cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MOESM6 of A synergic effect between CYP2C19*2, CYP2C19*3 loss-of-function and CYP2C19*17 gain-of-function alleles is associated with Clopidogrel resistance among Moroccan Acute Coronary Syndromes patients
Creators: name: Idrissi, Hind Hassani
name: Wiam Hmimech
name: Khorb, Nada
name: Akoudad, Hafid
name: Habbal, Rachida
name: Sellama Nadifi
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: Computational Biology

description: Additional file 1: Table S1. Demographic data of the 75 ACS patients.
Oxaliplatin-loaded nanoemulsion containing Teucrium polium L. essential oil induces apoptosis in Colon cancer cell lines through ROS-mediated pathway
Creators: name: Al-Otaibi, Waad A.
name: AlMotwaa, Sahar M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Cell Biology
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology

description: Oxaliplatin (Oxa)-associated adverse side effects have considerably limited the clinical use of the drug in colon cancer therapy. Mutant p53 has diverse mutational profiles in colon cancer, and it influences the potencies of various chemotherapeutic drugs, including Oxa. Thus, it would be highly beneficial to identify an alternative therapeutic strategy that not only reduces the toxicity of Oxa, but also exerts a synergistic effect against colon cancers, regardless of their p53 profiles. The present study was aimed at preparing and optimizing Teucrium polium L. essential oil nanoemulsion (TPO-NANO) and investigating its effect on the sensitivity of colon cancer cells with differences in p53 status (HCT116 wild-type and HT-29 mutant-type) to Oxa. The viability of treated cells was determined and the combination index (CI) was calculated. Morphological changes were determined under inverted microscopy, while percentage apoptosis was assayed using flow cytometry. Intracellular ROS and the protein levels of p53 and Bax were measured. The colony-forming potential of treated cells was determined using colony assay. The size of TPO-NANO was markedly increased from 12.90 ± 0.04 nm to 14.47 ± 0.53 nm after loading Oxa (p ≤ 0.05). The combination (Oxa + TPO-NANO) produced a synergetic effect in HCT116 and HT-29, with CI of 0.94 and 0.88, respectively. Microscopic examination and flow cytometric analysis revealed that cells treated with Oxa + TPO-NANO had a higher percentage of apoptosis than cells exposed to monotherapy. Cumulatively, Oxa exerted an apoptotic effect on wild or mutant p53 colon cancer cells when combined with TPO-NANO, through a mechanism involving ROS-mediated mitochondrial apoptosis.
Institutional Quality and Economic Growth: Evidence from Nigeria
Creators: name: Abubakar, Sule
name: Abubakar, Sule
Publisher: name: Unknown
Year: 2020
Subjects: subject: Financial Economics
subject: Research Methods/ Statistical Methods
subject: Economic Growth
subject: Institutional Quality
subject: Domestic Investment
subject: Foreign Direct
subject: Investment
subject: Government Expenditure
subject: Contract Intensive Money

description: This study ascertained the directional effect of institutional quality through contract intensive money and effective governance index to economic growth in Nigeria using annual time series data covering the period 1979 to 2018. The study hinges on both the Solow-Swan neoclassical growth model and Washington Consensus to provide insight on the policy necessity for institutional quality. To achieve this, the study employs both the Johansen Cointegration and Ordinary Least Square (OLS) approach. The estimated cointegration test reveals joint relationship among the variables. OLS model shows that economic growth responds positively to institutional quality (contract intensive money) and is statistically significant while effective governance index exert positive and insignificant influence on the economy. The empirical results further reveal that economic growth respond positively and negative to the effect from the variables of domestic investment and foreign direct investment but significant. Furthermore, it takes 34% for the model to adjust to equilibrium in the long-term. The findings lend support to calls for quality institutions that can ensure that both private and public enterprise functions efficiently for sustainable growth and development in Nigeria.
title: ADCO, Sixième cartulaire de Saint-Étienne de Dijon (1662), Cart. 30 (G 133), 441 folios, f. 564
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 564, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 564, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
BPS Boojums in N=2 supersymmetric gauge theories II
Creators: name: Arai, Masato
name: Blaschke, Filip
name: Eto, Minoru
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We continue our study of 1/4 Bogomol'nyi-Prasad-Sommerfield (BPS) composite solitons of vortex strings, domain walls and boojums in N=2 supersymmetric Abelian gauge theories in four dimensions. In this work, we numerically confirm that a boojum appearing at an end point of a string on a thick domain wall behaves as a magnetic monopole with a fractional charge in three dimensions. We introduce a "magnetic" scalar potential whose gradient gives magnetic fields. Height of the magnetic potential has a geometrical meaning that is shape of the domain wall. We find a semi-local extension of boojum which has an additional size moduli at an end point of a semi-local string on the domain wall. Dyonic solutions are also studied and we numerically confirm that the dyonic domain wall becomes an electric capacitor storing opposite electric charges on its skins. At the same time, the boojum becomes fractional dyon whose charge density is proportional to ${\vec E} \cdot {\vec B}$. We also study dual configurations with an infinite number of boojums and anti-boojums on parallel lines and analyze the ability of domain walls to store magnetic charge as magnetic capacitors. In understanding these phenomena, the magnetic scalar potential plays an important role. We study the composite solitons from the viewpoints of the Nambu-Goto and Dirac-Born-Infeld actions, and find the semi-local BIon as the counterpart of the semi-local Boojum.
