cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Chemo-Mechanical Elastic Modeling of Carcinoma Development
Creators: name: D. A. Bratsun
name: A. P. Zakharov
name: L. M. Pismen
Publisher: name: Advanced Biomaterials and Devices in Medicine
Year: 2016
Subjects: cancer modeling
signaling
circadian rhythms
time-delay
systems biology

description: We propose a multiscale chemo-mechanical model of the cancer tumor development in the epithelial tissue. The epithelium is represented by an elastic 2D array of polygonal cells with its own gene regulation dynamics. The cell morphology was calibrated in the model based on the experimental data. The model allows for the simulation of the evolution of multiple cells interacting via the chemical signaling or mechanically induced strain. The used algorithm takes into account the division and intercalation of cells, as well as the transition of normal cells into a cancerous state triggered by a local failure of spatial synchronization of cellular rhythms driven by transcription/translation processes. Both deterministic and stochastic descriptions of the system are given for chemical signaling. The simulations reproduce a distinct behavior of invasive and localized carcinoma. Generally, the model is designed in such a way that it can be readily adjusted to take into account any newly understood gene regulation processes or feedback mechanisms affecting chemo-mechanical properties of cells.
Flavor deformations and supersymmetry enhancement in $4d$ $\mathcal{N}=2$ theories
Creators: name: Naseer, Usman
name: Thull, Charles
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study $\mathcal{N}=2$ theories on four-dimensional manifolds that admit a Killing vector $v$ with isolated fixed points. It is possible to deform these theories by coupling position-dependent background fields to the flavor current multiplet. The partition function of the deformed theory only depends on the value of the background scalar fields at the fixed points of $v$. For a single adjoint hypermultiplet, the partition function becomes independent of the supergravity as well as the flavor background if the scalars attain special values at the fixed points. For these special values, supersymmetry at the fixed points enhances from the Donaldson-Witten twist to the Marcus twist or the Vafa-Witten twist of $\mathcal{N}=4$ SYM. Our results explain the recently observed squashing independence of $\mathcal{N}=2^*$ theory on the squashed sphere and provide a new squashing independent point. Interpreted through the AGT-correspondence, this implies the $b$-independence of torus one-point functions of certain local operators in Liouville/Toda CFT. The position-dependent deformations imply relations between correlators of partially integrated operators in any $\mathcal{N}=2$ SCFT with flavor symmetries.
description: 23+11 pages. Typos fixed
The relationship between soil fertility, phosphorus uptake, and crop yields of paddy (Oryza sativa l.) under different farming systems of rice field
Creators: name: Mujiyo Mujiyo
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2024
Subjects: Inorganic
Nutrients uptake
Organic farming
Land management impact

description: Asia-Pacific Journal of Science and Technology, 29, 5, 10 (11 pages)
Gap labeling theorem for multilayer thin film heterostructures
Creators: name: Yoshii, Mao
name: Kitamura, Sota
name: Morimoto, Takahiro
Publisher: name: arXiv
Year: 2022
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Quasiperiodic systems show a universal gap structure due to quasiperiodicity which is analogous to gap openings at the Brillouin zone boundary in periodic systems. The integrated density of states (IDoS) below those energy gaps are characterized by a few integers, which is known as the ``gap labeling theorem'' (GLT) for quasiperiodic systems. In this study, focusing on multilayer thin film systems such as twisted bilayer graphene and stacked transition metal dichalcogenides, we extend the GLT for multilayer systems of arbitrary dimensions and number of layers, using an approach based on the algebra called ``a noncommutative torus''. We find that the energy gaps and the associated IDoS are generally characterized by $_{DN}C_D$ integer labels in $N$ layer systems in the $D$ dimensions, when the effect of the interlayer coupling can be approximated by a quasiperiodic intralayer coupling for each layer. We demonstrate that the generalized GLT holds for quasiperiodic 1D tight binding models by numerical simulations.
description: 12 pages, 4 figures
Epitope specificity determines pathogenicity and detectability in ANCA-associated vasculitis
Creators: name: Winnik, Witold
name: van Timmeren, Mirjan M.
name: Roth, Aleeza J.
name: Heeringa, Peter
name: Hogan, Susan L.
name: Poulton, Caroline E.
name: Preston, Gloria A.
name: Ooi, Joshua D.
name: Stegeman, Coen A.
name: Niles, John
name: Burkart, Madelyn
name: Hu, Yichun
name: Hess, Jacob J.
name: McGregor, JulieAnne
name: Nachman, Patrick H.
name: Kitching, A. Richard
name: Jennette, J. Charles
name: Holdsworth, Stephen
name: Falk, Ronald J.
