Document ID: EPA-HQ-OPP-2012-0672-0002
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2012-09-26T04:00Z

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      	UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
       		WASHINGTON, D.C. 20460
      
      
      
      
                                  September 6, 2012
                                                                               
                             OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION
MEMORANDUM
	
SUBJECT:	Product Chemistry Scoping Document for the Registration Review of Ferric Phosphate, Monopotassium Phosphate, and Dipotassium Phosphate.  

            Registration Review Case #:  		6072
            PC Code:						034903, 076413, 176407
            CAS Numbers:					100045-86-0, 7778-77-0, 7758-11-4
            Chemical Class:					Biochemical
                                                                  
FROM:		Angela L. Gonzales, Biologist    	
            Biochemical Pesticides Branch
            Biopesticides & Pollution Prevention Division (7511P)

TO:			Leonard Cole, Senior Regulatory Specialist
            Biochemical Pesticides Branch
            Biopesticides & Pollution Prevention Division (7511P) 

ACTION REQUESTED
	
The following scoping document contains the product chemistry assessment for the biopesticides ferric phosphate, monopotassium phosphate and dipotassium phosphate in support of the development of the Registration Review Work Plan.

Executive Summary

The Agency has made the determination that for the purposes of registration review, there is adequate product chemistry information available on ferric phosphate, monopotassium phosphate and dipotassium phosphate. While the information on file is adequate for registration review, for future pesticide applications, more data and/or information for certain data requirements for these chemicals should be submitted. The data requirements that should be further addressed are discussed below for each chemical. 

Introduction

Ferric Phosphate

As a pesticide, ferric phosphate is used as a molluscicide (specifically, slugs and snails) on and around a variety of ornamental and food crops. The active ingredient was first registered in 1997. There are currently two products registered containing the active ingredient, all of which are end-use products (EPs). One product contains ferric phosphate as the only active ingredient and the other product contains the biopesticide in conjunction with a conventional chemical (spinosad). The chemical is not approved for use as an inert ingredient in pesticide formulations at this time.

Monopotassium Phosphate

As a pesticide, monopotassium phosphate is used as a fungicide on a variety of ornamental and food crops. The active ingredient was first registered in 1994. There are currently four products registered containing the active ingredient, all of which are EPs. Two of the products contain the active ingredient in conjunction with a conventional chemical (sulfur), one product contains the active ingredient in conjunction with another biopesticide (mono- and di- potassium salts of phosphorous acid) and the last product contains monopotassium phosphate as the only active ingredient. The chemical is approved for use as an inert ingredient in pesticide formulations for both nonfood and food (40 CFR § 180.910 and 180.920) uses.

Dipotassium Phosphate

As a pesticide, dipotassium phosphate is used as a fungicide on a variety of ornamental and food crops. The active ingredient was first registered in 2002. There is currently one product registered containing the active ingredient; an EP which contains the chemical in conjunction with another biopesticide (mono- and di- potassium salts of phosphorous acid). The chemical is approved for use as an inert ingredient in pesticide formulations for both nonfood and food (40 CFR § 180.920) uses.

Product Chemistry Summary

Ferric Phosphate

Concerning the product chemistry of ferric phosphate, most biochemical pesticide data requirements for the technical grade active ingredient have been satisfied and are summarized in Table 1 and Table 2. While the information on file is adequate for the purposes of registration review, for future pesticide applications, data on the partition coefficient of the chemical must be submitted according to OCSPP Guidelines 830.7550-7570 and more specific data on the stability of the chemical should be submitted according to OCSPP Guideline 830.6313. 

Table 1. Product Identity and Composition for Ferric Phosphate
Common Name
Iron (III) phosphate; ferric phosphate; ferric orthophosphate
Chemical Name, IUPAC
Phosphoric acid, iron 3[+] salt (1:1)
Molecular Weight
150.82
PC Code
034903
CAS Registry Number
10045-86-0
Molecular Formula
FeO4P
Registration Review Case Number
6072
Chemical Structure
                                       
The Agency has conducted a review of the available product chemistry data and information.  These data are summarized below.

