cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: How Effective Is Algorithm-Guided Treatment for Depressed Inpatients?
title: Results from the Randomized Controlled Multicenter German Algorithm Project 3 Trial
titleType: Subtitle
Creators: name: Adli, Mazda
name: Wiethoff, Katja
name: Baghai, Thomas C.
name: Fisher, Robert
name: Seemüller, Florian
name: Laakmann, Gregor
name: Brieger, Peter
name: Cordes, Joachim
name: Malevani, Jaroslav
name: Laux, Gerd
name: Hauth, Iris
name: Möller, Hans-Jürgen
name: Kronmüller, Klaus-Thomas [U.A.]
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: treatment algorithms
subject: antidepressants
subject: treatment-resistant depression
subject: medical decision making
subject: German Algorithm Project
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Treatment algorithms are considered as key to improve outcomes by enhancing the quality of care. This is the first randomized controlled study to evaluate the clinical effect of algorithm-guided treatment in inpatients with major depressive disorder. Methods Inpatients, aged 18 to 70 years with major depressive disorder from 10 German psychiatric departments were randomized to 5 different treatment arms (from 2000 to 2005), 3 of which were standardized stepwise drug treatment algorithms (ALGO). The fourth arm proposed medications and provided less specific recommendations based on a computerized documentation and expert system (CDES), the fifth arm received treatment as usual (TAU). ALGO included 3 different second-step strategies: lithium augmentation (ALGO LA), antidepressant dose-escalation (ALGO DE), and switch to a different antidepressant (ALGO SW). Time to remission (21-item Hamilton Depression Rating Scale ≤9) was the primary outcome. Results Time to remission was significantly shorter for ALGO DE (n=91) compared with both TAU (n=84) (HR=1.67; P=.014) and CDES (n=79) (HR=1.59; P=.031) and ALGO SW (n=89) compared with both TAU (HR=1.64; P=.018) and CDES (HR=1.56; P=.038). For both ALGO LA (n=86) and ALGO DE, fewer antidepressant medications were needed to achieve remission than for CDES or TAU (P
Information und Kommunikation - steuernde Bausteine für die Leistungsfähigkeit von Handelsstrukturen für technische Gebrauchsgüter
Creators: name: Keller, Axel
Publisher: name: Piper
Year: 2010
Subjects: subject: 330 - Wirtschaft
subject: 659 - Werbung & Public Releations (PR)

description: Dieses Buch unternimmt einen Dreischritt aus Vergangenheit, Gegenwart und Zukunft. Vergangenheit: Vor 40 Jahren wurde die GfK Retail and Technology gegründet. Wie es dazu kam, wie in den Anfängen geforscht und wie die Entwicklung in Richtung Erfolg gesteuert wurde, ist der erste Schritt. Gegenwart: Wo steht der so erfolgreiche Businesssektor GfK Retail and Technology heute? Worauf kann man bauen, wie gelingt es, so viel Markt- und Methodenkompetenz zu erwerben, dass Retail and Technology relevante Erkenntnisse für Unternehmen anbieten kann? Sogar so weit, dass Problemstellungen identifiziert und analysiert werden, die die betroffenen Unternehmen selbst vielleicht noch gar nicht erkannt haben. Zukunft: Die digital-vernetzte Informations- und Wissensgesellschaft ist die Gesellschaft der Zukunft und die Welt, in der sich GfK Retail and Technology bewegen und weiter bewähren muss. Aus unterschiedlichen Blickwinkeln wird dies von hochkarätigen Experten beleuchtet.
Von der bloomschen Taxonomy zu aktuellen Bildungsstandards: Zur Entstehungs- und Rezeptionsgeschichte eines pädagogischen Bestsellers
Creators: name: Göldi, Susan
Publisher: name: hep
Year: 2011
Subjects: subject: 330 - Wirtschaft
subject: 659 - Werbung & Public Releations (PR)

description: Der bloomschen Taxonomy haftet etwas Faszinierendes an. Sie ist unglaublich bekannt, erscheint sehr vernünftig und doch weiss niemand so recht, wozu sie dient. Der vorliegende Band rekonstruiert, wie die Taxonomy als ein Produkt des amerikanischen Pragmatismus entstand. Er stellt Leben und Werk ihres Schöpfers, Benjamin Bloom, vor. Er zeigt, wie Motivationspsychologie, Humankapitaltheorie und Europäisierung sowie bedeutende Pädagogen wie Heinrich Roth, Wolfgang Klafki und Hans Aebli der Taxonomy und mit ihr der Zielorientierung in der Pädagogik den Weg bereiteten. Die Taxonomy erscheint als Teil einer kontinuierlichen Curriculumsentwicklung und damit als Instrument, um Unterricht zu evaluieren und weiterzuentwickeln. Weiter wohin? Die Zielorientierung mündet in die Diskussion von Möglichkeiten und Grenzen einer auf Effektivität, Effizienz und Leistungssteigerung programmierten Bildungspolitik.
Climate impact of aviation
Creators: name: Dahlmann, Katrin
name: Matthes, S.
name: Plohr, M.
Publisher: name: Umweltbundesamt
Year: 2023
Subjects: subject: Luftverkehr
subject: Strahlungsbilanz
subject: Brennstoff
subject: Petroleum
subject: air traffic
subject: Climate impact
subject: non-CO2 climate effects
subject: radiation budget
subject: fuel
subject: kerosene
subject: Climate | Energy
subject: Transport

