cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Union County Mosquito Extermination Commission report of work done 1928
Creators: name: Savoye, R. G.
name: Keeney, Caldwell B.
name: Bauer, Jacob L.
name: Dengler, Henry P.
name: Hopkins, John T.
name: Randolph, William H.
name: Vars, Alexander W.
Publisher: name: No Publisher Supplied
Year: 1928

description: A yearly series of reports from the Union County Mosquito Extermination Commission. The reports cover finances, inspections, drainage, oiling, and salt marsh, inland, and educational work regarding the extermination and control of mosquitoes in the different towns and districts of Union County, New Jersey.
Guavina micropus Ginsburg 1953
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Eleotridae
Guavina
Guavina micropus

description: Guavina micropus Ginsburg 1953. Pacific Guavina; Guavina del Pacífico
Vouchers: (other collections) MCZ 30722 (1). Distribution: Eastern Pacific Ocean; from Nicaragua to northern Colombia; entering estuaries and ascending river courses; (Nicaragua) PN (Pacific); 0–6 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; DD (2010), population trend unknown. Literature: Robertson & Allen (2015: 2650; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 35; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 34, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Chilota mahunkai Zicsi 1993
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Opisthopora
Acanthodrilidae
Chilota
Chilota mahunkai

description: Chilota mahunkai Zicsi, 1993
Chilota mahunkai Zicsi, 1993b Mitt. Hamb. Zool. Mus. Inst. 90: 157.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 13, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Report of the Union County Mosquito Extermination Commission for 1929
Creators: name: Dengler, H. P.
name: Van Derwerker, R. J.
name: Collins, Roi C.
Publisher: name: No Publisher Supplied
Year: 1929

description: A yearly series of reports from the Union County Mosquito Extermination Commission. The reports cover finances, inspections, drainage, oiling, and salt marsh, inland, and educational work regarding the extermination and control of mosquitoes in the different towns and districts of Union County, New Jersey.
Epigenetic immunosensitization of central nervous system tumors with the histone deacetylase inhibitor, LBH589, for adoptive transfer immunotherapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Rationale. Malignant melanoma commonly metastasizes to the brain, leaving clinicians with few options. Immunotherapy for metastatic brain cancer is currently a promising therapeutic modality for these patients, but much remains to be learned about the immune system in order to translate pre-clinical findings into clinical efficacy. It is likely that the successful translation of such immune-based approaches will evolve with other standard and/or novel chemotherapy regimens. Systemic chemotherapy can induce a significant decrease in tumor burden, but cancers almost always relapse. Immunotherapy gives low response rates, but objective responses are often durable and some patients are seemingly cured. Thus, there exists a strong rationale to combine standard treatment regimens with immunotherapy as long as the systemic chemotherapy regimen does not also impair the efficacy of the immunotherapy. However, since many chemotherapy drugs are targeted to the cellular machinery associated with cell division, such drugs are likely (and have been shown) to additionally interfere with the proliferation of tumor-specific T lymphocytes; an essential component of immunotherapy. We have established a subcutaneous and intracranial mouse model of primary and metastatic melanoma, respectively, for which adoptive immunotherapy provides a significant extension of survival, but does not cure these animals and requires adjuvant treatment. Such studies have demonstrated that the addition of a histone deacetylase inhibitor (HDACi), LBH589, to this immunotherapy regimen results in enhanced anti-tumor immunity and extended survival. Thus, this proposal is designed to gain a mechanistic understanding of how such epigenetic regulating drugs can act on the tumor and immune system. Our group has a significant amount of preliminary data to justify both the work and the feasibility of completing our proposed studies. Finally, these studies are directly applicable to the study and treatment of cancer and have broad ramifications for enhancing current immune-based therapeutics in the clinic. Specific Aims. We propose one specific aim that seeks to understand the biological activity and mechanism(s) by which the HDACi, LBH589 (Novartis), may enhance the anti-tumor effects of adoptive cell transfer (ACT) immunotherapy in established intracranial (i.c.) melanoma.
Report of the Union County Mosquito Extermination Commission for 1930
Creators: name: Dengler, Henry P.
name: Collins, Roi C.
name: Van Derwerker, Ralph J.
Publisher: name: No Publisher Supplied
Year: 1930

