Document ID: EPA-HQ-OPP-2008-0271-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2009-07-14T04:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF              

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES 

MEMORANDUM

DATE:  	February 18, 2009

SUBJECT:	Revised Indoxacarb Acute and Chronic Aggregate Dietary (Food
and Drinking Water) Exposure and Risk Assessment for the Section 3
Registration Action. 

	

PC Code: 067710	DP Barcode:   D360559

Decision No.: 390597	Registration No.: 352-597

Petition No.: 8E7324	Regulatory Action: Section3

Risk Assessment Type: Single Chemical /Aggregate	Case No.: NA

TXR No.: NA	CAS No.: 173584-44-6

MRID No.: NA	40 CFR:180.564

REVIEWER:	Seyed Tadayon, Chemist

Risk Assessment Branch V

Health Effects Division (7509P)

THROUGH:	Doug Dotson, Ph.D., Chemist

				Thurston Morton, Chemist

	Dietary Exposure Science Advisory Council (DE SAC)

TO:		Danette Drew, Chemist

Risk Assessment Branch V

Health Effects Division (7509P)

This is a revision of the  Acute and Chronic Aggregate Dietary (Food and
Drinking Water) Exposure and Risk Assessment, (S. Tadayon November 28,
2008, D356924) for Indoxacarb.  This document has been revised to
address changes proposed on PODs for Indoxacarb mixture (KN127 and KN128
isomers).

Executive Summary

Acute and chronic dietary risk assessments for indoxacarb were conducted
using the Dietary Exposure Evaluation Model DEEM-FCID(, Version 2.03, 
which uses food consumption data from the USDA’s Continuing Surveys of
Food Intakes by Individuals (CSFII) from 1994-1996 and 1998.  The
analyses were performed to support Section 3 registrations on garden
beets and the blueberry subgroup 13-07B.  

The last dietary risk assessment for indoxacarb was conducted on
28-Nov-2008 (Memo, S. TadayonSahafeyan; DP#: 356924).  

Refined acute probabilistic and chronic dietary exposure assessments
were conducted for all existing and proposed new food uses of
indoxacarb.  A cancer dietary exposure assessment was not conducted for
indoxacarb, because indoxacarb has been classified as “not likely to
be carcinogenic.”  Estimated drinking water concentrations (EDWCs),
provided by the Environmental Fate and Effects Division (EFED), were
included in the current assessments as well.  Anticipated residues (ARs)
for all registered and proposed food commodities were based on field
trial data (FTD).  ARs for all current uses were further refined using
percent crop treated (%CT) data (Memo, A. Halvorson, 05-APR-2007; DP#:
338731) following the guidance provided in HED Standard Operating
Procedure (SOP) 99.6 (Classification of Food Forms with Respect to level
of Blending; 20-AUG-1999).  100% CT was assumed for the new uses. 
Available processing data for indoxacarb were used to refine ARs for
apples/pears (juice), potato (dry, chips), cotton (oil), tomato (paste
and puree), peanut (oil), soybean (oil), grapes (raisin and juice),
prunes (dried), and mint (oil), and other commodities where translation
was applicable.  For all other processed commodities, DEEM-FCID( (ver.
7.81) default processing factors (PFs) were assumed.

EDWCs were provided by EFED (Memo, J. Lin, 09-JUL-2008; DP#: 351088) and
incorporated directly into the DEEM-FCID( analyses.  Both the acute and
chronic analyses were conducted using estimated surface water residues
generated using the Pesticide Root Zone/Exposure Analysis Modeling
System (PRZM/EXAMS).  EFED provided modeling results for several crop
scenarios.  

Acute Dietary Exposure Results

  

Estimated acute dietary exposure to indoxacarb from food and drinking
water is below HED’s level of concern for all population subgroups. 
Combined dietary exposure from food and drinking water at the 99.9th
percentile of exposure is estimated to be 0.034659 mg/kg/day for the
overall U.S. population equivalent to 29% of the aPAD.  The population
subgroup with the highest estimated acute dietary exposure to indoxacarb
is children, 3 to 5 years old, with an estimated exposure at the 99.9th
percentile of 0.07614 mg/kg/day, equivalent to 64% of the aPAD.  An
acute dietary endpoint was not identified foe females 13-49.  As a
result HED did not determine acute exposure and risk estimates for this
population subgroup.

Chronic Dietary Exposure Results

Estimated chronic dietary exposure to indoxacarb from food and drinking
water is below HED’s level of concern.  Combined dietary exposure from
food and drinking water is estimated at 0.002465 mg/kg/day for the
general U.S. population (12 % of the chronic population-adjusted dose
(cPAD)) and 0.007884 mg/kg/day (39 % of the cPAD) for children, 1 to 2
years old, the population subgroup with the highest estimated chronic
dietary exposure to indoxacarb.

I.	Introduction

	Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population adjusted dose
(PAD).  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL,
e.g.) divided by the required uncertainty or safety factors.

	For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  References which
discuss the acute and chronic risk assessments in more detail are
available on the EPA/pesticides web site:  “Available Information on
Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web
link:  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf.

II.	Residue Information

	Tolerances for the combined residues of indoxacarb + its R-enantiomer
are published in 40 CFR §180.564.  There are currently two end-use
products of indoxacarb with food/feed uses registered to DuPont:  a 30%
water-dispersible granular (WDG) formulation (DuPont Avaunt(
Insecticide, EPA Reg. No. 352-597) and a 1.25 lb/gal (15%) suspension
concentrate (SC) formulation (DuPont Steward® Insecticide, EPA Reg. No.
352-598).  These formulations contain an isomeric mixture of 75%
indoxacarb (insecticidally active S-enantiomer; DPX-KN128) and 25% of
the R-enantiomer (insecticidally inactive; IN-KN127).  The percentage of
active ingredient (a.i.) listed on each label and the labeled use rates
for each crop are based only on the amount of indoxacarb.  

Residues of Concern:  The nature of the residue in plants and livestock
is adequately understood.  Data from the plant and ruminant metabolism
studies, as well as toxicological and environmental fate data were
presented to the HED Metabolism Assessment Review Committee (MARC) for
determination of the residues of concern (Memo, S. Levy, 10-JUL-2000;
DP#: 263986).  See DP#: 324855 for the chemical structures of indoxacarb
and its metabolites.

Tolerances:  Permanent tolerances have been established under 40 CFR
§180.564(a) for the combined residues of indoxacarb + its R-enantiomer
as follows:  apple (1.0 ppm); apple, wet pomace (3.0 ppm); Brassica,
head and stem, subgroup 5A (5.0 ppm); alfalfa, forage (10 ppm); alfalfa,
hay (50 ppm); corn, sweet, forage (10 ppm); corn, sweet, kernel plus cob
with husk removed (0.02 ppm); corn, sweet, stover (15 ppm); cotton gin
byproducts (15 ppm); cotton, undelinted seed (2.0 ppm); lettuce, head
(5.0 ppm); lettuce, leaf (10 ppm); pear (0.20 ppm); peanut (0.01 ppm);
peanut, hay (40 ppm); potato (0.01 ppm); soybean, aspirated grain
fractions (45 ppm); soybean, hulls (4.0 ppm); soybean, seed (0.80 ppm);
vegetables, fruiting, group 8 (0.50 ppm); milk (0.15 ppm); milk fat (4.0
ppm); and in fat (1.5 ppm); meat (0.05 ppm); and meat-byproducts (0.03
ppm) of cattle, goat, hog, horse, and sheep.   

Dupont and Interregional Research Project No. 4 (IR-4) have proposed
tolerances for Indoxacarb on garden beets and blueberries (subgroup
13-7B).  The proposed tolerances are summarized below in Table 1
together with HED’s recommendations based on review of the residue
data submitted to support these petitions (P.Savoia, 28-NOV 2008).

Table 1 Tolerance Summary for proposed uses of Indoxacarb

Crop Commodity	Proposed or Established Tolerance (ppm)	Recommended
Tolerance  ppm)	Comments

Beet, garden, roots	0.3	0.3	Adequate data are available

Beets, garden, tops	6.0	6.0	Adequate data are available

Blueberry, subgroup 13-7B	1.5	1.5	Adequate data are available

Residue Data used for the Acute and Chronic Assessments:  

Food Commodities (except livestock commodities):  Refined acute
probabilistic and chronic dietary exposure assessments were conducted
for all existing and proposed new food uses of indoxacarb and drinking
water.  ARs for all registered and proposed food commodities were based
on FTD.  When a commodity had a number of <LOQ residue values, either
the highest FTD or tolerance was used for ease of calculation (i.e., for
apples, the corrected highest field trial value was used for the
“treated” commodity, instead of constructing a RDF with the full
distribution of corrected values).  ARs for all current uses were
further refined using %CT data, following the guidance provided in HED
SOP 99.6 (Classification of Food Forms with Respect to level of
Blending; 20-AUG-1999).  100% CT was assumed for the remaining new uses.
 Available processing data were used to refine ARs for apples/pears
(juice), potato (dry, chips), cotton (oil), tomato (paste and puree),
peanut (oil), soybean (oil), grapes (raisin and juice), prunes (dried),
and mint (oil), and commodities were translated as appropriate.  For all
other processed commodities, DEEM-FCID( (ver. 7.81) default PFs were
assumed.

IndoxacarbUse

Indoxacarb is an oxadiazine insecticide (Group 22) used for control of
lepidopteran pests on a variety of fruit, vegetable and field crops. 
Permanent tolerances are established for the combined residues of
indoxacarb, (S)-methyl
7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoro
methoxy)phenyl]amino]carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carb
oxylate, and its inactive R-enantiomer in/on various plant commodities
at levels ranging from 0.01 ppm in/on tuberous and corm vegetables and
peanuts to 50 ppm in/on alfalfa hay [40 CFR §180.564(a)].  

Residue Data used for the Acute and Chronic Assessments:  

Acute Assessment:

For non-blended and partially blended commodities:  A
residue-distribution file (RDF) was constructed using the entire
distribution of field trial residue values, with zeros incorporated to
account for the untreated portion of the crop (untreated portion = 100%
minus the estimated maximum %CT).  The resulting residue distributions
were used probabilistically in the acute assessment.  All PFs were
inserted in DEEM-FCID( under “adjustment factor 1.”

For blended commodities:  A point estimate was calculated by taking the
average field trial residue and adjusting it by the maximum %CT estimate
(point estimate = average residue x maximum %CT).  All PFs were inserted
in DEEM-FCID( under “adjustment factor 1.”

Chronic Assessment:

For non-blended, partially blended and blended commodities:  A point
estimate was calculated by taking the average field trial value and
adjusting it by the average %CT estimate (Point estimate = average
residue x average %CT).  All PFs were inserted in DEEM-FCID( under
“adjustment factor 1.”

Livestock commodities:  For poultry, egg and milk, since the residues of
concern were different than the tolerance expression, the metabolism
study, in conjunction with feeding studies was used to calculate the
secondary residues in those tissues (see detail discussion later in this
section).  For ruminant and hog tissues, since the tolerance expression
was the same as the residues of concern, the tolerance values were used
as conservative estimates of the indoxacarb residues.

The food residue data used in the acute and chronic dietary assessments
are summarized in Table 2.  RDFs used in the acute assessment are
included in the attachments to this document.

Table 2.  Data and Residue Estimates Used in the Acute and Chronic
Dietary Analyses

Commodity	Classification	ave.

