000  1.000
  3  

21000470 M    Beef, fat                          1.000000   1.000  1.000
  2  

21000471 M    Beef,fat-babyfood                  1.000000   1.000  1.000
  2  

21000480 M    Beef, kidney                       1.000000   1.000  1.000
  3  

21000490 M    Beef, liver                        1.000000   1.000  1.000
  4  

21000491 M    Beef, liver-babyfood               1.000000   1.000  1.000
  4  

15000650 15   Buckwheat                          0.100000   1.000  0.030
     

15000660 15   Buckwheat, flour                   0.100000   0.440  0.030
     

40000930 P    Chicken, meat                      1.000000   1.000  1.000
  9  

40000931 P    Chicken, meat-babyfood             1.000000   1.000  1.000
  9  

40000940 P    Chicken, liver                     1.000000   1.000  1.000
 11  

40000950 P    Chicken, meat byproducts           1.000000   1.000  1.000
 11  

40000951 P    Chicken, meat byproducts-babyfoo   1.000000   1.000  1.000
 11  

40000960 P    Chicken, fat                       1.000000   1.000  1.000
 10  

40000961 P    Chicken, fat-babyfood              1.000000   1.000  1.000
 10  

40000970 P    Chicken, skin                      1.000000   1.000  1.000
 10  

40000971 P    Chicken, skin-babyfood             1.000000   1.000  1.000
 10  

15001200 15   Corn, field, flour                 0.025000   1.000  0.025
     

15001201 15   Corn, field, flour-babyfood        0.025000   1.000  0.025
     

15001210 15   Corn, field, meal                  0.025000   1.000  0.025
     

15001211 15   Corn, field, meal-babyfood         0.025000   1.000  0.025
     

15001220 15   Corn, field, bran                  0.025000   1.000  0.025
     

15001230 15   Corn, field, starch                0.025000   1.000  0.025
     

15001231 15   Corn, field, starch-babyfood       0.025000   1.000  0.025
     

15001240 15   Corn, field, syrup                 0.025000   1.000  0.025
     

15001241 15   Corn, field, syrup-babyfood        0.025000   1.000  0.025
     

15001250 15   Corn, field, oil                   0.025000   1.000  0.025
     

15001251 15   Corn, field, oil-babyfood          0.025000   1.000  0.025
     

15001260 15   Corn, pop                          0.100000   1.000  0.030
     

15001270 15   Corn, sweet                        1.000000   1.000  1.000
 15  

15001271 15   Corn, sweet-babyfood               1.000000   1.000  1.000
 15  

70001450 P    Egg, whole                         1.000000   1.000  1.000
 12  

70001451 P    Egg, whole-babyfood                1.000000   1.000  1.000
 12  

70001460 P    Egg, white                         1.000000   1.000  1.000
 12  

70001461 P    Egg, white (solids)-babyfood       1.000000   1.000  1.000
 12  

70001470 P    Egg, yolk                          1.000000   1.000  1.000
 12  

70001471 P    Egg, yolk-babyfood                 1.000000   1.000  1.000
 12  

23001690 M    Goat, meat                         1.000000   1.000  1.000
  1  

23001700 M    Goat, meat byproducts              1.000000   1.000  1.000
  3  

23001710 M    Goat, fat                          1.000000   1.000  1.000
  2  

23001720 M    Goat, kidney                       1.000000   1.000  1.000
  3  

23001730 M    Goat, liver                        1.000000   1.000  1.000
  4  

24001890 M    Horse, meat                        1.000000   1.000  1.000
  1  

27002220 D    Milk, fat                          1.000000   1.000  1.000
 14  

27002221 D    Milk, fat - baby food/infant for   1.000000   1.000  1.000
 14  

27012230 D    Milk, nonfat solids                1.000000   1.000  1.000
 14  

27012231 D    Milk, nonfat solids-baby food/in   1.000000   1.000  1.000
 14  

27022240 D    Milk, water                        1.000000   1.000  1.000
 14  

27022241 D    Milk, water-babyfood/infant form   1.000000   1.000  1.000
 14  

27032251 D    Milk, sugar (lactose)-baby food/   1.000000   1.000  1.000
 14  

15002260 15   Millet, grain                      0.100000   1.000  0.030
     

15002310 15   Oat, bran                          0.100000   2.100  0.030
     

15002320 15   Oat, flour                         0.100000   0.440  0.030
     

15002321 15   Oat, flour-babyfood                0.100000   0.440  0.030
     

15002330 15   Oat, groats/rolled oats            0.100000   1.000  0.030
     

15002331 15   Oat, groats/rolled oats-babyfood   0.100000   1.000  0.030
     

25002900 M    Pork, meat                         1.000000   1.000  1.000
  5  

