cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2 of Pharmacopeial quality of artemether–lumefantrine anti-malarial agents in Uganda
Creators: name: Ocan, Moses
name: Nakalembe, Loyce
name: Otike, Caroline
name: Omali, Denis
name: Buzibye, Allan
name: Nsobya, Sam
Publisher: name: figshare
Year: 2023
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Results of lumefantrine assay content.
title: Signal transduction in photoreceptor histidine kinases
Creators: name: Möglich, Andreas
Publisher: name: University of Bayreuth
Year: 2019
Subjects: subject: allostery, bacterial phytochrome
subject: coiled coil
subject: light-oxygen-voltage
subject: sensor histidine kinase
subject: sensory photoreceptor
subject: sensory rhodopsin
subject: signal transduction
subject: two-component system
subject: 570

description: Abstract Two-component systems (TCS) constitute the predominant means by which prokaryotes read out and adapt to their environment. Canonical TCSs comprise a sensor histidine kinase (SHK), usually a transmembrane receptor, and a response regulator (RR). In signal-dependent manner, the SHK autophosphorylates and in turn transfers the phosphoryl group to the RR which then elicits downstream responses, often in form of altered gene expression. SHKs also catalyze the hydrolysis of the phospho-RR, hence, tightly adjusting the overall degree of RR phosphorylation. Photoreceptor histidine kinases are a subset of mostly soluble, cytosolic SHKs that sense light in the near-ultraviolet to near-infrared spectral range. Owing to their experimental tractability, photoreceptor histidine kinases serve as paradigms and provide unusually detailed molecular insight into signal detection, decoding, and regulation of SHK activity. The synthesis of recent results on receptors with light-oxygen-voltage, bacteriophytochrome and microbial rhodopsin sensor units identifies recurring, joint signaling strategies. Light signals are initially absorbed by the sensor module and converted into subtle rearrangements of α helices, mostly through pivoting and rotation. These conformational transitions propagate through parallel coiled-coil linkers to the effector unit as changes in left-handed superhelical winding. Within the effector, subtle conformations are triggered that modulate the solvent accessibility of residues engaged in the kinase and phosphatase activities. Taken together, a consistent view of the entire trajectory from signal detection to regulation of output emerges. The underlying allosteric mechanisms could widely apply to TCS signaling in general.
The lamin A/C Ig-fold undergoes cell density-dependent changes that alter epitope binding
Creators: name: Wallace, Melanie
name: Fedorchak, Gregory R.
name: Agrawal, Richa
name: Gilbert, Rachel M.
name: Patel, Jineet
name: Park, Sangwoo
name: Paszek, Matthew
name: Lammerding, Jan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Lamins A/C are nuclear intermediate filament proteins that are involved in diverse cellular mechanical and biochemical functions. Here, we report that recognition of Lamins A/C by a commonly used antibody (JOL-2) that binds the Lamin A/C Ig-fold and other antibodies targeting similar epitopes is highly dependent on cell density, even though Lamin A/Clevels do not change. We propose that the effect is caused by partial unfolding or masking of the C’E and/or EF loops of the Ig-fold in response to cell spreading. Surprisingly, JOL-2 antibody labeling was insensitive to disruption of cytoskeletal filaments or the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex. Furthermore, neither nuclear stiffness nor nucleo-cytoskeletal force transmission changed with cell density. These findings are important for the interpretation of immunofluorescence data for Lamin A/C and also raise the intriguing prospect that the conformational changes may play a role in Lamin A/C mediated cellular function.
Cell division in Echerichia coli : the involvement of the peptidoglycan
Creators: name: Groves, David John
Publisher: name: University of British Columbia
Year: 2011

description: The role of the cell envelope in cell division has been examined using mutants of Escherichia coli which are temperature-sensitive in the process of cell division. These mutants grow normally at 30 C but exhibit morphological changes at 42 C. Two assays for peptidoglycan-specific autolytic enzymes have been developed. One depends on the prevention of synthesis of autolytic enzymes using chloramphenicol, while the autolytic capacity is determined by observing the rate of cell lysis in the presence of low levels of ampicillin. The second assay is based on the in vitro release of specific radioactive fragments from peptidoglycan previously labelled with radioactive diaminopimelic acid. The majority of cells in an exponential population of E. coli B/r/l are not lysed by penicillin if chloramphenicol is added. However, larger cells are particularly susceptible to lysis. Three types of lysis have been defined by observing rates of lysis of synchronous cultures at different ages and at different growth rates: (A) lysis associated with cross-wall formation during cell division; (B) lysis associated with initiation and segregation of the replication of DNA; and (C) lysis associated with general expansion of the cell wall. Filamentous mutants of E. coli which segregate DNA exhibit lysis in excess of type C while filaments formed by inhibition of DNA synthesis exhibit lysis only of type C. The autolytic enzymes of E. coli appear to be tightly bound to localized areas of the cell envelope as determined by the in vitro assay. Qualitative differences between the autolytic activities of normal cells and of filaments formed by inhibition of DNA synthesis are described.
