cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Molecular Gas in the X-ray Bright Group NGC 5044 as Revealed by ALMA
Creators: name: David, Laurence P.
name: Lim, Jeremy
name: Forman, William
name: Vrtilek, Jan
name: Combes, Francoise
name: Salome, Philippe
name: Edge, Alastair
name: Jones, Christine
name: Sun, Ming
name: O'Sullivan, Ewan
name: Gastaldello, Fabio
name: Temi, Pasquale
name: Schmitt, Henrique
name: Ohyama, Youichi
name: Hamer, Stephen
name: Mathews, William
name: Brighenti, Fabrizio
name: Giacintucci, Simona
name: Bardelli, Sandro
name: Trung, Dinh-V
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: A short 30 minute ALMA observation of the early-type galaxy NGC 5044, which resides at the center of an X-ray bright group with a moderate cooling flow, has detected 24 molecular structures within the central 2.5 kpc. The masses of the molecular structures vary from 3e5 to 1e7 Mo3 and the CO(2-1) linewidths vary from 15 to 65 km/s. Given the large CO(2-1) linewidths, the observed structures are likely giant molecular associations (GMAs) and not individual molecular clouds (GMCs). Only a few of the GMAs are spatially resolved with the cycle 0 ALMA beam and the average density of these GMAs yields a GMC volume filling factor of about 15%. The observed masses of the resolved GMAs are insufficient for them to be gravitationally bound, however, the most massive GMA does contain a less massive component with a linewidth of 5.5 km/s (typical of an individual virialized GMC). We also show that the GMAs cannot be pressure confined by the hot gas. Given the observed CO(2-1) linewidths of the GMAs (i.e., the velocity dispersion of the embedded GMCs) they will likely disperse on a timescale of about 12 Myr, which is less than the central cooling time of the hot gas, so the embedded GMCs within a GMA must condense out of the hot gas at the same time and arise from local concentrations of thermally unstable parcels of hot gas. There are no indications of any disk-like molecular structures and all indications suggest that the molecular gas follows ballistic trajectories after condensing out of the thermally unstable hot gas. The 230 GHz luminosity of the central continuum source is 500 times greater than its low frequency radio luminosity and probably reflects a recent accretion event by the central supermassive black hole. The spectrum of the central continuum source also exhibits an absorption feature.
Transport industry workforce risk and exposure to COVID-19 and other related respiratory pandemic diseases: A scoping review
Creators: name: Jegasothy, Edward
name: Chughtai, Abrar
name: Seale, Holly
name: Qureshi, Mohammed Owais
name: Harris, Patrick
name: Quinlan, Michael
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Medicine and Health Sciences
subject: Social and Behavioral Sciences

description: The transport industry workforce is not homogenous and involves workers who are potentially vulnerable both to contracting the virus and to pandemic management strategies. Some transport workers may be more from minorities or socioeconomically disadvantaged groups, and work conditions may be precarious, with unclear responsibilities over worker safety and welfare. As such, transport workers may be more susceptible to the risk of respiratory diseases than the general population. Transport workers may also be vulnerable to loss of income during periods of restrictions and economic decline. The aim of this scoping review was to understand the current state of research on the impact of respiratory pandemic diseases on transport workers and to identify existing evidence-based recommendations to facilitate mitigate the risks associated with these diseases in the transport industry.
Adjusting power for a baseline covariate in linear models
Creators: name: Muller, Keith E.
name: Glueck, Deborah H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: The analysis of covariance provides a common approach to adjusting for a baseline covariate in medical research. With Gaussian errors, adding random covariates does not change either the theory or the computations of general linear model data analysis. However, adding random covariates does change the theory and computation of power analysis. Many data analysts fail to fully account for this complication in planning a study. We present our results in five parts. (i) A review of published results helps document the importance of the problem and the limitations of available methods. (ii) A taxonomy for general linear multivariate models and hypotheses allows identifying a particular problem. (iii) We describe how random covariates introduce the need to consider quantiles and conditional values of power. (iv) We provide new exact and approximate methods for power analysis of a range of multivariate models with a Gaussian baseline covariate, for both small and large samples. The new results apply to the Hotelling-Lawley test and the four tests in the “univariate” approach to repeated measures (unadjusted, Huynh-Feldt, Geisser-Greenhouse, Box). The techniques allow rapid calculation and an interactive, graphical approach to sample size choice. (v) Calculating power for a clinical trial of a treatment for increasing bone density illustrates the new methods. We particularly recommend using quantile power with a new Satterthwaite-style approximation.
