Document ID: EPA-HQ-OPP-2007-0325-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2008-04-02T04:00Z

SEQ CHAPTER \h \r 1 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF              

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES 

MEMORANDUM

DATE:  		16-JAN-2008  

SUBJECT:		Dicamba:  Acute and Chronic Aggregate Dietary (Food and
Drinking Water) Exposure and Risk Assessments for the Proposed Section 3
Registration Action on Sweet Corn.

	PC Code:	029801		Decision#:	304187

	DP#:		347355			 

REVIEWER:		Sarah J. Levy, Chemist

Registration Action Branch 1 (RAB1)

Health Effects Division (HED; 7509P)

THROUGH:		Toiya Goodlow, Chemist

David Soderberg, Chemist

Dietary Exposure Science Advisory Council (DESAC)

HED (7509P)

and

George F. Kramer, Ph.D., Senior Chemist

RAB1/HED (7509P)

TO:			Mary Clock-Rust, Risk Assessor

	RAB1/HED (7509P)

and

			Daniel Rosenblatt, Risk Manager (Team 05) 

Registration Division (RD; 7505P)

Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure
and risk assessments were conducted for dicamba using the Dietary
Exposure Evaluation Model (DEEM-FCID™), Version 2.03 which use food
consumption data from the U.S. Department of Agriculture’s Continuing
Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998. 
The analyses were performed to support a Section 3 use request on sweet
corn.  A cancer dietary assessment was not conducted because dicamba was
classified as not likely to be carcinogenic to humans.

 Acute and Chronic Dietary (Food and Drinking Water) Exposure Results
and Characterization

Tolerance-level residues, DEEM( ver. 7.76 default processing factors,
and 100 percent crop treated (%CT) data were used in the acute and
chronic dietary assessments.  For both acute and chronic dietary
assessments, all population subgroups have risk estimates that are below
HED's level of concern.  For the acute assessment, the most highly
exposed population subgroup is all infants (<1 year old; 11% of the aPAD
(acute population-adjusted dose)).  For the chronic assessment, the most
highly exposed population subgroup is children 1-2 years old (6.7% of
the cPAD (chronic population-adjusted dose)).  The use of anticipated
residues (ARs), empirical processing factors, and % crop treated (CT)
would refine further HED’s exposure and risk estimates; however,
refinement are not needed at this time.

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose (i.e., the dose
that HED has concluded will result in no unreasonable adverse health
effects).  This dose is referred to as the population-adjusted dose
(PAD).  The PAD is equivalent to point of departure (POD, NOAEL, LOAEL,
e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  HED is generally
concerned when estimated cancer risk exceeds one in one million.
References which discuss the acute and chronic risk assessments in more
detail are available on the EPA/pesticides web site:  “Available
Information on Assessing Exposure from Pesticides, A User’s Guide,”
21-JUN-2000, web link:      HYPERLINK
"http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf" 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf  ; or see
SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for dicamba was conducted by
Christine Olinger for purposes of the Reregistration Eligibility
Decision (RED) (11-AUG-2005; DP#: 317702).  This document serves as an
update to the dietary assessment for the RED in which sweet corn was not
included.

II.	Residue Information

Interregional Research Project No. 4 (IR-4) previously submitted a
petition (PP#: 0E6209) proposing tolerances for the combined residues of
the herbicide dicamba and its 5-hydroxy (5-OH) metabolite
(3,6-dichloro-5-hydroxy-o-anisic acid) in/on sweet corn forage, fresh,
and stover.  The residue chemistry data were reviewed in conjunction
with this petition in 2001 (Memo, G. Kramer, 26-JUL-2001; DP#: 271606);
however, a dietary assessment that included sweet corn was not conducted
at that time.

Dicamba (2-methoxy-3,6-dichlorobenzoic acid) is a selective benzoic acid
herbicide registered for the control of weeds prior to or before their
emergence.  Different forms of dicamba (acid and salt) have registered
uses on several food/feed crops including asparagus, barley, corn (field
and pop), grasses grown in pasture and rangeland, oats, proso millet,
rye, sorghum, soybeans, sugarcane, and wheat (40 CFR §180.227).  There
are residential uses established for dicamba. The dicamba Registration
Standard was dated 12-AUG-1983, followed by a dicamba Second Round
Review on 24-MAY-1989.  Dicamba is a List A chemical.  HED’s chapter
for the dicamba RED document was issued in 2005 (Memo, C. Olinger,
13-SEP-2005; DP#: 317720).  