description: Aviation affects the climate. Combustion of kerosene fuel results in carbon dioxide (CO2), but also other climate-impacting substances whose effects are referred to as "non-CO2 climate effects". What are these substances and how strong are their effects? How strong would the climate impact of air traffic be in the future if flying continues to grow as hitherto? How can the impact of air traffic on the climate be reduced through technical, organizational and regulatory measures? This brochure presents the current state of knowledge on the climate impact of air traffic in a generally understandable way. It shows possibilities at technical and legal level for reducing the impact on the climate, but also what passengers can do. The information brochure was produced by the German Aerospace Center on behalf of the German Federal Environment Agency. Quelle: www.umweltbundesamt.de
description: Aviation affects the climate. Combustion of kerosene fuel results in carbon dioxide (⁠CO2⁠), but also other climate-impacting substances whose effects are referred to as "non-CO2 climate effects". What are these substances and how strong are their effects? How strong would the climate impact of air traffic be in the future if flying continues to grow as hitherto? How can the impact of air traffic on the climate be reduced through technical, organizational and regulatory measures?This brochure presents the current state of knowledge on the climate impact of air traffic in a generally understandable way. It shows possibilities at technical and legal level for reducing the impact on the climate, but also what passengers can do.The information brochure was produced by the German Aerospace Center on behalf of the German Federal Environment Agency.
Metal nanoparticles: understanding the mechanisms behind antibacterial activity
Creators: name: Slavin, Yael N.
name: Asnis, Jason
name: Häfeli, Urs
name: Bach, Horacio
Publisher: name: BioMed Central
Year: 2017

description: As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action. The continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. Metal NPs are among the most promising of these because show strong antibacterial activity. This review summarizes and discusses proposed mechanisms of antibacterial action of different metal NPs. These mechanisms of bacterial killing include the production of reactive oxygen species, cation release, biomolecule damages, ATP depletion, and membrane interaction. Finally, a comprehensive analysis of the effects of NPs on the regulation of genes and proteins (transcriptomic and proteomic) profiles is discussed.
CD36/Sirtuin 1 Axis Impairment Contributes to Hepatic Steatosis in ACE2-Deficient Mice
Creators: name: Nunes-Souza, Valeria
name: Alenina, Natalia
name: Qadri, Fatimunnisa
name: Penninger, Josef M.
name: Santos, Robson Augusto S.
name: Bader, Michael
name: Rabelo, Luiza A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background and Aims. Angiotensin converting enzyme 2 (ACE2) is an important component of the renin-angiotensin system. Since angiotensin peptides have been shown to be involved in hepatic steatosis, we aimed to evaluate the hepatic lipid profile in ACE2-deficient (ACE2-/y) mice. Methods. Male C57BL/6 and ACE2-/y mice were analyzed at the age of 3 and 6 months for alterations in the lipid profiles of plasma, faeces, and liver and for hepatic steatosis. Results. ACE2-/y mice showed lower body weight and white adipose tissue at all ages investigated. Moreover, these mice had lower levels of cholesterol, triglycerides, and nonesterified fatty acids in plasma. Strikingly, ACE2-/y mice showed high deposition of lipids in the liver. Expression of CD36, a protein involved in the uptake of triglycerides in liver, was increased in ACE2-/y mice. Concurrently, these mice exhibited an increase in hepatic oxidative stress, evidenced by increased lipid peroxidation and expression of uncoupling protein 2, and downregulation of sirtuin 1. ACE2-/y mice also showed impairments in glucose metabolism and insulin signaling in the liver. Conclusions. Deletion of ACE2-/y causes CD36/sirtuin 1 axis impairment and thereby interferes with lipid homeostasis, leading to lipodystrophy and steatosis.
title:  Innovazioni e continuità nei percorsi di formazione dalla scuola all’università
Creators: name: Lopriore, Lucilla
Publisher: name: Roma Tre University
publisherIdentifier: https://ror.org/05vf0dg29
publisherIdentifierScheme: ROR
Year: 2025

description: Questo contributo si propone di offrire alcune riflessioni sui percorsi formativi e su recenti innovazioni didattiche presenti in Italia nella transizione tra scuola e università. Tali riflessioni nascono da esperienze di insegnamento e di formazione di docenti di lingua e di discipline non linguistiche, nonché da ricerche svolte sull’innovazione dell’insegnamento integrato di contenuti e lingua (CLIL) e sull’attuale condizione di ‘lingua franca’ che caratterizza la lingua inglese. La funzione e il ruolo della continuità nell’insegnamento, gli aspetti emergenti nella formazione dei docenti CLIL nonché la rilevanza degli aspetti interdisciplinari e del ruolo della lingua in contesti sempre più multilingui, sono presentati e discussi.

