DOI: 10.1101/2023.05.04.539504
Funding statement: J.D.H. acknowledges the support of the National Science Foundation. N.S.G. acknowledges financial support from the Foundation for Food and Agriculture Research (FFAR) Fellows program. We acknowledge support of the IGI LGR ERA, GlaxoSmithKline, and Citris/Banatao Seed Funding. We acknowledge support of a Burroughs Wellcome Fund Career Award at the Scientific Interface (CASI) (to M.P.L.), a Dreyfus foundation award (to M.P.L.), an NIH MIRA award (to M.P.L.), an NSF CAREER award (to M.P.L), an NSF CGEM award (to M.P.L.), a FFAR Young Investigator award (to M.P.L.), a CZI investigator award (to M.P.L), a Sloan Foundation Award (to M.P.L.), a and Moore Foundation Award (to M.P.L.). M.P.L. is a Chan Zuckerberg Biohub investigator, a Hellen Wills Neuroscience Institute Investigator, and an IGI Investigator. R.L.P. acknowledges support from the Schmidt Science Fellows program, in partnership with the Rhodes Trust. Efforts to apply XSI for studying ssDNA on SWCNTs are supported in part by National Cancer Institute grants Structural Biology of DNA Repair (SBDR) CA092584 and CA220430. XSI data was collected at the Advanced Light Source (ALS) beamline SIBYLS which is supported by the DOE-BER IDAT DE-AC02-05CH11231 and NIGMS ALS-ENABLE (P30 GM124169 and S10OD018483). This work benefited from the use of the SasView application, originally developed under NSF award DMR- 0520547. SasView contains code developed with funding from the European Union's | Horizon 2020 research and innovation program under the SINE2020 project, grant agreement No 654000. We thank the staff at the University of California, Berkeley Electron Microscope Laboratory for advice and assistance in electron microscopy sample preparation and data collection. Additional electron microscopy was conducted at the National Center for Electron Microscopy at the Molecular Foundry, Lawrence Berkeley National Laboratory. Work at the Molecular Foundry was supported by the Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. Molecular graphics and analyses performed with UCSF Chimera, developed by the Resource for Biocomputing, Visualization, and Informatics at the University of California, San Francisco, with support from NIH P41GM103311. We would like to acknowledge the use of medical clipart from BioRender.com. Thank you to Dr. Daniel Murray, Dr. Lee Joon Kim, Dr. Abraham Beyene, Dr. James Holton, Dr. Andrew Crothers, and Dr. Michal Hammel for their helpful feedback and editing of this manuscript. Thank you to Brandon Russel for enabling remote modeling operations. Thank you to Elizabeth Voke for making this long-distance project possible by always being ready to send images of written lab notebooks during the manuscript writing process.
Annotated funders:
funder_name: National Science Foundation
awards: award_ids: DMR- 0520547
funder_name: Foundation for Food and Agriculture Research (FFAR)
funder_name: IGI
awards: award_title: LGR
ERA
funder_name: GlaxoSmithKline
funder_name: Citris/Banatao
awards: award_title: Seed Funding
funder_name: Burroughs Wellcome Fund
awards: award_title: Career Award
funder_name: Dreyfus foundation
awards: award_title: Dreyfus foundation Award
funder_name: NIH
awards: award_ids: P41GM103311
award_title: MIRA award
funder_name: NSF
awards: award_title: CAREER award
award_title: CGEM award
funder_name: FFAR
awards: award_title: Young Investigator award
funder_name: CZI
awards: award_title: Investigator award
funder_name: Sloan Foundation
awards: award_title: Sloan Foundation Award
funder_name: Moore Foundation
awards: award_title: Moore Foundation Award
funder_name: Schmidt Science
awards: award_title: Fellows program
funder_name: Rhodes Trust
funder_name: National Cancer Institute
awards: award_ids: CA092584
CA220430
award_title: Structural Biology of DNA Repair
funder_name: DOE-BER
awards: award_ids: IDAT DE-AC02-05CH11231
award_title: SasView application
funder_name: NIGMS
awards: award_ids: P30 GM124169
S10OD018483
award_title: ALS-ENABLE
funder_name: European Union
awards: funding_scheme: Horizon 2020 research and innovation program
award_ids: 654000
award_title: SINE2020 project
funder_name: Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy
awards: award_ids: DE-AC02-05CH11231