cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Solution Geochemistry of the Water of Limestone Terrains
Creators: name: Thrailkill, John
name: Beiter, David B.
name: Osolnik, Michael T.
name: Postley, Roger H.
name: Mitchell, William T.
name: Plummer, Leonard N.
name: Riddell, James R.
name: Worley, Richard C.
name: Zwicker, Robert D.
Publisher: name: Kentucky Water Resources Research Institute, University of Kentucky
Year: 1969

description: Abstract:
Limestone groundwater flows mainly in openings it has solutionally enlarged, thus an understanding of the water's state of saturation relative to calcite (the principal mineral component of limestone) is fundamental to an understanding of the nature and evolution of the limestone aquifer. This study investigated the Mammoth Cave-Sinkhole Plain (MCSP) and Cave Hollow (CH) aquifers in Kentucky, both in Missippian limestones.
Both aquifers were always undersaturated with calcite. Except for completely ventilated vadose flows (usually) and some vadose seepage (occasionally), all recharges sampled (sinking streams, vadose flows, and vadose seepage) were also undersaturated. The lack of saturation in the MCSP aquifer was due to the introduction of carbon dioxide into the water in amounts difficult to explain by the carbon dioxide content of the above recharges. In both vadose flows and seepage, undersaturatlon tended to correlate directly with flow volume, and there was an inverse correlation between the amount of carbon dioxide and calcite saturation in most of the waters sampled. In vadose seepage this relationship was so strong as to suggest seasonal invariance of carbon dioxide content of the water prior to out gassing.
Results suggest solutional enlargement is greatest near recharge points in "ventilated" aquifers (CH) but the carbon dioxide introduction phenomenon (MCSP) allows solution over wide areas in "unventilated" aquifers.
Funding information: The work upon which this report is based was supported by funds provided by the United States Department of the Interior, Office of Water Resources Research, as authorized under the Water Resources Research Act of 1964.
Thermalization, Isotropization and Elliptic Flow from Nonequilibrium Initial Conditions with a Saturation Scale
Creators: name: Ruggieri, Marco
name: Scardina, Francesco
name: Plumari, Salvatore
name: Greco, Vincenzo
Publisher: name: arXiv
Year: 2013
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: In this article we report on our results about the computation of the elliptic flow of the quark-gluon-plasma produced in relativistic heavy ion collisions, simulating the expansion of the fireball by solving the relativistic Boltzmann equation for the parton distribution function tuned at a fixed shear viscosity to entropy density ratio $η/s$. Our main goal is to put emphasis on the role of a saturation scale in the initial gluon spectrum, which makes the initial distribution far from a thermalized one. We find that the presence of the saturation scale reduces the efficiency in building-up the elliptic flow, even if the thermalization process is quite fast $τ_{therm} \approx 0.8 \,\rm fm/c$ and the pressure isotropization even faster $τ_{isotr} \approx 0.3 \,\rm fm/c$. The impact of the non-equilibrium implied by the saturation scale manifests for non-central collisions and can modify the estimate of the viscosity respect to the assumption of full thermalization in $p_T$-space. We find that the estimate of $η/s$ is modified from $η/s \approx 2/4π$ to $η/s \approx 1/4π$ at RHIC and from $η/s \approx 3/4π$ to $η/s \approx 2/4π$ at LHC. We complete our investigation by a study of the thermalization and isotropization times of the fireball for different initial conditions and values of $η/s$ showing how the latter affects both isotropization and thermalization. Lastly, we have seen that the range of values explored by the phase-space distribution function $f$ is such that at $p_T<0.5\, \rm GeV$ the inner part of the fireball stays with occupation number significantly larger than unity despite the fast longitudinal expansion, which might suggest the possibility of the formation of a transient Bose-Einstein Condensate.
description: Published version
Higher abelian gauge theory associated to gerbes on noncommutative deformed M5-branes and S-duality
Creators: name: Mathai, Varghese
name: Sati, Hisham
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Differential Geometry (math.DG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We enhance the action of higher abelian gauge theory associated to a gerbe on an M5-brane with an action of a torus ${\mathbb T}^n (n\ge 2)$, by a noncommutative ${\mathbb T}^n$-deformation of the M5-brane. The ingredients of the noncommutative action and equations of motion include the deformed Hodge duality, deformed wedge product, and the noncommutative integral over the noncommutative space obtained by strict deformation quantization. As an application we then introduce a variant model with an enhanced action in which we show that the corresponding partition function is a modular form, which is a purely noncommutative geometry phenomenon since the usual theory only has a $\mathbb Z_2$-symmetry. In particular, S-duality in this 6-dimensional higher abelian gauge theory model is shown to be, in this sense, on par with the usual 4-dimensional case.
