cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Identification of molecular changes and virulence determinants in a mouse adapted influenza virus A/FM/1/47.
Creators: name: Smeenk, Cecilia
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Biology, Molecular.

description: The human influenza virus A/FM/1/47 (FM) was mouse-adapted by serial lung passage to produce the more virulent variant A/FM/1/47-MA (FM-MA). Previous genetic analysis identified four genome segments, 4, 5, 7 and 8 that are statistically associated with virulence. The aim of this investigation was first, to find the mutations on these four genome segments and then to determine a role for these changes in disease production. Upon sequencing segments 4 and 7, single amino acid replacements were found at amino acid 47 of the HA2 subunit of the hemagglutinin (HA) and at amino acid 139 of the matrix protein (M1). Segments 5 and 8 had not mutated on mouse-adaption. Viral growth kinetics were studied both in the mouse lung and in cell culture with MDCK cells. For viral pathology, standard hematoxylin, phloxine, saffron staining of formalin fixed sections, fluorescent antibody labelling of frozen sections and flow cytometric analysis for infected cells and immune cell recruitment was used to detect differences between the viruses. The matrix protein has a role in both replication and pathology and its coding change can be observed as a shift on SDS-PAGE. It was shown that viruses containing the matrix protein of FM-MA could replicate as quickly and to as high a titer as FM-MA itself. In pathology, it was apparent that segment 7 contributes to the early onset of interstitial pneumonia and that these reassortants can infect a greater number of cells than FM or the segment 4 reassortants. The parental FM-MA strain infects more cells in the lung and is more virulent than FM X FM-MA reassortants containing segments 4 and 7. (Abstract shortened by UMI.)
King’s Men and Continentals: War and Slavery in Eighteenth-Century Massachusetts
Creators: name: Hannigan, John
Publisher: name: Brandeis University
Year: 2023
Subjects: Massachusetts
Military History

description: “King’s Men and Continentals: War & Slavery in Eighteenth-Century Massachusetts” argues that freedom’s course in Massachusetts was intimately linked to two elements of the eighteenth-century world: the creation of a distinctive slave system that historians have traditionally called “family slavery” and the province’s experiences during the great wars for empire that convulsed the British Atlantic world between 1713 and 1775. Although Massachusetts merchants began importing enslaved Africans into the province in the 1630s, they never trafficked in the same quantities as their colonial counterparts in the Chesapeake or the Caribbean. Because Massachusetts never became a slave society in Ira Berlin’s classic definition of the term, the system of slavery that developed in Massachusetts was different from that of the other British slave owning colonies. The provincial legislature never enacted a comprehensive slave code like those adopted in South Carolina or Barbados, for example, and the end result was an ambiguous set of laws and customs governing the enslaved which, among other things, allowed Black men to serve in provincial military forces to an extent that was virtually unique among other British colonies. As they served in provincial armies sent to conquer in the name of empire, enslaved blacks in Massachusetts were absorbed into the imperial culture of their white masters in a way that has never been fully realized. In the years leading to the Revolution, this meant that enslaved and free Blacks in Massachusetts were unique among their enslaved counterparts in the British Empire, fighting in the empire’s wars and participating in provincial politics in way that – although limited - was unheard of elsewhere in the English-speaking Atlantic World. That they could do so was due to the relationship between war and slavery in eighteenth-century Massachusetts.
Pastoral options for minority communities applied to the Archdiocese of Wellington.
Creators: name: O'Sullivan, Anthony Bernard.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Religion, General.

description: This canonical study explores the options open to a diocesan bishop for the provision of pastoral cue to people who do not readily find a place in the local parish. Particularly since the migrations from Europe to North America towards the end of the nineteenth century, the Roman Catholic Church bad established parishes for the various language groups as alternatives to the territorial parishes which were largely English-speaking. In 1952 Pope Pius XII's Exsul familia offered a further option called the "mission with care of souls" which allowed for greater flexibility. Since the Second Vatican Council, what was initially developed as migrant legislation now finds a broader application for any group which finds itself unable to benefit from the ordinary pastoral care offered by the territorial or local parish. In 1965 the Decree on the Pastoral Office of Bishops offered the following for Pastoral care, which it particularly applied to people on the move: "Special concern should be shown for those among the faithful who, on account of their way or condition of life, cannot sufficiently make use of the common and ordinary pastoral services of parish priests or are quite cut off from them. Among this group are very many migrants, exiles and refugees, seamen, airplane personnel, gypsies, and others of this kind." This solicitude now finds expression in c. 383 of the 1983 Code of Canon Law, where it no longer applies exclusively to migrant groups: "In exercising his pastoral office, the diocesan Bishop is to be solicitous for all Christ's faithful entrusted to his care, whatever their age, condition or nationality, whether they live in the territory or are visiting there. He is to show an apostolic spirit also to those who, because of their condition of life, are not sufficiently able to benefit from ordinary pastoral care, and to those who have lapsed from religious practice." Chapter One presents the European and North American context from which the law on parishes and the pastoral care of migrants has come. Chapter Two explores various papal, curial and Vatican Council documents from this century in which the law has been presented and applied. Documents since the Council, including the 1983 Code, have applied and fleshed out the cultural insights of the council. Chapter Three details the New Zealand context in which the law and people from Europe meet the people from the Pacific. Chapter Four applies the law to the New Zealand situation. It weighs the options of personal parish, quasi-parish, and chaplaincy within the territorial parishes for meeting the pastoral needs of the two sample groups of the indigenous Maori, and Samoan migrants and their descendants. The author concludes that the personal parish respects the freedom and rights of minority groups, and allows for integration from a position of strength.
Το θέατρο στη Θεσσαλονίκη τα χρόνια της επταετούς δικτατορίας, Διδ. διατριβή, Τμήμα Θεάτρου ΑΠΘ (Σεπτέμβριος 2009), 363 σ.
Creators: name: Καράογλου, Αντωνία
Publisher: name: Σκηνή
Year: 2010