25002901 M    Pork, meat-babyfood                1.000000   1.000  1.000
  5  

25002910 M    Pork, skin                         1.000000   1.000  1.000
  6  

25002920 M    Pork, meat byproducts              1.000000   1.000  1.000
  7  

25002921 M    Pork, meat byproducts-babyfood     1.000000   1.000  1.000
  7  

25002930 M    Pork, fat                          1.000000   1.000  1.000
  6  

25002931 M    Pork, fat-babyfood                 1.000000   1.000  1.000
  6  

25002940 M    Pork, kidney                       1.000000   1.000  1.000
  7  

25002950 M    Pork, liver                        1.000000   1.000  1.000
  8  

60003010 P    Poultry, other, meat               1.000000   1.000  1.000
  9  

60003020 P    Poultry, other, liver              1.000000   1.000  1.000
 11  

60003030 P    Poultry, other, meat byproducts    1.000000   1.000  1.000
 11  

60003040 P    Poultry, other, fat                1.000000   1.000  1.000
 10  

60003050 P    Poultry, other, skin               1.000000   1.000  1.000
 10  

15003280 15   Rye, grain                         0.100000   1.000  0.030
     

15003290 15   Rye, flour                         0.100000   0.440  0.030
     

26003390 M    Sheep, meat                        1.000000   1.000  1.000
  1  

26003391 M    Sheep, meat-babyfood               1.000000   1.000  1.000
  1  

26003400 M    Sheep, meat byproducts             1.000000   1.000  1.000
  3  

26003410 M    Sheep, fat                         1.000000   1.000  1.000
  2  

26003411 M    Sheep, fat-babyfood                1.000000   1.000  1.000
  2  

26003420 M    Sheep, kidney                      1.000000   1.000  1.000
  3  

26003430 M    Sheep, liver                       1.000000   1.000  1.000
  4  

15003440 15   Sorghum, grain                     0.100000   1.000  0.030
     

15003450 15   Sorghum, syrup                     0.100000   1.000  0.030
     

06003470 6    Soybean, seed                      0.030000   1.000  0.025
     

06003480 6    Soybean, flour                     0.030000   1.000  0.025
     

06003481 6    Soybean, flour-babyfood            0.030000   1.000  0.025
     

06003490 6    Soybean, soy milk                  0.030000   1.000  0.025
     

06003491 6    Soybean, soy milk-babyfood or in   0.030000   1.000  0.025
     

06003500 6    Soybean, oil                       0.030000   1.000  0.025
     

06003501 6    Soybean, oil-babyfood              0.030000   1.000  0.025
     

15003810 15   Triticale, flour                   0.130000   0.440  0.030
     

15003811 15   Triticale, flour-babyfood          0.130000   0.440  0.030
     

50003820 P    Turkey, meat                       1.000000   1.000  1.000
  9  

50003821 P    Turkey, meat-babyfood              1.000000   1.000  1.000
  9  

50003830 P    Turkey, liver                      1.000000   1.000  1.000
 11  

50003831 P    Turkey, liver-babyfood             1.000000   1.000  1.000
 11  

50003840 P    Turkey, meat byproducts            1.000000   1.000  1.000
 11  

50003841 P    Turkey, meat byproducts-babyfood   1.000000   1.000  1.000
 11  

50003850 P    Turkey, fat                        1.000000   1.000  1.000
 10  

50003851 P    Turkey, fat-babyfood               1.000000   1.000  1.000
 10  

50003860 P    Turkey, skin                       1.000000   1.000  1.000
 10  

50003861 P    Turkey, skin-babyfood              1.000000   1.000  1.000
 10  

86010000 O    Water, direct, all sources         1.000000   1.000  1.000
 13  

86020000 O    Water, indirect, all sources       1.000000   1.000  1.000
 13  

15004010 15   Wheat, grain                       0.130000   1.000  0.030
     

15004011 15   Wheat, grain-babyfood              0.130000   1.000  0.030
     

15004020 15   Wheat, flour                       0.130000   0.440  0.030
     

15004021 15   Wheat, flour-babyfood              0.130000   0.440  0.030
     

15004030 15   Wheat, germ                        0.130000   1.000  0.030
     

15004040 15   Wheat, bran                        0.130000   2.100  0.030
     

Acute Food + Drinking Water Results File

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for FLUFENACET                         
(1994-98 data)

Residue file: Flufenacet Acute Food + Water OH Corn Scenario.R98

    Adjustment factor #2 used.

Analysis Date: 12-05-2006/13:53:11    Residue file dated:
12-05-2006/13:10:39/8

NOEL (Acute) =   1.700000 mg/kg body-wt/day

Daily totals for food and foodform consumption used.

