cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Relationship between MTHFR, MTRR gene polymorphisms and H-type hypertension: a systematic review and meta-analysis
Creators: name: Gao, Lan
name: Dong, Lisen
name: Niu, Yixuan
name: Jian, Meiyun
name: Yang, Junli
name: Chen, Gang
name: Tang, Hailang
name: Su, Changhai
name: Xu, Lei
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: The relationship between methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms and H-type hypertension susceptibility has been deeply analysed, but the conclusions are not consistent. Therefore, we carried out a meta-analysis aimed at assessing the relationship exactly. Six English databases (PubMed, Embase, EBSCO, ScienceDirect, Cochrane Library, and Web of Science) and four Chinese databases (China Biological Medicine, WanFang, China Science and Technology Journal, and China National Knowledge Infrastructure) were used for searching studies from inception to August 2023. MTHFR C677T/A1298C and MTRR A66G genetic polymorphisms were evaluated. A total of 24 papers were included in our research, including 3649 H-type hyperpietics, 2772 non-H-type hyperpietics, and 2149 healthy controls. Our analysis shows that MTHFR C677T polymorphism showed significant association with H-type hypertension in both healthy individuals and non-H-type hyperpietics (TT vs. CC: OR = 3.43, 95% CI = 2.48–4.75). Further subgroup analysis based on geography revealed that homocysteine levels in the southern Chinese population were more susceptible to MTHFR C677T polymorphism (p < 0.05). However, there was no significant association in all genetic models for the polymorphisms of MTHFR A1298C and MTRR A66G. MTHFR C677T polymorphisms are associated with H-type hypertension in non-H-type hyperpietics and healthy individuals.
E06812: Greek account book from Hermopolis (Middle Egypt), listing institutions dedicated to *Kollouthos (physician and martyr of Antinoopolis, S00641), *Phoibammon (presumably the soldier and martyr of Assiut, S00080), and *Mary (Mother of Christ, S00033); datable to the beginning of the 7th century.
Creators: name: Gschenke
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: P.Lond.Copt. I 1077 = BM 1077

τοῦ ἁγίου Κολλούθ(ου)

‘of saint Kollouthos’

τοῦ ἁγίου Φοιβάμμ(ωνος)

‘of saint Phoibammon’

τῆς ἁγίας Μαρίας

‘of saint Mary’

(Text and trans. W. E. Crum)
E06814: Coptic receipt from Hermopolis (Middle Egypt), issued by the dikaion of a monastery dedicated to *Michael, the Archangel (S00181); datable to the 7th/8th century.
Creators: name: Gschenke
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: P.Lond.Copt. I 1049 = BM 1049

The receipt was issued to an oil merchant for an agreed payment in kind.

+ ⲡⲇⲓⲕⲁⲓⲟⲛ ⲙⲡⲁⲣⲭⲁⲅⲅⲉⲗⲟⲥ ⲙⲓⲭⲁⲏⲗ

‘The dikaion of the Archangel Michael’

(Text and trans. W. E. Crum)
E06813: Coptic receipts from Hermopolis (Middle Egypt), issued by the dikaion of a monastery dedicated to *Phoibammon (presumably soldier and martyr of Assiut, S00080); datable to the 7th/8th century.
Creators: name: Gschenke
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: P.Lond.Copt. I 1055 = BM 1055

Two receipts issued by the monastery of saint Phoibammon to a man named Kollouthos concerning deliveries of measures of corn.

ⲡⲇⲓⲕⲁⲓⲟⲛ ⲛⲫⲁⲅⲓⲟⲥ ⲫⲟⲓⲃⲁⲙⲙⲱⲛ

‘The dikaion of saint Phoibammon’

(Text and trans. W. E. Crum)
Additional file 1 of Interpretable machine learning model for predicting acute kidney injury in critically ill patients
Creators: name: Li, Xunliang
name: Wang, Peng
name: Zhu, Yuke
name: Zhao, Wenman
name: Pan, Haifeng
name: Wang, Deguang
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Supplementary Material 1
E06815: Coptic guarantee document from Hermopolis (Middle Egypt), issued to the dikaion of a monastery dedicated to *John the Baptist (S00020), mentioning also a confraternity of the same saint; datable to the 8th century.
Creators: name: Gschenke
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: P.Lond.Copt. I 1046 = BM 1046

The monastery of saint John is addressed in line 1–2 as follows:

ⲉⲓⲥϩⲁⲓ ⲉⲡⲇⲓⲕⲁⲓⲟⲛ ⲙⲡⲙⲁ ⲛⲫⲁⲅⲓⲟⲥ ⲓⲱϩⲁⲛⲛⲏⲥ ⲙⲡ[ⲡⲉⲣⲓⲡⲁⲧⲟⲥ?

‘… I am writing to he dikaion of the place of saint John in the [Peripatos?]’

The confraternity of the same saint is mentioned in line 7 as follows:

ⲡⲟⲓⲕ]ⲟⲛⲟⲙⲟⲥ ⲙⲡⲉⲫⲓⲗⲟⲡⲟⲛⲓⲟⲛ ⲛⲫⲁⲅⲓⲟⲥ ⲓⲱϩⲁⲛⲛⲏⲥ ⲙⲡⲡⲉⲣⲓⲡⲁⲧⲟⲥ

‘… [the] oikonomos of the confraternity of saint John in the Peripatos.’

