cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Technology Transfer Alliance Collaboration Platform (TTA)
Creators: name: Rwegasira, Diana
Publisher: name: Sci-GaIA Open Access Repository
Year: 2016

description: The poster describes the architecture of one of the Sci-GaIA project "champion" use cases proposed for the e-Research Summer Hackfest (see http://www.sci-gaia.eu/summer-hackfest). The use case regards the development and deployment of the Collaboration Platform of the Technology Transfer Alliance (TTA). The TTA is a non-for-profit network of universities interested in: (i) having an impact on development of the societies in which they exist; (ii) problem-oriented, project-driven learning with a focus on innovation and entrepreneurship; and (iii) offering students and faculty members opportunities to contribute to important projects for academic credit. The Collaboration Platform is intended to be a web-based environment (a Science Gateway), containing an integrated set of tools, applications and data repositories, to support collaboration and training in order to foster project-driven education among the partners of the alliance. The poster has been presented at the Sci-GaIA Workshop on "Open Science in Support of Education", which was held in Dar es Salaam (Tanzania) on the 5th of September 2016 (see http://agenda.ct.infn.it/e/sci-gaia-third-workshop).
EXPERIMENTAL STUDY OF THE GEOMETRIC CHANGES AND EVAPORATION KINETICS OF A LIQUID DROPLET UNDER TEMPERATURE CONDITIONS (USING DISTILLED WATER AS AN EXAMPLE)
Creators: name: Ikromjon Madaminov Lecturer, Department of Physics, Fergana State University
Publisher: name: Zenodo
Year: 2025

description: This article presents an experimental study of the evaporation kinetics and geometric parameter changes — specifically the base diameter and height — of a distilled water droplet in a horizontal configuration under various temperature conditions (21°C, 23°C, 25°C, 27°C, and 29°C). The experiments were conducted under normal atmospheric pressure and 20% relative humidity, with droplet size measurements recorded every minute using an electron microscope. The results demonstrated that with increasing temperature, the evaporation rate of the droplet increased, accompanied by significant changes in the dynamics of its geometric dimensions. Graphical and tabular analyses confirmed an almost linear relationship between temperature and evaporation time. The experimental findings provide an important theoretical and practical basis for a deeper understanding of droplet evaporation mechanisms and for modeling the effects of temperature parameters.
Canadian Pacific Steamships agent's stubs
Creators: name: Yip Sang Company
name: Canadian Pacific Steamships
Publisher: name: The University of British Columbia
Year: 2016

description: Ticket stubs for the following passengers: Mark Yin Hip, Ko Guey Hing, Lim Yow Hen, Lim Woo Ming, Jang Gim Mee, Jang Wah Hin, Jan Wing Shew, Wang Kwock Pon, Lim Yin Gee, Yip Yuey Lung.
Primordial Black Holes from CDM Isocurvature Perturbations
Creators: name: Passaglia, Samuel
name: Sasaki, Misao
Publisher: name: arXiv
Year: 2021
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We show that primordial black holes can be produced from the collapse of large isocurvature perturbations of the cold dark matter. We develop a novel procedure to compute the resulting black hole abundance by studying matched perturbations of matter-only universes, and we use our procedure to translate observational constraints on black hole abundances into model-independent constraints on cold dark matter isocurvature perturbations over a wide range of scales. The constraint on the typical amplitude of the primordial perturbations weakens slightly slower than linearly on small scales.
description: 11 pages, 5 figures
Helicobacter pylori Growth Stage Determines the Size, Protein Composition, and Preferential Cargo Packaging of Outer Membrane Vesicles
Creators: name: Zavan, Lauren
name: Bitto, Natalie
name: Johnston, Ella
name: Greening, David
name: Liaskos, Maria
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Gram-negative bacteria release outer membrane vesicles (OMVs) as part of their normal growth that contain a range of cargo from their parent bacterium, including DNA, RNA, and proteins. The protein content of OMVs is suggested to be similar in composition to various sub-cellular locations of their parent bacterium. However, very little is known regarding the effect of bacterial growth stage on the size, content, and selective packaging of proteins into OMVs. In this study, the global proteome of Helicobacter pylori and their OMVs throughout bacterial growth are examined to determine if bacterial growth stage affected OMV cargo composition. Analysis of OMVs produced by H. pylori reveals that bacterial growth stage affects the size, composition, and selection of protein cargo into OMVs. Proteomic analysis identifies that the proteome of H. pylori OMVs is vastly different throughout bacterial growth and that OMVs contain a range of proteins compared to their parent bacteria. In addition, bacterial growth stage affects the ability of OMVs to induce the production of IL-8 by human epithelial cells. Therefore, the findings identify that the size, proteome, and immunogenicity of OMVs produced during various stages of bacterial growth is not comparable. Collectively, these findings highlight the importance of considering the bacterial growth stage from which OMVs are isolated, as this will impact their size, protein composition, and ultimately their biological functions.
Canadian Pacific Steamships agent's stubs
Creators: name: Yip Sang Company
name: Canadian Pacific Steamships
Publisher: name: The University of British Columbia
Year: 2016