description: 23 pages, details and references added
Homotopy-theoretically enriched categories of noncommutative motives
Creators: name: Morava, Jack
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Topology (math.AT)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11G, 19F, 57R, 81T

description: Waldhausen's $K$-theory of the sphere spectrum (closely related to the algebraic $K$-theory of the integers) is a naturally augmented $S^0$-algebra, and so has a Koszul dual. Classic work of Deligne and Goncharov implies an identification of the rationalization of this (covariant) dual with the Hopf algebra of functions on the motivic group for their category of mixed Tate motives over $\Z$. This paper argues that the rationalizations of categories of non-commutative motives defined recently by Blumberg, Gepner, and Tabuada consequently have natural enrichments, with morphism objects in the derived category of mixed Tate motives over $\Z$. We suggest that homotopic descent theory lifts this structure to define a category of motives defined not over $\Z$ but over the sphere ring-spectrum $S^0$.
description: An attempt at a more readable version. Some reshuffling, a few new references, small notational changes. Thanks to many for comments about foolish blunders and obscurities
Association between childhood trauma and brain anatomy in women with post-traumatic stress disorder, women with borderline personality disorder, and healthy women
Creators: name: Rosada, Catarina
name: Bauer, Martin
name: Golde, Sabrina
name: Metz, Sophie
name: Roepke, Stefan
name: Otte, Christian
name: Wolf, Oliver T.
name: Buss, Claudia
name: Wingenfeld, Katja
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background: Childhood trauma (CT) is associated with altered brain anatomy. These neuroanatomical changes might be more pronounced in individuals with a psychiatric disorder. Post-traumatic stress disorder (PTSD) and borderline personality disorder (BPD) are more prevalent in individuals with a history of CT. Objective: In this study, we examined limbic and total brain volumes in healthy women with and without a history of CT and in females with PTSD or BPD and a history of CT to see whether neuroanatomical changes are a function of psychopathology or CT. Method: In total, 128 women (N = 70 healthy controls without CT, N = 25 healthy controls with CT, N = 14 individuals with PTSD, and N = 19 individuals with BPD) were recruited. A T1-weighted anatomical MRI was acquired from all participants for Freesurfer-based assessment of total brain, hippocampus, and amygdala volumes. Severity of CT was assessed with a clinical interview and the Childhood Trauma Questionnaire. Group differences in hippocampal and amygdala volumes (adjusted for total brain volume) and total brain volume (adjusted for height) were characterized by analysis of covariance. Results: Volume of the total brain, hippocampus, and amygdala did not differ between the four groups (p > .05). CT severity correlated negatively with total brain volume across groups (r = −0.20; p = .029). Conclusions: CT was associated with reduced brain volume but PTSD or BPD was not. The association between CT and reduced brain volume as a global measure of brain integrity suggests a common origin for vulnerability to psychiatric disorders later in life. No group differences (healthy women with and without CT, women with BPD and CT, women with PTSD and CT) in hippocampal, amygdala, and total brain volume.Significant negative association between CT severity with total brain volume and depressive symptoms with hippocampal volumes. No group differences (healthy women with and without CT, women with BPD and CT, women with PTSD and CT) in hippocampal, amygdala, and total brain volume. Significant negative association between CT severity with total brain volume and depressive symptoms with hippocampal volumes.
Towards Teachable Autotelic Agents
Creators: name: Sigaud, Olivier
name: Akakzia, Ahmed
name: Caselles-Dupré, Hugo
name: Colas, Cédric
name: Oudeyer, Pierre-Yves
name: Chetouani, Mohamed
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Autonomous discovery and direct instruction are two distinct sources of learning in children but education sciences demonstrate that mixed approaches such as assisted discovery or guided play result in improved skill acquisition. In the field of Artificial Intelligence, these extremes respectively map to autonomous agents learning from their own signals and interactive learning agents fully taught by their teachers. In between should stand teachable autotelic agents (TAA): agents that learn from both internal and teaching signals to benefit from the higher efficiency of assisted discovery. Designing such agents will enable real-world non-expert users to orient the learning trajectories of agents towards their expectations. More fundamentally, this may also be a key step to build agents with human-level intelligence. This paper presents a roadmap towards the design of teachable autonomous agents. Building on developmental psychology and education sciences, we start by identifying key features enabling assisted discovery processes in child-tutor interactions. This leads to the production of a checklist of features that future TAA will need to demonstrate. The checklist allows us to precisely pinpoint the various limitations of current reinforcement learning agents and to identify the promising first steps towards TAA. It also shows the way forward by highlighting key research directions towards the design or autonomous agents that can be taught by ordinary people via natural pedagogy.
Additional file 12 of Initial response of ovarian tissue transcriptome to vitrification or microwave-assisted dehydration in the domestic cat model
Creators: name: Amelkina, Olga
name: Comizzoli, Pierre
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 12: Table S2. Mapped data statistics.
