cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Spatial epidemiology and the psychosocial impacts of lymphatic filariasis in Nigeria
Creators: name: Eneanya, Obiora Augustine
Publisher: name: Imperial College London
Year: 2019

description: Nigeria’s National Programme to Eliminate Lymphatic Filariasis has concluded mapping to identify endemic districts, based on a binary classification of endemic or non-endemic. Although this is useful for the planning of control programmes, it does not portray heterogeneities of infection level that may exist within districts. Entire populations in endemic districts are targeted with chemotherapy which aims to treating and prevent new infections. For populations with advanced stages of disease, such as lymphedema and hydrocele, palliative care is given to alleviate suffering. Work done in this thesis described the ecology of lymphatic filariasis, mapping the geographical and environmental limits of infection in Nigeria. Here, climate, environmental and demographic factors and their influence on infection was investigated. To refine prevalence estimates, machine learning models have been used to map the distribution of lymphatic filariasis, predicting infection level for previously unsurveyed areas. Maps presented here uncover the spatial heterogeneity of prevalence levels that exists within districts. A field survey was also conducted to pilot a patient search strategy for estimating patient numbers and classifying their stage and degree of morbidity. Here the psychosocial and economic impacts of LF morbidity was characterized in a typical endemic rural setting. Overall, this thesis describes the ecological niche of lymphatic filariasis (LF) in Nigeria and provides an estimate of the population living in areas that are environmentally suitable for disease transmission. Work presented in Chapter 3 provides baseline prevalence estimates at country level as well as subnational estimates. A field survey aimed at estimating the burden and classifying the degree of morbidity within communities gave insights into methods for identifying chronic LF patients in rural communities and priorities for care. Findings demonstrate that patients are at high risk of mental health problems. Here we have suggested alternative strategies to deliver morbidity care at the community level. For the implementation of the mass drug administration programme, there is need for robust estimates of infection level. Prevalence levels are also a key benchmark for monitoring the progress of interventions and assessing the feasibility driving down infection thresholds, thus achieving elimination targets. For morbidity management programmes, robust estimates of patient numbers are essential for planning of care delivery strategies. In prioritizing morbidity care, characterising patient needs is important to maximizing programme efforts.
CCWI2017: F47 'ONE-CLASS SVM – LEAK DETECTION IN WATER DISTRIBUTION SYSTEMS'
Creators: name: Cody, Roya
name: Sriram Narasimhan
name: Tolson, Bryan
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Acoustic leak detection in water distributions systems has been reviewed and validated for decades in various laboratory and field settings. However, the existing systems rely heavily on detailed knowledge of the pipe system, an assumption of ideal conditions, as well as direct access to infrastructure pipelines. This paper presents an experimental investigation that addresses the need of minimally invasive water distribution monitoring in cold climates. Monitoring in cold climates is achieved with a permanent dry barrel hydrant mounted passive sensor system. The sensor system sits within the water column while still being accessible via the hydrant. Lab tests utilize a retrofitted hydrant and pipe system. Experiments show the effectiveness of using fire hydrant mounted sensors in leak detection. Acoustic signals due to simulated leaks are measured, and a one-class support vector machine (OCSVM) classification methodology is applied. Results showed that a simulated leak can be detected with a 97% classification accuracy.
Performance art in the context of the special collections and digital archives at Academy of Art and Design FHNW: Remarks on questions of access and reuse
Creators: name: Lurk, Tabea
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2021
Subjects: subject: Open Access
subject: NFT
subject: Licensing
subject: Performance Art
subject: Collection
subject: 020 - Bibliotheks- und Informationswissenschaft

description: The talk will introduce the performance art collections at Mediathek HGK FHNW. In doing so, the connection between collecting and enabling culture becomes clear. Then Creative Commens licenses are shortly introduced, because in the academic environment it is common practice to make content freely accessible. The samples will underline the relevance of openness, access and re-use in the specific context of performance art. Finally, a connection to the topics of the conference is presented, by addressing the already mentioned NFT-technology (non-fungible token). The talk considers to what extent blockchain technologies can contribute to an understanding where the free flow of open, artistic content/objects can coexist with a specific type of exclusivity, authenticity, scarcity as it is incorporated in the art market.
The role of bile-metabolising enzymes in the pathogenesis of Clostridioides difficile infection, and the impact of faecal microbiota transplantation
Creators: name: Mullish, Benjamin Harvey
Publisher: name: Imperial College London
Year: 2019