The residues of concern were determined previously (Memo, C. Olinger,
13-SEP-2005; DP#: 317720).  The dicamba risk assessment team deems the
conclusions made previously appropriate for the new use as well.  Table
1 is a summary of the residues of concern.  

Table 1.  Residues of Concern in Crops, Livestock, and Drinking Water.

Matrix	Tolerance Expression	Residues for Risk Assessment

Barley, corn, cotton, grasses, oats, proso millet, sorghum, sugarcane,
and wheat	Dicamba + 5-OH dicamba	Dicamba + 5-OH dicamba

Asparagus	Dicamba + DCSA*	Dicamba + DCSA

Soybeans and aspirated grain fractions (AGFs)	Dicamba + 5-OH dicamba +
DCSA	Dicamba + 5-OH dicamba + DCSA

Livestock	Dicamba + DCSA	Dicamba + DCSA

Drinking Water	NA	Dicamba + DCSA

*  DCSA also referred to as 3,6-dichloro-2-hydroxybenzoic acid or as
3,6-dichlorosalicylic acid.

Residue Data used for the Chronic Assessment:

Tolerance-level residues, DEEM( ver. 7.76 default processing factors,
and 100%CT data were used in the acute and chronic dietary assessments. 
The use of ARs, empirical processing factors, and %CT data would refine
further HED’s exposure and risk estimates.  However, refinements of
the dietary exposure estimates are not needed at this time.  As this
document is an update to the last dietary assessment (sweet corn was
included), the residue data used for the RED is included in Table 3 for
informational purposes.  See Table 2 for a summary of the data used in
the acute and chronic assessment.

Table 2.  Data and Residue Estimates Used in the Acute and Chronic
Dietary Analyses.1

RAC	

Data

Source	

Existing Tolerance2 (ppm)	

HED-Recommended or Reassessed Tolerance Level2 (ppm)

Sweet Corn	DP#: 271606	

--

	0.04

Asparagus	Memo, C. Olinger, 11-AUG-2005; DP#: 317702	4.0	4.0

Barley, grain

6.0	6.0

Corn, field, grain

0.50	TBD

Corn, pop, grain

0.50	TBD

Cottonseed

0.50	TBD

Millet, grain

5.0	TBD

Oat, grain

0.50	TBD

Sorghum, grain

3.0	4.0

Sugarcane, cane

0.10	TBD

Sugarcane, molasses

2.0	5.5

Wheat, grain

2.0	TBD

Fat (cattle, goat, hog, horse, sheep)

0.20	0.30

Kidney (cattle, goat, hog, horse, sheep)

1.5	25

Liver (cattle, goat, hog, horse, sheep)

1.5	3.0

Meat (cattle, goat, hog, horse, sheep)

0.20	0.25

Meat byproducts (cattle, goat, hog, horse, sheep)

0.20	3.0

Milk

0.30	0.2

1  100% CT were assumed for all commodities, as well as DEEM( ver. 7.76
default processing values.

2  Bolded value for each RAC was residue value used in the acute/chronic
assessments.



    Drinking Water Data

The drinking water residues used in the dietary risk assessment were
provided by the Environmental Fate and Effects Division (EFED) in a
memorandum by I. Abdel-Saheb (31-MAY-2005; DP#: 317705), and were
estimated using the highest use rate, application to sugarcane at 2.8
lbs ai/A.  Table 3 below provides a summary of the model estimates for
drinking water from surface water sources.  Surface water estimates were
used in acute and chronic food and water dietary exposure assessments. 
For purposes of this assessment, the highest (i.e., most conservative)
values were used for the acute (367 ppb; parent + DCSA (357 µg/L + 10.1
µg/L)) and chronic (13.75 ppb; parent + DCSA (13 µg/L + 0.75 µg/L))
assessments.  The model and its description are available at the EPA
internet site: http://www.epa.gov/oppefed1/ models/water/.

Table 3.  EDWC to Be Used for Exposure to Dicamba Acid, and its
Degradate DCSA in Drinking Water.

