Document ID: EPA-HQ-OPP-2003-0072-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2003-02-13T05:00Z

1
January
31,
2003
MEMORANDUM
SUBJECT:
Atrazine:
Addendum
to
Revised
Human
Health
Risk
Assessment
for
the
Reregistration
Eligibility
Decision
(
RED)
dated
April
16,
2002.
PC
Code:
080803.
DP
Barcode:
D287740
FROM:
Catherine
Eiden,
Branch
Senior
Scientist
Reregistration
Branch
3
Health
Effects
Division
THROUGH:
Donna
Davis,
Branch
Chief
Reregistration
Branch
3
Health
Effects
Division
TO:
Kimberly
Lowe,
Chemical
Review
Manager
Special
Review
and
Reregistration
Division
Please
find
attached
an
addendum
to
HED's
April
16,
2002:
Revised
Human
Health
Risk
Assessment
for
the
Reregistration
Eligibility
Decision
(
RED).
This
addendum
includes
an
assessment
of
any
new
information
and
data
submitted
to
the
Agency
during
the
60­
day
public
comment
period
for
the
revised
human
health
risk
assessment.
Any
changes
in
the
outcome,
updates,
or
revisions
to
the
revised
human
health
risk
assessment
are
reflected
in
this
addendum.
The
revised
human
health
risk
assessment
(
4/
16/
02)
and
this
addendum
should
be
considered
together.
2
Background:

During
the
course
of
the
60­
day
public
comment
period
on
the
revised
atrazine
human
health
risk
assessment,
Syngenta
provided
additional
data,
information
or
studies
on
atrazine
for
HED's
consideration
and
review.
This
additional
information
has
affected
some
aspects
of
HED's
risk
assessment
for
atrazine.
Any
changes
to
the
risk
assessment
based
on
the
additional
information
are
reflected
in
this
addendum.
The
following
issues
and/
or
data
are
addressed
in
this
addendum:

°
HED's
conclusions
regarding
the
need
for
tolerances
for
hydroxy
atrazine
compounds.

°
Syngenta's
submitted
rotational
crop
study
data
for
garden
pea,
lima
bean,
and
potatoes.

HED's
conclusions
and
recommendations
regarding
rotational
crop
restrictions
based
on
the
results
of
this
study.

°
HED's
reassessment
of
the
DWLOC
value
to
be
used
in
the
risk
assessment
for
intermediate­
term
exposures.

°
The
results
of
an
analysis
of
Syngenta's
submitted
probabilistic
assessments
not
previously
submitted
for
an
11
additional
community
water
systems
(
CWS)
and
additional
monitoring
data
on
atrazine
in
finished
drinking
water
for
10
additional
states.

°
HED's
reassessed
risk
estimates
for
adults'
and
toddlers'
aggregate
short­
term
exposures
(
30
days
or
less)
to
atrazine
from
food,
drinking
water,
and
residential
uses
based
on
the
liquid
and
granular
turf
formulations.

°
Any
revisions
or
corrections
to
the
occupational/
residential
exposure
assessment.

Residue
Chemistry
Tolerance
Expression:

Section
9.0
­
Tolerance
Reassessment
Recommendations
This
section
should
read
as
follows:

The
HED
Metabolism
Assessment
Review
Committee
(
MARC)
met
on
January
29,
2003
to
reconsider
the
need
for
and
value
added
in
requiring
a
separate
tolerance
expression
for
hydroxy
atrazine
compounds.
The
MARC
concluded
the
tolerance
expression
should
include
the
parent
3
compound
atrazine
and
the
chlorinated
metabolites.

Tolerances
established
under
40
CFR
§
180.220(
a)(
1)
are
defined
for
residues
of
atrazine
per
se.
Tolerances
established
under
40
CFR
§
180.220(
a)(
2)
are
defined
for
atrazine
and
its
metabolites
2­
amino­
4­
chloro­
6­
ethylamino­
s­
triazine
(
G­
28279),
2­
amino­
4­
chloro­
6­
isopropylamino­
striazine
(
G­
30033),
and
2­
chloro­
4,6­
diamino­
s­
triazine
(
G­
28273).

In
accordance
with
the
Metabolism
Assessment
Review
Committee
(
MARC)
decisions
dated
11/
15/
00
and
01/
31/
03,
the
tolerance
expression
in
40
CFR
§
180.220(
a)(
1)
should
be
changed
to
reflect
the
combined
residues
of
atrazine
and
its
chlorinated
metabolites:
2­
amino­
4­
chloro­
6­
ethylamino­
s­
triazine
(
G­
28279),
2­
amino­
4­
chloro­
6­
isopropylamino­
s­
triazine
(
G­
30033),
and
2­
chloro­
4,6­
diamino­
s­
triazine
(
G­
28273)
which
serve
as
markers
for
enforcement
purposes
of
the
total
residues
of
atrazine,
that
is,
parent,
chlorinated
metabolites,
and
hydroxy
metabolites
(
2­
hydroxy­
4­
ethylamino­
6­
isopropylamino­
s­
triazine
(
G­
34048),
2­
amino­
4­
hydroxy­
6­
isopropylamino­
s­
triazine
(
GS­
17794),
2­
amino­
4­
hydroxy­
6­
ethylamino­
s­
triazine
(
GS­
17792),
and
2,4­
diamino­
6­
hydroxy­
s­
triazine
(
GS­
17791).
All
tolerances
based
on
atrazine
and
its
chlorinated
metabolites
should
be
placed
together
under
40
CFR
§
180.220
(
a)(
1).

In
accordance
with
MARC
memo
dated
01/
31/
03,
the
previous
requirement
for
a
separate
tolerance
expression
and
tolerances
for
the
hydroxy
metabolites
of
atrazine
has
been
rescinded.
The
MARC
concluded
that
because
a
validated
tolerance
enforcement
method
is
available
for
the
parent
and
chloroinated
metabolites,
the
parent
and
chlorinated
metabolites
are
detectable
by
multi­
residue
methods
(
860.1360),
and
the
data
collection
method
for
the
hydroxy
metabolites
has
not
been
validated
for
tolerance
enforcement
and
the
hydroxy
metabolites
have
not
been
tested
through
the
multi­
residue
protocols,
a
separate
tolerance
expression
for
the
hydroxy
compounds
would
be
ineffective
and
redundant.
In
addition,
residue
data
are
available
from
field
trials
and
metabolism
studies
for
dietary
risk
assessment
for
the
hydroxy
compounds,
and
MARC
and
HED
have
determined
that
finite
residues
of
the
hydroxy
compounds
are
not
anticipated
in
animal
commodities
and
classified
these
commodities
under
Category
180.6
(
a)
3.
However
the
MARC
recommends
that
the
hydroxy
metabolites
be
tested
through
the
multiresidue
methods,
OPPTS
Guideline
§
860.1360.

Detectable
residues
of
parent,
chlorinated
metabolites,
and
hydroxymetabolites
have
been
found
on
forages
and
other
feed
items.
Residues
of
the
parent
and
chloro­
metabolites
are
less
than
the
method
detection
limit
and
generally
non­
detectable
in/
on
corn
grain.
With
one
exception,
residues
of
the
hydroxy­
metabolites
in/
on
corn
grain
in
all
of
the
magnitude
of
residue
and
metabolism
studies
submitted
have
been
less
than
the
limit
of
quantitation
of
the
data
collection
method.
The
only
residue
exceeding
the
limit
of
quantiation
was
close
to
the
LOQ
at
an
4
exaggerated
application
rate.
In
addition,
although
the
metabolism
data
suggest
that
levels
of
the
hydroxy
metabolites
may
exceed
residues
of
the
parent
plus
chlorinated
metabolites
in
corn
grain,
residues
of
parent,
chlorinated
and
hydroxy
metabolites
are
all
likely
to
be
non­
detectable
at
the
current
application
rates.
Therefore,
the
MARC
concluded
that
the
parent
and
chlorinated
metabolites
will
be
an
adequate
marker
for
misuse
of
the
pesticide
and
should
be
included
in
the
tolerance
expression.

Section
9.5
­
Tolerances
to
be
Established
Under
40
CFR
§
180.220
(
a)(
2)

This
section
and
Table
20
should
be
deleted
from
the
human
health
risk
assessment.

Section
10
­
Data
needs/
Label
Requirements
Section
10.2
­
Residue
Chemistry
The
following
changes
should
be
made:

The
requirement
for
tolerances
on
the
hydroxy
metabolites
of
atrazine
should
be
deleted
from
this
section.
In
addition
to
the
data
requirements
already
listed
in
this
section,
a
data
requirement
should
be
added
for
submission
of
analytical
methods
AG­
484
and
596
for
testing
through
the
multi­
residue
methods,
OPPTS
Guideline
§
860.1360.

Rotational
Crop
Issues:

Syngenta
submitted
data
from
seven
rotational
crop
field
trials
conducted
in
Regions
1
(
NY;
3
trials),
4
(
MS;
2
trials),
and
5
(
IL;
2
trials).
A
90%
water
dispersible
granule
(
WDG)
formulation
of
atrazine
was
applied
to
the
primary
crop
(
field
corn)
using
two
treatment
regimes.
The
first
treatment
regime
consisted
of
a
preplant
(
or
at­
planting)
incorporated
application
at
2.0
lb
ai/
A
followed
by
an
over­
the­
top
postemergence
application
made
14­
20
days
later
at
0.5
lb
ai/
A,
for
a
total
application
rate
of
2.5
lb
ai/
A.
The
second
treatment
regime
consisted
of
a
single
preplant
(
or
at­
planting)
incorporated
application
made
at
1.0
lb
ai/
A.
Field
corn
was
harvested
at
normal
maturity
and
the
rotational
crops,
garden
pea,
lima
bean,
and
potato,
were
planted
­
9
and
­
10
months
following
the
last
treatment
to
the
primary
crop.
The
submitted
limited
rotational
field
study
is
acceptable.

Rotational
crop
samples
of
garden
pea,
lima
bean,
and
potato
were
harvested
at
normal
maturity.
Samples
were
analyzed
for
residues
of
atrazine
and
its
chloro
metabolites
G­
30033,
G­
28279,
and
G­
28273
using
GC/
NPD
Method
AG­
484
and
for
residues
of
atrazine's
hydroxy
metabolites
GS­
17792,
GS­
17794,
and
G­
34048
using
HPLC/
MS/
MS
Method
169­
99.
Residues
of
atrazine,
5
its
chloro
metabolites
(
G­
30033,
G­
28279,
and
G­
28273),
and
its
hydroxy
metabolites
(
GS­
17792,
GS­
17794,
and
G­
34048)
were
each
below
the
analytical
method's
limit
of
quantitation
(<
0.05
ppm)
in/
on
potato
tubers
and
shelled
succulent
peas
at
plantback
intervals
of
either
­
9
or
­
10
months.

Although
acceptable,
the
rotational
crop
study
had
some
deficiencies.
The
foliage
of
the
legume
and
potato
vegetables
were
not
analyzed
for
atrazine
residues
in
the
study.
Table
1
of
OPPTS
Residue
Chemistry
Test
Guidelines
lists
the
leafy
tops
of
legumes,
such
as
soybeans,
as
feed
commodities.
Since
the
registrant
intends
to
have
soybeans
as
a
rotational
crop
after
corn
additional
data
on
soybean
foliage
are
required.
In
addition,
the
treatment
regime
for
corn
used
in
the
field
accumulation
study
on
potatoes
and
shelled
pea
and
bean
did
not
include
the
following
regime:
0.5
lbs
ai/
A
pre­
emergence
followed
by
a
2.0
lbs
ai/
A
post­
emergence
for
a
maximum
rate
of
2.5
lbs
ai/
A.
Although
the
study
did
include
a
regime
resulting
in
the
maximum
labeled
seasonal
rate
of
2.5
lbs
ai/
A,
the
regime
used
did
not
include
the
maximum
labeled
post­
emergence
rate
of
2.0
lbs
ai/
A.
This
treatment
regime
although
only
used
on
~
22%
of
corn
acres
treated
with
atrazine
may
lead
to
the
greatest
residues
in
rotational
crops.