name: Berg, Elisabeth A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Anti-neutrophil cytoplasmic antibody–associated (ANCA-associated) small vessel necrotizing vasculitis is caused by immune-mediated inflammation of the vessel wall and is diagnosed in some cases by the presence of myeloperoxidase-specific antibodies (MPO-ANCA). This multicenter study sought to determine whether differences in ANCA epitope specificity explain why, in some cases, conventional serologic assays do not correlate with disease activity, why naturally occurring anti-MPO autoantibodies can exist in disease-free individuals, and why ANCA are undetected in patients with ANCA-negative disease. Autoantibodies from human and murine samples were epitope mapped using a highly sensitive epitope excision/mass spectrometry approach. Data indicated that MPO autoantibodies from healthy individuals had epitope specificities different from those present in ANCA disease. Importantly, this methodology led to the discovery of MPO-ANCA in ANCA-negative disease that reacted against a sole linear sequence. Autoantibodies against this epitope had pathogenic properties, as demonstrated by their capacity to activate neutrophils in vitro and to induce nephritis in mice. The confounder for serological detection of these autoantibodies was the presence of a fragment of ceruloplasmin in serum, which was eliminated in purified IgG, allowing detection. These findings implicate immunodominant epitopes in the pathology of ANCA-associated vasculitis and suggest that autoantibody diversity may be common to other autoimmune diseases.
Polymer based scaffolds for tissue regeneration by stereolithography
Creators: name: A. Ronca
name: L. Ambrosio
Publisher: name: Advanced Biomaterials and Devices in Medicine
Year: 2017
Subjects: stereolithography
rapid prototyping
biomaterials
tissue engineering
scaffolds

description: Stereolithography is a rapid prototyping technique, introduced in the 1980s, that enables the realization of complex 3D structures for tissue engineering directly from a computer model. Although many other 3D printing techniques have been developed over the last decades, it has the highest fabrication accuracy and an increasing number of materials that can be processed is becoming available. In this review we present the characteristic features of the stereolithography technique and the design of polymers (of both synthetic and natural origin) with tailored structure, architecture, and functionality for stereolithography to mimic a broad range of human tissues. In addition, the use of two-photon polymerization for the production of tissue engineering scaffolds with smaller-scale features than those typical of the conventional stereolithography technology is described.
Lepton Flavor Violation in Flavored Gauge Mediation
Creators: name: Calibbi, Lorenzo
name: Paradisi, Paride
name: Ziegler, Robert
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the anatomy and phenomenology of Lepton Flavor Violation (LFV) in the context of Flavored Gauge Mediation (FGM). Within FGM, the messenger sector couples directly to the MSSM matter fields with couplings controlled by the same dynamics that explains the hierarchies in the SM Yukawas. Although the pattern of flavor violation depends on the particular underlying flavor model, FGM provides a built-in flavor suppression similar to wave function renormalization or SUSY Partial Compositeness. Moreover, in contrast to these models, there is an additional suppression of left-right (LR) flavor transitions by third-generation Yukawas that in particular provides an extra protection against flavor-blind phases. We exploit the consequences of this setup for lepton flavor phenomenology, assuming that the new couplings are controlled by simple U(1) flavor models that have been proposed to accommodate large neutrino mixing angles. Remarkably, it turns out that in the context of FGM these models can pass the impressive constraints from LFV processes and leptonic EDMs even for light superpartners, therefore offering the possibility of resolving the longstanding muon g-2 anomaly.
description: 32 pages, 7 figures
The low Sr/Ba ratio on some extremely metal-poor stars
Creators: name: Spite, M.
name: Spite, F.
name: Bonifacio, P.
name: Caffau, E.
name: François, P.
name: Sbordone, L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: It has been noted that, in classical extremely metal-poor (EMP) stars, the abundance ratio of Sr and Ba, is always higher than [Sr/Ba] = -0.5, the value of the solar r-only process; however, a handful of EMP stars have recently been found with a very low Sr/Ba ratio. We try to understand the origin of this anomaly by comparing the abundance pattern of the elements in these stars and in the classical EMP stars. Four stars with very low Sr/Ba ratios were observed and analyzed within LTE approximation through 1D (hydrostatic) model atmosphere, providing homogeneous abundances of nine neutron-capture elements. In CS 22950-173, the only turnoff star of the sample, the Sr/Ba ratio is, in fact, found to be higher than the r-only solar ratio, so the star is discarded. The remaining stars (CS 29493-090, CS 30322-023, HE 305-4520) are cool evolved giants. They do not present a clear carbon enrichment. The abundance patterns of the neutron-capture elements in the three stars are strikingly similar to a theoretical s-process pattern. This pattern could at first be attributed to pollution by a nearby AGB, but none of the stars presents a clear variation in the radial velocity indicating the presence of a companion. The stellar parameters seem to exclude any internal pollution in a TP-AGB phase for at least two of these stars. The possibility that the stars are early-AGB stars polluted during the core He flash does not seem compatible with the theory.