Supplementary document for Ballistic Metamaterials. - 4901333.pdf
Creators: name: Li, Kun
name: Simmons, Evan
name: Briggs, Andrew
name: Bank, Seth
name: Wasserman, Dan
name: Podolskiy, Viktor
name: Narimanov, Evgenii
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Supplemenrary document
Direct optical observations of surface thermal motions at sub-shot noise levels
Creators: name: Mitsui, Takahisa
name: Aoki, Kenichiro
Publisher: name: arXiv
Year: 2009
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Biological Physics (physics.bio-ph)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: We measure spectral properties of surface thermal fluctuations of liquids, solids, complex fluids and biological matter using light scattering methods. The random thermal fluctuations are delineated from random noise at sub-shot noise levels. The principle behind this extraction, which is quite general and is not limited to surface measurements, is explained. An optical lever is used to measure the spectrum of fluctuations in the inclinations of surfaces down to $\sim 10^{-17}\rm rad^2/Hz$ at $1\sim10 μ$W optical intensity, corresponding to $\sim 10^{-29} \rm m^2/\rm Hz$ in the vertical displacement, in the frequency range $1{\rm}\rm kHz\sim10 MHz$. The dynamical evolution of the surface properties is also investigated. The measurement requires only a short amount of time and is essentially passive, so that it can be applied to a wide variety of surfaces.
description: 5pp, 5 figures
Regionen zukunftsfähig machen : Identifikation als Baustein zur nachhaltigen Entwicklung
Creators: name: Kempa, Daniela
name: Krätzig, Sebastian
name: Warner, Barbara
Publisher: name: Hannover : Gottfried Wilhelm Leibniz Universität Hannover, Institut für Umweltplanung
Year: 2020
Subjects: subject: Identifikation
subject: nachhaltige Entwicklung
subject: Region
subject: Zukunftsperspektiven
subject: Regionalentwicklung
subject: Dewey Decimal Classification::700 | Künste, Bildende Kunst allgemein::710 | Landschaftsgestaltung, Raumplanung

description: Die Leibniz Universität Hannover (LUH) und die ARL – Akademie für Raumentwicklung in der Leibniz-Gemeinschaft haben in einem einjährigen "Zukunftsdiskurs“ die Themen Regionalisierung und raumbezogene Identitäten stärker zusammengebracht. Die Verknüpfung dieser beiden Themen hat bereits in Vorgängerprojekten (bspw. REGIOBRANDING1) gezeigt, dass daraus innovative Ansätze für die künftige Ausrichtung von Regionen entstehen können. Mit dem Zukunftsdiskurs, der vom Niedersächsischen Ministerium für Wissenschaft und Kultur gefördert wurde, konnte die Bedeutung raumbezogener Identitäten für regionale Entwicklungsprozesse noch stärker herausgearbeitet werden. Hierfür wurde mit dem Forschungszentrum TRUST der Leibniz Universität Hannover kooperiert, das sich mit Veränderungsprozessen in städtischen und ländlichen Räumen, deren Treibern und den Auswirkungen für Mensch und Umwelt beschäftigt. Mit dieser Broschüre geben wir einen Überblick über die Erkenntnisse des Zukunftsdiskurses und formulieren Anregungen sowie praktische Hinweise zur Einbindung raumbezogener Identitäten in regionale Entwicklungsprozesse. Anhand von Beispielen aus zwei Regionen veranschaulichen wir, wie eine Umsetzung aussehen kann.