The
results
suggest
that
a
plantback
interval
of
10
months
could
be
established
for
potatoes.
Even
though
the
foliage
of
potatoes
was
not
harvested
and
analyzed,
because
the
foliage
of
potatoes
is
not
considered
an
animal
feed
item,
HED
recommends
the
PBI
for
potatoes
be
changed
to
10
months
as
requested.
The
foliage
of
pea
and
bean
crops
were
also
not
harvested
and
analyzed
for
atrazine
residues.
As
foliage
of
some
legume
vegetables
(
soybeans)
is
considered
an
animal
feedstuff
in
Table
1
of
OPPTS
860.1000,
residue
data
on
the
foliage
of
legumes
are
required
before
HED
can
reconsider
the
established
PBI
of
12
months.
HED
recommends
that
the
PBI
for
legume
vegetables
represented
by
shelled
pea
and
bean
planted
after
corn
be
retained
at
12
months
as
exists
on
the
current
label
until
the
registrant
conducts
and
submits
field
trials
on
the
foliage
of
legume
vegetables
(
Crop
Group
7)
as
required
in
the
HED
Product
and
Residue
Chemistry
Chapter
for
the
Interim
Reregistration
Eligibility
Decision
(
iRED)
for
Atrazine.

The
HED
Product
and
Residue
Chemistry
Chapter
of
the
Interim
Reregistration
Eligibility
Decision
(
iRED)
for
Atrazine
requires
additional
field
trials
for
the
foliage
of
legume
vegetables
to
set
a
tolerance
for
inadvertent
atrazine
residues
in
soybean
forage
as
described
in
OPPTS.
GLN
860.1900.
These
field
trial
data
can
then
be
used
to
set
a
tolerance
for
inadvertent
residues
of
atrazine
in
foliage
of
legumes
used
as
rotational
crops,
and
used
as
animal
feed.
Upon
receipt
and
review
of
the
study
HED
can
reconsider
the
need
for
the
existing
12­
month
PBI
for
legume
vegetables.
This
data
requirement
is
based
on
quantifiable
chlorotriazine
residues
detected
in
soybean
forage
collected
from
a
NY
test
using
a
12­
month
plant
back
interval
(
PBI).
6
Chlorotriazine
residues
were
detected
at
0.08
to
0.12
ppm.
In
addition,
hydroxy
triazine
residues
were
detected
in
soybean
forage
sample
at
0.03
ppm
from
the
12­
month
PBI
trial
in
NY.

Drinking
Water
Risk
Estimates
Reduction
of
FQPA
Safety
Factor
and
Reassessment
of
DWLOC
Value
for
use
in
Human
Health
Risk
Assessment:

HED's
April
16,
2002:
Revised
Human
Health
Risk
Assessment
for
the
Reregistration
Eligibility
Decision
(
RED)
document
used
a
screening­
level
approach
to
identify
community
water
systems
(
CWS)
with
high­
end
seasonal
exposures
to
atrazine
and
the
chlorinated
metabolites
(
or
total
chlorotriazines).
Under
the
screening­
level
approach,
a
drinking
water
level
of
comparison
(
DWLOC)
was
established
at
12.
5
ppb
for
total
chlorotriazines.
This
DWLOC
is
not
and
was
not
used
as
a
drinking
water
standard
in
the
risk
assessment,
but
rather
as
a
screening
tool
to
identify
specific
community
water
systems
which
may
be
of
concern.

In
the
risk
assessment,
37
CWS
were
identified
with
90­
day
average
chlorotriazine
concentrations
above
the
screening
DWLOC
of
12.5
ppb.
These
CWS
were
targeted
for
intensive
monitoring,
risk
mitigation,
and
probabilistic
risk
assessments.
In
addition,
this
90­
day
average
screening
DWLOC
of
12.5
ppb
also
served
as
a
tool
in
the
risk
mitigation
process
to
establish
a
trigger
value
by
which
CWS
with
potential
high­
end
seasonal
exposures
could
be
identified
in
the
future
based
on
compliance
monitoring
data
collected
under
the
Safe
Drinking
Water
Act
(
SDWA).
Data
available
through
the
SDWA
compliance
monitoring
typically
consist
of
quarterly
samples
and
are
reported
as
an
annual
average.
HED
and
EFED
considered
available
data
from
SDWA
compliance
monitoring
and
came
to
agreement
with
the
registrant
on
a
trigger
value
of
2.6
ppb
based
on
an
annual
average
concentration
in
finished
water
which
is
considered
predictive
of
the
likelihood
that
a
90­
day
average
during
peak
use
season
would
exceed
the
screening
DWLOC
of
12.5
ppb.
CWS
identified
in
the
future
with
potential
high­
end
seasonal
exposures
based
on
the
annual
average
trigger
of
2.6
ppb
will
receive
intensive
monitoring
under
the
Memorandum
of
Agreement
between
OPP
and
the
registrant.
It
should
be
noted
that
the
annual
average
trigger
of
2.6
ppb
is
for
total
chlorotriazines.
Therefore,
all
SDWA
compliance
monitoring
data
must
first
be
transformed
from
a
value
representing
atrazine
alone,
to
a
concentration
which
reflects
inclusion
of
degradates
of
concern
using
the
appropriate
seasonal
regression
equations
described
in
the
April
16,
2002
risk
assessment
document.

The
screening
level
DWLOC
of
12.5
ppb
is
based
on
an
endpoint
of
1.8
mg/
kg/
day
and
a
1000­
fold
uncertainty
factor.
The
1000­
fold
uncertainty
factor
includes
a
10­
fold
factor
for
interspecies
variation,
a
10­
fold
factor
for
intraspecies
variability,
and
a
10­
fold
FQPA
safety
7
factor.
The
10­
fold
safety
factor
was
applied
to
account
for
the
residual
uncertainty
associated
with
atrazine's
toxic
effects
on
the
developing
child
and
the
extent
and
magnitude
of
exposure
to
atrazine
in
drinking
water.
Therefore,
the
10­
fold
safety
factor
reflects
uncertainties
regarding
both
the
hazard
and
exposure
portions
of
the
human
health
risk
assessment.

Community
water
systems
found
to
be
potentially
impaired
by
atrazine,
as
predicted
by
exceedences
in
the
transformed
SDWA
annual
average
concentration,
as
compared
to
the
trigger
value
of
2.6
ppb,
will
be
subject
to
an
intensive
monitoring
program.
This
intensive
monitoring
program
will
include
weekly
sampling
for
atrazine
during
the
use
season
(
exact
time
frame
to
be
determined)
and
biweekly
sampling
for
atrazine
during
the
remainder
of
the
year.
Total
chlorotriazine
concentrations
for
each
sample
taken
will
be
estimated
through
the
application
of
the
appropriate
quarterly
linear
regression
equations
as
described
in
the
April
16,
2002
risk
assessment
document.
As
a
quality
assurance/
quality
control
check
on
this
method
of
estimation,
10%
of
the
samples
taken
will
be
analyzed
specifically
for
the
chlorinated
degradates:
desethyl
atrazine,
desisopropyl
atrazine,
and
diaminochlorotriazine
by
GC/
MS
to
ensure
that
the
regression
method
of
estimation
of
total
chlorotriazines
is
accurate.
This
monitoring
program
will
determine
the
maximum
90­
day
average
chlorotriazine
concentration
with
sufficient
accuracy
to
allow
removal
of
that
portion
of
the
10­
fold
FQPA
safety
factor
associated
with
residual
uncertainties
regarding
the
extent
and
magnitude
of
drinking
water
exposure,
thereby
reducing
the
10­
fold
safety
factor
to
3­
fold
for
the
risk
assessments
conducted
in
those
community
water
systems
for
which
there
is
available,
reliable
drinking
water
exposure
data.

For
those
specific
CWS
undergoing
or
preparing
to
undergo
intensive
monitoring,
residual
uncertainties
regarding
the
extent
and
magnitude
of
exposure
to
chlorotriazines
have
been
removed,
therefore
supporting
a
reduction
in
the
FQPA
safety
factor
to
3X.
Based
on
the
availability
of
reliable
drinking
water
exposure
data,
HED
has
recalculated
the
DWLOC
(
drinking
water
level
of
concern)
using
a
total
risk
assessment
300­
fold
uncertainty
factor
for
those
CWS
currently
undergoing
or
targeted
for
future
intensive
monitoring.
For
these
CWS,
the
DWLOC
becomes
37.5
ppb
for
total
chlorotriazines
based
on
an
endpoint
of
1.8
mg/
kg/
day,
and
a
300­
fold
uncertainty
factor
reflecting
a
10­
fold
factor
for
interspecies
variation,
a
10­
fold
factor
for
intraspecies
variability,
and
a
3­
fold
safety
factor.
The
3­
fold
safety
factor
reflects
residual
uncertainties
associated
with
atrazine's
toxic
effects
on
the
developing
child
only.
For
CWS
without
intensive
monitoring
as
described
above,
the
screening
level
DWLOC
remains
12.5
ppb
for
total
chlorotriazines.

Probabilistic
Risk
Assessments
for
11
Additional
CWS:

Syngenta
submitted
a
probabilistic
exposure
assessment
for
11
additional
community
water
8
systems
(
CWS)
identified
in
the
revised
human
health
risk
assessment
(
April
16,
2002).
The
exposure
assessment
was
conducted
using
the
same
exposure
model
and
methodology
as
used
in
the
revised
human
health
risk
assessment
as
discussed
in
Appendix
II
of
that
document.
For
details
on
how
this
assessment
was
conducted
please
refer
to
Appendix
II
of
the
revised
human
health
risk
assessment.

Of
the
11
CWS
included
in
this
assessment,
7
were
identified
in
the
revised
risk
assessment
with
potential
to
exceed
levels
of
concern,
i.
e.,
90­
day
average
concentration
of
chlorotriazines
of
12.5
ppb
based
on
quarterly
maximum
value
of
12.5
ppb
or
greater
as
obtained
from
compliance
monitoring
data
(
PLEX
database).
The
additional
4
CWS
were
identified
with
potential
to
exceed
levels
of
concern,
i.
e.,
90­
day
average
concentration
of
chlorotriazines
of
12.5
ppb
based
on
a
screening­
level
deterministic
assessment.
Probabilistic
exposure
assessments
were
not
conducted
for
these
11
CWS
previously.

The
results
of
that
assessment
are
presented
below.

Results
of
Risk
Analysis
of
Syngenta'
s
PRA
for
11
CWS:
Maximum
99.9th
Percentile
Exposure
Based
on
a
Rolling
90­
Day
Average
and
%
cPAD*
for
Populations
of
Interest
CWS
Adults
13
­
50
Children
7
­
12
Children
1
­
6
Infants
<
1
Exposure
mg/
kg/
day
%
cPAD
Exposure
mg/
kg/
day
%
cPAD
Exposure
mg/
kg/
day
%
cPAD
Exposure
mg/
kg/
day
%
cPAD
Omaha,
IL1
0.0013
72%
0.0012
66%
0.0020
111%
0.0045
250%

Carthage,
IL1
0.00026
14%
0.00023
13%
0.00038
21%
0.00088
49%

Fort
Wayne,
IN1
0.00034
19%
0.00028
16%
0.00048
27%
0.0012
67%

Marion,
KY2
0.0016
89%
0.0015
83%
0.0023
128%
0.0057
317%

Lewisburg,
KY2
0.0016
89%
0.0015
83%
0.0023
128%
0.0057
317%

Dearborn,
MO2
0.0028
155%
0.0027
150%
0.0041
228%
0.01
555%

Drexel,
MO2
0.00042
22%
0.00041
22%
0.00063
33%
0.0015
83%

Village
of
Mt.
Orab,
OH1
0.0011
62%
0.0009
52%
0.0016
89%
0.0036
200%

Village
of
Williamsburg,
OH1
0.0015
83%
0.0013
72%
0.0022
122%
0.0052
289%

Clermont
Co.,
OH1
0.0007
39%
0.0007
39%
0.0011
61%
0.0026
144%
Results
of
Risk
Analysis
of
Syngenta'
s
PRA
for
11
CWS:
Maximum
99.9th
Percentile
Exposure
Based
on
a
Rolling
90­
Day
Average
and
%
cPAD*
for
Populations
of
Interest
CWS
Adults
13
­
50
Children
7
­
12
Children
1
­
6
Infants
<
1
Exposure
mg/
kg/
day
%
cPAD
Exposure
mg/
kg/
day
%
cPAD
Exposure
mg/
kg/
day
%
cPAD
Exposure
mg/
kg/
day
%
cPAD
9
Delaware,
OH1
0.0009
50%
0.0007
39%
0.0013
72%
0.0028
155%

1
Identified
in
April
16,
2002,
"
Atrazine.
HED's
Revised
Human
Health
Risk
Assessment
for
the
Reregistration
Eligibility
Decision
(
RED)"
as
one
of
52
additional
CWS
using
surface
water
with
potential
to
exceed
levels
of
concern,
i.
e.,
90­
day
average
concentration
of
chlorotriazines
of
12.5
ppb
based
on
quarterly
maximum
value
of
12.5
ppb
or
greater
as
obtained
from
compliance
monitoring
data
(
PLEX
DATABASE).