description: Accepted for publication in Astronomy and Astrophysics
Investigation of the neutron imaging applications using fine-grained nuclear emulsion
Creators: name: Muneem, Abdul
name: Yoshida, Junya
name: Ekawa, Hiroyuki
name: Hino, Masahiro
name: Hirota, Katsuya
name: Ichikawa, Go
name: Kasagi, Ayumi
name: Kitaguchi, Masaaki
name: Muto, Naoto
name: Mishima, Kenji
name: Nabi, Jameel-Un
name: Nakagawa, Manami
name: Naganawa, Naotaka
name: Saito, Takehiko R.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Neutron imaging is a non-destructive inspection technique with a wide range of applications. One of the important aspects concerning neutron imaging is achieving micrometer-scale spatial resolution. Developing a neutron detector with a high resolution is a challenging task. Neutron detectors, based on fine-grained nuclear emulsion, may be suitable for high resolution neutron imaging applications. High track density is a necessary requirement to improve the quality of neutron imaging. However, the available track analysis methods are difficult to apply under high track density conditions. Simulated images were used to determine the required track density for neutron imaging. It was concluded that a track density of the order of $10^4$ tracks per 100 $\times$ 100 $μ$m$^2$ is sufficient to utilize neutron detectors for imaging applications. The contrast resolution was also investigated for the image data sets with various track densities and neutron transmission rates. Moreover, experiments were performed for neutron imaging of the gadolinium-based gratings with known geometries. The structure of gratings was successfully resolved. The calculated 1$σ$ 10-90 \% edge response, using the gray scale optical images of the grating slit with a periodic structure of 9 $μ$m, was 0.945 $\pm$ 0.004 $μ$m.
Isoscalar electromagnetic form factors of the nucleon in $N_\mathrm{f} = 2 + 1$ lattice QCD
Creators: name: Djukanovic, Dalibor
name: von Hippel, Georg
name: Meyer, Harvey B.
name: Ottnad, Konstantin
name: Salg, Miguel
name: Wilhelm, Jonas
name: Wittig, Hartmut
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We present results for the isoscalar electromagnetic form factors of the nucleon computed on the Coordinated Lattice Simulations (CLS) ensembles with $N_\mathrm{f} = 2 + 1$ flavors of $\mathcal{O}(a)$-improved Wilson fermions and an $\mathcal{O}(a)$-improved conserved vector current. In order to estimate the excited-state contamination, we employ several source-sink separations and apply the summation method. For the computation of the quark-disconnected diagrams, a stochastic estimation based on the one-end trick is performed, in combination with a frequency-splitting technique and the hopping parameter expansion. By these means, we obtain a clear signal for the form factors including the quark-disconnected contributions, which have a statistically significant effect on our results.
description: 9 pages, 5 figures, contribution to the 38th International Symposium on Lattice Field Theory (LATTICE21), 26th-30th July 2021, Zoom/Gather@Massachusetts Institute of Technology; enlarged font size in figures
Biomaterials and regenerative medicine in the treatment of cancer
Creators: name: C. J. Kirkpatrick
Publisher: name: Advanced Biomaterials and Devices in Medicine
Year: 2017
Subjects: cancer
biomaterials
regenerative medicine
3D-models
nanomedicine

description: Cancer continues to be a field of medical research and practice demanding complex and expensive forms of therapy, many of which still involve the systemic administration of chemotherapeutic agents. This latter form of treatment carries with it many complications and unwanted side-effects. Unfortunately, up until now relatively few research groups in the biomaterials field have focussed their attention on oncology, with the result that a number of innovative developments, which could benefit cancer patients, have remained in the realm of non-oncological regenerative medicine. Of special interest for oncology is the progress which has been made in the development of interactive and responsive biomaterials, as these can be tuned to release signal molecules or therapeutic agents in response to a local microenvironment. This strategy has the double advantage of local release of anti-cancer agents and at the same time modulation of the healing response in the affected tissues. To achieve such functionality many advances, especially in polymer chemistry, but also in ceramics and metals, have led to the development of suitable targeted biomaterials. This has been greatly assisted by innovations in nanotechnology, including the versatility of core-shell nanoparticles for nanomedicine. For the latter a number of in vitro models, especially of barrier systems in the human body have been devised as models for targeted therapy. Moreover, modem biodegradable, responsive hydrogels could be used along with complex models for tumour biology, such as three-dimensional (3D) spheroid culture systems, which can be applied to investigate, for example, the processes of invasion and the role of inflammation in cancer. The necessity for suitable models to address biomechanical aspects represents a further issue of importance in oncological research and combines the expertise of both physics and biology. Finally, the complex field of mechanobiology can only be successfully addressed by interdisciplinary research activity.
Cosmological constraints from the power spectrum of eBOSS quasars
Creators: name: Chudaykin, Anton
name: Ivanov, Mikhail M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present the effective-field theory (EFT)-based cosmological full-shape analysis of the anisotropic power spectrum of eBOSS quasars at the effective redshift $z_{\rm eff}=1.48$. We perform extensive tests of our pipeline on simulations, paying a particular attention to the modeling of observational systematics, such as redshift smearing, fiber collisions, and the radial integral constraint. Assuming the minimal $Λ$CDM model, and fixing the primordial power spectrum tilt and the physical baryon density, we find the Hubble constant $H_0=(66.7\pm 3.2)~$km~s$^{-1}$Mpc$^{-1}$, the matter density fraction $Ω_m=0.32\pm 0.03$, and the late-time mass fluctuation amplitude $σ_8=0.95\pm 0.08$. These measurements are fully consistent with the Planck cosmic microwave background results. Our eBOSS quasar $S_8$ posterior, $0.98\pm0.11$, does not exhibit the so-called $S_8$ tension. Our work paves the way for systematic full-shape analyses of quasar samples from future surveys like DESI.
