cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: "Percutaneous CT-guided biopsy: an effective approach to pancreatic and peripancreatic pathology diagnosis"
Creators: name: Fernández Gonzalo, Adriana
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Tissue characterisation
subject: Pathology
subject: Education and training
subject: Technical aspects
subject: Diagnostic procedure
subject: Biopsy
subject: Percutaneous
subject: CT
subject: Pancreas
subject: Interventional non-vascular
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Description of main technical aspects and our experience withCT-guided biopsy of pancreatic and peripancreatic area, to study tumor and tumor-like conditions not being succesfully diagnosed with a previousendoscopic approach. Analysis of the type of...
Friedel Oscillations as a Probe of Fermionic Quasiparticles
Creators: name: Torre, Emanuele G. Dalla
name: Benjamin, David
name: He, Yang
name: Dentelski, David
name: Demler, Eugene
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: When immersed in a see of cold electrons, local impurities give rise to density modulations known as Friedel oscillations. In spite of the generality of this phenomenon, the exact shape of these modulations is usually computed only for non-interacting electrons with a quadratic dispersion relation. In actual materials, one needs to take into account several additional factors, such as (i) the details of the band structure, (ii) the lifetime of quasiparticles, (iii) in superconductors, the presence of a pairing gap. Studying how these effects influence Friedel oscillations is a viable way to access the properties of fermionic excitations in strongly-correlated materials. In this work we analyze the signatures of Friedel oscillations in STM and X-ray scattering experiments, focusing on the concrete example of cuprates superconductors. A detailed comparison with recent experiments reveals a rich interplay between local modulation of the chemical potential and of the pairing gap.
description: 18 pages, 14 figures, content updated, now including a discussion on c-axis correlations
The stability of the optical flux variation gradient for 3C120
Creators: name: Ramolla, Michael
name: Nuñez, Francisco Pozo
name: Westhues, Christian
name: Haas, Martin
name: Chini, Rolf
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: New $B$- and $V$-band monitoring in 2014 $-$ 2015 reveals that the Seyfert 1 Galaxy, 3C120, has brightened by a magnitude of $1.4$, compared to our campaign that took place in 2009 $-$ 2010. This allowed us to check for the debated luminosity and time-dependent color variations claimed for SDSS quasars. For our 3C120 data, we find that the $B/V$ flux ratio of the variable component in the bright epoch is indistinguishable from the faint one. We do not find any color variability on different timescales ranging from about $1$ to $1800$ days. We suggest that the luminosity and time-dependent color variability is an artifact caused by analyzing the data in magnitudes instead of fluxes. The flux variation gradients of both epochs yield consistent estimates of the host galaxy contribution to our 7.5" aperture. These results confirm that the optical flux variation gradient method works well for Seyfert galaxies.
description: 8 pages, 6 figures. Accepted for publication in section 4. Extragalactic astronomy of Astronomy and Astrophysics v2: Language-Editor Version
title: Fungal sinusitis with Intracranial extension----- MRI brain A helping Imaging tool
Creators: name: Arooj, Shumaila
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Infection
subject: Imaging sequences
subject: MR
subject: Neuroradiology brain

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To study the role ofof Magnetic Resonance Imaging (MRI) to detect intracranial Fungal infections especially with T2WI...
Influence of Substance Use Disorders on 2-Year HIV Care Retention in the United States
Creators: name: Williams, J.R.
name: Moore, R.D.
name: Eron, J.J.
name: Mugavero, M.J.
name: Mayer, K.H.
name: Dombrowski, J.C.
name: Donovan, D.M.
name: Rodriguez, B.
name: Mathews, C.
name: Hartzler, B.
name: Napravnik, S.
name: Geng, E.H.
name: Crane, H.M.
Publisher: name: Springer New York LLC
Year: 2018