description: Υπό διαμόρφωση.
description: Σκηνή, No 1 (2010)
Structural and Functional studies of the Hsp90 molecular chaperone
Creators: name: Jin, Yi
Publisher: name: Brandeis University
Year: 2021
Subjects: Hsp90
Molecular Biochemistry

description: ABSTRACT
description: Structural and Functional studies of the Hsp90 molecular chaperone
description: A dissertation presented to the Faculty of the
description: Graduate School of Arts and Sciences of Brandeis University
description: Waltham, Massachusetts
description: By Yi Jin
description: Hsp90 and Hsp70 are ATP-dependent molecular chaperones that are responsible for efficient protein (“client”) folding and the regulation of cellular homeostasis. Many Hsp90 clients are oncogenic, which has led to a decades-long effort to develop Hsp90 inhibitors that disrupt the ATP-driven cycle of Hsp90 and consequently destabilize oncogenic Hsp90 clients. Because of the clinical importance of Hsp90 inhibitors, numerous labs have been attempting to understand the Hsp90 conformational cycle on a detailed level. The Hsp90 ATPase cycle is characterized by an open-to-closed conformational transition that involves major local and global structural rearrangements. These numerous changes make it challenging to identify key residues that control the Hsp90 conformational cycle and to study this cycle on a molecular and energetic level. In Chapter 2 of my dissertation, I describe a single residue in Hsp90 that confers a striking pH-dependent ATPase activity. Using this unique feature, I generated a quantitative and predictive model that explains how this residue affects Hsp90 conformation, Hsp90 affinity for ATP, and ATPase rate.
description: In contrast to the extensive studies on the Hsp90 conformation cycle, much less is known about how Hsp90 influences client folding. The Hsp90 field has focused primarily on kinase and transcription factor clients, large proteins that have not proven amenable to detailed analysis of folding and misfolding. In Chapter 3, I establish insulin like growth factor II (IGF2) as a tractable system to study the chaperoning function of the endoplasmic reticulum Hsp90 and Hsp70 pair (Grp94 and BiP). IGF2 is a small disulfide-linked protein with a disordered C-terminal peptide extension. I find that IGF2 readily forms oligomers due to this disordered region. While BiP and Grp94 have only a modest influence on the folding of IGF2, I find that these chaperones have a much greater influence on regulating the oligomerization of IGF2.
description: The finding that BiP and Grp94 influence IGF2 oligomerization was unexpected. Therefore, I also examined a second client protein system In Chapter 4. Specifically, the E.coli L2 ribosomal protein is known to bind tightly to the bacterial Hsp90 homolog. Like IGF2, L2 contains a region that can fold as well as disordered C-terminal peptide extension. While it is unclear whether L2 oligomerization plays an important role in how HtpG recognizes this client, I have identified regions on both HtpG and L2 that mediate their interaction.
New nanocomposite materials from kaolinite as a mineral precursor.
Creators: name: Tunney, James J.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Chemistry, Organic.

description: New thermally resistant nanocomposite organokaolinite material have been prepared and characterized. The preparation method for these materials generally involves first expanding the kaolinite interlayers with an intercalating agent such as dimethyl sulfoxide, followed by reaction with a given reagent in the interlayer space of the expanded kaolinite. In many cases the interlamellar surface of kaolinite was chemically modified through the grafting of organic units on the mineral surface. One new class of organokaolinite material was proposed to be formed through the interlayer condensation reaction between an alcohol group of the attacking species and an interlayer surface aluminol group of the kaolinite host to form Al-O-C linkages between the mineral and the organic components. In this manner, new chemically robust methoxy and ethylene glycol functionalized organokaolinites were prepared, with basal spacing of 8.2 A and 9.4A respectively. Furthermore, a new family of oxyethylene (-OCH$\sb2$CH$\sb2$-) based organokaolinite material was prepared and characterized. These materials include the species 15-crown-5 and 18-crown-6 as well as polyethylene glycol chains (MW 3400) which have been successfully incorporated into the interlayers of kaolinite. The products exhibit well defined basal spacings ranging from 10.8 Ato 11.2 A, indicative of a 3.6-4.0 A, layer expansion due to a flattened monolayer arrangement of the oxyethylene units. The materials were generally stable up to temperatures greater than 250$\sp\circ$C in both nitrogen and air atmospheres, but the oxyethylene component could be leached out in refluxing water. Finally, some promising exploratory work involving the functionalization of the interlamellar surface of kaolinite with aminoalcohols, carboxylic acid derivatives and other reagents is presented.
The optics and applications of graphene oxide
Creators: name: Zheng, Xiaorui
Publisher: name: Swinburne
Year: 2024

description: Civilisations are advanced by both incremental developments, such as miniaturisation, and quantum leaps such as the Industrial Revolution. Silicon, as the principal material for semiconductor devices, has not only dominated the material science, but shaped the engineering counterparts. However, the use of silicon in photonics has been restricted due to its large footprint, opaqueness, and time-consuming manufacturing.

