Document ID: EPA-HQ-OPP-2008-0274-0036
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2008-09-17T04:00Z

Hi Sharlene,

As requested, here is the email exchange with Dr. Rauh on August 12.

Regards,

Debbie

Deborah Smegal

Health Effects Division 

USEPA Office of Pesticide Programs (7509P)

703-308-0175

----- Forwarded by Deborah Smegal/DC/USEPA/US on 09/10/2008 12:15 PM
-----

"Virginia A. Rauh" <var1@columbia.edu> 

08/12/2008 04:25 PM	

To

Deborah Smegal/DC/USEPA/US@EPA

cc

rmw5@columbia.edu, Anna Lowit/DC/USEPA/US@EPA

Subject

Re: Fw: newer draft of chlorpyrifos epi chapter

 

Yes,  I think it can be mentioned, especially since the MDI findings are

consistent with Robin's findings.  It is important to note that this 

suggests that exposure to one organophosphate (in this case diazinon) 

may potentiate the adverse effects of another organophosphate (in this 

case CPF), or vice-versa.  This is certainly one interpretation of our 

findings.  Additionally, it is quite clear that the adverse impact of 

CPF on birthweight and cogntive development is not due to diazinon 

exposure.  Does that help?

Smegal.Deborah@epamail.epa.gov wrote:

> Thank you Ginny.

>

> Can I mention this as a personal communcation (i.e., that even

> controlling for diazinon the effects were signifciant), or do you
prefer

> we just keep this in our internal EPA files and amongst our folks?

>

> We really appreciate all your help.

>

> Regards,

>

> Debbie

>

> Deborah Smegal

> Health Effects Division

> USEPA Office of Pesticide Programs (7509P)

> 703-308-0175

>

>

>                                                                       
 

>              "Virginia A.                                             
 

>              Rauh"                                                    
 

>              <var1@columbia.e                                       
To 

>              du>                      Deborah Smegal/DC/USEPA/US@EPA  
 

>                                                                     
cc 

>              08/12/2008 03:20         rmw5@columbia.edu               
 

>              PM                                                
Subject 

>                                       Re: Fw: newer draft of          
 

>                                       chlorpyrifos epi chapter        
 

>                                                                       
 

>                                                                       
 

>                                                                       
 

>                                                                       
 

>                                                                       
 

>                                                                       
 

>

>

>

>

> Hi Debbie and Robin--I did some re-analyses over the past few days,
just

>

> to check the effects of high diazinon exposure on 3-year development.

> With respect to the strongest effect of CPF (motor development), there

> is no significant effect of high diazinon exposure or any increase in

> the significance of the effect when CPF and Diazinon are combined. 
Re:

> mental development, there is no diazinon effect, but the magnitude of

> the deficit is slightly increased when the combined CPF and diazinon

> measure is used.  This is very similar to Robin's BW finding.  So
these

> analyses do not reduce the CPF effect for any of the 3-year outcomes. 
I

>

> think this is important for us to know but of course this is not

> published.

> Ginny

>

>