cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2 of Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairments
Creators: name: Reverchon, Flora
name: Vidian De Concini
name: Larrigaldie, Vanessa
name: Benmerzoug, Sulayman
name: Briault, Sylvain
name: Dieudonnée Togbé
name: Ryffel, Bernhard
name: Quesniaux, Valérie F. J.
name: Menuet, Arnaud
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 2. Expression of IL-1a mRNA in hippocampi at 24 h and 48 h post-surgery, in Sham, vehicle or IL-33 intra-hippocampal treated mice with or without minocycline pretreatment. mRNA expression of the pro-inflammatory marker IL-1a was quantified in hippocampi by RT-qPCR normalized against 18S RNA. Relative fold change in vehicle group (grey bar) and in IL-33 group (black bar) were quantified versus sham group (S ; white bar). Minocycline treated mice were also analyzed at 48 h post-surgery (dotted bar). IL-33 injection delayed the resolution of inflammation highlighted by an increase of this markers at 48 h administration. A partial reduction of this effect was observed under minocycline exposure. Data are represented as mean ± SEM (n = 4-6). Statistical comparisons were made using Kruskal-Wallis followed by Dunn’s multiple comparison test for each group vs. Sham.**p ≤ 0.01, ***p ≤ 0.001. In addition, comparison between rmIL-33 (48 h) and rmIL-33 + mino (48 h) groups was performed using the Mann-Whithney test.
Additional file 1 of Piezo-tolerant natural gas-producing microbes under accumulating pCO2
Creators: name: Lindeboom, Ralph E. F.
name: Shin, Seung Gu
name: Weijma, Jan
name: Lier, Jules B. Van
name: Plugge, Caroline M.
Publisher: name: figshare
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Overview of used values for enthalpy of formation (ΔH f o ) and free energy of formation (ΔG f o ) [31].
Supplementary document for Local Models for Scatter Estimation and Descattering in Polyenergetic X-Ray Tomography - 5399630.pdf
Creators: name: McCann, Michael
name: Klasky, Marc
name: Schei, Jennifer
name: Ravishankar, Saiprasad
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplement 1
Addressing the transition needs of coursework post-graduate students
Creators: name: Lang, Catherine
Publisher: name: Swinburne
Year: 2024

description: This paper discusses the implementation of a transition program for Graduate Diploma students in the Information Technology (IT) discipline. These students were experiencing their first year of higher education in several years, or their first year in higher education in a new country. The program was implemented to cater for a mid-year intake of full-time on-campus students consisting mainly of international students, and a smaller number of part-time local students (a total cohort of 50). This prototype program was closely based on an undergraduate transition program instituted at a neighbouring university. The outcome of implementing a program devised for undergraduates on postgraduates has led to the conclusion that mature students require a different type of transition program. Their need for weekly study groups declines as the semester progresses due to their greater ability to network within their classes and lectures. Interestingly the establishment of an electronic forum was not widely used by these IT students.
« Je joue, donc je suis » : une étude de l’impact des jeux vidéo sur l’identité de joueurs franco-ontariens
Creators: name: Legault-Thivierge, Geoffroy
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: apprentissage
acculturation
sondage
entrevue
Franco-ontariens

description: Le jeu vidéo, de par sa popularité impressionnante et relativement récente, nécessite que l’on s’attarde à une analyse de ses impacts potentiels sur ses adeptes. Média largement prédominé par l’anglais, son impact sur l’identité de Franco-ontariens se révèle particulièrement pertinent étant donné la situation linguistique minoritaire de ces joueurs. Cette identité, bien qu’en harmonie avec les jeux vidéo, pourrait-elle entrer en conflit avec la langue de ces mêmes jeux? Dans cette étude, on cherche à étudier l’impact des jeux vidéo (considérés ici comme supports d’apprentissage à l’anglais) sous la forme d’apprentissage de la langue et d’acculturation (c.-à-d. l’ouverture d’esprit face à une autre culture et le délaissement de l’identité francophone). S’inscrivant dans un cadre théorique de sociologie des usages, cette étude s’attarde aux pratiques actuelles de 33 joueurs franco-ontariens, soit les activités et comportements des joueurs, par l’entremise d’un sondage (méthode quantitative) et d’entrevues semi-dirigées (méthode qualitative). Les résultats de la présente thèse suggèrent un impact des jeux vidéo, tant sur l’apprentissage de l’anglais des joueurs franco-ontariens, que sur leur identité. La maîtrise de vocabulaire, termes et expressions, etc. de la langue anglaise et la création d’une identité bilingue chez ces joueurs, résultants d’habitudes de consommation et de communication majoritairement anglophones, soulèvent un questionnement quant à l’avenir de l’identité francophone de ces joueurs.
Additional file 3 of Piezo-tolerant natural gas-producing microbes under accumulating pCO2
Creators: name: Lindeboom, Ralph E. F.
name: Shin, Seung Gu
name: Weijma, Jan
name: Lier, Jules B. Van
name: Plugge, Caroline M.
Publisher: name: figshare
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 3: Figure S1. Results of fed-batch reactor operation. Figure S2. Results of fed-batch reactor operation during experiment II. Figure S3. Archaeal DGGE profiles of the 16S rRNA gene fragments. Figure S4. Bacterial DGGE profiles of the 16S rRNA gene fragments. Figure S5. Results of propionate degradation during experiment IV.
Proposal for environmental mixture risk assessment in the context of the biocidal product authorization in the EU
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2013
Subjects: Mischungstoxizität
Bewertung