description: Ticket stubs for the following passengers: Jang Hing, Hong Hung, Chan Man Chun, Lee Gin Nan, Jew Loong Joo, Yee Tan, Ng Sair Chun, Lew Chee, Lam Suey Hee, Fong Dap.
preCICE v2: A Sustainable and User-Friendly Coupling Library
Creators: name: Chourdakis, Gerasimos
name: Davis, Kyle
name: Rodenberg, Benjamin
name: Schulte, Miriam
name: Simonis, Frédéric
name: Uekermann, Benjamin
name: Abrams, Georg
name: Bungartz, Hans-Joachim
name: Yau, Lucia Cheung
name: Desai, Ishaan
name: Eder, Konrad
name: Hertrich, Richard
name: Lindner, Florian
name: Rusch, Alexander
name: Sashko, Dmytro
name: Schneider, David
name: Totounferoush, Amin
name: Volland, Dominik
name: Vollmer, Peter
name: Koseomur, Oguz Ziya
Publisher: name: arXiv
Year: 2021
Subjects: subject: Mathematical Software (cs.MS)
subject: FOS: Computer and information sciences

description: preCICE is a free/open-source coupling library. It enables creating partitioned multi-physics simulations by gluing together separate software packages. This paper summarizes the development efforts in preCICE of the past five years. During this time span, we have turned the software from a working prototype -- sophisticated numerical coupling methods and scalability on ten thousands of compute cores -- to a sustainable and user-friendly software project with a steadily-growing community. Today, we know through forum discussions, conferences, workshops, and publications of more than 100 research groups using preCICE. We cover the fundamentals of the software alongside a performance and accuracy analysis of different data mapping methods. Afterwards, we describe ready-to-use integration with widely-used external simulation software packages, tests and continuous integration from unit to system level, and community building measures, drawing an overview of the current preCICE ecosystem.
description: added missing author, added author contributions, changed license
Helicobacter pylori Growth Stage Determines the Size, Protein Composition, and Preferential Cargo Packaging of Outer Membrane Vesicles
Creators: name: Zavan, Lauren
name: Bitto, Natalie
name: Johnston, Ella
name: Greening, David
name: Liaskos, Maria
Publisher: name: La Trobe
Year: 2023

description: No description supplied
OIKODOMOS: Comparative study of virtual and physical studios
Creators: name: Joklova, Viera
name: Riddy, Paul
Publisher: name: Zenodo
Year: 2019
Subjects: subject: Architecture
subject: FOS: Civil engineering
subject: Architecture
subject: Housing
subject: urban studies
subject: Environmental sustainability
subject: Education
subject: Learning
subject: Innovation
subject: Educational Technology/education

description: This report reviews the WP activities including:- the analysis on virtual education in architecture and urban design, in the scope of the Design Studios;- the specification of Virtual Design Studios and the comparison of virtual and physical aspects in the Design Studio education;- the valorization of realized VDS pedagogic models, identification of strong and weak points, opportunities and threats of their further development.
title: Intrinsic Diversity in Hippocampal Neurons: Phenomenological and Integrative Descriptions of Quantitative Dynamics
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2020

description: Simulations of neural systems promise to offer powerful frameworks to formulate and test hypotheses about the physical interactions intrinsic to the brain. A comprehensive characterization of experimentally observed neuronal diversity using a modeling system is necessary to simulate biologically realistic brain networks at the cell type level. Biophysically detailed model descriptions typically limit the scalability of such network simulations as they specify hundreds of equations governing each neuron’s intrinsic dynamics. On the other hand, simple phenomenological models, which compactly describe the patterns of neuronal excitability through dynamical bifurcations, often lack experimentally identifiable parameters. This makes it challenging for such models to quantitatively account for the intrinsic diversity experimentally observed among the neurons. In this work, compact model descriptions that comprehensively capture the intrinsic dynamical diversity observed among the rodent hippocampal neurons are created. Both point-neuron and compact multi-compartment models are optimized using evolutionary algorithms. These optimized models reflect the intrinsic differences among hippocampal neuron types both qualitatively and quantitatively. In addition, this work describes the collective dynamics of an ensemble of bursting neurons based on their self-organizing properties. Measures are formulated to quantify the metastable nature of the neural ensembles. Such integrative descriptions of neuronal dynamics can complement their intrinsic descriptions to accurately simulate biological neural circuits.
Canadian Pacific Steamships agent's stubs
Creators: name: Yip Sang Company
name: Canadian Pacific Steamships
Publisher: name: The University of British Columbia
Year: 2016

description: Ticket stubs for the following passengers: Mah Bow, Seto Gay Kuey, Fong Jim Sing, Fong Lung Goey, Jay Young, Kuron Foon Gin, Wong Fon, Wong Gee, Wong Wing Kong, Mah Sing.
Capacidad cariogénica de la Candida albicans: Estudio in vitro, Arequipa 2024
Creators: name: Paniagua Caira, Daniela Giuliana
Publisher: name: Universidad Católica de Santa María
Year: 2024
Subjects: Candida albicans
Streptococcus Mutans