Crop

(application method)	

Model EDWCs  (μg/L)

	

Dicamba	

DCSA

	

Acute	

One-in-10-year annual mean	

36 year overall mean	

Acute	

One-in-10-year annual mean	

36 year overall mean

Surface Water

FL-Sugarcane (Ground)	

357	

13	

5.23	

10.1	

0.75	

0.4

FL-Sugarcane (Aerial)	

346	

12.9	

5.38	

10.9	

0.813	

0.47

LA-Sugarcane (Ground)	

233	

9.74	

3.13	

8.79	

0.66	

0.32

LA-Sugarcane (Aerial)	

230	

9.74	

3.44	

9.74	

0.73	

0.39

Note that these estimates assume one application @ 2.8 lb ai/A (parent);
and 0.446 lb ai/A (DCSA) and a crop area factor of 0.87

IV.	DEEM-FCID™ Program and Consumption Information

Dicamba acute and chronic dietary exposure assessments were conducted
using the DEEM-FCID™, Version 2.03 which incorporates consumption data
from USDA’s CSFII, 1994-1996 and 1998.  The 1994-96, 98 data are based
on the reported consumption of more than 20,000 individuals over two
non-consecutive survey days.  Foods “as consumed” (e.g., apple pie)
are linked to EPA-defined food commodities (e.g., apples, peeled fruit -
cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S,
baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA.  For chronic exposure assessment,
consumption data are averaged for the entire U.S. population and within
population subgroups.  Based on analysis of the 1994-96, 98 CSFII
consumption data, which took into account dietary patterns and survey
respondents, HED concluded that it is most appropriate to report risk
for the following population subgroups: the general U.S. population, all
infants (<1 year old), children 1-2, children 3-5, children 6-12, youth
13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

V.	Toxicological Information

Table 4.	Summary of Toxicological Doses and Endpoints for Dicamba for
Use in Dietary Risk Assessments.

Exposure Scenario	

Dose Used in Risk Assessment, UF	

Uncertainty/FQPA Safety Factors and Level of Concern for Risk Assessment

Study and Toxicological Effects

Acute Dietary

(General population including infants and children	

LOAEL = 300 mg/kg/day

UF = 300

Acute RfD = 1 mg/kg/day	

FQPA SF = 1X

aPAD = acute RfD

              UFs

= 1.0 mg/kg/day	

Acute Neurotoxicity Study in Rats

LOAEL = 300 mg/kg/day (LDT) based on clinical signs of neurotoxicity.

Chronic Dietary

(All populations)	

NOAEL= 45 mg/kg/day

UF = 100

Chronic RfD = 

0.45 mg/kg/day	

FQPA SF = 1X

cPAD = 

chronic RfD

UFs

= 0.45 mg/kg/day	

Multi-generation Reproduction Study in Rats

LOAEL=136 mg/kg/day based on impaired pup growth (decreased pup
weights).

The toxicological endpoints used in this assessment are presented in
Table 4, and were selected by the dicamba team in meetings held on
02-AUG-2005 and 04-AUG-2005.  The dicamba risk assessment team confirmed
that the endpoints selected previously remain appropriate.

UF = uncertainty factor, FQPA SF = FQPA safety factor, NOAEL =
no-observed-adverse-effect-level, LOAEL =
lowest-observed-adverse-effect-level,
P䑁㴠瀠灯汵瑡潩⵮摡番瑳摥搠獯⁥愨㴠愠畣整‬⁣‽
档潲楮⥣‬䑌⁔‽潬敷瑳搭獯⁥整瑳摥മ഍䥖म敒畳瑬
⽳楄捳獵楳湯䌯湯汣獵潩獮ഠ

The DEEM-FCID™ analysis estimates the dietary exposure of the U.S.
population and various population subgroups.  The results for the acute
and chronic assessments reported in Tables 4 and 5 are for the U.S.
Population, all infants (<1 year old), children 1-2, children 3-5,
children 6-12, youth 13-19, females 13-49, males 20-49, and adults 50+
years.  A cancer dietary assessment was not conducted because dicamba
was classified as not likely to be carcinogenic to humans.

The acute and chronic dietary exposure assessments (using tolerance
level residues and 100% CT information for all registered and proposed
uses) were conducted for the general U.S. population and various
population subgroups.  Drinking water values were incorporated directly
into the acute and chronic dietary assessments.  These assessments
conclude that the acute and chronic dietary exposure estimates are not
of concern to HED for the general U.S. population or any population
subgroup.  For the acute assessment, the most highly exposed population
subgroup is all infants (<1 year old; 11% of the aPAD).  For the chronic
assessment, the most highly exposed population subgroup is children 1-2
years old (6.7% of the cPAD).  The use of ARs, empirical processing
factors, and %CT data would refine further HED’s exposure and risk
estimates; however, refinements are not needed at this time.

