cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Activation Thermodynamics of Poly(Ethylene Glycol)-Mediated Model Membrane Fusion Support Mechanistic Models of Stalk and Pore Formation
Creators: name: Tarafdar, Pradip K.
name: Sengupta, Tanusree
name: Lentz, Barry R.
name: Chakraborty, Hirak
name: Bruno, Michael J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Membrane fusion, essential to eukaryotic life, is broadly envisioned as a three-step process proceeding from contacting bilayers through two semistable, nonlamellar lipidic intermediate states to a fusion pore. Here, we introduced a new, to our knowledge, experimental approach to gain insight into the nature of the transition states between initial, intermediate, and final states. Recorded time courses of lipid-mixing, content-mixing, and content-leakage associated with fusion of 23 nm vesicles in the presence of poly(ethylene glycol) at multiple temperatures were fitted globally to a three-step sequential model to yield rate constants and thereby activation thermodynamics for each step of the process, as well as probabilities of occurrence of lipid-mixing, content-mixing, or content-leakage in each state. Experiments with membranes containing hexadecane, known to reduce interstice energy in nonlamellar structures, provided additional insight into the nature of fusion intermediates and transition states. The results support a hypothesis for the mechanism of stalk formation (step-1) that involves acyl chain protrusions into the interbilayer contact region, a hypothesis for a step-2 mechanism involving continuous interconversion of semistable nonlamellar intermediates, and a hypothesis for step-3 (pore formation) mechanism involving correlated movement of whole lipid molecules into hydrophobic spaces created by geometry mismatch between intermediate structures.
(101322) George Walter Leigh
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
An estimation of the willingness to pay for biodiesel: a pilot study of diesel consumers
Creators: name: Sivashankar, Pathmanathan
name: Weerahewa, Jeevika
name: Pushpakumara, Gamini
name: Galagedara, Lakshman
Publisher: name: Bio-based and Applied Economics
Year: 2016

description: Sri Lanka’s energy policy presumes that the country will be meeting 20% of its energy requirements by non-conventional renewable energy resources by 2020. This study attempts to assess diesel vehicle owners’ willingness to pay (WTP) for Jatropha biodiesel and the factors affecting their decisions. The Contingent valuation method (CVM) was used to elicit the WTP for the non-marketed biodiesel, which leads to a hypothetical allocation. For diesel vehicle users, a single bid approach was used at Rs.121/= per litre (€ 0.83). The study was carried out in Kandy region among diesel vehicle users. The factors affecting WTP were estimated using probit regression and WTP was estimated using nonparametric estimation techniques. The mean WTP for biodiesel by the diesel vehicle users was Rs.109 per litre (€ 0.74) for lower bound levels. The median WTP was Rs.124/= per litre (€ 0.85). Elderly respondents with higher education are less likely to pay for biodiesel in both samples. Married respondents with higher income are more likely to pay higher prices for biodiesel.
description: Bio-based and Applied Economics, Vol 5 No 1 (2016)
Structural change and agricultural diversification since China’s reforms
Creators: name: Li, Lihua
name: Bellotti, Bill
name: Komarek, Adam
Publisher: name: Bio-based and Applied Economics
Year: 2016

