Document ID: EPA-HQ-OPP-2007-1106-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2008-12-03T05:00Z

SEQ CHAPTER \h \r 1 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF              

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES 

MEMORANDUM

DATE:  	04-SEP-2008

SUBJECT:	Chlorothalonil:  Chronic Dietary (Food and Drinking Water)
Exposure and Risk Assessment to Support Petition For Tolerances on
Brassica Head and Stem Subgroup 5A, Cucurbit Vegetable Group 9, Fruiting
Vegetable Group 8, Ginseng, Horseradish, Lentil, Lupin, Okra, Persimmon,
Rhubarb, Yam, Lychee, and Starfruit.

PC Code:  081901	DP No.:  353241

Decision No.:  385118	Registration No.:  50534-188

Petition No.:  7E7270	Regulatory Action:  Section 3 Registration

Risk Assessment Type:  Dietary	Case No.:  NA

TXR No.:  NA	CAS No.:  1897-45-6

MRID No.:  NA	40 CFR:  §180.275

FROM:	George F. Kramer, Ph.D., Senior Chemist

Registration Action Branch 1 (RAB1)

Health Effects Division (HED; 7509P)

THROUGH:	W. Cutchin, Chemist

		Felecia Fort, Senior Chemist

Dietary Exposure SAC (7509P)

Dana M. Vogel, Branch Chief

RAB1/HED (7509P)

TO:		George F. Kramer, Ph.D., Risk Assessor

RAB1/HED (7509P)

and

Susan Stanton/Daniel Rosenblatt, PM Team 05

		Fungicide Branch/Registration Division (7505P)

EXECUTIVE SUMMARY

™), Version 2.03, which uses food consumption data from the U.S.
Department of Agriculture’s Continuing Surveys of Food Intakes by
Individuals (CSFII) from 1994-1996 and 1998.  These analyses were
performed to add uses on ginseng, horseradish, lentil, lupin, okra,
persimmon, rhubarb, and yam.  In addition, IR-4 proposes to expand the
existing uses on broccoli, Brussels sprouts, cabbage, and cauliflower to
the Brassica head and stem subgroup (5A), the existing uses on cucumber,
melon, and squash to the cucurbit vegetable group (9), and the existing
uses on tomato to the fruiting vegetable group (8).  RD has also
requested that HED recommend levels for tolerances on lychee and
starfruit in order to alleviate trade irritant issues with the
government of Taiwan.

No toxic effects attributable to a single (i.e., acute) exposure to
chlorothalonil have been identified; therefore, an acute reference dose
(RfD) has not been established for chlorothalonil and an acute dietary
exposure assessment has not been conducted.  Also, since HED has
determined that a non-linear approach to cancer risk assessment is
appropriate, the chronic RfD is considered to be protective for this
effect. 

Chronic Dietary (Food and Drinking Water) Exposure Results and
Characterization

A conservative chronic dietary-exposure assessment was performed using
100% crop treated (CT), tolerance-level residues, and DEEM™ 7.81
default processing factors for all foods except for tomatoes (average
field-trial residues and empirical processing factors used), peppers
(average field-trial residues used), and snap beans (average field-trial
residues used).  Dietary risk estimates were determined considering
exposures from food plus drinking water using estimated drinking water
concentrations (EDWCs) for surface water sources provided by the
Environmental Fate and Effects Division (EFED).  EDWC values were
generated by the PRZM (Pesticide Root Zone Model)-EXAMS (Exposure
Analysis Modeling System) for the FL horseradish application scenario,
since this crop yielded the highest EDWC values.  Ground water sources
were not included, as the EDWCs for this water source are minimal in
comparison to those for surface water.

™ software, dietary exposure is estimated at 0.008587 mg/kg/day for
the U.S. population (43% of the cPAD) and 0.018821 mg/kg/day (94% of the
cPAD) for children 1-2 years old, the population subgroup with the
highest estimated chronic dietary exposure to chlorothalonil. 

I.	INTRODUCTION

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
which HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the PAD.  The PAD is equivalent
to the point of departure (e.g., POD, NOAEL, LOAEL) divided by the
required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  References which
discuss the acute and chronic risk assessments in more detail are
available on the EPA/pesticides web site:  “Available Information on
Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000,
web link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see
SOP 99.6 (20-AUG-1999).

The most-recent dietary risk assessment for chlorothalonil was conducted
by G. Kramer (D332540, 9/14/06).