Appunti per una semiotica storica del bianco in architettura
Creators: name: Perini Folesani, Giovanna
Publisher: name: Opus Incertum
Year: 2017

description: The paper is a short survey of the meaning and value of the colour white in western architecture from the Middle Ages to the end of the 18th century, based on a selective commentary of often well-known passages from major art literature sources. A special emphasis is obviously placed on theoretical texts such as Alberti’s De re aedificatoria and Serlio’s treatise, but also on 16th century Italian books on the emblematic meaning of colours (e.g., Morato, Sicillo Araldo).
description: Opus Incertum, Vol 2 (2016)
Adaptive dose finding based ont-statistic for dose–response trials
Creators: name: Perevozskaya, Inna
name: Bolognese, James A.
name: Ivanova, Anastasia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The goals of phase II dose–response studies are to prove that the treatment is effective and to choose the dose for further development. Randomized designs with equal allocation to either a high dose and placebo or to each of several doses and placebo are typically used. However, in trials where response is observed relatively quickly, adaptive designs might offer an advantage over equal allocation. We propose an adaptive design for dose–response trials that concentrates the allocation of subjects in one or more areas of interest, for example, near a minimum clinically important effect level, or near some maximal effect level, and also allows for the possibility to stop the trial early if needed. The proposed adaptive design yields higher power to detect a dose–response relationship, higher power in comparison with placebo, and selects the correct dose more frequently compared with a corresponding randomized design with equal allocation to doses.
Asymptotic symmetries and subleading soft graviton theorem
Creators: name: Campiglia, Miguel
name: Laddha, Alok
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Motivated by the equivalence between soft graviton theorem and Ward identities for the supertranslation symmetries belonging to the BMS group, we propose a new extension (different from the so-called extended BMS) of the BMS group which is a semi-direct product of supertranslations and Diff(S^2). We propose a definition for the canonical generators associated to the smooth diffeomorphisms and show that the resulting Ward identities are equivalent to the subleading soft graviton theorem of Cachazo and Strominger.
description: 25 pages, published version
Senso del colore e assenza di colori nell’architettura sacra medievale e nelle sue ‘rivisitazioni’ in Italia: qualche considerazione sulla facies esterna
Creators: name: Fachechi, Grazia Maria
Publisher: name: Opus Incertum
Year: 2017

description: As Michael Pastoureau contends, the Middle Ages was the era of colour, when many things had the “right to colour”. Things that would not be polychrome anymore in the modern and contemporary age, such as building facades and sculptures (he says so, but of course it is just a generalization), which will instead conform to a purely monochromatic, often totally white, aesthetic. Though during the Middle Ages a polychromatic appearance of buildings and sculptures was usually preferred, we have extraordinary examples of Cistercian buildings where colour was programmatically refused (even stained glass windows were in grisaille), which influenced modern and contemporary architects, such as Le Corbusier. So, we can say that the Middle Ages continued and strengthened the relationship between form and colour which characterized the temples and sculptures of Antiquity. Even though studies on polychromy in Medieval monuments have recently become more common, we still lack a critical overview that, based on single case studies, can interpret the data and answer the questions: what was the "chromatic approach" of the Medieval architect, and how did he express it?
description: Opus Incertum, Vol 2 (2016)
Phase separation in doped Mott insulators
Creators: name: Yee, Chuck-Hou
name: Balents, Leon
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Motivated by the commonplace observation of Mott insulators away from integer filling, we construct a simple thermodynamic argument for phase separation in first-order doping-driven Mott transitions. We show how to compute the critical dopings required to drive the Mott transition using electronic structure calculations for the titanate family of perovskites, finding good agreement with experiment. The theory predicts the transition is percolative and should exhibit Coulomb frustration.
description: Updated acknowledgements
High-Quality BN-Graphene-BN Nanoribbon Capacitors Modulated by Graphene Side-gate Electrodes
Creators: name: Wang, Yang
name: Chen, Xiaolong
name: Ye, Weiguang
name: Wu, Zefei
name: Han, Yu
name: Han, Tianyi
name: He, Yuheng
name: Cai, Yuan
name: Wang, Ning
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: High-quality BN-Graphene-BN nanoribbon capacitors with double side-gates of graphene are experimentally realized. Graphene electronic properties can be significantly modulated by the double side-gates. The modulation effects are very obvious and followed the metallic electrode behavior of numerical simulations, while the theoretically predicted negative quantum capacitance was not observed, possibility due to the over-estimated or weakened interactions between the graphene nanoribbon and side-gate electrodes.
AARP Houston Mayoral Survey
Creators: name: AARP
Publisher: name: Roper Center for Public Opinion Research
Year: 2025

description: Council member/City Council job approval (2); Mayor job approval (1); likely to vote in mayoral primary (1); jobs/economy (1); inflation (1); housing (6); utilities (2); senior support services (4); transportation/walkability (8); crime/personal safety (4); natural disaster response (1); internet (2); access to affordable, healthy food options (1); green space (1); personal financial situation (1); current employment status (1); confidence in being able to retire (1); thoughts of moving away (1); property taxes (2); abandoned properties (1).