description: La Candida albicans es uno de los microorganismos que hospedan la cavidad bucal en la mayoría de individuos sanos e inmunocomprometidos colonizando sitios mucosos y también han sido aislados con alta frecuencia en lesiones de caries en niños; muy pocos estudios enfocan el papel que desempeña la Candida albicans en la patogenicidad del biofilm debido a que la mayoría de estudios mencionan que la Cándida albicans solo es responsable de potenciar la cariogénicidad del Streptococcus Mutans. El presente trabajo de investigación tiene como objetivo evaluar la capacidad cariogénica de la Candida albicans en un estudio in vitro. La investigación se realizó en 12 discos de piezas de bovino de 1cm de diámetro, divididos en 4 grupos, 3 sub grupos y también la cepa del microorganismo de Candida albicans; cada grupo está conformado por 3 discos. Los discos fueron colocados en una placa de tejidos de 6 pocillos en grupos de 3, previamente el microorganismo Candida albicans fue incubado y reactivado en Agar Sabouraud. En una placa Petri se colocó 80 uL del microorganismo sobre nueve de los discos (Escala 0.5 MacFarland) y se dejó 60 minutos a 37° en la estufa. Después de eso, se trasladó a una placa de cultivo de 6 pocillos dividiéndolos en los grupos correspondientes y añadiendo al control negativo que no fue inoculado, los grupos fueron divididos por días de control, retirando 2 discos de cada grupo y utilizando el indicador de caries Sable Seek realizando la tinción para su posterior vista microscópica; 1 disco de cada grupo es sometido a microscopia electrónica de barrido. Finalmente, los datos se procesaron utilizando ANOVA bidireccional con la prueba post hoc de Tukey y el valor de P<0.001 se consideró estadísticamente significativo. Los datos mostraron que Candida albicans es capaz de desarrollar caries sin la presencia de ningún microorganismo cariogénico; las diferencias significativamente mayores se evidencian entre los días 7-14 en donde se observa un aumento de área revelada en un 35% interpretando como pico a los primeros 14 días y posterior a ellos se observan cambios, pero no con tanta magnitud. Podemos concluir que la Candida albicans posee capacidad cariogénica, desmineralizando al esmalte dental, por lo tanto, no es solo un patógeno que afecta únicamente a la mucosa de la cavidad bucal, sino que también afecta a los tejidos duros del diente. La importancia clínica que presenta esta investigación revela la importancia de un nuevo enfoque en los tratamientos que en la actualidad se tienen para combatir a la enfermedad de caries; esto debido a que la Candida albicans es un patógeno con la capacidad de provocar caries dental y debe ser incluido en uno de los agentes causales de la caries.
Staff perspectives of a model of access and triage for reducing waiting time in ambulatory services: a qualitative study
Creators: name: Harding, Katherine
name: Snowdon, David
name: Lewis, Annie
name: Leggat, Sandra
name: Kent, Bridie
name: Watts, Jennifer J
name: Taylor, Nicholas
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 4205
subject: Nursing
classificationCode: 4206
subject: Public health

description: Background: Specific Timely Appointments for Triage (STAT) is an intervention designed to reduce waiting time in community outpatient health services, shown to be effective in a large stepped wedge cluster randomised controlled trial. STAT combines initial strategies to reduce existing wait lists with creation of a specific number of protected appointments for new patients based on demand. It offers an alternative to the more traditional methods of demand management for these services using waiting lists with triage systems. This study aimed to explore perceptions of clinicians and administrative staff involved in implementing the model. Method: Semi-structured interviews with 20 staff members who experienced the change to STAT were conducted by an independent interviewer. All eight sites involved in the original trial and all professional disciplines were represented in the sample. Data were coded and analysed thematically. Results: Participants agreed that shorter waiting time for patients was the main advantage of the STAT model, and that ongoing management of caseloads was challenging. However, there was variation in the overall weight placed on these factors, and therefore the participants' preference for the new or previous model of care. Perceptions of whether the advantages outweighed the disadvantages were influenced by five sub-themes: staff perception of how much waiting matters to the patient, prior exposure to the management of waiting list, caseload complexity, approach and attitude to the implementation of STAT and organisational factors. Conclusions: The STAT model has clear benefits but also presents challenges for staff members. The findings of this study suggest that careful preparation and management of change and active planning for known fluctuations in supply and demand are likely to help to mitigate sources of stress and improve the likelihood of successful implementation of the STAT model for improving waiting times for patients referred to community outpatient services.
Coupled interaction between acoustics and unsteady flame dynamics during the transition to thermoacoustic instability in a multi-element rocket combustor
Creators: name: Kasthuri, Praveen
name: Pawar, Samadhan A.
name: Gejji, Rohan
name: Anderson, William
name: Sujith, R. I.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Rocket engine combustors are prone to transverse instabilities that are characterized by large amplitude high frequency oscillations in the acoustic pressure and the heat release rate. We study the coupled interaction between the acoustic pressure and the CH* intensity oscillations in a 2D multi-element self-excited model rocket combustor during the transition from a stable state to thermoacoustic instability through intermittency. We show the emergence of synchronization between these oscillations from desynchronization through intermittent phase synchronization during the onset of thermoacoustic instability. We find substantial evidence that the intensities of the jet flames close to the end wall is higher than that observed near the center of the combustor as a result of its strong coupling to the local acoustic field. Using concepts from recurrence theory, we distinguish the type of synchronization between the acoustic pressure and the CH* intensity oscillations at the end wall and the center of the combustor during thermoacoustic instability. Analyzing the local CH* intensity oscillations, we observe that the longitudinally propagating jet flames experience substantial transverse displacement with flame merging effects during thermoacoustic instability. Furthermore, we differentiate the interaction of the jet flames with the shock wave during intermittency and thermoacoustic instability at both the end wall and the center of the combustor. We also discerned the change from stochastic to deterministic nature in the local CH* intensity oscillations during the transition to thermoacoustic instability. Our results demonstrate that only the first few transverse modes contribute to the generation of acoustic power from the reacting flow, in spite of the pressure oscillations featuring several harmonics.
title: Community Newspapers
Creators: name: Dilts, Russell
name: Fikih, Mansour
Publisher: name: University of Massachusetts Amherst
Year: 1989
Subjects: subject: Education

