Document ID: EPA-HQ-OPP-2007-0987-0005
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2008-08-27T04:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460      

	OFFICE OF PREVENTION, PESTICIDE

	AND TOXIC SUBSTANCES

	

  SEQ CHAPTER \h \r 1 MEMORANDUM

Date:  6/12/2008

SUBJECT:  Ingredient:  Fenbuconazole

		Title:  Acute, Chronic, and Cancer Aggregate Dietary (Food and
Drinking Water) Exposure Analysis for the Section 3 Registration Action 

 

PC Code:  129011 	DP Number:  350321  

Decision No.:  383131	Registration No.:  62719-421 

Petition Nos.:  7E7256	Regulatory Action:  Section 3 

Risk Assessment Type:  None 	Case No.:  None 

TXR No.: None	CAS No.:  114369-43-6

MRID No.:   None	40 CFR:  180.480

		              							

	          	

FROM:  	Douglas Dotson, Ph.D., Chemist

	Registration Action Branch 2

	Health Effects Division (7509P)  SEQ CHAPTER \h \r 1 		

		

THROUGH:	Thurston Morton, Chemist

		Sarah Winfield, Biologist

		Richard Loranger, Ph.D., Senior Scientist

	Registration Action Branch 2

Health Effects Division (7509P)  SEQ CHAPTER \h \r 1 	

		

TO:		Sidney Jackson/Barbara Madden, RIMUERB

		and

		John Bazuin/Tony Kish, RM 22, Fungicide Branch

		Registration Division (7505P)

Executive Summary

sing the Dietary Exposure Evaluation Model DEEM-FCID™, Version 2.03. 
This model uses food consumption data from the U.S. Department of
Agriculture’s Continuing Surveys of Food Intakes by Individuals
(CSFII) from 1994-1996 along with a supplemental children’s survey
from 1998.  The analyses were based on fenbuconazole residues in food
and drinking water.  

   

Acute Dietary Exposure Results and Characterization

The acute dietary exposure analysis is based on tolerance-level residues
and assumes 100% crop treated.  As such, it is highly conservative with
respect to evaluating potential impacts of acute dietary exposure to
fenbuconazole on human health.  The only population subgroup that is
relevant for this acute assessment is females of child-bearing age
(i.e., females 13-49 years old).  The acute risk estimate that results
from this analysis is 3.1% of the acute population adjusted dose (aPAD)
at the 95th percentile of exposure.  This risk estimate is considerably
lower than HED’s level of concern (100% of the aPAD).

Chronic Dietary (Food and Drinking Water) Exposure Results and
Characterization

The chronic (non-cancer) dietary analysis is more refined because it
uses average residues from field trials.  Because of the manner in which
these data were submitted and reviewed, multiple averages were
calculated for many of the crops.  For these crops, the highest average
was used in the analysis.  The non-cancer dietary analysis assumes 100%
crop treated.  The most highly exposed population subgroup is All
Infants (<1 year old) which utilizes 6.8% of the chronic population
adjusted dose (cPAD).  The risk estimate for the general U.S. population
is 2.3% of the cPAD.  As with the acute assessment, the risk estimates
are all well below HED’s level of concern (100% of the cPAD).

Cancer Dietary Exposure Results and Characterization

The cancer dietary analysis uses the same food residue inputs as those
used in the chronic non-cancer assessment.  The cancer analysis is
further refined in that it makes use of average percent crop treated
estimates.  The cancer risk estimate using these food residue inputs and
a worst case use pattern assumption for water is 1.7 x 10-6.  Typically,
HED is concerned when the risk estimate associated with food and
drinking water exceeds 3 x 10-6.  As a result, cancer risk to the
general U.S. population is below HED’s level of concern.

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to the point of departure (e.g., NOAEL,
LOAEL) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  HED is generally
concerned when estimated cancer risk exceeds three in one million. 
References that discuss the acute and chronic risk assessments in more
detail are available on the EPA/pesticides website:  “Available
Information on Assessing Exposure from Pesticides, A User’s Guide,”
6/21/2000, web link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see
SOP 99.6 (8/20/1999).  The last dietary exposure analysis performed for
fenbuconazole was done so in 2006 in support of tolerance petitions for
several commodities (Memo, D329595, M. Doherty, 8/2/2006). 

II.	Residue Information

For peppers, the tolerance level of 0.40 ppm was used as the residue
value in the acute, chronic, and cancer dietary exposure analyses. 
Residue values used for all other commodities are discussed in detail in
the previous dietary exposure memo performed for fenbuconazole (Memo,
D329595, M. Doherty, 8/2/2006).  Table 1, below, was taken directly from
this memo and peppers were added.  Tolerances for fenbuconazole are
listed in 40CFR§180.480.  The tolerance list includes time-limited
tolerances that were established in conjunction with Section 18
registrations.  These tolerances are for the fat and meat of cattle,
goats, hogs, horses, and sheep (and one for hog, meat byproducts). 
These time-limited tolerances are all set to expire on 12/31/2008.  As
there are no Section 18 uses on animal feed items, these animal
commodity tolerances are no longer necessary (electronic communication,
D. Rosenblatt, 5/16/2008).  Therefore, these animal commodities were
excluded from the dietary assessments.  There is also an expired
blueberry Section 18 tolerance that differs from the bushberry
tolerance.  This tolerance was also excluded from the dietary exposure
analyses.

The petitioner has submitted adequate studies describing residues of
fenbuconazole and its residues of concern in almonds, apples, bananas,
blueberries, citrus, cranberries, grapes, peanuts, pecans, peppers,
stone fruit, sugar beets, and wheat.  Residue estimates for the chronic
and cancer assessments are based on all of the submitted data (often
from slightly exaggerated rate studies) and not only on the data used to
set the tolerances.  The residue estimates used in these assessments are
directly from the field trial data and, by nature of the analytical
methods, account for all of the residues of concern in crops and
livestock (fenbuconazole, lactone metabolites RH-9129 and RH-9130, and
the hydroxyl metabolite RH-4911 (peanuts only) and its glycosyl
conjugate RH-7905 (peanuts only)).  Crop field trials with the
above-listed commodities resulted in measurable residues of concern for
all crops.  The residues are summarized in Table 1 and complete listings
of the residue estimates are included as Attachments 1, 3, and 5 (acute,
chronic non-cancer, and cancer assessments, respectively).

 acute assessment includes DEEM™ Version 7.81 default processing
factors for those commodities that were not addressed by the available
processing studies.  For commodities where there is evidence that
residues do not concentrate during processing, a factor of one was used
even if there is a DEEM™ Version 7.81 default processing factor
greater than one.

he chronic assessments use DEEM™ version 7.81 default processing
factors for commodities that do not have empirical processing factors. 
The non-cancer assessment assumes 100% crop treated, whereas the cancer
assessment makes use of average percent-crop-treated estimates.  These
estimates were provided by the Biological and Economic Analysis Division
(see Attachment 7). 