description: 75 pages, 29 figures. This paper is a division of arXiv:1603.00447
Additional file 5 of Application of objective structured clinical examination (OSCE) for the evaluation of Kampo medicine training
Creators: name: Amitani, Marie
name: Amitani, Haruka
name: Suzuki, Hajime
name: Kawazu, Suguru
name: Mizuma, Kimiko
name: Yamaguchi, Kojiro
name: Oki, Toshimichi
name: Nitta, Hideaki
name: Sonoda, Takuro
name: Kawano, Keiko
name: Tanaka, Yasuhiro
name: Uto, Nanami
name: Ibusuki, Rie
name: Arita, Ryutaro
name: Takayama, Shin
name: Mitsuma, Tadamichi
name: Takezaki, Toshiro
name: Asakawa, Akihiro
name: Owaki, Tetsuhiro
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Hematology

description: Additional file 5. Kampo-OSCE time schedule.
Additional file 3: Figure S2. of In-depth proteomic analysis of boar spermatozoa through shotgun and gel-based methods
Creators: name: Feugang, Jean
name: Shengfa Liao
name: Willard, Scott
name: Ryan, Peter
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: Representative two-dimensional gel electrophoresis of the boar sperm proteome. (PDF 84Â kb)
Chidamide stacked in magnetic polypyrrole nano-composites counter thermotolerance and metastasis for visualized cancer photothermal therapy
Creators: name: Wang, Sizhen
name: Ma, Zhiqiang
name: Shi, Zhang
name: Huang, Ying
name: Chen, Tianheng
name: Hou, Lei
name: Jiang, Tao
name: Yang, Feng
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Space Science
Medicine
Pharmacology
Biological Sciences not elsewhere classified
Cancer

description: Photothermal therapy (PTT) has become one of the most promising therapies in cancer treatment as its noninvasiveness, high selectivity, and favorable compliance in clinic. However, tumor thermotolerance and distal metastasis reduce its efficacy, becoming the bottleneck of applying PTT in clinic. In this study, a chidamide-loaded magnetic polypyrrole nanocomposite (CMPP) has been fabricated as a visualized cancer photothermal agent (PTA) to counter tumor thermotolerance and metastasis. The efficacy of CMPP was characterized by in vitro and in vivo assays. As a result, this kind of magnetic polypyrrole nanocomposites were black spherical nanoparticles, possessing a favorable photothermal effect and the suitable particle size of 176.97 ± 1.45 nm with a chidamide loading rate of 12.92 ± 0.45%. Besides, comparing with PTT, CMPP exhibited significantly higher cytotoxicity and cellular apoptosis rate in two tumor cell lines (B16-F10 and HepG2). In vivo study, the mice showed obvious near-infrared (NIR) and magnetic resonance imaging (MRI) dual-modal imaging at tumor sites and sentinel lymph nodes (SLNs); on the other hand, magnetic targeting guided CMPP achieved a cure level on melanoma-bearing mice through preventing metastasis and thermotolerance. Overall, with high loading efficiency of chidamide and strong magnetic targeting to tumor sites and SLNs, CMPP could significantly raise efficiency of PTT by targeting tumor thermotolerance and metastasis, and this strategy may be exploited therapeutically to upgrade PTT with MPP as one of appropriate carriers for histone deacetylase inhibitors (HDACis).
Musical intervals under 12-note equal temperament: a geometrical interpretation
Creators: name: Caimmi, R.
name: Franzon, A.
name: Tognon, S.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Combinatorics (math.CO)
subject: History and Overview (math.HO)
subject: FOS: Mathematics

description: Musical intervals in multiple of semitones under 12-note equal temperament, or more specifically pitch-class subsets of assigned cardinality ($n$-chords) are conceived as positive integer points within an Euclidean $n$-space. The number of distinct $n$-chords is inferred from combinatorics with the extension to $n=0$, involving an Euclidean 0-space. The number of repeating $n$-chords, or points which are turned into themselves during a circular permutation, $T_n$, of their coordinates, is inferred from algebraic considerations. Finally, the total number of $n$-chords and the number of $T_n$ set classes are determined. Palindrome and pseudo palindrome $n$-chords are defined and included among repeating $n$-chords, with regard to an equivalence relation, $T_n/T_nI$, where reflection is added to circular permutation. To this respect, the number of $T_n$ set classes is inferred concerning palindrome and pseudo palindrome $n$-chords and the remaining $n$-chords. The above results are reproduced within the framework of a geometrical interpretation, where positive integer points related to $n$-chords of cardinality, $n$, belong to a regular inclined $n$-hedron, $Ψ_{12}^n$, the vertexes lying on the coordinate axes of a Cartesian orthogonal reference frame at a distance, $x_i=12$, $1\le i\le n$, from the origin. Considering $Ψ_{12}^n$ as special cases of lattice polytopes, the number of related nonnegative integer points is also determined for completeness. A comparison is performed with the results inferred from group theory.
