Document ID: EPA-HQ-OPP-2005-0145-0011
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2006-12-20T05:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF              

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES 

MEMORANDUM

DATE:  	October 20, 2006

SUBJECT:	Boscalid: Chronic Dietary Exposure Assessment for the Section 3
Registration Action on Leafy Greens Subgroup 4A, except Head and Leaf
Lettuce, and Leaf Petioles Subgroup 4B

PC Code:	128008

DP Number:	332672

Petition Number:  3E6791

REVIEWER:	Shaja R. Brothers, Risk Review Manager 

Minor Use Team/Risk Integration Minor Use Emergency Response Branch

Registration Division (7505P)

THROUGH:	William Cutchin, Chemist

ARIA Team/Risk Technical Review Branch

Registration Division (7505P)

and

Thomas Bloem, Chemist

David Soderberg, Chemist

DESAC/Health Effects Division (7509P)

TO:		Shaja R. Brothers, Risk Review Manager 

Risk Integration Minor Use Emergency Response Branch

		Registration Division (7505P)

Executive Summary

An analysis was performed to support a Section 3 request for tolerances
for residues of boscalid on Leafy Greens Subgroup 4A, except head and
leaf lettuce at 60 ppm, and leaf petioles subgroup 4B at 45 ppm. 
Although tolerances were formerly established for celery and spinach,
the Interregional Research Project Number 4 (IR-4) subsequently
requested tolerances for the subgroups identified above.  As a result,
this chronic dietary exposure assessment supersedes the previous
boscalid assessment (D. Dotson, DP Number 321557, 11/3/05), and replaces
the existing tolerances for celery at 45 ppm and spinach at 60 ppm.  A
chronic dietary risk assessment was conducted using the Dietary Exposure
Evaluation Model (DEEM-FCID, Version 2.03), which uses food consumption
data from the USDA’s Continuing Surveys of Food Intakes by Individuals
(CSFII) from 1994-1996 and 1998.     

Chronic Dietary Exposure Results and Characterization

The chronic dietary exposure analysis was based on tolerance level
residues and 100% crop treated assumptions.  DEEM (Version 7.81) default
processing factors were used for some commodities. The chronic surface
water concentration for use in the chronic dietary exposure analysis is
0.02577 ppm.  The general U.S. population and all population subgroups
had risk estimates that were below the Agency’s level of concern. 
This analysis is very conservative as further refinements were not
required for this assessment.  The chronic population adjusted dose
(cPAD) for the most highly exposed population subgroup is for children
1-2 years at 38%, and the general US population at 11%.  

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose 

(i.e. HED’s concluded dose response at which no unreasonable adverse
health effects will occur).  This dose is referred to as the population
adjusted dose (PAD).  The PAD is equivalent to the Reference Dose (RfD)
divided by the special FQPA Safety Factor.

For acute and non-cancer chronic exposures, the Health Effects Division
(HED) is concerned when estimated dietary risk exceeds 100% of the PAD. 
HED is generally concerned when estimated cancer risk exceeds one in one
million (i.e., the risk exceeds 1 x 10-6).  References which discuss the
acute and chronic risk assessments in more detail are available on the
EPA/pesticides web site:  “Available Information on Assessing Exposure
from Pesticides, A User’s Guide,” 6/21/2000, web link: 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see
SOP 99.6 (8/20/99).

The most recent dietary exposure assessment for boscalid was conducted
by D. Dotson (DP Number 321557, 11/3/2005).

II.	Residue Information

Boscalid tolerances were initially established in 40CFR §180.589 on
July 30, 2003.  These tolerances included those for primary crops,
rotational crops, and livestock commodities.  A 

time-limited tolerance for tangerines has also been established in
conjunction with a Section 18 emergency exemption request, and is
currently set to expire December 2008.  Subsequently IR-4 is requesting
tolerances for the Leafy Greens Subgroup 4A, except head and leaf
lettuce at 60 ppm, and leaf petioles subgroup 4B at 45 ppm.  These
proposed tolerances will replace the existing tolerances for celery and
spinach.

Residues in drinking water are being included directly in the analysis. 
The estimated drinking water concentration was provided by the
Environmental Fate and Effects Division (EFED).  It was derived from a
Tier 1 FIRST assessment for use on turf.  The chronic surface water
concentration for use in the chronic dietary exposure analysis is
0.02577 ppm.

Boscalid parent is the residue of concern for both the tolerance
expression and risk assessment in target and rotational crops.  In
livestock, the residues of concern for both the tolerance expression and
risk assessment are the combined residues of boscalid and the free and
conjugated hydroxy metabolites (M510F01 and M510F02).  Tolerance level
residues were used for all commodities.  DEEM (Version 7.81) default
processing factors (adjustment factor #1) were used for some
commodities.  Processing factors were used to modify the tolerances in
four separate entities.  For some commodities, processing studies
demonstrated residues of boscalid do not concentrate. For these
commodities the raw agricultural commodity (RAC) tolerance was used and
adjustment factor #1 (the processing factor) was set to 1.000.  In some
other instances, for some commodities the processing studies
demonstrated that there was a slight concentration of residues upon
processing.  In these cases, the tolerance for the RAC was adequate to
cover residues in processed commodities.  Adjustment factor #1 was set
to 1.000.  In other cases, for some commodities residues concentrated
enough in the processing studies that separate tolerances were
established for the processed commodities.  These tolerances were used
in the assessment and adjustment factor #1 was set to 1.000.  For the
other processed commodities, for which data are not available, DEEM
(Version 7.81) default processing factors were used.  