An R 2 statistic for fixed effects in the linear mixed model
Creators: name: Schabenberger, Oliver
name: Wolfinger, Russell D.
name: Edwards, Lloyd J.
name: Muller, Keith E.
name: Qaqish, Bahjat F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Statisticians most often use the linear mixed model to analyze Gaussian longitudinal data. The value and familiarity of the R2 statistic in the linear univariate model naturally creates great interest in extending it to the linear mixed model. We define and describe how to compute a model R2 statistic for the linear mixed model by using only a single model. The proposed R2 statistic measures multivariate association between the repeated outcomes and the fixed effects in the linear mixed model. The R2 statistic arises as a 1–1 function of an appropriate F statistic for testing all fixed effects (except typically the intercept) in a full model. The statistic compares the full model to a null model with all fixed effects deleted (except typically the intercept) while retaining exactly the same covariance structure. Furthermore, the R2 statistic leads immediately to a natural definition of a partial R2 statistic. A mixed model in which ethnicity gives a very small p-value as a longitudinal predictor of blood pressure compellingly illustrates the value of the statistic. In sharp contrast to the extreme p-value, a very small R2, a measure of statistical and scientific importance, indicates that ethnicity has an almost negligible association with the repeated blood pressure outcomes for the study.
Mura di luce, facciate di diamanti. Metafore del bianco nell’architettura del Quattrocento
Creators: name: Bevilacqua, Mario
Publisher: name: Opus Incertum
Year: 2017

description: Building with light: a utopian idea that in its incessant changing of meaning, techniques and functions, crosses the entire history of western architecture. Raising crystal walls - transparent, or made of gold, of gems and diamonds, in other words of light - is an inherently Christian metaphor, though by no means applied to sacred architecture only. High and mighty walls of shining precious stones defend the Celestial Jerusalem: pure white, as evoked in specific working techniques of stone walls, is thus a metaphor for strength, protection, salvation, that finds abundant use in civil architecture. Out of a variety of late Mediaeval examples, during the second half of the 15th century emerges the theme of the “diamond palace”: not a building typology or a specific model, as intended so far, but rather a wall's finishing work that can be found in a great variety of contexts with military, defensive meanings. In the earliest and most ambitious examples (Naples, Milan, Finalborgo, Ferrara), the residence of the soldier, miles christianus, becomes an ideal bastion of faith, built, like the walls of the Celestial Jerusalem, from gems and light.
description: Opus Incertum, Vol 2 (2016)
Regression splines in the time-dependent coefficient rates model for recurrent event data
Creators: name: Cai, Jianwen
name: Zeng, Donglin
name: Amorim, Leila D.
name: Barreto, Maurício L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Many epidemiologic studies involve the occurrence of recurrent events and much attention has been given for the development of modelling techniques that take into account the dependence structure of multiple event data. This paper presents a time-dependent coefficient rates model that incorporates regression splines in its estimation procedure. Such method would be appropriate in situations where the effect of an exposure or covariates changes over time in recurrent event data settings. The finite sample properties of the estimators are studied via simulation. Using data from a randomized community trial that was designed to evaluate the effect of vitamin A supplementation on recurrent diarrheal episodes in small children, we model the functional form of the treatment effect on the time to the occurrence of diarrhea. The results describe how this effect varies over time. In summary, we observed a major impact of the vitamin A supplementation on diarrhea after 2 months of the dosage, with the effect diminishing after the third dosage. The proposed method can be viewed as a flexible alternative to the marginal rates model with constant effect in situations where the effect of interest may vary over time.
Bilingualism and Listening Effort for Speech in Noise
Creators: name: Van Engen, Kristin
name: Carraturo, Sita
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Linguistics
subject: FOS: Languages and literature
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: This project seeks to quantify listening effort for a range of listeners (monolinguals, simultaneous bilinguals, early bilinguals, and late bilinguals) for speech in noise stimuli
Summarizing differences in cumulative incidence functions
Creators: name: Zhang, Mei-Jie
name: Fine, Jason
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The cumulative incidence function is widely reported in competing risks studies, with group differences assessed by an extension of the log-rank test. However, simple, interpretable summaries of group differences are not available. An adaptation of the proportional hazards model to the cumulative incidence function is often employed, but the interpretation of the hazard ratio may be somewhat awkward, unlike the usual survival set-up. We propose nonparametric inferences for general summary measures, which may be time-varying, and for time-averaged versions of the measures. Theoretical justification is provided using counting process techniques. A real data example illustrates the practical utility of the methods.
