cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A model of acquired resistance to the novel AR-NTD inhibitor ralaniten reveals resistance occurs via a selective metabolism pathway
Creators: name: Obst, Jonathon
Publisher: name: University of British Columbia
Year: 2020

description: Background: Inhibition of the androgen receptor (AR) is the mainstay treatment for advanced prostate cancer. While initially effective, the disease ultimately progresses to metastatic castration-resistant prostate cancer, which is lethal. Ralaniten specifically targets the AR N-terminal domain (NTD). This allows for sustained inhibition in the context of constitutively active AR-splice variants and mutations which often drive resistance to current therapies. Ralaniten acetate is the pro-drug of ralaniten, and the first AR-NTD inhibitor to enter clinical trials (NCT02606123, ESSA Pharma, Inc.). Here we generated and characterized a model of acquired ralaniten resistance to aid in the development of next generation AR-NTD inhibitors. Methods: A resistant cell line (LNCaP-RALR) was created by serially passaging parental LNCaP cells in the presence of ralaniten. Resistant cells were challenged with ralaniten and existing AR antagonists to assess growth and sensitivity of the resistant line in vitro and in vivo. LNCaP-RALR cells were subject to global microarray profiling, and findings were validated using qRT-PCR, western blot and functional assays. Results: Ralaniten displayed antitumour activity in LNCaP but not LNCaP-RALR xenografts due to its reduced ability to block AR mediated gene transcription. Interestingly, LNCaP-RALR cells retained sensitivity to antiandrogens and AR knockdown by targeted siRNA, implying growth remains driven by AR signalling. Interrogation of microarray data revealed candidate genes (UGT2B family) associated with ralaniten resistance. These genes are involved in drug metabolism (glucuronidation), and knockdown of UGT2B isoforms was sufficient to restore sensitivity to ralaniten in resistant cells. LC/MS and ion spectra data from serum samples collected from patients, revealed that ralaniten is glucuronidated in humans. EPI-045 (which is resistant to glucuronidation) significantly inhibited AR mediated transcription and proliferation in LNCaP-RALR cells - both in vitro and in vivo. Conclusions: We have generated a model of acquired ralaniten resistance, and demonstrated that selective modification of ralaniten can reduce its glucuronidation. LNCaP-RALR cells remain dependent upon AR signalling, and are sensitive to both EPI-045 and antiandrogens used clinically. This work highlights the potential for combination or sequential therapy following ralaniten resistance, and provides a model with which to test next generation AR-NTD inhibitors.
A prototypical MMPI-2 configuration of Obsessive-Compulsive Disorder
Creators: name: Femia, Giuseppe
name: Gragnani, Andrea
name: Cosentino, Teresa
name: Giacomantonio, Mauro
name: Diano, Federico
name: Bernaudo, Antonella
name: Pellegrini, Valerio
name: Mancini, Francesco
Publisher: name: Mediterranean Journal of Clinical Psychology
Year: 2020
Subjects: Differential diagnosis; HPC configuration; MMPI-2; Obsessive-compulsive disorder; Psychological assessment.

description: Background: Obsessive-Compulsive Disorder is often measured through self-report questionnaires focused on measuring symptomatology (Y-BOCS, OCI-R, and PI). The scientific literature identifies the Pt scale as a distinctive marker, but does not report data related to a specific OCD profile of the MMPI-2 test. Therefore, based on some clinical considerations and preliminary investigations, the following study aims to identify a specific MMPI-OCD configuration marked by the presence of significant indicators able to describe its psychological functioning and its key features in cognitive, emotional and affective terms. Method: In order to explore the expected relationships, 395 participants were involved (average age: 34.20 years) and evaluated through the MMPI-2 test and the Yale-Brown interview. Results: MANOVA, Multiple Linear Regression Analysis and Discriminant Function Analysis confirm that the OCD is marked by the recurrence of three elevated clinical scales (Pt, D, Sc). Hyper-prudential reasoning and some reasoning bias, typically employed by these subjects, could justify such results. Conclusions: This specific configuration could therefore support the clinician during the assessment phases and lead him to identify – as well as differentiate – his characteristics from those of other psychological disorders, thus stimulating him to deepen during the interpretation of the results.
description: Mediterranean Journal of Clinical Psychology, Vol 8, No 3 (2020)
Vulnerable narcissism and body image centrality in cosplay practice: A sequential mediation model
Creators: name: Gioia, Francesca
name: De Clemente, Martina
name: Parrello, Santa
name: Boursier, Valentina
Publisher: name: Mediterranean Journal of Clinical Psychology
Year: 2020
Subjects: Cosplay; Vulnerable narcissism; Self-objectification; Social appearance anxiety.