2
Identified
in
April
16,
2002,
"
Atrazine.
HED's
Revised
Human
Health
Risk
Assessment
for
the
Reregistration
Eligibility
Decision
(
RED)"
as
one
of
four
CWS
using
surface
water
with
potential
to
exceed
levels
of
concern,
i.
e.,
90­
day
average
concentration
of
chlorotriazines
of
12.5
ppb
based
on
a
screening­
level
deterministic
assessment.

*
cPAD
=
0.0018
mg/
kg/
day
and
is
the
chronic
population
adjusted
dose
and
is
used
for
estimating
intermediate­
term
and
chronic
risks
As
a
result
of
this
probabilistic
exposure
assessment
for
these
additional
11
CWS,
HED
has
revised
the
number
of
CWS
with
risk
estimates
exceeding
levels
of
concern.
Previously,
HED
identified
29
CWS
using
surface
water
of
concern.
HED
has
revised
that
number
to
34
CWS.
These
34
CWS
are:
Shipman,
Gillespie,
Hettick,
Salem,
Palmyra­
Modesto,
Hillsboro,
Farina,
Kinmundy,
ADGPTV,
Carlinville,
West
Salem,
Flora,
Sorento,
White
Hall,
Louisville,
Centralia,
and
Omaha
in
Illinois,
Chariton
in
Iowa,
Iberville
in
Louisiana,
Batesville,
Holland,
North
Vernon,
and
Scottsburg
in
Indiana,
Lewisburg,
and
Marion
in
Kentucky,
Bucklin,
Dearborn,
and
Vandalia
in
Missouri,
Newark,
Sardinia,
Mt.
Orab,
Williamsburg,
Clermont,
and
Delaware
in
Ohio.

The
CWS
added
are
italicized
in
the
paragraph
above,
and
the
CWS
removed
from
the
original
list
is
located
in
Drexel,
Missouri.
An
updated
version
of
Table
A
­
II
­
1
below
contains
the
names
and
estimated
risks
for
each
CWS
with
risk
estimates
of
concern
at
the
99.9th
percentile
of
exposure.
[*
Note:
The
CWS
located
in
Shipman,
IL
is
not
included
in
the
table
below
as
it
no
longer
serves
as
a
drinking
water
source.
However,
it
is
being
retained
as
a
candidate
CWS
for
risk
mitigation.]
10
Table
A
­
II
­
1.
Updated
from
Appendix
II
of
Atrazine:
Revised
Human
Health
Risk
Assessment.
Risk
Estimates
for
High
Seasonal
Exposures
to
Atrazine
in
Finished
Drinking
Water
and
Average
Dietary
Exposure
@
the
99.9th
Percentile
of
Exposure*
(
Calandex
 
)

Community
Water
System
(
City/
State)
Infant's
Exposure
(
mg/
kg/
day)
%
cPAD
Children's
Exposure
(
mg/
kg/
day)
%
cPAD
Adult's
Exposure
(
mg/
kg/
day)
%
cPAD
Chariton,
IA
0.0042
235%
0.0015
<
100%
0.0011
<
100%

Sorento,
IL
0.0033
183%
0.0013
<
100%
0.0010
<
100%

Flora,
IL
0.0038
211%
0.0017
<
100%
0.0012
<
100%

W.
Salem,
IL
0.0034
189%
0.0018
100%
0.0014
<
100%

Farina,
IL
0.0034
189%
0.0012
<
100%
0.0008
<
100%

White
Hall,
IL
0.0050
278%
0.0021
117%
0.0014
<
100%

Carlinville,
IL
0.0023
128%
0.0011
<
100%
0.0008
<
100%

Gillespie,
IL
0.0099
550%
0.0040
222%
0.0031
172%

Hettick,
IL
0.0098
544%
0.0040
222%
0.0031
172%

Palmyra­
Modesto,
IL
0.0063
350%
0.0028
155%
0.0020
111%

N.
Otter
Twp
ADGPTV,
IL
0.0034
189%
0.0015
<
100%
0.0010
<
100%

Kinmundy,
IL
0.0027
150%
0.0011
<
100%
0.0008
<
100%

Salem,
IL
0.0095
528%
0.0048
267%
0.0036
200%

Centralia,
IL
0.0046
255%
0.0018
100%
0.0013
<
100%

Hillsboro,
IL
0.0049
272%
0.0021
117%
0.0015
<
100%

Louisville,
IL
0.0062
344%
0.0022
122%
0.0017
<
100%

Holland,
IN
0.0044
244%
0.0023
128%
0.0017
<
100%

North
Vernon,
IN
0.0036
200%
0.0021
117%
0.0014
<
100%

Batesville,
IN
0.0047
261%
0.0020
111%
0.0014
<
100%

Scottsburg,
IN
0.0048
267%
0.0027
150%
0.0019
105%

Iberville,
LA
0.0047
261%
0.0021
117%
0.0015
<
100%

Bucklin,
MO
0.0045
250%
0.0018
100%
0.0012
<
100%
Table
A
­
II
­
1.
Updated
from
Appendix
II
of
Atrazine:
Revised
Human
Health
Risk
Assessment.
Risk
Estimates
for
High
Seasonal
Exposures
to
Atrazine
in
Finished
Drinking
Water
and
Average
Dietary
Exposure
@
the
99.9th
Percentile
of
Exposure*
(
Calandex
 
)

Community
Water
System
(
City/
State)
Infant's
Exposure
(
mg/
kg/
day)
%
cPAD
Children's
Exposure
(
mg/
kg/
day)
%
cPAD
Adult's
Exposure
(
mg/
kg/
day)
%
cPAD
11
Vandalia,
MO
0.0034
189%
0.0019
105%
0.0013
<
100%

Sardinia,
OH
0.012
667%
0.0055
305%
0.0037
205%

Marion,
KY2
0.0057
317%
0.0023
128%
0.0016
<
100%

Lewisburg,
KY2
0.0057
317%
0.0023
128%
0.0016
<
100%

Dearborn,
MO2
0.01
555%
0.0041
228%
0.0028
155%

Village
of
Mt.
Orab,
OH1
0.0036
200%
0.0016
<
100%
0.0011
<
100%

Village
of
Williamsburg,
OH1
0.0052
289%
0.0022
122%
0.0015
<
100%

Clermont
Co.,
OH1
0.0026
144%
0.0011
<
100%
0.0007
<
100%

Delaware,
OH1
0.0028
155%
0.0013
<
100%
0.0009
<
100%

Omaha,
IL1
0.0045
250%
0.0020
111%
0.0013
<
100%

Newark,
OH
0.0020
111%
0.0009
<
100%
0.0006
<
100%

1
Identified
in
April
16,
2002,
"
Atrazine.
HED's
Revised
Human
Health
Risk
Assessment
for
the
Reregistration
Eligibility
Decision
(
RED)"
as
one
of
52
additional
CWS
using
surface
water
with
potential
to
exceed
levels
of
concern,
i.
e.,
90­
day
average
concentration
of
chlorotriazines
of
12.5
ppb
based
on
quarterly
maximum
value
of
12.5
ppb
or
greater
as
obtained
from
compliance
monitoring
data
(
PLEX
DATABASE).

2
Identified
in
April
16,
2002,
"
Atrazine.
HED's
Revised
Human
Health
Risk
Assessment
for
the
Reregistration
Eligibility
Decision
(
RED)"
as
one
of
four
CWS
using
surface
water
with
potential
to
exceed
levels
of
concern,
i.
e.,
90­
day
average
concentration
of
chlorotriazines
of
12.5
ppb
based
on
a
screening­
level
deterministic
assessment.

*
cPAD
=
0.0018
mg/
kg/
day
and
is
the
chronic
population
adjusted
dose
and
is
used
for
estimating
intermediate­
term
and
chronic
risks
12
The
following
table
provides
a
listing
of
CWS
and
percentages
of
the
PAD
exceeded,
and
the
year
of
the
exceedence.

Community
Water
System
(
City/
State)
Year(
s)
of
Exceedence
Infants
<
1
year
old
%
cPAD
Children
%
cPAD
Adults
%
cPAD
Chariton,
IA
1998
235%
<
100%
<
100%

Sorento,
IL
1996
183%
<
100%
<
100%

Flora,
IL
1996
211%
<
100%
<
100%

W.
Salem,
IL
1996
189%
100%
<
100%

Farina,
IL
1993
189%
<
100%
<
100%

White
Hall,
IL
1996
278%
117%
<
100%

Carlinville,
IL
1996
128%
<
100%
<
100%

Gillespie,
IL
1996
550%
222%
172%

Hettick,
IL
1994,
1996,
1998,
2001
544%
222%
172%

Palmyra­
Modesto,
IL
1993,
1994
350%
155%
111%

N.
Otter
Twp
ADGPTV,
IL
1993,
1994
189%
<
100%
<
100%

Kinmundy,
IL
1993
150%
<
100%
<
100%

Salem,
IL
1993,
1994
528%
267%
200%

Centralia,
IL
1996
255%
100%
<
100%

Hillsboro,
IL
1994
272%
117%
<
100%

Louisville,
IL
NA
344%
122%
<
100%

Holland,
IN
1996
244%
128%
<
100%

North
Vernon,
IN
1996
200%
117%
<
100%

Batesville,
IN
1997
261%
111%
<
100%

Scottsburg,
IN
1996
267%
150%
105%

Iberville,
LA
1996,
1997,
2001
261%
117%
<
100%

Bucklin,
MO
1997
250%
100%
<
100%

Vandalia,
MO
1996
189%
105%
<
100%

Sardinia,
OH
1996
667%
305%
205%

Marion,
KY2
1999
317%
128%
<
100%
Community
Water
System
(
City/
State)
Year(
s)
of
Exceedence
Infants
<
1
year
old
%
cPAD
Children
%
cPAD
Adults
%
cPAD
13
Lewisburg,
KY2
1999
317%
128%
<
100%

Dearborn,
MO2
1994,
1999
555%
228%
155%

Village
of
Mt.
Orab,
OH1
1997
200%
<
100%
<
100%

Village
of
Williamsburg,
OH1
1996
289%
122%
<
100%

Clermont
Co.,
OH1
1997
144%
<
100%
<
100%

Delaware,
OH1
1997
155%
<
100%
<
100%

Omaha,
IL1
1996
250%
111%
<
100%

Newark,
OH
NA
111%
<
100%
<
100%

NA
­
Not
available
Additional
Compliance
Monitoring
Data:

Syngenta
submitted
additional
compliance
monitoring
data
for
several
additional
states
not
submitted
or
considered
in
the
revised
human
health
risk
assessment.
These
data
are
summarized
below.