description: Structural change is considered the major engine in fostering a country’s growth. In the agricultural sector, diversification is the commonly used development strategy to increase rural sector’s flexibility, and to respond to improving technologies and market conditions. This study examined agricultural development and transformation during China’s socio-economic reforms. In particular, it empirically investigated whether the change of China’s agricultural structure is consistent with structural change theory and observed outcomes from other countries. The degree of agricultural diversification was quantitatively measured at a regional scale using the Herfindahl index. An underdeveloped province in northwest China was studied to provide insights into the interaction among structural change, agricultural diversification, and implemented development policies. Aggregate-level analyses suggest that China’s agricultural transformation pattern is consistent with those of other developing countries. A specific provincial-level analysis shows that environmentally and economically disadvantaged regions are slower to diversify their economy than better endorsed regions.
description: Bio-based and Applied Economics, Vol 5 No 2 (2016)
Discrete Molecular Dynamics Distinguishes Nativelike Binding Poses from Decoys in Difficult Targets
Creators: name: Proctor, Elizabeth A.
name: Dokholyan, Nikolay V.
name: Yin, Shuangye
name: Tropsha, Alexander
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Virtual screening is one of the major tools used in computer-aided drug discovery. In structure-based virtual screening, the scoring function is critical to identifying the correct docking pose and accurately predicting the binding affinities of compounds. However, the performance of existing scoring functions has been shown to be uneven for different targets, and some important drug targets have proven especially challenging. In these targets, scoring functions cannot accurately identify the native or near-native binding pose of the ligand from among decoy poses, which affects both the accuracy of the binding affinity prediction and the ability of virtual screening to identify true binders in chemical libraries. Here, we present an approach to discriminating native poses from decoys in difficult targets for which several scoring functions failed to correctly identify the native pose. Our approach employs Discrete Molecular Dynamics simulations to incorporate protein-ligand dynamics and the entropic effects of binding. We analyze a collection of poses generated by docking and find that the residence time of the ligand in the native and nativelike binding poses is distinctly longer than that in decoy poses. This finding suggests that molecular simulations offer a unique approach to distinguishing the native (or nativelike) binding pose from decoy poses that cannot be distinguished using scoring functions that evaluate static structures. The success of our method emphasizes the importance of protein-ligand dynamics in the accurate determination of the binding pose, an aspect that is not addressed in typical docking and scoring protocols.
Hybrid Dynamics Simulation Engine for Metalloproteins
Creators: name: Ding, Feng
name: Alexandrova, Anastassia N.
name: Sparta, Manuel
name: Shirvanyants, David
name: Dokholyan, Nikolay V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Quality computational description of metalloproteins is a great challenge due to the vast span of time- and lengthscales characteristic of their existence. We present an efficient new method that allows for robust characterization of metalloproteins. It combines quantum mechanical (QM) description of the metal-containing active site, and extensive dynamics of the protein captured by discrete molecular dynamics (DMD) (QM/DMD). DMD samples the entire protein, including the backbone, and most of the active site, except for the immediate coordination region of the metal. QM operates on the part of the protein of electronic and chemical significance, which may include tens to hundreds of atoms. The breathing quantum-classical boundary provides a continuous mutual feedback between the two machineries. We test QM/DMD using the Fe-containing electron transporter protein, rubredoxin, and its three mutants as a model. QM/DMD can provide a reliable balanced description of metalloproteins’ structure, dynamics, and electronic structure in a reasonable amount of time. As an illustration of QM/DMD capabilities, we then predict the structure of the Ca2+ form of the enzyme catechol O-methyl transferase, which, unlike the native Mg2+ form, is catalytically inactive. The Mg2+ site is ochtahedral, but the Ca2+ is 7-coordinate and features the misalignment of the reacting parts of the system. The change is facilitated by the backbone adjustment. QM/DMD is ideal and fast for providing this level of structural insight.
ChatGPT 101: Introduction to Generative AI
Creators: Kung, Janice Y
Publisher: name: University of Alberta Library
Year: 2023

The slides accompany a ChatGPT workshop that is intended for university students to learn more about generative AI and in the context of ChatGPT. This work is licensed under a Creative Commons license so that others may share and adapt the content for other purposes as long as appropriate credit is provided to the author of the work. To access the Google slides, click here: https://docs.google.com/presentation/d/1JJBSCEv95McD5Zt8lWklzGJIiKiAXqWBvYFyNjPBO-U/edit?usp=sharing

Learning Objectives:

Explain how ChatGPT works

Describe at least 5 different ways to write good prompts

Summarize some ethical concerns when using generative AI
The instability of farm income. Empirical evidences on aggregation bias and heterogeneity among farm groups
Creators: name: Severini, Simone
name: Tantari, Antonella
name: Di Tommaso, Giuliano
Publisher: name: Bio-based and Applied Economics
Year: 2016

description: This paper analyses the instability of farm income experienced by a constant sample of Italian farms over the period 2003-2012. It assesses the extent of the aggregation bias due to the use of aggregated vs. single farm data and estimates the level of farm income variability in several groups of farms for the whole period and for two sub-periods. Differences between groups and periods are assessed by means of non-parametric tests. Results suggest that analyses based on aggregated farm data are likely going to strongly underestimate the extent of income variability faced by farmers. Income variability levels differ among farm groups and have significantly increased over the considered time. This has policy implications regarding the risk management tools recently introduced within the Rural Development Policies and how these should be targeted on the farms that more need them.
description: Bio-based and Applied Economics, Vol 5 No 1 (2016)
Modeling and control of a hybrid electric vehicle to optimize system performance for fuel efficiency
Creators: name: T, Jarin
Publisher: name: figshare
Year: 2023
Subjects: Electrical engineering not elsewhere classified