description: In recent years, the cosplay practice has become a ubiquitous activity, representing a pivotal way to get in touch with the so-called geek culture and its media content (such as videogames, comics, manga). Cosplaying appeared related to narcissistic fragility which in turn is strictly linked to social appearance anxiety and self-objectification experiences. However, despite the body image centrality in cosplay practice, no studies evaluated cosplayers’ narcissistic vulnerability in association with these body image-related issues. A total of 926 young adults (73.2% female; 47.3% cosplayer; mean age=25.3 years) participated in the study. Results confirmed the direct and indirect effect of narcissistic vulnerability on social appearance anxiety (via body surveillance and body shame) among both cosplayers and non-cosplayers. Overall, narcissistically vulnerable individuals, regardless of their involvement in cosplay practice, seem to experience higher body surveillance and body shame, which in turn might promote social appearance anxiety.
description: Mediterranean Journal of Clinical Psychology, Vol 8, No 3 (2020)
Rethinking Timing Residuals: Advancing PET Detectors with Explicit TOF Corrections
Creators: name: Naunheim, Stephan
name: de Paiva, Luis Lopes
name: Nadig, Vanessa
name: Kuhl, Yannick
name: Gundacker, Stefan
name: Mueller, Florian
name: Schulz, Volkmar
Publisher: name: arXiv
Year: 2025
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Machine Learning (cs.LG)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: PET is a functional imaging method that visualizes metabolic processes. TOF information can be derived from coincident detector signals and incorporated into image reconstruction to enhance the SNR. PET detectors are typically assessed by their CTR, but timing performance is degraded by various factors. Research on timing calibration seeks to mitigate these degradations and restore accurate timing information. While many calibration methods use analytical approaches, machine learning techniques have recently gained attention due to their flexibility. We developed a residual physics-based calibration approach that combines prior domain knowledge with the power of machine learning models. This approach begins with an initial analytical calibration addressing first-order skews. The remaining deviations, regarded as residual effects, are used to train machine learning models to eliminate higher-order skews. The key advantage is that the experimenter guides the learning process through the definition of timing residuals. In earlier studies, we developed models that directly predicted the expected time difference, which offered corrections only implicitly (implicit correction models). In this study, we introduce a new definition for timing residuals, enabling us to train models that directly predict correction values (explicit correction models). The explicit correction approach significantly simplifies data acquisition, improves linearity, and enhances timing performance from $371 \pm 6$ ps to $281 \pm 5$ ps for coincidences from 430 keV to 590 keV. Additionally, the new definition reduces model size, making it suitable for high-throughput applications like PET scanners. Experiments were conducted using two detector stacks composed of $4 \times 4$ LYSO:Ce,Ca crystals ($3.8\times 3.8\times 20$ mm$^{3}$) coupled to $4 \times 4$ Broadcom NUV-MT SiPMs and digitized with the TOFPET2 ASIC.
title: Immobilization and Characterization of RuCl₂(PPh₃)₃ Mesoporous Silica SBA-3
Creators: name: Grünberg, Anna
name: Gutmann, Torsten
name: Rothermel, Niels
name: Yeping, Xu
name: Breitzke, Hergen
name: Buntkowsky, Gerd
Publisher: name: De Gruyter
Year: 2021

description: The five-fold coordinated ruthenium (II) catalyst RuCl₂(PPh₃)₃ is heterogenized on the surface of amine functionalized mesoporous silica material SBA-3 and studied by BET, XRD and ³¹P CP-MAS solid-state NMR. The spectra indicate the replacement of one or two of the triphenyl-phosphine groups in the course of the grafting. To distinguish between both possibilities two-dimensional J-resolved ³¹P MAS solid-state NMR combined with quantum chemical calculations is employed. The changes of the scalar coupling pattern between the neat catalyst and the immobilized catalyst suggest the replacement of two of the PPh₃-groups by coordinative bonds to the amine-functions of the linker. DFT calculations reveal the absence of two chemically and magnetically equivalent phosphines and confirm the replacement of two PPh₃-groups. This finding is similar to the results observed for the binding of the rhodium in the Wilkinson’s catalyst, despite the different coordination of the metals (four-fold versus five-fold), the presence of two chlorine ligands and the different transition metal.
Women during the Covid-19 lockdown: more anxiety symptoms in women with children than without children and role of the resilience
Creators: name: Benassi, Erika
name: Vallone, Marianna
name: Camia, Michela
name: Scorza, Maristella
Publisher: name: Mediterranean Journal of Clinical Psychology
Year: 2020
Subjects: COVID-19; Women; Mothers; Anxiety; Resilience.

description: Backgrounds. In addition to being a public physical health emergency, Coronavirus disease 2019 (COVID-19) has been identified as a psychological health emergency of global concern. The emergency measures implemented by the Italian Government from March to June 2020 included drastic limitations to living conditions that may have impacted on women with children in particular. Nevertheless, few studies focused on them investigating psychopathological consequences of lockdown and protective factors for mental health. Aims. First aim was to examine differences on generalized anxiety symptoms between working women with children and without children; second, we investigated whether psychological resilience contributed to low emotional impact of the COVID-19 lockdown. Method. An online survey was administered to 516 working mothers and 514 working women without children. Participants responded to Generalized Anxiety Disorder Scale (GAD7) and Connor-Davidson Resilience Scale (CD-RISC 25). Results. Significant differences emerged between the two groups, with higher symptoms and percentages of generalized anxiety disorders (GADs) in the group of mothers relative to women without children. Regression analysis showed that CD-RISC 25 score, more than having/not having children, had a predictive effect on GAD7 score, concurring to reduce anxiety symptoms. Conclusions. Our findings suggest that dealing with lockdown was a particularly stressful experience for working mothers who had to balance personal life, work, and raising children without other resources. Resilience may be a protection against emotional problems and supportive interventions should be implemented in the present and in the future to promote mental health in this population.
description: Mediterranean Journal of Clinical Psychology, Vol 8, No 3 (2020)
title: Kinetics of Coupled Double Proton and Deuteron Transfer in Hydrogen-Bonded Ribbons of Crystalline Pyrazole-4-carboxylic Acid
Creators: name: Torres, Verónica
name: Lopez, Juan-Miguel
name: Langer, Uwe
name: Buntkowsky, Gerd
name: Vieth, Hans-Martin
name: Elguero, José
name: Limbach, Hans-Heinrich
Publisher: name: De Gruyter
Year: 2021