description: This Technical Note is derived from the field experience of its authors in Indonesia working for a various non-government, private volunteer organizations.
description: Summary: This note presents a simple, easily utilized approach to creating and publishing a village-level newspaper. The process emphasizes the participatory nature of the product and provides useful tips which the reader can use to help create village newspapers.
K-Splits: Improved K-Means Clustering Algorithm to Automatically Detect the Number of Clusters
Creators: name: Mohammadi, Seyed Omid
name: Kalhor, Ahmad
name: Bodaghi, Hossein
Publisher: name: arXiv
Year: 2021
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: This paper introduces k-splits, an improved hierarchical algorithm based on k-means to cluster data without prior knowledge of the number of clusters. K-splits starts from a small number of clusters and uses the most significant data distribution axis to split these clusters incrementally into better fits if needed. Accuracy and speed are two main advantages of the proposed method. We experiment on six synthetic benchmark datasets plus two real-world datasets MNIST and Fashion-MNIST, to prove that our algorithm has excellent accuracy in finding the correct number of clusters under different conditions. We also show that k-splits is faster than similar methods and can even be faster than the standard k-means in lower dimensions. Finally, we suggest using k-splits to uncover the exact position of centroids and then input them as initial points to the k-means algorithm to fine-tune the results.
description: 16 pages, 6 figures
Canadian Pacific Steamships agent's stubs
Creators: name: Yip Sang Company
name: Canadian Pacific Steamships
Publisher: name: The University of British Columbia
Year: 2016

description: Ticket stubs for the following passengers: Wong King Fong, Lim Mon Chun, Lee Soon, Soon Wah Bing, Chin Kam Moon, Chin Chew Bong, Wong Bing Fon, Chan Soot, Chan Yat, Mah Toon Fon.
Challenges for sport organisations developing and delivering non-traditional social sport products for insufficiently active populations
Creators: name: Staley, Kiera
name: Donaldson, Alex
name: Randle, Erica
name: Nicholson, Matthew
name: O'Halloran, Paul
name: Nelson, Rayoni
name: Cameron, Matthew
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4202
subject: Epidemiology
classificationCode: 4203
subject: Health services and systems
classificationCode: 4206
subject: Public health

description: Objectives: To explore the challenges that Victorian sporting organisations experience when developing, delivering or scaling non-traditional social sport products to engage insufficiently active people. Methods: Online Concept Mapping was used to gather qualitative data and analyse it quantitatively. Results: A total of 68 participants (27 organisations) brainstormed 158 challenges. The research team synthesised these to 71 unique challenges for participants to sort into groups and rate for importance (0–5) and ease of overcoming (0–5). A nine-cluster solution – Deliverers; Capacity to drive the product; Facilities and partnerships; Product development; Sustainable business model; Marketing to insufficiently active; Attracting the insufficiently active; Clubs and volunteers; and Shifting traditional sport culture – was considered most appropriate. Participants rated the Deliverers challenges as the most important (mean=3.52), and the Marketing to insufficiently active challenges as the easiest to overcome (2.72). Conclusions: Key ingredients to successfully developing and delivering non-traditional sport opportunities for insufficiently active populations are: recruiting appropriate product deliverers; building the capacity of delivery organisations and systems; and developing products relevant to the delivery context that align with the needs and characteristics of the target population. Implications for public health: A system-wide response is required to address the challenges associated with sport organisations developing, scaling and delivering innovative social sport products for insufficiently active populations.
Relación entre los aspectos clínicos de la melanosis gingival fisiológica y de la melanosis de otras áreas de la mucosa oral en pacientes de la Consulta Privada. Arequipa, 2023
Creators: name: Choque Zúniga, Rody
Publisher: name: Universidad Católica de Santa María
Year: 2024
Subjects: Melanosis gingival
Melanosis de la mucosa oral

