cometadata/test-preprints-extracted-funding huggingface dataset:
This work was supported by the National Institutes of Health (NIH) Pathway to 363 Independence Award (K99/R00 5R00NS092996-03), the Brain Initiative award 364 (1RF1MH123247-01), and the NIH R01 award (1R01NS113889-01A1). This work was also 365 supported by the National Institute of Neurological Disorders and Stroke Parkinson's Disease 366 Biomarker Program (NS06722 and NS112008 to X.H), the National Institute of Aging 367 (AG067651 to G.B), the Hershey Medical Center General Clinical Research Center (National 368 Center for Research Resources, Grant UL1 RR033184 that is now at the National Center for 369 Advancing Translational Sciences, Grant UL1 TR000127), the PA Department of Health 370 Tobacco CURE Funds, and the Penn State Translational Brain Research Center. The authors 371 report no financial interests or potential conflicts of interest. 372
This study was supported by grants from National Institutes of Health (Bethesda, Maryland, USA) F32NR015728 (KES), KL2 TR003108 (KES), NS110598 (YG), NS117761 (YG), R01GM118760 (SDT), the Arkansas Children's Research Institute (KES), the Arkansas Breast Cancer Research Program (KES) as well as a seed grant from the Johns Hopkins Blaustein Pain Research Fund (SDT). We thank Rakel Tryggvadóttir and Dr. Jaclyn Daniels for their technical assistance. All authors report no conflicts of interest.
This work was supported by the projects SAF2016-80726-R and PID2019-104683RB-I00 of the Spanish Ministry of Economy and Competitiveness (AEI/FEDER, UE). C. Delgado-Sallent is a FI predoctoral fellow (2018 FI_B_00112) from the Generalitat de Catalunya (AGAUR). AB. Fath was supported by the Spain-USA Fulbright program. The authors declare no conflict of interest.
This work was supported, in whole or in part, by the Israel Science Foundation, founded by the Israel Academy of Science and Humanities (grant number 717/2017 to O.S.-F.), the USIsrael Binational Science Foundation 2015207 (to O.S.-F.), and the National Institutes of Health (grant R-R01-GM-040602 to C.A.F.). J.K.V. acknowledges support from CM-SMPKA107/426559/2019 and CM-SMP-SH/311264/2018 of the Tempus Mundi Foundation. K.D. and K.W.L acknowledge support from the Rackham Graduate School.
MESA and the MESA SHARe project are conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with MESA investigators. Support for MESA is provided by contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC95167, N01-HC-95168, N01-HC-95169, UL1-TR-000040, UL1-TR-001079, UL1-TR-001420, UL1-TR-001881, and DK063491. Funding for SHARe genotyping was provided by NHLBI Contract N02-HL-64278. Genotyping was performed at Affymetrix (Santa Clara, California, USA) and the Broad Institute of Harvard and MIT (Boston, Massachusetts, USA) using the Affymetrix Genome-Wide Human SNP Array 6.0. The MESA Epigenomics &amp; Transcriptomics Studies were funded by NIH grants R01HL101250, R01HL119962, R01DK101921, R01HL135009, and 1RF1AG054474. Funding support for the Neighborhood scales dataset was provided by grant HL071759-01.
This research was funded by the following awards from the National Institute on Aging (NIA): K99 AG056599, R00 AG056599, P30 AG012846, (Schmitz), and P30 AG017266 (Schmitz and Lu), and the National Heart, Lung and Blood Institute (NHLBI): R01 HL141292 (Smith). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
This work was supported by the Gordon and Betty Moore Foundation through award 5479, and by the Centre for Ocean Life, a VKR Centre for Excellence funded by the Villum Foundation. CSP was also funded by the Simons Foundation Postdoctoral Fellowship in Marine Microbial Ecology. B.A.W. was funded by a Royal Society University Research Fellowship. Data-sets for this research are included in these papers (and their supplementary information files): San Martin et al. (2006); Lopez and Anadon (2008); Saba et al. (2011); Le Moigne et al. (2013); S. Henson et al. (2019).
We thank members of the Trejo lab for advice and guidance. We also thank Dr. Antonio De Maio (UC San Diego) for assistance with Flow Cytometry and Cara R. Rada and Hilda Mejia-Peña assisting with HUVEC cell culture. This work was supported by NIH/NIGMS R01 GM116597 and R35 GM127121 (J.T.), NIH/NIGMS R25 GM083275 (M.C., L.J.C.), NIH/NHLBI T32 HL007444 (C.B.), NIH/NIGMS K12 GM068524 (O.M.I., D.N.), NIH/NICHD P50 HD12303 (M.A.L), and UC President's Postdoctoral Fellowship (O.M.I. and D.N.).