description: The proton tautomerism of pyrazole-4-carboxylic acid (PCA) has been studied by a combination of ¹⁵N CPMAS and ²H NMR spectroscopy and relaxometry. Down to 250 K, PCA forms a hydrogen bonded ribbon where adjacent carboxylic and pyrazole groups are linked by an OH···N and an O···HN hydrogen bond, forming either the tautomeric state A or B. Down to about 250 K, the tautomerism is fast on the NMR timescale and degenerate, corresponding to a phase exhibiting dynamic proton disorder. At lower temperatures, a transition to an ordered phase is observed with localized protons, assigned to an all-syn conformation adopting the sequence of tautomeric states ..ABABA.. The longitudinal ¹⁵N relaxation times T₁ of PCA-¹⁵N₂ have been measured at 9.12 MHz (2.1 T). Because of the low field, a chemical shift anisotropy mechanism could be neglected, and the data were analyzed in terms of a dipolar ¹H-¹⁵N relaxation mechanism, yielding the rate constants kHH. The rate constants kHD and kDD were obtained from the measurement and analysis of the ²H T₁ values of PCA-¹⁵N₁ -d₀.₉ and PCA-¹⁵N₁ -d₀.₁ measured at 46.03 MHz. Within the margin of error, no kinetic isotope effects could be detected, in contrast to previous results reported for the very fast tautomerism of solid benzoic acid dimers and the much slower tautomerism of solid 3,5-diphenyl-4-brompyrazole (DPBrP) dimers. The Arrhenius curves of all three systems were simulated using the Bell–Limbach tunneling model. Evidence for a major heavy atom motion for the tautomerism of PCA is obtained, associated with small angle reorientation of PCA molecules around the molecular axis. The observed proton order-disorder transition and the mechanism of the observed rate process are discussed in terms of a coupling of adjacent tautomeric states.
Unveiling stellar magnetic activity using CoRoT seismic observations
Creators: name: Mathur, Savita
name: Garcia, Rafael A.
name: Salabert, David
name: Ballot, Jerome
name: Regulo, Clara
name: Metcalfe, Travis S.
name: Baglin, Annie
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: It is well known that in the Sun, the frequencies and amplitudes of acoustic modes vary throughout the solar cycle. Indeed, while the magnetic activity goes towards its maximum, the frequencies of the modes increase and their amplitudes decrease. We have analyzed data from the CoRoT mission on a few stars that exhibit solar-like oscillations. The study of HD49933 (observed during 60 days and 137 days spanning a total of 400 days) showed a modulation of the maximum amplitude per radial mode and the frequency shifts of the modes, showing magnetic activity in this rapidly rotating star. Moreover, both properties vary in an anticorrelated way and the data allowed us to establish a lower limit for the activity-cycle period of ~120 days. Measurements in Ca H and K lines confirmed that this star is in the "active stars" category. We will also discuss the results obtained for other targets such as HD181420 and HD49835 for which we have investigated a similar behavior.
description: 6 pages, 3 figures, proceedings for SOHO 24/GONG 2010 conference, to be published in JPCS
Modulation of near-field heat transfer between two gratings
Creators: name: Biehs, Svend-Age
name: Rosa, Felipe S. S.
name: Ben-Abdallah, Philippe
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a theoretical study of near-field heat transfer between two uniaxial anisotropic planar structures. We investigate how the distance and relative orientation (with respect to their optical axes) between the objects affect the heat flux. In particular, we show that by changing the angle between the optical axes it is possible in certain cases to modulate the net heat flux up to 90% at room temperature, and discuss possible applications of such a strong effect.
Brandt extensions and primitive topological inverse semigroups
Creators: name: Berezovski, Tetyana
name: Gutik, Oleg
name: Pavlyk, Kateryna
Publisher: name: arXiv
Year: 2010
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 22A15, 54G12, 54H10, 54H12

description: In the paper we study (countably) compact and (absolutely) $H$-closed primitive topological inverse semigroups. We describe the structure of compact and countably compact primitive topological inverse semigroups and show that any countably compact primitive topological inverse semigroup embeds into a compact primitive topological inverse semigroup.
description: 11 pages
Figueiredo, P. Filipe, A Obra literária do P. Donaciano de Abreu Freire, 3 vols. de 256, 348 e 334 ps., 213x146, Estarreja 1985, 1988 e 1989
Creators: name: Arieiro, José
Publisher: name: Theologica
Year: 1989

description: Theologica, v. 24 (1989): Volumes 24, 25, 26 (1989-1991)
Novius marek Slipinski and Pang 2020, sp. nov.
Creators: name: Pang, Hong
name: Tang, Xue-Fei
name: Ślipiński, Adam
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Coccinellidae
Novius
Novius marek