Ab Initio Description of p-Shell Hypernuclei
Creators: name: Wirth, Roland
name: Gazda, Daniel
name: Navrátil, Petr
name: Calci, Angelo
name: Langhammer, Joachim
name: Roth, Robert
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present the first ab initio calculations for p-shell single-Lambda hypernuclei. For the solution of the many-baryon problem, we develop two variants of the no-core shell model with explicit $Λ$ and $Σ^+$, $Σ^0$, $Σ^-$ hyperons including $Λ$-$Σ$ conversion, optionally supplemented by a similarity renormalization group transformation to accelerate model-space convergence. In addition to state-of-the-art chiral two- and three-nucleon interactions, we use leading-order chiral hyperon-nucleon interactions and a recent meson-exchange hyperon-nucleon interaction. We validate the approach for s-shell hypernuclei and apply it to p-shell hypernuclei, in particular to $^7_Λ$Li, $^9_Λ$Be and $^{13}_Λ$C. We show that the chiral hyperon-nucleon interactions provide ground-state and excitation energies that agree with experiment within the cutoff dependence. At the same time we demonstrate that hypernuclear spectroscopy provides tight constraints on the hyperon-nucleon interactions and we discuss the impact of induced hyperon-nucleon-nucleon interactions.
description: 6 pages, 4 figures
Die Wahl der Mittel – Jupyter-Notebooks als Forschungsinfrastruktur
Creators: name: Jung, Kerstin
name: Hein, Pascal
name: Blessing, André
name: Hess, Jan
name: Kushnarenko, Volodymyr
Publisher: name: Zenodo
Year: 2023
Subjects: Jupyter-Notebooks
ausführbarer Quellcode
Python
Teilen
Programmierung
Veröffentlichung
Visualisierung
Infrastruktur
Software
DHd2023

description: Eine Posterpräsentation auf der 9. Tagung des Verbands "Digital Humanities im deutschsprachigen Raum" - DHd 2023 Open Humanities Open Culture
Fooling Partial Dependence via Data Poisoning
Creators: name: Baniecki, Hubert
name: Kretowicz, Wojciech
name: Biecek, Przemyslaw
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Many methods have been developed to understand complex predictive models and high expectations are placed on post-hoc model explainability. It turns out that such explanations are not robust nor trustworthy, and they can be fooled. This paper presents techniques for attacking Partial Dependence (plots, profiles, PDP), which are among the most popular methods of explaining any predictive model trained on tabular data. We showcase that PD can be manipulated in an adversarial manner, which is alarming, especially in financial or medical applications where auditability became a must-have trait supporting black-box machine learning. The fooling is performed via poisoning the data to bend and shift explanations in the desired direction using genetic and gradient algorithms. We believe this to be the first work using a genetic algorithm for manipulating explanations, which is transferable as it generalizes both ways: in a model-agnostic and an explanation-agnostic manner.
description: Accepted at ECML PKDD 2022
ТИЖОРАТ БАНКЛАРИНИНГ ФОНД БОЗОРИДАГИ ФАОЛИЯТИНИНГ АМАЛДАГИ ҲОЛАТИ ТАҲЛИЛИ
Creators: name: Бўриев, Жамшид
Publisher: name: Zenodo
Year: 2024

description: Ушбу мақолада тижорат банкларининг фонд бозоридаги фаолиятининг амалдаги ҳолати таҳлил қилинади. Банкларнинг фонд бозорига интеграциялашуви ва улар томонидан бажарилаётган функциялар иқтисодиётда муҳим аҳамиятга эга бўлиб, бозорнинг ликвидлиги ва барқарорлигига таъсир кўрсатади. Мақолада банклар томонидан амалга оширилаётган инвестиция стратегиялари, фонд бозорида капитал жалб қилиш усуллари, шунингдек, улар дуч келадиган молиявий рисклар ва уларни бошқариш механизмлари батафсил ўрганилади. Шунингдек, банкларнинг фонд бозоридаги фаолиятининг самарадорлигини ошириш бўйича тавсиялар келтирилади.
Type II-activated murine macrophages produce IL-4
Creators: name: La Flamme, Anne
name: Kharkrang, M
name: Stone, S
name: Mirmoeini, S
name: Chuluundorj, D
name: Kyle, R
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Background: Type II activation of macrophages is known to support Th2 responses development; however, the role of Th2 cytokines (esp. IL-4) on type II activation is unknown. To assess whether the central Th2 cytokine IL-4 can alter type II activation of macrophages, we compared the ability of bone marrow-derived macrophages from wild type (WT) and IL-4Rα-deficient mice to be classically or type II-activated in vitro. Results: We found that although both WT and IL-4Rα-deficient macrophages could be classically activated by LPS or type II activated by immune complexes plus LPS, IL-4Rα-deficient macrophages consistently produced much higher levels of IL-12p40 and IL-10 than WT macrophages. Additionally, we discovered that type II macrophages from both strains were capable of producing IL-4; however, this IL-4 was not responsible for the reduced IL-12p40 and IL-10 levels produced by WT mice. Instead, we found that derivation culture conditions (GM-CSF plus IL-3 versus M-CSF) could explain the different responses of BALB/c and IL-4Rα-/- macrophages, and these cytokines shaped the ensuing macrophage such that GM-CSF plus IL-3 promoted more IL-12 and IL-4 while M-CSF led to higher IL-10 production. Finally, we found that enhanced IL-4 production is characteristic of the type II activation state as other type II-activating products showed similar results. Conclusions: Taken together, these results implicate type II activated macrophages as an important innate immune source of IL-4 that may play an important role in shaping adaptive immune responses. © 2012 La Flamme et al.