description: 56 pages, 7 tables, 3 figures
Additional file 1: Figure S1. of microRNAs associated with early neural crest development in Xenopus laevis
Creators: name: Ward, Nicole
name: Green, Darrell
name: Higgins, Janet
name: Dalmay, Tamas
name: MĂźnsterberg, Andrea
name: Moxon, Simon
name: Wheeler, Grant
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Validation of tissue induction (A) PCR on RNA extracted from stage 15 animal cap tissue induced to become either neural or NC showed that tissue was induced efficiently. The NC marker Snail2 was only expressed in the NC animal cap tissue whilst the neural marker Sox2 was enriched in the neural tissue and epidermal keratin was enriched in the ectoderm (Ecto) sample. Histone H4 was used as a positive control and Bracyury for a control of mesoderm contamination Whole embryos (WE) were used a positive controls for all genes. (B) WISH for the NC marker Sox10 on stage 15 induced animal caps. This is further confirmation of induction of NC tissue as expression is only evident in NC animal caps. (DOCX 7118Â kb)
A pH-responsive complex based on supramolecular organic framework for drug-resistant breast cancer therapy
Creators: name: Zhang, Yun-Chang
name: Zeng, Pei-Yu
name: Ma, Zhi-Qiang
name: Xu, Zi-Yue
name: Wang, Ze-Kun
name: Guo, Beibei
name: Yang, Feng
name: Li, Zhan-Ting
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Space Science
Medicine
Pharmacology
Biotechnology
Cancer
Hematology

description: Chemotherapy is one of the main ways to treat breast cancer clinically. However, the multidrug resistance to anti-tumor drugs limits their clinical use. To overcome these drawbacks, the development of drug delivery systems (DDSs) has attracted more and more attention in cancer therapy. At present, the preparation and purification process are complicated for many reported DDSs, while the clinic calls for new DDSs that are more convenient for preparation. Here a new pH-responsive supramolecular organic framework drug delivery complex loading doxorubicin (DOX) is fabricated. Anti-tumor activity of the system in vitro was investigated by cell cytotoxicity, uptake assay, and cell apoptosis analysis. The anti-tumor activity in vivo was investigated by inspecting nude mice body weight, tumor volume and weight, also a preliminary mechanism probe was conducted by HE and TUNEL staining. The DOX@SOF displayed high stability, good biocompatibility and pH-regulated drug release. At acid condition, the hydrazone bonds would be broken, which result in the dissociation of SOF, and then the drugs would be released from the system. Furthermore, DOX@SOF enhanced cellular internalization. Both in vitro and in vivo experiments reflected that DOX@SOF could enhance the anti-tumor activity of DOX. for the MCF-7/ADR tumor cells and tumors. This study provides a highly efficient strategy to prepare a stimulus-responsive supramolecular drug delivery complex for the treatment of drug-resistant cancer, the results presented inspiring scientific interests in exploring new drug delivery strategies and reversing multi-drug resistance for clinical chemotherapy.
Additional file 1 of Estimating errors in autocorrelation functions for reliable investigations of reflection profiles
Creators: name: Maeda, Yuta
name: Watanabe, Toshiki
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
Additional file 4: of Efficacy of pre-operative quadriceps strength training on knee-extensor strength before and shortly following total knee arthroplasty: protocol for a randomized, dose-response trial (The QUADX-1 trial)
Creators: name: Husted, Rasmus
name: Troelsen, Anders
name: Thorborg, Kristian
name: Rathleff, Michael
name: Husted, Henrik
name: Bandholm, Thomas
Publisher: name: figshare
Year: 2018
Subjects: Biophysics
Medicine
Molecular Biology
Pharmacology

description: Administrative information. (DOCX 38Â kb)
Policy brief: Academia-driven open innovation for the revival of small and medium cultural heritage organisations (CHOs)
Creators: name: Zourou, Katerina
name: Oikonomou, Stefania
Publisher: name: Zenodo
Year: 2024

description: This policy brief has been curated by the Erasmus+ project “Recovery of cultural heritage through highereducation-driven open innovation” (eCHOIng, https://www.ntnu.edu/echoing/). eCHOIng investigates the ways in which higher education institutions (HEIs) support cultural heritage revival after the COVID-19 pandemic. The reflections contained in this document were inspired by the synthesis of the publication “Practices in the revival of European cultural heritage organisations through university-driven open innovation”.