description: Novius marek Ślipiński and Pang sp. nov. (Figs 30–49)  Etymology. Dedicated to our friend Prof. Marek Wanat of the Wroclaw University, Poland acknowledging his dedication to study of beetles in New Caledonia. The species name “ marek ” is derived from the first name of Marek Wanat and should be treated as a noun in apposition.  Diagnosis. This is the largest species of Novius known so far with its body length over 6.5 mm distinctly exceeding the length of the largest known Asian species reaching up to 5.1 mm. The elongate and almost completely flattened body and the characters of male genitalia will immediately distinguish this species from all larger species of the genus.  Description. Length 6.5–7.1 mm. Body elongate, 1.4–1.5 times longer than broad; dorsum weakly convex, almost flat (Figs 39–43), covered by very dense inclined yellowish pubescence, forming irregular pattern of spirals and concentric circles. Colour yellow or yellowish brown; head on vertex and pronotum with central part darker; elytra with irregular darker zigzag pattern, in some specimens hardly visible at all. Head with frontal area shallowly concave; eyes separated by about 2 widths of an eye. Antenna relatively long and loosely articulated, length 1.0–1.3 times frontal width between eyes; three terminal segments form very weak serrate club. Pronotum transverse, 2.4–2.5 times broader than long, broadest slightly before mid-length; lateral sides arcuate more strongly narrowing posteriorly than towards broadly rounded anterior angles. Elytra 1.2–1.3 times as long as broad and about 4 times as long as pronotum. Scutellum triangular, 1.1–1.2 times broader than long. All femora and tibiae slender, not much expanded. Pretarsal claw with large and pointed basal tooth in female, apically split in male. Male genitalia as in Figs 48–52. Female genitalia as in Figs 45–47.  Holotype male. New Caledonia, -21.6216 / 165.8774, Plateau de Dogny, 9.11. 2010, 960m, leg. R. Ruta (MNHN).  Paratypes all females. New Caledonia, Bourail, 10-20 December 1998, On U.V. light, leg. G.& K. Hangay (1, AM); Nov. 8.1944, Wilfred Crabb (1, USNM); – 21.6387 / 165.7697, rd to Parc des Grandes Fougeres (araucarias 1 km before gate), 7.11. 2010, 470m, at light. Leg. R.Ruta, M. Wanat (1, NHMUW); – 21.76674 / 166.00540, Mt Do, 5.11. 2008, 850m, at light. Leg. M. Wanat; DNA voucher CSR 214 (1, ANIC).
description: Published as part of Pang, Hong, Tang, Xue-Fei & Ślipiński, Adam, 2020, A New Species Of Novius Mulsant From New Caledonia (Coleoptera: Coccinellidae: Noviini), pp. 25-32 in Annales Zoologici 70 (1) on page 26, DOI: 10.3161/00034541ANZ2020.70.1.002, http://zenodo.org/record/3776657
Black swans or dragon kings? A simple test for deviations from the power law
Creators: name: Janczura, Joanna
name: Weron, Rafal
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistical Finance (q-fin.ST)
subject: Physics and Society (physics.soc-ph)
subject: Applications (stat.AP)
subject: FOS: Economics and business
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We develop a simple test for deviations from power law tails, which is based on the asymptotic properties of the empirical distribution function. We use this test to answer the question whether great natural disasters, financial crashes or electricity price spikes should be classified as dragon kings or 'only' as black swans.
The moderating effect of the dispositional resilience on the relationship between Post-traumatic Stress Disorder and the professional quality of life of the military returning from the peacekeeping operations
Creators: name: Platania, Silvia
name: Castellano, Sabrina
name: Petralia, Maria Cristina
name: Digrandi, Fabio
name: Coco, Marinella
name: Pizzo, Mariano
name: Di Nuovo, Santo
Publisher: name: Mediterranean Journal of Clinical Psychology
Year: 2020
Subjects: Dispositional resilience; Post-traumatic stress disorder; Military; Peacekeeping operation.

description: Recent studies have highlighted the increased risk of exposure to PTSD among military personnel who are faced with extreme stressor events, the stress related to the peacekeeping mission, indicates that even peacekeepers could be at risk of developing PTSD independently of war attacks or wounds. The resilience’s construct has a strong theoretical background, and in a pragmatic way has been shown to be a significant stress resistance resource in multiple groups, like those involved in military and security operations. The aim of this study was to examine the impact of resilience on the relationship between post-traumatic stress disorder (measured through the Davidson trauma scale) and professional quality of life. Our sample included 399 (138 females, 261 males) military who carried out peacekeeping operations between 2017 and 2019. In order to test the moderation hypothesis, a hierarchical regression analysis was performed, and a three-step regression model was carried out. The results that emerged in our study reveal that the moderating effect of resilience is evident in all the effects of on the professional quality of life.
description: Mediterranean Journal of Clinical Psychology, Vol 8, No 3 (2020)
title: Melting of Low Molecular Weight Compounds in Confinement Observed by ²H-Solid State NMR: Biphenyl, a Case Study
Creators: name: Sousa Amadeu, Nader de
name: Grünberg, Bob
name: Frydel, Jarek
name: Werner, Mayke
name: Limbach, Hans-Heinrich
name: Breitzke, Hergen
name: Buntkowsky, Gerd
Publisher: name: De Gruyter
Year: 2021