Additional file 11 of Initial response of ovarian tissue transcriptome to vitrification or microwave-assisted dehydration in the domestic cat model
Creators: name: Amelkina, Olga
name: Comizzoli, Pierre
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 11: Table S1. Trimmed data statistics.
Anomalous phase separation dynamics in a correlated electron system: machine-learning enabled large-scale kinetic Monte Carlo simulations
Creators: name: Zhang, Sheng
name: Zhang, Puhan
name: Chern, Gia-Wei
Publisher: name: arXiv
Year: 2021
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Machine Learning (cs.LG)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Phase separation plays a central role in the emergence of novel functionalities of correlated electron materials. The structure of the mixed-phase states depends strongly on the nonequilibrium phase-separation dynamics, which has so far yet to be systematically investigated, especially on the theoretical side. With the aid of modern machine learning methods, we demonstrate the first-ever large-scale kinetic Monte Carlo simulations of the phase separation process for the Falicov-Kimball model, which is one of the canonical strongly correlated electron systems. We uncover an unusual phase-separation scenario where domain coarsening occurs simultaneously at two different scales: the growth of checkerboard clusters at smaller length scales and the expansion of super-clusters, which are aggregates of the checkerboard clusters of the same sign, at a larger scale. We show that the emergence of super-clusters is due to a hidden dynamical breaking of the sublattice symmetry. Arrested growth of the checkerboard patterns and of the super-clusters is shown to result from a correlation-induced self-trapping mechanism. Glassy behaviors similar to the one reported in this work could be generic for other correlated electron systems.
description: 11 pages, 11 figures
PTSD and complex PTSD in adolescence: discriminating factors in a population-based cross-sectional study
Creators: name: Daniunaite, Ieva
name: Cloitre, Marylene
name: Karatzias, Thanos
name: Shevlin, Mark
name: Thoresen, Siri
name: Zelviene, Paulina
name: Kazlauskas, Evaldas
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background: Chronic and repeated trauma are well-established risk factors for complex posttraumatic stress disorder (CPTSD) in adult samples. Less is known about how trauma history and other factors contribute to the development of CPTSD in adolescence. Objective: The aim of this study was to assess the potential contribution of trauma history and social factors to CPTSD in adolescents. Method: In a cross-sectional community study of 1299 adolescents aged 12–16 years, PTSD (n = 97) and CPTSD (n = 108) was assessed with the Child and Adolescent version of the International Trauma Questionnaire (ITQ-CA). Trauma exposure, family functioning, school problems, and social support as potential discriminating factors between the PTSD and CPTSD groups were investigated. Results: Cumulative trauma exposure did not discriminate between PTSD and CPTSD in this sample. CPTSD was associated with family problems (such as financial difficulties and conflicts in the home), school problems (bullying and learning difficulties), and lack of social support. Conclusions: Our study indicates that factors other than cumulative trauma are important for the development of CPTSD in adolescence. Interventions targeting adolescent’s social environment both at home and at school may be beneficial. Social factors, such as family problems, school problems, and lack of social support are important predictors of complex posttraumatic stress in adolescence following traumatic events. Social factors, such as family problems, school problems, and lack of social support are important predictors of complex posttraumatic stress in adolescence following traumatic events.
Ecological Study of the Effects of Strip Mining on the Microbiology of Streams
Creators: name: Weaver, Ralph H.
name: Nash, Harry D.
Publisher: name: Kentucky Water Resources Research Institute, University of Kentucky
Year: 1968

description: Abstract:
The microflora of Cane Branch of Beaver Creek in McCreary County, Kentucky, which drains an area that was strip-mined between 1955 and 1959, was studied and compared with that of Helton Branch which drains a comparable area where there has been no mining. Differences include: the establishment of Ferrcbacillus ferrooxidans, for which procedures were developed for direct colony isolation from the stream; fewer saprophytic bacteria; more numerous and more diversified filamentous and unicellular fungi; and characteristic differences in algal flora. Representatives of 42 genera of filamentous fungi were identified. Of these, 21 were isolated only from Cane Branch. Representatives of five genera of unicellular fungi were found. One, Rhoclotorula, was found consistently in Cane Branch but never in Helton Branch. From 1966 to 1968, Bumilleria appears to have established itself as the dominate alga in Cane Branch at same distance downstream from the strip-mine drainage area, Seasonal differences in the microflora appear to be relatively insignificant, except for the algae.
Funding information: The work upon which this report is based was supported in part by the United States Department of the Interior, Office of Water Resources Research, as authorized under the Water Resources Research Act of 1964.
