Document ID: EPA-HQ-OPP-2007-0303-0005
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2008-04-09T04:00Z

UNITED STAES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C.  20460

OFFICE OF

 PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM

DATE:		December 5, 2007  

SUBJECT:	Fenhexamid.  Chronic Dietary Exposure Assessment for the
Interregional Research Project No. 4 (IR-4) Petition Proposing
Tolerances for Residues of Fenhexamid on Asparagus (PP# 7E7187).

PC Code:		090209   	

Decision Number:  	375841

DP Number:		347171

REVIEWER:	Breann Hanson, Biologist 

Alternative Risk Integration and Assessment (ARIA) Team

Risk Integration Minor Use and Emergency Response Branch 			
(RIMUERB)/Registration Division (RD) (7505P)

THROUGH:	William Cutchin, Chemist 

		ARIA Team

RIMERB/RD (7505P)

AND

Toiya Goodlow, Chemist

		Dietary Exposure Science Advisory Council (DESAC)

		Health Effects Division (7509P)

TO:		Breann Hanson, Biologist

ARIA Team

RIMUERB/RD (7505P)

Executive Summary

The purpose of this memorandum is to report the results of a dietary
(food + drinking water) exposure analysis for an IR-4 petition (PP#
7E7187) for the fungicide fenhexamid for use on asparagus.  The petition
is to be evaluated in a forthcoming risk assessment.  Chronic dietary
risk assessments were conducted using the Dietary Exposure Evaluation
Model (DEEM-FCID™, Version 2.03) which uses food consumption data from
the U.S. Department of Agriculture’s Continuing Surveys of Food
Intakes by Individuals (CSFII) from 1994-1996 and 1998.  

No toxic effects attributable to a single (i.e., acute) exposure to
fenhexamid have been identified; therefore, an acute reference dose
(RfD) has not been established for fenhexamid and an acute dietary
exposure assessment has not been conducted.  Fenhexamid has been
classified as a “not likely” human carcinogen.  Therefore, a cancer
dietary risk assessment is not required. 

Chronic Dietary (Food + Drinking Water) Exposure Results and
Characterization

A chronic dietary assessment assuming tolerance-level residues for all
commodities with existing and proposed tolerances, 100% crop treated
(CT) and DEEM™ 7.81 default processing factors (PFs) was conducted for
the general population and all population subgroups.  The only
exceptions to these assumptions was a 0.5x EPA processing adjustment
factor for grapes destined for wine and sherry production and a 4.3x
factor for currants, dried (grape, raisin PF), previously established
for use in dietary assessments by HED.  The mean (i.e., relevant to
chronic exposure) drinking water estimate of 1.1 ppb, provided by the
Environmental Fate and Effects Division (EFED), was directly
incorporated into the chronic assessment.  The chronic dietary risk
assessment shows that for all included commodities, the chronic dietary
risk estimates are below ARIA’s level of concern (i.e. <100% chronic
population adjusted doses (cPAD)).  For the U.S. population the exposure
for food and water utilized 10% of the cPAD.  The chronic dietary risk
estimate for the highest reported exposed population subgroup, children
1-2 years old, is 27% of the cPAD.

I.	Introduction

Dietary risk assessment incorporates both exposure and toxicity of a
given pesticide.  For acute and chronic assessments, the risk is
expressed as a percentage of a maximum acceptable dose.  This is the
population adjusted dose (PAD), which HED has concluded will result in
no unreasonable adverse health effects.  The PAD is equivalent to point
of departure (POD; e.g., NOAEL, LOAEL) divided by the required
uncertainty or safety factors.  Dietary risk is expressed as a
percentage of the PAD.

For acute and non-cancer chronic exposures, HED is concerned when
estimated dietary risk exceeds 100% of the PAD.  HED is generally
concerned when estimated cancer risk exceeds one in one million. 
References which discuss the acute and chronic risk assessments in more
detail are available on the EPA/pesticides web site:  “Available
Information on Assessing Exposure from Pesticides, A User’s Guide”,
21/06/2000, web link: 
http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see
SOP 99.6 (8/20/1999).

The most recent dietary risk assessment for fenhexamid was conducted by
W. Carr from the California Department of Pesticide Regulation and
approved by C. Swartz from HED (DP#: 328660, 5/22/2006) for its use on
cliantro (transplant/greenhouse), non-bell pepper (transplant) and
pomegranate (post-harvest).