(Text W. E. Crum; trans. G. Schenke)
Additional file 3 of Menstruation hygiene management among secondary school students of Chitwan, Nepal:a cross-sectional study
Creators: name: Khanal, Gayatri
name: Shrestha, Niki
name: Adhikari, Kishor
name: Ghimire, Usha
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional File 3: Total number of participants selected from each selected school
title: DIYmodify Factsheet: SKILLS NEEDED: Hob and infill
Creators: name: Barlow, Gillian
name: Bridge, Catherine
Publisher: name: Home Modification Information Clearinghouse
Year: 2017

description: Looks at the skills needed to install a shower infill where there is a hob at the shower and has some tips for DIY.
description: DIYmodify Factsheet SKILLS NEEDED: hob and infill
This project requires MORE SKILLS
What to know before doing this project
E06817: Coptic document from Aswan (Upper Egypt), concerning the payment of a debt, mentioning as one of the witnesses a presbyter of an institution dedicated to *Papnouthios (unspecified, S00882, possibly Paphnoutios of Thebes, founder of a monastery near Ape, S00881); datable to the 7th/8th century.
Creators: name: Gschenke
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: P.Lond.Copt. I 447 = BM 447

In line 28 the witness is mentioned as follows:

+ [ⲁⲛⲟⲕ ….]. ⲡⲉⲡⲣⲉⲥ⟨ⲃⲩ⟩ⲧⲉⲣ[ⲟ]ⲥ ⲙⲡϩⲁⲅⲓⲟⲥ ⲡⲁⲡⲛⲟⲩⲧ[ⲓⲟⲥ] ϯⲟ ⲙⲛ[ⲧⲣⲉ]

‘[I, name], the presbyter of saint Papnoutios, I am a witness.’

(Text W. E. Crum; trans. G. Schenke)
Additional file 1 of Culturally adapted training for community volunteers to improve their knowledge, attitude and practice regarding non-communicable diseases in Vietnam
Creators: name: Pardoel, Zinzi E.
name: Reijneveld, Sijmen A.
name: Lensink, Robert
name: Postma, Maarten J.
name: Trang, Nong Thi Thu
name: Walton, Poppy
name: Swe, Khin Hnin
name: Pamungkasari, Eti Poncorini
name: Koot, Jaap A.R.
name: Landsman, Jeanet A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Development of indole hybrids for potential lung cancer treatment-part I: nitrogen-containing six-membered aromatic heterocycles
Creators: name: Zhao, Shijia
name: Xu, Zhi
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology

description: Lung cancer is the most prevalent invasive malignancy and the leading cause of cancer-related death. Chemotherapy is vital for lung cancer therapy, but multidrug resistance is responsible for the majority of lung cancer fatalities, creating an imperative demand to develop novel chemotherapeutics. Indole is a valuable anti-lung cancer pharmacophore since its derivatives could act on lung cancer cells through various mechanisms. Notably, indole hybrids could inhibit multiple targets simultaneously and have the potential to overcome the shortcomings of traditional chemotherapeutics. Moreover, many indole hybrids such as the indole-pyrimidine hybrid osimertinib and the indole-hydroxamic acid hybrid panobinostat, are either under clinical evaluations or have already been approved for lung cancer therapy. This indicates that the rational design of indole hybrids represents a highly prospective approach for the development of new anti-lung cancer chemotherapeutic agents. This review focuses on exploring the anti-lung cancer therapeutic potential of indole hybrids and delves into their action mechanisms as well as structure-activity correlations, covering articles published between 2021 and present. The ultimate goal is to offer a foundation for the rational design of indole hybrids in the future.
E06816: Coptic rent agreement from Hermopolis (Middle Egypt), mentioning a monastery dedicated to *John the Baptist (S00020) and a confraternity presumably of the same saint; datable to the 8th century.
Creators: name: Gschenke
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: P.Lond.Copt. I 1023 = BM 1023

The fragmentary document mentions the institution and the confraternity in line 2–3 as follows:

ⲛⲫⲁⲅⲓⲟ]ⲥ ⲓⲱϩⲁⲛⲏⲥ ⲙⲡⲡⲉⲣⲓⲡⲟⲧⲏⲥ ϩⲓⲧⲛ ⲁⲡⲁ . . . . ⲡ]ⲇⲓⲁⲇⲟⲭⲟⲥ ⲙⲛ ⲡⲥⲉⲉⲡⲉ ⲙⲡⲉⲫⲓⲗⲟⲡⲟⲛ[ⲟⲥ]

‘… of saint] John in the Peripatos, represented through Apa …, the diadochos, and the rest of the confraternity …’

(Text W. E. Crum; trans. G. Schenke)
Additional file 1 of Effect of a juggling-based physical activity on postural stability, reaction time, and attention focus in older adults: a randomized crossover study
Creators: name: Malik, Jakub
name: Główka, Natalia
name: Jelonek, Wojciech
name: Stemplewski, Rafał
name: Maciaszek, Janusz
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Additional file 1: “Bonferroni post hoc comparison between groups for significant main or interaction effects”
title: Früher „fit“ durch „frühes Fitten“? Erste Erfahrungen mit der frühen Anpassung nach Cochlea Implantation
Creators: name: Günther, Stefanie
name: Helbig, Silke
name: Stöver, Timo
name: Baumann, Uwe
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: Die HNO-Universitätsklinik Frankfurt bietet Cochlea-Implantat Patienten ein neues Behandlungskonzept zur Erstanpassung des Prozessors an. Bislang wurde dieser 4-5 Wochen nach der Operation aktiviert, damit die Gewebereaktion im Implantatbereich durch den Einheilungsprozess sicher beendet wird. [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 88. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie
title: Apoptose-Signaling im Cholesteatom
Creators: name: Leichtle, Anke
name: Därr, Markus
name: Bruchhage, Karl-Ludwig
name: Wollenberg, Barbara
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Apoptose ist ein wichtiger Faktor für die Entwicklung und Homöostase vieler Krankheiten. Charakterisiert wird er durch einen kontrollierten, durch Genexpression programmierten Zelltod, indiziert durch DNA-Fragmente, Zellorgan- Kompartimentierung und Eliminierung mittels Phagozytose.[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 88. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie
E06818: Fragment of a Coptic Encomion on *Pjoore (martyr of Panopolis, S02599), listing also feast days, for *Apa Elias (bishop of Psoi/Ptolemais, S02598), and for *Arsenios and Loukios (ascetics of Syrian origin, and martyrs near Panopolis, S02600); datable to the 7th/8th century.
Creators: name: Gschenke
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: P.Lond.Copt. I 337 = BM 337