Table 5.  Summary of Dietary Exposure and Risk for Dicamba.

Population Subgroup	Acute Dietary1

(95th Percentile)	Chronic Dietary1

	Dietary Exposure (mg/kg/day)	%aPAD*	Dietary Exposure (mg/kg/day)	%
cPAD*

U.S. Population (total)	0.044066	4.4	0.012091	2.7

All Infants (< 1 year old)	0.109311   	11	0.020233	4.5

Children 1-2 years old	0.076605   	7.6	0.030196	6.7

Children 3-5 years old	0.068164   	6.8	0.027604	6.1

Children 6-12 years old	0.048314   	4.8	0.018991	4.2

Youth 13-19 years old	0.032048   	3.2	0.011752	2.6

Adults 20-49 years old	0.034236   	3.4	0.009961	2.2

Adults 50+ years old	0.026832   	2.7	0.007616	1.7

Females 13-49 years old	0.031439   	3.1	0.008935	2.0

1 Acute dietary endpoint of 1.0 mg/kg/day applies to the general U.S.
population and all population subgroups.  Chronic dietary endpoint of
0.45 mg/kg/day applies to the general U.S. population and all population
subgroups.

*  The highest %aPAD and %cPAD are bolded. 



VII.  List of Attachments

Attachment 1:  DEEM-FCID(  Acute Residue Input File.

Attachment 2:  DEEM-FCID( Acute Results File.

Attachment 1:  DEEM-FCID( Chronic Residue Input File.

Attachment 1:  DEEM-FCID( Chronic Results File.

cc:  S. Levy

RDI: DESAC (03-JAN-2008)

S. Levy:S10953:PY1:(703)305-0783:7590P

Attachment 1:  DEEM-FCID( Acute Residue Input File.

