Document ID: EPA-HQ-OPP-2006-0347-0006
Agency: epa
Document Type: Supporting & Related Material
Title: 
Posted Date: 2006-09-22T04:00Z

Page
1of
63
UNITED
STATES
ENVIRONMENTAL
PROTECTION
AGENCY
WASHINGTON,
D.
C.
20460
OFFICE
OF
PREVENTION,
PESTICIDES
AND
TOXIC
SUBSTANCES
MEMORANDUM
Date:
7/
31/
06
Subject:
Propiconazole.
Petitions
for
Tolerances
on
Field,
Vegetable
and
Fruit
Crops.
Summary
of
Analytical
Chemistry
and
Residue
Data.
Petition
Numbers:
2F6371,
6E4788,
7E4860,
and
8E4931.

DP
Numbers:
D238458,
238468,
238583,
238597,
238598,
247313,
312277,
313199,
313201
Decision
Nos.:

PC
Code:
122101
MRID(
s):
43640401,
43655612,
43655613,
44338101,
44416501,
44548402,
44757207,
44757208,
44757210,
45080807,
45080809,
45080810,
45080811,
45215806,
45275801,
45542401,
45778901,
46473001,
46576302
40
CFR
180.434
Chemical
Class:
Triazole­
Type
Fungicide
From:
Yan
Donovan,
Chemist
Reregistration
Action
Branch
4
Health
Effects
Division
(
7509P)

Through:
Jerry
Stokes,
Chemist
Reregistration
Action
Branch
4
Health
Effects
Division
(
7509P)

Susan
Hummel
and
Richard
Loranger,
Senior
Scientists
Reregistration
Action
Branch
4
Health
Effects
Division
(
7509P)

To:
Mary
Waller/
Cynthia
Giles­
Parker
Fungicide
Branch
Registration
Division
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
2
of
63
This
document
was
originally
prepared
under
contract
by
Dynamac
Corporation
(
1910
Sedwick
Rd.,
Building
100,
Suite
B;
Durham,
NC
27713;
submitted
7/
14/
2006).
The
document
has
been
reviewed
by
the
HED
and
revised
to
reflect
current
OPP
policies.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
3
of
63
Executive
Summary
Propiconazole
is
a
triazole­
type
fungicide
(
Group
3)
that
provides
broad
spectrum
disease
control
on
a
variety
of
crops.
Tolerances
in/
on
plant
and
animal
commodities
are
currently
established
for
the
combined
residues
of
propiconazole,
1­[[
2­(
2,4­
dichlorophenyl)­
4­
propyl­
1,3­
dioxolan­
2­
yl]
methyl]­
1H­
1,2,4­
triazole,
and
its
metabolites
determined
as
2,4­
dichlorobenzoic
acid
(
2,4­
DCBA)
and
expressed
as
parent
[
40
CFR
§
180.434].
Tolerances
on
plant
commodities
range
from
0.1
ppm
on
several
commodities
to
40
ppm
in/
on
grass
hay
and
straw,
and
tolerances
on
animal
commodities
range
from
0.05
ppm
in
milk
to
2.0
ppm
in
liver
and
kidney
of
livestock.

Syngenta
Crop
Protection
(
Syngenta)
and
Interregional
Research
Project
No.
4
(
IR­
4)
have
submitted
several
petitions
supporting
new
or
amended
uses
on
various
crops
for
propiconazole,
formulated
as
a
3.6
lb/
gal
emulsifiable
concentrate
(
EC)
or
a
45%
wettable
powder
(
WP).
The
proposed
uses
are
for
broadcast
foliar
applications
using
ground
or
aerial
equipment
at
rates
ranging
from
0.11
to
0.28
lb
ai/
A/
application.
For
tree
nuts,
the
proposed
use
is
for
up
to
four
foliar
applications
at
0.225
lb
ai/
A,
for
a
total
of
0.90
lb
ai/
A,
with
a
60­
day
preharvest
interval
(
PHI).
For
bush
and
cane
berries
and
cranberries,
the
proposed
uses
are
for
4
or
5
foliar
applications
at
0.17
lb
ai/
A,
for
totals
of
0.68­
0.84
lb
ai/
A,
with
PHIs
of
30
or
45
days.
For
carrots,
leaf
petiole
vegetables,
dry
peas
and
beans,
sugar
beets
and
strawberries,
the
proposed
uses
are
for
3
or
4
broadcast
foliar
applications
at
0.11
lb
ai/
A,
for
totals
of
0.34
or
0.45
lb
ai/
A,
with
PHIs
of
0
to
21
days.
For
mint,
the
proposed
use
is
for
two
broadcast
foliar
applications
at
0.113
lb
ai/
A,
for
a
total
of
0.225
ai/
A,
with
a
PHI
of
30
days.
For
soybeans,
the
proposed
use
is
for
two
broadcast
foliar
applications
at
0.169
lb
ai/
A
at
up
to
growth
stage
R6,
for
a
total
of
0.338
ai/
A,
with
a
PHI
of
30
days.
For
rice,
the
proposed
use
is
for
a
single
application
or
split
applications
at
heading
totaling
~
0.30
lb
ai/
A,
with
a
PHI
of
35
days.
For
other
cereal
grains,
the
proposed
uses
are
for
2
to
4
broadcast
foliar
applications
at
0.113
lb
ai/
A
up
to
heading
or
grain
development,
for
totals
of
0.22
or
0.45
ai/
A,
with
PHIs
of
14­
45
days.
In
conjunction
with
these
uses,
Syngenta
and
IR­
4
are
proposing
permanent
tolerances
for
propiconazole
residues
in/
on
various
plant
commodities
at
levels
ranging
from
0.1
ppm
on
alfalfa
to
32
ppm
on
soybean
hay.

The
nature
of
propiconazole
residues
in
plants
and
animals
is
adequately
understood
based
on
the
available
peanut,
wheat,
grape,
rice,
celery,
carrot,
goat,
and
poultry
metabolism
studies.
A
major
metabolic
pathway
in
plants
appears
to
be
hydroxylation
(
primarily
of
the
beta­
carbon)
of
the
n­
propyl
group
on
the
dioxolane
ring
of
the
cis/
trans
isomers
of
propiconazole.
These
metabolites
appear
to
readily
form
sugar
conjugates.
The
majority
of
TRR
was
found
in
the
stalks,
such
as
peanut
stalk,
wheat
forage
and
straw,
grape
leaves,
and
celery
stalks.
The
HED
MARC
concluded
that
for
plants
and
animals,
residues
of
propiconazole
and
all
its
metabolites
containing
the
2,4­
dichlorophenyl
moiety
(
2,4­
DCBA),
including
conjugates,
are
of
concern
and
should
be
included
in
the
dietary
(
food)
risk
assessments,
and
that
propiconazole
per
se
should
be
included
in
the
dietary
(
water)
risk
assessments.
For
tolerance
expression,
MARC
concluded
that
the
current
tolerance
expression
for
propiconazole
should
be
amended
to
include
residues
of
propiconazole
per
se
only.
This
allows
for
harmonization
with
the
residue
definition
for
Codex.

The
free
triazole,
triazole
alanine,
and
triazole
acetic
acid
are
also
residues
of
concern.
Since
these
are
common
metabolites
from
several
triazole
containing
pesticides,
the
risk
assessment
for
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
4
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63
triazoles
has
been
assessed
separately
(
HED
memo
of
2/
7/
06,
M.
Doherty,
D322215).
The
cited
assessment
included
all
the
proposed
propiconazole
new
uses
in
the
subject
petitions.

For
enforcing
the
revised
tolerances,
a
GC
method
using
flame
ionization
detection
(
Method
AG­
354)
is
also
available
for
determining
residues
of
propiconazole
per
se
in/
on
plant
commodities,
and
has
an
LOQ
of
0.05
ppm.
In
addition,
Multiresidue
Methods
Section
302
can
also
be
used
to
determine
parent
propiconazole
in
both
plant
and
animal
matrices.

Samples
from
the
various
field
trials
and
processing
studies
supporting
the
current
petitions
were
analyzed
for
combined
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
using
GC/
ECD
Methods
AG­
454B
and
AG­
626,
which
are
more
recent
versions
of
AG­
454A.
With
the
exception
of
almond
hulls,
which
had
a
LOQ
of
0.1
ppm,
the
validated
LOQ
for
combined
residues
was
0.05
ppm
in
all
raw
and
processed
commodities.
Each
of
the
methods
was
validated
in
conjunction
with
the
field
trials
and
processing
studies.
In
addition,
samples
from
one
of
the
wheat
field
trials
and
processing
studies
were
also
analyzed
for
residues
of
propiconazole,
per
se,
using
a
multiresidue
method
from
the
Pesticide
Analytical
Manual
(
PAM,
Vol.
I,
Section
302).

Adequate
storage
stability
data
are
available
indicating
that
residues
of
propiconazole
are
stable
at
 ­
15
º
C
for
up
to
36
months
in
peaches,
bananas,
corn
meal,
wheat
grain,
celery,
corn
oil,
and
peanut
nutmeat,
hay,
and
hulls;
10
months
in
carrots;
and
4­
6
months
in
soybean
seed
and
fodder.
Weathered
residues
of
propiconazole
and
its
metabolites
were
also
found
to
be
stable
under
frozen
storage
conditions
in
grass
forage,
straw,
and
seed
for
up
to
39
months
at
­
20
º
C;
wild
rice
and
stone
fruits
for
up
to
25
months;
and
peanut
hulls
and
fodder
for
25
months
at
­
15
º
C.
These
data
support
most
of
the
samples
storage
intervals
and
conditions
in
the
field
trials
and
processing
studies
submitted
with
the
current
petitions.
In
cases
where
existing
storage
stability
data
are
not
available,
concurrent
storage
stability
data
were
submitted
along
with
field
trials.

Provided
that
minor
changes
are
made
to
the
proposed
use
directions,
the
available
field
trial
data
on
almonds,
bush
and
cane
berries,
carrots,
celery,
corn,
cranberries,
mint,
onions,
pecans,
rice,
sorghum,
strawberries
and
wheat
are
adequate
and
support
the
proposed
use
patterns
for
propiconazole
(
EC
or
WP)
on
these
crops.
The
number
and
geographic
distribution
of
the
field
trials
are
adequate,
and
the
appropriate
samples
were
collected.
Samples
were
analyzed
using
adequate
analytical
methods
and
the
sample
storage
intervals
are
supported
by
the
available
storage
stability
data.
Side­
by­
side
field
trials
were
conducted
on
almond,
celery,
field
corn,
and
sugar
beets
to
compare
residues
from
the
EC
and
WP
formulation.
These
data
show
residues
are
comparable
from
the
two
products,
with
the
exception
of
sugar
beet
tops
at
the
requested
PHI.

Adequate
field
trial
data
are
also
available
to
support
the
use
of
the
45%
WP
formulation
on
sugar
beets.
However,
based
on
the
results
of
the
side­
by­
side
tests
with
the
WP
and
EC
formulations,
residues
in/
on
tops
at
the
proposed
21­
day
PHI
are
likely
to
be
higher
for
the
EC
formulation
than
the
WP
formulation.
Therefore,
a
complete
set
of
field
trial
data
are
required
for
sugar
beet
tops
reflecting
the
use
of
the
EC
formulation.
A
conditional
registration
can
be
established
on
sugar
beet
tops.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
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63
For
soybeans,
after
considering
all
the
available
soybean
field
trial
data,
HED
concluded
that
sufficient
residue
data
are
available
to
support
tolerances
on
soybean
forage
and
hay
harvested
30
days
following
the
second
of
two
applications
totaling
0.33
lb
ai/
A
(
1x
rate).
Although
the
petitioner
has
requested
tolerances
for
soybean
forage
and
hay,
the
Agency
notes
that
the
currently
proposed
use
directions
for
soybean
prohibit
the
feeding
or
grazing
for
forage
or
hay.
HED
also
considers
sufficient
residue
data
are
available
to
support
tolerances
on
soybean
seed,
even
though
the
PHIs
of
the
soybean
seed
data
varies
from
30
to
90
days.
Since
soybean
mature
at
different
times
depending
on
the
growing
regions,
PHI
in
days
can
vary
from
region
to
region;
therefore,
provided
the
label
has
such
language
as
"
do
not
apply
later
than
the
R5
growth
stage'
or
`
apply
up
to
Stage
R6",
no
additional
field
trials
are
required
for
soybean
seeds.

For
dry
peas
and
beans,
however,
there
are
no
sufficient
field
trial
data
to
support
the
proposed
use
as
only
six
dry
bean
field
trials
are
available
and
no
dry
pea
field
trials
were
conducted.
For
a
subgroup
crop
tolerance
on
6C,
a
total
of
12
dry
bean
field
trials
and
5
dry
pea
field
trials
are
required.
In
addition,
the
available
dry
bean
field
trials
support
a
PHI
of
28
days
rather
than
the
14­
day
PHI
on
the
proposed
label.
HED
recommends
against
the
establishment
of
permanent
tolerance
on
subgroup
crop
6C
until
additional
field
trial
data
are
submitted.

The
Agency's
Guidance
for
Setting
Pesticide
Tolerances
Based
on
Field
Trial
Data
(
tolerance
spread
sheet)
was
utilized
for
determining
appropriate
tolerance
levels
on
plant
commodities.
While
these
tolerance/
residue
levels
are
suitable
for
Tier
I
dietary
risk
assessment,
they
are
considered
conservative
for
tolerances
in
that
the
field
trial
data
were
reported
as
parent
plus
all
metabolites
containing
2,4­
DCBA,
while
the
tolerance
expression
is
parent
only.
HED
recommends
that
the
registrant
analyze
parent
and
metabolites
separately
in
all
future
field
trials,
so
that
more
realistic
tolerances
can
be
set
in
the
future.

Adequate
processing
studies
are
available
for
alfalfa
(
rotational
crop),
field
corn,
mint,
rice,
sorghum,
soybean,
sugar
beet,
and
wheat.
These
studies
indicate
that,
with
the
exception
of
aspirated
grain
fractions
(
AGF),
combined
propiconazole
residues
did
not
concentrate
in
processed
commodities
derived
from
alfalfa,
field
corn,
mint,
sorghum,
and
soybeans,
or
in
polished
rice,
sugar
beet
refined
sugar,
or
wheat
germ,
shorts,
middlings
and
flour.
However,
combined
residues
were
shown
to
concentrate
in
rice
hulls
(
3.8x)
and
bran
(
2.9x),
sugar
beet
molasses
(
7.4x)
and
dried
pulp
(
4.9x),
and
wheat
bran
(
3.2x).
Considering
the
highest
average
field
trial
(
HAFT)
residues
in
the
various
RACs
and
the
above
processing
factors,
appropriate
tolerances
for
combined
propiconazole
residues
are
20
and
15
ppm
for
rice
hulls
and
bran,
1.5
and
1.0
ppm
for
sugar
beet
molasses
and
dried
pulp,
and
0.6
ppm
for
wheat
bran.
The
recommended
tolerance
for
wheat
bran
will
be
translated
to
bran
of
barley
and
rye.
With
regards
to
AGF,
combined
residues
were
also
shown
to
concentrate
by
various
degrees
in
AGF
derived
from
field
corn
(
12.8x),
sorghum
(
5.2x),
soybeans
(
32x),
and
wheat
(
18x)
following
late
season
applications.
Considering
these
AGF
concentration
factors
and
the
HAFT
residues
in
the
respective
RACs,
the
maximum
expected
residues
in
AGF
are
1.28
ppm
for
corn,
10.9
ppm
for
sorghum,
30
ppm
for
soybean,
and
3.2
ppm
for
wheat.
Therefore,
the
recommended
tolerance
for
propiconazole
residues
in
AGF
is
30
ppm
based
on
the
soybean
data.

The
maximum
theoretical
dietary
burdens
(
MTDB)
for
combined
propiconazole
residues
were
calculated
to
be
29.0
ppm
for
beef
and
18.5
ppm
for
dairy
cattle,
2.3
ppm
for
swine
and
2.0
ppm
Propiconazole
Summary
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Chemist
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Residue
Data
Barcode
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Page
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for
poultry.
To
estimate
maximum
combined
residues
in
cattle
and
swine
commodities,
the
residue
levels
for
the
75­
ppm
feeding
level
at
21
days
were
selected
as
these
residue
levels
were
the
highest
for
the
75­
ppm
group.
This
feeding
level
represents
a
2.7x
the
MTDBs
for
beef
cattle,
4.2x
for
dairy
cattle,
and
a
32.6x
for
swine.
Maximum
combined
residues
were
estimated
by
dividing
the
residue
values
for
milk
and
tissues
at
the
75­
ppm
dose
level
by
2.7
for
cattle,
4.2
for
milk,
and
32.6
for
swine.
For
beef
cattle,
estimated
combined
residues
at
a
1x
feeding
level
are
1.7
ppm
for
kidney,
1.6
ppm
for
liver,
0.03
ppm
for
muscle,
0.05
ppm
for
fat,
and
0.03
pm
for
milk.
For
swine,
estimated
combined
residues
at
a
1x
feeding
level
are
0.14ppm
for
kidney,
0.13
ppm
for
liver
and
<
0.005
ppm
for
muscle
and
fat.
HED
recommends
that
the
following
tolerance
levels
be
established:
For
cattle,
goat,
horses
and
sheep,
kidney
and
liver
at
2.0
ppm;
meat
and
meat
byproduct
(
except
kidney
and
liver)
and
fat
at
0.05
ppm,
milk
at
0.05
ppm.
For
hog,
kidney
and
liver
at
0.20
ppm,
no
tolerances
are
needed
for
meat,
fat,
and
meat
byproduct.

For
poultry
tissues
and
eggs,
estimated
combined
residues
and
parent
residues
were
calculated
in
the
same
manner
as
for
cattle
and
swine.
The
maximum
combined
residues
in
tissues
and
eggs
from
the
7.5­
ppm
dose
group
in
the
poultry
feeding
study
were
used
to
estimate
residues
at
the
1x
feeding
level.
The
estimated
combined
residues
at
the
1x
feeding
level
are
all
<
LOQ.
Therefore,
tolerances
for
poultry
tissues
and
eggs
are
not
required
as
quantifiable
levels
of
propiconazole
are
unlikely
to
occur
in
these
commodities
[
40
CFR
180.6(
a)
(
3)].

Adequate
confined
rotational
crop
studies
are
available
indicating
that
the
residues
in
rotational
crops
are
similar
to
the
primary
crops.
The
confined
studies
also
support
the
105­
day
plant­
back
interval
(
PBI)
currently
listed
on
product
labels
for
crops
without
direct
uses.
Under
the
current
petition,
Syngenta
has
submitted
extensive
rotational
crop
field
trial
data
on
alfalfa
planted
following
propiconazole­
treated
wheat
and
proposed
a
0.1
ppm
tolerance
for
inadvertent
residues
in/
on
alfalfa.
The
available
alfalfa
rotational
crop
field
trials
are
adequate
and
will
support
a
75­
day
PBI
for
alfalfa
following
propiconazole
application(
s)
to
primary
crops
at
up
to
0.22
lb
ai/
A/
season.

Residue
Chemistry
Deficiencies
With
the
exception
of
the
residue
data
for
dry
peas
and
beans,
and
sugar
beet
tops,
no
major
deficiencies
were
noted
in
the
subject
petitions
that
would
preclude
establishing
permanent
tolerances
for
propiconazole
on
the
proposed
commodities.
Pending
the
favorable
outcome
of
the
aggregate
risk
assessment,
HED
recommends
establishing
permanent
tolerances
for
propiconazole
residues
at
the
levels
recommended
in
the
Table
9.
As
insufficient
field
trial
data
are
available
on
dry
peas
and
beans
(
subgroup
6C),
HED
recommends
against
establishing
permanent
tolerances
on
these
commodities
at
this
time
until
additional
field
trials
are
submitted.
A
conditional
registration
can
be
established
on
sugar
beet
tops.
A
human
health
risk
assessment
is
forthcoming.

°
Label
directions
for
the
EC
and
WP
formulations
must
be
amended
to
include
the
recommended
changes
listed
under
the
`
Directions
for
use'
section.

°
To
support
the
use
of
the
EC
formulation
on
sugar
beets,
an
additional
8
sugar
beet
field
trials
are
required
using
a
representative
EC
formulation.
As
the
available
data
indicate
that
residues
in/
on
roots
are
similar
for
the
WP
and
EC
formulations,
only
residue
data
on
Propiconazole
Summary
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Residue
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sugar
beet
tops
are
required
from
these
trials.
HED
recommends
that
registration
of
the
EC
on
sugar
beets
be
conditional
upon
the
data
on
tops.

°
A
total
of
12
dry
bean
field
trials
and
5
dry
pea
field
trials
are
required
to
support
the
proposed
tolerance
on
the
dry
pea
and
bean
subgroup
6C.
Only
five
dry
bean
field
trials
are
available,
and
they
support
a
28­
day
PHI
rather
than
the
proposed
14­
day
PHI.
Additional
7
trials
on
dry
beans
and
5
trials
on
dry
peas
at
the
proposed
rates
are
needed.

°
Since
data
are
available
supporting
tolerances
on
soybean
forage
and
hay,
the
petitioner
may
delete
the
"
prohibit
animal
grazing"
or
"
prohibit
feeding
hay
to
livestock"
on
the
label.

°
The
available
wheat
field
trial
will
only
support
a
maximum
use
rate
of
0.11
lb
ai/
A
prior
to
the
harvest
of
forage
or
hay.
Label
must
be
revised
to
specify
that
no
more
than
0.11
lbs
ai/
A
be
applied
before
the
harvest
of
forage
and
hay.
If
the
petitioner
intends
to
support
the
use
of
two
applications
totaling
0.22
lb
ai/
A
prior
to
harvest
of
forage
and
hay,
then
an
additional
8
field
trials
are
required
on
forage
and
a
complete
set
of
20
field
trials
are
required
for
hay.

°
The
available
field
corn
and
sorghum
field
trial
data
will
only
support
applications
totaling
0.22
lb
ai/
A
prior
to
the
harvest
of
forage.
If
the
petitioner
intends
to
support
total
application
rate
up
to
0.44
lb
ai/
A
prior
to
the
harvest
of
forage,
than
additional
field
corn
and
sorghum
forage
data
will
be
required
to
support
the
higher
use
rate.

°
As
propiconazole
is
one
of
the
triazole
producing
pesticides,
any
requests
for
new
uses
submitted
after
September
1,
2005
will
require
data
related
to
assessing
the
common
metabolites.
For
detailed
information,
please
refer
to
HED
memo
of
4/
25/
06,
M.
Doherty,
D327788.
"
Guidance
on
Residue
Chemistry
Data
Submission".
Propiconazole
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Background
Propiconazole
is
a
triazole­
type
fungicide
(
Group
3)
that
provides
broad
spectrum
disease
control
through
inhibition
of
sterol
biosynthesis
in
fungi.
It
is
registered
to
Syngenta
Crop
Protection
for
the
control
of
fungal
diseases
on
a
variety
of
crops.
It
is
formulated
as
3.6
lb/
gal
emulsifiable
concentrates
(
EC)
and
45%
wettable
powder
(
WP).
Propiconazole
end­
use
products
are
marketed
in
the
United
States
under
the
trade
names
Tilt
®
,
Alamo
®
,
Banner
®
,
and
Orbit
®
.
Recently,
propiconazole
is
also
registered
for
use
on
a
variety
of
crops
under
the
trade
names
of
Stratego
 
Twin­
Pak
 
and
Stratego
 
,
which
are
end­
use
products
containing
a
mixture
of
trifloxystrobin
and
propiconazole.

Permanent
tolerances
are
currently
established
for
the
combined
residues
of
propiconazole,
1­
[[
2­(
2,4­
dichlorophenyl)­
4­
propyl­
1,3­
dioxolan­
2­
yl]
methyl]­
1H­
1,2,4­
triazole,
and
its
metabolites
determined
as
2,4­
DCBA
and
expressed
in
parent
equivalents,
at
levels
ranging
from
0.1
ppm
on
numerous
plant
commodities
to
40
ppm
in/
on
grass
hay
and
straw
[
40
CFR
§
180.434(
a)].
Permanent
tolerances
are
also
established
for
the
combined
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
DCBA
at
0.1
ppm
in
fat,
meat,
and
meat
byproducts
(
except
liver
and
kidney)
of
livestock,
2.0
ppm
in
liver
and
kidney
of
livestock,
and
at
0.05
ppm
in
milk;
however,
no
tolerances
have
been
established
for
eggs
and
poultry
commodities.
Time­
limited
tolerances
are
established
for
combined
propiconazole
residues
in/
on
a
variety
of
plant
commodities
at
levels
from
0.2
ppm
in/
on
sorghum
grain
to
25
ppm
in/
on
soybean
hay
[
40
CFR
§
180.434(
b)].
In
addition,
tolerances
with
regional
restrictions
have
been
established
for
combined
propiconazole
residues
at
0.3
ppm
in/
on
mint
tops
and
0.5
ppm
in/
on
wild
rice
[
40
CFR
§
180.434(
c)].

Syngenta
previously
submitted
a
series
of
petitions
(
PP#
s
4F3007,
4G3075,
5F4424,
5F4591,
and
9F3740)
supporting
the
use
of
propiconazole,
formulated
as
an
EC,
on
tree
nuts,
corn,
cereal
grains,
legume
vegetables,
soybeans,
berries,
strawberry,
sugar
beet,
carrots
and
onions.
These
petitions
have
been
superseded
by
a
single
petition
(
PP#
2F6371),
which
includes
new
or
amended
use
directions
for
the
above
crops.
In
conjunction
with
these
petitions,
Syngenta
is
proposing
the
following
permanent
tolerances
as
of
7/
18/
05.

AGF
..................................................................................................
17.0
ppm
Almond,
hulls
.....................................................................................
8.0
ppm
Crop
group
6,
Legume
vegetables,..................................................
1.0
ppm
Crop
Group
7,
Foliage
of
legume
vegetables
 .         .
10.0
ppm
Crop
Group
7,
Forage
of
legume
vegetables          
32.0
ppm
Crop
Group
13,
Berries
......................................................................
1.0
ppm
Crop
Group
15,
Cereal
Grains
(
except
corn,
rice
and
sorghum),
forage...
3.0
ppm
Crop
Group
15,
Cereal
Grains
(
except
corn,
rice
and
sorghum),
and
hay ..
.2.0
ppm
Crop
Group
15,
Cereal
Grains
(
except
corn,
rice
and
sorghum),
and
straw...
13.0
ppm
Crop
Group
15,
Cereal
Grains
(
except
corn,
rice
and
sorghum),
and
bran
 
2.5
ppm
Crop
Group
15,
Cereal
Grains
(
except
corn,
rice
and
sorghum),
and
grain
 
0.5
ppm
Carrot....................................................................................................
0.2
ppm
Corn,
forage
..........................................................................................
4.0
ppm
Corn,
grain
..........................................................................................
0.3
ppm
Corn,
stover.........................................................................................
25.0
ppm
Propiconazole
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Corn,
oil
................................................................................................
0.5
ppm
Onion,
dry
bulb
.....................................................................................
0.3
ppm
Onion,
green..........................................................................................
8.0
ppm
Pistachio................................................................................................
0.2
ppm
Rice,
bran...........................................................................................
28.0
ppm
Rice,
grain.............................................................................................
7.0
ppm
Rice,
hulls
...........................................................................................
28.0
ppm
Rice,
straw
..........................................................................................
18.0
ppm
Grain
sorghum,
forage
......................................................................
10.0
ppm
Grain
sorghum,
grain.............................................................................
2.5
ppm
Grain
sorghum,
stover
.........................................................................
15.0
ppm
Soybean,
forage...................................................................................
10.0
ppm
Soybean,
hay......................................................................................
32.0
ppm
Soybean,
seed.......................................................................................
2.0
ppm
Strawberry.............................................................................................
1.5
ppm
Sugar
beet,
dried
pulp............................................................................
2.0
ppm
Sugar
beet,
roots....................................................................................
0.3
ppm
Sugar
beet,
tops
...................................................................................
10.0
ppm
Sugar
beet,
molasses..............................................................................
3.0
ppm
Tree
nut
crop
group...............................................................................
0.2
ppm
Milk
......................................................................................................
0.1
ppm
Syngenta
has
also
submitted
petition
5F4498
for
establishing
Inadvertent/
Rotational
crop
tolerances
on
alfalfa.

Alfalfa                          
0.1
ppm
In
addition
to
Syngenta's
petition,
Interregional
Project
No.
4
(
IR­
4)
is
also
supporting
three
petitions
for
an
unrestricted
use
of
propiconazole
on
mint
(
PP#
8E4931)
and
leaf
petiole
vegetables,
subgroup
4B
(
PP#
6E4788),
and
for
the
restricted
use
of
propiconazole
on
cranberries
grown
in
WI
and
the
Pacific
Northwest
(
PP#
7E4860).
In
conjunction
with
these
petitions,
IR­
4
is
proposing
the
following
new
or
amended
tolerances:

Cranberry
..............................................................................................
1.0
ppm
Crop
Subgroup
4­
B,
Leaf
petioles
subgroup
..........................................
5.0
ppm
Mint
......................................................................................................
3.0
ppm
Propiconazole
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Table
1.
Nomenclature
of
Propiconazole
Compound
N
N
N
O
O
Cl
Cl
Common
name
Propiconazole
Company
experimental
names
CGA­
64250
IUPAC
name
1­[
2­(
2,4_
dichlorophenyl)­
4­
propyl­
1,3­
dioxolan­
2­
ylmethyl]­
1H­
1,2,4_
triazole
CAS
name
1­[[
2­(
2,4­
dichlorophenyl)­
4­
propyl­
1,3­
dioxolan­
2­
yl]
methyl]­
1H­
1,2,4­
triazole
CAS
#
60207­
90­
1
End­
use
products/
EP
3.6
lb/
gal
ECs
(
EPA
Reg.
Nos.
100­
617
and
702);
45%
WP
(
EPA
Reg.
No.
100­
780);
1.04
lb/
gal
EC
(
EPA
Reg.
No.
100­
1178,
MAI
with
azoxystrobin)

Table
2.
Physicochemical
Properties
of
Technical
Grade
Propiconazole.