description: The improvement of fuel economy and the environmental consequences are important societal goals. In this paper, the modeling and regulation of a hybrid electric vehicle is explored to optimize system performance for fuel-efficiency. The internal combustion engine is a part of the mechanical design, while controller design and electrical subsystem are a part of the electrical design. To improve fuel efficiency in a hybrid electric vehicle is to combine an electric motor, a battery, and an internal combustion engine. The electric motor assists the engine when accelerating, driving longer highways, or climbing hills. This enables the use of a smaller, more efficient engine. It also makes use of the concept of regenerative braking to maximize energy efficiency. Thus, the NEDC and UDDS driving cycles may not accurately represent the actual situation and are progressively being replaced to HWFET driving cycle. In this paper, the Adaptive Neuro-Fuzzy Inference System (ANFIS) controller was used to analyze the engine, motor performance, and the HWFET was used in the vehicle driving test using Matlab/Simulink. The controller will be based on both the desired driving speed and the battery charge level. The implementation of optimal control based on an adaptive neuro-fuzzy inference system that decreases internal combustion engine fuel consumption is the paper's main contribution.
Comparative study of rare earth hexaborides using high resolution angle-resolved photoemission
Creators: name: Ramankutty, Shyama V.
name: de Jong, Nick
name: Huang, Ying-Kai
name: Zwartsenberg, Berend
name: Massee, Freek
name: Bay, Tran V.
name: Golden, Mark S.
name: Frantzeskakis, Emmanouil
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Strong electron correlations in rare earth hexaborides can give rise to a variety of interesting phenomena like ferromagnetism, Kondo hybridization, mixed valence, superconductivity and possibly topological characteristics. The theoretical prediction of topological properties in SmB$_{6}$ and YbB$_{6}$, has rekindled the scientific interest in the rare earth hexaborides, and high-resolution ARPES has been playing a major role in the debate. The electronic band structure of the hexaborides contains the key to understand the origin of the different phenomena observed, and much can be learned by comparing the experimental data from different rare earth hexaborides. We have performed high-resolution ARPES on the (001) surfaces of YbB$_{6}$, CeB$_{6}$ and SmB$_{6}$. On the most basic level, the data show that the differences in the valence of the rare earth element are reflected in the experimental electronic band structure primarily as a rigid shift of the energy position of the metal 5$\textit{d}$ states with respect to the Fermi level. Although the overall shape of the $\textit{d}$-derived Fermi surface contours remains the same, we report differences in the dimensionality of these states between the compounds studied. Moreover, the spectroscopic fingerprint of the 4$\textit{f}$ states also reveals considerable differences that are related to their coherence and the strength of the $\textit{d}$-$\textit{f}$ hybridization. For the SmB$_6$ case, we use ARPES in combination with STM imaging and electron diffraction to reveal time dependent changes in the structural symmetry of the highly debated SmB$_{6}$(001) surface. All in all, our study highlights the suitability of electron spectroscopies like high-resolution ARPES to provide links between electronic structure and function in complex and correlated materials such as the rare earth hexaborides.
description: 10 pages, 5 figures
Theoretical Search for Gravitational Bound States of Tachyons
Creators: name: Schwartz, Charles
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: The mission here is to see if we can find bound states for tachyons in some gravitational environment. That could provide an explanation for the phenomena called Dark Matter. Starting with the standard Schwarzschild metric in General Relativity, which is for a static and spherically symmetric source, it appears unlikely that such localized orbits exist. In this work the usual assumption of isotropic pressure is replaced by a model that has different pressures in the radial and angular directions. This should be relevant to the study of neutrinos, especially if they are tachyons, in cosmological models. We do find an arrangement that allows bound orbits for tachyons in a galaxy. This is a qualitative breakthrough. Then we go on to estimate the numbers involved and find that we do have a fair quantitative fit to the experimental data on the Galaxy Rotation Curve. Additionally we are led to look in the neighborhood of a Black Hole and there we find novel orbits for tachyons.
description: 21 pages
Three essays on applying analytics and exogenous data to government and nonprofit accounting
Creators: name: Wang, Xinxin
Publisher: name: No Publisher Supplied
Year: 2023