MC iterations = 1000      MC list in residue file     MC seed = 100

Run Comment: "Flufenacet Acute - Food + Drinking Water - OH Corn
Scenario"

========================================================================
=======

Summary calculations (per capita):

      95th Percentile             99th Percentile             99.9th
Percentile

 Exposure  % aRfD     MOE    Exposure  % aRfD     MOE    Exposure  %
aRfD     MOE  

---------- ------- -------- ---------- ------- -------- ----------
------- --------

U.S. Population:

  0.000115    6.76   14793    0.000230   13.54    7387    0.000514  
30.24    3307  

All infants:

  0.000396   23.32    4288    0.000790   46.45    2152    0.001514  
89.05    1123  

Children 1-2 yrs:

  0.000185   10.90    9173    0.000361   21.26    4703    0.000720  
42.36    2360  

Children 3-5 yrs:

  0.000171   10.07    9932    0.000325   19.14    5224    0.000635  
37.33    2678  

Children 6-12 yrs:

  0.000118    6.95   14393    0.000227   13.35    7490    0.000444  
26.12    3828  

Youth 13-19 yrs:

  0.000088    5.20   19223    0.000178   10.47    9551    0.000389  
22.88    4370  

Adults 20-49 yrs:

  0.000105    6.19   16151    0.000206   12.13    8246    0.000424  
24.97    4005  

Adults 50+ yrs:

  0.000104    6.13   16319    0.000190   11.16    8964    0.000344  
20.25    4939  

Females 13-49 yrs:

  0.000106    6.21   16108    0.000207   12.15    8230    0.000418  
24.58    4068  



Chronic Food Only Input File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for FLUFENACET                        
1994-98 data

Residue file: C:\Documents and Settings\sstanton\My Documents\DEEM-FCID
Files\Flufenacet\Flufenacet Chronic\Flufenacet Chronic Food Only.R98