description: El presente estudio tiene por objeto relacionar la melanosis gingival fisiológica con la melanosis de otras áreas de la mucosa oral en pacientes de la consulta privada. Se trata de una investigación observacional, prospectiva, transversal y descriptiva, de nivel relacional, en que las variables fueron analizadas mediante la técnica de observación clínica intraoral en 41 pacientes con melanosis gingival fisiológica, a partir de una p = 0.40; una W = 0.30, y un nivel de confianza de 95%. La técnica fue operativizada a través de la aplicación de un instrumento estructurado denominado ficha de registro, con la que se obtuvo información que luego fue procesada y tratada estadísticamente por medio de frecuencias absolutas y porcentuales debido al carácter categórico de las variables. La relación fue evaluada por medio del contraste X2. Los hallazgos indicaron predominancia de la melanosis gingival leve con el 53.66% ubicada mayormente en vestibular anterosuperior con el 63.41%, así como preeminencia de la melanosis del dorso lingual con el 41.46%. De acuerdo al contraste X2, no existe relación estadística significativa entre melanosis gingival y melanosis en otras áreas de la mucosa oral, por lo que se acepta la hipótesis nula con un nivel de significación de p > 0.05.
Diaminomaleonitrile-Functionalised Schiff Bases: Synthesis, Solvatochromism, and Lysosome-Specific Imaging
Creators: name: Ding, Siyang
name: Yao, Bicheng
name: Chen, MZ
name: Liu, Chuanxin
name: Owyong, Tze Cin
name: Johnston, A
name: Hong, Yuning
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences
classificationCode: 3403
subject: Macromolecular and materials chemistry
classificationCode: 40
subject: Engineering

description: The design of novel organic fluorescent molecules with aggregation-induced emission (AIE) properties has been a research focus in the past two decades. In this work, we report the photophysical studies and potential applications of a series of AIE-active luminogens based on a small building block, a diaminomaleonitrile Schiff base. By taking advantage of easily approachable synthetic procedures and excellent optical properties of this system, we further explored the applications of this system for cell imaging.
Canadian Pacific Steamships agent's stubs
Creators: name: Yip Sang Company
name: Canadian Pacific Steamships
Publisher: name: The University of British Columbia
Year: 2016

description: Ticket stubs for the following passengers: Chow Him, [Chow Chew Keep], Chin Guy, Wong Kee Jong, Yee Chong, Mack Chew Wing, [Mark Se Fun], [Chan Jon Houre], Wong Sic Chew, Yee Yoke Foo.
Diaminomaleonitrile-Functionalised Schiff Bases: Synthesis, Solvatochromism, and Lysosome-Specific Imaging
Creators: name: Ding, Siyang
name: Yao, Bicheng
name: Chen, MZ
name: Liu, Chuanxin
name: Owyong, Tze Cin
name: Johnston, A
name: Hong, Yuning
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: The design of novel organic fluorescent molecules with aggregation-induced emission (AIE) properties has been a research focus in the past two decades. In this work, we report the photophysical studies and potential applications of a series of AIE-active luminogens based on a small building block, a diaminomaleonitrile Schiff base. By taking advantage of easily approachable synthetic procedures and excellent optical properties of this system, we further explored the applications of this system for cell imaging.
Canadian Pacific Steamships agent's stubs
Creators: name: Yip Sang Company
name: Canadian Pacific Steamships
Publisher: name: The University of British Columbia
Year: 2016

description: Ticket stubs for the following passengers: Tom Lung Sing, [Young Doo Ling], [Young Gin Yuen], Young Yee Lap, Wong Sai Yee, Yew Gow, Tom Yong Lun, Chin Buck Hing, Mah Sen Lum, Mark Shew Bing.
Targeting triple-negative breast cancers with the Smac-mimetic birinapant
Creators: name: N Lalaoui
name: Merino, Delphine
name: G Giner
name: F Vaillant
name: D Chau
name: L Liu
name: T Kratina
name: Pal, Bhupinder
name: JR Whittle
name: Etemadi, Nima
name: Berthelet, Jean
name: J Gräsel
name: C Hall
name: ME Ritchie
name: Ernst, Matthias
name: GK Smyth
name: Vaux, David
name: JE Visvader
name: GJ Lindeman
name: Silke, John
Publisher: name: La Trobe
Year: 2020
Subjects: Uncategorized

