Document ID: EPA-HQ-OPP-2002-0166-0001
Agency: epa
Document Type: Notice
Title: Notice of Filing a Pesticide Petition to Establish a Tolerance for a Certain Pesticide Chemical in or on 
Food.
Posted Date: 2002-08-07T04:00Z

51260
Federal
Register
/
Vol.
67,
No.
152
/
Wednesday,
August
7,
2002
/
Notices
IV.
Public
Docket
Complete
lists
of
registrations
canceled
for
non­
payment
of
the
maintenance
fee
will
also
be
available
for
reference
during
normal
business
hours
in
the
OPP
Public
Docket,
Room
119,
Crystal
Mall
#
2,
1921
Jefferson
Davis
Highway
South,
Arlington
VA,
and
at
each
EPA
Regional
Office.
Product
 
specific
status
inquiries
may
be
made
by
telephone
by
calling
toll­
free
1
 
800
 
444
 
7255.

List
of
Subjects
Environmental
protection,
Fees.

Dated:
July
25,
2002.
Marcia
E.
Mulkey,
Director,
Office
of
Pesticide
Programs.
[
FR
Doc.
02
 
19982
Filed
8
 
6
 
02;
8:
45
a.
m.]

BILLING
CODE
6560
 
50
 
S
ENVIRONMENTAL
PROTECTION
AGENCY
[
OPP
 
2002
 
0166;
FRL
 
7190
 
4]

Notice
of
Filing
a
Pesticide
Petition
to
Establish
a
Tolerance
for
a
Certain
Pesticide
Chemical
in
or
on
Food
AGENCY:
Environmental
Protection
Agency
(
EPA).

ACTION:
Notice.

SUMMARY:
This
notice
announces
the
initial
filing
of
a
pesticide
petition
proposing
the
establishment
of
regulations
for
residues
of
a
certain
pesticide
chemical
in
or
on
various
food
commodities.

DATES:
Comments,
identified
by
docket
ID
number
OPP
 
2002
 
0166,
must
be
received
on
or
before
September
6,
2002.

ADDRESSES:
Comments
may
be
submitted
by
mail,
electronically,
or
in
person.
Please
follow
the
detailed
instructions
for
each
method
as
provided
in
Unit
I.
C.
of
the
SUPPLEMENTARY
INFORMATION.
To
ensure
proper
receipt
by
EPA,
it
is
imperative
that
you
identify
docket
ID
number
OPP
 
2002
 
0166
in
the
subject
line
on
the
first
page
of
your
response.

FOR
FURTHER
INFORMATION
CONTACT:
By
mail:
Treva
Alston,
Registration
Support
Branch,
Registration
Division
(
7505C),
Office
of
Pesticide
Programs,
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460;
telephone
number:
(
703)
308
 
8373;
e­
mail
address:
treva.
alston@
epa.
gov.

SUPPLEMENTARY
INFORMATION:
I.
General
Information
A.
Does
this
Action
Apply
to
Me?
You
may
be
affected
by
this
action
if
you
are
an
agricultural
producer,
food
manufacturer
or
pesticide
manufacturer.
Potentially
affected
categories
and
entities
may
include,
but
are
not
limited
to:

Categories
NAICS
codes
Examples
of
potentially
affected
entities
Industry
111
Crop
production
112
Animal
production
311
Food
manufacturing
32532
Pesticide
manufacturing
This
listing
is
not
intended
to
be
exhaustive,
but
rather
provides
a
guide
for
readers
regarding
entities
likely
to
be
affected
by
this
action.
Other
types
of
entities
not
listed
in
the
table
could
also
be
affected.
The
North
American
Industrial
Classification
System
(
NAICS)
codes
have
been
provided
to
assist
you
and
others
in
determining
whether
or
not
this
action
might
apply
to
certain
entities.
If
you
have
questions
regarding
the
applicability
of
this
action
to
a
particular
entity,
consult
the
person
listed
under
FOR
FURTHER
INFORMATION
CONTACT.