II.	RESIDUE INFORMATION

Established Tolerances:  Permanent and temporary tolerances have been
established for chlorothalonil and its 4-hydroxy metabolite as listed in
40 CFR 180.275.  Chlorothalonil is registered for use on a number of
agricultural commodities, including almond, almond hulls, apricot,
asparagus, banana, bean (dry), bean (snap, succulent), blueberry,
broccoli, Brussels sprouts, cabbage, carrot, cauliflower, celery, cherry
(sweet and tart), cocoa bean, coffee bean, corn (sweet), cranberry,
cucumber, ginseng, mango, melon, mushroom, nectarine, onion (dry bulb
and green), papaya, parsnip (root), passionfruit, peach, peanut, pepper
(non-bell), pistachio, plum (fresh and prune), potato, pumpkin, soybean,
squash (summer and winter) and tomato.  There are regional registrations
for chlorothalonil on filbert and mint hay.  Finally, there are
tolerances for the 4-hydroxy metabolite on fat, kidney, meat, and meat
byproducts of cattle, goat, hog, horse and sheep and in milk.

Recommended Tolerances:  Based on the residue chemistry data submitted
with the current petition, HED recommended for establishment of the
following tolerances (Table 1) for the residues of chlorothalonil and
its 4-hydroxy metabolite (G. Kramer, DP# 346319):

Table 1.  Tolerance Summary for Chlorothalonil.

Commodity	Established Tolerance (ppm)1	Proposed Tolerance (ppm)
Recommended Tolerance (ppm)	Comments; Correct Commodity Definition

Brassica, head and stem, subgroup 5A	--	5.0	5.0	Tolerance recommendation
is based on residue data translated from broccoli, Brussels sprouts,
cabbage, and cauliflower and pending label revision to specify a 7-day
PHI and a maximum seasonal rate of 8.8 lb ai/A.

Broccoli	5	--	Remove from 180.275(a)(1)	Covered by tolerance for
Brassica head and stem subgroup.

Brussels sprouts	5	--

Cabbage	5	--

Cauliflower	5	--

Cucumber	5	--	Remove from 180.275(a)(1)	Covered by tolerance for
cucurbit vegetable group.

Ginseng	0.102	3.0	4.0	Established tolerance under 180.275(b) should be
removed when 4.0-ppm tolerance is established under 180.275(a)(1).

Horseradish	--	4.0	4.0

	Lentil	--	0.1	0.10	Tolerance recommendation based on residue data
translated from dry bean seed.

Lupin	--	0.1	None	Covered by the established tolerance for dry bean
seed. 

Melon	5	--	Remove from 180.275(a)(1)	Covered by tolerance for cucurbit
vegetable group.

Okra	--	5.0	6.0	Tolerance recommendation based on residue data for
representative crops of fruiting vegetables crop group.

Persimmon	--	1.9	1.5	Tolerance should be established under 40 CFR
§180.275(c) and proposed use should be amended to restrict use to FL
and HI.

Pepper, non-bell	53	--	Remove from 180.275(a)(1)	Covered by tolerance
for fruiting vegetable crop group.

Pumpkin	5	--	Remove from 180.275(a)(1)	Covered by tolerance for cucurbit
vegetable group.

Rhubarb	--	5.0	4.0

	Squash, summer	5	--	Remove from 180.275(a)(1)	Covered by tolerance for
cucurbit vegetable group.

Squash, winter	5	--

Tomato	5

5.0

	Vegetable, cucurbit, group 9	--	5.0	5.0	Tolerance recommendation is
based on residue data for cucumber, melon, summer squash, and winter
squash.

Vegetables, fruiting, group 8	--	5.0	6.0	Tolerance recommendation is
based on residue data for bell pepper.

Vegetable, fruiting, group 8, except tomato

Yam	--	5.0	0.10	Tolerance recommendation is based on residue data
translated from potato.

Lychee 	--	--	15	Translated from papaya.

Starfruit	--	--	3.0	Translated from passionfruit.

1  Established under 40 CFR §180.275(a)(1) unless otherwise specified.

2  Established under 40 CFR §180.275(b). 

3  No U.S. registrations as of January 2001.

Anticipated Residues:  The chronic dietary-exposure assessment was
performed using tolerance-level residues for all foods except for
tomatoes, which used an average field-trial residue of 1.24 ppm (MRIDs
00141398, 40000108, and 40000109); peppers , which used an average
field-trial residue of 1.48 ppm for bell pepper and 1.03 ppm for
non-bell pepper (G. Kramer, DP# 346319); and snap beans, which used an
average field-trial residue of 1.8 ppm (J. Tomerlin, 12/15/04; DP#
310791).  DEEM™ 7.81 default processing factors were used for all
foods except for tomatoes, which used empirical processing factors of
0.02 for tomato paste and puree and 0.25 for tomato juice (J. Tomerlin,
12/15/04; DP# 310791).  