In lines 6–7 the saint whose name means ‘the strong’ is invoked as follows:

ⲱ ⲡϫⲱⲱⲣⲉ ⲛⲁⲙⲉ ⲕⲁⲧⲁ ⲡⲉϥⲣⲁⲛ ⲉϣⲁⲣⲉ ⲡⲣⲱⲙⲉ ⲧⲙⲁⲉⲓⲟ ⲁⲛ ⲙⲙⲁⲧⲉ ϩⲙ ⲡⲣⲁⲛ ⲁⲗⲗⲁ ϩⲙ ⲛⲉⲡⲣⲁⲝⲓⲥ ⲡⲉⲧⲉⲙⲡⲟⲩⲣⲡⲉϥⲙⲉⲉⲩⲉ
ⲉⲧⲁϩⲙⲉϥ ⲉⲡⲇⲓⲡⲛⲟⲛ ⲁⲩϩⲉ ⲉⲣⲟϥ ⲉϥⲟ ⲛϣⲟⲣⲡ ϩⲛ ⲧⲉⲑⲟⲩⲥⲓⲁ

‘Pjoore true to his name! The man thus exceedingly justified by name as well as by actions. The one who was forgotten to be invited to the meal, he was found to be the first through sacrifice.’

Then follow the two dates, one written in the margins, before the encomion begins, but breaks off soon after:

ⲁⲡⲁ ϩⲏⲗⲓⲁⲥ ⲡⲉⲡⲓⲥⲕⲟⲡⲟⲥ ⲛⲧⲡⲟⲗⲓⲥ ⲯⲟⲓ ⲭⲟⲓ(ⲁ)ⲭ ⲓⲉ

‘Apa Elias, the bishop of the city Psoi: Choiak 15 [11/12 December]’

ⲟⲙⲁⲓⲟⲥ ⲉϫⲛ ⲛϩⲁⲅⲓⲟⲥ ⲛⲥⲩⲣⲟⲥ ⲗⲟⲩⲅⲓⲟⲥ (ⲕⲁⲓ) ⲁⲣⲥⲉⲛⲓⲟⲥ ⲭⲟⲓ(ⲁ)ⲭ ⲓϛ

‘Likewise for the Syrian saints Loukios and Arsenios: Choiak 16 [12/13 December]’

(Text W. E. Crum; trans. G. Schenke)
Additional file 2 of Culturally adapted training for community volunteers to improve their knowledge, attitude and practice regarding non-communicable diseases in Vietnam
Creators: name: Pardoel, Zinzi E.
name: Reijneveld, Sijmen A.
name: Lensink, Robert
name: Postma, Maarten J.
name: Trang, Nong Thi Thu
name: Walton, Poppy
name: Swe, Khin Hnin
name: Pamungkasari, Eti Poncorini
name: Koot, Jaap A.R.
name: Landsman, Jeanet A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 2
Development of 5-phenylnitro bearing furan-based chalcones as a new class of potent MAO-B inhibitors
Creators: name: Kalathil, Kadeeja Thottungal
name: Pandey, Bishnu Prasad
name: Peedikayil, Arshida Thottile
name: Abdu, Raihan Arikkattel
name: Sreekumari, Rajasree Raghavan
name: Alfagham, Alanoud T.
name: Elgorban, Abdallah M.
name: Kumar, Sunil
name: Kim, Hoon
name: Dev, Sanal
name: Mathew, Bijo
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: The purpose is to synthesize a new class of furan-based chalcone compounds (KD1-KD14) and to investigate their monoamine oxidase (MAO)-A and -B inhibitory activities. The 14 chalcones were synthesized using an open mortar and pestle. Lead molecules were screened via inhibitory activity, BBB permeability, and computation studies. Most of the tested compounds showed promising activity for MAO-B over than MAO-A. Among the molecules, KD1 and KD9 revealed the significant inhibitory potentials toward MAO-B with IC50 values of 0.023 ± 0.004 and 0.015 ± 0.001 µM, respectively, and with high selectivity indices of 723.04 and >2666.66, respectively, over MAO-A. Further, kinetics and reversibility test revealed that both KD1 and KD9 were competitive reversible MAO-B inhibitors with Ki values of 13.5 ± 4.95 and 6.15 ± 0.92 nM, respectively. Additionally, the PAMPA test showed that both KD1 and KD9 compounds permeated the central nervous system. Furthermore, molecular docking and dynamics simulations showed that both the chemicals formed pi-cation and hydrogen bonds with the MAO-B pocket and stabilized the MAO-B over the course of a 100 ns simulation. Our results revealed that KD1 and KD9 are potent selective, reversible, and competitive MAO-B inhibitors.
title: Experimentelle Untersuchung zur CI-Elektrodenfixierung  im Chorda-Fazialis-Winkel
Creators: name: Leinung, Martin
name: Loth, Andreas
name: Adel, Youssef
name: Weiß, Roxanne
name: Stöver, Timo
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: Von den Cochlea-Implantat-Herstellern werden für einen optimalen Resthörerhalt immer dünnere Elektrodendesigns entwickelt. Diese begünstigen jedoch einen teilweisen Rückzug der Elektrode aus der Cochlea (Elektrodenmigration), der auch noch Monate nach dem Eingriff auftreten [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 88. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie
title: Cochlear implantation in patients with common cavity deformity
Creators: name: Li, Yongxin
name: Wei, Xingmei
name: Gong, Yue
name: Chen, Biao
name: Fu, Qianjie
name: Chen, Jingyuan
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Cochlear implantation for patients with common cavity deformity (CCD) can be difficult, with a higher incidence of intra- and post-operative complications; outcomes with CCD patients are also highly variable. In this study, intra- and post-operative complications were compared between [for full text, please go to the a.m. URL]
description: 88. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie
title: DIYmodify Factsheet: SKILLS NEEDED: Metal ramp
Creators: name: Barlow, Gillian
name: Bridge, Catherine
Publisher: name: Home Modification Information Clearinghouse
Year: 2017