description: 19+2 pages, 13 figures, 6+2 tables; v2: Appendix F added, matched version accepted by Phys. Rev. D
Oscillatory Exchange Bias Controlled by RKKY in Magnetic Multilayers
Creators: name: Polishchuk, D. M.
name: Persson, M.
name: Kulyk, M. M.
name: Baglioni, G.
name: Ivanov, B. A.
name: Korenivski, V.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Ferromagnetic/antiferromagnetic bilayers are interfaced with normal metal/ferromagnetic bilayers to form F*/AF/N/F valves. The N-spacer thickness is chosen such that it mediates strong indirect exchange (RKKY) between the outer magnetic layers, which varies in strength/direction depending on the N thickness and in direction on switching F. The system exhibits a strong modulation of the F*/AF exchange bias, oscillating in strength syncronously with the oscillation in the interlayer RKKY exchange across the normal metal spacer. The effect is explained as due to a superposition taking place within the antiferromagnetic layer of the direct-exchange proximity effect from the F*/AF interface and the indirect RKKY exchange from F penetrating AF via N. The modulation, expressed via the strength of the F*/AF bias field, reaches 400% at the first RKKY peak.
description: 5 pages, 4 figures
Detecting Lagrangian coherent structures from sparse and noisy trajectory data
Creators: name: Mowlavi, Saviz
name: Serra, Mattia
name: Maiorino, Enrico
name: Mahadevan, L
Publisher: name: arXiv
Year: 2021
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Dynamical Systems (math.DS)
subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Many complex flows such as those arising from ocean plastics in geophysics or moving cells in biology are characterized by sparse and noisy trajectory datasets. We introduce techniques for identifying Lagrangian Coherent Structures (LCSs) of hyperbolic and elliptic nature in such datasets. Hyperbolic LCSs, which represent surfaces with maximal attraction or repulsion over a finite amount of time, are computed through a regularized least-squares approximation of the flow map gradient. Elliptic LCSs, which identify regions of coherent motion such as vortices and jets, are extracted using DBSCAN - a popular data clustering algorithm - combined with a systematic approach to choose parameters. We deploy these methods on various benchmark analytical flows and real-life experimental datasets ranging from oceanography to biology and show that they yield accurate results, despite sparse and noisy data. We also provide a lightweight computational implementation of these techniques as a user-friendly and straightforward Python code.
description: 26 pages, 12 figures
Effects of polyhydroxy compounds on the properties of starch-protein composites modified by high-pressure processing
Creators: name: Wilailuk Chaiyasit
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2024
Subjects: High-pressure processing
HPP
Starch-protein composite
Polyhydroxy compound

description: Asia-Pacific Journal of Science and Technology, 29, 5, 12 (10 pages)
Sub-stellar engulfment by a main sequence star: where is the lithium?
Creators: name: Cabezón, Rubén M.
name: Abia, Carlos
name: Domínguez, Inma
name: García-Senz, Domingo
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: In this work, we study whether the engulfment of a brown dwarf (BD) by a solar-like main-sequence (MS) star can significantly alter the structure of the star and the Li content on its surface. We perform 3D Smoothed Particle Hydrodynamics simulations of the engulfment of a BD with masses 0.01 and 0.019 Msun, onto an MS star of 1 Msun and solar composition, in three different scenarios: a head-on collision, a grazing collision, and a merger. We study the dynamics of the interaction in detail, and the relevance of the type of interaction and the mass of the BD on the final fate of the sub-stellar object and the host star in terms of mass loss of the system, angular momentum transfer, and changes in the Li abundance in the surface of the host star. We found that most of the BD mass is diluted in the denser region of the MS star. Only in the merger scenario a significant fraction (40%) of the BD material would remain in the outer layers. We find a clear increase in the surface rotational velocity of the host star after the interaction, ranging between 25 km/s (grazing collision) to 50 km/s (merger). We also find a significant mass loss from the system (1e-4 - 1e-3 Msun) due to the engulfment, which in the case of the merger, may form a circumstellar disk-like structure. Assuming that neither the depth of the convective envelope of the host star nor its mass content are modified during the interaction, a small change in the surface Li abundance in the head-on and grazing collisions is found. However, in the merger we find large Li enhancements, by factors 20-30, depending on the BD mass. Some of these features could be detected observationally in the host star provide they remain long enough time.
description: 18 pages, 16 figures, accepted for publication in Astronomy & Astrophysics
ErbB3 downregulation enhances luminal breast tumor response to antiestrogens
Creators: name: Massarweh, Suleiman
name: Stanford, Jamie C.
name: Perou, Charles M.
name: Prat, Aleix
name: Morrison, Meghan M.
name: Williams, Andrew J.
name: Balko, Justin M.
name: Earp, H. Shelton
name: Hutchinson, Katherine
name: Arteaga, Carlos L.
name: Young, Christian
name: Williams, Michelle M.
name: Sánchez, Violeta
name: Kuba, Maria G.
name: Hicks, Donna J.