B.
How
Can
I
Get
Additional
Information,
Including
Copies
of
this
Document
and
Other
Related
Documents?
1.
Electronically.
You
may
obtain
electronic
copies
of
this
document,
and
certain
other
related
documents
that
might
be
available
electronically,
from
the
EPA
Internet
Home
Page
at
http://
www.
epa.
gov/.
To
access
this
document,
on
the
Home
Page
select
``
Laws
and
Regulations,''
``
Regulations
and
Proposed
Rules,''
and
then
look
up
the
entry
for
this
document
under
the
``
Federal
Register
 
Environmental
Documents.''
You
can
also
go
directly
to
the
Federal
Register
listings
at:
http://
www.
epa.
gov/
fedrgstr/.
2.
In
person.
The
Agency
has
established
an
official
record
for
this
action
under
docket
ID
number
OPP
 
2002
 
0166.
The
official
record
consists
of
the
documents
specifically
referenced
in
this
action,
any
public
comments
received
during
an
applicable
comment
period,
and
other
information
related
to
this
action,
including
any
information
claimed
as
confidential
business
information
(
CBI).
This
official
record
includes
the
documents
that
are
physically
located
in
the
docket,
as
well
as
the
documents
that
are
referenced
in
those
documents.
The
public
version
of
the
official
record
does
not
include
any
information
claimed
as
CBI.
The
public
version
of
the
official
record,
which
includes
printed,
paper
versions
of
any
electronic
comments
submitted
during
an
applicable
comment
period,
is
available
for
inspection
in
the
Public
Information
and
Records
Integrity
Branch
(
PIRIB),
Rm.
119,
Crystal
Mall
#
2,
1921
Jefferson
Davis
Highway,
Arlington,
VA,
from
8:
30
a.
m.
to
4
p.
m.,
Monday
through
Friday,
excluding
legal
holidays.
The
PIRIB
telephone
number
is
(
703)
305
 
5805.

C.
How
and
to
Whom
Do
I
Submit
Comments?
You
may
submit
comments
through
the
mail,
in
person,
or
electronically.
To
ensure
proper
receipt
by
EPA,
it
is
imperative
that
you
identify
docket
ID
number
OPP
 
2002­
0166
in
the
subject
line
on
the
first
page
of
your
response.
1.
By
mail.
Submit
your
comments
to:
Public
Information
and
Records
Integrity
Branch
(
PIRIB),
Information
Resources
and
Services
Division
(
7502C),
Office
of
Pesticide
Programs
(
OPP),
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460.
2.
In
person
or
by
courier.
Deliver
your
comments
to:
Public
Information
and
Records
Integrity
Branch
(
PIRIB),
Information
Resources
and
Services
Division
(
7502C),
Office
of
Pesticide
Programs
(
OPP),
Environmental
Protection
Agency,
Rm.
119,
Crystal
Mall
#
2,
1921
Jefferson
Davis
Highway,
Arlington,
VA.
The
PIRIB
is
open
from
8:
30
a.
m.
to
4
p.
m.,
Monday
through
Friday,
excluding
legal
holidays.
The
PIRIB
telephone
number
is
(
703)
305
 
5805.
3.
Electronically.
You
may
submit
your
comments
electronically
by
e­
mail
to:
opp­
docket@
epa.
gov,
or
you
can
submit
a
computer
disk
as
described
above.
Do
not
submit
any
information
electronically
that
you
consider
to
be
CBI.
Avoid
the
use
of
special
characters
and
any
form
of
encryption.
Electronic
submissions
will
be
accepted
in
Wordperfect
6.1/
8.0
or
ASCII
file
format.
All
comments
in
electronic
form
must
be
identified
by
docket
ID
number
OPP
 