Parameter
Value
Reference
Boiling
point
120
º
C
at
1.9
Pa,
>
250
º
C
at
101.325
kPa
MRID
No.
43698701
pH
4.9
at
25
º
C
(
1%
aqueous
dispersion)
MRID
No.
43698701
Density
1.289
g/
cm3
at
20
º
C
MRID
No.
43698701
Water
solubility
0.10
g/
L
at
20
º
C
MRID
No.
41720301
Solvent
solubility
(
temperature
not
specified)
Completely
miscible
in
ethanol,
acetone,
toluene
and
n­
octanol.
hexane
=
47
g/
L
MRID
No.
42030201
Vapor
pressure
4.2
x
10­
7
mm
Hg
at
25
º
C
MRID
No.
41720301
Dissociation
constant
(
pKa)
1.09
MRID
No.
43698701
Octanol/
water
partition
coefficient
Log(
KOW)
3.72
at
pH
6.6
and
25
º
C
MRID
No.
43698701
UV/
visible
absorption
spectrum
(
8max,
nm)
Not
available
MRID
No.
40583703
860.1200
Directions
for
use
There
are
currently
five
active
end­
use
products
(
EPs)
containing
propiconazole
that
are
registered
to
Syngenta
for
use
on
feed/
food
crops.
These
EPs
are
marketed
under
the
trade
names
Tilt
®
and
Orbit
 
Fungicides,
and
include:
three
3.6
lb/
gal
ECs
(
EPA
Reg.
Nos.
100­
617,
100­
702,
and
100­
737),
a
45%
WP
(
EPA
Reg.
No.
100­
780),
and
a
multiple
active
ingredient
(
MAI)
EC
formulation
containing
1.04
lb/
gal
of
propiconazole
and
0.62
lb/
gal
of
asozystrobin
(
Quilt
 
Fungicide;
EPA
Reg.
No.
100­
1178).
Proposed
or
amended
use
directions
for
these
labels
are
summarized
below
in
Table
3.
Uses
are
based
on
an
example
labels
provided
for
the
EC
formulations
(
1/
14/
05)
and
the
approved
labels
for
the
WP
(
accepted
12/
11/
03)
and
EC
MAI
(
accepted
3/
8/
06).
Propiconazole
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Table
3.
Summary
of
Directions
for
Proposed
Uses
of
Propiconazole.

Application
Timing,
Type
and
Equipment
Formulation
[
EPA
Reg.
No.]
Single
rate
(
lb
ai/
A)
Max.
#
of
Apps.
per
Season
Max.
Seasonal
Rate
(
lb
ai/
A)
PHI
(
days)
Use
Directions
and
Limitations
1
Almond
Foliar
applications
beginning
at
bud­
break
Ground
or
aerial
equipment
3.6
lb/
gal
EC
[
100­
617]
45%
WP
[
100­
780]
0.225
4
0.90
NS
Apply
in
a
minimum
of
20
or
50
gal/
A
using
aerial
and
ground
equipment,
respectively.
Minimum
RTI
is
7
days
Do
not
graze
livestock
in
treated
areas
or
cut
treated
cover
crop
for
feed
Berries
(
Bush
and
Cane
berries)
and
Cranberry
Foliar
applications
beginning
at
bud­
break
or
for
cane
berries
beginning
as
a
delayed
dormant
application
Ground
or
aerial
equipment
3.6
lb/
gal
EC
[
100­
617]
45%
WP
[
100­
780]
0.169
5
0.84
30
Apply
in
a
minimum
of
5­
10
or
20­
50
gal/
A
using
aerial
and
ground
equipment,
respectively.
The
minimum
RTI
is
7­
28
days
depending
on
the
disease.
Cranberry
(
For
use
Only
in
Wisconsin
and
the
Pacific
Northwest)
Broadcast
foliar
applications
from
bud
break
to
fruit
set
3.6
lb/
gal
EC
[
100­
702]
0.169
4
0.68
45
Minimum
RTI
is
10
days
Carrots
Broadcast
foliar
applications
when
conditions
favor
disease
development
Ground
or
aerial
equipment
3.6
lb/
gal
EC
[
100­
617]
45%
WP
[
100­
780]
0.113
4
0.45
14
Apply
in
a
minimum
of
5
or
15
gal/
A
using
aerial
and
ground
equipment,
respectively.
Minimum
RTI
is
7
days
Application
may
include
spreader­
sticker
Celery
(
Leaf
Petiole
Vegetables,
subgroup
4B)
Broadcast
foliar
applications
when
conditions
favor
disease
development
Ground
or
aerial
equipment
3.6
lb/
gal
EC
[
100­
617]
1.04
lb/
gal
EC
[
100­
1178]
45%
WP
[
100­
780]
0.113
4
0.45
14
Minimum
RTI
is
7
days
Application
may
include
spreader­
sticker
Cereals
(
wheat,
barley,
rye,
triticale
and
oats)
3.6
lb/
gal
EC
[
100­
617]
0.113
2
0.225
30/
35/
45
Do
not
apply
after
Feekes
Stage
10.5
Minimum
RTI
is
14
days.
30­
and
45­
day
PHIs
are
specified
for
forage
and
hay,
respectively,
following
an
application
at
Feekes
Stage
5.
A
general
35­
day
PHI
is
also
specified
for
grazing
or
harvest
of
forage,
hay
and
mature
wheat.
Broadcast
foliar
applications
up
to
Flowering
(
Feekes
Stage
10.5)
Aerial
or
ground
equipment,
including
chemigation
1.04
lb/
gal
EC
[
100­
1178]
0.113
2
0.167
45
Do
not
harvest
wheat
for
forage
and
do
not
graze
or
feed
livestock
treated
forage
or
cut
green
crop
of
hay
or
silage
Broadcast
foliar
applications
up
to
Feekes
Stage
8
Aerial
or
ground
equipment,
including
chemigation
45%
WP
[
100­
780]
0.113
1
0.113
40
Do
not
apply
after
Feekes
Stage
8
Do
not
apply
to
oats
with
40
days
of
harvest.
Except
for
oat
forage
and
hay,
do
not
graze
or
feed
livestock
treated
forage
or
cut
the
green
crop
for
hay
or
silage
Corn
(
field,
seed,
pop
and
sweet)
Broadcast
foliar
applications
when
conditions
favor
disease
development
Aerial
or
ground
equipment,
including
chemigation
3.6
lb/
gal
EC
[
100­
617]
45%
WP
[
100­
780]
0.113
4
0.45
14/
30
Minimum
RTI
is
7
days.
A
14­
day
PHI
is
specified
for
sweet
corn
forage
and
ears,
and
a
30­
day
PHI
is
specified
for
forage,
grain
and
stover
of
field,
pop,
and
seed
corn.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
12
of
63
Table
3.
Summary
of
Directions
for
Proposed
Uses
of
Propiconazole.

Application
Timing,
Type
and
Equipment
Formulation
[
EPA
Reg.
No.]
Single
rate
(
lb
ai/
A)
Max.
#
of
Apps.
per
Season
Max.
Seasonal
Rate
(
lb
ai/
A)
PHI
(
days)
Use
Directions
and
Limitations
1
Dry
Beans
and
Peas
Broadcast
foliar
applications
when
conditions
favor
disease
development
Aerial
or
ground
equipment
3.6
lb/
gal
EC
[
100­
617]
45%
WP
[
100­
780]
0.113
3
0.338
14
Do
not
apply
to
succulent
bean
varieties
Apply
in
a
minimum
of
5
or
15
gal/
A
using
aerial
and
ground
equipment,
respectively.
Minimum
RTI
is
14
days
Filberts
(
Hazelnuts)
Foliar
applications
beginning
at
bud
break
Aerial
or
ground
equipment
3.6
lb/
gal
EC
[
100­
617]
0.225
4
0.90
NS
For
aerial
applications,
minimum
volumes
of
5­
10
or
20
gal/
A
are
recommended.
For
ground
applications,
minimum
volumes
of
10­
50
or
100
gal/
A
are
recommended.
Minimum
RTI
is
14
days
Do
not
graze
livestock
in
treated
areas
or
cut
treated
cover
crop
for
feed
Onions
(
green,
dry
bulb,
or
seed
crop)
2
Broadcast
foliar
applications
when
conditions
favor
disease
development
Aerial
or
ground
equipment
3.6
lb/
gal
EC
[
100­
617]
45%
WP
[
100­
780]
0.225
2
0.45
0
3/
14
Apply
in
a
minimum
of
5
or
15
gal/
A
using
aerial
and
ground
equipment,
respectively.
Minimum
RTI
is
7
days
PHIs
are
0
for
green
onions
and
14
days
for
dry
bulb
onions
Peppermint
and
Spearmint
Broadcast
foliar
applications
beginning
when
plants
are
2­
4
inches
in
height
Equipment
not
specified
3.6
lb/
gal
EC
[
100­
617]
0.113
2
0.225
30
Apply
in
a
minimum
of
20
gal/
A
Minimum
RTI
is
10
days
Pecans
Foliar
applications
beginning
at
emergence
of
green
leaves
Aerial
or
ground
equipment
3.6
lb/
gal
EC
[
100­
617]
[
100­
702]
1.04
lb/
gal
EC
[
100­
1178]
45%
WP
[
100­
780]
0.225
4
0.90
NS
Apply
in
a
minimum
of
20
gal/
A
for
aerial
applications
Minimum
RTI
is
14
days,
Do
not
apply
after
shuck
split
The
label
for
100­
1178
also
specifies
a
45­
day
PHI
Do
not
graze
livestock
in
treated
areas
or
cut
treated
cover
crop
for
feed
Pistachios
Foliar
applications
beginning
at
emergence
of
green
leaves
Aerial
or
ground
equipment
3.6
lb/
gal
EC
[
100­
617]
45%
WP
[
100­
780]
0.225
4
0.90
NS
Apply
in
a
minimum
of
20
gal/
A
for
aerial
applications
and
50­
100
gal/
A
for
ground
applications
Minimum
RTI
is
14
days
Do
not
graze
livestock
in
treated
areas
or
cut
treated
cover
crop
for
feed
Rice
(
Do
not
use
in
CA)

0.28
1
Broadcast
foliar
application(
s)
after
tillering
Ground
or
aerial
equipment
3.6
lb/
gal
EC
[
100­
617]
1.04
lb/
gal
EC
[
100­
1178]
45%
WP
[
100­
780]

0.169
2
0.338
35
Apply
aerially
in
a
minimum
of
5­
20
gal/
A.
Minimum
RTI
is
10
days
The
label
for
the
1.04
lb/
gal
EC
prohibits
applications
after
head
emergence.
Do
not
apply
to
stubble
or
ratoon
crop.
Do
not
use
in
rice
fields
where
crayfish
farming
will
be
practiced
or
drain
water
from
treated
fields
into
ponds
used
for
crayfish
farming.
Do
not
use
water
drained
from
treated
fields
to
irrigate
other
crops
water
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
13
of
63
Table
3.
Summary
of
Directions
for
Proposed
Uses
of
Propiconazole.

Application
Timing,
Type
and
Equipment
Formulation
[
EPA
Reg.
No.]
Single
rate
(
lb
ai/
A)
Max.
#
of
Apps.
per
Season
Max.
Seasonal
Rate
(
lb
ai/
A)
PHI
(
days)
Use
Directions
and
Limitations
1
Sorghum
Broadcast
foliar
applications
beginning
at
or
just
prior
to
flowering
Aerial
or
ground
equipment
3.6
lb/
gal
EC
[
100­
617]
45%
WP
[
100­
780]
0.113
4
0.45
21/
30
Apply
in
a
minimum
of
5
or
15
gal/
A
using
aerial
and
ground
equipment,
respectively.
PHIs
are
30
days
for
forage
and
21
days
for
grain
and
stover
Minimum
RTI
is
5
days
Soybeans
Broadcast
foliar
applications
beginning
at
first
appearance
of
disease
until
to
pod
fill
(
Stage
R5)
Ground
and
aerial
equipment
3.6
lb/
gal
EC
[
100­
617]
1.04
lb/
gal
EC
[
100­
1178]
45%
WP
[
100­
780]
0.169
2
0.338
30
Apply
in
a
minimum
of
5
and
15
gal/
A
using
aerial
and
ground
equipment,
respectively.
Minimum
RTI
is
14
days
Do
not
graze
or
feed
soybean
forage
or
hay
Strawberries
Broadcast
foliar
applications
before
disease
levels
reach
5%
Aerial
or
ground
equipment
3.6
lb/
gal
EC
[
100­
617]
45%
WP
[
100­
780]
0.113
4
0.45
0
Apply
in
a
minimum
of
5
or
15
gal/
A
using
aerial
and
ground
equipment,
respectively.
Minimum
RTI
is
7
days
Sugar
beets
Broadcast
foliar
applications
beginning
at
first
appearance
of
disease
Equipment
not
specified
3.6
lb/
gal
EC
[
100­
617]
45%
WP
[
100­
780]
0.113
3
0.338
21
Minimum
RTI
is
10
days
Tree
Nut
Crops
Foliar
application
at
unspecified
timing
Ground
and
aerial
equipment
3.6
lb/
gal
EC
[
100­
617]
45%
WP
[
100­
780]
0.225
4
0.90
60
Apply
in
a
minimum
of
20
for
aerial
applications,
or
50­
100
gal/
A
for
ground
applications.
Minimum
RTI
is
not
specified.

1
Labels
include
a
24­
hour
restricted
entry
interval.
Under
general
use
directions,
the
following
rotational
crop
restriction
is
listed:
do
not
replant
within
105
days
of
propiconazole
application
to
preceding
crop,
unless
the
second
crop
appears
on
the
label.
In
addition,
minimum
application
volumes
are
5
and
10
gal/
A
for
aerial
and
ground
applications,
respectively,
unless
otherwise
specified.
For
specified
crops,
ground
applications
may
include
chemigation
through
center
pivot,
solid
set,
hand
move,
or
moving
wheel
irrigation.
2
Use
on
dry
bulb
onions
includes
garlic,
dry
bulb
onions
and
dry
bulb
shallots,
and
the
use
on
green
onions
includes
green
onions,
leeks,
spring
onions
or
scallions,
Japanese
bunching
onions,
green
shallots,
and
green
eschalots.
3
For
crops
with
0­
day
PHIs
(
green
onions
and
strawberry),
entry
within
the
24­
hour
REI
requires
use
of
PPE.
RTI
=
retreatment
interval
NS
=
not
specified.

°
Use
directions
for
tree
nuts
(
almonds,
filberts,
and
pistachios)
should
be
amended
to
specify
a
minimum
PHI
of
60
days,
with
the
exception
of
pecans.
A
specific
PHI
is
not
required
for
pecans
as
applications
to
pecans
are
prohibited
after
shuck
split,
and
the
available
pecan
field
trial
data
support
applications
up
to
shuck
split,
which
is
a
distinct
growth
stage.
The
available
almond
and
pecan
field
trial
data
support
minimum
RTIs
of
7
or
14
days
and
concentrated
or
dilute
application
volumes.
The
use
directions
for
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
14
of
63
filberts
must
be
clarified
to
list
single
minimum
volumes
for
ground
and
aerial
applications.

°
Use
directions
for
cranberry
should
be
separated
from
directions
for
other
berries
on
all
labels.
The
available
cranberry
residue
data
support
up
to
four
foliar
applications
of
propiconazole
at
0.169
lb
ai/
A/
application,
from
bud­
break
through
early
fruit
development,
at
minimum
RTIs
of
14
days,
for
a
maximum
of
0.68
lb
ai/
A/
season,
with
45­
day
PHI.
The
use
on
cranberries
should
be
restricted
to
Regions
5
and
12.

°
Use
directions
should
be
standardized
between
wheat,
barley,
rye,
triticale
and
oats.
The
available
wheat
field
trial
data
will
support
applications
to
these
cereal
grains
at
up
to
Feekes
Growth
Stage
10.5
at
a
rate
of
0.11
lb
ai/
A/
application,
for
a
maximum
of
0.22
lb
ai/
A/
season.
The
data
support
a
minimum
RTI
of
14
days
and
PHIs
of
30
days
for
forage,
45
days
for
hay,
and
40
days
for
grain
and
straw.
In
addition,
the
available
field
trial
data
will
only
support
application(
s)
at
up
to
0.11
lb
ai/
A
prior
to
the
harvest
of
forage
or
hay.
Unless
the
petitioner
intends
to
provide
additional
data
on
forage
and
hay
supporting
use
of
rates
up
to
0.22
lb
ai/
A,
the
labels
should
be
amended
to
specify
a
maximum
total
application
rate
of
0.11
lb
ai/
A
on
wheat,
barley,
oats
or
rye
harvested
for
forage
or
hay.

°
For
both
field
corn
and
sorghum,
the
available
field
trial
data
will
only
support
applications
totaling
0.22
lb
ai/
A
prior
to
the
harvest
of
forage.
Labels
should
be
amended
to
specify
a
maximum
total
application
rate
of
0.22
lb
ai/
A
on
field
corn
and
sorghum
harvested
for
forage.

°
For
dry
peas
and
beans,
delete
these
uses.

°
The
minimum
RTI
for
applications
to
mint
should
be
changed
from
10
to
14
days,
and
the
use
directions
should
specify
the
types
of
application
equipment
allowed
(
ground
and/
or
aerial).

°
Base
on
the
rice
field
trial
data,
the
minimum
RTI
for
spilt
applications
to
rice
should
be
changed
from
10
to
14
days.

°
Although
label
directions
for
soybeans
prohibit
the
feeding
or
grazing
of
forage
or
hay,
tolerances
have
been
proposed
for
soybean
forage
and
hay
and
adequate
data
are
available
for
these
commodities.
Therefore,
this
feeding
restriction
can
be
removed
from
the
label.

°
The
available
strawberry
field
trial
data
support
a
minimum
application
volume
of
50
gal/
A
rather
than
5
gal/
A.

°
Base
on
the
available
alfalfa
rotational
crop
data,
labels
can
be
amended
to
include
at
75­
day
plant­
back
interval
for
the
rotation
of
alfalfa
following
primary
crops
treated
with
up
to
a
total
seasonal
rate
of
0.22
lb
ai/
A
of
propiconazole.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
15
of
63
860.1300
Nature
of
the
Residue
 
Plants.

Propiconazole
RED,
DP
Barcode
D329394,
Y.
Donovan,
6/
15/
06
45206201.
der
(
carrot
metabolism)

The
nature
of
propiconazole
residues
in
plants
is
adequately
understood.
Initial
metabolism
studies
on
peanuts,
wheat,
grapes
and
rice
were
summarized
in
the
Phase
4
Review
and
indicated
that
the
metabolite
profile
was
similar
in
both
the
primary
and
rotational
crops;
however,
complete
quantitative
data
were
not
available
from
these
studies.
Additional
studies
have
since
been
conducted
on
celery,
wheat,
and
carrots
that
were
deemed
completely
adequate.
Together
these
data
indicate
that
the
major
metabolic
pathway
in
plants
appears
to
involve
hydroxylation
of
the
n­
propyl
group
on
the
dioxolane
ring
of
the
cis/
trans
isomers
of
propiconazole,
with
subsequent
conjugation
to
sugars.
A
possible
alternative
pathway
involves
reductive
deketalization
of
the
dioxolane
ring
and
sugar
conjugation
of
the
resulting
metabolite.
The
alkyl
bridge
between
the
phenyl
and
triazole
rings
is
metabolized
and
free
1H­
1,2,4­
triazole
is
released.
The
free
triazole
is
readily
conjugated
with
the
amino
acid,
serine/
alanine,
forming
triazole
aniline
which
is
further
metabolized
to
triazole
acetic
acid
possibly
through
the
intermediate
formation
of
triazole
lactic
acid.
The
free
triazole,
triazole
alanine,
and
triazole
acetic
acid
are
also
residues
of
concern.
Since
these
are
common
metabolites
from
several
triazole
containing
pesticides,
the
risk
assessment
for
triazoles
has
been
assessed
separately
(
HED
memo
of
2/
7/
06,
M.
Doherty,
D322215).
The
cited
assessment
included
all
the
proposed
propiconazole
new
uses
in
the
subject
petitions.

Based
on
these
studies,
HED
concluded
that
the
residues
of
concern
for
dietary
risk
assessment
(
food)
should
include
propiconazole
and
all
its
metabolites
containing
the
2,4­
DCBA
moiety,
including
conjugates,
as
virtually
all
the
residue
data
have
been
generated
using
a
common
moiety
method
that
converts
parent
and
all
of
the
metabolites
of
concern
to
2,4­
DCBA.
However,
only
residues
of
propiconazole
per
se
should
be
included
in
water
for
purposes
of
the
dietary
risk
assessment.
The
tolerance
expression
should
also
be
amended
to
include
only
propiconazole
per
se
because
1)
there
are
a
number
of
pesticides
that
have
2,4­
DCBA
as
common
metabolite,
and
an
enforcement
agency
may
not
be
able
to
determine
if
residues
are
due
to
misuse
of
propiconazole
or
the
proper
use
of
other
pesticides
containing
2,4­
DCBA;
2)
propiconazole
per
se
can
be
detected
by
FDA
multiresidue
methods;
and
3)
inclusion
of
only
parent
allows
harmonization
with
the
residue
definition
for
the
Codex
MRLs.
Although
HED
also
considers
free
triazole
to
be
a
residue
of
concern
in
plants,
issues
pertaining
to
triazole
residues
are
addressed
in
a
separate
document.

860.1300
Nature
of
the
Residue
 
Livestock.

Propiconazole
RED,
DP
Barcode
D329394,
Y.
Donovan,
6/
15/
06
The
nature
of
propiconazole
residues
in
livestock
is
adequately
understood
based
on
the
acceptable
goat
and
poultry
metabolism
studies.
In
one
ruminant
study,
three
lactating
goats
received
[
phenyl­
14C]
propiconazole
at
67­
92
ppm
for
four
consecutive
days
in
the
feed.
The
dosing
levels
correspond
to
1.7­
2.3x
the
MTDB
for
dairy
cattle.
The
parent
(
1.7­
13.9%
TRR),
and
metabolites
CGA­
118244
(
9.4­
34%
TRR),
and
CGA­
91305
(
15.9­
31.3%
TRR)
were
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
16
of
63
identified
in
the
organic
extract
of
tissues;
metabolites
CGA­
118244
(
23%
TRR)
and
CGA­
91305
(
24%
TRR)
were
also
identified
in
milk.
In
addition,
an
unknown
was
quantified
(
6.2­
31.1%
TRR)
in
goat
tissues.
In
a
second
ruminant
study,
a
single
goat
was
fed
[
triazole­
14C]
propiconazole
at
4.53
ppm
(
0.1x)
for
10
days.
The
TRR
in
tissues
and
milk
ranged
from
0.01
ppm
in
muscle
to
0.96
ppm
in
liver;
TRR
in
milk
were
0.015
ppm.
On
further
analysis
of
subsamples
of
milk
and
liver,
sulfate
and
glucuronide
conjugates
were
found
in
milk,
and
conjugation
with
amino
acids
was
suggested
in
liver;
propiconazole
per
se
was
not
identified
in
milk
or
liver.

In
the
poultry
study,
four
laying
hens
received
[
phenyl­
14C]
propiconazole
at
67
ppm
for
eight
consecutive
days
in
feed.
The
dosing
level
corresponds
to
7.3x
MTDB
for
poultry.
The
parent
(
1.4­
39.0%
TRR),
and
metabolites
CGA­
118244
(
1.5­
50.0%
TRR),
and
CGA­
91305
(
17.7­
78.6%
TRR)
were
identified
in
the
organic
extracts
of
tissues
and
eggs.

The
Agency
concluded
that
parent
and
all
metabolites
convertible
to
2,4­
DCBA
are
residues
of
concern
for
risk
assessment,
as
the
analytical
method
is
a
common
moiety
method
that
detects
all
residues
convertible
to
2,4­
DCBA.
However,
for
tolerance
enforcement
purposes,
the
current
tolerance
expression
should
be
amended
to
include
only
propiconazole
per
se.

860.1340
Residue
Analytical
Methods.

Propiconazole
RED,
DP
Barcode
D329394,
Y.
Donovan,
6/
15/
06
Plant
commodities:
Samples
from
the
various
field
trials
and
processing
studies
supporting
the
current
petitions
were
analyzed
for
combined
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
using
GC/
ECD
Methods
AG­
454B
and
AG­
626,
which
are
more
recent
versions
of
the
original
tolerance
enforcement
method
(
AG­
454).
Samples
from
two
of
the
cranberry
field
trials
used
a
modification
to
AG­
454,
in
which
a
nitrogen­
phosphorus
detector
(
NPD)
was
used
instead
of
the
ECD.
All
of
these
methods
are
similar
common
moiety
methods
in
which
residues
are
converted
by
base
hydrolysis
and
oxidation
to
2,4­
DCBA,
then
determined
as
the
2,4­
DCBA
methyl
ester,
and
reported
in
propiconazole
equivalents
using
a
conversion
factor
of
1.79.
With
the
exception
of
almond
hulls,
which
had
a
LOQ
of
0.1
ppm,
the
validated
LOQ
for
combined
residues
was
0.05
ppm
in
all
raw
and
processed
commodities.
Each
of
the
methods
was
validated
in
conjunction
with
the
field
trials
and
processing
studies,
and
acceptable
concurrent
method
recoveries
were
obtained
for
all
crop
matrices.

In
addition
to
determining
combined
residues,
samples
from
one
of
the
wheat
field
trials
and
processing
studies
were
also
analyzed
for
residues
of
propiconazole,
per
se,
using
a
GC/
NPD
method
from
PAM
Vol.
I
(
Method
302
E4
+
DG5).
This
method
was
also
adequately
validated
in
conjunction
with
the
analysis
of
field
trial
samples,
and
the
validated
LOQ
was
0.05
ppm.

In
the
majority
of
field
trials
and
processing
studies
submitted
for
these
petitions,
the
petitioner
reported
corrected
residue
values
for
samples
with
procedural
recoveries
of
<
100%.
However,
when
available,
uncorrected
residue
data
are
reported
in
this
review
and
were
used
in
determining
tolerance
levels.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
17
of
63
For
enforcement
purposes,
residue
Method
AG­
354
is
available
for
determining
propiconazole
per
se
in/
on
plant
commodities
using
gas
chromatography
and
flame
ionization
detection,
and
the
reported
LOQ
is
0.05
ppm.
In
addition,
Multiresidue
Methods
Section
302
can
also
be
used
to
detect
parent
propiconazole.

Animal
commodities:
GC/
ECD
Methods
AG­
517
and
AG­
629
(
a
modification
of
method
AG­
517)
are
available
for
determining
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
in
animal
commodities.
These
methods
use
a
single
moiety
detection
in
which
residues
are
converted
to
2,4­
DCBA,
determined
as
the
2,4­
DCBA
methyl
ester,
and
reported
as
propiconazole
equivalents
using
a
conversion
factor
of
1.79.
The
method
LOQ
is
0.05
ppm
for
residues
in
meat,
poultry,
and
eggs
and
0.02
ppm
for
residues
in
milk.
Samples
from
the
ruminant
and
poultry
feeding
studies
were
analyzed
using
method
AG­
359
(
an
early
version
of
method
AG­
517)
and
method
AG­
517.
For
enforcement
purpose,
the
Multiresidue
Methods
Section
302
(
Luke
Method;
Protocol
D)
will
detect
residues
of
parent
propiconazole.

GLN
860.1360:
Multiresidue
Methods
The
FDA
PESTDATA
database
(
PAM
Volume
I,
Appendix
I)
indicates
that
propiconazole
is
completely
recovered
(>
80%)
using
Multiresidue
Methods
Section
302.
The
recovery
of
propiconazole
metabolites
CGA­
91305,
CGA­
118244,
and
1,2,4­
triazole
is
variable
using
Section
302.
Propiconazole
and
metabolites
CGA­
91305,
CGA­
118244,
and
1,2,4­
triazole
are
not
recovered
using
Multiresidue
Methods
Sections
303
and
304.

860.1380
Storage
Stability.

Propiconazole
RED,
DP
Barcode
D329394,
Y.
Donovan,
6/
15/
06
Adequate
storage
stability
data
are
available
indicating
that
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
DCBA
are
stable
at
 ­
15
º
C
for
up
to
36
months
in
peaches,
bananas,
corn
meal,
wheat
grain,
celery,
corn
oil,
and
peanut
nutmeat,
hay,
and
hulls;
10
months
in
carrots;
and
4­
6
months
in
soybean
seed
and
fodder.
Weathered
residues
of
propiconazole
and
its
metabolites
were
also
found
to
be
stable
under
frozen
storage
conditions
in
grass
forage,
straw,
and
seed
for
up
to
39
months
at
­
20
º
C;
wild
rice
and
stone
fruits
for
up
to
25
months;
peanut
hulls
and
fodder
for
25
months
at
­
15
º
C;
and
in
extracts
of
silage­
stage
corn
forage
and
soybeans
for
3
and
8
months,
respectively,
at
4
º
C.
These
storage
stability
data
are
adequate
to
validate
the
storage
intervals
and
conditions
of
samples
collected
from
the
current
field
and
processing
studies.
In
cases
where
existing
storage
stability
data
are
not
available,
concurrent
storage
stability
data
were
submitted
along
with
field
trials
and
/
or
processing
studies.

Adequate
Storage
stability
data
are
also
available
on
animal
commodities
to
support
the
existing
livestock
feeding
studies.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
18
of
63
860.1400
Water,
Fish,
and
Irrigated
Crops
With
the
exception
of
rice,
propiconazole
is
not
registered
for
direct
use
on
water
and
aquatic
food
and
feed
crops.
Although
propiconazole
is
registered
for
use
on
rice,
current
label
restrictions
prohibit
the
use
on
rice
in
CA
(
where
typical
agricultural
practices
for
rice
field
irrigation
entail
a
"
flow­
through"
system);
typical
agricultural
practices
concerning
rice
field
irrigation
in
all
other
areas
allow
for
the
on­
site
evaporation
of
waters
used
in
rice
fields.
Label
restrictions
preclude
the
use
of
water
drained
from
treated
rice
fields
to
irrigate
other
crops.
Label
restrictions
also
preclude
use
where
catfish
and
crayfish
are
produced.
Therefore,
no
residue
chemistry
data
are
required
under
these
guideline
topics.

