Document ID: EPA-HQ-OPP-2009-0644-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2012-11-28T05:00Z

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                            WASHINGTON, D.C.  20460

                                                                               
                                        OFFICE OF CHEMICAL SAFETY              
                                                       AND POLLUTION PREVENTION

MEMORANDUM

Date:  		7/24/2012

SUBJECT:	Fenpropathrin  Acute Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessment for the Section 3 Registration Action on the Tropical Fruits Guava, Acerola, Feijoa, Jaboticaba, Passionfruit, Starfruit, Wax Jambu, Lychee, Longan, Spanish Lime, Pulasan, Rambutan, Sugar Apple, Atemoya, Biriba, Cherimoya, Custard Apple, Ilama, and Soursop, and a Tolerance Without U.S. Registration on Tea

PC Code:  127901
DP Barcode:  D402246
Decision No.:  417627
Registration No.: 59639-35
Petition:  9E7594
Regulatory Action:  Section 3 Registration
Risk Assessment Type:  Dietary
Case No.:  7601
TXR No.:  NA
CAS No.:  39515-41-8
MRID No.:  NA
40 CFR:  §180.466

		              									
FROM:  	Douglas Dotson, Ph.D., Chemist
		Risk Assessment Branch II
		Health Effects Division (7509P)	
		
THROUGH:	Donna Davis, Chemist
		Sheila Piper, Chemist
		Dietary Exposure Science Advisory Council (DESAC)
		
TO:		Laura Nollen/Barbara Madden, RM Team 5 
      RIMUERB
		Registration Division (7505P)		
		

Executive Summary

An acute aggregate dietary (food and drinking water) exposure and risk assessment was conducted using the Dietary Exposure Evaluation Model DEEM-FCID(TM), Version 2.03 which uses food consumption data from the U.S. Department of Agriculture's (USDA's) Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998.  The analyses were conducted as part of a human health risk assessment for the requested uses of the pyrethroid insecticide, fenpropathrin, on the tropical fruits guava, acerola, feijoa, jaboticaba, passionfruit, starfruit, wax jambu, lychee, longan, Spanish lime, pulasan, rambutan, sugar apple, atemoya, biriba, cherimoya, custard apple, ilama, and soursop.  In addition, the registrant proposed a tolerance without U.S. registration on tea.  These uses are being requested by the Interregional Research Project Number 4 (IR-4).  Tolerances have already been established for the tropical fruits avocado, canistel, mango, papaya, salal, sapodilla, black sapote, mamey sapote, and star apple. 

A chronic dietary exposure assessment was not performed because a chronic dietary endpoint was not selected for fenpropathrin.  A chronic dietary endpoint is not required because repeated exposure to fenpropathrin does not result in a point of departure lower than that resulting from acute exposure.  Therefore, the acute dietary risk assessment is protective of chronic dietary risk.  An assessment for cancer was not performed because fenpropathrin was classified as "not likely to be carcinogenic to humans."  As a result, an acute assessment was the only dietary exposure assessment performed for fenpropathrin.   

The acute dietary endpoint selected for children is the same as that selected for adults.  Decreased motor activity was observed in a motor activity study.  The FQPA Safety Factor was reduced to 1x for adults; however, it was only reduced to 3x for children six years of age or younger.  As a result, the acute population adjusted dose (aPAD) for children (0.017 mg/kg/day) is lower than that for adults (0.05 mg/kg/day).  Initially, an unrefined assessment based on tolerance level residues and 100% crop treated assumptions was performed for fenpropathrin.  There were no risks of concern for youth and adults; however, there were risks of concern for the population subgroups comprised of infants and children.  As a result, the assessment was refined by incorporating distributions of field trial values, Pesticide Data Program (PDP) monitoring data, and estimates of percent crop treated.  For most processed commodities, DEEM default processing factors were used for those commodities for which they were available.  In some cases, empirical processing factors were used.  For drinking water, a very conservative surface water estimated drinking water concentration (EDWC) generated with the FIRST Model was used.  As a result of the fact that many conservative assumptions were made for this assessment, in particular, the use of field trial data (as opposed to monitoring data) for many commodities, HED is confident that the acute dietary exposure assessment significantly overestimates risk to the general U.S. population and all population subgroups.

The acute risk estimates are below HED's level of concern for all population subgroups, including those comprised of infants and children.  Generally, HED is concerned when risk estimates exceed 100% of the population-adjusted dose (PAD).  The acute risk estimate for the general U.S. population is 19% of the aPAD.  The population subgroup with the highest acute dietary risk estimate is Children 3-5, which uses 97% of the aPAD.  As percent crop treated estimates were incorporated into the assessment, the risk estimates are being reported at the 99.9[th] percentile of exposure.

I.   Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide.  For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).  This dose is referred to as the population-adjusted dose (PAD).  The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD.  References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site:  "Available Information on Assessing Exposure from Pesticides, A User's Guide," 21 Jun 2000, web link:  http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20 Aug 1999).

The most recent dietary exposure assessment performed for fenpropathrin was performed in 2008 (D356137, A. Parmar, 11/26/2008).  Then in 2011, HED performed a screening-level cumulative risk assessment for the pyrethroids and pyrethrins as a class (D394576, 10/4/2011, K. Whitby).  This risk assessment included a dietary exposure analysis in which it was concluded that there were no dietary risks of concern for the pyrethroids and pyrethrins.  

II.   Residue Information

HED has determined that the residue of concern in plant and animal commodities for risk assessment is parent fenpropathrin.  Parent compound is also the residue of concern for risk assessment in drinking water.

Proposed Commodities

As stated above, the current tolerance petition includes the tropical fruits guava, acerola, feijoa, jaboticaba, passionfruit, starfruit, wax jambu, lychee, longan, Spanish lime, pulasan, rambutan, sugar apple, atemoya, biriba, cherimoya, custard apple, ilama, and soursop.  In addition, the registrant proposed a tolerance without U.S. registration on tea.  The recommended tolerances for the proposed commodities were used in the assessment.  These tolerances are provided in Table 1, below.

Table 1.  Fenpropathrin:  Recommended Tolerances for Proposed Tropical Fruits and Tea
                                       
                                   Commodity
                                       
                             Recommended Tolerance
                                     (ppm)
Acerola, Feijoa, Guava, Jaboticaba, Passionfruit, Starfruit, Wax jambu
                                      3.0
Longan, Lychee, Pulasan, Rambutan, Spanish lime
                                      7.0
Atemoya, Biriba, Cherimoya, Custard apple, Ilama, Soursop, Sugar apple 
                                      1.5
Tea
                                      2.0
Registered Commodities

For registered commodities, tolerances, distributions of field trial data, and distributions of monitoring data were used.  The use of the various types of data is discussed below.  At times it was necessary to translate data from certain commodities to other commodities.  These data translations were performed according to the standard operating procedures (SOPs) that govern these translations.  Field trial data were translated according to the guidance given in HED SOP 2000.1:  Guidance for Translation of Field Trial Data from Representative Commodities in the Crop Group Regulation to Other Commodities in Each Crop Group/Subgroup.  Monitoring data were translated according to the guidance given in HED SOP 99.3:  Translation of Monitoring Data.

Residue Point Estimates:  Tolerances

Tolerances for fenpropathrin are established in 40CFR §180.466.  In the analysis, tolerance level residues were used for commodities that did not contribute significantly to the risk estimates (i.e., were not "risk drivers").  Tolerance level residues were used for Chinese broccoli, kohlrabi, peas, eggplant, okra, peppers, tomatillo, blended tomato commodities, cantaloupe, casaba melon, honeydew melon, balsam pear, chayote fruit, Chinese waxgourd, pumpkin, citrus citron, citrus hybrids, citrus oil, lemons, limes, orange peel, pummel, crabapple, loquat, quince, boysenberry, dewberry, loganberry, currant, elderberry, gooseberry, avocado, canistel, cherimoya, cottonseed, grape leaves, dried mango, dried papaya, peanuts, mamey sapote, and all tree nuts.

Tolerance level residues were also used for livestock commodities.  In the previous fenpropathrin risk assessment (D313330, D. Dotson, 11/26/2008), HED recommended in favor of reassessed tolerances for cattle, goat, hog, horse, and sheep commodities.  HED recommended that the tolerance for the meat and meat byproducts of cattle, goats, horses, and sheep be reduced to 0.01 ppm.  HED recommended that the tolerance for the fat of these same commodities be reduced to 0.05 ppm.  HED recommended that tolerance for milk fat be reduced to 0.05 ppm (reflecting 0.002 ppm in whole milk).  Finally, HED recommended that the tolerances for hog commodities (fat, meat, and meat byproducts) be removed.  The revisions have not been made to the 40CFR listing for fenpropathrin; however, HED reiterates the need for these changes and has included those reduced levels in this risk assessment.      

Residue Data Distributions

Residue distribution files (RDFs) were generated for the risk drivers.  These RDFs were comprised of either field trial values or PDP monitoring values.  Monitoring data were used when they were available.  When they were not available, field trial values were used.