Comparative evaluation of the SPLOM and PCPM - Supplementary
Creators: name: Garner, Hugh
Publisher: name: figshare
Year: 2022
Subjects: subject: 80703 Human Information Behaviour
subject: FOS: Media and communications

description: Supplementary material for 'Comparative evaluation of the Scatter Plot Matrix and Parallel Coordinates Plot Matrix' (H.Garner and S. Johansson Fernstad)
The effect of supply chain position on zero-deforestation commitments: evidence from the cocoa industry
Creators: name: Carodenuto, Sophia
name: Buluran, Marcelyn
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Plant Biology
subject: Computational Biology

description: Global agrifood companies’ sustainability strategies have evolved to increasingly rely on self-set voluntary commitments to address the persistent social and environmental challenges embedded in commodity supply chains. While state actors continue to guide sustainability efforts within their jurisdictions, the onus is increasingly placed on corporations who pronounce their own measures to eliminate deforestation and other unethical practices associated with their business operations. In this contribution, we analyze the publicly available action plans from all corporate signatories to the Cocoa and Forests Initiative (CFI), a novel zero-deforestation commitment that focuses mainly on the world’s top cocoa producers: Côte d’Ivoire and Ghana. We construct a CFI index to systematically compare company pledges and uncover any relationships between the strength or quality of a company’s CFI action plan and key company characteristics. We find that, contrary to what the literature would suggest, the consumer-facing and high brand value firms are pronouncing less stringent zero-deforestation commitments as compared to their upstream partners. We also find key gaps in the CFI, including the lack of clarity surrounding definitions and timelines, neglect of indirect supply chains, and unclear geospatial precision.
The farnesyl transferase inhibitor (FTI) lonafarnib improves nuclear morphology in ZMPSTE24-deficient fibroblasts from patients with the progeroid disorder MAD-B
Creators: name: Odinammadu, Kamsi O.
name: Shilagardi, Khurts
name: Tuminelli, Kelsey
name: Judge, Daniel P.
name: Gordon, Leslie B.
name: Michaelis, Susan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: Computational Biology

description: Several related progeroid disorders are caused by defective post-translational processing of prelamin A, the precursor of the nuclear scaffold protein lamin A, encoded by LMNA. Prelamin A undergoes farnesylation and additional modifications at its C-terminus. Subsequently, the farnesylated C-terminal segment is cleaved off by the zinc metalloprotease ZMPSTE24. The premature aging disorder Hutchinson Gilford progeria syndrome (HGPS) and a related progeroid disease, mandibuloacral dysplasia (MAD-B), are caused by mutations in LMNA and ZMPSTE24, respectively, that result in failure to process the lamin A precursor and accumulate permanently farnesylated forms of prelamin A. The farnesyl transferase inhibitor (FTI) lonafarnib is known to correct the aberrant nuclear morphology of HGPS patient cells and improves lifespan in children with HGPS. Importantly, and in contrast to a previous report, we show here that FTI treatment also improves the aberrant nuclear phenotypes in MAD-B patient cells with mutations in ZMPSTE24 (P248L or L425P). As expected, lonafarnib does not correct nuclear defects for cells with lamin A processing-proficient mutations. We also examine prelamin A processing in fibroblasts from two individuals with a prevalent laminopathy mutation LMNA-R644C. Despite the proximity of residue R644 to the prelamin A cleavage site, neither R644C patient cell line shows a prelamin A processing defect, and both have normal nuclear morphology. This work clarifies the prelamin A processing status and role of FTIs in a variety of laminopathy patient cells and supports the FDA-approved indication for the FTI Zokinvy for patients with processing-deficient progeroid laminopathies, but not for patients with processing-proficient laminopathies.
Additional file 1 of Evolution and biogeography of apple stem grooving virus
Creators: name: Shokri, Shohreh
name: Shujaei, Kamal
name: Gibbs, Adrian J.
name: Hajizadeh, Mohammad
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
Hyperfine interaction in InAs/GaAs self-assembled quantum dots : dynamical nuclear polarization versus spin relaxation
Creators: name: Krebs, O.
name: Eble, B.
name: Lemaître, A.
name: Voisin, P.
name: Urbaszek, B.
name: Marie, X.
name: Amand, T.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We report on the influence of hyperfine interaction on the optical orientation of singly charged excitons X+ and X- in self-assembled InAs/GaAs quantum dots. All measurements were carried out on individual quantum dots studied by micro-photoluminescence at low temperature. We show that the hyperfine interaction leads to an effective partial spin relaxation, under 50kHz modulated excitation polarization, which becomes however strongly inhibited under steady optical pumping conditions because of dynamical nuclear polarization. This optically created magnetic-like nuclear field can become very strong (up to ~4 T) when it is generated in the direction opposite to a longitudinally applied field, and exhibits then a bistability regime. This effect is very well described by a theoretical model derived in a perturbative approach, which reveals the key role played by the energy cost of an electron spin flip in the total magnetic field. Eventually, we emphasize the similarities and differences between X+ and X- trions with respect to the hyperfine interaction, which turn out to be in perfect agreement with the theoretical description.