% CT	Max

% CT	Source of Data	# of FTD	# of zeroes in RDF	sum (FTD)	mean of RDF	PF
Acute Value	Chronic

Value

apple juice	PB	1	5	highest FTD (DP#:  244253)	5	95	3.7	0.037	0.01	rdf x
PF	0.0074 x PF

apples	NB	1	5	highest FTD (DP#: 244253)	5	95	3.7	0.037

rdf	0.0074

apples, dried	B	1	5	highest FTD (DP#: 244253)	5	95	3.7	0.037	8	0.037 x
PF	0.0074 x PF

Apricot	PB	100	100	peach FTD (DP#: 325479)	30	0	4.66	0.155

rdf	0.155

Apricot, dried	B	100	100	FTD

 (DP#: 325479)	30	0	4.66	0.155	6	0.155 x PF	0.155 x PF

Beet Garden Roots

100	100	351087	10

0.16

Beet Garden Tops

100	100	351087	10

2.47

Blueberry

100	100	351087	26

0.57

Broccoli	NB	40	50	FTD 

(DP#: 244253)	20	20	12.95	0.3238

rdf	0.259

`Cabbage

(no wrapper)	NB	15	25	FTD 

(DP#: 244253)	22	66	1.27	0.0144

rdf	0.0087

Cantaloupe	NB	100	100	FTD 

(DP#: 325479)	22	0	2.236	0.1016

rdf	0.1016

Cauliflower	NB	35	55	broccoli FTD	20	16	12.95	0.3561

rdf	0.2266

Celery-untrimmed	PB	100	100	FTD

 (DP#: 325479)	12	0	23.2	1.9333

rdf	1.93

Cherry	PB	1	2.5	FTD

 (DP#: 325479)	32	1248	8	0.0063

rdf	0.0025

Cherry juice	PB	1	2.5	FTD 

(DP#: 325479)	32	1248	8	0.0063	1.5	rdf x PF	0.0025 x PF

Corn, sweet	NB	1	2.5	highest FTD (DP#: 244253)	1	39	0.008	0.0002

rdf	0.00008

Cottonseed oil	B	100	100	highest FTD (DP#: 244253)	1	0	0.67	0.67	0.04
0.67 x PF	0.67 x PF

Cranberry	PB	100	100	FTD 

(DP#: 325479)	12	0	2.591	0.2159

rdf	0.2160

Cucumber	NB	100	100	FTD 

(DP#: 325479)	20	0	0.459	0.0230

rdf	0.023

Eggs	NB	100	100	see text	1	0	0.119	0.119

0.119	0.119

Group 8, the rest (okra, eggplant, tomatillo)	PB	100	100	highest tomato
FTD 

(DP#: 244253)	1	0	0.27	0.27

0.27	0.27

Grape	PB	100	100	FTD 

(DP#: 290126)	20	0	10.06	0.5030

rdf	0.503

Grape juice/wine	PB	100	100	FTD 

(DP#: 290126)	20	0	10.06	0.5030	0.007	rdf x PF	0.503 x PF

Grape leaves	PB	100	100	FTD 

(DP#: 290126)	20	0	10.06	0.5030

rdf	0.503

Grape raisins	PB	100	100	FTD

(DP#: 290126)	20	0	10.06	0.5030	2.7	rdf x PF	0.5030 x PF

Group 11, except apples and pears	NB	100	100	highest FTD for apples

(DP#: 244253)	1	0	0.74	0.7400

0.74	0.74

Lettuce head, no wrapper	NB	18	25

18	54	3.97	0.0551

rdf	0.0397

Lettuce, leaf	NB	9	11	DP#: 244253	18	146	108.2	0.6612

rdf	0.541

Milk fat	PB	100	100	see text	1	0	3.28	3.28

2.43	2.43

Milk water	PB	100	100	see text	1	0	0.11	0.11

0	0

Milk, non-fat solids	PB	100	100	see text	1	0	0.29	0.29

0.495	0.495

Mint	B	100	100	FTD 

(DP#: 325479)	12	0	46.44	3.8700

3.8700	3.87

Mint oil	B	100	100

12	0	46.44	3.8700	0.028	3.87 x PF	3.87 x PF

Mustard Green	PB	100	100	FTD 

(DP#: 325479)	8	0	47.8	5.9750

rdf	5.975

Nectarine	PB	100	100	Peach FTD (DP#: 325479)	30	0	4.66	0.1553

rdf	0.1553

Peach 	NB	1	2.5	FTD 

(DP#: 325479)	30	1170	4.66	0.0039

rdf	0.0016

Peach Dried	B	1	2.5	FTD 

(DP#: 325479)	30	1170	4.66	0.0039	4	0.0039 x PF	0.0016

Peanut	B	1	2.5	highest FTD (DP#: 244253)	1	39	0.003	0.000075

0.000075	0.00003

Peanut butter	B	1	2.5	highest FTD (DP#: 244253)	1	39	0.003	0.000075	1.89
0.000075 x 1.89	0.00003 x1.89

Peanut oil	B	1	2.5	highest FTD (DP#: 244253)	1	39	0.003	0.000075	1.4
0.000075 x 1.4	0.00003 x 1.4

Pear	NB	1	2.5	highest FTD (DP#: 244253)	1	39	0.08	0.002

rdf	0.0008

Pear juice 	PB	1	2.5	highest FTD (DP#: 244253)	1	39	0.08	0.002	0.01	rdf
x PF	0.0008 x PF

Pears, dried	B	1	2.5	highest FTD (DP#: 244253)	1	39	0.08	0.002	6.25
0.002 x PF	0.0008 x PF

Pepper (bell or non-bell)	PB	10	15	highest FTD (DP#: 244253)	15	85	1.005
0.0101

rdf	0.0067

Pepper, dried	B	10	15	highest FTD (DP#: 244253)	15	85	1.005	0.0101

0.0101	0.0067

Pepper, dry (bell or non-bell)	B	10	15	highest FTD (DP#: 244253)	15	85
1.005	0.0101

0.0101	0.0067

Plums-prunes	NB	100	100	FTD

(DP#: 325479)	22	0	0.99	0.0450

rdf	0.045

Plums-prunes (dried)	PB	100	100	FTD 

(DP#: 325479)	22	0	0.99	0.0450	4	0.045 x PF	0.045 x PF

Pork	NB	100	100	tolerance

tolerance	tolerance

Potato	NB	1	2.5	tolerance	1	39	0.01	0.00025

rdf	0.0001

Potato

(dry, chips)	B	1	2.5	average FTD	1	39	0.004	0.0001	0.85	0.0001 x PF
0.00004 x PF

Potato, flour	B	1	2.5	average FTD	1	39	0.004	0.0001

0.0001	0.00004

Poultry, fat	NB	100	100	see text

0.457	0.457

Poultry, liver	NB	100	100	see text

0.052	0.052

Poultry, meat	NB	100	100	see text

0.045	0.045

Poultry, meat byproduct	NB	100	100	see text

0.052	0.052

Poultry, skin	NB	100	100	see text

0.079	0.079

Ruminants	NB	100	100	tolerance

tolerance	tolerance

Southern Pea	PB	100	100	FTD 

(DP#: 325479)	14	0	0.319	0.0228

rdf	0.0228

Soybean	B	1	1	average FTD	1	99	0.088	0.00088	0.64 (for oil)	.00088 x PF
.00088 x PF

Spinach	NB	5	5	FTD 

(DP#: 325479)	16	304	84.3	0.2634

rdf	0.2634

Squash	NB	100	100	FTD 

(DP#: 325479)	22	0	0.729	0.0331

rdf	0.0331

Subgroup 1C, the rest	NB	100	100	tolerance	1	0	0.01	0.01

0.01	0.01

Subgroup 4A, the rest (not spinach & lettuce)	NB	100	100	FTD 

(DP#: 325479)	16	0	84.3	5.2688

rdf	5.2688

Subgroup 4B 	NB	100	100	Celery FTD (DP#: 325479)	12	0	23.2	1.9333

rdf	1.9333

Subgroup 5A (the rest)	PB	35	55	broccoli FTD	20	16	12.95	0.3561

rdf	0.2266

Subgroup 5B 	PB	100	100	Mustard green FTD 

(DP#: 325479)	8	0	47.8	5.9750

rdf	5.9750

Subgroup 9A, melons	NB	100	100	Cantaloupe FTD 

(DP#: 325479)	22	0	2.236	0.1016

rdf	0.1016

Subgroup 9B except cucumber	NB	100	100	summer squash FTD 

(DP#: 325479)	22	0	0.729	0.0331

rdf	0.0331

Tomatoes	PB	15	25	highest FTD (DP#: 244253)	25	75	6.75	0.0675

rdf	0.0405

Tomatoes, dried	B	15	25	highest FTD (DP#: 244253)	25	75	6.75	0.0675	14.3
0.0675 x PF	0.0405 x PF

Tomatoes, paste	B	15	25	highest FTD (DP#: 244253)	25	75	6.75	0.0675	1.4
0.0675 x PF	0.0405 x PF

Tomatoes, puree	B	15	25	highest FTD (DP#: 244253)	25	75	6.75	0.0675	0.52
0.0675 x PF	0.0405 x PF

Water (all sources)

see text

0.025	0.00537

Food Residues – Details

Vegetables, leafy, except Brassica, group 4:  The submitted field trials
for celery and spinach were conducted at different pre-harvest intervals
(PHIs) (celery at 7-, 14-, and 21-day PHIs while spinach at 3-, 7-, and
14-day PHIs).  The proposed label for leaf petiole vegetables (celery is
in subgroup 4B) lists 3-day PHI, 3-day retreatment interval (RTI),
maximum seasonal application of 0.26 lb ai/A.  Note that data are not
available for untrimmed celery at the proposed PHI of 3 days.  However,
HED used the trimmed celery residue data to estimate untrimmed celery
residues as follows:  Indoxacarb residue concentrations in trimmed and
untrimmed celery were compared for 0-day, 7-day, and 14-day PHI samples.
 Based on this comparison, trimmed to untrimmed ratios were determined
to be 2.32 for the 0-day PHI samples, 3.0 for the 7-day PHI samples and
2.3 for the 14-day PHI samples.  The average residue ratio for these
three sampling intervals was calculated to be 2.5.  The 3-day trimmed
celery residue data were entered into the MRL calculator, resulting in a
trimmed celery tolerance of 3.5 ppm.  To determine an untrimmed
tolerance value, the 3.5 ppm value was multiplied by the average trimmed
to untrimmed residue ratio of 2.5, resulting in a value of ~9.0 ppm.

Therefore, for celery, the trimmed, 3-day PHI celery FTD were multiplied
by 2.5 and were used in an RDF
(Indoxacarb-040907-3-dayPHI-UntrimdCelery.rdf).  This RDF, with
assumption of 100% CT due to unavailability of usage data for new uses,
was used for all subgroup 4B crops (leaf petiole vegetables).

On the other hand, for crop subgroup 4A (leafy greens subgroup) except
for lettuce and spinach, spinach FTD with 100% CT assumptions were used.
 For lettuce and spinach, their corresponding FTD and %CT were used in
three separate RDFs (leaf lettuce, head lettuce and spinach).  The crops
had the same use rates (4 applications, maximum use rate – 0.26 lb
ai/A, 3-day PHI).

Brassica, leafy, group 5:  Broccoli, cabbage, and mustard green FTD are
available (Memos, S. Levy, 19-JAN-2000; DP#: 244253 and 18-FEB-2005;
DP#: 290126) and were within 5x of each other, with mustard green FTD
being the highest.  The suggested use rate is the same for all crops in
this group (maximum application rate = 0.26 lb ai/A, PHI=3 days).  
Broccoli field trials were not conducted at a 1x application rate;
therefore, broccoli data were used for broccoli only after being
adjusted for rate of exaggeration (multiplied by 0.67; see DP#: 244253,
page 119) and cabbage data were used for cabbage only.  For the rest of
the crop subgroup 5A, broccoli data (higher residues than cabbage)
adjusted for zeroes with %CT for cauliflower (highest %CT in that
subgroup and in all crops), were used.  For crop subgroup 5B, mustard
green data with 100% CT were used (no %CT on any of the crops in
subgroup 5B are available).

Grape, grape juice, raisins:  Grape FTD with 100% CT assumptions were
used for grape, grape juice and raisins.  PFs (as adjustment factors in
DEEM-FCID() were also incorporated (PF for grape juice/wine and
sherry=0.007, PF for raisins=2.7).

Cucurbit Vegetables (group 9):  Cantaloupe, summer squash, and cucumber
FTD with 100% CT assumptions were used for group 9 crops.  Cantaloupe
data were used for all melons (subgroup 9A) and summer squash data
(higher than cucumber data) were utilized for all crops in subgroup 9B
except for cucumber.

Pome Fruit group (11):

Apple, apple juice, dried apple:  The highest FTD for apple which were
adjusted for rate of exaggeration (0.74 ppm) were used in an RDF.  The
RDF also incorporated zeroes according to %CT (maximum 5% and average
1%).  A PF of 0.01 was used in DEEM-FCID( as the second adjustment
factor for apple juice, and a DEEM-FCID(  default PF of 8 was used for
dried apple.  

Pear, pear juice, dried pear:  The highest FTD for pear which were
adjusted for rate of exaggeration (0.08 ppm) were used in an RDF.  The
RDF also incorporated zeroes according to %CT (maximum 2.5% and average
1%).  A PF for apple juice (0.01) was translated to pear juice as the
second adjustment factor in DEEM-FCID( as for pear juice, and a
DEEM-FCID( as default PF of 6.25 was used for dried pear.