This thesis presents innovative research on the optics and applications of graphene oxide and reduced graphene oxide by using the direct laser printing method, providing indispensable for the next generation highly efficient, integratable, ultralight weight, and ﬂexible optical systems towards various multidisciplinary applications.
title: Justice and Justification
title: Historical Renderings of Republic of Austria v. Altmann, National Self-Identities, and the Framing of American Moral Authority on the Global Stage
titleType: Subtitle
Creators: name: Trout, Elias Brandfonbrener
Publisher: name: Brandeis University
Year: 2021
Subjects: Republic of Austria v. Altmann; Holocaust restitution; national myth

description: Maria Altmann, the plaintiff of the Supreme Court case Republic of Austria v. Altmann, sought to recover six of her family's Nazi-looted Gustav Klimt paintings. Having belonged to the upper echelons of Viennese society in the interwar period, these paintings came to represent national ownership of Maria's Jewish heritage: if Austria was forced to return the artworks, their national myth would falter. Certain voices within the United States, meanwhile, would bolster their existing sense of self (and their global standing) by claiming to fight for a neutral, 'objective,' and individualist value set upon the world stage.
description: This project begins with an historiographical analysis of the American state's views towards Holocaust restitution (from the early postwar years to the early 2000's) before examining Maria Altmann's life and legal battle, and her narrative's particular appeal towards U.S. audiences. The paper then moves towards each legal team's strategies and rhetoric as well as the Supreme Court's various rulings. Finally, respective investigations of the journalistic coverage and popular cultural representations of Mrs. Altmann's narrative elucidate how the subversive elements within one woman's story became subject to mass interpretation and integrated into existing cultural thought.
A different shade of blue. Peacekeeping by confrontation: The Canadian contingent in Cyprus, 1964-1975.
Creators: name: Gravelle, Robert J. A. R.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: History, Modern.

description: The study of conflict management in the post war period has encompassed various aspects, including the debates over the usefulness of international attempts in the maintenance of peace and security. Since 1945, Canada has been involved in all major United Nations peacekeeping missions including observation operations from 1945-1956, peacekeeping operations from 1956 to the present, and peace enforcement operations since 1991. The Canadian literature on peacekeeping missions has centred on foreign and defence policy questions and their influence on international affairs from a Canadian perspective. To fully appreciate the nature of peacekeeping operations in their foreign and defence policy contexts, we need to understand better how individual operations function, the principal problems encountered, and the way such operations have ended over time. This study of the United Nations Force in Cyprus (UNFICYP) is an analysis of a Canadian military operation and the evolution of peacekeeping from 1964-1975, with emphasis on the crucial 1974 period, which witnessed the Canadian Contingent's leading role in redefining the concept and practice of peacekeeping in Cyprus. Overnight it went from peacekeeper in an inter-communal situation to a peacemaker in a full scale war. The development of confrontational tactics in pressing cease-fires and in stabilizing the main confrontational area of Nicosia by declaring UN protected areas and the willingness to use force to retain these areas, was a major innovation in its modus operendi. The rendering of humanitarian assistance to both communities during the war and the protection of more than 200,000 refugees also necessitated the UN force to adopt new methods of providing aid. The UN presence was instrumental in saving countless lives and preventing a number of atrocities. The involvement of the UN through its presence in the cease-fire negotiations and the delineation of cease-fire lines underlined the important role and influence of the force that led to the ending of hostilities between the Turkish army and the Greek Cypriot National Guard. The leading role and influence which the Canadian Contingent exerted in UNFICYP, resulting in changing the concept and practice of peacekeeping in Cyprus, has been to this point overlooked.
Functional and Evolutionary Diversification of Metal-dependent HD-domain Phosphodiesterases
Creators: name: Sun, Sining
Publisher: name: Brandeis University
Year: 2022
Subjects: c-di-GMP
c-GAMP
Cas3
HD-domain
HD-GYP
phosphodiesterase

description: Cyclic mono- and di-nucleotides are essential signaling molecules involved in many cellular processes. Cellular levels of cyclic nucleotides are fine-tuned by metal-dependent phosphodiesterases (PDEs), such as the histidine-aspartate (HD)-domain proteins. The large histidine-aspartate (HD)-domain protein superfamily contain metalloproteins that share common structural features but catalyze vastly different reactions. This thesis focuses on the characterization of three HD-domain PDEs: i) the tandem domain HD-[HD-GYP] PDE, VCA0681 (V-cGAP1), ii) the prototypical single domain HD-GYP PDE, VCA0931 (V-cGAP3), both from the human pathogen Vibrio cholerae (Vc), and iii) the HD-domain Cas3 nuclease, which degrades foreign DNA in Type I clustered regularly interspaced short palindromic repeats (CRISPR)-associated systems (Cas) system.Cellular levels of cyclic dinucleotides (CDNs) are regulated by EAL and HD-GYP proteins. Although both protein families were discovered almost at the same time, HD-GYPs are less well structurally and functionally characterized. There is an increasing number of annotated HD-GYP proteins, highlighting their importance in the regulation of CDNs. VCA0681 was previously identified as an HD-GYP PDE that showed significant hydrolysis of c-di-GMP and 3’3’c-GAMP in Vc. In chapter 2, we identified SO3491 as a homolog of VCA0681 and characterized both proteins with respect to their catalytic properties, range of metal ions and substrates. We also performed phylogenetic analyses so as to examine the distribution and functional relationships of the HD-[HD-GYP]s to the rest of HD-GYPs.
description: VCA0931 (V-cGAP3), a prototypical single domain HD-GYP from Vc, colocalizes phylogeneticaly with VCA0681 (V-cGAP1). However, the extant chemical makeup and steady-state parameters of the VCA0931 cofactor remain little explored. The simple architecture also makes it an ideal model for examining chemical roles of HD-GYP conserved residues. In chapter 3, we carry out an in-depth characterization of VCA0931 on its metal and substrate selectivity, as well as roles of conserved protein motifs.
description: Chapter 4 describes the characterization of Type I Cas3 nucleases. The nuclease Cas3 is also an HD-domain PDE, but little is known about the metallocofactor requirements for optimum activity. We map a promiscuous metal ion cofactor profile for the Cas3 from Thermobifida fusca (Tf) and show that Fe is not inhibitory as initially thought. We also explore the ability of Cas3 to hydrolyze cyclic mononucleotides and compare that activity to the homologous Conserved virulence factor A (CvfA), an HD-domain protein hydrolyzing 2’3’-cylic phosphodiester bonds at RNA 3’-termini.
Genetic Counselors’ role in maternal PKU: Patient and Genetic Counselor perspectives
Creators: name: Bellerose, Holly
Publisher: name: Brandeis University
Year: 2011
Subjects: phenylketonuria
genetic counseling
maternal PKU