The aim of this contribution is to propose some reflections on teacher education programs and on recent teaching innovations introduced in Italy within the transition between school and university. These reflections arise from teaching and teacher education courses for language and content teachers, as well as from research studies on the innovation of content and language-integrated learning (CLIL) and on the current status of English as a ‘lingua franca’. The function and role of continuity in teaching, emerging aspects in CLIL teacher education as well as the relevance of interdisciplinary features and of the role of language in increasingly multilingual contexts are presented and discussed.
description: ἀγλαὰ δῶρα. Studi miscellanei in onore di Dora Faraci
The WiggleZ Dark Energy Survey: Direct constraints on blue galaxy intrinsic alignments at intermediate redshifts
Creators: name: Mandelbaum, Rachel
name: Blake, Chris
name: Bridle, Sarah
name: Abdalla, Filipe B.
name: Brough, Sarah
name: Colless, Matthew
name: Couch, Warrick
name: Croom, Scott
name: Davis, Tamara
name: Drinkwater, Michael J.
name: Forster, Karl
name: Glazebrook, Karl
name: Jelliffe, Ben
name: Jurek, Russell J.
name: Li, I-hui
name: Madore, Barry
name: Martin, Chris
name: Pimbblet, Kevin
name: Poole, Gregory B.
name: Pracy, Michael
name: Sharp, Rob
name: Wisnioski, Emily
name: Woods, David
name: Wyder, Ted
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: Correlations between the intrinsic shapes of galaxy pairs, and between the intrinsic shapes of galaxies and the large-scale density field, may be induced by tidal fields. These correlations, which have been detected at low redshifts (z<0.35) for bright red galaxies in the Sloan Digital Sky Survey (SDSS), and for which upper limits exist for blue galaxies at z~0.1, provide a window into galaxy formation and evolution, and are also an important contaminant for current and future weak lensing surveys. Measurements of these alignments at intermediate redshifts (z~0.6) that are more relevant for cosmic shear observations are very important for understanding the origin and redshift evolution of these alignments, and for minimising their impact on weak lensing measurements. We present the first such intermediate-redshift measurement for blue galaxies, using galaxy shape measurements from SDSS and spectroscopic redshifts from the WiggleZ Dark Energy Survey. Our null detection allows us to place upper limits on the contamination of weak lensing measurements by blue galaxy intrinsic alignments that, for the first time, do not require significant model-dependent extrapolation from the z~0.1 SDSS observations. Also, combining the SDSS and WiggleZ constraints gives us a long redshift baseline with which to constrain intrinsic alignment models and contamination of the cosmic shear power spectrum. Assuming that the alignments can be explained by linear alignment with the smoothed local density field, we find that a measurement of sigma_8 in a blue-galaxy dominated, CFHTLS-like survey would be contaminated by at most +/-0.02 (95% confidence level, SDSS and WiggleZ) or +/-0.03 (WiggleZ alone) due to intrinsic alignments. [Abridged]
Soluble Alpha-APP (sAPPalpha) Regulates CDK5 Expression and Activity in Neurons
Creators: name: Hartl, Daniela
name: Klatt, Stephan
name: Roch, Manfred
name: Konthur, Zoltan
name: Klose, Joachim
name: Willnow, Thomas E.
name: Rohe, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2013
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: A growing body of evidence suggests a role for soluble alpha-amyloid precursor protein (sAPPalpha) in pathomechanisms of Alzheimer disease (AD). This cleavage product of APP was identified to have neurotrophic properties. However, it remained enigmatic what proteins, targeted by sAPPalpha, might be involved in such neuroprotective actions. Here, we used high-resolution two- dimensional polyacrylamide gel electrophoresis to analyze proteome changes downstream of sAPPalpha in neurons. We present evidence that sAPPalpha regulates expression and activity of CDK5, a kinase that plays an important role in AD pathology. We also identified the cytoprotective chaperone ORP150 to be induced by sAPPalpha as part of this protective response. Finally, we present functional evidence that the sAPPalpha receptor SORLA is essential to mediate such molecular functions of sAPPalpha in neurons.
Übersicht zur ökologischen Situation ausgewählter Tagebauseen des Braunkohlebergbaus in Deutschland
Creators: name: Nixdorf, Brigitte
name: Ramm, Jessica
Publisher: name: My University
Year: 2016
Subjects: subject: Ökologische Bewertung
subject: Braunkohlerevier
subject: Braunkohlenbergbau
subject: Stehendes Gewässer
subject: Baggersee
subject: Bergbaufolgelandschaft
subject: Restloch
subject: Tagebaurestsee
subject: Oberflächengewässer
subject: Bundesrepublik Deutschland
subject: Tagebausee
subject: Gewässerqualität
subject: Wasserrahmenrichtlinie
subject: EU-Wasserrahmenrichtlinie
subject: Braunkohlebergbau
subject: Braunkohlebergbaufolgelandschaft
subject: Wasser

description: Durch die Flutung alter Braunkohle-Tagebaue entstehen in Deutschland etwa 500 neue, künstliche Seen. Etwa 100 von ihnen sind größer als 50 Hektar und fallen damit unter die Vorgaben der EU-⁠Wasserrahmenrichtlinie⁠. Sie mussten bzw. müssen bis zum Jahr 2015 bzw. 2027 ein gutes ökologisches Potenzial erreichen und Deutschland ist über ihre Entwicklung berichtspflichtig. In dieser Studie wurden deshalb Typisierungs- und Bewertungsverfahren für neutrale und saure Tagebauseen in Anlehnung an die Bewertung natürlicher Seen entwickelt und angewendet. Für alle in dieser Studie betrachteten Tagebauseen wurden Seesteckbriefe entwickelt. Über die Hälfte der bewerteten Seen erreicht das gute ökologische Potenzial, 47 % der bewerteten Seen verfehlen es.
What makes young adults vulnerable to public stranger violence? Examining the influence of psycho-educational interventions on perceived vulnerability, fear of crime, intentions and behaviour
Creators: name: Maxwell, Lucy
Publisher: name: Swinburne
Year: 2024

description: This thesis examined the influence of psycho-educational interventions on young adults perceived vulnerability, fear of crime, intentions and behaviour. Highlighted was the need for anti-violence programs to address the misinformation that young adults hold about public stranger violence, inadvertently increasing their vulnerability. There is support that psycho-educational interventions decrease individual fear of crime. Thus, evidence-based information can empower individuals to mitigate their risk in public, reducing fear and the threat of public stranger. Increasing engagement in public life and decreasing fear have positive implications for mental health and well-being for those experiencing anxiety about public stranger victimisation.
The robustness of validity and efficiency of the one-sample t test in the presence of normal contamination.
Creators: name: Jennings, Martha.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Education, Tests and Measurements.