description: These three essays are applications of analytics and exogenous data to the public sector. The first chapter is based on data from the Annual Comprehensive Financial Report (ACFR) of different municipalities within New York State. Using textual analysis methods, it analyzes the usability of municipalities’ Management's Discussion and Analysis (MD&A). Considering the importance of MD&A and the potential predictive information it can reveal, this study measures the usability of the ACFRs from the perspectives of timeliness, readability, and usefulness. The results show that the usability of ACFR’s MD&A is very low due to several factors: the lag in report issuance, the difficulty for the public to understand the information disclosed, and the high level of similarity in these disclosures from year to year. The suggestions for municipalities to increase the usability of their reports by including a more detailed discussion and in-depth analysis in the MD&A. Most importantly, municipalities should provide the public with machine-readable financial information.The second chapter predicts the discontinuity of non-profit organizations (NPOs) using machine learning algorithms. NPOs are a key social sector that contributes greatly to the economy, social welfare, and human services. In the United States, NPOs are usually defined as organizations that are granted tax-exempt status. The negative impacts of the discontinuity of NPOs is reflected at the organizational, industrial, and economic levels. The second chapter aims to identify the financial, organizational, and managerial indicators that predict the discontinuity of NPOs. Results from applying different machine learning algorithms show that Gradient Boosting algorithms perform the best. The discontinuity of NPOs is relevant to whether an organization obtains independent auditing of financial statements, fundraising activities, breakeven indicators, program expense ratios, government grant amounts, and reportable investment. This study provides insights for researchers, regulators, management, and donors to NPOs with signals indicating possible organizational failures. The third chapter proposes “Government – Social Monitoring Analytical Reporting Technologies” (G-SMART) framework, which utilizes exogenous data to support social services in the setting of smart cities. With the inevitable trend of urbanization and the need to provide high quality city life, smart cities will be more prevalent in the future. Chapter 3 uses data from the City of Newark to illustrate the framework's operation. The goal is to improve the Supplemental Nutrition Assistance Program (SNAP) application, review, disbursement, and audit processes. Using food insecurity as an example, this research demonstrates the flexibility and the timely and accurate response of the G-SMART cycle. It also provides evidence that exogenous data could be used to improve smart city services.
(101321) William Leigh
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Geographical indications, food safety, and sustainability: conflicts and synergies
Creators: name: Wirth, David
Publisher: name: Bio-based and Applied Economics
Year: 2016

description: This paper examines the legal and policy relationships amongst international standards for GIs, food safety requirements, and voluntary claims related to a food’s attributes. The paper addresses those relationships within the context of international trade agreements protecting GIs, such as the 1994 TRIPS Agreement, the EU-Canada Comprehensive Economic and Trade Agreement (CETA), and the chapter on intellectual property and geographical indications in the Transatlantic Trade and Investment Partnership (TTIP) currently under negotiation. Trade agreements also discipline food safety measures and non-GI indications of quality or safety such as “organic” and “GMO-free.” Accordingly, the paper also considers the extent to which international trade agreements such as the WTO Agreements on the Application of Sanitary and Phytosanitary Standards (SPS Agreement) and Technical Barriers to Trade (TBT) might interact with the analysis.
description: Bio-based and Applied Economics, Vol 5 No 2 (2016)
(101320) Sarah Jane Leigh
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Phosphatidylserine Inhibits and Calcium Promotes Model Membrane Fusion
Creators: name: Lentz, Barry R.
name: Chakraborty, Hirak
name: Tarafdar, Pradip K.
name: Dennison, S. Moses
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: PEG-mediated fusion of SUVs composed of dioleoylphosphatidylcholine, dioleoylphosphatidylethanolamine, sphingomyelin, cholesterol, and dioleoylphosphatidylserine was examined to investigate the effects of PS on the fusion mechanism. Lipid mixing, content mixing, and content leakage measurements were carried out with vesicles containing from 0 to 8 mol % PS and similar amounts of phosphatidylglycerol. Fitting these time courses globally to a 3-state (aggregate, intermediate, pore) sequential model established rate constants for each step and probabilities of lipid mixing, content mixing, and leakage in each state. Charged lipids inhibited both the rates of intermediate and pore formation as well as the extents of lipid and contents mixing, although electrostatics were not solely responsible for inhibition. Ca2+ counteracted this inhibition and increased the extent of fusion in the presence of PS to well beyond that seen in the absence of charged lipids. The effects of both PS and Ca2+ could be interpreted in terms of a previous proposal for the nature of lipid fluctuations that account for transition states for the two steps of the fusion process examined. The results suggest a more significant role for Ca2+-lipid interactions than is acknowledged in current thinking about cell membrane fusion.
(101319) William George Leigh
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Επανακατοίκιση στου Ψυρρή: προτάσεις καθημερινής ζωής στο ιστορικό κέντρο της Αθήνας