                                                               Adjust.
#2 used

Analysis Date 11-24-2006             Residue file dated:
11-24-2006/08:29:32/8

Reference dose (RfD) = 0.0017 mg/kg bw/day

Comment:Flufenacet Chronic - Food Only

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

15000250 15   Barley, pearled barley             0.100000   1.000     
0.010   

15000251 15   Barley, pearled barley-babyfood    0.100000   1.000     
0.010   

15000260 15   Barley, flour                      0.100000   0.440     
0.010   

15000261 15   Barley, flour-babyfood             0.100000   0.440     
0.010   

15000270 15   Barley, bran                       0.100000   2.100     
0.010   

21000440 M    Beef, meat                         0.007900   1.000     
0.010   

21000441 M    Beef, meat-babyfood                0.007900   1.000     
0.010   

21000450 M    Beef, meat, dried                  0.007900   1.920     
0.010   

21000460 M    Beef, meat byproducts              0.051000   1.000     
0.010   

21000461 M    Beef, meat byproducts-babyfood     0.051000   1.000     
0.010   

21000470 M    Beef, fat                          0.006400   1.000     
0.010   

21000471 M    Beef,fat-babyfood                  0.006400   1.000     
0.010   

21000480 M    Beef, kidney                       0.051000   1.000     
0.010   

21000490 M    Beef, liver                        0.037000   1.000     
0.010   

21000491 M    Beef, liver-babyfood               0.037000   1.000     
0.010   

15000650 15   Buckwheat                          0.100000   1.000     
0.010   

15000660 15   Buckwheat, flour                   0.100000   0.440     
0.010   

40000930 P    Chicken, meat                      0.002700   1.000     
0.010   

40000931 P    Chicken, meat-babyfood             0.002700   1.000     
0.010   

40000940 P    Chicken, liver                     0.013000   1.000     
0.010   

40000950 P    Chicken, meat byproducts           0.013000   1.000     
0.010   

40000951 P    Chicken, meat byproducts-babyfoo   0.013000   1.000     
0.010   

40000960 P    Chicken, fat                       0.002000   1.000     
0.010   

40000961 P    Chicken, fat-babyfood              0.002000   1.000     
0.010   

40000970 P    Chicken, skin                      0.002000   1.000     
0.010   

40000971 P    Chicken, skin-babyfood             0.002000   1.000     
0.010   

15001200 15   Corn, field, flour                 0.025000   1.000     
0.010   

15001201 15   Corn, field, flour-babyfood        0.025000   1.000     
0.010   

15001210 15   Corn, field, meal                  0.025000   1.000     
0.010   

15001211 15   Corn, field, meal-babyfood         0.025000   1.000     
0.010   

15001220 15   Corn, field, bran                  0.025000   1.000     
0.010   

15001230 15   Corn, field, starch                0.025000   1.000     
0.010   

15001231 15   Corn, field, starch-babyfood       0.025000   1.000     
0.010   

15001240 15   Corn, field, syrup                 0.025000   1.000     
0.010   

15001241 15   Corn, field, syrup-babyfood        0.025000   1.000     
0.010   

15001250 15   Corn, field, oil                   0.025000   1.000     
0.010   

15001251 15   Corn, field, oil-babyfood          0.025000   1.000     
0.010   

15001260 15   Corn, pop                          0.100000   1.000     
0.010   

15001270 15   Corn, sweet                        0.025000   1.000     
0.030   

15001271 15   Corn, sweet-babyfood               0.025000   1.000     
0.030   

70001450 P    Egg, whole                         0.000580   1.000     
0.010   

70001451 P    Egg, whole-babyfood                0.000580   1.000     
0.010   

70001460 P    Egg, white                         0.000580   1.000     
0.010   

70001461 P    Egg, white (solids)-babyfood       0.000580   1.000     
0.010   

70001470 P    Egg, yolk                          0.000580   1.000     
0.010   

70001471 P    Egg, yolk-babyfood                 0.000580   1.000     
0.010   

23001690 M    Goat, meat                         0.007900   1.000     
0.010   

23001700 M    Goat, meat byproducts              0.051000   1.000     
0.010   

23001710 M    Goat, fat                          0.006400   1.000     
0.010   

23001720 M    Goat, kidney                       0.051000   1.000     
0.010   

23001730 M    Goat, liver                        0.037000   1.000     
0.010   

24001890 M    Horse, meat                        0.007900   1.000     
0.010   

27002220 D    Milk, fat                          0.000620   1.000     
0.010   

27002221 D    Milk, fat - baby food/infant for   0.000620   1.000     
0.010   

27012230 D    Milk, nonfat solids                0.000620   1.000     
0.010   

27012231 D    Milk, nonfat solids-baby food/in   0.000620   1.000     
0.010   

27022240 D    Milk, water                        0.000620   1.000     
0.010   

27022241 D    Milk, water-babyfood/infant form   0.000620   1.000     
0.010   

27032251 D    Milk, sugar (lactose)-baby food/   0.000620   1.000     
0.010   

15002260 15   Millet, grain                      0.100000   1.000     
0.010   

15002310 15   Oat, bran                          0.100000   2.100     
0.010   

15002320 15   Oat, flour                         0.100000   0.440     
0.010   

15002321 15   Oat, flour-babyfood                0.100000   0.440     
0.010   

15002330 15   Oat, groats/rolled oats            0.100000   1.000     
0.010   

15002331 15   Oat, groats/rolled oats-babyfood   0.100000   1.000     
0.010   

25002900 M    Pork, meat                         0.002300   1.000     
0.010   

25002901 M    Pork, meat-babyfood                0.002300   1.000     
0.010   

25002910 M    Pork, skin                         0.001800   1.000     
0.010   

25002920 M    Pork, meat byproducts              0.014000   1.000     
0.010   

25002921 M    Pork, meat byproducts-babyfood     0.014000   1.000     
0.010   

25002930 M    Pork, fat                          0.001800   1.000     
0.010   

25002931 M    Pork, fat-babyfood                 0.001800   1.000     
0.010   

25002940 M    Pork, kidney                       0.014000   1.000     
0.010   

25002950 M    Pork, liver                        0.011000   1.000     
0.010   

60003010 P    Poultry, other, meat               0.002700   1.000     
0.010   

60003020 P    Poultry, other, liver              0.013000   1.000     
0.010   

60003030 P    Poultry, other, meat byproducts    0.013000   1.000     
0.010   

60003040 P    Poultry, other, fat                0.002000   1.000     
0.010   

60003050 P    Poultry, other, skin               0.002000   1.000     
0.010   

15003280 15   Rye, grain                         0.100000   1.000     
0.010   

15003290 15   Rye, flour                         0.100000   0.440     
0.010   

26003390 M    Sheep, meat                        0.007900   1.000     