description: Phenylketonuria (PKU) is a rare autosomal recessive disorder which causes toxic build up of phenylalanine, leading to microcephaly, seizures, severe intellectual disability and behavioral problems in untreated individuals. Maternal PKU results in the risk to have offspring with microcephaly, congenital heart defects, cognitive disability and low birth weight. The goal of this study was to examine the role that genetic counselors currently have in the care of pregnant women with PKU and how that informs us about the potential opportunities genetic counselors may play in the care of these women. We recruited genetic counselors who have been involved in the care of women with PKU as well as women with PKU who have had a prior pregnancy, to complete two separate anonymous, online surveys, which included both multiple choice and open ended questions. Thirty-five genetic counselors and sixteen women with PKU responded to the surveys. Women with PKU presented to genetic counseling in a variety of ways, most often related to maternal PKU, which was observed in both surveys. During genetic counseling visits for non-maternal PKU related indications, maternal PKU was discussed, indicating that genetic counselors are educated about and currently provide information about PKU and maternal PKU effects. The majority of women with PKU that genetic counselors reported they had seen were seen pre-conception or prenatally and not postnatally. The majority of genetic counselors felt that women with PKU should be seen by genetic counselors to discuss risks related to maternal PKU and the risk of PKU in offspring. Women with PKU reported positive responses to experiences with genetic counselors. Overall, our study suggests that genetic counselors can fill an important supportive and education role in the care of women with PKU surrounding their pregnancies.
Αντρέας Δημητριάδης, Σαιξπηριστής, άρα περιττός. Ο ηθοποιός Νικόλαος Λεκατσάς και ο δύσβατος δρόμος της θεατρικής ανανέωσης στην Ελλάδα του 19ου αιώνα, ΠΕΚ, Ηράκλειο 2006
Creators: name: Σπάθης, Δημήτρης
Publisher: name: Σκηνή
Year: 2010

description: Βιβλιοπαρουσίαση.
description: Σκηνή, No 1 (2010)
Σκηνοθέτης-Ηθοποιός-Σχολή
Creators: name: Vitez (μτφ. Νικηφόρος Παπανδρέου), Antoine
Publisher: name: Σκηνή
Year: 2010

description: Υπό διαμόρφωση
description: Σκηνή, No 1 (2010)
Effects of elevated temperatures on electrochemical processes and electrocatalysis and adsorption in the oxygen evolution reaction at alpha and beta lead dioxides.
Creators: name: Ho, Chi Keung (Jimmy).
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Chemistry, Analytical.

description: The first part of the thesis is concerned with the problem of temperature dependence of the Tafel slope for various electrochemical processes including the cathodic H$\sb2$ and anodic O$\sb2$ evolution reactions at Au, Pt and Ni in 0.2 N NaOH aqueous solutions at elevated temperatures up to 473 K by means of steady-state polarization experiments. It is found that the commonly assumed representation of the Tafel slope, b, as b = RT/$\beta$F with $\beta$ a constant, often equal to 0.5, is not followed, i.e. $\beta$ is dependent on T. Several examples of this unconventional behaviour of b on temperature are provided in this thesis. The effect of temperature on the surface processes of oxide film formation and reduction in both acid and alkaline aqueous solutions is also examined by means of cyclic voltammetry experiments at temperatures as high as 529 K. In addition to the expected behaviour, such as the higher is the temperature the larger is the rate of reaction, the processes also become more reversible. Experimental examples are provided in this thesis. The second part of the thesis is about the anodic O$\sb2$ evolution reaction at the two "allotropic" forms of lead dioxide, $\alpha$- and $\beta$-PbO$\sb2$ in 1 N HClO$\sb4$ aqueous solutions. The existence of these two forms of PbO$\sb2$ provides a rare opportunity of examining the structural effect in electrocatalysis and kinetics of the O$\sb2$ evolution process. Significant differences between the dimorphs are observed both in the kinetics and the adsorption behaviour of the O and OH intermediates of the reaction. Both potential-relaxation transients, following prior current interruption, and a.c. frequency-response spectroscopy are used in deriving the adsorption behaviour of the reaction intermediates, both H and O/OH species.
Staff Orientation Effectiveness and Implementation at Jewish Summer Camps & the Role of the Counselor-in-Training Program
Creators: name: Goldberger, Zachary
Publisher: name: Brandeis University
Year: 2022
Subjects: Employees
Jewish Studies
Training and Development

description: All summer camps go through an accreditation process, and an integral part of what the American Camping Association (ACA) looks for when accrediting a camp is how they train their staff through what is widely called Staff Orientation. Each camp structures its orientation differently, to tailor it to the mission of the camp and the goals for the overall staff and specific roles. While staff orientations are used at all camps accredited by the ACA, there is a lack of academic writing and analysis of camps’ orientation and intentional staff education. The purpose of this thesis is to take a deep look inside two camp orientations, those of Tamarack Camps and URJ OSRUI, to highlight the core pillars and compare their differences, including schedules, themes, and intentionally of certain content. Along with staff orientation, many camps have a Counselor-in-Training (CIT) program to prepare participants for their future roles as camp staff. I also look at the makeup of each camps’ CIT programs, as well as its efficacy in training leaders at camp, transferring learned skills back home, and preparing the participants to make a natural progression to staff the following year. My findings conclude with recommendations for camps to elevate the effectiveness of their staff trainings. I propose a new learning structure for camps that blends staff orientation and the schedule of CIT programs for a prolonged staff learning that occurs during camp and when staff return home.
Ο θάνατος του ηθοποιού στο έργο του Έντουαρντ Γκόρντον Κρέιγκ
Creators: name: Ευκλείδης, Αλέξανδρος
Publisher: name: Σκηνή
Year: 2010

description: Υπό διαμόρφωση
description: Σκηνή, No 1 (2010)
Theoretical aspects of unimolecular gas reactions.
Creators: name: Gill, E. Kerry.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1959
Subjects: subject: Chemistry, Physical.