title: Re-living in Psiri: everyday life suggestions in the historical Athens centre
Creators: name: Βουτσα Ιωαννα-Νεφελη
Publisher: name: Technical University of Crete
Year: 2020

description: Η διπλωματική εργασία πραγματεύεται την επανένταξη της κατοικίας στο ιστορικό κέντρο της Αθήνας, και συγκεκριμένα στην περιοχή του Ψυρρή. Η υψηλή συγκέντρωση των χρήσεων της αναψυχής-εστίασης, του τουρισμού, αλλά και η ερήμωση που ακολούθησε την απομάκρυνση της μεταποιητικής δραστηριότητας στην περιοχή, αναδεικνύουν την ανάγκη να επανενταχθεί η κατοικία ως οργανικό στοιχείο στη βάση του επιθυμητού πολυλειτουργικού χαρακτήρα του κέντρου της πόλης. Η κατοικία καλείται να λειτουργήσει ως αντίβαρο στην υποβάθμιση του δημόσιου χώρου, στην όχληση, στην κυκλοφοριακή συμφόρηση, στην έλλειψη πρασίνου και σε άλλα παρεμφερή προβλήματα της περιοχής.
Η πρόταση αφορά στην επαναδιατύπωση τεσσάρων οικοδομικών τετραγώνων, κατά βάση σε αμήχανα αστικά κενά που σήμερα λειτουργούν επιβαρυντικά για την περιοχή ως πάρκινγκ. Τις κατοικίες πλαισιώνουν μικρής κλίμακας επαγγελματικοί χώροι στο επίπεδο του ισογείου, υπαίθριες δημόσιες χρήσεις (χώρος προβολών, παιδική χαρά ), συλλογικές εξυπηρετήσεις της κατοικίας στα επίπεδα του ισογείου και των δωμάτων, καθώς και δημόσιες χρήσεις κυρίως πολιτιστικού χαρακτήρα (μικρή βιβλιοθήκη, εκθεσιακός χώρος, χώροι πολιτιστικών ομάδων, χώρος απασχόλησης παιδιών και ηλικιωμένων, κοινωνική κουζίνα). Έμφαση δίνεται στη συμμετοχική αξιοποίηση του ακάλυπτου χώρου των οικοδομικών τετραγώνων ώστε να αποτελέσει για τους κατοίκους τόπο συνάντησης, συναναστροφής, έκφρασης, παιχνιδιού αλλά και για την πόλη ευρύτερα μια εναλλακτική αφήγηση- περιπλάνηση καθώς και βελτίωση του μικροκλίματος μέσω της φύτευσης.
(101318) Nathaniel Poole Leigh
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Super-Resolution Imaging of C-Type Lectin and Influenza Hemagglutinin Nanodomains on Plasma Membranes Using Blink Microscopy
Creators: name: Neumann, Aaron K.
name: Thompson, Nancy L.
name: Forthmann, Carsten
name: Liu, Ping
name: Steinhauer, Christian
name: Itano, Michelle S.
name: Tinnefeld, Philip
name: Schmied, Jürgen J.
name: Jacobson, Ken
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Dendritic cells express DC-SIGN, a C-type lectin (CTL) that binds a variety of pathogens and facilitates their uptake for subsequent antigen presentation. DC-SIGN forms remarkably stable microdomains on the plasma membrane. However, inner leaflet lipid markers are able to diffuse through these microdomains suggesting that, rather than being densely packed with DC-SIGN proteins, an elemental substructure exists. Therefore, a super-resolution imaging technique, Blink Microscopy (Blink), was applied to further investigate the lateral distribution of DC-SIGN. Blink indicates that DC-SIGN, another CTL (CD206), and influenza hemagglutinin (HA) are all localized in small (∼80 nm in diameter) nanodomains. DC-SIGN and CD206 nanodomains are randomly distributed on the plasma membrane, whereas HA nanodomains cluster on length scales up to several microns. We estimate, as a lower limit, that DC-SIGN and HA nanodomains contain on average two tetramers or two trimers, respectively, whereas CD206 is often nonoligomerized. Two-color Blink determined that different CTLs rarely occupy the same nanodomain, although they appear colocalized using wide-field microscopy. What to our knowledge is a novel domain structure emerges in which elemental nanodomains, potentially capable of binding viruses, are organized in a random fashion; evidently, these nanodomains can be clustered into larger microdomains that act as receptor platforms for larger pathogens like yeasts.
Barjols, à l'abattoir, poursuite de l'écorchage du bœuf
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
Projection-free approximate balanced truncation of large unstable systems
Creators: name: Flinois, Thibault L. B.
name: Morgans, Aimee S.
name: Schmid, Peter J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: In this article, we show that the projection-free, snapshot-based, balanced truncation method can be applied directly to unstable systems. We prove that even for unstable systems, the unmodified balanced proper orthogonal decomposition algorithm theoretically yields a converged transformation that balances the Gramians (including the unstable subspace). We then apply the method to a spatially developing unstable system and show that it results in reduced-order models of similar quality to the ones obtained with existing methods. Due to the unbounded growth of unstable modes, a practical restriction on the final impulse response simulation time appears, which can be adjusted depending on the desired order of the reduced-order model. Recommendations are given to further reduce the cost of the method if the system is large and to improve the performance of the method if it does not yield acceptable results in its unmodified form. Finally, the method is applied to the linearized flow around a cylinder at Re = 100 to show that it actually is able to accurately reproduce impulse responses for more realistic unstable large-scale systems in practice. The well-established approximate balanced truncation numerical framework can therefore be safely applied to unstable systems without any modifications. Additionally, balanced reduced-order models can readily be obtained even for large systems, where the computational cost of existing methods is prohibitive.
title: Servitization in the Power-Two-Wheeler industry - Comparability and transferability of out-of-industry service solutions
Creators: name: Kerkápoly, Marton
Publisher: name: TU Wien
Year: 2020
Subjects: subject: non-power-two-wheeler
subject: motorcycle industry
subject: revenue
subject: service solution
subject: service-product integration and development
subject: comparability and transferability