860.1460
Food
Handling
This
guideline
requirement
is
not
relevant
to
the
current
petition
as
no
food
handling
uses
are
being
proposed
for
propiconazole.

860.1480
Meat,
Milk,
Poultry,
and
Eggs
Propiconazole
RED,
DP
Barcode
D329394,
Y.
Donovan,
6/
15/
06
The
maximum
theoretical
dietary
burdens
(
MTDB)
for
combined
propiconazole
residues
were
calculated
to
be
29.0
ppm
for
beef
and
18.5ppm
for
dairy
cattle,
2.3
ppm
for
swine
and
2.0
ppm
for
poultry.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
19
of
63
Table
4.
Calculation
of
Maximum
Dietary
Burdens
of
Livestock
for
Propiconazole
Residues.

Feed
Commodity
%
Dry
Matter
1
%
Diet
1
Current
or
Recommended
Tolerance
(
ppm)
Dietary
Contribution
(
ppm)
2
Beef
Cattle
Grass,
hay
[
R]
88
50
40
22.7
Corn
field,
grain
[
CC]
88
20
0.3
0.07
Rice,
bran
[
R]
88
10
28
3.2
Aspirated
grain
fractions
[
CC]
85
5
45
2.65
Soybean
seed
[
PC]
89
15
2.0
0.34
TOTAL
100
29.0
Dairy
Cattle
Grass,
hay
[
R}
88
30
40
13.6
Corn,
field,
stover
[
R]
83
15
25.0
4.52
Corn,
field,
grain
[
CC]
88
40
0.3
0.14
Soybean
seed
[
PC]
89
15
2.0
0.34
TOTAL
100
18.5
Poultry
Wheat
grain
[
CC]
89
60
0.5
0.34
Rice,
grain
[
CC]
88
20
7.0
1.6
Soybean,
seed
[
PC]
89
20
2.0
0.45
TOTAL
100
2.0
Swine
Corn
field,
grain
[
CC]
88
60
0.3
0.20
Rice,
grain
[
CC]
88
20
7.0
1.6
Soybean,
seed
[
PC]
89
20
2.0
0.45
TOTAL
100
2.3
1
Table
1
(
OPPTS
Guideline
860.1000).
2
Contribution
=
([
tolerance
/%
DM]
X
%
diet)
for
beef
and
dairy
cattle;
contribution
=
([
tolerance]
X
%
diet)
for
poultry
and
swine.
NA
=
not
applicable.

An
adequate
dairy
cattle
feeding
study
is
available
reflecting
dosing
with
propiconazole
at
levels
equivalent
to
15,
75,
and
150
ppm
in
the
diet
for
periods
up
to
14,
21
and
28
days.
Samples
of
milk
were
collected
daily
and
tissues
samples
were
collected
at
study
termination.
Combined
propiconazole
residues,
determined
as
2,4­
DCBA
and
expressed
in
parent
equivalents,
were
determined
using
an
adequate
GC/
FID
method
(
AG­
359)
and
an
adequate
GC/
ECD
method
(
AG­
517).
Combined
propiconazole
residues
in
cattle
tissues
are
summarized
below
in
Table
5.
For
milk,
combined
residues
were
nondetectable
(<
0.01
ppm)
at
the
15­
ppm
dose
level
and
were
detected
at
0.10
and
0.11
ppm
at
the
75­
and
150­
ppm
dosing
levels,
respectively.

An
adequate
laying
hen
feeding
study
is
also
available
reflecting
dosing
with
propiconazole
at
levels
equivalent
to
7.5,
37.5,
and
75
ppm
in
the
diet
for
periods
up
to
14,
21
and
28
days.
Samples
of
eggs
were
collected
daily
and
tissues
samples
were
collected
at
study
termination.
Combined
propiconazole
residues,
determined
as
2,4­
DCBA
and
expressed
in
parent
equivalents,
were
determined
using
an
adequate
GC/
FID
method
(
AG­
359)
and
an
adequate
GC/
ECD
method
(
AG­
517).
Combined
propiconazole
residues
in
poultry
tissues
are
summarized
below
in
Table
6.
For
whole
eggs,
combined
residues
were
nondetectable
(<
0.05
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
20
of
63
ppm)
at
the
7.5­
ppm
feeding
level
and
were
detected
at
0.18
and
0.37
ppm
at
the
37.5­
and
175­
ppm
feeding
levels
respectively.

Table
5.
Total
Combined
Propiconazole
Residues
in
Dairy
Cattle
Tissues
From
Feeding
Studies
Conducted
at
Dosing
Levels
Equivalent
to
15,
75,
and
150
ppm
in
the
Diet
(
0.4x,
1.9x,
and
3.8x
MTDB).
1
Dosing
Duration
14
days
21
days
28
days
Dosing
Level
(
ppm)
15
75
150
15
75
150
15
75
150
Muscle
<
0.05
0.11
0.18
<
0.05
0.08
2
0.13
<
0.05
0.05
0.11
Kidney
0.61
3.04
6.48
0.56
4.68
2
5.0
0.63
3.68
5.50
Liver
0.5
4.0
4.6
0.81
4.3
2
5.3
0.57
2.7
5.6
Fat
<
0.05
0.23
0.26
<
0.05
0.15
2
0.19
<
0.05
0.08
0.17
1
Data
were
obtained
from
Propiconazole
RED,
Y.
Donovan,
6/
15/
06.
2
Residue
values
in
shaded
cells
were
used
to
calculate
maximum
potential
combined
residues
in
ruminants
and
swine
at
1x
feeding
level.

Table
6.
Total
Combined
Propiconazole
Residues
in
Hen
Tissues
From
Feeding
Studies
Conducted
at
Dosing
Levels
Equivalent
to
7.5,
37.5,
and
75
ppm
in
the
Diet
(
0.8x,
4.1x,
and
8.2x
MTDB).
1
Dosing
Duration
14
days
21
days
28
days
Dosing
Level
(
ppm)
7.5
37.5
75
7.5
37.5
75
7.5
37.5
75
Muscle
<
0.05
<
0.05
<
0.05
<
0.05
<
0.05
0.07
2
<
0.05
<
0.05
0.06
Liver
<
0.1
0.10
0.47
2
<
0.05
0.08
0.39
0.1
0.16
0.30
Fat
<
0.05
<
0.05
0.11
2
<
0.05
<
0.05
0.06
<
0.05
<
0.05
0.05
1
Data
were
obtained
from
Propiconazole
RED,
Y.
Donovan,
6/
15/
06.
2
Residue
values
in
shaded
cells
were
used
to
calculate
maximum
potential
combined
residues
in
poultry
at
1x
feeding
level.

To
estimate
maximum
combined
residues
in
cattle
and
swine
commodities,
the
residue
levels
for
the
75­
ppm
feeding
level
at
21
days
were
selected
as
these
residue
levels
were
the
highest
for
the
75­
ppm
group.
This
feeding
level
represents
a
2.7x
the
MTDBs
for
beef
cattle,
4.2x
for
dairy
cattle,
and
a
32.6x
for
swine.
Maximum
combined
residues
were
estimated
by
dividing
the
residue
values
for
milk
and
tissues
at
the
75­
ppm
dose
level
by
2.7
for
cattle,
4.2
for
milk,
and
32.6
for
swine.
For
beef
cattle,
estimated
combined
residues
at
a
1x
feeding
level
are
1.7
ppm
for
kidney,
1.6
ppm
for
liver,
0.03
ppm
for
muscle,
0.05
ppm
for
fat,
and
0.03
pm
for
milk.
For
swine,
estimated
combined
residues
at
a
1x
feeding
level
are
0.14ppm
for
kidney,
0.13
ppm
for
liver
and
<
0.005
ppm
for
muscle
and
fat.
HED
recommends
that
the
following
tolerance
levels
be
established:
For
cattle,
goat,
horses
and
sheep,
kidney
and
liver
at
2.0
ppm;
meat
and
meat
byproduct
(
except
kidney
and
liver)
and
fat
at
0.05
ppm,
milk
at
0.05
ppm.
For
hog,
kidney
and
liver
at
0.20
ppm,
no
tolerances
are
needed
for
meat,
fat,
and
meat
byproduct.

For
poultry
tissues
and
eggs,
estimated
combined
residues
and
parent
residues
were
calculated
in
the
same
manner
as
for
cattle
and
swine.
The
maximum
combined
residues
in
tissues
and
eggs
from
the
7.5­
ppm
dose
group
in
the
poultry
feeding
study
were
used
to
estimate
residues
at
the
1x
feeding
level.
The
estimated
combined
residues
at
the
1x
feeding
level
are
all
<
LOQ.
Therefore,
tolerances
for
poultry
tissues
and
eggs
are
not
required
as
quantifiable
levels
of
propiconazole
are
unlikely
to
occur
in
these
commodities
[
40
CFR
180.6(
a)(
3)].

860.1500
Crop
Field
Trials
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
21
of
63
43655612.
der
(
corn)
44757207.
der1
(
sugar
beet)
45080809.
der
(
corn)
43655613.
der
(
celery)
44757208.
der1
(
wheat)
45050811.
der1
(
rice)
44338101.
der
(
cranberry)
44757210.
der
(
almond)
45275801.
der
(
sorghum)
44416501.
der
(
mint)
45080807.
der
(
sugar
beet)
45542401.
der
(
strawberry)
46473001.
der
(
soybean)
46576301.
der
(
soybean)

Syngenta
and
IR­
4
have
submitted
field
trials
supporting
new
or
amended
uses
for
propiconazole
(
EC
and/
or
WP)
on
almonds,
celery,
field
and
pop
corn,
cranberry,
mint,
rice,
sorghum,
soybeans,
strawberries,
sugar
beets
and
wheat.
The
results
from
these
studies
are
discussed
below
and
summarized
in
Table
7.
In
addition,
previously
reviewed
field
trial
data
on
berries,
beans
(
dry),
carrots,
celery,
onions,
soybeans,
and
tree
nuts
are
also
summarized
below.

Table
7.
Summary
of
Residue
Data
from
Crop
Field
Trials
with
Propiconazole
(
EC
and/
or
WP).
Combined
Residues
(
ppm)
1
Crop/
Commodity
MRID#
Total
Appl.
Rate
(
lb
ai/
A)
End­
use
Product
PHI
(
days)
n
Min.
Max.
HAFT2
Median
3
(
STMdR)
Mean
3
(
STMR)
Std.
Dev.

Almonds
(
0.90
lb
ai/
A
total
application
rate,
60­
day
PHI)
45%
WP
12
<
0.05
0.07
0.07
0.025
0.035
0.018
Nutmeats
3.6
lb/
gal
EC
53­
63
12
<
0.05
0.09
0.08
0.025
0.041
0.024
45%
WP
12
0.57
4.60
4.45
1.20
1.78
1.36
Hull
44757210
&
45215806
0.88­
0.91
(
1x)
4
3.6
lb/
gal
EC
53­
63
12
0.67
4.20
4.00
1.85
2.06
1.06
Dry
Beans
(
0.34
lb
ai/
A
total
application
rate,
14­
day
PHI)
Vines
7
10
1.20
7.50
6.20
2.10
3.11
2.17
Hay
23­
28
10
0.17
4.90
4.85
1.70
2.11
1.68
Beans
0.41
(
1.2x)
23­
31
10
<
0.05
0.13
0.12
0.08
0.08
0.04
Vines
7
3
1.90
9.90
9.90
4.70
5.50
4.06
Hay
25­
28
3
1.10
15.0
15.0
1.80
5.97
7.83
Beans
43386501
0.83
(
2.5x)
3.6
lb/
gal
EC
25­
28
3
<
0.05
0.10
0.10
0.10
0.08
0.04
Berry
Crop
Group
(
0.84
lb
ai/
A
total
application
rate,
30­
day
PHI)
Bush
and
Cane
berries
43786403
0.85
(
1x)
3.6
lb/
gal
EC
30
12
0.14
0.66
0.62
0.35
0.36
0.16
Carrot
(
0.45
lb
ai/
A
total
application
rate,
14­
day
PHI)

Roots
43786402
0.44
(
1x)
3.6
lb/
gal
EC
13­
14
14
<
0.05
0.17
0.16
0.10
0.10
0.003
Celery
(
0.45
lb
ai/
A
total
application
rate,
14­
day
PHI)

40783301
0.44­
0.55
(
1­
1.3x)
3.6
lb/
gal
EC
14
20
0.27
4.98
4.98
0.60
1.13
1.28
3.6
lb/
gal
EC
14
2
0.27
0.42
0.35
0.35
0.35
0.11
Untrimmed
stalks
43655613
0.44
(
1x)
45%
WP
14
2
0.43
0.51
0.47
0.47
0.47
0.06
Corn,
field
and
pop
(
0.45
lb
ai/
A
total
application
rate,
30­
day
PHI)
Forage
0.22
(
0.5x)
29­
32
36
<
0.05
1.90
1.45
0.36
0.45
0.49
Stover
48
0.92
19.60
15.9
5.65
6.87
4.75
Grain
45080809
&
45080810
0.42­
0.47
(
1x)
1.04
lb/
gal
EC
28­
35
48
<
0.05
0.15
0.10
0.025
0.037
0.024
3.6
lb/
gal
EC
4
<
0.05
1.26
1.18
0.56
0.60
0.67
Forage
0.44
(
1x)
45%
WP
30­
31
4
<
0.05
1.66
1.42
0.64
0.74
0.81
3.6
lb/
gal
EC
4
<
0.05
2.15
1.93
0.87
0.98
1.11
Stover
0.44
(
1x)
45%
WP
93­
118
4
<
0.05
2.51
2.35
1.13
1.20
1.34
3.6
lb/
gal
EC
4
<
0.05
<
0.05
<
0.05
0.025
0.025
0.00
Grain
43655613
0.44
(
1x)
45%
WP
93­
118
4
<
0.05
<
0.05
<
0.05
0.025
0.025
0.00
Cranberry
(
0.68
lb
ai/
A
total
application
rate,
45­
day
PHI)
Cranberry
44338101
0.66­
0.68
3.6
lb/
gal
43­
44
6
0.18
0.59
0.53
0.23
0.32
0.17
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
22
of
63
Table
7.
Summary
of
Residue
Data
from
Crop
Field
Trials
with
Propiconazole
(
EC
and/
or
WP).
Combined
Residues
(
ppm)
1
Crop/
Commodity
MRID#
Total
Appl.
Rate
(
lb
ai/
A)
End­
use
Product
PHI
(
days)
n
Min.
Max.
HAFT2
Median
3
(
STMdR)
Mean
3
(
STMR)
Std.
Dev.
&
45778901
(
1x)
EC
Mint
(
0.225
lb
ai/
A
total
application
rate,
30­
day
PHI)

Mint,
hay
44416501
0.224­
0.227
(
1x)
3.6
lb/
gal
EC
29­
30
10
0.06
2.7
2.3
1.1
1.15
0.73
Onions
(
0.45
lb
ai/
A
total
application
rate,
PHIs
0
day
for
green
onion
and
14
days
for
dry
bulb)
Green
whole
plant
0
28
0.57
7.5
5.2
2.1
2.4
0.27
Dry
bulb
43786401
0.44
(
1x)
3.6
lb/
gal
EC
14
28
<
0.05
0.18
0.13
0.03
0.05
0.02
Rice
5
(
0.34
lb
ai/
A
total
application
rate,
35­
day
PHI)
Straw
32
0.69
17.0
16.5
2.30
4.11
4.62
Grain
0.28
(
1x)
3.6
lb/
gal
EC
34­
49
32
0.03
5.20
5.05
0.89
1.49
1.55
Straw
8
0.77
9.50
8.00
2.40
3.46
3.10
Grain
45080811
0.31
(
1x)
1.04
lb/
gal
EC
35­
40
8
0.06
2.50
2.00
0.61
1.01
1.00
Sorghum
(
0.45
lb
ai/
A
total
application
rate,
PHIs
are
30
days
for
forage
and
21
days
for
grain
and
stover)
0
14
1.8
11.6
10.7
5.4
6.29
2.54
29­
31
24
1.5
8.2
8.1
3.8
4.40
1.92
Forage
0.22
(
0.5x)
37­
38
6
4
3.8
8.3
7.4
6.5
6.28
1.86
18­
22
24
2.8
11.7
9.2
5.5
5.81
2.25
Stover
28
6
4
4.3
14.2
13.5
8.6
8.90
5.29
18­
22
24
0.52
2.3
2.1
0.98
1.14
0.51
Grain
45275801
0.44
(
1x)
3.6
lb/
gal
EC
28
6
4
1.8
2.4
2.1
2.0
2.05
0.26
Soybean
(
0.34
lb
ai/
A
total
application
rate,
30­
day
PHI)
Forage
28
0.33
5.40
5.20
1.85
2.42
1.64
Hay
21­
32
28
0.48
21.0
21.0
2.90
4.78
5.29
Seed
26
0.06
0.80
0.47
0.19
0.22
0.15
Fodder
43386502
0.33
(
1x)
3.6
lb/
gal
EC
41­
99
28
<
0.05
6.20
5.40
0.58
1.15
1.48
0.32­
0.35
7
8
0.56
1.40
1.40
0.72
0.86
0.34
0.23­
0.25
7
8
0.10
0.67
0.63
0.16
0.27
0.23
Seed
46473001
0.34­
0.36
7
3.6
lb/
gal
EC
30
8
0.17
0.94
0.90
0.23
0.39
0.32
Seed
0.24­
0.26
19­
24
40
<
0.10
0.268
0.215
0.05
0.09
0.052
Forage
0.24­
0.25
0
40
1.70
12.0
8.43
4.37
4.90
2.32
Hay
46576301
0.24­
0.25
1.04
lb/
gal
EC
0
40
2.63
8.43
26.4
12.1
12.74
5.66
Strawberry
(
0.45
lb
ai/
A
total
application
rate,
0­
day
PHI)

Strawberry
45542401
044
(
1x)
3.6
lb/
gal
EC
0
16
0.07
0.69
0.60
0.32
0.35
0.19
Sugar
Beet
(
0.34
lb
ai/
A
total
application
rate,
21­
day
PHI)
0
22
<
0.05
0.61
0.565
0.025
0.086
0.160
Roots
0.33
(
1x)
21­
23
22
<
0.05
0.08
0.065
0.025
0.035
0.018
0
22
0.89
5.20
5.05
2.25
2.52
1.17
Tops
44757207
0.33
(
1x)
45%
WP
21­
23
22
0.41
2.90
2.85
0.75
1.10
0.80
0
8
<
0.05
0.42
0.30
0.11
0.14
0.12
Roots
21
8
<
0.05
0.23
0.17
0.11
0.13
0.06
0
8
2.10
6.10
5.20
3.75
4.05
1.26
Tops
0.33
(
1x)
45%
WP
21
8
0.74
2.60
2.60
1.50
1.67
0.67
0
8
<
0.05
0.34
0.28
0.11
0.15
0.10
Roots
21
8
0.05
0.23
0.18
0.17
0.14
0.06
0
8
2.60
8.00
5.65
3.70
4.44
1.86
Tops
45080807
0.33
(
1x)
1.04
lb/
gal
EC
21
8
0.77
9.20
7.90
2.85
3.67
2.84
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
23
of
63
Table
7.
Summary
of
Residue
Data
from
Crop
Field
Trials
with
Propiconazole
(
EC
and/
or
WP).
Combined
Residues
(
ppm)
1
Crop/
Commodity
MRID#
Total
Appl.
Rate
(
lb
ai/
A)
End­
use
Product
PHI
(
days)
n
Min.
Max.
HAFT2
Median
3
(
STMdR)
Mean
3
(
STMR)
Std.
Dev.

Wheat
(
0.22
lb
ai/
A
total
application
rate,
PHIs
are
30,
45
and
35
days
of
forage,
hay
and
grain)
Total
Combined
Residues
0
24
1.20
10.70
8.70
3.75
4.37
2.29
Forage
30­
32
24
0.09
1.70
1.50
0.60
0.70
0.48
Straw
24
<
0.05
4.20
3.85
0.84
0.98
1.04
Grain
44411206
0.22
(
1x)
3.6
lb/
gal
EC
54­
91
24
<
0.05
0.08
0.06
0.03
0.03
0.02
Forage
29­
32
42
<
0.05
1.91
1.58
0.20
0.33
0.35
Hay
0.11
(
0.5x)
43­
50
42
<
0.05
1.10
1.04
0.23
0.30
0.25
Straw
42
0.41
6.21
5.32
1.59
2.02
1.25
Grain
0.11­
0.12
(
0.5x)
27­
57
42
<
0.05
0.13
0.09
0.03
0.04
0.03
Straw
42
0.20
8.27
7.49
2.71
3.31
2.17
Grain
44757208
0.22­
0.23
(
1x)
3.6
lb/
gal
EC
27­
57
42
<
0.05
0.20
0.18
0.05
0.07
0.06
Parent
Residues
8
Forage
29­
32
42
<
0.05
0.49
0.36
0.025
0.06
0.08
Hay
0.11
(
0.5x)
43­
50
42
<
0.05
0.20
0.16
0.025
0.04
0.03
Straw
42
<
0.05
1.63
1.62
0.19
0.45
0.51
Grain
0.11­
0.12
(
0.5x)
27­
57
42
<
0.05
0.03
<
0.05
0.025
0.025
0.00
Straw
42
<
0.05
3.49
3.21
0.25
0.73
0.91
Grain
44757208
0.22­
0.23
(
1x)
3.6
lb/
gal
EC
27­
57
42
<
0.05
0.05
<
0.05
0.025
0.025
0.00
1
Unless
otherwise
indicated,
total
propiconazole
residues
were
determined
as
2,4­
DCBA
and
are
expressed
in
parent
equivalents.
The
method
LOQ
for
propiconazole
residues
is
0.05
ppm.
Residues
are
not
corrected
for
procedural
recoveries.
For
calculation
of
the
median,
mean,
and
standard
deviation,
½
LOQ
(
0.025
ppm)
was
used
for
samples
with
residues
<
LOQ.
2
HAFT
=
Highest
Average
Field
Trial.
3
STMdR
=
Supervised
Trial
Median
Residue;
STMR
=
Supervised
Trial
Mean
Residue.
4
The
field
trial
application
rate
relative
to
the
maximum
proposed
use
rate
is
listed
in
parentheses.
5
The
rice
field
trial
data
reflect
the
use
of
propiconazole
(
EC)
on
rice
as
either
a
single
application
during
heading
at
up
to
0.28
lb
ai/
A
or
a
split
application
during
heading
totaling
0.31
lb
ai/
A.
Side­
by­
side
tests
of
the
two
treatments
showed
no
differences
in
residue
in/
on
grain
and
straw
between
the
two
treatments.
6
For
the
sorghum
field
trials,
residue
values
from
sampling
intervals
later
than
the
proposed
PHI
will
be
included
in
the
database
used
for
calculating
tolerances,
as
residue
levels
at
these
later
intervals
were
equivalent
or
higher
than
residues
observed
around
the
proposed
PHIs.
7
The
three
application
regimes
on
soybean
were,
from
top
to
bottom:
3
applications
at
0.11
lb
ai/
A
(
totaling
1x
rate),
2
applications
at
0.11
lb
ai/
A
(
totaling
0.67x
rate),
and
2
applications
at
0.17
lb
ai/
A
(
totaling
1x
rate).
Data
from
the
bottom
row
were
used
in
determining
tolerance
sine
it
represent
the
proposed
use
pattern.
8
Wheat
samples
were
also
analyzed
using
a
method
which
determined
only
residues
of
propiconazole.

Root
and
Tuber
Vegetables
Group
Carrot.
Field
trial
data
on
carrots
have
been
previously
reviewed
(
DP
Barcode
D219664,
L.
Kutney,
6/
14/
96).
In
a
total
of
10
field
trials
conducted
during
1994­
1995
in
CA,
FL,
MI,
NY,
OH,
TX
and
WA,
propiconazole
(
3.6
lb/
gal
EC)
was
applied
to
carrots
as
four
broadcast
foliar
applications
at
0.11
lb
ai/
A/
application
(
1x
rate,
7
tests)
or
0.22
lb
ai/
A/
application
(
2x
rate,
3
tests),
at
unspecified
RTIs,
for
totals
of
0.44
or
0.88
lb
ai/
A
(
1x
and
2x
seasonal
rates).
Applications
were
made
in
25
gal
of
water/
A,
and
included
the
use
of
a
spreader/
sticker
at
1%
v/
v.
A
single
control
and
single
(
2x
tests)
or
duplicate
(
1x
tests)
treated
samples
of
carrot
roots
were
collected
at
13­
14
DAT.
Samples
were
stored
frozen
from
collection
to
analysis
for
up
to
7
months,
an
interval
supported
by
the
available
storage
stability
data.
Total
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
in/
on
carrots
were
determined
using
GC/
ECD
Method
AG­
454B,
which
has
a
validated
method
LOQ
of
0.05
ppm.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
24
of
63
Following
four
broadcast
applications
of
propiconazole
(
EC)
totaling
0.44
lb
ai/
A
(
1x
rate),
residues
were
<
0.05­
0.17
ppm
in/
on
14
carrot
samples
harvested
13­
14
DAT,
with
three
samples
having
residues
<
LOQ.
Average
and
median
residues
were
0.01
ppm
in/
on
carrots
treated
at
1x.
In
the
three
tests
conducted
at
a
2x
rate
(
0.88
lb
ai/
A),
residues
were
0.10­
0.17
ppm
in/
on
3
samples
from
14
DAT,
and
averaged
0.13
ppm.

The
carrot
field
trial
data
are
adequate.
Although
only
seven
of
the
required
8
field
trials
were
conducted
at
the
1x
rate,
three
additional
field
trials
were
conducted
at
a
2x
rate
and
residues
in
these
tests
were
all
below
the
recommended
tolerance.

Sugar
beet.
In
one
set
of
11
field
trials
conducted
in
1997
(
44757207.
der1),
propiconazole
(
45%
WP)
was
applied
to
sugar
beets
as
three
broadcast
foliar
applications
during
tuber
development
at
0.11
lb
ai/
A/
application,
for
a
total
of
0.33
lb
ai/
A/
season.
Applications
were
made
at
retreatment
intervals
(
RTIs)
of
9­
12
days,
with
the
exception
of
one
site,
which
had
RTIs
of
6
and
14
days.
At
one
field
site
in
MN,
two
additional
plots
were
also
treated
similarly
with
three
applications
of
propiconazole
(
WP)
at
0.33
and
0.55
lb
ai/
A/
application
(
3x
and
5x
rates),
to
provide
samples
for
a
processing
study.
Single
control
and
duplicate
treated
samples
of
sugar
beet
roots
and
tops
were
harvested
from
each
site
at
0
and
21­
23
days
after
the
third
application
(
DAT).
At
two
sites,
duplicate
samples
of
roots
and
tops
were
collected
at
0,
7,
14,
21
and
28
DAT
to
examine
residue
decline.
Sugar
beet
root
and
top
samples
were
stored
frozen
for
up
to
9.9
months
prior
to
extraction
for
analysis.
Adequate
storage
stability
data
are
available
to
support
the
storage
intervals
and
conditions
for
the
current
field
trials.
Combined
residues
of
propiconazole
and
its
2,4­
dichlorobenzoic
acid
(
DCBA)
containing
metabolites
in/
on
sugar
beet
roots
and
tops
were
determined
using
an
adequate
GC/
ECD
method
(
Method
AG­
454B).
Concurrent
recoveries
were
conducted
and
the
%
recoveries
are
acceptable.
Total
propiconazole
residues
in/
on
sugar
beet
roots
were
<
0.05­
0.61
ppm
at
0
DAT
and
<
0.05­
0.12
ppm
at
21­
23
DAT,
and
total
residues
in/
on
tops
were
0.89­
5.2
ppm
at
0
DAT
and
0.41­
2.9
ppm
at
21­
23
DAT.
Average
residues
in/
on
roots
and
tops
were
respectively
0.09
and
2.52
ppm
at
0
DAT
and
0.04
and
1.10
ppm
at
21­
23
DAT.
The
highest
average
field
trial
(
HAFT)
residues
in/
on
roots
and
tops
were
respectively
0.57
and
5.1
ppm
at
0
DAT
and
0.08
and
2.9
ppm
at
21­
23
DAT.
In
the
two
residue
decline
tests,
residue
levels
in/
on
roots
were
low
and
remained
relatively
steady
from
0
to
28
DAT,
averaging
0.053
ppm
at
0
DAT,
0.064
ppm
at
14
DAT,
and
0.054
ppm
at
28
DAT.
However,
residues
in/
on
tops
declined
steadily
at
longer
post­
treatment
intervals,
averaging
2.68
ppm
at
0
DAT,
1.15
ppm
at
14
DAT
and
0.68
ppm
at
28
DAT.

The
number
of
trials
and
the
geographic
representations
are
adequate.
These
field
trial
data
will
support
the
use
of
propiconazole
(
WP)
on
sugar
beets
as
up
to
three
broadcast
foliar
applications
at
0.11
lb
ai/
A/
application,
at
a
minimum
RTI
of
10
days,
for
a
total
of
0.33
lb
ai/
A/
season,
with
either
a
0
or
21
day
pre­
harvest
interval.

