Document ID: EPA-HQ-OPP-2005-0497-0041
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2006-08-23T04:00Z

UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
06/
15/
06
MEMORANDUM:

SUBJECT:
Propiconazole
(
122101):
Reregistration
Eligibility
Decision
(
RED)
Document;
Revised
Residue
Chemistry
Considerations
DP
Barcode:
D329394
Reregistration
Case:
3125
FROM:
Yan
Donovan,
Chemist
Reregistration
Branch
4
Health
Effects
Division
(
7509C)

THROUGH:
Susan
V.
Hummel,
Branch
Senior
Scientist
Reregistration
Branch
4
Health
Effects
Division
(
7509C)

TO:
Michael
Goodis/
Christina
Scheltema
Reregistration
Branch
III
Special
Review
&
Reregistration
Division
(
7508W)

Attached
please
find
the
revised
Residue
Chemistry
Chapter
for
the
Propiconazole
RED.
This
document
was
originally
prepared
under
contract
by
Dynamac
Corporation
(
20440
Century
Boulevard,
Suite
100;
Germantown,
MD
20874;
submitted
02/
16/
2000).
The
document
has
been
reviewed
by
the
Health
Effects
Division
(
HED)
to
ensure
that
it
reflects
current
Office
of
Pesticide
Programs
(
OPP)
policies,
and
updated
to
add
new
information
available
since
2000.
The
product
Chemistry
chapter
was
reviewed
separately.
°
HED
has
been
requested
to
reassess
tolerances
for
propiconazole
uses
on
a
variety
of
crops
(
Use
Closure
Memos
from
SRRD,
dated
on
01/
28/
02
and
04/
22/
05).
Syngenta
(
previously
Novartis)
recently
submitted
new
petitions
to
the
Registration
Division
(
RD)
for
its
product
TiltTM
(
EPA
Registration
No.
100­
617).
The
petitions
propose
tolerances
on
alfalfa,
almond,
beans
(
dry),
berry
crop
group,
carrot,
cranberry,
corn,
leafy
petiole,
mint,
onion,
soybean,
etc..).
Section
B
of
the
petition
(
proposed
use
patterns)
includes
revised
use
patterns
on
existing
crops,
such
as
an
increase
in
application
rate
on
barley,
wheat,
oats,
rye,
and
triticale.
The
data
package
for
the
new
uses
and
revisions
to
the
existing
uses
has
not
been
reviewed,
and
are
not
included
in
this
assessment
of
the
existing
uses
for
Reregistration
Eligibility
Decision
(
RED),
due
to
the
fact
that
RD
is
scheduled
to
complete
its
assessment
of
the
revised
labels
after
the
RED
signature
date,
July
2006,
the
data
package
has
yet
to
be
reviewed.
Therefore,
both
the
new
uses
and
revised
use
patterns
will
be
assessed
separately
from
this
RED.
Syngenta
recently
combined
PP#
4F3007,
4G3075,
5F4498,
PP#
9F3740,
5F4424,
5F4591,
into
a
single
petition,
PP#
2F6371.
IR­
4
is
still
supporting
PP#
5E4437
on
mushrooms
and
8E4931
on
mint
(
now
part
of
2F6371).
Below
are
list
of
the
pending
petitions
which
are
not
included
in
this
RED
chapter.

4F3007
Pecans
4G3075
Rice,
wheat
9F3740
Almonds,
tree
nuts
(
now
part
of
2F6371)
5F4424
Dried
beans,
soybeans
(
now
part
of
2F6371)
5F4498
Alfalfa,
sorghum
(
rotational
crops)
5F4591
Berry
crop
group,
carrots,
onions
(
green
&
dry
bulb)
(
now
part
of
2F6371)
6E4788
Celery
7E4860
Cranberries
8E4931
Mint
2F6371
combines
PP#
4F3007,
4G3075,
5F4498,
9F3740,
5F4424,
and
5F4591.
2F6371
strawberries,
sugar
beets,
wheat,
corn,
rice,
sorghum,
carrots,
onions,
berry
group,
dry
beans,
soybeans,
almonds,
tree
nuts.

Propiconazole
is
among
the
group
of
chemicals
which
generates
a
common
metabolite
called
triazole.
A
separate
document
has
addressed
this
issue
(
see
reference,
D284131).
1,2,4­
triazole
and
conjugates
will
not
be
further
discussed
in
this
chemistry
chapter.
Executive
Summary
Propiconazole
[
1­[[
2­(
2,4­
dichlorophenyl)­
4­
propyl­
1,3­
dioxolan­
2­
yl]
methyl]­
1H­
1,2,4­
triazole]
is
a
systemic
broad­
spectrum
fungicide
registered
for
treatment
of
disease
in/
on
a
variety
of
crops.
Propiconazole
end­
use
products
are
marketed
in
the
United
States
under
the
trade
names
Tilt
®
,
Alamo
®
,
Banner
®
,
and
Orbit
®
.
Recently,
propiconazole
is
also
registered
for
use
on
a
variety
of
crops
under
the
trade
names
of
Stratego
 
Twin­
Pak
 
and
Stratego
 
,
which
are
end­
use
products
containing
a
mixture
of
trifloxystrobin
and
propiconazole.
The
amount
of
active
ingredient
range
from
11.4%
to
45%.
The
propiconazole
formulations
registered
for
food/
feed
uses
include
emulsifiable
concentrate
(
EC)
and
flowable
concentrate
(
FlC)
formulations.
Except
for
pineapple
and
sugarcane
(
seed
pieces),
all
uses
are
pre­
harvest
foliar
application,
ground
or
air.
Pineapple
and
sugarcane
uses
are
postharvest
uses.
The
application
rates
range
from
0.081
lbs
ai/
A/
season
(
such
as
wheat)
to
0.90
lbs
ai/
A/
season
(
grass
grown
for
seed).

Available
plant
metabolism
data
(
primary
and
rotated
crops)
show
that
plants
absorb,
metabolize
and
translocate
propiconazole
throughout
the
plant.
A
major
metabolic
pathway
in
plants
appears
to
be
hydroxylation
(
primarily
of
the
beta­
carbon)
of
the
n­
propyl
group
on
the
dioxolane
ring
of
the
cis/
trans
isomers
of
propiconazole.
These
metabolites
appear
to
readily
form
sugar
conjugates.
The
majority
of
TRR
was
found
in
the
stalks,
such
as
peanut
stalk,
wheat
forage
and
straw,
grape
leaves,
and
celery
stalks.
The
HED
MARC
concluded
that
for
plants
and
animals,
residues
of
propiconazole
and
all
its
metabolites
containing
the
2,4­
dichlorophenyl
moiety
(
2,4­
DCBA),
including
conjugates,
are
of
concern
and
should
be
included
in
the
dietary
(
food)
risk
assessments,
propiconazole
per
se
should
be
included
in
the
dietary
(
water)
risk
assessments.
For
tolerance
expression,
MARC
concluded
that
the
current
tolerance
expression
for
propiconazole
should
be
amended
to
include
residues
of
propiconazole
per
se
only.
For
enforcement
purpose,
the
Multiresidue
Methods
Section
302
(
Luke
Method;
Protocol
D)
picks
up
parent
propiconazole.

Tolerances
are
established
for
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
dichlorobenzoic
acid
and
expressed
as
parent
compound
in/
on
various
plant
and
animal
commodities
[
40
CFR
§
180.434].
The
reassessed
tolerances
will
be
expressed
as
propiconazole
per
se.
As
a
result,
in
some
cases
the
tolerance
levels
will
be
over
estimated,
due
to
the
fact
that
the
analytical
data
collection
method
is
a
moiety
method
that
detects
all
residues
convertible
to
2,4­
dichlorobenzoic
acid
(
DCBA),
and
the
field
data
were
reported
as
propiconazole
and
all
its
metabolites
containing
the
2,4­
DCBA,
as
a
result,
HED
is
unable
to
separate
out
the
parent
residue
from
the
metabolites
at
this
time.
HED
recommends
that
the
registrant
analyze
parent
and
metabolites
separately
in
all
future
field
trials,
so
that
more
realistic
tolerances
can
be
set
in
the
future.

With
the
exception
of
sunflower,
the
reregistration
requirements
for
magnitude
of
the
residue
in/
on
all
the
raw
agricultural
commodities
(
RACs),
based
on
the
currently
registered
use
patterns,
will
be
fulfilled
pending
label
revisions
and/
or
tolerance
adjustments:
barley,
rye,
rice,
wheat,
sweet
corn;
field
and
pop
corn,
oat,
peanut,
pineapple,
stone
fruits,
and
aspirated
grain
fractions.
As
a
result
of
this
review,
new
tolerances
are
being
proposed
on
several
commodities.
The
reregistration
requirements
for
magnitude
of
the
residue
in
the
processed
commodities
have
been
fulfilled,
except
for
pineapple
(
juice).
A
rice
processing
study
has
been
submitted
and
reviewed
by
the
Agency
as
acceptable.
The
reregistration
requirements
for
data
depicting
the
magnitude
of
propiconazole
residues
of
concern
in
meat,
milk,
poultry,
and
eggs
have
been
fulfilled.
The
maximum
theoretical
dietary
burden
to
livestock
has
been
recalculated
due
to
added
new
uses.
Tolerances
in
ruminant
commodities
were
reassessed
at
the
existing
level,
while
tolerances
for
poultry
commodities
are
not
required.
Plantback
restrictions
have
been
established
for
propiconazole
products
registered
for
use
on
rotatable
crops
based
on
the
confined
rotational
crop
studies.

Regulatory
Recommendations
and
Residue
Chemistry
Deficiencies
°
Amend
the
product
labels
for
the
41.8%
EC
formulations
to
indicate
the
propiconazole
concentration
in
terms
of
lb
ai/
gal.
In
addition,
the
following
products
have
label
restrictions
prohibiting
the
feeding
of
treated
forage
and/
or
hay
of
cereals
and
corn
to
livestock:
the
41.8%
EC
(
100­
617
and
100­
737)
and
the
45%
WP
(
100­
780)
formulations.
Such
restrictions
are
no
longer
permitted
and
must
be
removed.

°
The
maximum
number
of
applications
for
peanuts
on
Stratego
 
label
is
not
very
clear.
After
discussing
with
RD
and
the
registrant,
it
is
understood
that
the
maximum
number
of
six
applications
is
intended
only
for
the
7.0
oz
ai/
A
rate,
while
the
restricted
number
of
application
at
14
oz
ai/
A
is
only
two.
HED
recommends
that
the
registrant
to
amend
the
Stratego
 
label
to
specify
these
instructions.

°
HED
is
translating
the
wheat
grain,
wheat
straw,
wheat
hay
and
forage
data
to
barley
and
rye
grain,
straw,
hay
and
forage.
The
product
labels
for
the
41.8%
EC
(
EPA
Reg.
Nos.
100­
617
and
100­
737)
and
the
45%
WP
(
EPA
Reg.
No.
100­
780)
formulations
must
be
modified
to
make
the
use
patterns
for
barley
and
rye
identical
to
wheat.

°
The
use
directions
for
rice
on
all
labels
should
be
amended
to
specify
a
45­
day
PHI
.

°
HED
recommends
increasing
the
wheat
grain
tolerance
to
0.3
ppm,
wheat
straw
to
15.0
ppm,
and
to
propose
new
tolerances
on
wheat
hay
and
forage
at
2.0
ppm,
and
on
wheat
bran
at
1.0
ppm.

°
A
more
appropriate
level
for
the
oat
hay
tolerance
at
2.0
ppm
should
be
established
using
data
translated
from
wheat.
The
reassessed
tolerances
for
barley
grain
and
rye
grain
should
be
0.3
ppm,
for
barley
and
rye
straw
should
be
15.0
ppm.
New
tolerances
for
barley
hay
and
rye
forage
should
be
established
at
2.0
ppm.

°
The
available
rice
residue
data
support
the
established
3.0
ppm
tolerance
for
propiconazole
residues
in/
on
rice
straw;
however,
the
data
also
indicate
that
the
registrant
should
propose
increasing
the
tolerance
for
residues
in/
on
rice
grain.
An
appropriate
level
for
residues
in/
on
rice
grain
would
be
0.3
ppm.
The
registrant
needs
to
propose
new
tolerances
on
rice
grain
at
0.3
ppm,
rice
bran
at
1.0
ppm,
and
rice
hulls
at
1.2
ppm.
 
HED
recommends
a
5.0
ppm
tolerance
on
aspirated
grain
fractions
for
propiconazole.

°
The
use
on
sunflower
for
seeds
can
not
be
considered
non­
food
use,
and
therefore,
no
tolerance
can
be
established
on
sunflower
until
field
trial
data
are
submitted.

 
Pineapple
processing
study
is
required
to
determine
the
potential
for
concentration
in
pineapple
juice,
unless
field
trails
conducted
at
5x
the
maximum
application
rate
indicated
that
all
residues
are
less
than
LOQ.

 
The
registrant
has
generated
virtually
all
its
residue
data
using
a
common
moiety
method
that
converts
the
parent
and
all
of
the
metabolites
of
concern
to
2,4­
dichlorobenzoic
acid.
HED
recommends
that
the
registrant
analyze
parent
and
metabolites
separately
in
all
future
field
trials,
so
that
more
realistic
tolerances
can
be
set
in
the
future.
PROPICONAZOLE
PC
Code
No.
122101;
Case
3125
Reregistration
Eligibility
Decision
(
RED)
Document;
Residue
Chemistry
Considerations
Updated
by
EPA
June
15,
2006
Contract
No.
68­
D4­
0010
Submitted
to:
U.
S.
Environmental
Protection
Agency
Arlington,
VA
Submitted
by:
Dynamac
Corporation
The
Dynamac
Building
2275
Research
Boulevard
Rockville,
MD
20850­
3268
PROPICONAZOLE
REREGISTRATION
ELIGIBILITY
DECISION
RESIDUE
CHEMISTRY
CONSIDERATIONS
PC
Code
No.
122101;
Case
3125
TABLE
OF
CONTENTS
page
INTRODUCTION......................................................................................................................
2
REGULATORY
BACKGROUND
.............................................................................................
2
SUMMARY
OF
SCIENCE
FINDINGS......................................................................................
3
GLN
860.1200:
Directions
for
Use
...................................................................................
3
GLN
860.1300:
Nature
of
the
Residue
­
Plants................................................................
17
GLN
860.1300:
Nature
of
the
Residue
­
Animals
............................................................
18
GLN
860.1340:
Residue
Analytical
Methods...................................................................
22
GLN
860.1360:
Multiresidue
Methods............................................................................
22
GLN
860.1380:
Storage
Stability
Data............................................................................
22
GLN
860.1500:
Crop
Field
Trials....................................................................................
23
GLN
860.1520:
Processed
Food/
Feed.............................................................................
25
GLN
860.1480:
Meat,
Milk,
Poultry,
Eggs......................................................................
26
GLN
860.1400:
Water,
Fish,
and
Irrigated
Crops
............................................................
28
GLN
860.1460:
Food
Handling.......................................................................................
29
GLN
860.1850
and
860.1900:
Confined/
Field
Accumulation
in
Rotational
Crops............
29
TOLERANCE
REASSESSMENT
SUMMARY.......................................................................
41
Tolerances
Established
Under
40
CFR
§
180.434..............................................................
41
Tolerances
To
Be
Proposed
Under
40
CFR
§
180.434
......................................................
42
Time­
Limited
Tolerances
Established
Under
40
CFR
§
180.434(
b)....................................
43
Tolerances
with
Regional
Registrations
Established
Under
40
CFR
§
180.434(
c)
..............
43
Pending
Tolerance
Petitions
.............................................................................................
44
CODEX
HARMONIZATION...................................................................................................
51
.................................................................................................................................................
52
AGENCY
MEMORANDA
RELEVANT
TO
REREGISTRATION..........................................
53
MASTER
RECORD
IDENTIFICATION
NUMBERS..............................................................
67
2
PROPICONAZOLE
REREGISTRATION
ELIGIBILITY
DECISION
RESIDUE
CHEMISTRY
CONSIDERATIONS
PC
Code
No.
122101;
Case
3125
INTRODUCTION
Propiconazole
[
1­[[
2­(
2,4­
dichlorophenyl)­
4­
propyl­
1,3­
dioxolan­
2­
yl]
methyl]­
1H­
1,2,4­
triazole]
is
a
systemic
broad­
spectrum
fungicide
registered
for
treatment
of
disease
in
bananas
(
including
plantains),
barley,
celery,
corn
(
field,
pop,
and
sweet),
grasses
grown
for
seed,
mint,
oats,
peanuts,
pineapple,
rice
and
wild
rice,
rye,
stone
fruits,
sugarcane,
and
wheat.
Propiconazole
enduse
products
are
marketed
in
the
United
States
under
the
trade
names
Tilt
®
,
Alamo
®
,
Banner
®
,
and
Orbit
®
.
Recently,
propiconazole
is
also
registered
for
use
on
a
variety
of
crops
under
the
trade
names
of
Stratego
 
Twin­
Pak
 
and
Stratego
 
,
which
are
end­
use
products
containing
a
mixture
of
trifloxystrobin
and
propiconazole.
The
reregistration
of
propiconazole
is
being
supported
by
Syngenta
(
previously
Novartis
Crop
Protection,
Inc.),
the
basic
producer.
Uses
on
mint
and
mushrooms
are
being
supported
by
IR­
4.
The
propiconazole
formulations
registered
for
food/
feed
uses
include
emulsifiable
concentrate
(
EC)
and
flowable
concentrate
(
FlC)
formulations.

REGULATORY
BACKGROUND
The
Propiconazole
Phase
4
Review
dated
6/
25/
92
by
B.
Cropp­
Kohlligian,
F.
Fort,
and
F.
Toghrol
and
the
subsequent
Propiconazole
Data­
Call­
In
(
DCI)
Notice
dated
10/
6/
93
summarized
the
status
of
available
residue
chemistry
data
for
the
reregistration
of
propiconazole.
The
Phase
4
Review
identified
several
data
deficiencies
including
plant
and
animal
metabolism,
residue
analytical
methods,
storage
stability,
and
magnitude
of
the
residue
in
plants.
Several
studies
have
been
submitted
and
evaluated
in
response
to
the
Propiconazole
DCI;
in
addition,
uses
on
a
number
of
crops
have
been
registered
since
the
issuance
of
the
Phase
4
Review.
This
document
presents
an
overall
and
up­
to­
date
Residue
Chemistry
Science
Assessment
with
respect
to
the
reregistration
of
propiconazole.

Tolerances
are
established
for
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
dichlorobenzoic
acid
and
expressed
as
parent
compound
in/
on
various
plant
and
animal
commodities
[
40
CFR
§
180.434].
The
established
permanent
tolerances
for
plant
and
animal
commodities
[
40
CFR
§
180.434(
a)]
range
from
0.05
ppm
(
milk)
to
40
ppm
(
grass
hay).
Timelimited
tolerances,
due
to
expire
12/
31/
05,
are
established
for
cranberry,
dry
bean
forage,
dry
bean
hay,
and
dry
beans.
In
addition,
time­
limited
tolerances,
due
to
expire
06/
30/
05,
are
established
for
aspirated
grain
fractions
(
20
ppm),
sorghum
grain,
and
stover
[
40
CFR
§
180.434(
b)].
Timelimited
tolerances
are
being
recommended
to
established
in/
on
soybeans
at
0.5
ppm,
in/
on
soybean
forage
at
8
ppm,
and
in
soybean
hay
at
25
ppm.
And
in/
on
blueberry
at
1.0
ppm.
Tolerances
3
with
regional
registration
are
also
established
for
mint
at
0.3
ppm
and
wild
rice
at
0.5
ppm
[
40
CFR
§
180.434(
c)].
No
tolerances
are
established
for
rotational
crops
[
40
CFR
§
180.434(
d)].
This
document
does
not
include
recently
submitted
petitions.

SUMMARY
OF
SCIENCE
FINDINGS
GLN
860.1200:
Directions
for
Use
According
to
an
OPPIN
search,
there
are
228
active
registrations
for
propiconazole,
and
a
total
of
six
active
Syngenta
end­
use
products
(
see
Table
A1)
containing
the
active
ingredient
propiconazole
which
are
registered
for
use
on
domestically
grown
food/
feed
crops.
In
addition,
there
are
36
SLN
registrations
for
use
of
propiconazole
on
food/
feed
crops.

A
comprehensive
summary
of
propiconazole
food/
feed
use
patterns,
based
on
the
product
labels
registered
to
Syngenta,
is
presented
in
Table
A2.
A
tabular
summary
of
the
residue
chemistry
science
assessments
for
the
reregistration
of
propiconazole
is
presented
in
Table
B.
The
status
of
reregistration
requirements
for
each
guideline
topic
listed
in
Table
B
is
based
on
the
use
patterns
registered
by
the
basic
producer,
Syngenta
Crop
Protection,
Inc.

Table
A1.
Propiconazole
End­
Use
Products
with
Food/
Feed
Uses
Registered
to
Syngenta
Crop
Protection.

EPA
Reg.
No.
Label
Acceptance
Date
1
Formulation
2
Product
Name
100­
617
3
3/
99
(
10/
16/
97)
41.8%
(
3.6
lb/
gal)
EC
Tilt
®
Fungicide
100­
702
9/
96
41.8%
(
3.6
lb/
gal)
EC
Break
 
EC
Fungicide
100­
737
4
11/
95
41.8%
(
3.6
lb/
gal)
EC
Tilt
®
428C
or
428GS
Fungicide
100­
780
8/
99
45%
WP
Tilt
®
45W
100­
781
9/
96
45%
WP
Break
 
Fungicide
3125­
562
5
6/
01
11.4%
EC
Stratego
1
Date
of
the
most
recently
EPA­
approved
label
found
by
reviewer
in
the
product
jacket
or
Pesticide
Product
Label
System
(
PPLS).
2
None
of
the
labels
for
the
41.8%
EC
formulations
specify
concentration
in
terms
of
lb
ai/
gal;
the
value
in
parentheses
is
based
on
historical
data.
3
Including
SLN
Nos.
AL980003,
AR980001,
AR990002,
DE980002,
FL880016,
GA980003,
IA990002,
ID950012,
ID980004,
IL980001,
IL990006,
IL990008,
IN980003,
IN990003,
KS980002,
KS990008,
KY980002,
MI980001,
MI990003,
MN980003,
MN990014,
MO980003,
MS980004,
NE990006,
ND980002,
OH980002,
TN980004,
TX980001,
VA980003,
WA950033,
WA980018,
and
WI990015.
4
Also
packaged
as
Tilt
®
Gel
in
water­
soluble
packets.
Including
SLN
Nos.
OR960013
and
OR960007.
5
Including
ND­
010009,
MN­
010007,
OH­
02001,
WA­
030015,
KS­
010002,
VA­
100002,
TX010009,
AR­
010005,
GA­
010002,
IN­
020001,
AL­
000003
In
addition
to
the
products
listed
above,
SLN
products
HI910009
and
PR930001,
registered
for
use
on
bananas,
are
formulated
from
an
unregistered
source
product,
Tilt
®
250
EC
Fungicide.
Included
in
the
product
jackets
for
these
products
are
Confidential
Statements
of
Formula
for
the
4
source
product.
We
note
that
information
reflecting
the
active
ingredient
content
in
terms
of
lb
ai/
gal
is
not
presented
on
either
label.

The
above
labels
specify
a
re­
entry
interval
(
REI)
of
24
hours,
except
for
the
45%
WP
(
EPA
Reg.
Nos.
100­
780
and
100­
781)
formulations
which
specify
an
REI
of
12
hours.

The
41.8%
EC
(
EPA
Reg.
Nos.
100­
617
and
100­
737)
and
the
45%
WP
(
EPA
Reg.
No.
100­
780)
are
the
only
products
currently
registered
for
use
on
rotatable
crops.
Labels
for
these
formulations
specify
that
soybeans
may
be
planted
as
a
double
crop
following
a
cereal
crop
which
has
been
treated
with
the
product,
but
soybean
hay,
forage,
and
fodder
may
not
be
used
as
any
component
of
animal
feed
or
bedding.
The
labels
specify
that
any
food/
feed
crops
not
listed
on
the
label
should
not
be
planted
within
105
days
of
treatment.

Syngenta
is
required
to
amend
the
product
labels
for
the
41.8%
EC
formulations
to
indicate
the
propiconazole
concentration
in
terms
of
lb
ai/
gal.
In
addition,
the
following
products
have
label
restrictions
prohibiting
the
feeding
of
treated
forage
and/
or
hay
of
cereals
and
corn
to
livestock:
the
41.8%
EC
(
100­
617
and
100­
737)
and
the
45%
WP
(
100­
780)
formulations.
Such
restrictions
are
no
longer
permitted
and
must
be
removed.
Label
amendments
are
also
required
to
incorporate
the
parameters
of
use
patterns
reflected
in
the
submitted
field
trials;
details
of
the
crop­
specific
label
amendments
are
presented
in
the
respective
endnotes
for
each
crop
(
GLN
860.1500:
Crop
Field
Trials)
in
Table
B.

Propiconazole
can
be
mixed
with
other
fungicides.
Formulations
which
contain
both
propiconazole
and
trifloxystrobin
(
e.
g.
Stratego
 
Twin­
Pak
 
and
Stratego
 
Fungicide,
EPA
Reg.
Nos.
264­
779
)
have
been
registered
for
uses
on
corn,
peanuts,
pecans,
rice,
and
wheat.
The
use
patterns
are
shown
in
Table
A2.
These
uses
were
registered
based
on
reviews
of
trifloxystrobin.
Residue
data
for
trifloxystrobin
were
reviewed
in
PP#
9F5070
(
DP
Barcodes
D254213,
D254217,
D254218,
and
D254221,
4/
6/
00,
L.
Cheng).
After
comparing
the
use
rates
of
Stratego
 
Twin­
Pak
 
and
Stratego
 
on
corn,
peanuts,
pecans
and
rice
to
the
use
rates
which
current
tolerances
on
corn,
peanuts,
pecans
and
rice
are
based
on,
HED
concludes
that
the
Stratego
 
use
rates
on
these
crops
are
below
the
use
rates
which
tolerances
are
based
on,
except
for
wheat.
Residue
data
for
propiconazole
on
wheat
have
been
recently
reviewed
by
Y.
Donovan
(
HED
memo
of
02/
02/
05,
Y.
Donovan,
D271790).
Since
there
are
adequate
field
trial
data
to
support
Section
3
registration
of
propiconazole
uses
on
wheat
at
the
rate
of
0.08
­
0.11
lbs
ai/
A/
application,
maximum
2
applications,
and
35
day
PHI
(
HED
memo
of
02/
02/
05,
Y.
Donovan,
D271790),
HED
can
support
the
label
use
direction
changes
provided
that
the
existing
tolerances
on
wheat
RAC
are
raised.
These
new
reassessed
tolerances
will
cover
all
24C
uses
on
wheat
as
well.
HED
recommends
to
cancel
all
24C
uses
while
revising
the
Section
3
label
to
include
these
24C
uses.