description: The thesis explores the comparability and transferability of service solutions of non-power-two-wheeler industries into the motorcycle industry. The power-two-wheeler industry is facing the challenge of integrating and offering value adding services for customers that trigger increases in revenue. Most of the related industries, like automotive, face the same challenge but have different levels of capacity and resources available for the development of new offers, while the power-two-wheeler industry is limited in these factors. This further increases the need for ways of new ways of determining meaningful and high potential avenues for service-product integration and development. Additional pressures are created by a slowing in market growth, requiring the establishment of new revenue streams. The thesis establishes and practically exercises an additional way for determining the most comparable set of industries to the power-two-wheeler industry and the process of develop transferable solutions that match the basic characteristics of the industry. The process is a cascade of steps narrowing down matching products and industries and finally contrasting these with research generated general criteria for successful implementation and type of services.
Biophysical Model of Ion Transport across Human Respiratory Epithelia Allows Quantification of Ion Permeabilities
Creators: name: Boucher, Richard C.
name: Garcia, Guilherme J.M.
name: Elston, Timothy C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Lung health and normal mucus clearance depend on adequate hydration of airway surfaces. Because transepithelial osmotic gradients drive water flows, sufficient hydration of the airway surface liquid depends on a balance between ion secretion and absorption by respiratory epithelia. In vitro experiments using cultures of primary human nasal epithelia and human bronchial epithelia have established many of the biophysical processes involved in airway surface liquid homeostasis. Most experimental studies, however, have focused on the apical membrane, despite the fact that ion transport across respiratory epithelia involves both cellular and paracellular pathways. In fact, the ion permeabilities of the basolateral membrane and paracellular pathway remain largely unknown. Here we use a biophysical model for water and ion transport to quantify ion permeabilities of all pathways (apical, basolateral, paracellular) in human nasal epithelia cultures using experimental (Ussing Chamber and microelectrode) data reported in the literature. We derive analytical formulas for the steady-state short-circuit current and membrane potential, which are for polarized epithelia the equivalent of the Goldman-Hodgkin-Katz equation for single isolated cells. These relations allow parameter estimation to be performed efficiently. By providing a method to quantify all the ion permeabilities of respiratory epithelia, the model may aid us in understanding the physiology that regulates normal airway surface hydration.
(101317) John Barnard Leigh
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Phylogenetic analysis of CPSI, II and III from Adaptation of the carbamoyl-phosphate synthetase enzyme in an extremophile fish
Creators: name: White, Lewis J.
name: Sutton, Gemma
name: Asilatu Shechonge
name: Day, Julia J.
name: Kanchon K. Dasmahapatra
name: Pownall, Mary E.
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: Biochemistry
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Developmental Biology