In
another
set
of
sugar
beet
field
trials
conducted
in
1998
(
45080807.
der1),
propiconazole
was
applied
to
sugar
beets
in
4
side­
by­
side
tests
comparing
the
use
of
45%
WP
and
1.04
lb/
gal
EC
formulations.
In
each
test,
propiconazole
(
WP
or
EC)
was
applied
to
sugar
beets
as
three
broadcast
foliar
applications
during
tuber
development
at
0.11
lb
ai/
A/
application,
at
retreatment
intervals
of
10­
11
days,
for
a
total
of
0.33
lb
ai/
A/
season.
Single
control
and
duplicate
treated
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
25
of
63
samples
of
sugar
beet
roots
and
tops
were
harvested
from
each
site
at
0
and
21
DAT.
Samples
were
stored
frozen
from
collection
to
analysis
for
up
to
9.2
months,
an
interval
supported
by
available
storage
stability
data.
Combined
residues
of
propiconazole
and
its
2,4­
dichlorobenzoic
acid
(
DCBA)
containing
metabolites
in/
on
sugar
beet
roots
and
tops
were
determined
using
an
adequate
GC/
ECD
method
(
Method
AG­
626).
Following
three
applications
of
the
WP
formulation
totaling
0.33
lb
ai/
A,
total
propiconazole
residues
in/
on
sugar
beet
roots
ranged
from
<
0.05­
0.42
ppm
at
0
DAT
and
<
0.05­
0.23
ppm
at
21
DAT,
and
total
residues
in/
on
tops
ranged
from
2.10­
6.10
ppm
at
0
DAT
and
0.74­
2.60
ppm
at
21
DAT.
There
was
no
noticeable
decline
in
residues
in/
on
roots
between
0
to
21
DAT,
but
residues
did
decline
in/
on
tops
from
0
to
21
DAT.
Following
three
applications
of
the
EC
formulation
totaling
0.33
lb
ai/
A,
total
propiconazole
residues
in/
on
sugar
beet
roots
ranged
from
<
0.05­
0.34
ppm
at
0
DAT
and
0.05­
0.23
ppm
at
21
DAT,
and
total
residues
in/
on
tops
were
2.70­
8.0
ppm
at
DAT
and
0.77­
9.20
ppm
at
21
DAT.
Average
residues
in/
on
sugar
beet
roots
were
similar
for
both
formulations
at
both
0
and
21
DAT
(
0.13­
0.15
ppm),
and
average
residues
in/
on
sugar
beet
tops
were
similar
at
0
DAT
for
the
WP
(
4.05
ppm)
and
EC
(
4.44
ppm)
formulations.
However,
average
residues
in/
on
tops
at
21
DAT
were
considerably
higher
for
the
EC
formulation
(
3.67
ppm)
than
for
the
WP
formulation
(
1.67
ppm).
This
trend
toward
higher
residues
from
the
EC
formulation
at
21
DAT
was
evident
in
3
out
of
the
4
field
trials.

These
data
indicate
that
total
propiconazole
residues
from
the
WP
and
EC
formulations
are
similar
in/
on
sugar
beet
roots
harvested
at
0
or
21
DAT
and
in/
on
sugar
beet
tops
harvested
at
0
DAT.
However,
by
21
days
post­
treatment,
residues
in/
on
tops
were
substantially
higher
for
the
EC
formulation
than
for
the
WP
formulation.
Given
the
differences
between
the
two
types
of
formulations
in
residue
levels
on
sugar
beet
tops
at
21
DAT,
a
full
set
of
field
trials
are
required
on
tops
in
order
to
support
the
use
of
an
EC
formulation
on
sugar
beets.

Bulb
Vegetables
Group
Onion
(
green
and
dry
bulb).
Field
trial
data
on
green
and
dry
bulb
onions
have
been
previously
reviewed
(
DP
Barcode
D219664,
L.
Kutney,
6/
14/
96).
In
a
total
of
9
field
trials
conducted
during
1993
in
CA,
CO,
GA,
ID,
MI,
OR,
and
TX,
propiconazole
(
3.6
lb/
gal
EC)
was
applied
to
green
and
dry
bulb
onions
each
as
two
broadcast
foliar
applications
at
0.22
lb
ai/
A/
application
(
1x
rate,
7
tests)
or
0.44
lb
ai/
A/
application
(
2x
rate,
2
tests),
at
RTIs
of
7
days,
for
totals
of
0.44
or
0.88
lb
ai/
A
(
1x
and
2x
seasonal
rates).
Applications
included
the
use
of
a
surfactant
at
0.25%
v/
v.
A
single
control
and
single
(
2x
tests)
or
quadruplicate
(
1x
tests)
treated
samples
of
green
whole
plants
and
dry
bulb
onions
were
collected
at
14
DAT.

Samples
were
stored
frozen
from
collection
to
analysis
for
up
to
14
months,
an
interval
supported
by
the
available
storage
stability
data.
Total
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
in/
on
green
and
dry
bulb
onions
were
determined
using
GC/
ECD
Method
AG­
454B,
which
has
a
validated
method
LOQ
of
0.05
ppm.

Following
two
broadcast
applications
of
propiconazole
(
EC)
totaling
0.44
lb
ai/
A
(
1x
rate),
residues
were
0.57­
7.50
ppm
in/
on
28
samples
of
green
onions
harvested
at
0
DAT
and
average
residues
were
2.4
ppm.
In
the
two
2x
rate
tests,
residues
were
3.3
and
5.8
ppm
in/
on
the
two
samples
of
green
onions
at
0
DAT.
For
the
dry
bulb
onions
harvested
at
14
DAT,
residues
were
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
26
of
63
<
0.05­
0.18
ppm
in/
on
28
samples
from
the
1x
tests,
with
19
samples
having
residues
<
LOQ.
Average
residues
in/
on
dry
bulb
onions
were
0.05
ppm
from
the
1x
tests.
In
the
two
2x
rate
tests,
residues
were
<
0.05
and
0.41
ppm
in/
on
the
two
samples
of
dry
bulb
onions
at
14
DAT.
The
available
onion
data
will
support
the
proposed
use
pattern.

Leafy
Vegetables
(
except
Brassica
vegetables)
Group
Celery
(
leaf
petiole
vegetables,
subgroup
4B).
In
a
series
for
celery
field
trials
conducted
in
CA,
FL,
MI,
NY,
and
TX
(
PP#
8F3674,
C.
Deyrup,
12/
14/
88;
and
PP#
0F3869,
W.
Chin,
8/
15/
90),
a
3.6
lb/
gal
EC
formulation
of
propiconazole
was
applied
to
celery
during
crop
development
as
4
or
5
broadcast
foliar
applications
at
0.11
lb
ai/
A/
application,
at
RTIs
of
7­
14
days,
for
a
total
of
0.44­
0.55
lb
ai/
A/
crop
(
1x­
1.2x
rate).
In
four
tests,
propiconazole
(
EC)
was
also
applied
as
4
broadcast
applications
at
0.22
lb
ai/
A,
for
a
total
of
0.88
lb
ai/
A/
crop
(
2x
rate).
Applications
were
made
using
both
aerial
and
ground
equipment,
and
a
sticker
was
included
in
the
tank
mix
in
selected
trials.
Samples
of
celery
were
harvested
at
0,
7,
and
14
DAT
and
stored
frozen
for
up
to
12
months
prior
to
analysis.
Total
residues
of
propiconazole
and
its
2,4­
DCBA
metabolites
were
determined
using
GC/
ECD
Method
AG­
454,
which
has
an
LOQ
of
0.05
ppm.

Following
applications
totaling
0.44­
0.55
lb
ai/
A
(~
1x
rate),
total
propiconazole
residues
were
0.27­
4.98
ppm
in/
on
20
samples
of
celery
harvested
at
a
PHI
of
14
days.
Median
and
average
residues
were
0.60
and
1.13
ppm,
respectively,
with
a
standard
deviation
of
1.28
ppm.
Following
applications
totaling
0.88
lb
ai/
A
(
2x
rate),
residues
were
0.60­
2.52
ppm
in/
on
4
celery
samples
harvested
at
14
DAT.
Repeated
samplings
at
0,
7
and
14
indicated
that
residues
declined
at
longer
post­
treatment
intervals.

Additional
celery
field
trials
were
conducted
in
FL
during
1994
(
43655613.
der)
comparing
sideby
side
applications
of
propiconazole
formulated
as
a
45%
WP
and
a
3.6
lb/
gal
EC.
Each
formulation
was
applied
four
times
to
celery
as
broadcast
foliar
applications
during
crop
development
at
0.11
lb
ai/
A/
application,
at
retreatment
intervals
(
RTIs)
of
7
days,
for
a
total
of
0.44
lb
ai/
A/
season.
A
single
control
and
duplicate
treated
samples
of
whole
immature
plants
were
harvested
from
each
plot
at
0
days
after
the
final
application
(
DAT),
and
single
control
and
duplicate
treated
samples
of
mature
untrimmed
stalks
(
RAC)
were
harvested
from
each
plot
at
14
DAT.
Subsamples
of
trimmed
stalks
and
trimmings
were
also
collected
at
14
DAT.
Samples
were
stored
frozen
from
collection
to
analysis
for
up
to
9.5
months,
an
interval
supported
by
available
storage
stability
data.
Residues
of
propiconazole
and
its
2,4­
dichlorobenzoic
acid
(
DCBA)
containing
metabolites
in/
on
celery
were
determined
using
a
GC/
ECD
method
(
Method
AG­
454B).
Immediately
following
the
final
application
(
0
DAT),
residues
in/
on
whole
immature
plants
were
1.5­
2.1
ppm
for
the
EC
formulation
and
1.3­
1.5
ppm
for
the
WP
formulation.
At
maturity
(
14­
DAT),
residues
in/
on
untrimmed
stalks
were
0.27­
0.42
ppm
for
the
EC
formulation
and
0.43­
0.51
ppm
for
the
WP
formulation,
with
most
of
the
residues
being
associated
with
the
upper
leaves.
Residues
in/
on
trimmed
stalks
at
14
DAT
were
 
0.05
ppm
for
the
EC
and
0.05­
0.07
ppm
for
the
WP,
and
residues
in/
on
trimmings
were
0.41­
0.45
ppm
for
the
EC
and
0.49­
0.83
ppm
for
the
WP.
Average
residues
in/
on
untrimmed
stalks,
trimmed
stalks,
and
trimmings
were
0.35,
0.04,
and
0.43
ppm,
respectively,
for
the
EC
formulation,
and
0.47,
0.06,
and
0.66
ppm,
respectively,
for
the
WP
formulation.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
27
of
63
Although
the
data
are
limited,
residues
in/
on
celery
from
the
EC
and
WP
formulations
were
similar
in
this
trial.
Considering
both
the
original
celery
field
trials
and
the
side­
by­
side
tests,
adequate
celery
field
trial
data
are
available
to
support
the
proposed
use
on
of
propiconazole
(
EC
or
WP)
on
leaf
petiole
vegetables.

Legume
Vegetables
Group
Dried
Shelled
Beans
and
Peas,
except
soybean
(
subgroup
6C).
In
conjunction
with
an
earlier
petition
for
use
on
legume
vegetables,
limited
dry
bean
field
trial
data
were
submitted
and
reviewed
under
(
PP#
8F3674,
C.
Deyrup,
12/
14/
88).
In
a
single
field
trial
conducted
in
1984,
propiconazole
(
3.6
lb/
gal
EC)
was
applied
to
dry
beans
as
three
broadcast
foliar
applications
at
0.138
lb
ai/
A/
application,
for
a
total
of
0.41
lb
ai/
A/
season
(
1.2x
rate).
Duplicate
treated
samples
of
mature
beans
were
collected
at
25
DAT,
and
analyzed
for
combined
propiconazole
residues
using
GC/
ECD
Method
AG­
454,
which
has
an
LOQ
of
0.05
ppm.
Combined
residues
in/
on
beans
were
0.14
and
0.08
ppm
from
the
1.2x
rate.

Additional
dry
bean
field
trials
from
1989
were
later
submitted
and
reviewed
by
the
Agency
(
DP
Barcode
D210266
and
D210295,
M.
Rodriguez,
3/
5/
1997).
In
a
series
of
5
field
trials
conducted
in
ID,
CO,
ND,
NE
and
MI,
propiconazole
(
3.6
lb/
gal
EC)
was
applied
to
dry
bean
varieties
as
three
broadcast
foliar
applications
at
0.138
lb
ai/
A
(
5
tests)
or
0.276
lb
ai/
A
(
3
tests),
for
totals
of
0.41
or
0.83
lb
ai/
A/
season
(
1.2x
and
2.5x
rates).
Samples
of
vines
were
collected
from
each
trial
at
7
DAT,
and
samples
of
hay
and
mature
beans
were
collected
at
23­
31
DAT,
with
most
hay
and
bean
samples
being
collected
around
28
DAT.
Samples
were
stored
frozen
for
up
to
41
months
prior
to
analysis.
Combined
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
were
determined
using
GC/
ECD
Method
AG­
454B,
which
was
adequately
validated
in
conjunction
with
the
analysis
of
field
trial
samples.
The
validated
method
LOQ
is
0.05
ppm,
and
a
LOD
was
not
reported.
Following
three
applications
to
dry
beans
at
the
1.2x
rate,
combined
propiconazole
residues
were
1.20­
7.50
ppm
in/
on
10
samples
of
vines
at
7
DAT,
0.17­
4.90
ppm
in/
on
10
samples
of
hay
at
~
28
DAT,
and
<
0.05­
0.13
ppm
in/
on
10
samples
of
seeds
at
~
28
DAT.
Average
residues
were
3.11
ppm
for
vines,
2.11
ppm
for
hay,
and
0.08
ppm
for
seeds.
Maximum
residues
from
the
2.5x
rate
were
9.9,
15,
and
0.10
ppm
in/
on
vines,
hay
and
seeds,
respectively.

Insufficient
field
trial
data
are
available
to
support
the
purposed
use
of
propiconazole
on
dry
peas
and
beans
as
only
six
dry
bean
field
trials
are
available
and
no
dry
pea
field
trials
were
conducted.
For
a
subgroup
crop
tolerance
on
6C,
a
total
of
12
dry
bean
field
trials
and
5
dry
pea
field
trials
are
required.
In
addition,
the
available
dry
bean
field
trials
support
a
PHI
of
28
days
rather
than
the
14­
day
PHI
on
the
proposed
label.

Soybeans.
Limited
soybean
residue
data
were
originally
submitted
and
reviewed
under
PP#
8F3674
(
C.
Deyrup,
12/
14/
88),
to
support
a
use
on
legume
vegetables.
In
these
studies,
propiconazole
(
3.6
lb/
gal
EC)
was
applied
to
soybeans
in
3
field
trials
as
either:
three
applications
at
0.14
lb
ai/
A,
totaling
0.41
lb
ai/
A
(
1.2x
rate);
two
applications
at
0.16
lb
ai/
A,
totaling
0.33
lb
ai/
A
(
1x
rate);
or
three
applications
at
0.27
lb
ai/
A,
totaling
0.83
lb
ai/
A
(
3.7x
rate).
Applications
were
made
at
RTIs
of
3­
31
days.
Samples
of
hay
were
collected
at
77­
105
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
28
of
63
DAT,
and
samples
of
seeds
were
collected
at
64­
105
DAT.
All
samples
were
analyzed
for
combined
propiconazole
residues
using
GC/
ECD
Method
AG­
454,
which
has
an
LOQ
of
0.05
ppm.
Combined
residues
in/
on
seeds
were
0.15­
0.41
ppm
from
the
1.2x
rate,
0.10­
0.43
ppm
from
the
1x
rate,
and
0.61­
0.74
ppm
from
the
3.7x
rate,
and
combined
residues
in/
on
hay
were
0.77­
3.92
ppm
from
the
1.2x
rate
and
0.98­
2.05
ppm
from
the
1x
rate.
Given
the
longer
PHIs
for
hay
and
seed
in
these
studies,
these
residue
data
are
of
limited
value
in
assessing
the
currently
proposed
use
pattern,
which
has
much
shorter
PHIs.

More
complete
soybean
field
trial
data
were
later
submitted
by
Syngenta
and
reviewed
by
the
Agency
(
DP
Barcode
D210266
and
D210295,
M.
Rodriguez,
3/
5/
1997.
MRID
43386502).
In
a
series
of
14
field
trials
conducted
throughout
the
U.
S.,
propiconazole
(
3.6
lb/
gal
EC)
was
applied
to
soybeans
as
two
broadcast
foliar
applications
at
0.165
lb
ai/
A,
at
RTIs
of
~
21
days,
for
a
total
of
0.33
lb
ai/
A/
season
(
1x
rate).
The
first
application
was
made
at
the
beginning
at
pod
formation
(
Stage
R3)
and
the
second
application
was
made
at
pod
fill
(
Stage
R5).
Duplicate
treated
samples
of
forage
and
hay
were
collected
from
each
trial
at
21­
32
DAT,
with
most
samples
being
collected
around
30
DAT.
Duplicate
treated
samples
of
beans
and
fodder
were
collected
at
41­
99
DAT,
with
most
mature
samples
being
collected
around
~
50
DAT.
At
two
test
sites,
forage
and
hay
were
also
collected
at
0,
7,
14,
21
and
30
DAT,
to
examine
residue
decline.
Samples
were
stored
frozen
for
up
to
41
months
prior
to
analysis,
an
interval
that
is
supported
by
the
available
storage
stability
data.
Combined
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
in/
on
soybean
commodities
were
determined
using
GC/
ECD
Method
AG­
454B,
which
was
adequately
validated
in
conjunction
with
the
analysis
of
field
trial
samples.
The
validated
method
LOQ
is
0.05
ppm,
and
a
LOD
was
not
reported.
Following
two
applications
at
a
1x
rate,
combined
propiconazole
residues
were
0.33­
5.40
ppm
in/
on
forage
and
0.48­
21.0
ppm
in/
on
hay
harvested
at
~
30
DAT,
and
residues
averaged
2.42
ppm
for
forage
and
4.78
ppm
for
hay.
By
~
50
DAT,
combine
residues
were
0.06­
0.80
ppm
in/
on
mature
seeds
and
<
0.05­
6.20
ppm
in/
on
fodder,
and
residues
averaged
0.22
ppm
in/
on
seeds
and
1.15
ppm
in/
on
fodder.
[
Note:
fodder
residues
are
included
here
for
informational
purposes
only,
as
soybean
fodder
(
straw)
is
no
longer
a
regulated
commodity].
Data
from
both
residue
decline
trials
indicate
that
residues
in/
on
forage
and
hay
decrease
at
longer
post­
treatment
intervals.

A
total
of
20
soybean
field
trials
were
conducted
during
2003
in
EPA
Regions
2,
4,
and
5.
(
46576301.
der).
Each
field
trial
included
two
treated
plots,
one
for
the
harvest
of
forage
and
hay
and
the
other
for
the
harvest
of
seed.
In
the
forage
and
hay
plot,
a
multiple
active
ingredient
EC
formulation
containing
propiconazole
at
1.04
lb
ai/
gal
was
applied
as
three
broadcast
foliar
applications
beginning
at
early
to
mid­
flowering
(
BBCH
60­
65
or
R1­
R2)
at
0.075­
0.095
lb
ai/
A/
application,
at
retreatment
intervals
(
RTIs)
of
8­
11
days,
for
totals
of
0.24­
0.25
lb
ai/
A
(
0.75x).
All
applications
were
made
using
ground
equipment
and
included
the
use
of
a
non­
ionic
surfactant
at
0.125%
v/
v.
At
each
site,
soybean
forage
and
hay
were
harvested
at
0
days
after
the
last
application
(
DAT)
and
seeds
were
harvested
at
maturity,
19­
24
DAT.
At
two
field
sites,
forage
and
hay
samples
were
also
harvested
at
3,
~
5,
~
7,
and
10
DAT,
and
seeds
were
harvested
at
18,
21,
~
25,
~
30,
and
~
32
DAT
to
examine
residue
decline.
A
single
control
and
duplicate
treated
samples
of
each
commodity
were
collected
from
each
test
at
each
interval.
Samples
were
stored
frozen
from
collection
to
analysis
for
up
to
18
months,
an
interval
supported
by
available
storage
stability
data.
Combined
residues
of
propiconazole
and
its
2,4­
dichlorobenzoic
acid
(
DCBA)
containing
metabolites
in/
on
soybean
forage,
hay
and
seeds
were
determined
using
an
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
29
of
63
adequate
GC/
MSD
method,
which
is
a
modification
to
Method
AG­
626.
Although
recoveries
from
forage
and
hay
were
low,
averaging
65­
68%
at
all
fortification
levels,
the
recoveries
were
very
consistent
with
low
standard
deviations
( 
7%).
Recoveries
of
propiconazole
averaged
82%
(
±
6­
15%)
from
seed.
Therefore,
the
method
is
deemed
adequate
for
data
collection.
Combined
propiconazole
residues
ranged
from
1.70­
12.0
ppm
in/
on
forage
and
2.63­
27
ppm
in/
on
hay
at
0
DAT,
and
averaged
4.9
ppm
in/
on
forage
and
12.7
ppm
in/
on
hay.
For
mature
seeds
harvested
at
19­
24
DAT,
combined
residues
ranged
from
<
0.1­
0.27
ppm
and
averaged
0.09
ppm.
The
highest
average
field
trial
(
HAFT)
residues
were
8.43
ppm
for
forage,
26.4
ppm
for
hay,
and
0.21
ppm
for
seeds.
Data
from
the
two
residue
decline
trials
indicate
that
combined
residues
declined
slowly
in
forage
and
hay
from
0
to
10
DAT,
but
remained
relatively
steady
in
seeds
from
18
to
33
DAT.
Since
these
field
trials
were
conducted
at
0.75x
the
maximum
rate,
the
residue
data
were
not
used
in
the
tolerance
calculation.

To
support
a
proposed
later
application
timing
on
soybeans
(
up
to
Stage
R6),
Syngenta
also
recently
submitted
data
from
four
soybean
field
trials
conducted
in
IL,
IN
and
MS
during
2003
(
46473001.
der).
In
these
trials,
propiconazole
(
3.6
lb/
gal
EC)
was
applied
to
soybeans
as
lateseason
broadcast
foliar
applications
during
pod
and
seed
development.
Each
field
site
compared
three
different
application
regimes
for
propiconazole:
(
1)
three
applications
at
0.11­
0.12
lb
ai/
A
from
BBCH
Stages
71
to
89,
for
totals
of
0.32­
0.35
lb
ai/
A/
season
(
1x
rate);
(
2)
two
applications
at
0.10­
0.12
lb
ai/
A
at
BBCH
stages
77
to
89,
for
totals
of
0.23­
0.24
lb
ai/
A/
season
(
0.67x
rate);
and
(
3)
two
applications
at
0.17­
0.19
lb
ai/
A,
at
BBCH
stages
77
to
89
for
totals
of
0.33­
0.36
lb
ai/
A/
season
(
1x
rate).
The
BBCH
growth
stages
of
71­
89
are
equivalent
to
Stages
R4­
R8.
All
applications
were
made
using
ground
equipment
at
RTIs
of
13­
18
days,
and
did
not
include
the
use
of
any
adjuvants.
Single
control
and
duplicate
treated
samples
of
soybean
seed
were
harvested
from
each
test
at
30
DAT,
and
forage
and
hay
samples
were
not
collected.
Soybean
seed
samples
were
stored
frozen
for
up
to
8.5
months
prior
to
extraction
for
analysis.
Combined
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
in/
on
soybean
seeds
were
determined
using
GC/
ECD
Method
AG­
626,
which
was
adequately
validated
in
conjunction
with
the
analysis
of
field
trial
samples.
The
validated
method
LOQ
is
0.05
ppm,
and
a
LOD
was
not
reported.
Following
the
two
applications
totaling
0.33­
0.36
lb
ai/
A
(
1x
rate),
combined
residues
levels
in
soybean
seeds
were
0.17­
0.94
ppm
and
averaged
0.39
ppm
in/
on
8
samples
at
30
DAT.
No
residue
decline
trials
were
conducted.

Considering
all
the
available
soybean
field
trial
data,
HED
considers
sufficient
residue
data
are
available
to
support
tolerances
on
soybean
forage
and
hay
harvested
30
days
following
the
second
of
two
applications
totaling
0.33
lb
ai/
A
(
1x
rate).
Although
the
petitioner
has
requested
tolerances
for
soybean
forage
and
hay,
the
Agency
notes
that
the
currently
proposed
use
directions
for
soybean
prohibit
the
feeding
or
grazing
for
forage
or
hay.
HED
also
considers
sufficient
residue
data
are
available
to
support
tolerances
on
soybean
seed,
even
though
the
PHIs
of
the
soybean
seed
data
varies
from
30
to
90
days,
as
long
as
the
label
states
that
"
do
not
apply
later
than
the
R5
growth
stage'
or
`
apply
up
to
Stage
R6",
no
additional
field
trials
are
required
for
soybean
seeds.

Berries
Crop
Group
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
30
of
63
Bush
and
Cane
Berries.
Field
trial
data
on
blueberry,
blackberry,
and
raspberry
have
been
previously
reviewed
(
DP
Barcode
D219664,
L.
Kutney,
6/
14/
96).
In
a
total
of
9
field
trials
conducted
during
1994
in
ME,
MI,
NC,
NJ,
OR,
and
WA,
propiconazole
(
3.6
lb/
gal
EC)
was
applied
to
blueberries
or
cane
berries
as
five
foliar
applications
at
0.17
lb
ai/
A/
application
(
1x
rate,
6
tests)
or
0.34
lb
ai/
A/
application
(
2x
rate,
3
tests),
at
unspecified
RTIs,
for
totals
of
0.85
or
1.7
lb
ai/
A
(
1x
and
2x
seasonal
rates).
Applications
were
made
in
a
minimum
volume
of
20
gal/
A,
and
included
the
use
of
a
spreader/
sticker
at
1%
v/
v.
A
single
control
and
single
or
duplicate
treated
samples
of
berries
were
collected
at
30
DAT.
Samples
were
stored
frozen
from
collection
to
analysis
for
up
to
5
months,
and
combined
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
were
determined
using
GC/
ECD
Method
AG­
454B,
which
was
validated
in
conjunction
with
the
analysis
of
field
trial
samples.
The
validated
method
LOQ
is
0.05
ppm.

Following
applications
of
propiconazole
(
EC)
totaling
0.85
lb
ai/
A
(
1x
rate),
residues
were
0.14­
0.66
ppm
in/
on
12
berry
samples
harvested
at
30
DAT,
and
average
residues
were
0.36
ppm.
In
the
three
tests
conducted
at
a
2x
rate
(
1.7
lb
ai/
A),
residues
were
0.27­
0.98
ppm
in/
on
4
samples
from
30
DAT,
and
averaged
0.49
ppm.
These
field
trial
data
will
support
the
proposed
use
on
bush
and
cane
berries.

Cranberry.
The
available
cranberry
data
are
discussed
here
under
the
berry
crop
group,
although
cranberry
has
not
yet
been
officially
placed
in
the
expanded
berries
crop
group.
A
total
of
three
cranberry
field
trials
were
conducted,
including
two
in
WI
during
1995
and
one
in
OR
during
1999
(
45778901.
der
and
44338101.
der).
In
each
test,
propiconazole
(
3.6
lb/
gal
EC)
was
applied
to
established
fields
of
cranberries
as
four
broadcast
foliar
applications
at
0.156­
0.170
lb
ai/
A/
application,
for
a
total
of
0.66­
0.68
lb
ai/
A/
season.
The
first
two
applications
were
made
at
bud
break
and
at
~
14
days
after
bud
break,
and
the
final
two
applications
were
made
during
fruit
development.
Retreatment
intervals
(
RTIs)
were
13­
14
days
between
the
first
and
second
applications,
45­
56
days
between
the
second
and
third
applications,
and
11­
14
days
or
78
days
between
the
third
and
fourth
applications.
No
adjuvants
were
included
in
the
spray
mixes,
and
all
application
were
made
using
ground
equipment
in
18­
80
gal/
A.
One
to
four
control
samples
and
duplicate
treated
samples
of
cranberries
were
harvested
from
each
site
at
43
or
44
days
after
the
final
application
(
DAT).
Samples
were
stored
frozen
from
collection
to
analysis
for
up
to
78
days.
This
interval
is
supported
by
the
concurrent
storage
study
indicating
that
propiconazole
is
stable
at
­
20
º
C
in
cranberries
for
up
to
92
days.
The
combined
residues
of
propiconazole
and
its
2,4­
dichlorobenzoic
acid
(
DCBA)
containing
metabolites
in/
on
cranberries
were
determined
using
either
a
GC/
NPD
method
(
Method
AG­
454B,
modified)
for
the
1995
tests
or
a
GC/
ECD
method
(
Method
AAG­
626)
for
the
1999
test.
These
methods
are
updated
versions
of
the
current
tolerance
enforcement
method.
The
validated
method
limit
of
quantitation
(
LOQ)
is
0.05
ppm,
and
a
limit
of
detection
(
LOD)
was
not
reported.
Control
samples
of
cranberries
were
fortified
with
propiconazole
at
0.05,
0.50,
and
1.0
ppm
and
recoveries
at
each
level
averaged
74­
96%,
with
standard
deviations
range
from
2­
25
%.

Following
four
applications
of
propiconazole
(
EC)
totaling
0.66­
0.68
lb
ai/
A,
residues
were
0.18­
0.59
ppm
in/
on
6
cranberry
samples
harvested
43­
44
DAT,
and
averaged
0.32
ppm.
A
residue
decline
trial
was
not
conducted.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
31
of
63
These
field
trial
data
support
the
use
of
propiconazole
(
EC)
on
cranberries
with
up
to
four
applications
at
0.169
lb
ai/
A/
application,
for
a
total
of
0.68
lb
ai/
A/
season,
minimum
RTIs
of
14
days
and
a
PHI
of
45
days.
These
data
are
adequate
to
support
the
proposed
use
on
cranberries,
restricted
to
WI
and
the
Pacific
NW.