Effect of Prolonged Exposure, intensified Prolonged Exposure and STAIR+Prolonged Exposure in patients with PTSD related to childhood abuse: a randomized controlled trial
Creators: name: Oprel, Danielle A. C.
name: Hoeboer, Chris M.
name: Schoorl, Maartje
name: de Kleine, Rianne A.
name: Cloitre, Marylene
name: Wigard, Ingrid G.
name: van Minnen, Agnes
name: van der Does, Willem
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background: It is unclear whether the evidence-based treatments for PTSD are as effective in patients with CA-PTSD. Objective: We aimed to investigate the effectiveness of three variants of prolonged exposure therapy. Method: We recruited adults with CA-PTSD. Participants were randomly assigned to Prolonged Exposure (PE; 16 sessions in 16 weeks), intensified Prolonged Exposure (iPE; 12 sessions in 4 weeks followed by 2 booster sessions) or a phase-based treatment, in which 8 sessions of PE were preceded by 8 sessions of Skills Training in Affective and Interpersonal Regulation (STAIR+PE; 16 sessions in 16 weeks). Assessments took place in week 0 (baseline), week 4, week 8, week 16 (post-treatment) and at a 6-and 12-month follow-up. The primary outcome was clinician-rated PTSD symptom severity. Results: We randomly assigned 149 patients to PE (48), iPE (51) or STAIR+PE (50). All treatments resulted in large improvements in clinician assessed and self-reported PTSD symptoms from baseline to 1-year follow-up (Cohen’s d > 1.6), with no significant differences among treatments. iPE led to faster initial symptom reduction than PE for self-report PTSD symptoms (t135 = −2.85, p = .005, d = .49) but not clinician-assessed symptoms (t135 = −1.65, p = .10) and faster initial symptom reduction than STAIR+PE for self-reported (t135 = −4.11, p < .001, d = .71) and clinician-assessed symptoms (t135 = −2.77, p = .006, Cohen’s d = .48) STAIR+PE did not result in significantly more improvement from baseline to 1-year follow-up on the secondary outcome emotion regulation, interpersonal problems and self-esteem compared to PE and iPE. Dropout rates did not differ significantly between conditions. Conclusions: Variants of exposure therapy are tolerated well and lead to large improvements in patients with CA-PTSD. Intensifying treatment may lead to faster improvement but not to overall better outcomes. The trial is registered at the clinical trial registry, number NCT03194113, https://clinicaltrials.gov/ct2/show/NCT03194113 • Childhood abuse-related PTSD can be effectively treated with (variants of) exposure therapy. • STAIR+PE and intensified PE did not improve treatment outcomes compared to PE.• Intensified PE showed faster symptom improvement.
Role of the Ste20 Like Kinase in Muscle Development and Muscular Dystrophy
Creators: name: Pryce, Benjamin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2019
Subjects: SLK
Skeletal Muscle
Muscular Dystrophy

description: Duchenne Muscular Dystrophy (DMD) is a fatal X-linked disorder affecting 1 out of every 3500 male births. The underlying cause of DMD is mutations within the dystrophin gene resulting in loss of protein expression, which leads to myofiber instability and damage. The constant damage of skeletal muscle causes sustained immune infiltration, marked by increased levels of cytokines, such as TGF-beta. Interestingly, TGF-beta can decrease the myogenic potential of satellite cells, thus preventing muscle regeneration. Previously, our lab has shown that knockdown of the Ste20 Like Kinase, SLK, in normal mammary epithelial cells was sufficient to delay TGF-beta induced epithelial to mesenchymal transition. Therefore, we speculated that decreasing SLK levels would be sufficient to decrease the anti-myogenic effects of TGF-beta both in cultured myoblasts and in a mouse model of muscular dystrophy. In the first section of this study, we explored the effect of muscle specific deletion of SLK on muscle development and regeneration. Skeletal muscle specific deletion of SLK did not impair muscle development, but caused a myopathy in older mice. Additionally, muscle regeneration was delayed, but not inhibited by SLK deletion. These findings indicated that SLK has beneficial roles in skeletal muscle, but was not absolutely required for optimal muscle development and regeneration. In the second section, we investigated the potential for SLK knockdown to mitigate the anti-myogenic effects of TGF-beta in vitro. Decreasing levels of SLK restored myoblast differentiation in the presence of TGF-beta in a p38 dependent manner. In the final section, we determined that SLK levels are elevated in dystrophic muscle and that subsequent deletion of SLK in the mdx mouse enhances terminal differentiation of myoblasts without further exacerbating the pathology of the disease. Collectively, this work demonstrates that SLK inhibition can provide a protective effect against the anti-myogenic effects of TGF-beta via upregulation of p38 activity.