description: © 2020, The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare. Smac mimetics target inhibitor of apoptosis (IAP) proteins, thereby suppressing their function to facilitate tumor cell death. Here we have evaluated the efficacy of the preclinical Smac-mimetic compound A and the clinical lead birinapant on breast cancer cells. Both exhibited potent in vitro activity in triple-negative breast cancer (TNBC) cells, including those from patient-derived xenograft (PDX) models. Birinapant was further studied using in vivo PDX models of TNBC and estrogen receptor-positive (ER+) breast cancer. Birinapant exhibited single agent activity in all TNBC PDX models and augmented response to docetaxel, the latter through induction of TNF. Transcriptomic analysis of TCGA datasets revealed that genes encoding mediators of Smac-mimetic-induced cell death were expressed at higher levels in TNBC compared with ER+ breast cancer, resulting in a molecular signature associated with responsiveness to Smac mimetics. In addition, the cell death complex was preferentially formed in TNBCs versus ER+ cells in response to Smac mimetics. Taken together, our findings provide a rationale for prospectively selecting patients whose breast tumors contain a competent death receptor signaling pathway for the further evaluation of birinapant in the clinic.
Supernova Preshock Neutronization Burst as a Probe of Non-Standard Neutrino Interactions
Creators: name: Huang, Xu-Run
name: Zha, Shuai
name: Chen, Lie-Wen
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Core-collapse supernova (CCSN) provides a unique astrophysical site for studying neutrino-matter interactions. Prior to the shock-breakout neutrino burst during the collapse of the iron core, a preshock $ν_e$ burst arises from the electron capture of nuclei and it is sensitive to the low-energy coherent elastic neutrino-nucleus scattering (CE$ν$NS) which dominates the neutrino opacity. Since the CE$ν$NS depends strongly on the non-standard neutrino interactions (NSI) which are completely beyond the standard model and yet to be determined, the detection of the preshock burst thus provides a clean way to extract the NSI information. Within the spherically symmetric general-relativistic hydrodynamic simulation for the CCSN, we investigate the NSI effects on the preshock burst. We find that the NSI can maximally enhance the peak luminosity of the preshock burst almost by a factor of three, reaching a value comparable with that of the shock-breakout burst. Future detection of the preshock burst will have critical implications on astrophysics, neutrino physics and physics beyond the standard model.
description: 7 pages, 3 figures. Presentation improved and discussions added. Accepted version to appear in ApJL
Exosomes derived from the human primary colorectal cancer cell line SW480 orchestrate fibroblast‐led cancer invasion
Creators: name: Rai, Alin
name: Greening, David
name: Xu, Rong
name: Wittaya Suwakulsiri
name: Simpson, Richard
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim In localized tumors, basement membrane (BM) prevents invasive outgrowth of tumor cells into surrounding tissues. When carcinomas become invasive, cancer cells either degrade BM or reprogram stromal fibroblasts to breach BM barrier and lead invasion of cancer cells into surrounding tissues in a process called fibroblast-led invasion. However, tumor-derived factors orchestrating fibroblast-led invasion remain poorly understood. Here it is shown that although early-stage primary colorectal adenocarcinoma (SW480) cells are themselves unable to invade Matrigel matrix, they secrete exosomes that reprogram normal fibroblasts to acquire de novo capacity to invade matrix and lead invasion of SW480 cells. Strikingly, cancer cells follow leading fibroblasts as collective epithelial-clusters, thereby circumventing need for epithelial to mesenchymal transition, a key event associated with invasion. Moreover, acquisition of pro-invasive phenotype by fibroblasts treated with SW480-derived exosomes relied on exosome-mediated MAPK pathway activation. Mass spectrometry-based protein profiling reveals that cancer exosomes upregulate fibroblasts proteins implicated in focal adhesion (ITGA2/A6/AV, ITGB1/B4/B5, EGFR, CRK), regulators of actin cytoskeleton (RAC1, ARF1, ARPC3, CYFIP1, NCKAP1, ICAM1, ERM complex), and signalling pathways (MAPK, Rap1, RAC1, Ras) important in pro-invasive remodeling of extracellular matrix. Blocking tumor exosome-mediated signaling to fibroblasts therefore represents an attractive therapeutic strategy in restraining tumors by perturbing stroma-driven invasive outgrowth.
Canadian Pacific Steamships agent's stubs
Creators: name: Yip Sang Company
name: Canadian Pacific Steamships
Publisher: name: The University of British Columbia
Year: 2016

description: Ticket stubs for the following passengers: Yee Lung, Lun Chew, Nip Fay, Hong Bark Yee, Nip Yee, Wong Jor, Mah Wing Fon, Mah How Ping, Mah Weing Luon, [Mark Wart Kee].
Exosomes derived from the human primary colorectal cancer cell line SW480 orchestrate fibroblast‐led cancer invasion
Creators: name: Rai, Alin
name: Greening, David
name: Xu, Rong
name: Suwakulsiri, Wittaya
name: Simpson, Richard
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 32
subject: Biomedical and clinical sciences

description: No description supplied
Relational evolution with oscillating clocks
Creators: name: Bojowald, Martin
name: Martinez, Luiz
name: Wendel, Garrett
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A fundamental description of time can be consistent not only with the usual monotonic behavior but also with a periodic physical clock variable, coupled to the degrees of freedom of a system evolving in time. Generically, one would in fact expect some kind of oscillating motion of a system that is dynamical and interacts with its surroundings, as required for a fundamental clock that can be noticed by any other system. Unitary evolution does not require a monotonic clock variable and can be achieved more generally by formally unwinding the periodic clock movement, keeping track not only of the value of the clock variable but also of the number of cycles it has gone through at any moment. As a result, the clock is generically in a quantum state with a superposition of different clock cycles, a key feature that distinguishes oscillating clocks from monotonic time. Because the clock and an evolving system have a common conserved energy, the clock is in different cycles for different energy eigenstates of the system state. Coherence could therefore be lost faster than observed, for instance if a system that would be harmonic in isolation is made anharmonic by interactions with a fundamental clock, implying observational bounds on fundamental clocks. Numerical computations show that coherence is almost maintained over long time scales provided the clock period is much smaller than the system period. Since the precision of atomic clocks could not be achieved if atomic frequencies would be subject to additional variations from coupling to a fundamental clock, an upper bound on the clock period can be obtained that turns out to be much smaller than currently available direct or indirect measurements of time. (abbreviated)
description: 33 pages, 11 figures
Responsiveness of the single item measure to detect change in physical activity
Creators: name: O'Halloran, Paul
name: Kingsley, Michael
name: Nicholson, Matthew
name: Staley, Kiera
name: Randle, Erica
name: Wright, Annemarie
name: Bauman, Adrian
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 39
subject: Education
classificationCode: 3901
subject: Curriculum and pedagogy
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4206
subject: Public health

