cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
OpenRiskNet Part III: Modelling services in chemical/nano-safety, environmental science and pharmacokinetics
Creators: name: Kramer, Stefan
name: Doganis, Philip
name: Gebele, Denis
name: Raza, Atif
name: Karatzas, Pantelis
name: Haralambos  Sarimveis
name: Alvarsson, Jonathan
name: Spjuth, Ola
name: Arvidsson, Staffan
name: Exner, Thomas
name: Farcal, Lucian
name: Hardy, Barry
name: OpenRiskNet (EU Within Horizon 2020 EINFRA-22-2016; Project No. 731075)
Publisher: name: F1000 Research Limited
Year: 2019

description: The OpenRiskNet project (https://openrisknet.org/) is funded by the H2020-EINFRA-22-2016 Programme and its main objective is the development of an open e-infrastructure providing data and software resources and services to a variety of industries requiring risk assessment (e.g. chemicals, cosmetic ingredients, pharma or nanotechnologies).
The concept of case studies was followed in order to test and evaluate proposed solutions and is described in https://openrisknet.org/e-infrastructure/development/case-studies/. Two case studies, namely ModelRX and RevK, focus on modelling within risk assessment.
The ModelRX – Modelling for Prediction or Read Across case study provides computational methods for predictive modelling and support of existing data suitability assessment. It supports final risk assessment by providing calculations of theoretical descriptors, gap filling of incomplete datasets. computational modelling (QSAR) and predictions of adverse effects. Services are offered through Jaqpot (UI/API), JGU WEKA (API), Lazar (UI) and Jupyter & Squonk Notebooks.
In the RevK – Reverse dosimetry and PBPK prediction case study, physiologically based pharmacokinetic (PBPK) models are made accessible for the purpose of risk assessment-relevant scenarios. The PKSim software, the httk R package and custom-made PBPK models have been integrated. RevK offers services through Jaqpot (UI/API).
A Cross-Over in the Enstrophy Decay in Two-Dimensional Turbulence in a Finite Box
Creators: name: Yakhot, Victor
name: Wanderer, John
Publisher: name: arXiv
Year: 2004
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: The numerical simulation of two-dimensional decaying turbulence in a large but finite box presented in this paper uncovered two physically different regimes of enstrophy decay. During the initial stage, the enstrophy, generated by a random Gaussian initial condition, decays as t^{-gamma} with gamma approximately 0.7-0.8. After that, the flow undergoes a transition to a gas or fluid composed of distinct vortices. Simultaneously, the magnitude of the decay exponent crosses over to gamma approximately 0.4. An exact relation for the total number of vortices, N(t), in terms of the mean circulation of an individual vortex is derived. A theory predicting that N(t) is proportional to t^{-xi} and the magnitudes of exponents gamma=2/5 and xi=4/5 is presented and the possibility of an additional very late-time cross-over to gamma=1/3 and xi=2/3 is also discussed.
description: 11 pages, 7 figures
Dual functional nanoparticles efficiently across the blood–brain barrier to combat glioblastoma via simultaneously inhibit the PI3K pathway and NKG2A axis
Creators: name: Jin, Zheng
name: Lianhua Piao
name: Guangchao Sun
name: Chuanxiang Lv
name: Jing, Yi
name: Rihua Jin
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer

description: The blood–brain barrier (BBB) and complex tumour immunosuppressive micro-environment posed austere challenges for combatting brain tumours such as the glioblastoma. In this study, we have developed a novel dual functional dendrimer drug delivery system (DDS) by the PAMAM and loaded with siLSINCT5 (NP- siRNA) for efficiently across the BBB to inhibit glioblastoma. To achieve the goal of BBB crossing, on the surface of NP-siRNA was decorated with the cell penetrating peptides tLyp-1 (tLypNP-siRNA). Moreover, to overcome the immunosuppressive microenvironment within the glioblastoma (GBM) tissues, a checkpoint inhibitor named as anti-NKG2A monoclonal antibody (aNKG2A), which was able of promoting anti-tumour immunity by unleashing both T and NK Cells, was further conjugated on the surface of siLSINCT5-loaded nanoparticles via the pH-sensitive linkage. Therefore, the developed dual functional and siLSINCT5-loaded dendrimer nanoparticles (tLyp/aNKNP-siRNA) was supposed to have the ability to efficiently cross the BBB and inhibit GBM by simultaneously inhibit the LSINCT5-activated signalling pathways and activate the anti-tumour immunity. The hypothesis was thoroughly confirmed by in vitro cellular and in vivo animal experiments, and provided a novel strategy for combating glioblastoma.
Lorentz-Violating Running of Coupling Constants
Creators: name: Vieira, A. R.
name: Sherrill, N.
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We compute the full vacuum polarization tensor in the minimal QED extension. We find that its low-energy limit is dominated by the radiatively induced Chern-Simons-like term and the high-energy limit is dominated by the c-type coefficients. We investigate the implications of the high-energy limit for the QED and QCD running couplings. In particular, the QCD running offers the possibility to study Lorentz-violating effects on the parton distribution functions and observables such as the hadronic R ratio.
description: Presented at the Eighth Meeting on CPT and Lorentz Symmetry, Bloomington, Indiana, May 12-16, 2019
OpenRiskNet Part IV: WEKA machine learning services for the prediction of half-lifes of chemicals and nanoparticle transport
Creators: name: Kramer, Stefan
name: Gebele, Denis
name: Raza, Atif
name: OpenRiskNet (EU Within Horizon 2020 EINFRA-22-2016; Project No. 731075)
Publisher: name: F1000 Research Limited
Year: 2019