description: A yearly series of reports from the Union County Mosquito Extermination Commission. The reports cover finances, inspections, drainage, oiling, and salt marsh, inland, and educational work regarding the extermination and control of mosquitoes in the different towns and districts of Union County, New Jersey.
Report of the Union County Mosquito Extermination Commission for 1931
Creators: name: Van Derwerker, Ralph J.
Publisher: name: No Publisher Supplied
Year: 1931

description: A yearly series of reports from the Union County Mosquito Extermination Commission. The reports cover finances, inspections, drainage, oiling, and salt marsh, inland, and educational work regarding the extermination and control of mosquitoes in the different towns and districts of Union County, New Jersey.
Hemieleotris latifasciata
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Eleotridae
Hemieleotris
Hemieleotris latifasciata

description: Hemieleotris latifasciata (Meek & Hildebrand 1912) (Fig. 7L). Pygmy Sleeper; Guavinita, Guavina Enana
Vouchers: (other collections) KU 22705 (1). Distribution: Eastern Pacific Ocean; from southern Mexico to Ecuador; entering estuaries and ascending river courses; (Nicaragua) ER, PN and Ni (Pacific); 2–30 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2020), population trend stable. Literature: Villa (1982: 225; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bussing (1998: 425; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology) and Angulo (2021: 35; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 34, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
MOESM12 of Population structure and genomic inbreeding in nine Swiss dairy cattle populations
Creators: name: Signer-Hasler, Heidi
name: Burren, Alexander
name: Neuditschko, Markus
name: Frischknecht, Mirjam
name: Garrick, Dorian
name: Stricker, Christian
name: Gredler, Birgit
name: Bapst, Beat
name: Flury, Christine
Publisher: name: Figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Neuroscience
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: Additional file 12: Table S5. Correlations between F PED and F ROH and between F PED and F HOM including all animals. Table S6. Correlations between F PED and F ROH and between F PED and F HOM including only animals with PCIÂ >Â 0.95.
Chilota osornoi Zicsi & Csuzdi 2001
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Opisthopora
Acanthodrilidae
Chilota
Chilota osornoi

description: Chilota osornoi Zicsi & Csuzdi, 2001
Chilota osornoi Zicsi & Csuzdi, 2001 Ber. nat.-med. Verein Innsbruck 88: 132.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 13, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Report of the Union County Mosquito Extermination Commission for 1932
Creators: name: Van Derwerker, Ralph J.
name: Dengler, Henry P.
Publisher: name: No Publisher Supplied
Year: 1932

description: A yearly series of reports from the Union County Mosquito Extermination Commission. The reports cover finances, inspections, drainage, oiling, and salt marsh, inland, and educational work regarding the extermination and control of mosquitoes in the different towns and districts of Union County, New Jersey.
Exploring re-replication as a novel source of chromosome instability
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Eukaryotic cells must prevent inappropriate re-initiation of DNA replication from thousands of origins scattered throughout their genomes. For the past fifteen years, my work has focused on understanding how initiation of DNA replication is regulated using the budding yeast Saccharomyces cerevisiae as a model organism. My laboratory has shown that cells impose such an exquisitely tight restriction by using a multitude of overlapping mechanisms to inactivate replication proteins after origins have fired. Disrupting these mechanisms can lead to inappropriate re-replication, but the biological consequences of re-replication are completely unknown. Having developed the technology to re-replicate chromosomal regions at will, we are now uniquely positioned to test a longstanding speculation that re-replication may lead to genomic instability. This constitutes a new direction that moves us beyond our expertise in DNA replication into the fields of mitosis, chromosome segregation, and genome instability. In this proposal we focus on the connection between re-replication and chromosome instability, one of the genetic alterations widely associated with oncogenesis. Our preliminary data suggest that re-replication of a centromere may lead to chromosomal aneuploidy. Here we capitalize on this finding to propose and test the hypothesis that centromere re-replication can confuse the mitotic apparatus and lead to chromosome nondisjunction. In Aim 1, we will use an established colony color sectoring assay coupled with microarray-based comparative genomic hybridization (array CGH) to monitor the segregation pattern of a marked chromosome and quantify the frequency of chromosome nondisjunction following centromere re-replication. In Aim 2, we will directly visualize fluorescently marked chromosomes using spinning disk confocal microscopy during mitosis to investigate how re-replicated centromeres might delay the entry into or progression through anaphase. By establishing a causal relationship between re-replication and chromosome instability, we hope these studies will help secure extramural funding to support future research exploring and expanding the link between re-replication and oncogenesis.
Hymenophyllum hirsutum
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Hymenophyllum
Hymenophyllum hirsutum