description: The performance of parametric tests given data which are essentially normal but contain outliers is largely unknown. In this Monte Carlo study the robustness of validity and efficiency for the one-sample location problem are investigated. The Type I error rate and power of the one-sample t test given a normal underlying population are compared with the performance of this test given a systematic range of outlier contamination in the underlying population. Sample sizes of 8, 16, 32, 64, and 128 are included in the design. The robustness of validity results are explored using three sets of regression models. The first set of models is constructed using the parameters of the contamination model and is intended to inform the social science methodologist. The second set of models is constructed using skewness and kurtosis values. A third set of models is developed using an index of contamination proposed by Zumbo (1993). This set of models has practical relevance to the data analyst confronted with outlier contaminated data. Robustness of efficiency results are expressed using both power curves and a proposed fairly stringent criterion for power. In general, the results indicate that the one-sample t test demonstrates fairly stringent robustness of validity for all the symmetric contamination explored. When contamination is asymmetric the Type I error rate becomes inflated as the proportion of contamination increases. If robustness of validity is intact, power is not greatly affected when medium or large effect sizes are examined. This is not necessarily true for small effect sizes and the problems are further exacerbated when sample sizes are also small.
3314865.pdf
Creators: name: Hummon, Matthew
name: Kang, Songbai
name: Bopp, Douglas
name: Li, Qing
name: Westly, Daron
name: Kim, Sangsik
name: Fredrick, Connor
name: Diddams, Scott
name: Srinivasan, Kartik
name: Aksyuk, Vladimir
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: Supplemental Material 1
Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling
Creators: name: Puttur, Franz
name: Francozo, Marcela
name: Solmaz, Guelhas
name: Bueno, Carlos
name: Lindenberg, Marc
name: Gohmert, Melanie
name: Swallow, Maxine
name: Tufa, Dejene
name: Jacobs, Roland
name: Lienenklaus, Stefan
name: Kuehl, Anja A.
name: Borkner, Lisa
name: Cicin-Sain, Luka
name: Holzmann, Bernard
name: Wagner, Hermann
name: Berod, Luciana
name: Sparwasser, Tim
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: MCMV
subject: NK cells
subject: plasmacytoid DC
subject: conventional DC
subject: TLR9-MyD88 signaling
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Cytomegalovirus (CMV) is an opportunistic virus severely infecting immunocompromised individuals. In mice, endosomal Toll-like receptor 9 (TLR9) and downstream myeloid differentiation factor 88 (MyD88) are central to activating innate immune responses against mouse CMV (MCMV). In this respect, the cell-specific contribution of these pathways in initiating anti-MCMV immunity remains unclear. Using transgenic mice, we demonstrate that TLR9/MyD88 signaling selectively in CD11c+ dendritic cells (DCs) strongly enhances MCMV clearance by boosting natural killer (NK) cell CD69 expression and IFN-γ production. In addition, we show that in the absence of plasmacytoid DCs (pDCs), conventional DCs (cDCs) promote robust NK cell effector function and MCMV clearance in a TLR9/MyD88-dependent manner. Simultaneously, cDC- derived IL-15 regulates NK cell degranulation by TLR9/MyD88-independent mechanisms. Overall, we compartmentalize the cellular contribution of TLR9 and MyD88 signaling in individual DC subsets and evaluate the mechanism by which cDCs control MCMV immunity.
title: Environmental information for products and services
title: Environmental information for products and services
titleType: AlternativeTitle
Creators: name: (:Unkn) Unknown
Publisher: name: Umweltbundesamt
Year: 2019
Subjects: Umweltinformation
Umweltzeichen
Produktkennzeichnung
Produktbezogene Umweltdeklaration
Ökobilanz
Umweltmanagementnorm ISO 14001

description: Among the general public, there is a growing awareness of the environmental impacts of products and escalating demands on companies to take environmental action through their products. As a result, product-related environmental information is becoming ever more important. The aims of this brochure are to: - provide an objective overview of the opportunities and tools for product-related environmental information, with a particular focus on the voluntary approaches available to companies alongside the mandatory information required by law. - outline reporting tools available for collating environment-related data over a productâ€Ìs lifecycle. - define the fundamental requirements associated with standardisation and the statutory regulations on product-related environmental information. - help companies select a suitable tool for their particular application, and - guide consumers through the various different levels.
Superexchange coupling in fluorides and fluoro-complexes of elements in the first transition series.
Creators: name: Kaseno, S. S. I.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1961
Subjects: subject: Chemistry, Inorganic.