Nucleosynthesis in thermonuclear supernovae
Creators: name: Seitenzahl, Ivo R.
name: Townsley, Dean M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The explosion energy of thermonuclear (Type Ia) supernovae is derived from the difference in nuclear binding energy liberated in the explosive fusion of light 'fuel' nuclei, predominantly carbon and oxygen, into more tightly bound nuclear 'ash' dominated by iron and silicon group elements. The very same explosive thermonuclear fusion event is also one of the major processes contributing to the nucleosynthesis of the heavy elements, in particular the iron-group elements. For example, most of the iron and manganese in the sun and its planetary system were produced in thermonuclear supernovae. Here, we review the physics of explosive thermonuclear burning in carbon-oxygen white dwarf material and the methodologies utilized in calculating predicted nucleosynthesis from hydrodynamic explosion models. While the dominant explosion scenario remains unclear, many aspects of the nuclear combustion and nucleosynthesis are common to all models and must occur in some form in order to produce the observed yields. We summarize the predicted nucleosynthetic yields for existing explosion models, placing particular emphasis on characteristic differences in the nucleosynthetic signatures of the different suggested scenarios leading to Type Ia supernovae. Following this, we discuss how these signatures compare with observations of several individual supernovae, remnants, and the composition of material in our galaxy and galaxy clusters.
description: Author version of a chapter for the 'Handbook of Supernovae', edited by A. Alsabti and P. Murdin, Springer. 22 pages, 2 figures
Assessment of antifungal efficacy of itraconazole loaded aspasomal cream: comparative clinical study
Creators: name: Lamie, Caroline
name: Elmowafy, Enas
name: Ragaie, Maha H.
name: Attia, Dalia A.
name: Mortada, Nahed D.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Topical conveyance of antifungal agents like itraconazole ITZ has been giving good grounds for expecting felicitous antifungal medicines. The defiance of topical delivery of this poorly water soluble and high-molecular-weight drug, however, mightily entail an adequate vehiculation. ITZ aspasomes, newer antioxidant generation of liposomes, have been designed and enclosed in a cream to ameliorate skin deposition. The proposed creams containing non-formulated ITZ or encapsulated in aspasomes (0.1% or 0.5%) were topically applied in patients with diagnosed diaper dermatitis complicated by candidiasis, tinea corporis (TC), and tinea versicolor (TVC). Placebos (void aspasomal cream and cream base) were also utilized. The obtained results for diaper rash revealed that aspasomal cream (0.5% ITZ) was eminent with respect to complete cure and negative candida culture after 10-day therapy relative to counterparts containing 0.1% ITZ aspasomes or non-formulated ITZ (0.1% and 0.5%). For tinea, the same trend was manifested in terms of ‘cleared’ clinical response in 90% of patients and absence of fungal elements after 4-week treatment. Relative to non-formulated ITZ, ITZ aspasomal cream was endorsed to be auspicious especially when ITZ concentration was lowered to half commercially available cream concentration (1%), pushing further exploitation in other dermal fungal infections.
Additional file 3: of Efficacy of pre-operative quadriceps strength training on knee-extensor strength before and shortly following total knee arthroplasty: protocol for a randomized, dose-response trial (The QUADX-1 trial)
Creators: name: Husted, Rasmus
name: Troelsen, Anders
name: Thorborg, Kristian
name: Rathleff, Michael
name: Husted, Henrik
name: Bandholm, Thomas
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Pharmacology

description: Patient brochure (English). (PDF 825Â kb)
Testing the Quantity Theory of Money in Zimbabwe under the Multiple Currency Regime: An ARDL Bound Testing Approach
Creators: name: Regret, Sunge
name: Makamba, Biatrice Simbisai
name: Regret, Sunge
name: Makamba, Biatrice Simbisai
Publisher: name: Unknown
Year: 2020
Subjects: subject: Financial Economics
subject: Research Methods/ Statistical Methods
subject: Quantity Theory of Money
subject: Multiple Currency
subject: ARDL Bound Testing Cointegration

description: Validity of the Quantity Theory of Money (QTM) continues to be heavily contested. The current examination is born out of the realization that there is no evidence for an economy using multiple currencies and deprived of monetary policy sovereignty. Using the Auto-Regressive Distributed-Lag approach to long-run association and co-integration analysis, we document weak evidence for the QTM for the period 01/01/2009-31/03/2018. However post-introduction of bond coins and notes in December 2014, we find sufficient evidence for the QTM. After controlling for other determinants, budget deficit was found to be the major peddler of inflation. We deduce that the multiple currency diluted the central bank’s discretion over monetary policy. We welcome the scraping of the multiple currency system. Nevertheless, to safeguard the abuse of the restored monetary policy sovereignty, we recommend money supply targeting as the primary monetary policy target.