Table 1.  Summary of Residues and Factors Used in the Acute, Chronic,
and Cancer Dietary Assessments for Fenbuconazole.  

Food Name	Acute Residue Estimate

(Tolerance)

(ppm)	Acute Processing Factor	Chronic Residue Estimate

(ppm)	Chronic Processing Factor	% Crop Treated

(Avg.)	Remarks for Chronic and Cancer Assessment

Almond	0.05	1	0.015	1	100

	Almond, oil	0.05	1	0.015	1	100

	Apple, fruit with peel	0.4	1	0.142	1	1

	Apple, peeled fruit	0.4	1	0.142	1	1

	Apple, dried	0.4	8	0.142	8	1	Default Proc. Factor

Apple, juice	0.4	1	0.142	0.059	1	Empirical Proc. Factor

Apple, sauce	0.4	1	0.142	1	1

	Apricot	1	1	0.307	1	10	Average Peach Value

Apricot, dried	1	6	0.307	6	10	Default Proc. Factor

Apricot, juice	1	1	0.307	1	10

	Banana	0.3	1	0.028	1	100

	Banana, dried	0.3	3.9	0.028	3.9	100	Default Proc. Factor

Beef, meat byproducts	0.05	1	0.05	1	100

	Beet, sugar	0.3	1	0.061	1	100

	Beet, sugar, molasses	0.4	1	0.061	1.8	100	Empirical Proc. Factor

Blueberry	0.3	1	0.3	1	40

	Cherry	1	1	0.336	1	20

	Cherry, juice	1	1	0.336	1.0	20	No concentration in juice

Citrus citron	1	1	0.073	1	100	Lemon Pulp

Citrus hybrids	1	1	0.073	1	100	Lemon Pulp

Citrus, oil	40	1	0.073	47	100	Lemon Pulp + Empirical Proc. Factor

Cranberry	0.5	1	0.199	1	100

	Cranberry, dried	0.5	1	0.199	1	100

	Cranberry, juice	0.5	1.1	0.199	1.1	100	Default Processing Factor

Currant	0.3	1	0.093	1	100

	Currant, dried	0.3	1	0.093	1	100

	Elderberry	0.3	1	0.093	1	100

	Goat, meat byproducts	0.05	1	0.05	1	100

	Gooseberry	0.3	1	0.093	1	100

	Grape	1	1	0.39	1	100

	Grape, juice	1	1	0.39	0.18	100	Empirical Proc. Factor

Grape, leaves	1	1	0.39	1	100

	Grape, raisin	1	4.3	0.39	4.3	100	Default Proc. Factor

Grape, wine and sherry	1	1	0.39	0.7	100	Empirical Proc. Factor

Grapefruit	1	1	0.016	1	40

	Grapefruit, juice	1	1	0.016	0.2	40	Citrus Juice Proc. Factor (chronic)

Huckleberry	0.3	1	0.093	1	100

	Kumquat	1	1	0.073	1	100

	Lemon	1	1	0.073	1	100

	Lemon, juice	1	1	0.073	0.2	100	Citrus Juice Proc. Factor (chronic)

Lemon, peel	1	1	0.652	1	100

	Lime	1	1	0.073	1	100

	Lime, juice	1	1	0.073	0.2	100	Citrus Juice Proc. Factor (chronic)

Nectarine	1	1	0.307	1	10

	Orange	1	1	0.017	1	1

	Orange, juice	1	1	0.017	0.2	1	Citrus Juice Proc. Factor (chronic)

Orange, peel	1	1	0.652	1	1

	Peach	1	1	0.307	1	15

	Peach, dried	1	7	0.307	7	15	Default Processing Factor

Peach, juice	1	1	0.307	1.0	15

	Peanut	0.1	1	0.035	1	100

	Peanut, butter	0.1	1.89	0.035	1.89	100	Default Processing Factor

Peanut, oil	0.1	1	0.035	1	100

	Pecan	0.05	1	0.015	1	15

	Peppers	0.40	1	0.40	1	100

	Plantain	0.3	1	0.028	1	100

	Plantain, dried	0.3	3.9	0.028	3.9	100	Default Processing Factor

Plum	1	1	0.063	1	100

	Plum, prune, fresh	1	1	0.063	1	1

	Plum, prune, dried	1	5	0.063	3.4	1	Default/Empirical Proc. Factors

Plum, prune, juice	1	1	0.063	1.0	1	No concentration in juice

Pummelo	1	1	1	1	100

	Sheep, meat byproducts	0.05	1	0.05	1	100

	Tangerine	1	1	0.073	1	1	Lemon Pulp

Tangerine, juice	1	1	0.073	0.2	1	Lemon Pulp + Citrus Juice Proc Factor

Wheat, grain	0.1	1	0.017	1	100

	Wheat, flour	0.1	1	0.017	0.15	100	Empirical Processing Factor

Wheat, germ	0.1	1	0.017	0.85	100	Empirical Processing Factor

Wheat, bran	0.1	1	0.017	1.4	100	Empirical Processing Factor

III.  Drinking Water Data

The estimated drinking water concentrations (EDWCs) used in the dietary
risk assessments were provided by the Environmental Fate and Effects
Division (EFED, D44352, J. Lin, 1/16/2008).  The EDWCs were incorporated
directly into these dietary assessments in the food categories “water,
direct, all sources” and “water, indirect, all sources.”  The
EDWCs for fenbuconazole were generated with the coupled models PRZM and
EXAMS for surface water and SCI-GROW for groundwater.  Modeled surface
water EDWCs are based on the maximum label application rate to peppers
(acute value) or cherries (chronic and cancer values).  The groundwater
EDWC is based on the maximum label application rate to cherries.  EDWCs
reflect exposure to fenbuconazole, per se.  The common triazole
metabolites 1,2,4-triazole, triazole alanine, and triazole acetic acid
have been identified as residues of concern for risk assessment.  A
separate dietary exposure assessment has been performed for these
metabolites (Memo, D350314, M. Doherty, 3/27/2008).  As a result, they
are not being included in this assessment.

The PRZM/EXAMS 1-in-10 year annual peak surface water value of 24.1 ppb
for peppers is greater than the SCI-GROW groundwater value of 0.031 ppb.
 As a result, the surface water value was used in the acute dietary
analysis.  The 1 in 10 year annual mean surface water value of 16.5 ppb
for cherries is greater than the groundwater value of 0.031 ppb.  As a
result, the surface water value was used in the chronic dietary
analysis.  Finally, the 30-year annual mean surface water value of 11.7
ppb for cherries is greater than the groundwater value of 0.031 ppb.  As
a result, the surface water value was used in the cancer dietary
analysis.  The SCI-GROW Model and its description are available at the
EPA internet site:    HYPERLINK
"http://www.epa.gov/oppefed/models/water/" 
http://www.epa.gov/oppefed/models/water/ .