description: Background
The EU Council and Parliament recently agreed on a new regulation that will implement a new EU-wide, harmonized system for the authorization for biocidal products. Such products are in most cases multi-component mixtures of one or more active substances plus a range of co-formulants that serve different purposes, e.g. as stabilizers or preservatives. They are only allowed on the European market if their intended use does not lead to unacceptable risks for the environment. Consequently, the assessment of possible combination effects is a critically important step during the regulatory environmental risk assessment of biocidal products. However, no specific guidance is at hand on how combination effects should be accounted for during the regulatory environmental risk assessment of biocidal products.
Results and Conclusions
A tiered approach was developed that accommodates different data situations, optimizes resource usage, limits biotesting as far as possible and ensures adequate protection of the environment. It mainly builds on using Concentration Addition as a component-based approach for mixture toxicity prediction, complemented by whole product tests where appropriate. Concentration Addition is either approximated by summing up PEC/PNEC ratios or as sums of toxic units. The competing concept of Independent Action was assessed as not being suitable for incorporation into a tiered approach without explicit confirmatory studies, as it might otherwise lead to an underestimation of the actual environmental risk.
Quelle: http://link.springer.com/
Comparison of Ankle Kinematics between Soft and Semi-Rigid Ankle Orthoses for Field-Sport Activities
Creators: name: Becker, Shannon
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: ASO
Malleoloc
ankle kinematics
field-sport activities

description: Purpose of study: Examine ASO (soft) and Malleoloc semi-rigid stirrup (SRS) ankle orthosis designs on ankle kinematics during field-sport movements: sprint, one-legged jump, and 45-degree cut. Participants: 13 competitive Ultimate players who regularly wore an ankle orthosis during physical activity. Methods: ASO or Malleoloc orthosis was randomly assigned to each person. Kinematic data were captured while the participants performed several trials for each movement in a motion analysis laboratory. Participants repeated the protocol with the other orthosis. Results: ASO allowed significantly more plantar-flexion during weight acceptance of the planting foot in cutting (p=0.038). In jumping, the Malleoloc allowed significantly more eversion-inversion range during stance (p=0.048) and eversion-inversion angular velocity from midstance to toe-off (p=0.026). Qualitative data also showed a significant preference for ASO. Conclusion: Hypotheses that ankle inversion and eversion would be greater with the ASO; and plantar-flexion and dorsiflexion would be greater with the Malleoloc were refuted.
title: Comparison of methods to measure methane for use in genetic evaluation of dairy cattle
title: Comparison of methods to measure methane for use in genetic evaluation of dairy cattle
titleType: AlternativeTitle
Creators: name: Garnsworthy, Philip C.
name: Difford, Gareth F.
name: Bell, Matthew J.
name: Sorg, Diana
Publisher: name: My University
Year: 2019
Subjects: Methan
Umwelt

description: Partners in Expert Working Group WG2 of the COST Action METHAGENE have used several methods for measuring methane output by individual dairy cattle under various environmental conditions. Methods included respiration chambers, the sulphur hexafluoride (SF6) tracer technique, breath sampling during milking or feeding, the GreenFeed system, and the laser methane detector. The aim of the current study was to review and compare the suitability of methods for large-scale measurements of methane output by individual animals, which may be combined with other databases for genetic evaluations. Accuracy, precision and correlation between methods were assessed. Accuracy and precision are important, but data from different sources can be weighted or adjusted when combined if they are suitably correlated with the "true" value. All methods showed high correlations with respiration chambers. Comparisons among alternative methods generally had lower correlations than comparisons with respiration chambers, despite higher numbers of animals and in most cases simultaneous repeated measures per cow per method. Lower correlations could be due to increased variability and imprecision of alternative methods, or maybe different aspects of methane emission are captured using different methods. Results confirm that there is sufficient correlation between methods for measurements from all methods to be combined for international genetic studies and provide a much-needed framework for comparing genetic correlations between methods should these become available. Quelle: Verlagsinformation
Challenges in evaluating SARS-CoV-2 vaccines during the pandemic
Creators: name: Abu-Raya, Bahaa
name: Gantt, Soren
name: Sadarangani, Manish
Publisher: name: Canadian Medical Association Journal
Year: 2020