HED
notice
that
the
maximum
number
of
applications
for
peanuts
on
Stratego
 
label
is
not
very
clear.
After
discussing
with
RD
and
the
registrant,
it
is
understood
that
the
maximum
number
of
six
applications
is
intended
only
for
the
7.0
oz
ai/
A
rate,
where
the
5
restricted
number
of
application
at
14
oz
ai/
A
is
only
two.
HED
recommends
that
the
registrant
to
amend
the
Stratego
 
label
to
specify
these
instructions.

HED
is
translating
the
wheat
grain,
wheat
straw,
wheat
hay
and
forage
data
to
barley
and
rye
grain,
straw,
hay
and
forage.
The
product
labels
for
the
41.8%
EC
(
EPA
Reg.
Nos.
100­
617
and
100­
737)
and
the
45%
WP
(
EPA
Reg.
No.
100­
780)
formulations
must
be
modified
to
make
the
use
patterns
for
barley
and
rye
identical
to
wheat.

For
the
purpose
of
generating
this
Residue
Chemistry
Science
Chapter,
HED
examined
the
registered
food/
feed
use
patterns
of
the
basic
producer
and
reevaluated
the
available
residue
chemistry
database
for
adequacy
in
supporting
these
use
patterns.
When
end­
use
product
DCIs
are
developed
(
e.
g.,
at
issuance
of
the
RED),
RD
should
require
that
all
end­
use
product
labels
(
e.
g.,
MAI
labels,
SLNs,
and
products
subject
to
the
generic
data
exemption)
be
amended
such
that
they
are
consistent
with
the
basic
producer
labels.

The
use
directions
for
rice
on
all
labels
should
be
amended
to
specify
a
45­
day
PHI
(
HED
memo
of
02/
23/
05,
T.
Morton,
D240856).
6
Table
A2
Food/
Feed
Use
Patterns
on
EP
Labels
Subject
to
Reregistration
for
Propiconazole
(
Case
3125).

Site
Application
Type
Application
Equipment
Formulati
on
1
[
EPA
Reg.

No.]
Maximum
Single
Application
Rate
(
lb
ai/
A)
Maximum
Number
of
Applications
Per
Season
Maximum
Seasonal
Rate
(
lb
ai/
A)
Preharvest
Interval
(
days)
Use
Directions
and
Limitations
2
Bananas
and
Plantains
Preharvest
foliar
Ground
41.8%
EC
[
PR40005]
0.086
8
NS
NS
Apply
before
disease
symptoms
appear
at
the
onset
of
the
rainy
season.
Apply
3
fl.
oz.
per
acre.
Apply
no
more
than
2
consecutive
applications
on
a
21­
25
day.
Apply
up
to
8
applications.
Applications
should
be
made
using
an
orchard
oil
and
an
emulsifier.

Applications
within
100
yards
of
non­
bagged
bananas
or
directly
to
non­
bagged
bananas
are
prohibited.

celery
Preharvest
foliar
Ground
or
aerial
41.8%
EC
(
3.6
lb
ai/
gal)

[
100­
617]

[
100­
737]

45%
WP
[
100­
780]
0.1125
4
0.45
14
Apply
multiple
treatments
on
a
7­
day
schedule.
May
be
tank­
mixed
with
a
spreader­
sticker.
Applications
should
be
made
using
a
minimum
of
10
(
ground)
or
5
(
aerial)
gal
of
water/
A.

Foliar
Quilt
[
100­
1178]
0.1138
NS
0.45
7
Aerial,
ground,
and
sprinkler
irrigation
Cereals
(
Including
Wheat,
Barley,
Triticale,
and
Rye)
7
Preharvest
foliar
Ground
or
aerial
41.8%
EC
(
3.6
lb
ai/
gal)

[
100­
617]

[
100­
737]

45%
WP
[
100­
780]
0.1125
NS
0.167
NS
Highest
yields
when
applied
to
the
emerging
flag
leaf;
do
not
apply
after
the
ligule
of
the
flag
leaf
emerges
(
Feekes
growth
stage
9)
on
barley
,
rye,
oats
and
triticale.
For
wheat
only,
Tilt
can
be
applied
until
full
head
emergence
(
Feekes
growth
stage
10.5).

Grazing
or
feeding
livestock
treated
forage
or
cutting
the
green
crop
for
hay
or
silage
is
prohibited;
following
harvest,
straw
may
be
used
for
bedding
or
feed.
Applications
should
be
made
in
a
minimum
of
10
(
ground)

or
5
(
aerial)
gal.
of
water/
A.

Corn
(
Including
Field
Corn,
Field
Corn
Grown
for
Seed,
Sweet
Corn,
and
Popcorn)

Preharvest
foliar
Ground
or
aerial
41.8%
EC
(
3.6
lb
ai/
gal)

[
100­
617]

[
100­
737]

45%
WP
[
100­
780]
0.1125
NS
0.45
14
(
sweet
corn)
Treatment
should
be
started
when
disease
appears
and
repeated
on
a
7­
to
14­
day
schedule.
Application
to
field
corn
and
field
corn
grown
for
seed
after
silking
is
prohibited.
Harvest
of
forage
from
field
corn,
field
corn
grown
for
seed,
and
popcorn
within
30
days
of
application
and
of
sweet
corn
forage
within
14
days
of
application
is
prohibited.
Applications
should
be
made
in
a
minimum
of
10
(
ground)
or
5
(
aerial)
gal
of
water/
A.
8
Preharvest
foliar
Ground
or
aerial
(
post
silk)
41.8%
EC
(
3.6
lb
ai/
gal)

[
LA990002]

[
KS030002]

[
MN990014]

[
NE990006]

[
IL040004]
0.1125
NS
0.45
14
(
sweet
corn)

30
(
seed,

field,
and
popcorn)
Treatment
should
be
started
when
disease
appears
and
repeated
on
a
7­
to
14­
day
schedule.
Feeding
livestock
treated
forage
or
fodder
and
harvest
of
sweet
corn
forage
within
14
days
of
application
are
prohibited.

Applications
should
be
made
in
a
minimum
of
10
(
ground)
or
5
(
aerial)
gal
of
water/
A.

Between
V4
to
after
silking
Stratego
R
[
264­
779]
0.1125
NS
0.29
30(
forage
)
before
silking
Corn
Grown
for
Seed
(
See
Also
"
Corn")

Preharvest
foliar
Ground
or
aerial,
and
sprinkler
irrigation
41.8%
EC
(
3.6
lb
ai/
gal)

[
IN990003]
0.1125
NS
0.45
30
Treatment
should
be
started
when
disease
appears
and
repeated
on
a
7­
to
14­
day
schedule.
Making
more
than
two
applications
after
50%
silk
and
feeding
livestock
treated
forage
or
fodder
are
prohibited.
Applications
should
be
made
in
a
minimum
of
10
(
ground)
or
5
(
aerial)
gal
of
water/
A.

Preharvest
foliar?
Tilt
0.1125
NS
0.45
7
When
disease
first
appears.
Aerial,
ground,

and
sprinkler
irrigation.

Grasses
Grown
for
Seed
9
Preharvest
foliar
Ground
or
aerial
41.8%
EC
(
3.6
lb
ai/
gal)

[
100­
617]

[
100­
737]

45%
WP
[
100­
780]
0.225
(
0.1125­
bluegrass)
NS
0.9
20
Use
is
limited
to
ID,
MN,
NE,
OR,
and
WA.

Apply
multiple
treatments
on
a
14­
to
21­
day
schedule.
The
feeding
of
treated
hay
is
prohibited
within
20
days
of
the
last
application,
and
the
grazing
of
treated
areas
is
prohibited
within
140
days.
Applications
should
be
made
in
a
minimum
of
20
(
ground)

or
10
(
aerial)
gal
of
water/
A.

Preharvest
foliar
Ground
or
aerial
41.8%
EC
(
3.6
lb
ai/
gal)

[
ID950012]

[
OR050012]

[
WA950033]

[
IN990003]

[
NV010004]

[
MT030004]
0.225
2
0.45
20
Apply
just
prior
to
anthesis.
Make
second
application
7­
10
days
later.
Should
be
tank
mixed
with
an
appropriate
surfactant.
The
feeding
of
treated
hay
is
prohibited
within
20
days
of
the
last
application,
and
the
grazing
of
treated
areas
is
prohibited
within
140
days.

Applications
should
be
made
in
a
minimum
of
20
(
ground)
or
10
(
aerial)
gal
of
water/
A.

Mint
Preharvest
foliar
Ground
41.8%
EC
(
3.6
lb
ai/
gal)

[
OR050011]
0.1125
NS
0.225
90
Apply
when
plants
are
2­
4"
high.
Make
second
application
10­
14
days
later.

Applications
should
be
made
in
a
minimum
of
20
gal
of
water/
A.

Nectarines
(
See
"
Stone
fruits")

Oats
Preharvest
foliar
Ground
or
aerial
41.8%
EC
(
3.6
lb
ai/
gal)

[
100­
617]
0.1125
NS
0.1125
40
Highest
yields
when
applied
to
the
emerging
flag
leaf;
do
not
apply
after
the
ligule
of
the
flag
leaf
emerges
(
Feekes
growth
stage
8).

Applications
should
be
made
in
a
minimum
of
10
(
ground)
or
5
(
aerial)
gal
of
water/
A.

Peaches
(
See
"
Stone
fruits")
10
Peanuts
Preharvest
foliar
Chemigation
or
directed
ground
41.8%
EC
(
3.6
lb
ai/
gal)

[
100­
617]

45%
WP
[
100­
780]
0.225
2
0.45
21
Apply
to
crown
and
pegging
zones.
Begin
applications
45
or
60
days
after
planting
or
at
the
first
appearance
of
disease;
make
second
application
14
days
or
3­
4
weeks
later.

Grazing
livestock
or
feeding
hay
or
threshings
to
livestock
are
prohibited.

Applications
should
be
made
in
a
minimum
of
20
(
ground)
gal
of
water/
A.

Preharvest
foliar
Ground
or
aerial
41.8%
EC
(
3.6
lb
ai/
gal)

[
100­
617]

[
100­
737]

45%
WP
[
100­
780]
0.1125
NS
0.45
14
Begin
applications
35­
40
days
after
planting
and
repeat
on
a
10­
to
14­
day
schedule.

Grazing
of
livestock
or
feeding
green
vines
to
livestock
is
prohibited.
Applications
should
be
made
in
a
minimum
of
10­
20
(
ground)
or
5
(
aerial)
gal
of
water/
A.

Preharvest
foliar
Ground
or
aerial
Stratego
R
[
264­
779]
0.1134
6
0.68
14
Pecans
Preharvest
foliar
Ground
or
aerial
Stratego
R
[
264­
779]

Tilt
[
100­
617]

Quilt
[
100­

1192]
0.081
NS
0.24
30
Apply
on
a
14­
day
schedule
during
bud
break,
prepollination
sprays,
or
during
nut
formation
and
cover
sprays.
Use
higher
rates
when
disease
pressure
is
heavier.
Do
not
apply
after
shuck
split.
Grazing
of
livestock
in
treated
areas
or
cutting
treated
cover
crops
for
feed
is
prohibited.
Application
should
be
made
using
a
minimum
of
20
gal.
of
water/
A.

Pineapple
11
Postharvest
Cold
or
hot
water
dip
(
Seed
treatment)
45%
WP
[
100­
780]
0.1125
lb
ai/
500
gal
water
N/
A
N/
A
N/
A
Use
is
limited
to
HI;
immerse
or
soak
crowns
for
control
of
disease.
Feeding
livestock
treated
crowns
or
grazing
livestock
on
growing
plants
or
tops
before
fruit
is
harvested
is
prohibited.

Plantains
(
See
"
Bananas
and
Plantains")

Plums
(
See
"
Stone
fruits")

Rice
Preharvest
foliar
Aerial
41.8%
EC
(
3.6
lb
ai/
gal)

[
100­
617]

[
100­
737]
0.2813
2@
0.1688
lb
ai/
A
or
1@
0.2813
lb
ai/
A
NS
NS
If
 
5%
of
tillers
are
infected,
two
applications
should
be
made,
the
first
application
at
first
internode
elongation
(
up
to
2­
inch
panicle)

and
the
second
at
swollen
boot
(
10­
14
days
following
the
first
but
before
the
boot
splits
and
head
emerges).
If
greater
than
10%
of
the
tillers
are
infected,
the
higher
single
application
rate
should
be
made
at
first
internode
elongation.
Use
is
prohibited
in
CA
and
areas
of
the
following
AR
counties:

Mississippi,
Poinsett,
Cross,
St.
Francis,
and
Lee.
The
following
are
prohibited:
use
in
rice
fields
where
commercial
farming
of
crayfish
is
practiced;
draining
water
from
treated
rice
fields
into
ponds
used
for
commercial
catfish
farming;
application
to
stubble
or
ratoon
crop
rice;
and
use
of
water
drained
from
treated
fields
to
irrigate
other
crops.
Applications
should
be
made
in
a
minimum
of
5
gal
of
water/
A.

Stratego
R
[
264­
779]
0.16
NS
0.31
35
12
Rye
(
See
"
Cereals")

Stone
Fruits
(
Sweet
or
tart
Cherry,
Apricots,
Nectarines,
Peaches,
and
Plums
or
Prune)

Preharvest
foliar
Ground
or
aerial
41.8%
EC
(
3.6
lb
ai/
gal)

[
100­
702]

45%
WP
[
100­
781]
0.1125
2
Not
Specified
(
NS)
0
Use
is
restricted
to
West
of
the
Rocky
Mountains
for
EPA
reg#
100­
781.
Two
applications
may
be
made
during
the
period
beginning
10­
14
days
before
harvest
through
the
day
of
harvest;
or
the
first
application
may
be
made
at
early
bloom
stage.
A
second
application
may
be
made
as
needed
through
petal
fall.
Applications
should
be
made
using
a
minimum
of
50
(
ground)
or
20
(
aerial)
gal
of
water/
A.

Sugarcane
Postharvest
Cold
or
hot
water
dip
45%
WP
[
100­
780]
0.1125
lb
ai/
500
gal
water
N/
A
N/
A
N/
A
Use
of
the
federal
label
is
limited
to
HI.

Immerse
or
soak
cut
seed
pieces
for
control
of
disease.
Use
of
treated
seed
pieces
for
food
or
feed
is
prohibited.

Sunflower
(
Breeder's
seed)

Foliar
spray
Tilt
[
IL050002]

[
TX000006]
0.1125
0.45
N/
A
N/
A
Foliar
spray,
When
disease
first
appears.
7­

day
retreatment
interval.

Wheat
(
See
also
"
Cereals")
13
Preharvest
foliar
Ground
or
aerial
41.8%
EC
(
3.6
lb
ai/
gal)

[
AR990002]

[
GA980003]

[
ID980004]

[
IN980003]

[
MI980001]

[
MN980003]

[
MS980004]

[
VA980003]

[
WA980018]

Tilt
[
100­
617]

[
AR030008]

[
MO980003]

[
KS030001]

[
OK010002]

[
TN030002]

[
OH040002]

[
DE030003]

[
KY050002]
0.1125
NS
0.1125
40
Highest
yields
when
applied
to
the
emerging
flag
leaf;
do
not
apply
after
full
head
emergence
(
Feekes
growth
stage
10.5).

Grazing
or
feeding
livestock
treated
forage
or
cutting
the
green
crop
for
hay
or
silage
is
prohibited;
following
harvest,
straw
may
be
used
for
bedding
or
feed.
Applications
should
be
made
in
a
minimum
of
15
(
ground)

or
5
(
aerial)
gal
of
water/
A.
14
Wheat
(
cont'd.)

Preharvest
foliar
Ground
or
aerial
Quilt
[
100­

1178]

[
AR050001]

[
WA040026]

[
MS040011]

[
AL040002]

[
OK040001]

[
GA040003]

[
TN040004]

[
MO040006]

[
TX040022]

[
ID050007]
0.1125
NS
0.1125
40
Highest
yields
when
applied
to
the
emerging
flag
leaf;
do
not
apply
after
late
boot,
sheath
split
stage
(
Feekes
growth
stage
10.0).

Grazing
or
feeding
livestock
treated
forage
or
cutting
the
green
crop
for
hay
or
silage
is
prohibited;
following
harvest,
straw
may
be
used
for
bedding
or
feed.
Applications
should
be
made
in
a
minimum
of
15
(
ground)

or
5
(
aerial)
gal
of
water/
A.

Trifloxystrobin
registration
(
coactive
ingredient
with
propiconazole)
Stratego
R
[
264­
779]
0.081
2
0.162
35
(
grain)

30
(
forage)

45
(
hay)

35
(
straw)
15
Preharvest
foliar
Ground
or
aerial
(
Section
24C)
Stratego
[
3125­
562)

ND­
010009
MN­
010007
OH­
02001
WA­
030015
KS­
010002
VA­
100002
TX010009
AR­
010005
GA­
010002
IN­
020001
AL­
000003
0.081
1
0.081
35
(
grain)

30
(
forage)

45
(
hay)

35
(
straw)

Wild
Rice
Preharvest
foliar
Aerial
41.8%
EC
(
3.6
lb
ai/
gal)

[
100­
617]

[
100­
737]

45%
WP
[
100­
780]
0.225
2@
0.1688
lb
ai/
A
or
1@
0.225
lb
ai/
A
NS
NS
Use
is
limited
to
MN.
Applications
should
be
made
at
booting
and
heading,
or
a
single
application
may
be
made
at
the
higher
rate
at
booting.
Use
of
water
drained
from
treated
rice
fields
to
irrigate
other
crops
is
prohibited.
Applications
should
be
made
in
a
minimum
of
5
gal
of
water/
A.

Note:

1
The
41.8%
EC
formulations
have
been
determined
to
contain
3.6
lb
ai/
gal
of
propiconazole
based
on
historical
data.

2
Product
labels
specify
a
re­
entry
interval
(
REI)
of
24
hours,
except
for
the
45%
WP
(
EPA
Reg.
Nos.
100­
780
and
100­
781)
formulations
which
specify
an
REI
of
12
hours.
Propiconazole
may
be
tank
mixed
with
other
fungicides;
however
labels
for
EPA
Reg.
Nos.
100­
702
and
100­
781
state
that
tank
mixing
with
Cyprex
®
may
cause
crop
injury.

³
The
41.8%
EC
(
EPA
Reg.
Nos.
100­
617
and
100­
737)
and
the
45%
WP
(
EPA
Reg.
No.
100­
780)
are
the
only
products
currently
registered
for
use
on
rotatable
crops.
The
labels
for
these
formulations
state
that
soybeans
may
be
planted
as
a
double
crop
following
a
cereal
crop
which
has
been
treated
with
the
product,
but
soybean
hay,
forage,
and
fodder
may
not
be
used
as
any
component
of
animal
feed
or
bedding.
The
labels
specify
that
any
food/
feed
crops
not
listed
on
the
label
should
not
be
planted
within
105
days
of
treatment.
16
GLN
860.1300:
Nature
of
the
Residue
­
Plants
Previous
metabolism
studies
on
peanuts,
wheat,
grapes,
and
rice
demonstrated
that
similar
metabolites
were
present
in
both
the
primary
and
rotational
crops;
however,
quantitative
information
was
not
provided
to
calculate
the
percentage
of
uncharacterized
residues.
The
Propiconazole
Phase
4
Review
required
that
additional
metabolism
studies
be
conducted
on
wheat,
bananas,
and
pecans;
however,
on
further
consideration
of
the
original
data
for
peanuts,
wheat,
grapes,
and
rice,
the
Agency
concluded
(
DP
Barcode
D198815,
4/
26/
94,
F.
Fort)
that
an
additional
celery
metabolism
study
would
be
adequate
to
determine
the
metabolic
pathway
in
plants.
Because
only
a
small
amount
of
propiconazole
was
metabolized
in
celery,
the
registrant
submitted
an
additional
wheat
metabolism
study
to
further
delineate
the
nature
of
the
residue
of
propiconazole
in
plants.
The
reregistration
requirements
for
plant
metabolism
are
fulfilled
based
on
acceptable
metabolism
studies
reflecting
foliar
treatment
of
propiconazole
on
celery
and
wheat.

Available
plant
metabolism
data
(
primary
and
rotated
crops)
show
that
plants
absorb,
metabolize
and
translocate
propiconazole
throughout
the
plant.
A
major
metabolic
pathway
in
plants
appears
to
be
hydroxylation
(
primarily
of
the
beta­
carbon)
of
the
n­
propyl
group
on
the
dioxolane
ring
of
the
cis/
trans
isomers
of
propiconazole.
These
metabolites
appear
to
readily
form
sugar
conjugates.
The
majority
of
TRR
was
found
in
the
stalks,
such
as
peanut
stalk,
wheat
forage
and
straw,
grape
leaves,
and
celery
stalks.
A
possible
alternative
pathway
involves
reductive
deketalization
of
the
dioxolane
ring
and
sugar
conjugation
of
the
resulting
metabolite.
The
alkyl
bridge
between
the
phenyl
and
triazole
rings
is
metabolized
and
free
triazole,
as
1H­
1,2,4­
triazole,
is
released.
The
freetriazole
is
readily
conjugated
with
the
amino
acid,
serine/
alanine,
forming
triazole
aniline
which
is
further
metabolized
to
triazole
acetic
acid
possibly
through
the
intermediate
formation
of
triazole
lactic
acid.
As
mentioned
earlier,
the
triazole
issue
will
be
addressed
separately.
The
HED
MARC
concluded
that
residues
of
propiconazole
and
all
its
metabolites
containing
the
2,4­
dichlorophenyl
moiety
(
2,4­
DCBA),
including
conjugates,
are
of
concern
and
should
be
included
in
the
dietary
(
food)
risk
assessments
for
propiconazole,
due
to
the
fact
that
the
registrant
has
generated
virtually
all
its
residue
data
using
a
method
that
converts
the
parent
and
all
of
the
metabolites
of
concern
to
a
common
moiety,
2,4­
DCBA.
MARC
was
in
agreement
that
the
metabolites
that
have
the
basic
structure
of
propiconazole
(
e.
g.
alkanol,
betahydroxy
and
conjugates)
would
likely
exhibit
some
of
the
same
toxicity
as
the
parent
compound,
but
would
not
likely
be
more
toxic
than
the
parent
compound.
For
the
purposes
of
risk
assessment
HED
would
assume
these
metabolites
would
have
equal
toxicity
as
the
parent
compound.
(
The
conjugates
are
included
because
of
the
possibility
they
could
be
hydrolyzed
in
the
stomach
to
the
unconjugated
form).
Only
residues
of
propiconazole
per
se
should
be
included
in
the
dietary
(
water)
risk
assessments
(
HED
memo
of
04/
04/
02,
B.
Cropp­
Kohlligian,
D279299).
For
tolerance
expression,
MARC
concluded
that
the
current
tolerance
expression
for
propiconazole
should
be
amended
to
include
residues
of
propiconazole
per
se
only
for
the
following
reasons:
1)
there
are
a
number
of
pesticides
that
have
2,4­
DCBA
as
common
metabolite.
An
enforcement
agency
may
not
be
able
to
determine
if
residues
are
due
to
misuse
of
propiconazole
or
the
proper
use
of
other
pesticides
containing
2,4­
DCBA;
2)
the
FDA
17
multiresidue
method
detects
parent
only;
3)
to
harmonize
with
the
Codex
MRL
which
includes
parent
only.
In
rotational
crops,
the
most
blatent
misuse
of
propiconazole
would
be
application
to
unlabeled
crops.
If
rotational
crop
tolerances
are
expressed
in
terms
of
parent,
then
any
residues
of
propiconazole
on
rotated
crops
would
likely
be
due
to
direct
application
to
these
crops.

GLN
860.1300:
Nature
of
the
Residue
­
Animals
The
reregistration
requirements
for
animal
metabolism
are
fulfilled
based
on
acceptable
goat
and
poultry
metabolism
studies.
These
studies
were
initially
reviewed
in
conjunction
with
the
following
tolerance
petitions:
PP#
4F3007,
PP#
1F3974,
and
PP#
8F3674
(
poultry),
and
were
summarized
in
the
Propiconazole
Phase
4
Review.
For
one
ruminant
study,
three
lactating
goats
received
[
phenyl­
14C]
propiconazole
at
67­
92
ppm
for
four
consecutive
days
in
feed.
The
dosing
levels
correspond
to
2.5­
3.3x
the
maximum
theoretical
dietary
burden
to
dairy
cattle
(
see
"
Meat,
Milk,
Poultry,
Eggs").
The
parent
(
1.7­
13.9%
TRR),
and
metabolites
CGA­
118244
(
9.4­
34%
TRR),
and
CGA­
91305
(
15.9­
31.3%
TRR)
were
identified
in
the
organic
extract
of
tissues;
metabolites
CGA­
118244
(
23%
TRR)
and
CGA­
91305
(
24%
TRR)
were
also
identified
in
milk.
In
addition,
an
unknown
was
quantitated
(
6.2­
31.1%
TRR)
in
goat
tissues.
In
a
second
ruminant
study,
a
single
goat
was
fed
[
triazole­
14C]
propiconazole
at
4.53
ppm
(
0.2x)
for
10
days.
The
TRR
in
tissues
and
milk
ranged
from
0.01
ppm
in
muscle
to
0.96
ppm
in
liver;
TRR
in
milk
were
0.015
ppm.
On
further
analysis
of
subsamples
of
milk
and
liver,
sulfate
and
glucuronide
conjugates
were
found
in
milk,
and
conjugation
with
amino
acids
was
suggested
in
liver;
propiconazole
per
se
was
not
identified
in
milk
or
liver.