description: A brief review is made of the various older theories of unimolecular reactions and then the present situation is examined with particular attention to the theory of N. B. Slater. The assumptions implicit in the different reaction models are made clear and the model of Hinshelwood, Kassel, Rice and Ramsperger (HKRR) is contrasted with that of Slater. Molecular vibration theory is sketched and it is shown how the Wilson FG matrix method may be conveniently adapted to the calculation of the Slater parameters. Both the HKRR and Slater theories are tested on the experimental data for the decompositions of N2O, O3, H2O 2, CH3CH2Cl and more approximately in the case of N2O5 and C2H6. Slater's calculations on the isomerization of cyclopropane are discussed. From the results of these calculations certain deductions are made regarding the nature of a reacting species and especially the possibilities for energy transfer between normal modes. At the same time, a number of inadequacies in the Slater theory, hitherto not appreciated, have become evident and these lead to a critical evaluation of the entire theory. Through the use of an electronic computer in the ethyl chloride calculations there has evolved a systematic approach to the standard problem of adjusting potential constants to produce a desired set of frequencies. Certain considerations in the choice of program and the form in which the problem is submitted to the computer have become apparent and are fully discussed.
Dissecting the conformational equilibrium of Src kinase using single-molecule FRET
Creators: name: Chen, Liuyu
Publisher: name: Brandeis University
Year: 2024

description: Kinases are responsible for the posttranslational phosphorylation of amino acid residues. Src non-receptor tyrosine kinases belong to the human kinase family. Src and Src family kinases were intensively investigated due to their malignant transformation and oncogenesis characters. Published crystal structures and biochemical studies indicate that Src has open and close conformation. And phosphorylation sites Y419 and Y530 are essential regulation sites responsible for the conformational change and kinase activity of Src. However, a quantitative analysis of Src regulation and conformation equilibrium has still not been conducted.\r Here we set about to provide detailed kinetic analysis and insight into conformation equilibrium for Src. As a starting point, I did ATP-NADH coupled enzymatic assays and Western blots on Src, Src catalytic domain, and phosphorylation sites mutants to provide detailed kinetic schemes for the regulation of Src. The results give quantitative information about the effect of phosphorylation sites on Src activity. Our data indicate that Src activity is not simply regulated by “on” and “off” switches corresponding to the open and close conformation. We further developed single-molecule FRET experiments to dissecting the conformational opening/closing equilibrium of Src. The FRET data suggest that Src may have an additional structure between open and close. Coupling the observed kinetic data with conformational information gives a comprehensive understanding of Src regulation.
(Κατα)χρήσεις της θεωρίας: με αφορμή μια «ξένη» Ηλέκτρα
Creators: name: Παπάζογλου, Ελένη
Publisher: name: Σκηνή
Year: 2011

description: Ένα από τα παράδοξα της ελληνικής θεατρικής ζωής είναι ότι, συχνά, οι άνθρωποι του θεάτρου, σκηνοθέτες και ηθοποιοί αλλά, πάνω από όλους, οι κριτικοί, αποφαίνονται για τις «αλήθειες» του αρχαίου δράματος, και δη του τραγικού, με μεγαλύτερη αρχαιογνωστική αυτοπεποίθηση από ό,τι οι θεωρητικοί — και με βάση αυτές τις «αλήθειες» χτίζουν και κρίνουν παραστάσεις. Η κριτική αντίδραση στην Ηλέκτρα του Σοφοκλή που σκηνοθέτησε ο Πέτερ Στάιν για το Εθνικό Θέατρο, το καλοκαίρι του 2007, αποτελεί απολύτως αντιπροσωπευτικό «παράδειγμα εργασίας». Όχι επειδή ήταν μια παράσταση βαθιάς «ετερότητας» — ακριβώς το αντίθετο. Επειδή η παγίωση κάποιων «αληθειών» περί το τραγικό, «αληθειών» που κατέκλυσαν την κριτική της συγκεκριμένης παράστασης, μας κάνει συχνά να χάνουμε το τροπικό δάσος (των τραγικών δυνατοτήτων) για το απολιθωμένο δέντρο (ενός τραγικού κανόνα). Στο πλαίσιο των αρχαιογνωστικών σπουδών, αυτό το δάσος αναδεικνύεται πυκνότατο, σχεδόν δυσδιάβατο: η επισκόπηση της σχετικής βιβλιογραφίας για τη σοφόκλεια Ηλέκτρα, και μια σύντομη αναδρομή στη μεταγενέστερη πρόσληψή της θα δώσει έναν αντιπροσωπευτικό δείκτη του μεγάλου εύρους των τραγικών δυνατοτήτων που η θεωρία επιτρέπει — παρόλο που ούτε διαθέτει, ούτε διεκδικεί, ούτε προαπαιτεί την «ποιητική άδεια» της καλλιτεχνικής δημιουργίας.
description: Σκηνή, No 2 (2011)
La déconstruction de la femme-nature.
Creators: name: Benson, Michelle.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Women's Studies.