IV.	DEEM-FCID™ Program and Consumption Information

Fenbuconazole acute and chronic dietary exposure assessments were
conducted using the DEEM-FCID (Version 2.03), which incorporates
consumption data from USDA’s CSFII (1994-1996 and 1998).  The 1994-96,
98 data are based on the reported consumption of more than 20,000
individuals over two non-consecutive survey days.  Foods “as
consumed” (e.g., apple pie) are linked to EPA-defined food commodities
(e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicly available recipe
translation files developed jointly by USDA/ARS and EPA.  For chronic
exposure assessment, consumption data are averaged for the entire U.S.
population and within population subgroups.  For acute exposure
assessment the data are retained as individual consumption events. 
Based on analysis of the 1994-96, 98 CSFII consumption data, which took
into account dietary patterns and survey respondents, HED concluded that
it is most appropriate to report risk for the following population
subgroups: the general U.S. population, all infants (<1 year old),
children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49,
females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form.  The resulting residue
consumption estimate for each food/food form is summed with the residue
consumption estimates for all other food/food forms on the commodity
residue list to arrive at the total average estimated exposure. 
Exposure is expressed in mg/kg body weight/day and as a percent of the
cPAD.  This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data
are used on an individual-by-individual basis.  The reported consumption
amounts of each food item can be multiplied by a residue point estimate
and summed to obtain a total daily pesticide exposure for a
deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., those who reported eating
relevant commodities/food forms) and a per-capita (i.e., those who
reported eating the relevant commodities as well as those who did not)
basis.  In accordance with HED policy, per capita exposure and risk are
reported for all tiers of analysis.  However, for less-refined analyses,
significant differences in user vs. per capita exposure and risk are
identified and noted in the risk assessment.  In this case, there were
no significant differences.

IV.	Toxicological Information

The toxicological doses and endpoints for use in fenbuconazole dietary
assessments are summarized in Table 2.

Table 2.  Summary of Toxicological Doses and Endpoints for Use in
Dietary Human Health Risk Assessments for Fenbuconazole

Exposure

Scenario	Dose Used in Risk Assessment, UF 	Special FQPA SF and Level of
Concern for Risk Assessment	Study and Toxicological Effects

Acute Dietary

(Females 13-49 years of age)	NOAEL = 30 mg/kg/day

UF = 100

Acute RfD = 0.3 mg/kg	FQPA SF =1

aPAD = acute RfD

              FQPA SF

= 0.3 mg/kg	Developmental rat study

Developmental LOAEL = 75 mg/kg/day based on increased resorptions and
decreased live fetuses per dam.

Acute Dietary (General population including infants and children)	None

	None	Not selected.

No appropriate dose and endpoint could be identified for these
population groups.

Chronic Dietary

(All populations)	NOAEL= 3 mg/kg/day

UF = 100

Chronic RfD = 0.03 mg/kg/day	FQPA SF =1

cPAD = 

chronic RfD

 FQPA SF

= 0.03 mg/kg/day	Combined chronic toxicity/ carcinogenicity - Rat

LOAEL = 30.6/43.1 (M/F) mg/kg/day based on decreased body weight gain,
increased thyroid weight, and histopathological lesions in the liver and
thyroid gland



Cancer (oral, dermal, inhalation)	Classification: Under the 1986 cancer
classification scheme, fenbuconazole was classified as a Group C -
Possible Human Carcinogen, with a low dose extrapolation model applied
to the animal data for the quantification of human risk (Q1*).  This
classification was based on increased incidence of hepatocellular
adenomas and carcinomas in male and female mice and of thyroid
follicular adenomas and combined adenomas/carcinomas in male rats. 
Based on mechanistic data, quantification of risk was derived using
combined hepatocellular adenomas/carcinomas in female mice.  The upper
bound estimate of unit risk, Q1* (mg/kg/day)-1 is 3.59 x 10-3 in human
equivalents.   

VI.	Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned
when dietary risk exceeds 100% of the PAD.  The DEEM-FCID™ analyses
estimate the dietary exposure of the U.S. population and various
population subgroups.  The results of the acute dietary exposure
analysis for the population subgroup Females 13-49 are reported in Table
3.  Table 4 lists the results of the chronic and cancer dietary exposure
analyses, along with the results of the acute analysis at the regulated
percentile of exposure (i.e., the 95th).  Table 4 lists the results for
the general U.S. Population, all infants (<1 year old), children 1-2,
children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49,
and adults 50+ years.  Cancer risk is determined for the general U.S.
population only.

Results of Acute Dietary Exposure Analysis

The results of the acute dietary exposure analysis at the 95th, 99th,
and 99.9th percentiles of exposure are reported in Table 3.  As percent
crop treated estimates were not used in the assessment, HED recommends
that the 95th percentile of exposure be used for regulation.  The
population subgroup Females 13-49 utilizes 3.1% of the aPAD at the 95th
percentile of exposure.  

Table 3.  Results of Acute Dietary Exposure Analysis

(Food and Drinking Water)

Population Subgroup	

aPAD (mkd)*	

95th Percentile	

99th Percentile	

99.9th Percentile

Exposure (mkd)	

% aPAD	

Exposure (mkd)	

% aPAD	

Exposure (mkd)	

% aPAD

Females 13-49 years old 	0.30	

0.009155	3.1	

0.015124	5.0	

0.027302	9.1

*mkd: milligram per kilogram body weight per day

Results of Chronic Dietary Exposure Analysis

In the chronic dietary exposure analysis, the most highly exposed
population subgroup is All Infants (<1 year old) which utilizes 6.8% of
the cPAD.  The general U.S. population utilizes 2.3% of the cPAD.

Results of Cancer Dietary Exposure Analysis

Cancer risk is determined for the general U.S. population only. 
Applying the Q* value of 0.00359 (mg/kg/day)-1 to the exposure value of
0.000473 mg/kg/day yields a cancer risk estimate of 1.7 x 10-6.

Table 4.  Summary of Dietary Exposure and Risk for Fenbuconazole

(Food and Drinking Water)

Population Subgroup*	

Acute Dietary

(95th Percentile)	

Chronic Dietary	

Cancer

	

Dietary Exposure (mg/kg/day)	

% aPAD	

Dietary Exposure

(mg/kg/day)	

% cPAD	

Dietary Exposure

(mg/kg/day)	

Risk

General U.S. Population	N/A	N/A	

0.000700	2.3	

0.000473	

1.7 x 10-6

All Infants (< 1 year old)	N/A	N/A	

0.002027	6.8

Children 1-2 years old	N/A	N/A	

0.001842	6.1

Children 3-5 years old	N/A	N/A	

0.001450	4.8

Children 6-12 years old	N/A	N/A	

0.000812	2.7

Youth 13-19 years old	N/A	N/A	

0.000440	1.5

Adults 20-49 years old	N/A	N/A	

0.000563	1.9

Adults 50+ years old	N/A	N/A	

0.000645	2.2

Females 13-49 years old	

0.009155	3.1	

0.000572	1.9

VII.	Characterization of Inputs/Outputs

In the acute and chronic (non-cancer) dietary exposure analyses,
conservative estimates of food residue levels and drinking water
concentrations were used.  In addition, it was assumed that 100% of the
commodities with fenbuconazole tolerances would be treated.  Further
refinements could be made to these analyses, but they are not necessary
at the present time.