description: SKILLS NEEDED to install a metal ramp PLUS some DIY tips on how to do it.
description: DIYmodify Factsheet SKILLS NEEDED: Metal ramp
This project requires BASIC SKILLS
What to know before doing this project
Checklist
Identification of novel Mycobacterium tuberculosis leucyl-tRNA synthetase inhibitors with antibacterial activity
Creators: name: Volynets, Galyna P.
name: Gudzera, Olga I.
name: Lukashov, Segiy S.
name: Gorbatiuk, Oksana B.
name: Usenko, Mariia O.
name: Ruban, Tetiana P.
name: Protopopov, Mykola V.
name: Tarnavskiy, Segiy S.
name: Kotey, Igor M.
name: Bdzhola, Volodymyr G.
name: Prykhod’ko, Andrii O.
name: Lukash, Lubov L.
name: Yarmoluk, Sergiy M.
name: Tukalo, Michael A.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Tuberculosis has become the world’s most lethal infectious disease. A major challenge in treating tuberculosis is the multidrug resistance of Mycobacterium tuberculosis to existing antibiotics. Therefore, there is an urgent need to discover new antituberculosis agents with unexploited mechanisms of action. The aim of the work was to develop inhibitors of mycobacterial leucyl-tRNA synthetase (LeuRS) with antibacterial activity. The virtual screening of compound collection containing about 250,000 ligands into aminoacyl-adenylate binding site of M. tuberculosis LeuRS was performed with AutoDock 4.2 software. The inhibitory activity of compounds toward recombinant LeuRS was studied in aminoacylation assay using 14C-labeled L-leucine. Antibacterial activity was investigated toward M. tuberculosis H37Rv strain under four different conditions. According to the data of biochemical screening, we have found M. tuberculosis LeuRS inhibitors among N-(5-Benzyl-thiazol-2-yl)-2-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-acetamide deivatives, which decrease enzyme activity with IC50 values in micromolar range. The most promising compound, N-(5-Benzyl-thiazol-2-yl)-2-[4-(4-methoxy-phenyl)-1H-tetrazol-5-ylsulfanyl]-acetamide, reveals potent antibacterial activity with the best minimum inhibitory concentration (MIC) value of 4.7 µM. N-(5-Benzyl-thiazol-2-yl)-2-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-acetamide scaffold can be valuable for further biological research and chemical optimization. Using molecular docking approach followed with in vitro aminoacylation assay, we found novel chemical class of Mycobacterium tuberculosis leucyl-tRNA synthetase (LeuRS) inhibitors decreasing the enzyme activity with IC50 values in micromolar range. Among them we identified one compound – N-(5-Benzyl-thiazol-2-yl)-2-[4-(4-methoxy-phenyl)-1H-tetrazol-5-ylsulfanyl]-acetamide, which demonstrates potent antibacterial activity with the MIC value of 4.7 μM.
sj-pdf-1-tar-10.1177_1753466621995040 – Supplemental material for Burden of pulmonary arterial hypertension in England: retrospective HES database analysis
Creators: name: Exposto, Fernando
name: Hermans, Ruben
name: Nordgren, Åsa
name: Taylor, Luke
name: Rehman, Sanam Sikander
name: Ogley, Robert
name: Davies, Evan
name: Yesufu-Udechuku, Amina
name: Beaudet, Amélie
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-pdf-1-tar-10.1177_1753466621995040 for Burden of pulmonary arterial hypertension in England: retrospective HES database analysis by Fernando Exposto, Ruben Hermans, Åsa Nordgren, Luke Taylor, Sanam Sikander Rehman, Robert Ogley, Evan Davies, Amina Yesufu-Udechuku and Amélie Beaudet in Therapeutic Advances in Respiratory Disease
title: DIYmodify Factsheet: SKILLS NEEDED: Rubber ramp
Creators: name: Barlow, Gillian
name: Bridge, Catherine
Publisher: name: Home Modification Information Clearinghouse
Year: 2017