description: Ce mémoire de maîtrise se veut une lecture critique des textes rediges par l'anthropologue francaise Nicole-Claude Mathieu sur une periode de 20 ans et reunis sous le titre L'anatomie politique publie en 1991. Il s'agit d'un examen de l'entreprise scientifique de Mathieu, c'est-a-dire sa deconstruction de la femme-nature contestant l'opposition structurale homme-femme, nature-culture par le biais des categories sexe-genere pour donne lieu a la conception d'une nouvelle epistemologie visant a rendre compte de l'asymetrie au niveau des rapports entre les sexes. Toutefois, l'orientation des travaux de Mathieu vers une theorie qui valorisait la specificite culturelle mene ultimement a l'occultation du biologique. La conclusion propose qu'a l'avenir, il vaudrait mieux s'abstenir de construire un discours feministe a partir des fondements de la valeur nature-culture. Les faiblesses de cette approche sont mises en evidence dans le questionnement sur l'efficacite operative de cette dichotomie.
title: How can doctors avoid bringing the coronavirus home?
title: Comment les médecins peuvent éviter de ramener le coronavirus à leur domicile ?
Creators: name: Adnine, Anass
Publisher: name: Revue Marocaine de Rhumatologie (RMR)
Year: 2020

description: Le virus de la maladie COVID-19 est un nouveau virus. Il se propage par les gouttelettes respiratoires d’une personne infectée à d’autres personnes avec lesquelles elle a des contacts étroits. Le virus peut survivre sur différentes surfaces, mais il peut être détruit par la plupart des produits désinfectants virucides.
description: Le virus de la maladie COVID-19 est un nouveau virus. Il se propage par les gouttelettes respiratoires d’une personne infectée à d’autres personnes avec lesquelles elle a des contacts étroits. Le virus peut survivre sur différentes surfaces, mais il peut être détruit par la plupart des produits désinfectants virucides.
Observer pour agir: Une étude comparative de la facilitation motrice liée à l'observation, l'imagerie et l'imitation d'actions dans le vieillissement normal et la maladie de Parkinson
Creators: name: Léonard, Guillaume
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Health Sciences, Recreation.

description: L'objectif du présent travail était de déterminer et de comparer le patron de modulation de l'excitabilité corticomotrice lié à l'observation, l'imagerie et l'imitation d'actions chez les jeunes âges de moins de 30 ans (n=21), les personnes âgées de plus de 55 ans (n=19) et les personnes atteintes de la maladie de Parkinson (MP) (n=11). L'action présentée sur un écran d'ordinateur 17" illustrait la main d'une personne coupant une pièce de matériel à l'aide d'une paire de ciseaux. Les potentiels moteurs évoqués induits à l'aide de la stimulation magnétique transcrânienne étaient mesurés dans le premier interosseux dorsal (FDI) et dans le court abducteur du cinquième doigt (ADM) dans quatre conditions: (1) repos, (2) observation de l'action, (3) imagerie motrice de l'action et (4) imitation de l'action. Chez les jeunes participants, l'imitation produisait la plus grande facilitation lorsque comparée au repos, suivi de l'observation et de l'imagerie qui induisaient des facilitations comparables. Ces facilitations étaient sélectives au muscle FDI puisque, dans le muscle ADM, seule l'imitation était associée à une facilitation corticomotrice. Chez les personnes âgées, le patron de facilitations était relativement semblable à celui observé chez les jeunes, à la différence que les facilitations notées dans le FDI étaient aussi présentes dans l'ADM. Quant aux patients avec la MP, les facilitations associées aux conditions d'observation et d'imagerie se sont avérées variables et inconsistantes par rapport aux personnes contrôlés du même âge. La diminution de la sélectivité chez les personnes âgées ainsi que les déficits des facilitations clicz les personnes atteintes de la MP cadrent bien avec la théorie de simulation motrice proposée par Jeannerod (2001). En effet, de tels déficits sont similaires à ceux observés chez ces populations lors de l'exécution réelle (notamment une diminution de la dextérité manuelle chez les personnes âgées et des troubles d'activation motrice chez les personnes atteintes de la MP) et appuient donc l'hypothèse selon laquelle il existerait une équivalence au niveau neural entre les états associés à la production d'actions motrices, que celles-ci soient exécutées réellement, simplement observées ou simulées mentalement.
Analyse comparative du droit législatif en matière de prostitution
Creators: name: Tremblay, Yves Junior
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Law.
subject: Women's Studies.
subject: Sociology, Criminology and Penology.

description: Ce travail de maîtrise est une analyse comparative du droit législatif en matière de prostitution. Plus précisément, on tente de savoir si les systèmes législatifs en matière de prostitution ont une influence sur la dynamique prostitutionnelle mondiale. Trois parties composent cette thèse de maîtrise. Un premier chapitre explorant la situation prostitutionnelle mondiale. Dans ce chapitre on y explique les deux principales causes de l'expansion de la prostitution à travers le monde: la mondialisation néo-libérale et la libéralisation de la sexualité. Dans le deuxième chapitre il y est expliqué en quoi différent les quatre différents systèmes législatifs en matière de prostitution (règlementariste, prohibitionniste, abolitionniste et néo-abolitionniste). Alors que le dernier chapitre est une analyse comparative de la situation prostitutionnelle dans quatre pays distincts: les Pays-Bas, la France, la Suède et le Maroc. L'auteur arrive à la conclusion que les systèmes législatifs ont une certaine influence sur la dynamique prostitutionnelle mondiale. Tant en Suède qu'aux Pays-Bas, la prostitution est influencée par le système législatif alors qu'au Maroc et en France, ce n'est pas tant les systèmes législatifs qui ont de l'incidence sur la dynamique prostitutionnelle, c'est plutôt la volonté politique d'appliquer ces mêmes systèmes qui est le facteur déterminant!
«Θέλγητρα εταίρος χρυσολάτριδος»: ζητήματα δραματουργικής και σκηνικής παρουσίασης της πορνείας στο ελληνικό θέατρο του 19ου αιώνα
Creators: name: Ριτσάτου, Κωνσταντίνα
Publisher: name: Σκηνή
Year: 2011