description: Theories of magnetism with special reference to the indirect exchange mechanism and ligand field theory are discussed. The magnetic susceptibilities of VF3, MnF3, NiF 2-MgF2, K2NiF4-K2 MgF4, and K3NiF6-K2.8AlF 5.8 were studied range of 90°K to 300°K. The effective magnetic moments of the paramagnetic ions increases as their concentration in the solid solutions decreases. This is explained as being due to the presence of indirect interactions between paramagnetic ions in the pure substance which are decreased by magnetic dilution. It was found that the moments are still dependent upon temperature even at infinite dilution. This behaviour is ascribed to the orbital contribution which is itself temperature dependent. Evidence is adduced for the presence of Ni (III) ion impurities in the NiF2-MgF2 system when it is contaminated with traces of oxide.
Feinstaub Forschungsprojekte von 2005 bis 2013
Creators: name: Galander, Franziska
name: Pipke, Larissa
Publisher: name: My University
Year: 2014
Subjects: subject: Bibliographie
subject: UFORDAT
subject: Feinstaub
subject: Service

description: Die Bibliographie dokumentiert Forschungsprojekte zu Feinstaub aus den Jahren 2005 bis 2013.  Die Datenbank dokumentiert sowohl öffentlich geförderte Forschungsprojekte (Bund, Länder, Kommunen und EU) als auch privat finanzierte Forschung von Firmen, Stiftungen, Vereinen,Verbänden usw. Es sind alle Umweltthemen in UFORDAT vertreten, von A wie Abfall bis Z wie Zugvogel. Die Projektbeschreibungen umfassen u. a. Projekttitel, Kurzbeschreibung, Laufzeit, Institutionen, Projektleiter, Literatur, Internetlinks.
Improving the stability of 11C–labeled L-methionine with ascorbate
Creators: name: Woods, Michael
name: Leung, Leo
name: Frantzen, Kari
name: Garrick, Jennifer G
name: Zhang, Zhengxing
name: Zhang, Chengcheng
name: English, Wade
name: Wilson, Don
name: Bénard, François
name: Lin, Kuo-Shyan
Publisher: name: Springer International Publishing
Year: 2018

description: Background: Carbon-11 labeled L-methionine (11C–MET) is a popular tracer used in the clinic for imaging brain tumors with positron emission tomography. However, the stability of 11C–MET in its final formulation is not well documented in literature. Recently, we observed fast degradation of HPLC-purified 11C–MET over time, and systematic investigation was conducted to identify the cause. Results: In this study, we verified the degraded product as 11C–labeled methionine sulfoxide (11C–METSO). To minimize oxidation, ascorbate (100 ppm) was added to the HPLC eluant, and the resulting HPLC-purified 11C–MET was stable in the final formulation solution without noticeable degradation for up to 1 h after the end of synthesis. Conclusions: Our data suggest that to minimize degradation, ascorbate can be added to the 11C–MET formulation solution especially if it is not administered into patients soon after the end of synthesis.
Modelling a fun, inclusive and tolerant dance and movement based behavioural intervention programme for children with autism spectrum disorders in Sarawak
Creators: name: Teo, Jing Xin
Publisher: name: Swinburne
Year: 2024

description: This is a two-part research. First, a study of the needs of parents of children with autism through interviews with parents and relevant educators. Second, the conception, design, and modelling of a behavioural intervention programme. Intervention was delivered to 12 children through six months of dance classes. Findings showed that when children attended more classes, they exhibited fewer challenging behaviours. Interviews with parents at the end of the programme showed that all parents found it beneficial and a novel method of delivering intervention in Sarawak. This suggests there is a place for enjoyable alternative behavioural interventions for autism in Sarawak.
Collision-induced emission spectroscopy of small polyatomic molecules and tandem mass spectrometry of perfluorinated organics.
Creators: name: Dawson, Donald Frederick.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Chemistry, Physical.

description: The CIE studies presented in Chapter 2 consisted of a source generated fast moving 8 keV projectile-ion, M1+•, undergoing a collision encounter with a stationary target gas, G1, under single collision conditions (i.e., ≈90%T). During the collision event, a non-momentum transfer occurs, that deposits an amount of internal excitation energy, Delta(DeltaE int), into the projectile-ion, producing an excited electronic state (M1+•)* species. Thus the (M1 +•)* species may now exhibit optical emission and/or fragment into ground, M2+ + M3•, or excited, (M2)* + M3• M2+ + (M3•) *; (M2+)* + (M3•) *, electronic state dissociation products. Additionally, if the charge exchange process between M1+• and G1 is present, a ground M1, or excited (M1)* electronic state parent neutral may be produced. Thus, again the (M1)* species may now exhibit optical emissions and/or fragment into ground or excited electronic state dissociation products. As well, with respect to the stationary target gas the (G1)* and (G1+•)* species and/or their fragments may be produced. For the small polyatomic projectile-ions studied here of the N≡N+•, C≡O+•, O=C=O +•, O=C=C=O+• systems, intact parent-ion emissions were observed for all of them, except for the latter species. As well, intact parent neutral emissions were only observed for N≡N, C≡O. For the larger polyatomic projectile-ions studied here of the C6H6+•, C6F 6+•, and C4H4O+• systems, no intact-parent emissions were observed, only those of weak atomic and diatomic fragment emissions. The tandem mass spectrometry studies of perfluorinated organics, presented in Chapters 3 and 4, were conducted on a series of iodo, oxo and unsaturated compounds. In particular, the perfluoro iodo compounds were hoped (with iodine being such a good leaving group) to be possible ideal sources of unrearranged fragment perfluorocarbocations, CnF m+. However, unfortunately this did not always prove to be the case.(e.g., the primary metastable loss from (CF3) 3CI+• was unexpectedly FI and not I• ). For the perfluoro iodo compounds, the isomers of perfluorobutyl, C4F9I, and perfluoropropyl, C3F7I, iodides were utilized as precursors. (As well, (CF3)3C--C(CF 3)3 was utilized as a precursor for (CF3) 3C+). Specifically, it was proposed here that the (fragment) perfluorocarbocations, CnFm+ possessed a reserved cation stability order (i.e., primary > secondary > tertiary); CF 3CF2CF2CF2+ > (CF 3)3CFCF2+ > (CF3) 3C+; that is not seen in their respective hydrocarbon counterparts. (Abstract shortened by UMI.)
Unterbringung von Flüchtlingen in Deutschland
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: subject: KNBau
subject: Kommission Nachhaltiges Bauen
subject: Flüchtling
subject: Flüchtlingsunterkünfte
subject: Nachhaltiges Bauen
subject: Modularbauweise
subject: Wirtschaft | Konsum
subject: Nachhaltigkeit | Strategien | Internationales