U.S. Environmental Protection Agency                                Ver.
2.02

DEEM-FCID Acute analysis for DICAMBA

Residue file name: C:\Documents and
Settings\slevy\Desktop\029801a_SL.R98

Analysis Date 01-11-2008           Residue file dated:
01-11-2008/13:45:38/8

Reference dose: aRfD = 1 mg/kg bw/day  NOEL = 300 mg/kg bw/day

Comment: Surface Water Tier 1

------------------------------------------------------------------------
-----

  EPA    Crop                                   Def Res     Adj.Factors 
 Comment

  Code    Grp  Food Name                         (ppm)       #1    #2   

-------- ---- ---------------------------  ----------  ------ ------ 
-------

95000190 O    Asparagus                          4.000000   1.000  1.000

15000250 15   Barley, pearled barley             6.000000   1.000  1.000

15000251 15   Barley, pearled barley-babyfood    6.000000   1.000  1.000

15000260 15   Barley, flour                      6.000000   1.000  1.000

15000261 15   Barley, flour-babyfood             6.000000   1.000  1.000

15000270 15   Barley, bran                       6.000000   1.000  1.000

21000440 M    Beef, meat                         0.250000   1.000  1.000

21000441 M    Beef, meat-babyfood                0.250000   1.000  1.000

21000450 M    Beef, meat, dried                  0.250000   1.920  1.000

21000460 M    Beef, meat byproducts              3.000000   1.000  1.000

21000461 M    Beef, meat byproducts-babyfood     3.000000   1.000  1.000

21000470 M    Beef, fat                          0.300000   1.000  1.000

21000471 M    Beef,fat-babyfood                  0.300000   1.000  1.000

21000480 M    Beef, kidney                      25.000000   1.000  1.000

21000490 M    Beef, liver                        3.000000   1.000  1.000

21000491 M    Beef, liver-babyfood               3.000000   1.000  1.000

15001200 15   Corn, field, flour                 0.500000   1.000  1.000

15001201 15   Corn, field, flour-babyfood        0.500000   1.000  1.000

15001210 15   Corn, field, meal                  0.500000   1.000  1.000

15001211 15   Corn, field, meal-babyfood         0.500000   1.000  1.000

15001220 15   Corn, field, bran                  0.500000   1.000  1.000

15001230 15   Corn, field, starch                0.500000   1.000  1.000

15001231 15   Corn, field, starch-babyfood       0.500000   1.000  1.000

15001240 15   Corn, field, syrup                 0.500000   1.500  1.000

15001241 15   Corn, field, syrup-babyfood        0.500000   1.500  1.000

15001250 15   Corn, field, oil                   0.500000   1.000  1.000

15001251 15   Corn, field, oil-babyfood          0.500000   1.000  1.000

15001260 15   Corn, pop                          0.500000   1.000  1.000

15001270 15   Corn, sweet                        0.040000   1.000  1.000

15001271 15   Corn, sweet-babyfood               0.040000   1.000  1.000

95001280 O    Cottonseed, oil                    5.000000   1.000  1.000

95001281 O    Cottonseed, oil-babyfood           5.000000   1.000  1.000

23001690 M    Goat, meat                         0.250000   1.000  1.000

23001700 M    Goat, meat byproducts              3.000000   1.000  1.000

23001710 M    Goat, fat                          0.300000   1.000  1.000

23001720 M    Goat, kidney                      25.000000   1.000  1.000

23001730 M    Goat, liver                        3.000000   1.000  1.000

24001890 M    Horse, meat                        0.250000   1.000  1.000

27002220 D    Milk, fat                          0.200000   1.000  1.000

27002221 D    Milk, fat - baby food/infant for   0.200000   1.000  1.000

27012230 D    Milk, nonfat solids                0.200000   1.000  1.000

27012231 D    Milk, nonfat solids-baby food/in   0.200000   1.000  1.000

27022240 D    Milk, water                        0.200000   1.000  1.000

27022241 D    Milk, water-babyfood/infant form   0.200000   1.000  1.000

27032251 D    Milk, sugar (lactose)-baby food/   0.200000   1.000  1.000

15002260 15   Millet, grain                      0.500000   1.000  1.000

15002310 15   Oat, bran                          0.500000   1.000  1.000

15002320 15   Oat, flour                         0.500000   1.000  1.000

15002321 15   Oat, flour-babyfood                0.500000   1.000  1.000

15002330 15   Oat, groats/rolled oats            0.500000   1.000  1.000

15002331 15   Oat, groats/rolled oats-babyfood   0.500000   1.000  1.000

25002900 M    Pork, meat                         0.250000   1.000  1.000

25002901 M    Pork, meat-babyfood                0.250000   1.000  1.000

25002910 M    Pork, skin                         0.250000   1.000  1.000

25002920 M    Pork, meat byproducts              3.000000   1.000  1.000

25002921 M    Pork, meat byproducts-babyfood     3.000000   1.000  1.000

25002930 M    Pork, fat                          0.300000   1.000  1.000

25002931 M    Pork, fat-babyfood                 0.300000   1.000  1.000

25002940 M    Pork, kidney                      25.000000   1.000  1.000

25002950 M    Pork, liver                        3.000000   1.000  1.000

15003280 15   Rye, grain                         2.000000   1.000  1.000

15003290 15   Rye, flour                         2.000000   1.000  1.000

26003390 M    Sheep, meat                        0.250000   1.000  1.000

26003391 M    Sheep, meat-babyfood               0.250000   1.000  1.000

26003400 M    Sheep, meat byproducts             3.000000   1.000  1.000

26003410 M    Sheep, fat                         0.300000   1.000  1.000

26003411 M    Sheep, fat-babyfood                0.300000   1.000  1.000

26003420 M    Sheep, kidney                     25.000000   1.000  1.000

26003430 M    Sheep, liver                       3.000000   1.000  1.000

15003440 15   Sorghum, grain                     4.000000   1.000  1.000

15003450 15   Sorghum, syrup                     4.000000   1.000  1.000

06003470 6    Soybean, seed                     10.000000   1.000  1.000

06003480 6    Soybean, flour                    10.000000   1.000  1.000

06003481 6    Soybean, flour-babyfood           10.000000   1.000  1.000

06003490 6    Soybean, soy milk                 10.000000   1.000  1.000

06003491 6    Soybean, soy milk-babyfood or in  10.000000   1.000  1.000

06003500 6    Soybean, oil                      10.000000   1.000  1.000

06003501 6    Soybean, oil-babyfood             10.000000   1.000  1.000

95003620 O    Sugarcane, sugar                   0.100000   1.000  1.000

95003621 O    Sugarcane, sugar-babyfood          0.100000   1.000  1.000

95003630 O    Sugarcane, molasses                5.000000   1.000  1.000

95003631 O    Sugarcane, molasses-babyfood       5.000000   1.000  1.000

86010000 O    Water, direct, all sources         0.367000   1.000  1.000

86020000 O    Water, indirect, all sources       0.367000   1.000  1.000

15004010 15   Wheat, grain                       2.000000   1.000  1.000

15004011 15   Wheat, grain-babyfood              2.000000   1.000  1.000

15004020 15   Wheat, flour                       2.000000   1.000  1.000

15004021 15   Wheat, flour-babyfood              2.000000   1.000  1.000

15004030 15   Wheat, germ                        2.000000   1.000  1.000

15004040 15   Wheat, bran                        2.000000   1.000  1.000

Attachment 2:  DEEM-FCID( Acute Results File.