description: The ²H-NMR solid echo spectra of biphenyl molecules as guests in the mesopores of neat and silylated SBA-15 have been measured as a function of temperature. At low temperatures typical ²H-Pake patterns with parameters of (Qzz = 132 kHz, corresponding to Qcc = 176 kHz) and (η = 0.04) are observed. All samples exhibit a strong reduction of the melting point from the bulk value of 342.4 K to values between 222 K and 229 K, depending on both the pore diameter and the surface state and a glass like behavior of the biphenyl molecules in the melting regime. Employing the Roessler two-phase model of the modeling of glass-transitions by ²H-solid state NMR the distribution of activation energies for the rotational motions has been determined. At temperatures closely below the glass-transition temperature deviations from a static Pake pattern of an aromatic deuteron are observed, which indicate a pre-melting motion of biphenyl, which could be caused by C₂-ring flips of the phenyl rings.
Idiosyncratic ambivalence: A three-dimensional interpretative model to understand the non-adhesion of women to breast and cervical cancer screening
Creators: name: Lemmo, Daniela
name: Martino, Maria Luisa
name: Nunziante Cesaro, Adele
name: Solbakk, Jan Helge
Publisher: name: Mediterranean Journal of Clinical Psychology
Year: 2020
Subjects: Breast and cervical cancer screening; Women meaning-making; Interpretative phenomenological analysis; Health care; Risk prevention.

description: Health programs offer screening activities for the early detection of cancer in vulnerable population, but record very low participation rates. The authors have a theoretical framework to investigate the complexity of the phenomenon, in the psychodynamic and ethical dimensions, specific to women. In this study, the authors used semi-structured interviews and interpretative phenomenological analysis to explore the meaning-making processes of women who do not practice breast and cervical cancer prevention in Southern Italy neither in the public health-care system, nor in private health facilities. Three superordinate themes have emerged: taking care of oneself would be to love oneself; difficult contact with a sexual body;at the end, the fate decides. We highlight three levels in the psychism that underlie the behavior of not doing prevention: body- affects- thought. Understanding these psychic level mechanisms permits to support women's health policy, reducing costs and promoting health.
description: Mediterranean Journal of Clinical Psychology, Vol 8, No 3 (2020)
THE EFFECT OF AEROBIC DANCE EXERCISE AND BIKE EXERCISE ON MAXIMALOXYGENCONSUMPTION
Creators: name: Surachet KWANNAI
Publisher: name: The Sports Science Society of Thailand (SSST)
Year: 2020
Subjects: Aerobic dance exercise
Bike exercise
Maximal oxygen consumption

description: Journal of SportsScience and Technology, 20, 1, 51-61
Understanding the link between interoceptive deficits and binge eating symptoms among adolescents: A serial mediation analysis
Creators: name: Di Nardo, Maria
name: Marchetti, Daniela
name: Fulcheri, Mario
name: Verrocchio, Maria Cristina
Publisher: name: Mediterranean Journal of Clinical Psychology
Year: 2020
Subjects: Interoceptive deficits; Binge eating behaviors; Body uneasiness; Adolescence; Negative affectivity; Clinical psychology.

description: The aim of this study was to assess relevant psychological predictors of binge eating behaviors in a non-clinical sample of Italian male and female adolescents. To do so, 120 adolescents aged 17-21 years participated in a cross-sectional study. Cognitive-affective components of binge eating symptoms (BES) were assessed with the Binge Eating Scale. Difficulty recognizing and accurately identifying internal emotional states was assessed with the Interoceptive Deficits (ID) subscale of the Eating Disorders Inventory-3. Body uneasiness (BU) was measured using the Body Uneasiness Test. Negative affectivity (PA, NA) was assessed with the Positive and Negative Affect Schedule. Based on Pearson’s correlations results, we conducted a mediation model analysis to examine whether the ID-BES relationship was mediated by NA and BU. Examined relationships were preserved after controlling for the effect of age, gender and BMI. The current study’s findings contribute to clarify the role that BU-related NA may play on ID in the appearance of BES and provide preliminary support for the potential role of NA and BU as self-regulatory mechanisms involved in this association.
description: Mediterranean Journal of Clinical Psychology, Vol 8, No 3 (2020)
Statistics of opinion domains of the majority-vote model on a square lattice
Creators: name: Peres, Lucas R.
name: Fontanari, Jose F.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: The existence of juxtaposed regions of distinct cultures in spite of the fact that people's beliefs have a tendency to become more similar to each other's as the individuals interact repeatedly is a puzzling phenomenon in the social sciences. Here we study an extreme version of the frequency-dependent bias model of social influence in which an individual adopts the opinion shared by the majority of the members of its extended neighborhood, which includes the individual itself. This is a variant of the majority-vote model in which the individual retains its opinion in case there is a tie among the neighbors' opinions. We assume that the individuals are fixed in the sites of a square lattice of linear size $L$ and that they interact with their nearest neighbors only. Within a mean-field framework, we derive the equations of motion for the density of individuals adopting a particular opinion in the single-site and pair approximations. Although the single-site approximation predicts a single opinion domain that takes over the entire lattice, the pair approximation yields a qualitatively correct picture with the coexistence of different opinion domains and a strong dependence on the initial conditions. Extensive Monte Carlo simulations indicate the existence of a rich distribution of opinion domains or clusters, the number of which grows with $L^2$ whereas the size of the largest cluster grows with $\ln L^2$. The analysis of the sizes of the opinion domains shows that they obey a power-law distribution for not too large sizes but that they are exponentially distributed in the limit of very large clusters. In addition, similarly to other well-known social influence model -- Axelrod's model -- we found that these opinion domains are unstable to the effect of a thermal-like noise.
Application of the negative multinomial distribution to comparative Poisson clinical trials of multiple experimental treatments versus a single control
Creators: name: Chiarappa, Joseph A.
Publisher: name: No Publisher Supplied
Year: 2019