0.010   

26003391 M    Sheep, meat-babyfood               0.007900   1.000     
0.010   

26003400 M    Sheep, meat byproducts             0.051000   1.000     
0.010   

26003410 M    Sheep, fat                         0.006400   1.000     
0.010   

26003411 M    Sheep, fat-babyfood                0.006400   1.000     
0.010   

26003420 M    Sheep, kidney                      0.051000   1.000     
0.010   

26003430 M    Sheep, liver                       0.037000   1.000     
0.010   

15003440 15   Sorghum, grain                     0.100000   1.000     
0.010   

15003450 15   Sorghum, syrup                     0.100000   1.000     
0.010   

06003470 6    Soybean, seed                      0.030000   1.000     
0.010   

06003480 6    Soybean, flour                     0.030000   1.000     
0.010   

06003481 6    Soybean, flour-babyfood            0.030000   1.000     
0.010   

06003490 6    Soybean, soy milk                  0.030000   1.000     
0.010   

06003491 6    Soybean, soy milk-babyfood or in   0.030000   1.000     
0.010   

06003500 6    Soybean, oil                       0.030000   1.000     
0.010   

06003501 6    Soybean, oil-babyfood              0.030000   1.000     
0.010   

15003810 15   Triticale, flour                   0.130000   0.440     
0.010   

15003811 15   Triticale, flour-babyfood          0.130000   0.440     
0.010   

50003820 P    Turkey, meat                       0.002700   1.000     
0.010   

50003821 P    Turkey, meat-babyfood              0.002700   1.000     
0.010   

50003830 P    Turkey, liver                      0.013000   1.000     
0.010   

50003831 P    Turkey, liver-babyfood             0.013000   1.000     
0.010   

50003840 P    Turkey, meat byproducts            0.013000   1.000     
0.010   

50003841 P    Turkey, meat byproducts-babyfood   0.013000   1.000     
0.010   

50003850 P    Turkey, fat                        0.002000   1.000     
0.010   

50003851 P    Turkey, fat-babyfood               0.002000   1.000     
0.010   

50003860 P    Turkey, skin                       0.002000   1.000     
0.010   

50003861 P    Turkey, skin-babyfood              0.002000   1.000     
0.010   

15004010 15   Wheat, grain                       0.130000   1.000     
0.010   

15004011 15   Wheat, grain-babyfood              0.130000   1.000     
0.010   

15004020 15   Wheat, flour                       0.130000   0.440     
0.010   

15004021 15   Wheat, flour-babyfood              0.130000   0.440     
0.010   

15004030 15   Wheat, germ                        0.130000   1.000     
0.010   

15004040 15   Wheat, bran                        0.130000   2.100     
0.010   

Chronic Food Only Results File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for FLUFENACET                       (1994-98
data)

Residue file name: C:\Documents and Settings\sstanton\My
Documents\DEEM-FCID Files\Flufenacet\Flufenacet Chronic\Flufenacet
Chronic Food Only.R98

                                                     Adjustment factor
#2 used.

Analysis Date 11-24-2006/09:26:17     Residue file dated:
11-24-2006/08:29:32/8

Reference dose (RfD, Chronic) = .0017 mg/kg bw/day

COMMENT 1: Flufenacet Chronic - Food Only

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.000002                
0.1%

U.S. Population (spring season)             0.000002                
0.1%

U.S. Population (summer season)             0.000002                
0.1%

U.S. Population (autumn season)             0.000002                
0.1%

U.S. Population (winter season)             0.000002                
0.1%

Northeast region                            0.000002                
0.1%

Midwest region                              0.000002                
0.1%

Southern region                             0.000002                
0.1%

Western region                              0.000002                
0.1%

Hispanics                                   0.000002                
0.1%

Non-hispanic whites                         0.000002                
0.1%

Non-hispanic blacks                         0.000002                
0.1%

Non-hisp/non-white/non-black                0.000002                
0.1%

All infants (< 1 year)                      0.000002                
0.1%

Nursing infants                             0.000001                
0.0%

Non-nursing infants                         0.000002                
0.1%

Children 1-6  yrs                           0.000005                
0.3%

Children 7-12 yrs                           0.000003                
0.2%

Females 13-19 (not preg or nursing)         0.000002                
0.1%

Females 20+ (not preg or nursing)           0.000001                
0.1%

Females 13-50 yrs                           0.000002                
0.1%

Females 13+ (preg/not nursing)              0.000002                
0.1%

Females 13+ (nursing)                       0.000002                
0.1%

Males 13-19 yrs                             0.000002                
0.1%

Males 20+ yrs                               0.000002                
0.1%

Seniors 55+                                 0.000001                
0.1%

Children 1-2 yrs                            0.000005                
0.3%

Children 3-5 yrs                            0.000005                
0.3%

Children 6-12 yrs                           0.000003                
0.2%

Youth 13-19 yrs                             0.000002                
0.1%

Adults 20-49 yrs                            0.000002                
0.1%

Adults 50+ yrs                              0.000001                
0.1%

Females 13-49 yrs                           0.000002                
0.1%

------------------------------------------------------------------------
-------

Chronic Water Only Input File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for FLUFENACET                        
1994-98 data

Residue file: C:\Documents and Settings\sstanton\My Documents\DEEM-FCID
Files\Flufenacet\Flufenacet Chronic\Flufenacet Chronic DW only_OH Corn
Scenario.R98

                                                               Adjust.
#2 used

Analysis Date 11-24-2006             Residue file dated:
11-01-2006/10:26:45/8

Reference dose (RfD) = 0.0017 mg/kg bw/day

Comment:Drinking Water Only using PRZM-EXAMS Mean for OH Corn Scenario

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

86010000 O    Water, direct, all sources         0.002230   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.002230   1.000     
1.000   

Chronic Water Only Results File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for FLUFENACET                       (1994-98
data)

Residue file name: C:\Documents and Settings\sstanton\My
Documents\DEEM-FCID Files\Flufenacet\Flufenacet Chronic\Flufenacet
Chronic DW only_OH Corn Scenario.R98

                                                     Adjustment factor
#2 used.

