cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
5-Azacytidine Downregulates the Proliferation and Migration of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Targeting miR-139-5p/ROCK2 Pathway.
Creators: name: Tonon, Federica
name: Cemazar, Maja
name: Kamensek, Urska
name: Zennaro, Cristina
name: Pozzato, Gabriele
name: Caserta, Sergio
name: Ascione, Flora
name: Grassi, Mario
name: Guido, Stefano
name: Ferrari, Cinzia
name: Cansolino, Laura
name: Trotta, Francesco
name: Kuzmanov, Biljana Grcar
name: Forte, Giancarlo
name: Martino, Fabiana
name: Perrone, Francesca
name: Bomben, Riccardo
name: Gattei, Valter
name: Elvassore, Nicola
name: Murano, Erminio
name: Truong, Nhung Hai
name: Olson, Michael
name: Farra, Rossella
name: Grassi, Gabriele
name: Dapas, Barbara
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: hepatocellular carcinoma
5-azacytidine
cell cycle
migration
miR-139-5p
ROCK2
E2F1
MMP-2

description: BACKGROUND: For hepatocellular carcinoma (HCC), effective therapeutic approaches are lacking. As aberrant gene methylation is a major contributor to HCC development, demethylating drugs such as 5-azacytidine (5-Aza) have been proposed. As most 5-Aza mechanisms of action are unknown, we investigated its phenotypic/molecular effects. METHODS: 5-Aza effects were examined in the human HCC cell lines JHH-6/HuH-7 and in the rat cell-line N1-S1. We also employed a xenograft mouse model (HuH-7), a zebrafish model (JHH-6), and an orthotopic syngeneic rat model (N1-S1) of HCC. RESULTS: 5-Aza downregulated cell viability/growth/migration/adhesion by upregulating miR-139-5p, which in turn downregulated ROCK2/cyclin D1/E2F1 and increased p27kip1, resulting in G1/G0 cell accumulation. Moreover, a decrease in cyclin B1 and an increase in p27kip1 led to G2/M accumulation. Finally, we observed a decrease in MMP-2 levels, a stimulator of HCC cell migration. Aza effects were confirmed in the mouse model; in the zebrafish model, we also demonstrated the downregulation of tumor neo-angiogenesis, and in the orthotopic rat model, we observed impaired N1-S1 grafting in a healthy liver. CONCLUSION: We demonstrate for the first time that 5-Aza can impair HCC development via upregulation of miR-139-5p, which in turn impairs the ROCK2/cyclin D1/E2F1/cyclin B1 pro-proliferative pathway and the ROCK2/MMP-2 pro-migratory pathway. Thus, we provide novel information about 5-Aza mechanisms of action and deepen the knowledge about the crosstalk among ROCK2/cyclin D1/E2F1/cyclin B1/p27kip1/MMP-2 in HCC.
title: The new features of Fortran 202x
Creators: name: Reid, JK
Publisher: name: STFC
Year: 2022

description: The aim of this paper is to summarize the new features of the revision of Fortran 2018 that is planned for publication in 2023. It is known informally as Fortran 202x. We take as our starting point Fortran 2018 (ISO/IEC 2018) and its corrigendum (ISO/IEC 2021). For an informal description of Fortran 2018, see Metcalf, Reid and Cohen (2018).
Guidelines for the implementation of scientific publishing policies of research data citation in scientific publications and assuring access to primary data, used in publications
Creators: name: Štebe, Janez
name: Bezjak, Sonja
name: Dolinar, Maja
Publisher: name: Zenodo
Year: 2020
Subjects: Research Data Policy
Scientific Publishing

description: Preparation of Guidelines for the formulation of scientific publishing policies of citing research data in scientific publications and for providing access to primary data on which scientific discussions are based is one of the goals of the Research Data Alliance (RDA) Node Slovenia. The Guidelines are intended for scientific publishers and editors of scientific journals to assist them in policy-making of the so-called open access to research data requirements as a starting point for the preparation of any journal-adapted guidance for authors, reviewers and editors. They are accompanied by an example of detailed instructions for authors, to which editorial boards may refer to authors when preparing their instructions and, where appropriate, direct authors to extract from their guidelines independent Explanations for understanding the policies of scientific publishers in providing access to primary data used in articles. We thank the Working Group of the RDA Node Slovenia and all participating representatives of the editorial offices for their comments and suggestions.
Laporan Praktikum 1 Divisi Pinophyta Kelas Nurul Fajriyah (180101111088) (Revisi)
Creators: name: Fajriyah, Nurul
Publisher: name: Zenodo
Year: 2020

description: Assalamu'alaikum ibu dan kakak-kakak, Ulun: Nama: Nurul Fajriyah NIM: 180101111088 ini laporan praktikum ulun yang ke 1, mohon maaf atas banyak kekurangannya dan terima kasih. Wassalamu'alaikum.
Laporan Praktikum 1 Nurul Fajriyah (180101111088)
Creators: name: Fajriyah, Nurul
Publisher: name: Zenodo
Year: 2020

description: Assalamu'alaikum ibu dan kakak-kakak, Ulun: Nama: Nurul Fajriyah NIM: 180101111088 ini laporan praktikum ulun yang ke 1, mohon maaf atas banyak kekurangannya dan terima kasih. Wassalamu'alaikum.
Go! Pasia. Strategia wejścia i działania Uniwersytetu Ekonomicznego w Poznaniu na rynku azjatyckim.doc
Creators: name: Swajan Das
Publisher: name: figshare
Year: 2015
Subjects: Education
Economics

