Document ID: EPA-HQ-OPP-2008-0271-0007
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2009-07-14T04:00Z

MEMORANDUM

DATE:  	May 13, 2009

SUBJECT:	Indoxacarb: Refined Chronic Aggregate Dietary (Food and
Drinking Water) Exposure and Risk Assessment for the Section 3
Registration Action. 

PC Code: 067710	DP Barcode:   D364939

Decision No.: 355154	Registration No.: 352-597

Petition No.: 8E7324	Regulatory Action: Section3

Risk Assessment Type: Single Chemical /Aggregate	Case No.: NA

TXR No.: NA	CAS No.: 173584-44-6

MRID No.: NA	40 CFR:180.564

REVIEWER:	Seyed Tadayon, Chemist

Reregistration Branch III

Health Effects Division (7509P)

THROUGH: 	Danette Drew, Chemist

Reregistration Branch V

Health Effects Division (7509P)

TO:	Danette Drew, Chemist

Reregistration Branch V

Health Effects Division (7509P)

Purpose				

	This is a refinement of the original Acute and Chronic Aggregate
Dietary (Food and

Drinking Water) Exposure and Risk Assessment for the Section 3
Registration Action Document

For Indoxacarb (D360559, S.Tadayon, February 18, 2009).  

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Refined chronic dietary risk assessments were conducted using the
Dietary Exposure Evaluation Model - Food Consumption Intake Database
(DEEM-FCID(, ver. 2.03).  DEEM- FCID( incorporates the food consumption
data from the United States Department of Agriculture’s (USDA’s
Continuing Surveys of Food Intakes by Individuals (CSFII; 1994-1996 and
1998).  The chronic analyses incorporated field trial residues for all
commodities (except grape and milk).

Field trial data were used for apple, apricot, broccoli, cabbage,
cantaloupe, celery, cherry, corn, cotton seed oil, cranberry, cucumber,
lettuce, mint, mustard, peach, peanut, pear, pepper, plumes, southern
pea, spinach and tomatoes. The 2005 PDP data was used for grape  and
2007 PDP data for heavy cream was used for milk.  PDP data for heavy
cream showed a non-detectable residue.  The refined chronic analyses
incorporated average percent crop treated information provided by the
Biological Economic Analysis Division (BEAD; 02-April-2007) and
available PDP data.  The analyses also included the chronic surface
water point estimate generated using the PRZM and EXAMS and the turf
application scenario (2 x 0.22 lb ai/acre; 7-day retreatment interval
(RTI); highest registered/proposed rate).  The chronic exposure
estimates are (4.4% cPAD and are, therefore, not of concern to HED.  
The most highly-exposed population subgroup was children 1 to 2 years
old.  

Summary of chronic dietary exposure and risk for indoxacarb is presented
in table 1.

Table 1:	Summary of Chronic Dietary Exposure and Risk for Indoxacarb
(Drinking Water Exposure Included).

Population Subgroup	cPAD (mg/kg/day)	Chronic

Exposure (mg/kg/day)	

%cPAD

General U.S. Population	0.02	0.000516	2.6

All Infants (< 1 year old)

0.000579	2.9

Children 1-2 years old

0.000880	4.4

Children 3-5 years old

0.000843	4.2

Children 6-12 years old

0.000485	2.4

Youth 13-19 years old

0.000435	2.2

Adults 20-49 years old

0.000419	2.1

Adults 50+ years old

0.000621	3.1

Females 13-49 years old

0.000432	2.2

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