description: SKILLS NEEDED to install a rubber ramp plus some DIY tips.
description: DIYmodify Factsheet SKILLS NEEDED: Rubber ramp
This project requires BASIC SKILLS
What to know doing this project
Checklist
title: Comet: Anwenderfreundliche Vermessung der Cochlea-Länge auf präoperativen Bilddaten
Creators: name: Majdani, Omid
name: Lexow, Jakob
name: Lenarz, Thomas
name: Rau, Thomas
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Länge der Cochlea variiert stark zwischen einzelnen Patienten. Gleichzeitig sind Cochlea-Implantate mit Elektrodenträgern verschiedener Länge auf dem Markt verfügbar. Eine präoperative Bestimmung der Cochlea-Länge ist Voraussetzung, um patientenindividuell[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 88. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie
title: Schmerzfreie MRT Untersuchungen bei Cochlear Implant Patienten
Creators: name: Renninger, Daniel
name: Todt, Ingo
name: Wagner, Jan
name: Seidl, Rainer
name: Ernst, Arne
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: Die Durchführbarkeit von MRT Untersuchungen bei Cochlear Implant Versorgten wird gegenwärtig aufgrund assoziierter Komplikationen limitiert. Das Auftreten von unklarem postoperativem Schwindel, ein Leistungsabfall des Cochlear Implants bei intaktem System oder der begründete Verdacht [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 88. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie
Additional file 3 of Culturally adapted training for community volunteers to improve their knowledge, attitude and practice regarding non-communicable diseases in Vietnam
Creators: name: Pardoel, Zinzi E.
name: Reijneveld, Sijmen A.
name: Lensink, Robert
name: Postma, Maarten J.
name: Trang, Nong Thi Thu
name: Walton, Poppy
name: Swe, Khin Hnin
name: Pamungkasari, Eti Poncorini
name: Koot, Jaap A.R.
name: Landsman, Jeanet A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 3
title: Ð¡Ð¿ÐµÑÐ¸ÑÐ¸ÐºÐ° ÑÐºÑÐ¿ÐµÑÑÐ½Ð¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð² ÑÐ¾ÑÐ¸Ð¾ÑÐµÑ Ð½Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ðµ
title: Specifics of expert activity in a sociotechnical system
Creators: name: Ð¨Ð¸Ð¿ÑÐ½Ð¾Ð²Ð°, ÐÐ»ÑÐ³Ð°
name: "Ð¡Ð¸ÑÑÐµÐ¼Ð½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð² Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ð¸ Ð¸ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ð¸", Ð¼ÐµÐ¶Ð´ÑÐ½Ð°ÑÐ¾Ð´Ð½Ð°Ñ Ð½Ð°ÑÑÐ½Ð¾-Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ°Ñ ÐºÐ¾Ð½ÑÐµÑÐµÐ½ÑÐ¸Ñ (27; 2023; Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³)
Publisher: name: ÐÐÐÐÐ¢ÐÐ¥-ÐÐ ÐÐ¡Ð¡
Year: 2024

description: Ð¡ÑÐ°ÑÑÑ Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° ÑÐ¸Ð»Ð¾ÑÐ¾ÑÑÐºÐ¸Ð¼ Ð°ÑÐ¿ÐµÐºÑÐ°Ð¼ ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð³Ð¸Ð±ÑÐ¸Ð´Ð½ÑÑ Ð¸Ð½ÑÐµÐ»Ð»ÐµÐºÑÑÐ°Ð»ÑÐ½ÑÑ ÑÑÐµÐ´ ÑÐºÑÐ¿ÐµÑÑÐ½Ð¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸, ÐºÐ¾ÑÐ¾ÑÑÐµ ÑÐ²ÑÐ·Ð°Ð½Ñ Ñ
ÑÑÐ°Ð½ÑÐ»ÑÑÐ¸ÐµÐ¹ ÑÐ¼ÑÑÐ»Ð¾Ð² Ð² Ð¸Ð½ÑÐµÑÐ°ÐºÑÐ¸Ð²Ð½ÑÑ ÑÐ¼Ð°ÑÑ ÑÐ¸ÑÑÐµÐ¼Ð°Ñ. Ð ÑÑÐ°ÑÑÐµ Ð¿Ð¾Ð´ÑÐµÑÐºÐ¸Ð²Ð°ÐµÑÑÑ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ð° Ð¿ÑÐµÐµÐ¼ÑÑÐ²ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð¸ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ Ð·Ð½Ð°Ð½Ð¸Ñ, ÑÐºÑÑÑÐ°Ñ Ð² Ð´Ð¸Ð½Ð°Ð¼Ð¸ÐºÐµ Ð½Ð°ÑÐ°ÑÐ¸Ð²Ð°Ð½Ð¸Ñ Ð¿ÑÐµÐ´Ð¼ÐµÑÐ½ÑÑ Ð¾Ð½ÑÐ¾Ð»Ð¾Ð³Ð¸Ð¹. ÐÐ±ÑÑÐ¶Ð´Ð°ÐµÑÑÑ ÑÐ°Ð·Ð»Ð¸ÑÐ¸Ðµ ÑÑÐ±ÑÐµÐºÑÐ° Ð½Ð°ÑÑÐ½Ð¾Ð³Ð¾ Ð¸ ÑÐºÑÐ¿ÐµÑÑÐ½Ð¾Ð³Ð¾ Ð·Ð½Ð°Ð½Ð¸Ñ, Ð° ÑÐ°ÐºÐ¶Ðµ ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ ÐºÐ¾Ð½ÑÐµÐºÑÑÐ½ÑÑ Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹, Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÑÑÑÐ¸Ñ ÐºÐ¾Ð³Ð½Ð¸ÑÐ¸Ð²Ð½ÑÐµ Ð¾ÑÐ¸ÐµÐ½ÑÐ°ÑÐ¸Ð¸ Ð² ÑÐºÑÐ¿ÐµÑÑÐ½Ð¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸. Ð ÑÑÐ¾Ð¹ ÑÐ²ÑÐ·Ð¸ ÑÑÐ²ÐµÑÐ¶Ð´Ð°ÐµÑÑÑ Ð°ÐºÑÑÐ°Ð»ÑÐ½Ð¾ÑÑÑ ÑÐ¸ÑÑÐµÐ¼Ð½Ð¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð¾Ð² ÑÑÐ°Ð½ÑÐ»ÑÑÐ¸Ð¸ ÑÐ¼ÑÑÐ»Ð° Ð² Ð¸Ð½ÑÐµÑÐ°ÐºÑÐ¸Ð²Ð½ÑÑ ÑÐ¸ÑÑÐµÐ¼Ð°Ñ.
description: The article is devoted to the philosophical aspects of the formation of hybrid intellectual environments of expert activity, which are associated with the translation of meanings in interactive smart systems. The article emphasizes the problem of continuity and development of knowledge, hidden in the dynamics of the build-up of subject ontologies. The article discusses the difference between the subject of scientific and expert knowledge, as well as the formation of contextual models that guide cognitive orientations in expert activity. In this regard, the relevance of the system analysis of the mechanisms of meaning translation in interactive systems is asserted.
title: Der retrosigmoidale Zugangsweg beim Vestibularisschwannom aus HNO-ärztlicher Sicht
Creators: name: Schipper, Jörg
name: Klenzner, Thomas
name: Haenggi, Daniel
name: Cornelius, Jan
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: Aus medicolegaler Sicht sind wir als HNO-Ärzte  angehalten, den retrosigmoidalen Zugang (RZ) gemeinsam mit den Kollegen aus  der Neurochirurgie oder nur in Krankenhäusern mit einer neurochirurgischen Hauptabteilung bei der Entfernung von Vestibularschwannomen (VS) einzusetzten.      Im Rahmen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 88. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie
E06819: Coptic funerary stela presumably from Sinnuris in the Fayum invoking a long list of saints, among them the martyrs *Viktor (son of Romanos, S00749), *Phoibammon (soldier and martyr of Assiut, S00080), *George (soldier and martyr, S00259), and *Menas (soldier and martyr of Abu Mena, S00073); datable to the 7th–9th century.
Creators: name: Gschenke
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: UC 16852