description: The pathogenesis of Clostridioides difficile infection (CDI), and mechanisms of efficacy of faecal microbiota transplant (FMT) in treating recurrent CDI (rCDI), remain poorly-understood. Certain bile acids affect the ability of C. difficile to undergo germination or vegetative growth. Loss of gut microbiota-derived bile-metabolising enzymes may predispose to CDI via perturbation of bile metabolism, and restitution of gut bile-metabolising functionality could mediate FMT’s efficacy. Initially, human samples were analysed, i.e.: 1) biofluids collected from rCDI patients pre- and post-FMT (and their donors), and 2) stool samples from primary CDI patients, including both recurrers and non-recurrers. Analysis included: 16S rRNA gene sequencing; liquid chromatography-mass spectrometry for bile acid profiling; gas chromatography-mass spectrometry for short chain fatty acid (SCFA) quantification; bile salt hydrolase (BSH) enzyme activity; and qPCR of bsh/ baiCD genes involved in bile metabolism. Human results were validated in C. difficile batch cultures and a rCDI mouse model. A reduced proportion of the stool microbiota of rCDI patients pre-FMT contained BSH-producing bacteria compared to donors or post-FMT. Pre-FMT stool was enriched in taurocholic acid (TCA; a potent trigger to C. difficile germination); TCA levels negatively correlated with bacterial genera containing BSH-producing organisms. Post-FMT stool demonstrated recovered BSH activity and microbial bsh/ baiCD gene copy number compared with pre-treatment (p<0.05), and recovery of SCFA including valerate (p<0.001). Dynamics of stool bile acids/ BSH activity differed in primary CDI patients with and without disease recurrence. In batch cultures, culture supernatant from engineered bsh-expressing E. coli reduced TCA-mediated C. difficile germination relative to supernatant from BSH-negative E. coli. C. difficile total viable counts were ~70% reduced in a rCDI mouse model after administration of BSH-expressing E. coli relative to mice receiving BSH-negative E. coli (p<0.05). These data demonstrate that gut microbiota BSH functionality is a key mechanism influencing vulnerability to CDI and efficacy of FMT.
Agiles Arbeiten – Konfliktmanagement und Gesundheit
Creators: name: Vollmer, Albert
name: Vetter, Ariane
Publisher: name: Gesundheitsförderung Schweiz
Year: 2021
Subjects: Agilität
Konflikte
Gesundheit
Konfliktmanagement

description: Konflikte gehören in agilen Teams zum Alltag. Sie zu bearbeiten fällt mit zunehmender Selbstorganisation in den Verantwortungsbereich der Teammitglieder. Hier wird dargelegt, welche Konfliktpotenziale in agilen Teams vorhanden sind und wie sich diese auf die psychische Gesundheit auswirken. Es wird aufgezeigt, wel­che Voraussetzungen und Prozesse auf Teamebene sowie welche Rahmenbedingungen auf der Ebene der Organisation einer konstruktiven Konfliktbearbeitung dienlich sind. Hierfür werden jeweils praktische Mass­nahmen abgeleitet. Ein proaktives Konfliktmanagement dient dem Gelingen der Zusammenarbeit und der Entwicklung von Mensch und Organisation.
CCWI2017: F79 'Identifiability analysis for pressure sensors positioning'
Creators: name: Puleo, Valeria
name: Tarantino, Silvia
name: Freni, Gabriele
name: Loggia, Goffredo La
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: The identifiability analysis is investigated as sampling design method aimed to the leakage detection in looped water distribution networks. The preliminary ranking of the candidate nodes for the pressure sensors positioning is performed by running several hydraulic simulations and calculating sensitivity functions. The reduced subset of nodes and their sensitivities are then used to perform the identifiability analysis by calculating the collinearity index which provides the maximum number of sensors and their location into the network. The index selects the nodes according to their sensitivities to several leakages scenarios, simulated in EPANET by changing the emitter coefficient of the leakages function both with a One-At-Time and Monte Carlo approach. The collinearity index also identifies the subset of the pressure monitoring nodes with the lowest correlation (redundancy) between the measurements. The method is applied to the benchmark network Apulian.
CCWI2017: F144 'Design of an Observational Study for Investigating the Impact of Pressure Transients on Pipe Failures in Water Supply Networks'
Creators: name: Rezaei, Hossein
name: Stoianov, Ivan
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: A system-wide investigation into the impact of quasi-steady and unsteady state pressure variations on the structural degradation and ultimate failure of pipes is critical for prioritising operational and capital expenditures. Such investigations rely upon an optimally designed observational study and the availability of metrics, which accurately capture the physical phenomena. The objective of this paper is to explore advances in causal inference and statistical methods in order to develop a sampling survey methodology that is required to differentiate the impact of pressure variations and transients, and other causal factors on pipe deterioration and failures.
Towards Governance for Open Urban Food Futures
Creators: name: Hee-Jeong Choi, Jaz
name: Heitlinger, Sara
name: Taylor, Alex
name: Bedö, Viktor
Publisher: name: Routledge
Year: 2022
Subjects: subject: food systems
subject: commons
subject: food justice
subject: 700 - Künste und Unterhaltung