description: In Deutschland ankommende Flüchtlinge müssen in der derzeitigen Lage schnell und kostengünstig untergebracht werden. Deshalb Qualitätsmerkmale und Anforderungsniveaus der Standort- und Gebäudequalität pauschal abzusenken, produziert jedoch Probleme in der Zukunft und führt zu keinen befriedigenden Lösungen. In diesem Positionspapier unterbreitet die Kommission Nachhaltiges Bauen am Umweltbundesamt (KNBau) erste Vorschläge für sinnvolle Lösungsansätze. Eine gute Lösung sind etwa Gebäudekonzepte, die hinsichtlich der Standards modular nachrüstbar und baukonstruktiv für verschiedene Nach- und Umnutzungen ausgelegt sind.
Quelle: Verlagsinformation
description: In Deutschland ankommende Flüchtlinge müssen in der derzeitigen Lage schnell und kostengünstig untergebracht werden. Deshalb Qualitätsmerkmale und Anforderungsniveaus der Standort- und Gebäudequalität pauschal abzusenken, produziert jedoch Probleme in der Zukunft und führt zu keinen befriedigenden Lösungen. In diesem Positionspapier unterbreitet die Kommission Nachhaltiges Bauen am Umweltbundesamt (KNBau) erste Vorschläge für sinnvolle Lösungsansätze. Eine gute Lösung sind etwa Gebäudekonzepte, die hinsichtlich der Standards modular nachrüstbar und baukonstruktiv für verschiedene Nach- und Umnutzungen ausgelegt sind.
Spectroscopic Studies of Bulk and Surface Interactions in the Condensed Phase
Creators: name: Chase, Zizwe Atiba
Publisher: name: Washington State University
Year: 2018
Subjects: Biomass energy -- Synthesis

description: The conversion of biomass into energy carriers in the condensed phase involves reactions in the presence of water mainly as a solvent. These chemical transformation of lignin-derived compounds to hydrocarbon fuels are performed at elevated temperature (473 K) and pressure (up to 50 bar H2) and therefore the state and stability of supported metal catalysts during reaction in the presence of water is not clear. Using in situ extended X-ray absorption fine structure spectroscopy, to better define the chemical state under dynamic variations of the environment, the noble metal Pd, the base metal Ni, and a bimetallic mixture of Ni and Fe were investigated under hydrothermal conditions. For Pd on various supports (C, Al2O 3, SiO2) water had no effect allowing its active phase (PdH x) to perform phenol hydrogenation. In the presence of water, Ni was found to be stable supported on HZSM-5 and sulfonated carbon while it transformed to Ni(II) phyllosilicate when supported on SiO2. This chemical state change lowers the hydrogenation activity of Ni on this support. Lastly, alloying Ni with Fe inhibits this undesired chemical state change for Ni(0) supported on SiO2 yet it also leads to a lowering of the hydrogenation activity that is speculated to be the result of a decreased amount of surface Ni available for reaction. Sum Frequency Generation was also used in a fundamental study to investigate diverse conformation of different interfaces to give a general understanding of surface interactions.
Bending Reality The Science and Applications of Temporal–Space Distortion
Creators: name: Jafari, Alan
Publisher: name: AlanJafari
Year: 2025
Subjects: spacetime curvature
warp metrics
temporal–space distortion
metamaterials
quantum field simulations
superluminal communication

description: This article presents a concise yet comprehensive overview of temporal–space distortion, detailing how Einstein’s general relativity can be harnessed to engineer spacetime through warp metrics and exotic matter distributions, and how contemporary advances in numerical relativity, metamaterial analogs, and quantum field simulations are bringing these concepts closer to experimental reality. It surveys foundational theory, including Alcubierre and Natário warp solutions, explores state‑of‑the‑art computational techniques and analog platforms—such as metamaterial waveguides and Bose–Einstein condensate models—and evaluates transformative applications in superluminal communication, advanced space navigation, and defense. The paper also critically addresses the formidable energy, stability, and ethical challenges of creating and controlling warp bubbles, and outlines a future research roadmap that leverages AI optimization, novel materials, and international governance frameworks to responsibly advance spacetime engineering .
Prophylactic pharmacotherapy for cholesterol reduction in the Canadian military: Potential for improved health and cost-effective health care.
Creators: name: Spaans, Johanna.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Health Sciences, Public Health.

description: Introduction. Statins may be under-prescribed in clinical settings. This study was undertaken to determine if the same is true in the military. The cost-effectiveness of statin therapy in patients identified by current Canadian cholesterol guidelines was also explored. Methods. Charts of 1424 Canadian military personnel (age ≥ 45) were reviewed at eleven Canadian bases. Risk factors and cholesterol values were used to identify drug therapy candidates and patients not being treated to target values. Cost-effectiveness ratios were estimated based on a systematic review of the literature. Results. 53/111 patients on therapy were not being treated to target cholesterol levels, while 172/1313 not on therapy were drug therapy candidates. An average of 2.89 years of life saved (YOLS) in drug therapy candidates was forecasted, costing less than $10,000/YOLS. Conclusion. The health benefits of statin therapy in this population are substantial and the cost-effectiveness is acceptable. Statin therapy warrants greater attention as a preventive strategy.
Localization of beta and high-frequency oscillations within the subthalamic nucleus region
Creators: name: Van Wijk, B. C. M.
name: Pogosyan, A.
name: Hariz, M. I.
name: Akram, H.
name: Foltynie, T.
name: Limousin, P.
name: Horn, A.
name: Ewert, S.
name: Brown, P.
name: Litvak, V.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Electrophysiology
subject: Oscillations
subject: Basal ganglia
subject: Cross-frequency coupling
subject: Parkinson's disease
subject: Motor system
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Parkinsonian bradykinesia and rigidity are typically associated with excessive beta band oscillations in the subthalamic nucleus. Recently another spectral peak has been identified that might be implicated in the pathophysiology of the disease: high-frequency oscillations (HFO) within the 150–400 Hz range. Beta-HFO phase-amplitude coupling (PAC) has been found to correlate with severity of motor impairment. However, the neuronal origin of HFO and its usefulness as a potential target for deep brain stimulation remain to be established. For example, it is unclear whether HFO arise from the same neural populations as beta oscillations. We intraoperatively recorded local field potentials from the subthalamic nucleus while advancing DBS electrodes in 2 mm steps from 4 mm above the surgical target point until 2 mm below, resulting in 4 recording sites. Data from 26 nuclei from 14 patients were analysed. For each trajectory, we identified the recording site with the largest spectral peak in the beta range (13–30 Hz), and the largest peak in the HFO range separately. In addition, we identified the recording site with the largest beta-HFO PAC. Recording sites with largest beta power and largest HFO power coincided in 50% of cases. In the other 50%, HFO was more likely to be detected at a more superior recording site in the target area. PAC followed more closely the site with largest HFO (45%) than beta power (27%). HFO are likely to arise from spatially close, but slightly more superior neural populations than beta oscillations. Further work is necessary to determine whether the different activities can help fine-tune deep brain stimulation targeting.
Factors Influencing Levels of CSR Disclosure by Forestry Companies in China
Creators: name: Lu, Feifei
name: Kozak, Robert A.
name: Toppinen, Anne
name: D’Amato, Dalia
name: Wen, Zuomin
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Abstract: With the international community’s increasing concern for social and environmental problems, the fulfilment and disclosure of corporate social responsibility (CSR) has been advocated and promoted across the world. Forestry companies, which are particularly sensitive to environmental and social issues, are increasingly developing and improving their levels of CSR disclosure. However, information on emerging country contexts is still lacking. To fill this gap, this study focuses on Chinese forestry companies’ CSR disclosure and introduces new disclosure indices through content analysis of annual reports by listed companies between 2011–2015. It then builds a correlation analysis of the factors influencing these companies’ disclosure indices in order to gain a better understanding of the current situation for CSR implementation by forestry companies in emerging economies like China. Although context-specific, our findings can provide a reference for researchers and policy makers, and promote sustainable development via improved CSR disclosure by forestry companies, especially in developing regions.
title: Lesotho: Basic and Nonformal Education Sytems (BANFES) Project Final Report
Creators: name: Pursley, Linda A.
Publisher: name: University of Massachusetts Amherst
Year: 1991
Subjects: subject: BANFES
subject: Lesotho
subject: teacher training
subject: home economics
subject: Curriculum and Instruction
subject: Education
subject: Elementary Education and Teaching
subject: Family and Consumer Sciences
subject: Teacher Education and Professional Development

description: BANFES was a USAID-funded project in Lesotho. The project focused on four parts of the Ministry of Education: the headquarters of the Ministry; the National Teacher Training College; the National curriculum Development Center; and, the Rural Skills Training Center. CIE worked with each of these four institutions to upgrade teacher training and provide integrated training packages appropriate to personnel needs across all project sectors. The CIE contract was for $4.5 million. I have chosen to report my work by logframe outputs, using the question and answer format developed by the Project Evaluation Office for conducting interviews and collecting data on initiatives which were not otherwise evaluated. The second section relates my work to the relevant contractual obligations. Finally, I attempt to summarize what has been accomplished, and to reflect on the current situation and possible directions for the future. My work with BANFES in Lesotho covers the period beginning in September 1985 and concluding in February 1991. Throughout this period, I have been assigned to work as "Practical Skills Education Specialist" at the National Teacher Training College (NTTC). In late 1988, I was asked to work cross-component with the Horne Economics and Health and Physical Education Divisions at the National Curriculum Development Centre (NCDC). Following the departure of the previous component coordinators in January 1990, I also assumed responsbility for coordination of Component II.
"Le Roland Furieux, Tragicomedie" / Jean de Mairet: Edition TEI basée sur l'edition critique de Joseph Harris
Creators: name: Tronch Pérez, Jesús
Publisher: name: Zenodo
Year: 2019
Subjects: TEI edition
early modern European theatre
French theatre 1500-1700
Jean Mairet