Field Trial Data

Distributions of field trial values were used for Brussels sprouts, cabbage, Chinese napa cabbage, tomatoes, cucumbers, grapefruit, apricots, cherries, nectarines, peaches, plums, blackberries, raspberries, mango, olive, and papaya.  As stated above, field trial data were translated according to the guidance given in HED SOP 2000.1.  Cabbage field trial data were translated to Brussels sprouts and Chinese napa cabbage.  Peach field trial data were translated to apricots and nectarines.  Finally, avocado field trial data were translated to mango and papaya and guava field trial data were translated to passionfruit.  Tropical fruits are not listed in SOP 2000.1.  However, these fruits are all tropical fruits with inedible peel, and HED believes that these translations are appropriate.

PDP Data

Distributions of monitoring data values were used for broccoli, Chinese mustard cabbage, cauliflower, watermelon, squash, oranges, tangerines, apples, apple juice, pears, blueberries, huckleberries, grapes, grape juice, and strawberries.  Monitoring data from the years 2007 through 2010, inclusive, were used.  As stated above, monitoring data were translated according to the guidance given in HED SOP 99.3.  Broccoli PDP data were translated to Chinese mustard cabbage and cauliflower.  Orange PDP data were translated to tangerines.  Finally, blueberry PDP data were translated to huckleberries.  Bushberries are not listed in SOP 99.3.  However, as blueberries and huckleberries are similar crops and are both in Crop Subgroup 13-07B (Bushberry subgroup), blueberry data were translated to huckleberries.

Residue Data for Blended Commodities

The acute residue input file includes the following blended commodities:  dried bell pepper, dried nonbell pepper, tomato paste, tomato puree, dried tomatoes, pumpkin seed, dried tea, instant tea, peanuts, peanut butter, peanut oil, citrus oil, almond oil, filbert oil, cottonseed oil, olive oil, dried apple, dried pear, dried apricot, dried peach, and dried papaya.  For all of these commodities, a point estimate was used as the residue value.  In most cases, the point estimate was the tolerance.  The average field trial value was used for dried apples, dried pears, and dried peaches.  The average peach field trial value was translated to dried apricots.  For these blended commodities, the percent crop treated estimates were entered directly into the Adjustment Factor 2 column.  Percent crop treated estimates were used for tomato paste, tomato puree, dried tomatoes, dried apples, dried pears, dried apricots, dried peaches, cottonseed oil, and olive oil.

The residue data discussed above are summarized in Attachment 3.

Processing Factors

The processing factors used in the analysis are provided in the previous dietary exposure assessment performed for fenpropathrin (D356137, A. Parmar, 11/26/2008).  These same factors are being used in the current assessment.

The registrant performed processing studies on some of the commodities in the analysis.  Empirical processing factors were used for citrus, grapes, melons, peanuts, apples, plums and tomatoes.  When empirical processing factors were not available, default processing factors from DEEM (Version 7.81) were used.  The DEEM default processing factors were used for dried apples, dried apricots, dried beef, dried papaya, dried peaches, dried pear, peanut butter, cherry juice, papaya juice, and plum juice.  Table 2 below lists the empirical processing factors and the DEEM 7.81 default processing factors that were used in the analyses.  

Table 2:  Processing Factors Used in Fenpropathrin Dietary Exposure Assessment

                                   Commodity

                                    Process

                                    Factor

                                   Reference

Apple

Dried

                                      8.0

DEEM 7.81 Default

Apricot

Dried
                                       
                                      6.0

DEEM 7.81 Default

Beef

Dried
                                       
                                     1.92

DEEM 7.81 Default

Cantaloupe

Peeled

                                     0.02

D257376

Cherry

Juice
                                       
                                      1.5

DEEM 7.81 Default

Citrus

Juice

                                     0.06

D257376

Citrus Peel

Peeling

                                      2.6

D257376

Grapes

Raisins

                                     1.54

D257376

Grapes

Wine

                                     0.003

D257376

Melons (except Watermelon)

Peeling

                                     0.02

D257376

Papaya 

Dried
                                       
                                      1.8

DEEM 7.81 Default

Papaya

Juice
                                       
                                      1.5

DEEM 7.81 Default

Peach

Dried
                                       
                                      7.0

DEEM 7.81 Default

Peanuts

Refined Oil

                                      4.0

D257376

Peanuts

Peanut Butter

                                     1.89

DEEM 7.81 Default

Pear

Dried

                                     6.25

DEEM 7.81 Default

Plum

Juice
                                       
                                      1.4

DEEM 7.81 Default

Plum

Prune (Dried)
                                       
                                      2.6

D333113

Tomatoes

Washing

                                     0.83

D257376

Tomatoes

Juice

                                     0.05

D257376

Tomatoes

Paste

                                      0.3

D257376

Tomatoes - Dried

Washing x Drying

                              0.83 x 14.3 = 11.87

D257376 and DEEM 7.81

Residues in Fish

Fenpropathrin has a low water solubility and a high octanol/water partition coefficient.  As a result, it will not dissolve in water to any significant extent.  Residues have the potential to partition into sediment at the bottoms of water bodies, however.  Catfish are bottom feeders and residues in catfish serve as a marker for pesticide residues.  The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009, and 2010.  Over this 3-year period, PDP analyzed 1,458 samples of catfish for fenpropathrin residues.  None of the samples contained detectable residues.  As a result, residues in fish are not an important issue for fenpropathrin and were not included in the assessment. 

III.   Percent Crop Treated Information

The Biological and Economic Analysis Division (BEAD) provided a Screening Level Usage Analysis (SLUA) for fenpropathrin (D402054, S. Haddad, 5/25/2012).  The SLUA provided maximum percent crop treated estimates for commodities with established tolerances.  The percent crop treated estimates were used to prepare the RDFs for nonblended and partially blended commodities.  For blended commodities, the percent crop treated estimates were entered directly in the Adjustment Factor #2 column in the DEEM input file.  The SLUA is included in this dietary exposure memo in Attachment 5.  Not all of the percent crop treated estimates in the SLUA were used in the assessment.  The values that were used are given in Table 3, below.

Table 3.  Maximum Percent Crop Treated Estimates Used in Acute Dietary Exposure Assessment

                                       
                                   Commodity
                                    Maximum
                                % Crop Treated
                                       
                                   Commodity
                                    Maximum
                                % Crop Treated
Apples
                                      15
Grapes
                                      10
Apricots
                                      2.5
Nectarines
                                      2.5
Blueberries
                                      2.5
Oranges
                                      35
Broccoli
                                      2.5
Peaches
                                      2.5
Brussels Sprouts
                                      10
Pears
                                      10
Cabbage
                                      2.5
Plums/Prunes
                                      2.5
Cauliflower
                                      2.5
Squash
                                      2.5
Cherries
                                       5
Strawberries
                                      50
Cotton
                                      2.5
Tangerines
                                      15
Cucumbers
                                      2.5
Tomatoes
                                      10
Grapefruit
                                      35
Watermelon
                                      2.5

IV.   Drinking Water Data

The Environmental Fate and Effects Division (EFED) provided the results of a drinking water assessment that was performed for fenpropathrin (D368174, Jose Melendez, 4/26/2010).  In this memo, EFED stated that the results of a previous assessment (D313331, J. Melendez, 9/3/2008) should be used in the current dietary exposure analysis.  Water numbers were based on parent only because the degradates occurred at low levels in the laboratory studies.  The EFED memo of 9/03/2008 provided Tier 1 estimated environmental concentrations for fenpropathrin that were calculated using the FIRST Model for surface water and the SCIGROW Model for groundwater.  For surface water, the acute (peak) water concentration is 10.3 ppb.  The groundwater screening concentration is 0.005 ppb.  These values generally represent upper-bound estimates of the concentrations that might be found in surface water and groundwater resulting from the use of fenpropathrin on grapes, because this is the scenario that results in the highest estimated drinking water concentrations (EDWCs).  For the acute dietary exposure assessment, the peak water concentration value of 10.3 ppb was used.  The model and its description are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/.  

V.   DEEM-FCID(TM) Program and Consumption Information

The fenpropathrin acute dietary exposure assessment was conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM-FCID(TM),Version 2.03 which incorporates consumption data from USDA's CSFII, 1994-1996 and 1998.  The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days.  Foods "as consumed" (e.g., apple pie) are linked to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA.  For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events.  Based on analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years old.

For acute exposure assessments, individual one-day food consumption data are used on an individual-by-individual basis.  The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or "matched" in multiple random pairings with residue values and then summed in a probabilistic assessment.  The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis.  In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis.  However, for tiers 1 and 2, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.

VI.   Toxicological Information

Adequate data have been submitted to characterize the toxicity of fenpropathrin for the purposes of dietary risk assessment.  The acute dietary endpoint was based on decreased motor activity seen in a motor activity study.  A chronic dietary endpoint is not required because repeated exposure to fenpropathrin does not result in a lower point of departure.  Therefore, the acute endpoint is protective of chronic exposure scenarios.  The FQPA Safety Factor was reduced to 1x for youth and adults; however, it was reduced to 3x for children 6 years of age and under.  The additional safety factor for children is based on the increased quantitative susceptibility seen in the scientific literature related to pyrethroid pharmacokinetics (D381210, E. Scollon and A. Lowit, 6/27/2011).  In accordance with the EPA's Final Guidelines for Carcinogen Risk Assessment (March, 2005), fenpropathrin was classified as "not likely to be carcinogenic to humans."  The fenpropathrin doses and endpoints for dietary exposure assessment are summarized in Table 4, below.