description: Μέσα στο λίγο πολύ ομοιογενές περιβάλλον των ηθικά άμεμπτων Ελληνίδων του εγχώριου δραματολογίου του 19ου αιώνα, προβάλλουν τα πορτρέτα γυναικείων προσώπων, που αν μη τι άλλο «σκανδαλίζουν» ακόμα και τον σημερινό μελετητή: ανυποψίαστες «ιερόδουλες» αφιερωμένες στην πάνδημο Αφροδίτη, εξιδανικευμένες ή «χρυσολάτριδες» εταίρες, «κοκότες» και «παστρικές» ή «ιέρειες της χαράς και της ηδονής». Οι έλληνες δραματουργοί διασταυρώνονται εδώ με τα έργα των ευρωπαίων συναδέλφων τους, αλλά φροντίζουν επιμελώς να επικαλύπτουν τις «ξενικές» επιδράσεις με έναν ιδιαίτερα διαδεδομένο, για τις εγχώριες ανάγκες, τρόπο: τα δράματά τους κρατούν ισχυρούς δεσμούς με την αρχαιοελληνική κληρονομιά. Όταν ετούτοι οι δεσμοί καταλύονται και οι γυναίκες ελευθέρων ηθών προσγειώνονται στη σύγχρονη πραγματικότητα τα έργα συναντούν ανυπέρβλητες δυσκολίες, ιδιαίτερα κατά τη σκηνική τους παρουσία.
description: Σκηνή, No 2 (2011)
Étude théorique de l'électrophorèse de piégeage du complexe streptavidine-ADN.
Creators: name: Desruisseaux, Claude.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Biophysics, General.

description: Dans le cadre du programme international d'analyse du genome humain, nombres d'efforts sont actuellement deployes pour augmenter le nombre de bandes qui peuvent etre lues par experience d'electrophorese. Ici, nous etudions comment le fait d'ajouter une grosse proteine neutre (la streptavidine) a un des bouts des molecules d'ADN va modifier leur dynamique quand on en fait l'electrophorese dans un gel. Un modele analytique base sur une equation de diffusion a ete developpe et montre des resultats qui sont en accord qualitatif avec les simulations numeriques et avec les experiences. Ce modele est le seul qui permet d'etudier le coefficient de diffusion, ce qui nous permet d'evaluer le facteur de resolution. En plus de ce modele theorique, des simulations ont ete effectuees et nous ont permis de mieux comprendre comment les processus de piegeage et de depiegeage vont influencer la dynamique du systeme en champs constants et en champs pulses. Nous prevoyons ainsi certains effets anomaux qui pourront etre verifies sous peu. De plus, les resultats de nos simulations nous suggerent de nouvelles methodes pour augmenter l'efficacite de l'electrophorese de piegeage.
Βασικοί προβληματισμοί γύρω από τη σκηνογραφία και την ενδυματολογία στη ρωσική πρωτοπορία: συνοπτική παρουσίαση θεωρητικών κειμένων της εποχής
Creators: name: Μάντακα, Χρύσα
Publisher: name: Σκηνή
Year: 2011

description: Αντίθετα από τους απλουστευτικούς ισχυρισμούς ιστορικών, οι οποίοι αντιμετώπισαν τη σοβιετική κουλτούρα της δεκαετίας του 1920 ως μια απλή περίοδο ηγεμονίας του σουπρεματισμού και του κονστρουκτιβισμού ή ως απλή σύγκρουση ανάμεσα στις διάφορες πρωτοπορίες και στον ηρωικό σοσιαλιστικό ρεαλισμό, η καλλιτεχνική ζωή των αρχών του 20ού αιώνα υπήρξε πολύ πιο σύνθετη και πολύ πιο πέρα από αυτές τις αντιθέσεις. Ο χώρος της σκηνογραφίας και της θεατρικής ενδυματολογίας διακρινόταν και αυτός από πολυφωνία, αποτέλεσμα των πολύ διαφορετικών και σύνθετων παραγόντων και τάσεων που τις επηρέαζαν. Κοινό, ωστόσο, σημείο στις εικαστικές αναζητήσεις, τάσεις και προτάσεις στη σκηνογραφία και στην ενδυματολογία, όπως μαρτυρούν, στην πλειοψηφία τους, τα σωζόμενα ντοκουμέντα, αποτελούσε η πρόθεση των καλλιτεχνών να υπηρετήσουν τις σκοπιμότητες ενός «συνολικού» έργου τέχνης, το οποίο δεν απευθυνόταν πλέον σε ένα ελιτίστικο και ήδη καλλιεργημένο θεατρικά κοινό, αλλά στον νέο, προλετάριο θεατή που κατέκλυσε τις θεατρικές αίθουσες και τις δημόσιες πλατείες. ΤΕΧΝΙΚΗ ΣΥΜΒΟΥΛΗ: Στις υποσημειώσεις του άρθρου συχνά συμπεριλαμβάνονται παραπομπές σε εικόνες, οι οποίες φιλοξενούνται σε διάφορες ιστοσελίδες. Αν πατήσετε τους σχετικούς συνδέσμους ενώ διαβάζετε το κειμενο διαδικτυακά, τότε οι ιστοσελίδες ανοίγουν στο ίδιο παράθυρο με το κείμενο, και θα αναγκαστείτε να πισωγυρίζετε σε αυτό. Είναι προτιμότερο, να κατεβάσετε το άρθρο στον υπολογιστή σας και να το διαβάσετε τοπικά: σε αυτήν την περίπτωση, οι σύνδεσμοι θα ανοίγουν σε ξεχωριστό παράθυρο, οπότε θα μπορείτε να έχετε παράλληλη πρόσβαση στο κείμενο και τις εικόνες του.
description: Σκηνή, No 2 (2011)
Cloning and characterization of two protein tyrosine phosphatases (PTPases) from embryonic and adult murine sources.
Creators: name: Marshall, Trudy D.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Biology, Molecular.

