cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Trasporto di vapori in sistemi polimerici: Aspetti interazionali ed evoluzione strutturale analizzati mediante spettroscopia vibrazionale in risoluzione temporale
Creators: name: La Manna, Pietro
Publisher: name: Università degli Studi di Napoli Federico II
Year: 2015

description: Nel presente lavoro di tesi sono stati studiati i fenomeni diffusivi di vapori in polimeri amorfi e semicristallini utilizzando come tecnica di analisi la spettroscopia FTIR in risoluzione temporale. L'attenzione si è focalizzata sui sistemi poliesteri (PCL, PPSeb)/ acqua e poliimmidi (6FDA-ODA, PMDA-ODA, Ultem®1000)/ metanolo.
La tecnica FTIR in risoluzione temporale ha consentito di individuare il sito/i di interazione del penetrante con la matrice e di interpretare le interazioni molecolari che si instaurano tra le sostanze a basso peso molecolare e il polimero. L'accoppiamento tra il dato spettroscopico e quello gravimetrico ha permesso di ricavare l'assorbività molare e quindi la concentrazione delle diverse specie molecolari presenti nei sistemi analizzati, mettendo in evidenza il ruolo dell'interazione legame-idrogeno. Ulteriori informazioni sulla natura delle specie presenti nei sistemi sono state ottenute analizzando i dati con tecniche complementari, quali la sottrazione spettrale e la spettroscopia bidimensionale di correlazione (2D-COS).
Infine, parte della tesi ha riguardato lo studio di un polimero amorfo, e, in particolare, la diffusione e la contemporanea co-cristallizzazione indotta dai vapori di benzene nel polifenilenossido (PPO) dimostrando che il processo di cristallizzazione s'innesca nel momento in cui il sistema abbia assorbito una concentrazione critica di benzene, restando allo stato amorfo a valori di concentrazione inferiori.
Leveraging Analog Quantum Computing with Neutral Atoms for Solvent Configuration Prediction in Drug Discovery
Creators: name: D'Arcangelo, Mauro
name: Loco, Daniele
name: team, Fresnel
name: Gouraud, Nicolaï
name: Angebault, Stanislas
name: Sueiro, Jules
name: Monmarché, Pierre
name: Forêt, Jérôme
name: Henry, Louis-Paul
name: Henriet, Loïc
name: Piquemal, Jean-Philip
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: We introduce quantum algorithms able to sample equilibrium water solvent molecules configurations within proteins thanks to analog quantum computing. To do so, we combine a quantum placement strategy to the 3D Reference Interaction Site Model (3D-RISM), an approach capable of predicting continuous solvent distributions. The intrinsic quantum nature of such coupling guarantees molecules not to be placed too close to each other, a constraint usually imposed by hand in classical approaches. We present first a full quantum adiabatic evolution model that uses a local Rydberg Hamiltonian to cast the general problem into an anti-ferromagnetic Ising model. Its solution, an NP-hard problem in classical computing, is embodied into a Rydberg atom array Quantum Processing Unit (QPU). Following a classical emulator implementation, a QPU portage allows to experimentally validate the algorithm performances on an actual quantum computer. As a perspective of use on next generation devices, we emulate a second hybrid quantum-classical version of the algorithm. Such a variational quantum approach (VQA) uses a classical Bayesian minimization routine to find the optimal laser parameters. Overall, these Quantum-3D-RISM (Q-3D-RISM) algorithms open a new route towards the application of analog quantum computing in molecular modelling and drug design.
Similarities Between Classical Timelike Geodesics in a Naked Reissner-Nordstrom Singularity Background and the Behaviour of Electrons in Quantum Theory
Creators: name: Qadir, Asghar
name: Siddiqui, Azad A.
Publisher: name: arXiv
Year: 2006
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: It is generally assumed that naked singularities must be physically excluded, as they could otherwise introduce unpredictable influences in their future null cones. Considering geodesics for a naked Reissner-Nordstrom singularity, it is found that the singularity is effectively clothed by its repulsive nature. Regarding electron as naked singularity, the size of the clothed singularity (electron) turns out to be classical electro-magnetic radius of the electron, to an observer falling freely from infinity, initially at rest. The size shrinks for an observer falling freely from infinity, with a positive initial velocity. For geodetic parameters corresponding to negative energy there are trapped geodesics. The similarity of this picture with that arising in the Quantum Theory is discussed.
description: 8 pages, 6 figures
Innovative Virtual Air Data Sensors: Algorithms and Flight Test Results
Creators: name: Garbarino, Luca
Publisher: name: Università degli Studi di Napoli Federico II
Year: 2015