 II.	Residue Information

Fenhexamid Use:

In this analysis the chronic dietary exposure and risk estimates
resulting from food intake were determined for the general U.S.
population and various population subgroups resulting from the addition
of asparagus to the existing food uses for fenhexamid.

Permanent tolerances for residues of fenhexamid
[N-(2,3-dichloro-4-hydroxyphenyl)-1-methyl-cyclohexanecarboxamide] are
listed in 40 CFR §180.553 ranging from 0.02 ppm in/on almond, pepper,
non-bell and pistachio to 30 ppm in/on cilantro, leaves and leafy
greens, subgroup 4A, except spinach. 

Residue Data Used for Chronic Assessment:

The chronic assessment was based on the assumption of tolerance-level
residues for all existing commodities and the proposed asparagus
tolerance.  For all commodities 100% CT was used.  For most commodities
DEEM™ 7.81 default PFs were used; the only exceptions to this
assumption were a 0.5x EPA processing adjustment factor for grapes
destined for wine and sherry production and a 4.3x factor for currants,
dried (grapes, raisin PF).  These processing adjustment factors were
previously established for use in dietary assessments by HED.  The
recommended tolerance for asparagus was provided by ARIA (DP#: 346385,
D. Rate, 11/30/2007).  As part of the current petition, ARIA recommends
establishing a permanent tolerance of 0.02 ppm for residues of
fenhexamid in asparagus.

Table 1.   Tolerance Summary for Fenhexamid                        

Commodity	Recommended Tolerance (ppm)

Asparagus	0.02

III.	Drinking Water Data

The drinking water residues used in the dietary risk assessment were
provided by EFED and summarized in the following memoranda: “Drinking
Water Assessment for the IR-4 Petition for the Use of Fenhexamid on
Asparagus” (DP#: 338651,C. Sutton, 7/26/2007) and incorporated
directly into this dietary assessment.  Water residues were incorporated
in the DEEM-FCID into the food categories “water, direct, all
sources” and “water, indirect, all sources.” 

Estimated drinking water concentrations (EDWCs) for fenhexamid in
surface water and groundwater were calculated using the screening model
FQPA Index Reservoir Screening Tool (FIRST; v.1.1.0; dated 12/12/2005)
and the regression model Screening Concentration in Ground Water
(SCI-GROW; v.2.3; dated 7/29/2003), respectively.  The maximum
application rate for the proposed use on asparagus does not exceed the
previous maximum application rate for any crop.  Thus, the values
reported in the previous drinking water assessment (DP#: D285210,
5/13/2003), are still current and are recommended for use in HED’s
risk assessment for fenhexamid.  The drinking water estimate of 1.1 ppb
from surface water sources was directly incorporated into the chronic
dietary assessment.  Ground water sources were not included, as the
EDWCs for this water source are minimal in comparison to surface water.

Table 2.  Maximum Tier 1 EDWCs of Fenhexamid in Groundwater and Surface
Water Based on Fenhexamid Use at the Maximum Total Application Rate.  

Drinking Water Source (Model Used)	Use/Rate Modeled 

(lb ai/A)	Maximum EDWC (ppb)

Groundwater

(SCI-GROW2)	Ground spray/0.75 x 2 applications; total of 3.0 	Acute and
Chronic	0.0007

Surface Water (FIRST)	Ground spray/0.75 x 2 applications; total of 3.0
Acute	29

	Ground spray/0.75 x 2 applications; total of 3.0	Chronic	1.1

.	DEEM-FCID™ Program and Consumption Information

A fenhexamid chronic dietary exposure assessment were conducted using
the Dietary Exposure Evaluation Model software with the Food Commodity
Intake Database (DEEM-FCID™, Version 2.03), which incorporates
consumption data from USDA’s Continuing Surveys of Food Intakes by
Individuals (CSFII), 1994-1996 and 1998.  The 1994-96, 98 data are based
on the reported consumption of more than 20,000 individuals over two
non-consecutive survey days.  Foods “as consumed” (e.g., apple pie)
are linked to EPA-defined food commodities (e.g. apples, peeled fruit -
cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S,
baked) using publicly available recipe translation files developed
jointly by USDA/ARS and EPA.  For chronic exposure assessment,
consumption data are averaged for the entire U.S. population and within
population subgroups, but for acute exposure assessment are retained as
individual consumption events.  Based on analysis of the 1994-96, 98
CSFII consumption data, which took into account dietary patterns and
survey respondents, HED concluded that it is most appropriate to report
risk for the following population subgroups: the general U.S.
population, all infants (<1 year old), children 1-2, children 3-5,
children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+
years old.