Analysis Date 11-24-2006/09:27:47     Residue file dated:
11-01-2006/10:26:45/8

Reference dose (RfD, Chronic) = .0017 mg/kg bw/day

COMMENT 1: Drinking Water Only using PRZM-EXAMS Mean for OH Corn
Scenario

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.000047                
2.8%

U.S. Population (spring season)             0.000047                
2.7%

U.S. Population (summer season)             0.000050                
3.0%

U.S. Population (autumn season)             0.000045                
2.7%

U.S. Population (winter season)             0.000045                
2.7%

Northeast region                            0.000043                
2.5%

Midwest region                              0.000048                
2.8%

Southern region                             0.000045                
2.6%

Western region                              0.000054                
3.2%

Hispanics                                   0.000053                
3.1%

Non-hispanic whites                         0.000046                
2.7%

Non-hispanic blacks                         0.000045                
2.6%

Non-hisp/non-white/non-black                0.000058                
3.4%

All infants (< 1 year)                      0.000154                
9.1%

Nursing infants                             0.000057                
3.4%

Non-nursing infants                         0.000191               
11.2%

Children 1-6  yrs                           0.000066                
3.9%

Children 7-12 yrs                           0.000043                
2.5%

Females 13-19 (not preg or nursing)         0.000033                
1.9%

Females 20+ (not preg or nursing)           0.000047                
2.8%

Females 13-50 yrs                           0.000045                
2.7%

Females 13+ (preg/not nursing)              0.000046                
2.7%

Females 13+ (nursing)                       0.000065                
3.8%

Males 13-19 yrs                             0.000035                
2.0%

Males 20+ yrs                               0.000042                
2.5%

Seniors 55+                                 0.000046                
2.7%

Children 1-2 yrs                            0.000070                
4.1%

Children 3-5 yrs                            0.000065                
3.8%

Children 6-12 yrs                           0.000045                
2.7%

Youth 13-19 yrs                             0.000034                
2.0%

Adults 20-49 yrs                            0.000044                
2.6%

Adults 50+ yrs                              0.000046                
2.7%

Females 13-49 yrs                           0.000044                
2.6%

------------------------------------------------------------------------
-------

Chronic Food + Water Input File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for FLUFENACET                        
1994-98 data

Residue file: C:\Documents and Settings\sstanton\My Documents\DEEM-FCID
Files\Flufenacet\Flufenacet Chronic\Flufenacet Chronic Food + Water OH
Corn Scenario.R98

                                                               Adjust.
#2 used

Analysis Date 11-24-2006             Residue file dated:
11-24-2006/08:28:20/8

Reference dose (RfD) = 0.0017 mg/kg bw/day

Comment:Flufenacet Chronic - Food and Drinking Water (IL Corn Mean)