Syngenta
submitted
compliance
monitoring
data
on
atrazine
and
estimates
of
total
chlorotriazines
(
atrazine
+
desethyl
atrazine,
desisopropyl
atrazine,
and
diaminochlorotriazine)
as
collected
under
the
Safe
Drinking
Water
Act
(
SDWA)
for
CWS
in
10
additional
states
from
1993
to
1999.
These
10
states
are
considered
to
have
low­
use
of
atrazine.
These
states
are:
AL,
AR,
CO,
GA,
NM,
OK,
SC,
SD,
TN,
and
VA.
These
10
states
in
conjunction
with
the
21
states
previously
considered
in
the
revised
human
health
risk
assessment
represent
>
99%
of
atrazine
use.
The
number
of
CWS
reporting
data
on
atrazine
in
these
10
additional
low­
use
atrazine
states
varied.
Not
all
of
the
states
provided
monitoring
data
for
each
of
the
7
years
between
1993
and
1999.
The
state
of
VA
provided
data
for
only
1
CWS
sampled
one
time
in
1997.
The
number
of
CWS
collecting
data
on
atrazine
decreased
with
time
over
the
7­
year
period.
However,
between
1993
and
1999,
the
total
number
of
CWS
collecting
monitoring
data
on
atrazine
across
these
10
states
ranged
from
a
low
of
125
in
1999
to
a
high
of
288
in
1993.
The
number
of
samples
collected
at
each
of
these
CWS
ranged
from
1
to
4
per
year.

The
maximum
concentrations
for
total
chlorotriazines
for
each
CWS
for
each
year
of
monitoring
data
provided
were
compared
to
12.5
ppb.
None
of
the
samples
contained
concentrations
of
14
total
chlorotriazines
greater
than
or
equal
to
12.5
ppb.
Consequently,
HED
did
not
identify
any
additional
CWS
of
potential
concern
based
on
compliance
monitoring
data
from
these
10
states.

Additional
compliance
monitoring
data
were
submitted
for
1999
for
the
21
states
originally
assessed
in
the
revised
human
health
risk
assessment,
and
for
the
year
2000
for
a
combination
of
states.
The
maximum
concentrations
for
total
chlorotriazines
for
each
CWS
for
each
year
of
monitoring
data
provided
were
compared
to
12.5
ppb.
Three
(
3)
CWS
had
samples
with
concentrations
of
total
chlorotriazines
greater
than
or
equal
to
12.5
ppb.
These
3
CWS
have
been
added
to
the
updated
version
of
Table
A
­
III
­
1
contained
in
Appendix
III
of
the
April
16,
2002
revised
human
health
risk
assessment.

The
submitted
probabilistic
exposure
assessment
also
impacted
the
number
of
CWS
identified
as
of
potential
concern
as
contained
in
Appendix
III
of
the
revised
human
health
risk
assessment.
As
a
result
of
the
probabilistic
exposure
assessment
on
the
11
CWS,
and
the
additional
compliance
monitoring
data
submitted,
approximately
50
CWS
are
now
considered
to
have
the
potential
to
exceed
12.5
ppb
of
chlorotriazines
over
a
consecutive
90­
day
period.
An
updated
version
of
Table
A
­
III
­
1
contained
in
Appendix
III
reflecting
these
changes
is
provided
below.

Table
A
­
III
­
1.
Updated
from
Appendix
III
from
April
16,2002
Atrazine:
Revised
Human
Health
Risk
Assessment.
Community
Water
Systems
(
CWS)
with
Quarterly
Maximum
Concentrations
of
Atrazine
plus
Chloro­
Metabolites
Equal
to
or
Greater
than
12.5
ppb
Year
CWS
Concentrations
(
ppb)
Comment
2000
Versailles,
IN
15.12
2000
Bedford,
IN
13.41
1999
Napoleon,
OH
17.35
Self
1999
Corsicana,
TX
15.37
1998
Kansas
City,
KS
14.42
Self
1998
Defiance,
OH
13.63
Self
1998
Ayersville,
OH
13.63
Purchases
from
Defiance
1998
Cristi
Meadows
Subdivision,
OH
13.63
Purchases
from
Defiance
1998
Brunersburg,
OH
13.63
Purchases
from
Defiance
1998
Village
of
Blanchester,
OH
12.47
Self
1998
Glasgow,
MO
15.69
Self
Table
A
­
III
­
1.
Updated
from
Appendix
III
from
April
16,2002
Atrazine:
Revised
Human
Health
Risk
Assessment.
Community
Water
Systems
(
CWS)
with
Quarterly
Maximum
Concentrations
of
Atrazine
plus
Chloro­
Metabolites
Equal
to
or
Greater
than
12.5
ppb
Year
CWS
Concentrations
(
ppb)
Comment
15
1998
Howard
Co.
PWD
#
2
15.69
Purchase
from
Glasgow
1998
Waverly,
IL
Self
1997
Newark,
OH
29.7
Self
1997
Lake
of
the
Woods
18.1
Self
1997
Napoleon,
OH
17.9
Self
1997
Liberty
Center,
OH
17.9
Purchased
water
from
Napoleon
1997
Florida
City,
OH
17.9
Purchased
water
from
Napoleon
1997
Village
of
Malinta,
OH
17.9
Purchased
water
from
Napoleon
1997
Aquilla
Water
Supply
District,
TX
15.13
Self
1997
Brandon­
Irene
Water
Supply
Corp.
TX
15.13
Self
1997
Chatt
Water
Supply
Corp.,
TX
15.13
Self
1997
Files
Valley
Water
Corp.
15.13
Self
1997
Hill
Co.
Water
Corp.,
TX
15.13
Self
1997
Milford
City,
TX
15.13
Self
1997
City
of
Bynum,
TX
15.13
Self
1997
Piqua,
OH
14.31
Self
1996
Napoleon,
OH
14.65
Self/
supplier
1996
Louisville,
IL
24.3
1996
Osawatomie,
KS
17.3
1996
Miami
Co.
RWD
#
1,
KS
17.3
Purchased
water
from
Osawatomie
1996
Miami
Co.
RWD
#
3,
KS
17.3
Purchased
water
from
Osawatomie
1996
City
of
Osage,
KS
15.84
Self
1996
Osage
Co.
RWD
#
7,
KS
15.84
Purchased
from
City
of
Osage
1996
City
of
Reading
15.84
Purchased
from
City
of
Osage
1996
Osage
Co.
RWD
#
6,
KS
15.84
Purchased
from
City
of
Osage
Table
A
­
III
­
1.
Updated
from
Appendix
III
from
April
16,2002
Atrazine:
Revised
Human
Health
Risk
Assessment.
Community
Water
Systems
(
CWS)
with
Quarterly
Maximum
Concentrations
of
Atrazine
plus
Chloro­
Metabolites
Equal
to
or
Greater
than
12.5
ppb
Year
CWS
Concentrations
(
ppb)
Comment
16
1996
City
of
Upper
Sandusky,
OH
14.38
Self
1996
Keysport,
IL
14.42
Self
1994
Andersen
Co.,
RWD
#
2,
KS
15.84
Self
1994
Keysport,
IL
18.7
Self
1994
Emma,
MO
14.42
Self
1994
Louisville,
IL
18.7
Self
1994
Vandali,
IL
13.29
Self
1994
Canton
12.71
Self
1994
Cuba,
IL
12.71
Purchases
from
Canton
1994
Norris,
IL
Purchases
from
Canton
1994
Dunfer,
IL
Purchases
from
Canton
1993
Three
Rivers,
IN*
20.1
1993
New
Haven,
IN
20.1
Purchased
water
from
Three
Rivers
1993
Sunymede,
IN
20.1
Purchased
water
from
Three
Rivers
The
CWS
serving
Three
Rivers,
IN
was
not
included
in
the
VMS
databases
available
to
HED.
17
Occupational
and
Residential
Exposure
and
Risk
Assessments
Based
on
the
registrant's
comments
received
during
the
60­
day
comment
period
changes
have
been
made
to
the
occupational
and
residential
exposure
assessment
document.
The
revised
document,
"
Atrazine:
Revised
Occupational
and
Residential
Exposure
Assessment
and
Recommendations
for
the
Reregistration
Eligibility
Decision",
August
30,
2002
(
ORE
assessment)
and
the
Addendum
to
the
revised
ORE
assessment
(
D287742)
dated
1/
31/
2003
now
reflect
those
changes.
Sections
of
the
atrazine
human
health
risk
assessment
dated
April
16,
2002
must
also
reflect
those
changes.
Rather
than
rewrite
the
human
health
risk
assessment,
the
appropriate
sections
to
which
changes
have
been
made
are
excerpted
here.

Section
4.4
­
Residential
Exposure
and
Risk
Assessment
The
first
paragraph
and
list
of
exposure
scenarios
should
now
read:

Atrazine
is
labeled
for
homeowner
use
to
control
weeds
in
turf
grasses
that
are
generally
specific
to
the
Southeast,
i.
e.,
zyosia,
and
bermuda
grasses.
Homeowners
applying
atrazine
products
to
their
lawns
may
be
exposed
to
atrazine
through
their
skin
(
dermal)
and
by
inhaling
dusts
or
sprays
(
inhalation)
during
application.
Residential
exposures
to
atrazine
are
expected
to
be
short­
term
in
duration
from
1
day
to
a
maximum
of
2
to
3
weeks.
Intermediate­
term
exposures
greater
than
30
days
in
duration
are
not
anticipated
from
residential
uses
of
atrazine.
The
following
five
residential
handler
exposure
scenarios
were
evaluated:

(
1)
mixing,
loading,
and
applying
liquid
formulations
using
a
backpack
sprayer,
(
2)
mixing,
loading,
and
applying
liquid
formulations
with
a
low
pressure
hand
wand,
(
3)
mixing,
loading,
and
applying
liquid
(
ready­
to­
use)
formulations
with
a
hose­
end
sprayer,
(
4)
mixing,
loading,
and
applying
granulated
formulations
with
a
push­
type
spreader,
(
5)
mixing,
loading,
and
applying
granulated
formulations
with
a
belly
grinder.

Section
4.4.2
­
Post
Application
Exposure
and
Risk
Estimates
The
fourth
paragraph
should
now
read:

A
total
of
8
dermal
postapplication
exposure
scenarios
were
evaluated.
All
of
these
scenarios
,
involving
exposure
following
application
of
a
liquid
and
granular
formulations,
had
short­
term
dermal
MOEs
greater
than
300,
for
high­
contact
activities
on
turf
for
children
and
adults.
The
lowest
MOEs
of
310
for
children
and
510
for
adults
are
based
on
average
residues
for
the
day
of
application
at
two
sites
(
NC
and
GA)
each
receiving
liquid
formulations
at
2
lbs
ai/
A.
Residues
18
had
dissipated
sufficiently
on
the
day
after
treatment
to
raise
MOEs
for
children
to
750
and
adults
to
1300.
For
adults
golfing
and
mowing
on
treated
turf,
all
short­
term
dermal
MOEs
exceeded
300.

The
sixth
paragraph
has
been
expanded
to
the
following:

Adults
may
reasonably
be
expected
to
perform
more
than
one
activity
on
treated
lawns
in
a
single
day,
but
an
eight­
hour
duration
of
exposure
is
unlikely.
Therefore,
it
is
reasonable
to
aggregate
the
exposures
from
playing/
gardening
(
highest
exposure
rate),
walking,
and
mowing
(
lower
exposure
rate)
for
a
single
MOE.
The
MOE
for
all
adult
post­
application
exposures
aggregated
from
liquid
applications
at
2
lbs
ai/
A
is
460
and
is
above
HED's
level
of
concern.
It
is
also
possible
that
an
adult
would
apply
herbicide
spray
to
a
lawn
and
then
play
on
it
or
mow
it
later
that
day.
In
such
an
event,
the
aggregated
dermal
MOE
for
the
day
would
be
slightly
lower
than
the
target
300
for
that
day.
Based
on
the
liquid
application
study
values
for
adult
handler
and
adult
post­
application
exposures,
the
aggregate
MOE
for
dermal
exposures
is
270.
[
See
table
14b
from
the
August
30,
2002
document
(
1/[
1/
460
+
1/
640]
=
270)].
However,
this
aggregate
exposure
scenario
is
not
very
likely
and
is
considered
a
high­
end
estimate
of
exposure.
If
the
liquid
formulation
application
rates
are
reduced
to
1
lb
ai/
A,
the
resulting
MOE
for
estimates
of
dermal
exposures
result
in
a
MOE
of
610
for
children
and
greater
than
1000
for
adults.
Combined
dermal
exposures
for
adults
at
a
1
lb
ai/
A
rate
result
in
a
risk
estimate
of
860
and
that
does
not
exceed
HED's
level
of
concern.
Aggregate
risk
estimates
for
adults
applying
and
playing
on
lawns
treated
at
the
2
lbs
ai/
A
rate
based
on
the
granular
residue
data
do
not
exceed
HED's
level
of
concern.