description: Clinical trials that compare one or more experimental treatments to a control treatment in which event incidence (i.e. incidence of disease or an adverse event) is rare often assume that comparative Poisson methodology is appropriate for modeling the number of events that occur in each treatment group. Clinical studies of multiple Poisson parameters may be conducted under one of two designs: (A) wait until a total number of events occur among all treatment groups before stopping the study, or (B) wait until a specified amount of time has passed before terminating the study. Exact tests under these approaches are based on the multinomial distribution.In this dissertation, we consider an alternative approach termed “Design C”, which is to wait until the control group accumulates a pre-specified number of events before stopping the study. The joint distribution of the number of events in the experimental treatment groups at the time of study stoppage, conditional on the number of events observed in the control group, follows a negative multinomial distribution (NMD). The minimum (respectively, maximum) number of events among the experimental treatment arms will be shown to be an appropriate test statistic for determining whether one or more of the experimental treatments is superior (respectively, inferior) to the control at a given one-sided overall Type I error; as such, we first determine the distribution of the order statistics of the NMD. We subsequently provide tables of trial design parameters for select values of one-sided overall Type I error and pointwise power and assuming equal allocation of study subjects to the treatment groups. These studies can be improved by applying curtailed stoppage rules; that is, follow-up of the treatment arms can be discontinued prior to the control group reaching its planned number of events once the ultimate decision is known for each arm. Curtailment has substantial practical implications as reduced follow-up implies reduced study costs and more rapid knowledge of the trial results. We provide simple algorithms to estimate the expected amount of subject follow up (presented in terms of person years) that would be needed until trial termination under both uncurtailed and curtailed stopping rules. Finally, we combine the superiority and inferiority test procedures to provide a two-sided test and briefly consider pairwise comparison of the experimental treatments to each other under the Design C framework.
Os colégios da Alta Coimbra — Episódios da vida académica — Exposição documental, vol. de 78 ps., 210x150, Coimbra 1987
Creators: name: Arieiro, José
Publisher: name: Theologica
Year: 1989

description: Theologica, v. 24 (1989): Volumes 24, 25, 26 (1989-1991)
Stellar Structure and Tests of Modified Gravity
Creators: name: Chang, Philip
name: Hui, Lam
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Theories that attempt to explain cosmic acceleration by modifying gravity typically introduces a long-range scalar force that needs to be screened on small scales. One common screening mechanism is the chameleon, where the scalar force is screened in environments with a sufficiently deep gravitational potential, but acts unimpeded in regions with a shallow gravitational potential. This leads to a variation in the overall gravitational G with environment. We show such a variation can occur within a star itself, significantly affecting its evolution and structure, provided that the host galaxy is unscreened. The effect is most pronounced for red giants, which would be smaller by a factor of tens of percent and thus hotter by 100's of K, depending on the parameters of the underlying scalar-tensor theory. Careful measurements of these stars in suitable environments (nearby dwarf galaxies not associated with groups or clusters) would provide constraints on the chameleon mechanism that are four orders of magnitude better than current large scale structure limits, and two orders of magnitude better than present solar system tests.
description: 6 pages, 4 figure, submitted to ApJ
The Role of Defensive Emotional Distancing in Loneliness of Offenders with Substance Use Disorders
Creators: name: Stojadinovic, Sanja
Publisher: name: Mediterranean Journal of Clinical Psychology
Year: 2020
Subjects: Self-differentiation; Loneliness; Substance use disorders; Defense mechanisms; Offenders.

description: Background: The abilities to effectively regulate emotions and establish meaningful interpersonal relationships are considered to be crucial for overall mental health. The current study aimed at exploring the relationship between the intrapersonal and interpersonal components of self-differentiation and the feeling of loneliness in offenders with substance use disorders. Method: Participants were 80 male offenders with opiate use disorders hospitalized at the Special Prison Hospital in Belgrade. Data were collected by using self-report Differentiation of Self Inventory and UCLA Loneliness Scale. In analyzing the data, Pearson product-moment correlation analysis and multiple regression analysis were employed. Results: As has been hypothesized, results show that loneliness is associated with a lower level of self-differentiation. The most prominent role in loneliness plays emotional cutoff. Since close relationships are interpreted as threatening, defensive emotional distancing protects from further negative, painful relationship experiences, and traumatization, but, as a consequence, leaves a person deprived of meaningful social contacts needed to fulfill the basic need for connectedness. Conclusions: Long-term use of behavioral and emotional defense mechanisms, such as distancing and denial, along with the exaggerated facade of independence and self-sufficiency, often seen in forensic clients seems to conceal chronic feelings of loneliness and longing for meaningful and emotionally fulfilling human contact. Adopting adaptive emotion regulation strategies may be an important mechanism for alleviating loneliness in offenders with substance use disorders, and probably, lead to decreasing the use of substances in an attempt to modulate emotions.
description: Mediterranean Journal of Clinical Psychology, Vol 8, No 3 (2020)
Polymethylmethacrylat-Zementbeschichtung intramedullärer Implantate
Creators: name: Rupp, Markus
name: Walter, Nike
name: Ismat, Abdullah
name: Alt, Volker
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: Antibiotika, Interne Fixatoren, Polymethylmethacrylat, Reinfektion, Staphylococcus epidermidis
subject: 610 Medizin