We would like the study participants. We also thank Brian Grimberg (Case Western Reserve University) for assistance with developing the multiplex qPCR assay and Erik Gaskin for review of the literature. This project was funded with support from the Indiana Clinical and Translational Sciences Institute funded, in part by Grant #'s UL1TR001108 and KL2TR001106 from the National Institutes of Health, National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
O.T.-S.). J.C.M.M. acknowledges support from an EMBO Long Term Fellowship. We thank Jan Huebner and Bayer for the gift of EpoB, Dirk Trauner for enabling the material transfers, Monique Preusse for early cell viability testing, and Rebekkah Hammar for performing the tubulin polymerisation assay. We are grateful to Henrietta Lacks, now deceased, and to her surviving family members for their contributions to biomedical research.
This research was supported by funds from the German Research Foundation (DFG: Emmy Noether grant number 400324123; SFB 1032 project B09 number 201269156; SFB TRR 152 project P24 number 239283807; and SPP 1926 project number 426018126 to
This work was supported by the National Institutes of Health (NIH), NIA grant number R01AG058822 to JPH. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This research was also supported in part by the Department of Veterans Affairs by the Translational Research Center for TBI and Stress Disorders (TRACTS), a VA Rehabilitation Research and Development Traumatic Brain Injury Center of Excellence (B9254-C). The authors declare no conflict of interest.
This research was supported by a European Research Council Advanced Grant. I.C. acknowledges funding by the University of Oxford, the EPSRC &amp; BBSRC Centre for Doctoral Training in Synthetic Biology (grant EP/L016494/1), the Clarendon Fund Scholarship, and the Oxford-Broomhead Graduate Scholarship. M.J.B. acknowledges funding by a Royal Society University Research Fellowship. The authors thank Dr Alessandro Alcinesio for insightful discussions, contact angle analyses and assistance with fluorescence microscopy.
Acknowledgement : The authors acknowledge the facilities and the scientific and technical assistance of the National Imaging Facility at the Centre for Advanced Imaging, University of Queensland, Ms Wendy Strugnell FSMRT, the electrophysiology scientists of The Prince Charles Hospital, and funding from the UQ Academic Title Holders grant.
Funding : This work was supported by UQ Academic Title Holder Research Fund and CAESIE: Connecting Australian European Science &amp; Innovation Excellence Priming Grant .
This project received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement 647687). We thank the ARPEGE platform at the Institut de Génomique Fonctionnelle for providing facilities and technical support. C.A is grateful for the funding by the Deutsche Forschungsgemeinschaft DFG Grant No. AR 376/18-1. Mass spectrometry experiments were carried out using the facilities of the Montpellier Proteomics Platform (PPM, BioCampus Montpellier). This work was supported by the regional funds FEDER/Région Occitanie. This work was publicly funded through ANR (the French National Research Agency) under the "Investissements d'avenir" programme with the reference ANR-16-IDEX-0006» (University of Montpellier Isite-MUSE).
I.V.G. is supported by a fellowship from the Ovarian Cancer Research Alliance. S.P.S.
acknowledgessupportfromtheMSKCancerCenterSupportGrant/CoreGrant(P30 CA008748). N.A.W.acknowledgessupportfromtheUKSpaceAgency(ST/R004838/1) andtheScienceandTechnologiesFacilityCouncil-UKResearchandInnovation(ST/T003081/1). This work was supported by Cancer Research UK [A24042, A21143]. G.J.H. is a Royal Society Wolfson Research Professor.
This work was supported by the Simpson Querrey Center for Neurogenetics (to D.K.)
We would like to thank all of the subjects who donated their time and biological samples to be a part of this study. We also would like to thank all members of the International Parkinson's Disease Genomics Consortium (IPDGC). For a complete overview of members, acknowledgements and funding, please see http://pdgenetics.org/partners. This work was supported in part by the Intramural Research Programs of the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Aging (NIA), and the National Institute of Environmental Health Sciences both part of the National Institutes of Health, Department of Health and Human Services; project numbers 1ZIA-NS003154, Z01-AG000949-02
and Z01-ES101986. In addition, this work was supported by the Department of Defense (award W81XWH-09-2-0128), and The Michael J Fox Foundation for Parkinson's Research. This work utilized the computational resources of the NIH HPC Biowulf cluster (http://hpc.nih.gov). The access to part of the participants for this research has been made possible thanks to the Quebec Parkinson's Network (http://rpq-qpn.ca/en/).