description: Hymenophyllum hirsutum (L.) Sw.
MADAGASCAR: Réserve Spéciale de Manongarivo, 27 Sep. 2004, G.Rouhan et al. 270 (P00749199).
LA RÉUNION: Forêt de Mare Longue, 23 Apr. 2002, J.Y.Dubuisson HR 2002­16 (P02433298).
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 52, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
MOESM5 of High-resolution analysis of selection sweeps identified between fine-wool Merino and coarse-wool Churra sheep breeds
Creators: name: GutiĂŠrrez-Gil, Beatriz
name: Esteban-Blanco, Cristina
name: Wiener, Pamela
name: Chitneedi, Praveen
name: Aroa Suarez-Vega
name: Juan-Jose Arranz
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology

description: Additional file 5: Figure S4. Average linkage disequilibrium (LD) as a function of genomic distance between markers based on the Churra and Australian Merino 50K-Chip genotypes analyzed in this study. The LD values (y-axis), provided as Dâ   and r2, are plotted against inter-marker distance bins (x- axis). For each case, the total number of marker pairs were assigned according to their physical distance into 14 categories: < 10 Kb, 10-20 Kb, 20-40 Kb, 40-60 Kb, 60-100 Kb, 200-500 Kb, 0.5-1 Mb, 1-2 Mb, 2-5 Mb, 5-10 Mb, 10-20 Mb, 20-50 Mb or > 50 Mb.
Leptophilypnus fluviatilis Meek & Hildebrand 1916
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Eleotridae
Leptophilypnus
Leptophilypnus fluviatilis

description: Leptophilypnus fluviatilis Meek & Hildebrand 1916. Atlantic Freshwater Sleeper; Dormilón de Agua Dulce
Vouchers: UCR 0267-010 (1); other collections: UF 106911 (1). Distribution: Western Atlantic and eastern Pacific (Canal zone in Panama) oceans; from Honduras to Panama; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) GM and Es (Atlantic); 0–141 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2020), population trend unknown. Literature: Robertson & Van Tassell (2019: 4418; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 36; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 35, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Report of the Union County Mosquito Extermination Commission for 1933
Creators: name: Collins, Roi C.
Publisher: name: No Publisher Supplied
Year: 1933

description: A yearly series of reports from the Union County Mosquito Extermination Commission. The reports cover finances, inspections, drainage, oiling, and salt marsh, inland, and educational work regarding the extermination and control of mosquitoes in the different towns and districts of Union County, New Jersey.
Hymenophyllum capense Schrad., Gottingische 1818
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Hymenophyllum
Hymenophyllum capense

description: Hymenophyllum capense Schrad.
MADAGASCAR: Iaraka Maroantsetra, 19 Aug. 1968, J.­L.Guillaumet 2080 (P01314347); RNI 12 du Marojejy, 14 Oct. 1996, F.Rakotondrainibe 3365 (P00084833); RNI 12 du Marojejy, 6 Nov. 1996, F.Rakotondrainibe 3637 (P00085205); RNI 12 du Marojejy, 9 Nov. 1996, F.Rakotondrainibe 3652 (P00085221); Réserve Spéciale d’Ivohibe, 26 Oct. 1997, F.Rakotondrainibe 4253 (P00134287); PN de Ranomafana, Forêt de Vatoharanana, 5 Oct. 2000, F.Rakotondrainibe 5898 (P00212381); Forêt de Vinanitelo, au pied de la montagne d’Ambodivohitra, 26 Oct. 2000, F.Rakotondrainibe 6121 (P00212664).
SOUTH-AFRICA: Natal, coll.? (P01314296), coll.? (P01314297).
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 52, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
title: Antonin Artaud et la philosophie : l'expérience vécue de la pensée / Antonin Artaud und die Philosophie: Erlebnis des Denkens
title: Antonin Artaud and philosophie: lived experience of thinking
titleType: AlternativeTitle
Creators: name: Gonashvili, Gigla
Publisher: name: Bergische Universität Wuppertal
Year: 2024