Table 4.  Summary of Toxicological Doses and Endpoints for Fenpropathrin

                               Exposure Scenario
                       Dose Used in Risk Assessment, UF
                      FQPA SF and LOC for Risk Assessment
                        Study and Toxicological Effects
Acute Dietary-
(>= 6 years old)

Wolansky BMDL1SD = 5.0 mg/kg
UF = 100
Acute RfD =  0.05 mg/kg
FQPA SF =    1X
aPAD = acute RfD
               FQPA SF
  
         =   0.05     mg/kg/day
Wolansky BMD1SD = 6.4 mg/kg
based on decreased motor activity

Acute Dietary-
(< 6 years old)

Wolansky BMDL1SD = 5.0 mg/kg

UF = 100
Acute RfD =  0.05 mg/kg
FQPA SF =    3X

aPAD = acute RfD
               FQPA SF

           =   0.017     mg/kg/day
Wolansky BMD1SD = 6.4 mg/kg
based on decreased motor activity

Chronic Dietary
A chronic dietary endpoint is not required because repeated exposure to fenpropathrin does not result in a lower point of departure.  Therefore, the acute endpoint is protective of chronic exposure scenarios.
Cancer
Classification:    "not likely to be carcinogenic to humans" in accordance with the EPA Final Guidance for Carcinogen Risk Assessment (3/29/05)  
BMDL=Bench Mark Dose Level, 1SD=One Standard Deviation, UF = uncertainty factor, RfD = reference dose, aPAD = acute population adjusted dose

VII.   Results/Discussion 

As stated above, for an acute dietary exposure assessment, HED is concerned when dietary risk exceeds 100% of the aPAD.  The DEEM-FCID(TM) analyses estimate the dietary exposure of the U.S. population and various population subgroups.  The results reported in Table 5 are for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years.  Risk estimates are below HED's level of concern for the general U.S. population and all population subgroups.  The acute risk estimate for the general U.S. population is 19% of the aPAD.  The population subgroup with the highest acute risk estimate is Children 3-5, which uses 97% of the aPAD.  A full listing of the exposure and risk estimates is included in Attachment 2.

Residues in drinking water made a negligible contribution to the risk estimates.  

 
 Table 5.  Summary of the Acute Exposure and Risk Estimates for Fenpropathrin
 
 Population Subgroup
                     Acute Assessment (99.9[th] Percentile)
                               Chronic Assessment
 
                                  aPAD, mg/day
                           Exposure Estimate, mg/day
                                     % aPAD
                                  cPAD, mg/day
                           Exposure Estimate, mg/day
                                     % cPAD
U.S. Population
                                     0.05
0.009489
19
                                      NA
                                       
                                       
                                       
                                       
                                       
                                       
                                      NA

                                       
                                      NA

All infants
                                     0.017
0.011457
67
                                       

Children 1-2 yrs
                                     0.017
0.015343
90
                                       

Children 3-5 yrs*
                                     0.017
0.016488
97
                                       

Children 6-12 yrs
                                     0.05
0.013489
27
                                       

Youth 13-19 yrs
                                     0.05
0.009290
19
                                       

Adults 20-49 yrs
                                     0.05
0.007920
16
                                       

Adults 50+ yrs
                                     0.05
0.008093
16
                                       

Females 13-49 yrs
                                     0.05
0.008476
17
                                       

 *Most highly exposed population subgroup
 
 
 VIII.   Characterization of Inputs/Outputs
 
HED considers the acute assessment to be partially refined, but at the same time, very health-protective.  Refinements were made to most of the risk drivers in the assessment; however, in many cases, these refinements consisted of the incorporation of field trial data.  HED has learned from past experience that monitoring data are often significantly lower than field trial data.  Monitoring data more accurately represent the residue levels to which people will actually be exposed to pesticide residues in their diets.  In 2004, HED compared field trial and monitoring data for the pyrethroids permethrin, lambda cyhalothrin, and esfenvalerate.  For those compounds, the monitoring data were one to two orders of magnitude lower than the field trial data for the same commodities.  If monitoring data were available for more of the risk drivers, particularly stone fruits, raspberries, and blackberries, the risk estimates would have been considerably lower.  The assessment is also conservative in that tolerance level residues were used for many commodities.

Percent crop treated estimates ranged from conservative to moderately refined.  For many commodities, the assumption was made that 100% of the crop would be treated.  For other commodities, maximum percent crop treated estimates were incorporated.  These estimates are based on past usage data and are considered to be very reliable.  Percent crop treated estimates were not available for two of the risk drivers for children 1-6 years of age, raspberries and blackberries.  As a result, 100% crop treated was used for these commodities.  If usage estimates were available and had been used, the risk estimates for the population subgroups, Children 1-2 and Children 3-5, would have been lower.

Processing factors also ranged from conservative to refined.  DEEM default factors were used for some commodities whereas empirical processing factors were used for others.    

The risk estimates would be significantly lower if monitoring data were available for more of the risk drivers in the analysis.  More monitoring data will be available in the future.  The analysis could be refined further by incorporating percent crop treated estimates for new uses.  However, as all risk estimates are not of concern, it is not necessary to make any further refinements to the dietary exposure assessment at this time.  

 IX.   Conclusions
 
The exposure estimates that were generated are refined estimates of the actual dietary exposures that might occur.  The acute aggregate (food + water) dietary risk estimates are below HED's level of concern for the general U.S. population and all population subgroups.  HED is confident that the assessment does not underestimate risk to the general U.S. population or any population subgroup.
 
 
 X.   List of Attachments
 
Attachment 1.  Acute Dietary Residue Input File
Attachment 2.  Results of Acute Dietary Exposure Assessment
 Attachment 3.  Residue Inputs for Individual Commodities
 Attachment 4.  Residue Distribution Files
 Attachment 5.  Screening Level Usage Analysis

Attachment 1:  Fenpropathrin Residue Input File

Acute NOAEL:  5 mg/kg/day
Acute PAD:  0.05 mg/kg/day for Adults, Youth, and Children Over  6 Years of Age
Acute PAD:  0.017 mg/kg/day for Children 6 Years of Age and Under

DEEM-FCID Version 2.03

Filename: C:\Documents and Settings\ddotson\My Documents\DEEM FCID\Fenpropathrin\FenpropAcutePDP.R98

Date created/last modified: 06-10-2012/10:40:51/8

--------------------------------------------------------------------------------
RDL indices and parameters for Monte Carlo Analysis:
Index Dist Parameter #1        Param #2  Param #3  Comment
  #   Code 
----- ---- ------------        --------  --------  -------
  1    6   ApplePDP15pct.RDF
  2    6   PearPDP10pct.RDF
  3    6   GrapePDP10pct.RDF
  4    6   CherryFT5pct.RDF
  5    6   PeachFT2.5pct.RDF
  6    6   PlumFT2.5pct.RDF
  7    6   BroccoliPDP2.5pct.RDF
  8    6   OrangePDP35pct.RDF
  9    6   BlueberryPDP2.5pct.RDF
  10   6   StrawberryPDP50pct.RDF
  11   6   GrapefruitFT35pct.RDF
  12   6   CaneberryFT100pct.RDF
  13   6   Apricot2.5pct.RDF
  14   6   CabbageFT2.5pct.RDF
  15   6   PapayaFT100PctCT.RDF
  16   6   TangerinePDP15Pct.RDF
  17   6   WatermelonPDP2.5pct.RDF
  18   6   OliveFT100PctCT.RDF
  19   6   TomatoFT10pct.RDF
  20   6   CucumberFT2.5PctCT.RDF
  21   6   SquashPDP2.5PctCT.RDF
  22   6   ChineseNapaCabbage.RDF
  23   6   ChineseMustardCabbage.RDF
  24   6   BrusselsFT10PctCT.RDF
  25   6   AppleJuicePDP15pct.RDF
  26   6   GrapeJuicePDP10pct.RDF
  27   6   GuavaFT100pct.RDF