A review of the processing studies for the registered commodities
(except apples and soybeans) can be found in the residue chemistry
summary document that included the first established tolerances for
boscalid (Memo, DP Number 278385, M. Nelson, 8/15/03).  A review of the
processing studies for apples and soybeans can be found in the residue
chemistry summary document that included those commodities (Memo, DP
Number 290185, D. Dotson, 2/10/04).

III.	DEEM-FCID( Program and Consumption Information

A boscalid chronic dietary exposure assessment was conducted using the
Dietary Exposure Evaluation Model software with the Food Commodity
Intake Database (DEEM-FCID(, Version 2.03), which incorporates
consumption data from USDA’s Continuing Surveys of Food Intakes by
Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98 data are based
on the reported consumption of more than 20,000 individuals over two
non-consecutive survey days.  Foods “as consumed” (e.g., apple pie)
are linked to EPA-defined food commodities (e.g. apples, peeled fruit -
cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S,
baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA.  For chronic exposure assessment,
consumption data are averaged for the entire U.S. population and within
population subgroups, but for acute exposure assessment are retained as
individual consumption events.  Based on analysis of the 1994-96, 98
CSFII consumption data, which took into account dietary patterns and
survey respondents, ARIA reports risks for the corresponding population
subgroups: the general U.S. population, all infants (<1 year old),
children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49,
females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form.  The resulting residue
consumption estimate for each food/food form is summed with the residue
consumption estimates for all other food/food forms on the commodity
residue list to arrive at the total average estimated exposure. 
Exposure is expressed in mg/kg body weight/day and as a percent of the
cPAD.  This procedure is performed for each population subgroup.

IV.	Toxicological Information

HED’s Hazard Identification Assessment Review Committee (HIARC) met on
September 5, 2002 and January 23, 2003 to evaluate the toxicology
database for boscalid (Report dated 3/7/03, TXR No. 0051613).  The
findings of the HIARC relative to dietary exposure are summarized in
Table 1.  No appropriate endpoint was identified for assessing acute
exposures, and boscalid was given a carcinogen classification of
“Suggestive evidence of carcinogenicity, but not sufficient to assess
human carcinogenic potential.”  As such, only a chronic dietary
analysis is required.

Table 1.  Summary of Toxicological Doses and Endpoints for Use in Human
Health Dietary

Risk Assessment for Boscalid (HIARC, 3/7/03, TXR No. 0051613)

Exposure

Scenario	

Dose Used in Risk Assessment, UF 	

Special FQPA SF* and Level of Concern for Risk Assessment	

Study and Toxicological Effects

Acute Dietary	

No appropriate endpoint identified	

NA	

NA

	

Chronic Dietary

(All populations)	

NOAEL = 21.8 mg/kg/day

UF = 100

Chronic RfD = 0.218 mg/kg/day	

FQPA SF = 1X

cPAD = chronic RfD 

               FQPA SF

= 0.218 mg/kg/day	

Chronic rat, carcinogenicity rat and 1-year dog studies

LOAEL = 57-58 mg/kg/day based    on liver and thyroid effects

Cancer 	

Classification: “Suggestive evidence of carcinogenicity, but not
sufficient to assess human carcinogenic potential.”

Results

The analyses summarized in Table 2 are based on tolerance-level
residues (in some cases modified by DEEM (Version 7.81) default
processing factors), and assume 100% crop treated.  These assumptions
are highly conservative.  Thus, risk estimates are below the Agency’s
level of concern.  The most highly exposed population subgroup is
children 1-2 years, which utilizes 38% of the cPAD.  The general U.S.
population utilizes 11% of the cPAD.

Table 2.  Summary of Dietary Exposure and Risk for Boscalid

Population Subgroup	

Acute Analysis	

DEEM: Chronic Analysis	

Cancer Analysis

Dietary Exposure (mg/kg/day)	

% cPAD

	

General U.S. Population	Not Applicable:  No Acute Dietary Endpoint	

0.023311	

11	

Not Applicable: No cancer risk assessment is required

All Infants (< 1 year old)

0.052281	

24

	

Children 1-2 years old

0.082483	

38

	

Children 3-5 years old

0.056792	

26

	

Children 6-12 years old

0.028500	

13

	

Youth 13-19 years old

0.016295	

8

	

Adults 20-49 years old

0.017377	

8

	

Adults 50+ years old

0.019261	

9

	

Females 13-49 years old

0.017586	

8

	

VI.	Characterization of Inputs/Outputs

The assumptions made in this assessment are conservative.  Therefore,
ARIA is confident that this analysis does not underestimate risk to the
general U.S. population or other population subgroups.  

VII.	Conclusions

Dietary risk estimates to boscalid do not exceed the Agency’s level of
concern for the general U.S. population and other population subgroups.