description: Temat pracy magisterskiej Go! Pasia. Strategia wejścia i działania Uniwersytetu Ekonomicznego w Poznaniu na rynku azjatyckim. .Autor w swojej pracy magisterskiej przedstawił strategię wejścia na rynek, a także strategię rozwoju w 15 państwach azjatyckich, podzielonych na 5 identycznych rynków, w celu zwiększenia zainteresowania studentów międzynarodowych ofertą edukacyjną Uniwersytetu Ekonomicznego w Poznaniu. W pracy przedstawiono znaczenie w/w strategii, a także zaprezentowano badania statystyczne dotyczące przemieszczania się studentów międzynarodowych w każdym kraju w ostatnich 12 latach (2001-1012). Zidentyfikowano indywidualne zachowania rynkowe, pozycję konkurencyjną Polski oraz głównych konkurentów na poziomie Europy, Poznania oraz ich zachowania na poziomie kraju. Po rozpoznaniu czynników konkurencyjności na poziomie kraju, miasta, instytucji i programu, autor opracował strategię pozycjonowania Uniwersytetu Ekonomicznego w Poznaniuna rynki docelowe. W niniejszej pracy magisterskiej znajduje się także odwołanie do „Strategii Uniwersytetu Ekonomicznego w Poznaniu na lata 2013-2020”, gdzie internacjonalizacja Uczelni jest jednym z głównych celów. W swojej pracy, autor wskazał obszary w Strategii, bardzo ważne w kontekście zwiększenia konkurencyjności oraz liczby studentów międzynarodowych. Opracowanie może być wykorzystane również przez inne uczelnie albo jednostki edukacyjne w Poznaniu.
School culture and student mental health: a qualitative study in UK secondary schools.
Creators: name: Jessiman, Patricia
name: Kidger, Judi
name: Spencer, Liam
name: Geijer-Simpson, Emma
name: Kaluzeviciute, Greta
name: Burn, Anne-Marie
name: Leonard, Naomi
name: Limmer, Mark
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Research
School culture
School climate
Mental health
Qualitative
Children
Young people

description: BACKGROUND: There is consistency of evidence on the link between school culture and student health. A positive school culture has been associated with positive child and youth development, effective risk prevention and health promotion efforts, with extensive evidence for the impact on student mental health. Interventions which focus on socio-cultural elements of school life, and which involve students actively in the process, are increasingly understood to be important for student mental health promotion. This qualitative study was undertaken in three UK secondary schools prior to the implementation of a participative action research study bringing students and staff together to identify changes to school culture that might impact student mental health. The aim was to identify how school culture is conceptualised by students, parents and staff in three UK secondary schools. A secondary aim was to explore which components of school culture were perceived to be most important for student mental health. METHODS: Across three schools, 27 staff and seven parents participated in in-depth interviews, and 28 students participated in four focus groups. The Framework Method of thematic analysis was applied. RESULTS: Respondents identified elements of school culture that aligned into four dimensions; structure and context, organisational and academic, community, and safety and support. There was strong evidence of the interdependence of the four dimensions in shaping the culture of a school. CONCLUSIONS: School staff who seek to shape and improve school culture as a means of promoting student mental health may have better results if this interdependence is acknowledged, and improvements are addressed across all four dimensions.
description: National Institute for Health Research (NIHR) School for Public Health Research (Grant Reference Number PD–SPH–2015).
Laporan Praktikum 2 Hellyatunisa (180101110229)
Creators: name: Hellyatunisa
Publisher: name: Zenodo
Year: 2020

description: Assalamualaikum mohon maaf ganggu waktunya bu ini saya Hellyatunisa dari kelompok 2 ingin mengirim tugas Laporan Praktikum 1 terima kasih banyak bu wassalamualaikum
Schuchertoceras fryi Kröger 2013, sp. nov.
Creators: name: Kröger, Björn
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Cephalopoda
Ascocerida
Ascoceratidae
Schuchertoceras
Schuchertoceras fryi

description: Schuchertoceras fryi sp. nov.
urn:lsid:zoobank.org:act: BA02C2EE-982A-483B-90DF-46E5E5F80FD4
Figs 10F, 39F
Schuchertoceras troedssoni – Frye 1982: 1280, pl. 1, fig. 3 (non pl. 1, figs 1, 2, 5).
Diagnosis
Schuchertoceras with gibbous mature conch with slightly depressed cross section, a basal septum and one ascocerid septum, a highly convex septum of truncation and a mature body chamber height of ca. 40 mm.
Etymology
Refers to Mark W. Frye, who first described some of the ascocerids of the Boda Limestone (Frye 1982).
Holotype
PMU 24744.
Type locality and horizon
Kallholn, Dalarna, Sweden, Boda Limestone, Boda Core Member, late Katian, Ordovician.
Description
The specimen is a complete fragment of a mature conch. The outer shell is partially preserved and nearly smooth with fine, irregularly spaced growth lines. The total conch length is 65 mm and the maximum height of 40 mm and width of 44 mm (ratio width/height 1.1) are reached at approximately mid-length of the mature body chamber (Fig. 39F). The length/height ratio of the mature conch is 0.61. The aperture is depressed, elliptical in cross section, with a height of 32 mm and a width of ca. 36 mm. The septum of truncation is highly convex and dome-shaped, with a height of ca. 14 mm and oblique. The septal perforation is close to the conch margin (ca. 5 mm). The ascocerid septum forms a short and pointed lobe and a wide and shallow sinus and almost reaches the aperture on the antisiphuncular side of the conch. The prosiphuncular side is slightly flattened in cross section (Fig. 10F).
Remarks
This specimen was assigned to Schuchertoceras troedssoni Frye, 1982 by Frye (1982: 1280) and described as an “unusually gibbous, and nearly egg-like” specimen. A reinvestigation of the specimens described by Frye (1982) reveals that PMU d727 is not only significantly larger than the other specimens assigned to S. troedssoni, which have a mature length of 40–50 mm only, but differs in having a highly convex septum of truncation. This is in strong contrast to the type of S. troedssoni, which possesses a relatively shallow and flat septum of truncation and which is clearly less gibbous in general conch form. These differences are considered to be significant here and justify the erection of a new species for this specimen.
Stratigraphic and geographic range
Boda Limestone, late Katian, Dalarna, Sweden.
description: Published as part of Kröger, Björn, 2013, The cephalopods of the Boda Limestone, Late Ordovician, of Dalarna, Sweden, pp. 1-110 in European Journal of Taxonomy 41 on pages 84-86, DOI: 10.5852/ejt.2013.41, http://zenodo.org/record/3814221
Laporan Praktikum 2 Divisi Magnoliphyta Anak Kelas Magnoliidae Nurul Fajriyah (180101111088) (Revisi)
Creators: name: Fajriyah, Nurul
Publisher: name: Zenodo
Year: 2020