description: An electronic edition, encoded by Jesús Tronch in XML language following the Guidelines of the Text Encoding Initiative, of Joseph Harris's critical edition of Jean Mairet's tragicomedy Le Roland furieux for the EMOTHE Digital Library . This TEI edition is the basis of the HTML-PHP text published in this digital library.
description: Funded by Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigación (Spain) and FEDER/ERDF through project FFI2016-80314-P.
The sea within: embodied sensemaking among seafaring leaders
Creators: name: Roberts, Bradley Edward
Publisher: name: Swinburne
Year: 2024

description: This thesis explores the way that seafaring leaders (masters and chief engineers) make sense of critical events at sea. It examines the way in which their sensemaking is an embodied process (where mind/body and environment are highly enmeshed) rather than a purely rational, conscious thought process. The research employs narrative interpretation; concluding that there are bottom-up, neurobiological and sociological dynamics that sit outside conscious awareness yet shape the way seafaring leaders make sense of critical events and their roles. The thesis provides practical recommendations to improve safety at sea, and professional practice development among seafarers.
Acquired Alterations of Hypothalamic Gene Expression of Insulin and Leptin Receptors and Glucose Transporters in Prenatally High-Glucose Exposed Three- Week Old Chickens Do Not Coincide with Aberrant Promoter DNA Methylation
Creators: name: Rancourt, Rebecca C.
name: Schellong, Karen
name: Ott, Raffael
name: Bogatyrev, Semen
name: Tzschentke, Barbara
name: Plagemann, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Prenatal exposures may have a distinct impact for long-term health, one example being exposure to maternal ‘diabesity’ during pregnancy increasing offspring ‘diabesity’ risk. Malprogramming of the central nervous regulation of body weight, food intake and metabolism has been identified as a critical mechanism. While concrete disrupting factors still remain unclear, growing focus on acquired epigenomic alterations have been proposed. Due to the independent development from the mother, the chicken embryo provides a valuable model to distinctively establish causal factors and mechanisms. Aim The aim of this study was to determine the effects of prenatal hyperglycemia on postnatal hypothalamic gene expression and promoter DNA methylation in the chicken. Methods and Findings To temporarily induce high-glucose exposure in chicken embryos, 0.5 ml glucose solution (30 mmol/l) were administered daily via catheter into a vessel of the chorioallantoic egg membrane from days 14 to 17 of incubation. At three weeks of postnatal age, body weight, total body fat, blood glucose, mRNA expression (INSR, LEPR, GLUT1, GLUT3) as well as corresponding promoter DNA methylation were determined in mediobasal hypothalamic brain slices (Nucleus infundibuli hypothalami). Although no significant changes in morphometric and metabolic parameters were detected, strongly decreased mRNA expression occurred in all candidate genes. Surprisingly, however, no relevant alterations were observed in respective promoter methylation. Conclusion Prenatal hyperglycemia induces strong changes in later hypothalamic expression of INSR, LEPR, GLUT1, and GLUT3 mRNA. While the chicken provides an interesting approach for developmental malprogramming, the classical expression regulation via promoter methylation was not observed here. This may be due to alternative/interacting brain mechanisms or the thus far under-explored bird epigenome.
DYNAMO - II. Coupled stellar and ionized-gas kinematics in two low-redshift clumpy discs
Creators: name: Bassett, Robert
name: Glazebrook, Karl
name: Fisher, Deanne
name: Green, A. W.
name: Wisnioski, E.
name: Obreschkow, D.
name: Cooper, E. M.
name: Abraham, R. G.
name: Damjanov, I.
name: McGregor, P. J.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: We study the spatially resolved stellar kinematics of two star-forming galaxies at z ∼ 0.1 from the larger DYnamics of Newly Assembled Massive Objects (DYNAMO) sample. These galaxies, which have been characterized by high levels of star formation and large ionized-gas velocity dispersions, are considered possible analogues to high-redshift clumpy discs. They were observed using the Gemini Multi-Object Spectrograph instrument in integral field spectroscopy (IFS) mode at the Gemini Observatory with high spectral resolution (R ≃ 5400, equivalent to σ ≃ 24 km s−1 at the observed wavelengths) and ∼6 h exposure times in order to measure the resolved stellar kinematics via absorption lines. We also obtain higher quality emission-line kinematics than previous observations. The spatial resolution (1.2 kpc) is sufficient to show that the ionized gas in these galaxies (as traced by Hβ emission) is morphologically irregular, forming multiple giant clumps while stellar continuum light is smooth and well described by an exponential profile. Clumpy gas morphologies observed in IFS data are confirmed by complementary narrow-band Hα imaging from the Hubble Space Telescope. Morphological differences between the stars and ionized gas are not reflected dynamically as stellar kinematics are found to be closely coupled to the kinematics of the ionized gas: both components are smoothly rotating with large velocity dispersions (∼40 km s−1) suggesting that the high gas dispersions are not primarily driven by star formation feedback. In addition, the stellar population ages of these galaxies are estimated to be quite young (60-500 Myr). The large velocity dispersions measured for these young stars suggest that we are seeing the formation of thick discs and/or stellar bulges in support of recent models which produce these from clumpy galaxies at high redshift.