cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Multiple metal accumulation within a manganese-specific genus
Creators: name: Fernando, Denise
name: Marshall, Alan
name: PI Forster
name: Hoebee, Susan
name: R Siegele
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Premise of the study: Plants that strongly accumulate metals may be practically beneficial, and also serve as novel resources for increasing fundamental understanding of plant biology. Australian Gossia (Myrtaceae) species are delineated by a conspicuous affinity for the heavy metal manganese (Mn), which is a micronutrient crucial to photosynthesis. This genus includes several Mn hyperaccumulators such as G. bidwillii. Unusually, in G. bidwillii foliar Mn is most highly concentrated in photosynthetic cells, an observation thus far restricted to foliar-Mn accumulation in Mn hyperaccumulators. Recent discovery that several of these Gossia species accumulate other metals in addition to Mn will enable investigation as to whether primary sequestration of metals in photosynthetic tissues is restricted to Mn. Methods: Gossia species known to accumulate nickel (Ni) or aluminum (Al) in addition to Mn were sampled in the field. Complementary proton- and electron-probe data were combined to evaluate in vivo microdistribution patterns of excessively accumulated foliar metals. Key results: It was discovered that in addition to Mn and Ni, Gossia fragrantissima accumulated foliar zinc (Zn) and cobalt (Co), with Mn, Ni, and Co most highly localized in mesophyll cells and Zn primarily located in the upper epidermis. In G. hillii, Mn and Al were highly concentrated in the palisade and epidermis, respectively. Conclusions: This investigation provides evidence that the primary disposal of excess foliar metals in photosynthetic cells is not exclusive to Mn. It offers rare intrageneric perspective on metal compartmentation, pointing to significant variation among tonoplastal metal transporters associated with detoxification. © 2013 Botanical Society of America.
Increase in the incidence of Candida parapsilosis and Candida tropicalis bloodstream infections during the coronavirus disease 2019 (COVID-19) pandemic
Creators: name: Apisarnthanarak, Anucha
name: Apisarnthanarak, Piyaporn
name: Pienthong, Thanus
name: Jantarathaneewat, Kittiya
name: Weber, David J.
name: Visuttichaikit, Suttichai
Publisher: name: Cambridge University Press (CUP)
Year: 2023

description:
To the Editor—Nosocomial candidemia is associated with substantial mortality, longer hospital stays, and higher healthcare costs. The mortality among patients with candidemia remains high and is associated with increasing in incidence of non–Candida albicans Candida spp. Previous studies have suggested that non–C. albicans candidemia has increased during the coronavirus disease 2019 (COVID-19) pandemic, probably due to the increasing use of central venous catheters, suboptimal catheter care, and concurrent corticosteroid use. Candida parapsilosis bloodstream infection (BSI) has been associated with the overuse of central venous catheters and receipt of parenteral nutrition, and risk factors for Candida tropicalis are poorly defined. Overall, the C. parapsilosis and C. tropicalis BSI incidence rates at Thammasat University Hospital increased from 0.42% to 2.24% and from 1.68% to 7.46% between 2019 and 2021, respectively, whereas the rate of C. albicans BSI remained stable at 6.70%–7.83%. We performed a case–case–control study to identify risk factors for and outcomes of C. parapsilosis and C. tropicalis BSIs at
Thammasat University Hospital (Pathum Thani, Thailand), a tertiary-care center.
Shenoute, abbot of the White Monastery near Akhmim/Panopolis (Upper Egypt), ob. c. 465.
Creators: name: Admin, CSLA
Publisher: name: University of Oxford
Year: 2016
Subjects: History