description: Assalamu'alaikum ibu dan kakak-kakak, Ulun: Nama: Nurul Fajriyah NIM: 180101111088 ini laporan praktikum ulun yang ke 2, mohon maaf atas banyak kekurangannya dan terima kasih. Wassalamu'alaikum.
Laporan Praktikum 2 Divisi Magnoliphyta Anak Kelas Magnoliidae Nurul Fajriyah (180101111088)
Creators: name: Fajriyah, Nurul
Publisher: name: Zenodo
Year: 2020

description: Assalamu'alaikum ibu dan kakak-kakak, Ulun: Nama: Nurul Fajriyah NIM: 180101111088 ini laporan praktikum ulun yang ke 2, mohon maaf atas banyak kekurangannya dan terima kasih. Wassalamu'alaikum.
High-Throughput Analysis of Foodborne Bacterial Genomic DNA Using Agilent 2200 TapeStation and Genomic DNA ScreenTape System
Creators: name: Jeannotte, Richard
name: Lee, Eric
name: Knog, Nguyet
name: Ng, Whitney
name: Storey, Dylan
name: Weimer, Bart
name: Kelly, Lenore
Publisher: name: figshare
Year: 2015
Subjects: Molecular Biology

description: The initial step in Next Generation Sequencing is to construct a library from and genomic DNA. To gain the optimum result, extracted DNA must be of high molecular weight with limited degradation. High-throughput sequencing projects, such as the 100K Pathogen Genome Project, require methods to rapidly assess the quantity and quality of genomic DNA extracts. In this study, assessment of the applicability of the TapeStation was done using genomic DNA from nine foodborne pathogens using several accepted high-throughput methods. The Agilent 2200 TapeStation System with Genomic DNA ScreenTape and Genomic DNA Reagents
was easy to use with minimal manual intervention. An important advantage of the
2200 TapeStation over other high-throughput methods was that high molecular
weight genomic DNA quality and quantity can be quantified apart from lower molec-
ular weight size ranges, providing a distinct advantage in the library construction
pipeline and over other methods available for this important step in the Next
Generation Sequencing process.
Flexure Behaviors of ABS-based Composites Containing Carbon and Kevlar Fibers by Material Extrusion 3D Printing
Creators: name: Wang, Kui
name: Li, Shixian
name: Rao, Yanni
name: Wu, Yiyun
name: Peng, Yong
name: Yao, Song
name: Zhang, Honghao
name: Ahzi, Said
Publisher: name: Manara - Qatar Research Repository
Year: 2024
Subjects: classificationCode: 40
subject: Engineering
classificationCode: 4016
subject: Materials engineering
subject: FOS: Materials engineering

description: Short-fiber-reinforced thermoplastics are popular for improving the mechanical properties exhibited by pristine thermoplastic materials. Due to the inherent conflict between strength and ductility, there are only a few successful cases of simultaneous enhancement of these two properties in polymer composite components. The objective of this work was to explore the feasibility of simultaneous enhancement of strength and ductility in ABS-based composites with short-carbon and Kevlar fiber reinforcement by material extrusion 3D printing (ME3DP). Microstructure characterization and measurement of thermal and mechanical properties were conducted to evaluate the fiber-reinforced ABS. The influence of printing raster orientation and build direction on the mechanical properties of material extrusion of 3D-printed composites was analyzed. Experimental results demonstrated that the reinforcement of the ABS-based composites by short-carbon and Kevlar fibers under optimized 3D-printing conditions led to balanced flexural strength and ductility. The ABS-based composites with a raster orientation of ±45° and side build direction presented the highest flexural behaviors among the samples in the current study. The main reason was attributed to the printed contour layers and the irregular zigzag paths, which could delay the initiation and propagation of microcracks.Other InformationPublished in: Polymers
License: https://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://doi.org/10.3390/polym11111878
Laporan 2 Divisi Magnoliophyta Kelas Magnoliopsida Anak Kelas Magnoliidae
Creators: name: Suaidah
Publisher: name: Zenodo
Year: 2020

description: Assalamualaikum wr.wb nama: Suaidah ingin mengumpul laporan praktikum 2 Divisi Magnoliophyta Kelas Magnoliopsida Anak Kelas Magnoliidae
Optimization of Covaris Settings for Shearing Bacterial Genomic DNA by Focused Ultrasonication and Analysis Using Agilent 2200 TapeStation
Creators: name: Jeannottee, Richard
name: Lee, Eric
name: Arabyan, Narine
name: Kong, Nguyet
name: Kao Thao
name: Huang, Carol
name: Storey, Dylan
name: Weimer, Bart
name: Kelly, Lenore
Publisher: name: figshare
Year: 2015
Subjects: Molecular Biology