description: Key points: - Challenges to the evaluation of SARS-CoV-2 candidate vaccines prior to approval or licensure during the ongoing pandemic include rapidly changing levels of exposure to the virus and population immunity, social distancing practices, and the possibility of antibody-dependent enhancement of disease. - In order to measure vaccine efficacy accurately, researchers should account for these factors in sample size calculations and also carefully consider selection of trial endpoints. - SARS-CoV-2 vaccines must also be evaluated in populations known to be at increased risk for severe COVID-19, such as older adults, people of African descent, and people with multiple comorbidities. - Given the speed of SARS-CoV-2 vaccine development careful attention must be paid to post-licensure assessment of vaccines, including the risk of antibody dependent enhancement of disease, which must be actively monitored closely over multiple years after vaccination.
Ore Petrology and Alteration of the West Ansil Volcanic-hosted Massive Sulphide Deposit of the Noranda Mining Camp, Rouyn-Noranda, Quebec
Creators: name: Boucher, Stéphanie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: VMS deposit
Noranda Mining Camp
Cu-Zn Archean Deposit
West Ansil
Ansil
Rusty Ridge Formation

description: The West Ansil deposit was the first Cu discovery in 25 years in the Noranda Central Camp. It has a combined indicated and inferred resource of ~1.2 Mt. Grades for the indicated resource are 3.4% Cu, 0.4% Zn, 1.4 g/t Au and 9.2 g/t Ag. The bulk of the resource is located in three massive sulphide lenses (Upper, Middle and Lower) that are entirely within the Rusty Ridge Formation above the Lewis exhalite. The mineralization in all three ore lenses consists of massive pyrrhotite + chalcopyrite + magnetite. Semi-massive sphalerite is restricted to the upper and lower parts of the Middle lens. Massive magnetite occurs at the center of the Upper and Middle lenses, where it replaces massive pyrrhotite. A striking feature of West Ansil is the presence of abundant colloform and nodular pyrite (+marcasite) in the massive sulphides. Late-stage replacement of massive pyrrhotite by colloform pyrite and marcasite, occurs mostly along the upper and lower contacts of the lenses.
Supplementary information from Selective and prolonged attention to emotional scenes in humans and bonobos
Creators: name: van Berlo, Evy
name: Roth, Tom
name: Kim, Yena
name: Kret, Mariska Esther
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 320999
subject: Neurosciences not elsewhere classified

description: This file contains supplementary information on the methods, used stimuli, and analyses
The Role of the ISWI Proteins SNF2H and SNF2L in Ovarian Folliculogenesis
Creators: name: Pépin, David
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: fulliculogenesis
endocrinology
chromatin remodeling
ISWI

description: Folliculogenesis is a complex process which describes the maturation of the ovarian follicle, from the primordial stage all the way to the ovulation of the antral follicle, and its sequela, the formation of the corpus luteum (CL). Imitation switch (ISWI) proteins are a class of ATP-dependent chromatin remodelers which mobilize nucleosomes to regulate a number of cellular processes including transcription, replication, and DNA repair. The pattern of expression of the mammalian ISWI proteins SNF2H and SNF2L in the mouse ovary suggests a role in the coordination of the proliferation and differentiation of granulosa cells during folliculogenesis. Here, we report that SNF2H is associated with proliferating granulosa cells, while SNF2L expression is induced following the LH surge which triggers their terminal differentiation into luteal cells. Knockdown of Snf2l by siRNA is sufficient to downregulate the expression of StAR, an important steroidogenic enzyme, and marker of the CL. Furthermore, SNF2L is thought to directly regulate StAR expression by physically binding to its promoter as indicated by chromatin immunoprecipitation (ChIP). In order to identify additional targets regulated by SNF2L, an unbiased microarray screen was developed to look for genes induced by LH in a SNF2L-dependent manner. One of the candidates, Fgl2 is strongly induced at 8h post hCG only in granulosa cells with intact SNF2L activity. Furthermore overexpression of SNF2L is sufficient to induce FGL2, and SNF2L is present on its promoter in the SIGC rat granulosa cell line. Some of the SNF2L binding partners that may be important in this regulation are PR-A and FLI-I, which have been found to interact with SNF2L by IP. Finally we describe here the phenotype of a Snf2l KO mouse which includes multiple reproductive defects, including resistance to superovulation, low secondary follicle counts, and a high incidence of abnormal antral follicles. Taken together these data suggest an important role of ISWI proteins in folliculogenesis, particularly SNF2L, which may regulate multiple genes important for the terminal differentiation of granulosa cells into luteal cells following the LH surge.
An Examination of How a Coach of Disability Sport Learns to Coach from and Through Experience
Creators: name: Duarte, Tiago
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: lifelong learning
reflection
life-story
adaptive sailing

description: Despite the steady growth of coaching science over the last two decades, research on coaches of persons with disabilities is scarce. This study examined how an adaptive sailing coach learned through and from experience using a single case study methodology. Jarvis’s (2009) lifelong learning approach and Gilbert and Trudel’s (2001) reflective conversation model framed the thematic analysis. The findings revealed that the coach, Jenny, was exposed to collaborative environments that optimized her learning process. Social interactions with a number of people (e.g., mentors, colleagues, and athletes) possessing different types of expertise made major contributions to Jenny becoming a coach. As time progressed and Jenny was exposed to a mixture of challenges and learning situations, she advanced from recreational Para-swimming instructor to developmental adaptive sailing coach. This study informs future research in disability sport coaching.
Multi assessment approach to major projects
Creators: name: Blicblau, Aaron
Publisher: name: Swinburne
Year: 2024