  EPA    Crop Commodity Name                    Def Res     Adj.Factors  RDL  Comment
  Code    Grp                                    (ppm)       #1     #2   Pntr
-------- ---- -------------------------------  ----------  ------ ------ ---  -------
05010610 5A   Broccoli                           3.000000   1.000  1.000   7  
05010611 5A   Broccoli-babyfood                  3.000000   1.000  1.000   7  
05010620 5A   Broccoli, Chinese                  3.000000   1.000  1.000      
05010640 5A   Brussels sprouts                   3.000000   1.000  1.000  24  
05010690 5A   Cabbage                            3.000000   1.000  1.000  14  
05010710 5A   Cabbage, Chinese, napa             3.000000   1.000  1.000  22  
05010720 5A   Cabbage, Chinese, mustard          3.000000   1.000  1.000  23  
05010830 5A   Cauliflower                        3.000000   1.000  1.000   7  
05011960 5A   Kohlrabi                           3.000000   1.000  1.000      
06012570 6A   Pea, edible podded, succulent      0.020000   1.000  1.000      
06022550 6B   Pea, succulent                     0.020000   1.000  1.000      
06022551 6B   Pea, succulent-babyfood            0.020000   1.000  1.000      
06022590 6B   Pea, pigeon, succulent             0.020000   1.000  1.000      
08001480 8    Eggplant                           1.000000   1.000  1.000      
08002340 8    Okra                               1.000000   1.000  1.000      
08002700 8    Pepper, bell                       1.000000   1.000  1.000      
08002701 8    Pepper, bell-babyfood              1.000000   1.000  1.000      
08002710 8    Pepper, bell, dried                1.000000   1.000  1.000      
08002711 8    Pepper, bell, dried-babyfood       1.000000   1.000  1.000      
08002720 8    Pepper, nonbell                    1.000000   1.000  1.000      
08002721 8    Pepper, nonbell-babyfood           1.000000   1.000  1.000      
08002730 8    Pepper, nonbell, dried             1.000000   1.000  1.000      
08003740 8    Tomatillo                          1.000000   1.000  1.000      
08003750 8    Tomato                             1.000000   0.830  1.000  19  
08003751 8    Tomato-babyfood                    1.000000   0.830  1.000  19  
08003760 8    Tomato, paste                      1.000000   0.300  0.100      
08003761 8    Tomato, paste-babyfood             1.000000   0.300  0.100      
08003770 8    Tomato, puree                      1.000000   0.830  0.100      
08003771 8    Tomato, puree-babyfood             1.000000   0.830  0.100      
08003780 8    Tomato, dried                      1.000000  11.870  0.100      
08003781 8    Tomato, dried-babyfood             1.000000  11.870  0.100      
08003790 8    Tomato, juice                      1.000000   0.050  1.000  19  
09010750 9A   Cantaloupe                         0.500000   0.020  1.000      
09010800 9A   Casaba                             0.500000   0.020  1.000      
09011870 9A   Honeydew melon                     0.500000   0.020  1.000      
09013990 9A   Watermelon                         0.500000   1.000  1.000  17  
09014000 9A   Watermelon, juice                  0.500000   1.000  1.000  17  
09020210 9B   Balsam pear                        0.500000   1.000  1.000      
09020880 9B   Chayote, fruit                     0.500000   1.000  1.000      
09021020 9B   Chinese waxgourd                   0.500000   1.000  1.000      
09021350 9B   Cucumber                           0.500000   1.000  1.000  20  
09023080 9B   Pumpkin                            0.500000   1.000  1.000      
09023090 9B   Pumpkin, seed                      0.500000   1.000  1.000      
09023560 9B   Squash, summer                     0.500000   1.000  1.000  21  
09023561 9B   Squash, summer-babyfood            0.500000   1.000  1.000  21  
09023570 9B   Squash, winter                     0.500000   1.000  1.000  21  
09023571 9B   Squash, winter-babyfood            0.500000   1.000  1.000  21  
10001060 10   Citrus citron                      2.000000   1.000  1.000      
10001070 10   Citrus hybrids                     2.000000   1.000  1.000      
10001080 10   Citrus, oil                       75.000000   1.000  1.000      
10001800 10   Grapefruit                         2.000000   1.000  1.000  11  
10001810 10   Grapefruit, juice                  2.000000   0.060  1.000  11  
10001970 10   Kumquat                            2.000000   1.000  1.000      
10001990 10   Lemon                              2.000000   1.000  1.000      
10002000 10   Lemon, juice                       2.000000   0.060  1.000      
10002001 10   Lemon, juice-babyfood              2.000000   0.060  1.000      
10002010 10   Lemon, peel                        2.000000   2.600  1.000      
10002060 10   Lime                               2.000000   1.000  1.000      
10002070 10   Lime, juice                        2.000000   0.060  1.000      
10002071 10   Lime, juice-babyfood               2.000000   0.060  1.000      
10002400 10   Orange                             2.000000   1.000  1.000   8  
10002410 10   Orange, juice                      2.000000   0.060  1.000   8  
10002411 10   Orange, juice-babyfood             2.000000   0.060  1.000   8  
10002420 10   Orange, peel                       2.000000   2.600  0.350      
10003070 10   Pummelo                            2.000000   1.000  1.000      
10003690 10   Tangerine                          2.000000   1.000  1.000  16  
10003700 10   Tangerine, juice                   2.000000   0.060  1.000  16  
11000070 11   Apple, fruit with peel             5.000000   1.000  1.000   1  
11000080 11   Apple, peeled fruit                5.000000   1.000  1.000   1  
11000081 11   Apple, peeled fruit-babyfood       5.000000   1.000  1.000   1  
11000090 11   Apple, dried                       0.770000   8.000  0.150      
11000091 11   Apple, dried-babyfood              0.770000   8.000  0.150      
11000100 11   Apple, juice                       5.000000   1.000  1.000  25  
11000101 11   Apple, juice-babyfood              5.000000   1.000  1.000  25  
11000110 11   Apple, sauce                       5.000000   1.000  1.000   1  
11000111 11   Apple, sauce-babyfood              5.000000   1.000  1.000   1  
11001290 11   Crabapple                          5.000000   1.000  1.000      
11002100 11   Loquat                             5.000000   1.000  1.000      
11002660 11   Pear                               5.000000   1.000  1.000   2  
11002661 11   Pear-babyfood                      5.000000   1.000  1.000   2  
11002670 11   Pear, dried                        0.880000   6.250  0.100      
11002680 11   Pear, juice                        5.000000   1.000  1.000   2  
11002681 11   Pear, juice-babyfood               5.000000   1.000  1.000   2  
11003100 11   Quince                             5.000000   1.000  1.000      
12000120 12   Apricot                            1.400000   1.000  1.000  13  
12000121 12   Apricot-babyfood                   1.400000   1.000  1.000  13  
12000130 12   Apricot, dried                     0.740000   6.000  0.025      
12000140 12   Apricot, juice                     1.400000   1.000  1.000  13  
12000141 12   Apricot, juice-babyfood            1.400000   1.000  1.000  13  
12000900 12   Cherry                             5.000000   1.000  1.000   4  
12000901 12   Cherry-babyfood                    5.000000   1.000  1.000   4  
12000910 12   Cherry, juice                      5.000000   1.500  1.000   4  
12000911 12   Cherry, juice-babyfood             5.000000   1.500  1.000   4  
12002300 12   Nectarine                          1.400000   1.000  1.000   5  
12002600 12   Peach                              1.400000   1.000  1.000   5  
12002601 12   Peach-babyfood                     1.400000   1.000  1.000   5  
12002610 12   Peach, dried                       0.740000   7.000  0.025      
12002611 12   Peach, dried-babyfood              0.740000   7.000  0.025      
12002620 12   Peach, juice                       1.400000   1.000  1.000   5  
12002621 12   Peach, juice-babyfood              1.400000   1.000  1.000   5  
12002850 12   Plum                               1.400000   1.000  1.000   6  
12002851 12   Plum-babyfood                      1.400000   1.000  1.000   6  
12002860 12   Plum, prune, fresh                 1.400000   1.000  1.000   6  
12002861 12   Plum, prune, fresh-babyfood        1.400000   1.000  1.000   6  
12002870 12   Plum, prune, dried                 1.400000   2.600  1.000   6  
12002871 12   Plum, prune, dried-babyfood        1.400000   2.600  1.000   6  
12002880 12   Plum, prune, juice                 1.400000   1.400  1.000   6  
12002881 12   Plum, prune, juice-babyfood        1.400000   1.400  1.000   6  
13010550 13A  Blackberry                        12.000000   1.000  1.000  12  
13010560 13A  Blackberry, juice                 12.000000   1.000  1.000  12  
13010561 13A  Blackberry, juice-babyfood        12.000000   1.000  1.000  12  
13010580 13A  Boysenberry                       12.000000   1.000  1.000      
13011420 13A  Dewberry                          12.000000   1.000  1.000      
13012080 13A  Loganberry                        12.000000   1.000  1.000      
13013200 13A  Raspberry                         12.000000   1.000  1.000  12  
13013201 13A  Raspberry-babyfood                12.000000   1.000  1.000  12  
13013210 13A  Raspberry, juice                  12.000000   1.000  1.000  12  
13013211 13A  Raspberry, juice-babyfood         12.000000   1.000  1.000  12  
13020570 13B  Blueberry                          3.000000   1.000  1.000   9  
13020571 13B  Blueberry-babyfood                 3.000000   1.000  1.000   9  
13021360 13B  Currant                            3.000000   1.000  1.000      