description: Current global crises, including natural disasters, pandemic, and political cataclysms, are exacerbating intolerable living conditions for the majority. This chapter examines potentials and perils in the uneven terrains of the current food systems. It problematises the current design and maintenance of food systems driven by technocapitalist agendas, and highlights the need to interject new structures and processes for governance. Drawing from emerging calls for open, commons-based urban food futures, the chapter discusses why urban food governance must focus on the process of relating multiple, always changing aspects of food. Here, questioning and imagining diverse futures is critical. This chapter suggests two ways to achieve this: 1) repairing and repurposing current closed systems to become more open, and 2) building capacity in learning to cope with complex relational conditions bringing with them uncertainties, differences, and emergence of the new. The chapter argues that transdisciplinary and creative practices must become an inherent part of building food futures, urban and otherwise, as a means of imagining and raising questions, rather than solving predefined or assumed problems, thereby creating spaces for new forms of governance to emerge, based on equity, justice, and pluralism.
Agroecology Principles in Aquaculture: A Case Study of East Africa
Creators: name: David Pokupec1
name: Tina Lešnik1
name: Andreja Borec1
Publisher: name: Zenodo
Year: 2024
Subjects: agroecology
east africa
farming practices
integrated aqua agriculture

description: Agroecology Principles in Aquaculture: A Case Study of East Africa - the abstract addresses the growing recognition of Agroecology as a potent instrument for enhancing food security, environmental conservation, and climate resilience in East Africa, supported by research, policy, and economic incentives. The abstract further underscores the potential of Integrated Aqua-Agriculture as a promising practice for agroecological transition.
Komplett in den Wolken
Creators: name: Gatziu Grivas, Stella
name: Giovanoli, Claudio
name: Grand, Shanti
Publisher: name: Swiss Professional Media
Year: 2016
Subjects: subject: Cloud-Lösungen
subject: Cloud-Einsatz
subject: integriertes Benchmarking
subject: 330 - Wirtschaft

description: Die Cloud-Studie der FHNW führt das neue «Cloud Maturity Model» in der Schweiz ein. Dieses erlaubt Schlussfolgerungen bezüglich Auswirkungen des Einsatzes von Cloud-Technologien auf die Unternehmens-IT.
Additional file 8 of Integrated CNV-seq, karyotyping and SNP-array analyses for effective prenatal diagnosis of chromosomal mosaicism
Creators: name: Ma, Na
name: Xi, Hui
name: Chen, Jing
name: Peng, Ying
name: Jia, Zhengjun
name: Yang, Shuting
name: Hu, Jiancheng
name: Pang, Jialun
name: Zhang, Yanan
name: Hu, Rong
name: Wang, Hua
name: Liu, Jing
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Additional file 8. Figure S7: Case 67. Mosaic trisomy 21 and mosaic duplication of Xp11.21q28 detected CMA and CNV-Seq. Panel A. CMA result. Panel B. CNV-Seq result. Blue lines on sequencing plots represent mean copy number changes. Panel C. Karyotype showing trisomy 21 and XXX. Positions of CNVs are indicated by the dashed boxes.
The role of asymmetric dimethylarginine in murine pregnancy and its link to pregnancy-induced hypertension
Creators: name: Georgopoulou, Aikaterini
Publisher: name: Imperial College London
Year: 2018

description: Globally, preeclampsia accounts for approximately 10% of pregnancy-related deaths. In the United States, the incidence of the disease has risen dramatically over the last two decades. Pharmacological interventions for the management of preeclampsia are very limited; premature delivery is the only option, often resulting in life-long disabilities. Association studies indicate increased levels of asymmetric dimethylarginine (ADMA) in preeclamptic patients, prior to clinical manifestation. ADMA is a negative regulator of the nitric oxide signaling pathway with high levels leading to systemic hypertension in vivo. Inhibition of the enzyme dimethylarginine dimethylaminohydrolase (DDAH) leads to accumulation of ADMA, suggesting that the latter is actively metabolized by DDAH. We sought to assess the impact of elevated ADMA levels on haemodynamic adaptations during pregnancy and fetoplacental development in vivo through genetic DDAH1 manipulation. Clinical studies have shown that paternal genes increase preeclampsia susceptibility. We hypothesised that a systemic increase in maternal AMDA would lead to a hypertensive response during gestation, mediated by the fetus. In order to test the above hypothesis, two distinct mouse models were generated; a DDAH1 null model and a fetal-specific DDAH1 knockout model. DDAH1 deletion led to accumulation of plasma ADMA, sFlt-1 and sEng during late gestation accompanied by a significant increase in systemic blood pressure. Fetal-specific DDAH1 deletion led to a small but significant increase in maternal circulating ADMA and elevated blood pressure around parturition. Given the above findings, we hypothesized that paternally- inherited single nucleotide polymorphisms (SNPs) with the ddah1 locus might alter the susceptibility to preeclampsia. To test this hypothesis, the frequency of several SNPs was estimated and compared between babies from preeclamptic and normotensive pregnancies. No correlation was identified for any of the variants analysed, suggesting that paternal DDAH1 does not alter the risk of preeclampsia. It is worth mentioning that the analysis was done in a small cohort; as such, additional studies are needed in order to draw safe conclusions.
MPA Europe Deliverable 2.5 Depth-integrated marine ecosystem classification for Europe
Creators: name: Campoy, Ana
name: Assis, Jorge
name: Addamo, Anna Maria
name: Zhao, Qianshuo
name: Costello, Mark John
Publisher: name: Zenodo
Year: 2024