A robust method for comparing two treatments in a confirmatory clinical trial via multivariate time-to-event methods that jointly incorporate information from longitudinal and time-to-event data
Creators: name: Saville, Benjamin R.
name: Koch, Gary G.
name: Herring, Amy H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: We consider regulatory clinical trials that required a pre-specified method for the comparison of two treatments for chronic diseases (e.g. Chronic Obstructive Pulmonary Disease) in which patients suffer deterioration in a longitudinal process until death occurs. We define a composite endpoint structure that encompasses both the longitudinal data for deterioration and the time-to-event data for death, and use multivariate time-to-event methods to assess treatment differences on both data structures simultaneously, without a need for parametric assumptions or modeling. Our method is straightforward to implement, and simulations show the method has robust power in situations in which incomplete data could lead to lower than expected power for either the longitudinal or survival data. We illustrate the method on data from a study of chronic lung disease.
Connecting horizon pixels and interior voxels of a black hole
Creators: name: Nicolini, Piero
name: Singleton, Douglas
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper we discuss to what extent one can infer details of the interior structure of a black hole based on its horizon. Recalling that black hole thermal properties are connected to the non-classical nature of gravity, we circumvent the restrictions of the no hair theorem by postulating that the black hole interior is singularity free due to violations of the usual energy conditions. Further these conditions allow one to establish a one-to-one, holographic projection between Planckian areal "bits" on the horizon and "voxels", representing the gravitational degrees of freedom in the black hole interior. We illustrate the repercussions of this idea by discussing an example of the black hole interior consisting of a de Sitter core postulated to arise from the local graviton quantum vacuum energy. It is shown that the black hole entropy can emerge as the statistical entropy of a gas of voxels.
description: 10 pages, 0 figures, published version with note added
An adaptive design for identifying the dose with the best efficacy/tolerability profile with application to a crossover dose-finding study
Creators: name: Ivanova, Anastasia
name: Snyder, Ellen
name: Snavely, Duane
name: Liu, Ken
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Proof-of-concept in clinical trials has traditionally focused on identification of a maximum tolerated dose with the assumption that the higher doses provide better efficacy. However adverse events associated with a maximum tolerated dose may have a negative effect on efficacy. We present an efficient adaptive dose-finding strategy which concentrates patient assignments at and around the dose which has the best efficacy/tolerability profile based on a utility function. The strategy is applied within the setting of a crossover design. While the strategy may also be applied to parallel studies, a crossover design provides more power for a given sample size for comparisons between the optimal dose versus placebo and/or active control when it is reasonable to assume no carryover effects.
Gradient Estimates of Mean Curvature Equations with Neumann Boundary Condition
Creators: name: Ma, Xi-Nan
name: Xu, Jinju
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: In this paper, we use the maximum principle to get the gradient estimate for the solutions of the prescribed mean curvature equation with Neumann boundary value problem, which gives a positive answer for the question raised by Lieberman \cite{Lieb13} in page 360. As a consequence, we obtain the corresponding existence theorem for a class of mean curvature equations. Moreover we can get a new proof of the gradient estimates for the mean curvature equation with prescribed contact angle boundary value problem.
description: This is our second version. Welcome all comments
Real longitudinal data analysis for real people: Building a good enough mixed model
Creators: name: Cheng, Jing
name: Edwards, Lloyd J.
name: Muller, Keith E.
name: Maldonado-Molina, Mildred M.
name: Komro, Kelli A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Mixed effect models have become very popular, especially for the analysis of longitudinal data. One challenge is how to build a good enough mixed effects model. In this paper, we suggest a systematic strategy for addressing this challenge and introduce easily implemented practical advice to build mixed effect models. A general discussion of scientific strategies motivates the recommended five step procedure for model fitting. The need to model both the mean structure (the fixed effects) and the covariance structure (the random effects and residual error) creates the fundamental flexibility and complexity. Some very practical recommendations help conquer the complexity. Centering, scaling, and full-rank coding all predictor variables radically improves the chances of convergence, computing speed, and numerical accuracy. Applying computational and assumption diagnostics from univariate linear models to mixed model data greatly helps detect and solve related computational problems. Applying computational and assumption diagnostics from univariate linear models to mixed model data can radically improve the chances of convergence, computing speed, and numerical accuracy. The approach helps fit more general covariance models, a crucial step in selecting a credible covariance model needed for defensible inference. A detailed demonstration of the recommended strategy is based on data from a published study of a randomized trial of a multicomponent intervention to prevent young adolescents' alcohol use. The discussion highlights a need for additional covariance and inference tools for mixed models. The discussion also highlights the need for improving how scientists and statisticians teach and review the process of finding a good enough mixed model.