name: Cook, Rebecca S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Aberrant regulation of the erythroblastosis oncogene B (ErbB) family of receptor tyrosine kinases (RTKs) and their ligands is common in human cancers. ErbB3 is required in luminal mammary epithelial cells (MECs) for growth and survival. Since breast cancer phenotypes may reflect biological traits of the MECs from which they originate, we tested the hypothesis that ErbB3 drives luminal breast cancer growth. We found higher ERBB3 expression and more frequent ERBB3 gene copy gains in luminal A/B breast cancers compared with other breast cancer subtypes. In cell culture, ErbB3 increased growth of luminal breast cancer cells. Targeted depletion of ErbB3 with an anti-ErbB3 antibody decreased 3D colony growth, increased apoptosis, and decreased tumor growth in vivo. Treatment of clinical breast tumors with the antiendocrine drug fulvestrant resulted in increased ErbB3 expression and PI3K/mTOR signaling. Depletion of ErbB3 in fulvestrant-treated tumor cells reduced PI3K/mTOR signaling, thus decreasing tumor cell survival and tumor growth. Fulvestrant treatment increased phosphorylation of all ErbB family RTKs; however, phospho-RTK upregulation was not seen in tumors treated with both fulvestrant and anti-ErbB3. These data indicate that upregulation of ErbB3 in luminal breast cancer cells promotes growth, survival, and resistance to fulvestrant, thus suggesting ErbB3 as a target for breast cancer treatment.
Вечное возвращение
Creators: name: Антипов Сергей Сергеевич
Publisher: name: Философская школа
Year: 2017
Subjects: КОСМОС
СУДЬБА
ПУТЬ
ЛЮБОВЬ
КВАНТ БЫТИЯ
ГОСПОДЬ
МОЛИТВА
НАДЕЖДА
МЕЧТА
ПЕРЕХОД
ВЕРА

description: В плеяде современных российских поэтов, работающих в стиле неоклассики, и принадлежащих к течению «Нового Ренессанса», поэтический голос Сергея Антипова выделяется, прежде всего, искренностью интонации и широтой диапазона чувств. От шепота молитвы до гневного обличения социальных пороков и нравственных изъянов ближнего окружения. На этом пути у поэта есть как несомненные удачи, так и досадные промахи, связанные с декларативностью и жесткой прямолинейностью нравственной оценки. Философские стихи Сергея Антипова удивительный пример необычного поэтического эксперимента. Под маской прямоты лирического высказывания и простоты поэтической формы скрывается необычная для нашего времени философия постэклектики многомерного восприятия бытия. Перед нами микс любовной лирики, социального протеста и философии реального поступка в рамках православного восприятия реальности. Лирический герой Сергея Антипова выражает новейшее в нашей поэзии ощущение мозаичного сознания, когда на глазах читателя, благодаря философскому дискурсу, лирический герой трансформируется в лирических типаж.
Evaluation of transdermal patches made from Garcinia mangostana Linn. peel extract and natural rubber
Creators: name: Thanakorn Damsud
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2024
Subjects: Transdermal patch
Natural rubber
Physical characterization
Garcinia mangostana Linn.

description: Asia-Pacific Journal of Science and Technology, 29, 5, 13 (6 pages)
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 6 (67)]
Creators: name: Franciscus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1427
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Francischus de Bursis, Sohn des Jacobus, praepositus und administrator des Klosters St. Cataldi, gelegen außerhalb der Mauern von Cremona, verpachtet dem Johannes del Cagna, dominus del Ceruto und Sohn des verstorbenen Laurencius, aus der Nachbarschaft St. Crucis in Cremona, mehrere Ländereien, gelegen in Cremona.
M dwarfs in the b201 tile of the VVV survey: Colour-based Selection, Spectral Types and Light Curves
Creators: name: Rojas-Ayala, Bárbara
name: Iglesias, Daniela
name: Minniti, Dante
name: Saito, Roberto K.
name: Surot, Francisco
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The intrinsically faint M dwarfs are the most numerous stars in the Galaxy, have main-sequence lifetimes longer than the Hubble time, and host some of the most interesting planetary systems known to date. Their identification and classification throughout the Galaxy is crucial to unravel the processes involved in the formation of planets, stars and the Milky Way. The ESO Public Survey VVV is a deep near-IR survey mapping the Galactic bulge and southern plane. The VVV b201 tile, located in the border of the bulge, was specifically selected for the characterisation of M dwarfs. We used VISTA photometry to identify M dwarfs in the VVV b201 tile, to estimate their subtypes, and to search for transit-like light curves from the first 26 epochs of the survey. UKIDSS photometry from SDSS spectroscopically identified M dwarfs was used to calculate their expected colours in the $YJHK_s$ VISTA system. A colour-based spectral subtype calibration was computed. Possible giants were identified by a $(J-K_s, H_{J})$ reduced proper motion diagram. The light curves of 12.8
description: 11 pages, 4 figures. Accepted for publication in Catalogs and data of Astronomy and Astrophysics
Non-analyticity in Holographic Complexity near Critical points
Creators: name: Sood, Uday
name: Kruczenski, Martin
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The region near a critical point is studied using holographic models of second-order phase transitions. In a previous paper, we argued that the quantum circuit complexity of the vacuum ($C_0$) is the largest at the critical point. When deforming away from the critical point by a term $\int d^d x \, τ\, O_Δ$ the complexity $C(τ)$ has a piece non-analytic in $τ$, namely $C_0 -C(τ) \sim |τ-τ_c|^{ν(d-1)} + \mathrm{analytic} $. Here, as usual, $ν=\frac{1}{d-Δ}$ and $ξ$ is the correlation length $ξ\sim |τ-τ_c|^{-ν}$ and there are possible logarithmic corrections to this expression. That was derived using numerical results for the Bose-Hubbard model and general scaling considerations. In this paper, we show that the same is valid in the case of holographic complexity providing evidence that the results are universal, and at the same time providing evidence for holographic computations of complexity.