description: All engineering students completing the final year of manufacturing and mechanical engineering at Swinburne University of Technology must undertake a comprehensive final year project encompassing many areas of research, design, analysis, or management, often integrating many of these aspects. It is often the assessment of the project, not the pursuit of it by the student that presents difficulties particularly with respect to bias by academic assessors. Hence it is difficult to compare and quantify the final results of a cohort of projects resulting from many different supervisors. In an attempt to make the assessment process free from bias; a multi valiant set of assessment procedures have been introduced. In all seven steps are involved in the assessment procedure, only one of which is directly dependent on the supervisors, thus reducing their influence on the final grade. The results of this assessment procedure have produced a spread in the series of grades or results, whereas in previous years an obvious bias was seen in relation to the supervisor student relationship. The current assessment procedure has been shown to be bias-free with regards to high or low grades and was a reflection of students' grades in other subjects. Overall, there seems to be satisfaction by both staff and the student cohort in the overall final marks achieved.
Additional file 1 of Expression of ACE2 and a viral virulence-regulating factor CCN family member 1 in human iPSC-derived neural cells: implications for COVID-19-related CNS disorders
Creators: name: Kase, Yoshitaka
name: Okano, Hideyuki
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Additional file 1: Figure S1. Expression of CNN1 (Cyr61) increased 24 hours after SARS-CoV-2 infection of small intestinal organoids. These data were obtained from reference [16]. Values in the line graphs represent the mean ± SD.
A Proactive Risk-Aware Robotic Sensor Network for Critical Infrastructure Protection
Creators: name: McCausland, Jamieson
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: robotic sensor network
risk awareness
self-organization
territorial security
critical infrastructure protection
genetic algorithm
fuzzy logic

description: In this thesis a Proactive Risk-Aware Robotic Sensor Network (RSN) is proposed for the application of Critical Infrastructure Protection (CIP). Each robotic member of the RSN is granted a perception of risk by means of a Risk Management Framework (RMF). A fuzzy-risk model is used to extract distress-based risk features and potential intrusion-based risk features for CIP. Detected high-risk events invoke a fuzzy-auction Multi-Robot Task Allocation (MRTA) algorithm to create a response group for each detected risk. Through Evolutionary Multi-Objective (EMO) optimization, a Pareto set of optimal robot configurations for a response group will be generated using the Non-Dominating Sorting Genetic Algorithm II (NSGA-II). The optimization objectives are to maximize sensor coverage of essential spatial regions and minimize the amount of energy exerted by the response group. A set of non-dominated solutions are produced from EMO optimization for a decision maker to select a single response. The RSN response group will re-organize based on the specifications of the selected response.
Tracing Biogeochemical Processes Using Sulfur Stable Isotopes: Two Novel Applications
Creators: name: Cousineau, Mélanie L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: sulfur stable isotope
microbial sulfate reduction
isotopic fractionation
Cretaceous-Paleogene extinction
Deccan volcanism
Chicxulub impact

description: Abstract Dissimilatory microbial sulfate reduction (MSR) The specific objectives of the study were to provide the first measurements of sulfur isotope fractionation associated with acidophilic sulfate reducing-microorganisms, and to examine whether pH influences sulfur fractionation during MSR. The fractionation associated with the strains investigated was comparable to that of neutrophilic strains with similar metabolisms (4-12‰), but varied with pH. Two fractionation regimes were identified: one regime is consistent with fractionation during exponential growth, while the other – not identified previously - is not linked to active sulfate reduction and may result from internal sulfate accumulation. This would represent the first measurement of sulfur fractionation during sulfate uptake, the first step of MSR. Geological processes at the Cretaceous-Paleogene (KPg) boundary The KPg boundary is associated with one of the largest biological extinctions in the history of our planet. Two major geologic events - the Chicxulub bolide impact with evaporite terrane and the eruption of the Deccan continental flood basalts - coincide with the KPg boundary and have been identified as possible triggers for the extinctions, but their relative timing remains unresolved. The objectives of this study were to identify the contribution of these processes to the sulfur burden in the sedimentary environment of two freshwater KPg sections, and to determine their relative timing. The results demonstrate that the peak of Deccan volcanism post-dates the Chicxulub impact and the associated abrupt KPg mass extinction, thus precluding a direct volcanic causal mechanism, but shedding light on the underlying causes for the delayed recovery of ecosystems in the early Paleogene.
Widening the circle: managing discussion forums in a growing online program
Creators: name: Mazzolini, Margaret
name: Maddison, Sarah
Publisher: name: Swinburne
Year: 2024