description: All evidence related to Shenoute, abbot of the White Monastery near Akhmim/Panopolis (Upper Egypt), ob. c. 465..
Effects of seed mass on seedling height and competition in European white oaks
Creators: name: U Landergott
name: F Gugerli
name: Hoebee, Susan
name: R Finkeldey
name: R Holderegger
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: The relationship between seed size and fitness in plants may depend on offspring density, especially in cases where seed size affects the outcome of competition. We investigated the relationship between seed mass, germination, intraspecific competition and seedling height in a glasshouse experiment on three European white oak species (Quercus robur, Q. petraea, Q. pubescens). Within offspring families, seed mass showed a moderate, but statistically significant effect on seedling height, i.e. seedlings from heavier seeds were slightly taller. In contrast, competition caused pronounced inequality in seedling height in pairs of competing seedlings, but in only 55.2% of all pairs the dominant competitor arose from the heavier seed. It is thus possible that a positive effect of seed mass on seedling growth can be mediated through the density of conspecific seedlings and that heterogeneity in offspring density will contribute to the maintenance of seed mass variation in oak populations. © 2012 Elsevier GmbH.
Additional file 1 of Construction of Cupriavidus necator displayed with superoxide dismutases for enhanced growth in bioelectrochemical systems
Creators: name: Chen, Ke
name: Ma, Chunling
name: Cheng, Xiaolei
name: Wang, Yuhua
name: Guo, Kun
name: Wu, Ranran
name: Zhu, Zhiguang
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Fig. S1 C. necator growth in BES at -2.5 V (vs. Ag/AgCl) without the addition of SOD or CAT. Fig. S2 Influence of free SOD on CMS growth in BES. Free SOD with the same enzyme activity as the displayed SOD was added to observe the growth of CMS in BES. Fig. S3 Stability of SOD or CAT and ability to scavenge O2.-or H2O2. (A) Stability of SOD or CAT in BES; (B) Changes in the content of O2.- in BES after the addition of SOD; (C) Change of H2O2 content in BES after the addition of CAT. Fig. S4 Influence of arabinose concentration on C. necator growth. (A) Influence of different concentrations of arabinose on the growth of C. necator; (B) Influence of arabinose (2.5 g/L) on CMS growth. Fig. S5 Comparison of growth ability and PHB production of different strains. (A) Influence on the growth of different strains. The strains grown in LB for 24 h were collected to determine OD600. (B) Determination of PHB by HPLC. The strains grown in BES for 7 days were collected and subjected to HPLC after acid hydrolysis, and the peak absorption of PHB was observed and the relevant PHB content was obtained.
Diversity of S-alleles and mate availability in 3 populations of self-incompatible wild pear (Pyrus pyraster)
Creators: name: Hoebee, Susan
name: S Angelone
name: D Csencsics
name: K Määttänen
name: R Holderegger
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Small populations of self-incompatible plants may be expected to be threatened by the limitation of compatible mating partners (i.e., S-Allee effect). However, few empirical studies have explicitly tested the hypothesis of mate limitation in small populations of self-incompatible plants. To do so, we studied wild pear (Pyrus pyraster), which possesses a gametophytic self-incompatibility system. We determined the S-genotypes in complete samplings of all adult trees from 3 populations using a PCR-RFLP approach. We identified a total of 26 different S-alleles, homologous to S-alleles of other woody Rosaceae. The functionality of S-alleles and their Mendelian inheritance were verified in artificial pollination experiments and investigations of pollen tube growth. The smallest population (N = 8) harbored 9 different S-alleles and showed a mate availability of 92.9%, whereas the 2 larger populations harbored 18 and 25 S-alleles and exhibited mate availabilities of 98.4% and 99.2%, respectively. Therefore, we conclude that even small populations of gametophytic self-incompatible plants may exhibit high diversity at the S-locus and are not immediately threatened owing to reduced mate availability. © The American Genetic Association. 2011. All rights reserved.
Determinants of mastitis in women in the CASTLE study: a cohort study
Creators: name: Meabh Cullinane
name: Amir, Lisa
name: SM Donath
name: SM Garland
name: SN Tabrizi
name: MS Payne
name: CM Bennett
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2015 Cullinane et al. Background: Mastitis is an acute, debilitating condition that occurs in approximately 20 % of breastfeeding women who experience a red, painful breast with fever. This paper describes the factors correlated with mastitis and investigates the presence of Staphylococcus aureus in women who participated in the CASTLE (Candida and Staphylococcus Transmission: Longitudinal Evaluation) study. The CASTLE study was a prospective cohort study which recruited nulliparous women in late pregnancy in two maternity hospitals in Melbourne, Australia in 2009-2011. Methods: Women completed questionnaires at recruitment and six time-points in the first eight weeks postpartum. Postpartum questionnaires asked about incidences of mastitis, nipple damage, milk supply, expressing practices and breastfeeding problems. Nasal and nipple swabs were collected from mothers and babies, as well as breast milk samples. All samples were cultured for S. aureus. "Time at risk" of mastitis was defined as days between birth and first occurrence of mastitis (for women who developed mastitis) and days between birth and the last study time-point (for women who did not develop mastitis). Risk factors for incidence of mastitis occurring during the time at risk (Incident Rate Ratios [IRR]) were investigated using a discrete version of the multivariable proportional hazards regression model. Results: Twenty percent (70/346) of participants developed mastitis. Women had an increased risk of developing mastitis if they reported nipple damage (IRR 2.17, 95 % CI 1.21, 3.91), over-supply of breast milk (IRR 2.60, 95 % CI 1.58, 4.29), nipple shield use (IRR 2.93, 95 % CI 1.72, 5.01) or expressing several times a day (IRR 1.64, 95 % CI 1.01, 2.68). The presence of S. aureus on the nipple (IRR 1.72, 95 % CI 1.04, 2.85) or in milk (IRR 1.78, 95 % CI 1.08, 2.92) also increased the risk of developing mastitis. Conclusions: Nipple damage, over-supply of breast milk, use of nipple shields and the presence of S. aureus on the nipple or in breast milk increased the mastitis risk in our prospective cohort study sample. Reducing nipple damage may help reduce maternal breast infections.
Crop acquisition of phosphorus, iron and zinc from soil in cereal/legume intercropping systems: a critical review
Creators: name: Y Xue
name: H Xia
name: P Christie
name: Z Zhang
name: L Li
name: Caixian Tang
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: (c) The Author 2016. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved.
Background Phosphorus (P), iron (Fe) and zinc (Zn) are essential elements for plant growth and development, but their availability in soil is often limited. Intercropping contributes to increased P, Fe and Zn uptake and thereby increases yield and improves grain nutritional quality and ultimately human health. A better understanding of how intercropping leads to increased plant P, Fe and Zn availability will help to improve P-fertilizer-use efficiency and agronomic Fe and Zn biofortification. Scope This review synthesizes the literature on how intercropping of legumes with cereals increases acquisition of P, Fe and Zn from soil and recapitulates what is known about root-to-shoot nutrient translocation, plant-internal nutrient remobilization and allocation to grains. Conclusions Direct interspecific facilitation in intercropping involves below-ground processes in which cereals increase Fe and Zn bioavailability while companion legumes benefit. This has been demonstrated and verified using isotopic nutrient tracing and molecular analysis. The same methodological approaches and field studies should be used to explore direct interspecific P facilitation. Both niche complementarity and interspecific facilitation contribute to increased P acquisition in intercropping. Niche complementarity may also contribute to increased Fe and Zn acquisition, an aspect poorly understood. Interspecific mobilization and uptake facilitation of sparingly soluble P, Fe and Zn from soil, however, are not the only determinants of the concentrations of P, Fe and Zn in grains. Grain yield and nutrient translocation from roots to shoots further influence the concentrations of these nutrients in grains.
Effect of interface moisture content on the interlayer bond strength
Creators: name: Gowrikanthan, Nishangani
name: Lees, Janet
Publisher: name: Apollo - University of Cambridge Repository
Year: 2025
Subjects: Interfacial bond strength
Splitting tensile test
Surface moisture content