Table 2. Biochemical Pesticides Product Chemistry Data Requirements for Ferric Phosphate
                                 Guideline No.
                       Physical and Chemical Properties
                                   Status[1]
                                     Value
                                     MRID
830.1100
Product Identity and Composition
                                       A
Refer to Table 1.
44073401
44732201
830.1200
Description of starting materials, production and formulation process
                                       A
Confidential Business Information (CBI)
44073401
44732201
830.1400
Discussion of formation of impurities
                                       A
CBI
44732201

830.1700
Preliminary analysis
                                       A
CBI
44042701
44131901
46811902
830.1800
Enforcement analytical method
                                       A
CBI
44042701
44131901
44732202
46811902
48741601
830.6302
Color
                                       A
White to buff
44042703
830.6303
Physical state
                                       A
Dry powder
44042703
830.6304
Odor
                                       A
Odorless
44042703
830.6313
Stability to normal and elevated temperatures, metals and metal ions
                                       A
Stable.

More specific data should be provided to support future registrations (refer to OCSPP Guideline 830.6313).
44042703
830.7000
pH
                                      N/A
Not applicable; chemical is not soluble in water.
44042703
830.7050
UV/Visible light absorption

                                      N/A
Data are not necessary to inform the risk assessment.

830.7200
Melting point/melting range
                                      N/D
Does not melt; degrades into ferric oxide at temperatures near 500ºC
44042703
830.7220
Boiling point/boiling range
                                      N/A
Not applicable; chemical is not a liquid at room temperature

830.7300
Density
                                       A
1 g/ml or 60 lb/ft[3] (bulk density)
44042703
830.7520
Particle size, fiber length, and diameter distribution
                                       A
3 microns (per MSDS)
44070601
830.7550
830.7560
830.7570
Partition coefficient (n-Octanol/Water)
                                      N/A
Not applicable; chemical is an organic compound

830.7840
Water solubility 
                                       A
Insoluble in water
44042703
830.7950
Vapor pressure
                                      N/A
Not applicable; chemical is a non-volatile solid
44042703
1 A=Acceptable. N/A=Not Applicable. N/D=Not Determined.

Monopotassium Phosphate

Concerning the product chemistry of monopotassium phosphate, most biochemical pesticide data requirements for the technical grade active ingredient have been satisfied and are summarized in Table 3 and Table 4. While the information on file is adequate for the purposes of registration review, for future pesticide applications, more specific data on the stability of the chemical should be submitted according to OCSPP Guideline 830.6313. 

Table 3. Product Identity and Composition for Monopotassium Phosphate
Common Name
Monopotassium phosphate; phosphoric acid, monopotassium salt; potassium phosphate, monobasic
Chemical Name, IUPAC
Potassium dihydrogen phosphate
Molecular Weight
136.09
PC Code
076413
CAS Registry Number
7778-77-0
Molecular Formula
H2KO4P
Registration Review Case Number
6072
Chemical Structure
                                       

The Agency has conducted a review of the available product chemistry data and information.  These data are summarized below.

Table 4. Biochemical Pesticides Product Chemistry Data Requirements for Monopotassium Phosphate
                                 Guideline No.
                       Physical and Chemical Properties
                                   Status[1]
                                     Value
                                     MRID
830.1100
Product Identity and Composition
                                       A
Refer to Table 3.
44234201
830.1200
Description of starting materials, production and formulation process
                                       A
CBI
44234201
830.1400
Discussion of formation of impurities
                                       A
CBI
44234201
830.1700
Preliminary analysis
                                       A
CBI
44234201
830.1800
Enforcement analytical method
                                       A
CBI

830.6302
Color
                                       A
White
44234201
830.6303
Physical state
                                       A
Crystalline solid
44234201
830.6304
Odor
                                       A
No characteristic odor
44234201
830.6313
Stability to normal and elevated temperatures, metals and metal ions
                                       A
Stable 

More specific data should be provided to support future registrations (refer to OCSPP Guideline 830.6313).
44234201
830.7000
pH
                                       A
4.5 (1% solution)
44234201
830.7050
UV/Visible light absorption

                                      N/A
Data are not necessary to inform the risk assessment.

830.7200
Melting point/melting range
                                       A
253ºC
HSDB[2]
830.7220
Boiling point/boiling range
                                      N/A
Not applicable; chemical is not a solid at room temperature

830.7300
Density
                                       A
1.3 g/cm[3]

2.3 g/cm[3]
44234201

HSDB[2]
830.7520
Particle size, fiber length, and diameter distribution
                                      N/A
Not applicable; chemical is not water insoluble and fibrous with a diameter >= 0.1um

830.7550
830.7560
830.7570
Partition coefficient (n-Octanol/Water)
                                      N/A
Not applicable; data are not required for chemicals that are soluble in water. 