Several refinements were made to the cancer dietary exposure analysis,
however.  As explained in the residue information section of this memo,
for many crops, the highest per-study-volume average field trial residue
values were used for the residue estimates.  The tolerance level was
used for peppers.  Field trials were performed using the maximum
application rate (and in some cases, slightly exaggerated rates) and the
minimum PHI specified on the label.  For economic reasons, farmers often
do not use the maximum label rates.  They use the minimum amount of
pesticide necessary to obtain the desired results.  From extensive past
experience, HED has observed that monitoring data are much lower in
magnitude than field trial data.  As a result, as monitoring data become
available for more of the registered and proposed commodities, any
future dietary analyses for fenbuconazole would likely produce lower
risk estimates than does the current analysis.  The analyses could also
be further refined by the translation of processing factors.  For
example, the citrus juice processing factor could have been translated
to some of the other juices such as cherry, peach, prune, and cranberry
juice.

Conclusions

Based on conservative assumptions, the acute dietary risk estimate for
the population subgroup Females 13-49 is well below HED’s level of
concern.  The chronic (non-cancer) dietary risk estimates are also based
on conservative assumptions and are well below HED’s level of concern.
 Finally, the cancer dietary risk estimate for the general U.S.
population is also below HED’s level of concern.

List of Attachments:

Attachment 1:  Residue Input File for Acute Analysis

Attachment 2:  Results of Acute Dietary Exposure Analysis

Attachment 3:  Residue Input File for Chronic (Non-Cancer) Analysis

Attachment 4:  Results of Chronic Dietary Exposure Analysis

Attachment 5:  Residue Input File for Cancer Analysis

Attachment 6:  Results of Cancer Dietary Exposure Analysis

Attachment 7:  Screening Level Usage Analysis (SLUA) Attachment 1: 
Residue Input File for Acute Analysis

NOAEL (acute) = 30 mg/kg/day

aPAD = 0.3 mg/kg/day

Filename:
C:\DocumentsandSettings\ddotson\MyDocuments\DEEMFCID\Fenbuconazole\Fenbu
conAC.R98

Date created/last modified: 05-30-2008/9:53:13/8

------------------------------------------------------------------------
------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