description: Swinburne Astronomy Online (SAO) is an online graduate program with students and instructors located in over 30 countries around the globe. The use of asynchronous, assessable discussion forums is a central feature of SAO. These ‘online asynchronous tutorials’ were introduced partly with the intention of breaking down the isolation of distance education, but mainly to encourage active learning in an online education format. SAO has now completed nine semesters, student numbers have increased steadily and instructors have come and gone. Innovative teaching programs can fall into the trap of being manageable when small, only to have quality control become an issue as enrolments grow. Initial enthusiasm of both students and instructors can die down as the novelty wears off. However in the case of SAO, as the program has grown, the format used for discussion forums has proven to be scaleable and remains a central, highly popular feature of SAO. Coordinating and training geographically dispersed instructors requires careful thought and planning, however student and instructor enthusiasm remains high.
Using routine health information data for research in low- and middle-income countries: a systematic review
Creators: name: Hung, Yuen W.
name: Hoxha, Klesta
name: Irwin, Bridget R.
name: Law, Michael R.
name: Grépin, Karen A.
Publisher: name: BioMed Central
Year: 2020

description: Background: Routine health information systems (RHISs) support resource allocation and management decisions at all levels of the health system, as well as strategy development and policy-making in many low- and middle-income countries (LMICs). Although RHIS data represent a rich source of information, such data are currently underused for research purposes, largely due to concerns over data quality. Given that substantial investments have been made in strengthening RHISs in LMICs in recent years, and that there is a growing demand for more real-time data from researchers, this systematic review builds upon the existing literature to summarize the extent to which RHIS data have been used in peer-reviewed research publications. Methods: Using terms ‘routine health information system’, ‘health information system’, or ‘health management information system’ and a list of LMICs, four electronic peer-review literature databases were searched from inception to February 202,019: PubMed, Scopus, EMBASE, and EconLit. Articles were assessed for inclusion based on pre-determined eligibility criteria and study characteristics were extracted from included articles using a piloted data extraction form. Results: We identified 132 studies that met our inclusion criteria, originating in 37 different countries. Overall, the majority of the studies identified were from Sub-Saharan Africa and were published within the last 5 years. Malaria and maternal health were the most commonly studied health conditions, although a number of other health conditions and health services were also explored. Conclusions: Our study identified an increasing use of RHIS data for research purposes, with many studies applying rigorous study designs and analytic methods to advance program evaluation, monitoring and assessing services, and epidemiological studies in LMICs. RHIS data represent an underused source of data and should be made more available and further embraced by the research community in LMIC health systems.
Experimental study of wind induced suction on flat roofs.
Creators: name: Ghariani, Samia.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Engineering, Civil.

description: A 1:10 scale model building previously tested in the NRCC 9$m \times 9m$ wind tunnel was reproduced with a more exaggerated scale of 1:100 in a smaller wind tunnel and tested. Also tested was a half of the building cut along the line of symmetry and with various heights. The purpose of the testing was (1) to examine the repeatability of the roof pressure patterns with a more exaggerated scaling factors, and (2) to explore the feasibility of using a portion of the building for the testing of structural details against wind action. It was confirmed that the proposed simulation of only a half or even less portion of the building at various scaling factors can be a useful wind tunnel testing method which can reproduce the previously established full building test results as long as the parapet height ratio is kept constant and the wind tunnel blockage ratio is kept minimal.
Micro-fluidic switchable photonic band-gap device
Creators: name: Domachuk, P.
name: Nguyen, H. C.
name: Eggleton, B. J.
name: Straub, M.
name: Gu, Min
Publisher: name: Swinburne
Year: 2024

description: We present a novel fabrication method for micro-photonic elements utilizing a transverse photonic band-gap fiber. We then tune the optical response of this device by the introduction of fluids into the micro-structure of the fiber.
The Meaning of Being an Oncology Nurse: Investing to Make a Difference
Creators: name: Davis, Lindsey Ann
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: the meaning of being an oncology nurse
oncology nursing
the lived experience
interpretive phenomenology
investing to make a difference

description: The landscape of cancer care is evolving and as a result nursing care continues to develop and respond to the changing needs of oncology patients and their families. There is a paucity of qualitative research examining the experience of being an oncology nurse on an inpatient unit. Therefore, a qualitative study using an interpretive phenomenological approach has been undertaken to discover the lived experience of being an oncology nurse. In-depth tape recorded interviews has been conducted with six oncology nurses who worked on two adult inpatient oncology units. Van Manen’s (1990) interpretive phenomenological approach has been used to analyze the data by subjecting the transcripts to an analysis both line by line and as a whole. The overarching theme of the interviews is: Investing to Make a Difference. The themes that reflect this overarching theme are: Caring for the Whole Person, Being an Advocate, Walking a Fine Line, and Feeling Like You are Part of Something Good. Oncology nurses provide care for their patients through a holistic lens that further enhances how they come to know their patients. Over time, relationships with patients and families develop and these nurses share that balancing the emotional aspects of their work is key in being able to continue to invest in their work and in these relationships. Their investment is further evident as oncology nurses continuously update their knowledge, for example, of treatment regimes, medication protocols, and as they champion their patients wishes and needs. As nurses develop their own identities as oncology nurses, they in turn enhance the team with their emerging skill and knowledge. These research findings serve to acknowledge the meaning of oncology nurses’ work and inform the profession’s understanding of what it means to be an oncology nurse.
A New Approach to Standardize Multicenter Studies: Mobile Lab Technology for the German Environmental Specimen Bank
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2014