The invocation of 'all the saint who have fulfilled the will of God' is made on behalf of the deceased, a man referred to as Papa Ioannes from Sinnuris,

Text, translation and commentary available at:

https://www.academia.edu/33861876/_A_New_Coptic_Epitaph_from_the_Petrie_Museum_of_Egyptian_Archaeology._Bulletin_of_the_American_Society_of_Papyrologists_53_2016_223-232_with_Lincoln_H._Blumell_
title: Pediatric acute mastoiditis – our experience
Creators: name: Shrestha, Inku
name: Pokharel, Monika
name: Dhakal, Ashish
name: Amatya, Ram Chaya Man
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Acute mastoiditis (AM) is a leading intra-temporal complication of Acute Otitis Media (AOM) that most commonly occurs in young children. Occasionally, it presents as first sign of an ear disease. We aimed to evaluate its clinical course and determine therapeutic options for pediatric patients.[for full text, please go to the a.m. URL]
description: 88. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie
sj-pdf-3-tar-10.1177_1753466621995040 – Supplemental material for Burden of pulmonary arterial hypertension in England: retrospective HES database analysis
Creators: name: Exposto, Fernando
name: Hermans, Ruben
name: Nordgren, Åsa
name: Taylor, Luke
name: Rehman, Sanam Sikander
name: Ogley, Robert
name: Davies, Evan
name: Yesufu-Udechuku, Amina
name: Beaudet, Amélie
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-pdf-3-tar-10.1177_1753466621995040 for Burden of pulmonary arterial hypertension in England: retrospective HES database analysis by Fernando Exposto, Ruben Hermans, Åsa Nordgren, Luke Taylor, Sanam Sikander Rehman, Robert Ogley, Evan Davies, Amina Yesufu-Udechuku and Amélie Beaudet in Therapeutic Advances in Respiratory Disease
title: Adenoidectomy and myringotomy in the management of otitis media in children
Creators: name: Shukurov, Davron
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: In children adenoid hypertrophy (AH) and otitis media with effusion (OME) are consider one of the most common ENT pathologies. Usually, AH can cause nasal blockage, sinusitis and OME with some hearing loss (HL). In children AH and OME must be examined and diagnosed in early stages in order to prevent[for full text, please go to the a.m. URL]
description: 88. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie
title: Leitlinien-gemäße Standardisierung und Prozessmanagement der Cochlea-Implant-Versorgung
Creators: name: Stöver, Timo
name: Leinung, Martin
name: Helbig, Silke
name: Baumann, Uwe
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Cochlea-Implantat Versorgung stellt heute die Standardversorgung hochgradig Schwerhöriger bzw. tauber Patienten dar. Insbesondere in einem großen Cochlea-Implantat-Zentrum besteht die Notwendigkeit zur standardisierten Diagnostik, Beratung, Behandlung und Nachsorge betroffener[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 88. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie
Las asambleas comunitarias y la rendición de cuentas del Comité del Agua en San Nicolás, San Pablo del Monte, Tlaxcala (2024)
Creators: name: Gerónimo Castillo, Fabián Alejandro
name: Amaro Zahuantitla, Gustavo
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 440709
subject: Public policy
classificationCode: 441003
subject: Rural sociology
classificationCode: 440803
subject: Comparative government and politics
classificationCode: 350714
subject: Public sector organisation and management

description: La rendición de cuentas se posiciona como una de las principales demondas de las naciones, para lograr la confianza en la democracia y es necesaria para disminuir los delitos de corrupción y las prácticas de impunidad. En esta investigación se vinclua el marco jurídico de las presidencias de comunidad en el estado de Tlaxcala, para comprender la importancia de este cuarto orden de gobierno y su capacidad para gestionar los problemas públicos y para organizar a los habitantes en torno a prácticas que fortalecen (o aminoran) el tejido social; posteriormente, se aborda el proceso de organización de las asambleas comunitarias del caso presnetado, haciendo énfasis en la organización comunitaria y los actores involucrados. Finalmente, se reflexiona en torno a la importancia social de la rendición de cuentas de los comités de gestión de un bien de uso común tan preciado, como el agua en esta comunidad.
E06820: Coptic manuscript from the monastery of the Archangel Michael near Hamouli in the Fayum, relating the elevated status and function of *Michael, the Archangel (S00181); most likely written during the 6th century. Skeleton entry
Creators: name: Gschenke
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: Pierpont Morgan Codex M593 (folios 1r– 30v = pages 1–60)

The text begins with Jesus instructing his disciples on the creation of the world. They are asking him questions, and he explains the order of events to them. He relates in what order the angles were created, beginning with the first angel Saklataboth. The second angel created was Michael, the third Gabriel and the fourth Raphael.
After the creation of Adam, Jesus claims that the archangel Saklataboth refused to honour God's creation, Adam. As a result, God chose Michael to replace Saklataboth as the new head of the archangels.