description: The OpenRiskNet project (https://openrisknet.org/) is funded by the H2020-EINFRA-22-2016 Programme and its main objective is the development of an open e-infrastructure providing data and software resources and services to a variety of industries requiring risk assessment (e.g. chemicals, cosmetic ingredients, pharma or nanotechnologies).
We will present the WEKA machine learning services within the infrastructure and how they can be used to solve complex prediction tasks: the prediction of (i) half-life of chemicals under given environmental conditions and of (ii) nanoparticle transport behavior from physicochemical properties. For that purpose, we will reconstruct previous efforts using complex workflows and architectures and simplify the models while maintaining their prediction performance. In both cases, the overall problem (predicting the fate of a compound depending on its properties and external conditions) is modeled as a cascaded prediction model, where the prediction of one model is, with particular attention to validity and performance, entering another model as input. The approach performs well on the half-life data, while the nanoparticle data are too noisy and incomplete to warrant more than the most basic models. Overall, the reconstruction of the two applications within OpenRiskNet provides more evidence for the power and versatility of the framework.
Additional file 1 of Anti-IgLON5 antibodies cause progressive behavioral and neuropathological changes in mice
Creators: name: Ni, You
name: Feng, Yifan
name: Shen, Dingding
name: Chen, Ming
name: Zhu, Xiaona
name: Zhou, Qinming
name: Gao, Yining
name: Liu, Jun
name: Zhang, Qi
name: Shen, Yuntian
name: Peng, Lisheng
name: Zeng, Zike
name: Yin, Dou
name: Hu, Ji
name: Chen, Sheng
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Hematology
subject: Cardiology

description: Additional file 1: Supplemental materials for the methodology section.
Zeuxo Templeton 1840
Creators: name: Edgar, Graham J.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Tanaidacea
Tanaididae
Zeuxo

description: Genus Zeuxo Templeton, 1840
 Diagnosis. Five pleonites present plus pleotelson. Antennule with four articles, first article over 2.5 times length of second article, terminal article with two to eight aesthetascs. Antenna with seven articles, article 2 longer than wide. Maxillule endite with eight large terminal spiniform setae, palp with several long setae. Labium outer lobe with small terminal process. Pereopod 1 coxa with anterior bulge. Pleopods similar, basis with one or two plumose setae on inner margin and three to eight setae on outer margin, endopod inner margin with one to six plumose setae. Uropod with four to seven articles, terminal article normal.
description: Published as part of Edgar, Graham J., 2008, Shallow water Tanaidae (Crustacea: Tanaidacea) of Australia, pp. 1-92 in Zootaxa 1836 (1) on page 46, DOI: 10.11646/zootaxa.1836.1.1, http://zenodo.org/record/5127398
Analysis of changes and developments in the organic cereal seed market based on a statistical evaluation of the German national organic seed database organicXseeds
Creators: name: Reusch, Babette
Publisher: name: Zenodo
Year: 2021
Subjects: organic seeds
cereals
organic regulation
organic agriculture

description: The Council Regulation (EC) No 834/2007 and the Commission Regulation (EC) No 889/2008 prescribe the use of organically produced seed in organic farming. As a result, the use of non-organic seed and propagating material can only be granted by applying for a derogation. To implement the guidelines, each member state shall provide a seed database to display seed offers from organic production and report statistical information about derogations to the European Commission. In this context, the LIVESEED project seeks to eliminate barriers to the availability of organic seed to ensure the use of 100% organic seed in organic farming from 2037. Thereby, national seed databases will be evaluated and improved.
 As part of the LIVESEED project, the aim of the study is to examine if data of web-based national organic seed databases can be used to analyse changes and developments in the organic seed market. For this purpose, data obtained from the crop group “cereals” of the German national seed database organicXseeds was revised and subsequently statistically evaluated. Furthermore, data about the yield per hectare and organic acreage of cereals was obtained by the Agricultural Market Information Society (AMI), the Federal Ministry of Food and Agriculture (BMEL) and the Statistical Offices of the Federal Government and the Federal States. In the further course, it could be clearly pointed out that a statistical analysis of the organicXseeds data enables detailed insights in the organic seed sector, revealing a number of factors that influence the use of seed from organic and conventional production in organic farming.
 Key points are that (a) the number of derogations for conventional seed in organic farming on organicXseeds is decreasing; nevertheless, no significant decreases could be identified and the objective of having no derogations at the key date of January 1st, 2036 can probably not be achieved for every cereal crop; therefore, (b) incentives have been worked out to reduce seed from conventional production in organic farming, concerning the introduction of category-I-crops (crops with sufficient quantities of seed from organic multiplication) and the improvement of the seed and cultivar supply in organic quality; (c) a significant, negative correlation between the supply of seed cultivars in organic quality and the number of requested seed cultivars in conventional quality via organicXseeds were detected; (d) the yield per hectare, which is influenced by external factors such as weather and the spread of diseases, could also be associated with the fluctuating request for conventional seed in organic farming.
title: Non-coding RNAs Function on Olfactory Sensory Neuron Development
Creators: name: Xu, Wenjing
Publisher: name: The Open University
Year: 2021

