cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
QORAQALPOG'ISTON RESPUBLIKASI SHAROITIDA ERTA BAHORDA BODRING ETISHTIRISHNING ENG SAMARALI USULINI ANIQLASH
Creators: name: Allamjarova, Gulbaxar
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada, bodring o‘simligini erta bahorda Qaroqalpog‘iston Respublikasi sharoitida  etishtirishning eng qulay ekish usullarini aniqlash bo‘yicha olib borilgan  ilmiy taqdiqotlarning tahliliy natijalari va ishlab chiqarishga tavsiyalar keltirilgan.
The Mechanobiology of Articular Cartilage: Bearing the Burden of Osteoarthritis
Creators: name: McNulty, Amy L.
name: Guilak, Farshid
name: Sanchez-Adams, Johannah
name: O’Conor, Christopher J.
name: Leddy, Holly A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Articular cartilage injuries and degenerative joint diseases are responsible for progressive pain and disability in millions of people worldwide, yet there is currently no treatment available to restore full joint functionality. As the tissue functions under mechanical load, an understanding of the physiologic or pathologic effects of biomechanical factors on cartilage physiology is of particular interest. Here we highlight studies that have measured cartilage deformation at scales ranging from the macroscale to the microscale, as well as the responses of the resident cartilage cells, chondrocytes, to mechanical loading using in vitro and in vivo approaches. From these studies, it is clear that there exists a complex interplay between mechanical, inflammatory, and biochemical factors that can either support or inhibit cartilage matrix homeostasis under normal or pathologic conditions. Understanding these interactions is an important step toward developing tissue engineering approaches and therapeutic interventions for cartilage pathologies.
ПРАКТИКА И ИНСТРУМЕНТЫ ЭФФЕКТИВНОГО ВНЕДРЕНИЯ В ОБРАЗОВАТЕЛЬНУЮ ДЕЯТЕЛЬНОСТЬ ВОЕННЫХ ОБРАЗОВАТЕЛЬНЫХ ОРГАНИЗАЦИЙ ВЫСШЕГО ОБРАЗОВАНИЯ ЭЛЕМЕНТОВ ГЕЙМИФИКАЦИИ
Creators: name: Дерюгин А.А.
name: Крижановская Г.Н.
name: Сальников В.П.
name: Захарцев С.И.
name: Виноградова Е.В.
Publisher: name: Образование и право
Year: 2022
Subjects: безопасность государства
национальные интересы
образовательная деятельность
военные образовательные организации высшего образования
цифровизация
геймификация.

description: На основе правового и педагогического анализа изложены актуальные проблемы цифровизации военного образования в современных условиях. Проанализированы практические составляющие внедрения в образовательную деятельность военных образовательных организаций высшего образования элементов геймификации, выделены положительные стороны данного процесса, указаны проблемы и пути их решения, определены перспективные задачи. Сделан вывод о том, что геймификация образовательной деятельности в военных образовательных организациях высшего образования должна стать естественным и необходимым средством для формирования необходимых компетенций у будущих офицеров.
Almost automorphic solutions of discrete delayed neutral system
Creators: name: Adıvar, Murat
name: Koyuncuoglu, H. Can
Publisher: name: arXiv
Year: 2014
Subjects: subject: Functional Analysis (math.FA)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: Primary 39A10, 39A12, Secondary 39B72

description: We study almost automorphic solutions of the discrete delayed neutral dynamic system% \[ x(t+1)=A(t)x(t)+ΔQ(t,x(t-g(t)))+G(t,x(t),x(t-g(t))) \] by means of a fixed point theorem due to Krasnoselskii. Using discrete variant of exponential dichotomy and proving uniqueness of projector of discrete exponential dichotomy we invert the equation and obtain some limit results leading to sufficient conditions for the existence of almost automorphic solutions of the neutral system. Unlike the existing literature we prove our existence results without assuming boundedness of inverse matrix $A\left( t\right) ^{-1}$. Hence, we significantly improve the results in the existing literature. We provide two examples to illustrate effectiveness of our results. Finally, we also provide an existence result for almost periodic solutions of the system.
description: 16 pages in Journal of Mathematical Analysis and Applications, 2015
title: Implantable antennas for biomedical applications
Creators: name: Alrawashdeh, Rula
Publisher: name: University of Liverpool Repository
Year: 2015

description: Recently, the interest in implantable devices for biomedical telemetry has significantly increased. Amongst the different components of the implantable device, the antenna plays the most significant role in the wireless data transmission. However, the human body around the antenna alters its overall characteristics and absorbs most of its radiation. Therefore, this thesis is mainly focused on improving the antenna characteristics (bandwidth and radiation efficiency) to overcome the human body effect and investigating new structures that reduce the power absorption by the human body tissues. A novel antenna design methodology is developed and used to design new flexible implantable antennas of much lighter weight, larger radiation efficiency, and wider bandwidth than existing embedded antennas. These antennas work for multiple ((401-406 MHz) MedRadio, 433 MHz and 2.45 GHz ISM) bands which satisfy the requirements of low power consumption and wireless power transfer. This has been combined with thorough investigations of the antenna performance in the anatomical human body. New effective evaluation parameters such as the antenna orientation are investigated for the first time. New structures inspired by complementary and multiple split ring resonators (CSRRs and MSRRs) are designed. The structures are found to reduce the electric near field and hence the absorbed power which increases the radiated power accordingly. This new promising function of metamaterial based structures for implantable applications is investigated for the first time. The path loss (between pacemaker and glucose monitoring implantable antennas inside the anatomical body model) and (between an implantable and external antennas for a wireless power channel at 433 MHz) are estimated. Moreover, the optimum antenna type for on-in body communication is investigated. Loop antennas are found to outperform patch antennas in close proximity to the human body.
title: Efficient probabilistic structural response prediction for aircraft turbulence and offshore wave loading
Creators: name: Lambert, Luke
Publisher: name: University of Liverpool Repository
Year: 2015