description: Reducing carbon dioxide emissions in concrete construction is a global priority. One potential solution is functionally graded concrete, where concretes with different properties are used within a single structural element to reduce environmental impact. For functionally graded members with horizontal concrete layers, the mechanical performance of the interface zones is critical for structural behaviour. Factors such as the casting technique, concrete grade, substrate surface texture, time delay between layer deposition and moisture content all influence the interlayer properties. While studies have explored these factors, the impact of interface moisture on bond strength remains inconclusive. This research evaluates the relationship between the interface surface moisture and interlayer bond strength. Splitting tensile tests were conducted on 40 fresh-on-fresh cast layered specimens with low-slump or high-slump concrete mixes. The substrate surface moisture was controlled by drying or adding a known volume of water. In the low-slump mixes a high surface moisture content led to a 10 % reduction in bond strength, likely due to the formation of a weaker transition layer. In high-slump mixes, moisture removal resulted in 11 % reduction, potentially due to surface drying and smoothing. These findings highlight the importance of optimising interface moisture conditions to ensure adequate interlayer bonding in functionally graded concrete.
Pandemic Productivity: VR Applications in Library Settings
Creators: name: Hatch, Greg
Publisher: name: unknown
Year: 2022
Subjects: subject: Academic libraries
subject: Virtual reality

description: The University of Utah's Marriott Library introduced VR systems to patrons in 2016. Back then, set-up and use required considerable technical know-how and there were few applications of the technology beyond entertainment and passive education. VR systems today are intuitive, relatively inexpensive, and can be applied to learning environments, workplace productivity, and research opportunities. During the first year of the COVID-19 pandemic, the entire Creativity & Innovation Services department was enlisted to put those assertions to the test. Connecting with one another on Oculus Quest headsets from our individual homes, seven library faculty and staff experimented with a variety of VR applications to attend staff meetings, host a team retreat, engage in team building activities, and collaboratively design a new workspace that was built in the Marriott Library during the 2021-2022 academic year. This poster session will document the challenges, learning curves, and successes of these experiments. It will also provide best practices for librarians who would like to adopt this visually immersive tool into their own work environment. Along with the poster, I will have several working VR headsets available for attendees to view apps and virtual spaces used in these experiments.
sj-pdf-1-lrt-10.1177_1477153520958463 - Supplemental material for Direct measurement of the contribution of street lighting to satellite observations of nighttime light emissions from urban areas
Creators: name: CCM Kyba
name: A Ruby
name: HU Kuechly
name: B Kinzey
name: N Miller
name: J Sanders
name: J Barentine
name: R Kleinodt
name: B Espey
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, sj-pdf-1-lrt-10.1177_1477153520958463 for Direct measurement of the contribution of street lighting to satellite observations of nighttime light emissions from urban areas by CCM Kyba, A Ruby, HU Kuechly, B Kinzey, N Miller, J Sanders, J Barentine, R Kleinodt and B Espey in Lighting Research & Technology
Additional file 2 of Changes in trauma-related emergency medical services during the COVID-19 lockdown in the Western Cape, South Africa
Creators: name: Pettke, Aleksandra
name: Stassen, Willem
name: Laflamme, Lucie
name: Wallis, Lee Alan
name: Hasselberg, Marie
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Mental Health
subject: Computational Biology

description: Additional file 2. Supplementary Tables 1—3.
Celebrating an herbarium milestone: CONN's 200,000th databased specimen
Creators: name: Taylor, Sarah
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference poster on Celebrating an herbarium milestone: CONN's 200,000th databased specimen by Collections Manager Sarah Taylor of Collections Manager G.S. Torrey Herbarium, University Of Connecticut (CONN) Storrs United States for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Dense 3D Neural Map Reconstruction Only Using a Low-cost LiDAR
Creators: name: Wang, Guangming
name: Mathew, Alwyn
name: Wang, Mudan
name: Wen, Ya
name: Alavi, Hamidreza
name: Chen, Weiwei
name: Brilakis, Ioannis
Publisher: name: Apollo - University of Cambridge Repository
Year: 2025

description: Scanning plays a vital role in civil engineering, automation construction, and remote sensing, which is the basis for high-level tasks like Building Information Modeling (BIM) and construction quality control. However, static scanning requires a significant amount of manual labour and time. Mobile scanning has reduced the time and post-processing work compared to traditional static scanning. However, the point cloud density in mobile scanning is often lower than that of static scanning. To address this challenge, we propose a novel approach that only relies on a cheaper LiDAR to enhance scanning resolution. Our approach employs explicit LiDAR odometry for odometry estimation and AI-based neural 3D dense mapping. The approach combines the high-precision registration of current explicit LiDAR odometry with the strategy of jointly optimising global temporal information through neural map representations. As a result, it achieves high accuracy in localisation and increased density in mapping. These case studies on building scenes demonstrate that this method significantly improves the point cloud density of original scans.
Determination and correlation of herbicide residues in water and sediments from the streams flowing into the Caledon River in the eastern Free State using the bubble-in-drop single drop micro-extraction method
Creators: name: George, Mosotho Joseph
Publisher: name: European Chemical Bulletin
Year: 2014

description: Environmental monitoring of metolachlor and atrazine herbicides in water samples has been reported recently with the use of the recently reported “bubble-in-drop single drop micro-extraction” (BID-SDME) method. This study reports the application of this method coupled with the hot-water extraction for the analysis of these herbicides residues from the water and sediment samples obtained in the streams running into the Caledon River in the eastern Free State – South Africa using the hot-water extraction (for the sediments) coupled to BID-SDME. The method was validated for several figures of merit before application to the real samples: it showed sufficient robustness (%RSD < 7% repeatability and reproducibility); sufficient linearity with 0.9991 > R2 > 0.9978, accuracy of 98% using 5 ng mL-1 atraton CRM in water. The results demonstrated that both these herbicides are widely used in the farms as all the streams had detectable levels of at least one herbicide with concentrations ranging from 5 ng mL-1 to about 30 ng mL-1 for water samples and 1 ng mL-1 to 35 ng mL -1 in the sediment samples with some positive correlation between the abundance in the two media (R2 = 0.8267 for atrazine and 0.9012 for metolachlor). The analyte recoveries from the samples relative to HPLC grade water solutions were higher than 90% demonstrating sufficient recovery. Some related compounds (simazine, terbutylazine and acetochlor) were also detected in some of these samples, although not quantified for lack of appropriate standards.
description: European Chemical Bulletin, Vol 3, No 10-12 (2014): European Chemical Bulletin
A randomised controlled trial of supplemental oxygen versus medical air during exercise training in people with chronic obstructive pulmonary disease: supplemental oxygen in pulmonary rehabilitation trial (SuppORT) (Protocol)
Creators: name: Alison, JA
name: McKeough, ZJ
name: Jenkins, SC
name: Holland, Anne
name: Hill, K
name: Morris, NR
name: Leung, RWM
name: Williamson, KA
name: Spencer, LM
name: Hill, CJ
name: Lee, AL
name: Seale, H
name: Cecins, N
name: McDonald, CF
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3201
subject: Cardiovascular medicine and haematology