Contextuality degree of quadrics in multi-qubit symplectic polar spaces
Creators: name: de Boutray, Henri
name: Holweck, Frédéric
name: Giorgetti, Alain
name: Masson, Pierre-Alain
name: Saniga, Metod
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: Combinatorics (math.CO)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Quantum contextuality takes an important place amongst the concepts of quantum computing that bring an advantage over its classical counterpart. For a large class of contextuality proofs, aka. observable-based proofs of the Kochen-Specker Theorem, we formulate the contextuality property as the absence of solutions to a linear system and define for a contextual configuration its degree of contextuality. Then we explain why subgeometries of binary symplectic polar spaces are candidates for contextuality proofs. We report the results of a software that generates these subgeometries, decides their contextuality and computes their contextuality degree for some small symplectic polar spaces. We show that quadrics in the symplectic polar space $W_n$ are contextual for $n=3,4,5$. The proofs we consider involve more contexts and observables than the smallest known proofs. This intermediate size property of those proofs is interesting for experimental tests, but could also be interesting in quantum game theory.
description: 18 pages, 4 figures, 4 tables. Mistake in first line of Table 2 corrected
Local characterization of polyhedral spaces
Creators: name: Lebedeva, Nina
name: Petrunin, Anton
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: Metric Geometry (math.MG)
subject: FOS: Mathematics
subject: 53C99, 52B70, 05E45

description: We show that a compact length space is polyhedral if a small spherical neighborhood of any point is conic.
description: 7 pages 1 figure
Joint Image Reconstruction and Segmentation Using the Potts Model
Creators: name: Storath, Martin
name: Weinmann, Andreas
name: Frikel, Jürgen
name: Unser, Michael
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optimization and Control (math.OC)
subject: Numerical Analysis (math.NA)
subject: Medical Physics (physics.med-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We propose a new algorithmic approach to the non-smooth and non-convex Potts problem (also called piecewise-constant Mumford-Shah problem) for inverse imaging problems. We derive a suitable splitting into specific subproblems that can all be solved efficiently. Our method does not require a priori knowledge on the gray levels nor on the number of segments of the reconstruction. Further, it avoids anisotropic artifacts such as geometric staircasing. We demonstrate the suitability of our method for joint image reconstruction and segmentation. We focus on Radon data, where we in particular consider limited data situations. For instance, our method is able to recover all segments of the Shepp-Logan phantom from $7$ angular views only. We illustrate the practical applicability on a real PET dataset. As further applications, we consider spherical Radon data as well as blurred data.
Die digitale Schulbuch-Bibliothek GEI-Digital im neuen Gewand: Ein modernes Präsentationssystem öffnet digitalisierte Schulbücher für die Open Humanities
Creators: name: Klaes, Jan Sebastian
name: Krüger, Katharina
name: Leonhardt, Susann
name: Nieländer, Maret
name: Sommer, Kai
name: Towara, Nadine
Publisher: name: Zenodo
Year: 2023
Subjects: Bildungsmedien
Schulbücher
Digitale Bibliothek
Volltexte
Digitalisate
Sammlung
Webentwicklung
Daten
Bilder
Infrastruktur
DHd2023

description: Eine Posterpräsentation auf der 9. Tagung des Verbands "Digital Humanities im deutschsprachigen Raum" - DHd 2023 Open Humanities Open Culture
Constitutive Relation for Nonlinear Response and Universality of Efficiency at Maximum Power for Tight-Coupling Heat Engines
Creators: name: Sheng, Shiqi
name: Tu, Z. C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We present a unified perspective on nonequilibrium heat engines by generalizing nonlinear irreversible thermodynamics. For tight-coupling heat engines, a generic constitutive relation of nonlinear response accurate up to the quadratic order is derived from the symmetry argument and the stall condition. By applying this generic nonlinear constitutive relation to finite-time thermodynamics, we obtain the necessary and sufficient condition for the universality of efficiency at maximum power, which states that a tight-coupling heat engine takes the universal efficiency at maximum power up to the quadratic order if and only if either the engine symmetrically interacts with two heat reservoirs or the elementary thermal energy flowing through the engine matches the characteristic energy of the engine. As a result, we solve the following paradox: On the one hand, the universal quadratic term in the efficiency at maximum power for tight-coupling heat engines proved as a consequence of symmetry [M. Esposito, K. Lindenberg, and C. Van den Broeck, Phys. Rev. Lett. 102, 130602 (2009); S. Q. Sheng and Z. C. Tu, Phys. Rev. E 89, 012129 (2014)]; On the other hand, two typical heat engines including the Curzon-Ahlborn endoreversible heat engine [F. L. Curzon and B. Ahlborn, Am. J. Phys. 43, 22 (1975)] and the Feynman ratchet [Z. C. Tu, J. Phys. A 41, 312003 (2008)] recover the universal efficiency at maximum power regardless of any symmetry.