For chronic dietary exposure assessment, an estimate of the residue
level in each food or food-form (e.g., orange or orange juice) on the
food commodity residue list is multiplied by the average daily
consumption estimate for that food/food form to produce a residue intake
estimate.  The resulting residue intake estimate for each food/food form
is summed with the residue intake estimates for all other food/food
forms on the commodity residue list to arrive at the total average
estimated exposure.  Exposure is expressed in mg/kg body weight/day and
as a percent of the cPAD.  This procedure is performed for each
population subgroup.

V.	Toxicological Information

The HED Hazard Identification Assessment Review Committee (HIARC)
reassessed FQPA requirements in response to questions posed by the
Natural Resources Defense Council (NRDC).  No new data have been
reviewed and no changes were made to the toxicology endpoints previously
selected for fenhexamid (with the exception of the FQPA safety factor
applied).  

The HIARC concluded that there is low concern for pre- and/or postnatal
toxicity resulting from exposure to fenhexamid.   The HIARC determined
that no special FQPA safety factor is needed (i.e. 1X) since there are
no residual uncertainties for pre and/or post natal toxicity.  In
addition the HIARC concluded that there is not a concern for
developmental neurotoxicity resulting from exposure to fenhexamid.

The HIARC committee determined that an acute dietary exposure assessment
was not necessary.  HIARC also classified fenhexamid as a “not
likely” human carcinogen.  This classification is based on the lack of
evidence of carcinogenicity in male and female rats as well as in male
and female mice and on the lack of genotoxicity in an acceptable battery
of mutagenicity studies.  

The chronic PAD (cPAD) is 0.17 mg/kg/day.  While there is no longer a
standing HIARC committee, no new toxicology endpoints data have been
presented and reviewed for fenhexamid and the previously selected
endpoints and uncertainty factors are considered relevant for the
current assessment.  

Table 3.  Summary of Toxicological Endpoints for Use in Human Health
Risk Assessment1

Exposure

Scenario	Dose Used in Risk Assessment,

UF	FQPA SF and Endpoint  for Risk Assessment	Study and Toxicological
Effects

Acute Dietary

(general population including infants and children)	

None selected.  No appropriate toxicological endpoint attributable to a
single exposure was identified in the available toxicology studies.

Chronic Dietary

all populations	

NOAEL =

 17 mg/kg/day

UF = 100

Chronic RfD = 0.17 mg/kg/day	

FPQA SF= 1X

cPAD = chronic RfD

                 FQPA SF 

               = 0.17 mg/kg/day	

 ADVANCE \d4 1-Year Feeding-Dog. 

Decreased RBC count, hemoglobin and hematocrit and increased Heinz
bodies in males and females; increased adrenal weights and
intracytoplasmic vacuoles in adrenal cortex in females. at the LOAEL of
124 mg/kg/day.

Cancer

(oral, dermal, inhalation)	Fenhexamid is classified as “Not Likely
Human Carcinogen”.		

1 UF = uncertainty factor; NOAEL = no observed adverse effect level;
LOAEL = lowest observed adverse effect level; PAD = population adjusted
dose (a = acute, c = chronic); RfD = reference dose; FQPA SF = Food
Quality Protection Act Safety Factor.

VI.	Results/Discussion 

 is concerned when dietary risk exceeds 100% of the PAD.  The
DEEM-FCID™ analyses estimate the dietary exposure of the U.S.
population and various population subgroups.  The results reported in
Table 4 are for the general U.S. Population, all infants (<1 year old),
children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49,
adults 20-49, and adults 50+ years.  

Results of Chronic Dietary Exposure Analysis

The chronic dietary exposure for food and surface water utilized 10% of
the cPAD for the U.S. population.  The chronic dietary exposure for the
highest reported exposed population subgroup, children 1-2 years old,
was 27% of the cPAD.

The results of the acute and chronic dietary exposure analyses are
reported in the Summary Table (Table 4, below).  