description: Technical progress has simplified tasks in lab diagnosis and improved quality of test results. Errors occurring during the pre-analytical phase have more negative impact on the quality of test results than errors encountered during the total analytical process. Different infrastructures of sampling sites can highly influence the quality of samples and therewith of analytical results. Annually the German Environmental Specimen Bank (ESB) collects, characterizes, and stores blood, plasma, and urine samples of 120-150 volunteers each on four different sampling sites in Germany. Overarching goal is to investigate the exposure to environmental pollutants of non-occupational exposed young adults combining human biomonitoring with questionnaire data. We investigated the requirements of the study and the possibility to realize a highly standardized sampling procedure on a mobile platform in order to increase the required quality of the pre-analytical phase. The results lead to the development of a mobile epidemiologic laboratory (epiLab) in the project "Labor der ZukunftŁ (futures lab technology). This laboratory includes a 14.7 m2reception area to record medical history and exposure-relevant behavior, a 21.1 m2examination room to record dental fillings and for blood withdrawal, a 15.5 m2biological safety level 2 laboratory to process and analyze samples on site including a 2.8 m2personnel lock and a 3.6 m2cryofacility to immediately freeze samples. Frozen samples can be transferred to their final destination within the vehicle without breaking the cold chain. To our knowledge, we herewith describe for the first time the implementation of a biological safety laboratory (BSL) 2 lab and an epidemiologic unit on a single mobile platform. Since 2013 we have been collecting up to 15.000 individual human samples annually under highly standardized conditions using the mobile laboratory. Characterized and free of alterations they are kept ready for retrospective analyses in their final archive, the German ESB. Quelle: http://www.plosone.org
Europeanization and Nation-Building Process: The Case of Scottish Cultural Heritage Policies
Creators: name: Cantin, Caroline
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Europeanization
Scotland
Cultural Heritage Policies
Identity

description: Our thesis discusses the issue of Europeanization in light of Scottish cultural heritage policies since devolution. This sectoral public policy is not the subject of much attention, but this thesis wants to fill the gap. This thesis also raises the questions of identity in the field of cultural heritage. We tend to determine the forces that are involved in the construction of the Scottish identity post-devolution. This work is done by keeping in mind the fact that Scotland is torn between the European and the British influences. In order to operationalize our object of study, we identify six variables that are part of the EU public policies. These variables are the economic and social justifications of cultural public policies, the importance of cultural democracy, the cultural development of regions, the EU policy process and the decision-making process, the emphasis placed on the development of partnerships and the ambivalence of the notion of the EU identity. Our analysis reveals that all of these variables are present in Scottish cultural heritage policies. The omnipresence of all these variables is significant. Nevertheless, because of the limited extent of our work, we consider that it is more appropriate to assert that policy convergence is taking place in Scotland instead of concluding that Scottish cultural heritage policies are openly Europeanized. Our thesis also shows that the presence of these variables in Scottish cultural heritage policies since devolution is an efficient way for Scotland to assert its difference from the UK. Indeed, for almost all of these variables, Scotland’s position tends to differ from the UK.
The Technology-to-Performance Chain: How Lead Management Systems Drive Inside Sales Performance
Creators: name: Ohiomah, Alhassan Abdullahi
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Inside Sales
Lead Management
Lead Management Systems
PLS-SEM
Sales Performance

description: Understanding how technology usage influences performance in the inside sales industry has become an important issue for practitioners. Yet, there is a dearth of literature in this area. Inside sales are sales that are performed remotely using the phone or Internet technologies. Leads (i.e., potential customers) are the life-blood of any inside sales setting, and their effective management is crucial for business success. Lead management systems are information technology (IT) tools designed to automate and support effective lead management. This study developed a conceptual model based on the Technology-Task-Fit (TTF) theory, capturing the impact of lead management systems on inside sales performance through the following mediating mechanisms: task characteristics (call productivity and effort on lead follow-up), selling behaviour (adaptive selling) and salesperson characteristics (salesperson’s competency). To validate this model, we conducted an empirical study with 108 responses collected from sales managers and decision makers. Using PLS-SEM for the analysis, our findings show that the use of lead management systems affects inside sales performance via improving salespeople’s adaptive selling, effort on lead follow-up and competency. The findings of this study contributes to the inside sales literature, and also educate practitioners of the key enablers of inside sales performance and technology usage approaches to the inside sales process.
Reverse Engineering Object-Oriented Systems into Umple: An Incremental and Rule-Based Approach
Creators: name: Garzón, Miguel Alejandro
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Unified Modeling Language
Object-oriented programming
reverse engineering
Umple
modeling
program comprehension