description: Substance use disorders (SUDs) are thought to predict care discontinuity, though magnitude and substance-specific variance of effects are unclear. This report of analytic work undertaken with a multi-regional American cohort of 9153 care enrollees addresses these gaps. Care retention was computed from 24-month post-linkage clinic visit documentation, with SUD cases identified from patient-report screening instruments. Two generalized estimating equations tested binary and hierarchial SUD predictors of retention, and potential effect modification by patient age-group, sex, and care site. Findings demonstrate: (1) detrimental SUD effect, equivalent to a nine percentage-point decrease in retention, with independent effects of age-group and care site; (2) substance-specific effect of marijuana UD associated with lower retention; and (3) age-modification of each effect on care discontinuity, with SUDs serving as a risk factor among 18–29 year-olds and protective factor among 60+ year-olds. Collective findings document patient attributes as influences that place particular subgroups at-risk to discontinue care.
New Paradigms For Asteroid Formation
Creators: name: Johansen, Anders
name: Jacquet, Emmanuel
name: Cuzzi, Jeffrey N.
name: Morbidelli, Alessandro
name: Gounelle, Matthieu
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Asteroids and meteorites provide key evidence on the formation of planetesimals in the Solar System. Asteroids are traditionally thought to form in a bottom-up process by coagulation within a population of initially km-scale planetesimals. However, new models challenge this idea by demonstrating that asteroids of sizes from 100 to 1000 km can form directly from the gravitational collapse of small particles which have organised themselves in dense filaments and clusters in the turbulent gas. Particles concentrate passively between eddies down to the smallest scales of the turbulent gas flow and inside large-scale pressure bumps and vortices. The streaming instability causes particles to take an active role in the concentration, by piling up in dense filaments whose friction on the gas reduces the radial drift compared to that of isolated particles. In this chapter we review new paradigms for asteroid formation and compare critically against the observed properties of asteroids as well as constraints from meteorites. Chondrules of typical sizes from 0.1 to 1 mm are ubiquitous in primitive meteorites and likely represent the primary building blocks of asteroids. Chondrule-sized particles are nevertheless tightly coupled to the gas via friction and are therefore hard to concentrate in large amounts in the turbulent gas. We review recent progress on understanding the incorporation of chondrules into the asteroids, including layered accretion models where chondrules are accreted onto asteroids over millions of years. We highlight in the end ten unsolved questions in asteroid formation where we expect that progress will be made over the next decade.
description: Chapter to appear in the book ASTEROIDS IV, (University of Arizona Press) Space Science Series, edited by P. Michel, F. DeMeo and W. Bottke
(101996) Lucy Williams
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
New antiretroviral agent use affects prevalence of HIV drug resistance in clinical care populations
Creators: name: Brunet, L.
name: Davy-Mendez, T.
name: Eron, J.J.
name: Napravnik, S.
name: Dennis, A.M.
name: Zakharova, O.
Publisher: name: NLM (Medline)
Year: 2018

description: OBJECTIVE: To estimate the prevalence of HIV drug resistance over time and identify risk factors for multiclass resistance. DESIGN: Prospective clinical cohort of HIV-infected patients at the University of North Carolina. METHODS: Among antiretroviral therapy (ART)-experienced patients in care 2000-2016, we estimated annual prevalences of cumulative resistance, defined as at least one major mutation by drug class. Clinical data and multiple imputation were used when genotypic data were missing, and mutations were carried forward in time. We estimated resistance odds ratios comparing characteristics of patients in care in 2016. RESULTS: A total of 3682 patients contributed 23 169 person-years. Prevalence of at least one major resistance mutation, irrespective of viral suppression, peaked in 2005 with 49% (95% confidence interval 46, 52) and decreased to 38% (35, 40) in 2016. Resistance to nucleoside reverse transcriptase inhibitors, protease inhibitors, and nonnucleoside reverse transcriptase inhibitors also peaked in 2005-2007 and decreased to 28 (26, 31), 14 (12, 16), and 27% (24, 29) in 2016, respectively. In 2016, prevalence of integrase strand transfer inhibitor (INSTI) resistance was 2% (1, 3) and triple-class resistance 10% (9, 12). Over the study period, cumulative resistance was frequent among patients with detectable viremia, but uncommon among patients initiating ART post-2007. Among 1553 patients in care in 2016, ART initiation at an older age, with an INSTI, and with higher CD4 cell counts were associated with resistance to fewer or no classes. CONCLUSION: Prevalence of resistance to older ART classes has decreased in the last 10 years in this clinical cohort, whereas INSTI resistance has increased but remained very low. Patients with viremia continue to have a high burden of resistance even if they initiated ART recently.
title: MRI evaluation of rectal anatomy
Creators: name: Schirru, Federica
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Colon
subject: Anatomy
subject: Oncology
subject: MR
subject: Education
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: to know MRI indication and techniques in rectal study; to know the normal anatomy of male and female pelvis by MRI; to evaluate and stage rectal...
Characterization of the haemagglutinin properties of the H5N1 avian influenza virus that caused human infections in Cambodia
Creators: name: Chang, Pengxiang
name: Yang, Jiayun
name: Karunarathna, Thusitha K.
name: Qureshi, Mehnaz
name: Sadeyen, Jean-Remy
name: Iqbal, Munir
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Characterization of the haemagglutinin properties of the H5N1 avian influenza virus that caused human infections in Cambodia
Highly Efficient Midinfrared On-Chip Electrical Generation of Graphene Plasmons by Inelastic Electron Tunneling Excitation
Creators: name: Ooi, Kelvin J. A.
name: Chu, Hong Son
name: Hsieh, Chang Yu
name: Tan, Dawn T. H.
name: Ang, Lay Kee
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Inelastic electron tunneling provides a low-energy pathway for the excitation of surface plasmons and light emission. We theoretically investigate tunnel junctions based on metals and graphene. We show that graphene is potentially a highly efficient material for tunneling excitation of plasmons because of its narrow plasmon linewidths, strong emission, and large tunability in the midinfrared wavelength regime. Compared to gold and silver, the enhancement can be up to 10 times for similar wavelengths and up to 5 orders at their respective plasmon operating wavelengths. Tunneling excitation of graphene plasmons promises an efficient technology for on-chip electrical generation and manipulation of plasmons for graphene-based optoelectronics and nanophotonic integrated circuits.
description: 12 pages, 7 figures
(101998) Julia Lemon
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Malignant causes of biliary dilatation: radiologic evaluation and differential diagnosis
Creators: name: Gallego Ferrero, Paula
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Biliary Tract / Gallbladder
subject: Oncology
subject: CT
subject: MR
subject: Ultrasound
subject: Diagnostic procedure
subject: Neoplasia
subject: Dilatation