Strawberry.
Although
strawberry
has
not
yet
been
officially
placed
in
the
expanded
berries
crop
group,
the
available
strawberry
data
are
discussed
here
under
the
berry
crop
group.
In
8
field
trials
conducted
throughout
the
U.
S.
in
1996
(
45542401.
der),
propiconazole
(
3.6
lb/
gal)
was
applied
to
strawberries
as
four
broadcast
foliar
applications
during
fruit
development
at
0.11
lb
ai/
A/
application
at
retreatment
intervals
(
RTIs)
of
6­
8
days,
for
a
total
of
0.44
lb
ai/
A/
season.
All
applications
were
made
using
ground
equipment
at
volumes
of
50­
100
gal/
A,
and
no
adjuvants
were
used.
Single
control
and
duplicate
treated
samples
of
strawberries
were
harvested
from
each
site
on
the
same
day
as
the
final
application
(
0
DAT)
and
at
3
or
8
DAT
at
two
sites.
Samples
were
stored
frozen
from
collection
to
analysis
for
up
to
18
months,
an
interval
supported
by
available
storage
stability
data.
Combined
residues
of
propiconazole
and
its
2,4­
dichlorobenzoic
acid
(
DCBA)
containing
metabolites
in/
on
strawberries
were
determined
using
an
adequate
GC/
ECD
method
(
Method
AG­
45B).
The
validated
method
limit
of
quantitation
(
LOQ)
is
0.05
ppm,
and
the
limit
of
detection
(
LOD)
was
not
reported.
The
concurrent
recovery
of
propiconazole
averaged
77
±
8%
from
control
samples
fortified
at
0.05
or
0.50
ppm.
Although
the
raw
data
(
instead
of
corrected
data)
were
used
to
report
residue
values,
the
data
collection
method
detects
parent
plus
all
metabolites
containing
DCBA,
and
yet
the
Agency's
tolerance
expression
for
propiconazole
will
be
established
at
parent
only,
there
fore,
tolerances
will
not
under
represent
the
real
residue
levels.

Following
the
last
of
four
foliar
applications
totaling
0.44
lb
ai/
A,
total
uncorrected
propiconazole
residues
were
0.07­
0.69
ppm
in/
on
16
samples
of
strawberries
harvested
on
the
day
of
the
final
application
(
0
DAT).
Average
residues
were
0.35
ppm
and
the
highest
average
field
trial
(
HAFT)
residues
were
0.60
ppm.
Data
from
both
residue
decline
tests
indicated
that
residues
declined
on
strawberries
at
longer
post­
treatment
intervals.

The
number
of
trials
and
the
geographic
representation
of
the
trials
are
adequate.
These
data
will
support
the
use
of
propiconazole
(
EC)
on
strawberries
as
up
four
broadcast
foliar
applications
at
0.11
lb
ai/
A/
application,
at
a
minimum
RTI
of
7
days,
for
a
total
of
0.44
lb
ai/
A/
season,
with
a
0­
day
PHI.

Tree
Nuts
Crop
Group
Pecan.
Adequate
field
trial
data
on
pecans
were
submitted
in
conjunction
with
an
earlier
petition
for
use
of
propiconazole
on
pecans.
(
PP#
4F3007,
A.
Smith,
5/
15/
84).
In
eight
field
trials
conducted
in
AL,
OK,
GA,
LA,
TX,
and
NM,
propiconazole,
formulated
as
a
3.6
lb/
gal
EC,
was
applied
to
pecans
as
6­
10
foliar
applications
at
0.33
lb
ai/
A/
application,
beginning
a
bud
break
and
continuing
at
2­
week
intervals
until
shuck­
split.
All
tests
were
conducted
using
ground
equipment,
and
total
application
rates
were
2­
3.3
lb
ai/
A/
season
(
2­
3x
rate).
Residues
in/
on
all
samples
of
pecan
nutmeats
were
below
the
method
LOQs
(<
0.05
or
<
0.1
ppm).
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
32
of
63
Almond.
In
five
field
trials
conducted
during
1998
and
1999
in
CA,
propiconazole
was
applied
to
almonds
in
side­
by­
side
tests
comparing
the
use
of
45%
WP
and
3.6
lb/
gal
EC
formulations.
Applications
were
made
as
dilute
sprays
(
160­
207
gal/
A)
at
two
sites,
as
concentrated
sprays
(
10
gal/
A)
at
two
sites,
and
as
both
dilute
(
150
gal/
A)
and
concentrated
(
75
gal/
A)
sprays
at
the
fifth
site.
In
each
test,
propiconazole
(
EC
or
WP)
was
applied
four
times
to
almonds
as
foliar
applications
during
nut
development
at
0.22­
0.25
lb
ai/
A/
application,
at
retreatment
intervals
(
RTIs)
of
6­
14
days,
for
a
total
of
0.88­
0.91
lb
ai/
A/
season.
All
applications
were
made
using
ground
equipment
and
adjuvants
were
not
added
to
the
spray
mix.
Single
control
and
duplicate
treated
samples
of
nutmeats
and
hulls
were
collected
from
each
test
at
normal
maturity,
53­
63
days
after
the
final
application
(
DAT).
In
one
test,
duplicate
treated
samples
of
nutmeats
and
hulls
were
collected
at
40,
49,
55,
63,
and
68
DAT
to
examined
residue
decline.
Samples
were
stored
frozen
from
collection
to
analysis
for
up
to
10
months,
an
interval
supported
by
available
storage
stability
data.

Combined
residues
of
propiconazole
and
its
2,4­
dichlorobenzoic
acid
(
DCBA)
containing
metabolites
in/
on
almond
nutmeats
and
hulls
were
determined
using
adequate
GC/
ECD
methods
(
Methods
AG­
454B
and
AG­
626).
The
validated
method
LOQ
is
0.05
ppm
for
nutmeats
and
0.10
ppm
for
hulls,
and
a
LOD
was
not
reported.
Although
the
concurrent
recoveries
from
nutmeat
and
hulls
were
generally
low
(
60­
80%),
the
recoveries
were
relatively
consistent.
Therefore,
the
method
is
deemed
adequate
for
data
collection.
Although
the
raw
data
(
instead
of
corrected
data)
were
used
to
report
residue
values,
the
data
collection
method
detects
parent
plus
all
metabolites
containing
DCBA,
and
yet
the
Agency's
tolerance
expression
for
propiconazole
will
be
established
at
parent
only,
there
fore,
tolerances
will
not
under
represent
the
real
residue
levels.

Application
volume
and
formulation
type
had
no
apparent
effect
on
residue
levels.
For
samples
treated
with
the
WP,
combined
residues
range
from
<
0.05­
0.07
ppm
in/
on
12
samples
of
nutmeats
and
0.57­
4.60
ppm
in/
on
12
samples
of
hulls,
For
samples
treated
with
the
EC
formulation
,
combined
residues
range
from
<
0.05­
0.09
ppm
in/
on
12
samples
of
nutmeats
and
0.85­
4.20
ppm
in/
on
12
samples
of
hulls.
For
the
WP
and
EC
formulations,
average
residues
were
respectively
0.035
and
0.041
ppm
in/
on
nutmeats
and
1.78
and
2.06
ppm
in/
on
hulls.
When
data
from
both
formulations
are
pooled,
average
residues
are
0.038
ppm
in/
on
nutmeats
and
1.92
ppm
in/
on
hulls.

In
the
residue
decline
test,
residues
in/
on
nutmeats
declined
slightly
from
an
average
of
0.07
ppm
at
40
DAT
to
<
0.05
ppm
by
68
DAT.
However,
residue
levels
in/
on
hulls
were
variable
over
time.
Given
the
variability
of
residues
in/
on
hulls
at
a
single
sampling
interval
(
1.92
±
1.20
ppm;
53­
63
DAT),
the
decline
data
most
likely
represent
the
variability
in
hulls
residues
rather
than
any
trend
in
hull
residue
levels.

The
number
of
trials
and
the
geographic
representation
of
the
trials
are
adequate.
These
data
will
support
the
use
of
propiconazole
(
EC
or
WP)
on
almonds
as
up
four
foliar
applications
during
nut
development
at
0.22
lb
ai/
A/
application,
at
a
minimum
RTI
of
7
days,
for
a
total
of
0.88
lb
ai/
A/
season,
with
a
60­
day
PHI.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
33
of
63
Together
the
pecan
and
almond
field
trial
data
are
sufficient
to
support
the
proposed
uses
on
various
members
of
the
tree
nut
crop
group.

Cereal
Grains
and
Forage,
Fodder,
and
Straw
of
Cereal
Grains
Groups
Corn
(
field,
pop
and
sweet).
Propiconazole
(
EC
and
WP)
is
currently
registered
for
use
on
field,
pop,
and
sweet
corn
as
multiple
foliar
applications
through
silking
at
up
to
0.11
lb
ai/
A/
application,
at
minimum
RTIs
of
7
days,
for
a
total
of
0.44
lb
ai/
A/
season.
Labeled
PHIs
are
14
days
for
sweet
corn
ears
and
forage,
and
30
days
for
field
corn
forage.
No
PHI
is
specified
for
mature
field,
pop
or
seed
corn.

Residue
data
on
field
and
sweet
corn
supporting
the
original
use
pattern
were
reviewed
under
PP#
8F3674
(
C.
Deyrup,
12/
14/
88).
In
these
studies,
propiconazole
(
3.6
lb/
gal
EC)
was
applied
to
field
or
sweet
corn
in
14
tests
as
five
broadcast
foliar
applications
at
0.055­
0.11
lb
ai/
A,
for
a
total
of
0.39
lb
ai/
A/
season
(~
0.9x
rate),
and
in
3
tests
as
5­
8
foliar
applications
at
0.055­
0.11
lb
ai/
A,
for
a
total
of
0.44
lb
ai/
A/
season
(
1x
rate).
Seven
trials
were
also
conducted
using
exaggerate
applications
at
0.11­
0.22
lb
ai/
A,
for
totals
of
0.77­
0.88
lb
ai/
A/
season
(
1.8­
2x
rates).
In
the
sweet
corn
trials,
samples
of
ears
and
forage
were
harvested
from
all
tests
at
14­
38
DAT.
In
the
field
corn
trials,
forage
samples
were
collected
at
21­
43
DAT,
fodder
samples
were
collected
at
57­
78
DAT,
and
grain
samples
were
collected
at
21­
78
DAT.
All
samples
were
analyzed
for
combined
propiconazole
residues
using
GC/
ECD
Method
AG­
454,
which
has
an
LOQ
of
0.05
ppm.

In
the
sweet
corn
tests
conducted
at
0.9x
and
1.8x
rates,
combined
residues
were
<
0.05­
0.06
ppm
in/
on
K+
CWHR
and
1.27­
5.00
ppm
in/
on
forage;
maximum
forage
residues
were
found
at
14
DAT
from
a
0.9x
rate
test.
In
the
field
corn
tests
conducted
at
0.9­
1x
rates,
combined
residues
were
0.12­
9.30
ppm
in/
on
forage,
<
0.05
ppm
in/
on
grain,
0.16­
4.12
ppm
in/
on
fodder
(
stover).
In
the
field
corn
tests
conducted
at
1.8­
2x
rates,
combined
residues
were
1.36­
14.6
ppm
in/
on
forage,
<
0.05­
0.06
ppm
in/
on
grain,
0.67­
8.02
ppm
in/
on
fodder
(
stover).
Based
on
these
data,
temporary
tolerances
have
been
established
at
0.1
ppm
in/
on
corn,
field,
grain
and
corn,
sweet,
K+
CWHR,
and
at
12
ppm
in/
on
corn,
field,
forage
and
stover.
The
12
ppm
tolerance
for
field
corn
forage
was
set
at
12
ppm
because
the
maximum
residues
in
field
corn
forage
(
9.3
ppm)
were
observed
from
a
test
conducted
at
0.9x
rate;
therefore,
the
maximum
expected
residues
were
assumed
to
be
10.3
ppm.
These
tolerances
are
set
to
expire
on
11/
30/
08.

43655612.
der
In
addition
to
the
above
corn
data,
Syngenta
has
also
submitted
data
from
side­
by­
side
tests
conducted
during
1994
on
field
and
sweet
corn
(
43655612.
der),
comparing
residues
resulting
from
the
use
of
EC
and
WP
formulations.
Two
tests
each
were
conducted
on
field
and
sweet
corn.
In
each
test,
propiconazole
(
EC
or
WP)
was
applied
four
times
prior
to
silking
as
broadcast
foliar
applications
at
0.11
lb
ai/
A/
application,
at
RTIs
of
5­
9
days,
for
a
total
of
0.44
lb
ai/
A/
season
(
1x
rate).
In
the
field
corn
tests,
samples
of
forage
were
collected
at
30­
31
DAT
and
56­
63
DAT,
and
grain
and
stover
were
collected
at
93
or
118
DAT.
In
the
sweet
corn
tests,
samples
of
forage
were
collected
at
14
DAT,
and
samples
of
mature
forage
and
K+
CWHR
were
collected
at
25­
35
DAT.
All
samples
were
analyzed
for
combined
propiconazole
residues
using
GC/
ECD
Method
AG­
454B,
which
has
an
LOQ
of
0.05
ppm.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
34
of
63
In
the
side­
by­
side
tests,
combined
residues
in/
on
the
various
corn
commodities
were
similar
for
the
two
formulations.
For
field
corn
treated
with
the
EC,
residues
averaged
0.60
±
0.67
ppm
for
forage
at
~
30
DAT
and
0.98
±
1.11
ppm
for
mature
stover.
For
the
WP
formulation,
combined
residues
averaged
0.74
±
0.81
ppm
for
forage
at
~
30
DAT
and
1.20
±
1.34
ppm
for
mature
stover.
Combined
residues
were
<
LOQ
in/
on
all
samples
of
corn
grain,
regardless
of
the
formulation
used.
For
sweet
corn
treated
with
the
EC,
residues
averaged
0.23
±
0.15
ppm
for
forage
at
14
DAT
and
0.45
±
0.48
ppm
for
mature
forage.
For
the
WP
formulation,
residues
averaged
0.22
±
0.10
ppm
for
forage
at
14
DAT
and
0.43
±
0.43
ppm
for
mature
forage.
Combined
residues
were
<
LOQ
in/
on
all
samples
of
sweet
corn
ears
(
K+
CWHR)
for
both
formulations.

In
the
current
petition,
the
maximum
single
and
seasonal
use
rate
on
corn
are
unchanged,
but
Syngenta
is
now
proposing
to
allow
applications
to
field,
seed
and
pop
corn
later
in
the
season,
during
grain
development,
and
establishing
at
30­
day
PHI
for
grain
and
stover
of
field,
pop,
and
seed
corn.
Residue
data
reflecting
this
later
use
pattern
are
described
below;
no
new
residue
data
on
sweet
corn
have
been
submitted.

45080809
and
45080810.
der
In
a
total
of
28
field
trials
conducted
throughout
the
U.
S.
during
1998
and
1999,
propiconazole
(
1.04
lb/
gal
EC)
was
applied
to
field
corn
(
24
trials)
and
popcorn
(
4
trials).
With
a
few
exceptions,
each
field
corn
trial
included
one
treated
plot
for
the
collection
of
forage
and
another
plot
for
the
collection
of
grain
and
stover,
and
the
four
popcorn
field
trials
each
had
a
single
treated
plot
for
the
collection
of
only
grain
and
stover.
Propiconazole
(
EC)
was
applied
to
the
forage
plots
as
two
broadcast
foliar
applications
during
early
vegetative
development
at
a
rate
of
0.11
lb
ai/
A/
application,
for
a
total
of
0.22
lb
ai/
A.
The
retreatment
interval
(
RTI)
for
the
forage
applications
ranged
from
3­
8
days,
but
was
typically
7
days.
For
the
grain
and
stover
plots,
propiconazole
(
EC)
was
applied
to
the
corn
as
four
broadcast
foliar
applications
from
flowering
through
grain
development
at
rates
of
0.09­
0.14
lb
ai/
A/
application,
for
a
total
of
0.42­
0.47
lb
ai/
A.
The
RTIs
ranged
from
6­
9
days,
but
were
typically
7
days.
All
applications
were
made
using
ground
equipment
in
volumes
of
5­
25
gal/
A,
and
no
adjuvants
were
included
in
the
spray
mixtures.
At
two
of
the
field
corn
sites,
propiconazole
was
also
applied
as
four
broadcast
foliar
applications
during
grain
development
at
0.55
lb
ai/
A/
application,
for
a
total
of
2.2
lb
ai/
A
(
5x
rate).
In
four
of
the
1998
field
trials,
propiconazole
was
misapplied
to
the
forage
and/
or
stover
and
grain
plots
at
a
reduced
rate
(
0.05­
0.06
lb
ai/
A/
application);
these
field
trials
were
replaced
by
the
subsequent
1999
field
trials.

Single
control
and
duplicate
treated
samples
of
forage
were
harvested
at
29­
32
days
after
the
last
treatment
(
DAT),
except
in
three
tests
in
which
forage
was
collected
at
15,
51
or
67
DAT.
Single
control
and
duplicate
treated
samples
of
corn
stover
and
grain
were
harvested
at
28­
35
DAT
from
all
tests,
with
most
samples
being
collected
at
29­
30
DAT.
To
examine
residue
decline,
repeated
control
and
treated
samples
were
also
collected
at
two
sites
at
0,
9,
16,
23,
30
and
36/
37
DAT
for
forage
and
stover
and
at
9,
16,
23,
30
and
36
DAT
for
grain.
Samples
were
stored
frozen
from
collection
to
analysis
for
up
to
15.9
months,
an
interval
supported
by
available
storage
stability
data.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
35
of
63
Combined
residues
of
propiconazole
and
its
2,4­
dichlorobenzoic
acid
(
DCBA)
containing
metabolites
in/
on
corn
forage,
grain
and
stover
were
determined
using
adequate
GC/
ECD
methods
(
Methods
AG­
454B
and
AG­
626).
The
validated
method
limit
of
quantitation
(
LOQ)
is
0.05
ppm,
and
the
limit
of
detection
(
LOD)
was
not
reported.
Concurrent
recoveries
of
propiconazole
averaged
93
±
11%
from
forage,
89
±
13
%
from
stover
and
90
±
15%
from
grain.

Following
the
two
early­
season
broadcast
foliar
applications
totaling
0.22
lb
ai/
A,
combined
propiconazole
residues
range
from
<
0.05­
1.90
ppm
and
averaged
0.45
ppm
in/
on
36
samples
of
forage
harvested
at
29­
32
DAT.
Following
the
four
broadcast
foliar
applications
during
flowering
through
grain
development
at
rates
totaling
0.42­
0.47
lb
ai/
A,
combined
residues
range
from
0.92­
19.6
ppm
in/
on
48
samples
of
stover
and
<
0.05­
0.15
ppm
in/
on
48
samples
of
grain
harvested
at
28­
35
DAT.
Average
residues
were
6.87
in/
on
stover
and
0.037
ppm
in/
on
grain,
and
the
highest
average
field
trial
(
HAFT)
residues
were
15.9
ppm
in/
on
stover
and
0.10
ppm
in/
on
grain.
In
the
two
5x
rate
tests,
combined
residues
were
23.2­
77
ppm
in/
on
four
samples
of
stover
and
<
0.05­
0.062
ppm
in/
on
four
samples
of
grain
harvested
at
29­
30
DAT.
Data
from
the
two
residue
decline
trials
indicated
that
residues
in/
on
forage
and
stover
decreased
at
longer
posttreatment
intervals.
However,
residue
decline
could
not
be
determined
in
grain
as
residues
in
grain
were
<
LOQ
in
all
but
two
samples
from
the
declined
trials.

The
number
of
trials
and
geographic
representation
of
the
trials
are
adequate.
These
data
support
the
use
of
up
to
four
broadcast
foliar
applications
of
propiconazole
(
EC)
to
field
or
pop
corn
through
grain
development,
up
to
the
dent
stage
(
R5
stage),
at
0.11
lb
ai/
A/
application,
at
a
minimum
RTI
of
7
days,
for
a
total
of
0.44
lb
ai/
A/
season.
The
data
also
support
a
PHI
of
30
days
for
harvest
of
forage,
grain
and
stover.
However,
these
most
recent
data
will
only
support
the
use
of
two
early­
season
applications
prior
to
the
harvest
of
forage.
If
the
petitioner
intends
to
support
total
use
rates
of
0.22
lb
ai/
A
to
field
corn
prior
to
the
harvest
of
forage,
then
the
current
residue
data
on
forage
indicate
that
the
tolerance
for
field
corn
forage
could
be
reduced
from
12
ppm
to
4.5
ppm.

Rice.
The
Agency
recently
reviewed
(
DP
Barcode
D240856,
T.
Morton,
2/
23/
05)
residue
data
from
eight
rice
field
trials
conducted
in
1996
reflecting
the
use
of
propiconazole
(
3.6
lb/
gal
EC)
as
either
a
single
broadcast
foliar
application
during
internode
elongation
at
0.28
lb
ai/
A
(
4
tests)
or
as
a
split
application
at
0.17
lb
ai/
A/
application
during
internode
elongation
and
again
at
booting,
for
a
total
of
0.34
lb
ai/
A
(
4
tests).
Combined
propiconazole
residues
were
<
0.05­
0.28
ppm
in/
on
grain
and
0.50­
1.75
ppm
in/
on
straw
at
45
days
following
the
single
application
at
0.28
lb
ai/
A,
and
<
0.05­
0.07
ppm
in/
on
grain
and
0.33­
1.62
ppm
in/
on
straw
at
45
days
following
the
second
of
the
two
split
applications.

45080811.
der
For
the
current
petition,
Syngenta
is
now
proposing
that
the
single
or
split
applications
of
propiconazole
be
allowed
later
in
the
season,
at
up
to
heading.
To
support
this
use,
Syngenta
submitted
16
new
rice
field
trials
conducted
during
1998
in
the
major
rice
producing
areas
of
the
U.
S.
(
45080811.
der).
At
each
site,
propiconazole
(
3.6
lb/
gal
EC)
was
applied
to
rice
as
a
single
broadcast
foliar
application
at
0.28
lb
ai/
A
during
heading
(
1x
rate).
Four
of
the
trial
sites
also
included
another
treatment,
in
which
propiconazole
(
1.04
lb/
gal
EC)
was
applied
as
split
broadcast
foliar
applications
around
heading
at
0.154
lb
ai/
A/
application,
at
retreatment
intervals
(
RTIs)
of
14
days,
for
a
total
of
0.31
lb
ai/
A/
season.
Single
control
and
duplicate
treated
samples
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
36
of
63
of
rice
straw
and
grain
were
harvested
from
each
site
at
34­
49
days
after
treatment
(
DAT),
with
14
sites
having
harvest
intervals
of
34­
37
days.
To
examine
residue
decline,
additional
samples
were
collected
from
two
test
sites
at
14,
21,
27­
28,
34­
38,
and
42­
45
DAT.
Samples
were
stored
frozen
from
collection
to
analysis
for
up
to
11.2
months,
an
interval
supported
by
the
available
storage
stability
data.

Combined
residues
of
propiconazole
and
its
2,4­
dichlorobenzoic
acid
(
DCBA)
containing
metabolites
in/
on
rice
grain
and
straw
were
determined
using
an
adequate
GC/
ECD
method
(
Method
AG­
626).
Concurrent
recoveries
from
rice
straw
showed
averaged
91
±
13%
and
from
rice
grain
91
±
7%.
The
validated
method
LOQ
is
0.05
ppm,
and
an
LOD
was
not
reported.

Following
a
single
application
of
propiconazole
(
EC)
at
0.28
lb
ai/
A
(
1x
rate),
total
propiconazole
residues
ranged
from
0.97­
17.0
ppm
in/
on
32
samples
of
straw
and
0.03­
6.50
ppm
in/
on
32
samples
of
grain
harvested
at
34­
49
DAT.
Average
residues
were
4.50
ppm
for
straw
and
1.76
ppm
for
grain.
At
the
four
sites
where
the
single
application
at
0.28
lb
ai/
A
was
compared
to
the
split
application
totaling
0.31
lb
ai/
A,
residues
were
similar
between
the
two
treatments.
Average
residues
in/
on
grain
and
straw
were
1.34
and
4.27
ppm,
respectively,
following
the
single
application,
and
1.17
and
4.04
ppm,
respectively,
following
the
two
split
applications.

In
the
two
residue
decline
tests,
residues
in/
on
rice
grain
remained
relatively
steadily
over
time,
averaging
1.45
ppm
at
14
DAT
and
1.22
ppm
at
~
45
DAT.
Residues
in/
on
straw
showed
a
slight
increase
at
longer
post­
treatment
intervals,
but
the
trend
could
not
be
verified
due
to
the
variability
in
the
residue
data
on
straw.
Average
residues
in/
on
straw
were
3.05
ppm
at
14
DAT
and
4.45
ppm
by
~
45
DAT.
The
slight
increase
in
straw
residues
may
be
the
result
of
drying
down
of
the
foliage
as
the
crop
matures.
The
most
recent
rice
field
trials
adequate
support
the
proposed
35­
day
PHI
and
a
minimum
RTI
of
14
days
for
the
split
applications.

Sorghum.
Propiconazole
(
3.6
lb/
gal
EC)
was
applied
to
sorghum
in
12
field
trials
conducted
during
1998
(
45275801.
der).
The
number
of
trials
and
the
geographic
representation
of
the
trials
are
adequate.
At
each
field
site,
separate
plots
were
established
for
the
collection
of
forage
or
grain
and
stover.
For
the
forage
plots,
propiconazole
was
applied
as
two
broadcast
foliar
applications
beginning
around
flower
initiation
at
0.11
lb
ai/
A/
application,
at
a
retreatment
interval
(
RTI)
of
5
days,
for
a
total
of
0.22
lb
ai/
A/
season
(
0.5x
seasonal
rate).
In
the
grain/
stover
plots,
propiconazole
was
applied
as
four
broadcast
foliar
applications
at
0.11
lb
ai/
A/
application,
beginning
at
flowering
or
early
grain
development,
for
a
total
of
0.44
lb
ai/
A/
season.
Two
test
sites
also
included
separate
grain/
stover
plots
treated
at
exaggerated
rates
of
0.33
or
0.55
lb
ai/
A/
application,
for
a
total
of
1.32
or
2.20
lb
ai/
A/
season
(
reported
as
3x
and
5x
rates).
The
RTIs
for
the
grain/
stover
plots
ranged
from
3­
11
days,
but
were
4­
5
days
at
most
test
sites.
Single
control
and
duplicate
treated
samples
were
collected
from
each
plot,
with
forage
samples
being
harvested
at
0
and
29­
31
days
after
the
final
treatment
(
DAT)
and
grain
and
stover
samples
being
harvested
18­
22
DAT.
Repeated
samples
were
also
collected
at
two
sites
to
examine
residue
decline,
with
forage
being
sampled
at
0,
9,
16,
23,
30
and
37/
38
DAT,
and
grain
and
stover
being
sampled
at
0,
7,
14,
21
and
28
DAT.
Samples
were
stored
frozen
for
up
to
17.1
months
prior
to
extraction
for
analysis.
Adequate
storage
stability
data
are
available
to
support
the
storage
intervals
and
conditions
for
the
current
sorghum
field
trials.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
37
of
63
Combined
residues
of
propiconazole
and
its
2,4­
dichlorobenzoic
acid
(
DCBA)
containing
metabolites
in/
on
sorghum
forage,
stover
and
grain
were
determined
using
an
adequate
GC/
ECD
method
(
Method
AG­
626,
modified),
which
was
adequately
validated
in
conjunction
with
the
analysis
of
field
trial
samples.
The
validated
method
limit
of
quantitation
(
LOQ)
is
0.05
ppm,
and
the
limit
of
detection
(
LOD)
was
not
reported.

Following
two
applications
totaling
0.22
lb
ai/
A
(
0.5x
rate),,
combined
residues
in/
on
forage
were
1.80­
11.6
ppm
in/
on
14
samples
at
0
DAT
and
1.5­
8.2
ppm
in/
on
24
samples
at
29­
31
DAT,
and
average
residues
in/
on
forage
were
6.3
ppm
at
0
DAT
and
4.4
ppm
at
29­
31
DAT.
Following
four
applications
totaling
0.44
lb
ai/
A(
1x
rate),
residues
were
2.8­
11.7
in/
on
24
samples
of
stover
and
0.52­
2.30
ppm
in/
on
24
samples
of
grain
harvested
at
18­
22
DAT,
and
average
residues
were
5.8
ppm
in/
on
stover
and
1.14
ppm
in/
on
grain.
In
the
exaggerated
rate
test
at
1.32
lb
ai/
A
(
3x
rate),
residues
were
12.6
and
15.0
ppm
in/
on
stover
and
4.7
and
4.8
ppm
in/
on
grain
at
18
DAT.
In
the
two
exaggerated
rate
tests
at
2.20
lb
ai/
A
(
5x
rate),
residues
were
7.4­
30.6
ppm
in/
on
stover
and
2.1­
7.1
ppm
in/
on
grain
at
18­
20
DAT.

Data
from
the
two
residue
decline
field
trials
showed
a
slight
downward
trend
in
residue
levels
in
all
three
commodities
over
time,
but
the
decline
was
erratic
in
forage
and
stover
and
there
was
a
substantial
degree
of
variability
in
residue
levels
at
each
interval.
The
Agency
notes
that
the
combined
residues
in
forage,
stover
and
grain
in
one
of
the
decline
trials
were
actually
higher
than
the
maximum
residues
observed
around
the
earlier
PHI.
Maximum
residues
in
forage
were
8.2
ppm
at
29­
31
DAT
and
8.3
ppm
at
37­
38
DAT;
maximum
residues
in
stover
were
11.7
ppm
at
18­
22
DAT
and
14.2
ppm
at
28
DAT;
and
maximum
residues
in
grain
were
2.3
ppm
at
18­
22
DAT
and
2.4
ppm
at
28
DAT.
As
residue
levels
at
these
later
intervals
were
equivalent
or
higher
than
residues
observed
around
the
proposed
PHIs,
residue
values
from
these
sampling
intervals
will
be
included
in
the
data
base
used
for
calculating
sorghum
tolerances.

The
sorghum
field
trial
data
are
adequate
and
support
the
proposed
use
pattern,
provided
that
the
label
is
amended
to
specify
a
maximum
total
application
rate
of
0.22
lb
ai/
A
on
sorghum
harvested
for
forage.

Wheat.
Previously
reviewed
residue
data
and
use
directions
for
propiconazole
on
wheat
have
allowed
for
a
single
application
up
to
heading
(
Feekes
Growth
Stage
10.5)
at
0.11
lb
ai/
A.
In
the
current
petition,
Syngenta
is
now
proposing
increasing
the
use
rates
for
wheat
(
and
barley,
rye,
triticale,
and
oats)
to
include
up
to
two
applications
at
0.11
lb
ai/
A
up
to
heading,
with
a
minimum
RTI
of
14
days.
In
evaluating
the
proposed
use,
this
review
will
only
consider
the
wheat
field
trial
data
including
the
two
applications
use
pattern.