For
the
poultry
study,
four
laying
hens
received
[
phenyl­
14C]
propiconazole
at
67
ppm
for
eight
consecutive
days
in
feed.
The
dosing
level
corresponds
to
560x
the
maximum
theoretical
dietary
burden
to
poultry.
The
parent
(
1.4­
39.0%
TRR),
and
metabolites
CGA­
118244
(
1.5­
50.0%
TRR),
and
CGA­
91305
(
17.7­
78.6%
TRR)
were
identified
in
the
organic
extracts
of
tissues
and
eggs.

MARC
concluded
that
parent
and
all
metabolites
convertible
to
2,4­
DCBA
are
residues
of
concern
for
risk
assessment,
since
the
analytical
method
is
a
moiety
method
that
detects
all
residues
convertible
to
2,4­
dichlorobenzoic
acid
(
DCBA).
For
tolerance
expression,
MARC
concluded
that
the
current
tolerance
expression
for
propiconazole
should
be
amended
to
include
residues
of
propiconazole
per
se
only
for
the
same
reasons
as
described
above
in
plants.
In
addition,
if
only
propoiconazole
per
se
is
regulated,
there
will
not
likely
be
a
need
for
meat
and
milk
tolerances;
only
meat
by­
products
would
likely
require
a
tolerance.
Should
there
be
detectable
residues
of
the
parent
compound
in
meat
and
milk,
it
would
most
certainly
be
as
a
result
of
a
misuse.

The
chemical
names
and
structures
of
propiconazole
and
its
metabolites
in
animal
commodities
are
depicted
in
Figure
A.

HED
MARC
Meeting
Summary
Chart
18
Chemical:
Propiconazole
Date:
18­
Dec­
2001,
and
08­
Jan­
2002
Residues
of
Concern
Matrix
For
Risk
Assessment

For
Tolerance
Expression
Plants
Parent
plus
all
metabolites
convertible
to
2,4­
DCBA
Parent
only
Rotational
crop
Parent
plus
all
metabolites
convertible
to
2,4­
DCBA
Parent
only
Livestock:
Parent
plus
all
metabolites
convertible
to
2,4­
DCBA
Parent
only
Water
Parent
only
N/
A

Triazole
is
also
residue
of
concern,
but
it
will
be
addressed
separately.
19
Figure
A.
Chemical
Names/
Codes
and
Structures
of
Propiconazole
Residues
of
Concern
in
Plant
and
Animal
Commodities.

Common
Name/
Code
Chemical
Name
Chemical
Structure
Matrices
Propiconazole;
CGA­
64250
1­[[
2­(
2,4­
dichlorophenyl)­
4­
propyl­
1,3­
dioxolan­
2­
yl]
methyl]­
1H­
1,2,4­
triazole
Cl
Cl
O
O
N
N
N
CH
3
Celery
Wheat
forage,
straw,
chaff
and
grain
Goat
liver,
kidney,
muscle,
and
fat
Poultry
eggs,
liver,
kidney,
muscle,
and
fat
CGA­
91304
Cl
Cl
O
N
N
N
Celery
Wheat
forage,
straw,
chaff,
and
grain
CGA­
91305
Cl
Cl
OH
N
N
N
Celery
Wheat
forage,
straw
and
chaff
Goat
milk,
liver,
kidney,
muscle,
and
fat
Poultry
eggs,
liver,
kidney,
muscle,
and
fat
CGA­
118244
Cl
Cl
O
O
N
N
N
CH
3
OH
Celery
Wheat
forage,
straw,
chaff,
and
grain
Goat
milk,
liver,
kidney,
muscle,
and
fat
Poultry
eggs,
liver,
kidney,
muscle,
and
fat
CGA­
118245
Wheat
forage,
straw,
chaff,
and
grain
20
Common
Name/
Code
Chemical
Name
Chemical
Structure
Matrices
Cl
Cl
O
O
N
N
N
OH
CGA­
136735
Cl
Cl
O
O
N
N
N
CH
3
O
H
Wheat
straw
GB­
XLIII­
42­
1
Wheat
forage
and
straw
21
GLN
860.1340:
Residue
Analytical
Methods
Plant
commodities:
Residue
methods
AG­
454,
AG­
454B
and
AG­
626
(
both
are
modification
of
method
AG­
454)
were
used
to
determination
residues
of
propiconazole
and
its
metabolites
on
samples
of
raw
agricultural
and
processed
commodities
from
field
trials
and
processing
studies.
The
methods
use
a
single
moiety
detection
in
which
residues
are
converted
to
2,4­
DCBA,
determined
as
the
2,4­
DCBA
methyl
ester,
and
reported
as
propiconazole
equivalents
using
a
conversion
factor
of
1.79.
The
reported
method
LOQ
is
0.05
ppm.
Concurrent
method
recoveries
were
acceptable.

In
the
Phase
4
Review,
the
registrant
was
required
to
conduct
enforcement
method
validation
for
Method
AG­
454A
using
bananas.
These
data
are
no
longer
needed.

For
enforcement
purposes,
residue
method
AG­
354
is
available
for
the
determination
of
propiconazole
per
se
in/
on
plant
commodities
using
gas
chromatography
and
flame
ionization
detection,
and
the
reported
LOQ
is
0.05
ppm.
The
Multiresidue
Methods
Section
302
(
Luke
Method;
Protocol
D)
picks
up
parent
propiconazole
as
well.

Animal
commodities:
Residue
methods
AG­
517
and
AG­
629
(
a
modification
of
method
AG­
517)
were
used
for
determination
of
propiconazole
and
its
metabolites
in
animal
commodities.
The
methods
use
a
single
moiety
detection
in
which
residues
are
converted
to
2,4­
DCBA,
determined
as
the
2,4­
DCBA
methyl
ester,
and
reported
as
propiconazole
equivalents
using
a
conversion
factor
of
1.79.
The
method
LOQ
is
0.05
ppm
for
residues
in
meat,
poultry,
and
eggs
and
0.02
ppm
for
residues
in
milk.
Samples
from
the
ruminant
and
poultry
feeding
studies
were
analyzed
using
method
AG­
359
(
an
early
version
of
method
AG­
517)
and
method
AG­
517.
For
enforcement
purpose,
the
Multiresidue
Methods
Section
302
(
Luke
Method;
Protocol
D)
picks
up
parent
propiconazole.

GLN
860.1360:
Multiresidue
Methods
The
reregistration
requirements
for
multiresidue
method
testing
for
residues
of
propiconazole
and
its
metabolites
are
satisfied.
The
10/
99
FDA
PESTDATA
database
(
PAM
Volume
I,
Appendix
I)
indicates
that
propiconazole
is
completely
recovered
(>
80%)
using
Multiresidue
Methods
Section
302
(
Luke
Method;
Protocol
D).
The
recovery
of
propiconazole
metabolites
CGA­
91305,
CGA­
118244,
and
1,2,4­
triazole
is
variable
using
Section
302.
Propiconazole
and
metabolites
CGA­
91305,
CGA­
118244,
and
1,2,4­
triazole
are
not
recovered
using
Multiresidue
Methods
Sections
303
(
Mills,
Onley,
and
Gaither;
Protocol
E,
nonfatty)
and
304
(
Mills,
fatty
food).

GLN
860.1380:
Storage
Stability
Data
The
reregistration
requirements
for
storage
stability
data
are
satisfied.
Adequate
storage
stability
data
for
plant
and
animal
commodities
have
been
submitted
and
evaluated.
22
Plant
commodities:
Several
storage
stability
studies
have
been
submitted
and
evaluated.
These
studies
showed
that
fortified
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
DCBA
are
stable
under
frozen
storage
conditions
in/
on:
(
i)
peaches,
bananas,
corn
meal,
wheat
grain,
celery,
corn
oil,
and
peanut
nutmeat,
hay,
and
hulls
for
up
to
36
months
at
­
200C;
(
ii)
carrots
for
up
to
10
months
at
­
20
0C;
and
(
iii)
soybeans
and
soybean
fodder
for
up
to
4
and
6
months,
respectively,
at
­
15
0C.
Weathered
residues
of
propiconazole
and
metabolites
were
found
to
be
stable
under
frozen
storage
conditions
in/
on:
(
i)
grass
forage,
straw,
and
seed
for
up
to
39
months
at
­
20
0C;
(
ii)
wild
rice
and
stone
fruits
for
up
to
25
months
frozen
(
temperature
unspecified);
(
iii)
peanut
shells
and
fodder
for
25
months
at
­
15
0C;
and
(
iv)
extracts
of
silagestage
corn
forage
and
soybeans
for
3
and
8
months,
respectively,
at
4
C.
These
storage
stability
data
are
adequate
to
validate
the
storage
intervals
and
conditions
of
samples
collected
from
field
and
processing
studies.

Animal
commodities:
In
response
to
the
Propiconazole
Phase
4
Review,
data
were
submitted
showing
no
degradation
of
residues
in
propiconazole
in
animal
commodities
following
storage
for
four
years.
Data
submitted
in
support
of
the
goat
and
hen
metabolism
studies
demonstrated
that
residues
of
propiconazole
were
stable
in
the
following
frozen
matrices:
goat
urine
for
~
7
months,
goat
tissues
for
up
to
11
months,
and
extracts
of
egg
whites,
yolks,
and
poultry
muscle
for
up
to
6
months.
These
data
are
adequate
to
validate
the
storage
intervals
of
animal
commodity
samples
collected
from
the
feeding
studies.

GLN
860.1500:
Crop
Field
Trials
The
reregistration
requirements
for
magnitude
of
the
residue
in/
on
the
following
raw
agricultural
commodities
(
RACs),
based
on
the
currently
registered
use
patterns,
will
be
fulfilled
pending
label
revisions
and/
or
tolerance
adjustments:
barley,
rye,
rice,
wheat,
sweet
corn;
field
and
pop
corn,
oat,
peanut,
pineapple,
stone
fruits,
and
aspirated
grain
fractions.
We
note
that
the
submitted
field
trial
data
for
sugarcane
indicate
that
treatment
of
sugarcane
seed
pieces
according
to
the
currently
registered
use
pattern
can
be
considered
a
non­
food
use.

Overall,
adequate
field
trial
data
depicting
propiconazole
residues
of
concern
following
treatments
according
to
the
maximum
registered
use
patterns
of
the
representative
formulations
that
are
being
supported
have
been
submitted
for
the
RACs
listed
above,
or
have
been
translated
where
appropriate.
The
available
crop
field
trials
reflecting
use
of
registered
formulations
at
1x
the
maximum
label
rate
showed
finite
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
DCBA
and
expressed
as
parent
in/
on
the
RACs
of
all
crops
for
which
registration
exists
except
for
mushrooms,
pecans,
and
sugarcane;
residues
concentrated
10.4x
in
wheat
aspirated
grain
fractions.
Details
of
any
required
label
amendments
are
presented
in
the
endnotes
for
GLN
860.1200
(
Directions
for
Use)
and
respective
crop
sections
for
GLN
860.1500
(
Crop
Field
Trials)
of
Table
B.
Refer
to
"
Tolerance
Reassessment
Summary"
section
for
recommendations
with
respect
to
established
tolerance
levels.
23
Residue
data
for
uses
of
Stratego
 
Twin­
Pak
 
and
Stratego
 
Fungicide
formulations
on
wheat
have
been
submitted
and
reviewed
(
HED
memo
of
02/
02/
05,
Y.
Donovan,
D271790).
These
data
support
Section
3
registration
of
propiconazole
use
on
wheat
with
the
use
pattern
of
0.08
lbs
­
0.11
lbs
ai/
A/
application,
maximum
of
two
applications
per
growing
season,
and
with
35­
day
PHI
(
covers
Stratego
 
Twin­
Pak
 
and
Stratego
 
Fungicide
formulations
on
wheat).
The
residue
data
also
covers
all
24
C
wheat
use
patterns.
These
uses
have
higher
maximum
seasonal
rate
compared
to
currently
registered
propiconazole
formulations
(
maximum
single
application
of
0.11
lb
ai/
A,
maximum
of
one
application
per
growing
season,
PHI
40
days).
Therefore,
for
the
purpose
of
reregistration,
the
wheat
RAC
tolerances
should
be
reassessed
using
data
from
the
current
submission.
Based
on
the
cited
field
trials
associated
with
Stratego
 
Twin­
Pak
 
and
Stratego
 
uses,
HED
recommends
increasing
the
wheat
grain
tolerance
to
0.3
ppm,
wheat
straw
to
15.0
ppm,
and
to
propose
new
tolerances
on
wheat
hay
and
forage
at
2.0
ppm.

As
mentioned
under
Directions
for
Use,
Stratego
 
Twin­
Pak
 
and
Stratego
 
Fungicide
(
EPA
Reg.
Nos.
264­
779
)
have
been
registered
for
uses
on
corn,
peanuts,
pecans,
rice,
and
wheat
based
on
reviews
of
trifloxystrobin.
After
comparing
the
use
rates
of
Stratego
 
Twin­
Pak
 
and
Stratego
 
on
corn,
peanuts,
pecans
and
rice
to
the
use
rates
which
current
tolerances
on
corn,
peanuts,
pecans
and
rice
are
based
on,
HED
concludes
that
except
for
wheat,
the
rest
of
crops
have
lower
use
rates
on
Stratego
 
label
than
the
propiconazole
application
rates
used
in
the
crop
field
trials
used
to
set
the
original
tolerances.
HED
concludes
that
the
current
tolerances
support
the
Stratego
 
label.

The
Agency
now
recommends
that
wheat
hay
data
be
translated
to
oats
to
establish
a
more
appropriate
level
for
the
oat
hay
tolerance
at
2.0
ppm.

HED
is
translating
the
wheat
grain,
wheat
straw,
wheat
hay
and
forage
data
to
barley
and
rye
grain,
straw,
hay
and
forage.
Therefore,
no
further
data
requirements
are
needed.
The
reassessed
tolerances
for
barley
grain
and
rye
grain
should
be
0.3
ppm,
for
barley
and
rye
straw
should
be
15.0
ppm.
New
tolerances
for
barley
hay
and
rye
forage
should
be
established
at
2.0
ppm.

The
available
rice
residue
data
support
the
established
3.0
ppm
tolerance
for
propiconazole
residues
in/
on
rice
straw;
however,
the
data
also
indicate
that
the
registrant
should
propose
new
tolerance
for
residues
in/
on
rice
grain.
An
appropriate
level
for
residues
in/
on
rice
grain
would
be
0.3
ppm
(
HED
memo
of
02/
23/
05,
T.
Morton,
D240856).

A
Section
18
risk
assessment
has
been
conducted
by
RD
(
S18
request
from
the
States
of
Minnesota
and
South
Dakota
for
use
of
propiconazole
on
soybeans
to
control
soybean
rust).
It
was
recommended
that
time­
limited
tolerances
of
0.5
ppm
in/
on
soybeans,
8
ppm
in/
on
soybean
forage,
and
25
ppm
in
soybean
hay
be
established
(
Agency
memo
of
04/
14/
04,
J.
R.
Tomerlin,
D262299).
24
A
Section
18
risk
assessment
has
been
conducted
by
RD
(
S18
request
from
the
States
of
Maine
for
use
of
propiconazole
on
blueberry).
It
was
recommended
that
time­
limited
tolerances
of
1.0
ppm
in/
on
blueberry
be
established.
(
Agency
memo
of
02/
22/
05,
D.
Rate,
D313289).

Among
all
the
24C
requested
uses,
the
only
tolerances
required
to
be
reassessed
are
mint,
corn,
sunflower,
and
banana.
The
rest
can
be
considered
non­
food
uses.
The
use
on
sugarcane
seed
pieces
is
considered
non­
food
due
to
the
fact
that
it
takes
18
months
from
planting
to
harvesting
of
sugar
canes
(
conversation
with
Bernie
Schneider,
02/
03/
05).
The
use
on
sunflower
for
seeds
can
not
be
considered
non­
food
use,
and
therefore,
no
tolerance
can
be
established
on
sunflower
until
field
trial
data
are
submitted.
Field
trial
data
for
bananas
were
generated
in
Honduras,
Republic
of
Ivory
Coast,
Martinique,
and
Belize.
With
one
exception,
residues
did
not
exceed
the
tolerance
following
1­
13
aerial
or
ground
applications
of
a
250EC
formulation
at
41
g
ai/
A/
application
(=
0.90
lbs
ai/
A/
application).
The
only
registered
uses
are
in
Hawaii
and
Puerto
Rico(
24C),
with
the
rate
of
0.084
lbs
ai/
A/
application
and
maximum
8
applications.
HED
concludes
that
the
existing
tolerance
on
banana
is
adequate
GLN
860.1520:
Processed
Food/
Feed
The
reregistration
requirements
for
magnitude
of
the
residue
in
the
processed
commodities
of
the
following
crops
have
been
fulfilled:
barley,
corn,
mint,
oats,
peanut,
plums,
rye,
and
wheat.
The
available
data
indicate
that
residues
do
not
concentrate
significantly
in
corn
wet­
milled
and
drymilled
processed
fractions;
mint
oil;
rolled
oats,
hulls,
groats,
oat
flour,
fines,
light
impurities,
bran,
and
feed
oats;
peanut
meal,
soapstock,
crude
and
refined
oil,
and
peanut
presscake;
dried
prunes;
and
wheat
flour,
middlings,
shorts,
and
germ.

The
most
recent
wheat
processing
study
(
HED
memo
of
02/
02/
05,
Y.
Donovan,
D271790)
indicated
that
total
propiconazole
residues
do
not
concentrate
in
germ,
middlings,
low
grade
flour,
and
patent
flour
processed
from
whole
wheat
grains
bearing
either
nondetectable
(<
0.05
ppm)
or
measurable
residues,
and
therefore,
no
tolerances
are
needed
on
these
commodities.
The
average
concentration
factor
of
residues
in
wheat
bran
is
3.3x.
The
maximum
expected
residues
of
total
propiconazole
in
wheat
bran
is
0.99
ppm
which
is
determined
by
multiplying
the
average
concentration
factor
of
3.3x
with
the
highest
average
field
trial
(
HAFT)
residue
value
of
0.3
ppm.
A
tolerance
for
wheat
bran
at
1.0
ppm
is
needed.

A
new
rice
processing
study
has
been
submitted
and
reviewed
as
acceptable
by
the
Agency
(
MRID
45080811.
DER2),
the
review
indicated
that
the
concentration
factor
for
rice
bran
is
2.9x,
for
rice
hulls
is
3.8x,
and
for
polished
rice
is
0.12x.
The
registrant
needs
to
propose
new
tolerances
for
rice
bran
at
1.0
ppm
and
for
rice
hulls
at
1.2
ppm.

Aspirated
wheat
grain
fractions
25
Composition
of
AGF:
Corn
46%,
wheat
32%,
soybean
16%,
sorghum
6%
(
reference
from
ChemSAC
minute
05/
01/
02).

The
average
concentration
factor
of
residues
in
aspirated
wheat
grain
fraction
is
13.7x
from
the
new
submitted
processing
study
(
HED
memo
of
02/
02/
05,
Y.
Donovan,
D271790).
Based
on
the
field
trials,
the
proposed
tolerance
on
wheat
grain
is
0.3
ppm,
and
therefore,
the
maximum
AGF
residue
would
be
4.3
ppm.
The
maximum
expected
propiconazole
residues
in
soybean
aspirated
grain
fractions
would
be
3.5
ppm
(
memo
of
03/
10/
05,
T.
Morton,
D246884).
A
20
ppm
AFG
tolerance
was
established
on
barley
based
on
a
Section
18
use
on
barley,
which
is
based
on
the
tolerance
level
for
grain
sorghum
grain
(
0.2
ppm),
and
the
maximum
concentration
factor
of
100x.
This
Section
18
tolerance
will
expire
on
06/
30/
05.
No
data
are
yet
available
on
aspirated
grain
fractions
derived
from
corn
(
A
0.1
ppm
tolerance
on
corn
grain
has
been
established).
However,
HED
believes
that
residues
from
corn
AGF
will
not
likely
to
be
higher
than
that
from
wheat
based
on
the
fact
that
wheat
grain
has
higher
residues
than
corn
grain,
therefore,
HED
recommends
a
5.0
ppm
tolerance
on
aspirated
grain
fractions
for
propiconazole.

The
reregistration
requirements
for
magnitude
of
the
residue
in
the
processed
commodities
of
pineapple
have
not
been
fulfilled.
For
pineapple,
data
are
required
reflecting
the
potential
for
concentration
in
pineapple
juice.
Although
processing
data
are
now
required
for
pineapple
process
residue
instead
of
pineapple
fodder,
data
provided
with
the
original
tolerance
petition
confirmed
that
residues
were
non
detectable
(<
0.05
ppm)
in
pineapple
shells,
cores,
bran,
and
fodder.

Based
on
the
available
field
trial
data
for
sugarcane,
treatment
of
sugarcane
seed
pieces
according
to
the
currently
registered
use
pattern
can
be
considered
a
non­
food
use;
therefore,
there
are
no
requirements
for
magnitude
of
the
residue
in
processed
sugarcane
commodities.

GLN
860.1480:
Meat,
Milk,
Poultry,
Eggs
The
reregistration
requirements
for
data
depicting
the
magnitude
of
propiconazole
residues
of
concern
in
meat,
milk,
poultry,
and
eggs
have
been
fulfilled.
Acceptable
ruminant
and
poultry
feeding
studies
were
submitted
and
evaluated
in
conjunction
with
previous
propiconazole
petitions
(
PP#
4F3074
and
PP#
1F3974).
Because
of
the
addition
of
a
number
of
registered
uses
and
corresponding
tolerances
for
crops
with
animal
feed
items
since
the
Phase
4
Review,
including
grasses
grown
for
seed,
peanuts,
and
wheat
(
increased
use
rate),
the
maximum
theoretical
dietary
burden
to
livestock
has
been
recalculated
and
is
presented
below.
26
Calculation
of
maximum
livestock
dietary
burden
for
propiconazole.

Feed
Commodity
Reassessed
Tolerance
(
ppm)
%
Dry
Matter
%
of
Diet
Burden
(
ppm)

Beef
cattle
Grass,
hay
40
88
60
27.3
Aspirated
grain
fraction
5.0
85
20
1.2
Corn,
field,
grain
0.1
88
20
0.03
TOTAL
100
28.53
Dairy
cattle
Grass,
hay
40
88
60
27.3
Aspirated
grain
fraction
5.0
85
20
1.2
Corn,
field,
grain
0.1
88
20
0.03
TOTAL
100
28.53
Poultry
Corn,
field,
grain
0.1
88
80
0.08
Peanut,
meal
0.2
89
20
0.04
TOTAL
80
0.12
Swine
Peanut,
meal
0.2
85
15
0.03
Wheat,
grain
0.1
89
80
0.08
TOTAL
95
0.11
The
results
of
the
livestock
feeding
studies
are
summarized
below.

In
the
ruminant
feeding
study,
cattle
were
fed
propiconazole
at
dose
levels
of
15,
75,
and
150
ppm
for
periods
of
14,
21,
or
28
days.
These
dose
levels
represent
0.54x,
2.6x,
and
5.2x
the
maximum
theoretical
dietary
burden
to
dairy
cattle.
Milk
samples
were
collected
daily.
The
results
of
the
study
are
summarized
in
the
table
below.

Residues
of
propiconazole
and
metabolites
in
tissues
of
dairy
cows
fed
propiconazole
at
dose
levels
of
15,
75,
and
150
ppm.

Feeding
level
(
ppm)

14
days
21
days
28
days
Matrix
15
75
150
15
75
150
15
75
150
Muscle
<
0.05
0.11
0.18
<
0.05
0.08
0.13
<
0.05
0.05
0.11
Kidney
0.61
3.04
6.48
0.56
4.68
5.0
0.63
3.68
5.5
Liver
0.5
4.0
4.6
0.81
4.3
5.3
0.57
2.7
5.6
27
Fat
<
0.05
0.23
0.26
<
0.05
0.15
0.19
<
0.05
0.08
0.17
In
milk,
residues
were
nondetectable
(<
0.01
ppm)
at
the
15­
ppm
feeding
level,
and
maximum
residues
of
0.1
ppm
and
0.11
ppm
were
detected
at
the
75­
and
150­
ppm
feeding
levels,
respectively.
These
results
indicate
that
tolerances
for
propiconazole
residues
of
concern
in
ruminant
commodities
are
necessary.
The
appropriate
levels
for
these
tolerances
are
addressed
in
the
Tolerance
Reassessment
Summary.

In
the
poultry
feeding
study,
laying
hens
were
fed
propiconazole
at
dose
levels
of
7.5,
37.5,
and
75
ppm
for
periods
of
14,
21,
or
28
days.
These
dose
levels
represent
63x,
310x,
and
630x
the
maximum
theoretical
dietary
burden
to
dairy
cattle.
Egg
samples
were
collected
daily.
The
results
of
the
study
are
summarized
in
the
table
below.

Residues
of
propiconazole
and
metabolites
in
tissues
of
laying
hens
fed
propiconazole
at
dose
levels
of
7.5,
37.5,
and
75
ppm.

Feeding
level
(
ppm)

14
days
21
days
28
days
Matrix
7.5
37.5
75
7.5
37.5
75
7.5
37.5
75
Muscle
<
0.05
­­
­­
<
0.05
<
0.05
0.07
<
0.05
<
0.05
0.06
Liver
<
0.1
0.1
0.47
­­
0.08
0.39
<
0.1
0.16
0.3
Fat
­­
<
0.05
0.11
­­
<
0.05
0.06
­­
<
0.05
0.05
In
eggs,
residues
were
nondetectable
(<
0.05
ppm)
at
the
7.5­
ppm
feeding
level,
and
maximum
residues
of
0.18
ppm
and
0.37
ppm
were
detected
at
the
37.5­
and
75­
ppm
feeding
levels,
respectively.
These
results
indicate
that
propiconazole
residues
of
concern
are
nondetectable
in
eggs,
muscle,
and
liver
at
a
feeding
level
corresponding
to
63x
the
maximum
dietary
burden,
and
in
fat
at
a
feeding
level
corresponding
to
310x
the
maximum
dietary
burden.
Therefore,
propiconazole
can
be
classified
as
Category
3
of
180.6(
a)
with
respect
to
the
need
for
tolerances
in
eggs
and
poultry
tissues.
Tolerances
for
poultry
commodities
are
not
required.
(
Also
see
HED
memo
fo
03/
06/
02,
Bonnie
Cropp­
Kohlligian,
D281520).
28
GLN
860.1400:
Water,
Fish,
and
Irrigated
Crops
Propiconazole
is
presently
not
registered
for
direct
use
on
water
and
aquatic
food
and
feed
crops.
Although
propiconazole
is
registered
for
use
on
rice,
current
label
restrictions
prohibit
the
use
on
rice
in
CA
(
where
typical
agricultural
practices
for
rice
field
irrigation
entail
a
"
flow­
through"
system);
typical
agricultural
practices
concerning
rice
field
irrigation
in
all
other
areas
allow
for
the
on­
site
evaporation
of
waters
used
in
rice
fields.
Label
restrictions
preclude
the
use
of
water
drained
from
treated
rice
fields
to
irrigate
other
crops.
Label
restrictions
also
preclude
use
where
catfish
and
crayfish
are
produced.
Therefore,
no
residue
chemistry
data
are
required
under
these
guideline
topics.