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To revise the anatomy of the common bile duct, pancreas and duodenum region. To analyze the neoplastic lesions that can appear in this particular location and their radiological...
HIV Drug Resistance in Adults Receiving Early vs. Delayed Antiretroviral Therapy: HPTN 052
Creators: name: Gallant, J.E.
name: Makhema, J.
name: Panchia, R.
name: Morgado, M.G.
name: Wallis, C.
name: Badal-Faesen, S.
name: Chariyalertsak, S.
name: Wilson, E.A.
name: Eron, J.J.
name: Hakim, J.G.
name: Kumarasamy, N.
name: Saravanan, S.
name: Hovind, L.
name: Hosseinipour, M.C.
name: Kumwenda, J.
name: Godbole, S.V.
name: Pilotto, J.H.
name: Fogel, J.M.
name: Papathanasopoulos, M.A.
name: Palumbo, P.J.
name: Gamble, T.
name: Hart, S.
name: Grinsztejn, B.
name: Tripathy, S.
name: Cohen, M.S.
name: Piwowar-Manning, E.
name: Chen, Y.Q.
name: Eshleman, S.H.
name: McCauley, M.
name: Hudelson, S.E.
name: Akelo, V.
name: Santos, B.R.
Publisher: name: Lippincott Williams and Wilkins
Year: 2018

description: Introduction: We evaluated HIV drug resistance in adults who received early vs. delayed antiretroviral therapy (ART) in a multinational trial [HIV Prevention Trials Network (HPTN) 052, enrollment 2005-2010]. In HPTN 052, 1763 index participants were randomized to start ART at a CD4 cell count of 350-550 cells/mm 3 (early ART arm) or <250 cells/mm 3 (delayed ART arm). In May 2011, interim study results showed benefit of early ART, and all participants were offered ART regardless of CD4 cell count; the study ended in 2015. Methods: Virologic failure was defined as 2 consecutive viral loads >1000 copies/mL >24 weeks after ART initiation. Drug resistance testing was performed for pretreatment (baseline) and failure samples from participants with virologic failure. Results: HIV genotyping results were obtained for 211/249 participants (128 early ART arm and 83 delayed ART arm) with virologic failure. Drug resistance was detected in 4.7% of participants at baseline; 35.5% had new resistance at failure. In univariate analysis, the frequency of new resistance at failure was lower among participants in the early ART arm (compared with delayed ART arm, P = 0.06; compared with delayed ART arm with ART initiation before May 2011, P = 0.032). In multivariate analysis, higher baseline viral load (P = 0.0008) and ART regimen (efavirenz/lamivudine/zidovudine compared with other regimens, P = 0.024) were independently associated with higher risk of new resistance at failure. Conclusions: In HPTN 052, the frequency of new drug resistance at virologic failure was lower in adults with early ART initiation. The main factor associated with reduced drug resistance with early ART was lower baseline viral load.
(101994) Julia Jessie Williams
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Acute HIV infection and CD4/CD8 ratio normalization after antiretroviral therapy initiation
Creators: name: Eron, J.J.
name: Hicks, C.B.
name: Napravnik, S.
name: Kuruc, J.
name: McGee, K.S.
name: Zakharova, O.
name: Gay, C.
name: Davy-Mendez, T.
Publisher: name: Lippincott Williams and Wilkins
Year: 2018