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

15000250 15   Barley, pearled barley             0.100000   1.000     
0.010   

15000251 15   Barley, pearled barley-babyfood    0.100000   1.000     
0.010   

15000260 15   Barley, flour                      0.100000   0.440     
0.010   

15000261 15   Barley, flour-babyfood             0.100000   0.440     
0.010   

15000270 15   Barley, bran                       0.100000   2.100     
0.010   

21000440 M    Beef, meat                         0.007900   1.000     
0.010   

21000441 M    Beef, meat-babyfood                0.007900   1.000     
0.010   

21000450 M    Beef, meat, dried                  0.007900   1.920     
0.010   

21000460 M    Beef, meat byproducts              0.051000   1.000     
0.010   

21000461 M    Beef, meat byproducts-babyfood     0.051000   1.000     
0.010   

21000470 M    Beef, fat                          0.006400   1.000     
0.010   

21000471 M    Beef,fat-babyfood                  0.006400   1.000     
0.010   

21000480 M    Beef, kidney                       0.051000   1.000     
0.010   

21000490 M    Beef, liver                        0.037000   1.000     
0.010   

21000491 M    Beef, liver-babyfood               0.037000   1.000     
0.010   

15000650 15   Buckwheat                          0.100000   1.000     
0.010   

15000660 15   Buckwheat, flour                   0.100000   0.440     
0.010   

40000930 P    Chicken, meat                      0.002700   1.000     
0.010   

40000931 P    Chicken, meat-babyfood             0.002700   1.000     
0.010   

40000940 P    Chicken, liver                     0.013000   1.000     
0.010   

40000950 P    Chicken, meat byproducts           0.013000   1.000     
0.010   

40000951 P    Chicken, meat byproducts-babyfoo   0.013000   1.000     
0.010   

40000960 P    Chicken, fat                       0.002000   1.000     
0.010   

40000961 P    Chicken, fat-babyfood              0.002000   1.000     
0.010   

40000970 P    Chicken, skin                      0.002000   1.000     
0.010   

40000971 P    Chicken, skin-babyfood             0.002000   1.000     
0.010   

15001200 15   Corn, field, flour                 0.025000   1.000     
0.010   

15001201 15   Corn, field, flour-babyfood        0.025000   1.000     
0.010   

15001210 15   Corn, field, meal                  0.025000   1.000     
0.010   

15001211 15   Corn, field, meal-babyfood         0.025000   1.000     
0.010   

15001220 15   Corn, field, bran                  0.025000   1.000     
0.010   

15001230 15   Corn, field, starch                0.025000   1.000     
0.010   

15001231 15   Corn, field, starch-babyfood       0.025000   1.000     
0.010   

15001240 15   Corn, field, syrup                 0.025000   1.000     
0.010   

15001241 15   Corn, field, syrup-babyfood        0.025000   1.000     
0.010   

15001250 15   Corn, field, oil                   0.025000   1.000     
0.010   

15001251 15   Corn, field, oil-babyfood          0.025000   1.000     
0.010   

15001260 15   Corn, pop                          0.100000   1.000     
0.010   

15001270 15   Corn, sweet                        0.025000   1.000     
0.030   

15001271 15   Corn, sweet-babyfood               0.025000   1.000     
0.030   

70001450 P    Egg, whole                         0.000580   1.000     
0.010   

70001451 P    Egg, whole-babyfood                0.000580   1.000     
0.010   

70001460 P    Egg, white                         0.000580   1.000     
0.010   

70001461 P    Egg, white (solids)-babyfood       0.000580   1.000     
0.010   

70001470 P    Egg, yolk                          0.000580   1.000     
0.010   

70001471 P    Egg, yolk-babyfood                 0.000580   1.000     
0.010   

23001690 M    Goat, meat                         0.007900   1.000     
0.010   

23001700 M    Goat, meat byproducts              0.051000   1.000     
0.010   

23001710 M    Goat, fat                          0.006400   1.000     
0.010   

23001720 M    Goat, kidney                       0.051000   1.000     
0.010   

23001730 M    Goat, liver                        0.037000   1.000     
0.010   

24001890 M    Horse, meat                        0.007900   1.000     
0.010   

27002220 D    Milk, fat                          0.000620   1.000     
0.010   

27002221 D    Milk, fat - baby food/infant for   0.000620   1.000     
0.010   

27012230 D    Milk, nonfat solids                0.000620   1.000     
0.010   

27012231 D    Milk, nonfat solids-baby food/in   0.000620   1.000     
0.010   

27022240 D    Milk, water                        0.000620   1.000     
0.010   

27022241 D    Milk, water-babyfood/infant form   0.000620   1.000     
0.010   

27032251 D    Milk, sugar (lactose)-baby food/   0.000620   1.000     
0.010   

15002260 15   Millet, grain                      0.100000   1.000     
0.010   

15002310 15   Oat, bran                          0.100000   2.100     
0.010   

15002320 15   Oat, flour                         0.100000   0.440     
0.010   

15002321 15   Oat, flour-babyfood                0.100000   0.440     
0.010   

15002330 15   Oat, groats/rolled oats            0.100000   1.000     
0.010   

15002331 15   Oat, groats/rolled oats-babyfood   0.100000   1.000     
0.010   

25002900 M    Pork, meat                         0.002300   1.000     
0.010   

25002901 M    Pork, meat-babyfood                0.002300   1.000     
0.010   

25002910 M    Pork, skin                         0.001800   1.000     
0.010   

25002920 M    Pork, meat byproducts              0.014000   1.000     
0.010   

25002921 M    Pork, meat byproducts-babyfood     0.014000   1.000     
0.010   

25002930 M    Pork, fat                          0.001800   1.000     
0.010   

25002931 M    Pork, fat-babyfood                 0.001800   1.000     
0.010   

25002940 M    Pork, kidney                       0.014000   1.000     
0.010   

25002950 M    Pork, liver                        0.011000   1.000     
0.010   

60003010 P    Poultry, other, meat               0.002700   1.000     
0.010   

60003020 P    Poultry, other, liver              0.013000   1.000     
0.010   

60003030 P    Poultry, other, meat byproducts    0.013000   1.000     
0.010   

60003040 P    Poultry, other, fat                0.002000   1.000     
0.010   

60003050 P    Poultry, other, skin               0.002000   1.000     