III. Drinking Water Data

™ into the food categories “water, direct, all sources” and
“water, indirect, all sources” for the chronic assessment.

Table 2.  Maximum EDWCs for Drinking Water Assessment Based on Aerial
Application of Chlorothalonil.

DRINKING WATER SOURCE (MODEL USED) 	USE (rate modeled)	MAXIMUM EDWC
(ppb) 

Groundwater (SCIGROW)	FL Horseradish  

(8 app. at 2.25 lbs. ai/A)	Chronic	3.2

Surface Water (PRZM/EXAMS)	FL Horseradish  

(8 app. at 2.25 lbs. ai/A)	Chronic	68.2

IV.	DEEM-FCID™ PROGRAM AND CONSUMPTION INFORMATION

A chlorothalonil chronic dietary risk assessment was conducted using
DEEM-FCID™, Version 2.03, which incorporates consumption data from
USDA’s CSFII, 1994-1996 and 1998.  The 1994-96, 98 data are based on
the reported consumption of more than 20,000 individuals over two
non-consecutive survey days.  Foods “as consumed” (e.g., apple pie)
are linked to EPA-defined food commodities (e.g. apples, peeled fruit -
cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S,
baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA.  Consumption data are averaged for the
entire U.S. population and within population subgroups for chronic
exposure assessment, but are retained as individual consumption events
for acute exposure assessment.

The DEEM-FCID™ analysis evaluated the individual food consumption as
reported by respondents in the USDA 1994–1996 and 1998 nationwide
CSFII and accumulated exposure to the chemical for each commodity.  

For chronic exposure and risk assessment, an estimate of the residue
level in each food or food-form (e.g., cranberry or cranberry juice) on
the food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form.  The resulting residue
consumption estimate for each food/food form is summed with the residue
consumption estimates for all other food/food forms on the commodity
residue list to arrive at the total average estimated exposure. 
Exposure is expressed in mg/kg body weight/day and as a percent of the
cPAD.  This procedure is performed for each population subgroup.

V.	TOXICOLOGICAL INFORMATION

A summary of the toxicological endpoints and doses chosen for the
relevant exposure scenarios for human risk assessment are found in Table
3.

Table 3.  Summary of Toxicological Doses and Endpoints for
Chlorothalonil Used in Human-Health Risk Assessments.

Exposure Scenario	

Dose Used in Risk Assessment, UF	

FQPA SF1 and Level of Concern for Risk Assessment	

Study and Toxicological Effects

Acute Dietary-

general population, including infants and children	N/A

	N/A	An endpoint of concern (effect) attributable to a single dose was
not identified in the database.  Quantification of acute risk to general
population including infants and children is not required.

Acute Dietary-

females 13-49 years old	N/A

	N/A	An endpoint of concern (effect) attributable to a single dose was
not identified in the database.  Quantification of acute risk to females
13-49 years old is not required.

Chronic Dietary-

general population, including infants and children	NOAEL = 2.0 mg/kg/day

UF = 100

Chronic RfD = 0.02mg/kg/day	FQPA SF = 1X

cPAD = NOAEL/PAD SF

 = 0.02 mg/kg/day	Chronic toxicity - rat

LOAEL = 4.0 mg/kg/day, based on epithelial cell hyperplasia, clear cell
hyperplasia and karyomegaly in the kidneys of male rats.

Cancer (oral, dermal, inhalation)	Classification:  “Likely” to be a
human carcinogen by all routes of exposure (HED CPRC, 4th Meeting,
6/11/1997); however, the SAP decision (6/30/98) supports the use of an
MOE approach in risk assessment for chlorothalonil.

UF = uncertainty factor, FQPA SF = FQPA Safety Factor, NOAEL =
no-observed-adverse-effect level, LOAEL = lowest-observed-adverse-effect
level, RfD = reference dose (a = acute, c = chronic), PAD =
population-adjusted dose, MOE = margin of exposure, LOC = level of
concern, N/A = Not Applicable

VI.	RESULTS/DISCUSSION AND CONCLUSIONS

™ analyses estimate the dietary exposure of the U.S. population and
various population subgroups.  The results reported in Table 4 are for
the general U.S. Population, all infants (<1 year old), children 1-2,
children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49,
and adults 50+ years.  