description: Background:We estimated the effect of initiating virologically suppressive antiretroviral therapy (ART) during acute HIV infection versus chronic HIV infection (AHI vs. CHI) on CD4/CD8 ratio normalization.Setting:A prospective clinical cohort study.Methods:We included patients initiating ART with AHI and CHI between 2000 and 2015 and compared time from ART initiation to the first normal CD4/CD8 ratio (defined as CD4/CD8 ≥1) using Kaplan-Meier curves and multivariable Cox proportional hazards models. Patient time was censored at virologic failure, lost to follow-up, or death. We also characterized CD4, CD8, and CD4/CD8 trajectories over the first 3 years of ART.Results:The 1198 patients were 27% female and 60% African American, with a median age of 37 years (interquartile range 28-47) at ART initiation. The 83 AHI patients were more likely male, younger, and of white race, than CHI patients. After 2 years of suppressive ART, 70% of AHI patients achieved a normal CD4/CD8 ratio, compared to 6%-38% of CHI patients, with greater likelihood of normalization at higher baseline CD4 counts. Time to normalization was shortest among AHI patients, followed by CHI patients with higher baseline CD4. The adjusted hazard ratio for time to normalization for AHI patients compared to CHI patients with baseline CD4 >350 was 4.33 (95% CI: 3.16 to 5.93). Higher baseline CD4/CD8 ratio was also associated with time to normalization (adjusted hazard ratio 1.54; 1.46, 1.63, per 0.1 increase in ratio).Conclusions:Initiating ART during AHI at higher baseline CD4 cell counts and CD4/CD8 ratios was associated with shorter time to CD4/CD8 ratio normalization.
title: To assess the role of pelvic magnetic resonance imaging (MRI) in the evaluation of patients with cervical cancer.
Creators: name: Crivceanschi, Maxim
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Outcomes
subject: Neoplasia
subject: Metastases
subject: Staging
subject: MR
subject: Oncology
subject: Genital / Reproductive system female

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To assess the role of pelvic magnetic resonance imaging (MRI) in the evaluation of patients with cervical...
Leveraging phylogenetics to understand HIV transmission and partner notification networks
Creators: name: Pasquale, D.K.
name: Doherty, I.A.
name: Leone, P.A.
name: Ledford, S.L.
name: Sampson, L.A.
name: Sebastian, J.
name: Hué, S.
name: Miller, W.C.
name: Dennis, A.M.
name: Eron, J.J.
Publisher: name: Lippincott Williams and Wilkins
Year: 2018

description: Background: Partner notification is an important component of public health test and treat interventions. To enhance this essential function, we assessed the potential for molecular methods to supplement routine partner notification and corroborate HIV networks. Methods: All persons diagnosed with HIV infection in Wake County, NC, during 2012-2013 and their disclosed sexual partners were included in a sexual network. A data set containing HIV-1 pol sequences collected in NC during 1997-2014 from 15,246 persons was matched to HIV-positive persons in the network and used to identify putative transmission clusters. Both networks were compared. Results: The partner notification network comprised 280 index cases and 383 sexual partners and high-risk social contacts (n = 131 HIVpositive). Of the 411 HIV-positive persons in the partner notification network, 181 (44%) did not match to a HIV sequence, 61 (15%) had sequences but were not identified in a transmission cluster, and 169 (41%) were identified in a transmission cluster. More than half (59%) of transmission clusters bridged sexual network partnerships that were not recognized in the partner notification; most of these clusters were dominated by men who have sex with men. Conclusions: Partner notification and HIV sequence analysis provide complementary representations of the existent partnerships underlying the HIV transmission network. The partner notification network components were bridged by transmission clusters, particularly among components dominated by men who have sex with men. Supplementing the partner notification network with phylogenetic data highlighted avenues for intervention.
An investigation on wire-EDM of a biodegradable ZE41A magnesium alloy
Creators: name: Krishna, D.V.
name: Rao, N.M. Prakash
name: Srivatsan, T.S.
name: Sankar, M.R.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Space Science
Medicine
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Science Policy