This work was supported by the Bill &amp; Melinda Gates Foundation (OPP1148627). The computations in this paper were run on the FASRC Cannon cluster supported by the FAS Division of Science Research Computing Group at Harvard University. We thank Giovanni Traverso, Ameya Kirtane, Morgan Craig, Martin Nowak, Katharine Best, Madison Ski Krieger, Michael Desai, and John Wakeley for helpful feedback on this project.
This work was funded by Agence Nationale de la Recherche (ANR-17-CE16-0027 and ANR-20-CE16693 0026 to JB and ANR-15-CE16-0013 to GF) and CNRS, Université Paris-Saclay and NeuroPSI. CH held a doctoral 694 fellowship from Région Ile-de-France and a fellowship extension from Fondation pour la Recherche Médicale 695 (contract # FDT201904007982). We thank Aurélie Heuzé for lab management and genotyping animals, Edwin 696 Gatier for help with DeepLabCut and analytic scripts, Jean-François Brunet for providing the 697 Atoh1 FRTCre ;Phox2b Flpo animals, and the animal facility for housing animals. 698
This research was supported by the Japan Agency for Medical Research and Development through its research grant 'Core Center for iPS Cell Research, Research Center Network for Realization of Regenerative Medicine'. This research was supported in part by the grants from a JSPS KAKENHI Grant-in-Aid for Young Scientists (A) (17H05063) to Y.H., Grant-in-Aid for Early-Career Scientists (18K15054) to G.T., Grantin-Aid for Scientific Research (B) (20H03442) to Y.M., Grant-in-Aid for Challenging Research (Pioneering) (20K21409) to Y.M., Grants for iPS cell research from AMED (12103610 and 17935400) to M.K.S., Interstellar Initiative from AMED (20jm0610032h0001) to Y.M., Takeda Science Foundation to Y.H. and Y.M., Uehara Memorial Foundation to Y.H., The Tokyo Biochemical Research Foundation to Y.H. and Y.M., Sumitomo Foundation Grant For Basic Science Research Projects to Y.M., Ichiro Kanehara Foundation Grant to Y.M., and Naito Foundation Research Grant to Y.M.
We thank Anika Boettcher, Ralph Boettcher and Mara Catani for the helpful comments and discussion. We thank Michael Sterr, Bianca Vogel, Anne Savoca, Maximilian Schuster, Mahfuza Akter, Johanna Tüshaus, Kerstin Diemer, Robert Fimmen and Ines Kunze for technical support. The work was supported by the Helmholtz Society, Helmholtz Portfolio Theme 'Metabolic Dysfunction and Common Disease, German Research Foundation, and German Center for Diabetes Research (DZD e.V.) for financial support. This project was supported by DZD, DZD-Next funding (M.B., Ü.C. and H.L.) and the Tistou &amp; Charlotte Kerstan Stiftung (M.U. and K.B.).
This work was supported by the National Science Foundation through the Center for Engineering MechanoBiology STC (CMMI: 15-48571) and the UPenn MRSEC program (DMR-1720530), as well as through the National Institutes of Health (R01AR077362 to J.A.B.) and the German Science Foundation (QA 58/1-1 to T.H.Q.). The authors thank the Cell and Developmental Biology (CDB) Microscopy Core at the University of Pennsylvania for use of IMARIS software. The NSF Major Research Instrumentation Program (award NSF CHE1827457) and Vagelos Institute for Energy Science and Technology supported the purchase of the NMR machines used in this study. Schematics were created with Biorender.com.
Acknowledgments: The authors are grateful for funding support from Retina UK (GR595, GR584), MRC UK (MR/T017503/1), Fight for Sight (1456/1457) and ERC (CoG_614620). We would like to thank Newcastle University Bioimaging facility for help with imaging assays. Acknowledgment is made to Bio Render (www.biorender.com). Figure 7 was created with BioRender.com.
We thank members of the Chu lab for technical support and helpful discussions. We thank the Flow Cytometry Core Facility at the La Jolla Institute and Cheryl Kim for their expertise and instrument support. This work was supported by R00 DK110534 and P30 DK120515 from the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) and the Chiba University-UC San Diego Center for Mucosal Immunology, Allergy and Vaccines (cMAV) to H.C. Additional support was provided to H.C. by CIFAR Humans and the Microbiome Program and The Hartwell Foundation. M.C.T was supported by T32 DK007202 (NIDDK), the National Academies of Sciences, Engineering and Medicine through the Predoctoral Fellowship of the Ford Foundation, and the Howard Hughes Medical Institute (HHMI) Graduate Fellowships grant (GT15123).