The Lost Generation of Autistic Women’s Experiences of Secondary School: An Interpretative Phenomenological Analysis Approach
Creators: name: Dark, J.
Publisher: name: School of Psychology, University of East London
Year: 2022

description: This paper focuses on the “lost generation” of autistic women’s experiences of secondary school using an interpretative phenomenological analysis (IPA) approach. Autistic women were supported through inclusive research practices to share their experiences of secondary school as an unrecognised autistic child, as captured through an online questionnaire and semi-structured interview. The core features of the cohort included a diagnosis of autism post eighteen years old, and attendance at a mainstream secondary school in the United Kingdom. The findings highlight the participants’ difficult experiences, including bullying, difficult relationships with peers, sensory difficulties within their school environment and processing differences within their learning. The findings also showed two areas that positively contributed to their school experiences, including friendships and positive relationships with teachers. Discussions centre on the benefits that autistic adults bring to informing educational enquiry and why the phenomenon of the lost generation of autistic girls is still a current concern.
Bianco e colori. Sigismondo Malatesta, Alberti, e l’architettura del Tempio Malatestiano
Creators: name: Bulgarelli, Massimo
Publisher: name: Opus Incertum
Year: 2017

description: The use of white Istrian stone on the exterior of the Tempio Malatestiano in Rimini is due to a variety of reasons. On the one hand it is a reference to the evocative power of the colour white in ancient Roman architecture, recalling the origins of the city - the arch of Augustus and the bridge of Augustus and Tiberius - as well as, in more general terms, an Imperial attribute, already recorded in ancient literary sources, and well known by Leon Battista Alberti and the humanists at the court of Sigismondo Malatesta. On the other hand, the colour white is one of the aspects of the identification of the patron and the building. Together with white, in fact, red and green are also used – in the marble crustae of the gateway and in the painted traces of wall surfaces found recently on the sides of the building - showing the heraldic colours of the Malatesta. The Temple, like Castel Sismondo, was adopted as an emblematic image in Sigismondo's medals together with the family livery.
description: Opus Incertum, Vol 2 (2016)
Evidence on public involvement and engagement in adult health and care research in the United Kingdom - a scoping review protocol.
Creators: name: Webster, Jay
name: Davis, Bridget
name: Todhunter-Brown, Alex
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Medicine and Health Sciences
subject: Citizen participation
subject: Health research
subject: Knowledge
subject: Lay-persons
subject: PPI
subject: PPIE
subject: Public engagement
subject: Public involvement

description: PhD Scoping review protocol
«Il bellissimo bianco» della Sacrestia Nuova: Michelangelo, Vasari, Borghini e la tradizione fiorentina come nuova identità medicea
Creators: name: Carrara, Eliana
name: Ferretti, Emanuela
Publisher: name: Opus Incertum
Year: 2017

description: The story of the San Lorenzo complex is closely linked to the Medici family, as a rich historiography has well documented. Much research has been devoted to the patronage of Giovanni di Bicci and Cosimo il Vecchio. Intensive research has also been carried out on Michelangelo's Sacrestia Nuova, and the role played in it by Popes Leo X and Clement VII. Only recently was the connection between the two branches of the family and the church of San Lorenzo explored: the Medici descendants of Cosimo the Elder and those of Pier Francesco il Popolano, which would then generate the dynasty of the Grand Dukes of Tuscany. The paper analyses the role of Cosimo I in the commission of the Sacrestia Nuova, that was to remain unfinished due to Michelangelo's departure from Florence in 1534. The Sacrestia became a sort of laboratory where the various trends of the Ducal policy of the arts could meet: the connection with the main line of the family; the reflection on Quattrocento artistic tradition; the dialogue with Michelangelo's heritage. A new picture emerges, in which Giorgio Vasari and Vincenzio Borghini's intervention appears as fundamental in the definition of the facies of the chapel, later to be put in question by the restoration works commissioned by the Palatine Electress in the third decade of the 18th century, to such an extent that it can be said that two centuries of 'Medici expressiveness' are reflected in the Sacrestia Nuova.
description: Opus Incertum, Vol 2 (2016)
Investigating the Associations Between Cisgender Women’s Orgasm Experiences, Perceived Partner Responsiveness and Sexual Wellbeing Among Community Women and their Partners
Creators: name: Rosen, Natalie
name: Belu, Charlene Florica
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Social and Behavioral Sciences

description: This dyadic research will examine the associations between the orgasm experiences of cisgender women and sexual wellbeing (i.e., sexual desire, sexual distress, sexual satisfaction) for both members of a couple. This study will use both longitudinal and daily diary methods to examine these associations. This research will also examine whether perceived partner responsiveness moderates the association between orgasm experience and sexual wellbeing. Gender/sex diverse couples from Canada and the United States were recruited from previous lab contacts, social media, or via physical posters placed in cities across Canada. Couples were recruited to complete a baseline survey, brief daily surveys for 28 days, and a follow up survey 4 months later.
