Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis
Creators: name: Kim, Honey
name: Langbein, Kerstin
name: Thompson, Andrew
name: Glenthøj, Louise Birkedal
name: Salinas, Cesar
name: McGorry, Patrick D
name: Carrington, Holly
name: Jacobs, Grace R
name: Tamayo, Zailyn
name: Rossum, Inge Winter-van
name: Gerber, Carla
name: Whitford, Thomas
name: Lavoie, Suzie
name: Provenzani, Umberto
name: Krcmar, Marija
name: Kim, Sung-Wan
name: Koutsouleris, Nikolaos
name: Seitz-Holland, Johanna
name: Aversa, Samantha
name: Galindo, Liliana
name: Reyes, Manuel
name: Agurto, Carla
name: Borders, Owen
name: Mamah, Daniel
name: Gur, Ruben C
name: Allott, Kelly
name: Santorelli, Gennarina
name: Fusar-Poli, Paolo
name: Markiewicz, Christopher
name: Ji, Jie Lisa
name: Ray, Susan
name: Pichiecchio, Anna
name: Kane, John M
name: Kwon, Jun Soo
name: Rogers, Jack
name: Billah, Tashrif
name: Damiani, Stefano
name: Langholm, Carsten
name: Bathery, Alyssa
name: Murty, Vishnu
name: Valle, Daniela
name: Ebdrup, Bjørn H
name: Wolff, Phillip
name: Bilgrami, Zarina
name: Bruna, Alejandro
name: Gao, Caroline
name: Lafanechere, Melanie
name: Omar, Mariam
name: Kahn, René S
name: Colton, Beau-Luke
name: Mavambu, Aissata
name: Ching, Ann Ee
name: Wang, Jijun
name: Kerins, Sarah
name: Ennis, Michaela
name: Cornblatt, Barbara A
name: Kinney, Kyle
name: Lewandowski, Kathryn E
name: Geljic, Mia
name: Suen, Yi Nam
name: Spark, Jessica
name: Mittal, Vijay A
name: Castillo-Passi, Rolando I
name: Perez, Jesus
name: Hartmann, Jessica
name: Kubicki, Marek
name: Etuka, Brandon Asika
name: Schiffman, Jason
name: Gaspar, Pablo A
name: Armando, Marco
name: Brown, Lisa
name: Marcy, Patricia J
name: Getachew, Ruth
name: Huynh, Kevin
name: Yuen, Hok Pan
name: Anticevic, Alan
name: Woods, Scott W
name: Bayer, Johanna M M
name: Ellman, Lauren M
name: Bouix, Sylvain
name: Shetty, Jashmina
name: Chung, Yoonho
name: Mayol-Troncoso, Rocío
name: Lepage, Martin
name: Poldrack, Russell
name: Reynolds, Kate
name: Alvarez-Jimenez, Mario
name: Germano, Carmela
name: Turetsky, Bruce I
name: McLaughlin, Danielle
name: Matnejl, Priya
name: Powers, Albert R
name: Nicholas, Spero C
name: McGowan, Alessia
name: Perkins, Diana O
name: Torous, John
name: Furlan, Rachel
name: Wood, Stephen J
name: Reinen, Jenna
name: Byun, Andrew
name: Formica, Melanie
name: Reichenberg, Avraham
name: Lee, Clarice
name: Srihari, Vinod H
name: Asgari-Targhi, Ameneh
name: Pearlson, Godfrey D
name: Baek, Seon-Hwa
name: Contreras, Pamela
name: Pasternak, Ofer
name: Jeffries, Clark
name: Hamilton, Holly K
name: Eichi, Habiballah Rahimi
name: Politi, Pierluigi
name: Kapur, Tina
name: Ruiz-Yu, Bernalyn
name: Rabin, Rachel
name: Nordentoft, Merete
name: Ali, Munaza
name: Youn, Sarah
name: D’Alfonso, Simon
name: Wickham, Alana
name: Birch, Sonia
name: Chen, Justine
name: Gupta, Tina
name: Do, Kim
name: Cotter, David