13021370 13B  Currant, dried                     3.000000   1.000  1.000      
13021490 13B  Elderberry                         3.000000   1.000  1.000      
13021740 13B  Gooseberry                         3.000000   1.000  1.000      
13021910 13B  Huckleberry                        3.000000   1.000  1.000   9  
14000030 14   Almond                             0.100000   1.000  1.000      
14000031 14   Almond-babyfood                    0.100000   1.000  1.000      
14000040 14   Almond, oil                        0.100000   1.000  1.000      
14000041 14   Almond, oil-babyfood               0.100000   1.000  1.000      
14000590 14   Brazil nut                         0.100000   1.000  1.000      
14000680 14   Butternut                          0.100000   1.000  1.000      
14000810 14   Cashew                             0.100000   1.000  1.000      
14000920 14   Chestnut                           0.100000   1.000  1.000      
14001550 14   Filbert                            0.100000   1.000  1.000      
14001560 14   Filbert, oil                       0.100000   1.000  1.000      
14001850 14   Hickory nut                        0.100000   1.000  1.000      
14002130 14   Macadamia nut                      0.100000   1.000  1.000      
14002690 14   Pecan                              0.100000   1.000  1.000      
14002820 14   Pistachio                          0.100000   1.000  1.000      
14003910 14   Walnut                             0.100000   1.000  1.000      
21000440 M    Beef, meat                         0.010000   1.000  1.000      
21000441 M    Beef, meat-babyfood                0.010000   1.000  1.000      
21000450 M    Beef, meat, dried                  0.010000   1.920  1.000      
21000460 M    Beef, meat byproducts              0.010000   1.000  1.000      
21000461 M    Beef, meat byproducts-babyfood     0.010000   1.000  1.000      
21000470 M    Beef, fat                          0.050000   1.000  1.000      
21000471 M    Beef,fat-babyfood                  0.050000   1.000  1.000      
21000480 M    Beef, kidney                       0.010000   1.000  1.000      
21000490 M    Beef, liver                        0.010000   1.000  1.000      
21000491 M    Beef, liver-babyfood               0.010000   1.000  1.000      
23001690 M    Goat, meat                         0.010000   1.000  1.000      
23001700 M    Goat, meat byproducts              0.010000   1.000  1.000      
23001710 M    Goat, fat                          0.050000   1.000  1.000      
23001720 M    Goat, kidney                       0.010000   1.000  1.000      
23001730 M    Goat, liver                        0.010000   1.000  1.000      
24001890 M    Horse, meat                        0.010000   1.000  1.000      
26003390 M    Sheep, meat                        0.010000   1.000  1.000      
26003391 M    Sheep, meat-babyfood               0.010000   1.000  1.000      
26003400 M    Sheep, meat byproducts             0.010000   1.000  1.000      
26003410 M    Sheep, fat                         0.050000   1.000  1.000      
26003411 M    Sheep, fat-babyfood                0.050000   1.000  1.000      
26003420 M    Sheep, kidney                      0.010000   1.000  1.000      
26003430 M    Sheep, liver                       0.010000   1.000  1.000      
27002220 D    Milk, fat                          0.050000   1.000  1.000      
27002221 D    Milk, fat - baby food/infant for   0.050000   1.000  1.000      
40000930 P    Chicken, meat                      0.050000   1.000  1.000      
40000931 P    Chicken, meat-babyfood             0.050000   1.000  1.000      
40000940 P    Chicken, liver                     0.050000   1.000  1.000      
40000950 P    Chicken, meat byproducts           0.050000   1.000  1.000      
40000951 P    Chicken, meat byproducts-babyfoo   0.050000   1.000  1.000      
40000960 P    Chicken, fat                       0.050000   1.000  1.000      
40000961 P    Chicken, fat-babyfood              0.050000   1.000  1.000      
40000970 P    Chicken, skin                      0.050000   1.000  1.000      
40000971 P    Chicken, skin-babyfood             0.050000   1.000  1.000      
50003820 P    Turkey, meat                       0.050000   1.000  1.000      
50003821 P    Turkey, meat-babyfood              0.050000   1.000  1.000      
50003830 P    Turkey, liver                      0.050000   1.000  1.000      
50003831 P    Turkey, liver-babyfood             0.050000   1.000  1.000      
50003840 P    Turkey, meat byproducts            0.050000   1.000  1.000      
50003841 P    Turkey, meat byproducts-babyfood   0.050000   1.000  1.000      
50003850 P    Turkey, fat                        0.050000   1.000  1.000      
50003851 P    Turkey, fat-babyfood               0.050000   1.000  1.000      
50003860 P    Turkey, skin                       0.050000   1.000  1.000      
50003861 P    Turkey, skin-babyfood              0.050000   1.000  1.000      
60003010 P    Poultry, other, meat               0.050000   1.000  1.000      
60003020 P    Poultry, other, liver              0.050000   1.000  1.000      
60003030 P    Poultry, other, meat byproducts    0.050000   1.000  1.000      
60003040 P    Poultry, other, fat                0.050000   1.000  1.000      
60003050 P    Poultry, other, skin               0.050000   1.000  1.000      
70001450 P    Egg, whole                         0.050000   1.000  1.000      
70001451 P    Egg, whole-babyfood                0.050000   1.000  1.000      
70001460 P    Egg, white                         0.050000   1.000  1.000      
70001461 P    Egg, white (solids)-babyfood       0.050000   1.000  1.000      
70001470 P    Egg, yolk                          0.050000   1.000  1.000      
70001471 P    Egg, yolk-babyfood                 0.050000   1.000  1.000      
86010000 O    Water, direct, all sources         0.010300   1.000  1.000      
86020000 O    Water, indirect, all sources       0.010300   1.000  1.000      
95000010 O    Acerola                            1.500000   1.000  1.000      
95000200 O    Avocado                            1.000000   1.000  1.000      
95000740 O    Canistel                           1.000000   1.000  1.000      
95000890 O    Cherimoya                          1.000000   1.000  1.000      
95001280 O    Cottonseed, oil                    3.000000   1.000  0.025      
95001281 O    Cottonseed, oil-babyfood           3.000000   1.000  0.025      
95001750 O    Grape                              5.000000   1.000  1.000   3  
95001760 O    Grape, juice                       5.000000   1.000  1.000  26  
95001761 O    Grape, juice-babyfood              5.000000   1.000  1.000  26  
95001770 O    Grape, leaves                      5.000000   1.000  0.100      
95001780 O    Grape, raisin                      5.000000   1.540  1.000   3  
95001790 O    Grape, wine and sherry             5.000000   0.003  1.000   3  
95001830 O    Guava                              1.500000   1.000  1.000  27      
95001831 O    Guava-babyfood                     1.500000   1.000  1.000  27    
95001920 O    Jaboticaba                         1.500000   1.000  1.000      
95002090 O    Longan                             3.000000   1.000  1.000      
95002110 O    Lychee                             3.000000   1.000  1.000      
95002120 O    Lychee, dried                      3.000000   1.000  1.000      
95002150 O    Mango                              1.000000   1.000  1.000  15  
95002151 O    Mango-babyfood                     1.000000   1.000  1.000  15  
95002160 O    Mango, dried                       1.000000   1.000  1.000      
95002170 O    Mango, juice                       1.000000   1.000  1.000  15  
95002171 O    Mango, juice-babyfood              1.000000   1.000  1.000  15  
95002350 O    Olive                              5.000000   1.000  1.000  18  
95002360 O    Olive, oil                         5.000000   1.000  1.000      
95002450 O    Papaya                             1.000000   1.000  1.000  15  
95002451 O    Papaya-babyfood                    1.000000   1.000  1.000  15  
95002460 O    Papaya, dried                      1.000000   1.800  1.000      
95002470 O    Papaya, juice                      1.000000   1.500  1.000  15  
95002520 O    Passionfruit                       1.500000   1.000  1.000  27      
95002521 O    Passionfruit-babyfood              1.500000   1.000  1.000  27    
95002530 O    Passionfruit, juice                1.500000   1.000  1.000  27    
95002531 O    Passionfruit, juice-babyfood       1.500000   1.000  1.000  27    
95002630 O    Peanut                             0.010000   1.000  1.000      
95002640 O    Peanut, butter                     0.010000   1.890  1.000      
95002650 O    Peanut, oil                        0.010000   4.000  1.000      
95003330 O    Sapote, Mamey                      1.000000   1.000  1.000      
95003460 O    Soursop                            1.000000   1.000  1.000      
95003510 O    Spanish lime                       3.000000   1.000  1.000      
95003580 O    Starfruit                          1.500000   1.000  1.000      
95003590 O    Strawberry                         2.000000   1.000  1.000  10  
95003591 O    Strawberry-babyfood                2.000000   1.000  1.000  10  
95003600 O    Strawberry, juice                  2.000000   1.000  1.000  10  
95003601 O    Strawberry, juice-babyfood         2.000000   1.000  1.000  10  
95003610 O    Sugar apple                        1.000000   1.000  1.000      
95003720 O    Tea, dried                         2.000000   1.000  1.000      
95003730 O    Tea, instant                       2.000000   1.000  1.000      