description: Disclaimer: This is document is part of a deliverable not yet approved by the European Commission. The present document reports the Deliverable 2.5 of MPA Europe. This report details the data acquisition and computational procedures involved in Deliverable 2.5 of MPA Europe. It provides a depth-integrated marine ecosystem classification for Europe (0-2,500 m depth) using a wide range of spatially complete and standardised environmental data that reflect both ecosystem conditions and functioning.
Additional file 5 of Integrated CNV-seq, karyotyping and SNP-array analyses for effective prenatal diagnosis of chromosomal mosaicism
Creators: name: Ma, Na
name: Xi, Hui
name: Chen, Jing
name: Peng, Ying
name: Jia, Zhengjun
name: Yang, Shuting
name: Hu, Jiancheng
name: Pang, Jialun
name: Zhang, Yanan
name: Hu, Rong
name: Wang, Hua
name: Liu, Jing
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Additional file 5. Figure S4: Case 64. Chromosomal mosaicism for Xp2.33q21.31 detected by CMA and CNV-Seq. Panel A. CMA result. Panel B. CNV-Seq result. Blue lines on sequencing plots represent mean copy number changes. Panel C. Karyotype showing Xp deletion.
Calvin Albert, Sculptor, William Tarr, and Doris Lermon at Artist Member's Exhibition, 1978
Creators: name: (:Unas)
Publisher: name: Unknown
Year: 1978
Subjects: East Hampton
Art exhibitions
Painting
Exhibitions
Artists

description: This image taken by Philippe Montant shows Calvin Albert, Sculptor, William Tarr, and Doris Lermon at Artist Member's Exhibition, 1978.
CCWI2017: F26 'Understanding the Range of Influence of Moderate-Sized and Short- Duration Transients in Water Distribution Systems'
Creators: name: Stephens, Mark
name: Marchi, Angela
name: Jinzhe Gong
name: Lambert, Martin
name: Leonard, Michael
name: Simpson, Angus
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: While extreme pressure transients are widely understood, moderate and frequent transients are not frequently studied. This paper reports on field results from the Central Business District (CBD) of Adelaide, South Australia, which show that moderate transients are caused by regular and semi- regular events. The results are analysed to assess the range of influence (and impact) of these events and are also compared to the results from transient hydraulic models. The use of the model predictions, with relative adjustment for measured damping, can be used to estimate the number of events that could be detected based on the number of time-synchronised high frequency loggers and their location.
Additional file 6 of Integrated CNV-seq, karyotyping and SNP-array analyses for effective prenatal diagnosis of chromosomal mosaicism
Creators: name: Ma, Na
name: Xi, Hui
name: Chen, Jing
name: Peng, Ying
name: Jia, Zhengjun
name: Yang, Shuting
name: Hu, Jiancheng
name: Pang, Jialun
name: Zhang, Yanan
name: Hu, Rong
name: Wang, Hua
name: Liu, Jing
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Additional file 6. Figure S5: Case 65. Mosaic duplication of Yq11.222q11.223 detected by CMA and CNV-Seq. Panel A. CMA result. Panel B. CNV-Seq result. Blue lines on sequencing plots represent mean copy number changes. Panel C. Karyotype showing Yq duplication. Positions of CNVs are indicated by the dashed boxes.
Development of fluorogenic RNA aptamers for cellular imaging of RNA and genomic loci
Creators: name: Cawte, Adam David
Publisher: name: Imperial College London
Year: 2018

description: In recent years, there has been an explosion of SELEX-evolved fluorescent RNA aptamers, such as Spinach, Broccoli, Corn and Mango. Fluorogenic RNA aptamers have sparked a lot of interest and hold great potential to enable background-free visualisation of RNA molecules in cellular environments. However, their application has been limited by relatively inefficient folding in vivo and fluorescent stability. Therefore, evolving new RNA aptamers with improved brightness and stability should better their use in cellular imaging. Three new Mango-based aptamers have recently been selected from the original Mango RNA SELEX pool using microfluidic- assisted in vitro compartmentalization and fluorescence-activated sorting. This thesis demonstrates the use of these new aptamer variants to image small non-coding RNAs (such as 5S rRNA, U6 snRNA and mgU2-47 scaRNA) in both fixed and live human cells with improved sensitivity and resolution. Upon expression the modified RNAs subcellular localisation pattern is conserved, as validated using immunofluoresence. Recent work with tandem Mango arrays shows increased sensitivity, which enables the visualization of single mRNA molecules in live and fixed cells. Furthermore, it is shown that the tandem Mango arrays don’t affect the expected localization of a cytoplasmic mRNA (β-actin) and the nuclear long non- coding RNA (NEAT-1). Furthermore, these RNA aptamers can also be used to label genomic loci via CRISPR/Cas9 mediated genome targeting with improved contrast. This allows for the targeting of short genomic repeats in a less invasive manner with regards to current methodologies. Taken together this data shows that new Mango aptamers are vastly improved for cellular imaging over previous RNA aptamers, and can in principle be incorporated into a wide range of coding and non-coding RNAs.
CCWI2017: F9 'Agent-based Modeling as a Decision Support Tool for Water Conservation Planning'
Creators: name: Tourigny A
name: Y, Filion
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: The paper presents a simulation approach to model water conservation campaigns by coupling agent-based and hydraulic models. The approach is unique as it incorporates modeling the communication strategies that can be used to promote water reduction measures. An illustrative case study is developed where households, represented as agents, are targeted through a mail-in and social media campaign that prompts them to consider adopting rain barrels. The water demands before and after the rain barrel campaign are evaluated through the EPANET2.0 hydraulic network solver in order to calculate the change in energy use stemming from the measures. The study found that 1.51 ML of water a day could be saved through the campaign however it would take 18 years to reach the adoption target using the proposed communication strategy.
A prospective longitudinal study of maternal cardiovascular function from pre-conception to post-partum: the CONCEIVE Study
Creators: name: Foo, Fung Lin
Publisher: name: Imperial College London
Year: 2019