Attachment 1: Residue Input File for Chronic Analysis

Filename: E:\ARIA\Boscalid\Deem Files\Boscalid.R98           Chemical:
BAS 510F

RfD(Chronic): .218 mg/kg bw/day  NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 0 mg/kg bw/day  NOEL(Acute):  0 mg/kg bw/day

Date created/last modified: 10-20-2006/13:20:49/8          Program ver.
2.03

Comment: The FQPA Safety Factor is 1; therefore, the RfD = the PAD

------------------------------------------------------------------------
--------

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Commodity Name                    (ppm)       #1    #2   

-------- ---- -------------------------------  ----------  ------ ------
 -------

14000030 14   Almond                             0.700000   1.000  1.000
 

14000031 14   Almond-babyfood                    0.700000   1.000  1.000
 

14000040 14   Almond, oil                        0.700000   1.000  1.000
 

14000041 14   Almond, oil-babyfood               0.700000   1.000  1.000
 

04010050 4A   Amaranth, leafy                   60.000000   1.000  1.000
 

11000070 11   Apple, fruit with peel             3.000000   1.000  1.000
 2F6434

11000080 11   Apple, peeled fruit                3.000000   1.000  1.000
 2F6434

11000081 11   Apple, peeled fruit-babyfood       3.000000   1.000  1.000
 2F6434

11000090 11   Apple, dried                       3.000000   8.000  1.000
 2F6434

11000091 11   Apple, dried-babyfood              3.000000   8.000  1.000
 2F6434

11000100 11   Apple, juice                       3.000000   1.300  1.000
 2F6434

11000101 11   Apple, juice-babyfood              3.000000   1.300  1.000
 2F6434

11000110 11   Apple, sauce                       3.000000   1.000  1.000
 2F6434

11000111 11   Apple, sauce-babyfood              3.000000   1.000  1.000
 2F6434

12000120 12   Apricot                            1.700000   1.000  1.000
 

12000121 12   Apricot-babyfood                   1.700000   1.000  1.000
 

12000130 12   Apricot, dried                     1.700000   6.000  1.000
 

12000140 12   Apricot, juice                     1.700000   1.000  1.000
 

12000141 12   Apricot, juice-babyfood            1.700000   1.000  1.000
 

01030150 1CD  Arrowroot, flour                   0.050000   1.000  1.000
 

01030151 1CD  Arrowroot, flour-babyfood          0.050000   1.000  1.000
 

01030170 1CD  Artichoke, Jerusalem               0.050000   1.000  1.000
 

04010180 4A   Arugula                           60.000000   1.000  1.000
 

09020210 9B   Balsam pear                        1.600000   1.000  1.000
 

95000230 O    Banana                             0.200000   1.000  1.000
 

95000231 O    Banana-babyfood                    0.200000   1.000  1.000
 

95000240 O    Banana, dried                      0.200000   3.900  1.000
 

95000241 O    Banana, dried-babyfood             0.200000   3.900  1.000
 

15000250 15   Barley, pearled barley             0.200000   1.000  1.000
 

15000251 15   Barley, pearled barley-babyfood    0.200000   1.000  1.000
 

15000260 15   Barley, flour                      0.200000   1.000  1.000
 

15000261 15   Barley, flour-babyfood             0.200000   1.000  1.000
 

15000270 15   Barley, bran                       0.200000   1.000  1.000
 

06030300 6C   Bean, black, seed                  2.500000   1.000  1.000
 

06020310 6B   Bean, broad, succulent             0.600000   1.000  1.000
 

06030320 6C   Bean, broad, seed                  2.500000   1.000  1.000
 

06020330 6B   Bean, cowpea, succulent            0.100000   1.000  1.000
 

06030340 6C   Bean, cowpea, seed                 0.100000   1.000  1.000
 

06030350 6C   Bean,  great northern, seed        2.500000   1.000  1.000
 

06030360 6C   Bean, kidney, seed                 2.500000   1.000  1.000
 

06020370 6B   Bean, lima, succulent              0.600000   1.000  1.000
 

06030380 6C   Bean, lima, seed                   2.500000   1.000  1.000
 

06030390 6C   Bean, mung, seed                   2.500000   1.000  1.000
 

06030400 6C   Bean, navy, seed                   2.500000   1.000  1.000
 

06030410 6C   Bean, pink, seed                   2.500000   1.000  1.000
 

06030420 6C   Bean, pinto, seed                  2.500000   1.000  1.000
 

06010430 6A   Bean, snap, succulent              1.600000   1.000  1.000
 

06010431 6A   Bean, snap, succulent-babyfood     1.600000   1.000  1.000
 

21000440 M    Beef, meat                         0.100000   1.000  1.000
 

21000441 M    Beef, meat-babyfood                0.100000   1.000  1.000
 

21000450 M    Beef, meat, dried                  0.100000   1.920  1.000
 

21000460 M    Beef, meat byproducts              0.350000   1.000  1.000
 

21000461 M    Beef, meat byproducts-babyfood     0.350000   1.000  1.000
 

21000470 M    Beef, fat                          0.300000   1.000  1.000
 

21000471 M    Beef,fat-babyfood                  0.300000   1.000  1.000
 

21000480 M    Beef, kidney                       0.350000   1.000  1.000
 

21000490 M    Beef, liver                        0.350000   1.000  1.000
 

21000491 M    Beef, liver-babyfood               0.350000   1.000  1.000
 

01010500 1AB  Beet, garden, roots                0.100000   1.000  1.000
 

01010501 1AB  Beet, garden, roots-babyfood       0.100000   1.000  1.000
 

02000510 2    Beet, garden, tops                 0.100000   1.000  1.000
 

01010520 1A   Beet, sugar                        0.100000   1.000  1.000
 

01010521 1A   Beet, sugar-babyfood               0.100000   1.000  1.000
 

01010530 1A   Beet, sugar, molasses              0.100000   1.000  1.000
 