2002
 
0166.
Electronic
comments
may
also
be
filed
online
at
many
Federal
Depository
Libraries.

D.
How
Should
I
Handle
CBI
That
I
Want
to
Submit
to
the
Agency?
Do
not
submit
any
information
electronically
that
you
consider
to
be
CBI.
You
may
claim
information
that
you
submit
to
EPA
in
response
to
this
document
as
CBI
by
marking
any
part
or
VerDate
11<
MAY>
2000
21:
23
Aug
06,
2002
Jkt
197001
PO
00000
Frm
00100
Fmt
4703
Sfmt
4703
E:\
FR\
FM\
07AUN1.
SGM
pfrm11
PsN:
07AUN1
51261
Federal
Register
/
Vol.
67,
No.
152
/
Wednesday,
August
7,
2002
/
Notices
all
of
that
information
as
CBI.
Information
so
marked
will
not
be
disclosed
except
in
accordance
with
procedures
set
forth
in
40
CFR
part
2.
In
addition
to
one
complete
version
of
the
comment
that
includes
any
information
claimed
as
CBI,
a
copy
of
the
comment
that
does
not
contain
the
information
claimed
as
CBI
must
be
submitted
for
inclusion
in
the
public
version
of
the
official
record.
Information
not
marked
confidential
will
be
included
in
the
public
version
of
the
official
record
without
prior
notice.
If
you
have
any
questions
about
CBI
or
the
procedures
for
claiming
CBI,
please
consult
the
person
identified
under
FOR
FURTHER
INFORMATION
CONTACT.

E.
What
Should
I
Consider
as
I
Prepare
My
Comments
for
EPA?

You
may
find
the
following
suggestions
helpful
for
preparing
your
comments:
1.
Explain
your
views
as
clearly
as
possible.
2.
Describe
any
assumptions
that
you
used.
3.
Provide
copies
of
any
technical
information
and/
or
data
you
used
that
support
your
views.
4.
If
you
estimate
potential
burden
or
costs,
explain
how
you
arrived
at
the
estimate
that
you
provide.
5.
Provide
specific
examples
to
illustrate
your
concerns.
6.
Make
sure
to
submit
your
comments
by
the
deadline
in
this
notice.
7.
To
ensure
proper
receipt
by
EPA,
be
sure
to
identify
the
docket
ID
number
assigned
to
this
action
in
the
subject
line
on
the
first
page
of
your
response.
You
may
also
provide
the
name,
date,
and
Federal
Register
citation.

II.
What
Action
is
the
Agency
Taking?

EPA
has
received
a
pesticide
petition
as
follows
proposing
the
establishment
and/
or
amendment
of
regulations
for
residues
of
a
certain
pesticide
chemical
in
or
on
various
food
commodities
under
section
408
of
the
Federal
Food,
Drug,
and
Cosmetic
Act
(
FFDCA),
21
U.
S.
C.
346a.
EPA
has
determined
that
this
petition
contains
data
or
information
regarding
the
elements
set
forth
in
section
408(
d)(
2);
however,
EPA
has
not
fully
evaluated
the
sufficiency
of
the
submitted
data
at
this
time
or
whether
the
data
support
granting
of
the
petition.
Additional
data
may
be
needed
before
EPA
rules
on
the
petition.

List
of
Subjects
Environmental
protection,
Agricultural
commodities,
Feed
additives,
Food
additives,
Pesticides
and
pests,
Reporting
and
recordkeeping
requirements.

Dated:
July
25,
2002.
Peter
Caukins,
Acting
Director,
Registration
Division,
Office
of
Pesticide
Programs.

Summary
of
Petition
The
petitioner
summary
of
the
pesticide
petition
is
printed
below
as
required
by
section
408(
d)(
3)
of
the
FFDCA.
The
summary
of
the
petition
was
prepared
by
the
petitioner
and
represents
the
view
of
the
petitioner.
EPA
is
publishing
the
petition
summary
verbatim
without
editing
it
in
any
way.
The
petition
summary
announces
the
availability
of
a
description
of
the
analytical
methods
available
to
EPA
for
the
detection
and
measurement
of
the
pesticide
chemical
residues
or
an
explanation
of
why
no
such
method
is
needed.

Akzo
Nobel
Surface
Chemistry
LLC
PP
7E4807
EPA
has
received
a
pesticide
petition
PP
7E4807
from
Akzo
Nobel
Surface
Chemistry
LLC,
300
South
Riverside
Plaza,
Chicago,
IL
60606,
proposing,
pursuant
to
section
408(
d)
of
the
Federal
Food,
Drug,
and
Cosmetic
Act
(
FFDCA),
21
U.
S.
C.
346a(
d),
to
amend
40
CFR
part
180.
To
establish
an
exemption
from
the
requirement
of
a
tolerance
for
[
2­
ethylhexyl
glucopyranoside]
to
be
applied
to
growing
crops
only.
EPA
has
determined
that
the
petition
contains
data
or
information
regarding
the
elements
set
forth
in
section
408(
d)(
2)
of
the
FFDCA;
however,
EPA
has
not
fully
evaluated
the
sufficiency
of
the
submitted
data
at
this
time
or
whether
the
data
support
granting
of
the
petition.
Additional
data
may
be
needed
before
EPA
rules
on
the
petition.

