The effect of benzodiazepines on exercise
Creators: name: Holgado, Darias
name: Zandonai, Thomas
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Kinesiology
subject: Exercise Science
subject: Pharmaceutics and Drug Design
subject: Pharmacy and Pharmaceutical Sciences
subject: Medicine and Health Sciences
subject: Life Sciences
subject: Medical Specialties
subject: Exercise performance
subject: Sleep quality

description: We make this registration based on the International prospective register of systematic reviews. 1. * Review title. The effect of benzodiazepines on exercise: a systematic review 2. Original language title. English 3. * Anticipated or actual start date. Literature search will start on June 2020 4. * Anticipated completion date. December 2020 5. * Stage of review at time of this submission. Some literature search related to other project has been already performed 6. * Named contact. Darías Holgado Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Dr. Holgado 7. * Named contact email. dariashn@gmail.com 8. Named contact address Corresponding Authors: Thomas Zandonai tzandonai@umh.es 9. Named contact phone number. Give the telephone number for the named contact, including international dialling code. +34 717711436 10. * Organisational affiliation of the review. Miguel Hernández University of Elche, Spain. University of Granada, Spain. Unit of Addiction Medicine, Integrated University Hospital of Verona, Italy. Institute of Health and Biomedical Research of Alicante (ISABIAL Foundation).General Hospital, Alicante, Spain Organisation web address: https://www.umh.es/ 11. * Review team members and their organisational affiliations. Dr. Darías Holgado. Mr.Agustín Manresa. Department of Sport Sciences, Sports Research Centre, Miguel Hernández University of Elche, Elche, Spain. Mr. Lorenzo Zamboni. Department of Internal Medicine, Unit of Addiction Medicine, Integrated University Hospital of Verona, Policlinico “G.B. Rossi”, Verona, Italy Dra. Ana Peiró. Neuropharmacology on Pain and Functional Diversity (NED), Institute of Health and Biomedical Research of Alicante (ISABIAL Foundation), Alicante, Spain. Pain Unit, Department of Health of Alicante-General Hospital, Alicante, Spain. Clinical Pharmacology Unit, Department of Health of Alicante - General Hospital, Alicante, Spain Dr. Thomas Zandonai. Department of Clinical Pharmacology, Paediatrics and Organic Chemistry, Miguel Hernández University of Elche, Elche, Spain. Department of Sport Sciences, Sports Research Centre, Miguel Hernández University of Elche, Elche, Spain. 12. * Funding sources/sponsors. None 13. * Conflicts of interest. None 14. Collaborators. None 15. * Review question. Population: healthy participants from all ages Intervention: Acute dose of benzodiazepine before an acute exercise or exercise programme. Comparison: Placebo or control group Outcome: Effects of benzodiazepine on exercise or pain (e.g., DOMS) Study designs: Randomized controlled trials and Non-Randomized controlled trials 16. * Searches. Database: Medline, Scopus and Web of science Keywords: ("exercise" OR "sport" OR "physical activity") AND a serie of benzodiazepine drugs: (“benzodiazepine” OR “alprazolam” OR “bromazepam” OR “brotizolam” OR “clobazam” OR “clonazepam” OR “clorazepate” OR “chlordiazepoxide” OR “clotiazepam” OR “delorazepam”OR “diazepam” OR “estazolam” OR “etizolam” OR “flunitrazepam”OR “flurazepam” OR “ketazolam” OR “lorazepam” OR “lormetazepam” OR “midazolam” OR “nitrazepam” OR “nordazepam” OR “oxazepam” OR “pinazepam” OR “prazepam” OR “temazepam” OR “triazolam”)) Date: from any time to 2020 Language: English 17. URL to search strategy. Do not make this file publicly available until the review is complete 18. * Condition or domain being studied. We will study the effect of benzodiazepines on exercise performance and sleep quality. We will perform a systematic review. 19. * Participants/population. Participants will be healthy male or female. No age limit will be set for this research. Participants in poor health condition will be excluded. 20. * Intervention(s), exposure(s). The effect of acute or regular dose of any benzodiazepine drugs on exercise performance. 21. * Comparator(s)/control. In studies with comparison group it will be an placebo or control group. 22. * Types of study to be included. 1. Randomised control trials (RCTs) and non-randomised Control trials (non-RCTs) including experimental studies and observational studies (cross-sectional, case-control and cohort studies) 2. Published as original research in a peer-reviewed journal or open access repository. 3. Published as full-text. 4. Human healthy participants. 5. Participants ≥18 years of age. 6. No restrictions towards gender, ethnicity and follow-up duration (in case of longitudinal studies). 24. * Main outcome(s). The main outcomes are measures of exercise performance. Exercise performance outcome: time trial performance, time-to-exhaustion performance, number of repetitions in given exercise, total work done, perception of effort. 25. * Additional outcome(s). List the pre-specified additional outcomes of the review, with a similar level of detail to that required for main outcomes. Where there are no additional outcomes please state ‘None’ or ‘Not applicable’ as appropriate to the review Additionally, if available, we might assess pain perception via visual analog scale, pressure test, etc. and sleep quality. 26. * Data extraction (selection and coding). From each study, we will extract the following information: Authors and year of publication; type, dose and number of intake of benzodiazepine; age population; number participants; type of exercise performed; exercise intensity; exercise duration; main outcome, secondary outcome. Darías Holgado and Agustín Manresa will extract the information from the studies. If any data is missing in the original manuscript, we will contact with the corresponding author to obtain the data. 27. * Risk of bias (quality) assessment. We will use the RoB to assess the risk of bias of the included studies 28. * Strategy for data synthesis. Systematic review 29. * Analysis of subgroups or subsets. Non applicable 30. * Type and method of review. Systematic review. 31. Language. English 32. Country. Spain 34. Reference and/or URL for published protocol. Data will be available in the following link: https://osf.io/vcfnh/ Do you intend to publish the review on completion? Yes 35. Dissemination plans. We will submit the review to peer review journals and in open-access repositories. 36. Keywords. Sleep quality; athletes; Recovery; Sport; Pain. 37. Details of any existing review of the same topic by the same authors. We are not aware of previous review on this topic. 38. * Current review status. Not started 39. Any additional information. None