01010520 1A   Beet, sugar                        0.300000   1.000  1.000
 

01010521 1A   Beet, sugar-babyfood               0.300000   1.000  1.000
 

01010530 1A   Beet, sugar, molasses              0.400000   1.000  1.000
 

01010531 1A   Beet, sugar, molasses-babyfood     0.400000   1.000  1.000
 

08002700 8    Pepper, bell                       0.400000   1.000  1.000
 7E7256

08002701 8    Pepper, bell-babyfood              0.400000   1.000  1.000
 7E7256

08002710 8    Pepper, bell, dried                0.400000   1.000  1.000
 7E7256

08002711 8    Pepper, bell, dried-babyfood       0.400000   1.000  1.000
 7E7256

08002720 8    Pepper, nonbell                    0.400000   1.000  1.000
 7E7256

08002721 8    Pepper, nonbell-babyfood           0.400000   1.000  1.000
 7E7256

08002730 8    Pepper, nonbell, dried             0.400000   1.000  1.000
 7E7256

10001060 10   Citrus citron                      1.000000   1.000  1.000
 

10001070 10   Citrus hybrids                     1.000000   1.000  1.000
 

10001080 10   Citrus, oil                       40.000000   1.000  1.000
 

10001800 10   Grapefruit                         1.000000   1.000  1.000
 

10001810 10   Grapefruit, juice                  1.000000   1.000  1.000
 

10001970 10   Kumquat                            1.000000   1.000  1.000
 

10001990 10   Lemon                              1.000000   1.000  1.000
 

10002000 10   Lemon, juice                       1.000000   1.000  1.000
 

10002001 10   Lemon, juice-babyfood              1.000000   1.000  1.000
 

10002010 10   Lemon, peel                        1.000000   1.000  1.000
 

10002060 10   Lime                               1.000000   1.000  1.000
 

10002070 10   Lime, juice                        1.000000   1.000  1.000
 

10002071 10   Lime, juice-babyfood               1.000000   1.000  1.000
 

10002400 10   Orange                             1.000000   1.000  1.000
 

10002410 10   Orange, juice                      1.000000   1.000  1.000
 

10002411 10   Orange, juice-babyfood             1.000000   1.000  1.000
 

10002420 10   Orange, peel                       1.000000   1.000  1.000
 

10003070 10   Pummelo                            1.000000   1.000  1.000
 

10003690 10   Tangerine                          1.000000   1.000  1.000
 

10003700 10   Tangerine, juice                   1.000000   1.000  1.000
 

11000070 11   Apple, fruit with peel             0.400000   1.000  1.000
 

11000080 11   Apple, peeled fruit                0.400000   1.000  1.000
 

11000081 11   Apple, peeled fruit-babyfood       0.400000   1.000  1.000
 

11000090 11   Apple, dried                       0.400000   8.000  1.000
 

11000091 11   Apple, dried-babyfood              0.400000   8.000  1.000
 

11000100 11   Apple, juice                       0.400000   1.000  1.000
 

11000101 11   Apple, juice-babyfood              0.400000   1.000  1.000
 

11000110 11   Apple, sauce                       0.400000   1.000  1.000
 

11000111 11   Apple, sauce-babyfood              0.400000   1.000  1.000
 

12000120 12   Apricot                            1.000000   1.000  1.000
 

12000121 12   Apricot-babyfood                   1.000000   1.000  1.000
 

12000130 12   Apricot, dried                     1.000000   6.000  1.000
 

12000140 12   Apricot, juice                     1.000000   1.000  1.000
 

12000141 12   Apricot, juice-babyfood            1.000000   1.000  1.000
 

12000900 12   Cherry                             1.000000   1.000  1.000
 

12000901 12   Cherry-babyfood                    1.000000   1.000  1.000
 

12000910 12   Cherry, juice                      1.000000   1.000  1.000
 

12000911 12   Cherry, juice-babyfood             1.000000   1.000  1.000
 

12002300 12   Nectarine                          1.000000   1.000  1.000
 

12002600 12   Peach                              1.000000   1.000  1.000
 

12002601 12   Peach-babyfood                     1.000000   1.000  1.000
 

12002610 12   Peach, dried                       1.000000   7.000  1.000
 

12002611 12   Peach, dried-babyfood              1.000000   7.000  1.000
 

12002620 12   Peach, juice                       1.000000   1.000  1.000
 

12002621 12   Peach, juice-babyfood              1.000000   1.000  1.000
 

12002850 12   Plum                               1.000000   1.000  1.000
 

12002851 12   Plum-babyfood                      1.000000   1.000  1.000
 

12002860 12   Plum, prune, fresh                 1.000000   1.000  1.000
 

12002861 12   Plum, prune, fresh-babyfood        1.000000   1.000  1.000
 

12002870 12   Plum, prune, dried                 1.000000   5.000  1.000
 

12002871 12   Plum, prune, dried-babyfood        1.000000   5.000  1.000
 

12002880 12   Plum, prune, juice                 1.000000   1.000  1.000
 

12002881 12   Plum, prune, juice-babyfood        1.000000   1.000  1.000
 

13020570 13B  Blueberry                          0.300000   1.000  1.000
 

13020571 13B  Blueberry-babyfood                 0.300000   1.000  1.000
 

13021360 13B  Currant                            0.300000   1.000  1.000
 

13021370 13B  Currant, dried                     0.300000   1.000  1.000
 

13021490 13B  Elderberry                         0.300000   1.000  1.000
 

13021740 13B  Gooseberry                         0.300000   1.000  1.000
 

13021910 13B  Huckleberry                        0.300000   1.000  1.000
 

14000030 14   Almond                             0.050000   1.000  1.000
 

14000031 14   Almond-babyfood                    0.050000   1.000  1.000
 

14000040 14   Almond, oil                        0.050000   1.000  1.000
 

14000041 14   Almond, oil-babyfood               0.050000   1.000  1.000
 

14002690 14   Pecan                              0.050000   1.000  1.000
 

15004010 15   Wheat, grain                       0.100000   1.000  1.000
 

15004011 15   Wheat, grain-babyfood              0.100000   1.000  1.000
 

15004020 15   Wheat, flour                       0.100000   1.000  1.000
 

15004021 15   Wheat, flour-babyfood              0.100000   1.000  1.000
 

15004030 15   Wheat, germ                        0.100000   1.000  1.000
 

15004040 15   Wheat, bran                        0.100000   1.000  1.000
 

21000460 M    Beef, meat byproducts              0.050000   1.000  1.000
 

21000461 M    Beef, meat byproducts-babyfood     0.050000   1.000  1.000
 

23001700 M    Goat, meat byproducts              0.050000   1.000  1.000
 

26003400 M    Sheep, meat byproducts             0.050000   1.000  1.000
 

86010000 O    Water, direct, all sources         0.024100   1.000  1.000
 

86020000 O    Water, indirect, all sources       0.024100   1.000  1.000
 

95000230 O    Banana                             0.300000   1.000  1.000
 

95000231 O    Banana-babyfood                    0.300000   1.000  1.000
 

95000240 O    Banana, dried                      0.300000   3.900  1.000
 

95000241 O    Banana, dried-babyfood             0.300000   3.900  1.000
 

95001300 O    Cranberry                          0.500000   1.000  1.000
 

95001301 O    Cranberry-babyfood                 0.500000   1.000  1.000
 

95001310 O    Cranberry, dried                   0.500000   1.000  1.000
 

95001320 O    Cranberry, juice                   0.500000   1.100  1.000
 

95001321 O    Cranberry, juice-babyfood          0.500000   1.100  1.000
 

95001750 O    Grape                              1.000000   1.000  1.000
 

95001760 O    Grape, juice                       1.000000   1.000  1.000
 

95001761 O    Grape, juice-babyfood              1.000000   1.000  1.000
 

95001770 O    Grape, leaves                      1.000000   1.000  1.000
 

95001780 O    Grape, raisin                      1.000000   4.300  1.000
 

95001790 O    Grape, wine and sherry             1.000000   1.000  1.000
 

95002630 O    Peanut                             0.100000   1.000  1.000
 

95002640 O    Peanut, butter                     0.100000   1.890  1.000
 

95002650 O    Peanut, oil                        0.100000   1.000  1.000
 

95002830 O    Plantain                           0.300000   1.000  1.000
 

95002840 O    Plantain, dried                    0.300000   3.900  1.000
 

Attachment 2:  Results of Acute Dietary Exposure Analysis

NOAEL (acute) = 30 mg/kg/day

aPAD = 0.3 mg/kg/day

DEEM-FCID Version 2.03 ACUTE Analysis for FENBUCONAZOLE  (1994-98 data)

Residue file: FenbuconAC.R98

Adjustment factor #2 NOT used.

Analysis Date: 05-30-2008/9:56:49    Residue file dated:
05-30-2008/9:53:13/8

Daily totals for food and food form consumption used.

========================================================================
======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
-------

Females 13-49 yrs: 0.009155     3.05    0.015124     5.04    0.027302   
 9.10

 

Attachment 3:  Residue Input File for Chronic (Non-Cancer) Analysis

NOAEL (chronic) = 3 mg/kg/day

cPAD = 0.03 mg/kg/day

DEEM-FCID Version 2.03

Filename: C:\Documents and Settings\ddotson\My
Documents\DEEMFCID\Fenbuconazole\FenbuconCHR.R98

Date created/last modified: 05-30-2008/9:54:03/8

Comment: RfDs are PADs and acute value is for females 13-49 only

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

01010520 1A   Beet, sugar                        0.061000   1.000  1.000
 

01010521 1A   Beet, sugar-babyfood               0.061000   1.000  1.000
 

01010530 1A   Beet, sugar, molasses              0.061000   1.800  1.000
 Empirical Factor

01010531 1A   Beet, sugar, molasses-babyfood     0.061000   1.800  1.000
 Empirical Factor

08002700 8    Pepper, bell                       0.400000   1.000  1.000
 7E7256

08002701 8    Pepper, bell-babyfood              0.400000   1.000  1.000
 7E7256

08002710 8    Pepper, bell, dried                0.400000   1.000  1.000
 7E7256

08002711 8    Pepper, bell, dried-babyfood       0.400000   1.000  1.000
 7E7256

08002720 8    Pepper, nonbell                    0.400000   1.000  1.000
 7E7256

08002721 8    Pepper, nonbell-babyfood           0.400000   1.000  1.000
 7E7256

08002730 8    Pepper, nonbell, dried             0.400000   1.000  1.000
 7E7256

10001060 10   Citrus citron                      0.073000   1.000  1.000
 Lemon Pulp 

10001070 10   Citrus hybrids                     0.073000   1.000  1.000
 Lemon Pulp

10001080 10   Citrus, oil                        0.073000  47.000  1.000
 Lemon Pulp + Emp Factor

10001800 10   Grapefruit                         0.016000   1.000  1.000
 

10001810 10   Grapefruit, juice                  0.016000   0.200  1.000
 Citrus Juice Factor

10001970 10   Kumquat                            0.073000   1.000  1.000
 

10001990 10   Lemon                              0.073000   1.000  1.000
 

10002000 10   Lemon, juice                       0.073000   0.200  1.000
 Citrus Juice Factor          

10002001 10   Lemon, juice-babyfood              0.073000   0.200  1.000
 Citrus Juice Factor          

10002010 10   Lemon, peel                        0.652000   1.000  1.000
 

10002060 10   Lime                               0.073000   1.000  1.000
 

10002070 10   Lime, juice                        0.073000   0.200  1.000
 Citrus Juice Factor 