A Joint Analysis for Cosmology and Photometric Redshift Calculation Using Cross Correlations
Creators: name: McLeod, Michael
name: Balan, Sreekumar T.
name: Abdalla, Filipe B.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a method of calibrating the properties of photometric redshift bins as part of a larger Markov Chain Monte Carlo (MCMC) analysis for the inference of cosmological parameters. The redshift bins are characterised by their mean and variance, which are varied as free parameters and marginalised over when obtaining the cosmological parameters. We demonstrate that the likelihood function for cross-correlations in an angular power spectrum framework tightly constrains the properties of bins such that they may be well determined, reducing their influence on cosmological parameters and avoiding the bias from poorly estimated redshift distributions. We demonstrate that even with only three photometric and three spectroscopic bins, we can recover accurate estimates of the mean redshift of a bin to within $Δμ\approx 3-4 \times10^{-3}$ and the width of the bin to $Δσ\approx 1\times10^{-3}$ for galaxies near $z = 1$. This indicates that we may be able to bring down the photometric redshift errors to a level which is in line with the requirements for the next generation of cosmological experiments.
description: 12 Pages, 6 figures
QISHLOQLARDA MEHNATGA HAQ TOʻLASH VA PENSIYA TIZIMIDAGI OʻZGARISHLAR (1945-1965-YILLAR FARGʻONA VODIYSI VILOYATLARI MISOLIDA)
Creators: name: Sobirov, Jamshidbek
Publisher: name: Zenodo
Year: 2025

description: Mazkur maqolada 1945–1965-yillar davomida Fargʻona vodiysi viloyatlarida (Fargʻona, Andijon va Namangan) qishloq joylarda mehnatga haq toʻlash va pensiya ta’minoti tizimidagi oʻzgarishlar tarixiy asosda tahlil etiladi. Asosiy e’tibor urushdan keyingi davrda kolxoz va sovxozlarda ishlayotgan dehqonlar mehnatining iqtisodiy bahosi, davlat tomonidan belgilangan ish haqi stavkalari, shuningdek, kolxozchilarga nisbatan pensiya ta’minoti bilan bogʻliq yangilanishlarga qaratilgan. Maqola arxiv materiallari, davr matbuoti, statistik ma’lumotlar va ilmiy adabiyotlar asosida tayyorlangan boʻlib, sovet mehnat siyosatining hududiy va ijtimoiy tafovutlarini ochib beradi.
Quantum acoustics with superconducting qubits
Creators: name: Chu, Yiwen
name: Kharel, Prashanta
name: Renninger, William H.
name: Burkhart, Luke D.
name: Frunzio, Luigi
name: Rakich, Peter T.
name: Schoelkopf, Robert J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The ability to engineer and manipulate different types of quantum mechanical objects allows us to take advantage of their unique properties and create useful hybrid technologies. Thus far, complex quantum states and exquisite quantum control have been demonstrated in systems ranging from trapped ions to superconducting resonators. Recently, there have been many efforts to extend these demonstrations to the motion of complex, macroscopic objects. These mechanical objects have important applications as quantum memories or transducers for measuring and connecting different types of quantum systems. In particular, there have been a few experiments that couple motion to nonlinear quantum objects such as superconducting qubits. This opens up the possibility of creating, storing, and manipulating non-Gaussian quantum states in mechanical degrees of freedom. However, before sophisticated quantum control of mechanical motion can be achieved, we must realize systems with long coherence times while maintaining a sufficient interaction strength. These systems should be implemented in a simple and robust manner that allows for increasing complexity and scalability in the future. Here we experimentally demonstrate a high frequency bulk acoustic wave resonator that is strongly coupled to a superconducting qubit using piezoelectric transduction. In contrast to previous experiments with qubit-mechanical systems, our device requires only simple fabrication methods, extends coherence times to many microseconds, and provides controllable access to a multitude of phonon modes. We use this system to demonstrate basic quantum operations on the coupled qubit-phonon system. Straightforward improvements to the current device will allow for advanced protocols analogous to what has been shown in optical and microwave resonators, resulting in a novel resource for implementing hybrid quantum technologies.
description: 21 pages, 12 figures, including supplementary information
Additional file 1 of Physical separation of haplotypes in dikaryons allows benchmarking of phasing accuracy in Nanopore and HiFi assemblies with Hi-C data
Creators: name: Duan, Hongyu
name: Jones, Ashley W.
name: Hewitt, Tim
name: Mackenzie, Amy
name: Hu, Yiheng
name: Sharp, Anna
name: Lewis, David
name: Mago, Rohit
name: Upadhyaya, Narayana M.
name: Rathjen, John P.
name: Stone, Eric A.
name: Schwessinger, Benjamin
name: Figueroa, Melania
name: Dodds, Peter N.
name: Periyannan, Sambasivam
name: Sperschneider, Jana
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Figures S1-S3. Supplementary figures. Various supplementary figures.