description: Pre-eclampsia (PE) and fetal growth restriction (FGR) confer higher risk of later life maternal cardiovascular disease. It is unclear whether pre-existing inert cardiovascular dysfunction manifests as PE/FGR during pregnancy, or whether PE/FGR attribute an independent risk that augments cardiovascular disease with age. To clarify, subjects should be studied pre-conception, providing cardiovascular observations that are independent of pregnancy- or disease induced physiological changes. A pilot study (IMPOST) demonstrated the feasibility of investigating pre-conception cardiovascular function. CONCEIVE, on which this thesis is based, follows a similar protocol, but is powered to detect differences in cardiac output, reportedly abnormal in PE/FGR pregnancies102-104, 110. Protocol additions of ovulation/implantation tracking provided an opportunity to observe peri-conceptional events with spontaneous conceptions. Further, pre-pregnancy exercise stress-testing, hypothesised to mimic the physiological stress of pregnancy, was performed. The primary objective was to assess associations between pre-pregnancy cardiovascular function and PE/FGR in subsequent pregnancy. Secondary objectives were to investigate longitudinal trajectories of cardiovascular function and exercise testing in relation to PE/FGR, and peri-conceptional hormonal changes in relation to pregnancy viability. 387 healthy participants were recruited into the study. Cardiovascular assessments were performed pre-conception, through pregnancy (6, 10, 22 and 34 gestational weeks) and post-partum. Early pregnancy hormonal changes were tracked with a digital fertility monitor. Outcomes of unaffected pregnancy, PE/FGR and pregnancy loss were recorded and correlated to study parameters. There were significant differences in pre-pregnancy haemodynamics, with a low-output/high-resistance state associated with PE/FGR in next pregnancy. Subjects who developed PE/FGR had significantly different responses to pre-pregnancy exercise testing. An optimal ovulation-implantation window is associated with first trimester viability, and early differences in hCG rise can distinguish between pregnancy viability outcomes. The study concludes that cardiovascular dysfunction prior to pregnancy is associated with risks of developing PE/FGR in a subsequent pregnancy. Larger prospective studies of this nature may facilitate identifying women at risk, and providing intervention to alter maternal haemodynamics to improve pregnancy outcomes, at a pre-clinical stage.
[Compaso] 12(2)_Obreja Dragoș.pdf
Creators: name: Obreja, Dragos
Publisher: name: figshare
Year: 2022
Subjects: subject: Sociology
subject: FOS: Sociology

description: The study of motives in sociology and new media is often debated in the digital environment. However, little has been written about the motives that encourage gamers to be active in the virtual environment, and even less about the subject of gaming during the Covid-19 pandemic. Thus, the objective of this study is to point out some of the motives (be they social, cultural or economical) why different players have opted for gaming in an environment full of pandemic-induced lockdowns. Thereby, 28 Romanian gamers were selected from Youtube pages of a few streamers, to be interviewed twice: Once during the lockdown and once after the lockdown ended, obtaining a total of 56 interviews. Afterwards, a thematic analysis of the main identified motives was performed, which determined the identification of four main reasons in support of gaming: gaming as communicational environment, gaming as a “pandemic education” platform, gaming as nostalgia and gaming as acquiring new skills, each with its own characteristics. Even though some themes are present in the Covid-19 pandemic as they were in the past, there are new themes, such as gaming as a so-called "pandemic education", where the game appears rather as a civic consciousness. Also, the WHO initiative, #PlayApartTogether, seems to be an important incentive to identify recurring themes regarding gaming during lockdown.
A multi-criteria assessment strategy for 3D printed porous polyetheretherketone (PEEK) patient-specific implants for orbital wall reconstruction
Creators: name: Sharma, Neha
name: Welker, Dennis
name: Aghlmandi, Soheila
name: Maintz, Michaela
name: Zeilhofer, Hans-Florian
name: Honigmann, Philipp
name: Seifert, Thomas
name: Thieringer, Florian
Publisher: name: MDPI
Year: 2021
Subjects: Blow-out
Biocompatible materials
Computer-aided design
Finite element analysis
Orbit
Implant
Orbital fracture
Patient-specific modeling
Printing
Three-dimensional