description: Objective The objective of this study was to evaluate the responsiveness of the single item measure (SIM) to detect change in PA when compared to hip-worn accelerometry. A secondary aim was to provide further data on validity of the measure at a single time point. Methods Validity of the SIM to determine the number of days of ≥30 minutes of accelerometer-derived moderate-to-vigorous physical activity (MVPA) was assessed in 120 participants (78% female, 19% male, 3% other; age: 46 ± 11 years). Analysis of change was based on change in the number of days that participants completed ≥30 minutes of MVPA determined by the SIM and accelerometry over two 7-day periods in 90 participants (age: 47±11 years). Accelerometer data were analysed as total minutes of MVPA per day (MVPA-total) and as sustained bouts of 10 minutes or more of MVPA (MVPA-bouts). Validity of the SIM to detect change in MVPA, using accelerometer data as the reference measurement, was examined through Spearman’s correlation and agreement in classification of change between SIM and accelerometry. Responsiveness to change was assessed by standardised response means and Cohen’s d. Results Standardised response means for PA change were moderate for the SIM (0.77), MVPA-total (0.57) and MVPA-bouts (0.79). The correlation for change in number of days ≥30 minutes MVPA between the SIM and accelerometry were small to moderate (MVPA-total: r = 0.36 and MVP-bouts: r = 0.40). The SIM displayed moderate accuracy (60%-63%), using accelerometer data as the reference measurement, in detecting increases in days ≥30 minutes of MVPA. Conclusion The SIM is a potentially useful assessment tool for evaluating change in MVPA, particularly when device-based measures or longer self-report measures are not feasible.
The eROSITA Final Equatorial-Depth Survey (eFEDS): X-ray Properties and Scaling Relations of Galaxy Clusters and Groups
Creators: name: Bahar, Y. Emre
name: Bulbul, Esra
name: Clerc, Nicolas
name: Ghirardini, Vittorio
name: Liu, Ang
name: Nandra, Kirpal
name: Pacaud, Florian
name: Chiu, I-Non
name: Comparat, Johan
name: Ider-Chitham, Jacob
name: Klein, Mathias
name: Liu, Teng
name: Merloni, Andrea
name: Migkas, Konstantinos
name: Okabe, Nobuhiro
name: Ramos-Ceja, Miriam E.
name: Reiprich, Thomas H.
name: Sanders, Jeremy S.
name: Schrabback, Tim
Publisher: name: arXiv
Year: 2021
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We investigate the scaling relations between X-ray observables of the clusters detected in the eFEDS field using Spectrum-Roentgen-Gamma/eROSITA observations taking into account the selection effects and the distributions of observables with cosmic time. We extract X-ray observables (Lx, Lbol, T, Mgas, Yx) within R500 for the sample of 542 clusters in the eFEDS field. By applying detection and extent likelihoods, we construct a subsample of 265 clusters with a contamination level of <10% (including AGNs and spurious fluctuations) to be utilized in the scaling relation analysis. The selection function based on the state-of-the-art simulations of the eROSITA sky is fully accounted for in our work. We provide the X-ray observables in the core-included 3sigma confidence level however, our results are in good agreement with the simulations including non-gravitational physics and the recent results that take into account selection effects. Strong deviations we find from the self-similar scenario indicate that the non-gravitational effects play an important role in shaping the observed physical state of clusters. This work extends the scaling relations to low mass, low luminosity galaxy cluster and group regime using eFEDS observations, demonstrating eROSITA's ability to measure ICM emission out to R500 with survey-depth exposures and constrain the scaling relations in a wide mass-luminosity-redshift range.
description: 35 pages, 7 figures, 5 tables, Submitted to A&A for the Special Issue: The Early Data Release of eROSITA and Mikhail Pavlinsky ART-XC on the SRG Mission
title: Policy Brief to the Minister of Finance of Liberia Mme Antoinette Sayeh: What Should Liberia Do to Improve Its Economy and the Well-Being of Its Citizens?
Creators: name: Pyrtel, Mikael M.
name: Sandifer, Kirsten E.
name: Namabiro, Ann D.
Publisher: name: George Mason University
Year: 2007

description: From Volume 1 (2007) of New Voices in Public Policy
description: This policy brief is the result of Professor Todd La Porte issuing a challenge to students as part of an introductory course in the International Commerce and Policy (ICP) program at the George Mason University School of Public Policy. The assignment was to recommend ways in which the country of Liberia, having recently emerged from years of civil war and dictatorship, can strengthen the economy and improve the well-being of its citizens. We accepted the challenge and began researching Liberian history and the current political, economic, and social challenges that Liberia is working to overcome, and some of the development efforts currently underway with multi-lateral institutions. This policy brief begins with an executive summary and makes recommendations for economic growth and improved social well-being by addressing several areas, including fiscal policy, agriculture and rural development, and education.
Canadian Pacific Steamships agent's stubs
Creators: name: Yip Sang Company
name: Canadian Pacific Steamships
Publisher: name: The University of British Columbia
Year: 2016

