NanoSolveIT Project: driving Nanoinformatics research to develop innovative and integrated tools for in silico nanosafety assessment
Creators: name: Afantitis, Antreas
name: Melagraki, Georgia
name: Isigonis, Panagiotis
name: Tsoumanis, Andreas
name: Varsou, Dimitra Danai
name: Valsami-Jones, Eugenia
name: Papadiamantis, Anastasios
name: Ellis, Laura-Jayne A
name: Sarimveis, Haralambos
name: Doganis, Philip
name: Karatzas, Pantelis
name: Tsiros, Periklis
name: Liampa, Irene
name: Lobaskin, Vladimir
name: Greco, Dario
name: Serra, Angela
name: Kinaret, Pia Anneli Sofia
name: Saarimäki, Laura Aliisa
name: Grafström, Roland
name: Kohonen, Pekka
name: Nymark, Penny
name: Willighagen, Egon
name: Puzyn, Tomasz
name: Rybinska-Fryca, Anna
name: Lyubartsev, Alexander
name: Jensen, Keld Alstrup
name: Brandenburg, Jan Gerit
name: Lofts, Stephen
name: Svendsen, Claus
name: Harrison, Samuel
name: Maier, Dieter
name: Tamm, Kaido
name: Jänes, Jaak
name: Sikk, Lauri
name: Dusinska, Maria
name: Longhin, Eleonora
name: Rundén-Pran, Elise
name: Mariussen, Espen
name: Yamani, Naouale El
name: Unger, Wolfgang
name: Radnik, Jörg
name: Tropsha, Alexander
name: Cohen, Yoram
name: Leszczynski, Jerzy
name: Hendren, Christine Ogilvie
name: Wiesner, Mark
name: Winkler, David
name: Suzuki, Noriyuki
name: Yoon, Tae Hyun
name: Choi, Jang-Sik
name: Sanabria, Natasha
name: Gulumian, Mary
name: Lynch, Iseult
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Nanotechnology has enabled the discovery of a multitude of novel materials exhibiting unique physicochemical (PChem) properties compared to their bulk analogues. These properties have led to a rapidly increasing range of commercial applications; this, however, may come at a cost, if an association to long-term health and environmental risks is discovered or even just perceived. Many nanomaterials (NMs) have not yet had their potential adverse biological effects fully assessed, due to costs and time constraints associated with the experimental assessment, frequently involving animals. Here, the available NM libraries are analyzed for their suitability for integration with novel nanoinformatics approaches and for the development of NM specific Integrated Approaches to Testing and Assessment (IATA) for human and environmental risk assessment, all within the NanoSolveIT cloud-platform. These established and well-characterized NM libraries (e.g. NanoMILE, NanoSolutions, NANoREG, NanoFASE, caLIBRAte, NanoTEST and the Nanomaterial Registry (&gt;2000 NMs)) contain physicochemical characterization data as well as data for several relevant biological endpoints, assessed in part using harmonized Organisation for Economic Co-operation and Development (OECD) methods and test guidelines. Integration of such extensive NM information sources with the latest nanoinformatics methods will allow NanoSolveIT to model the relationships between NM structure (morphology), properties and their adverse effects and to predict the effects of other NMs for which less data is available. The project specifically addresses the needs of regulatory agencies and industry to effectively and rapidly evaluate the exposure, NM hazard and risk from nanomaterials and nano-enabled products, enabling implementation of computational ‘safe-by-design’ approaches to facilitate NM commercialization.