At
the
2
lb
ai/
A
application
rate,
incidental
oral
(
non­
dietary)
risk
estimates
exceed
HED's
level
of
concern
for
toddlers
incidental
oral
exposures
on
lawns
treated
with
liquid
formulations.
Risk
estimates
are
210
for
hand­
to­
mouth
activity
and
200
for
combined
oral
(
non­
dietary)
exposures.
Risk
estimates
do
not
exceed
HED's
level
of
concern
for
toddlers
incidental
oral
exposures
on
lawns
treated
with
granular
formulations.
Risk
estimates
are
950
for
hand­
to­
mouth
activity
and
730
for
combined
oral
(
non­
dietary)
exposures.
It
is
considered
reasonably
likely
that
dermal
and
oral
incidental
exposures
may
occur
in
the
same
day
for
children
playing
on
atrazine­
treated
lawns.
It
can
be
seen
from
calculations
presented
in
Table
11
that
the
incidental
hand­
to­
mouth
exposure
estimate
constitutes
most
of
the
total
non­
dietary
oral
dose.
The
overall
incidental
oral
MOE
is
only
slightly
less
(
200
for
spray,
730
for
granular)
than
the
MOE
for
the
hand­
tomouth
estimate
(
210
spray;
950
granular).
Since
the
individual
oral
route
of
exposure
on
sprayed
turf
exceeds
the
level
of
concern,
adding
the
dermal
exposure
to
the
oral
exposures
produces
an
even
lower
MOE
of
125,
which
exceeds
HED's
level
of
concern.
Granular
exposures
result
in
a
19
total
MOE
for
dermal
plus
oral
incidental
exposures
of
at
least
350,
which
does
not
exceed
HED's
level
of
concern.
These
route­
specific
and
dermal
plus
oral
aggregated
doses
and
MOEs
were
calculated
for
the
purposes
of
the
overall
risk
assessment
for
this
chemical,
which
will
consider
all
routes
of
exposure.
Finally,
ingestion
of
granules,
as
explained
earlier,
is
not
aggregated
because
it
is
considered
an
infrequent,
episodic
event.

If
the
liquid
formulation
application
rates
are
reduced
to
1
lb
ai/
A,
the
resulting
MOE
for
toddlers'
hand­
to­
mouth
exposures
is
420,
and
does
not
exceed
HED's
levels
of
concern.
Combined
incidental
oral
exposures
for
toddlers
result
in
a
MOE
of
390
and
do
not
exceed
HED's
levels
of
concern.
As
stated,
at
1
lb
ai/
A
risk
estimates
for
dermal
exposures
result
in
a
MOE
of
610
and
therefore
at
1
lb
ai/
A,
combined
dermal
and
incidental
oral
exposures
for
toddlers
(
1/[
1/
610
+
1/
390])
result
in
a
MOE
of
240
for
toddlers'
aggregate
dermal
and
oral
exposures,
a
highly
conservative
risk
estimate,
which
is
slightly
lower
than
300.

The
seventh
paragraph
on
homeowner
use
of
atrazine
4L
in
garden
corn
should
be
removed/
deleted
as
the
newest
labels
do
not
contain
this
use.

A
single
label
for
atrazine
4L
(
EPA
Reg.
No.
829­
268)
permits
professional
application
to
"
corn
in
the
home
garden."
As
this
was
the
only
such
label
use
found,
the
potential
postapplication
risk
to
residents
was
not
quantitatively
assessed;
but
as
the
potential
risk
estimated
for
postapplication
workers
was
low,
the
residential
risk
is
also
considered
low.
Atrazine
is
usually
applied
when
corn
is
12"
tall.

Tables
10
and
11
summarize
these
results.

Table
10
should
now
read:
20
Table
10.
Residential
Short­
term
Dermal
Postapplication
Risks
for
Atrazine
(
Using
TTR
values
from
liquid
and
granular
Atrazine
turf
studies
­
MRID
Nos.
449580­
01,
449588­
01)

Dermal
Scenarios
Exposure
Time
(
hours/
day
)
Short
Term
Risks
Transfer
Coefficienta
(
cm2
/
hr)
MOEs
c
GA
granular
GA/
NC
liquid
(
Avg.)
FL
granular
Non­
irrig.
Irrig.
Non­
irrig.
Irrig.

Adult
dermal
turf
contact
2
14,500
4300
3400
510
(
2
lb
ai/
A)
1000
(
1
lb
ai/
A)
1200
21,000
Child
dermal
turf
contact
2
5,200
2600
2000
310
(
2
lb
ai/
A)
610
(
1
lb
ai/
A)
690
13,000
Adult
walking,
playing
golf
4
500
62,000
49,000
7400
(
2
lb
ai/
A)
14,800
(
1
lb
ai/
A)
17,000
310,000
Adult
push
mowing
lawn
2
500
120,000
98,000
15,000
(
2
lb
ai/
A)
30,000
(
1
lb
ai/
A)
34,000
620,000
a
Transfer
coefficient
from
revisions
to
Residential
SOP'
s
(
02/
01).

b
TTR
source:
liquid
and
granular
turf
studies
MRID
#
449580­
01,
449588­
01,
DAT
0­
1
residue
(
see
Table
9).
The
average
DAT
0
residue
was
used
and
calculated
from
2
sites
across
2
time
points
for
each
site
(
0
and
0.5
days
).
All
formulations
in
the
studies
were
applied
at
a
rate
of
2
lb
ai/
acre.
c
MOE
=
Short­
term
NOAEL
(
104
mg/
kg/
day)
/
dermal
dose
where
dermal
dose
=
TTR
(
µ
g/
cm2
)
x
TC
(
cm2
/
hr)

x
conversion
factor
(
1
mg/
1,000
µ
g)
x
exposure
time
(
2
hrs/
day)
/
body
weight
(
70
kg
adult
or
15
kg
1­
to
6­
year­
old).

Notes:
TTR
=
Turf
Transferable
Residue.
Short­
term
NOAEL
of
104
mg/
kg/
day
reflects
6%
dermal
absorption
factor
applied
to
6.25
mg/
kg/
day
short­
term
oral
endpoint.

Table
11
should
read
as
follows:
21
Table
11.
Residential
Short­
term
Oral
Nondietary
Postapplication
Risks
to
Children
(
1­
6)
from
"
Hand­
to­
Mouth"
and
Ingestion
Ex
posure
When
Reentering
Lawns
Treated
with
Granular
or
Liquid
Atrazine
Formulations
Type
of
Exposure
Applicati
on
Ratea
(
lb
ai/
acre)
Ingestion
Rate
or
Other
Assumptionsb
Oral
Dosec
(
mg/
kg/
day)
MOEd
Hand
to
Mouth
Activity
liquid
2
Residential
SOPs
0.030
0.015
(
1
lb
ai/
A)
210
420
granular
Atrazine
Granular
Hand­
Press
Study
0.0066
950
Turfgrass/
Object
Mouthing
2
liquid
or
granular
Residential
SOPs
0.0019
3300
1
liquid
Residential
SOPs
9.5
x
10­
4
6600
Ingestion
of
Soil
2
liquid
or
granular
Residential
SOPs
1.0E­
4
62,500
1
liquid
Residential
SOPs
5
x
10­
5
130,000
Total
of
the
Oral
Exposures
Abovee
Liquid
formulation
0.032
(
2
lb
ai/
A)
0.016
(
1
lb
ai/
A)
200
390
Granular
formulation
0.0086
730
Incidental
Ingestion
of
Granules
0.42%
ai
0.2­
0.4
g/
day
(
100­
200
lbs
formulation
/
acre)
0.056­
0.11
57­
110
1.5%
ai
0.2­
0.4
16­
31
Table
11.
Residential
Short­
term
Oral
Nondietary
Postapplication
Risks
to
Children
(
1­
6)
from
"
Hand­
to­
Mouth"
and
Ingestion
Ex
posure
When
Reentering
Lawns
Treated
with
Granular
or
Liquid
Atrazine
Formulations
Type
of
Exposure
Applicati
on
Ratea
(
lb
ai/
acre)
Ingestion
Rate
or
Other
Assumptionsb
Oral
Dosec
(
mg/
kg/
day)
MOEd
22
Footnotes:

a
Application
rates
represent
maximum
label
rates
from
current
EPA
registered
labels
of
2
lb
ai/
A.
b
Assumptions
from
Draft
Residential
SOP'
s
(
1997,
revised
2/
01).

c
Oral
doses
calculated
using
formulas
presented
in
the
Residential
SOPs
(
December,
1999).
Shortterm
doses
were
calculated
using
the
following
formulas.
Hand­
to­
mouth;
in
the
absence
of
DFR
data,
Revised
Residential
SOPs
(
02/
01)
are
used:
oral
dose
to
child
(
1­
6
year
old)
on
the
day
of
treatment
(
mg/
kg/
day)
=
[
application
rate
(
lb
ai/
acre)
x
fraction
of
residue
dislodgeable
with
potentially
wet
hands
(
5%)
x
11.2
(
conversion
factor
to
convert
lb
ai/
acre
to
µ
g/
cm2)]
x
median
surface
area
for
1­
3
fingers
(
20
cm2/
event)
x
hand­
to­
mouth
rate
(
ST:
20
events/
hour)
x
50%
saliva
extraction
factor
x
exp.
time
(
2
hr/
day)
x
0.001
mg/:
g]
/
bw
(
15
kg
child
).
For
granular
formulations,
the
atrazine
granular
hand­
press
study
data
(
MRIDs
45622310,
45622311)
were
used:
the
average
moistened
hand­
mouth
granular
residue
transfer
rate
of
1.1%
of
the
ai
application
rate.
Grass/
object
mouthing;
oral
dose
to
child
(
1­
6
year
old)
on
the
day
of
treatment
(
mg/
kg/
day)
=
[
application
rate
(
lb
ai/
acre
x
11.2
(
conversion
factor
to
convert
lb
ai/
acre
to
µ
g/
cm2))
x
fraction
of
residue
dislodgeable
(
5%)
x
ingestion
rate
of
grass
(
25
cm2/
day)
x
.001
mg/:
g]
/
bw
(
15
kg
child
).
Soil
ingestion;
oral
dose
to
child
(
1­
6
year
old)
on
the
day
of
treatment
(
mg/
kg/
day)
=
[(
application
rate
(
lb
ai/
acre)
x
fraction
of
residue
retained
on
uppermost
1
cm
of
soil
(
100%
or
1.0/
cm)
x
4.54E+
08
µ
g/
lb
conversion
factor
x
2.47E­
08
acre/
cm2
conversion
factor
x
0.67
cm3/
g
soil
conversion
factor)
x
100
mg/
day
ingestion
rate
x
1.0E­
06
g/
µ
g
conversion
factor]
/
bw
(
15
kg).
Short
term
dose
based
residue
on
the
soil
on
day
of
application.
Granular
pellet
ingestion:
(
mg/
kg/
day)
oral
dose
to
child
(
1­
6
year
old)
=
[
Granule
ingestion
rate
(
0.2­
0.4
g/
day)
x
Fraction
of
ai
of
granule
formulations
x
1,000
mg/
g]
/
bw
(
15
kg).
d
Oral
MOE
=
Oral
NOAEL
(
6.25
mg/
kg/
day
for
short­
term
assessments)
/
Oral
Dose
(
mg/
kg/
day).
Oral
NOAEL
determined
from
a
rat
study.
MOEs
are
reported
to
two
significant
figures;
target
MOE
is
at
least
300.
e
Combined
MOE
may
be
obtained
by
dividing
oral
NOAEL
by
sum
of
oral
doses,
or
by
taking
the
inverse
of
the
sum
of
the
inverses
of
the
MOEs:
Combined
MOE
=
1/[
1/
MOE1
+
1/
MOE2
etc.]
23
Section
5.0
­
Aggregate
Risk
Assessments
and
Risk
Characterization
Section
5.3.2
­
Short­
Term
Aggregate
Risk
Estimates
for
Toddlers'
Post­
Application
Exposures
This
section
should
now
read:

Liquid
Formulations
Aggregate
risk
estimates
for
liquid
formulations
applied
at
2
lb
ai/
A
for
short­
term
hand­
tomouth
exposures
result
in
a
MOE
of
210
and
exceed
HED's
level
of
concern.
HED
estimates
that
toddlers'
exposures
from
individual
and
aggregated
pathways
for
incidental
oral
exposures
exceed
HED's
levels
of
concern
with
a
MOE
of
200
based
on
combined
exposures
from
hand­
tomouth
transfer
of
residues,
grass
and
soil
ingestion
activities
by
toddlers
on
grass.
Dermal
exposures
for
toddlers'
result
in
a
MOE
of
310
on
grass.
Toddlers'
short­
term
individual
and
aggregate
incidental
exposures
each
have
MOEs
less
than
300
for
liquid
formulations.
Any
addition
(
or
aggregation)
of
combined
exposures
through
the
dermal,
dietary
(
food
and
drinking
water)
or
incidental
oral
pathways
would
result
in
risk
estimates
that
further
exceed
HED's
level
of
concern
for
toddlers.
Consequently,
the
short­
term
DWLOC
is
zero
for
aggregated
exposures
from
liquid
formulations
at
2
lb
ai/
A
across
multiple
exposure
routes
for
toddlers,
indicating
risks
exceeding
HED's
level
of
concern.
See
Table
13a.

If
the
liquid
formulation
application
rates
are
reduced
to
1
lb
ai/
A,
the
resulting
MOE
for
toddlers'
hand­
to­
mouth
exposures
is
420,
and
does
not
exceed
HED's
levels
of
concern.
Combined
incidental
oral
exposure
for
toddlers
result
in
a
MOE
of
390
and
does
not
exceed
HED's
levels
of
concern.
At
1
lb
ai/
A
risk
estimates
for
dermal
exposures
result
in
a
MOE
of
610.
At
1
lb
ai/
A,
combined
dermal
and
incidental
oral
exposures
for
toddlers
(
1/[
1/
610
+
1/
390])
result
in
a
MOE
of
240
for
toddlers'
aggregate
dermal
and
oral
exposures,
a
highly
conservative
risk
estimate,
which
is
slightly
lower
than
300.
Consequently,
at
a
reduced
rate
of
1
lb
ai/
A,
the
short­
term
DWLOC
is
zero
for
aggregated
exposures
from
liquid
formulations
across
multiple
exposure
routes
for
toddlers,
indicating
risks
exceeding
HED's
level
of
concern.
HED
has
identified
one
CWS
where
short­
term
drinking
water
exposures
combined
with
short­
term
residential
exposures
result
in
short­
term
aggregate
risk
estimates
exceed
HED's
level
of
concern.
However,
because
of
the
conservative
nature
of
the
aggregate
risk
estimates
for
residential
exposures
and
the
limited
use
pattern
for
atrazine
turf
products,
i.
e.,
the
Southeast,
the
coincidence
of
high­
end
home
lawn
use
exposures
with
high­
end
drinking
water
exposures
are
anticipated
to
be
limited.

Granular
Formulations
Toddlers'
risk
estimates
from
individual
or
aggregated
(
combined)
pathways
for
incidental
oral
24
exposures
based
on
granular
formulations
do
not
exceed
HED's
levels
of
concern;
i.
e.,
a
MOE
of
730.
Toddlers'
risk
estimates
from
dermal
exposures
based
on
granular
formulations
also
do
not
exceed
HED's
levels
of
concern;
i.
e.,
MOEs
of
690
(
for
applications
that
are
not
watered­
in
immediately
after
application
and
2000
for
applications
that
are
watered­
in
immediately
after
application).
Combined
dermal
and
incidental
oral
exposures
result
in
a
MOE
of
350
or
greater
and
do
not
exceed
HED's
level
of
concern
[
1/(
1/
690
+
1/
730)
=
350].
Short­
term
DWLOCs
for
toddlers'
post
application
aggregate
exposures
do
not
exceed
HED's
level
of
concern
for
granular
formulations
watered­
in
after
application
to
turf.
Short­
term
DWLOCs
for
toddlers'
post
application
aggregate
exposures
exceed
HED's
level
of
concern
for
granular
formulations
that
are
not
watered­
in
after
application
to
turf.
HED
recommends
changes
to
granular
products
requiring
homeowners
to
water­
in
applications
to
turf.
See
table
13a.

Exposure
to
atrazine
through
ingestion
of
granules
by
toddlers
result
in
MOEs
of
16
to
110.
Granule
ingestion
by
toddlers
is
considered
an
episodic
event
(
a
stand
alone
incident)
and
has
not
been
aggregated
with
either
other
incidental
oral
exposures
or
dermal
and
dietary
exposures.

Table
13a.
Aggregate
DWLOC
Based
on
High­
end
Residential
Post
application
Short­
Term
Exposures
for
Toddlers
on
Turf
Grass
Treated
with
Liquid
and
Granular
Formulations
of
Atrazine
Type
of
Exposure
Formulation/
Application
Rate
(
lbs
ai/
acre)
Dietary
Dose*
(
mg/
kg/
day
)
Absorbed
Dermal
Dose
(
mg/
kg/
day)
Dermal
MOE
(
mg/
kg/
day)
Aggregate
Incidental
Oral
Dose
(
mg/
kg/
day
)
Aggregate
Incidental
Oral
MOE
ST
DWLOC
(
ppb)

Dermal
Contact
on
Turf
2
lb
ai/
acre
(
liquid)
0.000017
0.02
310
0.032
200
zero
Dermal
Contact
on
Turf
1
lb
ai/
acre
(
liquid)
0.000017
0.01
610
0.014
390
zero
Dermal
Contact
on
Turf
2
lb
ai/
acre
(
granular)
without
watering­
in
0.000017
0.009
690
0.0086
730
12
­
14*

Dermal
Contact
on
Turf
2
lb
ai/
acre
(
granular)
with
watering­
in
0.000017
0.003
2000
0.0086
730
35
­
39*

*
Depending
on
toddler
body
weight
assumed
either
13
or
15
kg.

In
the
Midwest,
based
on
available
data,
weekly
concentrations
of
atrazine
and
the
chlorotriazine
metabolites
have
been
measured
in
drinking
water
up
to
89
ppb.
Available
drinking
water
25
monitoring
data
for
CWS
for
which
30­
day
average
concentrations
can
be
estimated
indicate
concentrations
up
to
60
ppb.
However,
these
high­
end,
short­
term
concentrations
do
not
cooccur
with
residential
uses
of
atrazine.
In
the
South,
residential
use
of
atrazine
and
high­
end
drinking
water
exposures
may
be
expected
to
co­
occur.
Monthly
average
concentrations
of
atrazine
and
the
chlorotriazine
metabolites
range
up
to
30
ppb
in
the
CWS
at
Iberville
in
LA
.
Therefore,
residential
use
and
high­
end
drinking
water
exposures
coincide
at
Iberville
in
LA.
However,
since
the
highest
average
short­
term
concentrations
of
chlorotriazines
(
30
ppb
at
Iberville)
in
drinking
water
co­
occurring
with
residential
uses
is
less
than
the
lowest
short­
term
DWLOC
(
35­
39
ppb),
short­
term
aggregate
risk
estimates
based
on
granular
formulations
that
have
been
watered­
in
after
application
do
not
exceed
HED's
level
of
concern
for
children.

Section
5.3.3
­
Short­
Term
Aggregate
Risk
Estimates
for
Adults'
Post­
Application
Exposures
This
section
should
now
read:

Table
13b
summarizes
the
results
of
HED's
aggregate
risk
assessment
for
short­
term
exposures
of
adults
playing
on
atrazine­
treated
lawns
immediately
after
application.
These
estimates
of
risk
combine
dermal
and
oral
(
dietary)
exposures
because
short­
term
dermal
and
dietary
exposures
have
a
common
toxic
effect,
delayed
puberty
as
a
biomarker
for
neuroendocrine
effects.

Table
13b.
Aggregate
DWLOCs
Based
on
High­
end
Residential
Post
application
Short­
Term
Exposures
for
Adults
on
Treated
Turf
Grass
Type
of
Exposure
Formulation/
Applicati
on
Rate
(
lbs
ai/
acre)
Dietary
Dose*
(
mg/
kg/
day)
Dermal
Dose
(
mg/
kg/
day)
Absorbed
Dermal
Dose
(
mg/
kg/
day)
Dermal
MOE
(
mg/
kg/
day
)
ST
DWLOC*
(
ppb)

Dermal
Contact
2
lb
ai/
acre
(
liquid)
0.000003
0.20
0.012
520
130
2
lb
ai/
acre
(
granular)
0.000003
0.09
0.0054
1200
157
Dermal
Contact
Walking/
Pla
ying
Golf
2
lb
ai/
acre
(
liquid)
0.000003
0.014
0.0008
7800
210
2
lb
ai/
acre
(
granular)
0.000003
0.0062
0.0004
16,000
215
Dermal
Contact
Pushing
lawn
Mower
2
lb
ai/
acre
(
liquid)
0.000003
0.007
0.0004
16,000
214
2
lb
ai/
acre
(
granular)
0.000003
0.003
0.00018
35,000
217
26
Table
13b
shows
short­
term
DWLOC
values
for
adults
for
exposure
scenarios
for
high
contact
activities
(
gardening/
playing),
golfing,
and
mowing
lawns.
Based
on
the
available
data,
monthly
average
chlorotriazine
concentrations
in
drinking
water
have
been
measured
up
to
30
ppb
in
the
South.
Since
short­
term
DWLOCs
are
greater
than
measured
short­
term
concentrations
of
chlorotriazines
in
CWS
where
drinking
water
and
residential
exposures
may
co­
occur,
risk
estimates
for
adults'
short­
term
aggregate
exposures
do
not
exceed
HED's
level
of
concern.
Short­
term
DWLOC
values
for
adult
post
application
exposures
are
based
on
an
average
body
weight
of
70
kg.