The
Agency
recently
reviewed
(
DP
Barcode
D240856,
T.
Morton,
2/
23/
05)
residue
data
from
12
wheat
field
trials
conducted
in
1992­
93
reflecting
the
use
of
propiconazole
(
3.6
lb/
gal
EC)
as
two
broadcast
foliar
applications
at
0.11
lb
ai/
A,
at
Feekes
Growth
5
and
8,
for
a
total
of
0.22
lb
ai/
A/
season
(
1x
rate).
Retreatment
intervals
were
6­
31
days
and
all
applications
were
made
using
ground
equipment.
Single
control
and
duplicate
treated
samples
of
wheat
forage
were
harvested
from
each
site
0
and
30­
32
DAT,
and
mature
wheat
grain
and
straw
were
harvested
at
54­
91
DAT.
Wheat
hay
was
not
sampled.
Samples
were
stored
frozen
from
collection
to
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
38
of
63
analysis
for
up
to
19
months,
an
interval
supported
by
available
storage
stability
data.
Combined
residues
were
determined
using
GC/
ECD
Method
AG­
454B,
which
was
adequately
validated
in
conjunction
with
the
analysis
for
field
trial
samples.
The
validated
LOQ
is
0.05
ppm,
and
the
LOD
was
not
reported
Following
two
applications
totaling
0.22
lb
ai/
A
(
1x
rate),
combined
residues
in/
on
wheat
forage
harvested
at
0
and
30­
32
DAT
were
<
1.2­
10.7
ppm
and
0.09­
1.7
ppm,
respectively.
Combined
residues
in/
on
wheat
grain
and
straw
harvested
at
54­
91
DAT
<
0.05­
0.08
ppm
and
<
0.05­
4.2
ppm,
respectively.
Average
combined
residues
were
4.37
ppm
in/
on
forage
at
0
DAT,
0.70
ppm
in/
on
forage
at
~
30
DAT
(
proposed
PHI),
0.98
ppm
in/
on
straw,
and
0.03
ppm
in/
on
grain.
These
field
trial
data
do
not
adequately
support
the
currently
proposed
use
on
wheat
as
only
12
of
the
required
20
field
trials
were
conducted,
no
hay
samples
were
collected,
the
applications
were
made
earlier
in
the
season
(
Feekes
5
and
8).
However,
the
forage
residue
data
from
the
30­
DAT
samples
do
reflect
two
applications
to
forage,
although
the
number
of
tests
is
insufficient
to
support
a
forage
tolerance.

More
recently,
Syngenta
has
submitted
additional
wheat
field
trials
more
in
line
with
the
requested
use
pattern
on
wheat
(
44757208.
der1).
In
a
total
of
21
field
trials
conducted
throughout
the
U.
S.
during
1997,
propiconazole
(
3.6
lb/
gal
EC)
was
applied
to
at
least
three
separate
plots
of
wheat
at
each
site.
In
two
plots
at
each
site,
propiconazole
was
applied
as
a
single
broadcast
foliar
application
at
0.11­
0.12
lb
ai/
A
(
0.5x
rate)
at
either
Feekes
Growth
Stage
5
or
FGS
10.5.
The
early­
season
application
at
FGS
5
was
used
for
the
collection
of
forage
and
hay,
and
the
late­
season
application
at
FGS
10.5
was
used
for
collection
of
grain
and
straw.
In
the
third
plot,
propiconazole
was
applied
as
two
late­
season,
broadcast
foliar
applications
at
booting
and
heading
(
Feekes
Growth
Stages
10
and
10.5),
at
0.11­
0.12
lb
ai/
A/
application,
for
a
total
of
0.22­
0.23
lb
ai/
A
(
1x
rate).
This
plot
was
used
for
the
collection
of
grain
and
straw
samples.
All
applications
were
made
using
ground
equipment
at
spray
volumes
of
11­
25
gal/
A,
and
no
adjuvants
were
included
in
the
tank
mixtures.
For
the
plots
that
received
two
applications,
the
RTI
was
13­
22
days,
with
most
tests
having
a
RTI
of
14
days.

Single
control
and
duplicate
treated
samples
of
forage
were
harvested
at
29­
32
DAT,
and
hay
samples
were
cut
at
43­
50
DAT,
with
most
hay
samples
being
cut
at
45
DAT.
Single
control
and
duplicate
treated
samples
of
mature
wheat
grain
and
straw
were
harvested
at
27­
50
DAT,
with
most
samples
being
collected
around
40
DAT.
To
examine
residue
decline,
repeated
control
and
treated
samples
were
collected
at
two
sites
from
0­
37
DAT
for
forage,
29­
59
DAT
for
hay,
and
21­
73
DAT
for
grain
and
straw.
Samples
were
stored
frozen
from
collection
to
analysis
for
up
to
16.3
months,
an
interval
supported
by
available
storage
stability
data.

Combined
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
were
determined
using
GC/
ECD
Method
AG­
454
B,
which
was
adequately
validated
in
conjunction
with
the
analysis
of
field
trial
samples.
The
validated
method
LOQ
is
0.05
ppm
for
each
wheat
commodity,
but
the
LOD
was
not
reported.
Samples
were
also
analyzed
for
residues
of
propiconazole,
per
se,
using
a
GC/
NPD
method
from
PAM
Vol.
I
(
Method
302
E4
+
DG5);
this
method
was
also
adequately
validated
in
conjunction
with
the
analysis
of
field
trial
samples.
The
method
LOQ
for
propiconazole
was
0.05
ppm,
and
a
LOD
was
not
reported.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
39
of
63
Following
an
application
at
Feekes
Growth
Stage
5
at
0.11
lb
ai/
A
(
0.5x),
total
combined
residues
were
<
0.05­
1.91
ppm
in/
on
forage
harvested
at
29­
32
DAT
and
<
0.05­
1.10
ppm
in/
on
hay
cut
at
43­
50
DAT,
and
average
combined
residues
were
0.33
and
0.30
ppm
in/
on
forage
and
hay,
respectively.
Residues
of
parent
propiconazole
were
<
0.05­
0.49
ppm
in/
on
forage
and
<
0.05­
0.20
ppm
in/
on
hay,
and
averaged
0.06
and
0.04
ppm,
respectively.

Following
a
single
application
during
heading
at
0.11­
0.12
lb
ai/
A
(
0.5x),
total
combined
residues
were
0.41­
6.21
ppm
in/
on
straw
and
<
0.05­
0.13
ppm
in/
on
grain
harvested
at
maturity,
27­
57
DAT,
and
combined
residues
averaged
2.02
and
0.04
ppm
in/
on
straw
and
grain,
respectively.
Residues
of
parent
propiconazole
were
<
0.05­
1.63
ppm
in/
on
straw
and
<
0.05
ppm
in/
on
grain,
and
averaged
0.45
and
0.025
ppm,
respectively.

Following
two
broadcast
applications
during
booting
and
heading
at
total
rates
of
0.22
lb
ai/
A
(
1x
rate),
total
combined
residues
were
0.20­
8.27
ppm
in/
on
straw
and
<
0.05­
0.20
ppm
in/
on
grain
harvested
at
27­
57
DAT.
Combined
residues
averaged
3.31
and
0.07
ppm
in/
on
straw
and
grain,
respectively.
Residues
of
parent
were
<
0.05­
3.49
ppm
in/
on
straw
and
 
0.05
ppm
in/
on
grain,
and
averaged
0.73
and
0.025
ppm,
respectively.

The
most
recent
wheat
data
will
support
the
proposed
late­
season
use
pattern
for
wheat
and
the
PHIs
of
30
days
for
forage,
45
days
for
hay,
and
40
days
for
grain
and
straw.
Although
these
data
support
the
use
of
applications
totaling
0.22
lb
ai/
A
prior
to
harvest
of
mature
grain,
the
data
will
only
support
the
use
of
applications
totaling
0.11
lb
ai/
A,
prior
to
the
harvest
of
either
forage
or
hay.
Limited
field
trial
data
are
available
(
12
tests)
reflecting
1x
applications
to
forage,
but
no
data
are
available
for
hay
reflecting
the
1x
rate.
Therefore,
the
label
should
be
amended
to
specify
that
only
a
total
of
0.11
lb
ai/
A
may
be
applied
prior
to
the
harvest
or
grazing
of
forage
and
hay.
If
the
petitioner
intends
to
support
the
use
of
two
applications
at
1x
prior
to
harvest
of
forage
and
hay,
then
an
additional
8
field
trials
are
required
on
forage
and
a
complete
set
of
20
field
trials
would
be
required
for
hay.

Miscellaneous
Commodities
Mint.
In
five
field
trials
conducted
during
1995
in
Regions
5
and
11
(
44416501.
der),
propiconazole
(
3.6
lb/
gal
EC)
was
applied
twice
to
established
fields
of
mint
as
broadcast
foliar
applications
at
0.111­
0.114
lb
ai/
A/
application
at
RTIs
of
13­
14
days,
for
a
total
of
0.224­
227
lb
ai/
A/
season
(
1x
rate).
The
initial
application
was
made
when
plants
were
4­
8
inches
in
height,
and
all
applications
were
made
using
ground
equipment.
Duplicate
control
and
treated
samples
of
fresh
mint
hay
were
harvested
from
each
site
at
29­
30
DAT.
Samples
were
stored
frozen
from
collection
to
analysis
for
up
to
62
days,
an
interval
supported
by
available
storage
stability
data.
Total
residues
of
propiconazole
and
its
DCBA
containing
metabolites
in/
on
mint
were
determined
using
a
GC/
ECD
Method
AG­
454B,
which
was
adequately
validated
in
conjunction
with
the
analysis
of
field
trial
samples.
The
validated
method
LOQ
is
0.05
ppm,
and
an
LOD
was
not
reported.

Following
applications
of
propiconazole
(
EC)
at
rates
totaling
0.224­
0.227
lb
ai/
A/
season
(
1x
rate),
total
propiconazole
residues
were
0.06­
2.7
ppm
and
averaged
1.15
ppm
in/
on
10
samples
of
mint
hay
harvested
at
29­
30
DAT.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
40
of
63
Conclusions
The
available
field
trial
data
on
almonds,
bush
and
cane
berries,
carrots,
celery,
cranberries,
mint,
onions,
pecans,
rice
and
strawberries
are
adequate
and
support
the
proposed
use
patterns
for
propiconazole
(
EC
or
WP)
on
these
crops.
The
number
and
geographic
distribution
of
the
field
trials
are
adequate,
and
the
appropriate
samples
were
collected
at
the
proposed
PHIs.
Based
on
available
side­
by­
side
studies
with
almonds,
celery,
field
corn,
and
sugar
beets
comparing
the
EC
and
WP
formulations,
the
general
results
are
that
the
residues
are
similar
with
the
two
formulations,
with
the
exception
of
sugar
beet
tops
where
the
EC
formulation
resulted
in
higher
residues.
For
crops
other
than
almonds,
celery,
field
corn,
and
sugar
beets,
data
were
generated
for
only
the
EC
formulation.
Sugar
beets
are
the
only
crop
for
which
most
of
the
data
reflect
the
WP
formulation.
HED
concluded
that
adequate
data
are
available
to
support
use
of
both
formulations
on
all
crops
in
these
petitions
with
the
exception
of
sugar
beets.

The
available
bush
and
cane
berries
field
trial
data
will
support
a
general
use
on
all
members
of
the
berry
crop
group
(
13);
the
celery
field
trial
data
will
support
uses
on
all
members
of
the
leafy
petioles
crop
subgroup
(
4B);
and
the
onion
(
green
and
dry
bulb)
field
trial
data
will
support
uses
on
all
members
of
the
bulb
vegetable
crop
group
(
3).
The
almond
and
pecan
data
will
support
uses
on
all
members
of
the
tree
nut
crop
group
(
14);
however,
use
directions
for
all
tree
nuts,
except
pecans,
should
be
amended
to
specify
a
minimum
PHI
of
60
days.

Adequate
field
trial
data
have
previously
been
reviewed
supporting
the
current
use
directions
on
sweet
corn.
The
available
field
and
pop
corn
field
trial
data
are
adequate
and
support
the
use
of
up
to
four
late­
season
broadcast
foliar
applications
of
propiconazole
(
EC)
to
field
or
pop
corn
through
grain
development,
up
to
the
dent
stage
(
R5
stage),
at
0.11
lb
ai/
A/
application,
for
a
total
of
0.44
lb
ai/
A/
season.
The
data
support
a
PHI
of
30
days
for
harvest
of
forage,
grain
and
stover.
However,
the
most
extensive
data
on
field
corn
forage
will
only
support
the
use
of
two
earlyseason
applications
prior
to
the
harvest
of
forage.
The
current
time­
limited
tolerance
of
12
ppm
on
field
corn
forage
can
be
reduced
to
4.5
ppm
if
the
petitioner
intends
to
only
support
total
use
rates
of
0.22
lb
ai/
A
to
field
corn
prior
to
the
harvest
of
forage.

The
sorghum
field
trial
data
are
also
adequate
and
support
the
proposed
use
pattern,
provided
that
the
label
is
amended
to
specify
a
maximum
total
application
rate
of
0.22
lb
ai/
A
on
sorghum
harvested
for
forage.

There
are
no
sufficient
field
trial
data
to
support
the
purposed
use
on
dry
peas
and
beans
as
only
six
dry
bean
field
trials
are
available
and
no
dry
pea
field
trials
were
conducted.
For
a
subgroup
crop
tolerance
on
6C,
a
total
of
12
dry
bean
field
trials
and
5
dry
pea
field
trials
are
required.
In
addition,
the
available
dry
bean
field
trials
support
a
PHI
of
28
days
rather
than
the
14­
day
PHI
on
the
proposed
label.
HED
recommends
against
the
establishment
of
permanent
tolerance
on
subgroup
crop
6C
until
additional
field
trial
data
are
submitted.

For
soybeans,
after
considering
all
the
available
soybean
field
trial
data,
HED
concluded
that
sufficient
residue
data
are
available
to
support
tolerances
on
soybean
forage
and
hay
harvested
30
days
following
the
second
of
two
applications
totaling
0.33
lb
ai/
A
(
1x
rate).
Although
the
petitioner
has
requested
tolerances
for
soybean
forage
and
hay,
the
Agency
notes
that
the
currently
proposed
use
directions
for
soybean
prohibit
the
feeding
or
grazing
for
forage
or
hay.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
41
of
63
HED
also
considers
sufficient
residue
data
are
available
to
support
tolerances
on
soybean
seed,
even
though
the
PHIs
of
the
soybean
seed
data
varies
from
30
to
90
days,
since
soybean
mature
at
different
times
depending
on
the
growth
regions,
PHI
can
vary
from
region
to
region,
therefore,
provided
the
label
has
such
language
as
"
do
not
apply
later
than
the
R5
growth
stage'
or
`
apply
up
to
Stage
R6",
no
additional
field
trials
are
required
for
soybean
seeds.

For
sugar
beets,
adequate
field
trial
data
are
available
to
support
the
use
of
the
45%
WP
formulation
at
the
proposed
rate.
However,
based
on
the
results
of
the
side­
by­
side
tests
with
the
WP
and
EC
formulations,
residues
in/
on
tops
at
the
proposed
21­
day
PHI
are
likely
to
be
higher
for
the
EC
formulation
than
the
WP
formulation.
Therefore,
a
complete
set
of
field
trial
data
is
required
for
sugar
beet
tops
reflecting
the
use
of
the
EC
formulation.

The
available
wheat
field
trial
data
for
grain
and
straw
are
adequate
and
will
support
the
proposed
late­
season
use
pattern
on
wheat,
barley,
rye
and
oats;
however,
the
available
residue
data
on
forage
and
hay
will
only
support
a
maximum
use
rate
of
0.11
lb
ai/
A
prior
to
the
harvest
of
forage
or
hay.
The
use
directions
must
be
amended
to
specify
a
maximum
total
application
rate
of
0.11
lb
ai/
A
on
wheat,
barley,
oats
or
rye
harvested
for
forage
or
hay.
If
the
petitioner
intends
to
support
the
use
of
two
applications
totaling
0.22
lb
ai/
A
prior
to
harvest
of
forage
and
hay,
then
an
additional
8
field
trials
are
required
on
forage
and
a
complete
set
of
20
field
trials
are
required
for
hay.

860.1520
Processed
Food
and
Feed
43640401.
der5
(
rotated
alfalfa)
45080810.
der
(
field
corn)
44548402.
der2
(
wheat)
45050811.
der2
(
rice)
44757207.
der2
(
sugar
beet)
45275801.
der2
(
sorghum)
44757208.
der2
(
wheat)
46576302.
der
(
soybean)

Alfalfa
(
rotational
crop).
In
a
field
trial
conducted
during
1989
in
NE,
propiconazole
(
3.6
lb/
gal
EC)
was
applied
to
a
primary
crop
of
wheat
as
a
single
broadcast
foliar
application
at
flag
leaf
emergence
(
Feekes
Growth
Stage
8)
at
0.11,
0.33,
or
0.55
lb
ai/
A
(
0.5x,
1.5x
and
2.5x
rates).
The
wheat
was
grown
to
maturity
and
harvested,
and
a
rotational
crop
alfalfa
was
planted
77
DAT.
Alfalfa
hay
was
harvested
the
following
spring
(
380
DAT)
and
processed
into
meal
and
pellets
using
simulated
commercial
practices.
Prior
to
analysis,
hay,
meal
and
pellets
were
stored
frozen
up
to
27
months,
an
interval
supported
by
the
available
storage
stability
data.

Total
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
were
determined
using
GC/
ECD
Method
AG­
454
B,
which
was
adequately
validated
in
conjunction
with
the
analysis
of
field
trial
samples.
The
validated
method
LOQ
is
0.05
ppm,
and
an
LOD
was
not
reported.

Following
an
application
of
propiconazole
(
EC)
to
a
primary
wheat
crop
at
0.11
or
0.33
lb
ai/
A
(
0.5x
or
1.5x),
residues
were
<
0.05
ppm
in
hay,
meal
and
pellets
from
alfalfa
planted
at
a
77­
day
PBI.
For
the
application
at
0.55
lb
ai/
A
(
2.5x),
residues
were
<
0.05
ppm
in
alfalfa
hay
and
meal
and
0.06
ppm
in
pellets,
indicating
the
potential
for
possible
concentration
of
residue
at
1.2x
in
pellets.
However,
given
the
low
levels
of
concentration,
a
separate
tolerance
is
not
required
for
alfalfa
meal.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
42
of
63
Corn.
In
two
field
trials
conducted
during
1998,
propiconazole
(
1.04
lb/
gal
EC)
was
applied
to
two
plots
of
field
corn
at
each
site
as
four
broadcast
foliar
applications
during
grain
development
at
0.11
or
0.55
lb
ai/
A/
application
at
RTIs
of
5­
9
days,
for
totals
of
0.44
or
2.20
lb
ai/
A/
season
(
1x
and
5x
rates).
All
applications
were
made
using
ground
equipment
in
volumes
of
21­
25
gal/
A,
and
no
adjuvants
were
included
in
the
spray
mixtures.
Single
control
and
treated
bulk
samples
of
corn
grain
were
harvested
from
each
test
at
normal
crop
maturity,
29
or
30
DAT.
The
grain
was
cleaned
to
generate
AGF
and
then
processed
using
simulated
wet­
and
dry­
milling
procedures
into
meal,
grits,
flour,
starch
and
refined
oil.
Prior
to
analysis,
the
grain
and
processed
fractions
were
stored
frozen
for
up
to
10
months,
an
interval
supported
by
the
available
stability
data.

Total
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
were
determined
using
GC/
ECD
Method
AG­
454
B,
which
was
adequately
validated
in
conjunction
with
the
analysis
of
field
trial
samples.
The
validated
method
LOQ
is
0.05
ppm,
and
an
LOD
was
not
reported.

Total
combined
propiconazole
residues
in/
on
bulk
samples
of
corn
grain
harvested
at
29
or
30
DAT
were
<
0.05
ppm
from
the
1x
rate
tests
and
0.062
and
0.081
ppm
for
the
5x
rate
tests.
Except
for
AGF,
residues
in
processed
fractions
were
<
0.05
ppm
in
samples
from
the
1x
rate
tests.
Residues
in
AGF
from
the
1x
rate
tests
were
0.159­
0.208
ppm
from
the
IL
test
and
0.173
ppm
from
the
IA
test,
indicating
the
potential
for
concentration
of
residues
in
corn
grain
AGF.
However,
due
to
residues
being
<
LOQ
in
the
RAC
at
1x,
reliable
processing
factors
for
AGF
from
the
1x
rate
tests
could
not
be
calculated.

For
the
5x
rate
tests,
residues
were
also
<
0.05
ppm
in
meal,
grits,
flour
and
starch
and
were
<
0.05­
0.097
ppm
in
refined
oil.
Processing
factors
for
corn
meal,
grits,
flour
and
starch
were
<
0.6x­<
0.8x
and
averaged
<
0.7x,
and
the
processing
factors
for
refined
oil
were
<
0.6x­
1.6x
and
averaged
1x.
Residues
in/
on
AGF
from
the
5x
tests
were
0.250­
0.266
ppm
in
the
IL
test
and
1.04
ppm
in
the
IA
test.
As
the
control
sample
of
AGF
from
the
IL
test
had
apparent
residues
(
0.233­
0.264
ppm)
of
similar
magnitude
to
the
treated
samples,
a
processing
factor
was
not
calculated
for
AGF
from
the
test
in
IL.
The
processing
factor
for
AGF
from
the
5x
test
in
IA
was
12.8x.
The
maximum
theoretical
processing
factor
for
corn
grain
is
25x
for
corn
oil.
As
the
processing
factors
for
meal,
flour,
grits,
starch
and
refined
oil
were
 
1x,
separate
tolerances
are
not
required
for
these
processed
commodities.
However,
a
tolerance
will
be
required
for
AGF.
Based
on
HAFT
residues
of
0.1
ppm
for
corn
grain
and
the
12.8x
processing
factor,
the
maximum
expected
in
corn
grain
AGF
would
be
1.28
ppm.

Mint.
Adequate
data
are
available
from
two
mint
processing
studies
(
DP
Barcode
D209468,
W.
Wassell,
4/
25/
95).
In
two
field
trials,
propiconazole
(
EC)
was
applied
to
mint
at
rates
up
to
0.34
lb
ai/
A
(
1.5x
labeled
rate).
Samples
of
fresh
mint
hay
were
cut
90
DAT,
air
dried,
and
distilled
to
yield
mint
oil.
Samples
of
mint
hay
and
oil
were
stored
for
up
to
224
days
prior
to
analysis
using
an
adequate
GC/
ECD
method
(
AG­
454B).
Total
propiconazole
residues
were
0.12
ppm
in
fresh
hay
from
both
field
trials
and
were
<
0.05
and
0.08
ppm
in
oil
from
the
two
sites,
for
an
average
processing
factor
of
0.5x
for
mint
oil.
Therefore,
a
separate
tolerance
for
mint
oil
is
not
required.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
43
of
63
Rice.
In
a
two
field
trials
conducted
during
1998
in
AR
and
LA,
propiconazole
(
3.6
lb/
gal
EC)
was
applied
to
rice
as
a
single
broadcast
foliar
application
at
heading
at
0.28
or
1.40
lb
ai/
A
(
0.8x
and
4.1x
rates)
at
each
site.
Rice
was
grown
and
harvested
at
commercial
maturity,
35
DAT.
Following
harvest,
whole
grain
was
processed
using
simulated
commercial
procedures
into
polished
rice,
hulls
and
bran.
Prior
to
analysis,
rice
and
processed
fractions
were
stored
frozen
up
to
11.1
months,
an
interval
supported
by
the
available
storage
stability
data.

Combined
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
in/
on
rice
grain,
hulls,
bran
and
polished
rice
were
determined
using
GC/
ECD
Method
AG­
626,
which
was
adequately
validated
in
conjunction
with
the
analysis
of
treated
samples.
The
validated
method
LOQ
is
0.05
ppm
for
each
commodity,
and
a
LOD
was
not
reported.

Following
application
of
propiconazole
to
rice
at
0.28
or
1.40
lb
ai/
A
(
0.8x
and
4.1x),
combined
propiconazole
residues
in/
on
rice
grain
at
35
DAT
were
0.82
and
0.86
ppm
in
the
two
0.8x
tests
and
2.4
and
3.7
ppm
in
the
two
4.1x
tests.
Combined
residues
were
reduced
in
polished
rice
by
0.06x­
0.19x,
and
concentrated
in
rice
hulls
by
3.0x­
4.1x
and
in
bran
by
1.7x­
3.9x.
For
all
four
tests,
the
average
processing
factors
were
0.12x
for
polished
rice,
3.8x
for
hulls,
and
2.9x
for
bran.
Based
on
HAFT
residues
of
5.05
ppm
for
rice
grain
and
these
average
processing
factors,
the
maximum
expected
residues
would
be
19.2
ppm
in
hulls
and
14.6
ppm
in
bran.
These
data
indicate
that
separate
tolerances
should
be
established
at
20
and
15
ppm
for
rice
hull
and
bran,
respectively.

Sorghum.
In
two
field
trials
conducted
in
KS
and
TX
in
1998,
propiconazole
(
3.6
lb/
gal
EC)
was
applied
to
two
plots
of
sorghum
at
each
site
as
four
broadcast
foliar
applications
during
grain
development
at
0.11
or
0.55
lb
ai/
A/
application,
for
totals
of
0.44
or
2.2
lb
ai/
A/
season
(
1x
and
5x
rates).
All
applications
were
made
using
ground
equipment
in
volumes
of
12­
13
gal/
A,
and
included
the
use
of
a
surfactant
at
0.1­
0.25%
of
the
spray
volume.
Single
control
and
treated
bulk
samples
of
grain
were
harvested
from
each
test
at
normal
crop
maturity,
18
or
20
DAT.
The
grain
was
cleaned
to
generate
AGF
and
then
processed
using
simulated
commercial
procedures
into
flour.
Prior
to
analysis,
the
grain
and
processed
fractions
were
stored
frozen
for
up
to
15
months,
an
interval
supported
by
the
available
stability
data.

Combined
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
were
determined
using
GC/
ECD
Method
AG­
626
(
modified),
which
was
adequately
validated
in
conjunction
with
the
analysis
of
treated
samples.
The
validated
method
LOQ
is
0.05
ppm
for
each
commodity,
and
a
LOD
was
not
reported.

Total
propiconazole
residues
in/
on
bulk
samples
of
sorghum
grain
harvested
at
18­
20
DAT
were
0.43
or
1.2
ppm
following
applications
at
the
1x
rate
and
2.2
and
6.9
ppm
following
applications
at
the
5x
rate.
For
the
1x
rate,
residues
in
AGF
were
3.39
and
6.5
ppm
and
residues
in
flour
were
0.06
and
0.48
ppm.
For
the
5x
rates,
residues
in
AGF
were
9.2
and
21.3
ppm
and
residues
in
flour
were
0.22
and
2.6
ppm.
The
processing
factors
for
AGF
were
3.1x­
7.9x
and
averaged
5.2x,
and
the
processing
factors
for
flour
were
0.1x­
0.4x
and
averaged
0.3x.
Based
on
the
average
processing
factors
and
HAFT
residues
of
2.1
ppm
for
sorghum
grain,
the
maximum
expected
residues
would
be
0.6
ppm
in
sorghum
flour
and
10.9
ppm
in
sorghum
AGF.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
44
of
63
Soybean.
A
processing
study
for
soybeans
was
reviewed
in
conjunction
with
the
original
petition
on
legume
vegetables
(
PP#
8F3674,
C.
Deyrup,
12/
14/
88,
and
DP
Barcode
D210266
and
D210295,
M.
Rodriquez,
3/
5/
97).
Samples
of
mature
soybeans
bearing
combined
residues
of
0.40
or
0.61
ppm
were
processed
in
hulls,
meal,
oil
and
soapstock
using
simulated
commercial
practices.
Combined
residues
were
0.026
and
0.31
ppm
in/
on
hulls,
0.40
and
0.75
ppm
in
meal,
<
0.05
ppm
in
refined
oil
and
0.18
and
0.19
ppm
in
soapstock.
Average
processing
factors
were
0.7x
for
hulls,
1.1x
for
meal,
<
0.1x
for
refined
oil,
and
0.4x
for
soapstock.

In
addition,
the
Agency
has
more
recently
reviewed
a
study
on
soybean
AGF
(
DP
Barcode
D246884,
T.
Morton,
3/
10/
05).
In
two
tests
conducted
in
1997,
mature
samples
of
soybeans
were
harvested
45
or
56
days
following
two
foliar
applications
of
propiconazole
(
3.6
lb/
gal
EC)
at
0.17
lb
ai/
A/
application,
with
a
14
day
RTI,
for
a
total
of
0.33
lb
ai/
A
(
1x
rate).
Bulks
samples
of
seed
from
both
tests
were
cleaned
to
generate
AGF
samples,
and
seeds
and
AGF
samples
were
analyzed
for
combined
propiconazole
residues
using
GC/
ECD
Method
AG­
626,
which
has
an
LOQ
of
0.05
ppm.
Combined
residues
in/
on
seeds
averaged
0.28
and
0.20
ppm
from
the
two
tests,
and
combined
residues
in/
on
AGF
averaged
0.27
and
1.5
ppm
from
the
two
tests,
for
processing
factors
of
1x
and
7.5x,
respectively.
The
average
processing
factor
for
soybean
AGF
was
4.3x.

In
addition
to
the
above
soybean
processing
data,
a
soybean
processing
study
is
also
available
reflecting
foliar
applications
later
in
the
growing
season
of
a
MAI
EC
formulation
containing
propiconazole
at
1.04
lb
ai/
gal.
In
a
field
trial
conducted
during
2003
in
MS,
the
propiconazole
MAI
EC
formulation
was
applied
to
soybeans
as
three
broadcast
foliar
applications
during
pod
development
(
BBCH
75­
77)
at
0.398­
0.420
lb
ai/
A/
application,
at
RTIs
of
8­
9
days,
for
a
total
of
1.225
lb
ai/
A
(
3.6x
maximum
rate).
Single
bulk
samples
of
control
and
treated
seeds
were
harvested
at
commercial
maturity,
19
DAT.
Following
harvest,
samples
of
AGF
were
generated,
and
seeds
were
then
processed
using
simulated
commercial
procedures
into
hulls,
meal,
and
refined
oil.
Samples
of
seed
were
stored
frozen
for
up
to
3
months
prior
to
analysis,
and
samples
of
AGF
and
processed
commodities
were
stored
frozen
for
 
1
month;
these
intervals
are
supported
by
the
available
storage
stability
data.