How do licensed psychotherapists in Germany feel about treating patients with posttraumatic stress symptoms? – an experimental study based on case vignettes
Creators: name: Gossmann, Katharina
name: Eilers, Rebekka
name: Rosner, Rita
name: Barke, Antonia
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background: Previous research indicates that not all children, adolescents and adults suffering from PTSD receive psychotherapy and if they do, trauma is not always considered during therapy. One reason for this undertreatment might be a limited readiness of licenced psychotherapists (LPTs) to treat patients who have experienced a trauma and thus suffer from PTSD symptoms. Objective: The aim of this study is to explore the association between the readiness of LPTs to treat patients with PTSD symptoms and different patients’ and therapists’ characteristics. Method: We used case vignettes to assess the readiness of LPTs in Germany in a nationwide online survey (N = 768). The vignettes described patients with PTSD and were adapted to the age group mainly treated by the therapists (children/adolescents vs. adults). The patients’ characteristics in the otherwise identical vignettes were randomized for patient gender (female vs. male) and symptom cluster (internalizing vs. externalizing). Rating scales were used to assess readiness. Additionally, therapists’ characteristics (age, trauma-specific training, perceived fears/doubts, and objective barriers to treating the vignette patient) were assessed. Results: The patients’ characteristics did not influence the treatment readiness of the LPTs. Regarding therapists’ characteristics, LPTs working mainly with children and adolescents, and those who had completed trauma-specific training reported a higher readiness to treat the vignette patient. Conclusions: Regarding the treatment of patients suffering from PTSD symptoms of different ages, our study indicated that the assessed therapists’ characteristics were more relevant for the treatment readiness of LPTs than the patients’ characteristics of age or symptom type. In this nationwide study based on randomly presented case vignettes, therapists’ characteristics like trauma-specific training or fears/doubt were more relevant for the readiness of licenced psychotherapists to treat patients with PTSD symptoms than patients’ characteristics. In this nationwide study based on randomly presented case vignettes, therapists’ characteristics like trauma-specific training or fears/doubt were more relevant for the readiness of licenced psychotherapists to treat patients with PTSD symptoms than patients’ characteristics.
БАНКЛАРИНИНГ ФОНД БОЗОРИДАГИ ФАОЛЛИГИНИ ОШИРИШ ЙЎЛЛАРИ
Creators: name: Бўриев, Жамшид
Publisher: name: Zenodo
Year: 2024

description: Мақолада банклар ва фонд бозори ўртасидаги ўзаро боғлиқлик, банкларнинг инвестор сифатида фонд бозори иштирокчиси бўлиши, шунингдек, фонд бозорида капитал жалб қилиш ва рискларни бошқариш усуллари кўриб чиқилади. Банклар фаолиятининг фонд бозоридаги ўзига хос хусусиятлари ҳамда бу жараёндаги назарий ёндашувлар батафсил ўрганилади.
Anyonic statistics and large horizon diffeomorphisms for Loop Quantum Gravity Black Holes
Creators: name: Pithis, Andreas G. A.
name: Euler, Hans-Christian Ruiz
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We investigate the role played by large diffeomorphisms of quantum Isolated Horizons for the statistics of LQG Black Holes by means of their relation to the braid group. To this aim the symmetries of Chern-Simons theory are recapitulated with particular regard to the aforementioned type of diffeomorphisms. For the punctured spherical horizon, these are elements of the mapping class group of $S^2$, which is almost isomorphic to a corresponding braid group on this particular manifold. The mutual exchange of quantum entities in two dimensions is achieved by the braid group, rendering the statistics anyonic. With this we argue that the quantum Isolated Horizon model of LQG based on $SU(2)_k$-Chern-Simons theory explicitly exhibits non-abelian anyonic statistics. In this way a connection to the theory behind the fractional quantum Hall effect and that of topological quantum computation is established, where non-abelian anyons play a significant role.
description: 20 pages, 8 figures, closest to published version
Mental health responses to COVID-19 around the world
Creators: name: Olff, Miranda
name: Primasari, Indira
name: Qing, Yulan
name: Coimbra, Bruno M.
name: Hovnanyan, Ani
name: Grace, Emma
name: Williamson, Rachel E.
name: Hoeboer, Chris M.