GLN
860.1460:
Food
Handling
Propiconazole
is
presently
not
registered
for
use
in
food­
handling
establishments;
therefore,
no
residue
chemistry
data
are
required
under
this
guideline
topic.

GLN
860.1850
and
860.1900:
Confined/
Field
Accumulation
in
Rotational
Crops
The
nature
of
the
residue
in
confined
rotational
crops
is
understood,
and
no
additional
confined
rotational
crop
data
are
required
for
the
purpose
of
reregistration.
Based
on
acceptable
studies
reviewed
by
EFED,
the
metabolism
of
propiconazole
in
rotational
crops
is
similar
to
that
in
primary
crops.

Plantback
restrictions
have
been
established
for
propiconazole
products
registered
for
use
on
rotatable
crops
based
on
the
confined
rotational
crop
studies.
Labels
for
these
formulations
specify
that
soybeans
may
be
planted
as
a
double
crop
following
a
cereal
crop
which
has
been
treated
with
the
product,
but
soybean
hay,
forage,
and
fodder
may
not
be
used
as
any
component
of
animal
feed
or
bedding.
The
labels
specify
that
any
food/
feed
crops
not
listed
on
the
label
should
not
be
planted
within
105
days
of
treatment.

Recent
data
are
also
available
depicting
propiconazole
residue
in
rotational
lentils
and
peas
to
satisfy
requirements
for
field
rotational
crop
trial
data
for
potential
uses
in
the
Pacific
Northwest.
Residues
of
propiconazole
were
<
LOQ
(
0.05
ppm)
in/
on
all
matrices
harvested
from
rotational
legume
crops
planted
329­
376
days
posttreatment.
Additional
field
rotational
crop
data
would
be
required
to
revise
the
established
plantback
intervals.

A
petition
is
pending
for
tolerances
on
the
rotational
crops
alfalfa
and
sorghum
(
PP#
5F4498).
This
petition
has
not
been
reviewed.
29
Table
B.
Residue
Chemistry
Science
Assessments
for
Reregistration
of
Propiconazole.
GLN:
Data
Requirements
Current
Tolerances,
ppm
[
40
CFR]
Must
Additional
Data
Be
Submitted?
References
1
860.1200:
Directions
for
Use
Not
applicable
(
N/
A)
Yes
2
See
Tables
A1
and
A2
860.1300:
Plant
Metabolism
N/
A
No
00074496
3,
00074498
,
00074499
,
00074500
,
00074501
,
00074502
,
00129915
,
00155645
,
44049601
4,
44381402
5,
93194062
860.1300:
Animal
Metabolism
N/
A
No
6
PP#
8F3674
7,
00067905
,
00074503
,
00074504
,
41823301
8,
41823302
,
41823304
,
42564006
9,
42983001
10,
93194085
860.1340:
Residue
Analytical
Methods
­
Plant
commodities
N/
A
No
11
00137150
12,
40154501
13,
40180701
14,
40692203
15,
40692204
,
40692206
,
40783306
16,
41063801
17,
41063802
,
41486801
18,
41823305
,
42061301
19,
42182901
20,
42564005
,
42605801
21,
42634101
22,
43424601
23,
43434201
24,
43825401
25,
44411201
26,
44411206
,
44411207
,
44411208
,
93194064
­
Animal
commodities
N/
A
No
40150701
27,
40154501
,
40180702
,
41823304
,
44411204
,
93194067
860.1360:
Multiresidue
Methods
N/
A
No
40100101
28,
93194066
860.1380:
Storage
Stability
Data
­
Plant/
processed
commodities
N/
A
No
00074510
,
00074511
,
00133385,
40692201
,
41063801
,
41063802
,
41486802
,
42605801
,
43314201
29,
43825402
,
44411205
,
93194068
­
Animal
commodities
N/
A
No
30
40150701
,
42983001
860.1500:
Crop
Field
Trials
Leafy
Vegetables
(
Except
Brassica
Vegetables)
Group
­
Celery
5.0
[
§
180.434(
a)]
No
40783301
,
41486801
Table
B
(
continued).

30
Legume
Vegetables
Group
­
Bean,
dry
0.5
[
§
180.434(
b)]
No
31
Foliage
of
Legume
Vegetables
Group
­
Bean,
dry,
forage
and
hay
8.0,
forage
8.0,
hay
[
§
180.434(
b)]
No
Stone
Fruits
Group
1.0
[
§
180.434(
a)]
No
32
­
Apricots
1.0
[
§
180.434(
a)]
No
41063802
­
Cherries
Group
tolerance
established
No
43655609
­
Nectarines
1.0
[
§
180.434(
a)]
No
41063802
­
Peaches
1.0
[
§
180.434(
a)]
No
41063802
­
Plums
1.0
[
§
180.434(
a)]
No
41063802
­
Prunes,
fresh
1.0
[
§
180.434(
a)]
No
41063802
Berries
Group
­
Blueberries
1.0
[
§
180.434(
b)]
No
33
­
Raspberries
1.0
[
§
180.434(
b)]
No
Tree
Nuts
Group
­
Almonds,
nutmeat
and
hulls
0.1,
nutmeat
2.5,
hulls
[
§
180.434(
b)]
No
34
­
Pecans
0.1
[
§
180.434(
a)]
No
35
00074495
,
00074508
,
00074509
,
00153327
Cereal
Grains
Group
­
Barley,
grain
0.1
[
§
180.434(
a)]
No
36
PP#
4F3074
37,
93194072
Table
B
(
continued).

31
­
Corn,
field,
grain
and
aspirated
grain
fractions
0.1,
grain
[
§
180.434(
a)]
No
38
40783303
,
42564004
,
42564005
­
Corn,
pop
0.1,
grain
[
§
180.434(
a)]
No
39
­
Corn,
sweet
(
kernels
plus
cobs
with
husks
removed)
0.1
[
§
180.434(
a)]
No
40783303
,
42564004
,
42564005
­
Oats,
grain
0.1
[
§
180.434(
a)]
No
42182901
,
43314202
­
Rice,
grain
0.1
[
§
180.434(
a)]
No
40
00137861
,
42915601
41,
44411208
,
93194075
­
Rye,
grain
0.1
[
§
180.434(
a)]
No
­
Sorghum,
grain
and
aspirated
grain
fractions
0.2,
grain
20,
AGF
[
§
180.434(
b)]
No
42
­
Wheat,
grain
and
aspirated
grain
fractions
0.1,
grain
[
§
180.434(
a)]
No
43
PP#
4F3074
,
44411206
,
44411207
,
93194072
­
Wild
rice
0.5
[
§
180.434(
c)]
No
41063801
,
42511401
44
Fodder,
Forage,
Hay,
and
Straw
of
Cereal
Grains
Group
­
Barley,
hay
and
straw
1.5,
straw
[
§
180.434(
a)]
No
,
45
PP#
4F3074
,
93194072
­
Corn,
field,
forage
and
stover
12,
fodder
and
forage
[
§
180.434(
a)]
No
40783303
,
42564004
,
42564005
­
Corn,
pop,
stover
12,
fodder
[
§
180.434(
a)]
No
­
Corn,
sweet,
forage
and
stover
12,
fodder
and
forage
[
§
180.434(
a)]
No
40783303
,
42564004
,
42564005
Table
B
(
continued).

32
­
Oats,
forage,
hay,
and
straw
10.0,
forage
30.0,
hay
1.0,
straw
[
§
180.434(
a)]
No
46
42182901
,
43314202
­
Rice,
straw
3.0
[
§
180.434(
a)]
No
00137861
,
44411208
,
93194075
­
Rye,
forage
and
straw
1.5,
straw
[
§
180.434(
a)]
No
,

­
Sorghum,
stover
1.5
[
§
180.434(
b)]
No
­
Wheat,
forage,
hay,
and
straw
1.5,
straw
[
§
180.434(
a)]
No
47
PP#
4F3074
,
44411206
,
4441207
,
93194072
Grass
Forage,
Fodder,
and
Hay
Group
­
Grass,
seed
screenings,
forage,
hay,
and
straw
60,
seed
screenings
0.5,
forage
40,
hay
(
straw)
[
§
180.434(
a)]
No
48
40890701,
41823305
,
42634101
,
42634102
,
93194073
Miscellaneous
Commodities
­
Bananas
0.2
[
§
180.434(
a)]
No
49
00137150
,
93194071
­
Cranberries
1.0
[
§
180.434(
b)]
No
­
Mint
0.3
[
§
180.434(
c)]
No
50
42061301
,
43424601
­
Mushrooms
0.1
[
§
180.434(
a)]
No
51
43434201
­
Peanut,
nutmeat
and
hay
0.2,
peanut
20.0,
hay
[
§
180.434(
a)]
No
52
40692201
Table
B
(
continued).

33
­
Pineapple
0.1,
pineapple
and
fodder
[
§
180.434(
a)]
No
40783305
­
Sugarcane
None
established
No
53
44142401
,
93194077
­
Sunflower
Breeder's
Seed
None
established
Yes
54
860.1520:
Processed
Food/
Feed
­
Barley
None
established
No
55
­
Corn,
field
None
established
No
40783303
,
42564005
­
Mint
None
established
No
42061301
,
43424601
­
Oat
None
established
No
42182901
­
Peanut
None
established
No
40692201
,
42605801
­
Pineapple
None
established
Yes
56
40783305
­
Plum
None
established
No
41063802
­
Rice
None
established
No
57
00137861
,
42915601,
93194079
­
Rye
None
established
No
­
Sorghum
None
established
No
58
­
Sugarcane
None
established
No
Table
B
(
continued).

34
­
Wheat
None
established
No
PP#
4F3074
,
44411206
,
44411207
,
44757208,
93194080
860.1480:
Meat,
Milk,
Poultry,
Eggs
­
Milk
and
the
Fat,
Meat,
and
Meat
Byproducts
of
Cattle,
Goats,
Hogs,
Horses,
and
Sheep
0.05,
milk;
0.1,
fat,
meat,
and
mbyp;
2.0,
kidney
and
liver
[
§
180.434(
a)]
No
00137861
,
40150701
,
93194070
­
Eggs
and
the
Fat,
Meat,
and
Meat
Byproducts
of
Poultry
0.1,
eggs,
fat,
meat,
and
mbyp;
0.2,
kidney
and
liver
[
§
180.434(
a)]
No
00137861
,
40150701
,
93194070
860.1400:
Water,
Fish,
and
Irrigated
Crops
N/
A
N/
A
860.1460:
Food
Handling
N/
A
N/
A
860.1650
Submittal
of
Analytical
Reference
Standards
Yes
See
foot
note
64
860.1850:
Confined
Rotational
Crops
N/
A
No
59
00074498,
00129915
60,
00138266,
00155644
61
00155645,
00164802
,
62,
41102001
63
860.1900:
Field
Rotational
Crops
None
established
No
64
44411206
1.
Bolded
references
were
evaluated
in
the
Propiconazole
Phase
4
Review
dated
6/
25/
92,
by
B.
Cropp­
Kohlligian,
F.
Fort,
and
F.
Toghrol;
because
a
number
of
the
references
cited
in
the
Phase
4
Review
were
reviewed
in
connection
with
petitions
for
uses
which
have
since
been
registered,
in
some
cases
the
original
review
documents
are
noted
as
well.
All
other
references
were
reviewed
as
noted.

2.
Syngenta
is
required
to
amend
the
product
labels
for
the
41.8%
EC
formulations
(
100­
617
and
100­
737)
to
indicate
the
propiconazole
concentration
in
terms
of
lb
ai/
gal.
In
addition,
label
restrictions
which
prohibit
the
feeding
of
treated
forage
and/
or
hay
of
cereals
and
corn
to
livestock
must
be
removed
from
the
41.8%
EC
(
100­
617
and
100­
737)
and
the
45%
WP
(
100­
780)
formulations.
The
use
directions
for
rice
on
all
labels
should
be
amended
to
specify
a
45­
day
PHI.
HED
notice
that
the
maximum
number
of
applications
for
peanuts
on
Stratego
 
label
is
not
very
clear.
After
discussing
with
RD
and
the
registrant,
it
is
Table
B
(
continued).

35
understood
that
the
maximum
number
of
six
applications
is
intended
only
for
the
7.0
oz
ai/
A
rate,
where
the
restricted
number
of
application
at
14
oz
ai/
A
is
only
two.
HED
recommends
that
the
petitioner
to
amend
the
Stratego
 
label
to
specify
these
instructions.
Since
there
are
adequate
field
trial
data
to
support
Section
3
registration
of
propiconazole
uses
on
wheat
at
the
rate
of
0.08
­
0.11
lbs
ai/
A/
application,
maximum
2
applications,
and
35
day
PHI
(
HED
memo
of
02/
02/
05,
Y.
Donovan,
D271790),
HED
recommends
increasing
the
existing
tolerances
on
wheat
RAC
to
cover
Stratego
Fungicide
(
EPA
Reg.
No.
264­
779)
uses
on
wheat.
These
new
reassessed
tolerances
will
cover
all
24C
uses
on
wheat
as
well.
HED
recommends
to
cancel
all
24C
uses
while
revising
the
Section
3
label
to
include
these
24C
uses.

3.
PP#
4F3007on
pecans,
RCB#
711,
5/
15/
84,
A.
Smith.
4.
DP
Barcode
D233755,
9/
14/
99,
T.
Morton.
5.
DP
Barcode
D245249,
12/
14/
99,
T.
Morton.

6.
Although
the
Phase
4
Review
concluded
that
additional
animal
metabolism
data
were
required,
the
Agency
concluded,
based
on
the
registrant's
90­
day
response
to
the
DCI,
that
the
available
data
were
adequate
to
satisfy
data
requirements
(
CB#
13166,
DP
Barcode
D198815,
4/
26/
94,
F.
Fort).

7.
PP#
8F3674,
CB#
11976,
DP
Barcode
D191918,
9/
20/
93,
M.
Flood.
8.
PP#
1F3974
on
grass
seed
screenings,
CB
No.
7822,
6/
11/
91,
S.
Willett.
9.
PP#
8F3674
on
corn
and
pineapple,
CB#
10974,
D185251,
5/
6/
93,
M.
Flood.
10.
PP#
8F3674
on
corn
and
pineapple,
CB#
12839,
DP
Barcode
D196789,
3/
28/
94,
M.
Flood.

11.
In
the
Phase
4
Review,
the
registrant
was
required
to
conduct
enforcement
method
validation
for
Method
AG­
454A
using
bananas.
This
requirement
is
no
longer
needed.

12.
PP#
4F3026,
RCB#
826,
6/
20/
84,
K.
Arne.
13.
PP#
4F3074
on
small
grains,
CB
No.
2174,
5/
7/
87,
S.
Malak.
14.
PP#
4F3074
on
small
grains,
CB
No.
2262,
5/
15/
87,
S.
Malak.
15.
PP#
8F3654
on
peanuts,
CB
No.
4108,
11/
22/
88,
H.
Fonouni.
16.
PP#
8F3674
on
legumes,
CB
No.
4279,
12/
14/
88,
C.
Deyrup.
17.
PP#
9F3758
on
rice,
wild
rice,
stone
fruits,
CB
Nos.
5226­
5228,
11/
28/
89,
S.
Malak.
18.
PP#
0F3869
on
cherry,
CB
No.
6724,
8/
15/
90,
W.
Chin.
19.
PP#
2E4027
on
mint,
DP
Barcode
D170759,
2/
14/
92,
W.
Wassell.
20.
PP#
2F4086
on
oats,
CB#
9325,
DP
Barcodes
D174248
and
D175989,
7/
20/
93,
R.
Lascola.

21.
PP#
8F3674
on
peanuts,
CB#
12638,
DP
Barcodes
D186202,
D186203,
D186205,
D186206,
and
D195499,
11/
8/
93,
M.
Flood.

22.
PP#
1F3979
on
grass
grown
for
seed,
CB#
11304,
DP
Barcodes
D187417,
D190147,
and
D190263,
5/
12/
93,
M.
Flood.

23.
PP#
2E4037
on
mint
hay,
CB#
14711,
DP
Barcode
D209458,
4/
25/
95,
W.
Wassell.
24.
PP#
5E4437
on
mushroom,
CB#
14693,
DP
Barcode
D209195,
3/
29/
95,
W.
Cutchin
25.
DP
Barcode
D220935,
3/
25/
99,
T.
Morton.
26.
DP
Barcode
D240856,
02/
23/
05,
T.
Morton.
27.
PP#
4F3074
on
small
grain/
pecans,
CB
No.
2172,
5/
14/
87,
S.
Malak.
Table
B
(
continued).

36
28.
PP#
4F3074
on
small
grain/
pecans
CB
No.
2108,
4/
28/
87,
S.
Malak.
29.
PP#
2F4086
on
rice,
CB#
14941,
DP
Barcode
D210742,
3/
15/
95,
M.
Rodriguez.

30.
The
Phase
4
Review
concluded
that
additional
storage
stability
data
were
required
to
support
the
livestock
feeding
studies.
In
their
90­
day
response
to
the
DCI,
the
registrant
presented
data
to
satisfy
this
data
requirement
(
DP
Barcode
D198815,
4/
26/
94,
F.
Fort).

31.
Section
18
Exemption
with
associated
time­
limited
tolerance
on
dry
beans.
Use
of
propiconazole
on
dry
beans
has
been
proposed
under
pending
petition
PP#
5F4424
(
now
incorporated
into
PP#
2F6371).

32.
Establishment
of
a
stone
fruit
group
tolerance
was
approved
on
further
consideration
of
new
and
available
data
for
cherries
(
PP#
4F4321,
DP
Barcode
D217199,
8/
14/
95,
W.
Cutchin
and
DP
Barcode
D210252,
4/
25/
95,
W.
Cutchin).

33.
Section
18
Exemption
with
associated
time­
limited
tolerance
on
blueberry
in
Maine
(
Agency
memo
of
02/
22/
05,
D.
Rate,
D313289).
Use
of
propiconazole
on
the
berries
group
has
been
proposed
under
pending
petition
PP#
5F4591,
now
incorporated
into
PP#
2F6371.

34.
Section
18
Exemption
with
associated
time­
limited
tolerance
on
tree
nuts.
Use
of
propiconazole
on
tree
nuts
has
been
proposed
under
pending
petition
PP#
9F3470,
now
incorporated
into
PP#
2F6371.

35.
The
existing
tolerance
covers
the
registered
uses
of
propiconazole
on
pecans.
Syngenta
is
petitioning
for
a
tree
nut
group
tolerance
(
PP#
9F3740,
now
incorporated
into
PP#
2F6371),
which
will
be
handled
by
registration.

36.
The
available
data
pertaining
to
propiconazole
residues
of
concern
in/
on
wheat
grain
and
straw
supporting
the
currently
registered
maximum
use
pattern
(
D271790)
can
be
translated
to
barley
grain
and
straw
and
rye
grain
and
straw.

37.
PP#
4F3074,
RCB#
898,
7/
12/
84,
A.
Smith.

38.
PP#
8F3674
on
corn
and
pineapple,
03/
28/
94,
D196789,
M.
Flord.
The
new
submitted
storage
stability
data
are
adequate
and
indicate
that
propiconazole
is
stable
at
­
20

C
for
up
to
36
months
in
the
following
commodities:
peaches,
bananas,
corn
meal,
wheat
grain,
celery,
corn
oil,
and
peanut
nutmeat,
hay,
and
hulls.
Propiconazole
is
also
stable
in
carrots
for
up
to
10
months
at
­
20

C
(
Barcode
D240856).
Timelimited
tolerances
have
been
extended
to
12/
31/
00
pending
review
of
a
modified
mid­
dose
carcinogenicity
study
in
mice
(
64
FR
13086,
13105,
3/
17/
99).
HED
believes
that
residues
from
corn
AGF
will
not
likely
to
be
higher
than
that
from
wheat
based
on
the
fact
that
wheat
grain
has
higher
residues
than
corn
grain,
therefore,
HED
recommends
a
5.0
ppm
tolerance
on
aspirated
grain
fractions
for
propiconazole.

39.
The
available
data
pertaining
to
field
corn
commodities
may
be
translated
to
popcorn
commodities.

40.
The
product
labels
for
the
41.8%
ECs
(
EPA
Reg.
Nos.
100­
617
and
100­
737)
must
be
modified
to
specify
a
45­
day
PHI
for
rice.

41.
DP
Barcode
D195566,
11/
2/
93,
C.
Swartz;
preliminary
6
(
a)
(
2)
data
on
rice.
Table
B
(
continued).

37
42.
Section
18
Exemption
with
associated
time­
limited
tolerance
on
cranberries.
Use
of
propiconazole
has
been
proposed
by
IR­
4
under
pending
petition
PP#
7E4860.

43.
Data
supporting
the
currently
registered
maximum
use
pattern
(
MRID
44411207)
are
adequate.
The
product
labels
for
the
41.8%
ECs
(
EPA
Reg.
Nos.
100­
617
and
100­
737)
and
the
45%
WP
(
EPA
Reg.
No.
100­
780)
must
be
amended
to
specify
a
PHI
of
no
less
than
45
days
for
wheat
grain
and
straw.
The
registrant
submitted
data
reflecting
a
new
use
pattern
(
2x
the
current
use
pattern)
but
did
not
state
whether
they
wished
to
support
this
new
use
pattern.
If
the
registrant
desires
to
support
this
use
pattern,
then
additional
data
would
be
required
(
see
D240856)

44.
PP#
9F3758
on
wild
rice,
apricots,
nectarines,
peaches,
plums,
prunes.
DP
Barcode
D183633,
4/
8/
93,
M.
Rodriguez.

45.
Adequate
data
supporting
the
currently
registered
maximum
use
pattern
for
wheat
hay
and
forage
have
been
received
and
reviewed
(
HED
memo
of
02/
02/
05,
Y.
Donovan,
D271790).
They
can
be
translated
to
barley
hay
and
rye
forage.
The
product
labels
for
the
41.8%
EC
(
EPA
Reg.
Nos.
100­
617
and
100­
737)
and
the
45%
WP
(
EPA
Reg.
No.
100­
780)
formulations
must
be
modified
to
make
the
use
patterns
for
barley
and
rye
identical
to
wheat.

46.
Outstanding
deficiencies
pertaining
to
use
of
propiconazole
on
oats
(
PP#
2F04086)
have
been
resolved
by
proposal
of
a
tolerance
for
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
DCBA
in/
on
oat
hay
(
DP
Barcode
D218453,
8/
24/
95,
M.
Rodriguez).
Because
no
data
for
oat
hay
were
available,
the
appropriate
level
for
this
tolerance
was
calculated
from
data
for
oat
forage
using
a
3x
dry­
down
factor.
Currently,
data
for
wheat
hay
are
available,
and
these
data
can
be
translated
to
oats
to
determine
a
more
appropriate
level
for
the
oat
hay
tolerance.

47.
Adequate
data
on
wheat
have
been
submitted
and
reviewed
(
HED
memo
of
02/
02/
05,
Y.
Donovan,
D271790).
No
additional
data
are
needed.

48.
PP#
1F3974,
"
Propiconazole
(
Tilt)
in/
on
Grass
Grown
for
seed
Ciba­
Geigy
Amendment
dated
7/
2/
93".
M.
Flood,
9/
20/
93,
D192904.

49.
Banana
field
trial
data
were
generated
in
Honduras,
Republic
of
Ivory
Coast,
Martinique,
and
Belize.
With
one
exception,
residues
did
not
exceed
the
tolerance
following
1­
13
aerial
or
ground
applications
of
the
250EC
formulation
at
41
g
ai/
A/
application
(=
0.090lbs
ai/
A/
application).
The
only
registered
uses
are
in
Hawaii
and
Puerto
Rico,
with
the
rate
of
0.084
lbs
ai/
A/
application
and
maximum
8
applications.
HED
concludes
that
the
existing
tolerance
on
banana
is
adequate.

50.
Use
of
propiconazole
on
mint
is
currently
supported
by
IR­
4
and
is
registered
under
SLN
OR960007.
A
tolerance
was
established
in
connection
with
PP#
2E4037.

51.
Use
on
mushrooms
is
being
supported
by
IR­
4.
A
tolerance
was
established
in
connection
with
PP#
5E4437.

52.
CBTS
recommended
for
the
establishment
of
time­
limited
tolerances
for
peanut
commodities
Table
B
(
continued).

38
pending
receipt
of
additional
storage
stability
data
(
8F3654,
DP
Barcode
D197841,
1/
25/
94,
M.
Flood).
These
data
have
since
been
received
and
reviewed
(
DP
Barcode
D240856).

53.
The
available
data
indicate
that
treatment
of
sugarcane
pieces
according
to
the
currently
registered
use
pattern
can
be
considered
a
nonfood
use.

54.
The
available
data
indicate
that
treatment
of
sunflower
grown
for
seed
can
not
be
considered
a
nonfood
use.
Field
trial
data
on
sunflower
are
required
to
establish
tolerance.

55.
The
available
data
for
processed
wheat
commodities
may
be
translated
to
barley
and
rye.
(
HED
memo
of
02/
02/
05,
Y.
Donovan,
D271790).

56.
Data
must
be
submitted
depicting
the
potential
for
concentration
of
propiconazole
residues
of
concern
in
pineapple
juice.