- This work is supported by the National Institutes of Health under award numbers R01HL143468 338 and R21/R33HD090671. 339 - The authors acknowledge the supercomputing resources at the University of Maryland 340 (http://hpcc.umd.edu) and the Maryland Advanced Research Computing Center (MARCC) 341 - (https://www.marcc.jhu.edu) that made available for conducting the research reported in this paper. 342
The authors would like to thank the AZ UKCCB team for the provision of the cell line. JCZ is funded by the UKRI-BBSRC DTP (UK Research and Innovation and the Biotechnology and Biological Science Research Council Doctoral Training Partnership) studentship and AstraZeneca. CBS acknowledges support from the Philip Leverhulme Prize, the Royal Society Wolfson Fellowship, the EPSRC grants EP/S026045/1 and EP/T003553/1, EP/N014588/1, EP/T017961/1, the Wellcome Innovator Award RG98755, the Leverhulme Trust project Unveiling the invisible, the European Union Horizon 2020 research and innovation programme under the Marie Skodowska-Curie grant agreement No. 777826 NoMADS, the Cantab Capital Institute for the Mathematics of Information and the Alan Turing Institute. Authors EM, GW, RT, YW are employees of AstraZeneca. AstraZeneca provided the funding for this research and provided support in the form of salaries for the authors, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Z.C., X.F. and L.X. acknowledge the support from Natural Science Foundation of China (NSFC No. 61988101, 62073137). X.F. acknowledge the support from Shanghai Sailing Program (22YF1410700). T.L.L was supported by the Netherlands Organization for Scientific Research (NWO, gravitation program CancerGenomiCs.nl), Oncode Institute, which is partly financed by the Dutch Cancer Society, and the European Research Council (ERC Starting Grant 755695 BURSTREG). R.G was supported by a Leverhulme Trust research award (RPG-2020-327).
R.G.-B. received research support from Gilead. S.A.J. and A.H. are employees of Pfizer, Inc. H.M.L. received research grants from Abbvie, Pfizer, Novartis, Sobi, Roche/Chugai, Gilead, Galapagos, GSK, UCB, MSD, and BMS. P.A.N. has received investigator-initiated research grants from AbbVie, BMS, Novartis, Pfizer and Sobi; consulting fees from BMS, Cerecor, Miach Orthopedics, Novartis, Pfizer, Quench Bio, Sigilon, Simcere, Sobi, XBiotech, and Exo
Therapeutics; royalties from UpToDate Inc. and the American Academy of Pediatrics; and salary support from the Childhood Arthritis and Rheumatology Research Alliance.
This work was supported by funds from the state of Baden-Wuerttemberg within the Centers for Personalized Medicine Baden-Wuerttemberg (ZPM), an MD fellowship from Boehringer Ingelheim Fonds, a physician-scientist development grant from the Medical Faculty Heidelberg, and a research grant from the German Society for Rheumatology (DGRh), and a Gilead grant (to R.G-B.). T.E. was funded by the MD/PhD Programme of Heidelberg Faculty of Medicine. F.A.R. was supported by an MD fellowship from Boehringer Ingelheim Fonds. P.A.N is supported by NIH/NIAMS awards 2R01AR065538, R01AR075906, R01AR073201, R21AR076630, 2P30AR070253, R56AR065538, NIH/NHLBI R21HL150575, the Fundación Bechara, the Samara Jan Turkel Center for Pediatric Autoimmune Diseases at Boston Children's Hospital, and the Arbuckle Family Fund for Arthritis Research. Some data reported were collected with the support of an investigator-initiated research grant to P.A.N. from Pfizer, Inc., but final decision about data analysis and publication remained with P.A.N.
The authors would like to thank Dr. Richard Janissen (TU Delft, Netherlands) for fruitful discussions. The authors are greatly indebted to Ursula F.S. Roggero (FEEC, UNICAMP) and Vitor Pelegati (IFGW, UNICAMP) for their assistance during sample preparation and confocal microscope access, respectively. This work was financially supported by the Brazilian agencies CNPq (441799/2016-7 and 429326/2018-1) and FAPESP (Grants number 2013/10957-0 and 2019/07616-3). S.A. and A.M.S acknowledge FAPESP (2017/14398-7) and CNPq, respectively, for funding their scholarships. The authors thank INFABIC/UNICAMP (FAPESP: 2014/50938-8, CNPq: 465699/2014-6), Semiconductor Component and Nanotechnology Center (CCSNano, UNICAMP) and the Device Research Laboratory (IFGW, UNICAMP) for granting access to their facilities.
- The authors would like to thank Francesco Delogu and Benoit Kunath, for scientific discussions. Development and data analysis were performed using the research cluster of the Faculty of Science at the University of Amsterdam and the HPC facilities of the University of Luxembourg, both of whose administrators are thanked for excellent support. We also thank Adrian Fritz of the CAMI team for support.