description: 31 pages, 2 figures, Latex. References added
Fetal-derived adrenomedullin mediates the innate immune milieu of the placenta
Creators: name: Fritz-Six, Kimberly L.
name: Mack, Christopher P.
name: Kadmiel, Mahita
name: Willcockson, Helen H.
name: Li, Manyu
name: Espenschied, Scott T.
name: Schwerbrock, Nicole M.J.
name: Lenhart, Patricia M.
name: Christine, Kathleen S.
name: Kraus, Daniel M.
name: Caron, Kathleen M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The remodeling of maternal uterine spiral arteries (SAs) is an essential process for ensuring low-resistance, high-capacitance blood flow to the growing fetus. Failure of SAs to remodel is causally associated with preeclampsia, a common and life-threatening complication of pregnancy that is harmful to both mother and fetus. Here, using both loss-of-function and gain-of-function genetic mouse models, we show that expression of the pregnancy-related peptide adrenomedullin (AM) by fetal trophoblast cells is necessary and sufficient to promote appropriate recruitment and activation of maternal uterine NK (uNK) cells to the placenta and ultimately facilitate remodeling of maternal SAs. Placentas that lacked either AM or its receptor exhibited reduced fetal vessel branching in the labyrinth, failed SA remodeling and reendothelialization, and markedly reduced numbers of maternal uNK cells. In contrast, overexpression of AM caused a reversal of these phenotypes with a concomitant increase in uNK cell content in vivo. Moreover, AM dose-dependently stimulated the secretion of numerous chemokines, cytokines, and MMPs from uNK cells, which in turn induced VSMC apoptosis. These data identify an essential function for fetal-derived factors in the maternal vascular adaptation to pregnancy and underscore the importance of exploring AM as a biomarker and therapeutic agent for preeclampsia.
如何做调研
Creators: name: Breezedeus
Publisher: name: Zenodo
Year: 2020
Subjects: 调研

description: 介绍了不同层面的调研该怎么做,包括竞品调研,针对某个具体应用的方案调研,针对某个算法(任务)方向的调研。同时介绍了一些常用的调研工具。 对应的 B站分享视频 。 Also can be found: https://github.com/breezedeus/LoveShare .
HIF1α and HIF2α independently activate SRC to promote melanoma metastases
Creators: name: Duncan, Lyn M.
name: Kim, William Y.
name: Simon, M. Celeste
name: Hanna, Sara C.
name: Bailey, Sean T.
name: O’Brien, E. Tim
name: Moschos, Stergios J.
name: Superfine, Richard
name: Miller, C. Ryan
name: Shimamura, Takeshi
name: Wong, Kwok-Kin
name: Siegel, Marni B.
name: Kuan, Pei-Fen
name: Osborne, Lukas D.
name: Krishnan, Bhavani
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Malignant melanoma is characterized by a propensity for early lymphatic and hematogenous spread. The hypoxia-inducible factor (HIF) family of transcription factors is upregulated in melanoma by key oncogenic drivers. HIFs promote the activation of genes involved in cancer initiation, progression, and metastases. Hypoxia has been shown to enhance the invasiveness and metastatic potential of tumor cells by regulating the genes involved in the breakdown of the ECM as well as genes that control motility and adhesion of tumor cells. Using a Pten -deficient, Braf -mutant genetically engineered mouse model of melanoma, we demonstrated that inactivation of HIF1α or HIF2α abrogates metastasis without affecting primary tumor formation. HIF1α and HIF2α drive melanoma invasion and invadopodia formation through PDGFRα and focal adhesion kinase–mediated (FAK-mediated) activation of SRC and by coordinating ECM degradation via MT1-MMP and MMP2 expression. These results establish the importance of HIFs in melanoma progression and demonstrate that HIF1α and HIF2α activate independent transcriptional programs that promote metastasis by coordinately regulating cell invasion and ECM remodeling.