A conservative chronic dietary-exposure assessment was performed using
100% CT, tolerance-level residues, and DEEM™ 7.81 default processing
factors for all foods except for tomatoes (average field-trial residues
and empirical processing factors used), peppers (average field-trial
residues used), and snap beans (average field-trial residues used). 
Chlorothalonil chronic dietary (food + water) exposure estimates using
the DEEM-FCID™ software are below HED’s level of concern for the
U.S. population and each of the population subgroups.  Dietary exposure
was estimated at 0.008587 mg/kg/day for the U.S. population (43% of the
cPAD) and 0.018821 mg/kg/day (94% of the cPAD) for children 1-2 years
old, the population subgroup with the highest estimated chronic dietary
exposure to chlorothalonil.  The estimated exposures/risks for combined
food and water are summarized in Table 4 for all populations.

Table 4.  Summary of Chronic Dietary Exposure and Risk for
Chlorothalonil (Food + Water).

Age Group	cPAD (mg/kg/day)	Exposure (mg/kg/day)	% cPAD

	General U.S. Population	0.02	0.008587	43

All Infants (<1 year old)	0.02	0.013143	66

Children 1-2 years old	0.02	0.018821	94

Children 3-5 years old	0.02	0.015688	78

Children 6-12 years old	0.02	0.010345	52

Youth 13-19 years old	0.02	0.006171	31

Adults 20-49 years old	0.02	0.007151	36

Adults 50+ years old	0.02	0.008517	43

Females 13-49 years old	0.02	0.007187	36

VII.	DISCUSSION OF UNCERTAINTIES

These analyses are considered to be very conservative dietary exposure
assessments.  Residues in most foods were assumed to be equivalent to
the tolerance levels.  Tolerance-level residues should always exceed the
residue levels found on food commodities at the time of consumption. 
When field trials are performed, the maximum allowable application rate
is used and crops are harvested at the minimum PHI.  Samples are stored
frozen until analysis to ensure minimal degradation of residues.  In
actual practice, however, growers will not usually use the maximum
application rates for economic reasons.  In addition, most crops are not
harvested and immediately stored frozen.  Also, 100% CT was assumed. 
For these reasons, HED is confident that this analysis does not
underestimate risk to the general U.S. population or any population
subgroup.  Further refinement to the analyses could be made through the
use of anticipated residues, empirical processing factors, and
incorporation of percentages of crops treated with chlorothalonil. 
Since risk estimates are not of concern to HED, a more highly refined
analysis is not needed at this time.

VIII.		LIST OF ATTACHMENTS

Attachment 1- Residue Inputs for Chronic Dietary Assessment of
Chlorothalonil

Attachment 2 - Results of Refined Chronic Dietary Analysis for
Chlorothalonil

cc: G. Kramer (RAB1)

RDI: D. Vogel (9/4/08)

G.F. Kramer:S10781:PY-S:(703)305-5079:7509P:RAB1

Attachment 1- Residue Inputs for Chronic Dietary Assessment of
Chlorothalonil

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for CHLOROTHALONIL                    
1994-98 data

Residue file: C:\Documents and
Settings\gkramer\GK\CHLOROTHALONIL\081901chronic.R98

                                                               Adjust.
#2 used

Analysis Date 07-18-2008             Residue file dated:
07-18-2008/10:32:20/8

Reference dose (RfD) = 0.02 mg/kg bw/day

Comment:Values taken from FR 66(48):14330-14442, Mar 12, 2001

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- -------------------------------   ---------- ------    
------   -------