U.S. Environmental Protection Agency                                Ver.
2.02

DEEM-FCID ACUTE Analysis for DICAMBA                           (1994-98
data)

Residue file: 029801a_SL.R98                      Adjustment factor #2
used.

Analysis Date: 01-11-2008/13:50:09  Residue file dated:
01-11-2008/13:45:38/8

NOEL (Acute) = 300.000000 mg/kg body-wt/day

Daily totals for food and foodform consumption used.

Run Comment: "Surface Water Tier 1"

========================================================================
=====

Summary calculations (per capita):

    95th Percentile             99th Percentile             99.9th
Percentile

Exposure  %aRfD   MOE    Exposure  %aRfD     MOE    Exposure  %aRfD    
MOE  

----------- -------- ---------- ------- -------- ---------- -------
--------

U.S. Population:

0.044066   4.41   6808   0.069246   6.92    4332    0.121895   12.19   
2461  

All infants:

0.109311   10.93  2744   0.163853   16.39   1830    0.239661   23.97   
1251  

Children 1-2 yrs:

0.076605   7.66   3916   0.105629  10.56    2840    0.463867   46.39    
646  

Children 3-5 yrs:

0.068164   6.82   4401   0.092946   9.29    3227    0.360642   36.06    
831  

Children 6-12 yrs:

0.048314   4.83   6209   0.066940   6.69    4481    0.098919    9.89   
3032  

Youth 13-19 yrs:

0.032048   3.20   9360   0.049258   4.93    6090    0.072574    7.26   
4133  

Adults 20-49 yrs:

0.034236   3.42   8762   0.051533   5.15    5821    0.084585    8.46   
3546  

Adults 50+ yrs:

0.026832   2.68   11180  0.036459   3.65    8228    0.061465    6.15   
4880  

Females 13-49 yrs:

0.031439   3.14   9542   0.046573   4.66    6441    0.078833    7.88   
3805  

Attachment 3:  DEEM-FCID( Chronic Residue Input File.