	

For the rest of the crops in group 11, apple FTD with the same %CT were
used.

Fruit Stone, group 12:  FTD for cherries, peaches, and plums with the
same use rate were submitted; FTD residues were highest for cherries. 
The registrant requested four applications with a maximum use of 0.44 lb
ai/A and 14-day PHI.  The submitted FTD were used for the respective
crops in DEEM-FCID( as (in form of RDFs).  For other crops in group 12,
FTD for the similar fruit were used.  %CT data were only available for
cherries and peaches which were incorporated in their respective RDFs. 
For other crops in group 12, 100% CT were assumed.  An empirical PF of
4x was used for dried plums.  For the other crops in group 12, 

DEEM-FCID( default PFs were used for juice and the dried food form.

Mint:  The average of the submitted mint FTD were used as a point
estimate (assuming 100% CT) for peppermint, spearmint, and their
corresponding oil in DEEM-FCID(.  Mint and mint oil are considered
blended commodities.  An empirical PF (0.028x) was used for mint oil.

Fruiting Vegetables (group 8):  FTD were submitted for non-bell pepper,
bell pepper, and tomatoes (Memo, S. Levy, 19-JAN-1000; DP#: 244253),
with residues being highest for tomatoes.  The highest FTD residue for
both non-bell pepper and bell pepper which was adjusted for the rate
exaggeration was 0.067 ppm and that for tomato FTD was 0.27 ppm.  Two
RDFs were generated for pepper and tomatoes, using their highest FTD and
incorporating the available %CT values; the RDFs were used for
corresponding crops.  For the rest of this group (eggplant, tomatillo,
and okra), the highest FTD for tomatoes (0.27 ppm) were used, as well as
100% CT.  Empirical PFs for tomato paste (1.4x) and puree (0.52x) were
used.  The PF for tomato puree (0.52x) was also used for tomato juice. 
The DEEM-FCID( default PF for dried tomato (14.3x) was used.

Pea, southern, seed:  The submitted FTD with 100% CT assumption were
used for cowpea beans seed (per electronic communication with B.
Schneider, 10-APR-2007).  HED accepted the submitted data for dry seeds
not succulent.  As such, the FTD were used for only dry cowpea beans.

Cranberry:  The submitted FTD with assumption of 100% CT were used in an
RDF.  The DEEM-FCID( default PF for cranberry juice (1.1) was used.

Peanut, peanut butter, peanut oil:  All are considered blended
commodities.  The highest FTD for peanut (0.003 ppm) with 2.5% CT were
used to derive a point estimate for acute (0.003 X 0.025= 0.000075 ppm)
and with 1% CT for chronic (0.003 X 0.01=0.00003 ppm).  An empirical PF
of 1.4x was used for peanut oil and DEEM-FCID( default PF of 1.89x was
used for peanut butter.

Tuberous and corm vegetables, subgroup 1C: 

Potato:  For non-blended food forms, a tolerance-level residue (0.01
ppm) was used in the RDF with inserting zeroes according to %CT value. 
For blended food forms (dry potato, chips, flour), the average FTD were
used with PFs (0.85x for chips and dry potato) (Memo, S. Levy,
30-MAY-2002; DP#: 276516) inserted as adjustment factor 1 and %CT value
as adjustment factor 2 in DEEM-FCID(.

Other crops:  The tolerance level residue (0.01 ppm), with assumption of
100% CT were used for the rest of the crops in subgroup 1C.

Soybean:  Since all the soybean food forms are blended, the average FTD
(0.088 ppm) (Memo, S. Levy, 30-MAY-2002; DP#: 276516) were used as a
point estimate in conjunction with PF (0.64x for soybean oil only) as
adjustment factor 1 and %CT value as adjustment factor 2 in DEEM-FCID(.

Cottonseed oil:  The average FTD and the empirical PF (0.04x) as
adjustment factor were used.

Corn:  The highest FTD were used in an RDF incorporating zeroes
corresponding to %CT.

Livestock Commodities

Poultry- From the poultry metabolism study, the ratios of all the
metabolites of concern to those that were measured in the feeding study
were calculated to be: 1.81 for egg yolk, 2.8 for fat, 1.5 for muscle,
2.5 for liver, and 1.8 for skin (DP#: 244253).  These ratios were
multiplied by estimated measured residues in each tissue in the feeding
study to arrive at the total metabolites of concern.  The following
dietary burden in conjunction with the feed-tissue chart was used to
estimate the measured residues in each tissue.  As per HED policy,
residues in poultry tissues were not adjusted for % dry matter (DM). 
The calculated dietary burden is 2.72 ppm (electronic communication, J.
Stokes, 17-APR-2007).

Table 3.  Calculation of Poultry Dietary Burden.

Feedstuff	%DM	Classification	Tolerance	% In Diet	Dietary Burden

Corn, grain	

NA	CC4	0	70	0

Wheat, grain

CC	0	5	0

Soybean, meal1

PC5	0.8	15	0.12

Cottonseed, meal2

PC	2.0	5	0.10

Alfalfa, meal3

PC	50	5	2.50

Total

100	2.72

1   Based on soybean seed tolerance

2   Based on undelinted cottonseed tolerance

3   Based on alfalfa hay tolerance

4   CC = carbohydrate concentrate

5   PC = protein concentrate

The estimated residues of concern were used as a point estimate in
DEEM-FCID( for the corresponding poultry tissues in both acute and
chronic assessments, assuming 100% CT.  The estimated residue value in
poultry liver tissue was used for meat by-product tissues. 

Milk – From a “reasonably-balanced diet” guidelines (J. Stokes,
Revisions of Livestock Diets Percents), the following diet for dairy
cattle was made.

Table 4.  Dietary Burden for Dairy Cattle Based on Indoxacarb Proposed
Uses.  

Feedstuff	%DM	Classification	Tolerance	% In Diet	Dietary Burden

Corn, grain	88	CC	0	30	0

Wheat, grain	89	CC	0	10	0

Apple wet pomace	40	CC	3.0	5	0.38

Cottonseed, undelinted	88	PC	2.0	10	0.23

Alfalfa, forage	35	R1	10	15	4.29

Alfalfa, hay	89	R	50	30	16.85

Total

100	21.75

1   R = roughage

The calculated 21.75 ppm is anticipated to result in 0.054 ppm
indoxacarb residue in whole milk based on the feeding study (DP#:
276518, p.14) and a constructed dose-residue chart (see attachment 7). 
However, the residues of concern are indoxacarb and MP-819.  From
metabolism study (DP#: 244253, p.141), the highest ratio of metabolites
of concern to indoxacarb is 1.82; therefore, the estimated highest
residues of concern in whole milk is 0.0972 ppm.  Due to high
lipophilicity of indoxacarb (KOW = 4.65 at pH 5) those residues are
expected to be concentrated in the milk fat. Therefore, the residues in
milk fat are estimated to be at 2.43 ppm (i.e., 0.0972/4%, assuming milk
fat is 4% of whole milk).  From the same feeding study residues in cream
and skim milk were also measured; however, the fat content of the cream
is undetermined and thus, those data for cream can not be used.  The
expected indoxacarb residue in skim milk from the dose-residue chart
(see attachment 7) is 0.022 ppm; therefore, the calculated residues of
concern is 0.0396 ppm (i.e., 0.022*1.8).  With the assumption that the
residues are concentrated in non-fat solids of the skim milk (~ 8% of
the milk w/w), the estimated residues of concern in non-fat solids is
0.495 ppm (i.e., 0.0396/8%).  No residues are expected in milk water and
lactose.

Ruminants (beef, goat, sheep, horse) and Pork – Corresponding
tolerance values as point estimates (assuming 100% CT) were used for
both acute and chronic assessments. 

III.   Drinking Water Data

Reference:  Memo, J. Lin, 09-JUL-2008; DP#: 351088.

The highest indoxacarb concentrations in surface and ground source water
are associated with cotton.  This use pattern has a maximum label rate
of 0.11 lbs ai/A (0.15 lbs KN128+KN127/A).  Similar use rates are
recommended for apples, potatoes, and grapes (Draft Label for DuPont(
Avaunt®).  Tier II surface water modeling for cotton using the index
reservoir with the default percent cropped area (PCA=0.87) predicts the
1- in -10 year peak (acute) concentration of DPX-JW062 residues of 25.1
μg/L.  The 1- in -10 year annual average concentration (non-cancer
chronic) and 30-year annual average concentration (cancer) of DPX-JW062
residues are not likely to exceed 5.37 and 2.78 μg/L, respectively. 
SCI-GROW modeling indicates concentrations of DPX-JW062 are not expected
to exceed 0.21 μg/L.  The highest indoxacarb residue concentrations are
associated with the Mississippi cotton scenario (Table 5).  

For acute and chronic dietary risk assessments, the 1-in -10 year peak
(25.1 ppb) and the 1-in -10 year annual average, (5.37 ppb) indoxacarb
residues of concern in water from cotton scenario were used.

Table 5.  Default PCA Corrected PRZM/EXAMS Indoxacarb Residue
Concentrations (µg/L)

Scenario	

1- in -10 year peak	

1- in -10 year annual average	

30-year annual average

Cotton (MS)	25.068	5.373	2.782

Turf (FL)1	0.05	0.014	0.008

Apples (NC)	18.093	4.738	2.560

Cabbage (FL)	8.275	1.940	1.185

Potato (ME)	11.083	5.346	3.961

Swiss Chard (CA) Aerial Application	9.220	3.788	2.643

Swiss Chard (CA) Ground  Application	9.173	3.564	2.379

1- The default PCA correction (0.87) was not used for turf because this
use pattern was not considered in development of  PCAs.

-FCID™ Program and Consumption Information

	Indoxacarb acute and chronic dietary exposure assessments were
conducted using the DEEM-FCID™, Version 2.03, which incorporates
consumption data from USDA’s CSFII, 1994-1996 and 1998.  The 1994-96,
98 data are based on the reported consumption of more than 20,000
individuals over two non-consecutive survey days.  Foods “as
consumed” (e.g., apple pie) are linked to EPA-defined food commodities
(e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicly available recipe
translation files developed jointly by USDA/ARS and EPA.  For chronic
exposure assessment, consumption data are averaged for the entire U.S.
population and within population subgroups, but for acute exposure
assessment are retained as individual consumption events.  Based on
analysis of the 1994-96, 98 CSFII consumption data, which took into
account dietary patterns and survey respondents, HED concluded that it
is most appropriate to report risk for the following population
subgroups: the general U.S. population, all infants (<1 year old),
children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49,
females 13-49, and adults 50+ years old.

	

	For chronic dietary exposure assessments, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

	For acute exposure assessments, individual one-day food consumption
data are used on an individual-by-individual basis.  The reported
consumption amounts of each food item can be multiplied by a residue
point estimate and summed to obtain a total daily pesticide exposure for
a deterministic exposure assessment, or “matched” in multiple random
pairings with residue values and then summed in a probabilistic
assessment.  The resulting distribution of exposures is expressed as a
percentage of the aPAD on both a user (i.e., only those who reported
eating relevant commodities/food forms) and a per-capita (i.e., those
who reported eating the relevant commodities as well as those who did
not) basis.  In accordance with HED policy, per capita exposure and risk
are reported for all tiers of analysis.  However, for Tiers 1 and 2, any
significant differences in user vs. per capita exposure and risk are
specifically identified and noted in the risk assessment.

V.   Toxicological Information

Table 6 below summarizes the HED decisions on endpoints as related to
the dietary risk assessment.

Table 6.  Summary of Toxicological Doses and Endpoints for Indoxacarb
for Use in Dietary Exposure Assessment1.

Exposure

Scenario	Dose Used in Risk Assessment,

UF	FQPA SF* and Level of Concern for Risk Assessment	Study and
Toxicological Effects

	Study NOAEL	Adjusted to KN128 (100% active)

Acute Dietary

females 13-49 years of age	An endpoint of concern attributable to a
single dose was not identified.  An acute RfD was not  established.

Acute Dietary

general population including infants and children	NOAEL= 12 mg/kg

UF = 100

Acute RfD = 0.12 mg/kg	NOAEL= 9 mg/kg

UF = 100

Acute RfD = 0.09 mg/kg	FQPA SF = 1x

aPAD = 0.09 mg/kg

              (aRfD)        

         1x (FQPA SF)

= 0.09 mg/kg	acute oral rat neurotoxicity study (MP062)

LOAEL = 50 mg/kg based on decreased body weight and body-weight gain in
females.