Section
7.0
­
Occupational
Risk
Assessments
Table
14
should
be
replaced
with
the
table
below.
This
table
is
Table
8
in
the
document,
"
Atrazine:
Revised
Occupational
and
Residential
Exposure
Assessment
and
Recommendations
for
the
Reregistration
Eligibility
Decision",
August
30,
2002.
Please
see
this
document
for
details.
27
Table
14:
Summary
of
Occupational
Short­
term
and
Intermediate­
term
Combined
Dermal
+
Inhalation
Handler
Risks
from
Atrazine
(
Using
PHED,
ORETF,
and
Combined
PHED/
Handler
Study
Data)

Exposure
Scenario
Crop
Type
Applicati
on
Rate
(
lb
ai
or
lb
ai/
gallon
&
lbs
fertilizer)

(
a)
Area
Treated
per
Day
(
Acres
or
Gallons)

(
b)
Baseline
MOE(
c)
PPE
(
Gloves,

Coveralls,

Respirator)
MOE
(
d)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:
PHED
+
Handler
Study
Data
(
f)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:

PHED
+
Handler
Study
Data
(
f)

Shortterm
(
g)
Interme
diateterm
(
h)
Shortterm
(
g)
Interme
diateterm
(
h)
Short­
term
(
g)
Intermediate­
term
(
h)

Mixer/
Loader
Mixing/
Loading
Liquid
Formulations
for
Aerial
Application
(
1a)
conifer
forests,
sugarcane,

conifer
(
Christmas
tree)
farms,

sod
farms
in
FL
4
350
2
0.4
248
61
520
430
130
110
sugarcane
3
350
3
0.7
381
94
800
660
200
160
chemical
fallow
3
1,200
1
NA
96
NA
200
170
NA
NA
3
350
2
0.6
330
82
690
570
170
140
1.4
1,200
1
NA
206
NA
430
360
NA
NA
1
350
5
1.3
708
170
1,500
1,200
370
300
CRP/
grassla
nds
2
1,200
1
NA
144
NA
300
250
NA
NA
2
350
4
0.9
495
120
1,000
850
260
210
corn,
sorghum
2
1,200
1
NA
144
NA
300
250
NA
NA
350
4
0.9
495
120
1,000
850
260
210
1
1,200
2
NA
289
NA
610
500
NA
NA
1
350
7
2
991
240
2,100
1,700
520
420
sod
farms
2
350
4
1
495
120
1,000
850
260
210
Table
14:
Summary
of
Occupational
Short­
term
and
Intermediate­
term
Combined
Dermal
+
Inhalation
Handler
Risks
from
Atrazine
(
Using
PHED,
ORETF,
and
Combined
PHED/
Handler
Study
Data)

Exposure
Scenario
Crop
Type
Applicati
on
Rate
(
lb
ai
or
lb
ai/
gallon
&
lbs
fertilizer)

(
a)
Area
Treated
per
Day
(
Acres
or
Gallons)

(
b)
Baseline
MOE(
c)
PPE
(
Gloves,

Coveralls,

Respirator)
MOE
(
d)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:
PHED
+
Handler
Study
Data
(
f)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:

PHED
+
Handler
Study
Data
(
f)

Shortterm
(
g)
Interme
diateterm
(
h)
Shortterm
(
g)
Interme
diateterm
(
h)
Short­
term
(
g)
Intermediate­
term
(
h)

28
Mixing/
Loading
Liquid
Formulations
for
Groundboom
Application
(
1b)
sugar
cane,

macadamia
nuts,
guava,

conifers,
sod
farms
in
FL
4
80
8
2
1,084
270
2,300
1,900
560
460
sugarcane
3
80
12
3
1,667
410
3,500
2,900
870
710
chemical
fallow
3
450
2
NA
257
NA
540
440
NA
NA
3
200
4
1
578
140
1,200
1,000
300
250
1.4
450
4
NA
550
NA
1,200
950
NA
NA
1
200
9
2
1,238
310
2,600
2,100
640
530
CRP/
grassla
nds
2
450
3
NA
385
NA
810
660
NA
NA
2
200
6
2
867
210
1,800
1,500
450
370
corn,
sorghum
2
450
3
NA
385
NA
810
660
NA
NA
2
200
6
2
867
210
1,800
1,500
450
370
1
450
6
NA
771
NA
1,600
1,300
NA
NA
1
200
12
3
1,734
430
3,600
3,000
900
740
roadsides
1
40
62
15
8,669
2,100
18,000
15,000
4,500
3,700
golf
course
turf,
roadsides
2
40
31
8
4,335
1,100
9,100
7,500
2,300
1,800
sod
farms
2
80
16
4
2,167
540
4,600
3,700
1,100
920
Mixing/
Loading
Liquid
Formulations
for
Rights­
of­
Way
Sprayer
(
1c)
roadsides
1
40
62
15
8,669
2,100
18,000
15,000
4,500
3,700
Table
14:
Summary
of
Occupational
Short­
term
and
Intermediate­
term
Combined
Dermal
+
Inhalation
Handler
Risks
from
Atrazine
(
Using
PHED,
ORETF,
and
Combined
PHED/
Handler
Study
Data)

Exposure
Scenario
Crop
Type
Applicati
on
Rate
(
lb
ai
or
lb
ai/
gallon
&
lbs
fertilizer)

(
a)
Area
Treated
per
Day
(
Acres
or
Gallons)

(
b)
Baseline
MOE(
c)
PPE
(
Gloves,

Coveralls,

Respirator)
MOE
(
d)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:
PHED
+
Handler
Study
Data
(
f)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:

PHED
+
Handler
Study
Data
(
f)

Shortterm
(
g)
Interme
diateterm
(
h)
Shortterm
(
g)
Interme
diateterm
(
h)
Short­
term
(
g)
Intermediate­
term
(
h)

29
bermuda
grass
rights
of
way
2
40
31
8
4,335
1,100
9,100
7,500
2,300
1,800
Mixing/
Loading
Liquid
Formulations
for
Lawn
Handgun
Application
(
LCO)
(
1d)
lawns,
golf
courses
2
100
12
3
1,734
430
3,600
3,000
900
740
Mixing/
Loading
/
Incorporating
Liquid
Formulations
onto
Liquid
or
Dry
Bulk
Fertilizer
(
1e)
commercial
fertilizer
for
corn,
sorghum:

*
PHED
data
2
960
tons
See
Engineering
Controls
64
NA
500
tons
See
Engineering
Controls
120
36
*
Helix
study
data
500
tons
See
Engineering
Controls
170
67
commercial
fertilizer
for
corn,
sorghum:

*
PHED
data
1
960
tons
See
Engineering
Controls
120
NA
500
tons
See
Engineering
Controls
230
72
*
Helix
Study
data
500
tons
See
Engineering
Controls
350
130
Table
14:
Summary
of
Occupational
Short­
term
and
Intermediate­
term
Combined
Dermal
+
Inhalation
Handler
Risks
from
Atrazine
(
Using
PHED,
ORETF,
and
Combined
PHED/
Handler
Study
Data)

Exposure
Scenario
Crop
Type
Applicati
on
Rate
(
lb
ai
or
lb
ai/
gallon
&
lbs
fertilizer)

(
a)
Area
Treated
per
Day
(
Acres
or
Gallons)

(
b)
Baseline
MOE(
c)
PPE
(
Gloves,

Coveralls,

Respirator)
MOE
(
d)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:
PHED
+
Handler
Study
Data
(
f)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:

PHED
+
Handler
Study
Data
(
f)

Shortterm
(
g)
Interme
diateterm
(
h)
Shortterm
(
g)
Interme
diateterm
(
h)
Short­
term
(
g)
Intermediate­
term
(
h)

30
on­
farm
fertilizer
for
corn,
sorghum
2
160
8
NA
700
NA
1,900
NA
NA
NA
1
160
15
NA
1,400
NA
3,800
NA
NA
NA
Mixing/
Loading
Dry
Flowable
(
Water
Dispersible
Granule)
for
Aerial
(
2a)
conifer
forests,
sugarcane,

conifer
(
Christmas
tree)
farms,

turf
for
sod
in
FL
4
350
66
16
105
26
380
130
sugarcane
3
350
100
25
161
40
580
140
chemical
fallow
3
1,200
26
NA
41
NA
150
NA
3
350
88
22
140
35
500
120
chemical
fallow
1.4
1,200
55
NA
87
NA
320
NA
1
350
190
47
300
74
1,100
270
CRP/
grassla
nds
2
1,200
38
NA
61
NA
220
NA
2
350
130
33
210
52
750
190
corn,
sorghum
2
1,200
38
NA
61
NA
220
NA
2
350
130
33
210
52
750
190
1
1,200
77
NA
122
NA
440
NA
1
350
260
65
420
100
1,500
370
sod
farms
2
350
130
33
210
52
750
190
Table
14:
Summary
of
Occupational
Short­
term
and
Intermediate­
term
Combined
Dermal
+
Inhalation
Handler
Risks
from
Atrazine
(
Using
PHED,
ORETF,
and
Combined
PHED/
Handler
Study
Data)

Exposure
Scenario
Crop
Type
Applicati
on
Rate
(
lb
ai
or
lb
ai/
gallon
&
lbs
fertilizer)

(
a)
Area
Treated
per
Day
(
Acres
or
Gallons)

(
b)
Baseline
MOE(
c)
PPE
(
Gloves,

Coveralls,

Respirator)
MOE
(
d)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:
PHED
+
Handler
Study
Data
(
f)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:

PHED
+
Handler
Study
Data
(
f)

Shortterm
(
g)
Interme
diateterm
(
h)
Shortterm
(
g)
Interme
diateterm
(
h)
Short­
term
(
g)
Intermediate­
term
(
h)

31
Mixing/
Loading
Dry
Flowables
(
water
dispersible)
for
Groundboom
Application
(
2b)
sugar
cane,

macadamia
nuts,
guava,

conifers,
sod
farms
in
FL
4
80
290
71
459
110
1,600
410
sugarcane
3
80
440
110
706
170
2,500
630
chemical
fallow
3
450
68
NA
109
NA
400
NA
3
200
150
38
245
61
880
220
1.4
450
150
NA
233
NA
840
NA
1
200
330
82
525
130
1,900
470
CRP/
grassla
nds
2
450
100
NA
163
NA
580
NA
2
200
230
57
367
91
1,300
330
corn,
sorghum
2
450
100
NA
163
NA
580
NA
2
200
230
57
367
91
1,300
330
1
450
210
NA
326
NA
1,200
NA
1
200
460
110
734
180
2,600
650
roadsides
1
40
2,300
570
3,672
910
13,000
3,300
2
40
1,200
290
1,836
450
6,600
1,600
golf
course
turf
2
40
1,200
290
1,836
450
6,600
1,600
sod
farms
2
80
580
140
918
230
3,300
820
Table
14:
Summary
of
Occupational
Short­
term
and
Intermediate­
term
Combined
Dermal
+
Inhalation
Handler
Risks
from
Atrazine
(
Using
PHED,
ORETF,
and
Combined
PHED/
Handler
Study
Data)

Exposure
Scenario
Crop
Type
Applicati
on
Rate
(
lb
ai
or
lb
ai/
gallon
&
lbs
fertilizer)

(
a)
Area
Treated
per
Day
(
Acres
or
Gallons)

(
b)
Baseline
MOE(
c)
PPE
(
Gloves,

Coveralls,

Respirator)
MOE
(
d)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:
PHED
+
Handler
Study
Data
(
f)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:

PHED
+
Handler
Study
Data
(
f)

Shortterm
(
g)
Interme
diateterm
(
h)
Shortterm
(
g)
Interme
diateterm
(
h)
Short­
term
(
g)
Intermediate­
term
(
h)

32
Mixing/
Loading
Dry
Flowables
(
water
dispersible)
for
Rights
of
Way
(
2c)
roadsides
1
40
2,300
570
3,672
910
13,000
3,300
2
40
1,200
290
1,836
450
6,600
820
Loading
Granular
Formulations
(
3)
sod
farms
2
80
1,200
310
5,023
1,200
62,000
15,000
golf
course
turf
2
40
2,500
610
10,047
2,500
120,000
31,000
Applicator
Spraying
Liquids
with
Aircraft
(
4)
conifer
forests,
sugarcane,

conifer
(
Christmas
tree)
farms,

sod
farms
in
FL
4
350
See
Engineering
Controls
See
Engineering
Controls
850
210
sugarcane
3
350
1,300
320
chemical
fallow
3
1,200
330
NA
3
350
1,100
280
1.4
1,200
710
NA
1
350
2,400
600
CRP/
grassla
nds
2
1,200
500
NA
2
350
1,700
420
Table
14:
Summary
of
Occupational
Short­
term
and
Intermediate­
term
Combined
Dermal
+
Inhalation
Handler
Risks
from
Atrazine
(
Using
PHED,
ORETF,
and
Combined
PHED/
Handler
Study
Data)

Exposure
Scenario
Crop
Type
Applicati
on
Rate
(
lb
ai
or
lb
ai/
gallon
&
lbs
fertilizer)

(
a)
Area
Treated
per
Day
(
Acres
or
Gallons)

(
b)
Baseline
MOE(
c)
PPE
(
Gloves,

Coveralls,

Respirator)
MOE
(
d)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:
PHED
+
Handler
Study
Data
(
f)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:

PHED
+
Handler
Study
Data
(
f)

Shortterm
(
g)
Interme
diateterm
(
h)
Shortterm
(
g)
Interme
diateterm
(
h)
Short­
term
(
g)
Intermediate­
term
(
h)