description: The ZE41A magnesium alloy is a propitious material for biomedical applications since it offers a concoction of good biocompatible and biodegradable properties. The wire cut electrical discharge machining (WEDM) is used for machining magnesium alloys primarily because it can produce products with good dimensional accurateness when compared one-on-one with the traditional machining methods. The kerf width and surface roughness are pivotal response factors heavily impacted by WEDM machining parameters. The current research uses WEDM to machine the biodegradable magnesium alloy ZE41A. The preliminary studies were conducted to identify the range of machining parameters by carefully considering kerf width and surface roughness as the responses. The central composite rotatable design determines the optimal experiments to evaluate the response parameters. Based on a comparative analysis, it is clinched that the flushing pressure is a dominant parameter on both kerf width and surface roughness. The experimental data is further processed to develop an empirical or experimental model for both responses as a function of machining parameters. The corroboration experiments were conducted to test the predictability of the experimental model. The accurateness of the empirical model was examined with the experimental results, and the outcomes were found to be satisfactory.
title: Magnetic resonance imaging in the preoperative assessment of Mayer-Rokitansky-Kuster-Hauser syndrome
Creators: name: Rotaru, Natalia
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Genital / Reproductive system female
subject: Pelvis
subject: MR
subject: Diagnostic procedure
subject: Congenital

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To define the role ofmagneticresonance imaging (MRI) in diagnosing and evaluating patients withMayer-Rokitansky-Kuster-Hauser (MRKH)...
Generalized Contact Bundles
Creators: name: Vitagliano, Luca
name: Wade, Aïssa
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: Mathematical Physics (math-ph)
subject: Symplectic Geometry (math.SG)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 53D18 (Primary), 53D10, 53D15, 53D17, 53D35, 22A22

description: In this Note, we propose a line bundle approach to odd-dimensional analogues of generalized complex structures. This new approach has three main advantages: (1) it encompasses all existing ones; (2) it elucidates the geometric meaning of the integrability condition for generalized contact structures; (3) in light of new results on multiplicative forms and Spencer operators, it allows a simple interpretation of the defining equations of a generalized contact structure in terms of Lie algebroids and Lie groupoids.
description: Short Note: 8 pages. Minor revisions. Published in C. R. Math. Comments welcome!
Brain neurotransmitter transporter/receptor genomics and efavirenz central nervous system adverse events
Creators: name: Acosta, E.P.
name: Haas, D.W.
name: Eron, J.J.
name: Sax, P.E.
name: Verma, S.S.
name: Daar, E.S.
name: Morse, G.D.
name: Gulick, R.M.
name: Ritchie, M.D.
name: Bradford, Y.
name: Verma, A.
name: Riddler, S.A.
Publisher: name: Lippincott Williams and Wilkins
Year: 2018

description: Objective We characterized associations between central nervous system (CNS) adverse events and brain neurotransmitter transporter/receptor genomics among participants randomized to efavirenz-containing regimens in AIDS Clinical Trials Group studies in the USA. Participants and methods Four clinical trials randomly assigned treatment-naive participants to efavirenzcontaining regimens. Genome-wide genotype and PrediXcan were used to infer gene expression levels in tissues including 10 brain regions. Multivariable regression models stratified by race/ethnicity were adjusted for CYP2B6/CYP2A6 genotypes that predict plasma efavirenz exposure, age, and sex. Combined analyses also adjusted for genetic ancestry. Results Analyses included 167 cases with grade 2 or greater efavirenz-consistent CNS adverse events within 48 weeks of study entry, and 653 efavirenz-tolerant controls. CYP2B6/CYP2A6 genotype level was independently associated with CNS adverse events (odds ratio: 1.07; P=0.044). Predicted expression of six genes postulated to mediate efavirenz CNS side effects (SLC6A2, SLC6A3, PGR, HTR2A, HTR2B, HTR6) were not associated with CNS adverse events after correcting for multiple testing, the lowest P value being for PGR in hippocampus (P=0.012), nor were polymorphisms in these genes or AR and HTR2C, the lowest P value being for rs12393326 in HTR2C (P=6.7 × 10-4). As a positive control, baseline plasma bilirubin concentration was associated with predicted liver UGT1A1 expression level (P=1.9 × 10-27). Conclusion Efavirenz-related CNS adverse events were not associated with predicted neurotransmitter transporter/receptor gene expression levels in brain or with polymorphisms in these genes. Variable susceptibility to efavirenz-related CNS adverse events may not be explained by brain neurotransmitter transporter/receptor genomics.
Cancer risk in HIV patients with incomplete viral suppression after initiation of antiretroviral therapy
Creators: name: Dittmer, D.P.
name: Althoff, K.N.
name: Richardson, D.B.
name: Cole, S.R.
name: Lee, J.S.
name: AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS)
name: Mathews, C.
name: Achenbach, C.J.
name: Moore, R.D.
name: Miller, W.C.
name: Eron, J.J., Jr.
Publisher: name: Public Library of Science
Year: 2018