description: 10 pages, 5 figures
Trading radical for incremental change: the politics of a circular economy transition in the German packaging sector
Creators: name: Simoens, Machteld Catharina
name: Leipold, Sina
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Understanding environmental politics is crucial for sustainability transitions. We study the transition politics of the shift to a circular economy in the German packaging sector, particularly the curious case of the 2019 German Packaging Act. While the policy was born out of the unanimous wish for radical regulatory change, all actors evaluate the outcome as incremental. Following the Discursive Agency Approach and drawing upon actor interviews and documents, we show that actors’ perceived fears of radical changes are critical for transition politics. This fear created a lock-in of two narratives, proposing conflicting organizational designs of packaging waste management. While the narrative lock-in was resolved by trading radical for incremental change, it left many conflicts and challenges unresolved. Our findings suggest that actors’ fears not only prevent radical regulatory change but also create incremental change that may intensify unresolved conflicts and, thus, further weaken the actors’ capacities for future transition politics.
On the maximum entropy principle and the minimization of the Fisher information in Tsallis statistics
Creators: name: Furuichi, Shigeru
Publisher: name: arXiv
Year: 2010
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We give a new proof of the theorems on the maximum entropy principle in Tsallis statistics. That is, we show that the $q$-canonical distribution attains the maximum value of the Tsallis entropy, subject to the constraint on the $q$-expectation value and the $q$-Gaussian distribution attains the maximum value of the Tsallis entropy, subject to the constraint on the $q$-variance, as applications of the nonnegativity of the Tsallis relative entropy, without using the Lagrange multipliers method. In addition, we define a $q$-Fisher information and then prove a $q$-Cramér-Rao inequality that the $q$-Gaussian distribution with special $q$-variances attains the minimum value of the $q$-Fisher information.
The geography of trust: understanding differences in perceptions of risk, water resources, and regional development
Creators: name: Ormerod, Kerri Jean
name: Kelley, Scott
name: Redman, Samantha
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: 111714 Mental Health
subject: FOS: Health sciences

description: This article draws on cultural theory of risk to explore public perceptions of trust in groups that provide information about water in the Reno-Sparks region of northern Nevada, USA. We survey 474 respondents, and using mixed-methods analysis, critically examine perceptions of trust in 12 sources to provide accurate information about water resources. Factor analysis reveals that respondents shared similar values of trust in several sources, which we categorize as: elected local officials, ancillary safeguards, local water and sanitation utilities, and supplemental sources. We then explored subregional variation in trust and local context, gleaned from open-ended responses. In conclusion, we find in the Reno-Sparks region as a whole there is general mistrust in elected local officials, however these perceptions are complicated by local context with some subregions more trusting than others.
Generalized E(7(7)) coset dynamics and D=11 supergravity
Creators: name: Hillmann, Christian
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The hidden on-shell E(7(7)) symmetry of maximal supergravity is usually discussed in a truncation from D=11 to four dimensions. In this article, we reverse the logic and start from a theory with manifest off-shell E(7(7)) symmetry inspired by West's coset construction. Following de Wit's and Nicolai's idea that a 4+56 dimensional "exceptional geometry" underlies maximal supergravity, we construct the corresponding Lagrangian and the supersymmetry variations for the 56 dimensional subsector. We prove that both the dynamics and the supersymmetry coincide with D=11 supergravity in a truncation to d=7 in the expected way.
description: 42 pages, v2: references added
Additional file 1 of Non-invasive investigation of Polychromophilus parasite infections in bat populations in Serbia using bat flies
Creators: name: Bajić, Branka
name: Werb, Oskar
name: Budinski, Ivana
name: Blagojević, Jelena
name: Schaer, Juliane
name: van Schaik, Jaap
Publisher: name: figshare
Year: 2023
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 1. Table S1: Primer names, sequences and sources of protocols used for their amplification; Table S2: GenBank accession numbers of previously published sequences of cytb and cox1 genes of Polychromophilus melanipherus; Table S3: Overview of Polychromophilus melanipherus cytb and cox1 haplotypes obtained; Figure S1: Haplotype network of concatenated sequences of genes cytb and cox1 of Polychromophilus melanipherus 1524 bp long.
A survey of the specificity and mechanism of 1,6 hexanediol-induced disruption of nuclear transport
Creators: name: Barrientos, Elizabeth C. Riquelme
name: Otto, Tegan A.
name: Mouton, Sara N.
name: Steen, Anton
name: Veenhoff, Liesbeth M.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified

description: Selective transport through the nuclear pore complex (NPC) depends on the dynamic binding of FG-repeat containing nucleoporins, the FG-nups, with each other and with Karyopherins (Kaps). Here, we assessed the specificity and mechanism by which the aliphatic alcohol 1,6-hexanediol (1,6HD) disrupts the permeability barrier of NPCs in live baker’s yeast cells. After a 10-minute exposure to 5% 1,6HD, no notable changes were observed in cell growth, cytosolic pH and ATP levels, or the appearance of organelles. However, effects on the cytoskeleton and Hsp104 were noted. 1,6HD clearly affected the NPC permeability barrier, allowing passive nuclear entry of a 177kDa reporter protein that is normally confined to the cytosol. Moreover, multiple Kaps were displaced from NPCs, and the displacement of Kap122-GFP correlated with the observed passive permeability changes. 1,6HD thus temporarily permeates NPCs, and in line with Kap-centric models, the mechanism includes the release of numerous Kaps from the NPCs.
Additional file 4 of The prevalence of multimorbidity and its association with physical activity and sleep duration in middle aged and elderly adults: a longitudinal analysis from China
Creators: name: He, Li
name: Biddle, Stuart J. H.
name: Lee, John Tayu
name: Duolikun, Nadila
name: Zhang, Lin
name: Wang, Zijie
name: Zhao, Yang
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Science Policy
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Additional file 4: Table S3. Unadjusted results of regression analyses.
Fast Amplification of QMA
Creators: name: Nagaj, Daniel
name: Wocjan, Pawel
name: Zhang, Yong
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Given a verifier circuit for a problem in QMA, we show how to exponentially amplify the gap between its acceptance probabilities in the `yes' and `no' cases, with a method that is quadratically faster than the procedure given by Marriott and Watrous. Our construction is natively quantum, based on the analogy of a product of two reflections and a quantum walk. Second, in some special cases we show how to amplify the acceptance probability for good witnesses to 1, making a step towards the proof that QMA with one-sided error is equal to QMA. Finally, we simplify the filter-state method to search for QMA witnesses by Poulin and Wocjan.
description: 15 pages
Optimization on conditions of podophyllotoxin-loaded liposomes using response surface methodology and its activity on PC3 cells
Creators: name: Wu, Zeyu
name: Wang, Tingting
name: Song, Yonghong
name: Lu, Yang
name: Chen, Tianyun
name: Chen, Pengpeng
name: Hui, Ailing
name: Chen, Yan
name: Wang, Haixiang
name: Zhang, Wencheng
Publisher: name: Taylor & Francis
Year: 2019
Subjects: Biophysics
Biochemistry
Physical Sciences not elsewhere classified
Medicine
Cell Biology
Neuroscience
Pharmacology
Chemical Sciences not elsewhere classified

description: The purpose of this study was to optimize the preparation conditions of podophyllotoxin liposomes (PPT-Lips), and to investigate their effects on PC3 cells. PPT-Lips were prepared by using a thin-film dispersion method. In order to achieve maximum drug encapsulation efficiency (EE), the process and formulation variables were optimized by response surface methodology (RSM). The optimum preparation conditions were cholesterol to lecithin ratio of 3.6:40 (w/w), lipid to drug ratio of 15.8:1 (w/w), and the ultrasonic intensity of 35% (total power of 400 W). The experimental EE of PPT-Lips was 90.425%, which was consistent with the theoretically predicted value. The characterization studies showed that PPT-Lips were well-dispersible spherical particles with an average size of 106 nm and a zeta potential of –10.1 mV. A gradual and time-dependent pattern of PPT from liposomes was found in in vitro drug release with a cumulative release amount up to 70.3% in 24 h. Results of cell viability experiments on PC3 cells demonstrated that PPT-Lips exhibited more effective anticancer activity in comparison with free PPT. Therefore, PPT-Lips represent an efficient and promising drug delivery system for PPT.
Differential contributions of nuclear lamina association and genome compartmentalization to gene regulation
Creators: name: Das, Priyojit
name: San Martin, Rebeca
name: McCord, Rachel Patton
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Chromatin regions that interact with the nuclear lamina are often heterochromatic, repressed in gene expression, and in the spatial B compartment. However, exceptions to this trend allow us to examine the relative impact of lamin association and spatial compartment on gene regulation. Here, we compared lamin association, gene expression, Hi-C, and histone mark datasets from cell lines representing different states of differentiation across different cell-type lineages. With these data, we compare, for example, gene expression differences when a B compartment region is associated with the nuclear lamina in one cell type but not in another. In general, we observed an additive rather than redundant effect of lamin association and compartment status. But, whether compartment status or lamin association had a dominant influence on gene expression varied by cell type. Finally, we identified how compartment and lamin association influence the likelihood of gene induction or repression in response to physicochemical treatment.
Trace inequalities for products of matrices
Creators: name: Furuichi, Shigeru
name: Kuriyama, Ken
name: Yanagi, Kenjiro
Publisher: name: arXiv
Year: 2010
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics

description: In this short paper, we study some trace inequalities of the products of the matrices and the power of matrices by the use of elementary calculations.
Additional file 1 of Perspectives on sleep of people living with dementia in nursing homes: a qualitative interview study
Creators: name: Dörner, Jonas
name: Hüsken, Johann-Moritz
name: Schmüdderich, Kathrin
name: Dinand, Claudia
name: Dichter, Martin N.
name: Halek, Margareta
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Supplementary Material 1
Berry Phase Effects on Electronic Properties
Creators: name: Xiao, Di
name: Chang, Ming-Che
name: Niu, Qian
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Ever since its discovery, the Berry phase has permeated through all branches of physics. Over the last three decades, it was gradually realized that the Berry phase of the electronic wave function can have a profound effect on material properties and is responsible for a spectrum of phenomena, such as ferroelectricity, orbital magnetism, various (quantum/anomalous/spin) Hall effects, and quantum charge pumping. This progress is summarized in a pedagogical manner in this review. We start with a brief summary of necessary background, followed by a detailed discussion of the Berry phase effect in a variety of solid state applications. A common thread of the review is the semiclassical formulation of electron dynamics, which is a versatile tool in the study of electron dynamics in the presence of electromagnetic fields and more general perturbations. Finally, we demonstrate a re-quantization method that converts a semiclassical theory to an effective quantum theory. It is clear that the Berry phase should be added as a basic ingredient to our understanding of basic material properties.
description: 48 pages, 16 figures, submitted to RMP
Constraining star cluster disruption mechanisms
Creators: name: Konstantopoulos, I. S.
name: Bastian, N.
name: Gieles, M.
name: Lamers, H. J. G. L. M.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Star clusters are found in all sorts of environments and their formation and evolution is inextricably linked to the star formation process. Their eventual destruction can result from a number of factors at different times, but the process can be investigated as a whole through the study of the cluster age distribution. Observations of populous cluster samples reveal a distribution following a power law of index approximately -1. In this work we use M33 as a test case to examine the age distribution of an archetypal cluster population and show that it is in fact the evolving shape of the mass detection limit that defines this trend. That is to say, any magnitude-limited sample will appear to follow a dN/dt=1/t, while cutting the sample according to mass gives rise to a composite structure, perhaps implying a dependence of the cluster disruption process on mass. In the context of this framework, we examine different models of cluster disruption from both theoretical and observational standpoints.
description: To appear in the proceedings of IAU Symposium 266: "Star Clusters: Basic Galactic Building Blocks Throughout Time And Space", eds. R. de Grijs and J. Lepine
Additional file 3 of A stable gene set for prediction of prognosis and efficacy of chemotherapy in gastric cancer
Creators: name: Wu, Rui
name: Guo, Sixuan
name: Lai, Shuhui
name: Pan, Guixing
name: Zhang, Linyi
name: Liu, Huanbing
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3: Supplemental Table S3. Clinical characteristics of two types*.
On Ruelle's construction of the thermodynamic limit for the classical microcanonical entropy
Creators: name: Kiessling, Michael K. -H.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: In this note we make a very elementary technical observation to the effect that Ruelle's construction of the thermodynamic limit of the classical entropy density defined with a regularized microcanonical measure actually establishes the thermodynamic limit for the entropy density defined with the proper microcanonical measure. At this stage a key formula is still derived from the regularized measures. We also show that with only minor changes in the proof the regularization of the microcanonical measure is actually not needed at all.
description: Short communication (7p), accepted for publication in J.Stat.Phys
Additional file 2 of Perspectives on sleep of people living with dementia in nursing homes: a qualitative interview study
Creators: name: Dörner, Jonas
name: Hüsken, Johann-Moritz
name: Schmüdderich, Kathrin
name: Dinand, Claudia
name: Dichter, Martin N.
name: Halek, Margareta
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Supplementary Material 2
Additional file 1 of A stable gene set for prediction of prognosis and efficacy of chemotherapy in gastric cancer
Creators: name: Wu, Rui
name: Guo, Sixuan
name: Lai, Shuhui
name: Pan, Guixing
name: Zhang, Linyi
name: Liu, Huanbing
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Supplemental Table S1. Patients’ basic characteristics.