description: This thesis investigates a novel approach to reverse engineering, in which modeling information such as UML associations, state machines and attributes is incrementally added to code written in Java or C++, while maintaining the system in a textual format. Umple is a textual representation that blends modeling in UML with programming language code. The approach, called umplification, produces a program with behavior identical to the original one, but written in Umple and enhanced with model-level abstractions. As the resulting program is Umple code, our approach eliminates the distinction between code and model. We implemented automated umplification in a tool called the Umplificator. The tool is rule-driven: code, including Umple code, is parsed and processed into an internal representation, which is then operated on by rules; transformed textual code and model, in Umple, is then generated. The rules used to transform code to model have been iteratively refined by using the tool on a variety of open-source software systems. The thesis consists of three main parts. The first part (Chapters 1 and 2) present the research questions and research methodology, as well as introducing Umple and the background necessary to understand the rest of the thesis. The umplification method is presented at increasing levels of detail through Chapters 3 and 4. Chapters 5 and 6 present the tool and evaluation of our approach, respectively. An analysis of related work, and comparison to our own, appears in Chapter 7. Finally, conclusions and future work directions are presented in Chapter 8.
Les deux derniers films 'Harry Potter' : marqueurs sonores et thèmes narratifs
Creators: name: More, Noëlie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Harry Potter
associations
thèmes narratifs
audiovisuel
musique de film

description: Considérée comme une histoire pour enfants et adolescents, la saga Harry Potter, tout comme la saga Star Wars dans les années 1980, est devenue un véritable phénomène culturel et intergénérationnel. L'impact de ces livres d'abord, puis des films ensuite, se ressent toujours et ce, malgré leur conclusion en 2011. Beaucoup d'auteurs se sont principalement intéressés à la partie narrative de la saga Harry Potter en interprétant les différents sens politique, psychologique, social, etc., mais sans jamais s'attarder réellement sur la musique des films. 6Mon attention dans ce projet se portera sur la musique des deux derniers films de l'octalogie, composée par Alexandre Desplat. L'objectif de la thèse est de déterminer au moyen de diverses approches comment les thèmes narratifs principaux des deux derniers films de la saga Harry Potter (Les Reliques de la Mort, Parties I et II) sont illustrés par des marqueurs sonores. Nous nous intéresserons à l'illustration de la magie dans la Partie I en nous basant sur la théories critique de la musique de film de Claudia Gorbman en premier lieu, avant de discuter du rôle dramatique de Lily's Theme dans la Partie II en nous basant sur des études sur l'Éternel Féminin et certaines approches en musique et image de Lori Burns. Dans une dernière partie, nous montrerons comment les marqueurs sonores du Bien, de l'héroïsme et du Mal peuvent être compris en terme d'associations culturelles dans la scène du Duel Final de la Partie II avant d'analyser comment la musique agit en tant qu'agent narratif indépendant de l'image en nous basant sur les approches de Robert Hatten (marqué/non marqué) et de Steve Larson (attentes de l'auditeur). Ces approches nous permettent de montrer comment la musique participe à la création d'un univers audiovisuel cohérent et unifié avec l'image dans les deux derniers films de Harry Potter.
Additional file 1 of Perioperative risk factors predict one-year mortality in patients with acute type-A aortic dissection
Creators: name: Yanwei Yang
name: Jiayi Xue
name: Huixian Li
name: Jiaqi Tong
name: Jin, Mu
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Additional file 1. Figure S1. Flow diagram
Leaders can learn to change; some do: a qualitative study
Creators: name: Jones, Robert
name: Kriflik, George
Publisher: name: Swinburne
Year: 2024

description: The behaviour of organisational subordinates is significantly affected by the attitudes and actions of their supervisor. By changing themselves, leaders can therefore have a crucial impact not only on the behaviour of their subordinates but also on the extent to which those subordinates perceive that they are achieving their organisational potential. This paper presents a conceptual model of the process through which organisational leaders can attempt to change themselves with the objective of changing the behaviour of their subordinates. Using a grounded methodology, data has been collected and analysed from a large Australian public sector bureaucracy by means of participant observation, document analysis, personal interviews. The model gives further support to the role of cognitive processes in social learning theory. The key focus of this paper is on the evidence of leadership competencies being learnt, and in particular how leaders can learn to change their own behaviours.
Characterization of the Interactions of the Bacterial Cell Division Regulator MinE
Creators: name: Hafizi, Fatima
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: cell division
MinE
MinD
mitosis
NMR
CD
HSQC
lipids
membrane binding
Hill Equation
detergents
bicelles
micelles
ATPase activity
binding affinity
peptide
FtsZ
kinetics
cooperativity