A.
Residue
Chemistry
1.
Plant
metabolism.
The
plant
metabolism
of
2­
ethylhexyl
glucopyranoside
has
not
been
investigated.
However,
due
to
the
structural
similarity,
the
metabolic
pathway
for
2­
ethylhexyl
glucopyranoside
is
expected
to
be
similar
to
that
of
other
alkyl
glucosides
which
have
been
previously
granted
an
exemption
from
the
requirement
of
a
tolerance,
and
also
of
those
alkyl
glucosides
of
similar
structure
that
appear
on
EPA's
current
List
4B
Inert
Ingredient
List.
2.
Analytical
method.
The
inert
ingredient,
impurities
and
oligomer
distribution
can
be
analyzed
using
high
temperature
gas
chromatography
with
cold
on
column
injection
after
derivatization
with
silylating
reagents.
Low
levels
of
the
inert
ingredient
can
be
detected
by
HPLC.
3.
Magnitude
of
residues.
Given
the
current
extensive
and
widespread
use
of
structurally
similar
nonionic
surfactants
in
herbicide
formulations,
the
added
use
of
2­
ethylhexyl
glucopyranoside
will
not
significantly
contribute
to
the
total
use­
volume
of
these
materials.
The
expected
concentration
of
2ethylhexyl
glucopyranoside
when
used
in
an
herbicide
formulation
will
be
much
lower
than
the
concentration
of
any
coformulated
pesticide
active
ingredient.
Therefore,
the
comparable
application
rate,
on
a
grams/
acre
basis
will
be
significantly
lower
than
that
of
any
coformulated
active
ingredient.
It
is
then
reasonable
to
assume
that
any
potential
residues
resulting
from
the
use
of
2­
ethylhexyl
glucopyranoside
in
a
pesticide
formulation
would
be
insignificant.

B.
Toxicological
Profile
1.
Acute
toxicity.
The
results
of
acute
toxicity
testing
for
2­
ethylhexyl
glucopyranoside
are
as
follows:
Acute
oral
LD50
(
rat)
>
2.0
gram/
kilogram
(
g/
kg);
Acute
dermal
LD50
(
rat)
>
2.38
g/
kg;
moderate
to
severe
eye
irritant
(
rabbit);
non­
irritating
to
skin
(
rabbit);
not
a
skin
sensitizer
(
guinea
pig).
2.
Genotoxicty.
2­
Ethylhexyl
glucoside
was
negative
in
the
Ames
test,
and
did
not
induce
chromosomal
aberrations
in
human
lymphocytes
cultured
in
vivo.
3.
Reproductive
and
developmental
toxicity.
Although
the
final
report
has
not
yet
been
issued,
the
preliminary
results
from
a
one­
generation
reproduction
toxicity
study
with
2­
ethylhexyl
glucoside
administered
in
male
and
female
Wistar
rats
are
available.
The
results
indicate
gavage
treatment
of
male
and
female
Wistar
rats
with
2­
ethylhexyl
glucoside
at
dose
levels
of
15,
150
or
750
milligram/
kilogram
(
mg/
kg)
body
weight/
day
during
one
generation,
revealed
parental
toxicity
in
animals
receiving
750
mg/
kg
b.
w./
day.
Reproductive
parameters
and
development
of
the
pups
were
not
affected
up
to
750
mg/
kg
b.
w./
day.
Parental
toxicity
consisted
of
affected
mortality,
clinical
signs,
body
weights,
and
food
consumption
for
animals
treated
at
750
mg/
kg
body
weight/
day.
Based
on
the
results
in
this
onegeneration
study,
the
definitive
parental
no
observed
adverse
effect
level
(
NOAEL)
was
established
as
being
150
mg/
kg
body
weight/
day.
The
definitive
reproductive
and
developmental
NOAEL
was
established
as
being
750
mg/
kg
body
weight/
day.
4.
Subchronic
toxicity.
A
28­
day
oral
toxicity
study
in
the
rat
was
conducted
VerDate
Aug<
2,>
2002
19:
43
Aug
06,
2002
Jkt
197001
PO
00000
Frm
00101
Fmt
4703
Sfmt
4703
E:\
FR\
FM\
07AUN1.
SGM
pfrm17
PsN:
07AUN1
51262
Federal
Register
/
Vol.
67,
No.
152
/
Wednesday,
August
7,
2002
/
Notices
on
2­
ethylhexyl
glucopyranoside.
The
results
were
that
in
the
rat,
750
mg/
kg/
day
represents
the
no­
observed­
toxic
effect
level
(
NOTEL)
and
150
mg/
kg/
day
represents
the
no­
observed
effect
level
(
NOEL).
5.
Chronic
toxicity.
Based
on
the
NOTEL
and
NOEL
results
of
the
28­
day
study
conducted
on
2­
ethylhexyl
glucopyranoside,
there
are
no
chronic
health
concerns.
6.
Animal
metabolism.
Animal
metabolism
studies
have
not
been
conducted
on
2­
ethylhexyl
glucopyranoside.
However,
structurally
similar
radiolabeled
alkyl
glucopyranosides
were
studied
after
oral
administration
to
mice.
The
results
indicate
that
the
glycosidic
bond
was
rapidly
hydrolyzed
in
the
intestine
and
liver
to
sugars
and
the
parent
alcohol.
The
sugars
and
alcohols
then
entered
the
pathways
of
lipid
and
carbohydrate
metabolism.
7.
Metabolite
toxicology.
The
metabolites
of
2­
ethylhexyl
glucopyranoside
are
expected
to
be
the
cleavage
products
at
the
glycosidic
bond,
2­
ethylhexanol
and
glucose.
The
toxicity
of
these
two
metabolites
is
well
known.
8.
Endocrine
disruption.
No
evidence
of
endocrine
disruption
was
observed
in
any
of
the
studies
conducted
on
2­
ethylhexyl
glucopyranoside,
nor
are
there
any
known
reports
of
any
estrogenic
and
adverse
effects
to
human
population
as
a
result
of
the
use
of
2­
ethyhexyl
glucopyranoside.