01010531 1A   Beet, sugar, molasses-babyfood     0.100000   1.000  1.000
 

13010550 13A  Blackberry                         3.500000   1.000  1.000
 

13010560 13A  Blackberry, juice                  3.500000   1.000  1.000
 

13010561 13A  Blackberry, juice-babyfood         3.500000   1.000  1.000
 

13020570 13B  Blueberry                          3.500000   1.000  1.000
 

13020571 13B  Blueberry-babyfood                 3.500000   1.000  1.000
 

13010580 13A  Boysenberry                        3.500000   1.000  1.000
 

14000590 14   Brazil nut                         0.700000   1.000  1.000
 

05010610 5A   Broccoli                           3.000000   1.000  1.000
 

05010611 5A   Broccoli-babyfood                  3.000000   1.000  1.000
 

05010620 5A   Broccoli, Chinese                  3.000000   1.000  1.000
 

05020630 5B   Broccoli raab                     18.000000   1.000  1.000
 

05010640 5A   Brussels sprouts                   3.000000   1.000  1.000
 

15000650 15   Buckwheat                          0.200000   1.000  1.000
 

15000660 15   Buckwheat, flour                   0.200000   1.000  1.000
 

01010670 1AB  Burdock                            0.700000   1.000  1.000
 

14000680 14   Butternut                          0.700000   1.000  1.000
 

05010690 5A   Cabbage                            3.000000   1.000  1.000
 

05020700 5B   Cabbage, Chinese, bok choy        18.000000   1.000  1.000
 

05010710 5A   Cabbage, Chinese, napa             3.000000   1.000  1.000
 

05010720 5A   Cabbage, Chinese, mustard          3.000000   1.000  1.000
 

09010750 9A   Cantaloupe                         1.600000   1.000  1.000
 

04020760 4B   Cardoon                           45.000000   1.000  1.000
 

01010780 1AB  Carrot                             0.700000   1.000  1.000
 

01010781 1AB  Carrot-babyfood                    0.700000   1.000  1.000
 

01010790 1AB  Carrot, juice                      0.700000   1.000  1.000
 

09010800 9A   Casaba                             1.600000   1.000  1.000
 

14000810 14   Cashew                             0.700000   1.000  1.000
 

01030820 1CD  Cassava                            0.050000   1.000  1.000
 

01030821 1CD  Cassava-babyfood                   0.050000   1.000  1.000
 

05010830 5A   Cauliflower                        3.000000   1.000  1.000
 

01010840 1AB  Celeriac                           0.700000   1.000  1.000
 

04020850 4B   Celery                            45.000000   1.000  1.000
 

04020851 4B   Celery-babyfood                   45.000000   1.000  1.000
 

04020860 4B   Celery, juice                     45.000000   1.000  1.000
 

04020870 4B   Celtuce                           45.000000   1.000  1.000
 

09020880 9B   Chayote, fruit                     1.600000   1.000  1.000
 

12000900 12   Cherry                             1.700000   1.000  1.000
 

12000901 12   Cherry-babyfood                    1.700000   1.000  1.000
 

12000910 12   Cherry, juice                      1.700000   1.500  1.000
 

12000911 12   Cherry, juice-babyfood             1.700000   1.500  1.000
 

14000920 14   Chestnut                           0.700000   1.000  1.000
 

40000930 P    Chicken, meat                      0.050000   1.000  1.000
 

40000931 P    Chicken, meat-babyfood             0.050000   1.000  1.000
 

40000940 P    Chicken, liver                     0.100000   1.000  1.000
 

40000950 P    Chicken, meat byproducts           0.100000   1.000  1.000
 

40000951 P    Chicken, meat byproducts-babyfoo   0.100000   1.000  1.000
 

40000960 P    Chicken, fat                       0.050000   1.000  1.000
 

40000961 P    Chicken, fat-babyfood              0.050000   1.000  1.000
 

40000970 P    Chicken, skin                      0.100000   1.000  1.000
 

40000971 P    Chicken, skin-babyfood             0.100000   1.000  1.000
 

06030980 6C   Chickpea, seed                     2.500000   1.000  1.000
 

06030981 6C   Chickpea, seed-babyfood            2.500000   1.000  1.000
 

06030990 6C   Chickpea, flour                    2.500000   1.000  1.000
 

01011000 1AB  Chicory, roots                     0.700000   1.000  1.000
 

02001010 2    Chicory, tops                      0.100000   1.000  1.000
 

09021020 9B   Chinese waxgourd                   1.600000   1.000  1.000
 

04011040 4A   Chrysanthemum, garland            60.000000   1.000  1.000
 

05021170 5B   Collards                          18.000000   1.000  1.000
 

15001200 15   Corn, field, flour                 0.200000   1.000  1.000
 

15001201 15   Corn, field, flour-babyfood        0.200000   1.000  1.000
 

15001210 15   Corn, field, meal                  0.200000   1.000  1.000
 

15001211 15   Corn, field, meal-babyfood         0.200000   1.000  1.000
 

15001220 15   Corn, field, bran                  0.200000   1.000  1.000
 

15001230 15   Corn, field, starch                0.200000   1.000  1.000
 

15001231 15   Corn, field, starch-babyfood       0.200000   1.000  1.000
 

15001240 15   Corn, field, syrup                 0.200000   1.500  1.000
 

15001241 15   Corn, field, syrup-babyfood        0.200000   1.500  1.000
 

15001250 15   Corn, field, oil                   0.200000   1.000  1.000
 

15001251 15   Corn, field, oil-babyfood          0.200000   1.000  1.000
 

95001280 O    Cottonseed, oil                    0.050000   1.000  1.000
 

95001281 O    Cottonseed, oil-babyfood           0.050000   1.000  1.000
 

11001290 11   Crabapple                          3.000000   1.000  1.000
 2F6434

04011330 4A   Cress, garden                     60.000000   1.000  1.000
 