Table 4.  Summary of Dietary Exposure Risk for Fenhexamid

Population Subgroup	Chronic Dietary

	Dietary Exposure

(mg/kg/day)	% cPAD*

General U.S. Population	0.017657	10

All Infants (< 1 year old)	0.030064	18

Children 1-2 years old	0.045219	27

Children 3-5 years old	0.034218	20

Children 6-12 years old	0.021757	13

Youth 13-19 years old	0.014096	8.3

Adults 20-49 years old	0.014908	8.8

Adults 50+ years old	0.015058	8.9

Females 13-49 years old	0.015358	9.0

* % PADs are reported to 2 significant figures.

* *The values for the highest exposed population for each type of risk
assessment are bolded.

This analysis is a highly conservative dietary exposure assessment. 
Further refinement to the analysis could be made through the use of
anticipated residues, incorporation of percentages of crops treated with
fenhexamid, and/or monitoring data that better reflect residues at the
time of consumption.  Since risk estimates are below ARIA’s level of
concern, a more highly refined analysis is not needed at this time.

VII.	Conclusions

A chronic dietary (food and drinking water) exposure assessment was
conducted for the proposed and existing uses of fenhexamid.  

  

The chronic dietary exposure to fenhexamid is below ARIA’s level of
concern for the general U.S. population and all population subgroups. 
The chronic dietary exposure utilized 10% of the cPAD for the general
U.S. population and 27% of the cPAD for children 1-2 years old, the most
highly exposed population subgroup. 

VIII.	List of Attachments

Attachment 1:  Chronic Food plus Water Residue Input File

Attachment 2:  Chronic Results File

cc:

Sidney Jackson

Attachment 1:  Chronic Food plus Water Residue Input File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for FENHEXAMID                        
1994-98 data

Residue file: C:\Documents and Settings\bhanson\My Documents\Breann's
Work\ARIA\Fenhexamid\Asparagus\Finals\090209c.R98

                                                           Adjust. #2
NOT used

Analysis Date 11-20-2007             Residue file dated:
11-20-2007/16:22:53/8

Reference dose (RfD) = 0.17 mg/kg bw/day

Comment:PP#7E7167

------------------------------------------------------------------------
--------

Food Crop                                       Residue      
Adj.Factors      Comment

EPA Code  Grp  Food Name                          (ppm)       

                                                             #1        
#2 

14000030 14   Almond                             0.020000   1.000     
1.000   

14000031 14   Almond-babyfood                    0.020000   1.000     
1.000   

14000040 14   Almond, oil                        0.020000   1.000     
1.000   

14000041 14   Almond, oil-babyfood               0.020000   1.000     
1.000   

04010050 4A   Amaranth, leafy                   30.000000   1.000     
1.000   

12000120 12   Apricot                           10.000000   1.000     
1.000   

12000121 12   Apricot-babyfood                  10.000000   1.000     
1.000   

12000130 12   Apricot, dried                    10.000000   6.000     
1.000   

12000140 12   Apricot, juice                    10.000000   1.000     
1.000   

12000141 12   Apricot, juice-babyfood           10.000000   1.000     
1.000   

04010180 4A   Arugula                           30.000000   1.000     
1.000   

95000190 O    Asparagus                          0.020000   1.000     
1.000   Propos

  Full comment: Proposed '07 Tol (PP#7E7167)

13010550 13A  Blackberry                        20.000000   1.000     
1.000   

13010560 13A  Blackberry, juice                 20.000000   1.000     
1.000   

13010561 13A  Blackberry, juice-babyfood        20.000000   1.000     
1.000   

13020570 13B  Blueberry                          5.000000   1.000     
1.000   

13020571 13B  Blueberry-babyfood                 5.000000   1.000     
1.000   

13010580 13A  Boysenberry                       20.000000   1.000     
1.000   

12000900 12   Cherry                            10.000000   1.000     
1.000   

12000901 12   Cherry-babyfood                   10.000000   1.000     
1.000   

12000910 12   Cherry, juice                     10.000000   1.500     
1.000   

12000911 12   Cherry, juice-babyfood            10.000000   1.500     
1.000   

04011040 4A   Chrysanthemum, garland            30.000000   1.000     
1.000   

19011180 19A  Coriander, leaves                 30.000000   1.000     
1.000   

19011181 19A  Coriander, leaves-babyfood        30.000000   1.000     
1.000   

04011330 4A   Cress, garden                     30.000000   1.000     
1.000   

04011340 4A   Cress, upland                     30.000000   1.000     
1.000   

09021350 9B   Cucumber                           2.000000   1.000     
1.000   

13021360 13B  Currant                            5.000000   1.000     
1.000   

13021370 13B  Currant, dried                     5.000000   4.300     
1.000   Raisin