- This work was supported by the Luxembourg National Research Fund (FNR) under grant PRIDE/11823097 477 - and the European Research Council (ERC-CoG 863664). 478
We would like to generously thank Gerry Wright for access to the Wright Actinomycete 507 Collection, as well as Matt Hutchings and Thomas Mclean for helpful discussions. This work has 508 been supported by a Natural Sciences and Engineering Research Council (NSERC) Discovery 509 grant for MAE, a DFG Fellowship to TN (NE-2384/1-1), and an Ontario Graduate Scholarship and 510 NSERC CGS-D doctoral scholarship to EMFS. 511
Acknowledgements: We thank Dr. Sophie Z. Gu for detailed edits of the manuscript. We thank Prof. Geraldine Seydoux for access to the Lonza 4D nucleofector system. We thank the Johns Hopkins Transcriptomics and Deep Sequencing Core for Illumina sequencing. Funding: This work was supported by the grants from the National Institutes of Health (R35 GM 122569 and U01 DK 127432 to T.H.; T32 GM 136577 and F30 CA 254160 to R.S.Z., available under aCC-BY 4.0 International license. (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made bioRxiv preprint doi: https://doi.org/10.1101/2022.01.18.476836; this version posted January 20, 2022. The copyright holder for this preprint
We thank Samer Girgis and Trista Lou for technical assistance. This work was supported by grants from the Canadian Institutes of Health Research (CIHR; FDN-148423) to N.S. and the Terry Fox Research Institute (1073) to N.S. and T.A., and the Biotechnology and Biological Sciences Research Council (BB/W008165/1) to S.M.J. X.Z. is supported by funding from the China Scholarship Council (CSC). J.H.C is supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (2020R1A6A3A03040141). S.M.J. is supported by the Patrick Johnston Research Fellowship, Queen's University, Belfast. The graphical abstract was generated with BioRender.com.
Acknowledgements: S.B. was supported by NIH/NIBIB Grant Number R01EB024591 (PI: D.D.V.), in part by NSF Collaborative Research grant MCB-2027949 (PI: D.D.V.) and by the DoD Newton Award for Transformative Ideas during the COVID-19 Pandemic. R.J.W. was supported in part by NSF Collaborative Research grant MCB-2027947 (PI: R.J.W.) and by the Charles Lee Powell Foundation. R.J.W. also gratefully acknowledges the hospitality of the Center of Mathematical Sciences and Applications at Harvard University for her sabbatical visit, during which preliminary discussions were conducted with S.B. and D.D.V. on the research reported here.
Editing and Animal Model Core for their assistance generating PCK2 f/f mice, and Jiwon Seo and Jody Peter at the UW-Madison Biomedical Research Model Services Breeding Core for their assistance with animal husbandry and genotyping. Graphics were created using BioRender.com. The Merrins laboratory gratefully acknowledges support from the NIH/NIDDK (R01DK113103 and R01DK113103) and the Department of Veterans Affairs (I01B005113). HRF received a postdoctoral fellowships from HRSA (T32HP10010) and the NIH/NIA (T32AG000213), SLL received a predoctoral fellowship from the NIH/NIDDK (T32DK007665), HRV received a postdoctoral fellowship from the American Diabetes Association (1-17-PDF-155), and we acknowledge Dudley Lamming for contributing support for EP from R01AG062328. The Kibbey laboratory gratefully acknowledges support from the NIH/NIDDK (R01DK127637). This work utilized facilities and resources from the William S. Middleton Memorial Veterans Hospital and does not represent the views of the Department of Veterans Affairs or the United States Government.
Dr. Butt has received institutional grant funding from Gilead Sciences unrelated to the work presented in this paper. Otherwise, we declare no competing interests.
We acknowledge the many dedicated individuals at Hamad Medical Corporation, the Ministry of Public Health, the Primary Health Care Corporation, Qatar Biobank, Sidra Medicine, and Weill Cornell Medicine-Qatar for their diligent efforts and contributions to make this study possible. The authors are grateful for institutional salary support from the Biomedical Research Program and the Biostatistics, Epidemiology, and Biomathematics Research Core, both at Weill Cornell Medicine-Qatar, as well as for institutional salary support provided by the Ministry of Public Health, Hamad Medical Corporation, and Sidra Medicine. The authors are also grateful for the Qatar Genome Programme and Qatar University Biomedical Research Center for institutional support for the reagents needed for the viral genome sequencing. The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the article. Statements made herein are solely the responsibility of the authors.