C.
Aggregate
Exposure
1.
Dietary
exposure.
Based
on
the
metabolism
study
that
indicates
alkyl
glucopyranosides
are
readily
metabolized
in
the
liver
and
intestine
to
glucose
and
the
alcohol,
exposure
to
2­
ethylhexyl
glucopyranoside
should
not
pose
a
dietary
risk
under
any
foreseeable
circumstances
to
the
U.
S.
population
including
infants
and
children.
i.
Food.
Exposures
to
2­
ethylhexyl
glucopyranoside
due
to
ingestion
of
food
is
not
expected
to
occur.
ii.
Drinking
water.
Exposures
to
2­
ethylhexyl
glucopyranoside
due
to
ingestion
of
water
is
not
expected
to
occur.
2.
Non­
dietary
exposure.
Structurally
similar
alkyl
glucopyranosides
are
currently
being
used
in
a
number
of
institutional
and
household
cleaning
applications.
These
current
uses
are
expected
to
result
in
significantly
higher
exposures
than
exposure
due
to
the
insignificant
residue
levels
resulting
from
the
use
under
the
proposed
exemption
from
the
requirement
of
a
tolerance
applied
to
growing
crops
only.
D.
Cumulative
Effects.
From
the
results
of
the
tests
conducted
on
2­
ethylhexyl
glucopyranoside,
no
evidence
of
any
specific
target
organ
toxicity
has
been
produced.
Therefore,
there
is
no
evidence
of
a
common
mechanism
of
toxicity
with
any
other
substance,
and
there
is
no
reason
to
expect
that
the
use
of
2­
ethyhexyl
glucopyranoside
will
contribute
to
any
cumulative
toxicity
resulting
from
exposures
to
other
substances
having
a
common
mechanism
of
toxicity.