  Full comment: Raisin AF1 used

04011380 4A   Dandelion, leaves                 30.000000   1.000     
1.000   

13011420 13A  Dewberry                          20.000000   1.000     
1.000   

08001480 8    Eggplant                           2.000000   1.000     
1.000   

13021490 13B  Elderberry                         5.000000   1.000     
1.000   

04011500 4A   Endive                            30.000000   1.000     
1.000   

01011680 1AB  Ginseng, dried                     0.300000   1.000     
1.000   

13021740 13B  Gooseberry                         5.000000   1.000     
1.000   

95001750 O    Grape                              4.000000   1.000     
1.000   

95001760 O    Grape, juice                       4.000000   1.200     
1.000   

95001761 O    Grape, juice-babyfood              4.000000   1.200     
1.000   

95001770 O    Grape, leaves                      4.000000   1.000     
1.000   

95001780 O    Grape, raisin                      6.000000   4.300     
1.000   

95001790 O    Grape, wine and sherry             4.000000   0.500     
1.000   EPA pr

  Full comment: EPA processing factor

13021910 13B  Huckleberry                        5.000000   1.000     
1.000   

95001950 O    Kiwifruit                         15.000000   1.000     
1.000   

04012040 4A   Lettuce, head                     30.000000   1.000     
1.000   

04012050 4A   Lettuce, leaf                     30.000000   1.000     
1.000   

13012080 13A  Loganberry                        20.000000   1.000     
1.000   

12002300 12   Nectarine                         10.000000   1.000     
1.000   

08002340 8    Okra                               2.000000   1.000     
1.000   

04012480 4A   Parsley, leaves                   30.000000   1.000     
1.000   

12002600 12   Peach                             10.000000   1.000     
1.000   

12002601 12   Peach-babyfood                    10.000000   1.000     
1.000   

12002610 12   Peach, dried                      10.000000   7.000     
1.000   

12002611 12   Peach, dried-babyfood             10.000000   7.000     
1.000   

12002620 12   Peach, juice                      10.000000   1.000     
1.000   

12002621 12   Peach, juice-babyfood             10.000000   1.000     
1.000   

11002660 11   Pear                              10.000000   1.000     
1.000   

11002661 11   Pear-babyfood                     10.000000   1.000     
1.000   

11002670 11   Pear, dried                       10.000000   6.250     
1.000   

11002680 11   Pear, juice                       10.000000   1.000     
1.000   

11002681 11   Pear, juice-babyfood              10.000000   1.000     
1.000   

08002700 8    Pepper, bell                       2.000000   1.000     
1.000   

08002701 8    Pepper, bell-babyfood              2.000000   1.000     
1.000   

08002710 8    Pepper, bell, dried                2.000000   1.000     
1.000   

08002711 8    Pepper, bell, dried-babyfood       2.000000   1.000     
1.000   

08002720 8    Pepper, nonbell                    0.020000   1.000     
1.000   

08002721 8    Pepper, nonbell-babyfood           0.020000   1.000     
1.000   

08002730 8    Pepper, nonbell, dried             0.020000   1.000     
1.000   

14002820 14   Pistachio                          0.020000   1.000     
1.000   

12002850 12   Plum                              10.000000   1.000     
1.000   

12002851 12   Plum-babyfood                     10.000000   1.000     
1.000   

12002860 12   Plum, prune, fresh                 1.500000   1.000     
1.000   

12002861 12   Plum, prune, fresh-babyfood        1.500000   1.000     
1.000   

12002870 12   Plum, prune, dried                 2.500000   5.000     
1.000   

12002871 12   Plum, prune, dried-babyfood        2.500000   5.000     
1.000   

12002880 12   Plum, prune, juice                10.000000   1.400     
1.000   

12002881 12   Plum, prune, juice-babyfood       10.000000   1.400     
1.000   

95002890 O    Pomegranate                        2.000000   1.000     
1.000   

04013130 4A   Radicchio                         30.000000   1.000     
1.000   

13013200 13A  Raspberry                         20.000000   1.000     
1.000   

13013201 13A  Raspberry-babyfood                20.000000   1.000     
1.000   

13013210 13A  Raspberry, juice                  20.000000   1.000     
1.000   

13013211 13A  Raspberry, juice-babyfood         20.000000   1.000     
1.000   

95003590 O    Strawberry                         3.000000   1.000     
1.000   

95003591 O    Strawberry-babyfood                3.000000   1.000     
1.000   

95003600 O    Strawberry, juice                  3.000000   1.000     