Palladio a colori, Palladio in bianco e nero: il mito del bianco nell’architettura palladiana
Creators: name: Paternò, Damiana Lucia
Publisher: name: Opus Incertum
Year: 2017

description: In Palladio's architecture the choice of colour is strictly related to the use of specific materials: stone, plaster, rectified bricks. His buildings can vary from the candid white of Istrian stone, to the warmer tones of Vicenza stone, and the bright red that characterises some of his buildings at the beginning of his Venetian period. The Four Books of Architecture, although at the origin of Palladio's fame, have created the dogma of an exclusively monochrome Palladio, white and stony. From the early 17th century, the parts in red stucco were often hidden under layers of 'fake stone' plaster with the purpose of correcting what was considered to be an error ascribable to unqualified craftsmanship and problems related to the construction site. An interpretation which was considered accurate until very recently, then refuted in the last decades of the 20th century thanks to a more careful attention to the materiality of Palladio's built structures.
description: Opus Incertum, Vol 2 (2016)
Pseudogap, charge order, and pairing density wave at the hot spots in cuprate superconductors
Creators: name: Pépin, C.
name: de Carvalho, V. S.
name: Kloss, T.
name: Montiel, X.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We address the timely issue of the presence of charge ordering at the hot-spots in the pseudo-gap phase of cuprate superconductors in the context of an emergent SU(2)-symmetry which relates the charge and pairing sectors. Performing the Hubbard-Stratonovich decoupling such that the free energy stays always real and physically meaningful we exhibit three solutions of the spin-fermion model at the hot spots. A careful examination of their stability and free energy shows that, at low temperature, the system tends towards a co-existence of charge density wave (CDW) and the composite order parameter made of diagonal quadrupolar density wave and pairing fluctuations of Ref. [Nat. Phys. $\bf{9}$, 1745 (2013)].The CDW is sensitive to the shape of the Fermi surface in contrast to the diagonal quadrupolar order, which is immune to it. SU(2) symmetry within the pseudo-gap phase also applies to the CDW state, which therefore admits a pairing density pave counterpart breaking time reversal symmetry.
description: 15 pages, 15 figures, final version + typo corrected in Eq. (12)
Reinforcement learning design for cancer clinical trials
Creators: name: Zeng, Donglin
name: Kosorok, Michael R.
name: Zhao, Yufan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: We develop reinforcement learning trials for discovering individualized treatment regimens for life-threatening diseases such as cancer. A temporal-difference learning method called Q-learning is utilized which involves learning an optimal policy from a single training set of finite longitudinal patient trajectories. Approximating the Q-function with time-indexed parameters can be achieved by using support vector regression or extremely randomized trees. Within this framework, we demonstrate that the procedure can extract optimal strategies directly from clinical data without relying on the identification of any accurate mathematical models, unlike approaches based on adaptive design. We show that reinforcement learning has tremendous potential in clinical research because it can select actions that improve outcomes by taking into account delayed effects even when the relationship between actions and outcomes is not fully known. To support our claims, the methodology's practical utility is illustrated in a simulation analysis. In the immediate future, we will apply this general strategy to studying and identifying new treatments for advanced metastatic stage IIIB/IV non-small cell lung cancer, which usually includes multiple lines of chemotherapy treatment. Moreover, there is significant potential of the proposed methodology for developing personalized treatment strategies in other cancers, in cystic fibrosis, and in other life-threatening diseases.
A Bayesian proportional hazards regression model with non-ignorably missing time-varying covariates
Creators: name: Bradshaw, Patrick T.
name: Gammon, Marilie D.
name: Ibrahim, Joseph G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Missing covariate data is common in observational studies of time to an event, especially when covariates are repeatedly measured over time. Failure to account for the missing data can lead to bias or loss of efficiency, especially when the data are non-ignorably missing. Previous work has focused on the case of fixed covariates rather than those that are repeatedly measured over the follow-up period, so here we present a selection model that allows for proportional hazards regression with time-varying covariates when some covariates may be non-ignorably missing. We develop a fully Bayesian model and obtain posterior estimates of the parameters via the Gibbs sampler in WinBUGS. We illustrate our model with an analysis of post-diagnosis weight change and survival after breast cancer diagnosis in the Long Island Breast Cancer Study Project (LIBCSP) follow-up study. Our results indicate that post-diagnosis weight gain is associated with lower all-cause and breast cancer specific survival among women diagnosed with new primary breast cancer. Our sensitivity analysis showed only slight differences between models with different assumptions on the missing data mechanism yet the complete case analysis yielded markedly different results.