description: Unsere Arbeit widmet sich Antonin Artaud, dessen Leben und Denken die Aufmerksamkeit zahlreicher französischer Philosophen des 20. Jahrhunderts auf sich gezogen hat. Besonders seit den 60er Jahren ist Artaud zu einem viel rezipierten Thema der zeitgenössischen Philosophie geworden, unter anderem durch die Kommentare von Derrida und Deleuze. Zunächst bekannt als Theaterschauspieler, entwickelt er später seine eigene Theaterkonzeption. In seinen Jugendjahren schreibt Artaud Gedichte und veröffentlicht kurze Essays. Im Allgemeinen kann man sagen, dass er nach einer intellektuellen Berufung strebt. Sein Leben ist von Grenzüberschreitungen geprägt; oder vielmehr weigert er sich, seine Tätigkeit und sein Leben in irgendein Gebiet einzuordnen. In seinen Briefen an Rivière präsentiert er sich als junger Mann, der mit etwas Einzigartigem konfrontiert ist. Für Artaud manifestiert sie sich im Verflechten von Existenz und Denken. Er entdeckt „Löcher“ und „Stillstände“ in seinem Denken; manchmal wird er vom Gefühl der „völligen[n] Inexistenz“ überwältigt, die in seiner Innerlichkeit auftaucht. Dennoch treibt ihn das dazu an, umso mehr auf seine Gedanken und auf das neue Wissen über sich selbst zu beharren. Er glaubt, dass er sein Denken den heftigen Schwankungen öffnen kann, die sein ganzes Wesen durchziehen: „Beben des Körpers oder der Seele – es gibt keinen menschlichen Seismographen, der es dem, der mich betrachtet, gestattet, zu einer genaueren Einschätzung meines Schmerzes zu kommen als zu der – niederschmetternden – meines Geistes.”
description: The life and thought of Antonin Artaud have attracted the attention of many French philosophers of the 20th century. Contemporary philosophy has shown interest in Artaud particularly since the 1960s, due to the comprehensive commentaries by Derrida and Deleuze. Known primarily as a theater actor, Artaud later developed his own conception of theater. Especially during his youth, Artaud wrote poems and published short essays. It can be said that he aspired to an intellectual vocation. However, his life is marked by transgressions: he refused to confine his activity and life within any particular domain. In his letters to Rivière, he presents himself as a young man confronted with something singular.What is this singularity? For Artaud, it manifests in the intertwining of existence and thought. He discovers “holes” and “interruptions” in his thinking, and even claims that from time to time he suffers from the “absolute inexistence”. He lives through his thoughts which become strangely fragmented.
Report of the Union County Mosquito Extermination Commission for 1934
Creators: name: Collins, Roi C.
Publisher: name: No Publisher Supplied
Year: 1934

description: A yearly series of reports from the Union County Mosquito Extermination Commission. The reports cover finances, inspections, drainage, oiling, and salt marsh, inland, and educational work regarding the extermination and control of mosquitoes in the different towns and districts of Union County, New Jersey.
Computational tools to identify pathways perturbed in cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Many biological processes are composed of complex signaling pathways of interacting genes. A central challenge in functional genomics is the identification of these networks leading to complex physiological phenotypes especially for disease processes such as cancer proression. Newly available high-throughput data, in which multiple genome-wide measurements are obtained for the same tissue sample, is becoming available for hundreds of patients with various cancers. UCSC is the coordinating data center for several cancer-related consortiums to collect these data for large cohorts. However, few computational tools exist to infer which pathways represent critical molecular-level perturbations underlying clinical outomes. We propose to develop a method that uses probabilistic graphical models to score known genetic pathways that are consistently altered across a panel of patients. Our objectives are to: 1. Develop a novel method to discover which genetic pathways are consistently perturbed in tumors from patient samples; and 2. Develop online components so that perturbations detected in patients can be viewed in a pathway-centric browsing system. While the focus of this proposal is to analyze of the cancer-related data collected by the UCSC data center, the proposal will develop and evaluate state-of-the-art algorithms that will provide important information for bioinformatics investigations of genome-wide perturbation data that can be extended to investigations beyond cancer.
Mechanisms that control entry into mitosis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The events of cell division are controlled by mitotic cyclins, which bind and activate cyclin-dependent kinase 1 (Cdk1). Activation of Cdk1 at the G2/M transition is tightly regulated by the Wee1 kinase and the Cdc25 phosphatase. Wee1 phosphorylates and inhibits Cdk1, thereby restraining entry into mitosis. Cdc25 promotes entry into mitosis by removing the inhibitory phosphorylation. In addition to controlling entry into mitosis, Wee1 and Cdc25 have been proposed to integrate information from checkpoints that monitor DNA replication, cell size, and cell morphogenesis; however, the checkpoint signaling mechanisms that act upstream of Wee1 and Cdc25 are poorly understood. We have discovered a pathway that regulates Cdc25 in response to conditions that block cell growth. We will identify key players in this pathway and test the hypothesis that the pathway functions to inhibit Cdc25 activity. Thus, these experiments will define new mechanisms that regulate Cdc25 and entry into mitosis. Overexpression of Cdc25 occurs in many cancers and is thought to play an important role in genomic instability and unregulated cell proliferation. Considerable effort has therefore been focused on development of drugs that target Cdc25 activity. A better understanding of the mechanisms that regulate Cdc25 may lead to new and more effective ways of inhibiting Cdc25.
Hymenophyllum inaequale (Poir.) Desv.
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Hymenophyllum
Hymenophyllum inaequale