U.S. Environmental Protection Agency                                Ver.
2.00

DEEM-FCID Chronic analysis for DICAMBA                           1994-98
data

Residue file: C:\Documents and Settings\slevy\Desktop\029801c_SL.R98

                                                              Adjust. #2
used

Analysis Date 01-11-2008            Residue file dated:
01-09-2008/17:42:28/8

Reference dose (RfD) = 0.45 mg/kg bw/day

Comment:Surface Water Tier 1

------------------------------------------------------------------------
-----

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

-------- ---- ----------------------   ---------- ------     ------  
-------

95000190 O    Asparagus                          4.000000   1.000     
1.000   

15000250 15   Barley, pearled barley             6.000000   1.000     
1.000   

15000251 15   Barley, pearled barley-babyfood    6.000000   1.000     
1.000   

15000260 15   Barley, flour                      6.000000   1.000     
1.000   

15000261 15   Barley, flour-babyfood             6.000000   1.000     
1.000   

15000270 15   Barley, bran                       6.000000   1.000     
1.000   

21000440 M    Beef, meat                         0.250000   1.000     
1.000   

21000441 M    Beef, meat-babyfood                0.250000   1.000     
1.000   

21000450 M    Beef, meat, dried                  0.250000   1.920     
1.000   

21000460 M    Beef, meat byproducts              3.000000   1.000     
1.000   

21000461 M    Beef, meat byproducts-babyfood     3.000000   1.000     
1.000   

21000470 M    Beef, fat                          0.300000   1.000     
1.000   

21000471 M    Beef,fat-babyfood                  0.300000   1.000     
1.000   

21000480 M    Beef, kidney                      25.000000   1.000     
1.000   

21000490 M    Beef, liver                        3.000000   1.000     
1.000   

21000491 M    Beef, liver-babyfood               3.000000   1.000     
1.000   

15001200 15   Corn, field, flour                 0.500000   1.000     
1.000   

15001201 15   Corn, field, flour-babyfood        0.500000   1.000     
1.000   

15001210 15   Corn, field, meal                  0.500000   1.000     
1.000   

15001211 15   Corn, field, meal-babyfood         0.500000   1.000     
1.000   

15001220 15   Corn, field, bran                  0.500000   1.000     
1.000   

15001230 15   Corn, field, starch                0.500000   1.000     
1.000   

15001231 15   Corn, field, starch-babyfood       0.500000   1.000     
1.000   

15001240 15   Corn, field, syrup                 0.500000   1.500     
1.000   

15001241 15   Corn, field, syrup-babyfood        0.500000   1.500     
1.000   

15001250 15   Corn, field, oil                   0.500000   1.000     
1.000   

15001251 15   Corn, field, oil-babyfood          0.500000   1.000     
1.000   

15001260 15   Corn, pop                          0.500000   1.000     
1.000   

15001270 15   Corn, sweet                        0.040000   1.000     
1.000   

15001271 15   Corn, sweet-babyfood               0.040000   1.000     
1.000   

95001280 O    Cottonseed, oil                    5.000000   1.000     
1.000   

95001281 O    Cottonseed, oil-babyfood           5.000000   1.000     
1.000   

23001690 M    Goat, meat                         0.250000   1.000     
1.000   

23001700 M    Goat, meat byproducts              3.000000   1.000     
1.000   

23001710 M    Goat, fat                          0.300000   1.000     
1.000   

23001720 M    Goat, kidney                      25.000000   1.000     
1.000   

23001730 M    Goat, liver                        3.000000   1.000     
1.000   

24001890 M    Horse, meat                        0.250000   1.000     
1.000   

27002220 D    Milk, fat                          0.200000   1.000     
1.000   

27002221 D    Milk, fat - baby food/infant for   0.200000   1.000     
1.000   

27012230 D    Milk, nonfat solids                0.200000   1.000     
1.000   

27012231 D    Milk, nonfat solids-baby food/in   0.200000   1.000     
1.000   

27022240 D    Milk, water                        0.200000   1.000     
1.000   

27022241 D    Milk, water-babyfood/infant form   0.200000   1.000     
1.000   

27032251 D    Milk, sugar (lactose)-baby food/   0.200000   1.000     
1.000   

15002260 15   Millet, grain                      0.500000   1.000     
1.000   

15002310 15   Oat, bran                          0.500000   1.000     
1.000   

15002320 15   Oat, flour                         0.500000   1.000     
1.000   

15002321 15   Oat, flour-babyfood                0.500000   1.000     
1.000   

15002330 15   Oat, groats/rolled oats            0.500000   1.000     
1.000   

15002331 15   Oat, groats/rolled oats-babyfood   0.500000   1.000     
1.000   

25002900 M    Pork, meat                         0.250000   1.000     
1.000   

25002901 M    Pork, meat-babyfood                0.250000   1.000     
1.000   

25002910 M    Pork, skin                         0.250000   1.000     
1.000   

25002920 M    Pork, meat byproducts              3.000000   1.000     
1.000   

25002921 M    Pork, meat byproducts-babyfood     3.000000   1.000     
1.000   

25002930 M    Pork, fat                          0.300000   1.000     
1.000   

25002931 M    Pork, fat-babyfood                 0.300000   1.000     
1.000   

25002940 M    Pork, kidney                      25.000000   1.000     
1.000   

25002950 M    Pork, liver                        3.000000   1.000     
1.000   

15003280 15   Rye, grain                         2.000000   1.000     
1.000   

15003290 15   Rye, flour                         2.000000   1.000     
1.000   

26003390 M    Sheep, meat                        0.250000   1.000     
1.000   

26003391 M    Sheep, meat-babyfood               0.250000   1.000     
1.000   