description: This thesis takes an interdisciplinary approach to the problem of the aleatory uncertainty manifest in the design of engineering structures that are subject to random loading, with specific application to continuous gust loading on aircraft and wave loading on offshore structures. The main focus is on aircraft gust loading because this is the area in which more significant progress is made. A review of the literature on gust loading is carried out to evaluate the sufficiency of existing methods and the possibility of a unified certification model is discussed. In order to obtain reliable probabilistic design loads using conventional stochastic simulation techniques, a large number of simulations are required to derive probability distributions that have adequately low sampling variability in the area of interest. A novel method, called the Efficient Threshold Upcrossing method, is developed that reduces the required number of simulations by at least 2 orders of magnitude. The method is initially developed for the efficient derivation of short-term offshore structural response statistics and is subsequently applied to the modelling of aircraft response to continuous turbulence. The ETU method was successfully extended to take into account long-term statistics of nonlinear aircraft response and it was shown that reliable design exceedance curves can be obtained by as little as 4\% of the computational cost of the conventional method. The current methods for the computation of design loads for nonlinear aircraft are limited to discrete, `1~-~cosine' gust encounters as the continuous turbulence models are only applicable to linear aircraft response. However, the most significant outcome of this thesis is that this is no longer the case, because the ETU method provides a way to calculate nonlinear response statistics in the time domain at a significantly lower computational cost. Mathematical models of a simple offshore structure, and both linear and nonlinear aircraft, are developed and a more robust technique is introduced for simulating patches of continuous turbulence. These models, which have the ability to generate random inputs, are used to derive response probability distributions for each of the test structures. The results obtained by applying the new approaches to these data sets show that they offer a marked improvement in performance.
Physicians' Perceptions of Factors Influencing Adherence to Antibiotic Prophylaxis in Children with Sickle Cell Disease
Creators: name: Wurst, Keele E
name: Konrad, Thomas R
name: Sleath, Betsy L
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Background: Children with sickle cell disease (SCD) aged Staphylococcus pneumoniae and Haemophilus influenzae due to the inability of their spleen to protect against infection.
ПРИВЛЕЧЕНИЕ К СУБСИДИАРНОЙ ОТВЕТСТВЕННОСТИ ИНОГО КОНТРОЛИРУЮЩЕГО ДОЛЖНИКА ЛИЦА: ОБСТОЯТЕЛЬСТВА, ПОДЛЕЖАЩИЕ ДОКАЗЫВАНИЮ
Creators: name: Муталиева А.А.
Publisher: name: Образование и право
Year: 2022
Subjects: банкротство (несостоятельность)
субсидиарная ответственность
иное контролирующее должника лицо
инициатор
бенефициар.

description: Несмотря на легальное определение понятия контролирующего должника лица и критериев отнесения лица к контролирующему, указания возможностей, посредством которых лицо определяет действия должника, в законодательстве содержится положение о лице, имеющем возможность «иным образом определять действия должника». Указанное лицо в науке и практике получило название иное контролирующее должника лицо. На сегодняшний день возникла тенденция расширения толкования термина «контролирующее должника лицо», в связи с чем суды зачастую исследуют не все существенные обстоятельства дела в рамках привлечения к субсидиарной ответственности, что приводит к необоснованному привлечению к ответственности невиновных лиц. В настоящей статье автором предпринята попытка обозначить проблему отнесения лица к числу контролирующих, а также основные элементы состава правонарушения, за которое контролирующие лица привлекаются к субсидиарной ответственности.
Choice of atypical antipsychotic therapy for patients with schizophrenia: An analysis of a medicaid population
Creators: name: Liu, Gordon G.
name: Sun, Shawn X.
name: Christensen, Dale B.
name: Zhao, Zhongyun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: In patients treated at Veterans Affairs facilities, demographicand clinical characteristics have been found to influence the choice of atypical antipsychotic drugs. However, little is known about the influences on the choice between olanzapine and risperidone in patients with schizophrenia enrolled in Medicaid.
title: The role of regulator of calcineurin 1 (RCAN1) signalling in endothelial cells
Creators: name: Alghanem, Ahmad
Publisher: name: University of Liverpool Repository
Year: 2015

description: Regulator of calcineurin 1 (RCAN1) has been shown to act as a negative regulator of vascular endothelial growth factor (VEGF)-signalling in endothelial cells. Two isoforms are detectable in cells, RCAN1.1 and RCAN1.4, produced by alternative splicing of the RCAN1 mRNA. In this study it was demonstrated that only RCAN1.4 is induced in human dermal microvascular endothelial cells (HDMECs) in response to VEGF. Using siRNA-mediated gene silencing this work shows that RCAN1 depletion leads to a reduction in VEGFR-2 internalisation following VEGF-A stimulation. RCAN1 depletion also leads to a reduction in cell polarity and cytoskeletal reorganisation in response to VEGF. siRNA-mediated silencing of RCAN1 led to an inhibition of VEGF-A mediated migration of HDMECs. These effects of RCAN1 knockdown appear to be specific to VEGFR-2, as no apparent effect on hepatocyte growth factor receptor (HGFR) internalisation and cytoskeletal reorganisation and migration in response to HGF was observed in HDMECs. Over- expression of RCAN1.4 isoform using adenoviral mediated gene delivery resulted in increased migration of HDMECs in the absence of ligand. This effect was insensitive to the calcineurin inhibitor cyclosporine, indicating that RCAN1.4 was not operating through the classical calcineurin/NFAT pathway to regulate cell migration. Instead, the RCAN1.4 effect was sensitive to a small molecule VEGFR-2 kinase inhibitor, which blocked cell migration. This study also examined the role of phospholipase D (PLD) in endothelial cell function. By utilising siRNA for PLD1 and PLD2 it was shown that both PLD1 and PLD2 are required for VEGF-A mediated proliferation, migration and tubular morphogenesis in HDMECs. Overall, the data presented in this thesis defines a novel role for both RCAN1 and PLD in regulating in endothelial cell function. Both proteins could be potential therapeutic targets to regulate vascular function.
title: Adolescents' evaluation of Dialectical behavior therapy
Creators: name: Archard, Rachael
Publisher: name: University of Liverpool Repository
Year: 2013

description: There is a large amount of research on BPD which highlights the pervasive and distressing nature of this disorder along with its resulting high financial cost to services. Previous research exploring intervention options for BPD have found DBT to beneficial in reducing parasuicidal behaviour and it is acknowledged as the intervention of choice for adults. The research evidence on ‘what works’ for adolescents with BPD is limited, although DBT is an intervention offered in clinical practice. This study aims to contribute to the research on the effectiveness of DBT by exploring adolescents’ experience of receiving this therapy. Five participants took part in the study and verbatim transcripts from their interviews were analysed using Thematic Analysis. The aim of the analysis was to develop understanding on what adolescents found to be the most and least helpful aspects of DBT and to help ascertain whether participants viewed this therapy as effective in reducing their presenting difficulties. Results identified four main themes which were constructed from the data set; ‘Clinical Picture’, ‘Deciding to start DBT’, ‘Evaluation of DBT’ and ‘Change’, with each theme containing between two and six sub-themes. The themes were seen to connect with each other to represent participants’ journey through therapy. Clinical implications of the research indicate that clinicians play an important role in the process of therapy and contribute to both positive and negative experiences. It appears there is a need for clinicians working with this client group to be appropriately trained and skilled to provide flexible care. In addition the findings from the current study suggest DBT did not target the multiple and varied problems the adolescents presented with, resulting in on-going difficulties and high levels of disengagement and drop-out rates. Whilst participants felt the intervention contained positive elements, overall they reported dissatisfaction with the outcome of therapy. Services may therefore need to consider alternative or additional intervention options to target adolescents’ presenting difficulties and help improve their quality of life.
ПРЕДМЕТ ДОКАЗЫВАНИЯ КАК ПРАВОВОЕ СРЕДСТВО ЗАЩИТЫ ПРАВ И ЗАКОННЫХ ИНТЕРЕСОВ НЕСОВЕРШЕННОЛЕТНЕГО ОБВИНЯЕМОГО
Creators: name: Чурилов С.Н.
Publisher: name: Образование и право
Year: 2022
Subjects: общий предмет доказывания
структура
содержание
видовой предмет доказывания
источники формирования.

description: В статье рассматривается проблема общего предмета доказывания, содержащего в ст. 73 УПК РФ, а также вопросы его интерпретации применительно к предмету доказывания по уголовным делам о преступлениях, совершенных несовершеннолетними. Вносятся предложения по совершенствованию структуры и содержания общего предмета доказывания как источника видового предмета доказывания по делам в отношении несовершеннолетних.
title: Antigen expression and host-parasite interactions of Plasmodium falciparum infections in Malawian paediatric patients
Creators: name: Tembo, Dumizulu
Publisher: name: University of Liverpool Repository
Year: 2014

description: Introduction: The process of sequestration involving specific cytoadhesion between parasite ligands expressed on the surface of the parasitised red blood cells (pRBC) and host vascular endothelium contributes to pathogenesis of severe falciparum malaria. A major polymorphic surface antigen implicated in cytoadhesion is the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 is encoded by the var multigene family that is sub-divided into three main groups: A, B and C, according to sequence similarities in coding and non-coding sequences. PfEMP1 has variant adhesive phenotypes, some of which interact with ABO blood groups to form rosettes and some involved in apparent formation of platelet-mediated clumps of infected erythrocytes that are thought to contribute to disease severity. With heavy HIV burden concentrating in areas with high malaria rates, co-infections are common. Both HIV and malaria interact with the host immune system, resulting in a complex activation of immune cells and subsequent dysregulated production of cytokines and antibodies. However, there is limited information on the molecular mechanisms of interaction between the two infections. Methods: Real time PCR was used to: 1) compare abundance of the three main var groups and measure the level of cytokine production and receptor expression utilising the resources of a clinicopathological study of 20 Malawian fatal paediatric malaria patients divided into three diagnostic groups: circulating and sequestered parasites (CM1); circulating and sequestered parasites plus perivascular pathology (CM2) and parasitaemic control (PC) groups; and 2) determine the effect of host ABO blood group on expression of var/PfEMP1 subtypes mediating platelet-mediating clumping in 65 Malawian paediatric patients with uncomplicated malaria (UM). Results: While there were no significant associations between ABO blood antigen groups with the clumping phenotype in UM patients, an abundance of var upsA and C transcripts were expressed in CM2 and the PC (p ≤ 0.001) groups. However, a very different expression pattern was observed in the CM1 group, which were mostly HIV positive (80%), with var gene group upsB being more abundant than in the other two diagnostic groups ( p ≤ 0.001). This result was supported by different cytokine/receptor upregulation between HIV positive and HIV negative children, with significant upregulation of TNF in HIV negative children (p ≤ 0.05). Conclusions: This data suggests that perivascular pathogenesis in naturally infected children is associated with differential var gene expression in the body. HIV disruption of cytokine release affects receptor regulation and influences parasite antigen expression.
Stueckelberg interferometry using periodically driven spin-orbit coupled Bose-Einstein condensates
Creators: name: Olson, Abraham J.
name: Blasing, David B.
name: Qu, Chunlei
name: Li, Chuan-Hsun
name: Niffenegger, Robert J.
name: Zhang, Chuanwei
name: Chen, Yong P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We study the single-particle dispersion of a spin-orbit coupled (SOC) Bose-Einstein condensate (BEC) under the periodical modulation of the Raman coupling. This modulation introduces a further coupling of the SOC dressed eigenlevels, thus creating a second generation of modulation-dressed eigenlevels. Theoretical calculations show that these modulation-dressed eigenlevels feature a pair of avoided crossings and a richer spin-momentum locking, which we observe using BEC transport measurements. Furthermore, we use the pair of avoided crossings to engineer a tunable Stueckelberg interferometer that gives interference fringes in the spin polarization of BECs.
Retirement Planning: The Role of Financial Literacy and Financial Education Programs
Creators: name: Khalid Saleh Salem Algoul
name: Dr. Regina John
Publisher: name: Zenodo
Year: 2023
Subjects: Retirement Planning, Investment Decision, Financial Education, Financial advisor, Financial Security

description: Abstract
Retirement planning involves a number of complex financial decisions, such as how much to save, how to invest savings, and how to manage income in retirement. Financial literacy and financial education programs can help people to make more informed decisions about their retirement planning. Studies have found that individuals with higher levels of financial literacy are more likely to save for retirement, invest in a diversified portfolio, and have a plan for managing their assets in retirement. Financial advisors can also play an important role in helping individuals with retirement planning. Financial advisors can provide individuals with personalized advice and guidance on how to develop and implement a retirement plan. This review article examines the role of financial literacy, financial education programs, and financial advisors in retirement planning. The article discusses the importance of financial literacy and financial education for retirement planning, and it reviews the evidence on the impact of financial literacy and financial education programs on retirement planning outcomes. The article also discusses the role of financial advisors in retirement planning and provides recommendations for how individuals can choose a financial advisor.
The Medicinal Chemistry of 5-HT6 Receptor Ligands with a Focus on Arylsulfonyltryptamine Analogs
Creators: name: Glennon, Richard A.
name: Sikazwe, Donald
name: Kolanos, Renata
name: Lee, Mase
name: Roth, Bryan L.
name: Dukat, Malgorzata
name: Bondarev, Mikhail L.
name: Siripurapu, Uma
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Arylsulfonyl analogs of aminopyrimidines (e.g. Ro 04-6790; 2), aminopyridines (e.g. Ro 63-0563; 3), 1-phenylpiperazines (e.g. SB-271046; 4), and tryptamines (e.g. MS-245; 5) were described as the first examples of selective 5-HT6 receptor antagonists only ten years ago. Today, hundreds of compounds of seemingly diverse structure have been reported. The early antagonists featured an arylsulfonyl group leading to the widespread assumption that an arylsulfonyl moiety might be critical for binding and antagonist action. With respect to the arylsulfonyltryptamines, it seems that neither the “arylsulfonyl” nor the “tryptamine” portion of these compounds is essential for binding or for antagonist action, and some such derivatives even display agonist action. The present review describes many of the currently available 5-HT6 receptor ligands and, unlike prior reviews, provides a narrative of the thinking (where possible) that led to their design, synthesis, and evaluation. The arylsulfonyltryptamines are also used as the structural basis of attempts to relate various structure-types to one another to afford a better understanding of the overall structural requirements for 5-HT6 receptor binding.
Grab and Go Guide: Small Steps, Big Vision - for realising the Ambitions Framework - March 2023
Creators: name: Borgstrom, Erica
name: Jordan, Joanne
name: Henry, Claire
name: St-Ledger, Una
Publisher: name: The Open University
Year: 2023
Subjects: Palliative care

description: This Grab-and-Go guide builds on research about how people use the Ambitions for Palliative and End of Life Care framework. The research was conducted by a team at The Open University. The research examined case studies and uncovered what helps and hinders people to realise the Ambitions. We found a wide range of practices and confidence levels when it came to using the framework, with many people not knowing where to start or how to progress. A focus on foundations enabled people to work towards multiple Ambitions.
 For each item, this guide provides: a description, prompts to get you thinking, and examples in action. You can use this guide for your own reflection, to facilitate team discussions, or in work with partners and across systems. We have added two areas to focus on (9&10) to promote collaborative and cross-sector working.
 This guide helps you to identify areas you can act on –a starting block to turn small steps into the big vision.
 Graphic design provided by Helen Monaghan. Funding for the project provided by Marie Curie.
Integrative Approaches for Predicting In Vivo Effects of Chemicals from their Structural Descriptors and the Results of Short-Term Biological Assays
Creators: name: Low, Yen
name: Sedykh, Alexander
name: Rusyn, Ivan
name: Tropsha, Alexander
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Cheminformatics approaches such as Quantitative Structure Activity Relationship (QSAR) modeling have been used traditionally for predicting chemical toxicity. In recent years, high throughput biological assays have been increasingly employed to elucidate mechanisms of chemical toxicity and predict toxic effects of chemicals in vivo. The data generated in such assays can be considered as biological descriptors of chemicals that can be combined with molecular descriptors and employed in QSAR modeling to improve the accuracy of toxicity prediction. In this review, we discuss several approaches for integrating chemical and biological data for predicting biological effects of chemicals in vivo and compare their performance across several data sets. We conclude that while no method consistently shows superior performance, the integrative approaches rank consistently among the best yet offer enriched interpretation of models over those built with either chemical or biological data alone. We discuss the outlook for such interdisciplinary methods and offer recommendations to further improve the accuracy and interpretability of computational models that predict chemical toxicity.
title: Wissensmanagement als bibliothekarische Aufgabe
Creators: name: Jucknies, Regina
name: Ortseifen, Rüdiger
name: Arbeitsgemeinschaft Der Parlaments- Und Behördenbibliotheken
Publisher: name: Fachinformationszentrum der Bundeswehr
Year: 2024

description: Der Wiki-Service Bw im Fachinformationszentrum der Bundeswehr
Observation of transient superconductivity at the LaAlO$_3$/SrTiO$_3$ interface
Creators: name: Daptary, Gopi Nath
name: Kumar, Shelender
name: Kumar, Pramod
name: Dogra, Anjana
name: Budhani, R. C.
name: Kumar, Dushyant
name: Mohanta, N.
name: Taraphder, A.
name: Bid, Aveek
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We report the observation of a magnetic field assisted transient superconducting state in the two dimensional electron gas existing at the interface of LaAlO$_3$/SrTiO$_3$ heterostructures. This metastable state depends critically on the density of charge carriers in the system. It appears concomitantly with a Lifshitz transition as a consequence of the interplay between ferromagnetism and superconductivity and the finite relaxation time of the in-plane magnetization. Our results clearly demonstrate the inherently metastable nature of the superconducting state competing with a magnetic order in these systems. The co-existence of superconductivity and ferromagnetism in the conducting electronic layer formed at the interface of insulating oxides has thrown up several intriguing and as yet unanswered questions. An open question in this field is the energetics of the interplay between these two competing orders and the present observation goes a long way in understanding the underlying mechanism.
description: 11 pages, 14 figures
On strong coupling scales in (minimal) massive gravity
Creators: name: Bonifacio, James
name: Noller, Johannes
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Ghost-free massive gravity models generically have a strong coupling scale of $Λ_3 =(M_{\rm Pl} m^2)^{1/3}$. However, for one of these models - `minimal massive gravity' - it is not clear what this scale is in the subset of solutions with vanishing vector modes, since there are then no interactions at the scale $Λ_3$. We show that there are always scalar-tensor interactions at a scale arbitrarily close to $Λ_3$ around the Minkowski vacuum solution. This explicitly confirms and completes previous research establishing that $Λ_3$ effectively is the maximal strong coupling scale for all ghost-free (dRGT) massive gravity models (on Minkowski). In the process, we also revisit and clarify the construction of generic Lorentz-invariant massive gravity models, explicitly constructing an improved non-redundant expansion for these models.
description: 19 pages
ПРИЧИНЫ И УСЛОВИЯ ПРЕСТУПЛЕНИЙ В СФЕРЕ ОБОРОТА НАРКОТИЧЕСКИХ СРЕДСТВ И ПСИХОТРОПНЫХ ВЕЩЕСТВ, СОВЕРШАЕМЫХ НЕСОВЕРШЕННОЛЕТНИМИ
Creators: name: Кодзокова Л.А.
name: Айгозина. А.М.
name: Сафина Л.К.
Publisher: name: Образование и право
Year: 2022
Subjects: несовершеннолетние
преступления
наркотические средства
психотропные вещества
причины и условия.

description: Актуальность исследования вызвана тем фактом, что дети и подростки – крайне «опасный» элемент преступного мира. Дело в том, что они пользуются своим возрастом, понимая, что наказание им будет мягче или получится его избежать, а судья и вовсе может освободить от наказания даже за тяжкое преступление на основании ст. 92 УК РФ. Поэтому подростковая преступность крайне жестокая и имеет свои особенности. [1, C. 158-164] Цель: анализ причин и условий преступлений в сфере оборота наркотических средств и психотропных веществ, совершаемых несовершеннолетних. Методология исследования – философских, общенаучных и специально-юридических средств и способов познания, обеспечивающих объективность изучения вопросов по заданной проблематике. В результате обосновано отметить, что одной из глобальных проблем современного общества является распространение наркомании. Наркотики наносят вред здоровью граждан и создают угрозу для национальной безопасности многих государств. Особенно пагубно наркотики влияют на молодежь и подростков в силу возрастных особенностей. Когда речь идет о предотвращении распространения наркомании профилактические мероприятия должны быть важной частью образования и воспитания. Грамотная предупреждающая работа среди подростков дает заметную результативность, главное, чтобы она велась систематически. Правильные действия и акции, проведенные психологами, наркологами и соцработниками, обязательно станут удерживающим фактором и уменьшат число молодых людей, склонных к наркомании. Авторы приходят к выводу, что многие наркоманы употребляют, чтобы испытать состояние эйфории. По этой причине подростки начинают пробовать наркотики, попадая в неблагополучную компанию. Сверстники рассказывают им о необыкновенных ощущениях, иногда даже заставляют попробовать. Некоторые юноши и девушки так хотят показать родителям свою самостоятельность и свободу, попадая в наркотическую «ловушку».
Tuning hERG Out: Antitarget QSAR Models for Drug Development
Creators: name: Tropsha, Alexander
name: Silva, Meryck
name: Braga, Rodolpho
name: Muratov, Eugene
name: Andrade, Carolina
name: Fourches, Denis
name: Alves, Vinicius
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Several non-cardiovascular drugs have been withdrawn from the market due to their inhibition of hERG K+ channels that can potentially lead to severe heart arrhythmia and death. As hERG safety testing is a mandatory FDA-required procedure, there is a considerable interest for developing predictive computational tools to identify and filter out potential hERG blockers early in the drug discovery process. In this study, we aimed to generate predictive and well-characterized quantitative structure–activity relationship (QSAR) models for hERG blockage using the largest publicly available dataset of 11,958 compounds from the ChEMBL database. The models have been developed and validated according to OECD guidelines using four types of descriptors and four different machine-learning techniques. The classification accuracies discriminating blockers from non-blockers were as high as 0.83–0.93 on external set. Model interpretation revealed several SAR rules, which can guide structural optimization of some hERG blockers into non-blockers. We have also applied the generated models for screening the World Drug Index (WDI) database and identify putative hERG blockers and non-blockers among currently marketed drugs. The developed models can reliably identify blockers and non-blockers, which could be useful for the scientific community. A freely accessible web server has been developed allowing users to identify putative hERG blockers and non-blockers in chemical libraries of their interest (http://labmol.farmacia.ufg.br/predherg).
title: Utilising novel thiol-acrylate click reactions to synthesise controlled branched polymer emulsifiers
Creators: name: Auty, Samuel
Publisher: name: University of Liverpool Repository
Year: 2015

description: The formation of multi-functional thiol materials for “click” reactions in synthetic chemistry has been significantly under-represented due to added practices that are typically required when working with sulfur-containing compounds. An efficient and facile approach to approach to introducing multiple masked thiols at the surface of polyester dendritic materials is presented, avoiding these difficulties, by utilising a xanthate protecting group. One-pot xanthate deprotection and thiol-acrylate Michael additions from the xanthate-functional dendrimers (generation zero to two) has been accomplished for the first time, using three different acrylate substrates of varying chemistry. The dendrimers were fully characterised by 1H and 13C NMR, SEC and either electrospray or MALDI-TOF mass spectrometry, depending upon the generation and nature of the end groups. In a similar fashion, this one-pot methodology was extended to prepare twenty different surface functional LDHs via the use of xanthate functional ATRP dendritic macroinitiators (generation one to four) and six different acrylate monomers. Model reactions and kinetics studies showed that the presence of xanthates within the initiator structure did not complicate the ATRP of tBuMA. The LDHs were fully characterised by 1H NMR and SEC. In the final study, employing one-pot xanthate deprotection and thiol-acrylate Michael addition, four dendritic ATRP macroinitiators with hydrophobic and pH responsive peripheral functionalities were prepared. Polymeric surfactants comprised of LDHs and HPDs were synthesised, varying in end group composition using different dendritic macroinitiators, and through the use of mixed initiating system, using a non-dendritic component. O/w emulsions stabilised by surfactants comprised of linear polymers, LDHs, or mixed linear polymers/LDHs architectures showed coalescence over a long term stability study under neutral and acid conditions. In contrast, o/w emulsions stabilised by surfactants comprised of branched polymers, HPDs, or mixed branched polymer/HPDs architectures showed no coalescence over a long term stability study under neutral and acid conditions. Further dilution and thermal studies to probe emulsion systems stabilised via branched surfactant architectures resulted in emulsion breakdown.
title: Αντίστροφη μηχανική, σχεδιασμός και κατασκευή εξαρτημάτων μικρού στροβιλοαντιδραστήρα
title: Reverse engineering, design and construction of parts for a small jet engine
Creators: name: Ζωγραφος Πετρος
Publisher: name: Technical University of Crete
Year: 2022

description: Στην παρούσα Μεταπτυχιακή Διατριβή ακολουθήθηκαν τα διαδοχικά στάδια μιας
συνολικής διαδικασίας αντίστροφης μηχανικής για την μέτρηση, τον σχεδιασμό και την κατασκευή 3 τμημάτων, που απαρτίζουν τα ακίνητα μέρη του συμπιεστή ενός μικρού στροβιλοαντιδραστήρα. Τα τμήματα του συμπιεστή που κατασκευάστηκαν
χαρακτηρίζονται από αυξημένη πολυπλοκότητα και δυσκολία τόσο στη μέτρηση όσο και στην κατασκευή του, κωρίως λόγω του μικρού τους μεγέθους και της παρουσίας σταθερών πτερυγίων. Από τη συγκεκριμένη διαδικασία, η οποία περιγράφεται στα επόμενα κεφάλαια, φάνηκε ότι είναι δυνατή η κατασκευή τμημάτων μικρού στροβιλοαντιδραστήρα με τα μέσα που διατίθενται εντός των Εργαστηρίων ενός Τεχνολογικού Ιδρύματος, χωρίς πολύ σημαντικά προβλήματα, καθώς η εν λόγω κατασκευή βρίσκεται εντός των δυνατοτήτων που διατίθενται, τόσο σε υποδομές όσο και σε γνώση. Γενικά η όλη διαδικασία χαρακτηρίστηκε από μεγάλη επιτυχία και ανοίγει τον δρόμο για την εφαρμογή αντίστοιχης διαδικασίας και για άλλα τμήματα μικρών στροβιλοαντιδραστήρων στο μέλλον.
description: In this Master's Thesis, the stages of an overall reverse engineering process were followed for the measurement, design and manufacture of 3 parts, which make up the parts of a small turboreactor's compressor. The parts of the compressor that were manufactured are characterized by increased complexity and difficulty in both measuring and manufacturing, mainly due to their small size and the presence of fixed vanes. From this particular process, which is described in the following chapters, it has been shown that it is possible to manufacture parts of a small turboreactor with the means available within the Laboratories of a Technological Institution, without very significant problems, as such construction is within the  available  capabilities, both in infrastructure and knowledge. In general, the whole process was characterized by great success and creates the way for the application of a similar process for other parts of small turboreactors in the future.
ПРОЕКТНО-ДИФФЕРЕНЦИРОВАННЫЙ ПОДХОД К ОБУЧЕНИЮ ИНОСТРАННОГО ЯЗЫКА В УСЛОВИЯХ ДИСТАНЦИОННОГО ОБУЧЕНИЯ
Creators: name: Спиридонова М.Е.
Publisher: name: Образование и право
Year: 2022
Subjects: метод проектов
дистанционная форма обучения
межкультурная компетенция.

description: Реализация принципа дифференциации в рамках проектно-дифференцированного обучения предполагает в соответствии с идеей уровневой дифференциации выделение на каждой ступени обучения уровней сформированности навыков проектной деятельности в условиях дистанционного обучения. В статье изложен опыт реализации метода проектов в обучении студентов ИФКиС иностранному языку в условиях дистанционного обучения. Целью реализации метода проектов стала активизация познавательного интереса и развитие коммуникативных способностей студентов в процессе формирования межкультурной компетенции. Ценность метода проектов заключается в том, что его можно применять в рамках дистанционного обучения в целях активизации познавательного интереса студентов при формировании межкультурной компетенции с целью развития коммуникативных способностей.
Heterospecific interactions and the proliferation of sexually dimorphic traits
Creators: name: Hurlbert, Allen H.
name: Pfennig, Karin S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Sexual selection is expected to promote speciation by fostering the evolution of sexual traits that minimize reproductive interactions among existing or incipient species. In species that compete for access to, or attention of, females, sexual selection fosters more elaborate traits in males compared to females. If these traits also minimize reproductive interactions with heterospecifics, then species with enhanced risk of interactions between species might display greater numbers of these sexual dimorphic characters. We tested this prediction in eight families of North American birds. In particular, we evaluated whether the number of sexually dimorphic traits was positively associated with species richness at a given site or with degree of sympatry with congeners. We found no strong evidence of enhanced sexual dimorphism with increasing confamilial species richness at a given site. We also found no overall relationship between the number of sexually dimorphic traits and overlap with congeners across these eight families. However, we found patterns consistent with our prediction within Anatidae (ducks, geese and swans) and, to a lesser degree, Parulidae (New World warblers). Our results suggest that sexually selected plumage traits in these groups potentially play a role in reproductive isolation.
Convergence theory for preconditioned eigenvalue solvers in a nutshell
Creators: name: Argentati, Merico E.
name: Knyazev, Andrew V.
name: Neymeyr, Klaus
name: Ovtchinnikov, Evgueni E.
name: Zhou, Ming
Publisher: name: arXiv
Year: 2014
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 49M37, 65F15, 65K10, 65N25

description: Preconditioned iterative methods for numerical solution of large matrix eigenvalue problems are increasingly gaining importance in various application areas, ranging from material sciences to data mining. Some of them, e.g., those using multilevel preconditioning for elliptic differential operators or graph Laplacian eigenvalue problems, exhibit almost optimal complexity in practice, i.e., their computational costs to calculate a fixed number of eigenvalues and eigenvectors grow linearly with the matrix problem size. Theoretical justification of their optimality requires convergence rate bounds that do not deteriorate with the increase of the problem size. Such bounds were pioneered by E. D'yakonov over three decades ago, but to date only a handful have been derived, mostly for symmetric eigenvalue problems. Just a few of known bounds are sharp. One of them is proved in [doi:10.1016/S0024-3795(01)00461-X] for the simplest preconditioned eigensolver with a fixed step size. The original proof has been greatly simplified and shortened in [doi:10.1137/080727567] by using a gradient flow integration approach. In the present work, we give an even more succinct proof, using novel ideas based on Karush-Kuhn-Tucker theory and nonlinear programming.
description: 12 pages, accepted for Foundations of Computational Mathematics 2015
ПРОТИВОДЕЙСТВИЕ ИНФОРМАЦИОННОМУ ВЛИЯНИЮ В УСЛОВИЯХ ЦИФРОВОЙ ТРАНСФОРМАЦИИ
Creators: name: Небродовская-Мазур Е.Ю.
name: Матвеева И.П.
Publisher: name: Образование и право
Year: 2022
Subjects: информационно-психологическое воздействие
переформатирование сознания
информационная война
«мягкая сила».