description: Shearing of bacterial gDNA within a specific size range prior to sequencing library
construction is a critical step in Next Generation Sequencing workflows. The quality
control of the sheared bacterial gDNA is required in large multiplexed formats for
large volume workflows, such as those used in the 100K Pathogen Genome
Sequencing Project. Using the Covaris E220 instrument, the power and treatment
time were varied to determine the effect on the optimal fragment size (150–350 bp)
in the resulting sheared gDNA of four bacterial pathogens: Salmonella enterica
subsp. enterica serovar Saint Paul strain Sp3 and serovar Typhimurium strain LT2,
Klebsiella sp. and Vibrio spp. DNA fragment quantification and sizing were mea-
sured using an Agilent 2200 TapeStation system, and Agilent High Sensitivity D1000
ScreenTape assay. The 2200 TapeStation system was suitable to determine size dis-
tribution after fragmentation of gDNA in a 96-well plate format, a format suitable for high-throughput workflow and compatible with shearing technologies that use a 96-well plate multiplexed format. This approach enabled the measurement of gDNA
and sheared DNA using a single technology.
Rapid Detection of Actinobacillus pleuropneumoniae From Clinical Samples Using Recombinase Polymerase Amplification.
Creators: name: Stringer, Oliver W
name: Li, Yanwen
name: Bossé, Janine T
name: Forrest, Matthew S
name: Hernandez-Garcia, Juan
name: Tucker, Alexander W
name: Nunes, Tiago
name: Costa, Francisco
name: Mortensen, Preben
name: Velazquez, Eduardo
name: Penny, Paul
name: Rodriguez-Manzano, Jesus
name: Georgiou, Pantelis
name: Langford, Paul R
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Veterinary Science
A. pleuropneumoniae
RPA (recombinase polymerase amplification)
apxIVA
point-of-care (POC)
FTA® card

description: Actinobacillus pleuropneumoniae (APP) is the causative agent of porcine pleuropneumonia, resulting in high economic impact worldwide. There are currently 19 known serovars of APP, with different ones being predominant in specific geographic regions. Outbreaks of pleuropneumonia, characterized by sudden respiratory difficulties and high mortality, can occur when infected pigs are brought into naïve herds, or by those carrying different serovars. Good biosecurity measures include regular diagnostic testing for surveillance purposes. Current gold standard diagnostic techniques lack sensitivity (bacterial culture), require expensive thermocycling machinery (PCR) and are time consuming (culture and PCR). Here we describe the development of an isothermal point-of-care diagnostic test - utilizing recombinase polymerase amplification (RPA) for the detection of APP, targeting the species-specific apxIVA gene. Our APP-RPA diagnostic test achieved a sensitivity of 10 copies/μL using a strain of APP serovar 8, which is the most prevalent serovar in the UK. Additionally, our APP-RPA assay achieved a clinical sensitivity and specificity of 84.3 and 100%, respectively, across 61 extracted clinical samples obtained from farms located in England and Portugal. Using a small subset (n = 14) of the lung tissue samples, we achieved a clinical sensitivity and specificity of 76.9 and 100%, respectively) using lung imprints made on FTA cards tested directly in the APP-RPA reaction. Our results demonstrate that our APP-RPA assay enables a suitable rapid and sensitive screening tool for this important veterinary pathogen.
Performance of early warning signals for disease re-emergence: A case study on COVID-19 data.
Creators: name: Proverbio, Daniele
name: Kemp, Françoise
name: Magni, Stefano
name: Gonçalves, Jorge
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: subject: Research Article
subject: Medicine and health sciences
subject: Physical sciences
subject: FOS: Physical sciences
subject: Computer and information sciences
subject: FOS: Computer and information sciences
subject: Engineering and technology
subject: FOS: Engineering and technology
subject: Research and analysis methods
subject: People and places

description: Developing measures for rapid and early detection of disease re-emergence is important to perform science-based risk assessment of epidemic threats. In the past few years, several early warning signals (EWS) from complex systems theory have been introduced to detect impending critical transitions and extend the set of indicators. However, it is still debated whether they are generically applicable or potentially sensitive to some dynamical characteristics such as system noise and rates of approach to critical parameter values. Moreover, testing on empirical data has, so far, been limited. Hence, verifying EWS performance remains a challenge. In this study, we tackle this question by analyzing the performance of common EWS, such as increasing variance and autocorrelation, in detecting the emergence of COVID-19 outbreaks in various countries. Our work illustrates that these EWS might be successful in detecting disease emergence when some basic assumptions are satisfied: a slow forcing through the transitions and not-fat-tailed noise. In uncertain cases, we observe that noise properties or commensurable time scales may obscure the expected early warning signals. Overall, our results suggest that EWS can be useful for active monitoring of epidemic dynamics, but that their performance is sensitive to certain features of the underlying dynamics. Our findings thus pave a connection between theoretical and empirical studies, constituting a further step towards the application of EWS indicators for informing public health policies.
MitoQ Prevents Human Breast Cancer Recurrence and Lung Metastasis in Mice.
Creators: name: Capeloa, Tania
name: Krzystyniak, Joanna
name: Rodriguez, Amanda Canas
name: Payen, Valéry L
name: Zampieri, Luca X
name: Pranzini, Erica
name: Derouane, Françoise
name: Vazeille, Thibaut
name: Bouzin, Caroline
name: Duhoux, François P
name: Murphy, Mike
name: Porporato, Paolo E
name: Sonveaux, Pierre
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Mitochondria
Breast cancer
Metastasis
Translational Research
Mitochondria-targeted Antioxidant
Mitoq
Mitochondrial Superoxide
Metastasis Prevention
Cancer Relapse