Chronic Dietary

all populations	NOAEL= 2.0 mg/kg/day

UF = 100

Chronic RfD = 0.02 mg/kg/day	NOAEL= 1.5 mg/kg/day

UF = 100

Chronic RfD = 0.015 mg/kg/day	FQPA SF = 1x 

cPAD = 0.015mg/kg

                (cRfD)       

          1x (FQPA SF)

= 0.015 mg/kg/day	Weight of evidence approach was used from four
studies: 

1) Subchronic toxicity study- rat (MP062)

2) Subchronic neurotoxicity study - rat (MP062)	

3) Chronic/carcinogenicity study - rat (JW062)

4) Two generation rat reproduction study (JW062).

LOAEL = 3.3 mg/kg/day based on decreased body weight, body-weight gain,
food consumption and food efficiency; decreased hematocrit, hemoglobin
and red blood cells only at 6 months.

1 UF = uncertainty factor, FQPA SF = FQPA safety factor, NOAEL = no
observed adverse effect level, LOAEL = lowest observed adverse effect
level, PAD = population adjusted dose (a = acute, c = chronic) RfD =
reference dose, MP062 = 75%KN128:25%KN127 formulation; JW062 =
50%KN128:50%KN127.

VI.   Characterization of Inputs and Outputs

These analyses are considered to be partially refined dietary exposure
assessments.  In some cases, tolerance-level residues, default DEEM
processing factors, and/or 100% CT data were used.  Further refinement
to the analyses could be made through the use of ARs, incorporation of
%CT for new uses and/or monitoring data that better reflect residues at
the time of consumption.  Since both acute and chronic risk estimates
are below HED’s level of concern, more highly refined analyses are not
needed at this time. 

, 

VII.   Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned
when dietary risk exceeds 100% of the aPAD and cPAD, respectively.  The
DEEM-FCID™ analyses estimate the dietary exposure of the U.S.
population and various population subgroups.  The acute and chronic
results reported in Tables 7 and 8 are for the general U.S. population,
all infants (<1 year old), children 1-2, children 3-5, children 6-12,
youth 13-19, females 13-49, adults 20-49, and adults 50+ years.  

Acute Dietary Exposure Results

  

Estimated acute dietary exposure to indoxacarb from food and drinking
water is below HED’s level of concern for all population subgroups. 
Combined dietary exposure from food and drinking water at the 99.9th
percentile of exposure is estimated to be 0.03483 mg/kg/day for the
overall U.S. population, equivalent to 29% of the aPAD.  The population
subgroup with the highest estimated acute dietary exposure to indoxacarb
is children, 3 to 5 years old, with an estimated exposure at the 99.9th
percentile of 0.07652 mg/kg/day, equivalent to 63% of the aPAD.

Table 7.  Summary of Acute Dietary (Food + Drinking Water) Exposure and
Risk for Indoxacarb

Population Subgroup	aPAD (mg/kg/day)	95th Percentile	99th Percentile
99.9th Percentile

Exposure (mg/kg/day)	% aPAD	Exposure (mg/kg/day)	% aPAD	Exposure
(mg/kg/day)	% aPAD

General U.S. Population	0.12	0.007942	7	0.015191	13	0.034659	29

All Infants (< 1 year old)

0.01090	9	0.02179	18	0.03979	33

Children 1-2 years old

0.01813	15	0.02739	23	0.06974	58

Children 3-5 years old

0.01347	11	0.02201	18	0.07614	63

Children 6-12 years old

0.00877	7.3	0.01344	11	0.02943	25

Youth 13-19 years old

0.00565	5	0.01161	10	0.03955	33

Adults 20-49 years old

0.00504	4	0.00971	8	0.02726	23

Adults 50+ years old

0.004500	4	0.01304	11	0.03185	27

The population subgroup with the highest estimated acute dietary (food +
drinking water) exposure and risk is indicated by bold text.

Chronic Dietary Exposure Results

Estimated chronic dietary exposure to indoxacarb from food and drinking
water is below HED’s level of concern.  Combined dietary exposure from
food and drinking water is estimated at 0.00246 mg/kg/day for the
general U.S. population (12% of the cPAD) and 0.00788 mg/kg/day (39% of
the cPAD) for children, 1 to 2 years old, the population subgroup with
the highest estimated chronic dietary exposure to indoxacarb.

Table 8.  Summary of Chronic Dietary (Food + Drinking Water) Exposure
and Risk for Indoxacarb.

Population Subgroup	cPAD (mg/kg/day)	Exposure (mg/kg/day)	% cPAD

General U.S. Population	0.02	0.002465	12

All Infants (< 1 year old)

0.002468	12

Children 1-2 years old

0.007884	39

Children 3-5 years old

0.006041	30

Children 6-12 years old

0.003684	18

Youth 13-19 years old

0.002195	11

Adults 20-49 years old

0.00184	9

Adults 50+ years old

0.001840	9

Females 13-49 years old

0.001775	9

The population subgroup with the highest estimated chronic dietary (food
+ drinking water) exposure and risk is indicated by bold text.

	VIII.   Conclusions

The results of the acute and chronic dietary assessments indicate that
dietary exposure to indoxacarb from food and drinking water is below
HED’s level of concern for the general U.S. population and all
population subgroups.

List of Attachments

RDFs for the Acute Analysis

Acute Food plus Water Residue Input file.

Chronic Food plus Water Residue Input file.

Acute Results file.

Chronic Results file.

Percent Crop Treated Memo from BEAD.

RDFs for the Acute Analysis

RDF 1

Apple, highest adjusted FTD (D244253, p.128)=0.74

ToTALZ=95

doc max %CT=5%

5,0.74

	RDF 2

Indoxacarb, Blueberry 

doc max CT=100%

totalz=0

0.20

0.27

0.28

0.30

0.32

0.35

0.38

0.38

0.42

0.51

0.52

0.53

0.55

0.56

0.58

0.58

0.59

0.63

0.73

0.80

0.81

0.81

0.84

0.84

1.03

1.04

RDF 3

Indoxacarb-Broccoli

doc Max %CT=50%

ToTALZ=20

doc adjusted for exaggeration rate (multiplied by 0.67) (MRID 44477401)

0.19

0.23

1.34

1.5

0.57

0.62

0.25

0.45

1.34

1.68

0.80

0.94

0.26

0.52

0.36

0.49

0.23

0.26

0.38

0.54	RDF 4

Indoxacarb-subgroup 5A, Broccoli FTD,  

doc Max %CT=55% of Cauliflower (highest)

ToTALZ=16

doc adjusted for exaggeration rate(multiplied by 0.67) (MRID 44477401)

0.19

0.23

1.34

1.5

0.57

0.62

0.25

0.45

1.34

1.68

0.80

0.94

0.26

0.52

0.36

0.49

0.23

0.26

0.38

0.54

RDF 5

Indoxacarb-Cabbage without Wrapper Leaves

doc Max %CT=25%

ToTALZ=72

0.02

0.04

0.01

0.03

0.08

0.11

0.05

0.05

0.03

0.07

0.06

0.1

0.01

0.02

0.11

0.21

0.02

0.03

0.03

0.04

0.02

0.02

0.03

0.08

	RDF 6

Indox-Cherries, 46651504.der

doc max CT= 2.5

Totalz=1248

.07

.07

.15

.45

.22

.19

.15

.16

.3

.51

.24

.12

.26

.31

.13

.62

.07

.07

.15

.45

.21

.19

.15

.15

.32

.51

.28

.15

.26

.32

.13

.64	RDF 7

Indoxacarb, Mustard Green FTD, PHI=3 days, D290126, 45718701.der

doc max CT=100%

totalz=0

3.5

3.4

1.2

1.2

9.6

10

9.5

9.4

RDF 8

Indoxacarb - Head Lettuce w/o wrapper leaves

doc 35% CT Max

TOTALZ=33

0.033

0.016

0.067

0.082

0.051

0.044

0.14

0.24

0.061

0.047

0.11

0.029

0.48

0.34

0.13

0.24

1.1

0.76	RDF 9

Indoxacarb - Leaf Lettuce

doc 11% CT Max

TOTALZ=146

8

8.7

6.8

7.9

6.6

5.6

3.5

4.6

6.6

7.7

5.9

7.2

8.3

8.1

3.4

3.7

2.7

2.9	RDF 10

Indox-Peach FTD, 46651505.der

ToTALZ=1170

doc max CT=2.5% 

.07

.26

.13

.03

.04

.1

.09

.3

.16

.19

.58

.07

.06

.29

.13

.04

.04

.3

.16

.2

.59

.07

.09

.09

.09

.09

.1

.1

.1

.1

RDF 11

Indox-Pear, highest FTD, D244253, p.128

doc max CT=2.5%

ToTALZ=39

0.08

	RDF 12

Indox-tomato, highest adjusted FTD, D244253

ToTALZ=75

25,0.27	RDF 13

Indox-fruiting veg. besides pepper and tomatoes

doc highest adjusted FTD for tomatoes is used, D244253

ToTALZ=0

doc max % CT=100%

0.27

RDF 14

Indox-Corn Sweet(k+CWHR), adjusted highest FTD, D244253

ToTALZ=39

doc max %CT=2.5

0.008	RDF 15

Indox-pepper(bell or non-bell), FTD, D244253

doc highest FTD used (adjusted for exaggeration)

ToTALZ=85

15,0.067

	RDF 18-20 blank

RDF 21

Indox-Mint, FTD, 46520902.der

doc max CT=100%

totalz=0

6.84

5.9

5.3

6.81

3.61

2.62

2.24

2.73

2.18

2.1

2.75

3.36

	RDF 22

Indox-Spinach FTD, 46487001.der

doc max CT=5%

totalz=304

7.9

13

2.5

4.5

3.7

3.3

5.7

5.7

4.7

4.3

4.3

4.2

7.2

6.7

2.2

4.4	RDF 23

Indox-Plum, FTD, 46651506.der

doc max CT=100%

TotalZ=0

.01

.01

.02

.02

.02

.03

.07

.04

.07

.19

.02

.02

.01

.02

.02

.02

.03

.07

.04

.07

.18

.01

RDF 24

Indox-trimmed celery, FTD x 2.5, see p.14 of D325479

doc max CT=100%

totalz=0

0.155

0.145

3.25

3

1.075

1.375

1.9

1.325

1.05

1.175

4.75

4	RDF 25

Indox-southern pea, FTD, 46520901.der

doc max CT=100%

totalz=0

4,.01

.0670

.0630

.0130

.0140

.0110

.0110

.0330

.0200

.0150

.0320	RDF 26

Indoxacarb, Grapes, FTD, D290126, 45900301.der, PHI=7 days

doc max CT=100%

totalz=0

0.196

0.163

1.72

1.32

0.133

0.198

0.105

0.0661

0.306

0.328

0.448

0.423

0.292

0.0888

0.482

0.353

1.35

1.31

0.447

0.329

RDF 27

indox-squash, FTD, 46651503.der

doc max CT=100%

totalz=0

0.12

.014

.11

.04

.01

.022

.035

.012

.026

.01

.01

.084

.013

.048

.032

.01

.034

.026

.013

.028

.01

.022

	RDF 28

Indox-Cucumber, FTD, 46651502.der

doc max CT=100%

totalz=0

.018

.015

.025

.025

.01

.023

.04

.031

.013

.019

.016

.02

.028

.014

.01

.022

.069

.031

.012

.018	RDF 29

Indox-Cantaloupe, FTD, 46651501.der

doc max CT=100%

totalz=0

0.027

0.247

0.13

.393

.088

.031

.05

.036

.05

.116

.018

.064

.197

.17

.23

.068

.022

.064

.035

.052

.124

.024	RDF 27

	RDF 28

RDF 30

Indox-Apricot, Nectarine, used Peach FTD, 46651505.der

ToTALZ=0

doc max CT=100%

.07

.26

.13

.03

.04

.1

.09

.3

.16

.19

.58

.07

.06

.29

.13

.04

.04

.3

.16

.2

.59

.07

.09

.09

.09

.09

.1

.1

.1

.1	RDF 31

Indox-cranberry, FTD, 46651507.der, PHI=28-30 days

doc max CT=100%

totalz=0

.086

.151

.099

.190

.13

.57

.146

.149

.11

.16

.11

.69	RDF 32

Indox-Spinach FTD, 46487001.der used for rest of group 4A (100% CT
assumption)

doc max CT=100%

totalz=0

7.9

13

2.5

4.5

3.7

3.3

5.7

5.7

4.7

4.3

4.3

4.2

7.2

6.7

2.2

4.4	RDF 31

	RDF 32

RDF 33

Indox-potato ; tolerance, D276516

doc max % CT=2.5

totalz=39

0.01	

RDF 16

Indoxacarb, garden beet root

doc max CT=100%

totalz=0

0.11

0.12

0.12

0.13

0.18

0.18

0.18

0.19

0.21

0.22

	RDF 17

Indoxacarb, garden beet tops 

doc max CT=100%

totalz=0

1.31

1.31

1.86

1.88

2.15

2.23

3.01

3.28

3.70

3.96

Attachment: Acute Food plus Water Residue Input File

Filename: C:\Documents and Settings\stadayon\My
Documents\Indoxacarb\067710a.R98

Chemical: Indoxacarb

RfD(Chronic): .02 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 0.12 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 11-13-2008/08:48:18/8          Program ver.
2.03