description: This thesis deals with the design, prototype implementation and the assessment of virtual sensors for an Air Data System (ADS). The needs for the development of a virtual Air Data Sensors resides on two relevant aspects in aviation transport development: a) the opportunity to improve the safety of manned aviation, by implementing an affordable solution for ADS redundancy; b) the possibility to improve the reliability of unmanned air vehicles (UAVs), which can support their integration in non-segregated airspace.
Virtual sensors are normally considered as a relevant component of Fault Detection and Isolation approaches to the Fault Tolerant Control Theory, briefly introduced in the thesis.
Virtual sensors for both the Angle-of-Attack and the Indicated Air Speed have been developed and completely assessed in CIRA Laboratory test bed for Real-Time Simulation with Hardware and Pilot-in-the-Loop.
In some cases, the assessment has also been achieved in flight test, on the FLARE vehicle which CIRA operates specifically for the execution of flight test of prototype technologies.
The thesis first analyses and describe the basic methodologies for the virtual sensors design, identifying those better suitable for application to air data measures. In particular, both the model-based technique and the implementation of ADS Virtual Sensors through Artificial Neural Networks are described. Special attention is given to the data selection techniques aimed at network training and assessment, focusing the machine learning approach to this aspects.
The study case applied to the TECNAM P92 VLA vehicle is described in detail, posing attention to the description of both the laboratory set-up realization and to the specific upgrades which have been required to the TECNAM P92 vehicle for the in-flight tests of the developed virtual sensors.
The assessment of both the model-based Virtual Sensors and the ANN Virtual Sensors is finally documented.
Space-based Measurements of Neutron Lifetime: Approaches to Resolving the Neutron Lifetime Anomaly
Creators: name: Lawrence, David J.
name: Wilson, Jack T.
name: Peplowski, Patrick N.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Free neutrons have a measured lifetime of 880 s, but disagreement between existing laboratory measurements of ~10 s have persisted over many years. This uncertainty has implications for multiple physics disciplines, including standard-model particle physics and Big-Bang nucleosynthesis. Space-based neutron lifetime measurements have been shown to be feasible using existing data taken at Venus and the Moon, although the uncertainties for these measurements of tens of seconds prevent addressing the current lifetime discrepancy. We investigate the implementation of a dedicated space-based experiment that could provide a competitive and independent lifetime measurement. We considered a variety of scenarios, including measurements made from orbit about the Earth, Moon, and Venus, as well as on the surface of the Moon. For a standard-sized neutron detector, a measurement with three-second statistical precision can be obtained from Venus orbit in less than a day; a one-second statistical precision can be obtained from Venus orbit in less than a week. Similarly precise measurements in Earth orbit and on the lunar surface can be acquired in less than 40 days (three-second precision) and ~300 days (one-second precision). Systematic uncertainties that affect a space-based neutron lifetime measurement are investigated, and the feasibility of developing such an experiment is discussed.
description: 33 pages; 9 figures; submitted to Nuclear Instruments and Methods in Physics Research, A
Vulnerabilidade e resiliência - A humanização em Cuidados Paliativos como fator facilitador da ressignificação da vida diante da adversidade
Creators: name: Alves de Oliveira, João Batista
Publisher: name: Zenodo
Year: 2024
Subjects: Vulnerabilidade. Resiliência. Qualidade de vida. Cuidado Paliativo

description: A vulnerabilidade é uma constante nos pacientes em Cuidado Paliativo, não só pela doença física em si, mas pela dor total (física, psíquica, social e espiritual) que impacta em maior ou menor grau, dependendo da sua capacidade de ser ou não resiliente. Por isso é importante entendermos a vulnerabilidade e a resiliência desses pacientes para que possamos contribuir para sua melhor qualidade de vida, ajudando-os a construir sobre a adversidade por meio de uma adaptação positiva

 

Não havendo abordagem de condutas, não há necessidade de isenção de responsabilidade
Antoniazzo Romano
Creators: name: Russo, Giovanni
Publisher: name: Università degli Studi di Napoli Federico II
Year: 2015

description: La tesi è il catalogo del pittore, preceduto da quattro saggi relativi alla fortuna negli studi, alla biografia (con regesto documentario), all'esame dello stile, e alla specifica attività di copista sacro. Il catalogo si compone delle sezioni relative alle opere di Antoniazzo e della bottega, a quelle perdute, e a un ristretto numero di espunzioni. Segue l'apparato illustrativo.
Translation to Bundle Operators
Creators: name: Branson, Thomas P.
name: Hong, Doojin
Publisher: name: arXiv
Year: 2006
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53C50