description: Neuronal plasticity in the brain is greatly enhanced early in life, during a time window referred to as the critical period. Mechanisms underlying heightened plasticity in this early developmental period remain largely unknown. Employing the murine olfactory sensory neuron (OSN) as a model, I identify the long non-coding RNA H19 as one important regulator of the developmental critical period. H19 is one of the most abundant transcripts in the early embryonic and neonatal olfactory epithelium. Although H19 knockout does not affect olfactory axon projection pattern, it affects plasticity during the critical period. H19 knockout mice are deficient in the ability to recover convergent axon projection following odorant exposure during the critical period. Transgenic expression of H19 in the OSNs disrupts the singular projection pattern of OSN axons. This effect is associated with the ability of H19 to influence the maturation of OSNs, and its ability to extend the lifespan of navigator OSNs, which exhibit dynamic axon growth during the critical period. In contrast, transgenic expression of H19 transcript without the embedded miR-675 does not affect the plasticity of OSN axon projection. These results suggest H19 regulates the olfactory neuron developmental plasticity through regulating miR-675 expression. I also investigated the role of ADAR, an enzyme that is involved in RNA editing and circular RNAs biogenesis, in the developmental of olfactory system. Adar-deficient OSNs display impaired axon targeting for certain olfactory receptor (OR) types. Transgenic expression of Adar1La, but not the isoform Adar1p150, widely downregulates circular RNAs. However, only ectopic expression of Adar1p150 disrupts olfactory axon projection. It is associated with an increase in neuronal activity. These results indicate that Adar influences axon projection during development, but this influence is unlikely to depend on circular RNA.
Probing Dark Energy Using Its Density Instead of Its Equation of State
Creators: name: Wang, Yun
name: Freese, Katherine
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The variation of dark energy density with redshift, $ρ_X(z)$, provides a critical clue to the nature of dark energy. Since $ρ_X(z)$ depends on the dark energy equation of state $w_X(z)$ through an integral, $ρ_X(z)$ can be constrained more tightly than $w_X(z)$ given the same observational data. We demonstrate this explicitly using current type Ia supernova (SN Ia) data [the Tonry/Barris sample], together with the Cosmic Microwave Background (CMB) shift parameter from CMB data (WMAP, CBI, and ACBAR), and the large scale structure (LSS) growth factor from 2dF galaxy survey data. We assume a flat universe, and use Markov Chain Monte Carlo (MCMC) technique in our analysis. We find that, while $w_X(z)$ extracted from current data is consistent with a cosmological constant at 68% C.L., $ρ_X(z)$ (which has far smaller uncertainties) is not. Our results clearly show the advantage of using $ρ_X(z)$, instead of $w_X(z)$, to probe dark energy.
description: One color figure showing w_X(z) versus rho_X(z), reconstructed model-independently from data. Submitted
Nonlinear rheology of Laponite suspensions under an external drive
Creators: name: Abou, Bérengère
name: Bonn, Daniel
name: Meunier, Jacques
Publisher: name: arXiv
Year: 2003
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We investigate the nonlinear rheological behavior of colloidal suspensions of Laponite, a synthetic clay, driven by a steady and homogeneous shear strain. We show that the external drive leads to a drastic slowing down of the aging dynamics or even, in some cases, in the rejuvenation of the system. Under shear, after a surprisingly long time, the spontaneous aging process observed at rest is suppressed. The system then reaches a non-equilibrium stationary state, characterised by a complex viscosity depending on the applied shear rate. In addition, the glass exhibits a non-Newtonian shear-thinning behavior. These rheological behaviors confirm recent numerical and theoretical predictions.
description: 17 pages, Latex, 6 figures, figures included in the body of the text, to appear in Journal of Rheology
MOESM4 of Qualitative and quantitative dermatoglyphics of chronic kidney disease of unknown origin (CKDu) in Sri Lanka
Creators: name: Buddhika Wijerathne
name: Meier, Robert
name: Sujatha Salgado
name: Suneth Agampodi
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Computational Biology

description: Additional file 4: Table S4. Palmar dermatoglyphics (triradii) of males.
title: Screening the Ubiquitination Components Essential for Cardiomyocyte Proliferation and Cardiac Regeneration
Creators: name: Vu, Diem My
Publisher: name: The Open University
Year: 2021

description: For several years, the inability to replace the lost myocardium has been studied intensively to define the mechanisms that restrict the regenerative capability of the adult heart. Multiple evidence have pointed out that the turnover of postnatal mammalian cardiomyocytes is affected by different crucial pathways. However, a thorough understanding of the intrinsic molecular mechanisms that regulate this process is still far from being complete.