name: Consortium, the GPS-CCC
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background: The mental health impact of the COVID-19 crisis may differ from previously studied stressful events in terms of psychological reactions, specific risk factors, and symptom severity across geographic regions worldwide.Objective: To assess the impact of COVID-19 on a wide range of mental health symptoms, to identify relevant risk factors, to identify the effect of COVID-19 country impact on mental health, and to evaluate regional differences in psychological responses to COVID-19 compared to other stressful events.Method: 7034 respondents (74% female) participated in the worldwide Global Psychotrauma Screen – Cross-Cultural responses to COVID-19 study (GPS-CCC), reporting on mental health symptoms related to COVID-19 (n = 1838) or other stressful events (n = 5196) from April to November 2020.Results: Events related to COVID-19 were associated with more mental health symptoms compared to other stressful events, especially symptoms of PTSD, anxiety, depression, insomnia, and dissociation. Lack of social support, psychiatric history, childhood trauma, additional stressful events in the past month, and low resilience predicted more mental health problems for COVID-19 and other stressful events. Higher COVID-19 country impact was associated with increased mental health impact of both COVID-19 and other stressful events. Analysis of differences across geographic regions revealed that in Latin America more mental health symptoms were reported for COVID-19 related events versus other stressful events, while the opposite pattern was seen in North America.Conclusions: The mental health impact of COVID-19-related stressors covers a wide range of symptoms and is more severe than that of other stressful events. This difference was especially apparent in Latin America. The findings underscore the need for global screening for a wide range of mental health problems as part of a public health approach, allowing for targeted prevention and intervention programs. In a large global sample, COVID-19 was associated with more severe mental health symptoms compared to other stressful or traumatic events.The impact of COVID-19 on mental health differed around the world with an especially large impact in Latin America. In a large global sample, COVID-19 was associated with more severe mental health symptoms compared to other stressful or traumatic events. The impact of COVID-19 on mental health differed around the world with an especially large impact in Latin America.
Additional file 2 of CompLement C5 Antibodies for decreasing brain injury after aneurysmal Subarachnoid Haemorrhage (CLASH): study protocol for a randomised controlled phase II clinical trial
Creators: name: Koopman, Inez
name: Rinkel, Gabriel J. E.
name: Vergouwen, Mervyn D. I.
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Computational Biology

description: Additional file 2. Data management plan.
GAN Cocktail: mixing GANs without dataset access
Creators: name: Avrahami, Omri
name: Lischinski, Dani
name: Fried, Ohad
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Graphics (cs.GR)
subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: Today's generative models are capable of synthesizing high-fidelity images, but each model specializes on a specific target domain. This raises the need for model merging: combining two or more pretrained generative models into a single unified one. In this work we tackle the problem of model merging, given two constraints that often come up in the real world: (1) no access to the original training data, and (2) without increasing the size of the neural network. To the best of our knowledge, model merging under these constraints has not been studied thus far. We propose a novel, two-stage solution. In the first stage, we transform the weights of all the models to the same parameter space by a technique we term model rooting. In the second stage, we merge the rooted models by averaging their weights and fine-tuning them for each specific domain, using only data generated by the original trained models. We demonstrate that our approach is superior to baseline methods and to existing transfer learning techniques, and investigate several applications.
description: ECCV 2022. Project page is available at: https://omriavrahami.com/GAN-cocktail-page/
Confronting the Galactic Center Gamma Ray Excess With a Light Scalar Dark Matter
Creators: name: Ghosh, Dilip Kumar
name: Mondal, Subhadeep
name: Saha, Ipsita
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The Fermi Large Area Telescope observed an excess in gamma ray emission spectrum coming from the center of the Milky Way galaxy. This data reveals that a light Dark Matter (DM) candidate of mass in the range 31-40 GeV, dominantly decaying into $b\bar b$ final state, can explain the presence of the observed bump in photon energy. We try to interpret this observed phenomena by sneutrino DM annihilation into pair of fermions in the Supersymmetric Inverse Seesaw Model (SISM). This model can also account for tiny non-zero neutrino masses satisfying existing neutrino oscillation data. We show that a Higgs portal DM in this model is in perfect agreement with this new interpretation besides satisfying all other existing collider, cosmological and low energy experimental constraints.
description: 19 pages, 5 figures, version accepted for publication in JCAP
Additional file 1 of Factors affecting the use of clinical practice guidelines by hospital physicians: the interplay of IT infrastructure and physician attitudes
Creators: name: Sasaki, Noriko
name: Yamaguchi, Naohito
name: Okumura, Akiko
name: Yoshida, Masahiro
name: Sugawara, Hiroyuki
name: Shin, Jung-Ho
name: Kunisawa, Susumu
name: Imanaka, Yuichi
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Additional file 1. Table. Original core questions
Entanglement Swapping in the Transactional Interpretation of Quantum Mechanics
Creators: name: Marchildon, Louis
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The transactional interpretation of quantum mechanics, which uses retarded and advanced solutions of the Schrodinger equation and its complex conjugate, offers an original way to visualize and understand quantum processes. After a brief review, we show how it can be applied to different quantum situations, emphasizing the importance of specifying a complete configuration of absorbers. We consider in more detail the phenomenon of entanglement swapping, and see how the apparent retroactive enforcement of entanglement can be understood in the transactional interpretation.
description: Minor clarifications, references added, forthcoming in Physica Scripta
Additional file 2 of Factors affecting the use of clinical practice guidelines by hospital physicians: the interplay of IT infrastructure and physician attitudes
Creators: name: Sasaki, Noriko
name: Yamaguchi, Naohito
name: Okumura, Akiko
name: Yoshida, Masahiro
name: Sugawara, Hiroyuki
name: Shin, Jung-Ho
name: Kunisawa, Susumu
name: Imanaka, Yuichi
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Additional file 2. STROBE checklist