description: We give explicit formulas for conformally invariant operators with leading term an $m$-th power of Laplacian on the product of spheres with the natural pseudo-Riemannian product metric for all $m$.
description: This is a contribution to the Proceedings of the 2007 Midwest Geometry Conference in honor of Thomas P. Branson, published in SIGMA (Symmetry, Integrability and Geometry: Methods and Applications) at http://www.emis.de/journals/SIGMA/
Exact black hole solutions in higher-order scalar-tensor theories
Creators: name: Babichev, Eugeny
name: Charmousis, Christos
name: Lecoeur, Nicolas
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this chapter, we discuss explicit black hole solutions in higher-order scalar-tensor theories. After a brief recap of no-hair theorems, we start our discussion by so-called stealth solutions present in theories with parity and shift symmetry. Stealth solutions are such that their metric are Ricci flat General Relativity solutions, but they are accompanied by a non-trivial scalar field, in both spherically-symmetric and rotating cases. The stealth metrics then enable to construct an analytic stationary solution of scalar-tensor theory which is called disformed Kerr metric. This solution constitutes a measurable departure from the usual Kerr geometry of GR. We discuss within parity and shift symmetric theories several non-stealth solutions. We then consider scalar-tensor theories stemming from a Kaluza-Klein reduction of a higher-dimensional Lovelock theory. These theories encompass all Horndeski functionals and hence go beyond parity and shift symmetry. Reduction and singular limits allow one to obtain non-stealth black holes with differing interesting properties which are not Ricci flat metrics. We analyse the solutions obtained and classify them with respect to the geometry of the internal space according to their Kaluza-Klein origin.
description: Lecture Notes in Physics from the 11th Aegean summer school "Recent developments in theory and observations in gravity and cosmology". No figures, 35 pages
Extensive Immunoinformatics study for the prediction of novel peptide-based epitope vaccine with docking confirmation against Envelope protein of Chikungunya virus: A Computational Biology Approach
Creators: name: Bappy, Syed Shahariar
name: Sorna Sultana
name: Juthi Adhikari
name: Shafi Mahmud
name: Md. Arif Khan
name: K. M. Kaderi Kibria
name: Md. Masuder Rahman
name: Shibly, Abu Zaffar
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Background: Chikungunya virus (CHIKV) instigating Chikungunya fever is a global infective menace resulting in high fever, weakened joint-muscle pain, and brain inflammation. Inaccessibility and unavailability of effective drugs have led us to an uncertain arena when it comes to providing proper medical treatment to the affected people. Method: In this study, authentic encroachment has been made concerning the peptide-based epitope vaccine designing against CHIKV. A Proteome-wide search was performed to locate a conserved portion among the accessible viral outer membrane proteins which showcase a remarkable immune response using specific immunoinformatics and docking simulation tools. Results: Primarily, the most probable immunogenic envelope glycoproteins E1 and E2 were identified from the UniProt database depending on their antigenicity scores. Subsequently, we selected two distinctive sequences “SEDVYANTQLVLQRP” and “IMLLYPDHPTLLSYR” in both E1 and E2 glycoproteins respectively. These two sequences identified as the most potent T and B cell epitope-based peptides as they interacted with 6 and 7 HLA-I and 5 HLA-II molecules with an extremely low IC50 score that was verified by molecular docking. Moreover, the sequences possess no allergenicity and are certainly located outside the transmembrane region. In addition, the sequences exhibited 88.46% and 100.00% Conservancy, covering high population coverage of 89.49% to 94.74% and 60.51% to 88.87% respectively in endemic countries. Conclusion: The identified peptide SEDVYANTQLVLQRP and IMLLYPDHPTLLSYR can be utilized next for the development of peptide-based epitope vaccine contrary to CHIKV, So further documentations and experimentations like Antigen testing, Antigen production, Clinical trials are needed to prove the validity of it.
Laws of large numbers for epidemic models with countably many types
Creators: name: Barbour, A. D.
name: Luczak, M. J.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 92D30, 60J27, 60B12 (Primary)