57.
A
new
rice
processing
study
has
been
submitted
and
reviewed
by
the
Agency
as
acceptable
(
MRID45080811.
DER2).

58.
The
Agency
has
determined
that
adequate
data
pertaining
to
magnitude
of
the
residue
in
the
processed
commodities
of
sorghum
are
available
to
support
the
Section
18
Exemption.
A
tolerance
was
proposed
in
connection
with
PP#
5F4498.

59.
EFGWB
concluded
that
this
requirement
has
been
fulfilled
(
DP
Barcode
D166460,
11/
7/
91,
P.
Mastrodone).
60.
EFGWB
No.
70298,
3/
23/
87,
E.
Regelman.
61.
EFGWB
No.
70297,
5/
18/
87,
E.
Regelman.
62.
EFGWB
No.
70102,
12/
24/
86,
E.
Regelman.
63.
EFGWB
No.
90613,
10/
19/
89,
E.
Regelman.

64.
Additional
data
would
be
required
to
revise
the
plantback
intervals
currently
specified
on
labels
for
products
with
uses
on
rotatable
crops.
Data
are
available
depicting
propiconazole
residue
in
rotational
lentils
and
peas
to
satisfy
requirements
for
field
rotational
crop
trial
data
for
potential
uses
in
the
Pacific
Northwest.
Residues
of
propiconazole
were
<
LOQ
(
0.05
ppm)
in/
on
all
matrices
harvested
from
rotational
legume
crops
planted
329­
376
days
posttreatment.

65.
An
analytical
reference
standard
for
propiconazole
is
available
in
the
National
Pesticide
Standards
Repository.
Analytical
reference
standards
of
propiconazole
must
be
supplied
and
supplies
replenished
as
requested
by
the
Repository.
The
reference
standards
should
be
sent
to
the
Analytical
Chemistry
Lab,
which
is
located
at
Fort
Meade,
to
the
attention
of
either
Theresa
Cole
or
Frederic
Siegelman
at
the
following
address:
USEPA,
National
Pesticide
Standards
Repository/
Analytical
Chemistry
Branch/
OPP,
701
Mapes
Road,
Fort
George
G.
Meade,
MD
20755­
5350
(
Note
that
the
mail
will
be
returned
if
the
extended
zip
code
is
not
used.)
39
TOLERANCE
REASSESSMENT
SUMMARY
Tolerances
for
residues
in/
on
plant
and
animal
commodities
are
established
under
40
CFR
§
180.434.
They
are
currently
expressed
in
terms
of
the
combined
residues
of
propiconazole
(
1­
[[
2­(
2,4­
dichlorophenyl)­
4­
propyl­
1,3­
dioxolan­
2­
yl]
methyl]­
1H­
1,2,4­
triazole)
and
its
metabolites
determined
as
2,4­
dichlorobenzoic
acid
and
expressed
as
parent
compound.
HED
has
determined
that
the
current
tolerance
expressions
for
plant
and
animal
commodities
are
not
appropriate.
The
tolerance
expressions
should
be
revised
to
parent
per
se,
that
is,
propiconazole
(
1­[[
2­(
2,4­
dichlorophenyl)­
4­
propyl­
1,3­
dioxolan­
2­
yl]
methyl]­
1H­
1,2,4­
triazole).

The
Agency
has
recently
updated
the
list
of
raw
agricultural
and
processed
commodities
and
feedstuffs
derived
from
crops
(
Table
1,
OPPTS
GLN
860.1000).
As
a
result
of
changes
to
Table
1,
tolerances
are
now
required
for
RACs
which
have
been
added
to
Table
1.
Also,
some
commodity
definitions
must
be
corrected.
The
reassessments
of
tolerances
for
some
commodities
are
contingent
upon
the
implementation
of
requested
label
revision(
s).
A
summary
of
propiconazole
tolerance
reassessments
is
presented
in
Table
C.

Tolerances
Established
Under
40
CFR
§
180.434(
a)

Sufficient
field
trial
data
reflecting
the
maximum
label
use
pattern
are
available
to
reassess
the
established
tolerances
for
the
following
RACs
as
defined:
barley,
grain;
barley,
straw;
celery;
corn,
fodder;
corn,
forage;
corn,
grain;
corn,
sweet
(
kernels,
plus
cobs
with
husks
removed);
grass,
forage;
grass,
hay
(
straw);
mushrooms;
oats,
forage;
oats,
grain;
oats,
hay;
oats,
straw;
peanuts;
peanuts
hay;
pecans;
pineapple;
rice,
grain;
rice,
straw;
rye,
grain;
rye,
straw;
stonefruit
group;
wheat,
grain;
and
wheat,
straw.
Likewise,
acceptable
feeding
studies
for
ruminants
and
poultry
are
available
to
reassess
the
tolerances
for
the
following
animal
commodities:
milk,
eggs,
and
the
fat,
kidney,
liver,
meat
byproducts
(
except
kidney
and
liver),
and
meat
of
cattle,
goats,
hogs,
horses,
poultry,
and
sheep.

The
existing
tolerance
covers
the
registered
uses
of
propiconazole
on
pecans.
Syngenta
is
petitioning
for
a
tree
nut
group
tolerance
(
PP#
9F3740,
now
incorporated
into
PP#
2F6371),
which
will
be
handled
by
registration.

Field
trial
data
for
bananas
were
generated
in
Honduras,
Republic
of
Ivory
Coast,
Martinique,
and
Belize.
With
one
exception,
residues
did
not
exceed
the
tolerance
following
1­
13
aerial
or
ground
applications
of
a
250EC
formulation
at
41
g
ai/
A/
application
(=
0.90
lbs
ai/
A/
application).
The
only
registered
uses
are
in
Hawaii
and
Puerto
Rico(
24C),
with
the
rate
of
0.084
lbs
ai/
A/
application
and
maximum
8
applications.
HED
concludes
that
the
existing
tolerance
on
banana
is
adequate
The
established
tolerances
for
apricots,
nectarines,
peaches,
plums,
and
prunes
should
be
revoked
because
a
stone
fruit
group
tolerance
has
been
established.
The
established
tolerance
for
pineapple
40
fodder
should
be
revoked
because
this
commodity
is
no
longer
considered
a
significant
livestock
feed
item.

The
established
tolerances
for
RACs
listed
under
40
CFR
§
180.434(
a)
are
reassessed
at
the
same
levels
except
those
listed
for
barley,
rice,
rye,
and
wheat;
higher
tolerances
are
required
for
these
crops
to
reflect
the
results
of
recent
field
trials.

The
established
tolerances
for
cattle,
goat,
hog,
horse,
and
sheep
commodities
listed
under
40
CFR
§
180.434(
a)
are
reassessed
at
the
same
levels
as
well,
due
to
the
fact
that
HED
is
unable
to
separate
the
parent
residues
from
the
metabolites,
and
the
fact
that
there
are
several
pending
petitions
for
new
uses
which
will
likely
to
result
in
increasing
of
the
dietary
burden.

Tolerances
To
Be
Proposed
Under
40
CFR
§
180.434(
a)

Because
of
changes
to
Table
1
(
OPPTS
860.1000),
tolerances
for
barley
hay,
rye
forage,
and
wheat
forage
and
hay
must
be
proposed.
The
required
data
for
wheat
hay
and
forage
will
be
translated
to
barley
hay
and
rye
forage.
Because
the
tolerance
level
for
oat
hay
was
not
determined
from
residue
data
but
was
calculated
from
the
oat
forage
level
using
a
3x
dry­
down
factor,
the
required
data
for
wheat
hay
should
be
translated
to
oat
hay
to
provide
a
more
realistic
level
for
this
tolerance.
Based
on
the
cited
field
trials
with
Stratego
 
Twin­
Pak
 
and
Stratego
 
,
HED
proposes
new
tolerances
on
wheat
hay
and
forage
at
2.0
ppm.
The
Agency
now
recommends
that
wheat
hay
data
be
translated
to
oats
to
establish
a
more
appropriate
level
for
the
oat
hay
tolerance
at
2.0
ppm.

HED
is
translating
the
wheat
grain,
wheat
straw,
wheat
hay
and
forage
data
to
barley
and
rye
grain,
straw,
hay
and
forage.
Therefore,
the
reassessed
tolerances
for
barley
grain
and
rye
grain
should
be
0.3
ppm,
for
barley
and
rye
straw
should
be
15.0
ppm.
New
tolerances
for
barley
hay
and
rye
forage
should
be
established
at
2.0
ppm
The
most
recent
wheat
processing
study
(
HED
memo
of
02/
02/
05,
Y.
Donovan,
D271790)
indicated
that
the
maximum
expected
residues
of
total
propiconazole
in
wheat
bran
is
0.99
ppm
which
is
determined
by
multiplying
the
average
concentration
factor
of
3.3x
with
the
highest
average
field
trial
(
HAFT)
residue
value
of
0.3
ppm.
A
tolerance
for
wheat
bran
at
1.0
ppm
is
needed.

The
average
concentration
factor
of
residues
in
aspirated
wheat
grain
fraction
is
13.7x
from
the
new
submitted
processing
study
(
HED
memo
of
02/
02/
05,
Y.
Donovan,
D271790).
Based
on
the
field
trials,
the
proposed
tolerance
on
wheat
grain
is
0.3
ppm,
and
therefore,
the
maximum
AGF
residue
would
be
4.3
ppm.
The
maximum
expected
propiconazole
residues
in
soybean
aspirated
grain
fractions
would
be
3.5
ppm
(
memo
of
03/
10/
05,
T.
Morton,
D246884).
A
20
ppm
AFG
tolerance
was
established
on
barley
based
on
a
Section
18
use
on
barley,
which
is
based
on
the
tolerance
level
for
grain
sorghum
grain
(
0.2
ppm),
and
the
maximum
concentration
factor
of
100x.
This
Section
18
tolerance
will
expire
on
06/
30/
05.
No
data
are
yet
available
on
aspirated
grain
41
fractions
derived
from
corn
(
A
0.1
ppm
tolerance
on
corn
grain
has
been
established).
However,
HED
believes
that
residues
from
corn
AGF
will
not
likely
to
be
higher
than
that
from
wheat
based
on
the
fact
that
wheat
grain
has
higher
residues
than
corn
grain,
therefore,
HED
recommends
a
5.0
ppm
tolerance
on
aspirated
grain
fractions
for
propiconazole.

The
commodity
definitions
for
corn
RAC
tolerances
are
currently
expressed
as
corn
per
se.
When
the
definition
is
revised
to
"
corn,
field",
tolerances
for
popcorn
grain
and
stover,
expressed
in
terms
of
"
corn,
pop",
will
need
to
be
established
at
levels
of
0.1
ppm
and
12
ppm,
respectively.
In
addition,
tolerances
for
"
corn,
sweet,
forage"
and
"
corn,
sweet,
stover"
will
need
to
be
established
at
12
ppm.

A
new
rice
processing
study
has
been
submitted
and
reviewed
as
acceptable
by
the
Agency
(
MRID
45080811.
DER2),
the
review
indicated
that
the
concentration
factor
for
rice
bran
is
2.9x,
for
rice
hulls
is
3.8x,
and
for
polished
rice
is
0.12x.
The
registrant
needs
to
propose
new
tolerances
for
rice
bran
at
1.0
ppm
and
for
rice
hulls
at
1.2
ppm.

Additional
data
have
also
been
required
for
pineapple
juice.

HED
notice
that
due
to
the
change
of
tolerance
expression
from
parent
plus
all
its
metabolites
containing
the
2,4­
dichlorophenyl
moiety
(
2,4­
DCBA)
to
parent
only,
in
some
cases
the
tolerance
levels
will
be
over
estimated.
Since
all
field
data
were
reported
as
propiconazole
and
all
its
metabolites
containing
the
2,4­
dichlorophenyl
moiety
(
2,4­
DCBA),
due
to
the
fact
that
the
analytical/
data
collection
method
is
a
moiety
method
that
detects
all
residues
convertible
to
2,4­
dichlorobenzoic
acid
(
DCBA),
HED
is
unable
to
separate
out
the
parent
residue
from
the
metabolites
at
this
time.
HED
recommends
that
the
registrant
analyze
parent
and
metabolites
separately
in
all
field
trials
so
that
more
realistic
tolerances
can
be
set
in
the
future.

Time­
Limited
Tolerances
Established
Under
40
CFR
§
180.434(
b)

Time­
limited
tolerances,
due
to
expire
12/
31/
05,
are
established
for
cranberry,
dry
bean
forage,
dry
bean
hay,
and
dry
beans.
In
addition,
time­
limited
tolerances,
due
to
expire
06/
30/
05,
are
established
for
aspirated
grain
fractions
(
20
ppm),
sorghum
grain,
and
stover
[
40
CFR
§
180.434(
b)].
Time­
limited
tolerances
are
being
recommended
by
RD
to
established
in/
on
soybeans
at
0.5
ppm,
in/
on
soybean
forage
at
8
ppm,
and
in
soybean
hay
at
25
ppm,
in/
on
blueberry
at
1.0
ppm.

Tolerances
with
Regional
Registrations
Established
Under
40
CFR
§
180.434(
c)

Tolerances
with
regional
registrations
have
been
established
for
the
following
RACs
as
defined:
mint,
tops
(
leaves
and
stems)
and
wild
rice.
The
tolerance
for
mint
is
restricted
to
use
west
of
the
Cascade
Mountains
only,
and
the
tolerance
for
wild
rice
is
restricted
to
MN.
Sufficient
field
trial
42
data
are
available
to
assess
the
established
tolerances
with
regional
registrations
for
mint
and
wild
rice
at
the
same
levels.

Pending
Tolerance
Petitions
PP#
4F3007:
Syngenta
has
proposed
the
establishment
of
tolerances
for
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
dichlorobenzoic
acid
and
expressed
as
parent
compound
in/
on
pecans.

PP#
4G3075:
Syngenta
has
proposed
the
establishment
of
tolerances
for
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
dichlorobenzoic
acid
and
expressed
as
parent
compound
in/
on
rice
and
wheat.

PP#
9F3470:
Syngenta
has
proposed
the
establishment
of
tolerances
for
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
dichlorobenzoic
acid
and
expressed
as
parent
compound
in/
on
tree
nuts
at
0.1
ppm
and
almond
hulls
at
0.1
ppm.
The
petitioner
also
proposes
removal
of
the
established
tolerance
for
pecans
on
establishment
of
the
proposed
tree
nut
crop
group
tolerance.
The
petition
is
currently
in
reject
status
pending
resolution
of
certain
label
deficiencies
and
revision
of
the
proposed
use
pattern
(
DP
Barcodes
D229114
and
D234297,
3/
27/
97,
L.
Kutney;
DP
Barcode
D229723,
3/
26/
97,
L.
Kutney;
DP
Barcode
D222232
and
D216602,
3/
28/
96,
W.
Cutchin).

PP#
2F6371:
Syngenta
has
proposed
the
establishment
of
tolerances
for
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
dichlorobenzoic
acid
and
expressed
as
parent
compound
equivalent
in
or
on
strawberries,
sugar
beets,
wheat,
corn,
rice,
sorghum,
carrots,
onions,
berry
groupdry
beans,
soybeans,
almonds,
and
tree
nuts
as
follows.
This
petition
supercedes
PP#
4F3007,
4G3075,
5F4424,
5F4498,
5F4591,
9F3740
(
DP
Barcode
D312277,
313278,
313693,
not
reviewed)

PP#
5F4591:
Syngenta
has
proposed
the
establishment
of
tolerances
for
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
dichlorobenzoic
acid
and
expressed
as
parent
compound
in/
on
the
berry
crop
group
at
1.0
ppm,
green
onions
at
8.0
ppm,
dry
bulb
onions
at
0.3
ppm,
and
carrots
at
0.2
ppm.
Following
data
review,
HED
recommended
against
establishment
of
the
proposed
permanent
tolerances
because
of
deficiencies
pertaining
to
plant
metabolism,
residue
analytical
methods,
and
storage
stability.
HED
recommended
for
establishment
of
time
limited
tolerances
for
the
above
commodities
at
the
proposed
levels
pending
revisions
to
label
and
use
patterns
(
DP
Barcode
D219664,
6/
12/
96,
L.
Kutney).
This
petition
has
been
superceded
by
PP#
2F6371.
43
PP#
5F4424:
Syngenta
has
proposed
the
establishment
of
tolerances
for
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
dichlorobenzoic
acid
and
expressed
as
parent
compound
in/
on
soybeans
at
0.5
ppm,
soybean
forage
at
8.0
ppm,
soybean
fodder/
straw
at
8.0
ppm,
soybean
hay
at
25.0
ppm,
dry
beans
at
0.5
ppm,
dry
bean
vines/
forage
at
8.0
ppm,
and
dry
bean
hay
at
8.0
ppm.
The
petition
is
currently
in
reject
status
pending
revision
of
the
proposed
use
pattern
(
DP
Barcode
D246884,
and
DP
Barcodes
D210266
and
D210295,
3/
5/
97,
M.
Rodriguez),
(
D246884,
03/
10/
2005,
T.
Morton).
This
petition
has
been
superceded
by
PP#
2F6371.

PP#
5F4498:
Syngenta
Crop
Protection,
Inc.
has
proposed
the
establishment
of
inadvertent/
rtational
crop
tolerances
for
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
dichlorobenzoic
acid
and
expressed
as
parent
compound
equivalent
in
or
on
grain
sorghum,
grain
at
0.2
ppm;
grain
sorghum,
forage
at
0.3
ppm;
grainsorghum,
fodder
(
stover)
at
0.3
ppm;
alfalfa,
forage
at
0.1
ppm;
and
alfalfa,
hay
at
0.1
ppm.
(
DP
Barcode
D216415;
not
reviewed).
This
petition
has
been
superceded
by
PP#
2F6371.

PP#
9F3740:
Syngenta
Crop
Protection,
Inc.
has
proposed
the
establishment
of
tolerances
for
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
dichlorobenzoic
acid
and
expressed
as
parent
compound
equivalent
in
or
on
almonds
and
the
tree
nuts
crop
group.
(
DP
Barcode
D234716,
not
reviewed).
This
petition
has
been
superceded
by
PP#
2F6371.

PP#
6E4788:
Inter­
regional
Project
No.
4
(
IR­
4)
has
proposed
the
establishment
of
tolerances
for
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
dichlorobenzoic
acid
and
expressed
as
parent
compound
equivalent
in
or
on
celery.
(
DP
Barcode
D238458,
not
reviewed)

PP#
7E4860:
Inter­
regional
Project
No.
4
(
IR­
4)
has
proposed
the
establishment
of
tolerances
for
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
dichlorobenzoic
acid
and
expressed
as
parent
compound
equivalent
in
or
on
cranberry.
(
DP
Barcode
D238468,
not
reviewed)

PP#
8E4931:
Inter­
regional
Project
No.
4
(
IR­
4)
has
proposed
the
establishment
of
tolerances
for
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
dichlorobenzoic
acid
and
expressed
as
parent
compound
equivalent
in
or
on
mint.
(
DP
Barcode
D247313,
D313963,
not
reviewed)
44
Table
C.
Tolerance
Reassessment
Summary
for
Propiconazole.

Commodity
Current
Tolerance,
ppm
Reassessed
Tolerance,
ppm
Comment
[
Correct
Commodity
Definition]

Tolerances
Established
Under
40
CFR
§
180.434(
a)

Bananas
0.2
0.2
[
Banana]

Barley,
grain
0.1
0.3
Translated
from
wheat
data.
Memo
of
02/
02/
05,
Y.
Donovan,
D271790.

Barley,
straw
1.5
15.0
Translated
from
wheat
data.
Memo
of
02/
02/
05,
Y.
Donovan,
D271790.

Cattle,
fat
0.1
0.1
0.08
ppm
combined
residues
in
fat
were
expected
from
MTDB.

Cattle,
kidney
2.0
2.0
1.01
ppm
combined
residues
in
kidney
were
expected
from
MTDB.
However,
several
new
uses
are
pending
which
may
increase
the
MTDB.

Cattle,
liver
2.0
2.0
1.33
ppm
combined
residues
in
liver
were
expected
from
MTDB.
However,
several
new
uses
are
pending
which
may
increase
the
MTDB.

Cattle,
meat
byproducts,
except
kidney
and
liver
0.1
0.1
(
see
comments
above
in
fat)

Cattle,
meat
0.1
0.1
0.04
ppm
combined
residues
in
meat
were
expected
from
MTDB.
However,
several
new
uses
are
pending
which
may
increase
the
MTDB.

Celery
5.0
5.0
Corn,
field,
stover
12
12
Expiration
date
11/
30/
08
[
Corn,
field,
stover]

Corn,
field,
forage
12
12
Expiration
date
11/
30/
08
[
Corn,
field,
forage]

Corn,
field,
grain
0.1
0.1
Expiration
date
11/
30/
08
[
Corn,
field,
grain]

Corn,
sweet,
kernels
plus
cobs
with
husks
removed
0.1
0.1
Expiration
date
11/
30/
08
[
Corn,
sweet,
kernels
plus
cobs
with
husks
removed]

Eggs
0.1
Revoke
Feeding
study
data
indicate
that
tolerances
for
poultry
commodities
are
not
necessary.

Fruit,
Stone,
group
12
1.0
1.0
[
Fruit,
stone,
group
12]

Goat,
fat
0.1
0.1
(
see
comments
in
cattle)

Goat,
kidney
2.0
2.0
(
see
comments
in
cattle)

Goat,
liver
2.0
2.0
(
see
comments
in
cattle)
45
Commodity
Current
Tolerance,
ppm
Reassessed
Tolerance,
ppm
Comment
[
Correct
Commodity
Definition]

Goat,
meat
byproducts,
except
kidney
and
liver
0.1
0.1
(
see
comments
in
cattle)

Goat,
meat
0.1
0.1
(
see
comments
in
cattle)

Grass,
forage
0.5
0.5
Grass,
hay
(
straw)
40
40
[
Grass,
hay]

Grass,
straw
40
40
[
Grass,
straw]

Hog,
fat
0.1
0.1
(
see
comments
in
cattle)

Hog,
kidney
2.0
2.0
(
see
comments
in
cattle)

Hog,
liver
2.0
2.0
(
see
comments
in
cattle)

Hog,
meat
byproducts,
except
kidney
and
liver
0.1
0.1
(
see
comments
in
cattle)

Hog,
meat
0.1
0.1
(
see
comments
in
cattle)

Horse,
fat
0.1
0.1
(
see
comments
in
cattle)

Horse,
kidney
2.0
2.0
(
see
comments
in
cattle)

Horse,
liver
2.0
2.0
(
see
comments
in
cattle)

Horse,
mbyp
(
except
kidney
and
liver)
0.1
0.1
[
Horse,
meat
byproducts,
except
kidney
and
liver](
see
comments
in
cattle)

Horse,
meat
0.1
0.1
(
see
comments
in
cattle)

Milk
0.05
0.05
0.03
ppm
combined
residues
in
milk
were
expected
from
26.5ppm
MTDB.

Mushroom
0.1
0.1
Use
of
propiconazole
on
mushrooms
is
being
supported
by
IR­
4.
Currently
there
are
no
registered
uses
of
propiconazole
on
mushrooms.
[
Mushroom]

Oat,
forage
10.0
10.0
[
Oat,
forage]

Oat,
grain
0.1
0.1
[
Oat,
grain]

Oat,
hay
30.0
2.0
Translated
from
wheat
hay.
[
Oat,
hay]

Oat,
straw
1.0
1.0
[
Oat,
straw]

Peanut
0.2
0.2
Expiration
date
11/
30/
08
[
Peanut].
Parent
accounted
30%
of
the
TRR
based
on
peanut
metabolism
(
MARC
memo
of
4/
4/
02,
D279299).

Peanut,
hay
20.0
20.0
Expiration
date
11/
30/
08
[
Peanut,
hay]
46
Commodity
Current
Tolerance,
ppm
Reassessed
Tolerance,
ppm
Comment
[
Correct
Commodity
Definition]

Pecans
0.1
0.1
Syngenta
has
proposed
removal
of
the
established
tolerance
for
pecans
on
establishment
of
the
proposed
tree
nut
crop
group
tolerance
(
pending
tolerance
petition
PP#
9F3470).

Pineapple
0.1
0.1
Expiration
date
11/
30/
08
Pineapple,
fodder
0.1
Revoke
Expiration
date
11/
30/
08;
no
longer
considered
a
significant
livestock
feed
item.

Plum,
prune,
fresh
1.0
Revoke
This
tolerance
has
been
replaced
by
the
stone
fruits
group
tolerance.

Rice,
grain
0.1
0.3
The
available
data,
reflecting
the
maximum
registered
use
pattern,
indicate
that
the
maximum
combined
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
DCBA
were
0.28
ppm
in/
on
rice
grain.
(
HED
memo
of
02/
23/
05,
T.
Morton,
D240856).

Rice,
straw
3.0
3.0
(
HED
memo
of
02/
23/
05,
T.
Morton,
D240856).

Rye,
grain
0.1
0.3
Translated
from
wheat
data.
Memo
of
02/
02/
05,
Y.
Donovan,
D271790.

Rye,
straw
1.5
15.0
Translated
from
data
for
wheat
straw.

Sheep,
fat
0.1
0.1
(
see
comments
in
cattle)

Sheep,
kidney
2.0
2.0
(
see
comments
in
cattle)

Sheep,
liver
2.0
2.0
(
see
comments
in
cattle)

Sheep,
mbyp
(
except
kidney
and
liver)
0.1
0.1
(
see
comments
in
cattle)

Sheep,
meat
0.1
0.1
(
see
comments
in
cattle)

Wheat,
grain
0.1
0.30
Memo
of
02/
02/
05,
Y.
Donovan,
D271790.

Wheat,
straw
1.5
15.0
Memo
of
02/
02/
05,
Y.
Donovan,
D271790.

Tolerances
To
Be
Proposed
Under
40
CFR
§
180.434(
a)

Aspirated
grain
fractions
20
(
sorghum)
1
5.0
Memo
of
02/
02/
05,
Y.
Donovan,
D271790.
[
Grain,
aspirated
fraction]

Barley,
hay
None
established
2.0
Translate
from
wheat
hay
Corn,
pop,
grain
None
established
0.1
Translate
from
field
corn
Corn,
pop,
stover
None
established
12
Translate
from
field
corn
47
Commodity
Current
Tolerance,
ppm
Reassessed
Tolerance,
ppm
Comment
[
Correct
Commodity
Definition]

Corn,
sweet,
forage
None
established
12
Translate
from
field
corn
Corn,
sweet,
stover
None
established
12
Translate
from
field
corn
Rice,
bran
None
established
1.0
Concentration
factor
for
rice
bran
is
2.9x.
(
MRID45080811DER2)

Rice,
hulls
None
established
1.2
Concentration
factor
for
rice
hulls
is
3.8x.
(
MRID45080811DER2)

Rye,
forage
None
established
2.0
Memo
of
02/
02/
05,
Y.
Donovan,
D271790.