description: Phylogeny confirming the Alcolapia sequences discussed are indeed CPS III
Confinement-Dependent Friction in Peptide Bundles
Creators: name: Erbaş, Aykut
name: Netz, Roland R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Friction within globular proteins or between adhering macromolecules crucially determines the kinetics of protein folding, the formation, and the relaxation of self-assembled molecular systems. One fundamental question is how these friction effects depend on the local environment and in particular on the presence of water. In this model study, we use fully atomistic MD simulations with explicit water to obtain friction forces as a single polyglycine peptide chain is pulled out of a bundle of k adhering parallel polyglycine peptide chains. The whole system is periodically replicated along the peptide axes, so a stationary state at prescribed mean sliding velocity V is achieved. The aggregation number is varied between k = 2 (two peptide chains adhering to each other with plenty of water present at the adhesion sites) and k = 7 (one peptide chain pulled out from a close-packed cylindrical array of six neighboring peptide chains with no water inside the bundle). The friction coefficient per hydrogen bond, extrapolated to the viscous limit of vanishing pulling velocity V → 0, exhibits an increase by five orders of magnitude when going from k = 2 to k = 7. This dramatic confinement-induced friction enhancement we argue to be due to a combination of water depletion and increased hydrogen-bond cooperativity.
Barjols, à l'abattoir, poursuite du vidage du boeuf écorché
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
(101316) Alice Leigh
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
ReCon: Revealing and Controlling PII Leaks in Mobile Network Traffic
Creators: name: Ren, Jingjing
name: Rao, Ashwin
name: Lindorfer, Martina
name: Legout, Arnaud
name: Choffnes, David
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cryptography and Security (cs.CR)
subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: It is well known that apps running on mobile devices extensively track and leak users' personally identifiable information (PII); however, these users have little visibility into PII leaked through the network traffic generated by their devices, and have poor control over how, when and where that traffic is sent and handled by third parties. In this paper, we present the design, implementation, and evaluation of ReCon: a cross-platform system that reveals PII leaks and gives users control over them without requiring any special privileges or custom OSes. ReCon leverages machine learning to reveal potential PII leaks by inspecting network traffic, and provides a visualization tool to empower users with the ability to control these leaks via blocking or substitution of PII. We evaluate ReCon's effectiveness with measurements from controlled experiments using leaks from the 100 most popular iOS, Android, and Windows Phone apps, and via an IRB-approved user study with 92 participants. We show that ReCon is accurate, efficient, and identifies a wider range of PII than previous approaches.
description: Please use MobiSys version when referencing this work: http://dl.acm.org/citation.cfm?id=2906392. 18 pages, recon.meddle.mobi
Towards an economics of the bioeconomy: four years later
Creators: name: Viaggi, Davide
Publisher: name: Bio-based and Applied Economics
Year: 2017