Uncovering Randomness and Success in Society
Creators: name: Jalan, Sarika
name: Sarkar, Camellia
name: Madhusudanan, Anagha
name: Dwivedi, Sanjiv Kumar
Publisher: name: arXiv
Year: 2014
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: An understanding of how individuals shape and impact the evolution of society is vastly limited due to the unavailability of large-scale reliable datasets that can simultaneously capture information regarding individual movements and social interactions. We believe that the popular Indian film industry, 'Bollywood', can provide a social network apt for such a study. Bollywood provides massive amounts of real, unbiased data that spans more than 100 years, and hence this network has been used as a model for the present paper. The nodes which maintain a moderate degree or widely cooperate with the other nodes of the network tend to be more fit (measured as the success of the node in the industry) in comparison to the other nodes. The analysis carried forth in the current work, using a conjoined framework of complex network theory and random matrix theory, aims to quantify the elements that determine the fitness of an individual node and the factors that contribute to the robustness of a network. The authors of this paper believe that the method of study used in the current paper can be extended to study various other industries and organizations.
description: 39 pages, 12 figures, 14 tables
A linear exponent AR(1) family of correlation structures
Creators: name: Sen, Pranab K.
name: Simpson, Sean L.
name: Styner, Martin A.
name: Muller, Keith E.
name: Edwards, Lloyd J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: In repeated measures settings, modeling the correlation pattern of the data can be immensely important for proper analyses. Accurate inference requires proper choice of the correlation model. Optimal efficiency of the estimation procedure demands a parsimonious parameterization of the correlation structure, with sufficient sensitivity to detect the range of correlation patterns that may occur. Many repeated measures settings have within-subject correlation decreasing exponentially in time or space. Among the variety of correlation patterns available for this context, the continuous-time first-order autoregressive correlation structure, denoted AR(1), sees the most utilization. Despite its wide use, the AR(1) structure often poorly gauges within-subject correlations that decay at a slower or faster rate than required by the AR(1) model. To address this deficiency we propose a two-parameter generalization of the continuous-time AR(1) model, termed the linear exponent autoregressive (LEAR) correlation structure, which accommodates much slower and much faster decay patterns. Special cases of the LEAR family include the AR(1), compound symmetry, and first-order moving average correlation structures. Excellent analytic, numerical, and statistical properties help make the LEAR structure a valuable addition to the suite of parsimonious correlation models for repeated measures data. Both medical imaging data concerning neonate neurological development and longitudinal data concerning diet and hypertension [DASH (Dietary Approaches to Stop Hypertension) study] exemplify the utility of the LEAR correlation structure.
A weighted combination of pseudo-likelihood estimators for longitudinal binary data subject to non-ignorable non-monotone missingness
Creators: name: Ibrahim, Joseph G.
name: Molenberghs, Geert
name: Lipsitz, Stuart R.
name: Fitzmaurice, Garrett M.
name: Troxel, Andrea B.
name: Sinha, Debajyoti
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: For longitudinal binary data with non-monotone non-ignorably missing outcomes over time, a full likelihood approach is complicated algebraically, and with many follow-up times, maximum likelihood estimation can be computationally prohibitive. As alternatives, two pseudo-likelihood approaches have been proposed that use minimal parametric assumptions. One formulation requires specification of the marginal distributions of the outcome and missing data mechanism at each time point, but uses an “independence working assumption,” i.e., an assumption that observations are independent over time. Another method avoids having to estimate the missing data mechanism by formulating a “protective estimator.” In simulations, these two estimators can be very inefficient, both for estimating time trends in the first case and for estimating both time-varying and time-stationary effects in the second. In this paper, we propose use of the optimal weighted combination of these two estimators, and in simulations we show that the optimal weighted combination can be much more efficient than either estimator alone. Finally, the proposed method is used to analyze data from two longitudinal clinical trials of HIV-infected patients.
Bianco come mimesi, allusione, fusione. Bernini, Borromini… Mies van der Rohe
Creators: name: Sturm, Saverio
Publisher: name: Opus Incertum
Year: 2017

description: There is a series of various meanings and intentions which led the foremost masters of Baroque architecture to choose the colour white as the characterising element for certain environments. Bernini choses the monochrome palette for interior spaces destined to the nobility, but more often searches, through the grain and chromatic purity of Roman travertine, the ideal of a “naturalised” architecture, as mimesis of the natural world. Grafted instead with erudite allegorical references, Borromini's candid architecture does not want to represent an imitative or narrative nature, but rather a convincing allusion to the acting forces, to the dramatic tensions and symbolic meanings that pervade it. A possible synthesis between the two positions is identifiable in the work of Ludwig Mies van der Rohe, notwithstanding the evident contextual difference. His obsessive attention to detail and technical solutions recalls Borromini's methods, whereas his use of colours is closer to Bernini. Only in the case of Farnsworth House did Mies choose a purely white architecture: a deliberate neutralisation of the building elements, with the purpose of ceding the main role to the surrounding nature, thus allowing a visual and ideal fusion with the polychromatic nature of the Illinois forest.