Wheat
forage
None
established
2.0
Memo
of
02/
02/
05,
Y.
Donovan,
D271790.
[
wheat,
forage]

Wheat
hay
None
established
2.0
Memo
of
02/
02/
05,
Y.
Donovan,
D271790.
[
Wheat,
hay]

Wheat
Bran
None
established
1.0
Memo
of
02/
02/
05,
Y.
Donovan,
D271790.
[
Wheat,
bran]

Tolerances
Established
Under
40
CFR
§
180.434(
b)

Blueberry
1.0
N/
A
Expiration
date
11/
31/
07.
Recommended
in
Agency
memo
of
02/
22/
05,
D.
Rate,
D313289.
[
Blueberry]

Cranberry
1.0
N/
A
Expiration
date
12/
31/
05
[
Cranberry]

Dry
bean
forage
8.0
N/
A
Expiration
date
12/
31/
05
[
Bean,
dry,
forage]

Dry
bean
hay
8.0
N/
A
Expiration
date
12/
31/
05
[
Bean,
dry,
hay]

Dry
bean
0.5
N/
A
Expiration
date
12/
31/
05
[
Bean,
dry]

Sorghum,
aspirated
grain
fractions
20
N/
A
Expiration
date
06/
30/
05
Sorghum,
grain,
grain
0.2
N/
A
Expiration
date
06/
30/
05
[
Sorghum,
,
grain,
grain]

Sorghum,
grain,
stover
1.5
N/
A
Expiration
date
06/
30/
05
Soy
bean,
bean
0.5
(
pending)
N/
A
Agency
memo
of
04/
14/
04,
J.
R.
Tomerlin,
D262299.

Soybean,
forage
8.0
(
pending)
N/
A
Agency
memo
of
04/
14/
04,
J.
R.
Tomerlin,
D262299.

Soybean,
hay
25.0
(
pending)
N/
A
Agency
memo
of
04/
14/
04,
J.
R.
Tomerlin,
D262299.

Tolerances
Established
Under
40
CFR
§
180.434(
c)
48
Commodity
Current
Tolerance,
ppm
Reassessed
Tolerance,
ppm
Comment
[
Correct
Commodity
Definition]

Sunflower
None
established
TBD
2
Peppermint,
tops;
[
Spearmint,
tops
0.3
0.3
Regional
registration
for
use
west
of
the
Cascade
Mountains
only.
[
Peppermint,
tops]
[
Spearmint,
tops]

Rice,
wild
0.5
0.5
MN
[
Rice,
wild]

1
The
20­
ppm
tolerance
for
sorghum
aspirated
grain
fractions
is
a
time­
limited
tolerance
to
support
a
Section
18
Exemption.

2
Tolerance
can
not
be
established
until
field
data
are
submitted.
49
CODEX
HARMONIZATION
The
Codex
Alimentarius
Commission
has
established
several
maximum
residue
limits
(
MRLs)
for
propiconazole
in/
on
various
raw
agricultural
commodities.
The
Codex
MRLs
are
expressed
in
terms
of
propiconazole
per
se,
which
is
in
harmonized
with
the
US
tolerance
expression.
HED
has
harmonized
tolerance
levels
on
most
commodities
that
have
Codex
MRLs
to
the
extend
possible.
A
numerical
comparison
of
the
Codex
MRLs
and
the
corresponding
reassessed
U.
S.
tolerances
is
presented
in
Table
D.

Table
D.
Codex
MRLs
for
Propiconazole
and
applicable
U.
S.
tolerances.

Codex
Commodity
(
As
Defined)
MRL
1
(
mg/
kg)
Step
Reassessed
U.
S.
Tolerance
(
ppm)
Recommendation
and
Comments
Almonds
0.05
CXL
­­
No
U.
S.
registration.

Banana
0.1
CXL
TBD
Barley
0.05
CXL
0.3
Coffee
beans
0.1
CXL
­­
No
U.
S.
registration.

Edible
offal
(
mammalian)
0.05
CXL
­­
No
U.
S.
registration.

Eggs
0.05
(*)
CXL
­­
No
U.
S.
registration.

Grapes
0.5
CXL
­­
No
U.
S.
registration
Mango
0.05
CXL
­­
No
U.
S.
registration.

Meat
(
from
mammals
other
than
marine)
0.05
(*)
CXL
0.1
Milks
0.01
(*)
CXL
0.05
Unable
to
harmonize
2
Oats
0.05
(*)
CXL
0.1
Peanut
0.05
CXL
0.1
Unable
to
harmonize
2
Peanut,
whole
0.1
CXL
 
Not
currently
regulated
by
U.
S.
EPA.

Pecan
0.05
CXL
0.1
Unable
to
harmonize
2
Poultry
meat
0.05
(*)
CXL
­­
No
U.
S.
registration.

Rape
seed
0.05
CXL
­­
No
U.
S.
registration.

Rye
0.05
(*)
CXL
0.3
Unable
to
harmonize
2
Stone
fruits
1
CXL
1.0
Sugar
beet
0.05
CXL
­­
No
U.
S.
registration.

Sugar
beet
leaves
or
tops
0.5
CXL
­­
No
U.
S.
registration.
50
Codex
Commodity
(
As
Defined)
MRL
1
(
mg/
kg)
Step
Reassessed
U.
S.
Tolerance
(
ppm)
Recommendation
and
Comments
Sugar
cane
0.05
CXL
­­
Use
in
the
U.
S.
is
considered
a
non
food
use.

Wheat
0.05
(*)
CXL
0.30
Unable
to
harmonize
due
to
higher
use
rate
1
Asterisk
designates
MRL
set
at
the
limit
of
quantitation.
2
Can
not
harmonize
because
current
use
patterns
in
the
U.
S.
supports
the
higher
value.
51
AGENCY
MEMORANDA
RELEVANT
TO
REREGISTRATION
CB
No.:
None
Subject:
PP#
4F3007
(
Acc.
Nos.
072212­
072217
and
072219):
CGA­
64250
(
Tilt)
in
Pecans.
Evaluation
of
Residue
Data
and
Analytical
Method
From:
A.
Smith
To:
H.
Jacoby
and
Toxicology
Branch
Dated:
5/
15/
84
MRID:
00067905,
00074495­
99,
00074500­
04,
00074508,
00074509,
00129915,
and
00155645
CB
No.:
None
Subject:
PP#
4F0326:
Tilt
on
Bananas.
Evaluation
of
Analytical
Methods
and
Residue
Data.
Accession
Nos.
072283,
072284,
072285.
From:
K.
Arne
To:
H.
Jacoby
and
Toxicology
Branch
Dated:
6/
20/
84
MRID:
00137150
CB
No.:
None
Subject:
PP#
4F3074
(
Accession
Nos.
072490,
072556,
072557):
Tilt
®
on
Small
Grains.
Evaluation
of
Residue
Data
and
Analytical
Method.
From:
A.
Smith
To:
H.
Jacoby
and
Toxicology
Branch
Dated:
7/
12/
84
MRID:
00137861
EFGWB
No.:
70289
Subject:
EFGWB
Review
of
Additional
Environmental
Data
for
Propiconazole
From:
E.
Regelman
To:
L.
Rossi
Dated:
3/
23/
87
MRID:
00129915,
00155645,
and
00164802
52
CB
No.:
2108
Subject:
PP#
4F3074,
4F3007,
and
4E3026.
Propiconazole
(
Tilt
®
or
CGA­
64250)
on
Crops
and
Livestock
Commodities.
Results
of
the
Multiresidue
Method
Testing.
From:
S.
Malak
To:
L.
Rossi
Dated:
4/
28/
87
MRID:
40100101
CB
No.:
2174
Subject:
PP#'
s
4F3074,
4F3007,
and
4E3026.
Propiconazole
(
Tilt
®
or
CGA­
64250)
on
Crops
and
Livestock
Commodities.
Additional
Recovery
Data,
Sample
Chromatograms,
and
Sample
Calculation
on
Analytical
Methods
AG­
454A
and
AG­
517.
Letter
of
April
6,
1987.
From:
S.
Malak
To:
L.
Rossi
Dated:
5/
7/
87
MRID:
40154501
CB
No.:
2172
Subject:
PP#'
s
4F3074,
4F3007,
and
4E3026.
Propiconazole
(
Tilt
®
or
CGA­
64250)
on
Crops
and
Livestock
Commodities.
Residue
Data
in
or
on
Livestock
Commodities
Using
Ciba­
Geigy's
Method
AG­
359.
Amendment
of
April
2,
1987.
From:
S.
Malak
To:
L.
Rossi
and
Toxicology
Branch
Dated:
5/
14/
87
MRID:
40150701
CB
No.:
2262
Subject:
PP#'
s
4F3074,
4F3007,
and
4E3026.
Propiconazole
(
Tilt
®
or
CGA
64250)
on
Crops
and
Livestock
Commodities.
Revisions
to
Analytical
Methods
AG­
454A
and
AG­
517.
Amendment
of
May
2,
1987.
From:
S.
Malak
To:
L.
Rossi
and
Toxicology
Branch
Dated:
5/
15/
87
MRID:
40180700­
40180702
53
EFGWB
No.:
70297
Subject:
EFGWB
Review
of
Submission
of
Metabolism
Data
for
Propiconazole
From:
E.
Regelman
To:
L.
Rossi
Dated:
5/
18/
87
MRID:
00155644
CB
No.:
2303
Subject:
PP#'
s
4F3074.
Propiconazole
(
Tilt
®
,
Banner,
or
CGA­
64250
®
)
on
Crops
and
Livestock
Commodities.
Revised
Sections
F
and
B.
Amendment
of
May
12,
1987.
From:
S.
Malak
To:
L.
Rossi
and
Toxicology
Branch
Dated:
5/
28/
87
MRID:
None
CB
No.:
None
Subject:
PP#
4F3074,
4F3007,
and
4E3026.
Propiconazole
(
Tilt
®
or
CGA­
64250)
on
Crops
and
Livestock
Commodities.
Evaluation
of
Method
Trial
Report
for
Ciba­
Geigy's
Method
AG454A
and
AG­
517.
From:
S.
Malak
To:
L.
Rossi
and
Toxicology
Branch
Dated:
5/
28/
87
MRID:
None
CB
No.:
4108
Subject:
PP#
8F3654,
Tilt
®
(
Propiconazole)
In
or
On
Peanuts
and
Peanut
Hulls/
Hay.
Evaluation
of
Analytical
Methodology
and
Residue
Data.
From:
H.
Fonouni
To:
L.
Rossi
and
Toxicology
Branch
Dated:
11/
22/
88
MRID:
40692201­
40692206
54
CB
No.:
4279
Subject:
PP#
8F3674.
Propiconazole
in/
on
Celery,
Corn,
Pineapples,
and
Legume
Vegetables.
Evaluation
of
the
Analytical
Methodology
and
Residue
Data.
From:
C.
Deyrup
To:
L.
Rossi
and
Toxicology
Branch
Dated:
12/
14/
88
MRID:
40783301,
40783303,
40783305,
40783306
CBRS
No.
4687
Subject:
EPA
Reg.
No.
100­
617.
Tilt
®
(
propiconazole)
residues
on
grass
seed
screenings
incorporated
into
animal
feed.
From:
L.
Propst
To:
L.
Rossi
Dated:
12/
15/
88
MRID:
None
EFGWB
No.:
90613
Subject:
EFGWB
Review
of
Request
to
Amend
Federal
Label
to
Permit
Double­
Cropping
of
Treated
Winter
Wheat
with
Soybeans
for
Propiconazole.
From:
E.
Regelman
To:
S.
Lewis/
Stone
Dated:
10/
19/
89
MRID:
41102001
CBTS
No.:
5226
­
5228
Subject:
PP#
9F3758
&
Reg.
Nos.
100­
617
&
100­
702.
Propiconazole
(
Tilt)
in
or
on
Wild
Rice
and
Stone
Fruit.
Evaluation
of
Residue
Data
and
Analytical
Methods.
From:
S.
Malak
To:
S.
Lewis
and
Toxicology
Branch
Dated:
11/
28/
89
MRID:
41063800­
41063803
55
CB
No.:
6724
Subject:
PP#
0F3869:
Propiconazole
(
Tilt
®
)
in
or
on
Celery.
Amendment
of
3/
1/
90.
From:
W.
Chin
To:
S.
Lewis
and
Toxicology
Branch
Dated:
8/
15/
90
MRID:
41486801
and
41486802
CB
No.:
7822
Subject:
PP
No.
1F3974.
Propiconazole
on
Grass
Seed
Screenings,
Straw,
and
Forage.
Evaluation
of
Residue
Data
and
Analytical
Methodology.
HED
Project
No.
1­
0964.
From:
S.
Willett
To:
S.
Lewis/
J.
Stone
and
Toxicology
Branch
Dated:
6/
11/
91
MRID:
41823300­
41823305
DP
Barcode:
D164460
Subject:
EFGWB
Review
of
Request
to
Remove
Double
Cropping
Restriction
from
Label
for
Propiconazole
(
EPA
Reg.
No.
100­
617).
From:
P.
Mastradone
To:
S.
Lewis/
S.
Jackson
Dated:
11/
7/
91
MRID:
None
DP
Barcode:
D171368
Subject:
PP
No.
9F3706.
Propiconazole
on
Grass
Seed
Screenings,
Straw,
and
Forage.
Ciba­
Geigy
Request
for
a
Waiver
for
Aerial
Field
Trial
Data
Requirements.
From:
S.
Willett
To:
S.
Lewis/
J.
Stone
and
Toxicology
Branch
Dated:
12/
18/
91
MRID:
None
DP
Barcode:
D170759
Subject:
PP#
2E04037.
Propiconazole
(
Tilt
®
Fungicide,
EPA
Reg.
No.
100­
617)
in
or
on
mint.
Evaluation
of
analytical
method
and
magnitude
of
residue
data.
From:
W.
Wassell
To:
H.
Jamerson
and
Toxicology
Branch
Dated:
2/
14/
92
MRID:
42061301
56
DP
Barcode:
D183633
Subject:
PP#
9F3758:
Propiconazole
(
Tilt,
Orbit)
in
Wild
Rice,
Apricots,
Nectarines,
Peaches,
Plums,
and
Prunes.
Amendment
of
October
8,
1992.
EPA
Reg.
Nos.
100­
618,
100­
617,
100­
702.
From:
M.
Rodriguez
To:
S.
Lewis/
S.
Jackson
Dated:
4/
8/
93
MRID:
42511401
DP
Barcode:
D189618
Subject:
PP#
2E04037.
Propiconazole
(
Tilt
®
Fungicide,
EPA
Reg.
No.
100­
617)
in
or
on
mint.
Questions
concerning
outstanding
data
requirements
(
letter
dated
3/
22/
93).
From:
W.
Wassell
To:
H.
Jamerson
Dated:
4/
12/
93
MRID:
None
DP
Barcode:
D185251
Subject:
PP#
8F3674
 
Propiconazole
(
Tilt
®
)
in/
on
Corn
and
Pineapple.
Ciba­
Geigy
Amendment
Dated
11/
20/
92.
From:
M.
Flood
To:
S.
Lewis/
S.
Jackson
Dated:
5/
6/
93
MRID:
42564004­
42564006
DP
Barcode:
D187417,
D190147,
and
D190263
Subject:
PP#
1F3974.
Propiconazole
(
Tilt
®
)
in/
on
Grasses
Grown
for
Seed.
Ciba­
Geigy
Amendment
Dated
1/
14/
93.
From:
M.
Flood
To:
S.
Lewis/
S.
Jackson
and
A.
Kocialski
Dated:
5/
12/
93
MRID:
42449501,
42634101,
and
42634102
57
DP
Barcode:
D190499
Subject:
PP#
9F3758:
Propiconazole
(
Tilt
®
,
Orbit
®
)
in
Wild
Rice,
Apricots,
Nectarines,
Peaches,
Plums,
and
Prunes.
Amendment
of
April
20,
1993.
EPA
Reg.
Nos.
100­
618,
100­
617,
100­
702.
From:
M.
Rodriguez
To:
S.
Lewis/
S.
Jackson
and
A.
Kocialski
Dated:
6/
2/
93
MRID:
None
DP
Barcode:
None
Subject:
PP#
8F3674
 
Propiconazole
in/
on
Corn
and
Pineapple.
Need
for
DRES
Analysis.
From:
M.
Flood
To:
S.
Lewis/
S.
Jackson
and
A.
Kocialski/
S.
Willett
Dated:
6/
15/
93
MRID:
None
DP
Barcode:
D174248
and
D175989
Subject:
PP#
2F4086.
Propiconazole
(
Tilt)
in/
on
Oat
Grain
and
Straw.
Evaluation
of
Analytical
Method
and
Residue
Data.
From:
R.
Lascola
To:
S.
Jackson/
S.
Lewis
Date:
7/
20/
93
MRID(
S):
42182901
DP
Barcode:
D191918
Subject:
PP#
8F3674.
Propiconazole
(
Tilt
®
)
in/
on
Corn
and
Pineapple.
Ciba­
Geigy
Amendment
Dated
5/
28/
93.
From:
M.
Flood
To:
S.
Jackson
Date:
9/
20/
93
MRID(
S):
None
58
DP
Barcode:
D192904
Subject:
PP#
1F3974.
Propiconazole
(
Tilt)
in/
on
Grasses
Grown
for
Seed.
Ciba­
Geigy
Amendment
Dated
7/
2/
93.
From:
M.
Flood
To:
S.
Jackson
and
A.
Kocialski
Date:
9/
20/
93
MRID(
S):
None
DP
Barcode:
D195566
Subject:
Propiconazole.
List
C
Reregistration
Case
No.
3125/
Chemical
ID
No.
112101.
6(
a)(
2)
Data:
Over­
tolerance
Residues
in
Rice
Grain
and
Processed
Fractions.
From:
C.
Swartz
To:
B.
Sidwell
Dated:
11/
2/
93
MRID:
42915600
and
42915601
DP
Barcodes:
D186202,
D186203,
D186205,
D186206,
and
D195499
Subject:
PP#
8F3654.
Propiconazole
(
Tilt
®
)
in/
on
Peanuts.
Amendment
Dated
12/
23/
92.
(
Received
CBTS
10/
1/
93).
From:
M.
Flood
To:
C.
Lewis
Dated:
11/
8/
93
MRID:
42605801
DP
Barcode:
D197841
Subject:
PP#
8F3654.
Propiconazole
(
Tilt
®
)
in/
on
Peanuts.
Amendment
Dated
12/
6/
93.
Request
for
Time­
Limited
Tolerances.
From:
M.
Flood
To:
S.
Jackson/
D.
Greenway
and
A.
Kocialski
Dated:
1/
25/
94
MRID:
None
DP
Barcode
D196789
Subject:
PP#
8F3674.
Propiconazole
(
Tilt
®
)
in/
on
Corn
and
Pineapple.
Submission
Dated
10/
25/
93.
From:
M.
Flood
To:
S.
Jackson/
D.
Greenway
Date:
3/
24/
94
MRID:
42983001
59
DP
Barcode:
D198815
Subject:
Propiconazole.
90
Day
Response.
Chemical
I.
D.
No.
122101.
List
C
Case
No.
3125.
From:
F.
Fort
To:
R.
Gebken/
B.
Sidwell
Dated:
4/
26/
94
MRID:
None
DP
Barcode:
D210742
Subject:
PP2F04086:
Propiconazole
in/
on
Oats.
Amendment
Dated
July
15,
1994;
Response
to
CBTS
#
s
9325/
9603.
From:
M.
Rodriguez
To:
S.
Lewis/
D.
Greenway
and
J.
Smith
Dated:
3/
15/
95
MRID:
43314201
and
43314202
DP
Barcode:
D209195
Subject:
PP#
5E04437,
Evaluation
of
Analytical
Method
and
Residue
Data.
Propiconazole
on
Mushrooms.
Chemical
#
122101.
From:
W.
Cutchin
To:
H.
Jamerson
Dated:
3/
29/
95
MRID:
43434201
DP
Barcode:
D209468
Subject:
PP#
2E04037.
Propiconazole
(
Tilt
®
Fungicide,
EPA
Reg.
No.
100­
617)
in
or
on
mint.
Amendment
submitted
on
10/
24/
94.
From:
W.
Wassell
To:
H.
Jamerson
and
J.
Smith
Dated:
4/
25/
95
MRID:
43424601
60
DP
Barcode:
D210252
Subject:
PP#
4F04321,
Propiconazole
in/
on
Stone
Fruit.
Request
for
Group
Tolerance.
Chemical
#
122101.
From:
W.
Cutchin
To:
C.
Welch
and
J.
Smith
Dated:
4/
25/
95
MRID:
None
DP
Barcode:
D217199
Subject:
PP#
4F04321
Amended
Petition:
Request
for
Group
Tolerance.
Propiconazole
in/
on
Stone
Fruit.
Crossover
Studies
for
New
Formulation.
Chemical
#
122101.
CBTS
#:
15866.
From:
W.
Cutchin
To:
C.
Welch
Dated:
8/
14/
95
MRID:
43655609
DP
Barcode:
D218453
Subject:
PP#
2F04086:
Propiconazole
in/
on
oats.
Amendment
Dated
April
7,
1995;
Response
to
CBTS
Review
#
14941.
From:
M.
Rodriguez
To:
C.
Welch/
K.
Scanlon
Dated:
8/
24/
95
MRID:
None
DP
Barcode:
D209612
Subject:
Propiconazole.
Registrant
Response.
Chemical
ID
No.
122101.
List
C
Case
No.
3125.
From:
F.
Fort
To:
R.
Gebken/
B.
Sidwell
Dated:
12/
19/
95
MRID:
None
61
DP
Barcodes:
D216602
and
D222232
Subject:
PP#
9F3740
Propiconazole
in/
on
Almonds,
Almond
Hulls,
and
Tree
Nut
Crop
Group.
Request
for
Group
Tolerance.
Revised
Section
Bs
and
New
Section
F.
Chemical
#
122101.
From:
W.
Cutchin
To:
C.
Welch
and
D.
McCall
Dated:
3/
28/
96
MRID(
s):
None
DP
Barcode:
D219664
Subject:
PP
No.
5F04591,
Propiconazole
on
the
berry
crop
grouping,
carrots,
and
onions
(
green
and
dry
bulb).
Chemical
No.
122101.
From:
L.
Kutney
To:
D.
McCall
Dated:
6/
12/
96
MRID(
s):
43786401­
43786404
DP
Barcode:
D210266
and
D210295
Subject:
PP#
5F04424
and
ID#
000100­
00618
CGA­
64250
Technical:
Propiconazole
in/
on
Dry
Beans
and
Soybeans.
Evaluation
of
Residue
Data
and
Analytical
Methodology.
From:
M.
Rodriguez
To:
D.
McCall/
S.
Robbins
Dated:
3/
5/
97
MRID(
s):
43386501
and
43386502
DP
Barcode:
D229723
Subject:
PP#
9F3740
Propiconazole
in/
on
Almonds,
Almond
Hulls,
and
Tree
Nut
Crop
Group.
Revised
Section
B
for
the
ORBIT
45W
Formulation.
Chemical
#
122101.
From:
L.
Kutney
To:
C.
Welch
and
K.
Scanlon
and
D.
McCall
Dated:
3/
26/
97
MRID:
None
62
DP
Barcodes:
D229114
and
D234297
Subject:
PP#
9F3740
Propiconazole
in/
on
Almonds,
Almond
Hulls,
and
Tree
Nut
Crop
Group.
Revised
Section
B
and
Section
F
for
ORBIT
and
ORBIT
GEL.
Chemical
#
122101.
From:
L.
Kutney
To:
C.
Welch
and
K.
Scanlon
and
D.
McCall
Dated:
3/
27/
97
MRID:
None
DP
Barcode:
D250861
Subject:
EXTENSION
OF
TIME
LIMITED
TOLERANCES
OF
PROPICONAZOLE
ON
CORN,
PINEAPPLES
(
PP#
8F3674)
AND
PEANUTS
(
PP#
8F3654)
From:
Margarita
Collantes,
To:
Mary
Waller,
PM
Team
21
Dated:
11/
19/
98
MRID:
None
DP
Barcode:
D220935
Subject:
Propiconazole
(
122101):
Residue
Analytical
Method
(
GLN
860.1340)
and
Storage
Stability
Data
(
GLN
860.1380).
Case
3125.
From:
T.
Morton
To:
M.
Hartman/
K.
Monk
Date:
3/
25/
99
MRID:
43825401
and
43825402
DP
Barcode:
D233755
Subject:
Propiconazole
(
122101):
Nature
of
the
Residue
Celery
(
GLN
860.1300)
and
Magnitude
of
the
Residue
in
Sugar
Cane
(
GLN
860.1500).
Case
3125.
From:
T.
Morton
To:
M.
Hartman/
K.
Monk
Dated:
9/
14/
99
MRID:
44049601
and
44142401
DP
Barcode:
D245249
Subject:
Propiconazole
(
122101):
Nature
of
the
Residue
in
Spring
Wheat
(
GLN
860.1300).
From:
T.
Morton
To:
M.
Hartman/
K.
Monk
Dated:
12/
14/
99
MRID:
44381402
63
DP
Barcode:
D284131
from:
Clark
Swentzel
TO:
Richard
Keigwin
Dated
:
07/
08/
02
Subject
:
Review
of
"
Profile
of
the
Triazole­
derivative
Fungicide
Compounds
and
their
Common
Metabolites".
Ingredient(
s)
:
004401
Amitrole,
120503
Bromuconacole
,128993
Cyproconazole,
128847
Difenoconazole,
123909
Epoxiconazole,
129011
Fenbuconazole,
128835
Flusilazole,
128925
Hexaconazole,
128851
Prochloraz,
125601
Paclobutrazol,
122101
Propiconazole.
MRID#:
45575501
DP
Barcode:
D267787,
D272054.
Subject:
PP#
0F06121.
PC
Code
129112.
CAS
#
141517­
21­
7.
Trifloxystrobin
on
Barley,
Citrus,
Corn
(
Field
and
Pop),
Pecan,
Pistachio,
Rice,
and
Stone
Fruit.
Review
of
Analytical
Methods
and
Residue
Data.
EPA
Reg
#
s:
3125­
559,
3125­
562.
From:
Leung
Cheng,
Chemist
To:
Cynthia
Giles­
Parker,
Team
22
Dated:
01/
17/
02
MRID:
45080800,
45080806,
45080808,
45080809,
45080810,
45080811,
45126200,
45269400,
45269401,
45269402,
45276400,
45276401.