description: Background Cancer causes significant morbidity and mortality among HIV patients in the US due to extended life expectancy with access to effective antiretroviral therapy. Low, detectable HIV RNA has been studied as a risk factor for adverse health outcomes, but its clinical impact on cancer risk remains unclear. The objective of this study was to determine whether HIV RNA <1,000 copies/mL six months after starting therapy was associated with 10-year first cancer risk. Methods We followed 7,515 HIV therapy initiators from a US-based multicenter clinical cohort from 1998 to 2014. We used nonparametric multiple imputation to account for viral loads that fell below assay detection limits, and categorized viral loads six months after therapy initiation into four groups: <20, 20–199, 200–999, and >999 copies/mL. We calculated estimates of the cumulative incidence of cancer diagnosis, accounting for death as a competing event. Inverse probability of exposure and censoring weights were used to control for confounding and differential loss to follow up, respectively. Results Crude 10-year first cancer risk in the study sample was 7.03% (95% CI: 6.08%, 7.98%), with the highest risk observed among patients with viral loads between 200 and 999 copies/mL six months after ART initiation (10.7%). After controlling for baseline confounders, 10-year first cancer risk was 6.90% (95% CI: 5.69%, 8.12%), and was similar across viral load categories. Conclusion Overall risk of first cancer was not associated with incomplete viral suppression; however, cancer remains a significant threat to HIV patients after treatment initiation. As more HIV patients gain access to treatment in the current “treat all” era, occurrences of incomplete viral suppression will be observed more frequently in clinical practice, which supports continued study of the role of low-level HIV RNA on cancer development.
Aqua jet integrated fiber laser machining of quaternary NiTiCuZr alloy
Creators: name: Balasubramaniyan, C.
name: Rajkumar, K.
name: Santosh, S.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Space Science
Medicine
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Astronomical and Space Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Low thermal diffusivity of NiTi-based smart alloy results in concentrated heat accumulation during laser beam machining which rises to adverse thermal effects like heat-affected zones, residual stresses, and alterations in microstructure of shape memory alloy (SMA) system. The addition of Cu and Zr can reduce the thermal hysteresis in the phase transformation of NiTi SMAs. Minimizing thermal hysteresis is desirable in SMA applications where precise control of the phase transformation temperatures is required, such as in actuators, sensors, and medical devices. Therefore, aqua jet integrated laser (AJ-FLBM) machining is a suitable choice for smart materials that need to be machined with high precision and low heat affected zone. In this current research, the NiTiCuZr SMA is machined using AJ-FLBM to investigate the effects of process variables on surface characteristics measured using RSM-BBD approach. The surface quality was enhanced by 68.93% with a gradual decrease in laser power (P), cutting speed (CS), and an increase in frequency (F). Aqua jet integrated FLBM technique may reduce heat affected zone due to the removal of heat in areas near the cutting location. This was confirmed by the DSC test which reveals that optimal machining inputs do not alter shape memory properties.
title: Advances in aortic arch aneurysm endovascular treatment with branched endograft: our experience with Bolton Medical Double-Branch devices.
Creators: name: Ferrari, Antonio
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Arteries / Aorta
subject: Interventional vascular
subject: Vascular
subject: Catheter arteriography
subject: CT-Angiography
subject: Arterial access
subject: Surgery
subject: Education
subject: Aneurysms

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this work is to illustrate the recent advances in the endovascular treatment of aortic arch disease with the use of branched...
(101990) Mary Isabella Williams
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Driven impurity in an ultracold 1D Bose gas with intermediate interaction strength
Creators: name: Castelnovo, Claudio
name: Caux, Jean-Sébastien
name: Simon, Steven H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study a single impurity driven by a constant force through a 1D Bose gas using a Lieb-Liniger based approach. Our calculaton is exact in the interaction amongst the particles in the Bose gas, and is perturbative in the interaction between the gas and the impurity. In contrast to previous studies of this problem, we are able to handle arbitrary interaction strength for the Bose gas. We find very good agreement with recent experiments [Phys. Rev. Lett. 103, 150601 (2009)].
description: (7 pages, 5 figures)
title: Implementation of diagnostic imaging quality assurance program in the Republic of Moldova: aiming towards EU standards and legislation adjustments
Creators: name: Rotaru, Natalia
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Management
subject: CT
subject: MR
subject: Mammography
subject: Efficacy studies
subject: Outcomes analysis
subject: Education
subject: Quality assurance