14000030 14   Almond                             0.050000   1.000     
1.000   

14000031 14   Almond-babyfood                    0.050000   1.000     
1.000   

14000040 14   Almond, oil                        0.050000   1.000     
1.000   

14000041 14   Almond, oil-babyfood               0.050000   1.000     
1.000   

12000120 12   Apricot                            0.500000   1.000     
1.000   

12000121 12   Apricot-babyfood                   0.500000   1.000     
1.000   

12000130 12   Apricot, dried                     0.500000   6.000     
1.000   

12000140 12   Apricot, juice                     0.500000   1.000     
1.000   

12000141 12   Apricot, juice-babyfood            0.500000   1.000     
1.000   

95000190 O    Asparagus                          0.100000   1.000     
1.000   

09020210 9B   Balsam pear                        5.000000   1.000     
1.000   

95000230 O    Banana                             0.500000   1.000     
1.000   

95000231 O    Banana-babyfood                    0.500000   1.000     
1.000   

95000240 O    Banana, dried                      0.500000   3.900     
1.000   

95000241 O    Banana, dried-babyfood             0.500000   3.900     
1.000   

06030300 6C   Bean, black, seed                  0.100000   1.000     
1.000   

06030320 6C   Bean, broad, seed                  0.100000   1.000     
1.000   

06030340 6C   Bean, cowpea, seed                 0.100000   1.000     
1.000   

06030350 6C   Bean,  great northern, seed        0.100000   1.000     
1.000   

06030360 6C   Bean, kidney, seed                 0.100000   1.000     
1.000   

06030380 6C   Bean, lima, seed                   0.100000   1.000     
1.000   

06030390 6C   Bean, mung, seed                   0.100000   1.000     
1.000   

06030400 6C   Bean, navy, seed                   0.100000   1.000     
1.000   

06030410 6C   Bean, pink, seed                   0.100000   1.000     
1.000   

06030420 6C   Bean, pinto, seed                  0.100000   1.000     
1.000   

06010430 6A   Bean, snap, succulent              1.800000   1.000     
1.000   

06010431 6A   Bean, snap, succulent-babyfood     1.800000   1.000     
1.000   

21000440 M    Beef, meat                         0.030000   1.000     
1.000   

21000441 M    Beef, meat-babyfood                0.030000   1.000     
1.000   

21000450 M    Beef, meat, dried                  0.030000   1.920     
1.000   

21000460 M    Beef, meat byproducts              0.050000   1.000     
1.000   

21000461 M    Beef, meat byproducts-babyfood     0.050000   1.000     
1.000   

21000470 M    Beef, fat                          0.100000   1.000     
1.000   

21000471 M    Beef,fat-babyfood                  0.100000   1.000     
1.000   

21000480 M    Beef, kidney                       0.500000   1.000     
1.000   

21000490 M    Beef, liver                        0.050000   1.000     
1.000   

21000491 M    Beef, liver-babyfood               0.050000   1.000     
1.000   

13020570 13B  Blueberry                          1.000000   1.000     
1.000   

13020571 13B  Blueberry-babyfood                 1.000000   1.000     
1.000   

05010610 5A   Broccoli                           5.000000   1.000     
1.000   

05010611 5A   Broccoli-babyfood                  5.000000   1.000     
1.000   

05010620 5A   Broccoli, Chinese                  5.000000   1.000     
1.000   

05010640 5A   Brussels sprouts                   5.000000   1.000     
1.000   

05010690 5A   Cabbage                            5.000000   1.000     
1.000   

05020700 5B   Cabbage, Chinese, bok choy         5.000000   1.000     
1.000   

05010710 5A   Cabbage, Chinese, napa             5.000000   1.000     
1.000   

05010720 5A   Cabbage, Chinese, mustard          5.000000   1.000     
1.000   

09010750 9A   Cantaloupe                         5.000000   1.000     
1.000   

01010780 1AB  Carrot                             1.000000   1.000     
1.000   

01010781 1AB  Carrot-babyfood                    1.000000   1.000     
1.000   

09010800 9A   Casaba                             5.000000   1.000     
1.000   

05010830 5A   Cauliflower                        5.000000   1.000     
1.000   

04020850 4B   Celery                            15.000000   1.000     
1.000   

04020851 4B   Celery-babyfood                   15.000000   1.000     
1.000   

04020860 4B   Celery, juice                     15.000000   1.000     
1.000   

09020880 9B   Chayote, fruit                     5.000000   1.000     
1.000   

12000900 12   Cherry                             0.500000   1.000     
1.000   

12000901 12   Cherry-babyfood                    0.500000   1.000     
1.000   

12000910 12   Cherry, juice                      0.500000   1.500     
1.000   

12000911 12   Cherry, juice-babyfood             0.500000   1.500     
1.000   

06030980 6C   Chickpea, seed                     0.100000   1.000     
1.000   

06030981 6C   Chickpea, seed-babyfood            0.100000   1.000     
1.000   

06030990 6C   Chickpea, flour                    0.100000   1.000     
1.000   

09021020 9B   Chinese waxgourd                   5.000000   1.000     