description: In oncology, the occurrence of distant metastases often marks the transition from curative to palliative care. Such outcome is highly predictable for breast cancer patients, even if tumors are detected early, and there is no specific treatment to prevent metastasis. Previous observations indicated that cancer cell mitochondria are bioenergetic sensors of the tumor microenvironment that produce superoxide to promote evasion. Here, we tested whether mitochondria-targeted antioxidant MitoQ is capable to prevent metastasis in the MDA-MB-231 model of triple-negative human breast cancer in mice and in the MMTV-PyMT model of spontaneously metastatic mouse breast cancer. At clinically relevant doses, we report that MitoQ not only prevented metastatic take and dissemination, but also local recurrence after surgery. We further provide in vitro evidence that MitoQ does not interfere with conventional chemotherapies used to treat breast cancer patients. Since MitoQ already successfully passed Phase I safety clinical trials, our preclinical data collectively provide a strong incentive to test this drug for the prevention of cancer dissemination and relapse in clinical trials with breast cancer patients.
Kappa-Opioid Receptor Blockade Ameliorates Obesity Caused by Estrogen Withdrawal via Promotion of Energy Expenditure through mTOR Pathway.
Creators: name: Romero-Picó, Amparo
name: Novelle, Marta G
name: Al-Massadi, Omar
name: Beiroa, Daniel
name: Tojo, Marta
name: Heras, Violeta
name: Ruiz-Pino, Francisco
name: Senra, Ana
name: López, Miguel
name: Blouet, Clemence
name: Tena-Sempere, Manuel
name: Nogueiras, Rubén
name: Diéguez, Carlos
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Estrogens
Obesity
Energy Expenditure
P70s6k
Kappa-opioid
Animals
Humans
Mice
Body Weight
Weight Gain
Receptors, Opioid, kappa
Ovariectomy
Energy Metabolism
Eating
Female
Adipose Tissue, Brown
TOR Serine-Threonine Kinases

description: Weight gain is a hallmark of decreased estradiol (E2) levels because of menopause or following surgical ovariectomy (OVX) at younger ages. Of note, this weight gain tends to be around the abdomen, which is frequently associated with impaired metabolic homeostasis and greater cardiovascular risk in both rodents and humans. However, the molecular underpinnings and the neuronal basis for these effects remain to be elucidated. The aim of this study is to elucidate whether the kappa-opioid receptor (k-OR) system is involved in mediating body weight changes associated with E2 withdrawal. Here, we document that body weight gain induced by OVX occurs, at least partially, in a k-OR dependent manner, by modulation of energy expenditure independently of food intake as assessed in Oprk1-/-global KO mice. These effects were also observed following central pharmacological blockade of the k-OR system using the k-OR-selective antagonist PF-04455242 in wild type mice, in which we also observed a decrease in OVX-induced weight gain associated with increased UCP1 positive immunostaining in brown adipose tissue (BAT) and browning of white adipose tissue (WAT). Remarkably, the hypothalamic mTOR pathway plays an important role in regulating weight gain and adiposity in OVX mice. These findings will help to define new therapies to manage metabolic disorders associated with low/null E2 levels based on the modulation of central k-OR signaling.
Website
Creators: name: IND-AGRO-POL
Publisher: name: Zenodo
Year: 2022

description: As part of task 5.2 “Website and media promotion”, the project website was designed and created with the aim of being a primary point of reference for up-to-date information on project partners, activities and results, providing information related to the project, main objectives and results, and acting as a communication channel for the target audience and a gateway for the CXC IT Tool. Aimed at developing a group of active members, the project website is also integrated with the project profiles on social media and the project newsletter.
Techniques and Tools: Effectiveness of Research-based Pedagogical Techniques through Online Learning Tools with Secondary Students
Creators: name: Dolphy, Leia
Publisher: name: figshare
Year: 2015
Subjects: Education

description: With the rapid growth of the online learning environment (OLE), many teachers face the challenge of teaching effectively in this new environment. This study examined online secondary teachers’ opinions of the effectiveness of various researched-based pedagogical techniques (RPT) implemented through online learning tools on student participation, academic achievement, and satisfaction. The purpose is to help teachers improve how they may use online learning tools effectively for RPT application. The data were collected through an online survey distributed to participants in the fall of 2014. The findings showed that online secondary teachers most frequently used the online learning tools blogs, discussion boards, and interactive tutorials/modules. Wikis, virtual worlds, and social network sites were rarely used in online secondary classes and had the most reported barriers for use. Not seeing the potential of the online learning tool was found to be the most common barrier, along with the inability of a course management software (CMS) to implement a tool. This study concludes that there are generally positive relationships between online learning tools with RPT and student participation, academic achievement, and satisfaction in online secondary courses. Online secondary teachers need training and support to implement tools with RPT found effective in literature. It is recommended that more research be conducted to look at the relationship between the effectiveness, frequency of use, and barriers, as well as examine how other participant demographics may impact the data.
VCIOM-SPUTNIK Poll: September 2019
Creators: name: VCIOM (Russian Public Opinion Research Center)
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: President of Russia approval (1); Prime Minister approval (1); State Duma of Russia (2); political party preference (2); mass protests (2); Internet usage (1); watch TV (1); trade unions (1); judicial system (1); Russian Orthodox church (1); personal financial situation (2); employment (2); sources of income (1); most important problems (5); rise in prices, inflation (2); Russian ruble and US dollar exchange rate fluctuations (3); unemployment (2); take out loans (2); spend or save money (1); savings (1); economic policy (1); social policy (1); foreign policy (1); direction of country (1); life satisfaction (2).
Front-ends to Biomedical Data Analysis on Grids
Creators: name: Shahand, Shayan
name: Santcroos, Mark
name: Yassene Mohammed
name: Korkhov, Vladimir
name: Luyf, Angela C. M.
name: Kampen, Antoine H. C. Van
name: Sílvia D. Olabarriaga
Publisher: name: figshare
Year: 2015
Subjects: subject: Computer Engineering
subject: Computer Software
subject: FOS: Computer and information sciences
subject: Distributed Computing
subject: Applied Computer Science