description: Hintergrund Die Beschichtung von intramedullären Stäben mit antibiotikahaltigem PMMA(Polymethylmethacrylat)-Knochenzement sorgt für eine hohe lokale Antibiotikakonzentration und für Stabilität bei noch nicht konsolidierten Frakturen. Allerdings kann sich bei Entfernung des Implantats Knochenzement ablösen und im Markraum von Röhrenknochen verbleiben. Fallbeschreibung Eine 56-jährige Patientin litt nach einer periprothetischen Kniegelenkinfektion an einer schmerzhaften Reinfektion mit Staphylococcus epidermidis. Es bestand eine Indikation zu einem Ausbau der Prothese. Operation Die einliegende Rotations-Scharnier-Prothese wurde nach Weichteildebridement und Synovektomie entfernt. Für eine temporäre Arthrodese wurden als intramedulläre Implantate Humerusnägel verwendet, die mit antibiotikahaltigem PMMA-Zement beschichtet waren. Um ein Ablösen des Knochenzements bei der Implantatentfernung und einen Verbleib von Zementresten im Knochen zu verhindern, wurden die Humerusnägel mit Cerclagedraht armiert. Das so beschichtete Implantat wurde dann „pressfit“ in den Markraum implantiert.
Cruz, Lígia, Documentos para o estudo da criminalidade na Beira em meados do sec. XIX, 111:1859-1871, Publicações do Arquivo da Univ. de Coimbra, vol. de 560 ps., 213x156, Coimbra 1985
Creators: name: Arieiro, José
Publisher: name: Theologica
Year: 1989

description: Theologica, v. 24 (1989): Volumes 24, 25, 26 (1989-1991)
A pilot study on alexithymia in adopted youths: prevalence and relationships with emotional-behavioral problems
Creators: name: Muzi, Stefania
name: Pace, Cecilia Serena
Publisher: name: Mediterranean Journal of Clinical Psychology
Year: 2020
Subjects: Alexithymia; Adopted child; Emotional-behavioral problems; Adolescence; Mixed-method.

description: Adopted adolescents show high rates of emotional-behavioral problems and they could also be more vulnerable to alexithymia, a risk factor for psychopathology in adolescents, that is more frequent in case of early relational trauma(s), often experienced by adoptees in pre-adoption life. However, no studies investigate alexithymia in adopted adolescents, therefore this pilot study aimed to: (a) assess the prevalence of alexithymia in adoptees in comparison with a national representative sample; (b) examine the relationships between alexithymia and emotional-behavioral problems in adoptees. Participants were 33 adoptees aged 10-19 years (54.5% boys), enrolled through social services. Measures were the self-report questionnaire Toronto Alexithymia Scale 20-item to measure participants’ alexithymia, and the Youth Self Report 11-18 years to assess emotional-behavioral problems. Main results highlighted: 1) 71% of adoptees with moderate-to-high levels of alexithymia, with adoptees as significantly more border-alexithymic (55%) than in normative peers; 2) Alexithymia and its factors Difficulty to identifying Feelings and Externally Oriented Thinking were related to more total, internalizing, externalizing and other problems (social, attentional, thought, binge-drinking, substance abuse, suicidality, etc...); 3) The difficulty identifying feelings was the unique predictor for 38% of total problems, 40% of internalizing ones, 22% of externalizing ones and 30% of other problems. In conclusion, the results suggest the clinical and scientific relevance of continuing the study of alexithymia in adopted adolescents, and future directions of research are suggested.
description: Mediterranean Journal of Clinical Psychology, Vol 8, No 3 (2020)
Essays on firm heterogeneity and entrepreneurship
Creators: name: Galindo Da Fonseca, João Alfredo
Publisher: name: University of British Columbia
Year: 2018

description: What determines firm heterogeneity? What are the consequences of this heterogeneity for the macroeconomy? Traditionally, economists have considered a representative firm as an approximation for reality. Although such a restriction can be useful to study some questions, in reality there is a great deal of heterogeneity in firm behaviour. In this work, I look at different dimensions of heterogeneity in outcomes for firms, their sources and their implications for the macroeconomy. In Chapter 1, I propose a rich general equilibrium model of entrepreneurship, where I allow both wage workers and unemployed to start firms. I show that in this framework, the lower opportunity cost of entrepreneurship for the unemployed induces the formation of lower quality firms relative to wage workers. Using a new confidential owner-employer-employee matched dataset from Canada I test these predictions by verifying that firms created by the unemployed are on average smaller and die faster. I test the mechanism behind this result, by verifying that workers are more responsive to wage changes in their decision to start a firm relative to the unemployed. Finally, I use this framework to evaluate the impact on the economy of a public policy that promotes entrepreneurship among the unemployed. In the model presented in Chapter 2, we study the choice of an individual to start a firm as a function of their outside option as an unemployed and the implications for the efficient allocation in the economy. We show that by simply adding this additional margin to an otherwise standard general equilibrium theoretical framework, wage comparative statics become richer and the efficient allocation chosen by a benevolant social planner has a new interpretation. The chapter highlights the importance of modelling the entry margin into firm ownership in determining firm heterogeneity as well as wage dynamics. In the last chapter, we turn to the study of determinants of a firm's decision of which contract to offer a worker and the implications for wage dynamics and worker retention. We verify empirically that, due to a worker retention motive, match quality affects contract choice and wage cyclicality.
Five basic lemmas for symmetric tensor products of normed spaces
Creators: name: Carando, Daniel
name: Galicer, Daniel
Publisher: name: arXiv
Year: 2011
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 46M05, 46G25, 47L22