Combined
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
were
determined
using
a
GC/
MSD
method,
which
is
a
modification
to
Method
AG­
626
that
uses
a
MSD
instead
of
ECD
for
detection
of
residues.
The
method
is
adequately
validated
in
conjunction
with
the
analysis
of
treated
samples.
The
validated
LOQ
was
0.5
ppm
for
all
matrices,
and
the
calculated
LODs
were
0.07
ppm
for
seeds,
0.4
ppm
for
hulls,
0.15
ppm
for
meal
and
0.14
ppm
for
refined
oil.
An
LOD
for
AGF
was
not
reported.

Following
three
applications
of
propiconazole
(
EC)
to
soybeans
during
pod
development
at
rates
totaling
1.23
lb
ai/
A
(
3.6x
rate),
combined
residues
were
1.23­
1.32
ppm
in/
on
seeds
(
RAC)
harvested
at
19
DAT
and
were
<
0.5
ppm
in/
on
hulls,
meal
and
refined
oil
and
39.4­
40.1
ppm
in/
on
AGF.
Based
on
the
average
combined
residues
in
seeds
(
RAC)
and
each
processed
fraction,
the
calculated
processing
factors
are
0.2x
for
hulls,
meal,
and
for
refined
oil,
and
32x
for
AGF.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
45
of
63
Both
soybean
processing
studies
indicate
that
combined
propiconazole
residues
are
unlikely
to
concentrate
in
hulls,
meal
and
refined
oil;
therefore,
separate
tolerances
are
not
required
for
these
commodities.
However,
both
studies
also
indicate
that
residues
are
likely
to
concentrate
in
soybean
AGF.
The
difference
between
the
two
processing
factors
for
AGF,
4.3x
and
32x,
was
considerable,
and
most
likely
reflects
the
different
application
timings
and
harvest
intervals
for
beans
in
the
two
studies.
In
the
study
with
the
lower
processing
factor
(
4.3x),
beans
were
harvested
at
45­
56
DAT,
and
in
the
study
with
the
higher
concentration
factor
(
32x),
beans
were
harvested
at
19
DAT.
As
the
petitioner
is
now
proposing
a
shorter
PHI
for
the
harvest
of
soybeans
(
30
days),
the
processing
factor
from
the
later
study
will
be
more
appropriate
for
estimating
soybean
AGF
residues.
Based
on
HAFT
residues
of
0.90
ppm
for
soybean
seed
and
the
32x
processing
factor,
the
maximum
expected
residues
would
be
30
ppm
in
soybean
AGF.

Sugar
beet.
In
a
field
trial
conducted
in
MN
in
1997,
propiconazole
(
45%
WP)
was
applied
to
sugar
beets
as
three
broadcast
foliar
applications
during
root
enlargement
at
either
0.11,
0.33
or
0.55
lb
ai/
A/
application,
at
a
RTI
of
10
days,
for
totals
of
0.33,
0.99
and
1.65
lb
ai/
A/
season
(
1x,
3x
and
5x
rates).
Sugar
beets
were
grown
and
harvested
at
commercial
maturity,
23
DAT.
Following
harvest,
sugar
beet
roots
from
each
rate
were
processed
into
refined
sugar,
dried
pulp
and
molasses
using
simulated
commercial
procedures.
Prior
to
analysis,
samples
were
stored
up
to
9.9
months,
an
interval
supported
by
available
storage
stability
data.

Combined
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
were
determined
using
GC/
ECD
Method
AG­
454B,
which
was
adequately
validated
in
conjunction
with
the
analysis
of
treated
samples.
The
validated
method
LOQ
is
0.05
ppm
for
each
commodity,
and
the
LOD
was
0.02
ppm.

Total
residues
were
0.03,
0.045
and
0.11
ppm
in/
on
roots
treated
at
the
1x,
3x
and
5x
rates,
respectively.
Residues
in
roots
were
above
the
LOQ
only
in
the
5x
treatment.
For
processed
fractions
from
1x,
3x,
and
5x
treatments,
residues
were
respectively
0.11,
0.26
and
0.54
ppm
in
molasses
and
0.18,
0.76,
and
0.81
ppm
in
dried
pulp.
Residues
in
refined
sugar
were
nondetectable
(<
0.02
ppm)
in
all
samples.
Processing
factors
from
all
three
tests
were
<
0.2­<
0.7x
for
refined
sugar,
6.0­
16.9x
for
molasses,
and
3.7­
7.4x
for
dried
pulp.
With
the
exception
on
one
for
the
processing
factors
for
molasses
(
16.9x
from
3x
rate
test),
the
processing
factors
were
below
the
maximum
theoretical
concentration
factor
for
sugar
beets,
which
is
12.5x.
Because
residues
were
above
the
LOQ
in
roots
from
only
5x
treatment,
the
processing
factors
for
refined
sugar
(<
0.2x),
molasses
(
7.4x)
and
dried
pulp
(
4.9x)
from
the
5x
treatment
should
be
used
for
determining
residues
in
sugar
beet
processed
fractions.
Based
on
HAFT
residues
of
0.18
ppm
for
sugar
beet
roots
and
the
above
processing
factors,
the
maximum
expected
residues
would
be
<
0.05
ppm
in
refined
sugar,
1.33
ppm
in
molasses,
and
0.88
ppm
in
dried
pulp.
These
data
indicate
that
separate
tolerances
should
be
established
at
1.5
and
1.0
ppm
for
sugar
beet
molasses
and
dried
pulp,
respectively.

Wheat.
Numerous
wheat
processing
studies
are
available
reflecting
one
or
more
applications
of
propiconazole
(
EC)
to
wheat
at
various
growth
stages.
The
Agency
previously
reviewed
(
DP
Barcode
D240856,
T.
Morton,
2/
23/
05)
a
series
of
wheat
processing
studies
conducted
in
1996
and
in
1992­
93.
In
the
four
tests
conducted
in
1996,
propiconazole
(
EC)
was
applied
to
wheat
as
a
single
broadcast
foliar
application
at
Feekes
Growth
Stage
8
(
flag
leaf
emergence)
at
0.55
lb
ai/
A
(
2.5x
rate).
Mature
grain
was
harvested
at
47­
68
DAT,
and
processed
into
AGF,
germ,
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
46
of
63
bran,
middlings,
shorts,
and
flour.
Total
combined
residues
were
determined
in
all
fractions
using
GC/
ECD
Method
AG­
454B,
which
has
a
LOQ
of
0.05
ppm
and
a
LOD
of
0.02
ppm.
Residues
in/
on
grain
from
the
four
tests
were
all
<
LOQ,
but
were
detectable
at
0.02­
0.04
ppm.
Processing
factors
were
all
 
1x
for
germ,
middlings
and
flour
samples,
and
were
<
1x­
1.3x
for
shorts,
1.5x­
3.0x
for
bran
and
2.0x­
24x
for
AGF.
Average
processing
factors
were
1.1x
for
shorts,
2.3x
for
bran,
and
9.6x
for
AGF.

In
the
other
four
tests
conducted
in
1992­
93,
propiconazole
(
EC)
was
applied
to
wheat
as
either
a
single
broadcast
foliar
application
at
Feekes
Growth
Stage
8
at
0.55
lb
ai/
A
(
2.5x
rate,
2
tests)
or
as
two
foliar
applications
at
0.55
lb
ai/
A
at
both
Feekes
Growth
Stages
5
and
8,
for
a
total
of
1.1
lb
ai/
A
(
5x
rate,
2
tests).
Mature
grain
was
harvested
at
54­
85
DAT,
and
processed
into
AGF,
germ,
bran,
middlings,
shorts,
and
flour.
Total
combined
residues
were
determined
in
all
fractions
using
GC/
ECD
Method
AG­
454B,
which
has
a
LOQ
of
0.05
ppm.
The
method
LOD
was
not
reported.
Residues
in/
on
grain
were
<
LOQ
in
the
two
tests
which
received
only
a
single
application
(
2.5x
rate)
and
were
0.08
and
0.43
ppm
in
the
two
tests
receiving
two
applications
(
5x
rate).
For
the
two
5x
test,
with
had
quantifiable
residues
in
grain,
processing
factors
were
all
<
1x
for
germ,
shorts,
middlings
and
flour,
and
were
0.9x
and
1.4x
for
bran
and
10x
and
12x
for
AGF.
Average
processing
factors
for
bran
and
AGF
were
1.2x
and
11x,
respectively.

In
addition
to
the
above
studies,
Syngenta
has
submitted
several
more
wheat
processing
studies
reflecting
the
use
of
propiconazole
at
later
growth
stages,
which
is
the
use
that
the
registrant
is
currently
proposing.
In
two
trials
conducted
in
1996
(
44548402.
der2),
propiconazole
(
EC)
was
applied
to
wheat
in
four
plots
at
each
site
as
a
single
broadcast
foliar
application
at
booting
(
Feekes
Growth
Stage
10)
or
at
heading
(
Feekes
Growth
Stage
10.5)
at
0.11­
0.12
lb
ai/
A
or
0.55­
0.62
lb
ai/
A
(
0.5x
and
2.5x
rates).
All
applications
were
made
using
ground
equipment
in
volumes
of
15­
21
gal/
A,
and
did
not
include
the
use
of
any
adjuvants.
Single
control
and
treated
bulk
samples
of
grain
were
harvested
from
each
test
at
normal
crop
maturity,
63­
67
days
following
the
application
at
booting
or
55­
57
days
following
the
application
at
heading.
The
grain
was
cleaned
to
generate
AGF
and
then
processed
using
simulated
commercial
procedures
into
wheat
germ,
bran,
middlings,
shorts
and
flour
(
low
grade
and
patent).
Prior
to
analysis,
the
grain
and
processed
fractions
were
stored
frozen
for
up
to
4.9
months,
an
interval
supported
by
the
available
stability
data.
Combined
residues
were
determined
using
GC/
ECD
Method
AG­
454B,
which
was
adequately
validated
in
conjunction
with
the
analysis
of
treated
samples.
The
validated
method
LOQ
is
0.05
ppm
for
each
commodity,
and
the
LOD
was
0.02
ppm.

For
the
tests
conducted
at
the
0.5x
rate,
total
propiconazole
residues
were
<
LOQ
in/
on
all
samples
of
grain
and
all
processed
fractions,
with
the
exception
of
AGF.
AGF
samples
from
the
0.5x
applications
were
<
LOQ
in
one
test
and
0.08­
0.14
ppm
in
the
remaining
three
1x
tests,
indicating
the
potential
for
concentration
of
residues
in
AGF.
However,
reliable
processing
factors
could
not
be
calculated
since
residues
in
the
RAC
were
<
LOQ.

Residues
were
also
<
LOQ
in/
on
grain
samples
from
two
of
the
tests
conducted
at
2.5x
rates;
however,
in
the
remaining
two
2.5x
tests,
residues
in/
on
grain
were
0.16
ppm
at
67
DAT
and
0.24
ppm
at
57
DAT.
In
these
tests,
residues
were
1.3­
1.4
ppm
in
AGF,
 
0.06
ppm
in
germ,
0.05­
0.17
ppm
in
bran,
and
<
LOQ
in
middlings,
shorts
and
flour.
Calculated
processing
factors
for
these
tests
were
5.8­
8.1x
for
AGF,
 
0.3x
for
germ,
0.3­
0.7x
for
bran,
 
0.2x
for
middlings,
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
47
of
63
shorts
and
flour.
Average
processing
factors
were
7.0x
for
AGF,
0.2x
for
germ,
0.5x
for
bran
and
<
0.1x
for
middlings,
shorts
and
flour.

In
the
final
series
of
wheat
processing
studies
conducted
in
1997
(
44757208.
der2),
propiconazole
was
applied
at
the
highest
use
rates
and
at
the
latest
possible
timing.
In
two
trials,
propiconazole
(
EC)
was
applied
to
wheat
in
four
separate
plots
as
either
a
single
broadcast
foliar
application
at
Feekes
Growth
Stage
10.5
at
0.11­
12
lb
ai/
A
(
0.5x
rate),
or
as
two
broadcast
foliar
applications
around
Feekes
Growth
Stages
10
(
booting)
and
10.5
(
heading)
at
either
0.11­
0.12,
0.33­
0.37,
or
0.55­
0.62
lb
ai/
A/
application,
for
totals
of
~
0.22,
~
0.66,
and
~
1.1
lb
ai/
A/
season
(
1x,
3x
and
5x
rates).
All
applications
were
made
using
ground
equipment
in
volumes
of
19­
20
gal/
A,
and
no
adjuvants
were
included
in
the
spray
mixture.
The
RTI
was
12
or
16
days
for
plots
receiving
two
applications.
Single
control
and
treated
bulks
samples
of
grain
were
harvested
from
each
test
at
36
or
47
DAT.
Samples
were
cleaned
to
generate
AGF
and
then
processed
using
simulated
commercial
procedures
into
wheat
germ,
bran,
middlings,
shorts
and
flour
(
low
grade
and
patent).
Samples
were
stored
up
to
9.3
months
prior
to
analysis,
an
interval
supported
by
available
storage
stability
data.

Combined
residues
were
determined
using
GC/
ECD
Method
AG­
454B,
which
was
adequately
validated
in
conjunction
with
the
analysis
of
treated
samples.
The
validated
method
LOQ
is
0.05
ppm
for
each
commodity,
and
the
LOD
was
0.02
ppm.
In
addition,
samples
from
these
processing
studies
were
also
analyzed
for
residues
of
propiconazole,
per
se,
using
a
GC/
NPD
method
from
PAM
Vol.
I
(
Method
302
E4
+
DG5).
This
method
was
also
adequately
validated
in
conjunction
with
the
analysis
of
treated
samples,
and
the
validated
method
LOQ
was
0.05
ppm
for
all
wheat
commodities;
a
LOD
was
not
reported.

Following
a
single
broadcast
application
to
wheat
at
a
0.5x
rate
at
FGS
10.5,
total
combined
residues
were
<
LOQ
in/
on
mature
samples
of
grain
harvested
at
either
36
or
47
DAT.
Following
two
broadcast
applications
at
approximately
Feekes
Growth
Stages
(
FGS)
10
and
10.5,
combined
residues
in/
on
grain
were
<
0.05
and
0.062
ppm
from
the
1x
rate
tests,
0.101
and
0.129
ppm
from
the
3x
rate
tests,
and
0.107
and
0.183
ppm
from
the
5x
rate
tests.
Within
each
test,
levels
of
combined
residues
were
typically
highest
in
AGF
and
then
bran,
and
residues
were
lowest
in
flour.
Processing
factors
were
calculated
only
for
those
tests
in
which
residues
were
 
LOQ
in/
on
whole
grain.
For
these
tests,
average
processing
factors
for
total
combined
residues
were
0.9x
for
germ,
3.2x
for
bran,
0.7x
for
middlings,
0.9x
for
shorts,
and
<
0.3x
for
flour.
The
maximum
theoretical
processing
factor
for
wheat
is
8.3x.
Processing
factors
for
combined
residues
in
AGF
varied
considerably
between
the
two
test
sites,
averaging
2.7x
at
the
OK
site
and
34x
at
the
KS
site,
for
an
overall
processing
factor
of
18x.

Regardless
of
the
application
timing
to
wheat,
all
of
the
above
wheat
processing
studies
indicate
that
there
is
the
potential
for
substantial
concentration
of
combined
propiconazole
residues
in
wheat
AGF
and
to
a
lesser
extent
in
bran.
Total
combined
residues
were
either
reduced
or
concentrated
only
slightly
in
germ,
shorts,
middlings,
and
flour;
therefore,
separate
tolerances
are
not
required
for
these
wheat
commodities.
As
the
final
series
of
processing
studies
(
44757208.
der2)
reflected
the
latest
proposed
application
timing
and
had
the
highest
levels
of
residues
in
the
RAC,
the
average
processing
factors
from
these
tests
will
be
used
to
estimate
maximum
potential
residues
in
AGF
(
18x)
and
bran
(
3.2x).
Using
these
processing
factors
and
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
48
of
63
the
HAFT
residues
in
wheat
grain
(
0.18
ppm)
reflecting
applications
at
up
to
Feekes
Growth
Stage
10.5,
the
maximum
expected
combined
residues
would
be
3.2
ppm
in
wheat
AGF
and
0.58
ppm
in
wheat
bran.

Conclusions
Adequate
processing
studies,
reflecting
the
measurement
of
total
combined
residues,
are
available
for
alfalfa
(
rotational
crop),
field
corn,
mint,
rice,
sorghum,
soybean,
sugar
beet,
and
wheat.
Adequate
processing
data
are
also
available
from
one
of
the
wheat
processing
studies
reflecting
the
measurement
of
only
parent
residues.

These
studies
indicate
that,
with
the
exception
of
AGF,
combined
propiconazole
residues
did
not
concentrate
in
processed
commodities
derived
from
alfalfa,
field
corn,
mint,
sorghum,
and
soybeans,
or
in
polished
rice,
sugar
beet
refined
sugar,
or
wheat
germ,
shorts,
middlings
and
flour.
However,
combined
residues
were
shown
to
concentrate
in
rice
hulls
(
3.8x)
and
bran
(
2.9x),
sugar
beet
molasses
(
7.4x)
and
dried
pulp
(
4.9x),
and
wheat
bran
(
3.2x).
Therefore
separate
tolerances
are
required
for
these
commodities.
Considering
the
HAFT
residues
in
the
various
RACs
and
the
above
processing
factors,
appropriate
tolerances
for
combined
propiconazole
residues
would
be
20
and
15
ppm
for
rice
hulls
and
bran,
1.5
and
1.0
ppm
for
sugar
beet
molasses
and
dried
pulp,
and
0.6
ppm
for
wheat
bran.

With
regards
to
AGF,
combined
residues
were
shown
to
concentrate
by
various
degrees
in
AGF
derived
from
field
corn
(
12.8x),
sorghum
(
5.2x),
soybeans
(
32x),
and
wheat
(
13x)
following
late
season
applications.
Considering
these
AGF
processing
factors
and
the
HAFT
residues
in
the
respective
RACs,
the
maximum
excepted
residues
in
AGF
are
1.28
ppm
for
corn,
10.9
ppm
for
sorghum,
30
ppm
for
soybean,
and
4.14
ppm
for
wheat.
Therefore,
the
tolerance
for
combined
propiconazole
residues
in
AGF
should
be
set
at
30
ppm
based
on
the
soybean
data.

860.1650
Submittal
of
Analytical
Reference
Standards
An
analytical
reference
standard
for
propiconazole
is
available
at
the
EPA
National
Pesticide
Standards
Repository.

860.1850/
860.1900
Confined
and
Field
Accumulation
in
Rotational
Crops
Propiconazole
RED,
DP
Barcode
D329394,
Y.
Donovan,
6/
15/
06
43640401.
der3
(
alfalfa)

The
nature
of
the
residue
in
confined
rotational
crops
is
understood.
Based
on
acceptable
studies
reviewed
by
EFED,
the
metabolism
of
propiconazole
in
rotational
crops
is
similar
to
that
in
primary
crops.
Plant­
back
restrictions
have
been
established
for
propiconazole
products
registered
for
use
on
rotational
crops
based
on
the
confined
rotational
crop
studies.
Labels
specify
that
any
food/
feed
crops
not
listed
on
the
label
should
not
be
planted
within
105
days
of
treatment.

Syngenta
has
previously
proposed
tolerances
(
PP#
5F4498)
for
inadvertent
residues
on
sorghum
and
alfalfa
planted
in
rotation
with
propiconazole­
treated
wheat.
However,
this
petition
has
been
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
49
of
63
superseded
by
PP#
2F6371,
in
which
Syngenta
is
now
proposing
the
direct
use
of
propiconazole
on
sorghum.
Once
tolerances
for
the
direct
use
on
sorghum
are
established,
rotational
crop
tolerances
on
sorghum
commodities
will
no
longer
be
necessary.
With
regards
to
alfalfa,
Syngenta
is
still
supporting
a
proposed
0.1
ppm
tolerance
for
alfalfa,
based
on
its
rotation
with
propiconazole­
treated
wheat,
and
has
submitted
field
trial
data
depicting
combined
residues
in/
on
forage
and
hay
from
alfalfa
rotated
with
propiconazole­
treated
wheat.
These
data
are
summarized
in
Table
8
and
discussed
below.
Table
8.
Summary
of
Residue
Data
in
Alfalfa
Forage
and
Hay
Rotated
at
a
PBI
of
~
75
days
with
Propiconazole­
Treated
Wheat.
Combined
Propiconazole
Residues
(
ppm)
2
Commodity
Total
Applic.
Rate
(
lb
ai/
A)
PBI
(
days)
DAP
1
n
Min.
Max.
HAFT
3
Median
(
STMdR)
4
Mean
(
STMR)
4
Std.
Dev.

Fall
Forage
60­
63
8
<
0.05
0.07
0.07
0.05
0.04
0.02
Spring
Forage
10
<
0.05
0.07
0.05
0.03
0.04
0.02
Spring
Hay
0.11
(
0.5x)
5
72­
109
269­
333
10
<
0.05
0.08
0.06
0.04
0.04
0.02
Fall
Forage
60­
63
2
<
0.05
0.07
0.07
0.05
0.05
0.03
Spring
Forage
2
<
0.05
<
0.05
0.03
0.03
0.03
0.00
Spring
Hay
0.22
(
1x)
72­
77
303­
333
3
<
0.05
0.07
0.07
0.06
0.05
0.02
Fall
Forage
60­
63
2
<
0.05
0.06
0.06
0.04
0.04
0.02
Spring
Forage
2
<
0.05
0.07
0.07
0.05
0.05
0.03
Spring
Hay
0.33
(
1.5x)
72­
77
303­
333
3
<
0.05
0.09
0.08
0.06
0.06
0.03
Fall
Forage
60­
63
2
0.10
0.14
0.14
0.12
0.12
0.03
Spring
Forage
2
<
0.05
0.06
0.06
0.04
0.04
0.02
Spring
Hay
0.55
(
2.5x)
72­
77
303­
333
3
<
0.05
0.09
0.09
0.08
0.07
0.04
1
DAP
=
days
after
planting.
Forage
was
collected
the
fall
following
planting
(
60­
63
DAP)
and
forage
and
hay
were
collected
the
following
spring
(
269­
333
DAP).
2
The
LOQ
for
propiconazole
residues
in/
on
alfalfa
is
0.05
ppm.
The
LOD
was
not
reported.
3
HAFT
=
Highest
Average
Field
Trial.
4
STMdR
=
Supervised
Trial
Median
Residue;
STMR
=
Supervised
Trial
Mean
Residue.
For
calculation
of
the
median,
mean
and
standard
deviation,
2
the
LOQ
was
used
for
residues
reported
at
<
LOQ.
5
The
maximum
seasonal
application
rate
is
0.22
lb
ai/
A
for
wheat
and
other
small
cereal
grains
(
oats,
barley,
rye).

Alfalfa
Five
rotational
crop
field
trials
were
conducted
on
alfalfa
in
1989
in
Regions
1,
5
and
11.
At
each
site,
propiconazole
(
3.6
lb/
gal
EC)
was
applied
at
0.11
lb
ai/
A
to
winter
wheat
in
the
spring
as
a
single
broadcast
foliar
application
at
Feekes
Growth
Stages
7­
9.
Two
of
the
test
sites
also
had
additional
plots
with
application
rates
at
0.22,
0.33
and
0.55
lb
ai/
A.
These
application
rates
correspond
to
0.5x,
1x,
1.5x,
and
2.5x
the
maximum
proposed
application
rate
for
wheat.
All
applications
were
made
using
ground
equipment
at
volumes
of
15­
23
gal/
A.
The
wheat
was
grown
to
maturity
and
harvested,
and
a
rotational
crop
of
alfalfa
was
replanted
the
same
year
at
PBIs
of
72­
109
days
and
was
grown
using
standard
agricultural
practices.
A
single
control
and
single
or
duplicate
treated
samples
of
forage
were
cut
in
the
fall
at
60­
63
days
after
planting
(
DAP),
and
alfalfa
forage
and
hay
samples
also
collected
the
following
spring
at
269­
333
DAP.
Samples
were
stored
frozen
for
up
to
35
months,
an
interval
supported
by
available
storage
stability
data.

Residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
in/
on
alfalfa
forage
and
forage
were
determined
using
GC/
ECD
Method
AG­
454
B,
which
was
adequately
validated
in
conjunction
with
the
analysis
of
field
trial
samples.
The
validated
method
LOQ
is
0.05
ppm,
and
an
LOD
was
not
reported.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
50
of
63
Following
a
single
application
of
propiconazole
(
EC)
at
0.11
lb
ai/
A
(
0.5x
rate)
to
a
primary
crop
of
winter
wheat
in
5
tests,
total
propiconazole
residues
in
rotational
alfalfa
forage
and
hay
from
PBIs
of
72­
109
days
were
<
0.05­
0.07
ppm
in
forage
(
fall
and
spring)
and
<
0.05­
0.08
ppm
in
hay.
Average
residues
were
0.04
ppm
in
both
alfalfa
forage
and
hay
at
the
0.5x
rate.
At
the
1x
rate,
residues
were
<
0.05­
0.07
ppm
in
forage
and
hay.
At
the
1.5x
rate,
residues
were
<
0.05­
0.07
ppm
in
forage
and
<
0.05­
0.09
ppm
in
hay.
At
the
2.5x
rate,
residues
were
0.10­
0.14
ppm
in
the
initial
fall
forage
and
<
0.05­
0.06
ppm
in
spring
forage
and
<
0.05­
0.09
ppm
in
spring
hay.

Conclusions
The
field
rotational
crop
trials
on
alfalfa
are
adequate
and
will
support
a
75­
day
PBI
for
alfalfa
following
primary
crops
treated
with
propiconazole
at
rates
totaling
up
to
0.22
lb
ai/
A/
season.

860.1550
Proposed
Tolerances
Permanent
tolerances
are
currently
established
for
the
combined
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
at
levels
ranging
from
0.1­
40
ppm
in/
on
plant
commodities
[
40
CFR
§
180.434(
a)].
Permanent
tolerances
are
also
established
for
the
combined
residues
of
propiconazole
and
its
2,4­
DCBA
containing
metabolites
at
0.1
ppm
in
fat,
meat,
and
meat
byproducts
(
except
liver
and
kidney)
of
livestock,
2.0
ppm
in
liver
and
kidney
of
livestock,
and
at
0.05
ppm
in
milk;
however,
no
tolerances
have
been
established
for
eggs
and
poultry
commodities.
Time­
limited
tolerances
are
established
for
combined
propiconazole
residues
in/
on
a
variety
of
plant
commodities
at
levels
from
0.2
ppm
in/
on
sorghum
grain
to
25
ppm
in/
on
soybean
hay
[
40
CFR
§
180.434(
b)].
In
addition,
tolerances
with
regional
restrictions
have
been
established
for
combined
propiconazole
residues
at
0.3
ppm
in/
on
mint
tops
and
0.5
ppm
in/
on
wild
rice
[
40
CFR
§
180.434(
c)].
However,
HED
has
determined
that
the
current
tolerance
expression
for
plant
and
animal
commodities
is
not
appropriate
and
has
recommended
that
the
tolerance
expression
be
revised
to
include
only
parent.

The
tolerances
proposed
by
Syngenta
and
IR­
4
for
the
current
petitions
and
established
tolerances
are
listed
in
Table
9,
along
with
the
Agency's
new
recommended
tolerance
levels.
Although
HED
has
recommended
changing
the
tolerance
expression
to
include
only
parent,
the
majority
of
residue
data
submitted
in
support
of
the
current
petitions
were
generated
using
common
moiety
methods,
which
do
not
differentiate
between
parent
and
its
DCBA
containing
metabolites.
Therefore,
the
recommended
tolerances
based
on
these
data
will
overestimate
actual
propiconazole
residues.
The
recommended
tolerance
levels
for
RACs
in
the
current
petitions
were
determined
using
recent
Agency
Guidance
(
Guidance
for
Setting
Pesticide
Tolerances
Based
on
Field
Trial
Data
SOP),
with
the
exception
of
commodities
having
substantial
( 
15%)
numbers
of
residue
values
below
the
method
LOQ.
For
those
commodities
with
large
numbers
of
values
<
LOQ
(
corn
grain,
dry
bulb
onions,
sugar
beet
roots,
tree
nuts,
and
wheat
grain),
the
recommended
tolerance
was
based
on
the
observed
maximum
residue
value.
For
those
commodities
for
which
the
tolerance
spreadsheet
was
used
to
calculate
the
appropriate
tolerance
level,
the
residue
data
used
for
the
tolerance
calculations
and
the
supporting
spreadsheet
outputs
are
presented
in
Appendix
II.
HED
also
recommends
using
the
recommended
tolerance
levels
for
conducting
dietary
risk
assessment.
Although
in
some
cases
where
uncorrected
raw
data
were
used
in
deriving
these
tolerances
(
with
average
recoveries
around
70%),
but
since
this
is
a
tier
I
DEEM
assessment,
it
will
not
under
estimate
the
risk.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
51
of
63
For
purposes
of
determining
tolerances,
adequate
field
trial
data
are
available
for
alfalfa
(
rotational
crop),
almonds,
celery,
bush
and
cane
berries,
carrots,
corn
(
field,
pop,
and
sweet),
cranberries,
mint,
onions,
pecans,
rice,
sorghum,
soybean
(
hay
and
forage
only),
strawberries,
sugar
beet
roots,
and
wheat.
The
available
almond
and
pecan
data
will
support
a
crop
group
tolerance
on
tree
nuts,
and
separate
tolerances
pistachios
and
almond
hulls.
The
celery
data
will
support
a
subgroup
tolerance
on
leafy
petiole
vegetables,
and
the
bush
and
cane
berry
data
will
support
a
crop
group
tolerance
on
the
berries
crop
group.
In
addition,
the
recommended
separate
tolerances
on
green
and
dry
bulb
onions
will
cover
the
other
members
of
the
bulb
vegetable
crop
group.