description: В статье рассмотрено влияние информации на сознание людей. Подчеркнуто, что в условиях масштабной информационной войны против России люди информационно дезориентированы и не способны адекватно оценивать и обрабатывать поступающую информацию. Происходит искажение массового сознания. В данных условиях необходимо наращивать влияние в информационном пространстве и налаживать эффективную работу государственной системы с целью противодействия информационно-психологической войне, в том числе посредством «мягкой силы». Подчеркивается, что воздействие «мягкой силы» заключается в комплексе инструментов и методов достижения внешнеполитических целей без применения оружия, а за счет информационных и других рычагов воздействия
Golgi polarity does not correlate with speed or persistence of freely migrating fibroblasts
Creators: name: Uetrecht, Andrea C.
name: Bear, James E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The polarization of the Golgi has long been thought to be important for cell migration. Here we show that Rat2 cells at the edge of an artificial wound repolarize the Golgi relative to the nucleus to face the direction of migration into the wound. However, in the absence of cues from neighboring cells, individual cells do not display Golgi polarity relative to the direction in which they are moving. Instead, the positioning of the Golgi relative to the nucleus remains relatively constant over time and does not reflect changes in the direction of migration. Consistent with this observation, we observe only a slight bias in Golgi positioning to the front of the nucleus and this bias is not higher during periods of time when the cell is moving in a persistent manner. Taken together, these data suggest that Golgi polarity is not a requirement for cell migration.
Transposable elements donate lineage-specific regulatory sequences to host genomes
Creators: name: Landsman, D.
name: Jordan, I.K.
name: Mariño-Ramírez, L.
name: Lewis, K.C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: The evolutionary implications of transposable element (TE) influences on gene regulation are explored here. An historical perspective is presented to underscore the importance of TE influences on gene regulation with respect to both the discovery of TEs and the early conceptualization of their potential impact on host genome evolution. Evidence that points to a role for TEs in host gene regulation is reviewed, and comparisons between genome sequences are used to demonstrate the fact that TEs are particularly lineage-specific components of their host genomes. Consistent with these two properties of TEs, regulatory effects and evolutionary specificity, human-mouse genome wide sequence comparisons reveal that the regulatory sequences that are contributed by TEs are exceptionally lineage specific. This suggests a particular mechanism by which TEs may drive the diversification of gene regulation between evolutionary lineages.
ПРОКУРОРСКИЙ РАБОТНИК КАК СУБЪЕКТ УЧЕБНОПРОФЕССИОНАЛЬНОЙ ДЕЯТЕЛЬНОСТИ В УСЛОВИЯХ ЦИФРОВОЙ ОБРАЗОВАТЕЛЬНОЙ СРЕДЫ
Creators: name: Шабаров Д.В.
name: Повжик О.Г.
Publisher: name: Образование и право
Year: 2022
Subjects: цифровизация
субъект учебной деятельности
пропедевтика
направленность
информационная платформа
повышение квалификации.

description: Статья посвящена реперным точкам развития системы непрерывного практико-ориентированного образования вновь назначенных прокуроров на местах, в условиях профессиональной среды на базе районной и специализированной прокуратуры. Также рассмотрены вопросы изучения направленности на прокурорскую деятельность посредством психодиагностики использования информационных платформ и перспективы развития системы профессиональной переподготовки в системе прокуратуры России. Отражена универсальность применения информационных платформ в цифровой образовательной среде, как эффективного способа коммуницирования в системе «преподаватель-слушатель» в конструкте организации профессиональной переподготовки прокурорских работников. Кроме того, рассмотрен способ диагностики направленности на прокурорскую деятельность посредством информационных платформ, как средства оперативного получения данных о профессиональных интересах и текущей успеваемости вновь назначенного прокурорского работника как субъекта учебной деятельности.
ПРОЦЕССУАЛЬНЫЕ ОСОБЕННОСТИ ОПРЕДЕЛЕНИЯ ФОРМЫ И РАЗМЕРА КОМПЕНСАЦИИ МОРАЛЬНОГО ВРЕДА, КАК СПОСОБА ЗАЩИТЫ ГРАЖДАНСКИХ ПРАВ
Creators: name: Соловьев В.Ю.
Publisher: name: Образование и право
Year: 2022
Subjects: моральный вред
компенсация морального вреда
защита гражданских прав
предмет доказывания
возмещение морального вреда.

description: В статье рассматриваются процессуальные особенности порядка разрешения споров о компенсации морального вреда, связанные с исключительно судебным порядком разрешения споров, неимущественным и самостоятельным исковым требованием, и возможностью предъявления совместно с иными требованиями. Устанавливается ряд критериев по формам и размеру компенсации морального вреда, которые оставляют судам широкий простор для своего рассмотрения по каждому конкретному делу. Поднимается вопрос о необходимости реформирования процедуры определения размеров компенсации морального вреда посредством введения новой методики, критериев, в том числе частных, и (или) введения границ размеров компенсируемого вреда.