------------------------------------------------------------------------
--------

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1        Param #2  Param #3  Comment

  #   Code 

----- ---- ------------        --------  --------  -------

  1    6   Indoxacarb-041207-apple.rdf

  2    6   indoxacarb-Blueberry-FTD.rdf

  3    6   Indoxacarb-041207-broccoli.rdf

  4    6   Indoxacarb-041207-Grp5A-rest.rdf

  5    6   Indoxacarb-041107-cabbage-WithoutWrapper.rdf

  6    6   Indoxacarb-040907-cherries.rdf

  7    6   indoxacarb-040307-MustrdGrn-FTD.rdf

  8    6   Indoxacarb-041107-HeadLettuce-NoWrapper.rdf

  9    6   Indoxacarb-041707-LeafLettuce.rdf

  10   6   Indoxacarb-040907-peach.rdf

  11   6   Indoxacarb-041207-pear.rdf

  12   6   Indoxacarb-041507-tomato.rdf

  13   6   Indoxacarb-041507-FruitgVeg.rdf

  14   6   Indoxacarb-041707-sweet-corn.rdf

  15   6   Indoxacarb-041507-Pepper.rdf

  16   6   indoxacarb-garden beet root-FTD.rdf

  17   6   indoxacarb-garden beet top-FTD.rdf

  18   6   Indoxacarb-blank3.rdf

  19   6   Indoxacarb-blank4.rdf

  20   6   Indoxacarb-blank5.rdf

  21   6   Indoxacarb-041007-mint.rdf

  22   6   indoxacarb-040907-spinach.rdf

  23   6   Indoxacarb-040907-plum.rdf

  24   6   Indoxacarb-040907-3-dayPHI-UntrimdCelery.rdf

  25   6   Indoxacarb-040907-southern-pea.rdf

  26   6   indoxacarb-040307-grapeFTD.rdf

  27   6   Indoxacarb-041007.squash.rdf

  28   6   Indoxacarb-041007-cucumber.rdf

  29   6   Indoxacarb-041007-cantaloupe.rdf

  30   6   Indoxacarb-040907-Apricot-Nectarine.rdf

  31   6   Indoxacarb-041007-cranberry.rdf

  32   6   indoxacarb-042307-Grp-4A-rest.rdf

  33   6   Indoxacarb-042307-potato.rdf

  EPA    Crop Commodity Name                    Def Res     Adj.Factors 
RDL  Comment

  Code    Grp                                    (ppm)       #1     #2  
Pntr

-------- ---- -------------------------------  ----------  ------ ------
---  -------

01010500 1AB  Beet, garden, roots                0.300000   1.000  1.000
 16  

01010501 1AB  Beet, garden, roots-babyfood       0.300000   1.000  1.000
 16  

01030150 1CD  Arrowroot, flour                   0.010000   1.000  1.000
     

01030151 1CD  Arrowroot, flour-babyfood          0.010000   1.000  1.000
     

01030170 1CD  Artichoke, Jerusalem               0.010000   1.000  1.000
     

01030820 1CD  Cassava                            0.010000   1.000  1.000
     

01030821 1CD  Cassava-babyfood                   0.010000   1.000  1.000
     

01031390 1CD  Dasheen, corm                      0.010000   1.000  1.000
     

01031660 1CD  Ginger                             0.010000   1.000  1.000
     

01031661 1CD  Ginger-babyfood                    0.010000   1.000  1.000
     

01031670 1CD  Ginger, dried                      0.010000   1.000  1.000
     

01032960 1C   Potato, chips                      0.000100   0.850  1.000
     Blende

    Full comment: Blended, %CT unknown

01032970 1C   Potato, dry (granules/ flakes)     0.000100   0.850  1.000
     Blende

    Full comment: Blended

01032971 1C   Potato, dry (granules/ flakes)-b   0.000100   0.850  1.000
     Blende

    Full comment: Blended

01032980 1C   Potato, flour                      0.000100   1.000  1.000
     Blende

    Full comment: Blended

01032981 1C   Potato, flour-babyfood             0.000100   1.000  1.000
     Blende

    Full comment: Blended

01032990 1C   Potato, tuber, w/peel              0.010000   1.000  1.000
 33  

01032991 1C   Potato, tuber, w/peel-babyfood     0.010000   1.000  1.000
 33  

01033000 1C   Potato, tuber, w/o peel            0.010000   1.000  1.000
 33  

01033001 1C   Potato, tuber, w/o peel-babyfood   0.010000   1.000  1.000
 33  

01033660 1CD  Sweet potato                       0.010000   1.000  1.000
     

01033661 1CD  Sweet potato-babyfood              0.010000   1.000  1.000
     

01033710 1CD  Tanier, corm                       0.010000   1.000  1.000
     

01033870 1CD  Turmeric                           0.010000   1.000  1.000
     

01034060 1CD  Yam, true                          0.010000   1.000  1.000
     

01034070 1CD  Yam bean                           0.010000   1.000  1.000
     

02000510 2    Beet, garden, tops                 6.000000   1.000  1.000
 17  

04010050 4A   Amaranth, leafy                   14.000000   1.000  1.000
 32  

04010180 4A   Arugula                           14.000000   1.000  1.000
 32  

04011040 4A   Chrysanthemum, garland            14.000000   1.000  1.000
 32  

04011330 4A   Cress, garden                     14.000000   1.000  1.000
 32  

04011340 4A   Cress, upland                     14.000000   1.000  1.000
 32  

04011380 4A   Dandelion, leaves                 14.000000   1.000  1.000
 32  

04011500 4A   Endive                            14.000000   1.000  1.000
 32  

04012040 4A   Lettuce, head                     14.000000   1.000  1.000
  8  

04012050 4A   Lettuce, leaf                     14.000000   1.000  1.000
  9  

04012480 4A   Parsley, leaves                   14.000000   1.000  1.000
 32  

04013130 4A   Radicchio                         14.000000   1.000  1.000
 32  

04013550 4A   Spinach                           14.000000   1.000  1.000
 22  

04013551 4A   Spinach-babyfood                  14.000000   1.000  1.000
 22  

04020760 4B   Cardoon                           14.000000   1.000  1.000
 24  

04020850 4B   Celery                            14.000000   1.000  1.000
 24  

04020851 4B   Celery-babyfood                   14.000000   1.000  1.000
 24  

04020860 4B   Celery, juice                     14.000000   1.000  1.000
 24  

04020870 4B   Celtuce                           14.000000   1.000  1.000
 24  

04021520 4B   Fennel, Florence                  14.000000   1.000  1.000
 24  

04023220 4B   Rhubarb                           14.000000   1.000  1.000
 24  

04023670 4B   Swiss chard                       14.000000   1.000  1.000
 24  

05010610 5A   Broccoli                          12.000000   1.000  1.000
  3  

05010611 5A   Broccoli-babyfood                 12.000000   1.000  1.000
  3  

05010620 5A   Broccoli, Chinese                 12.000000   1.000  1.000
  3  

05010640 5A   Brussels sprouts                  12.000000   1.000  1.000
  4  

05010690 5A   Cabbage                           12.000000   1.000  1.000
  5  

05010710 5A   Cabbage, Chinese, napa            12.000000   1.000  1.000
  4  

05010720 5A   Cabbage, Chinese, mustard         12.000000   1.000  1.000
  4  

05010830 5A   Cauliflower                       12.000000   1.000  1.000
  4  

05011960 5A   Kohlrabi                          12.000000   1.000  1.000
  4  

05020630 5B   Broccoli raab                     12.000000   1.000  1.000
  7  

05020700 5B   Cabbage, Chinese, bok choy        12.000000   1.000  1.000
  7  

05021170 5B   Collards                          12.000000   1.000  1.000
  7  

05021940 5B   Kale                              12.000000   1.000  1.000
  7  

05022290 5B   Mustard greens                    12.000000   1.000  1.000
  7  

05023180 5B   Rape greens                       12.000000   1.000  1.000
  7  

05023890 5B   Turnip, greens                    12.000000   1.000  1.000
  7  

06003470 6    Soybean, seed                      0.000880   1.000  1.000
     Blende

    Full comment: Blended

06003480 6    Soybean, flour                     0.000880   1.000  1.000
     Blende

    Full comment: Blended

06003481 6    Soybean, flour-babyfood            0.000880   1.000  1.000
     Blende

    Full comment: Blended

06003490 6    Soybean, soy milk                  0.000880   1.000  1.000
     Blende

    Full comment: Blended

06003491 6    Soybean, soy milk-babyfood or in   0.000880   1.000  1.000
     Blende

    Full comment: Blended

06003500 6    Soybean, oil                       0.000880   0.640  1.000
     Blende

    Full comment: Blended

06003501 6    Soybean, oil-babyfood              0.000880   0.640  1.000
     Blende

    Full comment: Blended

06030340 6C   Bean, cowpea, seed                 0.100000   1.000  1.000
 25  

08001480 8    Eggplant                           0.270000   1.000  1.000
     

08002340 8    Okra                               0.270000   1.000  1.000
     

08002700 8    Pepper, bell                       0.500000   1.000  1.000
 15  

08002701 8    Pepper, bell-babyfood              0.500000   1.000  1.000
 15  

08002710 8    Pepper, bell, dried                0.010100   1.000  1.000
     Blende

    Full comment: Blended

08002711 8    Pepper, bell, dried-babyfood       0.010100   1.000  1.000
     Blende

    Full comment: Blended

08002720 8    Pepper, nonbell                    0.500000   1.000  1.000
 15  

08002721 8    Pepper, nonbell-babyfood           0.500000   1.000  1.000
 15  

08002730 8    Pepper, nonbell, dried             0.010100   1.000  1.000
     Blende

    Full comment: Blended

08003740 8    Tomatillo                          0.270000   1.000  1.000
     

08003750 8    Tomato                             0.500000   1.000  1.000
 12  

08003751 8    Tomato-babyfood                    0.500000   1.000  1.000
 12  

08003760 8    Tomato, paste                      0.067500   1.400  1.000
     Blende

    Full comment: Blended

08003761 8    Tomato, paste-babyfood             0.067500   1.400  1.000
     Blende

    Full comment: Blended

08003770 8    Tomato, puree                      0.067500   0.520  1.000
     Blende

    Full comment: Blended

08003771 8    Tomato, puree-babyfood             0.067500   0.520  1.000
     Blende

    Full comment: Blended

08003780 8    Tomato, dried                      0.067500  14.300  1.000
     Blende

    Full comment: Blended

08003781 8    Tomato, dried-babyfood             0.067500  14.300  1.000
     Blende