Attachment 2:  Results of Acute Dietary Exposure Assessment

DEEM-FCID Version 2.03 (1994-98 data)
Residue file: FenpropAcutePDP.R98
Residue file dated: 06-10-2012/10:40:51/8

Analysis Dates: 06-10-2012/10:53:47 (Adults)
                          06-10-2012/10:48:49 (Infants and Children)    

Adjustment factor #2 used.
Daily totals for food and foodform consumption used.
MC iterations = 1000      MC list in residue file     MC seed = 10

aPAD for Youth and Adults (>6 years of Age):  0.05 mg/kg/day
aPAD for Infants and Children (6 years of age and under):  0.017 mg/kg/day

===============================================================================

Summary calculations (per capita):

      95th Percentile             99th Percentile             99.9th Percentile
 Exposure  % aRfD     MOE    Exposure  % aRfD     MOE    Exposure  % aRfD     MOE  
---------- ------- -------- ---------- ------- -------- ---------- ------- --------
U.S. Population:
  0.001758    3.52    2844    0.003745    7.49    1335    0.009489   18.98     526  

All infants:
  0.002466   14.51    2027    0.004525   26.62    1105    0.011457   67.40     436  
Children 1-2 yrs:
  0.002652   15.60    1885    0.006247   36.75     800    0.015343   90.26     325  
Children 3-5 yrs:
  0.002547   14.98    1963    0.005918   34.81     844    0.016488   96.99     303  

Children 6-12 yrs:
  0.001727    3.45    2894    0.004466    8.93    1119    0.013489   26.98     370  
Youth 13-19 yrs:
  0.001388    2.78    3603    0.002998    6.00    1667    0.009290   18.58     538  
Adults 20-49 yrs:
  0.001723    3.45    2901    0.003557    7.11    1405    0.007920   15.84     631  
Adults 50+ yrs:
  0.001578    3.16    3167    0.003327    6.65    1503    0.008093   16.19     617  
Females 13-49 yrs:
  0.001648    3.30    3033    0.003340    6.68    1496    0.008476   16.95     589  

 Attachment 3.  Residue Inputs for Individual Commodities

                                   Commodity
                                Blending Class.
                                  Data Source
                                    RDF No.
                                     Max.
                                      %CT
Broccoli (and baby food)
                                     NB/PB
                                      PDP
                            (Broccoli: 2007, 2008)
                                       7
                                      2.5
Broccoli, Chinese
                                      NB
                                   Tolerance
                                       -
                                      100
Brussels Sprouts
                                      PB
                                 FT (Cabbage)
                                      24
                                      10
Cabbage
                                     NB/PB
                                 FT (Cabbage)
                                      14
                                      2.5
Cabbage, Chinese napa
                                     NB/PB
                                 FT (Cabbage)
                                      22
                                      100
Cabbage, Chinese mustard
                                     NB/PB
                                      PDP
                            (Broccoli: 2007, 2008)
                                      23
                                      100
Cauliflower
                                     NB/PB
                                      PDP
                            (Broccoli: 2007, 2008)
                                       7
                                      2.5
Kohlrabi
                                      NB
                                   Tolerance
                                       -
                                      100
Pea, succulent
                                      PB
                                   Tolerance
                                       -
                                      100
Eggplant
                                     NB/PB
                                   Tolerance
                                       -
                                      100
Okra
                                     NB/PB
                                   Tolerance
                                       -
                                      100
Pepper, Bell (and baby food)
                                     NB/PB
                                   Tolerance
                                       -
                                      100
Pepper, Bell - Dried (and baby food)
                                       B
                                   Tolerance
                                       -
                                      100
Pepper, Nonbell (and baby food)
                                     NB/PB
                                   Tolerance
                                       -
                                      100
Pepper, Nonbell - Dried
                                       B
                                   Tolerance
                                       -
                                      100
Tomatillo
                                     NB/PB
                                   Tolerance
                                       -
                                      100
Tomato (and baby food)
                                     NB/PB
                                  FT (Tomato)
                                      19
                                      10
Tomato paste
                                       B
                                   Tolerance
                                       -
                                      10
Tomato puree
                                       B
                                   Tolerance
                                       -
                                      10
Tomato  -  dried
                                       B
                                   Tolerance
                                       -
                                      10
Tomato juice
                                      PB
                                  FT (Tomato)
                                      19
                                      10
Cantaloupe
                                     NB/PB
                                   Tolerance
                                       -
                                      100
Casaba
                                      NB
                                   Tolerance
                                       -
                                      100
Honeydew melon
                                     NB/PB
                                   Tolerance
                                       -
                                      100
Watermelon and Watermelon juice
                                      NB
                                      PDP
                              (Watermelon: 2010)
                                      17
                                      2.5
Balsam Pear
                                      NB
                                   Tolerance
                                       -
                                      100
Chayote, fruit
                                      NB
                                   Tolerance
                                       -
                                      100
Chinese Waxgourd
                                      NB
                                   Tolerance
                                       -
                                      100
Cucumber
                                     NB/PB
                                 FT (Cucumber)
                                      20
                                      2.5
Pumpkin
                                     NB/PB
                                   Tolerance
                                       -
                                      100
Pumpkin seed
                                       B
                                   Tolerance
                                       -
                                      100
Squash, summer (and baby food)
                                     NB/PB
                           PDP (Squash: 2007, 2008)
                                      21
                                      2.5
Squash, winter (and baby food)
                                     NB/PB
                           PDP (Squash: 2007, 2008)
                                      21
                                      2.5
Citrus citron
                                      NB
                                   Tolerance
                                       -
                                      100
Citrus hybrids
                                      NB
                                   Tolerance
                                       -
                                      100
Citrus oil
                                       B
                                   Tolerance
                                       -
                                      100
Grapefruit and grapefruit juice
                                     NB/PB
                                FT (Grapefruit)
                                      11
                                      35
Kumquat
                                      NB
                                   Tolerance
                                       -
                                      100
Lemon (fruit, juice, juice baby food, and peel)
                                     NB/PB
                                   Tolerance
                                       -
                                      100
Lime (fruit and juice)
                                      PB
                                   Tolerance
                                       -
                                      100
Orange (fruit, juice, and juice baby food)
                                     NB/PB
                           PDP (Orange: 2009, 2010)
                                       8
                                      35
Orange peel
                                      PB
                                   Tolerance
                                       -
                                      35
Pummelo
                                      NB
                                   Tolerance
                                       -
                                      100
Tangerine (fruit and juice)
                                     NB/PB
                           PDP (Orange: 2009, 2010)
                                      16
                                      15
Apple (fruit and fruit baby food)
                                     NB/PB
                            PDP (Apple: 2009, 2010)
                                       1
                                      15
Apple  -  dried (and baby food)
                                       B
                           Avg FT (Apple, 0.77 ppm)
                                       -
                                      15
Apple juice (and baby food)
                                      PB
                                      PDP
                           (Apple Juice: 2007, 2008)
                                      25
                                      15
Apple sauce (and baby food)
                                      PB
                            PDP (Apple: 2009, 2010)
                                       1
                                      15
Crabapple
                                      NB
                                   Tolerance
                                       -
                                      100
Loquat
                                      NB
                                   Tolerance
                                       -
                                      100
Pear (and baby food)
                                     NB/PB
                            PDP (Pear: 2008, 2009)
                                       2
                                      10
Pear  -  dried
                                       B
                                 Avg FT (Pear)
                                       -
                                      10
Pear juice (and baby food)
                                      PB
                            PDP (Pear: 2008, 2009)
                                       2
                                      10
Quince
                                      NB
                                   Tolerance
                                       -
                                      100
Apricot (and baby food)
                                     NB/PB
                                  FT (Peach)
                                      13
                                      2.5
Apricot - dried
                                       B
                           Avg FT (Peach, 0.74 ppm)
                                       -
                                      2.5
Apricot juice (and baby food)
                                      PB
                                  FT (Peach)
                                      13
                                      2.5
Cherry (and baby food)
                                      PB
                                  FT (Cherry)
                                       4
                                       5
Cherry juice (and baby food)
                                      PB
                                  FT (Cherry)
                                       4
                                       5
Nectarine
                                      NB
                                  FT (Peach)
                                       5
                                      2.5
Peach (and baby food)
                                     NB/PB
                                  FT (Peach)
                                       5
                                      2.5
Peach - dried (and baby food)
                                       B
                           Avg FT (Peach, 0.74 ppm)
                                       -
                                      2.5
Peach juice (and baby food)
                                      PB
                                  FT (Peach)
                                       5
                                      2.5
Plum (and baby food)
                                     NB/PB
                                   FT (Plum)
                                       6
                                      2.5
Plum, prune, fresh (and baby food)
                                     NB/PB
                                   FT (Plum)
                                       6
                                      2.5
Plum, prune  -  dried (and baby food)
                                      PB
                                   FT (Plum)
                                       6
                                      2.5
Plum, prune, juice (and baby food)
                                     NB/PB
                                   FT (Plum)
                                       6
                                      2.5
Blackberry
                                      PB
                             FT (Black/Raspberry)
                                      12
                                      100
Blackberry juice (and baby food)
                                      PB
                             FT (Black/Raspberry)
                                      12
                                      100
Boysenberry
                                      PB
                                   Tolerance
                                       -
                                      100
Dewberry
                                      PB
                                   Tolerance
                                       -
                                      100
Loganberry
                                      PB
                                   Tolerance
                                       -
                                      100
Raspberry (and baby food)
                                      PB
                             FT (Black/Raspberry)
                                      12
                                      100
Raspberry juice (and baby food)
                                      PB
                             FT (Black/Raspberry)
                                      12
                                      100
Blueberry (and baby food)
                                      PB
                                      PDP
                            (Blueberry: 2007, 2008)
                                       9
                                      2.5
Currant and Currant  -  dried
                                      PB
                                   Tolerance
                                       -
                                      100
Elderberry
                                      PB
                                   Tolerance
                                       -
                                      100
Gooseberry
                                      PB
                                   Tolerance
                                       -
                                      100
Huckleberry
                                      PB
                                      PDP
                            (Blueberry: 2007, 2008)
                                       9
                                      100
Tree nuts (almond (and baby food), brazil nut, cashew, chestnut, filbert, hickory nut, macadamia nut, pecan, pistachio, walnut)
                                      PB
                                   Tolerance
                                       -
                                      100
Tree nuts (butter nut)
                                      NB
                                   Tolerance
                                       -
                                      100
Almond oil (and baby food)
                                       B
                                   Tolerance
                                       -
                                      100
Filbert oil 
                                       B
                                   Tolerance
                                       -
                                      100
                                       