Based
on
the
different
use
patterns
and
resulting
residues
in/
on
the
various
cereal
grains,
a
crop
group
tolerance
is
not
appropriate
for
cereal
grain
and
separate
tolerances
should
be
established
for
each
member
of
the
crop
group
with
labeled
uses.
Adequate
field
trial
data
are
available
for
corn,
rice,
sorghum,
and
wheat.
However,
tolerances
for
corn
must
be
separated
out
for
the
specific
types
of
corn.
The
recent
field
corn
data
will
support
the
recommended
tolerances
for
field
and
pop
corn
commodities
and
sweet
corn
stover,
and
the
previously
reviewed
sweet
corn
data
(
PP#
8F3674,
C.
Deyrup,
12/
14/
88)
will
support
the
current
tolerance
of
0.1
ppm
for
sweet
corn
(
kernels
plus
cobs
with
husks
removed)
along
with
a
lower
tolerance
(
6
ppm)
for
sweet
corn
forage.
The
most
recent
wheat
field
trial
data
will
be
used
to
set
wheat
tolerances
and
will
also
be
translated
to
set
new
tolerances
on
barley
and
rye
commodities.
As
the
proposed
changes
to
the
label
directions
will
also
cover
oats,
the
wheat
residue
data
will
also
be
translated
to
oats
to
reassess
the
existing
tolerances
on
oats.

Although
adequate
residue
data
are
available
to
support
tolerances
on
sugar
beet
roots,
additional
residue
data
are
required
before
permanent
tolerances
can
be
established
for
sugar
beet
tops
if
the
petitioner
wants
to
use
EC
formulation.
HED
recommends
a
conditional
tolerance
be
established
on
sugar
beet
tops.

There
are
no
sufficient
residue
data
to
establish
a
permanent
tolerance
on
the
dry
pea
and
bean
subgroup.
HED
recommends
against
the
establishment
of
permanent
tolerance
on
dry
peas
and
beans
(
subgroup
6C)
until
additional
field
trials
data
are
submitted.

Adequate
processing
studies
are
available
for
alfalfa,
corn,
mint,
rice,
sorghum,
soybeans,
sugar
beets
and
wheat.
The
only
processed
commodities
which
shown
to
have
substantial
concentrations
of
combined
residues
were
rice
bran
(
2.9x)
and
hulls
(
3.8x),
sugar
beet
molasses
(
7.4x)
and
dried
pulp
(
3.9x),
and
wheat
bran
(
3.2x).
Tolerances
for
these
commodities
were
estimated
based
on
maximum
expected
residues
calculated
using
HAFT
residues
and
the
above
processing
factors.
The
tolerances
for
wheat
bran
will
be
translated
to
barley
and
rye
bran.

The
available
corn,
sorghum,
soybean
and
wheat
processing
studies
all
indicated
that
there
is
the
potential
for
concentration
of
combined
residues
in
AGF
from
all
four
crops.
Following
the
proposed
late
season
applications,
processing
factors
for
AGF
were
12.8x
for
field
corn,
5.2x
for
sorghum,
32x
for
soybeans,
and
13x
for
wheat
(
13x).
Considering
these
AGF
processing
factors
and
the
HAFT
residues
in
the
respective
RACs,
the
maximum
excepted
residues
in
AGF
are
1.28
ppm
for
corn,
10.9
ppm
for
sorghum,
30
ppm
for
soybean,
and
4.14
ppm
for
wheat.
Therefore,
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
52
of
63
the
tolerance
for
combined
propiconazole
residues
in
AGF
should
be
set
at
30
ppm
based
on
the
soybean
data.

To
assess
livestock
tolerances,
total
combined
residues
were
estimated
for
a
1x
feeding
level
using
the
data
on
combined
residues
from
the
available
cattle
and
poultry
feeding
studies;
For
beef
cattle,
estimated
combined
residues
at
a
1x
feeding
level
are
1.7
ppm
for
kidney,
1.6
ppm
for
liver,
0.03
ppm
for
muscle,
0.05
ppm
for
fat,
and
0.03
pm
for
milk.
For
swine,
estimated
combined
residues
at
a
1x
feeding
level
are
0.14ppm
for
kidney,
0.13
ppm
for
liver
and
<
0.005
ppm
for
muscle
and
fat.
HED
recommends
that
the
following
tolerance
levels
be
established:
For
cattle,
goat,
horses
and
sheep,
kidney
and
liver
at
2.0
ppm;
meat
and
meat
byproduct
(
except
kidney
and
liver)
and
fat
at
0.05
ppm,
milk
at
0.05
ppm.
For
hog,
kidney
and
liver
at
0.20
ppm,
no
tolerances
are
needed
for
meat,
fat,
and
meat
byproduct.

For
poultry
tissues
and
eggs,
estimated
combined
residues
and
parent
residues
were
calculated
in
the
same
manner
as
for
cattle
and
swine.
The
maximum
combined
residues
in
tissues
and
eggs
from
the
7.5­
ppm
dose
group
in
the
poultry
feeding
study
were
used
to
estimate
residues
at
the
1x
feeding
level.
The
estimated
combined
residues
at
the
1x
feeding
level
are
all
<
LOQ.
Therefore,
tolerances
for
poultry
tissues
and
eggs
are
not
required
as
quantifiable
levels
of
propiconazole
are
unlikely
to
occur
in
these
commodities
[
40
CFR
180.6(
a)
(
3)].

The
Agency
notes
that
these
recommended
tolerance
revisions
are
relatively
conservative,
as
they
are
based
on
combined
residues
instead
of
propiconazole,
per
se.

The
Codex
Alimentarius
Commission
has
established
several
maximum
residue
limits
(
MRLs)
for
propiconazole
in/
on
various
raw
agricultural
commodities.
The
Codex
MRLs
are
expressed
in
terms
of
propiconazole
per
se,
which
is
the
same
as
the
US
tolerance
expression,
recommended
by
the
RED
for
existing
tolerances
and
for
the
new
uses
in
the
present
action.
In
addition,
both
Canada
and
Mexico
have
established
MRLs/
tolerances
on
several
commodities
which
also
have
U.
S.
tolerances.
To
the
extent
possible,
U.
S.
tolerances
have
been
harmonized
with
Codex,
Canadian,
and
Mexican
MRLs;
however,
differences
in
use
patterns
and
the
supporting
residue
data
have
precluded
reducing
many
tolerances.
A
comparison
of
Codex
MRLs,
Canadian
MRLs,
and
Mexican
tolerances
and
the
corresponding
U.
S.
tolerances
is
presented
in
Appendix
I.
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
53
of
63
Table
9.
Tolerance
Summary
for
Propiconazole
Crop
Commodity
Proposed
or
(
Established)
Tolerance
(
ppm)
6
HED
Recommend
ed
Tolerance
(
ppm)
Comments
(
Correct
Commodity
Definition)
Tolerances
under
§
180.434(
a)

AGF
17
30
Based
on
the
maximum
expected
residues
in
AGF
from
corn
(
1.28
ppm),
sorghum
(
10.9
ppm),
soybeans
(
44.8
ppm),
and
wheat
(
4.14
ppm),
the
tolerance
for
AGF
should
be
based
on
the
available
soybean
data.
Grain,
aspirated
fractions
Alfalfa
0.1
None
As
the
tolerance
is
for
rotated
alfalfa,
it
should
be
established
under
§
180.434(
d)
for
inadvertent
residues
Almond,
hulls
8.0
7.0
1
Adequate
data
are
available.
Almond,
hulls
Banana
(
0.2)
0.2
The
existing
tolerance
is
adequate
Barley,
grain
0.5
0.3
Barley,
hay
2.0
1.4
Barley,
straw
13
10
Barley,
bran
2.5
0.6
Tolerances
for
barley
commodities
are
based
on
residue
data
translated
from
wheat.

Cattle,
fat
(
0.1)
0.05
Cattle,
kidney
(
2.0)
2.0
Cattle,
liver
(
2.0)
2.0
Cattle,
meat
(
0.1)
0.05
Cattle,
meat
byproducts,
except
liver
and
kidney
(
0.1)
0.05
The
recalculated
MTDB
for
beef
cattle
(
28
ppm).
Estimated
combined
residues
are:
1.7
ppm
in
kidney,
1.6
ppm
in
liver,
0.03
ppm
in
muscle,
0.05
ppm
in
fat.

Celery
(
5.0)
Delete
Once
the
tolerance
of
the
leaf
petioles
subgroup
is
established
the
separate
tolerance
on
celery
should
be
deleted
Crop
Subgroup
4­
B,
leaf
petioles
5.0
5.0
1
The
available
residue
data
on
celery
will
support
the
5
ppm
tolerance
on
Vegetable,
leaf
petioles,
subgroup
4B
Crop
Subgroup
6­
C,
Dried
shelled
peas
and
bean
(
except
soybean)
0.5
none
5
Insufficient
residue
data
to
support
a
tolerance
on
the
Pea
and
bean,
dried
shelled,
except
soybean,
subgroup
6C
Crop
Group
13­
Berries
Group
1.0
1.0
1
Adequate
residue
data
are
available
on
blueberries,
black
berries,
and
raspberries
to
support
a
tolerance
for
Berry,
group
13
Carrot
0.2
0.25
1
Adequate
residue
data
are
available.
Carrot,
root
Corn,
field,
forage
4.0
12
Adequate
residue
data
are
available
supporting
a
30­
day
PHI
for
field
corn
forage
following
applications
totaling
0.44
lb
ai/
A.
Corn,
field,
forage
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
54
of
63
Table
9.
Tolerance
Summary
for
Propiconazole
Crop
Commodity
Proposed
or
(
Established)
Tolerance
(
ppm)
6
HED
Recommend
ed
Tolerance
(
ppm)
Comments
(
Correct
Commodity
Definition)

Corn,
sweet,
forage
none
6.0
3
A
separate
tolerance
should
be
established
for
sweet
corn
forage.
Based
on
the
available
sweet
corn
field
trials,
in
which
maximum
residues
were
5.0
ppm
in/
on
forage
from
a
test
conducted
at
a
0.9x
rate,
a
6.0
ppm
tolerance
should
be
established
for
residues
in/
on
Corn,
sweet,
forage.

Corn,
field,
grain
0.3
0.2
2
Adequate
residue
data
are
available
supporting
the
reduced
30­
day
PHI.
Corn,
field,
grain
Corn,
pop,
grain
none
0.22
Adequate
residue
data
are
available
supporting
the
reduced
30­
day
PHI.
Corn,
pop,
grain
Corn,
sweet,
K+
CWHR
None
0.1
Adequate
residue
data
are
available
supporting
the
existing
tolerance.
Corn,
sweet,
K+
CWHR
Corn,
stover
25
30
1
Adequate
residue
data
are
available
supporting
the
reduced
30­
day
PHI.

Corn,
pop,
stover
None
30
1
Based
on
the
field
corn
stover
data.

Corn,
sweet,
stover
none
30
1
Based
on
the
field
corn
stover
data.

Corn,
oil
0.5
None
Processing
factors
for
corn
oil
were
0.6x­
1.6x
and
averaged
1x;
therefore,
a
separate
tolerance
is
not
required
for
corn
oil
Fruit,
stone,
group
12
None
1.0
Tolerance
was
reassessed
by
the
Agency
(
HED
memo
of
propiconazole
RED,
6/
28/
06,
Y.
Donovan,
D329668).
Goat,
fat
(
0.1)
0.05
Goat,
kidney
(
2.0)
2.0
Goat,
liver
(
2.0)
2.0
Goat,
meat
(
0.1)
0.05
Goat,
meat
byproducts,
except
liver
and
kidney
(
0.1)
0.05
See
comments
under
cattle.

Grass,
forage
(
0.5)
0.5
Grass,
hay
(
0.5)
0.5
Grass,
straw
(
40)
40
The
existing
tolerances
are
adequate.
The
existing
tolerances
are
adequate.
(
HED
memo
of
propiconazole
RED,
6/
28/
06,
Y.
Donovan,
D329668).
Hog,
fat
(
0.1)
Delete
Hog,
kidney
(
2.0)
0.2
Hog,
liver
(
2.0)
0.2
Hog,
meat
(
0.1)
Delete
The
recalculated
MTDB
for
swine
(
2.3
ppm)
and
estimated
residues
in
liver
(
0.13
ppm),
kidney
(
0.14
ppm),
muscle
(<
0.005
ppm)
and
fat
(
0.005
ppm)
at
a
1x
feeding
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
55
of
63
Table
9.
Tolerance
Summary
for
Propiconazole
Crop
Commodity
Proposed
or
(
Established)
Tolerance
(
ppm)
6
HED
Recommend
ed
Tolerance
(
ppm)
Comments
(
Correct
Commodity
Definition)
Hog,
meat
byproducts,
except
liver
and
kidney
(
0.1)
Delete
level.

Horse,
fat
(
0.1)
0.05
Horse,
kidney
(
2.0)
2.0
Horse,
liver
(
2.0)
2.0
Horse,
meat
(
0.1)
0.05
Horse,
meat
byproducts,
except
liver
and
kidney
(
0.1)
0.05
See
comments
under
cattle.

Mint,
spearmint,
tops
3.0
3.5
1
Adequate
data
are
available.
Mint,
peppermint,
tops
3.0
3.5
1
Adequate
data
are
available.

Milk
(
0.05)
0.05
MTDB
for
dairy
cattle
is
18.5
ppm.
The
estimated
combined
residue
on
milk
at
1x
MTDB
based
on
feeding
study
is
0.03
ppm.
Mushroom
(
0.1)
0.1
The
existing
tolerance
is
adequate.
Oats,
forage
10.0
1.7
Oats,
grain
0.1
0.32
Oats,
hay
30.0
1.4
Oats,
straw
1.0
10
As
the
proposed
changes
to
the
label
directions
will
also
cover
oats
in
addition
to
wheat,
the
wheat
residue
data
will
also
be
translated
to
oats
to
reassess
the
existing
tolerances.

Onion,
bulb
0.3
0.2
2
Adequate
residue
data
are
available.
Maximum
combined
residues
were
0.18
ppm
in/
on
dry
bulb
onions.
Onion,
dry
bulb
Onion,
green
8.0
9.0
1
Adequate
residue
data
are
available.
Onion,
green
Peanut,
nut
meat
(
0.2)
0.2
Peanut,
hay
(
20)
20
The
existing
tolerances
are
adequate.

Pecans
(
0.1)
Delete
Once
the
tree
nut
crop
group
tolerance
is
established,
the
separate
tolerance
for
pecans
should
be
deleted
Pineapple
(
0.1)
0.1
The
existing
tolerance
is
adequate.

Pistachio
0.2
0.1
Tolerance
is
based
on
residue
data
from
almonds
and
pecans
Rice,
bran
28
15
Based
on
HAFT
residues
of
5.05
ppm
for
rice
grain
and
an
average
processing
factor
of
2.9x
for
bran,
the
maximum
expected
residues
in
bran
would
be
14.6
ppm.
Rice,
bran
Rice,
grain
7.0
7.0
4
Adequate
field
trial
data
are
available.
Rice,
grain
Rice,
hulls
28
20
Based
on
HAFT
residues
of
5.05
ppm
for
rice
grain
and
an
average
processing
factor
of
3.8x
for
hulls,
the
maximum
expected
residues
in
hulls
would
be
19.2
ppm.
Rice,
hulls
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
56
of
63
Table
9.
Tolerance
Summary
for
Propiconazole
Crop
Commodity
Proposed
or
(
Established)
Tolerance
(
ppm)
6
HED
Recommend
ed
Tolerance
(
ppm)
Comments
(
Correct
Commodity
Definition)

Rice,
straw
18
18
1
Adequate
field
trial
data
are
available.
Rice,
straw
Rye,
grain
0.5
0.3
Rye,
forage
3.0
1.7
Rye,
straw
13
10
Rye,
bran
2.5
0.6
Tolerances
for
rye
commodities
are
based
on
residue
data
translated
from
wheat.

Grain
sorghum,
forage
10
12
1
Grain
sorghum,
grain
2.5
3.5
1
Grain
sorghum,
(
stover)
15
15
1
Adequate
field
trial
data
are
available
for
sorghum.
Sorghum,
grain,
forage;
Sorghum,
grain;
and
Sorghum,
grain,
stover
Sheep,
fat
(
0.1)
0.05
Sheep,
kidney
(
2.0)
2.0
Sheep,
liver
(
2.0)
2.0
Sheep,
meat
(
0.1)
0.05
Sheep,
meat
byproducts,
except
liver
and
kidney
(
0.1)
0.05
See
comments
under
cattle.

Soybean,
forage
8.0
11
1
Soybean,
hay
32
30
1
Adequate
field
trial
data
are
available
at
the
1x
rate
to
support
a
30­
day
PHI
for
Soybean,
forage
and
Soybean,
hay
Soybean,
seed
2.0
2.0
Field
trial
data
are
available
to
support
Soybean
seed
following
applications
up
to
Stage
R6.

Strawberry
1.5
1.3
1
Adequate
residue
data
are
available.
Strawberry
Sugar
beet,
dried
pulp
2.0
1.0
Based
on
HAFT
residues
of
0.18
ppm
for
roots
and
a
4.9x
processing
factor
for
dried
pulp,
maximum
expected
residues
in
dried
pulp
would
be
0.88
ppm.
Beet,
sugar,
dried
pulp
Sugar
beet,
roots
0.3
0.3
2
Adequate
residue
data
are
available
and
indicate
that
there
is
no
difference
in
residue
levels
in/
on
roots
between
the
WP
and
EC
formulations.
Tolerance
in
based
on
maximum
residues
of
0.23
ppm
in/
on
roots
Beet,
sugar,
roots
Propiconazole
Summary
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and
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D238458
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Table
9.
Tolerance
Summary
for
Propiconazole
Crop
Commodity
Proposed
or
(
Established)
Tolerance
(
ppm)
6
HED
Recommend
ed
Tolerance
(
ppm)
Comments
(
Correct
Commodity
Definition)

Sugar
beet,
tops
10
10
5
Adequate
residue
data
are
available
for
the
WP
formulation
and
suggest
a
tolerance
level
of
4.5
ppm.
However,
the
limited
field
trial
data
for
the
EC
formulation
indicate
that
a
higher
tolerance
is
required.
A
tolerance
should
be
set
at
10
ppm,
with
the
registration
conditioned
upon
the
submission
of
additional
residue
data
on
tops
for
the
EC
formulation.
Beet,
sugar,
tops.

Sugar
beet,
molasses
3.0
1.5
Based
on
HAFT
residues
of
0.18
ppm
for
roots
and
a
7.4x
processing
factor
for
molasses,
maximum
expected
residues
in
molasses
would
be
1.33
ppm.
Beet,
sugar,
molasses
Tree
nuts
crop
group
0.2
0.12
Adequate
residue
data
are
available
on
pecans
and
almonds.
Tolerance
is
based
on
maximum
residues
of
0.09
ppm
for
almonds
and
<
0.1
ppm
for
pecans.
Nut,
tree,
group
14
Wheat,
bran
2.5
0.6
Based
on
HAFT
combined
residues
of
0.18
ppm
for
wheat
grain
and
an
average
3.2x
processing
factor
for
wheat
bran,
maximum
expected
residues
in
bran
would
be
0.58
ppm.
Wheat,
bran
Wheat,
forage
3.0
1.71
Adequate
residue
data
are
available
to
support
only
a
single
application
prior
to
the
harvest
of
Wheat,
forage.

Wheat,
grain
0.5
0.3
2
Tolerance
is
based
on
maximum
values
of
0.20
ppm
for
combined
residues.
Wheat,
grain
Wheat,
hay
2.0
1.41
Adequate
residue
data
are
available
reflecting
only
a
single
application
prior
to
harvest
of
Wheat,
hay.

Wheat,
straw
13
101
Adequate
residue
data
are
available.
Wheat,
straw
Tolerances
under
§
180.434(
c)

Cranberry
1.0
1.0
Adequate
residue
data
are
available.
Although
the
tolerance
spreadsheet
recommends
a
0.9
ppm
tolerance,
a
slightly
higher
1.0
ppm
tolerance
was
selected
to
harmonize
with
the
berries
crop
group.
Cranberry
Mint,
tops
(
leaves
and
stems)
0.3
Delete
Adequate
data
are
available
for
all
major
mint
growing
regions.
The
tolerance
under
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
58
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Table
9.
Tolerance
Summary
for
Propiconazole
Crop
Commodity
Proposed
or
(
Established)
Tolerance
(
ppm)
6
HED
Recommend
ed
Tolerance
(
ppm)
Comments
(
Correct
Commodity
Definition)
180.434(
c)
should
be
deleted
once
the
new
tolerance
on
mint
is
established
under
180.434(
a)
Tolerances
under
§
180.434(
d)

Alfalfa
0.1
0.1
2
Adequate
residue
data
are
available
to
support
a
75­
day
PBI
for
alfalfa.
Separate
tolerances
should
be
established
for
inadvertent
residues
in/
on
alfalfa,
forage
and
alfalfa,
hay,
each
at
0.1
ppm
1
Tolerance
level
was
calculated
using
the
tolerance
spreadsheet
and
the
relevant
Agency
guidance
(
see
Appendix
II).
2
Recommended
tolerance
is
based
on
maximum
residue
levels
due
to
the
large
portion
(>
15%)
of
samples
having
residues
<
LOQ.
3
The
residue
data
on
sweet
corn
were
reviewed
under
PP#
8F3674
(
C.
Deyrup,
12/
14/
88).
4
The
tolerance
spreadsheet
recommended
a
tolerance
of
16
ppm
for
rice
grain
assuming
that
the
data
are
distributed
lognormally.
However,
an
examination
of
the
plot
suggests
that
the
data
are
not
log
normal;
therefore,
a
tolerance
of
7
ppm
was
selected
using
the
California
Method
(
µ
+
3 ).
Combined
residues
in/
on
rice
grain
were
<
0.05­
5.20
ppm
and
averaged
1.49
ppm.
5
Additional
residue
data
are
required.
Therefore
only
a
conditional,
time­
limited
tolerance
is
being
recommended.
6
Tolerances
in
parenthesis
are
currently
established
under
40
CFR
§
180.434.
Propiconazole
Summary
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Barcode
D238458
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59
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63
References
DP
Barcode:
None
Subject:
PP#
4F3007.
CGA­
64250
(
Tilt)
in
Pecans.
Evaluation
of
Residue
Data
and
Analytical
Method.
From:
A.
Smith
To:
H.
Jacoby
Dated:
5/
15/
84
MRID(
s):
00074495,
00074508,
00074509,
and
00153327
RCB#:
4279
DP
Barcode:
None
Subject:
PP#
8F3674.
Propiconazole
in
or
on
Celery,
Corn,
Pineapple,
and
Legume
Vegetables.
Evaluation
of
the
Analytical
Methodology
and
Residue
Data.
From:
C.
Deyrup
To:
L.
Rossi
Dated:
12/
14/
88
MRID(
s):
40783301­
40783310
DEB#:
6724
DP
Barcode:
None
Subject:
PP#
0F3869:
Propiconazole
(
Tilt
®
)
in
or
on
Celery.
Amendment
of
3/
1/
90.
From:
W.
Chin
To:
S.
Lewis
Dated:
8/
15/
90
MRID(
s):
41486801
and
41486802
CB#:
7822
DP
Barcode:
1­
0964
Subject:
PP#
1F3974.
Propiconazole
on
Grass
Seed
Screenings,
Straw,
and
Forage.
Evaluation
of
Residue
Data
and
Analytical
Methodology.
From:
S.
Willett
To:
S.
Lewis
and
J.
Stone
Dated:
6/
11/
91
MRID(
s):
41823301­
41823305
DP
Barcode:
D219664
Subject:
PP#
5F04591,
Propiconazole
on
the
Berry
Crop
Grouping,
Carrots,
and
Onions
(
green
and
dry
bulb).
From:
L.
Kutney
To:
D.
McCall
Dated:
6/
14/
96
MRID(
s):
43786401­
43786404
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
60
of
63
DP
Barcode:
D209468
Subject:
PP#
2E04047.
Propiconazole
(
Tilt
®
Fungicide)
in
or
on
Mint.
Amendment
submitted
on
10/
24/
94.
From:
Y.
Donovan
To:
H.
Jamerson
and
J.
Smith
Dated:
4/
25/
95
MRID(
s):
43424601
DP
Barcodes:
D210266
and
D210295
Subject:
PP5F04424
&
ID#
000100­
00618
CGA­
64250
Technical:
Propiconazole
in/
on
Dry
Beans
and
Soybeans.
Evaluation
of
Reisdue
Data
and
Analytical
Methodology.
From:
M.
Rodriguez
To:
D.
McCall
and
S.
Robbins
Dated:
3/
5/
97
MRID(
s):
43386501
and
43386502
DP
Barcode:
D240856
Subject:
Propiconazole
(
122101):
Residue
Analytical
Method
(
GLN
860.1340),
Storage
Stability
Data
(
GLN
860.1380),
Magnitude
of
the
Residue
in
Rice
and
Wheat
(
GLN
860.1500),
and
Magnitude
of
the
Residue
in
Processed
Food/
Feed
Commodities
of
Wheat
(
GLN
860.1520)
From:
T.
Morton
To:
P.
Dobak/
S.
Lewis
Dated:
2/
23/
05
MRID(
s):
44411201­
44411208
DP
Barcode:
D246884
Subject:
Propiconazole
(
122101):
Petition
PP#
5F04424:
Magnitude
of
the
Residue
in/
on
Soybean
Aspirated
Grain
Fractions
(
GLN
860.1500).
From:
T.
Morton
To:
P.
Dobak/
S.
Lewis
Dated:
3/
10/
05
MRID(
s):
44549101
Propiconazole
Summary
of
Analyt
ical
Chemist
ry
and
Residue
Data
Barcode
D238458
Page
61
of
63
DP
Barcode:
D329394
Subject:
Propiconazole
(
122101):
Reregistration
Eligibility
Decision
(
RED)
Document;
Revised
Residue
Chemistry
Considerations.
From:
Y.
Donovan
To:
M.
Goodis
and
C.
Scheltema
Dated:
6/
15/
06
MRID(
s):
None
Attachments:
Appendix
I
­
International
Residue
Limits
Status
Appendix
II
­
Tolerance
Assessment
Calculations
Template
Version
September
2005
Propiconazole
Summary
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ical
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ry
and
Residue
Data
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D238458
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62
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63
Appendix
I
 
International
Residue
Limits
INTERNATIONAL
RESIDUE
LIMIT
STATUS
Chemical
Name:
1­[[
2­(
2,4­
dichlorophenyl)­
4­
propyl­
1,3­
dioxolan­
2­
yl]
methyl]­
1H­
1,2,4­
triazole
Common
Name:
Propiconazole
X
Proposed
tolerances
9
Reevaluated
tolerance
9
Other
Date:
7/
14/
06
Codex
Status
(
Maximum
Residue
Limits)
U.
S.
Tolerances
X
No
Codex
proposal
step
6
or
above
9
No
Codex
proposal
step
6
or
above
for
the
crops
requested
Petition
Number:
2F6371,
6E4788,
7E4860,
and
8E4931
DP
Barcode:
D238458
Other
Identifier:

Reviewer/
Branch:
Y.
Donovan/
RAB4
Residue
definition
(
step
8/
CXL):
Propiconazole
Residue
definition:
Tolerances
are
currently
expressed
as
the
combined
residues
of
propiconazole
and
its
metabolites
determined
as
2,4­
DCBA
and
expressed
as
parent.
However,
HED
has
recommended
that
the
tolerance
expression
be
changed
to
include
only
parent.

Crop
(
s)
1
MRL
(
mg/
kg)
Crop(
s)
Proposed
or
Established
Tolerance
(
ppm)

Almonds
0.05
Tree
nuts
0.10
Banana
0.1
Banana
0.2
Barley
0.05
Barley,
grain
0.3
Coffee
beans
0.1
Not
registered
use
Liver
and
Kidneys
of
cattle,
goats,
horses,
hogs,
and
sheep
2.0
Edible
offal
(
mammalian)
0.05
Meat
byproducts,
except
liver
and
kidney
0.1
Eggs
0.05
Tolerance
not
required
Grapes
0.5
No
registered
uses
Mango
0.05
No
registered
uses
Meat
(
from
mammals
other
than
marine
mammals)
0.05
Meat
and
fat
of
cattle,
goats,
horses,
hogs,
and
sheep
0.1
Milks
0.01
Tolerance
not
required
Oats
0.05
Oats,
grain
0.3
Peanut
0.05
Peanut,
whole
0.1
Peanut
0.2
Pecan
0.05
Tree
Nuts
0.10
Propiconazole
Summary
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D238458
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Poultry
meat
0.05
Tolerance
not
required
Rape
seed
0.05
No
registered
uses
Rye
0.05
Rye,
grain
0.3
Stone
fruits
1.0
Fruit,
Stone,
group
12
1.0
Sugar
beet
0.05
Beet,
sugar,
roots
Sugar
beet
leaves
or
tops
0.5
Beet,
sugar,
tops
10
Sugar
cane
0.05
No
registered
uses
Wheat
0.05
Wheat
Grain
0.3
Limits
for
Canada
Limits
for
Mexico
9
No
Limits
9
No
Limits
for
the
crops
requested
9
No
Limits
9
No
Limits
for
the
crops
requested
Residue
definition:
Propiconazole
and
its
metabolites
including
the
2,4­
DCBA
moiety
Residue
definition:
Propiconazole
Crop(
s)
MRL
(
mg/
kg)
Crop(
s)
MRL
(
ppm)
Liver
and
kidney
of
cattle
2
Barley
0.1
Apricots,
cherries,
peaches/
nectarines,
plums
1
Beans
0.5
Dried
blueberries
0.15
Walnut
0.1
Asparagus
0.1
Banana
0.2
Barley,
oats,
wheat
0.05
Wheat
0.1
Blueberries
0.02
blackberries,
loganberries
and
raspberries
0.7
proposed
Notes/
Special
Instructions: