Characterizing Emerging Canine H3 Influenza Viruses
Creators: name: Martinez-Sobrido, Luis
name: Blanco-Lobo, Pilar
name: Rodriguez, Laura
name: Fitzgerald, Theresa
name: Zhang, Hanyuan
name: Nguyen, Phuong
name: Anderson, Christopher S.
name: Holden-Wiltse, Jeanne
name: Bandyopadhyay, Sanjukta
name: Nogales, Aitor
name: DeDiego, Marta L.
name: Wasik, Brian R.
name: Miller, Benjamin L.
name: Henry, Carole
name: Wilson, Patrick C.
name: Sangster, Mark Y.
name: Treanor, John J.
name: Topham, David J.
name: Byrd-Leotis, Lauren
name: Steinhauer, David A.
name: Cummings, Richard D.
name: Luczo, Jasmina M.
name: Tompkins, Stephen M.
name: Sakamoto, Kaori
name: Jones, Cheryl A.
name: Steel, John
name: Lowen, Anice C.
name: Danzy, Shamika
name: Tao, Hui
name: Fink, Ashley L.
name: Klein, Sabra L.
name: Wohlgemuth, Nicholas
name: Fenstermacher, Katherine J.
name: El Najjar, Farah
name: Pekosz, Andrew
name: Sauer, Lauren
name: Lewis, Mitra K.
name: Shaw-Saliba, Kathryn
name: Rothman, Richard E.
name: Liu, Zhen-Ying
name: Chen, Kuan-Fu
name: Parrish, Colin R.
name: Voorhees, Ian E. H.
name: Kawaoka, Yoshihiro
name: Neumann, Gabriele
name: Chiba, Shiho
name: Fan, Shufang
name: Hatta, Masato
name: Kong, Huihui
name: Zhong, Gongxun
name: Wang, Guojun
name: Uccellini, Melissa B.
name: García-Sastre, Adolfo
name: Perez, Daniel R.
name: Ferreri, Lucas M.
name: Herfst, Sander
name: Richard, Mathilde
name: Fouchier, Ron
name: Burke, David
name: Pattinson, David
name: Smith, Derek J.
name: Meliopoulos, Victoria
name: Freiden, Pamela
name: Livingston, Brandi
name: Sharp, Bridgett
name: Cherry, Sean
name: Dib, Juan Carlos
name: Yang, Guohua
name: Russell, Charles J.
name: Barman, Subrata
name: Webby, Richard J.
name: Krauss, Scott
name: Danner, Angela
name: Woodard, Karlie
name: Peiris, Malik
name: Perera, R. A. P. M.
name: Chan, M. C. W.
name: Govorkova, Elena A.
name: Marathe, Bindumadhav M.
name: Pascua, Philippe N. Q.
name: Smith, Gavin
name: Li, Yao-Tsun
name: Thomas, Paul G.
name: Schultz-Cherry, Stacey
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Research Article
Medicine and health sciences
Biology and life sciences
Research and analysis methods

description: The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) have caused many thousands or millions of respiratory infections in dogs in the United States. While no human infections with CIVs have been reported to date, these viruses could pose a zoonotic risk. In these studies, the National Institutes of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) network collaboratively demonstrated that CIVs replicated in some primary human cells and transmitted effectively in mammalian models. While people born after 1970 had little or no pre-existing humoral immunity against CIVs, the viruses were sensitive to existing antivirals and we identified a panel of H3 cross-reactive human monoclonal antibodies (hmAbs) that could have prophylactic and/or therapeutic value. Our data predict these CIVs posed a low risk to humans. Importantly, we showed that the CEIRS network could work together to provide basic research information important for characterizing emerging influenza viruses, although there were valuable lessons learned.