0.010   

15003280 15   Rye, grain                         0.100000   1.000     
0.010   

15003290 15   Rye, flour                         0.100000   0.440     
0.010   

26003390 M    Sheep, meat                        0.007900   1.000     
0.010   

26003391 M    Sheep, meat-babyfood               0.007900   1.000     
0.010   

26003400 M    Sheep, meat byproducts             0.051000   1.000     
0.010   

26003410 M    Sheep, fat                         0.006400   1.000     
0.010   

26003411 M    Sheep, fat-babyfood                0.006400   1.000     
0.010   

26003420 M    Sheep, kidney                      0.051000   1.000     
0.010   

26003430 M    Sheep, liver                       0.037000   1.000     
0.010   

15003440 15   Sorghum, grain                     0.100000   1.000     
0.010   

15003450 15   Sorghum, syrup                     0.100000   1.000     
0.010   

06003470 6    Soybean, seed                      0.030000   1.000     
0.010   

06003480 6    Soybean, flour                     0.030000   1.000     
0.010   

06003481 6    Soybean, flour-babyfood            0.030000   1.000     
0.010   

06003490 6    Soybean, soy milk                  0.030000   1.000     
0.010   

06003491 6    Soybean, soy milk-babyfood or in   0.030000   1.000     
0.010   

06003500 6    Soybean, oil                       0.030000   1.000     
0.010   

06003501 6    Soybean, oil-babyfood              0.030000   1.000     
0.010   

15003810 15   Triticale, flour                   0.130000   0.440     
0.010   

15003811 15   Triticale, flour-babyfood          0.130000   0.440     
0.010   

50003820 P    Turkey, meat                       0.002700   1.000     
0.010   

50003821 P    Turkey, meat-babyfood              0.002700   1.000     
0.010   

50003830 P    Turkey, liver                      0.013000   1.000     
0.010   

50003831 P    Turkey, liver-babyfood             0.013000   1.000     
0.010   

50003840 P    Turkey, meat byproducts            0.013000   1.000     
0.010   

50003841 P    Turkey, meat byproducts-babyfood   0.013000   1.000     
0.010   

50003850 P    Turkey, fat                        0.002000   1.000     
0.010   

50003851 P    Turkey, fat-babyfood               0.002000   1.000     
0.010   

50003860 P    Turkey, skin                       0.002000   1.000     
0.010   

50003861 P    Turkey, skin-babyfood              0.002000   1.000     
0.010   

86010000 O    Water, direct, all sources         0.002230   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.002230   1.000     
1.000   

15004010 15   Wheat, grain                       0.130000   1.000     
0.010   

15004011 15   Wheat, grain-babyfood              0.130000   1.000     
0.010   

15004020 15   Wheat, flour                       0.130000   0.440     
0.010   

15004021 15   Wheat, flour-babyfood              0.130000   0.440     
0.010   

15004030 15   Wheat, germ                        0.130000   1.000     
0.010   

15004040 15   Wheat, bran                        0.130000   2.100     
0.010   

Chronic Food + Water Results File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for FLUFENACET                       (1994-98
data)

Residue file name: C:\Documents and Settings\sstanton\My
Documents\DEEM-FCID Files\Flufenacet\Flufenacet Chronic\Flufenacet
Chronic Food + Water OH Corn Scenario.R98

                                                     Adjustment factor
#2 used.

Analysis Date 11-24-2006/09:29:00     Residue file dated:
11-24-2006/08:28:20/8

Reference dose (RfD, Chronic) = .0017 mg/kg bw/day

COMMENT 1: Flufenacet Chronic - Food and Drinking Water (IL Corn Mean)

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.000049                
2.9%

U.S. Population (spring season)             0.000049                
2.9%

U.S. Population (summer season)             0.000053                
3.1%

U.S. Population (autumn season)             0.000048                
2.8%

U.S. Population (winter season)             0.000048                
2.8%

Northeast region                            0.000045                
2.6%

Midwest region                              0.000050                
2.9%

Southern region                             0.000047                
2.7%

Western region                              0.000056                
3.3%

Hispanics                                   0.000055                
3.3%

	

 

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Non-hispanic whites                         0.000048                
2.8%

Non-hispanic blacks                         0.000047                
2.7%

Non-hisp/non-white/non-black                0.000060                
3.5%

All infants (< 1 year)                      0.000156                
9.2%

Nursing infants                             0.000058                
3.4%

Non-nursing infants                         0.000193               
11.4%

Children 1-6  yrs                           0.000071                
4.2%

Children 7-12 yrs                           0.000046                
2.7%

Females 13-19 (not preg or nursing)         0.000035                
2.1%

Females 20+ (not preg or nursing)           0.000048                
2.8%

Females 13-50 yrs                           0.000047                
2.8%

Females 13+ (preg/not nursing)              0.000047                
2.8%

Females 13+ (nursing)                       0.000067                
3.9%

Males 13-19 yrs                             0.000037                
2.2%

Males 20+ yrs                               0.000044                
2.6%

Seniors 55+                                 0.000048                
2.8%

Children 1-2 yrs                            0.000075                
4.4%

Children 3-5 yrs                            0.000070                
4.1%

Children 6-12 yrs                           0.000048                
2.9%

Youth 13-19 yrs                             0.000036                
2.1%

Adults 20-49 yrs                            0.000046                
2.7%

Adults 50+ yrs                              0.000048                
2.8%

Females 13-49 yrs                           0.000045                
2.7%

------------------------------------------------------------------------
-------

Flufenacet Dietary Exposure Assessment		DP Number: 338504			PC Code:
121903

Page   PAGE  1  of   NUMPAGES  43 

Page   PAGE  13  of   NUMPAGES  43