Available at:

https://suciualin.files.wordpress.com/2016/11/the-investiture-of-michael-the-archangel.pdf

We have not examined this text.
Additional file 1 of Association of frailty status with overall survival in elderly hypertensive patients: based on the Chinese Longitudinal Healthy Longevity Survey
Creators: name: Li, Liying
name: Liang, Yueting
name: Xin, Dajun
name: Liu, Lu
name: Tan, Zhuomin
name: Wang, Ziqiong
name: Zhang, Muxin
name: Ruan, Haiyan
name: Zhao, Liming
name: Wang, Kexin
name: Zheng, Yi
name: Song, Ningying
name: He, Sen
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Mental Health

description: Supplementary Material 1.
Anti-breast cancer potential of thieno-pyrimidine derivatives as VEGFR-2 inhibitors
Creators: name: Alsfouk, Aisha A.
name: Al Ward, Maged Mohammed Saleh
name: Al-Qadhi, Mustafa A.
name: El-Metwally, Souad A.
name: Yousef, Reda G.
name: Elkaeed, Eslam B.
name: Husein, Dalal Z.
name: Amin, Fatma G.
name: Elkady, Hazem
name: Metwaly, Ahmed M.
name: Eissa, Ibrahim H.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Biochemistry
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Developmental Biology
Cancer
Hematology

description: Thieno-pyrimidine derivatives have emerged as promising candidates for VEGFR-2 inhibition. This study aimed to design, synthesize, and evaluate novel thieno-pyrimidine derivatives for their anti-cancer potential. A series of thieno-pyrimidine compounds were synthesized and screened for in vitro cytotoxicity against MDA-231 and MCF-7 cell lines. The most active compound, 6b, was further analyzed for VEGFR-2 kinase inhibition, wound healing, apoptosis induction, and cell cycle arrest. Molecular docking, 200 ns molecular dynamics simulations, MM-GBSA, ProLIF PCAT, and FEL analyses were conducted to assess binding stability. DFT calculations evaluated electronic properties, while in silico ADMET profiling predicted pharmacokinetics and toxicity. Compound 6b exhibited potent cytotoxicity with IC50 values of 5.91 µM (MDA-231) and 7.16 µM (MCF-7). It demonstrated VEGFR-2 inhibition is comparable to sorafenib (IC50: 53.63 ± 3.14 nM). Wound healing assays showed significant inhibition of MDA-231 migration. Flow cytometry confirmed apoptosis induction (57.20% early apoptosis) and G1 phase arrest. Gene expression analysis revealed upregulation of pro-apoptotic markers and downregulation of Bcl-2. Computational studies confirmed stable VEGFR-2 binding, and ADMET predictions indicated a favorable safety profile. Compound 6b exhibits strong VEGFR-2 inhibition, potent anti-cancer effects, and a favorable toxicity profile, highlighting its potential for further therapeutic development.
Inspired biomimetic design for efficient fluid channel configuration based on leaf vein structures
Creators: name: Chai, Shitong
name: Mei, Xiaokang
name: Xie, Yingxi
name: Lu, Longsheng
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Efficiency of heat and mass transfer is critical for vapor chambers (VCs), but conventional designs often encounter problems with heat transfer and liquid distribution. The hierarchical branch network and heat dissipation function of leaf veins share certain similarities with the wick structure employed in vapor chambers (VCs). Therefore, to explore the potential of biomimetic design for optimizing fluid channel configuration, we investigated the heat transfer and capillary flow performance of symmetric and asymmetric leaf vein (SLV and ALV) networks. Our investigation reveals that the SLV exhibits the best heat transfer and flow characteristics among the ALV and tree branch structure. Additionally, the relationship between the distribution patterns and natural structures of leaf veins was also elucidated. Our findings suggest that the leaf vein network may offer a promising template for designing more efficient liquid channels in VCs and other engineering applications.
Spirocyclic compounds: potential drug leads in the fight against Mycobacterium tuberculosis
Creators: name: Kumar, Pardeep
name: Singampalli, Anuradha
name: Bandela, Rani
name: Srimounika, Bellapukonda
name: Rajyalakshmi, Sugali Indravath
name: Devi, Ankita
name: Nanduri, Srinivas
name: Madhavi, Yaddanapudi Venkata
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: TB drug discovery needs scientists’ attention since drug resistance in TB, including extensively drug-resistant TB (XDR-TB) and multidrug-resistant TB (MDR-TB), is a major healthcare concern. Since millions of fatalities from tuberculosis are recorded each year, there is an urgent need to discover new anti-tubercular medications that will either eradicate or control the disease. Spiro compounds have garnered a lot of attention in medicinal chemistry these days because of various biological activities mainly because of their adaptability and structural resemblance to significant pharmacophores. This article overviews the synthesis and activity of spirocyclic compounds as anti-tubercular agents. Both synthesized and naturally occurring spiro chemicals exhibit antitubercular properties. The promising antitubercular potential shown by some of the spirocyclic compounds has attracted scientists to explore them further to develop molecules with improved pharmacodynamic and pharmacokinetic properties and new mechanisms of action with enhanced safety and efficacy in tuberculosis. The current review covers the exploration of spiro compounds from the year 2004 to 2024 for the combat of Tuberculosis. This review gives the comprehensive advancements in this scaffold which would help the logical design of powerful, less toxic, and more effective spirocyclic anti-TB medicinal molecules.
Synthesis, in vitro and in-silico evaluation of amide derivatives as prospective antimicrobial and antileishmanial agents
Creators: name: Rashid, Haroon Ur
name: Khan, Sher Wali
name: Latif, Abdul
name: Nayab, Saira
name: Umar, Muhammad Naveed
name: Sana, Fatima
name: Shah, Abdul Bari
name: Zahoor, Muhammad
name: Ullah, Riaz
name: Ali, Essam A
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: This study focused on the synthesis, antimicrobial, and antileishmanial evaluation of seven amide derivatives (AL-1 to AL-7). The target compounds were synthesized from L-cysteine methyl ester and various substituted aromatic and aliphatic carboxylic acids. The final products were characterized using physical and spectro-analytical techniques (FT-IR, 1H NMR). The derivatives were evaluated for their antimicrobial activity at various concentrations. Experimental studies revealed that compounds AL-5 and AL-6 were the most potent against Staphylococcus aureus and Escherichia coli, exhibiting 18 mm and 21 mm inhibition zones, respectively, at a concentration of 2000 µg/mL. Additionally, AL-5 and AL-6 showed significant activity against Candida albicans, with 20 mm and 23 mm inhibition zones, respectively, at a concentration of 1000 µg/mL. The compounds also exhibited moderate to good activity against Leishmania tropica. Compounds AL-2, AL-4, AL-5, and AL-6 demonstrated good activity, with IC50 values of 0.68 ± 0.09, 0.68 ± 0.16, 0.66 ± 0.08, and 0.68 ± 0.12 µg/mL, respectively. Molecular docking, in silico Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) analysis, and Density Functional Theory (DFT) studies were conducted on the most potent compounds (AL-5 and AL-6) to validate and support their experimental antimicrobial and antileishmanial potential.
E06821: Coptic manuscript from the monastery of the Archangel Michael near Hamouli in the Fayum, relating the status and function of *Gabriel, the Archangel (S00192); most likely written during the 6th century. Skeleton entry
Creators: name: Gschenke
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: Pierpont Morgan Codex M593 (folios 31r– 50r = pages 61–100)