description: Because the Proceedings of the HealthGrid 2011 conference has not published yet, this paper is uploaded to Figshare.
Clarifying Misunderstandings, Moving Forward: Towards Standards and Tools for Set-Theoretic Methods
Creators: name: Rohlfing, Ingo
name: Schneider, Carsten Q.
Publisher: name: figshare
Year: 2015
Subjects: subject: Sociology
subject: FOS: Sociology

description: This is a response by Carsten Q. Schneider and me to the criticial QCA-symposium in the Newsletter of the APSA Section on Qualitative and Multi-Method Research, volume 12, issue 1. A reply by David Collier to our contribution has been announced for volume 13, issue 1 of the newsletter.
Probillingsites Foerste 1928
Creators: name: Kröger, Björn
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Cephalopoda
Ascocerida
Ascoceratidae
Probillingsites

description: Genus Probillingsites Foerste, 1928
Type species
Probillingsites welleri Foerste, 1928, Wisconsin, USA; probably Galena Dolomite, early-mid Katian, Ordovician; by original designation.
Emended diagnosis
Cyrtocones with truncated conch; mature conch inflated, higher than long or height similar to length; conch cross section circular to depressed; mature sutures generally oblique and slightly sinuous or sigmoid, but not lacunose; septal necks in latest septa strongly recumbent, cyrtochoanitic, in earlier septa suborthocoanitic; siphuncular segments expanded.
Remarks
The morphology of Probillingsites scandinavicum sp. nov. indicates that the concept of Probillingsites requires adjustment as it is transitional between Redpathoceras and typical Probillingsites. In fact, the distinction between Redpathoceras and Probillingsites must be drawn relatively arbitrarily at the tenuous border between a mature body chamber characterized as “strongly inflated” (Probillingsites) or “inflated” (Redpathoceras), or between a mature truncated conch that is “obese” (Probillingsites) or breviconic (Redpathoceras). The ratio of the height/length of the mature conch may be used as a quantitative measure to distinguish between the two genera. In Redpathoceras clarki Flower, 1963, the type of Redpathoceras, this ratio is 0.48 and in R. magum sp. nov. and R. bullatum it is 0.46; in typical Probillingsites the height is greater than or equal to the length. In P. scandinavicum sp. nov. this ratio is 0.52. Consequently, here Probillingsites is restricted to Probillingsitidae with conch heights that are greater than or equal to the mature conch length.
description: Published as part of Kröger, Björn, 2013, The cephalopods of the Boda Limestone, Late Ordovician, of Dalarna, Sweden, pp. 1-110 in European Journal of Taxonomy 41 on pages 86-87, DOI: 10.5852/ejt.2013.41, http://zenodo.org/record/3814221
Jakie miasto widać na widokówce?
Creators: name: Kowalewski, Maciej
Publisher: name: figshare
Year: 2015
Subjects: subject: Sociology
subject: FOS: Sociology

description: Jakie miasto widać na widokówce? [w:] Wizualność miasta. Wytwarzanie miejskiej ikonosfery, red. M. Krajewski, seria Badania Interdyscyplinarne nr 10, wyd. UAM, Poznań, s. 137-147
title: Activation of the ISIS synchrotron room air
Creators: name: Jones, B
name: Burns, Gordon
name: Cavanagh, H
name: Findlay, D J S
name: Karbassi, S
name: Nilsson, N
name: Skoro, Goran
name: Wright, PNM
Publisher: name: STFC
Year: 2021

description: Between February 2018 and February 2020, measurements were made of the activity of the air in the ISIS synchrotron room using a shielded HPGe gamma-ray detector located well outside the synchrotron room, air from the synchrotron room being piped to the detector through a long length of air ducting hose. Overall, more than two thousand separate gamma-ray spectra were recorded. Specific activities were obtained for 7Be, 11C, 13N, 38Cl, 39Cl, 40Cl and 41Ar, likely radionuclide production routes were identified, and radiation dose rates from submersion in synchrotron room air were obtained. In addition, analyses of many neutron-capture lines were made.
Response of Amaranthus hybridus to metal stress and manure amendment in contaminated soil
Creators: name: Iqbal, Zahid
name: Raymond A. Wuana1*,
name: Mbasugh2, Phoebe A.
name: Iorungwa1, Moses S.
Publisher: name: figshare
Year: 2015
Subjects: subject: Soil Science
subject: Education
subject: Environmental Humanities
subject: Environmental Science
subject: Environmental Chemistry
subject: Ecology
subject: FOS: Biological sciences

description: The effects of heavy metal contamination and manure amendment in soil on the growth of green Amaranthus hybridus were studied by pot experiments. A mineral soil was stressed with different doses (100 – 500 mg kg-1) of Cu and Pb using a binary mixture of the metal nitrates and/or amended with poultry or swine manure (at 10:1 soil:manure ratio). A. hybridus was sown and monitored for changes in growth rate, above-ground dry biomass and tissue Cu and Pb concentration for 49 days. A. hybridus was seemingly intolerant to metal stress as the plants exhibited yellowish appearance, stunted growth and decreased biomass at elevated metal doses in soil, though with reduced severity upon manure (especially poultry) amendment. Growth profiles were sigmoid at lower metal doses (0 – 300 mg kg-1) but plateau-like at higher doses (400 – 500 mg kg-1). Tissue Cu and Pb increased linearly as metal doses in unamended soils and non-linearly in manure-amended soils. Soil-to-plant transfer factors, f (%), indicated that Cu (11.2 ≤ f (%) ≤ 41.1) was more phytoavailable to A. hybridus than Pb (8.4 ≤ f (%) ≤ 17.0). Step-wise modeling of tissue Cu and Pb concentrations from soil pH, organic matter, plant available and pseudototal metal content by multiple regression analysis suggested that the models were more reliable with plant available metal as a covariate than pseudototal metal content.
Supplementary Material
Creators: name: Patil, Akash
name: Le Friec, Yannick
name: Roussel, Pascal
name: Deblock, Yves
name: Jeannot, Simon
name: Boivin, Philippe
name: Dubois, Emmanuel
name: Robillard, Jean-François
Publisher: name: AIP Publishing
Year: 2024
Subjects: classificationCode: 51
subject: Physical sciences
subject: FOS: Physical sciences