Efficient Optimal Minimum Error Discrimination of Symmetric Quantum States
Creators: name: Assalini, Antonio
name: Cariolaro, Gianfranco
name: Pierobon, Gianfranco
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: This paper deals with the quantum optimal discrimination among mixed quantum states enjoying geometrical uniform symmetry with respect to a reference density operator $ρ_0$. It is well-known that the minimal error probability is given by the positive operator-valued measure (POVM) obtained as a solution of a convex optimization problem, namely a set of operators satisfying geometrical symmetry, with respect to a reference operator $Π_0$, and maximizing $\textrm{Tr}(ρ_0 Π_0)$. In this paper, by resolving the dual problem, we show that the same result is obtained by minimizing the trace of a semidefinite positive operator $X$ commuting with the symmetry operator and such that $X >= ρ_0$. The new formulation gives a deeper insight into the optimization problem and allows to obtain closed-form analytical solutions, as shown by a simple but not trivial explanatory example. Besides the theoretical interest, the result leads to semidefinite programming solutions of reduced complexity, allowing to extend the numerical performance evaluation to quantum communication systems modeled in Hilbert spaces of large dimension.
description: 5 pages, 1 Table, no figures
SOME SCIENTIFIC VIEWS ABOUT CONSECUTIVE TRANSLATION
Creators: name: Nurillayeva, Sevinch
Publisher: name: Zenodo
Year: 2023

description: This article is devoted the specific features of consecutive translation. Oral translation is interlingual and intercultural mediation, which ensures that the addressee understands the maximum (or at least optimal) share of the total meaning inherent in the message by the sender. Interpreting is an activity carried out under stress, often at or near the limit of the interpreter's strength. Often, a consecutive interpreter has to deal with segments containing many hundreds of words and lasting several minutes.
Measurement of plasma cortisol and histometry of the interrenal gland of juvenile pre-smolt coho salmon (Oncorhynchus kisutch Walbaum) during cold temperature acclimation.
Creators: name: Allan, Gerald D.
Publisher: name: University of British Columbia
Year: 2011

description: Juvenile, pre-smolt coho salmon were subjected to a decrease in environmental temperature from 12°C (temperature of acclimation) to 2°C over a period of approximately 72 hours. During this time, plasma Cortisol values were estimated by the competitive protein binding (CPB) technique. In addition, an histometric analysis of the interrenal tissues of these fishes was performed as a measure of interregnal activity. Experimental results indicated that fluctuations in plasma Cortisol concentrations occurred within 120 hours of the initiation of temperature alteration. Control levels for plasma Cortisol were 2.9 ± 0.75 ug cortiso1/100 ml plasma (mean ±S.D.). Maximum plasma Cortisol concentration, observed at hour 84 after temperature alteration, was 27.0 ± 2.8 ug cortisol/100 ml plasma (mean ± S.E.). By hour 96 experimental cortisol values returned to a level just slightly above those of controls and did not change significantly after that time. Measurements of interrenal nuclear diameters showed a significant increase in interrenal activity 14 days after initiation of exposure to cold. This level of interrenal activity was maintained until the experiment was terminated (20 days exposure to cold). It is concluded from this study that during acclimation to cold temperature, plasma cortisol values of juvenile, pre-smolt coho salmon demonstrate an early and rapid increase (within 120 hours exposure to colder temperature) followed by an equally rapid decrease to a level just slightly above that of controls. Furthermore, it is concluded that juvenile, pre-smolt coho salmon treated in this manner show no histologically demonstrable increase in interrenal activity until well after plasma cortisol values have become stabilized at a level slightly above that of controls (14 days exposure to cold).
Additional file 1 of The feasibility of negative pressure wound therapy versus standard dressings in paediatric hand and foot burns protocol: a pilot, single-centre, randomised control trial
Creators: name: Lumsden, Emma
name: Kimble, Roy
name: McMillan, Catherine
name: Storey, Kristen
name: Ware, Robert S.
name: Griffin, Bronwyn
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. SPIRIT Checklist: Recommended items to address in a clinical trial protocol and related documents.
Residential development in the City of North Vancouver.