33
corn,
sorghum
2
1,200
See
Engineering
Controls
See
Engineering
Controls
500
NA
2
350
1,700
420
1
1,200
990
NA
1
350
3,400
840
sod
farms
2
350
1,700
420
Groundboom
Application
(
5)
sugar
cane,

macadamia
nuts,
guava,

conifers,
sod
farms
in
FL
4
80
860
210
1,690
420
4,000
2,700
980
620
sugarcane
3
80
1,300
330
2,600
640
6,100
4,100
1,500
950
chemical
fallow
3
450
200
51
401
99
940
640
NA
NA
3
200
460
110
901
220
2,100
1,400
520
330
1.4
450
440
110
858
210
2,000
1,400
NA
NA
1.4
200
990
240
1,931
480
4,500
3,100
1,100
710
CRP/
grassla
nds
2
450
310
76
601
150
1,400
950
NA
NA
2
200
690
170
1,352
330
3,200
2,100
790
500
corn,
sorghum
2
450
310
76
601
150
1,400
950
NA
NA
2
200
690
170
1,352
330
3,200
2,100
790
500
corn,
sorghum
1
450
610
150
1,202
300
2,800
1,900
NA
NA
1
200
1,400
340
2,704
670
6,400
4,300
1,600
990
roadsides
2
40
3,500
850
6,759
1,700
16,000
10,000
3,900
2,500
1
40
6,900
1,700
13,519
3,300
32,000
20,000
7,900
5,000
golf
course
turf
2
40
3,500
850
6,759
1,700
16,000
10,000
3,900
2,500
Table
14:
Summary
of
Occupational
Short­
term
and
Intermediate­
term
Combined
Dermal
+
Inhalation
Handler
Risks
from
Atrazine
(
Using
PHED,
ORETF,
and
Combined
PHED/
Handler
Study
Data)

Exposure
Scenario
Crop
Type
Applicati
on
Rate
(
lb
ai
or
lb
ai/
gallon
&
lbs
fertilizer)

(
a)
Area
Treated
per
Day
(
Acres
or
Gallons)

(
b)
Baseline
MOE(
c)
PPE
(
Gloves,

Coveralls,

Respirator)
MOE
(
d)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:
PHED
+
Handler
Study
Data
(
f)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:

PHED
+
Handler
Study
Data
(
f)

Shortterm
(
g)
Interme
diateterm
(
h)
Shortterm
(
g)
Interme
diateterm
(
h)
Short­
term
(
g)
Intermediate­
term
(
h)

34
sod
farms,

conifer
(
Christmas
tree)
farms
2
80
1,700
430
3,380
840
8,000
5,000
2,000
1,200
Rights­
of­
Way
Sprayer
(
6)
roadsides
2
40
67
16
300
74
ND
ND
ND
ND
roadsides
1
40
130
33
601
150
ND
ND
ND
ND
Applying
Liquids
with
a
Handgun
(
7)

(
ORETF)
lawns,
golf
courses
2
5
ND
ND
980
(
G)
240
(
G)
NF
NF
Applying
Impregnated
Dry
Bulk
Granular
Fertilizer
with
Tractor
Drawn
Spreader(
8)
corn,
sorghum
2
320
190
NA
660
NA
1,000
NA
NA
NA
160
380
NA
1,300
NA
1,900
NA
NA
1
320
380
NA
1,300
NA
1,900
NA
NA
160
900
NA
2,600
NA
4,000
NA
NA
Applying
Granular
with
a
Tractor
Drawn
Spreader
(
9)
corn,
sorghum
2
200
610
150
2,221
550
3,200
790
2
80
1,500
380
5,553
1,400
7,900
2000
1
200
1,200
300
4,442
1,100
6,400
1600
1
80
3,000
750
11,100
2,700
16,000
4000
golf
course
turf
2
40
3,000
750
11,100
2,700
16,000
4000
Mixer/
Loader/
Applicator
Table
14:
Summary
of
Occupational
Short­
term
and
Intermediate­
term
Combined
Dermal
+
Inhalation
Handler
Risks
from
Atrazine
(
Using
PHED,
ORETF,
and
Combined
PHED/
Handler
Study
Data)

Exposure
Scenario
Crop
Type
Applicati
on
Rate
(
lb
ai
or
lb
ai/
gallon
&
lbs
fertilizer)

(
a)
Area
Treated
per
Day
(
Acres
or
Gallons)

(
b)
Baseline
MOE(
c)
PPE
(
Gloves,

Coveralls,

Respirator)
MOE
(
d)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:
PHED
+
Handler
Study
Data
(
f)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:

PHED
+
Handler
Study
Data
(
f)

Shortterm
(
g)
Interme
diateterm
(
h)
Shortterm
(
g)
Interme
diateterm
(
h)
Short­
term
(
g)
Intermediate­
term
(
h)

35
Backpack
Sprayer
(
LCO)

(
10)
lawns,
golf
courses
2
5
ND
ND
428
110
Not
Feasible
Low
Pressure
Handwand
­

Liquid
Formulations
(
LCO)
(
11)
lawns,
golf
courses
2
5
7
2
1549
380
Not
Feasible
Lawn
Handgun
(
LCO)
[
ORETF]

(
12a)
Liquid
lawns,
golf
courses
2
5
ND
ND
1400
(
G)
340
(
G)
Not
Feasible
(
12b)
WDG
ND
ND
1100
(
G)
290
(
G)

(
12c)
WSP
ND
ND
920
(
G)
230
(
G)

Granulars
with
a
Push
Type
Spreader
(
LCO)

[
ORETF]
(
13)
lawns,
golf
courses
2
5
1500
380
2100
(
G)
520
(
G)
Not
Feasible
Granulars
with
a
Bellygrinder
(
LCO)
(
14)
lawns,
golf
courses
2
1
330
82
616
150
Not
Feasible
Flagging
Table
14:
Summary
of
Occupational
Short­
term
and
Intermediate­
term
Combined
Dermal
+
Inhalation
Handler
Risks
from
Atrazine
(
Using
PHED,
ORETF,
and
Combined
PHED/
Handler
Study
Data)

Exposure
Scenario
Crop
Type
Applicati
on
Rate
(
lb
ai
or
lb
ai/
gallon
&
lbs
fertilizer)

(
a)
Area
Treated
per
Day
(
Acres
or
Gallons)

(
b)
Baseline
MOE(
c)
PPE
(
Gloves,

Coveralls,

Respirator)
MOE
(
d)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:
PHED
+
Handler
Study
Data
(
f)
Engineering
Controls
MOE:
PHED
Data
(
e)
Engineering
Controls
MOE:

PHED
+
Handler
Study
Data
(
f)

Shortterm
(
g)
Interme
diateterm
(
h)
Shortterm
(
g)
Interme
diateterm
(
h)
Short­
term
(
g)
Intermediate­
term
(
h)

36
Flagging
Sprays
(
15)
conifer
forests,
sugarcane,

conifer
(
Christmas
tree)
farms,

sod
farms
4
350
310
76
466
120
910
NA
220
NA
sugarcane
3
350
480
120
717
180
1,400
350
chemical
fallow
3
350
410
100
621
150
1,200
300
chemical
fallow
1.4
350
880
220
1,331
330
2,600
640
CRP/
grassla
nds
2
350
620
150
931
230
1,800
450
corn,
sorghum
2
350
620
150
931
230
1,800
450
corn,
sorghum
1
350
1,200
310
1,863
460
3,600
900
sod
farms
2
350
620
150
931
230
1,800
450
Footnotes:

a
Application
rates
represent
maximum
rates
determined
from
EPA
registered
labels
for
atrazine.
Typical
use
rates
as
determined
by
BEAD
were
assessed
for
corn
and
sorghum
(
1.0
lb
ai/
acre),
sugarcane
(
2.6
lb
ai/
acre)
and
chemical
fallow
(
1.4
lb
ai/
acre).

For
commercial
bulk
fertilizer
admixture:
If
two
pounds
atrazine
active
ingredient
per
acre
is
impregnated
onto
400
pounds
of
fertilizer
(
for
the
400
37
pounds
fertilizer
per
acre
rate),
each
ton
(
2000
pounds)
of
fertilizer
would
require
10
pounds
of
atrazine
active
ingredient.
Thus,
the
total
amount
of
active
ingredient
for
960
tons
for
the
two
pound
active
ingredient
per
400
pounds
of
fertilizer
per
acre
rate
is
(
960)(
10)
=
9600
pounds
of
atrazine
active
ingredient
handled
per
day.
Using
the
registrant­
supplied
upper
limit
of
production,
only
500
tons
are
produced,
so
(
500)(
10)
=
5000
pounds
of
atrazine
handled
per
day.
PHED
data
used
for
closed
system
liquid
admixture.
Arithmetic
mean
of
operator
exposure
data
from
Helix
(
TM)
Canadian
seed
treatment
study
submitted
by
Syngenta.

Estimated
Application:
320
A/
day
estimated
for
20­
ton
commercial
truck
spreader;
160
A/
day
reasonable
max
for
10­
ton
truck
or
on­
farm
equipment.

b
Acres
treated
per
day
based
on
Exposure
SAC
Policy
#
9
"
Standard
Values
for
Daily
Acres
Treated
In
Agriculture,"
Revised
June
23,
2000.
Also
high
acreage
estimated
from
submitted
study
data
75th
percentile
for
corn
=
450
acres/
day.
Some
high
and
typical
acreage
used
to
characterize
short
and
intermediate
term
exposure.

c
Baseline
MOEs:
see
Occupational
Short­
term
and
Intermediate­
term
Handler
Risks
from
Atrazine
at
Baseline
Table.

d
PPE
MOEs:
see
Occupational
Short­
term
and
Intermediate­
term
Handler
Risks
from
Atrazine
with
PPE
Risk
Mitigation
Table.

e
Engineering
Control
MOEs:
see
Occupational
Short­
term
and
Intermediate­
term
Handler
Risks
from
Atrazine
with
Engineering
Controls
Table.

f
Engineering
control
dermal
unit
exposure
values
taken
from
submitted
by
Novartis
Crop
Protection
Inc.,
passive
dosimetry
data
combined
with
PHED
corresponding
scenario
data
MRID
443154­
04.

g
Short­
term
dermal
MOE
=
NOAEL
(
104
mg/
kg/
day)
/
daily
dose
(
mg/
kg/
day).

Dermal
daily
dose
(
mg/
kg/
day)
=
daily
unit
exposure
(
mg/
lb
ai)
x
application
rate
(
lb
ai/
acre)
x
amount
handled
per
day
(
acres/
day)
/
body
weight
(
70
kg
adult
for
short­
term
and
60
kg
adult
female
­­
for
developmental
effects
­­
for
intermediate­
term
assessment).
For
intermediate­
term
dermal
dose
an
absorption
factor
of
6
percent
applies.

Short­
term
inhalation
MOE
=
NOAEL
(
6.25
mg/
kg/
day)
/
daily
dose
(
mg/
kg/
day).

Inhalation
daily
dose
(
mg/
kg/
day)
=
inhalation
unit
exposure
(
µ
g/
lb
ai)
x
application
rate
(
lb
ai/
acre)
x
amount
handled
per
day
(
acres/
day)
x
conversion
factor
(
1
mg/
1,000
µ
g)
/
body
weight
(
70
kg
adult
for
short
term
and
60
kg
developmental
female
for
intermediate­
term
assessment).

h
Intermediate­
term
dermal
and
inhalation
MOE
=
NOAEL
(
1.8
mg/
kg/
day
based
on
an
oral
developmental
study)
/
daily
dose
(
mg/
kg/
day).

CRP
=
Conservation
Reserve
P
rogram
UNK
=
Unknown
­­
additional
use
information
needed
NA
=
Not
applicable
to
the
specified
scenario
and/
or
duration
of
exposure
NN
=
Not
needed
­­
MOE
>
100
at
previous
risk
mitigation
level
NF
=
Not
feasible
­­
no
engineering
control
known
for
this
application
method