Beef (meat, meat-babyfood, meat byproducts, meat byproducts-babyfood, kidney, liver, liver-babyfood)
                                       -
                       Recommended Reassessed Tolerance
                                  (0.01 ppm)
                                       -
                                      100
Beef, meat  -  dried
                                       -
                            Recommended Tol. (0.01)
                                       -
                                      100
Beef fat (and baby food)
                                       -
                            Recommended Tol. (0.05)
                                       -
                                      100
Goat (meat, meat byproducts, kidney, liver)
                                       -
                            Recommended Tol. (0.01)
                                       -
                                      100
Goat fat
                                       -
                            Recommended Tol. (0.05)
                                       -
                                      100
Horse meat
                                       -
                            Recommended Tol. (0.01)
                                       -
                                      100
Sheep (meat, meat babyfood, meat byproducts, kidney, liver)
                                       -
                  Recommended Reassessed Tolerance (0.01 ppm)
                                       -
                                      100
Sheep fat (and baby food)
                                       -
                            Recommended Tol. (0.05)
                                       -
                                      100
Milk fat (and baby food)
                                       -
                            Recommended Tol. (0.05)
                                       -
                                      100
Chicken, Turkey, Poultry, other (all food forms)
                                       -
                                   Tolerance
                                       -
                                      100
Egg - whole, white, yolk (and baby food)
                                       -
                                   Tolerance
                                       -
                                      100
Water, direct and indirect, all sources
                                       -
                                EFED Water Memo
                                       -
                                       -
Acerola
                                      NB
                                Tol. (proposed)
                                       -
                                      100
Avocado
                                      NB
                                   Tolerance
                                       -
                                      100
Canistel
                                      NB
                                   Tolerance
                                       -
                                      100
Cherimoya
                                      NB
                                   Tolerance
                                       -
                                      100
Cottonseed oil (and baby food)
                                       B
                                   Tolerance
                                       -
                                      2.5
Grape
                                      PB
                            PDP (Grape: 2009, 2010)
                                       3
                                      10
Grape Juice (and baby food)
                                      PB
                            PDP (Grape Juice: 2008)
                                      26
                                      10
Grape Leaves
                                      PB
                                   Tolerance
                                       -
                                      10
Grape, raisin
Grape, wine and sherry
                                      PB
                            PDP (Grape: 2009, 2010)
                                       3
                                      10
Guava (and baby food)
                                     NB/PB
                                  FT (Guava)
                                      27
                                      100
Jaboticaba
                                      NB
                                Tol. (proposed)
                                       -
                                      100
Longan
                                      NB
                                Tol. (proposed)
                                       -
                                      100
Lychee
                                      NB
                                Tol. (proposed)
                                       -
                                      100
Lychee - dried
                                       B
                                Tol. (proposed)
                                       -
                                      100
Mango (and baby food)
                                     NB/PB
                                 FT (Avocado)
                                      15
                                      100
Mango, dried
                                      NB
                                   Tolerance
                                       -
                                      100
Mango, juice (and baby food)
                                      PB
                                   Tolerance
                                      15
                                      100
Olive
                                      PB
                                  FT (Olive)
                                      18
                                      100
Olive Oil
                                       B
                                   Tolerance
                                       -
                                      100
Papaya (and baby food)
                                     NB/PB
                                 FT (Avocado)
                                      15
                                      100
Papaya, dried
                                       B
                                   Tolerance
                                       -
                                      100
Papaya, juice
                                      PB
                                 FT (Avocado)
                                      15
                                      100
Passionfruit
                                      NB
                                  FT (Guava)
                                      27
                                      100
Passionfruit, juice (and baby food)
                                      PB
                                  FT (Guava)
                                      27
                                      100
Peanut, Peanut Butter, and Peanut Oil
                                       B
                                   Tolerance
                                       -
                                      100
Sapote, mamey
                                      NB
                                   Tolerance
                                       -
                                      100
Soursop
                                      NB
                                Tol. (proposed)
                                       -
                                      100
Spanish Lime
                                      NB
                                Tol. (proposed)
                                       -
                                      100
Starfruit
                                      NB
                                Tol. (proposed)
                                       -
                                      100
Strawberry (and baby food)
Strawberry Juice (and baby food)
                                      PB
                                      PDP
                           (Strawberry: 2008, 2009)
                                      10
                                      50
Sugar Apple
                                      NB
                                Tol. (proposed)
                                       -
                                      100
Tea, dried and instant
                                       B
                                Tol. (proposed)
                                       -
                                      100

 Attachment 4:  Residue Distribution Files
 
 RDF #1
 PDP Data
 
 Apples  15%CT
 TotalZ = 1251
 TotalLOD = 176
 LODRES = 0.0079
 0.29
 0.19
 0.14
 0.11
 0.1
 0.1
 0.1
 0.098
 0.097
 0.097
 0.089
 0.088
 0.087
 0.084
 0.076
 0.069
 0.064
 0.062
 0.026
 0.026
 0.20
 0.19
 0.19
 0.17
 0.17
 0.16
 0.16
 0.15
 0.14
 0.068
 0.066
 0.063
 0.062
 0.06
 0.06
 0.056
 0.052
 0.026
 0.026
 0.026
 0.026
 0.026
 0.026
 0.015
 0.015
 RDF #2
 PDP Data
 
 Pears  PDP Data 10%CT
 TotalZ = 1336
 TotalLOD = 145
 LODRES = 0.0185
 0.61
 0.52
 0.47
 0.062
 
 
 
 
 
 
 RDF #4
 Field Trial Data
 
 Cherry FT Data  5%CT
 TotalNZ = 12
 TotalZ = 228
 
 1.83
 1.97
 2.02
 1.60
 1.44
 1.43
 3.18
 3.33
 1.59
 1.43
 3.53
 3.23
 
 
 
 
 
 
 RDF #6
 Field Trial Data
 
 Plum FT Data 2.5%CT
 TotalNZ = 11
 TotalZ = 429
 
 0.51
 0.58
 0.23
 0.23
 0.29
 0.21
 0.37
 0.27
 0.24
 0.20
 0.18
 RDF #3
 PDP Data
 
 Grape PDP Data 10%CT
 TotalZ = 1340
 TotalLOD = 51
 LODRES = 0.007885
 RDF #5
 Field Trial Data
 
 Peach Field Trial Data 2.5%CT
 TotalNZ = 20
 TotalZ = 780
 
 0.66
 0.66
 0.76
 0.63
 0.56
 0.73
 0.91
 1.11
 1.05
 1.01
 0.69
 0.72
 0.79
 0.67
 0.61
 0.54
 0.39
 0.49
 1.00
 0.84
 
 
 
 
 
 
 
 RDF #7
 PDP Data
 
 Broccoli  2.5%CT
 TotalZ = 1258
 TotalLOD = 32
 LODRES = 0.0078
 
 
 
 
 
 
 RDF #8
 PDP Data
 
 Orange  PDP Data 35%CT
 TotalZ = 913
 TotalLOD = 491
 LODRES = 0.007051
 RDF #9
 PDP Data
 
 Blueberries PDP Data  2.5%CT
 TotalZ = 1401
 TotalLOD = 11
 LODRES = 0.007573
 1.3
 1.2
 0.87
 0.59
 0.43
 0.32
 0.27
 0.20
 0.19
 0.14
 0.14
 0.092
 0.077
 0.074
 0.065
 0.060
 0.026
 0.026
 0.026
 0.026
 0.38
 0.37
 0.29
 0.24
 0.17
 
 
 0.21
 0.20
 0.19
 0.17
 0.16
 0.15
 0.14
 0.13
 0.12
 0.12
 0.12
 0.11
 0.11
 0.11
 0.11
 0.096
 0.094
 0.092
 0.086
 0.083
 0.066
 0.066
 0.065
 0.065
 0.065
 0.060
 0.060
 0.059
 0.057
 0.057
 0.056
 0.053
 0.053
 0.053
 0.052
 0.050
 0.048
 0.047
 0.046
 0.045
 0.043
 0.040
 0.038
 0.035
 0.034
 0.031
 0.031
 0.029
 0.028
 0.028
 0.024
 0.021
 0.020
 0.020
 0.020
 