Creators: name: Amissah, Samuel Bentsi
Publisher: name: University of British Columbia
Year: 2011

description: This study examines the relationships between the residential density and prices of residential land in the Lonsdale Area of the City of North Vancouver during the period 1967-1970. Specifically it investigates the nature of the pattern of spatial relationship between the distribution of residential density and the distribution of land prices. It also identifies the extent to which the form of the relationship is associated with the nature of change in the residential density, and the distance from Lonsdale Avenue. The study area is divided into three sectors (Upper, Central and Lower Lonsdale) to facilitate identification of patterns in locations having distinct characteristics and unique site attributes. Similarly, the three blocks east and west of Lonsdale Avenue are included in the study area to enhance the identification of the effects of distance from Lonsdale Avenue. The technique used consists of a format, which is essentially a matrix-cum-grid, and which coincides with the cadastral map of the City in terms of streets, blocks and sectors. This format is the main vehicle used in organising and analysing the data for both density and price. The potential in the technique enhances an easy identification of changes, trends, and movement in both density and price, and the spatial relationship between them. The units of measurement are so selected that they aid measurability and comparability within each variable, and between them, thus helping in locating relationships. Due to wide margins of prices and fluctuations, the method of aggregation, or grouping averages, is used. The investigation establishes that there is a pattern of spatial relationship between the distribution of residential density and the distribution of land prices, and that this relationship is associated with the nature of change in the residential density, and the distance from Lonsdale Avenue. It concludes that: a) economic and social factors underly the increases in density and price, as well as the relationships between them; b) the period 1967-1970 was favourable for investment in apartment development, and fertile for speculation; c) the 1967 Zoning By-Laws, and the financial capacities of developers, direct and control residential densities to a large extent; d) depending on location and other attributes, land characteristics are both homogeneous and heterogeneous. The implications of these conclusions are evaluated in terms of apartment development policy for the City of North Vancouver, and in terms of the present state of our theoretical understanding of the subject of density and price. Areas for further research are suggested, and observations made on the methodology and technique applied in the study.
Electrically detected magnetic resonance using radio-frequency reflectometry
Creators: name: Huebl, H.
name: Starrett, R. P.
name: McCamey, D. R.
name: Ferguson, A. J.
name: van Beveren, L. H. Willems
Publisher: name: arXiv
Year: 2009
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The authors demonstrate readout of electrically detected magnetic resonance at radio frequencies by means of an LCR tank circuit. Applied to a silicon field-effect transistor at milli-kelvin temperatures, this method shows a 25-fold increased signal-to-noise ratio of the conduction band electron spin resonance and a higher operational bandwidth of > 300 kHz compared to the kHz bandwidth of conventional readout techniques. This increase in temporal resolution provides a method for future direct observations of spin dynamics in the electrical device characteristics.
description: 9 pages, 3 figures
Additional file 2 of The feasibility of negative pressure wound therapy versus standard dressings in paediatric hand and foot burns protocol: a pilot, single-centre, randomised control trial
Creators: name: Lumsden, Emma
name: Kimble, Roy
name: McMillan, Catherine
name: Storey, Kristen
name: Ware, Robert S.
name: Griffin, Bronwyn
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Consent form for participants.
Additional file 1 of Optimization of 177Lu-labelling of DOTA-TOC, PSMA-I&T and FAPI-46 for clinical application
Creators: name: Cankaya, Aylin
name: Balzer, Matthias
name: Amthauer, Holger
name: Brenner, Winfried
name: Spreckelmeyer, Sarah
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Supplementary information.
Cosmic Ray Feedback
Creators: name: Mathews, William G.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Cosmic rays produced or deposited at sites in hot cluster gas are thought to provide the pressure that forms X-ray cavities. While cavities have a net cooling effect on cluster gas, young, expanding cavities drive shocks that increase the local entropy. Cavities also produce radial filaments of thermal gas and are sources of cluster cosmic rays that diffuse through cavity walls, as in Virgo where a radio lobe surrounds a radial thermal filament. Cosmic rays also make the hot gas locally buoyant, allowing large masses of low entropy gas to be transported out beyond the cooling radius. Successive cavities maintain a buoyant outflow that preserves the cluster gas temperature and gas fraction profiles and dramatically reduces the cooling rate onto the central black hole.
description: 4 pages, 1 figure, to appear in proceedings of the conference "The Monster's Fiery Breath: Feedback in Galaxies, Groups, and Clusters", June 2009, Madison Wisconsin
Additional file 1 of A qualitative study of perception related to risky driving behavior in Debre Markos City, North West Ethiopia, 2021
Creators: name: Mazengia, Elyas Melaku
name: Kassie, Ayenew
name: Zewdie, Amare
name: Demissie, Getu Debalkie
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Supplementary Material 1