Semiclassical cosmology with polymer matter
Creators: name: Hassan, Syed Moeez
name: Husain, Viqar
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In loop quantum cosmology, polymer quantization is applied to gravity and Schrodinger quantization to matter. This approach misses interesting cosmological dynamics coming from the polymer quantization of matter. We demonstrate this in semiclassical cosmology with a scalar field and pressureless dust: gravity is kept classical, dust is used to fix the time gauge, and polymer quantization effects are isolated in the scalar field. The resulting dynamics shows a period of inflation, both with and without a scalar potential, and the emergence of a classical universe at late times. Since gravity is not quantized, the cosmological singularity is not resolved, but our results suggest that polymer quantization of both gravity and matter are important for a complete picture.
description: 11 pages, 3 figures. (CQG Focus issue: Applications of loop quantum gravity to cosmology)
Additional file 1: of A qualitative study of tobacco interventions for LGBTQ+ youth and young adults: overarching themes and key learnings
Creators: name: N. Bruce Baskerville
name: Wong, Katy
name: Shuh, Alanna
name: Abramowicz, Aneta
name: Darly Dash
name: Aamer Esmail
name: Kennedy, Ryan
Publisher: name: figshare
Year: 2018
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: LGBTQ+ Project: Focus Group Script and Questions. (DOCX 29 kb)
On the solution of a pairing problem in the continuum
Creators: name: Mercenne, A.
name: Michel, N.
name: Dukelsky, J.
name: Płoszajczak, M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We present a generalized Richardson solution for fermions interacting with the pairing interaction in both discrete and continuum parts of the single particle (s.p.) spectrum. The pairing Hamiltonian is based on the rational Gaudin (RG) model which is formulated in the Berggren ensemble. We show that solutions of the generalized Richardson equations are exact in the two limiting situations: (i) in the pole approximation and (ii) in the s.p. continuum. If the s.p. spectrum contains both discrete and continuum parts, then the generalized Richardson equations provide accurate solutions for the Gamow Shell Model.
Iodinated cyanine dye-based nanosystem for synergistic phototherapy and hypoxia-activated bioreductive therapy
Creators: name: Dong, Yunxia
name: Zhou, Ling
name: Shen, Zijun
name: Ma, Qingming
name: Zhao, Yifan
name: Sun, Yong
name: Cao, Jie
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Photodynamic therapy (PDT) has been applied in cancer treatment by utilizing reactive oxygen species (ROS) to kill cancer cells. However, the effectiveness of PDT is greatly reduced due to local hypoxia. Hypoxic activated chemotherapy combined with PDT is expected to be a novel strategy to enhance anti-cancer therapy. Herein, a novel liposome (LCT) incorporated with photosensitizer (PS) and bioreductive prodrugs was developed for PDT-activated chemotherapy. In the design, CyI, an iodinated cyanine dye, which could simultaneously generate enhanced ROS and heat than other commonly used cyanine dyes, was loaded into the lipid bilayer; while tirapazamine (TPZ), a hypoxia-activated prodrug was encapsulated in the hydrophilic nucleus. Upon appropriate near-infrared (NIR) irradiation, CyI could simultaneously produce ROS and heat for synergistic PDT and photothermal therapy (PTT), as well as provide fluorescence signals for precise real-time imaging. Meanwhile, the continuous consumption of oxygen would result in a hypoxia microenvironment, further activating TPZ free radicals for chemotherapy, which could induce DNA double-strand breakage and chromosome aberration. Moreover, the prepared LCT could stimulate acute immune response through PDT activation, leading to synergistic PDT/PTT/chemo/immunotherapy to kill cancer cells and reduce tumor metastasis. Both in vitro and in vivo results demonstrated improved anticancer efficacy of LCT compared with traditional PDT or chemotherapy. It is expected that these iodinated cyanine dyes-based liposomes will provide a powerful and versatile theranostic strategy for tumor target phototherapy and PDT-induced chemotherapy.
Additional file 2 of Physical separation of haplotypes in dikaryons allows benchmarking of phasing accuracy in Nanopore and HiFi assemblies with Hi-C data
Creators: name: Duan, Hongyu
name: Jones, Ashley W.
name: Hewitt, Tim
name: Mackenzie, Amy
name: Hu, Yiheng
name: Sharp, Anna
name: Lewis, David
name: Mago, Rohit
name: Upadhyaya, Narayana M.
name: Rathjen, John P.
name: Stone, Eric A.
name: Schwessinger, Benjamin
name: Figueroa, Melania
name: Dodds, Peter N.
name: Periyannan, Sambasivam
name: Sperschneider, Jana
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2. Review history.
The HST Large Program on Omega Centauri. I. Multiple stellar populations at the bottom of the main sequence probed in NIR-Optical
Creators: name: Milone, A. P.
name: Marino, A. F.
name: Bedin, L. R.
name: Anderson, J.
name: Apai, D.
name: Bellini, A.
name: Bergeron, P.
name: Burgasser, A. J.
name: Dotter, A.
name: Rees, J. M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: As part of a large investigation with Hubble Space Telescope to study the faintest stars within the globular cluster Omega Centauri, in this work we present early results on the multiplicity of its main sequence (MS) stars, based on deep optical and near-infrared observations. By using appropriate color-magnitude diagrams we have identified, for the first time, the two main stellar populations I, and II along the entire MS, from the turn-off towards the hydrogen-burning limit. We have compared the observations with suitable synthetic spectra of MS stars and conclude that the two MSs are consistent with stellar populations with different metallicity, helium, and light-element abundance. Specifically, MS-I corresponds to a metal-poor stellar population ([Fe/H]~-1.7) with Y~ 0.25 and [O/Fe]~0.30. The MS-II hosts helium-rich (Y~0.37-0.40) stars with metallicity ranging from [Fe/H]~-1.7 to -1.4. Below the MS knee (mF160W~19.5, our photometry reveals that each of the two main MSs hosts stellar subpopulations with different oxygen abundances, with very O-poor stars ([O/Fe]~-0.5) populating the MS-II. Such a complexity has never been observed in previous studies of M-dwarfs in globular clusters. A few months before the lunch of the James Webb Space Telescope, these results demonstrate the power of optical and near-infrared photometry in the study of multiple stellar populations in globular clusters.
description: 13 pages, 9 figures, accepted for publication in MNRAS
title: Balsamaire (Inv. 2003.7.6941.4) – Oppidum de Bibracte
Creators: name: Bibracte
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: balsamaire

description: Forme  couleur et décor sont autant d’indices qui permettent à l’archéologue de préciser l’usage d’une poterie ou sa date de fabrication. Les jarres de grande taille servent au stockage. Les récipients plus petits  à la paroi épaisse et noircie  sont des pots à cuire. La vaisselle de table présente une plus grande diversité. Les pots à boisson aux formes élancées et aux surfaces sombres de style gaulois laissent progressivement la place à des cruches à pâte plus claire pourvues d’une ou deux anses. Les plats et assiettes dénotent très tôt l’influence romaine. L’évolution de leur forme suit de près celle de la céramique à vernis noir (“campanienne”) et à vernis rouge (“sigillée”) dont elle s’inspire.
Legumain/pH dual-responsive lytic peptide–paclitaxel conjugate for synergistic cancer therapy
Creators: name: Zheng, Shanshan
name: Cai, Yue
name: Hong, Yulu
name: Gong, Yubei
name: Gao, Licheng
name: Li, Qingyong
name: Li, Le
name: Sun, Xuanrong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: After molecule targeted drug, monoclonal antibody and antibody–drug conjugates (ADCs), peptide–drug conjugates (PDCs) have become the next generation targeted anti-tumor drugs due to its properties of low molecule weight, efficient cell penetration, low immunogenicity, good pharmacokinetic and large-scale synthesis by solid phase synthesis. Herein, we present a lytic peptide PTP7-drug paclitaxel conjugate assembling nanoparticles (named PPP) that can sequentially respond to dual stimuli in the tumor microenvironment, which was designed for passive tumor-targeted delivery and on-demand release of a tumor lytic peptide (PTP-7) as well as a chemotherapeutic agent of paclitaxel (PTX). To achieve this, tumor lytic peptide PTP-7 was connected with polyethylene glycol by a peptide substrate of legumain to serve as hydrophobic segments of nanoparticles to protect the peptide from enzymatic degradation. After that, PTX was connected to the amino group of the polypeptide side chain through an acid-responsive chemical bond (2-propionic-3-methylmaleic anhydride, CDM). Therefore, the nanoparticle (PPP) collapsed when it encountered the weakly acidic tumor microenvironment where PTX molecules fell off, and further triggered the cleavage of the peptide substrate by legumain that is highly expressed in tumor stroma and tumor cell surface. Moreover, PPP presents improved stability, improved drug solubility, prolonged blood circulation and significant inhibition ability on tumor growth, which gives a reasonable strategy to accurately deliver small molecule drugs and active peptides simultaneously to tumor sites.
Additional file 1 of Who is accessing community lateral flow device testing and why? Characteristics and motivations of individuals participating in COVID-19 community testing in two English local authority areas
Creators: name: Dalili, Michael N.
name: Long, Jo
name: Wadley, Emma
name: Sloan, Jack
name: Cross, Andrew
name: Thomas, Kyla H.
name: Morgan, Gemma
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1. Online survey questions sent to individuals who made a COVID-19 community LFD testing appointment at an LAA1 site.