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To emphasize the role of continuous quality improvement and quality management in improving the quality of health...
(101991) Clara Williams
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Escola Municipal Melo Viana, São Lourenço, MG
Creators: name: Rodrigues Dias, Marco Aurélio
Publisher: name: figshare
Year: 2023
Subjects: Creative arts, media and communication curriculum and pedagogy
Early childhood education
Continuing and community education
Teacher education and professional development of educators

description: O objetivo deste trabalho é relatar minha experiência de estágio (2022) no Ensino Fundamental I, 2º Período, na Escola Municipal Melo Viana, em São Lourenço, Minas Gerais, contextualizando o fato de que o plano de aula é coletivo, é para todos os alunos da classe, mas a compreensão dos conteúdos e tarefas é individual e diferenciada, uns aprendem mais, outros menos, ressaltando-se que a desatenção ou distração do aluno durante a apresentação do plano de aula é um dos complicadores da aprendizagem. A atenção contínua do professor sobre a possível desatenção do aluno, bem como a intervenção necessária, é uma ferramenta importante e indispensável no processo ensino-aprendizagem.
Prevalence and transmission dynamics of HIV-1 transmitted drug resistance in a southeastern cohort
Creators: name: Okeke, N.L.
name: Levintow, S.N.
name: Virkud, A.
name: Mkumba, L.
name: Miller, W.C.
name: Sebastian, J.
name: Dennis, A.M.
name: Hué, S.
name: Eron, J.J.
name: Napravnik, S.
Publisher: name: Oxford University Press
Year: 2018

description: Background. Transmitted drug resistance (TDR) compromises clinical management and outcomes. Transmitted drug resistance surveillance and identification of growing transmission clusters are needed in the Southeast, the epicenter of the US HIV epidemic. Our study investigated prevalence and transmission dynamics in North Carolina. Methods. We analyzed surveillance drug resistance mutations (SDRMs) using partial pol sequences from patients presenting to 2 large HIV outpatient clinics from 1997 to 2014. Transmitted drug resistance prevalence was defined as =1 SDRMs among antiretroviral therapy (ART)-naïve patients. Binomial regression was used to characterize prevalence by calendar year, drug class, and demographic and clinical factors. We assessed the transmission networks of patients with TDR with maximum likelihood trees and Bayesian methods including background pol sequences (n = 15 246). Results. Among 1658 patients with pretherapy resistance testing, =1 SDRMs was identified in 199 patients, with an aggregate TDR prevalence of 12% (95% confidence interval, 10% to 14%) increasing over time (P =.02). Resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs; 8%) was common, followed by nucleoside reverse transcriptase inhibitors (4%) and protease inhibitors (2%). Factors associated with TDR were being a man reporting sex with men, white race, young age, higher CD4 cell count, and being a member of a transmission cluster. Transmitted drug resistance was identified in 106 clusters ranging from 2 to 26 members. Cluster resistance was primarily NNRTI and dominated by ART-naïve patients or those with unknown ART initiation. Conclusions. Moderate TDR prevalence persists in North Carolina, predominantly driven by NNRTI resistance. Most TDR cases were identified in transmission clusters, signifying multiple local transmission networks and TDR circulation among ARTnaïve persons. Transmitted drug resistance surveillance can detect transmission networks and identify patients for enhanced services to promote early treatment.
Exploration and Practice of Improving Programming Ability for the Undergraduates Majoring in Computer Science
Creators: name: Yuan, Guowu
name: Liu, Shicai
Publisher: name: arXiv
Year: 2025
Subjects: subject: Computers and Society (cs.CY)
subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Programming ability is one of the most important abilities for the undergraduates majoring in computer science. Taking Yunnan University as an example, the necessity and importance of improving the ability of programming is analyzed in this paper. The exploration and practice of improving students' ability of programming are discussed from four aspects: arrangement and reform of programming curriculums, construction of online programming practice innovation platform, certification of programming ability and organization of programming competitions. These reforms have achieved good results in recent years, which can provide reference for the practical teaching reform of computer specialty in relevant universities.
description: 10 pages, 5 figures
title: The Advantages of Digital Radiology in Emergency Situations
Creators: name: Kolosova, Elena
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Image registration
subject: Foreign bodies
subject: Surgery
subject: Computer Applications-Detection, diagnosis
subject: Digital radiography
subject: Trauma
subject: Emergency