 It has been more than a decade since various laboratories initialised the study of ubiquitination processes in the heart, reaching the unanimous conclusion that it plays a critical role in manipulating virtually all heart functions. However, there is fragmentary information about the molecular function of this system on the regulation of cardiomyocyte proliferation and even less on how this could be exploited for therapeutic purposes. Hence, expanding our knowledge on the ubiquitination might devise new strategies for cardiac regeneration.

 In this work, we present the identification of ubiquitination factors that are essential for cardiomyocyte replication, which was identified by harnessing the High Throughput Screening approach. An RNAi-based screening was performed, in which approximately 600 ubiquitination factors were silenced individually in primary neonatal cardiomyocytes. After that, the top siRNAs inhibiting proliferation were selected and investigated further to validate their functions in vitro. The validation identified UBE2G1, an E2 conjugation enzyme, as the most effective factor induced cardiomyocyte proliferation. The depletion of UBE2G1 not only suppressed cell cycle progression but also stimulated hypertrophy and counteracted the effects of pro-proliferative miRNAs. Administration of AAV9-UBE2G1 in neonatal mice promoted the cycling of cardiomyocytes while it preserved the heart function in adult mice at the early time points after myocardial infarction. Activation of GSK-3β, ERK1/2, and STAT3 signalling pathways correlated with UBE2G1 activity, whereas its interacting partners remained to be identified. In summary, we have revealed the implicit potential of ubiquitination factors and highlighted their promising therapeutic use in a heart regeneration scenario.
title: Engaging With Community: Exploring The Role Of Primary School Governing Boards In Developing And Implementing A ‘Vision’ For Special Educational Needs
Creators: name: Walker, Kim Alexandra
Publisher: name: The Open University
Year: 2021

description: This study explored how members of governing boards in two English primary schools developed and implemented a ‘vision’ for children considered to have Special Educational Needs (SEN). The research questions also examined the meaning of vision for governors in these schools and factors that enabled or constrained them in achieving their vision. The study drew on a sociocultural perspective and adopted a comparative case study methodology (Bryman 2004). A range of methods were used to explore the research question including: semi-structured interviews with members of the Governing Board and staff in each school; focus groups with parents and children; observations of governing board meetings and lessons; and a review of the SEN policy from both schools. The data was analysed by applying thematic analysis to identify themes from the study. This research drew on a conceptual framework described as the Community of Provision (Rix et al 2013). The framework supported analysis and evaluation of connections between the views and activities of members of the Governing Board with other members of their Community of Provision including staff, children, parents and policymakers. Findings revealed continuities and differences in meanings, activities and outcomes for governing boards in these schools. A key continuity was the roles afforded to values and relationships across the school community in achieving a vision for equitable support. The role of agency was also represented across these school communities. Differences which influenced the vision in both schools were linked to contextual factors including social, cultural and historical factors. These findings have implications for models of governance which allow boards to be responsive to their school communities. The findings also consider tensions arising from the notion of SEN in achieving a vision for equitable support. The study concludes by suggesting areas for future research.
Activities of daily living among elderly persons with severe aortic stenosis
Creators: name: Fukui, Shogo
name: Michiyuki Kawakami
name: Otaka, Yohei
name: Ishikawa, Aiko
name: Yashima, Fumiaki
name: Hayashida, Kentaro
name: Muraoka, Kaori
name: Meigen Liu
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: To determine the level of limitations in activities of daily living (ADL) and instrumental ADL, and identify related factors to instrumental ADL among elderly persons with severe aortic stenosis (AS). We prospectively enrolled 112 consecutive elderly persons (mean age, 84.6 ± 4.4 y) with severe AS. We assessed ADL and instrumental ADL using the Barthel index (BI) and the Frenchay activities index (FAI), respectively. Cardiac, physical, cognitive and kidney functions, nutritional status, medical histories, and comorbidities were assessed. A multiple logistic analysis was developed to explore related factors to the FAI. The medians (ranges) of BI and FAI were 100 (15–100) and 21 (0–38), respectively. The multiple logistic analysis revealed that a history of heart failure (sβ = −0.189), a history of cerebrovascular disease (sβ = −0.233), the short physical performance battery score ≤ 8 (sβ = −0.272), the mini-mental state examination score ≤ 23 (sβ = -0.168) were significantly related to the FAI (p Physical frailty, a history of heart failure, cerebrovascular disease, and cognitive decline were independently related to declined instrumental ADL.IMPLICATIONS FOR REHABILIATIONActivities of daily living was well-preserved among elderly persons with severe aortic stenosis.Instrumental activities of daily living varied among patients with aortic stenosis and was sometimes impaired.Physical frailty, a history of heart failure, and a history of cerebrovascular disease were independently associated with instrumental activities of daily living in elderly persons with severe aortic stenosis. Activities of daily living was well-preserved among elderly persons with severe aortic stenosis. Instrumental activities of daily living varied among patients with aortic stenosis and was sometimes impaired. Physical frailty, a history of heart failure, and a history of cerebrovascular disease were independently associated with instrumental activities of daily living in elderly persons with severe aortic stenosis.
Simplification of the Spectral Analysis of the Volume Operator in Loop Quantum Gravity
Creators: name: Brunnemann, Johannes
name: Thiemann, Thomas
Publisher: name: arXiv
Year: 2004
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Nuclear Theory (nucl-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The Volume Operator plays a crucial role in the definition of the quantum dynamics of Loop Quantum Gravity (LQG). Efficient calculations for dynamical problems of LQG can therefore be performed only if one has sufficient control over the volume spectrum. While closed formulas for the matrix elements are currently available in the literature, these are complicated polynomials in 6j symbols which in turn are given in terms of Racah's formula which is too complicated in order to perform even numerical calculations for the semiclassically important regime of large spins. Hence, so far not even numerically the spectrum could be accessed. In this article we demonstrate that by means of the Elliot -- Biedenharn identity one can get rid of all the 6j symbols for any valence of the gauge invariant vertex, thus immensely reducing the computational effort. We use the resulting compact formula to study numerically the spectrum of the gauge invariant 4 -- vertex. The techniques derived in this paper could be of use also for the analysis of spin -- spin interaction Hamiltonians of many -- particle problems in atomic and nuclear physics.
description: 56 pages, Latex2e, 15 pictures
Is the Hubble tension a hint of AdS phase around recombination?
Creators: name: Ye, Gen
name: Piao, Yun-Song
Publisher: name: arXiv
Year: 2020
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Anti-de Sitter (AdS) vacua, being theoretically important, might have an unexpected impact on the observable universe. We find that in early dark energy (EDE) scenarios the existence of AdS vacua around recombination can effectively lift the CMB-inferred $H_0$ value. As an example, we study a phenomenological EDE model with an AdS phase starting at the redshift $z\sim2000$ and ending shortly after recombination (hereafter the universe will settle down in a $Λ>0$ phase until now), and obtain a best-fit $H_0=72.74$ km/s/Mpc without degrading the CMB fit compared with the standard $Λ$CDM model.
description: 7 pages, 5 figures, matched published version in PRD
.Tendencias de innovación educativa con Moodle: llevando el cambio metodológico al aula.
Creators: name: Fidalgo-Blanco, Ángel
name: Sein-Echaluce, María Luisa
name: García-Peñalvo, F.J
Publisher: name: Zenodo
Year: 2019
Subjects: Innovación Educativa, Moodle, Tecnologías de aprendizaje, Tendencias de Innovación educativa

description: Una tendencia de innovación educativa es una nueva tecnología, metodología o producto que tiene grandes posibilidades de impactar en el modelo educativo produciendo una mejora del mismo. Una misma tendencia tiene dos puntos de análisis que son convergentes: el tecnológico y el metodológico. Desde el punto de vista tecnológico las tendencias se identifican por la novedad e impacto de la tecnología. Algunos ejemplos son: BlockChain, Realidad aumentada adaptativa y Ecosistemas de aprendizaje. Bajo este punto de vista, Moodle no se suele considerar una tendencia de innovación educativa. Sin embargo, en el contexto educativo las tendencias se centran más en el cambio del modelo de aprendizaje. Por ejemplo con las tendencias como: Aula Invertida, Gamificación, Aprendizaje adaptativo, Evaluación por evidencias o Inteligencia colectiva se centran en el cambio metodológico en el aula. Bajo este enfoque metodológico, Moodle es la plataforma reina en el mundo de las tendencias de innovación educativa. Eso sí, es un reinado silencioso y poco conocido. En esta charla se mostrarán las tendencias en innovación educativa más relevantes en el contexto del aula y el papel de Moodle como facilitador del éxito en la implantación de las mismas.
SUR-FeatNet: Predicting the Satisfied User Ratio Curvefor Image Compression with Deep Feature Learning
Creators: name: Lin, Hanhe
name: Hosu, Vlad
name: Fan, Chunling
name: Zhang, Yun
name: Mu, Yuchen
name: Hamzaoui, Raouf
name: Saupe, Dietmar
Publisher: name: arXiv
Year: 2020
Subjects: subject: Multimedia (cs.MM)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: The satisfied user ratio (SUR) curve for a lossy image compression scheme, e.g., JPEG, characterizes the complementary cumulative distribution function of the just noticeable difference (JND), the smallest distortion level that can be perceived by a subject when a reference image is compared to a distorted one. A sequence of JNDs can be defined with a suitable successive choice of reference images. We propose the first deep learning approach to predict SUR curves. We show how to apply maximum likelihood estimation and the Anderson-Darling test to select a suitable parametric model for the distribution function. We then use deep feature learning to predict samples of the SUR curve and apply the method of least squares to fit the parametric model to the predicted samples. Our deep learning approach relies on a siamese convolutional neural network, transfer learning, and deep feature learning, using pairs consisting of a reference image and a compressed image for training. Experiments on the MCL-JCI dataset showed state-of-the-art performance. For example, the mean Bhattacharyya distances between the predicted and ground truth first, second, and third JND distributions were 0.0810, 0.0702, and 0.0522, respectively, and the corresponding average absolute differences of the peak signal-to-noise ratio at a median of the first JND distribution were 0.58, 0.69, and 0.58 dB. Further experiments on the JND-Pano dataset showed that the method transfers well to high resolution panoramic images viewed on head-mounted displays.
Additional file 1 of CYP4 subfamily V member 2 (CYP4V2) polymorphisms were associated with ischemic stroke in Chinese Han population
Creators: name: Long, Faqing
name: Wang, Desheng
name: Su, Qingjie
name: Zhang, Yuhui
name: Li, Jianhong
name: Xia, Shiliang
name: Wang, Hailun
name: Wu, Yongping
name: Qu, Qiumin
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Additional file 1: Table S1. Primers sequence of PCR and UEP for CYP4V2 SNPs in this study. Table S2.The information about CYP4V2 SNPs and the association with IS susceptibility in allele model. Table S3. The potential functional SNPs in human CYP4V2 gene
Crack fronts and damage in glass at the nanometer scale
Creators: name: Marliere, C.
name: Prades, S.
name: Celarie, F.
name: Dalmas, D.
name: Bonamy, D.
name: Guillot, C.
name: Bouchaud, E.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: We have studied the low speed fracture regime for different glassy materials with variable but controlled length scales of heterogeneity in a carefully mastered surrounding atmosphere. By using optical and atomic force microscopy (AFM) techniques we tracked in real-time the crack tip propagation at the nanometer scale on a wide velocity range (mm/s - pm/s and below). The influence of the heterogeneities on this velocity is presented and discussed. Our experiments reveal also -for the first time- that the crack progresses through nucleation, growth and coalescence of nanometric damage cavities within the amorphous phase. This may explain the large fluctuations observed in the crack tip velocities for the smallest values. This behaviour is very similar to what is involved, at the micrometric scale, in ductile fracture. The only difference is very likely due to the related length scales (nanometric instead of micrometric). Consequences of such a nano-ductile fracture mode observed at a temperature far below the glass transition temperature in glass is finally discussed.
description: 12 pages, 8 figures, submitted to Journal of Physics: Condensed Matter; Invited talk at Glass and Optical Materials Division Fall 2002 Meeting, Pittsburgh, Pa, USA
title: An Isotopic Investigation Of Early Planetesimal Differentiation Processes
Creators: name: Windmill, Richard Joseph
Publisher: name: The Open University
Year: 2021

description: The differentiation and early evolution of planetesimals is relatively poorly understood. The Main Group pallasites (PMGs) and IIIAB irons are differentiated meteorite groups from deep planetesimal interiors. They provide a window into the early evolution of rocky planets because of the abundance of samples from these groups and because a common planetary provenance has been proposed. Oxygen isotope analyses are crucial in understanding these relationships. The mineralogy of the PMGs and IIIABs, which seemingly record the magmatic evolution of their parent body, offers a unique opportunity to study early planetary differentiation processes. High-precision oxygen isotope analyses are used in conjunction with petrological characteristics and Cr and W isotope analyses to subdivide these groups and investigate formation processes. Two subgroups are identified in PMGs: PMG-low and PMG-high. The former exhibits an oxygen isotopic disequilibrium between olivine and chromite that is unexplainable through known mass-dependent processes. These minerals therefore either sample multiple isotopic reservoirs mixed during an impact or, less likely, are affected by complex anharmonic or nuclear field shift effects. Further investigation on these effects must be executed to completely discount these latter possibilities. The PMG-high chromite isotope ratios probably record equilibration between these two reservoirs. Chromium and W isotope analyses on PMG samples show no disequilibrium but provide an excellent chronology. High-precision oxygen isotope analyses of IIIABs has identified three previously unknown subgroups with serious implications for the interpretation of the IIIAB suite of samples. These likely originate from different planetesimals and not from complex core evolution. Finally, chromite in PMGs and IIIABs is shown to be resolvable in Δ17O which precludes a common parent planetesimal. The findings of this study suggest that there may have been many more differentiated planetesimals in the early Solar System than previously thought and necessitate care in future studies linking meteorite groups by parent body.
MOESM5 of Qualitative and quantitative dermatoglyphics of chronic kidney disease of unknown origin (CKDu) in Sri Lanka
Creators: name: Buddhika Wijerathne
name: Meier, Robert
name: Sujatha Salgado
name: Suneth Agampodi
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology
subject: Computational Biology

description: Additional file 5: Table S5. Palmar dermatoglyphics (loops) of females.
Advances in neutral tungsten ultraviolet spectroscopy for the potential benefit to gross erosion diagnosis
Creators: name: Johnson, C. A.
name: Ennis, D. A.
name: Loch, S. D.
name: Hartwell, G. J.
name: Maurer, D. A.
name: Allen, S. L.
name: Victor, B. S.
name: Samuell, C. M.
name: Abrams, T.
name: Unterberg, E. A.
name: Smyth, R. T.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: A spectral survey of tungsten emission in the ultraviolet region has been completed in the DIII-D tokamak and the CTH torsatron to assess the potential benefit of UV emission for the diagnosis of gross W erosion. A total of 29 W I spectral lines are observed from the two experiments using survey spectrometers between 200-400 nm with level identifications provided based on a structure calculation for many of the excited states that produce strong emission lines. Of the 29 observed lines, 20 have not previously been reported in fusion relevant plasmas, including an intense line at 265.65 nm which could be important for benchmarking the frequently exploited line at 400.88 nm. Nearly all of the observed spectral lines decay down to one of the six lowest energy levels for neutral W, which are likely to be long-lived metastable states. The impact of metastable level populations on the W I emission spectrum and any erosion measurement utilizing a spectroscopic technique is potentially significant. Nevertheless, the high density of W I emission in the UV region allows for the possibly of determining the relative metastable fractions and plasma parameters local to the erosion region. Additionally, the lines observed in this work could be used to perform multiple independent gross erosion measurements, leading to more accurate diagnosis of gross tungsten erosion.
description: 16 pages, 6 figures
Patient readiness for risk-reduction education and lifestyle change following transient ischemic attack
Creators: name: Geldens, Nicholas
name: Crowfoot, Gary
name: Sweetapple, Anne
name: Glade Vyslysel
name: Mason, Gillian
name: English, Coralie
name: Janssen, Heidi
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Patient readiness for secondary prevention and lifestyle change following transient ischemic attack is not well understood. Understanding patient perspectives about the timing and delivery of secondary prevention education is essential to promote meaningful risk factor reduction in this population. A single, semi-structured, telephone interview was conducted with ten individuals (7 male, 3 female) within three months following a transient ischemic attack. Interviews explored transient ischemic attack experiences and post-event education. Data were analyzed using inductive thematic analysis. Individuals had a variety of experiences with secondary prevention education. Four themes emerged from these experiences including “what the hell happened?”, “I mustn’t have been quite ready”, “what should I be doing?” and “we all see it in different ways.” Individual knowledge, personal experience of transient ischemic attack, socio-environmental factors, and the format and content of education influenced patient readiness to receive secondary prevention education and adopt lifestyle changes. Readiness for risk-reduction education and lifestyle change following transient ischemic attack is individual and complex. Logistical factors including the location, time, and cost of education, timing of education delivery, and patient perspectives should be considered in the development and delivery of secondary prevention interventions for these people.Implications for rehabilitationRisk reduction and lifestyle change following transient ischemic attack is vital to prevent recurrent stroke.Patients are ready to receive risk reduction and lifestyle advice approximately one week after their transient ischemic attack.Programs designed to provide risk reduction and lifestyle education should be informed by the unique requirements of this population.Uptake of participation in secondary prevention programs may be maximized by offering flexibility in terms of timing post-event and modes of delivery (e.g. Telehealth). Risk reduction and lifestyle change following transient ischemic attack is vital to prevent recurrent stroke. Patients are ready to receive risk reduction and lifestyle advice approximately one week after their transient ischemic attack. Programs designed to provide risk reduction and lifestyle education should be informed by the unique requirements of this population. Uptake of participation in secondary prevention programs may be maximized by offering flexibility in terms of timing post-event and modes of delivery (e.g. Telehealth).
title: Exploring miRNAs as Modulators in Retinal Degeneration: Potential Therapeutic Tools for Inherited Retinal Dystrophies
Creators: name: Guadagnino, Irene
Publisher: name: The Open University
Year: 2021