26003400 M    Sheep, meat byproducts             3.000000   1.000     
1.000   

26003410 M    Sheep, fat                         0.300000   1.000     
1.000   

26003411 M    Sheep, fat-babyfood                0.300000   1.000     
1.000   

26003420 M    Sheep, kidney                     25.000000   1.000     
1.000   

26003430 M    Sheep, liver                       3.000000   1.000     
1.000   

15003440 15   Sorghum, grain                     4.000000   1.000     
1.000   

15003450 15   Sorghum, syrup                     4.000000   1.000     
1.000   

06003470 6    Soybean, seed                     10.000000   1.000     
1.000   

06003480 6    Soybean, flour                    10.000000   1.000     
1.000   

06003481 6    Soybean, flour-babyfood           10.000000   1.000     
1.000   

06003490 6    Soybean, soy milk                 10.000000   1.000     
1.000   

06003491 6    Soybean, soy milk-babyfood or in  10.000000   1.000     
1.000   

06003500 6    Soybean, oil                      10.000000   1.000     
1.000   

06003501 6    Soybean, oil-babyfood             10.000000   1.000     
1.000   

95003620 O    Sugarcane, sugar                   0.100000   1.000     
1.000   

95003621 O    Sugarcane, sugar-babyfood          0.100000   1.000     
1.000   

95003630 O    Sugarcane, molasses                5.000000   1.000     
1.000   

95003631 O    Sugarcane, molasses-babyfood       5.000000   1.000     
1.000   

86010000 O    Water, direct, all sources         0.013750   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.013750   1.000     
1.000   

15004010 15   Wheat, grain                       2.000000   1.000     
1.000   

15004011 15   Wheat, grain-babyfood              2.000000   1.000     
1.000   

15004020 15   Wheat, flour                       2.000000   1.000     
1.000   

15004021 15   Wheat, flour-babyfood              2.000000   1.000     
1.000   

15004030 15   Wheat, germ                        2.000000   1.000     
1.000   

15004040 15   Wheat, bran                        2.000000   1.000     
1.000   

Attachment 4:  DEEM-FCID( Chronic Results File.

U.S. Environmental Protection Agency                                Ver.
2.00

DEEM-FCID Chronic analysis for DICAMBA                         (1994-98
data)

Residue file name: C:\Documents and
Settings\slevy\Desktop\029801c_SL.R98

                                                   Adjustment factor #2
used.

Analysis Date 01-11-2008/13:51:43   Residue file dated:
01-09-2008/17:42:28/8

Reference dose (RfD, Chronic) = .45 mg/kg bw/day

COMMENT 1: Surface Water Tier 1

========================================================================
=====

                    Total exposure by population subgroup

------------------------------------------------------------------------
-----

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.012091                
2.7%

U.S. Population (spring season)             0.012310                
2.7%

U.S. Population (summer season)             0.011903                
2.6%

U.S. Population (autumn season)             0.012049                
2.7%

U.S. Population (winter season)             0.012112                
2.7%

Northeast region                            0.011694                
2.6%

Midwest region                              0.012764                
2.8%

Southern region                             0.011563                
2.6%

Western region                              0.012561                
2.8%

Hispanics                                   0.012258                
2.7%

Non-hispanic whites                         0.012005                
2.7%

Non-hispanic blacks                         0.012049                
2.7%

Non-hisp/non-white/non-black                0.013225                
2.9%

All infants (< 1 year)                      0.020233                
4.5%

Nursing infants                             0.006872                
1.5%

Non-nursing infants                         0.025305                
5.6%

Children 1-6  yrs                           0.027838                
6.2%

Children 7-12 yrs                           0.018123                
4.0%

Females 13-19 (not preg or nursing)         0.010127                
2.3%

Females 20+ (not preg or nursing)           0.007983                
1.8%

Females 13-50 yrs                           0.009554                
2.1%

Females 13+ (preg/not nursing)              0.010157                
2.3%

Females 13+ (nursing)                       0.010602                
2.4%

Males 13-19 yrs                             0.013284                
3.0%

Males 20+ yrs                               0.010271                
2.3%

Seniors 55+                                 0.007457                
1.7%

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ᔀChildren 1-2 yrs                            0.030196                
6.7%

Children 3-5 yrs                            0.027604                
6.1%

Children 6-12 yrs                           0.018991                
4.2%

Youth 13-19 yrs                             0.011752                
2.6%

Adults 20-49 yrs                            0.009961                
2.2%

Adults 50+ yrs                              0.007616                
1.7%

Females 13-49 yrs                           0.008935                
2.0%

Dicamba	               Dietary Exposure and Risk Assessment  	          
               DP#: 347355	

PC Code:  029801

________________________________________________________________________
___________________

Page   PAGE  1  of   NUMPAGES  14 

Dicamba                                    	Dietary Exposure and Risk
Assessment  	                              DP#: 347355

PC Code:  029801

________________________________________________________________________
_____________________