830.7840
Water solubility 
                                       A
Soluble

25g/100ml water
44234201

HSDB[2]
830.7950
Vapor pressure
                                      N/A
Not applicable; chemical is a non-volatile solid

[1]A=Acceptable. N/A=Not Applicable. N/D=Not Determined.
[2]Hazardous Substances Data Bank, 2012.

Dipotassium Phosphate

Concerning the product chemistry of dipotassium phosphate, most biochemical pesticide data requirements for the technical grade active ingredient have been satisfied and are summarized in Table 5 and Table 6. While the information on file is adequate for the purposes of registration review, for future pesticide applications, more specific data on the stability of the chemical should be submitted according to OCSPP Guideline 830.6313 and more specific data on the solubility of the chemical should be submitted according to OCSPP Guideline 830.7840. 

Table 5. Product Identity and Composition for Dipotassium Phosphate
Common Name
Dipotassium phosphate; phosphonic acid, dipotassium salt; potassium phosphate, dibasic
Chemical Name, IUPAC
dipotassium monohydrogen phosphate
Molecular Weight
174.18
PC Code
176407
CAS Registry Number
7758-11-4
Molecular Formula
HK2O4P
Registration Review Case Number
6072
Chemical Structure
                                       

The Agency has conducted a review of the available product chemistry data and information.  These data are summarized below.

Table 6. Biochemical Pesticides Product Chemistry Data Requirements for Dipotassium Phosphate
                                 Guideline No.
                       Physical and Chemical Properties
                                   Status[1]
                                     Value
                                     MRID
830.1100
Product Identity and Composition
                                       A
Refer to Table 1.
44815001
830.1200
Description of starting materials, production and formulation process
                                       A
CBI
44815001
830.1400
Discussion of formation of impurities
                                       A
CBI
44815001
830.1700
Preliminary analysis
                                       A
CBI
44815001
830.1800
Enforcement analytical method
                                       A
CBI
44815004
830.6302
Color
                                       A
White 
Merck Index[2]
830.6303
Physical state
                                       A
Granules/crystals
Merck Index[2]
830.6304
Odor
                                      N/D
No characteristic odor
MSDS[4]
830.6313
Stability to normal and elevated temperatures, metals and metal ions
                                       A
Stable

More specific data should be provided to support future registrations (refer to OCSPP Guideline 830.6313).
MSDS[4]
830.7000
pH
                                       A
8.8 (1% solution)
HSDB[3]
830.7050
UV/Visible light absorption

                                      N/A
Data are not necessary to inform the risk assessment

830.7200
Melting point/melting range
                                       A
340ºC
MSDS[4]
830.7220
Boiling point/boiling range
                                       A
Not applicable; chemical is not a liquid at room temperature

830.7300
Density
                                       A
2.30 g/cm[3]
MSDS[4]
830.7520
Particle size, fiber length, and diameter distribution
                                      N/A
Not applicable; chemical is not water insoluble and fibrous with a diameter >= 0.1um

830.7550
830.7560
830.7570
Partition coefficient (n-Octanol/Water)
                                      N/A
Not applicable; data are not required for chemicals that are soluble in water.

830.7840
Water solubility 
                                       A
Soluble

More specific data should be provided to support future registrations (refer to OCSPP Guideline 830.7840).
MSDS[4]
830.7950
Vapor pressure
                                      N/A
Not applicable; chemical is a non-volatile solid.

[1]A=Acceptable. N/A=Not Applicable. N/D=Not Determined.
[2]The Merck Index, 2012
[3]HSDB, 2012
[4]MSDS, 2012

References

Hazardous Substances Data Bank (HSDB). United States National Library of Medicine, Online. 09/04/12.
      < http://www.toxnet.nlm.nih.gov/cgi-bin/sis/search>

Material Safety Data Sheet (MSDS) for Potassium Phosphate, Dibasic. Sigma-Aldrich. Online. 09/06/12.
	< http://www.sigmaaldrich.com> 

The Merck Index Online. 14[th] Edition. EPA Library Search. 09/05/12.
	< http://library.dialog.com/bluesheets/html/bl0304.html>