description: Pure orbital blowout fractures occur within the confines of the internal orbital wall. Restoration of orbital form and volume is paramount to prevent functional and esthetic impairment. The anatomical peculiarity of the orbit has encouraged surgeons to develop implants with customized features to restore its architecture. This has resulted in worldwide clinical demand for patient-specific implants (PSIs) designed to fit precisely in the patient’s unique anatomy. Material extrusion or Fused filament fabrication (FFF) three-dimensional (3D) printing technology has enabled the fabrication of implant-grade polymers such as Polyetheretherketone (PEEK), paving the way for a more sophisticated generation of biomaterials. This study evaluates the FFF 3D printed PEEK orbital mesh customized implants with a metric considering the relevant design, biomechanical, and morphological parameters. The performance of the implants is studied as a function of varying thicknesses and porous design constructs through a finite element (FE) based computational model and a decision matrix based statistical approach. The maximum stress values achieved in our results predict the high durability of the implants, and the maximum deformation values were under one-tenth of a millimeter (mm) domain in all the implant profile configurations. The circular patterned implant (0.9 mm) had the best performance score. The study demonstrates that compounding multi-design computational analysis with 3D printing can be beneficial for the optimal restoration of the orbital floor.
CCWI2017: F140 'Management-Indicators Consulting System for Potable Water Utilities'
Creators: name: Martha Patricia Hansen, R.
name: José Manuel Rodríguez, V.
name: Yenni Laurel, V.
name: Horacio Fernández, G.
name: Gema Alín Martínez, O.
name: Edgar Antúnez, L.
name: Luis Gómez, L.
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: The service-quality performance that a water utility offers any city can be measured according to the efficiency and effectiveness with which it provides water, gathers it and treats it once it becomes wastewater. Other important aspects are, user satisfaction, the continuous provision of water with quality and quantity, knowledge of the elements that make up the infrastructure, having a reliable users' register; knowledge of production and delivery of water to consumers, use of all treatment units' full capacity. Not to mention, attention to users' complaints in a reasonable time and timely payment for the service as well as the repayment of operation costs, maintenance and administration. This is why it is important to create a system of indicators that permits the evaluation of the evolution of the development and modernization process of water utilities for potable water, sewerage and treatment, set goals to be reached, and contribute to the transparency of national information. The Mexican Water Technology Institute (IMTA, 2017), created an indicator program for the management of water utilities (PIGOO, based on its initials in Spanish) which have gone up from 50 to 189 since 2005 to 2016, they provide service to 49% of the population in Mexico. At the same time, the number of management indicators has gone from 12 to 29. Information is available for the 245 participating organisms on the web site, http://www.pigoo.gob.mx/, which has an option for consulting a mobile app for the Android operating system. The battery of 29 management indicators permits the measurement of the performance and efficiency of potable water systems in technical-operative, commercial and financial aspects. Ideally, performance indicators for water utilities would be linked to an objective or a strategy that the same entity sets. These are calculated through data gathered from annual reports of variables such as water volume produced, number of employees, total revenue and costs, occurrence of leaks, complaints etc. The website has, among other things, the possibility of comparing these indicators, geographic consulting, and search filters for different demographic and geographic ranges of value for different management-performance indicators. This work presents the diverse topics and options that the program offers as well as the analysis of its results.
Berufswunsch Lehrperson: FMS und Gymi – zwei Wege an die PH
Creators: name: Hafner, Sandra
Publisher: name: Aargauischer Lehrerinnen- und Lehrerverband (alv)
Year: 2020
Subjects: subject: Fachmittelschule
subject: Gymnasium
subject: Primarlehrer/innenbildung
subject: Bildungssoziologie
subject: Konventionensoziologie
subject: 370 - Erziehung, Schul- und Bildungswesen
subject: 300 - Sozialwissenschaften, Soziologie, Anthropologie