 0.015
 0.015
 0.015
 0.015
 0.015
 0.015
 0.015
 0.57
 0.16
 0.16
 0.14
 0.12
 0.12
 0.11
 0.098
 0.09
 0.089
 0.081
 0.075
 0.07
 0.055
 0.053
 0.053
 0.05
 0.043
 0.043
 0.04
 0.038
 0.036
 0.036
 0.033
 0.033
 0.031
 0.031
 0.028
 0.015
 0.015
 0.015
 0.015
 0.015
 0.015
 0.015
 0.015
 
 
  
RDF #10
PDP Data

Strawberries  50%CT
TotalZ = 742
TotalLOD = 595
LODRES = 0.006634
RDF #11
Field Trial Data

Grapefruit FT Data 35%CT
TotalNZ = 14
TotalZ = 26

0.57
0.40
0.38
0.36
0.36
0.35
0.32
0.27
0.23
0.18
0.18
0.16
0.13
0.11

RDF #12
Field Trial Data

Caneberry FT Data 100%CT
TotalNZ = 14
TotalZ = 0

7.1
6.1
5.5
4.7
4.1
3.3
2.3
1.9
1.8
1.8
1.7
1.4
1.2
1.0
RDF #13
Field Trial Data

Apricot (Peach FT Data) 2.5%CT
TotalNZ = 20
TotalZ = 780

0.66
0.66
0.76
0.63
0.56
0.73
0.91
1.11
1.05
1.01
0.69
0.72
0.79
0.67
0.61
0.54
0.39
0.49
1.00
0.84

RDF #14
Field Trial Data

Cabbage FT Data 2.5%CT
TotalNZ = 12
TotalZ = 468

2.8
2.7
1.3
1.2
0.67
0.45
0.41
0.40
0.30
0.30
0.24
0.20
RDF #15
Field Trial Data

Papaya (Avocado FT Data)  100%CT
TotalNZ = 12
TotalZ = 0

0.58
0.52
0.51
0.45
0.42
0.42
0.40
0.38
0.32
0.31
0.20
0.14

RDF #16
PDP Data

Tangerines (Orange PDP Data) 15%CT
TotalZ = 1193
TotalLOD = 211
LODRES = 0.007051

RDF #17
PDP Data

Watermelon PDP Data  2.5%CT
TotalZ = 362
TotalLOD = 9
LODRES = 0.0045
RDF #18
Field Trial Data

Olive FT Data 100%CT
TotalNZ = 6
TotalZ = 0

3.7
3.4
2.3
2.1
2.0
1.8

RDF #19
Field Trial Data

Tomato FT Data 10%CT
TotalNZ = 32
TotalZ = 288

0.16
0.18
0.10
0.09
0.07
0.05
0.08
0.08
0.21
0.29
0.23
0.06
0.20
0.03
0.24
0.18
0.22
0.32
0.29
0.30
0.46
0.64
0.04
0.06
0.10
0.12
0.18
0.20
0.07
0.08
0.15
0.21
1.3
0.61
0.42
0.41
0.41
0.33
0.32
0.29
0.28
0.27
0.26
0.26
0.24
0.21
0.21
0.19
0.18
0.18
0.17
0.17
0.16
0.14
0.14
0.14
0.13
0.13
0.13
0.13
0.12
0.12
0.12
0.098
0.097
0.096
0.094
0.092
0.088
0.086
0.084
0.082
0.081
0.075
0.075
0.074
0.071
0.070
0.065
0.063
0.061
0.060
0.055
0.054
0.054
0.053

0.044
0.043
0.042
0.040
0.038
0.036
0.032
0.032
0.032
0.03
0.028
0.028
0.028
0.026
0.024
0.023
0.022
0.02
0.016
0.015
0.015
0.015
0.015
0.015
0.014
0.014
0.011
0.011
0.01
0.01
1.7
1.2
1.1
0.76
0.73
0.73
0.61
0.57
0.47
0.37
0.37
0.35
0.34
0.34
0.31
0.27
0.23
0.22
0.22
0.21
0.20
0.20
0.20
0.18

0.17
0.17
0.16
0.16
0.15
0.15
0.14
0.14
0.14
0.11
0.11
0.10
0.092
0.091
0.090
0.089
0.083
0.074
0.072
0.062
0.062
0.061
0.056
0.053
0.044
0.042
0.042
0.040
0.039
0.036
0.036
0.032
0.030
0.028
0.021
0.020
0.015
0.015
0.015
0.015

RDF #20
Field Trial Data

Cucumber FT Data 2.5%CT
TotalNZ = 20
TotalZ = 780

0.047
0.055
0.036
0.042
0.033
0.034
0.01
0.01
0.01
0.011
0.010
0.01
0.01
0.01
0.01
0.01
0.027
0.020
0.01
0.01

RDF #21
PDP Data

Squash PDP Data 2.5%CT
TotalZ = 1264
TotalLOD = 32
LODRES = 0.01984

RDF #22
Field Trial Data

Chinese Napa Cabbage (Cabbage FT Data) 100%CT
TotalNZ = 12
TotalZ = 0

2.8
2.7
1.3
1.2
0.67
0.45
0.41
0.40
0.30
0.30
0.24
0.20

RDF #23
PDP Data

Chinese Mustard Cabbage (Broccoli PDP) 100%CT
TotalZ = 0
TotalLOD = 32
LODRES = 0.0078
RDF #24
Field Trial Data

Brussels Sprouts (Cabbage FT Data) 10%CT
TotalNZ = 12
TotalZ = 108

2.8
2.7
1.3
1.2
0.67
0.45
0.41
0.40
0.30
0.30
0.24
0.20
RDF #25
PDP Data

Apple Juice PDP Data  15%CT
TotalZ = 629
TotalLOD = 111
LODRES = 0.01975
RDF #26
PDP Data

Grape Juice PDP Data  10%CT
TotalZ = 670
TotalLOD = 75
LODRES = 0.009507

RDF #27
Field Trial Data

Guava FT Data 100%CT
TotalNZ = 6
TotalZ = 0

1.09
0.949
0.608
0.577
0.566
0.484

                                 May 24, 2012
   Screening Level Estimates of Agricultural Uses of Fenpropathrin (127901)
                             Sorted Alphabetically
                       (Reporting Timeframe: 2003-2010)
                                       

                             Percent Crop Treated
                                     Crop
                                   Lbs. A.I.
                                    Average
                                    Maximum
1
Almonds
                                     4,000
                                    <2.5
                                    <2.5
2
Apples
                                    10,000
                                      10
                                      15
3
Apricots*
                                    <500
                                     <1
                                    <2.5
4
Avocados*
                                    <500
                                     <1
                                    <2.5
5
Blueberries
                                    <500
                                    <2.5
                                    <2.5
6
Broccoli*
                                    <500
                                     <1
                                    <2.5
7
Brussels Sprouts*
                                    <500
                                     <5
                                      10
8
Cabbage
                                    <500
                                     <1
                                    <2.5
9
Cantaloupes
                                    <500
                                    <2.5
                                       5
10
Cauliflower
                                    <500
                                     <1
                                    <2.5
11
Cherries
                                     1,000
                                    <2.5
                                       5
12
Cotton
                                     3,000
                                     <1
                                    <2.5
13
Cucumbers
                                    <500
                                     <1
                                    <2.5
14
Grapefruit
                                     4,000
                                      10
                                      35
15
Grapes
                                    10,000
                                       5
                                      10
16
Lemons
                                    <500
                                     <1
                                    <2.5
17
Nectarines*
                                    <500
                                    <2.5
                                    <2.5
18
Olives*
                                    <500
                                     <1
                                    <2.5
19
Oranges
                                    40,000
                                      15
                                      35
20
Peaches
                                    <500
                                     <1
                                    <2.5
21
Peanuts
                                     1,000
                                     <1
                                    <2.5
22
Pears
                                     1,000
                                       5
                                      10
23
Peppers
                                     2,000
                                       5
                                      10
24
Pistachios*
                                    <500
                                     <1
                                    <2.5
25
Plums/Prunes
                                     1,000
                                     <1
                                    <2.5
26
Pumpkin
                                    <500
                                     <1
                                    <2.5
27
Squash
                                    <500
                                     <1
                                    <2.5
28
Strawberries
                                     9,000
                                      30
                                      50
29
Tangelos
                                    <500
                                       5
                                      10
30
Tangerines
                                     1,000
                                      10
                                      15
31
Tomatoes
                                     4,000
                                       5
                                      10
32
Watermelon
                                    <500
                                     <1
                                    <2.5
All numbers rounded.
                                                                        <500
Less than 500 pounds of active ingredient
                                                                        <2.5
Less than 2.5 percent of crop treated
                                                                          <1
Less than 1 percent of crop treated
                                                                               

                                                                              *
Based on CA DPR data only (valid because 80% or more of U.S. acres grown are in California)
                                                                               

SLUA data sources include: USDA-NASS (United States Department of Agriculture's National Agricultural Statistics Service) 
Private Pesticide Market Research, California DPR (Department of Pesticide Regulation)
These results reflect amalgamated data developed by the Agency and are releasable to the public.