04011340 4A   Cress, upland                     60.000000   1.000  1.000
 

09021350 9B   Cucumber                           0.200000   1.000  1.000
 

13021360 13B  Currant                            3.500000   1.000  1.000
 

13021370 13B  Currant, dried                     3.500000   1.000  1.000
 

04011380 4A   Dandelion, leaves                 60.000000   1.000  1.000
 

01031390 1CD  Dasheen, corm                      0.050000   1.000  1.000
 

02001400 2    Dasheen, leaves                    0.100000   1.000  1.000
 

13011420 13A  Dewberry                           3.500000   1.000  1.000
 

70001450 P    Egg, whole                         0.020000   1.000  1.000
 

70001451 P    Egg, whole-babyfood                0.020000   1.000  1.000
 

70001460 P    Egg, white                         0.020000   1.000  1.000
 

70001461 P    Egg, white (solids)-babyfood       0.020000   1.000  1.000
 

70001470 P    Egg, yolk                          0.020000   1.000  1.000
 

70001471 P    Egg, yolk-babyfood                 0.020000   1.000  1.000
 

08001480 8    Eggplant                           1.200000   1.000  1.000
 

13021490 13B  Elderberry                         3.500000   1.000  1.000
 

04011500 4A   Endive                            60.000000   1.000  1.000
 

04021520 4B   Fennel, Florence                  45.000000   1.000  1.000
 

14001550 14   Filbert                            0.700000   1.000  1.000
 

14001560 14   Filbert, oil                       0.700000   1.000  1.000
 

20001630 20   Flaxseed, oil                      3.500000   1.000  1.000
 

03001640 3    Garlic                             3.000000   1.000  1.000
 

03001650 3    Garlic, dried                      3.000000   1.000  1.000
 

03001651 3    Garlic, dried-babyfood             3.000000   1.000  1.000
 

01031660 1CD  Ginger                             0.050000   1.000  1.000
 

01031661 1CD  Ginger-babyfood                    0.050000   1.000  1.000
 

01031670 1CD  Ginger, dried                      0.050000   1.000  1.000
 

01011680 1AB  Ginseng, dried                     0.700000   1.000  1.000
 

23001690 M    Goat, meat                         0.100000   1.000  1.000
 

23001700 M    Goat, meat byproducts              0.350000   1.000  1.000
 

23001710 M    Goat, fat                          0.300000   1.000  1.000
 

23001720 M    Goat, kidney                       0.350000   1.000  1.000
 

23001730 M    Goat, liver                        0.350000   1.000  1.000
 

13021740 13B  Gooseberry                         3.500000   1.000  1.000
 

95001750 O    Grape                              3.500000   1.000  1.000
 

95001760 O    Grape, juice                       3.500000   1.200  1.000
 

95001761 O    Grape, juice-babyfood              3.500000   1.200  1.000
 

95001770 O    Grape, leaves                      3.500000   1.000  1.000
 

95001780 O    Grape, raisin                      8.500000   4.300  1.000
 

95001790 O    Grape, wine and sherry             3.500000   1.000  1.000
 

06031820 6C   Guar, seed                         2.500000   1.000  1.000
 

06031821 6C   Guar, seed-babyfood                2.500000   1.000  1.000
 

14001850 14   Hickory nut                        0.700000   1.000  1.000
 

09011870 9A   Honeydew melon                     1.600000   1.000  1.000
 

95001880 O    Hop                               35.000000   1.000  1.000
 2F6434

24001890 M    Horse, meat                        0.100000   1.000  1.000
 

01011900 1AB  Horseradish                        0.700000   1.000  1.000
 

13021910 13B  Huckleberry                        3.500000   1.000  1.000
 

05021940 5B   Kale                              18.000000   1.000  1.000
 

05011960 5A   Kohlrabi                           3.000000   1.000  1.000
 

03001980 3    Leek                               3.000000   1.000  1.000
 

06032030 6C   Lentil, seed                       2.500000   1.000  1.000
 

04012040 4A   Lettuce, head                      6.500000   1.000  1.000
 

04012050 4A   Lettuce, leaf                     11.000000   1.000  1.000
 

13012080 13A  Loganberry                         3.500000   1.000  1.000
 

11002100 11   Loquat                             3.000000   1.000  1.000
 2F6434

14002130 14   Macadamia nut                      0.700000   1.000  1.000
 

27002220 D    Milk, fat                          0.100000   1.000  1.000
 

27002221 D    Milk, fat - baby food/infant for   0.100000   1.000  1.000
 

27012230 D    Milk, nonfat solids                0.100000   1.000  1.000
 

27012231 D    Milk, nonfat solids-baby food/in   0.100000   1.000  1.000
 

27022240 D    Milk, water                        0.100000   1.000  1.000
 

27022241 D    Milk, water-babyfood/infant form   0.100000   1.000  1.000
 

27032251 D    Milk, sugar (lactose)-baby food/   0.100000   1.000  1.000
 

15002260 15   Millet, grain                      0.200000   1.000  1.000
 

05022290 5B   Mustard greens                    18.000000   1.000  1.000
 

12002300 12   Nectarine                          1.700000   1.000  1.000
 

15002310 15   Oat, bran                          0.200000   1.000  1.000
 

15002320 15   Oat, flour                         0.200000   1.000  1.000
 

15002321 15   Oat, flour-babyfood                0.200000   1.000  1.000
 

15002330 15   Oat, groats/rolled oats            0.200000   1.000  1.000
 

15002331 15   Oat, groats/rolled oats-babyfood   0.200000   1.000  1.000
 

08002340 8    Okra                               1.200000   1.000  1.000
 