1.000   

95001090 O    Cocoa bean, chocolate              0.050000   1.000     
1.000   

95001100 O    Cocoa bean, powder                 0.050000   1.000     
1.000   

95001150 O    Coffee, roasted bean               0.200000   1.000     
1.000   

95001160 O    Coffee, instant                    0.200000   1.000     
1.000   

15001270 15   Corn, sweet                        1.000000   1.000     
1.000   

15001271 15   Corn, sweet-babyfood               1.000000   1.000     
1.000   

95001300 O    Cranberry                          5.000000   1.000     
1.000   

95001301 O    Cranberry-babyfood                 5.000000   1.000     
1.000   

95001310 O    Cranberry, dried                   5.000000   1.000     
1.000   

95001320 O    Cranberry, juice                   5.000000   1.100     
1.000   

95001321 O    Cranberry, juice-babyfood          5.000000   1.100     
1.000   

09021350 9B   Cucumber                           5.000000   1.000     
1.000   

08001480 8    Eggplant                           6.000000   1.000     
1.000   

14001550 14   Filbert                            0.100000   1.000     
1.000   

14001560 14   Filbert, oil                       0.100000   1.000     
1.000   

01011680 1AB  Ginseng, dried                     4.000000   1.000     
1.000   

23001690 M    Goat, meat                         0.030000   1.000     
1.000   

23001700 M    Goat, meat byproducts              0.050000   1.000     
1.000   

23001710 M    Goat, fat                          0.100000   1.000     
1.000   

23001720 M    Goat, kidney                       0.500000   1.000     
1.000   

23001730 M    Goat, liver                        0.050000   1.000     
1.000   

06031820 6C   Guar, seed                         0.100000   1.000     
1.000   

06031821 6C   Guar, seed-babyfood                0.100000   1.000     
1.000   

09011870 9A   Honeydew melon                     5.000000   1.000     
1.000   

24001890 M    Horse, meat                        0.030000   1.000     
1.000   

01011900 1AB  Horseradish                        4.000000   1.000     
1.000   

05011960 5A   Kohlrabi                           5.000000   1.000     
1.000   

03001980 3    Leek                               5.000000   1.000     
1.000   

06032030 6C   Lentil, seed                       0.100000   1.000     
1.000   

95002110 O    Lychee                            15.000000   1.000     
1.000   

95002120 O    Lychee, dried                     15.000000   1.000     
1.000   

95002150 O    Mango                              1.000000   1.000     
1.000   

95002151 O    Mango-babyfood                     1.000000   1.000     
1.000   

95002160 O    Mango, dried                       1.000000   1.000     
1.000   

95002170 O    Mango, juice                       1.000000   1.000     
1.000   

95002171 O    Mango, juice-babyfood              1.000000   1.000     
1.000   

27002220 D    Milk, fat                          0.100000   1.000     
1.000   

27002221 D    Milk, fat - baby food/infant for   0.100000   1.000     
1.000   

27012230 D    Milk, nonfat solids                0.100000   1.000     
1.000   

27012231 D    Milk, nonfat solids-baby food/in   0.100000   1.000     
1.000   

27022240 D    Milk, water                        0.100000   1.000     
1.000   

27022241 D    Milk, water-babyfood/infant form   0.100000   1.000     
1.000   

27032251 D    Milk, sugar (lactose)-baby food/   0.100000   1.000     
1.000   

95002280 O    Mushroom                           1.000000   1.000     
1.000   

12002300 12   Nectarine                          0.500000   1.000     
1.000   

08002340 8    Okra                               6.000000   1.000     
1.000   

03002370 3    Onion, dry bulb                    0.500000   1.000     
1.000   

03002371 3    Onion, dry bulb-babyfood           0.500000   1.000     
1.000   

03002380 3    Onion, dry bulb, dried             0.500000   9.000     
1.000   

03002381 3    Onion, dry bulb, dried-babyfood    0.500000   9.000     
1.000   

03002390 3    Onion, green                       5.000000   1.000     
1.000   

95002450 O    Papaya                            15.000000   1.000     
1.000   

95002451 O    Papaya-babyfood                   15.000000   1.000     
1.000   

95002460 O    Papaya, dried                     15.000000   1.800     
1.000   

95002470 O    Papaya, juice                     15.000000   1.500     
1.000   

01012510 1AB  Parsnip                            1.000000   1.000     
1.000   

01012511 1AB  Parsnip-babyfood                   1.000000   1.000     
1.000   

95002520 O    Passionfruit                       3.000000   1.000     
1.000   

95002521 O    Passionfruit-babyfood              3.000000   1.000     
1.000   

95002530 O    Passionfruit, juice                3.000000   1.000     
1.000   

95002531 O    Passionfruit, juice-babyfood       3.000000   1.000     
1.000   

06012570 6A   Pea, edible podded, succulent      5.000000   1.000     
1.000   

12002600 12   Peach                              0.500000   1.000     
1.000   