Short-term impact of mini-marathon running on alteration of blood lipoproteins
Creators: name: Anupharb Seesangboon
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2024
Subjects: Mini-marathon
Lipoprotein
Blood
HLD
LDL
Running

description: Asia-Pacific Journal of Science and Technology, 29, 5, 14 (6 pages)
Interaction-induced connectivity of disordered two-particle states
Creators: name: Krimer, D. O.
name: Flach, S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study the interaction-induced connectivity in the Fock space of two particles in a disordered one-dimensional potential. Recent computational studies showed that the largest localization length $ξ_2$ of two interacting particles in a weakly random tight binding chain is increasing unexpectedly slow relative to the single particle localization length $ξ_1$, questioning previous scaling estimates. We show this to be a consequence of the approximate restoring of momentum conservation of weakly localized single particle eigenstates, and disorder-induced phase shifts for partially overlapping states. The leading resonant links appear among states which share the same energy and momentum. We substantiate our analytical approach by computational studies for up to $ξ_1 = 1000$. A potential nontrivial scaling regime sets in for $ ξ_1 \approx 400$, way beyond all previous numerical attacks.
description: 5 pages, 4 figures
A New Data Compression Method and its Application to Cosmic Shear Analysis
Creators: name: Asgari, Marika
name: Schneider, Peter
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Future large scale cosmological surveys will provide huge data sets whose analysis requires efficient data compression. Calculating accurate covariances is extremely challenging with increasing number of statistics used. Here we introduce a formalism for achieving efficient data compression, based on a local expansion of statistical measures around a fiducial cosmological model. We specifically apply and test this approach for the case of cosmic shear statistics. We demonstrate the performance of our approach, using a Fisher analysis on cosmic shear tomography described in terms of E-/B-mode separating statistics (COSEBIs). We show that our data compression is highly effective in extracting essentially the full cosmological information from a strongly reduced number of observables. Specifically, the number of statistics needed decreases by at least one order of magnitude relative to the COSEBIs, which already compress the data substantially compared to the shear two-point correlation functions. The efficiency appears to be affected only slightly if a highly inaccurate covariance is used for defining the compressed statistics, showing the robustness of the method. We conclude that an efficient data compression is achievable and that the number of compressed statistics depends on the number of model parameters. In addition, we study how well band powers can be obtained from measuring shear correlation functions over a finite interval of separations. We show the strong limitations on the possibility to construct top-hat filters in Fourier space, for which the real-space analog has a finite support, yielding strong bounds on the accuracy of band power estimates. The error on an estimated band-power is larger for a narrower filter and a smaller angular range which for relevant cases can be as large as 10%.
description: 10 pages, 6 figures
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 6 (68)]
Creators: name: Uberti, Joannes
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1427
Subjects: subject: Bischofsurkunde
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Joannes Uberti, Bischof von Mantua, princeps delegatus Papst Martins V. und commissarius des apostolischen Stuhls sowie executor specialiter deputatus, legt dem Theophilus, prior des Klosters St. Benedicti in Polirone, ein Schreiben des Papstes vor, auf Grundlage dessen er strittige Eigentums- und Zuständigkeitsfragen zwischen Theophilus und Guido Gonzaga, protonotarius und commendatarius dieses Klosters, regelt.
Langevin picture of anomalous diffusion processes in expanding medium
Creators: name: Wang, Xudong
name: Chen, Yao
Publisher: name: arXiv
Year: 2022
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Expanding medium is very common in many different fields, such as biology and cosmology. It brings a nonnegligible influence on particle's diffusion, which is quite different from the effect of an external force field. The dynamic mechanism of particle's motion in expanding medium has only been investigated in the framework of continuous-time random walk. To focus on more diffusion processes and physical observables, we build the Langevin picture of anomalous diffusion in expanding medium, and conduct detailed analyses in the framework of Langevin equation. With the help of a subordinator, both subdiffusion process and superdiffusion process in expanding medium are discussed. We find that the expanding medium with different changing rate (exponential form and power-law form) leads to quite different diffusion phenomena. The particle's intrinsic diffusion behavior also plays an important role. Our detailed theoretical analyses and simulations present a panoramic view of investigating anomalous diffusion in expanding medium under the framework of Langevin equation.
description: 14 pages, 7 figures
Human iPS cellâ€“derived alveolar epithelium repopulates lung extracellular matrix
Creators: name: Mendez, Julio J.
name: Calle, Elizabeth A.
name: Bove, Peter F.
name: Balestrini, Jenna
name: Ghaedi, Mahboobe
name: Gard, Ashley L.
name: Booth, Adam
name: Niklason, Laura E.
name: White, Eric S.
name: Gui, Liqiong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The use of induced pluripotent stem cells (iPSCs) has been postulated to be the most effective strategy for developing patient-specific respiratory epithelial cells, which may be valuable for lung-related cell therapy and lung tissue engineering. We generated a relatively homogeneous population of alveolar epithelial type II (AETII) and type I (AETI) cells from human iPSCs that had phenotypic properties similar to those of mature human AETII and AETI cells. We used these cells to explore whether lung tissue can be regenerated in vitro. Consistent with an AETII phenotype, we found that up to 97% of cells were positive for surfactant protein C, 95% for mucin-1, 93% for surfactant protein B, and 89% for the epithelial marker CD54. Additionally, exposing induced AETII to a Wnt/β-catenin inhibitor (IWR-1) changed the iPSC-AETII–like phenotype to a predominantly AETI-like phenotype. We found that of induced AET1 cells, more than 90% were positive for type I markers, T1α, and caveolin-1. Acellular lung matrices were prepared from whole rat or human adult lungs treated with decellularization reagents, followed by seeding these matrices with alveolar cells derived from human iPSCs. Under appropriate culture conditions, these progenitor cells adhered to and proliferated within the 3D lung tissue scaffold and displayed markers of differentiated pulmonary epithelium.