03002370 3    Onion, dry bulb                    3.000000   1.000  1.000
 

03002371 3    Onion, dry bulb-babyfood           3.000000   1.000  1.000
 

03002380 3    Onion, dry bulb, dried             3.000000   9.000  1.000
 

03002381 3    Onion, dry bulb, dried-babyfood    3.000000   9.000  1.000
 

03002390 3    Onion, green                       3.000000   1.000  1.000
 

04012480 4A   Parsley, leaves                   60.000000   1.000  1.000
 

01012500 1AB  Parsley, turnip rooted             0.700000   1.000  1.000
 

01012510 1AB  Parsnip                            0.700000   1.000  1.000
 

01012511 1AB  Parsnip-babyfood                   0.700000   1.000  1.000
 

06022550 6B   Pea, succulent                     0.600000   1.000  1.000
 

06022551 6B   Pea, succulent-babyfood            0.600000   1.000  1.000
 

06032560 6C   Pea, dry                           2.500000   1.000  1.000
 

06032561 6C   Pea, dry-babyfood                  2.500000   1.000  1.000
 

06012570 6A   Pea, edible podded, succulent      1.600000   1.000  1.000
 

06032580 6C   Pea, pigeon, seed                  2.500000   1.000  1.000
 

06022590 6B   Pea, pigeon, succulent             0.600000   1.000  1.000
 

12002600 12   Peach                              1.700000   1.000  1.000
 

12002601 12   Peach-babyfood                     1.700000   1.000  1.000
 

12002610 12   Peach, dried                       1.700000   7.000  1.000
 

12002611 12   Peach, dried-babyfood              1.700000   7.000  1.000
 

12002620 12   Peach, juice                       1.700000   1.000  1.000
 

12002621 12   Peach, juice-babyfood              1.700000   1.000  1.000
 

95002630 O    Peanut                             0.050000   1.000  1.000
 

95002640 O    Peanut, butter                     0.050000   1.890  1.000
 

95002650 O    Peanut, oil                        0.150000   1.000  1.000
 

11002660 11   Pear                               3.000000   1.000  1.000
 2F6434

11002661 11   Pear-babyfood                      3.000000   1.000  1.000
 2F6434

11002670 11   Pear, dried                        3.000000   6.250  1.000
 2F6434

11002680 11   Pear, juice                        3.000000   1.000  1.000
 2F6434

11002681 11   Pear, juice-babyfood               3.000000   1.000  1.000
 2F6434

14002690 14   Pecan                              0.700000   1.000  1.000
 

08002700 8    Pepper, bell                       1.200000   1.000  1.000
 

08002701 8    Pepper, bell-babyfood              1.200000   1.000  1.000
 

08002710 8    Pepper, bell, dried                1.200000   1.000  1.000
 

08002711 8    Pepper, bell, dried-babyfood       1.200000   1.000  1.000
 

08002720 8    Pepper, nonbell                    1.200000   1.000  1.000
 

08002721 8    Pepper, nonbell-babyfood           1.200000   1.000  1.000
 

08002730 8    Pepper, nonbell, dried             1.200000   1.000  1.000
 

95002750 O    Peppermint                        30.000000   1.000  1.000
 

95002760 O    Peppermint, oil                   30.000000   1.000  1.000
 

14002820 14   Pistachio                          0.700000   1.000  1.000
 

95002830 O    Plantain                           0.200000   1.000  1.000
 

95002840 O    Plantain, dried                    0.200000   3.900  1.000
 

12002850 12   Plum                               1.700000   1.000  1.000
 

12002851 12   Plum-babyfood                      1.700000   1.000  1.000
 

12002860 12   Plum, prune, fresh                 1.700000   1.000  1.000
 

12002861 12   Plum, prune, fresh-babyfood        1.700000   1.000  1.000
 

12002870 12   Plum, prune, dried                 1.700000   5.000  1.000
 

12002871 12   Plum, prune, dried-babyfood        1.700000   5.000  1.000
 

12002880 12   Plum, prune, juice                 1.700000   1.400  1.000
 

12002881 12   Plum, prune, juice-babyfood        1.700000   1.400  1.000
 

25002900 M    Pork, meat                         0.050000   1.000  1.000
 

25002901 M    Pork, meat-babyfood                0.050000   1.000  1.000
 

25002910 M    Pork, skin                         0.100000   1.000  1.000
 

25002920 M    Pork, meat byproducts              0.100000   1.000  1.000
 

25002921 M    Pork, meat byproducts-babyfood     0.100000   1.000  1.000
 

25002930 M    Pork, fat                          0.100000   1.000  1.000
 

25002931 M    Pork, fat-babyfood                 0.100000   1.000  1.000
 

25002940 M    Pork, kidney                       0.100000   1.000  1.000
 

25002950 M    Pork, liver                        0.100000   1.000  1.000
 

01032960 1C   Potato, chips                      0.050000   1.000  1.000
 

01032970 1C   Potato, dry (granules/ flakes)     0.050000   6.500  1.000
 

01032971 1C   Potato, dry (granules/ flakes)-b   0.050000   6.500  1.000
 

01032980 1C   Potato, flour                      0.050000   1.000  1.000
 

01032981 1C   Potato, flour-babyfood             0.050000   1.000  1.000
 

01032990 1C   Potato, tuber, w/peel              0.050000   1.000  1.000
 

01032991 1C   Potato, tuber, w/peel-babyfood     0.050000   1.000  1.000
 

01033000 1C   Potato, tuber, w/o peel            0.050000   1.000  1.000
 

01033001 1C   Potato, tuber, w/o peel-babyfood   0.050000   1.000  1.000
 

60003010 P    Poultry, other, meat               0.050000   1.000  1.000
 

60003020 P    Poultry, other, liver              0.100000   1.000  1.000
 

60003030 P    Poultry, other, meat byproducts    0.100000   1.000  1.000
 

60003040 P    Poultry, other, fat                0.050000   1.000  1.000
 