description: We give the symmetric version of five lemmas which are essential for the theory of tensor products (and norms). These are: the approximation, extension, embedding, density and local technique lemmas. Some application of these tools to the metric theory of symmetric tensor products and to the theory of polynomials ideals are given.
description: 24 pages
Oliveira Ramos, Luís António, Catálogo dos manuscritos ultramarinos da Biblioteca Municipal do Porto, vol. de 307 ps., 250x175, Porto 1988
Creators: name: Arieiro, José
Publisher: name: Theologica
Year: 1989

description: Theologica, v. 24 (1989): Volumes 24, 25, 26 (1989-1991)
Violence and desire described by committed football-supporters in substance abuse treatment. Clinical psychodynamic findings
Creators: name: Punzi, Elisabeth H
Publisher: name: Mediterranean Journal of Clinical Psychology
Year: 2020
Subjects: Desire; Football; Masculinity; Substance abuse treatment; Violence.

description: This study concerns male clients in substance abuse treatment, who were or had been football supporters, engaged in violence. Previous research has acknowledged the connection between football and violence, substances, homosociality and masculinity. Desire and treatment needs have however not been investigated. This study contributes to this knowledge gap. It is written from a treatment viewpoint, acknowledging current psychodynamic/analytical perspectives on gender, relationships, and affects. The study is based on the author’s clinical encounters with supporters who were in psychodynamic treatment due to problems with substance use. A thematic analysis of the author’s memories of the clinical encounters was performed. Three themes were identified; Alcohol and drugs, Desire and Clinical interaction. The results show that consumption of alcohol and cocaine was intermingled with the homosocial supporter-culture and accordingly with the clients’ social life, which needs to be acknowledged in treatment. Moreover, violence was not only connected to homosocial strivings and hypermasculine behaviors, but also to desire. Same-sex desire could for example arise during fighting, which could be an alluring part of violence, while simultaneously shame-provoking. The study shows that supporters, and possibly other homosocial groups, are more diverse than sometimes presented. Accordingly, clinicians who encounter committed football supporters should be open to questions of desire, including non-normative sexual experiences, while acknowledging that the topic might be difficult for clients. Clinicians also need to understand how intertwined supporter-culture and substances are, and discuss affects and relationships with clients.
description: Mediterranean Journal of Clinical Psychology, Vol 8, No 3 (2020)
Flavor Delta(54) in SU(5) SUSY Model
Creators: name: Escobar, J. A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We design a supersymmetric SU (5) GUT model using Δ(54), a finite non-abelian subgroup of SU (3)f . Heavy right handed neutrinos are introduced which transform as three-dimensional repre-sentation of our chosen family group. The model successfully reproduces the mass hierarchical mass structures of the Standard Model, and the CKM mixing matrix. It then provides predictions for the light neutrino with a normal hierarchy and masses such that mν,1 \approx 5\times10-3 eV, mν, 2 \approx 1\times 10-2 eV, and mν,3 \approx 5 \times 10-2 eV. We also provide predictions for masses of the heavy neutrinos, and correc- tions to the tri-bimaximal matrix that fit within experimental limits, e.g. a reactor angle of -7.31o. A simple modification to our model is introduced at the end and is shown to also produce predictions that fall well within those limits.
description: 22 pages
Novius delobeli
Creators: name: Pang, Hong
name: Tang, Xue-Fei
name: Ślipiński, Adam
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Coccinellidae
Novius
Novius delobeli

description: Novius delobeli (Chazeau) Rodolia delobeli Chazeau, 1981: 57; Chazeau 1991: 152. Novius delobeli: Pang et al., 2020: 18.  Material examined. New Caledonia, 8906, 20.58S, 165.17E, 500m, Pic d’Amoa, N slopes, 31 Jan 2002, G. Monteith, Pyrethrum, tree & logs (2, QMB); 22.06S, 166.41E, 160m, Riviere Bleue Park (N): Grand Kaori, humid forest, 25.01.2004, leg. M. Wanat (1, NHMUW).
description: Published as part of Pang, Hong, Tang, Xue-Fei & Ślipiński, Adam, 2020, A New Species Of Novius Mulsant From New Caledonia (Coleoptera: Coccinellidae: Noviini), pp. 25-32 in Annales Zoologici 70 (1) on page 26, DOI: 10.3161/00034541ANZ2020.70.1.002, http://zenodo.org/record/3776657
description: {"references": ["Chazeau, J. 1981. Presence du genre Rodolia Mulsant en Nouvelle-Caledonie, et description d'une nouvelle espece: R. delobeli. Bulletin de la Societe Entomologique de France, 56: 57 - 59.", "Chazeau, J. 1991. Coleoptera Coccinellidae Noviini de Nouvelle-Caledonie. Genre Rodolia Mulsant. Memoires du Museum National d'Histoire Naturelle, Serie A Zoologie, 149: 151 - 159.", "Pang, H., X-F. Tang, R. D. Booth, N. Vandenberg, J. Forrester, J. McHugh, A. Slipinski. 2020. A revision of the Australian Coccinellidae (Coleoptera). Genus Novius Mulsant of tribe Noviini. Annales Zoologici, Warsaw, 70: 1 - 24."]}