DP
Barcode:
D281520
Subject:
Propiconazole
(
122101):
Reassessment
of
poultry
and
egg
tolerances.
From:
Bonnie
Cropp­
Kohlligian
To:
Eric
Olson,
CRM
Dated:
03/
06/
02
MRID:
None
DP
Barcode:
D279299
Subject:
Propiconazole
(
122101):
Results
of
the
HED
Metabolism
Assessment
Review
Committee
(
MARC)
Meetings
Held
on
18­
December­
2001
and
08­
January­
2002.
TXR#
0050349
From:
Bonnie
Cropp­
Kohlligian
To:
Yan
Donovan
Dated:
04/
04/
02
MRID:
None
DP
Barcode:
D
262299
Subject:
Propiconazole
(
122101):
Risk
Assessments
for
the
Section
18
Request
for
Control
of
Soybean
Rust
64
From:
J.
R.
Tomerlin
To:
Andrew
Ertman/
Section
18
Team
Dated:
04/
14/
04
MRID:
None
DP
Barcode:
D271790
Subject:
Propiconazole
(
122101):
Magnitude
of
Residues
in/
on
wheat
for
The
Registration
of
Stratego
 
use
on
wheat.
MRID
44757208.
From:
Yan
Donovan
To:
Susan
Lewis/
Patrick
Dobak
Dated:
02/
02/
05
MRID:
MRID
44757208
DP
Barcode:
D313289
Subject:
Propiconazole
(
122101):
Human
Health
Risk
Assessment
for
the
Section
18
Request
for
Blueberry
in
Maine.
From:
Debra
Rate
To:
Dan
Rossenblatt/
Andrea
Conrath
Dated:
02/
22/
05
MRID:
None
DP
Barcode:
D240856
Subject:
Residue
Analytical
Method(
GLN
860.1340),
Storage
Stability
Data(
GLN
860.1380),
Magnitude
of
the
Residue
in
Rice
and
Wheat
(
GLN
860.1500),
and
Magnitude
of
the
Residue
in
Processed
Food/
Feed
Commodities
of
Wheat
(
GLN
860.1520)
From:
Thurston
G.
Morton,
Chemist
To:
Mark
Hartman/
Kathy
Monk
Date:
02/
23/
05
MRID:
MRID
#
44411201,
44411202,
44411203,
44411204,
44411205,
44411206,
44411207,
44411208.

DP
Barcode:
D246884
Subject:
PP#
5F04424:
MRP
Soybean
Aspirated
Grain
Fractions
From:
Thurston
G.
Morton,
Chemist
To:
Mark
Hartman/
Kathy
Monk
Dated:
03/
10/
05
MRID:
44549101
65
MASTER
RECORD
IDENTIFICATION
NUMBERS
References
Used
To
Support
Reregistration
00067905
Fischer,
W.
C.;
Cassidy,
J.
E.
(
1980)
Balance
and
Metabolism
of
Triazole­
14C­
CGA­
64250
in
a
Lactating
Goat:
Report
No.
ABR­
80036.
(
Unpublished
study
received
Jan
28,
1981
under
100­
618;
submitted
by
Ciba­
Geigy
Corp.,
Greensboro,
N.
C.;
CDL:
244269­
G)

00074495
Marco,
G.
J.;
Kahrs,
R.
A.
(
1981)
CGA­
64250­­
Rice
and
Pecans:
Residues
Observed
and
Metabolism
Data
Including
the
Analytical
Methods
Used:
Report
No.
ABR­
81020.
(
Unpublished
study
received
Jun
8,
1981
under
100­
EX­
69;
submitted
by
Ciba­
Geigy
Corp.,
Greensboro,
N.
C.;
CDL:
070163­
A)

00074496
Madrid,
S.;
Cassidy,
J.
E.
(
1980)
The
Uptake,
Distribution
and
Characterization
of
Triazoleand
Phenyl­
14
C­
CGA­
64250
and
Their
Metabolites
in
Greenhouse­
grown
Peanuts:
Report
No.
ABR­
80006.
(
Unpublished
study
received
Jun
8,
1981
under
100­
EX­
69;
submitted
by
Ciba­
Geigy
Corp.,
Greensboro,
N.
C.;
CDL:
070164­
A)

00074497
Madrid,
S.
O.;
Cassidy,
J.
E.
(
1980)
Structure
Elucidation
of
Phase
I
Metabolites
of
CGA­
64250
in
Greenhouse­
grown
Peanut
Stalks:
Report
No.
ABR­
80037.
(
Unpublished
study
received
Jun
8,
1981
under
100­
EX­
69;
submitted
by
Ciba­
Geigy
Corp.,
Greensboro,
N.
C.;
CDL:
070164­
B)

00074498
Madrid,
S.
O.;
Cassidy,
J.
E.
(
1981)
The
Uptake,
Distribution
and
Characterization
of
Triazole­
14C­
CGA­
64250
and
Their
Metabolites
in
Field­
grown
Peanuts:
Report
No.
ABR­
81013.
(
Unpublished
study
received
Jun
8,
1981
under
100­
EX­
69;
submitted
by
Ciba­
Geigy
Corp.,
Greensboro,
N.
C.;
CDL:
070164­
C)

00074499
Seim,
V.;
Brown,
G.
(
1979)
Biological
Report
for
the
Metabolism
of
Triazole­
14C­
CGA­
64250
and
[
Phenyl]­
14C­
CGA­
64250
When
Applied
as
a
Foliar
Spray
to
Greenhouse
Grown
Peanuts:
Report
No.
BIOL­
79007.
(
Unpublished
study
received
Jun
8,
1981
under
100­
EX­
69;
submitted
by
Ciba­
Geigy
Corp.,
Greensboro,
N.
C.;
CDL:
070164­
D)

00074500
Blattmann,
P.
(
1979)
Metabolism
of
CGA
64
250
in
Field
Grown
Wheat:
Project
Report
36/
79.
(
Unpublished
study
received
Jun
8,
1981
under
100­
EX­
69;
prepared
by
Ciba­
Geigy,
Ltd.,
Switzerland,
submitted
by
Ciba­
Geigy
Corp.,
Greensboro,
N.
C.;
CDL:
070164­
E)

00074501
Blattmann,
P.
(
1980)
Proposed
Pathways
for
the
Degradation
of
CGA
64
250
in
Field
Grown
Wheat:
Project
Report
17/
80.
(
Unpublished
study
received
Jun
8,
1981
under
100­
EX­
69;
prepared
by
Ciba­
Geigy
Ltd.,
Switzerland,
submitted
by
Ciba­
Geigy
Corp.,
Greensboro,
N.
C.;
CDL:
070164­
F)
66
00074502
Blattmann,
P.
(
1980)
Metabolism
of
CGA
64
250
in
Grapevine:
Project
Report
42/
80.
(
Unpublished
study
received
Jun
8,
1981
under
100­
EX­
69;
prepared
by
Ciba­
Geigy
Ltd.,
Switzerland,
submitted
by
Ciba­
Geigy
Corp.,
Greensboro,
N.
C.;
CDL:
070164­
G)

00074503
Madrid,
V.;
Cassidy,
J.
E.
(
1981)
Characterization
of
Metabolites
in
Urine,
Milk
and
Liver
of
a
Goat
Treated
with
Triazole­
14C­
CGA­
64250:
Report
No.
ABR­
81007.
(
Unpublished
study
received
Jun
8,
1981
under
100­
EX­
69;
submitted
by
Ciba­
Geigy
Corp.,
Greensboro,
N.
C.;
CDL:
070164­
I)

00074504
Seim,
V.
W.;
Thomas,
W.
A.
(
1980)
Biological
Report
for
the
Metabolism
of
Triazole­
14CCGA
64250
in
a
Lactating
Goat:
Report
No.
BIOL­
80004.
(
Unpublished
study
received
Jun
8,
1981
under
100­
EX­
69;
submitted
by
Ciba­
Geigy
Corp.,
Greensboro,
N.
C.;
CDL:
070164­
J)

00074508
Ciba­
Geigy
Corporation
(
1981)
[
Residues
of
CGA­
64250
in
Rice
Field
Studies]:
AG­
A
6144.
(
Compilation;
unpublished
study,
including
AG­
A
6195,
AG­
A
6196,
AG­
A
6212...,
received
Jun
8,
1981
under
100­
EX­
69;
CDL:
070165­
A)

00074509
Ciba­
Geigy
Corporation
(
1981)
[
Residues
of
CGA­
64250
in
Pecans
in
Field
Studies]:
AG­
A
6203.
(
Compilation;
unpublished
study,
including
AG­
A
6291,
received
Jun
8,
1981
under
100­
EX­
69;
CDL:
070165­
B)

00074510
Ciba­
Geigy
Corporation
(
1981)
[
Residues
of
CGA­
64250
in
Soybeans
in
Field
Studies]:
AGA
6101.
(
Unpublished
study
received
Jun
8,
1981
under
100­
EX­
69;
CDL:
070165­
C)

00074511
Ross,
J.
A.
(
1981)
Stability
of
Residues
of
CGA­
64250
under
Freezer
Storage
Conditions:
Report
No.
ABR­
81018.
(
Unpublished
study
received
Jun
8,
1981
under
100­
EX­
69;
submitted
by
Ciba­
Geigy
Corp.,
Greensboro,
N.
C.;
CDL:
070165­
D)

00129915
Staley,
J.;
Madrid,
S.;
Cassidy,
J.
(
1982)
The
Uptake
of
Triazole
­
14C­
CGA­
64250
and
Its
Soil
Degradation
Products
in
Field
Rotational
Winter
Wheat,
Lettuce,
Corn
and
Carrots:
Report
No.:
ABR­
82007.
(
Unpublished
study
received
Jul
21,
1983
under100­
641;
submitted
by
Ciba­
Geigy
Corp.,
Greensboro,
NC;
CDL:
250783­
G)

00133385
Ciba­
Geigy
Corp.
(
1983)
CGA­
64250:
Pecans.
(
Compilation;
unpublished
study
received
Dec
12,
1983
under
100­
617;
CDL:
072212­
A;
072213;
072214;
072215;
072216;
072217)

00137150
Ciba­
Geigy
Corp.
(
1984)
CGA­
64250­­
Bananas.
(
Compilation;
unpublished
study
received
Jan
17,
1984
under
4E3026;
CDL:
072285­
A)

00137861
Ciba­
Geigy
Corp.
(
1984)
[
Residue:
CGA­
64250­­
Rice].
(
Compilation;
unpublished
study
received
Apr
6,
1984
under
4F3074;
CDL:
072556­
A;
072557)

00138266
Honeycutt,
R.
(
1983)
Rotational
Crop
Studies
with
CGA­
64250:
Report
No.
EIR­
83014.
(
Unpublished
study
received
Apr
4,
1984
under
100­
617;
submitted
by
Ciba­
Geigy
Corp.,
Greensboro,
67
NC;
CDL:
253013­
A)

00153327
Cheung,
M.
(
1985)
CGA­
64250­
Pecans:
Response
to
EPA's
Questions
Regarding
Section
D:
Residue
Chemistry
:
Report
No.
ABR­
85050.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
9
p.

00155644
Szolics,
I.;
Simoneaux,
B.
(
1985)
Metabolism
Data
and
Correlation
of
Metabolites
in
Target
and
Rotation
Crops
of
Propiconazole:
Report
No.
ABR­
85056.
Unpublished
study
prepared
by
Ciba­
Geigy.
45
p.

00155645
Madrid,
S.;
Cassidy,
J.
(
1983)
Soil
Uptake
of
Phenyl
Carbon­
14
vs.
Triazole
Carbon­
14
­
CGA­
64250
in
Target
Peanuts
Followed
by
Rotational
Winter
Wheat
and
Corn
­­
A
Side
by
Side
Comparison
Study
in
the
Greenhouse:
Report
No.
83030.
Unpublished
study
prepared
by
Ciba­
Geigy.
38
p.

00164802
Honeycutt,
R.
(
1986)
Additional
Residue
Information
on
Terrestrial
Rotation
Crops
Grown
after
Use
of
Propiconazole
on
Wheat,
Barley
or
Rye:
Report
No.
EIR­
86016.
Unpublished
compilation
prepared
by
Ciba­
Geigy
Corporation.
378
p.

40100101
Rhoads,
W.
(
1987)
Determination
of
the
Characteristics
of
Tilt
and
Its
Metabolites,
Including
1,2,4­
Triazole,
When
Subjected
to
Analysis
by
the
United
States
Food
and
Drug
Administration
(
FDA)
Multiresidue
Protocols
I,
II,
III
and
IV:
(
Residue
Analytical
Method):
Final
Report
:
Laboratory/
Study
No.
Ciba­
Geigy
1055.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
194
p.

40150701
Cheung,
M.
(
1987)
Response
to
EPA's
Concern
Regarding
the
Validity
of
Analytical
Method
AG­
359
to
Determine
Propiconazole
Residues
in
Animal
Commodities:
2,4­
Dichlorobenzoic
Acid
by
Capillary
Gas
in
Animal
Commodities:
(
Magnitude
of
Residues):
Lab
Study
No.:
ABR­
87039.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
624
p.

40154501
Cheung,
M.
(
1987)
Response
to
EPA's
Request
for
Additional
Recovery
Information
on
Analytical
Methods
AG­
454A
and
AG­
517:
Lab
Study
No.:
ABR­
87040.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
68
p.

40180701
Toth,
J.;
Manuli,
P.
(
1986)
Determination
of
Total
Residues
of
Propiconazole
in
Crops
as
2,4­
Dichlorobenzoic
Acid
by
Capillary
Gas
Chromatography:
Method
No.
AG­
454A.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
5
p.

40180702
Manuli,
P.
(
1987)
Determination
of
Total
Residues
of
Propiconazole
in
Meat,
Milk
and
Eggs
as
2,4­
Dichlorobenzoic
Acid
by
Capillary
Gas
Chromatography:
Laboratory/
Study
No.
AG­
517.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
4
p.

40692201
Cheung,
M.
(
1988)
Propiconazole­­
Peanuts:
Magnitude
of
Residue:
Laboratory
Project
ID:
68
ABR­
88068.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
128
p.

40692203
Perez,
R.;
Toth,
J.
(
1985)
Determination
of
Total
Residues
of
Propiconazole
in
Crops
as
2,4­
dichlorobenzoic
acid
by
Capillary
Gas
Chromatography:
Laboratory
Project
ID:
AG­
454.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
31
p.

40692204
Perez,
R.
(
1985)
Validation
of
Analytical
Methods
AG­
448
and
AG­
454
for
the
Determination
of
Residues
of
Propiconazole
in
Crops
by
Conversion
to
2,4­
dichlorobenzoic
acid:
Laboratory
Project
ID:
ABR­
85055.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
11p.

40692206
Nixon,
W.;
Rhoads,
W.
(
1983)
Validation
of
Analytical
Methods
AG­
448
and
AG­
454
for
the
Determination
of
Residues
of
CGA­
64250
in
Crops
by
Conversion
to
2,4­
dichlorobenzoic
acid:
Laboratory
Project
ID:
ABR­
83078.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
14
p.

40783301
Cheung,
M.
(
1988)
Propiconazole­
Celery:
Magnitude
of
Residue:
Project
ID:
ABR­
88057.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
77
p.

40783303
Cheung,
M.
(
1988)
Propiconazole­­
Corn:
Magnitude
of
Residues:
Project
ID:
ABR­
88054.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
208
p.

40783305
Cheung,
M.
(
1988)
Propiconazole­
Pineapple:
Magnitude
of
Residue:
Project
ID:
ABR­
88014.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
70
p.

40783306
Perez,
R.;
Toth,
J.
(
1985)
Determination
of
Total
Residues
of
CGA­
64250
in
Pineapples
as
2,4­
Dichlorobenzoic
Acid
by
Capillary
Gas
Chromatography:
Project
ID:
AG­
448.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
30
p.

40890701
Cheung,
M.
(
1988)
Propiconazole 
Grasses
Grown
for
Seed
Magnitude
of
Residue:
Laboratory
Project
ID
ABR­
88134.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
83
p.

41063801
Cheung,
M.
(
1989)
Propiconazole 
Wild
Rice
Residue
Summary:
Project
ID:
ABR­
89004.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
99
p.

41063802
Cheung,
M.
(
1989)
Propiconazole­
Stoned
Fruit
Residue
Summary:
Project
ID:
ABR­
89007.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
152
p.

41102001
Cheung,
M.
(
1989)
Propiconazole
in
Soybean
Beans,
Forage,
Hay,
and
Fodder
Double­
Cropped
behind
Winter
Wheat:
Project
No.
ABR­
89030.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
127
p.

41486801
Cheung,
M.
(
1990)
Propiconazole:
Response
to
EPA
Conclusions:
Propiconazole­
celery
Magnitude
of
Residue
(
Addendum
to
ABR­
88057,
MRID
No.
4078330,
MRID
No.
40783301):
Lab
Project
I.
D.:
ABR­
90026.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.,
Agricultural
Div.
49
p.
69
41486802
Darnow,
J.
(
1990)
Propiconazole:
Determination
of
Extract
Storage
Stability
for
Total
Propiconazole
Residues
in
Weathered
Crops:
Lab
Project
I.
D.:
ABR­
90017.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.,
Agricultural
Div.
56
p.

41823301
Doweyko,
A.
(
1990)
Metabolism
of
[
Phenyl
[
carbon
14]]
Propiconazole
in
Goats:
Lab
Project
Number:
F­
00052.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
66
p.

41823302
Doweyko,
A.
(
1990)
Metabolism
of
Phenyl
[
carbon
14]
Propiconazole
in
Chickens:
Lab
Project
Number:
F­
00051.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
71
p.

41823304
Yokley,
R.
(
1990)
Validation
of
Analytical
Method
AG­
517
for
the
Determination
of
Total
Residues
of
Propiconazole
in
Goat
Tissues,
Milk,
and
Blood
and
Poultry
Tissues:
Lab
Project
Number:
ABR­
90067.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
54
p.

41823305
Beidler,
W.
.
(
1991)
Propiconazole:
Magnitude
of
Residues
of
Propiconazole
in
Grasses
Grown
for
Seed
Following
Application
of
Tilt
3.6E:
Lab
Project
Number:
ANR­
90101.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
155
p.

42061301
Biehn,
W.
(
1991)
Propiconazole 
Magnitude
of
Residue
on
Mint:
Lab
Project
Number:
IR­
4
PR
4127.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
101
p.

42182901
Cheung,
M.
(
1991)
Propiconazole
Residues
in
Oat
Forage,
Straw,
Grain
and
Oat
Grain
Processed
Fractions
Resulting
from
Application
of
Tilt:
Residue
Summary
with
Amendment
1:
Lab
Project
Number:
ABR­
89102.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
214
p.

42511401
Smith,
J.
(
1991)
Propiconazole:
Response
to
EPA
Review
of
Propiconazole
(
TILT
3.6E)
on
Wild
Rice
Including
Results
of
Additional
Field
Trials:
Lab
Project
Number:
ABR­
90091.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
74
p.

42564004
Cheung,
M.
(
1992)
Responses
to
EPA
Review
of
Residue
Data
for
Propiconazole
on
Corn:
Lab
Project
Number:
ABR­
92064.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
91
p.

42564005
Manuli,
P.
(
1992)
Magnitude
of
Residues
of
Propiconazole
in
Field
Corn
Forage
and
Grain
and
Processed
Fractions
following
Application
of
Tilt
3.6E
Formulation
to
Field
Corn:
Lab
Project
Number:
ABR­
92047.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
161
p.

42564006
Doweyko,
A.
(
1992)
F­
00052:
Metabolism
of
[
Phenyl­
carbon
14]
Propiconazole
in
Goats:
Addendum
1
to
Final
Report.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
9
p.

42605801
Cheung,
M.
(
1992)
Propiconazole:
Responses
to
EPA
Review
of
Residue
Data
for
Propiconazole
on
Peanuts
Reported
in
ABR­
88068
MRID
Number
40692201:
Lab
Project
Number:
ABR­
92066.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
26
p.
70
42634101
Smith,
J.
(
1992)
Magnitude
of
Residues
of
Propiconazole
in
or
on
Grasses
Grown
for
Seed
following
Application
of
Tilt
3.6E:
Lab
Project
Number:
ABR­
92070.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
165
p.
42634102
Wurz,
R.
(
1993)
Propiconazole:
Magnitude
of
the
Residue
in
or
on
Grass
Seed
Screening
Pellets
Obtained
from
Market
Basket
Samplings:
Lab
Project
Number:
ABR­
92071.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
83
p.

42915601
Watson,
G.
(
1993)
Letter
sent
to
C.
Lewis
dated
September
3,
1993
concerning
a
report
of
Propiconazole
residues
above
current
tolerance
in
rice
commodities.
Prepared
by
Ciba­
Geigy
Corp.
10
p.

42983001
Doweyko,
A.
(
1990)
Metabolism
of
(
Phenyl­(
carbon
14))
­
Propiconazole
in
Chickens:
Addendum
I:
Lab
Project
Number:
F­
00051.
Unpublished
study
prepared­
84022
and
83091;
and
F­
00051.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
11
p.

43314201
Wurz,
R.
(
1994)
Stability
of
Total
Residues
of
Propiconazole
in
Weathered
Grass
Straw,
Forage
and
Seed
Samples
under
Freezer
Storage
Conditions:
Lab
Project
Number:
ABR/
94008.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.,
Biochemistry
Dept.
62
p.

43314202
Beidler,
W.
(
1994)
Response
to
EPA
Review
of
Petition
for
Tolerances
of
Propiconazole
in
Oat
Grain
and
Straw:
Lab
Project
Number:
ABR/
93068.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
Biochemistry
Dept.
11
p.

43424601
Thompson,
D.
(
1994)
Propiconazole:
Magnitude
of
Residue
on
Mint­­
Amendment:
Lab
Project
Numbers:
A4127:
4127:
A4127.93­
CIR01.
Unpublished
study
prepared
by
EPL
Bioanalytical
Services,
Inc.;
and
Ciba
Plant
Protection.
402
p.

43434201
Biehn,
W.
(
1994)
Propiconazole:
Magnitude
of
Residue
on
Mushroom:
Lab
Project
Number:
5056:
207S01:
5056.92­
PA05.
Unpublished
study
prepared
by
EPL
Bio­
Analytical
Services,
Inc.;
and
Lehigh
Agricultural
&
Biological
Services,
Inc.
291
p.

43655609
Selman,
F.
(
1995)
Propiconazole­­
Magnitude
of
the
Residues
in
or
on
Cherries
Following
Post
Foliar
Applications
of
Orbit:
Lab
Project
Number:
ABR/
95004.
Unpublished
study
prepared
by
Ciba
Plant
Protection.
225
p.

43825401
Lin,
K.
(
1995)
Propiconazole:
Investigations
into
the
Methylation
of
2,4­
Dichlorobenzoic
Acid
as
a
Part
of
Analytical
Methods
AG­
517
and
AG­
454B:
Lab
Project
Number:
ABR­
94065:
411925:
280­
94.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
141
p.

43825402
Eudy,
L.
(
1995)
Propiconazole:
Stability
of
Propiconazole
Fortified
into
Crops
and
Processed
Fractions
Under
Freezer
Storage
Conditions:
Interim
Report
61­
94.
Lab
Project
Number:
ABR­
95092:
411925:
207­
94.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
113
p.
71
44049601
Simoneaux,
B.
(
1996)
Uptake
and
Metabolism
of
CGA­
64250
in
Greenhouse
Grown
Celery
after
Spray
Treatment
with
Phenyl­(
carbon
14)­
CGA­
64250:
Lab
Project
Number:
ABR­
95100:
271­
94:
BIOL­
94015.
Unpublished
study
prepared
by
Ciba
Crop
Protection.
144
p.

44142401
Close,
C.
(
1996)
(
Carbon
14)­
Propiconazole:
Uptake
and
Metabolism
in
Seed
Piece
Dipped
Sugarcane:
(
Final
Report):
Lab
Project
Number:
ABR­
96097:
73­
95:
ANPHI­
96005.
Unpublished
study
prepared
by
Ciba­
Geigy
Corp.
56
p.

44381402
Swain,
W.
(
1997)
Uptake
and
Metabolism
of
CGA­
64250
in
Greenhouse
Grown
Spring
Wheat
after
Spray
Treatment
with
Phenyl­­(
carbon
14)­
CGA­­
64250:
Lab
Project
Number:
ABR­
97039:
502­
95:
BIOL­
95018.
Unpublished
study
prepared
by
Syngenta
Crop
Protection,
Inc.
170
p.

44411201
Lin,
K.
(
1997)
Determination
of
Total
Residues
of
Propiconazole
in
Crops
as
2,4­
Dichlorobenzoic
Acid
Methyl
Ester
by
Capillary
Gas
Chromatography:
Lab
Project
Number:
AG­
626:
571­
97:
411925.
Unpublished
study
prepared
by
Syngenta
Crop
Protection,
Inc.
45
p.
{
OPPTS
860.1340}

44411204
Lin,
K.
(
1997)
Determination
of
Total
Residues
of
Propiconazole
in
Meat,
Milk
and
Eggs
as
2,4­
Dichlorobenzoic
Acid
Methyl
Ester
by
Capillary
Gas
Chromatography:
Lab
Project
Number:
AG­
629:
572­
97:
411925.
Unpublished
study
prepared
by
Syngenta
Crop
Protection,
Inc.
44
p.
{
OPPTS
860.1340}

44411205
Eudy,
L.
(
1997)
Stability
of
Propiconazole
Fortified
into
Crops
and
processed
Fractions
Under
Freezer
Storage
Conditions:
Lab
Project
Number:
ABR­
97085:
207­
94:
477925.
Unpublished
study
prepared
by
Syngenta
Crop
Protection,
Inc.
84
p.
{
OPPTS
860.1380}

44411206
Vincent,
T.
(
1997)
Propiconazole­­
Magnitude
of
the
Residues
in
or
on
Wheat,
Including
Processed
Fractions
and
Rotational
Lentils
and
Peas,
Following
Post
Foliar
Applications
of
Tilt:
Lab
Project
Number:
ABR­
95062:
29­
92:
411124.
Unpublished
study
prepared
by
Syngenta
Crop
Protection,
Inc.
506
p.