60003050 P    Poultry, other, skin               0.100000   1.000  1.000
 

09023080 9B   Pumpkin                            1.600000   1.000  1.000
 

09023090 9B   Pumpkin, seed                      1.600000   1.000  1.000
 

11003100 11   Quince                             3.000000   1.000  1.000
 2F6434

04013130 4A   Radicchio                         60.000000   1.000  1.000
 

01013140 1AB  Radish, roots                      0.100000   1.000  1.000
 

02003150 2    Radish, tops                       0.100000   1.000  1.000
 

01013160 1AB  Radish, Oriental, roots            0.100000   1.000  1.000
 

02003170 2    Radish, Oriental, tops             0.100000   1.000  1.000
 

05023180 5B   Rape greens                       18.000000   1.000  1.000
 

20003190 20   Rapeseed, oil                      5.000000   1.000  1.000
 

20003191 20   Rapeseed, oil-babyfood             5.000000   1.000  1.000
 

13013200 13A  Raspberry                          3.500000   1.000  1.000
 

13013201 13A  Raspberry-babyfood                 3.500000   1.000  1.000
 

13013210 13A  Raspberry, juice                   3.500000   1.000  1.000
 

13013211 13A  Raspberry, juice-babyfood          3.500000   1.000  1.000
 

04023220 4B   Rhubarb                           45.000000   1.000  1.000
 

15003230 15   Rice, white                        0.200000   1.000  1.000
 

15003231 15   Rice, white-babyfood               0.200000   1.000  1.000
 

15003240 15   Rice, brown                        0.200000   1.000  1.000
 

15003241 15   Rice, brown-babyfood               0.200000   1.000  1.000
 

15003250 15   Rice, flour                        0.200000   1.000  1.000
 

15003251 15   Rice, flour-babyfood               0.200000   1.000  1.000
 

15003260 15   Rice, bran                         0.200000   1.000  1.000
 

15003261 15   Rice, bran-babyfood                0.200000   1.000  1.000
 

01013270 1AB  Rutabaga                           0.700000   1.000  1.000
 

15003280 15   Rye, grain                         0.200000   1.000  1.000
 

15003290 15   Rye, flour                         0.200000   1.000  1.000
 

01013310 1AB  Salsify, roots                     0.700000   1.000  1.000
 

02003320 2    Salsify, tops                      0.100000   1.000  1.000
 

03003380 3    Shallot                            3.000000   1.000  1.000
 

26003390 M    Sheep, meat                        0.100000   1.000  1.000
 

26003391 M    Sheep, meat-babyfood               0.100000   1.000  1.000
 

26003400 M    Sheep, meat byproducts             0.350000   1.000  1.000
 

26003410 M    Sheep, fat                         0.300000   1.000  1.000
 

26003411 M    Sheep, fat-babyfood                0.300000   1.000  1.000
 

26003420 M    Sheep, kidney                      0.350000   1.000  1.000
 

26003430 M    Sheep, liver                       0.350000   1.000  1.000
 

15003440 15   Sorghum, grain                     0.200000   1.000  1.000
 

15003450 15   Sorghum, syrup                     0.200000   1.000  1.000
 

06003470 6    Soybean, seed                      0.100000   0.330  1.000
 

06003480 6    Soybean, flour                     0.100000   0.330  1.000
 

06003481 6    Soybean, flour-babyfood            0.100000   0.330  1.000
 

06003490 6    Soybean, soy milk                  2.000000   0.330  1.000
 

06003491 6    Soybean, soy milk-babyfood or in   2.000000   0.330  1.000
 

06003500 6    Soybean, oil                       0.100000   0.330  1.000
 

06003501 6    Soybean, oil-babyfood              0.100000   0.330  1.000
 

95003520 O    Spearmint                         30.000000   1.000  1.000
 

95003530 O    Spearmint, oil                    30.000000   1.000  1.000
 

04013550 4A   Spinach                           60.000000   1.000  1.000
 

04013551 4A   Spinach-babyfood                  60.000000   1.000  1.000
 

09023560 9B   Squash, summer                     1.600000   1.000  1.000
 

09023561 9B   Squash, summer-babyfood            1.600000   1.000  1.000
 

09023570 9B   Squash, winter                     1.600000   1.000  1.000
 

09023571 9B   Squash, winter-babyfood            1.600000   1.000  1.000
 

95003590 O    Strawberry                         4.500000   1.000  1.000
 

95003591 O    Strawberry-babyfood                4.500000   1.000  1.000
 

95003600 O    Strawberry, juice                  4.500000   1.000  1.000
 

95003601 O    Strawberry, juice-babyfood         4.500000   1.000  1.000
 

20003640 20   Sunflower, seed                    0.600000   1.000  1.000
 

20003650 20   Sunflower, oil                     0.600000   1.000  1.000
 

20003651 20   Sunflower, oil-babyfood            0.600000   1.000  1.000
 

01033660 1CD  Sweet potato                       0.050000   1.000  1.000
 

01033661 1CD  Sweet potato-babyfood              0.050000   1.000  1.000
 

04023670 4B   Swiss chard                       45.000000   1.000  1.000
 

10003690 10   Tangerine                          2.000000   1.000  1.000
 04CA21

10003700 10   Tangerine, juice                   2.000000   2.300  1.000
 04CA21

01033710 1CD  Tanier, corm                       0.050000   1.000  1.000
 

08003740 8    Tomatillo                          1.200000   1.000  1.000
 

08003750 8    Tomato                             1.200000   1.000  1.000
 

08003751 8    Tomato-babyfood                    1.200000   1.000  1.000
 

08003760 8    Tomato, paste                      1.200000   5.400  1.000
 

08003761 8    Tomato, paste-babyfood             1.200000   5.400  1.000
 

08003770 8    Tomato, puree                      1.200000   3.300  1.000
 