description: Calibration coefficients for GGST and GGSTN, Measurement approach-errors, Hotspot temperature, Material properties, Resistivity data
Probillingsites scandinavicum Kröger 2013, sp. nov.
Creators: name: Kröger, Björn
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Cephalopoda
Ascocerida
Ascoceratidae
Probillingsites
Probillingsites scandinavicum

description: Probillingsites scandinavicum sp. nov.
urn:lsid:zoobank.org:act: 42510E86-B2FE-40F7-8ED5-319BD939BDD4
Fig. 39 D-E
Diagnosis
Probillingsites with a smooth mature conch with depressed conch cross section; conch margins in longitudinal view convex on prosiphuncular side and concave on antisiphuncular side; maximum conch height of ca. 55 mm at mid-length of body chamber; septa of mature conch slightly oblique; sutures nearly straight.
Etymology
Refers to the larger type area; this is only the second species of Probillingsites known from the region.
Holotype
PMU 26922.
Type locality and horizon
Kallholn, Dalarna, Sweden, Boda Limestone, Boda Core Member, late Katian, Ordovician.
Description
The specimen is a nearly complete fragment of a mature conch, with a length of ca. 105 mm. The height of the septum of truncation is 39 mm and the apertural height is ca. 40 mm. The maximum height of 55 mm of the conch is approximately at mid-length of the body chamber, where the width is 59 mm (width/height ratio 1.07) (Fig. 39D, F). In cross-section the prosiphuncular side is more rounded, the prosiphuncular side slightly flattened. The aperture is constricted and depressed with an elliptical cross-section. The conch surface is poorly preserved but appears to be ornamented with fine, irregularly spaced growth lines.
The phragmocone is ca. 35 mm long and consists of four chambers. The septa are simple convex and slightly oblique, projecting toward the aperture on the antisiphuncular side. The septum of truncation is relatively shallow with a depth of ca. 6 mm.
Comparison
This species is unique amongst the known species of Probillingsites in having only simple straight septa in the mature conch, a relatively long body chamber and a shallow convex septum of truncation.
Stratigraphic and geographic range
Boda Limestone, late Katian, Dalarna, Sweden.
description: Published as part of Kröger, Björn, 2013, The cephalopods of the Boda Limestone, Late Ordovician, of Dalarna, Sweden, pp. 1-110 in European Journal of Taxonomy 41 on pages 87-88, DOI: 10.5852/ejt.2013.41, http://zenodo.org/record/3814221
Shipping decarbonisation shout for new technologies: developing passive air lubrication
Creators: name: Oeffner, Johannes
name: Weisheit, Jonathan
name: Schimmel, Thomas
name: Walheim, Stefan
name: Jalkanen, Jukka-Pekka
name: Oikonomou, Fotis
Publisher: name: Zenodo
Year: 2022
Subjects: maritime
emissions
hull management
shipping
decarbonisation

description: To achieve the greenhouse gas (GHG) emissions reduction goal of achieving net zero by 2050 as outlined in the European Green Deal, the maritime shipping industry must reduce emissions: 50% by 2030 and 90% by 2050. This cannot be achieved by a single measure alone. Ship resistance reduction measures (via advanced coatings, air lubrication, hull management of biofouling, hull form design) are necessary drivers available to reduce emissions today. Ship owners cannot alone focus on alternative fuels, which will not be available in the medium-term in large quantities, and slow steaming which is well understood but will increase delivery times and the number of ships needed for transport. Therefore, the need for resistance reduction measures is high now. The AIRCOAT project advances a bio-inspired green solution to create an air layer on ship hulls under water, so-called ‘air lubrication’, with the aim to reduce drag and to prevent biofouling, thus reducing fuel consumption and emissions. To realise market-ready innovative solution, longer research time-frames and incremental funding are necessary to allow for further improvements on real-world testing that is appropriate for the two-decade life cycle of ships.
Structure and composition estimation of plant species around Khoh river of Garhwal Himalaya, India
Creators: name: Iqbal, Zahid
name: Kaiser Iqbal
name: Jahangeer A. Bhat*
name: Pala, Nazir A.
Publisher: name: figshare
Year: 2015
Subjects: subject: Education
subject: Environmental Humanities
subject: Environmental Science
subject: Environmental Chemistry
subject: Solid Earth Sciences
subject: Ecology
subject: FOS: Biological sciences