description: In modeling parasitic diseases, it is natural to distinguish hosts according to the number of parasites that they carry, leading to a countably infinite type space. Proving the analogue of the deterministic equations, used in models with finitely many types as a "law of large numbers" approximation to the underlying stochastic model, has previously either been done case by case, using some special structure, or else not attempted. In this paper we prove a general theorem of this sort, and complement it with a rate of convergence in the $\ell_1$-norm.
description: Published in at http://dx.doi.org/10.1214/08-AAP521 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Discovery of small molecule inhibitors of chikungunya virus proteins (nsP2 and E1) using in silico approaches
Creators: name: Naushad Khan
name: Bhat, Ruchika
name: Patel, Ashok K.
name: Ray, Pratima
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Chikungunya virus (CHIKV) has emerged as a major viral threat, affecting over a million people worldwide per year. It is a vector borne disease transmitted to the human by Ades mosquitoes and primarily affect people by causing viral fever, severe joint pain and other symptoms, like rash, joint swelling, muscle pain and in rare cases can be fatal. CHIKV is a deadly virus, with its mutation rate found to be significantly higher as compared to other viruses. To date, there has been no reported FDA approved drug against this virus. Thus, keeping in mind the urgent need to scrutinize potential therapies against CHIKV, the present study identified twenty plant bioactive compounds that are available at low price and do not have associated adverse effect. For identification of active potentials molecules the pharmacoinformatics-based perspective was applied against CHIKV structural (E1) and non-structural (nsP2) proteins using molecular docking and scoring. The selected compounds were further studied for pharmacokinetics (PK) and pharmacodynamics (PD) associated parameters such as initial absorption, then distribution and later on metabolism excretion and toxicity (ADMET) profiles based on in silico study. The results reveal five potential lead compounds having high binding energy that can help in the development of commercial drugs with favorable ADMET characteristic. Communicated by Ramaswamy H. Sarma
Spin Weyl Topological Insulators
Creators: name: Gonzalez-Hernandez, Rafael
name: Uribe, Bernardo
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Algebraic Topology (math.AT)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: The quantum nature of electron spin is crucial for establishing topological invariants in real materials. Since the spin does not in general commute with the Hamiltonian, some of the topological features of the material can be extracted from its study. In insulating materials, the spin operator induces a projected operator on valence states called the spin valence operator. Its spectrum contains information with regard to the different phases of the spin Chern class. If the spin valence spectrum is gapped, the spin Chern numbers are constant along parallel planes thus defining spin Chern insulating materials. If the spin valence spectrum is not gapped, the changes in the spin Chern numbers occur whenever this spectrum is zero. Materials whose spin valence spectrum is gapless will be denoted spin Weyl topological insulators and their definition together with some of their properties will be presented in this work. The classification of materials from the properties of the spin valence operator provides a characterization that complements the existing list of topological invariants.
description: 12 pages, 6 figures
Understanding farmers’ barriers to health and mental health-related help-seeking: The development, factor structure, and reliability of the Farmer Help-Seeking Scale
Creators: name: Skaczkowski, Gemma
name: Hull, M
name: Smith, AE
name: Dollman, J
name: Jones, Martin
name: Gunn, KM
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 4404
subject: Development studies
classificationCode: 4203
subject: Health services and systems
classificationCode: 4206
subject: Public health

description: Purpose: The aim of this research was to develop a contextually and culturally appropriate scale to assess farmers’ barriers to health-related help-seeking. Methods: An initial pool of items was developed from the academic literature and input from an expert panel of farmers, rural academics, and rural clinicians. A draft 32-item questionnaire was then developed and sent to farmers registered with FARMbase, which is an Australian national farmer database. Findings: Two hundred and seventy-four farmers completed the draft questionnaire (93.7% male, 73.7% aged 56-75 years). An exploratory factor analysis identified 6 factors; “Health Issues are a Low Priority,” “Concerns about Stigma,” “Structural Health System Barriers,” “Minimization and Normalization,” “Communication Barriers,” and “Continuity of Care.”. Test-retest reliability was examined with a further 10 farmers (90% male, Mean age = 57, SD = 5.91), who completed the questionnaire twice (at 2- to 3-week intervals). Results indicated moderate-good test-retest reliability. Conclusions: The resulting 24-item Farmer Help-Seeking Scale provides a measure of help-seeking that is specifically designed to capture the unique context, culture, and attitudes that can interfere with farmers’ help-seeking, and inform the development of strategies to increase health-service utilization in this at-risk group.
Hecke algebras of finite type are cellular
Creators: name: Geck, Meinolf
Publisher: name: arXiv
Year: 2006
Subjects: subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 20C08

description: Let $\cH$ be the one-parameter Hecke algebra associated to a finite Weyl group $W$, defined over a ground ring in which ``bad'' primes for $W$ are invertible. Using deep properties of the Kazhdan--Lusztig basis of $\cH$ and Lusztig's $\ba$-function, we show that $\cH$ has a natural cellular structure in the sense of Graham and Lehrer. Thus, we obtain a general theory of ``Specht modules'' for Hecke algebras of finite type. Previously, a general cellular structure was only known to exist in types $A_n$ and $B_n$.
description: 14 pages; added references
Influence of the ice structure on the soft UV photochemistry of PAHs embedded in solid water
Creators: name: Noble, J. A.
name: Michoulier, E.
name: Aupetit, C.
name: Mascetti, J.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The UV photoreactivity of polycyclic aromatic hydrocarbons (PAHs) in porous amorphous solid water has long been known to form both oxygenated photoproducts and photofragments. The aim of this study was to examine the influence of the ice structure upon reactivity under soft UV irradiation conditions. Mixtures of PAHs with amorphous solid water (porous and compact) and crystalline (cubic and hexagonal) ices were prepared in a high vacuum chamber and irradiated using a mercury lamp for up to 2.5 hours. The results show that the production of oxygenated PAHs is efficient only in amorphous water ice, while fragmentation can occur in both amorphous and crystalline ices. We conclude that the reactivity is driven by PAH-water interactions in favourable geometries, notably where dangling bonds are available at the surface of pores. These results suggest that the formation of oxygenated PAH molecules is most likely to occur in interstellar environments with porous (or compact) amorphous solid water and that this reactivity could considerably influence the inventory of aromatics in meteorites.
description: Accepted for publication in A&A
Enhanced metastable state models of TAM kinase binding to cabozantinib explains the dynamic nature of receptor tyrosine kinases
Creators: name: Gatta K R S Naresh
name: Guruprasad, Lalitha
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 60506 Virology
subject: Computational Biology

description: Receptor tyrosine kinases (RTKs) are essential proteins in the regulation of cell signaling. Tyro3, Axl and Mer are members of TAM RTKs and are overexpressed in several cancer forms. Kinase inhibitors such as cabozantinib, foretinib are reported to inhibit TAM kinases at nanomolar concentrations. The atomistic details of structure and mechanism of functional regulation is required to understand their normal physiological process and when bound to an inhibitor. The docking of cabozantinib into the active state conformations of TAM kinases (crystal structure and computational models) revealed the best binding pose and the complex formation that is mediated through non-bonding interactions involving the hinge region residues. The alterations in the conformations and the regions of flexibility in apo and complexed TAM kinases as a course of time are studied using 250 ns molecular dynamics (MD) simulations. The post-MD trajectory analysis using Python libraries like ProDy, MDTraj and PyEMMA revealed encrypted protein dynamic motions in active kinetic metastable states. Comparison between Principal component analysis and Anisotropic mode analysis deciphered structural residue interactions and salt bridge contacts between apo and inhibitor bound TAM kinases. Various structural changes occurred in αC-helix and activation loop involving hydrogen bonding between residues from Lys-(β3 sheet), Glu-(αC-helix) and Asp-(DFG-motif) resulting in higher RMSD. Mechanical stiffness plots revealed that similar regions in apo and cabozantinib bound Axl fluctuated during MD simulations whereas different regions in Tyro3 and Mer kinases. The residue interaction network plots revealed important salt bridges that lead to constrained domain motions in the TAM kinases.
Congenital and aquired myopathies in dogs: case series
Creators: name: Napoleone, Giusy
Publisher: name: Università degli Studi di Napoli Federico II
Year: 2015

description: Diseases affecting muscles and the neuromuscular junction are commonly overlooked when evaluating a dog with lameness. Orthopedic disorders occur more frequently than neuromuscular disorders; however, when a diagnosis cannot be reached following a careful orthopedic evaluation, neuromuscular pathologic conditions should be considered. Affected individuals with muscle or neuromuscular junction disease may present with lameness, limb contractures or more generalized musculoskeletal abnormalities, such as a crouched stance and stiff, short-stridden gait. In veterinary clinical practice, the simplest and most routine diagnostic test for muscle disease is blood chemistry. When available, muscle biopsy remains the most useful diagnostic tool in the diagnosis of muscle disease, both in human and in veterinary medicine. As in human medicine, in animals EMG studies represent the state of the art in neuromuscular diagnostic techniques.
This is a retrospective study in which we evaluate all the cases of myopathies referred  to the Department of Veterinary Medicine and Animal Productions of the University of Napoli Federico II from 2004 to 2014.
Atomic-scale modeling of the effect of lipid peroxidation on the permeability of reactive species
Creators: name: Surendra Kumar
name: Rana, Rashmi
name: Dharmendra K. Yadav
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Computational Biology

description: Biomembranes and lipid systems are rich in unsaturated lipid components and are subject to photo-induced lipid peroxidation. The peroxidized lipid products in cellular systems are known to affect the structural organization and function of the biomembrane. We employed molecular dynamics simulations to study the effects of phospholipid peroxidation on membrane properties and the permeability of different reactive species. The results suggest that when the lipids are peroxidized, the peroxide group moves toward the membrane surface, which causes the membrane system to expand laterally and increase in area. The permeability profile revealed that nitrogen species can easily permeate through the native and peroxidized system in comparison to oxygen species, suggesting its importance in plasma-based treatment. Thus, by breaching the energy barrier with lower energy, they can traverse the cell membrane and induce oxidative stress, which leads to apoptosis.
Vulnerabilidad y resiliencia - La humanización en Cuidados Paliativos como factor facilitador de la resignificación de la vida ante la adversidad
Creators: name: Alves de Oliveira, João Batista
Publisher: name: Zenodo
Year: 2024
Subjects: Vulnerabilidad. Resiliencia. Calidad de vida . Cuidados Paliativos

description: La vulnerabilidad es una constante en los pacientes de Cuidados Paliativos, no sólo por la enfermedad física en sí, sino por el dolor total (físico, psicológico, social y espiritual) que impacta en los pacientes en mayor o menor grado, dependiendo de su capacidad para ser resilientes o no. Por eso es importante entender la vulnerabilidad y la resiliencia de estos pacientes para poder contribuir a su mejor calidad de vida, ayudándoles a superar la adversidad mediante una adaptación positiva
Hansenocaris undetermined
Creators: name: Olesen, Jørgen
name: Grygier, Mark J.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Maxillopoda
Hansenocarididae
Hansenocaris
Hansenocaris undetermined

description: Y-nauplius Type X
Figs 2, 13A–E
Type X – Dreyer et al. 2023a: figs 4, 5a, c, tables s1–s2. — Olesen et al. 2024: fig. 3d–e.
En levende nauplius-y – Høeg 2005: 18, unnumbered LM photograph.
Not Type X – Itô 1987a: 913, 916–917, fig. 2a. — Kikuchi et al. 1991: 69, 72–73, tables 1, 3, fig. 2b. — Watanabe et al. 2000: 7, 9, fig. 5. — Kolbasov & Høeg 2003: 3, 13.
Material examined
JAPAN – Okinawa, Sesoko I., laboratory pier, 26°38ʹ09.4ʺ N, 127°51ʹ55.2ʺ E • 1 LSN; 1991–2005 • 9 LSN, 3 of which molted to cyprids; 2018–2019 (Tables 1 and S1).
Description
LAST-STAGE NAUPLIUS (LSN). Lecithotrophic. Body elongate-ovate in dorso-vental view, i.e., racket- or snowshoe-shaped, about 1.7 times as long as wide (excluding dorso-caudal spine); cephalic shield ovate/ellipsoidal, with no discontinuity in lateral body outline between shield and trunk. In lateral view, longitudinal axes of cephalon, trunk and dorso-caudal spine all approximately in same plane. Length 330–360 µm (ventral view in life, without dorso-caudal spine), greatest width ca 220 µm, dorso-ventral thickness not measured. Labrum produced as low, nearly square elevation, posterior two-thirds of which trapezoidal owing to lateral insertions of first and second antennae; surface weakly divided into facets by cuticular ridges; pore pattern not studied in detail. Caudal end attenuate/acuminate, terminating without marked discontinuity in broad-based ca 100 µm long, multi-annulate and heavily spinose dorso-caudal spine accompanied ventrally by pair of triangular furcal spines ca 10 µm long.
CYPRID VIEWED THROUGH CUTICLE OF LSN. Body overall transparent but with brownish pigmentation appearing later in LSN phase. In early-phase LSN, lateral margins of cyprid’s cephalon with clusters of crystal-like particles and gut-like tube packed with brown/white yolk granules, those in telson being orange in some specimens. Telson about as wide as long and half as long as thorax during early phase of LSN, becoming more elongate later.
Identification and variation
Easily recognizable by its large size and snowshoe- or racket-shaped body. Little variation is apparent among LSN specimens.
Distribution
Japan (Sesoko Island, Okinawa).
description: Published as part of Olesen, Jørgen & Grygier, Mark J., 2024, Taxonomic diversity of marine planktonic ' y-larvae' (Crustacea: Facetotecta) from a coral reef hotspot locality (Japan, Okinawa), with a key to y-nauplii, pp. 1-90 in European Journal of Taxonomy 929 (1) on pages 34-35, DOI: 10.5852/ejt.2024.929.2479, http://zenodo.org/record/10876286
Classification of Classical Spin Liquids: Topological Quantum Chemistry and Crystalline Symmetry
Creators: name: Fang, Yuan
name: Cano, Jennifer
name: Nevidomskyy, Andriy H.
name: Yan, Han
Publisher: name: arXiv
Year: 2023
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Frustrated magnetic systems can host highly interesting phases known as classical spin liquids (CSLs), which feature {extensive} ground state degeneracy and lack long-range magnetic order. Recently, Yan and Benton et al. proposed a classification scheme of CSLs in the large-$\mathcal{N}$ (soft spin) limit [arXiv.2305.00155], [arXiv:2305.19189]. This scheme classifies CSLs into two categories: the algebraic CSLs and the fragile topological CSLs, each with their own correlation properties, low energy effective description, and finer classification frameworks. In this work, we further develop the classification scheme by considering the role of crystalline symmetry. We present a mathematical framework for computing the band representation of the flat bands in the spectrum of these CSLs, which extends beyond the conventional representation analysis. It allows one to determine whether the algebraic CSLs, which features gapless points on their bottom flat bands, are protected by symmetry or not. It also provides more information on the finer classifications of algebraic and fragile topological CSLs. We demonstrate this framework via concrete examples and showcase its power by constructing a pinch-line algebraic CSL protected by symmetry.
description: 12 pages, 4 pages. Third paper in the series of [arXiv.2305.00155], [arXiv:2305.19189]
Robust Energy-Efficient Resource Management, SIC Ordering, and Beamforming Design for MC MISO-NOMA Enabled 6G
Creators: name: Zakeri, Abolfazl
name: Khalili, Ata
name: Javan, Mohammad Reza
name: Mokari, Nader
name: Jorswieck, Eduard A
Publisher: name: arXiv
Year: 2021
Subjects: subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This paper studies a novel approach for successive interference cancellation (SIC) ordering and beamforming in a multiple antennas non-orthogonal multiple access (NOMA) network with multi-carrier multi-user setup. To this end, we formulate a joint beamforming design, subcarrier allocation, user association, and SIC ordering algorithm to maximize the worst-case energy efficiency (EE). The formulated problem is a non-convex mixed integer non-linear programming (MINLP) which is generally difficult to solve. To handle it, we first adopt the linearizion technique as well as relaxing the integer variables, and then we employ the Dinkelbach algorithm to convert it into a more mathematically tractable form. The adopted non-convex optimization problem is transformed into an equivalent rank-constrained semidefinite programming (SDP) and is solved by SDP relaxation and exploiting sequential fractional programming. Furthermore, to strike a balance between complexity and performance, a low complex approach based on alternative optimization is adopted. Numerical results unveil that the proposed SIC ordering method outperforms the conventional existing works addressed in the literature.
description: Major Revision by IEEE TSP
Anti-dengue infectivity evaluation of bioflavonoid from Azadirachta indica by dengue virus serine protease inhibition
Creators: name: Dwivedi, Vivek Dhar
name: Bharadwaj, Shiv
name: Sumbul Afroz
name: Nooruddin Khan
name: Mairaj Ahmed Ansari
name: Yadava, Umesh
name: Tripathi, Ramesh Chandra
name: Tripathi, Indra Prasad
name: Sarad Kumar Mishra
name: Kang, Sang Gu
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Dengue virus (DENV) serine protease enzyme, i.e. NS2B-NS3pro (non-structural protein 2B-non-structural protein 3) has been approved as prime drug target for the drug discovery against dengue infection, because of its essential role in viral replication. This study demonstrates the potential of bioflavonoids from Azadirachta indica against dengue infection using computational and experimental approach. Initially, 49 bioflavonoids reported in Azadirachta indica were collected and virtually screened on the catalytic triad of DENV protease, results in the identification of kaempferol-3-O-rutinoside (−9.555 kcal/mol), rutin (−9.324 kcal/mol), hyperoside (−7.879 kcal/mol), and epicatechin (−7.622 kcal/mol) as potent viral protease inhibitors against reference compound quercetin (−6.94 kcal/mol). Subsequently, these docked complexes were analyzed for the stability via molecular dynamics simulations and free binding energy calculations, suggested the considerable stability of selected bioflavonoids with viral protease. Additionally, density functional theory and ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) analysis indicated the least chemical reactivity and considerable medicinal properties, respectively for the screened bioflavonoids by comparison to quercetin. Accordingly, kaempferol 3-O-β-rutinoside and epicatechin were evaluated at various concentrations for cell viability (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay) and in vitro antiviral activity (focus forming unit assay) against DENV-2 strain. The antiviral assay showed dose dependent inhibition of DENV-2 infectivity by the selected compounds while maximum 77.7% and 66.2% viral inhibition were recorded for 100 µM kaempferol 3-O-β-rutinoside and 1000 µM epicatechin, respectively without significant cell toxicity. These results suggested the potential of bioflavonoids from Azadirachta indica in the development of effective drug against dengue infection. Communicated by Ramaswamy H. Sarma
Order selection for same-realization predictions in autoregressive processes
Creators: name: Ing, Ching-Kang
name: Wei, Ching-Zong
Publisher: name: arXiv
Year: 2006
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics
subject: 60M20 (Primary) 62M10 (Secondary)

description: Assume that observations are generated from an infinite-order autoregressive [AR($\infty$)] process. Shibata [Ann. Statist. 8 (1980) 147--164] considered the problem of choosing a finite-order AR model, allowing the order to become infinite as the number of observations does in order to obtain a better approximation. He showed that, for the purpose of predicting the future of an independent replicate, Akaike's information criterion (AIC) and its variants are asymptotically efficient. Although Shibata's concept of asymptotic efficiency has been widely accepted in the literature, it is not a natural property for time series analysis. This is because when new observations of a time series become available, they are not independent of the previous data. To overcome this difficulty, in this paper we focus on order selection for forecasting the future of an observed time series, referred to as same-realization prediction. We present the first theoretical verification that AIC and its variants are still asymptotically efficient (in the sense defined in Section 4) for same-realization predictions. To obtain this result, a technical condition, easily met in common practice, is introduced to simplify the complicated dependent structures among the selected orders, estimated parameters and future observations. In addition, a simulation study is conducted to illustrate the practical implications of AIC. This study shows that AIC also yields a satisfactory same-realization prediction in finite samples. On the other hand, a limitation of AIC in same-realization settings is pointed out. It is interesting to note that this limitation of AIC does not exist for corresponding independent cases.
description: Published at http://dx.doi.org/10.1214/009053605000000525 in the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Classification of Magnetic Vortices by Angular Momentum Conservation
Creators: name: Fukushima, Kenji
name: Hidaka, Yoshimasa
name: Yee, Ho-Ung
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Superfluid vortices are quantum excitations carrying quantized amount of orbital angular momentum in a phase where global symmetry is spontaneously broken. We address a question of whether magnetic vortices in superconductors with dynamical gauge fields can carry nonzero orbital angular momentum or not. We discuss the angular momentum conservation in several distinct classes of examples from crossdisciplinary fields of physics across condensed matter, dense nuclear systems, and cosmology. The angular momentum carried by gauge field configurations around the magnetic vortex plays a crucial role in satisfying the principle of the conservation law. Based on various ways how the angular momentum conservation is realized, we provide a general scheme of classifying magnetic vortices in different phases of matter.
description: 35 pages, 5 figures
Observing with a space-borne gamma-ray telescope: selected results from INTEGRAL
Creators: name: Schanne, S.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The International Gamma-Ray Astrophysics Laboratory, i.e. the INTEGRAL satellite of ESA, in orbit since about 3 years, performs gamma-ray observations of the sky in the 15 keV to 8 MeV energy range. Thanks to its imager IBIS, and in particular the ISGRI detection plane based on 16384 CdTe pixels, it achieves an excellent angular resolution (12 arcmin) for point source studies with good continuum spectrum sensitivity. Thanks to its spectrometer SPI, based on 19 germanium detectors maintained at 85 K by a cryogenic system, located inside an active BGO veto shield, it achieves excellent spectral resolution of about 2 keV for 1 MeV photons, which permits astrophysical gamma-ray line studies with good narrow-line sensitivity. In this paper we review some goals of gamma-ray astronomy from space and present the INTEGRAL satellite, in particular its instruments ISGRI and SPI. Ground and in-flight calibration results from SPI are presented, before presenting some selected astrophysical results from INTEGRAL. In particular results on point source searches are presented, followed by results on nuclear astrophysics, exemplified by the study of the 1809 keV gamma-ray line from radioactive 26Al nuclei produced by the ongoing stellar nucleosynthesis in the Galaxy. Finally a review on the study of the positron-electron annihilation in the Galactic center region, producing 511 keV gamma-rays, is presented.
description: Invited talk at the NPDC19 Conference of the European Physical Society, Pavia, September 2005. Published in the IoP J. Phys. (2006) Conf. Ser. 41 46-60
Teach AI How to Code: Using Large Language Models as Teachable Agents for Programming Education
Creators: name: Jin, Hyoungwook
name: Lee, Seonghee
name: Shin, Hyungyu
name: Kim, Juho
Publisher: name: arXiv
Year: 2023
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: This work investigates large language models (LLMs) as teachable agents for learning by teaching (LBT). LBT with teachable agents helps learners identify knowledge gaps and discover new knowledge. However, teachable agents require expensive programming of subject-specific knowledge. While LLMs as teachable agents can reduce the cost, LLMs' expansive knowledge as tutees discourages learners from teaching. We propose a prompting pipeline that restrains LLMs' knowledge and makes them initiate "why" and "how" questions for effective knowledge-building. We combined these techniques into TeachYou, an LBT environment for algorithm learning, and AlgoBo, an LLM-based tutee chatbot that can simulate misconceptions and unawareness prescribed in its knowledge state. Our technical evaluation confirmed that our prompting pipeline can effectively configure AlgoBo's problem-solving performance. Through a between-subject study with 40 algorithm novices, we also observed that AlgoBo's questions led to knowledge-dense conversations (effect size=0.71). Lastly, we discuss design implications, cost-efficiency, and personalization of LLM-based teachable agents.
Density-constrained time-dependent Hartree-Fock calculation of $^{16}$O+$^{208}$Pb fusion cross sections
Creators: name: Umar, A. S.
name: Oberacker, V. E.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We present a fully microscopic study of the $^{16}$O+$^{208}$Pb fusion using the density-constrained time-dependent Hartree-Fock theory. The calculated fusion cross-sections are in good agreement with the experimental data for the entire energy range indicating that the incorporation of dynamical effects is crucial in describing heavy-ion fusion.
description: 5 pages, 3 figures
A New Approach to the Optimal Target Selection Problem
Creators: name: Elson, E. C.
name: Bassett, B. A.
name: van der Heyden, K.
name: Vilakazi, Z. Z.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Astrophysics (astro-ph)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: Optimally selecting a subset of targets from a larger catalog is a common problem in astronomy and cosmology. A specific example is the selection of targets from an imaging survey for multi-object spectrographic follow-up. We present a new heuristic algorithm, HYBRID, for this purpose and undertake detailed studies of its performance. HYBRID combines elements of the simulated annealing, MCMC and particle-swarm methods and is particularly successful in cases where the survey landscape has multiple curvature or clustering scales. HYBRID consistently outperforms the other methods, especially in high-dimensionality spaces with many extrema. This means many fewer simulations must be run to reach a given performance confidence level and implies very significant advantages in solving complex or computationally expensive optimisation problems.
description: 10 pages, 14 figures, Extended version accepted to Astron. Astrophys