08003771 8    Tomato, puree-babyfood             1.200000   3.300  1.000
 

08003780 8    Tomato, dried                      1.200000  14.300  1.000
 

08003781 8    Tomato, dried-babyfood             1.200000  14.300  1.000
 

08003790 8    Tomato, juice                      1.200000   1.500  1.000
 

15003810 15   Triticale, flour                   0.200000   1.000  1.000
 

15003811 15   Triticale, flour-babyfood          0.200000   1.000  1.000
 

50003820 P    Turkey, meat                       0.050000   1.000  1.000
 

50003821 P    Turkey, meat-babyfood              0.050000   1.000  1.000
 

50003830 P    Turkey, liver                      0.100000   1.000  1.000
 

50003831 P    Turkey, liver-babyfood             0.100000   1.000  1.000
 

50003840 P    Turkey, meat byproducts            0.100000   1.000  1.000
 

50003841 P    Turkey, meat byproducts-babyfood   0.100000   1.000  1.000
 

50003850 P    Turkey, fat                        0.050000   1.000  1.000
 

50003851 P    Turkey, fat-babyfood               0.050000   1.000  1.000
 

50003860 P    Turkey, skin                       0.100000   1.000  1.000
 

50003861 P    Turkey, skin-babyfood              0.100000   1.000  1.000
 

01033870 1CD  Turmeric                           0.050000   1.000  1.000
 

05023890 5B   Turnip, greens                    18.000000   1.000  1.000
 

01013880 1AB  Turnip, roots                      0.100000   1.000  1.000
 

14003910 14   Walnut                             0.700000   1.000  1.000
 

86010000 O    Water, direct, all sources         0.025770   1.000  1.000
 

86020000 O    Water, indirect, all sources       0.025770   1.000  1.000
 

09013990 9A   Watermelon                         1.600000   1.000  1.000
 

09014000 9A   Watermelon, juice                  1.600000   1.000  1.000
 

15004010 15   Wheat, grain                       0.200000   1.000  1.000
 

15004011 15   Wheat, grain-babyfood              0.200000   1.000  1.000
 

15004020 15   Wheat, flour                       0.200000   1.000  1.000
 

15004021 15   Wheat, flour-babyfood              0.200000   1.000  1.000
 

15004030 15   Wheat, germ                        0.200000   1.000  1.000
 

15004040 15   Wheat, bran                        0.200000   1.000  1.000
 

15004050 15   Wild rice                          0.200000   1.000  1.000
 

01034060 1CD  Yam, true                          0.050000   1.000  1.000
 

01034070 1CD  Yam bean                           0.050000   1.000  1.000
 

Attachment 2: Results of Chronic Dietary Exposure Analysis

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for BAS 510F                         (1994-98
data)

Residue file name: E:\ARIA\Boscalid\Deem Files\Boscalid.R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 10-20-2006/13:24:44     Residue file dated:
10-20-2006/13:20:49/8

Reference dose (RfD, Chronic) = .218 mg/kg bw/day

COMMENT 1: The FQPA Safety Factor is 1; therefore, the RfD = the PAD

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.023311               
10.7%

U.S. Population (spring season)             0.023493               
10.8%

U.S. Population (summer season)             0.022667               
10.4%

U.S. Population (autumn season)             0.023361               
10.7%

U.S. Population (winter season)             0.023758               
10.9%

Northeast region                            0.025479               
11.7%

Midwest region                              0.022512               
10.3%

Southern region                             0.020869                
9.6%

Western region                              0.026098               
12.0%

Hispanics                                   0.023967               
11.0%

Non-hispanic whites                         0.022853               
10.5%

Non-hispanic blacks                         0.022717               
10.4%

Non-hisp/non-white/non-black                0.030953               
14.2%

All infants (< 1 year)                      0.052281               
24.0%

Nursing infants                             0.026364               
12.1%

Non-nursing infants                         0.062120               
28.5%

Children 1-6  yrs                           0.062437               
28.6%

Children 7-12 yrs                           0.026554               
12.2%

Females 13-19 (not preg or nursing)         0.015935                
7.3%

Females 20+ (not preg or nursing)           0.018660                
8.6%

Females 13-50 yrs                           0.018621                
8.5%

Females 13+ (preg/not nursing)              0.017570                
8.1%

Females 13+ (nursing)                       0.022202               
10.2%

Males 13-19 yrs                             0.016629                
7.6%

Males 20+ yrs                               0.017377                
8.0%

Seniors 55+                                 0.019318                
8.9%

Children 1-2 yrs                            0.082483               
37.8%

Children 3-5 yrs                            0.056792               
26.1%

Children 6-12 yrs                           0.028500               
13.1%

Youth 13-19 yrs                             0.016295                
7.5%

Adults 20-49 yrs                            0.017377                
8.0%

Adults 50+ yrs                              0.019261                
8.8%

Females 13-49 yrs                           0.017586                
8.1%

------------------------------------------------------------------------
-------

Bocalid Dietary Exposure Assessment	      

	

 PAGE   

 PAGE   1