1.000   

95003601 O    Strawberry, juice-babyfood         3.000000   1.000     
1.000   

08003740 8    Tomatillo                          2.000000   1.000     
1.000   

08003750 8    Tomato                             2.000000   1.000     
1.000   

08003751 8    Tomato-babyfood                    2.000000   1.000     
1.000   

08003760 8    Tomato, paste                      2.000000   5.400     
1.000   

08003761 8    Tomato, paste-babyfood             2.000000   5.400     
1.000   

08003770 8    Tomato, puree                      2.000000   3.300     
1.000   

08003771 8    Tomato, puree-babyfood             2.000000   3.300     
1.000   

08003780 8    Tomato, dried                      2.000000  14.300     
1.000   

08003781 8    Tomato, dried-babyfood             2.000000  14.300     
1.000   

08003790 8    Tomato, juice                      2.000000   1.500     
1.000   

86010000 O    Water, direct, all sources         0.001100   1.000     
1.000   

86020000 O    Water, indirect, all sources       0.001100   1.000     
1.000   

Attachment 2:  Chronic Results File

U.S. Environmental Protection Agency                                
Ver. 2.00

DEEM-FCID Chronic analysis for FENHEXAMID                       (1994-98
data)

Residue file name: C:\Documents and Settings\bhanson\My
Documents\Breann's Work\ARIA\Fenhexamid\Asparagus\Finals\090209c.R98

                                                 Adjustment factor #2
NOT used.

Analysis Date 11-20-2007/16:23:46     Residue file dated:
11-20-2007/16:22:53/8

Reference dose (RfD, Chronic) = .17 mg/kg bw/day

COMMENT 1: PP#7E7167

========================================================================
=======

                    Total exposure by population subgroup

------------------------------------------------------------------------
-------

                                                    Total Exposure

                                        
-----------------------------------

          Population                         mg/kg             Percent
of   

           Subgroup                       body wt/day             Rfd   
   

--------------------------------------   -------------      
---------------

U.S. Population (total)                     0.017657               
10.4%

U.S. Population (spring season)             0.017740               
10.4%

U.S. Population (summer season)             0.018861               
11.1%

U.S. Population (autumn season)             0.016854                
9.9%

U.S. Population (winter season)             0.017175               
10.1%

Northeast region                            0.018326               
10.8%

Midwest region                              0.018312               
10.8%

Southern region                             0.015527                
9.1%

Western region                              0.019731               
11.6%

Hispanics                                   0.017711               
10.4%

Non-hispanic whites                         0.018360               
10.8%

Non-hispanic blacks                         0.013379                
7.9%

Non-hisp/non-white/non-black                0.018161               
10.7%

All infants (< 1 year)                      0.030064               
17.7%

Nursing infants                             0.017411               
10.2%

Non-nursing infants                         0.034867               
20.5%

Children 1-6  yrs                           0.036653             
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Females 13-50 yrs                           0.015892                
9.3%

Females 13+ (preg/not nursing)              0.015771                
9.3%

Females 13+ (nursing)                       0.017677               
10.4%

Males 13-19 yrs                             0.013629                
8.0%

Males 20+ yrs                               0.014221                
8.4%

Seniors 55+                                 0.015023                
8.8%

Children 1-2 yrs                            0.045219               
26.6%

Children 3-5 yrs                            0.034218               
20.1%

Children 6-12 yrs                           0.021757               
12.8%

Youth 13-19 yrs                             0.014096                
8.3%

Adults 20-49 yrs                            0.014908                
8.8%

Adults 50+ yrs                              0.015058                
8.9%

Females 13-49 yrs                           0.015358                
9.0%

Fenhexamid	Dietary Exposure and Risk Assessment	DP Number: 347171	

PC Code: 090209	

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	Page   PAGE  3  of   NUMPAGES  10