description: This paper provides a summary of the evolution of the bioeconomy and compares it with trends in related economics literature. The objective is to discuss how the bio-based economics literature from recent years matches real world concerns and to emphasise emerging needs, in order to derive implications for economic research. Though ‘bioeconomy economics and policy’ is still far from being a well-established discipline, the current literature seems to recognise scope for its development together with (and contributing to) the development of the bioeconomy as a whole. Several emerging research areas are identified, ranging from the quantification of bioeconomy components and biomass flows, to the political economy of the bioeconomy. However, the economics of the bioeconomy needs most likely to develop not as an independent research area, but rather in close connection with the more ‘traditional’, but highly lively and innovating, areas of agriculture and food economics.
description: Bio-based and Applied Economics, Vol 5 No 2 (2016)
Fusion Peptides Promote Formation of Bilayer Cubic Phases in Lipid Dispersions. An X-Ray Diffraction Study
Creators: name: MacDonald, Robert C.
name: Tenchov, Boris G.
name: Lentz, Barry R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Small angle x-ray diffraction revealed a strong influence of the N-terminal influenza hemagglutinin fusion peptide on the formation of nonlamellar lipid phases. Comparative measurements were made on a series of three peptides, a 20-residue wild-type X-31 influenza virus fusion peptide, GLFGAIAGFIENGWEGMIDG, and its two point-mutant, fusion-incompetent peptides G1E and G13L, in mixtures with hydrated phospholipids, either dipalmitoleoylphosphatidylethanolamine (DPoPE), or monomethylated dioleoyl phosphatidylethanolamine (DOPE-Me), at lipid/peptide molar ratios of 200:1 and 50:1. All three peptides suppressed the HII phase and shifted the Lα–HII transition to higher temperatures, simultaneously promoting formation of inverted bicontinuous cubic phases, QII, which becomes inserted between the Lα and HII phases on the temperature scale. Peptide-induced QII had strongly reduced lattice constants in comparison to the QII phases that form in pure lipids. QII formation was favored at the expense of both Lα and HII phases. The wild-type fusion peptide, WT-20, was distinguished from G1E and G13L by the markedly greater magnitude of its effect. WT-20 disordered the Lα phase and completely abolished the HII phase in DOPE-Me/WT-20 50:1 dispersions, converted the QII phase type from Im3m to Pn3m and reduced the unit cell size from ∼38 nm for the Im3m phase of DOPE-Me dispersions to ∼15 nm for the Pn3m phase in DOPE-Me/WT-20 peptide mixtures. The strong reduction of the cubic phase lattice parameter suggests that the fusion-promoting WT-20 peptide may function by favoring bilayer states of more negative Gaussian curvature and promoting fusion along pathways involving Pn3m phase-like fusion pore intermediates rather than pathways involving HII phase-like intermediates.
Table of primers for sequencing CPS III from Adaptation of the carbamoyl-phosphate synthetase enzyme in an extremophile fish
Creators: name: White, Lewis J.
name: Sutton, Gemma
name: Asilatu Shechonge
name: Day, Julia J.
name: Kanchon K. Dasmahapatra
name: Pownall, Mary E.
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: Biochemistry
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Developmental Biology

description: Table of primers for sequencing CPS III from Alcolapia species
The material politics of plastic: living differently for the future
Creators: name: REYNOLDS, DAVID ORO
Publisher: name: Monash University
Year: 2022
Subjects: Environmental sociology
Waste management, reduction, reuse and recycling
Family care
Sociology and social studies of science and technology
Human geography not elsewhere classified
Environmental politics
Gender and politics
Political economy and social change
Family and household studies

description: Plastic materials pose environmental and other problems around the world today. This thesis explores the experiences, activities and perspectives of people who avoid plastic materials in Australia. This group of people shared experiences of avoiding plastics at the household level, revealing a distinctive form of politics which I describe as ‘the material politics of plastic’. This politics involves hard work, emotions, caring, and changes in the way people live. Pioneering innovative ways of living with less plastics is led by women undertaking care work at home. Avoiding plastics is a tangible way for people to act against global environmental crises.
Hedgehog spin texture and competing orders associated with strains on the surface of a topological crystalline insulator
Creators: name: Huang, Cheng-Yi
name: Lin, Hsin
name: Wang, Yung Jui
name: Bansil, Arun
name: Tsai, Wei-Feng
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We have investigated spin reorientation phenomena and interaction driven effects under the presence of applied strains on the (001) surface of Pb$_{1-x}$Sn$_x$(Te, Se) topological crystalline insulators, which host multiple Dirac cones. Our analysis is based on a four-band $k\cdot p$ model, which captures the spin and orbital textures of the surface states at low energies around the $\bar{X}$ and $\bar{Y}$ points, including the Lifshitz transition. Even without breaking the time-reversal symmetry, we find that certain strains which break the mirror symmetry can induce hedgehog-like spin texture associated with gap formation at the Dirac points. The Chern number of the gapped surface ground state is shown to be tunable through the interplay of strains and a perpendicular Zeeman field. We also consider effects of strain in the presence of interactions in driving competing orders, and obtain the associated phase diagram at the mean-field level. Potential applications of our results for low power consuming electronics are discussed.
description: 11 pages, 9 figures, and two tables
(101315) Jane Barnard
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.