name: Hui, Christy Lai Ming
name: Lin, Eric
name: Broome, Matthew R
name: Mensi, Martina
name: Partridge, Alice
name: Kambeitz, Joseph
name: Adasme, Tatiana
name: Veale, Simone
name: Chakravarty, M Mallar
name: Zamorano, Francisco
name: Kerr, Melissa
name: Ahmed, Uzair
name: Cetin-Karayumak, Suheyla
name: Fadnavis, Shreyas
name: Mathalon, Daniel H
name: Estradé, Andrés
name: McQueen, Brittany
name: Diaz-Caneja, Covadonga M
name: Sabb, Fred W
name: Roalf, David R
name: Done, Monica
name: Wong, Stephanie Ming Yin
name: McIlhenny, Rebecca
name: Stone, William S
name: Coleman, Michael J
name: Tod, Sophie
name: Carrión, Ricardo E
name: Jo, Anna
name: Zinberg, Jamie
name: Light, Gregory A
name: Nelson, Barnaby
name: Conus, Philippe
name: Zavaglia, Elissa
name: Mebrahtu, Yohannes
name: Bates, Kelly
name: Wannan, Cassandra M J
name: Shah, Jai L
name: Cho, Kang Ik K
name: Corral, Sebastián
name: Lane, Erlend
name: Polosecki, Pablo
name: Goncalves, Mathias
name: Rathi, Yogesh
name: Shenton, Martha E
name: Choi, Jimmy
name: Scott, Isabelle
name: Nunez, Angela
name: Auther, Andrea
name: Walsh, Barbara C
name: Clifford, Chloe
name: Ning, Lipeng
name: Snowball, Callum
name: Cecci, Guillermo
name: Haidar, Anastasia
name: Upthegrove, Rachel
name: Mantua, Valentina
name: Adery, Laura
name: Glynn, Robert
name: Cadenhead, Kristin S
name: Yao, Beier
name: McDonnell, Amelia
name: Cahill, John
name: Liebenthal, Einat
name: Addamo, Lauren
name: Whitson, Sarah
name: Cho, Youngsun T
name: Raj, Jasmine
name: Kesselring, Irena
name: Buccilli, Kate
name: Srivastava, Agrima
name: Fonteneau, Clara
name: Rush, Sage
name: Amminger, Paul
name: Dwyer, Dominic
name: Hoftman, Gil D
name: Strauss, Gregory P
name: Zoupou, Eirini
name: Morrell, Neal
name: Baker, Justin T
name: Maturana, Alejandro
name: Lalousis, Paris Alexandros
name: Ruparel, Kosha
name: Turra-Fariña, Gabriel
name: Castro, Eduardo
name: Porter, Christian
name: Arango, Celso
name: Keshavan, Matcheri S
name: Calkins, Monica E
name: Rayner, Victoria
name: Yung, Alison R
name: Corcoran, Cheryl M
name: Bonoldi, Ilaria
name: Hendricks, Larry
name: Gur, Raquel E
name: Addington, Jean
name: Smesny, Stefan
name: Kim, Nicholas
name: Llerena, Joshua
name: Jarcho, Johanna
name: Pratt, Danielle N
name: Phassouliotis, Christina
name: Kambeitz-Ilankovic, Lana
name: Bearden, Carrie E
name: Wolf, Daniel H
name: Clark, Scott R
name: Wigman, Johanna T W
name: Beedham, Rebecca
name: Prunier, Nicholas
name: Kotler, Elana
name: Cannon, Tyrone D
name: Kohler, Christian G
name: Penzel, Nora
name: Horton, Leslie E
name: Cheng, Nicholas
name: Borgatti, Renato
name: Vangel, Mark
name: Harms, Michael P
name: Verma, Swapna
name: Chen, Eric Yu Hai
name: John, Omar
name: Mervis, Josh
Publisher: name: Oxford University Press (OUP)
Year: 2024

description: This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.