description: Viele angehende Primarlehrpersonen haben auf Sekundarstufe II entweder die FMS Pädagogik oder das musisch-pädagogische Profil des Gymnasiums besucht. Der Beitrag geht der Frage nach, worin sich die beiden Bildungswege unterscheiden.
CCWI2017: F138 'Modelling capital costs of sewer system assets'
Creators: name: Cabral, Marta
name: Pinheiro, Alexandre
name: Loureiro, Dália
name: Dídia Covas
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: The aim of this paper is the establishment of cost functions for the various assets of sewer systems, namely gravity and raising pipes, drainage and storm water pipes, service connections and pumping stations. Costs are defined as a function of the main physical characteristics of the assets, such as, pipe material and nominal diameter (for pipes and service connections) and flow rate, pump head and pump power (for pumping stations). A five-step methodology was followed: 1) data collection, processing and analysis, 2) present cost value calculation, 3) asset characterization and key parameters identification, 4) cost functions and prediction band estimation, and 5) cost functions validation. Cost and infrastructure data for construction contracts of wastewater systems managed by different Portuguese water and wastewater utilities were analysed. Cost functions were estimated based on multiple linear regression analysis.
Additional file 7 of Integrated CNV-seq, karyotyping and SNP-array analyses for effective prenatal diagnosis of chromosomal mosaicism
Creators: name: Ma, Na
name: Xi, Hui
name: Chen, Jing
name: Peng, Ying
name: Jia, Zhengjun
name: Yang, Shuting
name: Hu, Jiancheng
name: Pang, Jialun
name: Zhang, Yanan
name: Hu, Rong
name: Wang, Hua
name: Liu, Jing
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Additional file 7. Figure S6: Case 66. Mosaic deletion of Xp22.33p11.21 and Xq13.2q28 detected by CMA and CNV-Seq. Panel A. CMA result. Panel B. CNV-Seq result. Blue lines on sequencing plots represent mean copy number changes. Panel C. Karyotype showing X deletion. Positions of CNVs are indicated by the dashed boxes.
The Relationship Between Physical Activity and Cognition in Older Latinos
Creators: name: Wilbur, JoEllen
name: Marquez, David
name: Fogg, Louis
name: Wilson, Robert S
name: Staffileno, Beth A
name: Hoyem, Ruby L
name: Morris, Martha Clare
name: Bustamante, Eduardo
name: Manning, Alexis F
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: subject: Sociology
subject: FOS: Sociology

description: OBJECTIVES: The purpose of this study was to explore the relationship between minutes spent participating in light and moderate/vigorous-intensity physical activity (PA) and cognition in older Latinos, controlling for demographics, chronic health problems, and acculturation. METHOD: A cross-sectional study design was used. Participants were self-identified Latinos, without disability, who had a score less than 14 on a 21-point Mini-Mental State Examination. Participants were recruited from predominantly Latino communities in Chicago at health fairs, senior centers, and community centers. PA was measured with an accelerometer, worn for 7 days. Episodic memory and executive function (inference control, inattention, and word fluency) were measured with validated cognitive tests. RESULTS: Participants were 174 Latino men (n = 46) and women (n = 128) aged 50-84 years (M = 66 years). After adjusting for control variables (demographics, chronic health problems) and other cognitive measures, regression analyses revealed that minutes per day of light-intensity PA (r = -.51), moderate/vigorous PA (r = -.56), and counts per minute (r=-.62) were negatively associated with lower word fluency. DISCUSSION: Findings suggest that the cognitive benefits of both light-intensity PA and moderate/vigorous PA may be domain-specific.
Extending Business Motivation Modelling to Foster Regional Flexibility in IT Architecture Management
Creators: name: Hinkelmann, Knut
name: Suter, Markus
Publisher: name: IIMC International Information Management Corporation
Year: 2013
Subjects: subject: Business Motivation Modeling
subject: IT Management
subject: 330 - Wirtschaft
subject: 000 - Computer science, information & general works

description: Among the main challenges for standardisation of an IT architecture in a multinational company are the different environments in the countries, in particular regarding regulations and market specifics. Therefore, some subsidiaries have to implement local IT solutions that contradict standardisation efforts and lead to a heterogeneous IT architecture. Dynamic business environments require the on-going adaption and re-alignment of business and IT. This is particularly challenging in global multinational organisations that have to balance between standardisation and local solutions. This paper presents an extension of the OMG Business Motivation Model that supports strategic Business-IT alignment by making explicit the dependencies between a company’s strategy and the different IT architectural realisations. The approach has been developed as a case study with a multinational company and evaluated with a transformation project in a regional organisation.
Additional file 2: of Alterations of brain local functional connectivity in amnestic mild cognitive impairment
Creators: name: Zhen, Dan
name: Xia, Wei
name: Yi, Zhong
name: Zhao, Pan
name: Zhong, Jian
name: Shi, Hai
name: Li, Hua
name: Dai, Zhen
name: Pan, Ping
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Developmental Biology
subject: Mental Health

description: Subgroup meta-analysis of studies using 3.0Â T MRI scanners (Nâ =â 9). Abbreviations: N, number of datasets; ReHo, Regional Homogeneity; MNI, Montreal Neurological Institute; SDM, Seed-based d Mapping; BA, Brodmann area. (DOCX 25 kb)
Additional file 3 of Alterations of brain local functional connectivity in amnestic mild cognitive impairment
Creators: name: Zhen, Dan
name: Xia, Wei
name: Yi, Zhong
name: Zhao, Pan
name: Zhong, Jian
name: Shi, Hai
name: Li, Hua
name: Dai, Zhen
name: Pan, Ping
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Developmental Biology
subject: Mental Health
subject: Computational Biology

description: Subgroup meta-analysis of studies that matched for sex (Nâ =â 10). Abbreviations: N, number of datasets; ReHo, Regional Homogeneity; MNI, Montreal Neurological Institute; SDM, Seed-based d Mapping; BA, Brodmann area. (DOCX 24 kb)
Improving the quality of care for patients with ileocolonic Crohn’s disease undergoing surgery
Creators: name: Morar, Pritesh
Publisher: name: Imperial College London
Year: 2019