description: Symmetric cell division in gram-negative bacteria is essential for generating two equal-sized daughter cells, each containing cellular material crucial for growth and future replication. The Min system, comprised of proteins MinC, MinD and MinE, is particularly important for this process since its deletion leads to minicells incapable of further replication. This thesis focuses on the interactions involving MinE that are important for allowing cell division at the mid-cell and for directing the dynamic localization of MinD that is observed in vivo. Previous experiments have shown that the MinE protein contains an N-terminal region that is required to stimulate MinD-catalyzed ATP hydrolysis in the Min protein interaction cycle. However, MinD-binding residues in MinE identified by in vitro MinD ATPase assays were subsequently found to be buried in the hydrophobic dimeric interface in the MinE structure, raising the possibility that these residues are not directly involved in the interaction. To address this issue, the ability of N-terminal MinE peptides to stimulate MinD activity was studied to determine the role of these residues in MinD activation. Our results implied that MinE likely undergoes a change in conformation or oligomerization state before binding MinD. In addition we performed circular dichroism spectroscopy of MinE. The data suggest that direct interactions between MinE and the lipid membrane can lead to conformational changes in MinE. Using NMR spectroscopy in an attempt to observe this structure change, different membrane-mimetic environments were tested. However the results strongly suggest that structural studies on the membrane-bound state of MinE will pose significant challenges. Taken together, the results in this thesis open the door for further exploration of the interactions involving MinE in order to gain a better understanding of the dynamic localization patterns formed by these proteins in vivo.
Myth-analysis, myth and the social imaginary in Nerval's writing Mythanalyse, mythe et imaginaire social dans l’écriture nervalienne
Creators: name: AZOUGAGH, Ikram
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 440107
subject: Social and cultural anthropology
classificationCode: 441008
subject: Sociology of culture
classificationCode: 470516
subject: Literature in French

description: Les mythes dévoilent une vision unique du monde, ils influencent la culture, la pensée philosophique et l'histoire des sociétés anciennes. La mythanalyse et la mythocritique se complètent pour mieux comprendre l'imaginaire de l'écrivain. Nerval exploite cette richesse mythique en entrelaçant mots et symboles pour créer une magie littéraire. Son écriture transcende les frontières du réel, invitant le lecteur à un fascinant voyage à travers l'éternelle pertinence des mythes, source d'inspiration intemporelle. Résistants au temps, les mythes évoluent et se nourrissent de la société et de la psyché humaine, suscitant des questions sur les énigmes de l'existence et perpétuant ainsi leur mystérieux pouvoir.
Evaluation of Met-Val-Lys as a Renal Brush Border Enzyme-Cleavable Linker to Reduce Kidney Uptake of 68Ga-Labeled DOTA-Conjugated Peptides and Peptidomimetics
Creators: name: Bendre, Shreya
name: Zhang, Zhengxing
name: Kuo, Hsiou-Ting
name: Rousseau, Julie
name: Zhang, Chengcheng
name: Merkens, Helen
name: Roxin, Áron
name: Bénard, François
name: Lin, Kuo-Shyan
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: High kidney uptake is a common feature of peptide-based radiopharmaceuticals, leading to reduced detection sensitivity for lesions adjacent to kidneys and lower maximum tolerated therapeutic dose. In this study, we evaluated if the Met-Val-Lys (MVK) linker could be used to lower kidney uptake of ⁶⁸Ga-labeled DOTA-conjugated peptides and peptidomimetics. A model compound, [⁶⁸Ga]Ga-DOTA-AmBz-MVK(Ac)-OH (AmBz: aminomethylbenzoyl), and its derivative, [⁶⁸Ga]Ga-DOTA-AmBz-MVK(HTK01166)-OH, coupled with the PSMA (prostate-specific membrane antigen)-targeting motif of the previously reported HTK01166 were synthesized and evaluated to determine if they could be recognized and cleaved by the renal brush border enzymes. Additionally, positron emission tomography (PET) imaging, ex vivo biodistribution and in vivo stability studies were conducted in mice to evaluate their pharmacokinetics. [⁶⁸Ga]Ga-DOTA-AmBz-MVK(Ac)-OH was effectively cleaved specifically by neutral endopeptidase (NEP) of renal brush border enzymes at the Met-Val amide bond, and the radio-metabolite [⁶⁸Ga]Ga-DOTA-AmBz-Met-OH was rapidly excreted via the renal pathway with minimal kidney retention. [⁶⁸Ga]Ga-DOTA-AmBz-MVK(HTK01166)-OH retained its PSMA-targeting capability and was also cleaved by NEP, although less effectively when compared to [⁶⁸Ga]Ga-DOTA-AmBz-MVK(Ac)-OH. The kidney uptake of [⁶⁸Ga]Ga-DOTA-AmBz-MVK(HTK01166)-OH was 30% less compared to that of [⁶⁸Ga]Ga-HTK01166. Our data demonstrated that derivatives of [⁶⁸Ga]Ga-DOTA-AmBz-MVK-OH can be cleaved specifically by NEP, and therefore, MVK can be a promising cleavable linker for use to reduce kidney uptake of radiolabeled DOTA-conjugated peptides and peptidomimetics.