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: From 25.04.2015 to 15.10.2015 in Avdeevka town of Donetsk region active hostilities have been ongoing that resulted in significant increase of patients at local hospital. In the beginning of 2015 average number of radiological examinations per month...
Randomized clinical trial to assess the impact of the broadly neutralizing HIV-1 monoclonal antibody VRC01 on HIV-1 persistence in individuals on effective ART
Creators: name: Hurley, C.
name: AIDS Clinical Trials Group A5342 Protocol Team
name: Ritz, J.
name: Storey, S.
name: Gottesman, J.
name: Sbrolla, A.
name: Macatangay, B.J.C.
name: Kessels, L.
name: Arduino, R.C.
name: Acosta, Ed.
name: Perelson, A.
name: Ray, G.
name: Eron, J.J.
name: Ledgerwood, J.
name: Baer, J.
name: Zheng, L.
name: Lambert, N.
name: Kudumu, M.
name: Koup, R.A.
name: Campbell, D.
name: Tipton, M.
name: Bunce, C.A.
name: Epperson, K.
name: Villamil, A.E.
name: Sise, T.
name: Casazza, J.
name: Jennings, C.
name: Dunaway, S.
name: Tressler, R.
name: Nair, A.
name: Leonard, M.
name: Cyktor, J.C.
name: Bailer, R.T.
name: Hite, M.
name: Howard, J.
name: Muttera, L.
name: Clark, J.
name: Weinman, R.
name: Mellors, J.W.
name: Durand, C.M.
name: Koletar, S.L.
name: Flynn, T.
name: Benns, A.
name: Keefer, M.C.
name: Berzins, B.
name: Currin, D.
name: Riddler, S.A.
name: Benson, C.
name: Kittelson, P.
name: Spitz, T.
name: Wiggins, I.
name: Onesi, S.
Publisher: name: Oxford University Press
Year: 2018

description: Background. Broadly neutralizing monoclonal antibodies (bnMAbs) may promote clearance of HIV-1-expressing cells through antibody-dependent cell-mediated cytotoxicity. We evaluated the effect of the CD4-binding site bnMAb, VRC01, on measures of HIV-1 persistence in chronically infected individuals. Methods. A5342 was a phase 1, randomized, double-blind, placebo-controlled, parallel-arm study. Participants on effective antiretroviral therapy (ART) were randomized to receive 2 infusions of VRC01 (40 mg/kg) at entry and week 3, and 2 infusions of placebo (saline) at weeks 6 and 9; or 2 infusions of placebo at entry and week 3, and 2 infusions of VRC01 at weeks 6 and 9. Results. Infusion of VRC01 was safe and well tolerated. The median fold-change in the cell-associated HIV-1 RNA/DNA ratio from baseline to week 6 was 1.12 and 0.83 for the VRC01 and placebo arms, respectively, with no significant difference between arms (P = .16). There were no significant differences in the proportions with residual plasma viremia ≥1 copies/mL or in phorbol 12-myristate 13-acetate/ionomycin-induced virus production from CD4+ T cells between arms (both P > .05). Conclusions. In individuals with chronic HIV-1 infection on ART, VRC01 infusions were safe and well tolerated but did not affect plasma viremia, cellular HIV-1 RNA/DNA levels, or stimulated virus production from CD4+ T cells.
Regularization of ultraviolet divergence for a particle interacting with a scalar quantum field
Creators: name: Skoromnik, O. D.
name: Feranchuk, I. D.
name: Lu, D. V.
name: Keitel, C. H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: When a nonrelativistic particle interacts with a scalar quantum field, the standard perturbation theory leads to a dependence of the energy of its ground state on an undefined parameter---"momentum cutoff"---due to the ultraviolet divergence. We show that the use of nonasymptotic states of the system results in a calculation scheme in which all observable quantities remain finite and continuously depend on the coupling constant without any additional parameters. It is furthermore demonstrated that the divergence of traditional perturbation series is caused by the energy being a function with a logarithmic singularity for small values of the coupling constant.
description: 30 pages, 3 figures
(101992) Agnes Charlotte Williams
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Six years of fMRI and MRS phantom data in a 3T clinical scanner: Quality Assurance and Stability
Creators: name: Alfayate Sáez, Eva
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Quality assurance
subject: Technical aspects
subject: Physics
subject: MR-Spectroscopy
subject: MR-Functional imaging
subject: MR
subject: Radiographers
subject: Neuroradiology brain
subject: MR physics

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: A previous study evaluating the quality assurance (QA) and stability of functional MRI (fMRI) and spectroscopy (MRS) data acquired from a phantom (period of 12 months) found no statistical correlation between the registered variables and the quality...