12002601 12   Peach-babyfood                     0.500000   1.000     
1.000   

12002610 12   Peach, dried                       0.500000   7.000     
1.000   

12002611 12   Peach, dried-babyfood              0.500000   7.000     
1.000   

12002620 12   Peach, juice                       0.500000   1.000     
1.000   

12002621 12   Peach, juice-babyfood              0.500000   1.000     
1.000   

95002630 O    Peanut                             0.300000   1.000     
1.000   

95002640 O    Peanut, butter                     0.300000   1.890     
1.000   

95002650 O    Peanut, oil                        0.300000   1.000     
1.000   

08002700 8    Pepper, bell                       1.480000   1.000     
1.000   

08002701 8    Pepper, bell-babyfood              1.480000   1.000     
1.000   

08002710 8    Pepper, bell, dried                1.480000   1.000     
1.000   

08002711 8    Pepper, bell, dried-babyfood       1.480000   1.000     
1.000   

08002720 8    Pepper, nonbell                    1.030000   1.000     
1.000   

08002721 8    Pepper, nonbell-babyfood           1.030000   1.000     
1.000   

08002730 8    Pepper, nonbell, dried             1.030000   1.000     
1.000   

95002770 O    Persimmon                          1.500000   1.000     
1.000   

14002820 14   Pistachio                          0.200000   1.000     
1.000   

95002830 O    Plantain                           0.500000   1.000     
1.000   

95002840 O    Plantain, dried                    0.500000   3.900     
1.000   

12002850 12   Plum                               0.200000   1.000     
1.000   

12002851 12   Plum-babyfood                      0.200000   1.000     
1.000   

12002860 12   Plum, prune, fresh                 0.200000   1.000     
1.000   

12002861 12   Plum, prune, fresh-babyfood        0.200000   1.000     
1.000   

12002870 12   Plum, prune, dried                 0.200000   5.000     
1.000   

12002871 12   Plum, prune, dried-babyfood        0.200000   5.000     
1.000   

12002880 12   Plum, prune, juice                 0.200000   1.400     
1.000   

12002881 12   Plum, prune, juice-babyfood        0.200000   1.400     
1.000   

25002900 M    Pork, meat                         0.030000   1.000     
1.000   

25002901 M    Pork, meat-babyfood                0.030000   1.000     
1.000   

25002910 M    Pork, skin                         0.100000   1.000     
1.000   

25002920 M    Pork, meat byproducts              0.050000   1.000     
1.000   

25002921 M    Pork, meat byproducts-babyfood     0.050000   1.000     
1.000   

25002930 M    Pork, fat                          0.100000   1.000     
1.000   

25002931 M    Pork, fat-babyfood                 0.030000   1.000     
1.000   

25002940 M    Pork, kidney                       0.500000   1.000     
1.000   

25002950 M    Pork, liver                        0.050000   1.000     
1.000   

01032960 1C   Potato, chips                      0.100000   1.000     
1.000   

01032970 1C   Potato, dry (granules/ flakes)     0.100000   6.500     
1.000   

01032971 1C   Potato, dry (granules/ flakes)-b   0.100000   6.500     
1.000   

01032980 1C   Potato, flour                      0.100000   6.500     
1.000   

01032981 1C   Potato, flour-babyfood             0.100000   6.500     
1.000   

01032990 1C   Potato, tuber, w/peel              0.100000   1.000     
1.000   

01032991 1C   Potato, tuber, w/peel-babyfood     0.100000   1.000     
1.000   

01033000 1C   Potato, tuber, w/o peel            0.100000   1.000     
1.000   

01033001 1C   Potato, tuber, w/o peel-babyfood   0.100000   1.000     
1.000   

09023080 9B   Pumpkin                            5.000000   1.000     
1.000   

09023090 9B   Pumpkin, seed                      5.000000   1.000     
1.000   

04023220 4B   Rhubarb                            4.000000   1.000     
1.000   

26003390 M    Sheep, meat                        0.030000   1.000     
1.000   

26003391 M    Sheep, meat-babyfood               0.030000   1.000     
1.000   

26003400 M    Sheep, meat byproducts             0.050000   1.000     
1.000   

26003410 M    Sheep, fat                         0.100000   1.000     
1.000   

26003411 M    Sheep, fat-babyfood                0.100000   1.000     
1.000   

26003420 M    Sheep, kidney                      0.500000   1.000     
1.000   

26003430 M    Sheep, liver                       0.050000   1.000     
1.000   

06003470 6    Soybean, seed                      0.200000   1.000     
1.000   

06003480 6    Soybean, flour                     0.200000   1.000     
1.000   

06003481 6    Soybean, flour-babyfood            0.200000   1.000     
1.000   

06003490 6    Soybean, soy milk                  0.200000   1.000     
1.000   

06003491 6    Soybean, soy milk-babyfood or in   0.200000   1.000     
1.000   

06003500 6    Soybean, oil                       0.200000   1.000     
1.000   

06003501 6    Soybean, oil-babyfood              0.200000   1.000     
1.000   

09023560 9B   Squash, summer                     5.000000   1.000     
1.000   

09023561 9B   Squash, summer-babyfood            5.000000   1.000     