44411207
Vincent,
T.
(
1997)
Propiconazole 
Magnitude
of
the
Residues
in
or
on
Wheat,
Including
Processed
Fractions,
Following
an
Application
of
Tilt:
Lab
Project
Number:
ABR­
97101:
94­
95:
411926.
Unpublished
study
prepared
by
Syngenta
Crop
Protection,
Inc.
314
p.
Relates
to
L0000296.

44411208
Vincent,
T.
(
1997)
Propiconazole 
Magnitude
of
the
Residues
in
or
on
Rice
Following
Application
of
Tilt:
Lab
Project
Number:
ABR­
97110:
49­
96:
411927.
Unpublished
study
prepared
by
Syngenta
Crop
Protection,
Inc.
120
p.

93194060
Senzel,
A.;
Ross,
J.;
Clear,
C.
(
1990)
Ciba­
Geigy
Corp.
Phase
3
Summary
of
MRID
00155643
and
Related
MRIDs
00164802­
00164823.
Field
Rotational
Crop
Studies
of
Propiconazole:
Project
EIR­
84002.
Prepared
by
CIBA­
GEIGY
CORP.
67
p.
72
93194062
Swidersky,
P.
(
1990)
Ciba­
Geigy
Corp.
Phase
3
Summary
of
MRID
00155644
and
Related
MRIDs
00074496,
00074499,
00074497,
00155646.
Metabolism
Data
and
Correlation
of
Metabolites
in
Target
and
Rotation
Crop
of
Propiconazole:
Report
No.
ABR­
85056.
Prepared
by
CIBA­
GEIGY
CORP.
17
p.

93194064
Wurz,
R.
(
1990)
Ciba­
Geigy
Corp.
Phase
3
Summary
of
MRID
40180701
and
Related
MRIDs
40022401,
40154501,
40692204.
Analytical
Method
for
the
Determination
of
Total
Residues
of
Propiconazole
in
Crops
as
2,4­
Dichlorobenzoic
Acid:
AG­
454A.
Prepared
by
CIBA­
GEIGY
CORP.
14
p.

93194066
Wurz,
R.
(
1990)
Ciba­
Geigy
Corp.
Phase
3
Summary
of
MRID
40100101.
Determination
of
the
Characteristics
of
Tilt
and
its
Metabolites
When
Subjected
to
Analysis
by
the
FDA
Multiresidues
Method
Protocols
I,
II,
III,
and
IV.
Prepared
by
Colorado
Analytical
Research
&
Dev.
Corp.
25
p.

93194067
Wurz,
R.
(
1990)
Ciba­
Geigy
Corp.
Phase
3
Summary
of
MRID
40180702
and
Related
MRIDs
40145401.
Analytical
Method
for
the
Determination
of
Total
Residues
of
Propiconazole
in
Meat,
Milk,
and
Eggs
as
2,4­
Dichlorobenzoic
Acid:
AG­
517.
Prepared
by
CIBA­
GEIGY
CORP.
13
p.

93194068
Beidler,
W.;
Senzel,
A.
(
1990)
Ciba­
Geigy
Corp.
Phase
3
Summary
of
MRID
00133385
and
Related
MRIDs
00074510,
00074511.
Stability
of
Propiconazole
Residues
on
of
Total
Residues
of
Propiconazole
of
Propiconazole
Residues
in
Crops
Under
Freezer
Storage
Conditions:
Projects
ABR­
83086
and
ABR­
81018.
Prepared
by
CIBA­
GEIGY
CORP.
11
p.

93194070
Senzel,
A.;
Ross,
J.;
Clear,
C.
(
1990)
Ciba­
Geigy
Corp.
Phase
3
Summary
of
MRID
00137861.
Cow
Meat
and
Milk­­
Feeding:
Propiconazole
Residues:
Projects
ABR­
84022
and
83091;
and
Poultry
Meat
and
Eggs:
Feeding:
Propiconazole
Residues:
Projects
ABR­
84022
and
83092.
Prepared
by
Ciba­
Geigy
Corporation.
36
p.

93194071
Senzel,
A.;
Ross,
J.;
Clear,
C.
(
1990)
Ciba­
Geigy
Corp.
Phase
3
Summary
of
MRID
00137150.
Magnitude
of
the
Residues
of
Propiconazole
in
Bananas:
ABR­
83100.
Prepared
by
CIBAGEIGY
CORP.
19
p.

93194072
Senzel,
A.;
Ross,
J.
(
1990)
Ciba­
Geigy
Corp.
Phase
3
Summary
of
MRID
00163643.
Magnitude
of
the
Residues
of
Propiconazole
in
Wheat,
Barley,
and
Rye:
Project
ABR­
84018.
Prepared
by
CIBA­
GEIGY
CORP.
16
p.

93194073
Senzel,
A.;
Ross,
J.;
Clear,
C.
(
1990)
Ciba­
Geigy
Corp.
Phase
3
Summary
of
MRID
40890701.
Magnitude
of
the
Residues
of
Propiconazole
in
Grasses
for
Seed:
Project
ABR­
83100.
Prepared
by
CIBA­
GEIGY
CORP.
17
p.

93194074
Senzel,
A.;
Ross,
J.
(
1990)
Ciba­
Geigy
Corp.
Phase
3
Summary
of
MRID
00133385
and
Related
MRIDs
00074508,
00074509,
00074495,
00153327.
Magnitude
of
the
Residues
of
73
Propiconazole
in
Pecans:
Project
ABR­
83069.
Prepared
by
CIBA­
GEIGY
CORP.
17
p.

93194075
Senzel,
A.;
Ross,
J.
(
1990)
Ciba­
Geigy
Corp.
Phase
3
Summary
of
MRID
00163687
and
Related
MRIDs
00074508,
00074509,
00074495,
00137861,
00163643,
41063801.
Magnitude
of
the
Residues
of
Propiconazole
in
Rice:
Project
ABR­
84022.
Prepared
by
CIBA­
GEIGY
CORP.
15
p.

93194077
Senzel,
A.;
Ross,
J.;
Clear,
C.
(
1990)
Ciba­
Geigy
Corp.
Phase
3
Summary
of
MRID
00131090.
Magnitude
of
the
Residues
of
Propiconazole
in
Sugarcane:
Project
ABR­
83065.
Prepared
by
CIBA­
GEIGY
CORP.
28
p.

93194079
Senzel,
A.;
Ross,
J.
(
1990)
Ciba­
Geigy
Corp.
Phase
3
Summary
of
MRID
00163687
and
Related
MRIDs
00074495,
00074508.
Magnitude
of
the
Residues
of
Propiconazole
in
Processed
Food/
Feed
from
Rice:
Project
ABR­
84022.
Prepared
by
CIBA­
GEIGY
CORP.
20
p.

93194080
Senzel,
A.;
Ross,
J.;
Clear,
C.
(
1990)
Ciba­
Geigy
Corp.
Phase
3
Summary
of
MRID
00163643.
Magnitude
of
the
Residues
of
Propiconazole
in
Processed
Food/
Feed
from
Wheat:
Project
ABR­
84018.
Prepared
by
CIBA­
GEIGY
CORP.
18
p.

93194085
Madrid,
V.;
Cassidy,
J.
(
1990)
Ciba­
Geigy
Corp.
Phase
3
Reformat
of
MRID
00074503
and
Related
MRIDs
00067905,
00074504.
Characterization
of
Metabolites
in
Urine,
Milk
and
Liver
of
a
Goat
Treated
with
Triazole­(
Carbon
14)­
CGA­
64250:
Propiconazole.
Prepared
by
CIBA­
GEIGY
CORP.
54
p.

45080807
Eudy,
L.
(
2000)
Propiconazole
and
CGA­
279202­
Magnitude
of
the
Residues
in
or
on
Sugar
Beet:
Final
Report:
Lab
Project
Number:
152­
98:
0W­
FR­
216­
98:
0W­
FR­
312­
98.
Unpublished
study
prepared
by
Novartis
Crop
Protection,
Inc.
141
p.
{
OPPTS
860.1500}

45080809
Vincent,
T.
(
2000)
Propiconazole
and
CGA­
279202­
Magnitude
of
the
Residues
in
or
on
Field
Corn
and
Pop
Corn:
Final
Report:
Lab
Project
Number:
751­
99:
MW­
FR­
317­
99:
MW­
FR­
318­
99.
Unpublished
study
prepared
by
Novartis
Crop
Protection,
Inc.
84
p.
{
OPPTS
860.1500,
860.1520}

45080810
Vincent,
T.
(
2000)
Propiconazole
and
CGA­
279202­
Magnitude
of
the
Residues
in
or
on
Field
Corn
and
Pop
Corn:
Final
Report:
Lab
Project
Number:
144­
98:
04­
FR­
004­
98:
0S­
FR­
201­
98.
Unpublished
study
prepared
by
Novartis
Crop
Protection,
Inc.
922
p.
{
OPPTS
860.1500,
860.1520}

45080811
Vincent,
T.
(
2000)
Propiconazole
and
CGA­
279202­
Magnitude
of
the
Residues
in
or
on
Rice:
Final
Report:
Lab
Project
Number:
150­
98:
03­
FR­
001­
98:
03­
FR­
104­
98.
Unpublished
study
prepared
by
Novartis
Crop
Protection,
Inc.
475
p.
{
OPPTS
860.1500,
860.1520}

44757208
Citation:
Vincent,
T.;
Ediger,
K.
(
1999)
Propiconazole
and
CGA­
279202­­
Magnitude
of
the
Residues
in
or
on
Wheat:
Final
Report:
Lab
Project
Number:
43­
97:
0S­
FR­
103­
97:
02­
FR­
002­
97.
Unpublished
study
prepared
by
Novartis
Crop
Protection,
Inc.
1304
p.
{
OPPTS
860.1000,
860.1500,
860.1520}
74
45080800
Citation:
Novartis
Crop
Protection,
Inc.
(
2000)
Submission
of
Residue
Chemistry
and
Environmental
Fate
Data
in
Support
of
the
Application
for
Registration
of
Flint
and
Trifloxystrobin
Technical,
and
the
Petition
for
Tolerance
of
Trifloxystrobin
in/
on
Barley,
Citrus
Fruit
Crop
Group,
Corn,
Popcorn,
Rice,
Pecans,
and
Stone
Fruit
Crop
Group.
Transmittal
of
12
Studies.

1.
Bolded
references
were
evaluated
in
the
Propiconazole
Phase
4
Review
dated
6/
25/
92,
by
B.
Cropp­
Kohlligian,
F.
Fort,
and
F.
Toghrol;
because
a
number
of
the
references
cited
in
the
Phase
4
Review
were
reviewed
in
connection
with
petitions
for
uses
which
have
since
been
registered,
in
some
cases
the
original
review
documents
are
noted
as
well.
All
other
references
were
reviewed
as
noted.

2.
Syngenta
is
required
to
amend
the
product
labels
for
the
41.8%
EC
formulations
(
100­
617
and
100­
737)
to
indicate
the
propiconazole
concentration
in
terms
of
lb
ai/
gal.
In
addition,
label
restrictions
which
prohibit
the
feeding
of
treated
forage
and/
or
hay
of
cereals
and
corn
to
livestock
must
be
removed
from
the
41.8%
EC
(
100­
617
and
100­
737)
and
the
45%
WP
(
100­
780)
formulations.
The
use
directions
for
rice
on
all
labels
should
be
amended
to
specify
a
45­
day
PHI.
HED
notice
that
the
maximum
number
of
applications
for
peanuts
on
Stratego
 
label
is
not
very
clear.
After
discussing
with
RD
and
the
registrant,
it
is
understood
that
the
maximum
number
of
six
applications
is
intended
only
for
the
7.0
oz
ai/
A
rate,
where
the
restricted
number
of
application
at
14
oz
ai/
A
is
only
two.
HED
recommends
that
the
petitioner
to
amend
the
Stratego
 
label
to
specify
these
instructions.
Since
there
are
adequate
field
trial
data
to
support
Section
3
registration
of
propiconazole
uses
on
wheat
at
the
rate
of
0.08
­
0.11
lbs
ai/
A/
application,
maximum
2
applications,
and
35
day
PHI
(
HED
memo
of
02/
02/
05,
Y.
Donovan,
D271790),
HED
recommends
increasing
the
existing
tolerances
on
wheat
RAC
to
cover
Stratego
Fungicide
(
EPA
Reg.
No.
264­
779)
uses
on
wheat.
These
new
reassessed
tolerances
will
cover
all
24C
uses
on
wheat
as
well.
HED
recommends
to
cancel
all
24C
uses
while
revising
the
Section
3
label
to
include
these
24C
uses.

3.
PP#
4F3007on
pecans,
RCB#
711,
5/
15/
84,
A.
Smith.

4.
DP
Barcode
D233755,
9/
14/
99,
T.
Morton.

5.
DP
Barcode
D245249,
12/
14/
99,
T.
Morton.

6.
Although
the
Phase
4
Review
concluded
that
additional
animal
metabolism
data
were
required,
the
Agency
concluded,
based
on
the
registrant's
90­
day
response
to
the
DCI,
that
the
available
data
were
adequate
to
satisfy
data
requirements
(
CB#
13166,
DP
Barcode
D198815,
4/
26/
94,
F.
Fort).

7.
PP#
8F3674,
CB#
11976,
DP
Barcode
D191918,
9/
20/
93,
M.
Flood.

8.
PP#
1F3974
on
grass
seed
screenings,
CB
No.
7822,
6/
11/
91,
S.
Willett.
75
9.
PP#
8F3674
on
corn
and
pineapple,
CB#
10974,
D185251,
5/
6/
93,
M.
Flood.

10.
PP#
8F3674
on
corn
and
pineapple,
CB#
12839,
DP
Barcode
D196789,
3/
28/
94,
M.
Flood.

11.
In
the
Phase
4
Review,
the
registrant
was
required
to
conduct
enforcement
method
validation
for
Method
AG­
454A
using
bananas.
This
requirement
is
no
longer
needed.

12.
PP#
4F3026,
RCB#
826,
6/
20/
84,
K.
Arne.

13.
PP#
4F3074
on
small
grains,
CB
No.
2174,
5/
7/
87,
S.
Malak.

14.
PP#
4F3074
on
small
grains,
CB
No.
2262,
5/
15/
87,
S.
Malak.

15.
PP#
8F3654
on
peanuts,
CB
No.
4108,
11/
22/
88,
H.
Fonouni.

16.
PP#
8F3674
on
legumes,
CB
No.
4279,
12/
14/
88,
C.
Deyrup.

17.
PP#
9F3758
on
rice,
wild
rice,
stone
fruits,
CB
Nos.
5226­
5228,
11/
28/
89,
S.
Malak.

18.
PP#
0F3869
on
cherry,
CB
No.
6724,
8/
15/
90,
W.
Chin.

19.
PP#
2E4027
on
mint,
DP
Barcode
D170759,
2/
14/
92,
W.
Wassell.

20.
PP#
2F4086
on
oats,
CB#
9325,
DP
Barcodes
D174248
and
D175989,
7/
20/
93,
R.
Lascola.

21.
PP#
8F3674
on
peanuts,
CB#
12638,
DP
Barcodes
D186202,
D186203,
D186205,
D186206,
and
D195499,
11/
8/
93,
M.
Flood.

22.
PP#
1F3979
on
grass
grown
for
seed,
CB#
11304,
DP
Barcodes
D187417,
D190147,
and
D190263,
5/
12/
93,
M.
Flood.

23.
PP#
2E4037
on
mint
hay,
CB#
14711,
DP
Barcode
D209458,
4/
25/
95,
W.
Wassell.

24.
PP#
5E4437
on
mushroom,
CB#
14693,
DP
Barcode
D209195,
3/
29/
95,
W.
Cutchin
25.
DP
Barcode
D220935,
3/
25/
99,
T.
Morton.

26.
DP
Barcode
D240856,
02/
23/
05,
T.
Morton.

27.
PP#
4F3074
on
small
grain/
pecans,
CB
No.
2172,
5/
14/
87,
S.
Malak.

28.
PP#
4F3074
on
small
grain/
pecans
CB
No.
2108,
4/
28/
87,
S.
Malak.

29.
PP#
2F4086
on
rice,
CB#
14941,
DP
Barcode
D210742,
3/
15/
95,
M.
Rodriguez.
76
30.
The
Phase
4
Review
concluded
that
additional
storage
stability
data
were
required
to
support
the
livestock
feeding
studies.
In
their
90­
day
response
to
the
DCI,
the
registrant
presented
data
to
satisfy
this
data
requirement
(
DP
Barcode
D198815,
4/
26/
94,
F.
Fort).

31.
Section
18
Exemption
with
associated
time­
limited
tolerance
on
dry
beans.
Use
of
propiconazole
on
dry
beans
has
been
proposed
under
pending
petition
PP#
5F4424
(
now
incorporated
into
PP#
2F6371).

32.
Establishment
of
a
stone
fruit
group
tolerance
was
approved
on
further
consideration
of
new
and
available
data
for
cherries
(
PP#
4F4321,
DP
Barcode
D217199,
8/
14/
95,
W.
Cutchin
and
DP
Barcode
D210252,
4/
25/
95,
W.
Cutchin).

33.
Section
18
Exemption
with
associated
time­
limited
tolerance
on
blueberry
in
Maine
(
Agency
memo
of
02/
22/
05,
D.
Rate,
D313289).
Use
of
propiconazole
on
the
berries
group
has
been
proposed
under
pending
petition
PP#
5F4591,
now
incorporated
into
PP#
2F6371.

34.
Section
18
Exemption
with
associated
time­
limited
tolerance
on
tree
nuts.
Use
of
propiconazole
on
tree
nuts
has
been
proposed
under
pending
petition
PP#
9F3470,
now
incorporated
into
PP#
2F6371.

35.
The
existing
tolerance
covers
the
registered
uses
of
propiconazole
on
pecans.
Syngenta
is
petitioning
for
a
tree
nut
group
tolerance
(
PP#
9F3740,
now
incorporated
into
PP#
2F6371),
which
will
be
handled
by
registration.

36.
The
available
data
pertaining
to
propiconazole
residues
of
concern
in/
on
wheat
grain
and
straw
supporting
the
currently
registered
maximum
use
pattern
(
D271790)
can
be
translated
to
barley
grain
and
straw
and
rye
grain
and
straw.

37.
PP#
4F3074,
RCB#
898,
7/
12/
84,
A.
Smith.

38.
PP#
8F3674
on
corn
and
pineapple,
03/
28/
94,
D196789,
M.
Flord.
The
new
submitted
storage
stability
data
are
adequate
and
indicate
that
propiconazole
is
stable
at
­
20
B
C
for
up
to
36
months
in
the
following
commodities:
peaches,
bananas,
corn
meal,
wheat
grain,
celery,
corn
oil,
and
peanut
nutmeat,
hay,
and
hulls.
Propiconazole
is
also
stable
in
carrots
for
up
to
10
months
at
­
20
B
C
(
Barcode
D240856).
Time­
limited
tolerances
have
been
extended
to
12/
31/
00
pending
review
of
a
modified
mid­
dose
carcinogenicity
study
in
mice
(
64
FR
13086,
13105,
3/
17/
99).
HED
believes
that
residues
from
corn
AGF
will
not
likely
to
be
higher
than
that
from
wheat
based
on
the
fact
that
wheat
grain
has
higher
residues
than
corn
grain,
therefore,
HED
recommends
a
5.0
ppm
tolerance
on
aspirated
grain
fractions
for
propiconazole.

39.
The
available
data
pertaining
to
field
corn
commodities
may
be
translated
to
popcorn
commodities.
77
40.
The
product
labels
for
the
41.8%
ECs
(
EPA
Reg.
Nos.
100­
617
and
100­
737)
must
be
modified
to
specify
a
45­
day
PHI
for
rice.

41.
DP
Barcode
D195566,
11/
2/
93,
C.
Swartz;
preliminary
6
(
a)
(
2)
data
on
rice.

42.
Section
18
Exemption
with
associated
time­
limited
tolerance
on
cranberries.
Use
of
propiconazole
has
been
proposed
by
IR­
4
under
pending
petition
PP#
7E4860.

The
registrant
submitted
data
reflecting
a
new
use
pattern
(
2x
the
current
use
pattern)
but
did
not
state
whether
they
wished
to
support
this
new
use
pattern.
If
the
registrant
desires
to
support
this
use
pattern,
then
additional
data
would
be
required
(
see
D240856).

44.
PP#
9F3758
on
wild
rice,
apricots,
nectarines,
peaches,
plums,
prunes.
DP
Barcode
D183633,
4/
8/
93,
M.
Rodriguez.

45.
Adequate
data
supporting
the
currently
registered
maximum
use
pattern
for
wheat
hay
and
forage
have
been
received
and
reviewed
(
HED
memo
of
02/
02/
05,
Y.
Donovan,
D271790).
They
can
be
translated
to
barley
hay
and
rye
forage.
The
product
labels
for
the
41.8%
EC
(
EPA
Reg.
Nos.
100­
617
and
100­
737)
and
the
45%
WP
(
EPA
Reg.
No.
100­
780)
formulations
must
be
modified
to
make
the
use
patterns
for
barley
and
rye
identical
to
wheat.

46.
Outstanding
deficiencies
pertaining
to
use
of
propiconazole
on
oats
(
PP#
2F04086)
have
been
resolved
by
proposal
of
a
tolerance
for
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
DCBA
in/
on
oat
hay
(
DP
Barcode
D218453,
8/
24/
95,
M.
Rodriguez).
Because
no
data
for
oat
hay
were
available,
the
appropriate
level
for
this
tolerance
was
calculated
from
data
for
oat
forage
using
a
3x
dry­
down
factor.
Currently,
data
for
wheat
hay
are
available,
and
these
data
can
be
translated
to
oats
to
determine
a
more
appropriate
level
for
the
oat
hay
tolerance.

47.
Adequate
data
on
wheat
have
been
submitted
and
reviewed
(
HED
memo
of
02/
02/
05,
Y.
Donovan,
D271790).
No
additional
data
are
needed.

48.
Additional
data
are
required
reflecting
residues
of
propiconazole
in/
on
grass
hay.
The
Agency
is
in
the
process
of
revising
its
policy
with
respect
to
residue
data
requirements
for
grass
grown
for
seed.
According
to
the
revised
policy,
residue
data
for
hay
may
be
based
on
regrowth
after
the
seed
has
been
harvested.

49.
Banana
field
trial
data
were
generated
in
Honduras,
Republic
of
Ivory
Coast,
Martinique,
and
Belize.
With
one
exception,
residues
did
not
exceed
the
tolerance
following
1­
13
aerial
or
ground
applications
of
the
250EC
formulation
at
41
g
ai/
A/
application
(=
0.090lbs
ai/
A/
application).
The
only
registered
uses
are
in
Hawaii
and
Puerto
Rico,
with
the
rate
of
0.084
lbs
ai/
A/
application
and
maximum
8
applications.
HED
concludes
that
the
existing
tolerance
on
banana
is
adequate.

50.
Use
of
propiconazole
on
mint
is
currently
supported
by
IR­
4
and
is
registered
under
SLN
78
OR960007.
A
tolerance
was
established
in
connection
with
PP#
2E4037.

51.
Use
on
mushrooms
is
being
supported
by
IR­
4.
A
tolerance
was
established
in
connection
with
PP#
5E4437.

52.
CBTS
recommended
for
the
establishment
of
time­
limited
tolerances
for
peanut
commodities
pending
receipt
of
additional
storage
stability
data
(
8F3654,
DP
Barcode
D197841,
1/
25/
94,
M.
Flood).
These
data
have
since
been
received
and
reviewed
(
DP
Barcode
D240856).

53.
The
available
data
indicate
that
treatment
of
sugarcane
pieces
according
to
the
currently
registered
use
pattern
can
be
considered
a
nonfood
use.

54.
The
available
data
indicate
that
treatment
of
sunflower
grown
for
seed
can
not
be
considered
a
nonfood
use.
Field
trial
data
on
sunflower
are
required
to
establish
tolerance.

55.
The
available
data
for
processed
wheat
commodities
may
be
translated
to
barley
and
rye.
(
HED
memo
of
02/
02/
05,
Y.
Donovan,
D271790).

56.
Data
must
be
submitted
depicting
the
potential
for
concentration
of
propiconazole
residues
of
concern
in
pineapple
juice.

57.
Preliminary
rice
processing
data
have
been
submitted,
indicating
the
potential
for
concentration
of
propiconazole
residues
of
concern
in
rice
bran
and
hulls.
The
results
of
the
full
study
have
not
been
submitted
and
remain
outstanding.

58.
The
Agency
has
determined
that
adequate
data
pertaining
to
magnitude
of
the
residue
in
the
processed
commodities
of
sorghum
are
available
to
support
the
Section
18
Exemption.
A
tolerance
was
proposed
in
connection
with
PP#
5F4498.

59.
EFGWB
concluded
that
this
requirement
has
been
fulfilled
(
DP
Barcode
D166460,
11/
7/
91,
P.
Mastrodone).

60.
EFGWB
No.
70298,
3/
23/
87,
E.
Regelman.

61.
EFGWB
No.
70297,
5/
18/
87,
E.
Regelman.

62.
EFGWB
No.
70102,
12/
24/
86,
E.
Regelman.

63.
EFGWB
No.
90613,
10/
19/
89,
E.
Regelman.

64.
Additional
data
would
be
required
to
revise
the
plantback
intervals
currently
specified
on
labels
for
products
with
uses
on
rotatable
crops.
Data
are
available
depicting
propiconazole
residue
in
rotational
lentils
and
peas
to
satisfy
requirements
for
field
rotational
crop
trial
data
for
potential
uses
in
the
Pacific
Northwest.
Residues
of
propiconazole
were
<
LOQ
(
0.05
ppm)
in/
on
all
79
matrices
harvested
from
rotational
legume
crops
planted
329­
376
days
posttreatment.