description: Hymenophyllum inaequale (Poir.) Desv.
MADAGASCAR: Forêt d’Andrambovato, 14 Oct. 2000, F.Rakotondrainibe 6010 (P00212518).
MAURITIUS: Macabé, 5 Oct. 2010, S.Hennequin et al. 338 (P02432402).
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 52, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Report of the Union County Mosquito Extermination Commission for 1935
Creators: name: Collins, Roi C.
Publisher: name: No Publisher Supplied
Year: 1935

description: A yearly series of reports from the Union County Mosquito Extermination Commission. The reports cover finances, inspections, drainage, oiling, and salt marsh, inland, and educational work regarding the extermination and control of mosquitoes in the different towns and districts of Union County, New Jersey.
MOESM2 of
                     Plasmodium falciparum variant erythrocyte surface antigens: a pilot study of antibody acquisition in recurrent natural infections
Creators: name: Schieck, Elise
name: E. Poole
name: Rippert, Anja
name: Peshu, Judy
name: Sasi, Philip
name: Borrmann, Steffen
name: Bull, Peter
Publisher: name: Figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: Additional file 2: Figure S1. Heat map showing heterologous recognition of each individual isolate-serum pair (and homologous recognition highlighted by bold boxes). Mean fluorescence intensity is shown for each isolate-serum pair, and is colour graded in a scale from light green (lowest values), to dark green (highest values).
Image-directed tissue analysis of breast cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: An unmet need in the assessment of treatment response in breast cancer patients undergoing neoadjuvant chemotherapy is how to more accurately depict the biologic heterogeneity of large tumors and target biopsies to the most representative or aggressive areas for pre-treatment planning and post-treatment monitoring. We propose to gain insight into the biologic heterogeneity of these large breast cancers by developing multi-voxel breast spectroscopy in the in vivo setting. In doing so, we will be able to nonivasively probe the metabolism of these large breast tumors. By coupling MR spectroscopy with MR-directed biopsy, we can directly sample different parts of the tumor based on metabolic signatures which can then be correlated with histopathology and other biologic markers. Currently, these large breast cancers are biopsied under ultrasound or palpation guidance—neither of which allows metabolic assessment. This prospective pilot project consists of the following specific aims: 1. To develop a multi-voxel spectroscopy protocol for evaluating large breast tumors. Hypothesis: Multi-voxel spectroscopy of breast tumors will be feasible in the neoadjuvant population. Multi-voxel spectroscopy will demonstrate metabolic heterogeneity as determined by variability in choline peak heights across multiple voxels, a feature that cannot be appreciated by single voxel spectroscopy. 2. To develop an MR-image guided biopsy protocol for sampling specific areas of large breast tumors during the evaluation for response to neoadjuvant chemotherapy and to evaluate the biopsy yield in comparison to reported yields of ultrasound and palpation guided techniques. Hypothesis: MR-guided biopsy will result in higher biopsy yield (fewer nondiagnostic or negative samples) than traditional guidance techniques for the baseline biopsy. 3. Secondary aim: To establish a protocol for ex vivo high resolution (11.7T) MR spectroscopy of breast tissue for quantitative measurement of metabolite concentrations. Once this protocol is developed, the goal is to be able to ultimately use high resolution ex vivo spectroscopy as a reference standard for evaluating in vivo single-voxel and multi-voxel spectroscopy. Ex vivo high resolution spectroscopy will help direct development of in vivo MR spectroscopy techniques.
Polyphlebium borbonicum (Bosch) Ebihara & Dubuisson
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Polyphlebium
Polyphlebium borbonicum