E.
Safety
Determination
1.
U.
S.
population.
The
results
of
the
acute,
genotoxic,
subacute
and
developmental
toxicity
studies
conducted
on
2­
ethylhexyl
glucopyranoside
indicate
a
relatively
low
order
of
toxicity.
Structurally
similar
alkyl
glucopyranosides
currently
exempted
from
the
requirement
of
a
tolerance,
also
appear
on
EPA's
List
4B
Inert
List.
Therefore,
due
to
the
low
order
of
toxicity
of
2­
ethylhexyl
glucopyranoside
and
the
lack
of
known
adverse
human
health
effects
associated
with
this
class
of
chemicals,
the
exemption
from
the
requirement
of
a
tolerance
on
growing
crops
only
is
not
expected
to
result
in
any
new,
or
adverse
effects
to
human
health
or
the
environment.
2.
Infants
and
children.
Exposure
to
2­
ethylhexyl
glucopyranosides
to
infants
and
children
is
not
expected
to
occur.
The
substance
will
be
used
as
an
inert
ingredient
at
low
levels
on
growing
crops
only,
and
any
residual
levels
are
expected
to
be
insignificant
and
consistent
with
structurally
similar
alkyl
glucopyranosides
currently
exempted
from
the
requirement
of
a
tolerance.

F.
International
Tolerances
No
codex
maximum
residue
levels
have
been
established
for
2­
ethyhexyl
glucopyranoside.
[
FR
Doc.
02
 
19805
Filed
8
 
6
 
02;
8:
45
am]

BILLING
CODE
6560
 
50
 
S
ENVIRONMENTAL
PROTECTION
AGENCY
[
OPP
 
2002
 
0151;
FRL
 
7188
 
6]

Notice
of
Filing
a
Pesticide
Petition
to
Establish
a
Tolerance
for
a
Certain
Pesticide
Chemical
in
or
on
Food
AGENCY:
Environmental
Protection
Agency
(
EPA).
ACTION:
Notice.

SUMMARY:
This
notice
announces
the
initial
filing
of
a
pesticide
petition
proposing
the
establishment
of
regulations
for
residues
of
a
certain
pesticide
chemical
in
or
on
various
food
commodities.

DATES:
Comments,
identified
by
docket
ID
number
OPP
 
2002
 
0151,
must
be
received
on
or
before
September
6,
2002.

ADDRESSES:
Comments
may
be
submitted
by
mail,
electronically,
or
in
person.
Please
follow
the
detailed
instructions
for
each
method
as
provided
in
Unit
I.
C.
of
the
SUPPLEMENTARY
INFORMATION.
To
ensure
proper
receipt
by
EPA,
it
is
imperative
that
you
identify
docket
ID
number
OPP
 
2002
 
0151
in
the
subject
line
on
the
first
page
of
your
response.

FOR
FURTHER
INFORMATION
CONTACT:
By
mail:
Sidney
Jackson,
Registration
Division
(
7505C),
Office
of
Pesticide
Programs,
Environmental
Protection
Agency,
1200
Pennsylvania
Ave.,
NW.,
Washington,
DC
20460;
telephone
number:
(
703)
305
 
7610;
e­
mail
address:
jackson.
sidney@
epa.
gov.

SUPPLEMENTARY
INFORMATION:

I.
General
Information
A.
Does
this
Action
Apply
to
Me?

You
may
be
affected
by
this
action
if
you
are
an
agricultural
producer,
food
manufacturer
or
pesticide
manufacturer.
Potentially
affected
categories
and
entities
may
include,
but
are
not
limited
to:

Categories
NAICS
codes
Examples
of
potentially
affected
entities
Industry
111
Crop
production
112
Animal
production
311
Food
manufacturing
32532
Pesticide
manufacturing
This
listing
is
not
intended
to
be
exhaustive,
but
rather
provides
a
guide
for
readers
regarding
entities
likely
to
be
affected
by
this
action.
Other
types
of
entities
not
listed
in
the
table
could
also
be
affected.
The
North
American
Industrial
Classification
System
(
NAICS)
codes
have
been
provided
to
assist
you
and
others
in
determining
whether
or
not
this
action
might
apply
to
certain
entities.
If
you
have
questions
regarding
the
applicability
of
this
action
to
a
particular
entity,
consult
the
person
listed
under
FOR
FURTHER
INFORMATION
CONTACT.

VerDate
Aug<
2,>
2002
19:
43
Aug
06,
2002
Jkt
197001
PO
00000
Frm
00102
Fmt
4703
Sfmt
4703
E:\
FR\
FM\
07AUN1.
SGM
pfrm17
PsN:
07AUN1