description: Inherited retinal dystrophies (IRDs) are a large group of genetic diseases that lead to retinal degeneration and represent a major cause of vision impairment or blindness. The high genetic heterogeneity of IRDs hinders a broad application of gene-specific therapies. There is an unmet need for therapies that can target common pathological mechanisms, regardless of the genetic cause. MicroRNAs (miRNAs) are important players in retinal biology and my group has demonstrated that miR-204 has a pathogenic role in human IRDs. Due to their pleiotropic actions, miRNAs represent promising therapeutic tools. On this basis, I hypothesized that the modulation of miR-204 levels, as well as other miRNAs, could represent a valid approach to tackle retinal degeneration. The first part of my thesis elucidates the potential of miR-204 administration as a therapeutic approach for IRDs. I found that administration of miR-204 by an adeno-associated viral (AAV) vector at patient-relevant stages of disease progression led to a long-term preservation of retinal function in a mouse model for a dominant form of Retinitis Pigmentosa (RP). Interestingly, transcriptome analysis revealed that miR-204 effect is mediated by dampening pathological processes shared by different IRDs (e.g. innate immune response). The second part of my work was focused on identifying additional miRNAs that can exert a protective action in IRDs in a gene-independent manner. Using a High Content Screening (HCS) approach I tested 560 miRNAs in a model of oxidative stress-induced retinal degeneration, the light-damage in cone-like cells (661W). As a result, I found that miR-429 significantly preserved 661W viability during photo-stress. Further analysis revealed that miR-429 overexpression increases the activated form of the pro-survival AMP-activated protein kinase (AMPK), recently demonstrated to be protective during retinal degeneration. Overall, the results of this thesis indicate that modulation of miRNAs can be a promising approach to develop mutation-independent treatments for IRDs.
Spin Glasses: Model systems for non-equilibrium dynamics
Creators: name: Nordblad, Per
Publisher: name: arXiv
Year: 2003
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Spin glasses are frustrated magnetic systems due to a random distribution of ferro- and antiferromagnetic interactions. An experimental three dimensional (3d) spin glass exhibits a second order phase transition to a low temperature spin glass phase regardless of the spin dimensionality. In addition, the low temperature phase of Ising and Heisenberg spin glasses exhibits similar non-equilibrium dynamics and an infinitely slow approach towards a thermodynamic equilibrium state. There are however significant differences in the detailed character of the dynamics as to memory and rejuvenation phenomena and the influence of critical dynamics on the behaviour. In this article, some aspects of the non-equilibrium dynamics of an Ising and a Heisenberg spin glass are briefly reviewed and some comparisons are made to other glassy systems that exhibit magnetic non-equilibrium dynamics.
description: To appear in J. Phys.: Condens. Matter, Proceedings from HFM2003, Grenoble
Trésors monétaires S-O Gaule/N-E Ibérie (2e AF)
Creators: name: Hiriart, Eneko
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017

description: Inventaire des trésors monétaires du sud-ouest de la Gaule et du nord-est de la péninsule Ibérique, pour le second âge du Fer
Additional file 2 of International randomised controlled trial for the treatment of newly diagnosed EWING sarcoma family of tumours – EURO EWING 2012 Protocol
Creators: name: Anderton, Jennifer
name: Moroz, Veronica
name: Marec-Bérard, Perrine
name: Gaspar, Nathalie
name: Laurence, Valerie
name: Martín-Broto, Javier
name: Sastre, Ana
name: Gelderblom, Hans
name: Owens, Cormac
name: Kaiser, Sophie
name: Fernández-Pinto, Melissa
name: Fenwick, Nicola
name: Evans, Abigail
name: Strauss, Sandra
name: Whelan, Jeremy
name: Wheatley, Keith
name: Brennan, Bernadette
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: Additional file 2: Table S1. Summary of treatment details: the schedules of administration of cycles of chemotherapy and zoledronic acid.
Forward modeling of galaxy kinematics in slitless spectroscopy
Creators: name: Outini, Mehdi
name: Copin, Yannick
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Slitless spectroscopy has long been considered as a complicated and confused technique. Nonetheless, with the advent of Hubble Space Telescope (HST) instruments characterized by a low sky background level and a high spatial resolution (most notably WFC3), slitless spectroscopy has become an adopted survey tool to study galaxy evolution from space. We investigate its application to single object studies to measure not only redshift and integrated spectral features, but also spatially resolved quantities such as galaxy kinematics. We build a complete forward model to be quantitatively compared to actual slitless observations. This model depends on a simplified thin cold disk galaxy description -- including flux distribution, intrinsic spectrum and kinematic parameters -- and on the instrumental signature. It is used to improve redshifts and constrain basic rotation curve parameters, i.e. plateau velocity $v_{0}$ (in $\rm km.s^{-1}$) and central velocity gradient $w_{0}$ (in $\rm km.s^{-1}.arcsec^{-1}$). The model is tested on selected observations from 3D-HST and GLASS surveys, to estimate redshift and kinematic parameters on several galaxies measured with one or more roll angles. Our forward approach allows to mitigate the self-contamination effect, a primary drawback of slitless spectroscopy, and therefore has the potential to increase precision on redshifts. In a limited sample of well-resolved spiral galaxies from HST surveys, it is possible to significantly constrain galaxy rotation curve parameters. This proof-of-concept work is promising for future large slitless spectroscopic surveys such as EUCLID and WFIRST.
description: 13 pages, accepted for publication in A&A