description: Polyphlebium borbonicum (Bosch) Ebihara & Dubuisson
MADAGASCAR: Massif d’Antsatrotro, Réserve Spéciale du Manongarivo, 7 Oct. 1991, F.Rakotondrainibe 1367 (P00064688); Parc National de la Montagne d’Ambre, 23 Mar. 1992, F.Rakotondrainibe 1546 (P00085774); Parc National de la Montagne d’Ambre, Lac Maudit, 29 Mar. 1992, F.Rakotondrainibe 1545 (P00085773); Parc National de la Montagne d’Ambre, 19 Jul. 1992, F.Rakotondrainibe 1791 (P00100304); Ambatomboay, RNI d’Andringitra versant Est, 31 May 1995, F.Rakotondrainibe 2767bis (P00059992); Eminiminy, 24 Oct. 1995, F.Rakotondrainibe 2913 (P00067009); Eminiminy, 2 Nov. 1995, F.Rakotondrainibe 3029 (P00067125); Réserve Spéciale d’Ivohibe, 24 Oct. 1997, F.Rakotondrainibe 4186 (P00134207); Réserve Spéciale d’Ivohibe, 28 Oct. 1997, F.Rakotondrainibe 4265 (P00134298); Befingotra, 27 Nov. 1997, F.Rakotondrainibe 2537 (P00047000).
LA RÉUNION: s.d., Richard s.n. (P01330947); Bélouve, 2 Oct. 1882, s.c. s.n. (P01330933); Bébour, 26 Mar. 1969, T.Cadet 2099 (P01330937); Cirque de Takamaka, 4 Jan. 1972, T.Cadet 3395 (P01330939); Petite Plaine des Palmistes, 11 Jan. 1973, T.Cadet 4004 (P01330941).
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 53, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Report of the Union County Mosquito Extermination Commission for 1936
Creators: name: Collins, Roi C.
Publisher: name: No Publisher Supplied
Year: 1936

description: A yearly series of reports from the Union County Mosquito Extermination Commission. The reports cover finances, inspections, drainage, oiling, and salt marsh, inland, and educational work regarding the extermination and control of mosquitoes in the different towns and districts of Union County, New Jersey.
Report of the Union County Mosquito Extermination Commission for 193&
Creators: name: Van Derwerker, Ralph J.
name: Dengler, Henry P.
name: Collins, Roi C.
Publisher: name: No Publisher Supplied
Year: 1937

description: A yearly series of reports from the Union County Mosquito Extermination Commission. The reports cover finances, inspections, drainage, oiling, and salt marsh, inland, and educational work regarding the extermination and control of mosquitoes in the different towns and districts of Union County, New Jersey.
Faint signatures in IceCube
Creators: name: Stürwald, Timo
Publisher: name: Bergische Universität Wuppertal
Year: 2024

description: Free fractionally charged particles are predicted in several extensions of the Standard Model of particle physics. They could have been produced in the early universe, in violent astrophysical processes or as a result of cosmic ray interactions in the upper atmosphere. Multiple experiments have searched for such particles with no evidence thus far. The IceCube Neutrino Observatory is a Cherenkov detector instrumenting a cubic kilometer of deep antarctic ice, suitable to search for particles carrying a fraction of the elementary charge. A previous IceCube analysis has shown a reduced trigger efficiency for particles with a charge of e/3 compared to higher analyzed charges. Due to the quadratic dependence of photon production processes on the charge, significantly less photons are emitted with a decreasing charge, resulting in faint tracks as a characteristic signature for these particles. The Faint Particle Trigger was developed to enhance the detection efficiency for faint signatures. It incorporates single isolated hits in the trigger decision, which are not used by the standard triggers that work on correlated hit pairs. The FPT was successfully deployed at South Pole and improves significantly the trigger efficiency for a broad range of charges, while increasing the event rate by a factor 1.004. This includes a relative improvement by a factor of 1.55 for a charge of e/3, compared to the standard triggers. The consecutively developed Faint Particle Filter further reduces the trigger rate of 100 Hz to approximately 8 Hz while keeping 85% of the triggered events for a charge of e/3. Implications by the Faint Particle Trigger and Filter are discussed.
Regulation of p53 by CSN5 in human cancers
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: About 50% of all human cancers carry mutations in the tumor suppressor p53, which functions in protecting normal cells from undergoing transformation in response to genotoxic stress. Stabilization of p53 is essential for the maintenance of its tumor suppressor function. Dysregulation of p53 stability/activity will lead to human tumorigenesis. p53 negative cancers generally are more resistant to current treatment strategies and alternative approaches are particularly necessary for effective treatment of these cancers. The COP9 signalosome (CSN) complex, is an evolutionally conserved protein complex present in all eukaryotes and in involved in controlling diverse cellular and developmental processes. Recent evidence has strongly linked the CSN complex and its individual subunits to cancers, and suggested the CSN as an attractive target for therapeutic intervention. The CSN plays a key role in the regulation of Cullin-containing ubiquitin E3 ligases that are central mediators of a variety of cellular functions essential during cancer progression. CSN5 (also known as Jab1), the catalytic subunit of the CSN complex, has been recognized as a key factor in regulating oncogenic and tumor suppressive functions. CSN5 is aberrantly overexpressed in various types of cancers, which has been directly linked to inactivation of the tumor suppressor p53. CSN negatively regulates p53 by interacting with p53 and facilitating its nuclear export and therefore promoting p53 degradation as well as inactivation by exclusion from its target promotors. Unfortunately, the molecular mechanism of how CSN5 affects p53 relocalization and degradation is not understood. In particular, it is not clear whether CSN5 functions independently of intact CSN complexes in this process. Recent studies in mice have demonstrated that reactivation of p53 even in advanced tumors lead to tumor regression. Therefore, a molecular understanding of CSN5-mediated p53 inactivation, and in particular identification of CSN5 binding partners required in this process, will be essential for exploiting this pathway for the development of new strategies in cancer therapy. Towards this goal, we propose a mass spectrometry-based proteomic approach to characterize the CSN5-p53 complex in cancer cells and lay the foundation for future work on potential cancer drug targets.
Hymenophyllum kuhnii C.Chr.
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Hymenophyllum
Hymenophyllum kuhnii

description: Hymenophyllum kuhnii C.Chr.
MADAGASCAR: s. loc., May 1850, L.H.Boivin s.n. (P00139614, P00139615); Parc national de la Montagne d’Ambre, Lac Maudit, 31 Mar. 1992, F.Rakotondrainibe 1544 (P00085772); Befingotra, 19 Nov. 1994, F.Rakotondrainibe 2476 (P00046942); Befingotra, 24 Nov. 1994, F.Rakotondrainibe 2509 (P00046976); Befingotra, 27 Nov. 1994, F.Rakotondrainibe 2542 (P00046641); Ambatomboay, RNI d’Andringitra, 15 May 1995, F.Rakotondrainibe 2637 (P00059817); Eminiminy, 28 Nov. 1995, F.Rakotondrainibe 3209 (P00067336); Massif d’Anjanaharibe, Forêt d’Analabe, 4 Nov. 1999, F.Rakotondrainibe 5142 (P00181123).
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 53, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Report of the Union County Mosquito Extermination Commission for 1938
Creators: name: Van Derwerker, Ralph J.
name: Dengler, Henry P.
name: Collins, Roi C.
Publisher: name: No Publisher Supplied
Year: 1938

description: A yearly series of reports from the Union County Mosquito Extermination Commission. The reports cover finances, inspections, drainage, oiling, and salt marsh, inland, and educational work regarding the extermination and control of mosquitoes in the different towns and districts of Union County, New Jersey.
Gobiidae Cuvier 1816
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Gobiidae

description: Family Gobiidae Cuvier 1816 (Fig. 3J). Gobies, Crested Gobies, Eel-Gobies, Frillfins, Mudsuckers; Gobios, Chupapiedras, Chaquetas, Bocones, Guasetas
Description: Body elongate, stout; up to 60 cm in length, but usually less than 10 cm; head short, broad; snout rounded; lateral line absent, but canals and pores on head presents; pelvic fins generally fused, forming a sucking disc; two separate dorsal fins, the first with 4–8 weak spines, the second with one weak spine and 9–18 rays (Robertson & Allen 2015, Nelson et al. 2016). Distribution: Marine, brackish, or rarely freshwater; most tropical and subtropical areas (Nelson et al. 2016). Nine genera and seventeen species in Nicaraguan freshwaters.
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 35, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Report of the Union County Mosquito Extermination Commission for 1939
Creators: name: Collins, Roi C.
Publisher: name: No Publisher Supplied
Year: 1939

description: A yearly series of reports from the Union County Mosquito Extermination Commission. The reports cover finances, inspections, drainage, oiling, and salt marsh, inland, and educational work regarding the extermination and control of mosquitoes in the different towns and districts of Union County, New Jersey.
Targeting embryonic and cancer stem cells with cell cycle inhibitors
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The inability of conventional cytotoxic chemotherapy to fully eradicate most human tumors and prevent recurrent disease is a major obstacle in treating patients with locally advanced or metastatic cancer. The ability of tumors to recur has been blamed on a subset of tumor initiating (stem) cells that are believed to be relatively resistant to conventional therapies and can reconstitute the tumor mass. Currently, no rational or effective therapy exists to directly target these tumor stem cells. The proto-oncogene MYC can activate a transcriptional program frequently identified in embryonic stem cells (ESC) and tumor cells. MYC can also reprogram normal cells to attain stem cell properties, suggesting that therapeutics directed at MYC may selectively target tumor stem cells. We have previously shown that MYC over-expressing cells are especially sensitive to the inhibition of cyclindependent kinase 1 (CDK1)/Cyclin B. The goal of this proposal is to test the hypothesis that CDK1 inhibitors can cause the selectively killing of embryonic stem cells and tumor stem cells in a MYC-dependent fashion. AIMS: I. Determine if ESCs undergo cell death following treatment with CDK1 inhibitors: A. Do CDK inhibitors induce cell death or proliferation arrest in ESCs? B. Is the response to CDK inhibitors dependent on the differentiation state of ESCs? C. Is the response of ESCs to CDK inhibitors dependent on MYC expression? D. Are other stem cell specific transcription factors required for sensitivity to CDK inhibitors? II. Determine if mammary tumor stem cells undergo cell death following treatment with CDK1 inhibitors: A. Generate mammary epithelial tumor cells enriched for tumor stem cell properties. B. Determine if mammary tumor stem cells undergo apoptosis following CDK1 inhibitor treatment. C. Determine if mammosphere formation is diminished following CDK1 inhibitor treatment.
MOESM13 of Population structure and genomic inbreeding in nine Swiss dairy cattle populations
Creators: name: Signer-Hasler, Heidi
name: Burren, Alexander
name: Neuditschko, Markus
name: Frischknecht, Mirjam
name: Garrick, Dorian
name: Stricker, Christian
name: Gredler, Birgit
name: Bapst, Beat
name: Flury, Christine
Publisher: name: Figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 13: Figure S9. Proportion of animals with this SNP within a ROH.
The molecular basis of cell cycle control by taranis, the Drosophila ortholog of human TRIP-Br oncoproteins
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: TRIP-Br proteins (Transcription Regulator Interacting with PHD and/or Bromodomains) are a recently identified group of human oncoproteins that appear to regulate cell cycle progression by modulating the activity of E2F transcription factors. TRIP-Br proteins have been proposed to serve as “integrators” of different growth signals by binding to PHD/bromodomain-containing chromatin-remodeling factors and altering E2F activity, although the mechanisms involved are not completely understood. I recently identified a Drosophila TRIP-Br ortholog, called taranis, as a regulator of cell proliferation in neuroblasts (neural stem cells). Taranis loss-of-function slows cell cycle progression and gain-of-function causes quiescent neuroblasts to enter the cell cycle. At late stages of development, taranis is expressed in non-dividing neurons, suggesting distinct roles in mitotic and non-mitotic cells. Taranis provides an ideal model for identifying the mechanisms by which TRIP-Br proteins regulate the cell cycle. The specific aims of this proposal will address two hypotheses: 1) that distinct taranis-containing protein complexes are formed in mitotic and non-mitotic cells and 2) that specific taranis-protein interactions are required for the activation of cell cycle entry. AIM 1. Identify taranis interacting proteins in mitotic and non-mitotic cells. Proteins present in a complex with taranis will be purified by immunoprecipitating myc-tagged taranis from mitotic embryonic neuroblasts and post-mitotic adult neurons. Co-immunoprecipitated proteins will be identified using two approaches; western blotting for predicted interacting proteins (e.g., known PHD/bromodomain-containing proteins), and LC/MS/MS identification of purified proteins. AIM 2. Identify taranis domains and interacting proteins that are necessary for the activation of cell cycle entry. Four mutant forms of taranis (containing deletions in evolutionarily-conserved domains) will be expressed in quiescent neuroblasts to identify domains necessary for the activation of cell cycle entry. To identify taranis interacting proteins that are required for the activation of cell cycle entry, we will combine RNAi-mediated “knockdown” of proteins identified in aim 1 with expression of taranis in quiescent neuroblasts.