1.000   

09023570 9B   Squash, winter                     5.000000   1.000     
1.000   

09023571 9B   Squash, winter-babyfood            5.000000   1.000     
1.000   

95003580 O    Starfruit                          3.000000   1.000     
1.000   

08003740 8    Tomatillo                          5.000000   1.000     
1.000   

08003750 8    Tomato                             1.240000   1.000     
1.000   

08003751 8    Tomato-babyfood                    1.240000   1.000     
1.000   

08003760 8    Tomato, paste                      1.240000   0.020     
1.000   

08003761 8    Tomato, paste-babyfood             1.240000   0.020     
1.000   

08003770 8    Tomato, puree                      1.240000   0.020     
1.000   

08003771 8    Tomato, puree-babyfood             1.240000   0.020     
1.000   

08003780 8    Tomato, dried                      1.240000  14.300     
1.000   

08003781 8    Tomato, dried-babyfood             1.240000  14.300     
1.000   

08003790 8    Tomato, juice                      1.240000   0.250     
1.000   

95003800 O    Tomato, Tree                       5.000000   1.000     
1.000   

86010000 O    Water, direct, all sources         0.068200   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.068200   1.000     
1.000   

09013990 9A   Watermelon                         5.000000   1.000     
1.000   

09014000 9A   Watermelon, juice                  5.000000   1.000     
1.000   

01034060 1CD  Yam, true                          0.100000   1.000     
1.000   

Attachment 2 - Results of Chronic Dietary Analysis for Chlorothalonil

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for CHLOROTHALONIL                   (1994-98
data)

Residue file name: C:\Documents and
Settings\gkramer\GK\CHLOROTHALONIL\081901chronic.R98

                                                     Adjustment factor
#2 used.

Analysis Date 07-18-2008/10:32:47     Residue file dated:
07-18-2008/10:32:20/8

Reference dose (RfD, Chronic) = .02 mg/kg bw/day

COMMENT 1: Values taken from FR 66(48):14330-14442, Mar 12, 2001

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of 
ഠ†††††匠扵牧畯⁰†††††††††††潢祤
眠⽴慤⁹††††††晒⁤†††ⴍⴭⴭⴭⴭⴭⴭⴭⴭ
ⴭⴭⴭⴭⴭⴭⴭⴭⴭⴭ‭†ⴭⴭⴭⴭⴭⴭ‭†††ⴭⴭ
ⴭⴭⴭⴭⴭഭ⹕⹓倠灯汵瑡潩⁮琨瑯污 ††††††
††††⸰〰㔸㜸††††††††㈴㤮ഥ

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U.S. Population (spring season)             0.008711               
43.6%

U.S. Population (summer season)             0.010576               
52.9%

U.S. Population (autumn season)             0.007724               
38.6%

U.S. Population (winter season)             0.007290               
36.5%

Northeast region                            0.008913               
44.6%

Midwest region                              0.008388               
41.9%

Southern region                             0.007661               
38.3%

Western region                              0.009976               
49.9%

Hispanics                                   0.009442               
47.2%

Non-hispanic whites                         0.008337               
41.7%

Non-hispanic blacks                         0.007546               
37.7%

Non-hisp/non-white/non-black                0.013606               
68.0%

All infants (< 1 year)                      0.013143               
65.7%

Nursing infants                             0.007202               
36.0%

Non-nursing infants                         0.015398               
77.0%

Children 1-6  yrs                           0.016317               
81.6%

Children 7-12 yrs                           0.009832               
49.2%

Females 13-19 (not preg or nursing)         0.005701               
28.5%

Females 20+ (not preg or nursing)           0.007962               
39.8%

Females 13-50 yrs                           0.007585               
37.9%

Females 13+ (preg/not nursing)              0.008837               
44.2%

Females 13+ (nursing)                       0.010550               
52.7%

Males 13-19 yrs                             0.006609               
33.0%

Males 20+ yrs                               0.007249               
36.2%

Seniors 55+                                 0.008661               
43.3%

Children 1-2 yrs                            0.018821               
94.1%

Children 3-5 yrs                            0.015688               
78.4%

Children 6-12 yrs                           0.010345               
51.7%

Youth 13-19 yrs                             0.006171               
30.9%

Adults 20-49 yrs                            0.007151               
35.8%

Adults 50+ yrs                              0.008517               
42.6%

Females 13-49 yrs                           0.007187               
35.9%

------------------------------------------------------------------------
-------

Chlorothalonil	Dietary Exposure Assessment		DP# 327261

Chlorothalonil	Dietary Exposure and Risk Assessment		DP# 353241

Page   PAGE  2  of   NUMPAGES  12 

Chlorothalonil	Dietary Exposure and Risk Assessment		DP# 327261

Chlorothalonil	Dietary Exposure and Risk Assessment		DP# 327261

Page   PAGE  12  of   NUMPAGES  12