description: This thesis provides a comprehensive overview of the variability seen at time of surgery for patients with ileocolonic Crohn’s disease. It questions the validity of the Montreal classification in the setting of surgery. It provides a consensus for how a surgical service provision and the multidisciplinary team can be standardised to enhance the quality of care for patients with ileocolonic Crohn’s disease. Through meta-analysis, this thesis demonstrates that surgery is an inevitable end-point in 75% of patients who undergo endoscopic balloon dilatation for Crohn’s strictures within a 5-year follow-up period. It raises the profile of surgery as an intervention for ileocolonic Crohn’s disease, as opposed to a ‘failure of medical therapy’ and goes on to devise key performance indicators to monitor and enhance the quality of surgery for patients with ileocolonic Crohn’s disease. This thesis demonstrates that Montreal B3 (penetrating disease) and peri-operative biological therapy were both independent predictors of intra-abdominal septic complication. Further clarification is required to determine if fistulating or perforating disease specifically contributes to this effect. The newly devised, end-user informed staging tool provides distinct stages to aid this effect. Validity and reliability testing of this staging tool against a cohort of surgical patients has demonstrated it can reliably be used to pre-operatively stage patients and inform surgical decision-making and estimate post-operative morbidity. The thesis has also found that re-resectional surgery and Montreal L3 disease (ileocolonic disease) are independent predictors of recurrent disease following surgery. Montreal L3 disease is a novel finding previously un-reported and should be considered in risk stratification models for post-operative prophylactic therapy.
Improving patient safety in Libya: the way forward
Creators: name: Elmontsri, Mustafa A.
Publisher: name: Imperial College London
Year: 2019

description: Background: Patient safety has become a major public health issue. The increasing number of adverse events in healthcare has led many countries around the world to establish new organisations, regulations and policies to tackle the issue of patient safety and provide high quality care, including in Libya. There is very limited research about the issue of patient safety in developing countries and in particular Libya. The level of patient harm in developing countries is very high. There is also a lack of systematic approach towards improving patient safety. Aim: This study aimed to develop a patient safety improvement framework for healthcare settings in Libya using a pragmatic approach based on lessons from UK and subject matter expertise. Methodology: The data used to develop the conceptual framework was collected using a triangulation design method which involved literature review, documentary analysis, focus groups and a Delphi study. The framework was validated through a mixed-methods approach using questionnaires and surveys. Results: The results showed that patient safety requires a systems approach that would start with regulations and policies, education and training, information technology, leadership and management as well as patient involvement and continuous monitoring. In Libya, the priorities were mainly linked to introducing a regulatory framework to enhance the quality of care. The results are also supported by Libyan healthcare professionals, who affirmed the need for medical education reform to raise awareness about patient safety among healthcare professionals. Conclusions: The results from this study indicate that patient safety can be improved through the application of conceptual frameworks that are Libyan-oriented. This study developed a framework which will result in delivering a high quality of care to patient if established.
Additional file 1 of Integrated CNV-seq, karyotyping and SNP-array analyses for effective prenatal diagnosis of chromosomal mosaicism
Creators: name: Ma, Na
name: Xi, Hui
name: Chen, Jing
name: Peng, Ying
name: Jia, Zhengjun
name: Yang, Shuting
name: Hu, Jiancheng
name: Pang, Jialun
name: Zhang, Yanan
name: Hu, Rong
name: Wang, Hua
name: Liu, Jing
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Additional file 1. Table S1: Chromosome and CMA results on excluded mosaic cases of large cryptic genomic rearrangements..
CCWI2017: F30 'Urban Water Infrastructure Asset Management Plan: A Practical Application'
Creators: name: Ferreira, Bruno
name: Carriço, Nelson J. G.
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: This paper aims the application of the Portuguese infrastructure asset management (IAM) methodology to a case study. This methodology establishes that the IAM plan should have three distinct planning levels: strategic, tactical and operational. Each one of these levels follows a five- step structured sequence: (i) definition of objectives, assessment criteria, metrics and targets; (ii) diagnosis; (iii) plan elaboration, along with the identification, comparison and selection of alternative solutions; (iv) plan implementation; (v) plan monitoring and review. The paper will focus, mainly in steps (i) to (iii) and to the tactical level of planning. Results obtained are discussed and the main conclusions are presented.
Additional file 2 of Integrated CNV-seq, karyotyping and SNP-array analyses for effective prenatal diagnosis of chromosomal mosaicism
Creators: name: Ma, Na
name: Xi, Hui
name: Chen, Jing
name: Peng, Ying
name: Jia, Zhengjun
name: Yang, Shuting
name: Hu, Jiancheng
name: Pang, Jialun
name: Zhang, Yanan
name: Hu, Rong
name: Wang, Hua
name: Liu, Jing
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Additional file 2. Figure S1: Case 18. Panel A. CMA analysis of uncultured AF samples shows mosaic trisomy 8 (~24%). Panel B. CNV‐seq profile of the same sample shows a slightly lower ratio of mosaic trisomy 8 (~18%). The blue line represents the mean copy number and the black box represents the centromere.