description: Ticket stubs for the following passengers: Law Doo Lin, Chan Young, Chan On, Lee Yow Kin, Song Chun, Lai Hung Sik, Lai Kin, Fung Bark Kong, Lee Ho, Lee York Kwong.
Dynamical scaling of correlations generated by short- and long-range dissipation
Creators: name: Seetharam, Kushal
name: Lerose, Alessio
name: Fazio, Rosario
name: Marino, Jamir
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study the spatio-temporal spreading of correlations in an ensemble of spins due to dissipation characterized by short- and long-range spatial profiles. We consider systems initially in an uncorrelated state, and find that correlations widen and contract in a novel pattern intimately related to both the dissipative nature of the dynamical channel and its spatial profile. Additionally, we make a methodological contribution by generalizing non-equilibrium spin-wave theory to the case of dissipative systems and derive equations of motion for any translationally invariant spin chain whose dynamics can be described by a combination of Hamiltonian interactions and dissipative Lindblad channels. Our work aims at extending the study of correlation dynamics to purely dissipative quantum simulators and compare them with the established paradigm of correlations spreading in hamiltonian systems.
description: 10 pages, 2 figures, builds on topic introduced in arXiv:2101.06445v2
Supplementary document for Vacuum-assisted tissue embedding for whole-heart imaging - 6402778.pdf
Creators: name: Wang, Zhi
name: Xie, ruiheng
name: Shi, Qishuo
name: Li, Yafeng
name: chang, jin
name: Yuan, Jing
name: Gong, Hui
name: Chen, Jianwei
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Fig. S1, S2, S3
KEŃESBAY RAXMANOVTIŃ POEZYALIQ SHIǴARMALARINDA QOLLANILǴAN LEKSIKALIQ ANTONIMLERDIŃ ÓZGESHELIKLERI
Creators: name: Perdebaeva, Gúlxatisha
Publisher: name: Zenodo
Year: 2024

description: Biz K.Raxmanov shıǵarmalarındaǵı antonimlerdi tallay otırıp, olardıń leksikalıq, kontekstlik, grammatikalıq túrleriniń de qollanǵanlıǵın kórdik.
title: Consonant Sound Symbolism in Dietary Supplement Product Names
Creators: name: Shenkar, Julia
Publisher: name: George Mason University
Year: 2019
Subjects: subject: Sound symbolism
subject: Product marketing
subject: Consonant clusters
subject: Dietary supplements
subject: Branding
subject: Phonoaesthemes

description: The linguistic term “sound symbolism” refers to the inherent sound-to-meaning correspondences that appear to exist in language. According to sound symbolic theory, minimal elements of language, such as phonemes and syllables, are capable of evoking larger concepts usually communicated through complete lexical items. In other words, the mere sounds that make up a language can evoke feelings, impressions of attributes such as size, gender, and color, or abstract ideas. As such, sound symbolism is often employed in the creation of product names to enhance marketing efforts and to emphasize product qualities or intended purpose. This study examines sound symbolism in dietary supplement product names, particularly focusing the possible English C/l/ clusters (bl, fl, gl, kl, pl, sl), and the corresponding singletons (b, f, g, k, p, s). In this study, 261 participants were asked to rank possible names for two fictional dietary supplement products: a joint health supplement and a hair, skin, and nails supplement. Product names varied in word-initial onset (C/l/ or C), as well as two possible endings, one based on the product’s main ingredient and the other based on the product’s marketed benefit, respectively. Each ending was paired with each onset (C/l/+ingredient, C/l/+benefit, C+ingredient, and C+benefit), resulting in a total of 24 possible names. Participants ranked names, presented in four groups of six for each product, and ultimately selected the best name from their top choices. Results show that, although phonetic symbolism was certainly a motivator of choice, consumers, when primed with a marketing claim, will more frequently pull associations from the inventories of their established lexicons, rather than their phonological inventories.
WIMEA-ICT WRF Portal
Creators: name: Damas Makweba
name: Triphonia Ngailo
Publisher: name: Sci-GaIA Open Access Repository
Year: 2016

description: The poster describes the architecture of one of the Sci-GaIA project "champion" use cases proposed for the e-Research Summer Hackfest (see http://www.sci-gaia.eu/summer-hackfest). The use case regards the integration of the Weather Research and Forecasting Model (WRF) in the Africa Grid Science Gateway to be (primarily) used by the WIMEA-ICT project and exploiting the High Performance Computing (HPC) resources at the Dar es Salaam Institute of Technology. Weather information is vital for decision making in various domains, such as agriculture, disaster management, aviation, fishing, energy, mining, construction, defense, water resources, health, etc., and  WRF is a next-generation mesoscale numerical weather prediction system designed for both atmospheric research and operational forecasting needs. The poster has been presented at the Sci-GaIA Workshop on "Open Science in Support of Education", which was held in Dar es Salaam (Tanzania) on the 5th of September 2016 (see http://agenda.ct.infn.it/e/sci-gaia-third-workshop).
Large Language Models: An Introduction for Life Scientists
Creators: name: Haase, Robert
Publisher: name: Zenodo
Year: 2024

description: Large Language Models (LLMs) are changing the way how humans interact with computers. This has impact on all scientific fields by enabling new ways to achieve for example data analysis goals. In this talk we will go through an introduction to LLMs with respect to applications in the life sciences, focusing on bio-image analysis. We will see how to generate text and images using LLMs and how LLMs can extract information from reproducibly images through code-generation. We will go through selected prompt engineering techniques enabling scientists to tune the output of LLMs towards their scientific goal and how to do quality assurance in this context.