description: The present study was carried out along the Khoh river of Garhwal Himalaya with the aim to assess the species composition and diversity of plant species between the forest vegetation along the river and the forest, which was away from the river. Vegetational analysis was carried out by quadrat sampling method and a total of 30 quadrates along the river and 30 quadrates away from the river were laid out randomly and the size of quadrat was 10 m × 10 m. Salix tetraseprma tree species emerged as a dominant species along riverian vegetation with highest IVI (38.07) and highest density (1.03 trees/100m2) values. The highest density values in shrubs and herb species were recorded for Trachelospermum lucidum and Polygala erioptera respectively. In the forest vegetation, located away from the river, Toona hexandra was found dominant species with IVI and density values 34.52 and 0.66 trees/100m2 respectively and in shrub layer, the highest density was observed for Uraria rufescens and in herbs the highest density was recorded for Persicaria capitata. Tree species diversity was observed highest along the river while the lowest tree diversity was away from the river.
Foreword
Creators: name: Amziane, Sofiane
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: Welcome to this Special Issue of Academic Journal of Civil Engineering related to the conference organized each year by AUGC (The University - Association of Civil Engineering). The 34th meeting of universities in civil engineering has been organised by AUGC and the department ArGEnCo (Architecture, Geology, Environment and Construction) of the University of Liège were held in Liège (Belgium) from 25 to 27 May 2016 under the general theme: Building the city of the future.
description: Academic Journal of Civil Engineering, Vol 34 No 1 (2016): Special Issue - RUGC 2016 Liège
Redpathoceras Flower 1963
Creators: name: Kröger, Björn
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Cephalopoda
Ascocerida
Probillingsitidae
Redpathoceras

description: Genus Redpathoceras Flower, 1963
Type species
Redpathoceras clarki Flower, 1963, northeast of Joliette, Quebec, Canada; Leray Limestone, early-mid Katian, Ordovician; by original designation.
Diagnosis
Gyrocones with circular to depressed mature conch cross section; mature body chamber inflated with greatest diameter at approximate mid-length; broad shallow hyponomic sinus; septum of truncation deeply rounded; suture of septa in mature specimen slightly oblique, sloping in adoral direction on concave side of conch curvature; siphuncle eccentric, close to conch margin at convex side of conch curvature. (Adopted from Flower 1963.)
Remarks
Redpathoceras was assigned to the Probillingsitidae by Flower (1963) because of its deeply rounded septum of truncation and its inflated mature body chamber. The type species, Redpathoceras clarki, is characterized by a mature shell with only two chambers adoral of the terminal truncation; this is similar to Probillingsites. Some specimens of Redpathoceras from the Boda Limestone have mature truncated shells with five chambers (Redpathoceras magnus sp. nov.); this is very similar to Montyoceras Flower, 1941, and supports Flower’s (1963) hypothesis of an ancestry of Billingsites and other ascocerids from a Montyoceras -like form. (The truncated parts of premature Redpathoceras phragmocones consist of ca. seven to eight chambers.)
On the other hand, the strongly curved conch portions of Redpathoceras are very similar to some uranoceratids, such as Deckeroceras Foerste, 1935, Siljanoceras gen. nov. and Warburgoceras gen. nov., from which it mainly differs in having a deeply convex septum of truncation. This suggests a relationship of Uranoceratidae with ascocerids (see discussion below).
The shape of the septal necks and connecting ring of the species of Redpathoceras known from the Boda Limestone are similar to those of Probillingsites (compare with Furnish & Glenister 1964a: fig. 189.4; Fig. 40 A-C). The connecting ring is slightly expanded in juvenile chambers and nummoidal and strongly expanded in the latest chambers. The septal necks are suborthochoanitic in juvenile stages and distally thickened and achoanitic in the latest stages.
Stratigraphic and geographic range
Leray Limestone, early-mid Katian, Quebec, Canada; Boda Limestone, late Katian, Dalarna, Sweden.
description: Published as part of Kröger, Björn, 2013, The cephalopods of the Boda Limestone, Late Ordovician, of Dalarna, Sweden, pp. 1-110 in European Journal of Taxonomy 41 on page 88, DOI: 10.5852/ejt.2013.41, http://zenodo.org/record/3814221
When hydrogen bond tailors molecular packing in non-anisometric molecules. The case study of N-alkyl 1,3-diphenyl-4,5-dihydro-1H-pyrazole-5-carboximidamides
Creators: name: Kotian, Sumana Y.
name: D, Shridevi
name: Ningaiah, Srikantamurthy
name: Merlo, Aloir A.
name: Vieira, André A.
name: Bechtold, Ivan H.
name: Lokanatha, K. M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 60506 Virology

description: In this paper, we report the synthesis of novel liquid crystals (LCs) based on 5-membered pyrazoline heterocycle. The synthesis of pyrazoline derivative was carried out by [3 + 2] 1,3-dipolar cycloaddition reaction of benzaldehyde phenyl hydrazone (1) with acrylonitrile, mediated by chloramine-T as the oxidising agent, followed by addition of hydroxylamine hydrochloride, and subsequently alkylated with various alkyl chains to afforded the title compounds. The LCs properties were investigated using differential scanning calorimetry and polarising optical microscopy. For title compounds with longer alkyl chains, monotropic columnar hexagonal mesophase was characterised by XRD analysis. The mesophase-formation was driven by intermolecular hydrogen bonds despite their non-discoid molecular structure.
Economic circumstances of children living in higher and lower educated families and the contribution of household structure: Comparison of 11 European countries
Creators: name: Heiskala, Laura
name: Tuominen, Minna
name: Erola, Jani
name: Kilpi-Jakonen, Elina
Publisher: name: Mapineq deliverables. Turku: INVEST Research Flagship Centre / University of Turku
Year: 2024
Subjects: Children's economic circumstances
Household structure
Geospatial inequalities

description: We study the contribution of household structure to the educational group income gap with cross-nationally comparable GGS data, including also regional information. We extend our perspective and unit of analysis from adults to children living in the households and study differences in children’s economic circumstances between higher and lower-educated families in multiple national and regional contexts. We aim to distinguish the contribution of household structure to the education group income gap and study whether there is geographical variation in how much this explains the education group differences in children’s economic circumstances. More specifically, we ask: 1) how much are the differences in economic circumstances of children living in higher and lower-educated households due to differences in household structure? And 2) does this vary between European countries and regions?