10002071 10   Lime, juice-babyfood               0.073000   0.200  1.000
 Citrus Juice Factor 

10002400 10   Orange                             0.017000   1.000  1.000
 

10002410 10   Orange, juice                      0.017000   0.200  1.000
 Citrus Juice Factor          

10002411 10   Orange, juice-babyfood             0.017000   0.200  1.000
 Citrus Juice Factor 

10002420 10   Orange, peel                       0.652000   1.000  1.000
 

10003070 10   Pummelo                            1.000000   1.000  1.000
 

10003690 10   Tangerine                          0.073000   1.000  1.000
 Lemon Pulp 

10003700 10   Tangerine, juice                   0.073000   0.200  1.000
 Lemon Pulp + Emp Factor

11000070 11   Apple, fruit with peel             0.142000   1.000  1.000
 

11000080 11   Apple, peeled fruit                0.142000   1.000  1.000
 

11000081 11   Apple, peeled fruit-babyfood       0.142000   1.000  1.000
 

11000090 11   Apple, dried                       0.142000   8.000  1.000
 Default Proc Factor

11000091 11   Apple, dried-babyfood              0.142000   8.000  1.000
 Default Proc Factor 

11000100 11   Apple, juice                       0.142000   0.059  1.000
 Empirical Factor

11000101 11   Apple, juice-babyfood              0.142000   0.059  1.000
 Empirical Factor

11000110 11   Apple, sauce                       0.142000   1.000  1.000
 

11000111 11   Apple, sauce-babyfood              0.142000   1.000  1.000
 

12000120 12   Apricot                            0.307000   1.000  1.000
 Average Peach Value

12000121 12   Apricot-babyfood                   0.307000   1.000  1.000
 

12000130 12   Apricot, dried                     0.307000   6.000  1.000
 Default Factor

12000140 12   Apricot, juice                     0.307000   1.000  1.000
 

12000141 12   Apricot, juice-babyfood            0.307000   1.000  1.000
 

12000900 12   Cherry                             0.336000   1.000  1.000
 

12000901 12   Cherry-babyfood                    0.336000   1.000  1.000
 

12000910 12   Cherry, juice                      0.336000   1.000  1.000
 

12000911 12   Cherry, juice-babyfood             0.336000   1.000  1.000
 

12002300 12   Nectarine                          0.307000   1.000  1.000
 

12002600 12   Peach                              0.307000   1.000  1.000
 

12002601 12   Peach-babyfood                     0.307000   1.000  1.000
 

12002610 12   Peach, dried                       0.307000   7.000  1.000
 Default Proc Factor  

12002611 12   Peach, dried-babyfood              0.307000   7.000  1.000
 Default Proc Factor

12002620 12   Peach, juice                       0.307000   1.000  1.000
 

12002621 12   Peach, juice-babyfood              0.307000   1.000  1.000
 

12002850 12   Plum                               0.063000   1.000  1.000
 

12002851 12   Plum-babyfood                      0.063000   1.000  1.000
 

12002860 12   Plum, prune, fresh                 0.063000   1.000  1.000
 

12002861 12   Plum, prune, fresh-babyfood        0.063000   1.000  1.000
 

12002870 12   Plum, prune, dried                 0.063000   3.400  1.000
 Empirical Factor

12002871 12   Plum, prune, dried-babyfood        0.063000   3.400  1.000
 Empirical Factor

12002880 12   Plum, prune, juice                 0.063000   1.000  1.000
 

12002881 12   Plum, prune, juice-babyfood        0.063000   1.000  1.000
 

13020570 13B  Blueberry                          0.300000   1.000  1.000
 

13020571 13B  Blueberry-babyfood                 0.300000   1.000  1.000
 

13021360 13B  Currant                            0.093000   1.000  1.000
 

13021370 13B  Currant, dried                     0.093000   1.000  1.000
 

13021490 13B  Elderberry                         0.093000   1.000  1.000
 

13021740 13B  Gooseberry                         0.093000   1.000  1.000
 

13021910 13B  Huckleberry                        0.093000   1.000  1.000
 

14000030 14   Almond                             0.015000   1.000  1.000
 

14000031 14   Almond-babyfood                    0.015000   1.000  1.000
 

14000040 14   Almond, oil                        0.015000   1.000  1.000
 

14000041 14   Almond, oil-babyfood               0.015000   1.000  1.000
 

14002690 14   Pecan                              0.015000   1.000  1.000
 

15004010 15   Wheat, grain                       0.017000   1.000  1.000
 

15004011 15   Wheat, grain-babyfood              0.017000   1.000  1.000
 

15004020 15   Wheat, flour                       0.017000   0.150  1.000
 Empirical Factor

15004021 15   Wheat, flour-babyfood              0.017000   0.150  1.000
 Empirical Factor

15004030 15   Wheat, germ                        0.017000   0.850  1.000
 Empirical Factor

15004040 15   Wheat, bran                        0.017000   1.400  1.000
 Empirical Factor

21000460 M    Beef, meat byproducts              0.050000   1.000  1.000
 

21000461 M    Beef, meat byproducts-babyfood     0.050000   1.000  1.000
 

23001700 M    Goat, meat byproducts              0.050000   1.000  1.000
 

26003400 M    Sheep, meat byproducts             0.050000   1.000  1.000
 

95000230 O    Banana                             0.028000   1.000  1.000
 

95000231 O    Banana-babyfood                    0.028000   1.000  1.000
 

95000240 O    Banana, dried                      0.028000   3.900  1.000
 Default Factor

95000241 O    Banana, dried-babyfood             0.028000   3.900  1.000
 Default Factor

95001300 O    Cranberry                          0.199000   1.000  1.000
 

95001301 O    Cranberry-babyfood                 0.199000   1.000  1.000
 

95001310 O    Cranberry, dried                   0.199000   1.000  1.000
 

95001320 O    Cranberry, juice                   0.199000   1.100  1.000
 

95001321 O    Cranberry, juice-babyfood          0.199000   1.100  1.000
 

95001750 O    Grape                              0.390000   1.000  1.000
 

95001760 O    Grape, juice                       0.390000   0.180  1.000
 Empirical Factor

95001761 O    Grape, juice-babyfood              0.390000   0.180  1.000
 Empirical Factor

95001770 O    Grape, leaves                      0.390000   1.000  1.000
 

95001780 O    Grape, raisin                      0.390000   4.300  1.000
 

95001790 O    Grape, wine and sherry             0.390000   0.700  1.000
 Empirical Factor

95002630 O    Peanut                             0.035000   1.000  1.000
 

95002640 O    Peanut, butter                     0.035000   1.890  1.000
 

95002650 O    Peanut, oil                        0.035000   1.000  1.000
 

95002830 O    Plantain                           0.028000   1.000  1.000
 

95002840 O    Plantain, dried                    0.028000   3.900  1.000
 

86010000 O    Water, direct, all sources         0.016500   1.000  1.000
 1 in 10 Year Annual Avg

86020000 O    Water, indirect, all sources       0.016500   1.000  1.000
 1 in 10 Year Annual Avg

Attachment 4:  Results of Chronic Dietary Exposure Analysis

NOAEL (Chronic) = 3 mg/kg/day

cPAD = 0.03 mg/kg/day

Residue file name: C:\Documents and Settings\ddotson\My
Documents\DEEMFCID\Fenbuconazole\FenbuconCHR.R98

Adjustment factor #2 NOT used.

Analysis Date 05-30-2008/9:59:11

Residue file dated: 05-30-2008/9:54:03/8

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.000700                
2.3%

U.S. Population (spring season)             0.000689                
2.3%

U.S. Population (summer season)             0.000754                
2.5%

U.S. Population (autumn season)             0.000678                
2.3%

U.S. Population (winter season)             0.000681                
2.3%

Northeast region                            0.000701                
2.3%

Midwest region                              0.000706                
2.4%

Southern region                             0.000624                
2.1%

Western region                              0.000815                
2.7%

Hispanics                                   0.000743                
2.5%

Non-hispanic whites                         0.000708                
2.4%

Non-hispanic blacks                         0.000599                
2.0%

Non-hisp/non-white/non-black                0.000762                
2.5%

All infants (< 1 year)                      0.002027                
6.8%

Nursing infants                             0.000982                
3.3%

Non-nursing infants                         0.002424                
8.1%

Children 1-6  yrs                           0.001521                
5.1%

Children 7-12 yrs                           0.000762                
2.5%

Females 13-19 (not preg or nursing)         0.000438                
1.5%

Females 20+ (not preg or nursing)           0.000629                
2.1%

Females 13-50 yrs                           0.000606                
2.0%

Females 13+ (preg/not nursing)              0.000636                
2.1%

Females 13+ (nursing)                       0.000797                
2.7%

Males 13-19 yrs                             0.000441                
1.5%

Males 20+ yrs                               0.000551                
1.8%

Seniors 55+                                 0.000655                
2.2%

Children 1-2 yrs                            0.001842                
6.1%

Children 3-5 yrs                            0.001450                
4.8%

Children 6-12 yrs                           0.000812                
2.7%

Youth 13-19 yrs                             0.000440                
1.5%

Adults 20-49 yrs                            0.000563                
1.9%

Adults 50+ yrs                              0.000645                
2.2%

Females 13-49 yrs                           0.000572                
1.9%

Attachment 5:  Residue Input File for Cancer Analysis

DEEM-FCID Version 2.03

Filename: C:\Documents and Settings\ddotson\My
Documents\DEEMFCID\Fenbuconazole\FenbuconCANCER.R98

Date created/last modified: 05-30-2008/9:55:05/8

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

01010520 1A   Beet, sugar                        0.061000   1.000  1.000
 

01010521 1A   Beet, sugar-babyfood               0.061000   1.000  1.000
 

01010530 1A   Beet, sugar, molasses              0.061000   1.800  1.000
 Empirical Factor

01010531 1A   Beet, sugar, molasses-babyfood     0.061000   1.800  1.000
 Empirical Factor

08002700 8    Pepper, bell                       0.400000   1.000  1.000
 7E7256

08002701 8    Pepper, bell-babyfood              0.400000   1.000  1.000
 7E7256

08002710 8    Pepper, bell, dried                0.400000   1.000  1.000
 7E7256

08002711 8    Pepper, bell, dried-babyfood       0.400000   1.000  1.000
 7E7256

08002720 8    Pepper, nonbell                    0.400000   1.000  1.000
 7E7256

08002721 8    Pepper, nonbell-babyfood           0.400000   1.000  1.000
 7E7256

08002730 8    Pepper, nonbell, dried             0.400000   1.000  1.000
 7E7256

10001060 10   Citrus citron                      0.073000   1.000  1.000
 Lemon Pulp 

10001070 10   Citrus hybrids                     0.073000   1.000  1.000
 Lemon Pulp

10001080 10   Citrus, oil                        0.073000  47.000  1.000
 Lemon Pulp + Emp Factor

10001800 10   Grapefruit                         0.016000   1.000  0.400
 

10001810 10   Grapefruit, juice                  0.016000   0.200  0.400
 Citrus Juice Factor

10001970 10   Kumquat                            0.073000   1.000  1.000
 

10001990 10   Lemon                              0.073000   1.000  1.000
 

10002000 10   Lemon, juice                       0.073000   0.200  1.000
 Citrus Juice Factor          

10002001 10   Lemon, juice-babyfood              0.073000   0.200  1.000
 Citrus Juice Factor          

10002010 10   Lemon, peel                        0.652000   1.000  1.000
 

10002060 10   Lime                               0.073000   1.000  1.000
 

10002070 10   Lime, juice                        0.073000   0.200  1.000
 Citrus Juice Factor 

10002071 10   Lime, juice-babyfood               0.073000   0.200  1.000
 Citrus Juice Factor 

10002400 10   Orange                             0.017000   1.000  0.010
 

10002410 10   Orange, juice                      0.017000   0.200  0.010
 Citrus Juice Factor          

10002411 10   Orange, juice-babyfood             0.017000   0.200  0.010
 Citrus Juice Factor 

10002420 10   Orange, peel                       0.652000   1.000  0.010
 

10003070 10   Pummelo                            1.000000   1.000  1.000
 

10003690 10   Tangerine                          0.073000   1.000  0.010
 Lemon Pulp 

10003700 10   Tangerine, juice                   0.073000   0.200  0.010
 Lemon Pulp + Emp Factor

11000070 11   Apple, fruit with peel             0.142000   1.000  0.010
 

11000080 11   Apple, peeled fruit                0.142000   1.000  0.010
 

11000081 11   Apple, peeled fruit-babyfood       0.142000   1.000  0.010
 

11000090 11   Apple, dried                       0.142000   8.000  0.010
 Default Proc Factor

11000091 11   Apple, dried-babyfood              0.142000   8.000  0.010
 Default Proc Factor 

11000100 11   Apple, juice                       0.142000   0.059  0.010
 Empirical Factor

11000101 11   Apple, juice-babyfood              0.142000   0.059  0.010
 Empirical Factor

11000110 11   Apple, sauce                       0.142000   1.000  0.010
 

11000111 11   Apple, sauce-babyfood              0.142000   1.000  0.010
 

12000120 12   Apricot                            0.307000   1.000  0.100
 Average Peach Value

12000121 12   Apricot-babyfood                   0.307000   1.000  0.100
 

12000130 12   Apricot, dried                     0.307000   6.000  0.100
 Default Factor

12000140 12   Apricot, juice                     0.307000   1.000  0.100
 

12000141 12   Apricot, juice-babyfood            0.307000   1.000  0.100
 

12000900 12   Cherry                             0.336000   1.000  0.200
 

12000901 12   Cherry-babyfood                    0.336000   1.000  0.200
 

12000910 12   Cherry, juice                      0.336000   1.000  0.200
 

12000911 12   Cherry, juice-babyfood             0.336000   1.000  0.200
 

12002300 12   Nectarine                          0.307000   1.000  0.100
 

12002600 12   Peach                              0.307000   1.000  0.150
 

12002601 12   Peach-babyfood                     0.307000   1.000  0.150
 

12002610 12   Peach, dried                       0.307000   7.000  0.150
 Default Proc Factor  

12002611 12   Peach, dried-babyfood              0.307000   7.000  0.150
 Default Proc Factor

12002620 12   Peach, juice                       0.307000   1.000  0.150
 

12002621 12   Peach, juice-babyfood              0.307000   1.000  0.150
 

12002850 12   Plum                               0.063000   1.000  1.000
 

12002851 12   Plum-babyfood                      0.063000   1.000  1.000
 

12002860 12   Plum, prune, fresh                 0.063000   1.000  0.010
 

12002861 12   Plum, prune, fresh-babyfood        0.063000   1.000  0.010
 

12002870 12   Plum, prune, dried                 0.063000   3.400  0.010
 Empirical Factor

12002871 12   Plum, prune, dried-babyfood        0.063000   3.400  0.010
 Empirical Factor

12002880 12   Plum, prune, juice                 0.063000   1.000  0.010
 

12002881 12   Plum, prune, juice-babyfood        0.063000   1.000  0.010
 

13020570 13B  Blueberry                          0.300000   1.000  0.400
 

13020571 13B  Blueberry-babyfood                 0.300000   1.000  0.400
 

13021360 13B  Currant                            0.093000   1.000  1.000
 

13021370 13B  Currant, dried                     0.093000   1.000  1.000
 

13021490 13B  Elderberry                         0.093000   1.000  1.000
 

13021740 13B  Gooseberry                         0.093000   1.000  1.000
 

13021910 13B  Huckleberry                        0.093000   1.000  1.000
 

14000030 14   Almond                             0.015000   1.000  1.000
 

14000031 14   Almond-babyfood                    0.015000   1.000  1.000
 

14000040 14   Almond, oil                        0.015000   1.000  1.000
 

14000041 14   Almond, oil-babyfood               0.015000   1.000  1.000
 

14002690 14   Pecan                              0.015000   1.000  0.150
 

15004010 15   Wheat, grain                       0.017000   1.000  1.000
 

15004011 15   Wheat, grain-babyfood              0.017000   1.000  1.000
 

15004020 15   Wheat, flour                       0.017000   0.150  1.000
 Empirical Factor

15004021 15   Wheat, flour-babyfood              0.017000   0.150  1.000
 Empirical Factor

15004030 15   Wheat, germ                        0.017000   0.850  1.000
 Empirical Factor

15004040 15   Wheat, bran                        0.017000   1.400  1.000
 Empirical Factor

21000460 M    Beef, meat byproducts              0.050000   1.000  1.000
 

21000461 M    Beef, meat byproducts-babyfood     0.050000   1.000  1.000
 

23001700 M    Goat, meat byproducts              0.050000   1.000  1.000
 

26003400 M    Sheep, meat byproducts             0.050000   1.000  1.000
 

95000230 O    Banana                             0.028000   1.000  1.000
 

95000231 O    Banana-babyfood                    0.028000   1.000  1.000
 

95000240 O    Banana, dried                      0.028000   3.900  1.000
 Default Factor

95000241 O    Banana, dried-babyfood             0.028000   3.900  1.000
 Default Factor

95001300 O    Cranberry                          0.199000   1.000  1.000
 

95001301 O    Cranberry-babyfood                 0.199000   1.000  1.000
 

95001310 O    Cranberry, dried                   0.199000   1.000  1.000
 

95001320 O    Cranberry, juice                   0.199000   1.100  1.000
 

95001321 O    Cranberry, juice-babyfood          0.199000   1.100  1.000
 

95001750 O    Grape                              0.390000   1.000  1.000
 

95001760 O    Grape, juice                       0.390000   0.180  1.000
 Empirical Factor

95001761 O    Grape, juice-babyfood              0.390000   0.180  1.000
 Empirical Factor

95001770 O    Grape, leaves                      0.390000   1.000  1.000
 

95001780 O    Grape, raisin                      0.390000   4.300  1.000
 

95001790 O    Grape, wine and sherry             0.390000   0.700  1.000
 Empirical Factor

95002630 O    Peanut                             0.035000   1.000  1.000
 

95002640 O    Peanut, butter                     0.035000   1.890  1.000
 

95002650 O    Peanut, oil                        0.035000   1.000  1.000
 

95002830 O    Plantain                           0.028000   1.000  1.000
 

95002840 O    Plantain, dried                    0.028000   3.900  1.000
 

86010000 O    Water, direct, all sources         0.011700   1.000  1.000
 30-Year Annual Average

86020000 O    Water, indirect, all sources       0.011700   1.000  1.000
 30-Year Annual Average

Attachment 6:  Results of Cancer Dietary Exposure Analysis

NOAEL (Chronic) = 3 mg/kg/day

cPAD = 0.03 mg/kg/day

Q* = 0.00359 (mg/kg/day)-1

Residue file name: C:\Documents and Settings\ddotson\My
Documents\DEEMFCID\Fenbuconazole\FenbuconCANCER.R98

Adjustment factor #2 used.

Analysis Date 05-30-2008/10:03:14     Residue file dated:
05-30-2008/9:55:05/8

========================================================================
======

                    Total exposure by population subgroup

------------------------------------------------------------------------
------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.000473                
1.6%

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Attachment 7:  Screening Level Usage Analysis (SLUA)

May 13, 2008

Screening Level Estimates of Agricultural Uses of FENBUCONAZOLE 129011

Sorted Alphabetically

	Crop	Lbs. A.I.	Percent Crop Treated

	Average	Maximum

1	Apples	<500	<1	<2.5

2	Apricots	<500	10	20

3	Blueberries	3,000	40	50

4	Cherries	5,000	20	25

5	Grapefruit	8,000	40	50

6	Nectarines	1,000	10	20

7	Oranges	2,000	<1	5

8	Peaches	5,000	15	25

9	Pears	<500	<1	<2.5

10	Pecans	20,000	15	20

11	Prunes	<500	<1	<2.5

12	Tangerines	<500	<1	<2.5

13	Walnuts	<500	<1	<2.5

All numbers rounded

<500 indicates less than 500 pounds of active ingredient

<2.5 indicates less than 2.5 percent of crop is treated

<1 indicates less than 1 percent of crop is treated

SLUA Data Sources Include:

USDA-NASS (United States Department of Agriculture’s National
Agricultural Statistics Service);  2001-2006

Private Pesticide Market Research, 2001-2006

NPUD 2002 (National Pesticide Use Database) of the CropLife America
Foundation and California DPR data

These results reflect amalgamated data developed by the Agency and are
releasable to the public.

Fenbuconazole	Dietary Exposure and Risk Assessment	DP Number: 350321	

PC Code:  129011		

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