    Full comment: Blended

08003790 8    Tomato, juice                      0.500000   0.520  1.000
 12  

09010750 9A   Cantaloupe                         0.600000   1.000  1.000
 29  

09010800 9A   Casaba                             0.600000   1.000  1.000
 29  

09011870 9A   Honeydew melon                     0.600000   1.000  1.000
 29  

09013990 9A   Watermelon                         0.600000   1.000  1.000
 29  

09014000 9A   Watermelon, juice                  0.600000   1.000  1.000
 29  

09020210 9B   Balsam pear                        0.600000   1.000  1.000
 27  

09020880 9B   Chayote, fruit                     0.600000   1.000  1.000
 27  

09021020 9B   Chinese waxgourd                   0.600000   1.000  1.000
 27  

09021350 9B   Cucumber                           0.600000   1.000  1.000
 28  

09023080 9B   Pumpkin                            0.600000   1.000  1.000
 27  

09023090 9B   Pumpkin, seed                      0.600000   1.000  1.000
 27  

09023560 9B   Squash, summer                     0.600000   1.000  1.000
 27  

09023561 9B   Squash, summer-babyfood            0.600000   1.000  1.000
 27  

09023570 9B   Squash, winter                     0.600000   1.000  1.000
 27  

09023571 9B   Squash, winter-babyfood            0.600000   1.000  1.000
 27  

11000070 11   Apple, fruit with peel             1.000000   1.000  1.000
  1  

11000080 11   Apple, peeled fruit                1.000000   1.000  1.000
  1  

11000081 11   Apple, peeled fruit-babyfood       1.000000   1.000  1.000
  1  

11000090 11   Apple, dried                       0.037000   8.000  1.000
     

11000091 11   Apple, dried-babyfood              0.037000   8.000  1.000
     

11000100 11   Apple, juice                       1.000000   0.010  1.000
  1  

11000101 11   Apple, juice-babyfood              1.000000   0.010  1.000
  1  

11000110 11   Apple, sauce                       1.000000   1.000  1.000
  1  

11000111 11   Apple, sauce-babyfood              1.000000   1.000  1.000
  1  

11001290 11   Crabapple                          1.000000   1.000  1.000
  1  

11002100 11   Loquat                             1.000000   1.000  1.000
  1  

11002660 11   Pear                               0.110000   1.000  1.000
 11  

11002661 11   Pear-babyfood                      0.110000   1.000  1.000
 11  

11002670 11   Pear, dried                        0.002000   6.250  1.000
     Blende

    Full comment: Blended

11002680 11   Pear, juice                        0.110000   0.010  1.000
 11  

11002681 11   Pear, juice-babyfood               0.110000   0.010  1.000
 11  

11003100 11   Quince                             1.000000   1.000  1.000
  1  

12000120 12   Apricot                            0.900000   1.000  1.000
 30  

12000121 12   Apricot-babyfood                   0.900000   1.000  1.000
 30  

12000130 12   Apricot, dried                     0.155300   6.000  1.000
     

12000140 12   Apricot, juice                     0.900000   1.000  1.000
 30  

12000141 12   Apricot, juice-babyfood            0.900000   1.000  1.000
 30  

12000900 12   Cherry                             0.900000   1.000  1.000
  6  

12000901 12   Cherry-babyfood                    0.900000   1.000  1.000
  6  

12000910 12   Cherry, juice                      0.900000   1.500  1.000
  6  

12000911 12   Cherry, juice-babyfood             0.900000   1.500  1.000
  6  

12002300 12   Nectarine                          0.900000   1.000  1.000
 30  

12002600 12   Peach                              0.900000   1.000  1.000
 10  

12002601 12   Peach-babyfood                     0.900000   1.000  1.000
 10  

12002610 12   Peach, dried                       0.003900   4.000  1.000
     

12002611 12   Peach, dried-babyfood              0.003900   4.000  1.000
     

12002620 12   Peach, juice                       0.900000   1.000  1.000
 10  

12002621 12   Peach, juice-babyfood              0.900000   1.000  1.000
 10  

12002850 12   Plum                               0.900000   1.000  1.000
 23  

12002851 12   Plum-babyfood                      0.900000   1.000  1.000
 23  

12002860 12   Plum, prune, fresh                 0.900000   1.000  1.000
 23  

12002861 12   Plum, prune, fresh-babyfood        0.900000   1.000  1.000
 23  

12002870 12   Plum, prune, dried                 0.045000   4.000  1.000
     Blende

    Full comment: Blended

12002871 12   Plum, prune, dried-babyfood        0.045000   4.000  1.000
     Blende

    Full comment: Blended

12002880 12   Plum, prune, juice                 0.900000   1.400  1.000
 23  

12002881 12   Plum, prune, juice-babyfood        0.900000   1.400  1.000
 23  

13020570 13B  Blueberry                          1.500000   1.000  1.000
  2  

13020571 13B  Blueberry-babyfood                 1.500000   1.000  1.000
  2  

13021360 13B  Currant                            1.500000   1.000  1.000
  2  

13021370 13B  Currant, dried                     1.500000   1.000  1.000
  2  

13021490 13B  Elderberry                         1.500000   1.000  1.000
  2  

13021740 13B  Gooseberry                         1.500000   1.000  1.000
  2  

13021910 13B  Huckleberry                        1.500000   1.000  1.000
  2  

15001270 15   Corn, sweet                        0.020000   1.000  1.000
 14  

15001271 15   Corn, sweet-babyfood               0.020000   1.000  1.000
 14  

21000440 M    Beef, meat                         0.050000   1.000  1.000
     

21000441 M    Beef, meat-babyfood                0.050000   1.000  1.000
     

21000450 M    Beef, meat, dried                  0.050000   1.920  1.000
     

21000460 M    Beef, meat byproducts              0.030000   1.000  1.000
     

21000461 M    Beef, meat byproducts-babyfood     0.030000   1.000  1.000
     

21000470 M    Beef, fat                          1.500000   1.000  1.000
     

21000471 M    Beef,fat-babyfood                  1.500000   1.000  1.000
     

21000480 M    Beef, kidney                       0.030000   1.000  1.000
     

21000490 M    Beef, liver                        0.030000   1.000  1.000
     

21000491 M    Beef, liver-babyfood               0.030000   1.000  1.000
     

23001690 M    Goat, meat                         0.050000   1.000  1.000
     

23001700 M    Goat, meat byproducts              0.030000   1.000  1.000
     

23001710 M    Goat, fat                          1.500000   1.000  1.000
     

23001720 M    Goat, kidney                       0.030000   1.000  1.000
     

23001730 M    Goat, liver                        0.030000   1.000  1.000
     

24001890 M    Horse, meat                        0.050000   1.000  1.000
     

25002900 M    Pork, meat                         0.050000   1.000  1.000
     

25002901 M    Pork, meat-babyfood                0.050000   1.000  1.000
     

25002910 M    Pork, skin                         1.500000   1.000  1.000
     

25002920 M    Pork, meat byproducts              0.030000   1.000  1.000
     

25002921 M    Pork, meat byproducts-babyfood     0.030000   1.000  1.000
     

25002930 M    Pork, fat                          1.500000   1.000  1.000
     

25002931 M    Pork, fat-babyfood                 1.500000   1.000  1.000
     

25002940 M    Pork, kidney                       0.030000   1.000  1.000
     

25002950 M    Pork, liver                        0.030000   1.000  1.000
     

26003390 M    Sheep, meat                        0.050000   1.000  1.000
     

26003391 M    Sheep, meat-babyfood               0.050000   1.000  1.000
     

26003400 M    Sheep, meat byproducts             0.030000   1.000  1.000
     

26003410 M    Sheep, fat                         1.500000   1.000  1.000
     

26003411 M    Sheep, fat-babyfood                1.500000   1.000  1.000
     

26003420 M    Sheep, kidney                      0.030000   1.000  1.000
     

26003430 M    Sheep, liver                       0.030000   1.000  1.000
     

27002220 D    Milk, fat                          2.430000   1.000  1.000
     

27002221 D    Milk, fat - baby food/infant for   2.430000   1.000  1.000
     

27012230 D    Milk, nonfat solids                0.500000   1.000  1.000
     

27012231 D    Milk, nonfat solids-baby food/in   0.500000   1.000  1.000
     

40000930 P    Chicken, meat                      0.045000   1.000  1.000
     

40000931 P    Chicken, meat-babyfood             0.045000   1.000  1.000
     

40000940 P    Chicken, liver                     0.052000   1.000  1.000
     

40000950 P    Chicken, meat byproducts           0.052000   1.000  1.000
     

40000951 P    Chicken, meat byproducts-babyfoo   0.052000   1.000  1.000
     

40000960 P    Chicken, fat                       0.457000   1.000  1.000
     

40000961 P    Chicken, fat-babyfood              0.457000   1.000  1.000
     

40000970 P    Chicken, skin                      0.079000   1.000  1.000
     

40000971 P    Chicken, skin-babyfood             0.079000   1.000  1.000
     

50003820 P    Turkey, meat                       0.045000   1.000  1.000
     

50003821 P    Turkey, meat-babyfood              0.045000   1.000  1.000
     

50003830 P    Turkey, liver                      0.052000   1.000  1.000
     

50003831 P    Turkey, liver-babyfood             0.052000   1.000  1.000
     

50003840 P    Turkey, meat byproducts            0.052000   1.000  1.000
     

50003841 P    Turkey, meat byproducts-babyfood   0.052000   1.000  1.000
     

50003850 P    Turkey, fat                        0.460000   1.000  1.000
     

50003851 P    Turkey, fat-babyfood               0.460000   1.000  1.000
     

50003860 P    Turkey, skin                       0.079000   1.000  1.000
     

50003861 P    Turkey, skin-babyfood              0.079000   1.000  1.000
     

60003010 P    Poultry, other, meat               0.045000   1.000  1.000
     

60003020 P    Poultry, other, liver              0.052000   1.000  1.000
     

60003030 P    Poultry, other, meat byproducts    0.052000   1.000  1.000
     

60003040 P    Poultry, other, fat                0.457000   1.000  1.000
     

60003050 P    Poultry, other, skin               0.079000   1.000  1.000
     

70001450 P    Egg, whole                         0.119000   1.000  1.000
     

70001451 P    Egg, whole-babyfood                0.119000   1.000  1.000
     

70001460 P    Egg, white                         0.119000   1.000  1.000
     

70001461 P    Egg, white (solids)-babyfood       0.119000   1.000  1.000
     

70001470 P    Egg, yolk                          0.119000   1.000  1.000
     

70001471 P    Egg, yolk-babyfood                 0.119000   1.000  1.000
     

86010000 O    Water, direct, all sources         0.025000   1.000  1.000
     

86020000 O    Water, indirect, all sources       0.025000   1.000  1.000
     

95001280 O    Cottonseed, oil                    0.670000   0.040  1.000
     Blende

    Full comment: Blended

95001281 O    Cottonseed, oil-babyfood           0.670000   0.040  1.000
     Blende

    Full comment: Blended

95001300 O    Cranberry                          0.900000   1.000  1.000
 31  

95001301 O    Cranberry-babyfood                 0.900000   1.000  1.000
 31  

95001310 O    Cranberry, dried                   0.900000   1.000  1.000
 31  

95001320 O    Cranberry, juice                   0.900000   1.100  1.000
 31  

95001321 O    Cranberry, juice-babyfood          0.900000   1.100  1.000
 31  

95001750 O    Grape                              2.000000   1.000  1.000
 26  

95001760 O    Grape, juice                       2.000000   0.007  1.000
 26  

95001761 O    Grape, juice-babyfood              2.000000   0.007  1.000
 26  

95001770 O    Grape, leaves                      2.000000   1.000  1.000
 26  

95001780 O    Grape, raisin                      6.000000   2.700  1.000
 26  

95001790 O    Grape, wine and sherry             2.000000   1.000  1.000
 26  

95002630 O    Peanut                             0.000075   1.000  1.000
     Blende

    Full comment: Blended

95002640 O    Peanut, butter                     0.000075   1.890  1.000
     Blende

    Full comment: Blended

95002650 O    Peanut, oil                        0.000075   1.400  1.000
     Blende

    Full comment: Blended

95002750 O    Peppermint                         3.870000   1.000  1.000
 21  

95002760 O    Peppermint, oil                    3.870000   0.028  1.000
     Blende

    Full comment: Blended

95003520 O    Spearmint                          3.870000   1.000  1.000
 21  

95003530 O    Spearmint, oil                     3.870000   0.028  1.000
     Blende

    Full comment: Blended

	Attachment: Chronic Food plus Water Residue Input File

Filename: C:\Documents and Settings\stadayon\My
Documents\Indoxacarb\067710c.R98

Chemical: Indoxacarb

RfD(Chronic): .02 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .12 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 11-13-2008/08:47:30/8          Program ver.
2.03