Recurrence plots from altimetry data of some lakes in Africa
Creators: name: Sparavigna, Amelia Carolina
Publisher: name: arXiv
Year: 2014
Subjects: subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Chaotic Dynamics (nlin.CD)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: The paper shows recurrence plots obtained from time series of the level variations of four lakes in Africa (Nasser, Tana, Chad and Kainji). The data, coming from remote sensing, are provided by the United States Department of Agriculture. The recurrence plots allow a good visual comparison of the behaviours of local drainage basins.
description: Keywords: Recurrence plots, Geophysics, Chaos, Attractors, Climate
Multicriticality in Yang-Lee edge singularity
Creators: name: Lencsés, Máté
name: Miscioscia, Alessio
name: Mussardo, Giuseppe
name: Takács, Gábor
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In this paper we study the non-unitary deformations of the two-dimensional Tricritical Ising Model obtained by coupling its two spin Z2 odd operators to imaginary magnetic fields. Varying the strengths of these imaginary magnetic fields and adjusting correspondingly the coupling constants of the two spin Z2 even fields, we establish the presence of two universality classes of infrared fixed points on the critical surface. The first class corresponds to the familiar Yang-Lee edge singularity, while the second class to its tricritical version. We argue that these two universality classes are controlled by the conformal non-unitary minimal models M(2,5) and M(2,7) respectively, which is supported by considerations based on PT symmetry and the corresponding extension of Zamolodchikov's c-theorem, and also verified numerically using the truncated conformal space approach. Our results are in agreement with a previous numerical study of the lattice version of the Tricritical Ising Model [1]. We also conjecture the classes of universality corresponding to higher non-unitary multicritical points obtained by perturbing the conformal unitary models with imaginary coupling magnetic fields.
description: 34 pages
WORKFLOW AUTOMATION WITH POSTGIS TOPOLOGY
Creators: name: Jacobsen, Anders Møller
Publisher: name: Geoforum Perspektiv
Year: 2018

description: Traditionally, a process of changing district borders can be a long and cumbersome process involving several layers of political decision-making. By using PostGIS topology and database triggers the workflow can be optimised and the setup automated, ultimately presenting the end-user with a fluent and fully automatic workflow without any complicated data interactions. This moves the responsibility from the GIS department out in the organisation. This paper presents the findings of creating this setup with the case of school districts, and creates a foundation for an automated editing process to be integrated with a webGIS application.
description: Geoforum Perspektiv, Vol 15 No 28 (2016): Special issue related to the yearly conference, Kortdage
Peering into the Young Planetary System AB Pic. Atmosphere, Orbit, Obliquity & Second Planetary Candidate
Creators: name: Palma-Bifani, P.
name: Chauvin, G.
name: Bonnefoy, M.
name: Rojo, P. M.
name: Petrus, S.
name: Rodet, L.
name: Langlois, M.
name: Allard, F.
name: Charnay, B.
name: Desgrange, C.
name: Homeier, D.
name: Lagrange, A. -M.
name: Beuzit, J. -L.
name: Baudoz, P.
name: Boccaletti, A.
name: Chomez, A.
name: Delorme, P.
name: Desidera, S.
name: Feldt, M.
name: Ginski, C.
name: Gratton, R.
name: Maire, A. -L.
name: Meyer, M.
name: Samland, M.
name: Snellen, I.
name: Vigan, A.
name: Zhang, Y.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We aim to revisit the system AB Pic which has a known companion at the exoplanet/ brown-dwarf boundary. We based this study on a rich set of observations to investigate the companion's orbit and atmosphere. We composed a spectrum of AB Pic b merging archival VLT/SINFONI K-band data, with published spectra at J and H-band (SINFONI) and Lp-band (Magellan-AO), and photometric measurements (HST and Spitzer). We modeled the spectrum with ForMoSA, based on two atmospheric models: ExoREM and BT-SETTL13. We determined the orbital properties of b fitting the astrometric measurements from NaCo (2003 and 2004) and SPHERE (2015). The orbital solutions favor a semi-major axis of $\sim$190au viewed edge-on. With Exo-REM, we derive a T$_{eff}$ of 1700$\pm$50K and surface gravity of 4.5$\pm$0.3dex, consistent with previous works, and we report for the first time a C/O ratio of 0.58$\pm$0.08 ($\sim$solar). The posteriors are sensitive to the wavelength interval and the family of models used. Given the 2.1hr rotation period and our vsin(i) of $\sim$73km/s, we estimate for the first time the true obliquity to be $\sim$45 or $\sim$135deg, indicating a significant misalignment between the planet's spin and orbit orientations. Finally, a proper motion anomaly between the Hipparcos and Gaia eDR3 compared to our SPHERE detection limits and adapted radial velocity limits indicate the existence of a $\sim$6M$_{Jup}$ inner planet orbiting from 2 to 10au (40-200mas). The possible existence of an inner companion and the likely miss-alignment of the spin axis orientation strongly favor a formation path by gravitational instability or core accretion within a disk closer inside followed by dynamical interactions. Confirmation and characterization of planet c and access to a broader wavelength coverage for planet b will be essential to probe the uncertainties associated with the parameters.
description: 17 pages, 13 Figures, 6 Tables