Matrix completion with queries
Creators: name: Ruchansky, Natali
name: Crovella, Mark
name: Terzi, Evimaria
Publisher: name: arXiv
Year: 2017
Subjects: subject: Machine Learning (cs.LG)
subject: Social and Information Networks (cs.SI)
subject: FOS: Computer and information sciences

description: In many applications, e.g., recommender systems and traffic monitoring, the data comes in the form of a matrix that is only partially observed and low rank. A fundamental data-analysis task for these datasets is matrix completion, where the goal is to accurately infer the entries missing from the matrix. Even when the data satisfies the low-rank assumption, classical matrix-completion methods may output completions with significant error -- in that the reconstructed matrix differs significantly from the true underlying matrix. Often, this is due to the fact that the information contained in the observed entries is insufficient. In this work, we address this problem by proposing an active version of matrix completion, where queries can be made to the true underlying matrix. Subsequently, we design Order&Extend, which is the first algorithm to unify a matrix-completion approach and a querying strategy into a single algorithm. Order&Extend is able identify and alleviate insufficient information by judiciously querying a small number of additional entries. In an extensive experimental evaluation on real-world datasets, we demonstrate that our algorithm is efficient and is able to accurately reconstruct the true matrix while asking only a small number of queries.
description: Proceedings of the 21th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining
Additional file 1: Figure S1. of In-depth proteomic analysis of boar spermatozoa through shotgun and gel-based methods
Creators: name: Feugang, Jean
name: Shengfa Liao
name: Willard, Scott
name: Ryan, Peter
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: Sperm preparation and proteomics. (PDF 153Â kb)
Co-delivery of carbonic anhydrase IX inhibitor and doxorubicin as a promising approach to address hypoxia-induced chemoresistance
Creators: name: Amin, Muhammad Umair
name: Ali, Sajid
name: Ali, Muhammad Yasir
name: Fuhrmann, Dominik C.
name: Tariq, Imran
name: Seitz, Benjamin S.
name: Preis, Eduard
name: Brüßler, Jana
name: Brüne, Bernhard
name: Bakowsky, Udo
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Hypoxia, an oxygen-deprived condition of the tumor, is one of the major reasons for resistance to chemotherapy. Carbonic anhydrases are generally involved in pH homeostasis in normal conditions, but in solid tumors having a strong relation with hypoxia, the carbonic anhydrase IX (CA-IX) enzyme is overexpressed and results in an extracellular acidic environment. For most weakly basic anticancer drugs, including doxorubicin (Dox), the ionization in an acidic environment limits their cellular uptake, and consequently, the tumor exposure to the drug at sub-therapeutic concentration comes out as chemoresistance. Herein, a combined drug delivery system of liposomes and mesoporous silica nanoparticles (MSNPs) was developed for the co-delivery of the CA-IX enzyme inhibitor and Dox in hypoxic condition. The unique structure of MSNPs with higher surface area was utilized for higher drug loading and sustained release of Dox. Additionally, the biocompatible nature of liposomal coating as a second loading site for the CA-IX enzyme inhibitor has provided gatekeeping effects at pore opening to avoid premature drug release. Lipid coated MSNPs as a co-delivery system for Dox and the CA-IX inhibitor have synergistic cytotoxic effects against MDA-MB 231 breast cancer cells in hypoxic conditions. These findings assure the potential of this drug delivery system to overcome hypoxia-related chemoresistance.
title: ADCO, Grènetier de Cîteaux : comptes (1499-1503) (11 H 1173), f. 00760
Creators: name: de la Côte-d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Grènetier de Cîteaux : comptes (1499-1503), Archives départementales de la Côte-d'Or, (11 H 1173). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1499-1503), Archives départementales de la Côte-d'Or, (11 H 1173), f. 00760, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Gaussian intrinsic entanglement
Creators: name: Mišta, Ladislav
name: Tatham, Richard
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We introduce a cryptographically motivated quantifier of entanglement in bipartite Gaussian systems called Gaussian intrinsic entanglement (GIE). The GIE is defined as the optimized mutual information of a Gaussian distribution of outcomes of measurements on parts of a system, conditioned on the outcomes of a measurement on a purifying subsystem. We show that GIE vanishes only on separable states and exhibits monotonicity under Gaussian local trace-preserving operations and classical communication. In the two-mode case we compute GIE for all pure states as well as for several important classes of symmetric and asymmetric mixed states. Surprisingly, in all of these cases, GIE is equal to Gaussian Rényi-2 entanglement. As GIE is operationally associated to the secret-key agreement protocol and can be computed for several important classes of states it offers a compromise between computable and physically meaningful entanglement quantifiers.
description: 6+17 pages, 2 figures. Close to published version