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

01010500 1AB  Beet, garden, roots                0.160000   1.000  1.000
 

01010501 1AB  Beet, garden, roots-babyfood       0.160000   1.000  1.000
 

01030150 1CD  Arrowroot, flour                   0.010000   1.000  1.000
 

01030151 1CD  Arrowroot, flour-babyfood          0.010000   1.000  1.000
 

01030170 1CD  Artichoke, Jerusalem               0.010000   1.000  1.000
 

01030820 1CD  Cassava                            0.010000   1.000  1.000
 

01030821 1CD  Cassava-babyfood                   0.010000   1.000  1.000
 

01031390 1CD  Dasheen, corm                      0.010000   1.000  1.000
 

01031660 1CD  Ginger                             0.010000   1.000  1.000
 

01031661 1CD  Ginger-babyfood                    0.010000   1.000  1.000
 

01031670 1CD  Ginger, dried                      0.010000   1.000  1.000
 

01032960 1C   Potato, chips                      0.000040   1.000  1.000
 

01032970 1C   Potato, dry (granules/ flakes)     0.000040   0.850  1.000
 

01032971 1C   Potato, dry (granules/ flakes)-b   0.000040   0.850  1.000
 

01032980 1C   Potato, flour                      0.000040   1.000  1.000
 

01032981 1C   Potato, flour-babyfood             0.000040   1.000  1.000
 

01032990 1C   Potato, tuber, w/peel              0.000100   1.000  1.000
 

01032991 1C   Potato, tuber, w/peel-babyfood     0.000100   1.000  1.000
 

01033000 1C   Potato, tuber, w/o peel            0.000100   1.000  1.000
 

01033001 1C   Potato, tuber, w/o peel-babyfood   0.000100   1.000  1.000
 

01033660 1CD  Sweet potato                       0.010000   1.000  1.000
 

01033661 1CD  Sweet potato-babyfood              0.010000   1.000  1.000
 

01033710 1CD  Tanier, corm                       0.010000   1.000  1.000
 

01033870 1CD  Turmeric                           0.010000   1.000  1.000
 

01034060 1CD  Yam, true                          0.010000   1.000  1.000
 

01034070 1CD  Yam bean                           0.010000   1.000  1.000
 

02000510 2    Beet, garden, tops                 2.470000   1.000  1.000
 

04010050 4A   Amaranth, leafy                    5.270000   1.000  1.000
 

04010180 4A   Arugula                            5.270000   1.000  1.000
 

04011040 4A   Chrysanthemum, garland             5.270000   1.000  1.000
 

04011330 4A   Cress, garden                      5.270000   1.000  1.000
 

04011340 4A   Cress, upland                      5.270000   1.000  1.000
 

04011380 4A   Dandelion, leaves                  5.270000   1.000  1.000
 

04011500 4A   Endive                             5.270000   1.000  1.000
 

04012040 4A   Lettuce, head                      0.039700   1.000  1.000
 

04012050 4A   Lettuce, leaf                      0.541000   1.000  1.000
 

04012480 4A   Parsley, leaves                    5.270000   1.000  1.000
 

04013130 4A   Radicchio                          5.270000   1.000  1.000
 

04013550 4A   Spinach                            0.263400   1.000  1.000
 

04013551 4A   Spinach-babyfood                   0.263400   1.000  1.000
 

04020760 4B   Cardoon                            1.930000   1.000  1.000
 

04020850 4B   Celery                             1.930000   1.000  1.000
 

04020851 4B   Celery-babyfood                    1.930000   1.000  1.000
 

04020860 4B   Celery, juice                      1.930000   1.000  1.000
 

04020870 4B   Celtuce                            1.930000   1.000  1.000
 

04021520 4B   Fennel, Florence                   1.930000   1.000  1.000
 

04023220 4B   Rhubarb                            1.930000   1.000  1.000
 

04023670 4B   Swiss chard                        1.930000   1.000  1.000
 

05010610 5A   Broccoli                           0.259000   1.000  1.000
 

05010611 5A   Broccoli-babyfood                  0.259000   1.000  1.000
 

05010620 5A   Broccoli, Chinese                  0.226600   1.000  1.000
 

05010640 5A   Brussels sprouts                   0.226600   1.000  1.000
 

05010690 5A   Cabbage                            0.008700   1.000  1.000
 

05010710 5A   Cabbage, Chinese, napa             0.226600   1.000  1.000
 

05010720 5A   Cabbage, Chinese, mustard          0.226600   1.000  1.000
 

05010830 5A   Cauliflower                        0.226600   1.000  1.000
 

05011960 5A   Kohlrabi                           0.226600   1.000  1.000
 

05020630 5B   Broccoli raab                      5.980000   1.000  1.000
 

05020700 5B   Cabbage, Chinese, bok choy         5.980000   1.000  1.000
 

05021170 5B   Collards                           5.980000   1.000  1.000
 

05021940 5B   Kale                               5.980000   1.000  1.000
 

05022290 5B   Mustard greens                     5.980000   1.000  1.000
 

05023180 5B   Rape greens                        5.980000   1.000  1.000
 

05023890 5B   Turnip, greens                     5.980000   1.000  1.000
 

06003470 6    Soybean, seed                      0.000880   1.000  1.000
 

06003480 6    Soybean, flour                     0.000880   1.000  1.000
 

06003481 6    Soybean, flour-babyfood            0.000880   1.000  1.000
 

06003490 6    Soybean, soy milk                  0.000880   1.000  1.000
 

06003491 6    Soybean, soy milk-babyfood or in   0.000880   1.000  1.000
 

06003500 6    Soybean, oil                       0.000880   0.640  1.000
 

06003501 6    Soybean, oil-babyfood              0.000880   0.640  1.000
 

06030340 6C   Bean, cowpea, seed                 0.022800   1.000  1.000
 

08001480 8    Eggplant                           0.270000   1.000  1.000
 

08002340 8    Okra                               0.270000   1.000  1.000
 

08002700 8    Pepper, bell                       0.006700   1.000  1.000
 

08002701 8    Pepper, bell-babyfood              0.006700   1.000  1.000
 

08002710 8    Pepper, bell, dried                0.006700   1.000  1.000
 

08002711 8    Pepper, bell, dried-babyfood       0.006700   1.000  1.000
 

08002720 8    Pepper, nonbell                    0.006700   1.000  1.000
 

08002721 8    Pepper, nonbell-babyfood           0.006700   1.000  1.000
 

08002730 8    Pepper, nonbell, dried             0.006700   1.000  1.000
 

08003740 8    Tomatillo                          0.270000   1.000  1.000
 

08003750 8    Tomato                             0.040500   1.000  1.000
 

08003751 8    Tomato-babyfood                    0.040500   1.000  1.000
 

08003760 8    Tomato, paste                      0.040500   1.400  1.000
 

08003761 8    Tomato, paste-babyfood             0.040500   1.400  1.000
 

08003770 8    Tomato, puree                      0.040500   0.520  1.000
 

08003771 8    Tomato, puree-babyfood             0.040500   0.520  1.000
 

08003780 8    Tomato, dried                      0.040500  14.300  1.000
 

08003781 8    Tomato, dried-babyfood             0.040500  14.300  1.000
 

08003790 8    Tomato, juice                      0.040500   0.520  1.000
 

09010750 9A   Cantaloupe                         0.101600   1.000  1.000
 

09010800 9A   Casaba                             0.101600   1.000  1.000
 

09011870 9A   Honeydew melon                     0.101600   1.000  1.000
 

09013990 9A   Watermelon                         0.101600   1.000  1.000
 

09014000 9A   Watermelon, juice                  0.101600   1.000  1.000
 

09020210 9B   Balsam pear                        0.033000   1.000  1.000
 

09020880 9B   Chayote, fruit                     0.033100   1.000  1.000
 

09021020 9B   Chinese waxgourd                   0.033100   1.000  1.000
 

09021350 9B   Cucumber                           0.023000   1.000  1.000
 

09023080 9B   Pumpkin                            0.033100   1.000  1.000
 

09023090 9B   Pumpkin, seed                      0.033100   1.000  1.000
 

09023560 9B   Squash, summer                     0.033100   1.000  1.000
 

09023561 9B   Squash, summer-babyfood            0.033100   1.000  1.000
 

09023570 9B   Squash, winter                     0.033100   1.000  1.000
 

09023571 9B   Squash, winter-babyfood            0.033100   1.000  1.000
 

11000070 11   Apple, fruit with peel             0.007400   1.000  1.000
 

11000080 11   Apple, peeled fruit                0.007400   1.000  1.000
 

11000081 11   Apple, peeled fruit-babyfood       0.007400   1.000  1.000
 

11000090 11   Apple, dried                       0.007400   8.000  1.000
 

11000091 11   Apple, dried-babyfood              0.007400   8.000  1.000
 

11000100 11   Apple, juice                       0.007400   0.010  1.000
 

11000101 11   Apple, juice-babyfood              0.007400   0.010  1.000
 

11000110 11   Apple, sauce                       0.007400   1.000  1.000
 

11000111 11   Apple, sauce-babyfood              0.007400   1.000  1.000
 

11001290 11   Crabapple                          0.740000   1.000  1.000
 

11002100 11   Loquat                             0.740000   1.000  1.000
 

11002660 11   Pear                               0.000800   1.000  1.000
 

11002661 11   Pear-babyfood                      0.000800   1.000  1.000
 

11002670 11   Pear, dried                        0.000800   6.250  1.000
 

11002680 11   Pear, juice                        0.000800   0.010  1.000
 

11002681 11   Pear, juice-babyfood               0.000800   0.010  1.000
 

11003100 11   Quince                             0.740000   1.000  1.000
 

12000120 12   Apricot                            0.155000   1.000  1.000
 

12000121 12   Apricot-babyfood                   0.155000   1.000  1.000
 

12000130 12   Apricot, dried                     0.155000   6.000  1.000
 

12000140 12   Apricot, juice                     0.155000   1.000  1.000
 

12000141 12   Apricot, juice-babyfood            0.155000   1.000  1.000
 

12000900 12   Cherry                             0.002500   1.000  1.000
 

12000901 12   Cherry-babyfood                    0.002500   1.000  1.000
 

12000910 12   Cherry, juice                      0.002500   1.500  1.000
 

12000911 12   Cherry, juice-babyfood             0.002500   1.500  1.000
 

12002300 12   Nectarine                          0.155300   1.000  1.000
 

12002600 12   Peach                              0.001600   1.000  1.000
 

12002601 12   Peach-babyfood                     0.001600   1.000  1.000
 

12002610 12   Peach, dried                       0.001600   4.000  1.000
 

12002611 12   Peach, dried-babyfood              0.001600   4.000  1.000
 

12002620 12   Peach, juice                       0.001600   1.000  1.000
 

12002621 12   Peach, juice-babyfood              0.001600   1.000  1.000
 

12002850 12   Plum                               0.045000   1.000  1.000
 

12002851 12   Plum-babyfood                      0.045000   1.000  1.000
 

12002860 12   Plum, prune, fresh                 0.045000   1.000  1.000
 

12002861 12   Plum, prune, fresh-babyfood        0.045000   1.000  1.000
 

12002870 12   Plum, prune, dried                 0.045000   4.000  1.000
 

12002871 12   Plum, prune, dried-babyfood        0.045000   4.000  1.000
 

12002880 12   Plum, prune, juice                 0.045000   1.000  1.000
 

12002881 12   Plum, prune, juice-babyfood        0.045000   1.000  1.000
 

13020570 13B  Blueberry                          0.570000   1.000  1.000
 

13020571 13B  Blueberry-babyfood                 0.570000   1.000  1.000
 

13021360 13B  Currant                            0.570000   1.000  1.000
 

13021370 13B  Currant, dried                     0.570000   1.000  1.000
 

13021490 13B  Elderberry                         0.570000   1.000  1.000
 

13021740 13B  Gooseberry                         0.570000   1.000  1.000
 

13021910 13B  Huckleberry                        0.570000   1.000  1.000
 

15001270 15   Corn, sweet                        0.000080   1.000  1.000
 

15001271 15   Corn, sweet-babyfood               0.000080   1.000  1.000
 

21000440 M    Beef, meat                         0.050000   1.000  1.000
 

21000441 M    Beef, meat-babyfood                0.050000   1.000  1.000
 

21000450 M    Beef, meat, dried                  0.050000   1.920  1.000
 

21000460 M    Beef, meat byproducts              0.030000   1.000  1.000
 

21000461 M    Beef, meat byproducts-babyfood     0.030000   1.000  1.000
 

21000470 M    Beef, fat                          1.500000   1.000  1.000
 

21000471 M    Beef,fat-babyfood                  1.500000   1.000  1.000
 

21000480 M    Beef, kidney                       0.030000   1.000  1.000
 

21000490 M    Beef, liver                        0.030000   1.000  1.000
 

21000491 M    Beef, liver-babyfood               0.030000   1.000  1.000
 

23001690 M    Goat, meat                         0.050000   1.000  1.000
 

23001700 M    Goat, meat byproducts              0.030000   1.000  1.000
 

23001710 M    Goat, fat                          1.500000   1.000  1.000
 

23001720 M    Goat, kidney                       0.030000   1.000  1.000
 

23001730 M    Goat, liver                        0.030000   1.000  1.000
 

24001890 M    Horse, meat                        0.050000   1.000  1.000
 

25002900 M    Pork, meat                         0.050000   1.000  1.000
 

25002901 M    Pork, meat-babyfood                0.050000   1.000  1.000
 

25002910 M    Pork, skin                         1.500000   1.000  1.000
 

25002920 M    Pork, meat byproducts              0.030000   1.000  1.000
 

25002921 M    Pork, meat byproducts-babyfood     0.030000   1.000  1.000
 

25002930 M    Pork, fat                          1.500000   1.000  1.000
 

25002931 M    Pork, fat-babyfood                 1.500000   1.000  1.000
 

25002940 M    Pork, kidney                       0.030000   1.000  1.000
 

25002950 M    Pork, liver                        0.030000   1.000  1.000
 

26003390 M    Sheep, meat                        0.050000   1.000  1.000
 

26003391 M    Sheep, meat-babyfood               0.050000   1.000  1.000
 

26003400 M    Sheep, meat byproducts             0.030000   1.000  1.000
 

26003410 M    Sheep, fat                         1.500000   1.000  1.000
 

26003411 M    Sheep, fat-babyfood                1.500000   1.000  1.000
 

26003420 M    Sheep, kidney                      0.030000   1.000  1.000
 

26003430 M    Sheep, liver                       0.030000   1.000  1.000
 

27002220 D    Milk, fat                          2.430000   1.000  1.000
 

27002221 D    Milk, fat - baby food/infant for   2.430000   1.000  1.000
 

27012230 D    Milk, nonfat solids                0.500000   1.000  1.000
 

27012231 D    Milk, nonfat solids-baby food/in   0.500000   1.000  1.000
 

40000930 P    Chicken, meat                      0.045000   1.000  1.000
 

40000931 P    Chicken, meat-babyfood             0.045000   1.000  1.000
 

40000940 P    Chicken, liver                     0.052000   1.000  1.000
 

40000950 P    Chicken, meat byproducts           0.052000   1.000  1.000
 

40000951 P    Chicken, meat byproducts-babyfoo   0.052000   1.000  1.000
 

40000960 P    Chicken, fat                       0.457000   1.000  1.000
 

40000961 P    Chicken, fat-babyfood              0.457000   1.000  1.000
 

40000970 P    Chicken, skin                      0.079000   1.000  1.000
 

40000971 P    Chicken, skin-babyfood             0.079000   1.000  1.000
 

50003820 P    Turkey, meat                       0.045000   1.000  1.000
 

50003821 P    Turkey, meat-babyfood              0.045000   1.000  1.000
 

50003830 P    Turkey, liver                      0.052000   1.000  1.000
 

50003831 P    Turkey, liver-babyfood             0.052000   1.000  1.000
 

50003840 P    Turkey, meat byproducts            0.052000   1.000  1.000
 

50003841 P    Turkey, meat byproducts-babyfood   0.052000   1.000  1.000
 

50003850 P    Turkey, fat                        0.457000   1.000  1.000
 

50003851 P    Turkey, fat-babyfood               0.457000   1.000  1.000
 

50003860 P    Turkey, skin                       0.079000   1.000  1.000
 

50003861 P    Turkey, skin-babyfood              0.079000   1.000  1.000
 

60003010 P    Poultry, other, meat               0.045000   1.000  1.000
 

60003020 P    Poultry, other, liver              0.052000   1.000  1.000
 

60003030 P    Poultry, other, meat byproducts    0.052000   1.000  1.000
 

60003040 P    Poultry, other, fat                0.457000   1.000  1.000
 

60003050 P    Poultry, other, skin               0.079000   1.000  1.000
 

70001450 P    Egg, whole                         0.119000   1.000  1.000
 

70001451 P    Egg, whole-babyfood                0.119000   1.000  1.000
 

70001460 P    Egg, white                         0.119000   1.000  1.000
 

70001461 P    Egg, white (solids)-babyfood       0.119000   1.000  1.000
 

70001470 P    Egg, yolk                          0.119000   1.000  1.000
 

70001471 P    Egg, yolk-babyfood                 0.119000   1.000  1.000
 

86010000 O    Water, direct, all sources         0.005370   1.000  1.000
 ave. 1

          Full comment: ave. 1 in 10 yr, cotton scenario

86020000 O    Water, indirect, all sources       0.005370   1.000  1.000
 ave. 1

          Full comment: ave. 1 in 10 yr, cotton scenario

95001280 O    Cottonseed, oil                    0.670000   0.040  1.000
 

95001281 O    Cottonseed, oil-babyfood           0.670000   0.040  1.000
 

95001300 O    Cranberry                          0.216000   1.000  1.000
 

95001301 O    Cranberry-babyfood                 0.216000   1.000  1.000
 

95001310 O    Cranberry, dried                   0.216000   1.000  1.000
 

95001320 O    Cranberry, juice                   0.216000   1.100  1.000
 

95001321 O    Cranberry, juice-babyfood          0.216000   1.100  1.000
 

95001750 O    Grape                              0.503000   1.000  1.000
 

95001760 O    Grape, juice                       0.503000   0.007  1.000
 

95001761 O    Grape, juice-babyfood              0.503000   0.007  1.000
 

95001770 O    Grape, leaves                      0.503000   1.000  1.000
 

95001780 O    Grape, raisin                      0.503000   2.700  1.000
 

95001790 O    Grape, wine and sherry             0.503000   1.000  1.000
 

95002630 O    Peanut                             0.000030   1.000  1.000
 

95002640 O    Peanut, butter                     0.000030   1.890  1.000
 

95002650 O    Peanut, oil                        0.000030   1.400  1.000
 

95002750 O    Peppermint                         3.870000   1.000  1.000
 

95002760 O    Peppermint, oil                    3.870000   0.028  1.000
 

95003520 O    Spearmint                          3.870000   1.000  1.000
 

95003530 O    Spearmint, oil                     3.870000   0.028  1.000
 

Attachment:  Acute Food plus Water Results File

U.S. Environmental Protection Agency                                 
Ver. 2.02

DEEM-FCID ACUTE Analysis for INDOXACARB                         
(1994-98 data)

Residue file: 067710a.R98                             Adjustment factor
#2 used.

Analysis Date: 01-08-2009/10:39:37    Residue file dated:
01-08-2009/10:18:27/8

Daily totals for food and food form consumption used.

MC iterations = 1000      MC list in residue file     MC seed = 10

Run Comment: ""

========================================================================
=======

Summary calculations (per capita):

                    95th Percentile      99th Percentile      99.9th
Percentile

                   Exposure   % aRfD    Exposure   % aRfD    Exposure  
% aRfD 

                  ---------- --------  ---------- --------  ----------
--------

U.S. Population:

                    0.007942     6.62    0.015191    12.66    0.034659  
 28.88 

All infants:

                    0.010902     9.08    0.021792    18.16    0.039785  
 33.15 

Children 1-2 yrs:

                    0.018126    15.11    0.027386    22.82    0.069736  
 58.11 

Children 3-5 yrs:

                    0.013473    11.23    0.022014    18.35    0.076144  
 63.45 

Children 6-12 yrs:

                    0.008765     7.30    0.013440    11.20    0.029425  
 24.52 

Youth 13-19 yrs:

                    0.005655     4.71    0.011610     9.67    0.039554  
 32.96 

Adults 20-49 yrs:

                    0.005038     4.20    0.009706     8.09    0.027255  
 22.71 

Adults 50+ yrs:

                    0.004996     4.16    0.013044    10.87    0.031850  
 26.54 

Attachment:  Chronic Food plus Water Results File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for INDOXACARB                       (1994-98
data)

Residue file name: C:\Documents and Settings\stadayon\My
Documents\Indoxacarb\067710c.R98

                                                     Adjustment factor
#2 used.

Analysis Date 01-08-2009/08:22:06     Residue file dated:
01-08-2009/06:50:28/8

Reference dose (RfD, Chronic) = .02 mg/kg bw/day

COMMENT 1: Revised dietary assessment incorporating tox PODs for
indoxacarb mixture (KN127 and KN128 isomers)

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.002465               
12.3%

U.S. Population (spring season)             0.002467               
12.3%

U.S. Population (summer season)             0.002501               
12.5%

U.S. Population (autumn season)             0.002508               
12.5%

U.S. Population (winter season)             0.002377               
11.9%

Northeast region                            0.002567               
12.8%

Midwest region                              0.002446               
12.2%

Southern region                             0.002345               
11.7%

Western region                              0.002584               
12.9%

Hispanics                                   0.002617               
13.1%

Non-hispanic whites                         0.002309               
11.5%

Non-hispanic blacks                         0.003020               
15.1%

Non-hisp/non-white/non-black                0.003075               
15.4%

All infants (< 1 year)                      0.002468               
12.3%

Nursing infants                             0.000802                
4.0%

Non-nursing infants                         0.003101               
15.5%

Children 1-6  yrs                           0.006476               
32.4%

Children 7-12 yrs                           0.003453               
17.3%

Females 13-19 (not preg or nursing)         0.001890                
9.4%

Females 20+ (not preg or nursing)           0.001768                
8.8%

Females 13-50 yrs                           0.001926                
9.6%

Females 13+ (preg/not nursing)              0.001967                
9.8%

Females 13+ (nursing)                       0.001967                
9.8%

Males 13-19 yrs                             0.002481               
12.4%

Males 20+ yrs                               0.001920                
9.6%

Seniors 55+                                 0.001862                
9.3%

Children 1-2 yrs                            0.007884               
39.4%

Children 3-5 yrs                            0.006041               
30.2%

Children 6-12 yrs                           0.003684               
18.4%

Youth 13-19 yrs                             0.002195               
11.0%

Adults 20-49 yrs                            0.001845                
9.2%

Adults 50+ yrs                              0.001840                
9.2%

Females 13-49 yrs                           0.001775                
8.9%

------------------------------------------------------------------------
-------

 

 BEAD Projected %CT Data

April 2, 2007

Screening Level Estimates of Agricultural Uses of Indoxacarb  067710

Sorted Alphabetically

	  		  	 	

		Crop				Lbs. A.I.			Percent Crop Treated

	  	 								Avg	      Max

	2 	Alfalfa	10,000	<1            <2.5

	3 	Apples	1,000	<1              5

	4 	Broccoli**	4,000	40             50

	5 	Brussels Sprouts*	<500	N/C          N/C

	6 	Cabbage	2,000	15             25

	7 	Cauliflower**	1,000	35             55

	8 	Cherries	<500	<1            <2.5

	9 	Cotton	30,000	<1              5

	10	Lettuce***	6,000	20             35

	11	Peaches	<500	<1            <2.5

	12	Peanuts	<500	<1            <2.5

	13	Pears	<500	<1            <2.5

	14	Peppers	1,000	10             15

	15	Potatoes	1,000	<1            <2.5

	17	Spinach	<500	  5              5

	18	Sweet Corn	<500	<1            <2.5

	19	Tomatoes	4,000	15             25

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All numbers rounded.		

'<500' indicates less than 500 pounds of active ingredient.		

'<2.5' indicates less than 2.5 percent of crop is treated.		

'<1' indicates less than 1 percent of crop is treated.	

* CA data only, but 95% or more of U.S. acres are in California		

** Electronic communication, A. Halvorson to S. Levy, 10-MAY-2007
(Either cauliflower or broccoli %CT may be used for the following 4
minor crops:  Chinese broccoli, Chinese napa cabbage, Chinese mustard
cabbage, and kohlrabi.)

*** Electronic communication, A. Halvorson to M. Sahafeyan, 12-APR-2007
(head lettuce:  18% average, 25% maximum; other lettuce:  9% average,
11% maximum)

N/C = Not Calculated

 ai = active ingredient is defined as the S isomer of indoxacarb
(KN128).  The R isomer (KN127) is an inactive isomer.  

Indoxacarb	Dietary Exposure Assessment	DP Bar code:D356924

PC Code: 067710		Page: Page   PAGE  1  of   NUMPAGES  35