description: A PCR strategy was used to amplify novel sequences residing between two degenerate protein tyrosine phosphatase (PTPase) -specific primers. Partial Class I and II clones were isolated from a library constructed with this P19 stem cell derived-cDNA. The predicted amino acid sequence of these PCR fragments revealed sufficient identity with the PTPase consensus to indicate that a region from two individual PTPases had been cloned. Northern analysis of the Class II or PTP2 PTPase revealed a 5 Kb mRNA in all mouse tissues and cell lines examined, while the mouse CAP-1 (Class I) gene was found to be expressed as 5 and 7 Kb mRNA transcripts in a variety of mouse tissues. CAP-1 PTPase cDNAs have been cloned from messenger RNA derived from mouse kidney and embryonal carcinoma cells. The composite cDNA contains an open reading frame which encodes 942 amino acids. The N-terminal portion of the predicted protein (M$\sb{\rm r}$ = 107,000) shares 30-37% identity with homologous regions in the cytoskeletal associated proteins, band 4.1, ezrin, moesin, radixin, and talin. This PTPase has been termed CAP-1 for cytoskeletal associated protein related PTPase. The C-terminal phosphatase domain is 33-41% identical to catalytic domains of known PTPases. The bacterially expressed GST/CAP-1 fusion protein preferentially removes phosphate moieties from tyrosine residues. CAP-1 exhibits a specific pattern of transcription in several tissues, that is, in leg muscle as well as heart and brain. In adult leg muscle, CAP-1 is expressed as two distinct transcripts which are approximately 500 bp shorter than that found in other murine tissues. The corresponding skeletal muscle cDNAs were cloned to elucidate the mechanism by which the different mRNAs arise. The composite leg muscle CAP-1 (LMCAP-1) cDNA, with leg muscle-specific sequence at the 5$\sp\prime$ end, predicts a truncated LMCAP-1 protein which lacks part of the protein 4.1 homology region. This CAP-1myc fusion was transiently expressed in COS-1 cells to elucidate the localization and possible function of CAP-1. A CAP-1myc specific protein close to the predicted molecular weight (110-120 kDa) was immunoprecipitated from these metabolically labeled cells. Concurrently, indirect immunofluorescence with an $\alpha$myc antibody revealed a punctate, non-nuclear pattern of exogenous CAP-1myc expression in transfected COS-1 cells. Morphological changes such as the "giant cells" observed in several CAP-1myc/pMT21- and CAP-1myc/pECE-generated NIH 3T3 clones, appear unique to CAP-1, suggesting that this phenomenon is a result of the dephosphorylation of a cytoskeleton/membrane protein found normally associated with this enzyme.
Κατερίνα Αρβανίτη, Η αρχαία ελληνική τραγωδία στο Εθνικό Θέατρο: Θωμάς Οικονόμου, Φώτος Πολίτης, Δημήτρης Ροντήρης, τ. Α΄, Νεφέλη, Αθήνα, 2010, σ. 296 + 93 εικ.
Creators: name: Γλυτζουρής, Αντώνης
Publisher: name: Σκηνή
Year: 2011

description: Βιβλιοκρισία.
description: Σκηνή, No 2 (2011)
Σκηνική πράξη στο μεταπολεμικό θέατρο. Συνέχειες και ρήξεις. Διεθνές επιστημονικό συνέδριο, αφιερωμένο στον Νικηφόρο Παπανδρέου. Ένας απολογισμός
Creators: name: Δελβερούδη, Ελίζα Άννα
Publisher: name: Σκηνή
Year: 2011

description: Συνοπτική επισκόπηση του συνεδρίου που διοργάνωσε το Τμήμα Θεάτρου, προς τιμήν του Νικηφόρου Παπανδρέου, το φθινόπωρο του 2010.
description: Σκηνή, No 2 (2011)
Η διεθνής έκθεση σκηνογραφίας της Πράγας (Prague Quadrennial) και η συμμετοχή του Τμήματος Θεάτρου ΑΠΘ
Creators: name: Καρακώστα, Λίλα
name: Καραδελόγλου, Μαρία
Publisher: name: Σκηνή
Year: 2011

description: Από την επικαιρότητα του Τμήματος Θεάτρου.
description: Σκηνή, No 2 (2011)
Φεστιβάλ Φιλίππων–Καβάλας. Η συμμετοχή του Τμήματος Θεάτρου ΑΠΘ
Creators: name: Μπουσουλέγκα, Αλεξάνδρα
name: Υφαντίδου, Ράνια
Publisher: name: Σκηνή
Year: 2011

description: Από την επικαιρότητα του Τμήματος Θεάτρου.
description: Σκηνή, No 2 (2011)
Reliance on science: An examination of the newsprint media's construction of DNA technology regarding innocence and wrongful conviction
Creators: name: Veld, Douglas N
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Sociology, Criminology and Penology.

description: Wrongful convictions remain an understudied problem in Canada. With the advent of recent technological advances in the form of forensic DNA analysis, newsprint media agencies have served as a medium for questioning the fallibility of the criminal justice system while raising public awareness of erroneous convictions. The social constructionist theoretical perspective provides the foundational underpinnings of a qualitative content analysis surrounding the print-news coverage of three Canadian wrongful conviction cases: David Milgaard, Guy Paul Morin and Gregory Parsons. Findings indicate disparity in the amount, extent, nature and content of coverage amongst wrongful conviction cases and between national and local coverage. The data suggests that for an individual to conclusively establish factual innocence, DNA technology must not only exonerate the wrongfully convicted individual but must also implicate the 'real' perpetrator. These results suggest the newsprint media is perpetuating a 'hierarchy of wrongful convictions' based on an individual's ability to conclusively establish their factual innocence through the utilization of forensic DNA analysis.