In this text Jesus answers questions of his disciples concerning the division of everything in the world, from the aeons of light to the animals created, as well as about the number of angels and their order. Gabriel's status, appointed by God as the messenger of life to serve and comfort anyone in affliction, is being discussed.

Available at:

https://suciualin.files.wordpress.com/2017/05/jenott-investiture-of-archangel-gabriel.pdf

We have not examined this text.
Inspired biomimetic design for efficient fluid channel configuration based on leaf vein structures
Creators: name: Chai, Shitong
name: Mei, Xiaokang
name: Xie, Yingxi
name: Lu, Longsheng
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Efficiency of heat and mass transfer is critical for vapor chambers (VCs), but conventional designs often encounter problems with heat transfer and liquid distribution. The hierarchical branch network and heat dissipation function of leaf veins share certain similarities with the wick structure employed in vapor chambers (VCs). Therefore, to explore the potential of biomimetic design for optimizing fluid channel configuration, we investigated the heat transfer and capillary flow performance of symmetric and asymmetric leaf vein (SLV and ALV) networks. Our investigation reveals that the SLV exhibits the best heat transfer and flow characteristics among the ALV and tree branch structure. Additionally, the relationship between the distribution patterns and natural structures of leaf veins was also elucidated. Our findings suggest that the leaf vein network may offer a promising template for designing more efficient liquid channels in VCs and other engineering applications.
Estudio de los enfoques de aprendizaje en cuatro cohortes de estudiantes de Agronomía de la Universidad Central del Ecuador.
Creators: name: Torres, Ronald
Publisher: name: Humanities Commons
Year: 2023

description: Se dice que en los años 60 y 70 han optado por el enfoque de aprendizaje profundo que tiene como características al ver la forma de lo aprendido mediante los saberes de los estudiantes , un grado alto de interés que solo piensa en saber mediante lo aprendido y sobre salir en sus estudios ; seguido de cerca del enfoque de aprendizaje superficial donde toman a todo la  finalidad de aprender con tan solo memorizarse  y la finalidad es  solo pensar  en poder graduarse sin ver notas altas con tal de pasar las materias , finalmente se encuentran los estudiantes que tan solo se enfocan en aprender mediante clases sin dar ninguna señal de aprendizaje y solo observar y verificar los resultados de ellos sin estudiar .
Estudio de los enfoques de aprendizaje en cuatro cohortes de estudiantes de Agronomía de la Universidad Central del Ecuador.
Creators: name: Torres, Ronald
Publisher: name: unknown
Year: 2023

description: Se dice que en los años 60 y 70 han optado por el enfoque de aprendizaje profundo que tiene como características al ver la forma de lo aprendido mediante los saberes de los estudiantes , un grado alto de interés que solo piensa en saber mediante lo aprendido y sobre salir en sus estudios ; seguido de cerca del enfoque de aprendizaje superficial donde toman a todo la finalidad de aprender con tan solo memorizarse y la finalidad es solo pensar en poder graduarse sin ver notas altas con tal de pasar las materias , finalmente se encuentran los estudiantes que tan solo se enfocan en aprender mediante clases sin dar ninguna señal de aprendizaje y solo observar y verificar los resultados de ellos sin estudiar .
Additional file 1 of Toxicity of external beam accelerated partial-breast irradiation (APBI) in adjuvant therapy of early-stage breast cancer: prospective randomized study
Creators: name: Burkon, Petr
name: Selingerova, Iveta
name: Slavik, Marek
name: Holanek, Milos
name: Vrzal, Miroslav
name: Coufal, Oldrich
name: Polachova, Katerina
name: Muller, Petr
name: Slampa, Pavel
name: Kazda, Tomas
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: Supplement Material 1. Supplementary Table 1: Dose constraints and plan optimization. Supplementary Figure 1: Dose distribution and beam arrangement for APBI arm
Estudio de los enfoques de aprendizaje en cuatro cohortes de estudiantes de Agronomía de la Universidad Central del Ecuador
Creators: name: Rivaldo Cachimuel Pachito, Everson
Publisher: name: unknown
Year: 2023

description: mención del tipo de enfoque de estudio que presentan los estudiantes de la Facultad de Ciencias Agrícolas de la Universidad Central del Ecuador