description: Opus Incertum, Vol 2 (2016)
Imprensa da Universidade do Recife (1955-1972) : uma história contada através de seus livros, práticas e agentes
Creators: name: , FERNANDES
Publisher: name: Zenodo
Year: 2019
Subjects: editora universitária
tipografia
university press
memória
artista gráfica

description: The present dissertation aims to investigate the University Press of the University of Recife, its print shop and its publications. Through a historic approach, the university print is discussed since its beginning, in 1955, until the end when became publishing company, in 1972. Of these almost two decades, are raised and discussed its creation context and structuration as institutional body of the university. The graphic workshop, the most widely discussed sector, is conceptualized and has exposed its composition and printing practices, as well as its agents, consisting of an investigative work through the various sources consulted, thus reaching publications from this office. More than seventy books were cataloged and observed, generating a sufficient amount of data that helped to trace the trajectory of theuniversity press in the period. Treating these books as objects of information, they star in the final part of the dissertation, demonstrating through a diverse and heterogeneous production, the productive phases through which the organ went through. With this deepening in the books, more accurately and carefully on the covers, a direct relationship with graphic artists of the period is established that, over the years, become part of the Press (internal and external) as agents. Thus, it was possible to perceive the degree of importance of this sector, within the editorial and graphic scenario of Pernambuco, especially in the 1960s.
Scanning localized magnetic fields in a microfluidic device with a single nitrogen vacancy center
Creators: name: Lim, Kangmook
name: Ropp, Chad
name: Shapiro, Benjamin
name: Taylor, Jacob M.
name: Waks, Edo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Nitrogen vacancy (NV) color centers in diamond have emerged as highly versatile optical emitters that exhibit room temperature spin properties. These characteristics make NV centers ideal for magnetometry, which plays an important role in chemical and biological sensing applications. The integration of NV magnetometers with microfluidic systems could enable the study of isolated chemical and biological samples in a fluid environment with high spatial resolution. Here we demonstrate a method to perform localized magnetometry with nanometer spatial precision using a single NV center in a microfluidic device. We manipulate a magnetic particle within a liquid environment using a combination of planar microfluidic flow control and vertical magnetic actuation to achieve 3-dimensional manipulation. A diamond nanocrystal containing a single NV center is deposited in the microfluidic channels and acts as a local magnetic field probe. We map out the magnetic field distribution of the magnetic particle by varying its position relative to the diamond nanocrystal and performing optically resolved electron spin resonance (ESR) measurements. We control the magnetic particle position with a 48 nm precision and attain a magnetic field sensitivity of 17.5 microTesla/Hz^1/2. These results open up the possibility for studying local magnetic properties of biological and chemical systems with high sensitivity in an integrated microfluidic platform.
description: 14 pages, 4 figures
On the estimation of disease prevalence by latent class models for screening studies using two screening tests with categorical disease status verified in test positives only
Creators: name: Cole, Stephen R.
name: Ibrahim, Joseph G.
name: Zhou, Yijie
name: Chu, Haitao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: To evaluate the probabilities of a disease state, ideally all subjects in a study should be diagnosed by a definitive diagnostic or gold standard test. However, since definitive diagnostic tests are often invasive and expensive, it is generally unethical to apply them to subjects whose screening tests are negative. In this article, we consider latent class models for screening studies with two imperfect binary diagnostic tests and a definitive categorical disease status measured only for those with at least one positive screening test. Specifically, we discuss a conditional independent and three homogeneous conditional dependent latent class models and assess the impact of misspecification of the dependence structure on the estimation of disease category probabilities using frequentist and Bayesian approaches. Interestingly, the three homogeneous dependent models can provide identical goodness-of-fit but substantively different estimates for a given study. However, the parametric form of the assumed dependence structure itself is not “testable” from the data, and thus the dependence structure modeling considered here can only be viewed as a sensitivity analysis concerning a more complicated non-identifiable model potentially involving heterogeneous dependence structure. Furthermore, we discuss Bayesian model averaging together with its limitations as an alternative way to partially address this particularly challenging problem. The methods are applied to two cancer screening studies, and simulations are conducted to evaluate the performance of these methods. In summary, further research is needed to reduce the impact of model misspecification on the estimation of disease prevalence in such settings.