description: Background: Oxygen desaturation during exercise is common in people with chronic obstructive pulmonary disease (COPD). The aim of the study is to determine, in people with COPD who desaturate during exercise, whether supplemental oxygen during an eight-week exercise training program is more effective than medical air (sham intervention) in improving exercise capacity and health-related quality of life both at the completion of training and at six-month follow up. Methods/Design: This is a multi-centre randomised controlled trial with concealed allocation, blinding of participants, exercise trainers and assessors, and intention-to-treat analysis. 110 people with chronic obstructive pulmonary disease who demonstrate oxygen desaturation lower than 90 % during the six-minute walk test will be recruited from pulmonary rehabilitation programs in seven teaching hospitals in Australia. People with chronic obstructive pulmonary disease on long term oxygen therapy will be excluded. After confirmation of eligibility and baseline assessment, participants will be randomised to receive either supplemental oxygen or medical air during an eight-week supervised treadmill and cycle exercise training program, three times per week for eight weeks, in hospital outpatient settings. Primary outcome measures will be endurance walking capacity assessed by the endurance shuttle walk test and health-related quality of life assessed by the Chronic Respiratory Disease Questionnaire. Secondary outcomes will include peak walking capacity measured by the incremental shuttle walk test, dyspnoea via the Dyspnoea-12 questionnaire and physical activity levels measured over seven days using an activity monitor. All outcomes will be measured at baseline, completion of training and at six-month follow up. Discussion: Exercise training is an essential component of pulmonary rehabilitation for people with COPD. This study will determine whether supplemental oxygen during exercise training is more effective than medical air in improving exercise capacity and health-related quality of life in people with COPD who desaturate during exercise. Trial registration: Australian New Zealand Clinical Trials Registry ACTRN12612000395831 , 5th Jan,2012
High entropy alloys and Corrosion resistance –A Bird’s eye view
Creators: name: John Mary, S.
name: Rajan, Nagalakshmi
name: Rajendran, Susai
name: Epshipha, R.
Publisher: name: European Chemical Bulletin
Year: 2015

description: Abstract

            The introduction of high entropy alloys (HEA) concept broke up the traditional rule that the main elements take up more than 50% atomic content. HEA means that alloys are composed of multi elements and each takes up a relatively high but less than 35% of atomic content. The properties of this innovative alloy  are decided by the combined action of multi elements. HEA tends to form simple crystallization phase. By controlling the composition , it is possible to achieve high-hardness and high-abrasion performance at high temperature, Microstructure and properties of several HEAs prepared by various methods such as  powder metallurgy laser cladding etc, are discussed. The corrosion resistance of HEAs are also discussed .

KEYWORDS: High entropy alloys, corrosion resistance, micro structure, properties, applications
description: European Chemical Bulletin, Vol 3, No 10-12 (2014): European Chemical Bulletin
Isolation, purification and characterisation of an antimicrobial compound produced by Burkholderia sp. from Batu Timbang, Sabah, Malaysia
Creators: name: Chung, Aurelie Sarah Mok Tsze
Publisher: name: Monash University
Year: 2025
Subjects: classificationCode: 310701
subject: Bacteriology
classificationCode: 310704
subject: Microbial genetics
classificationCode: 340502
subject: Natural products and bioactive compounds

description: The effective use of antibiotics is being compromised by the emergence of antimicrobial resistance (AMR). The search for new antibiotics remains thus an indispensable strategy to overcome AMR. A novel Burkholderia species was isolated from a pristine forest (Imbak Canyon Conservation Area) in Batu Timbang, Sabah (Malaysia). This strain demonstrated promising antibacterial activity against many bacterial pathogens, particularly against MDR gram-negative Acinetobacter baumannii. This novel species possesses a high number of biosynthetic gene clusters including a supergene cluster. The antibacterial compound was purified and identified through various spectroscopic methods, and partially characterised. This novel isolated Burkholderia sp. strain seems to be a promising resource for therapeutic applications in the combat against AMR.
A randomised controlled trial of a Mediterranean Dietary Intervention for Adults with Non Alcoholic Fatty Liver Disease (MEDINA): study protocol
Creators: name: George, Elena
name: Roberts, SK
name: Nicoll, AJ
name: Ryan, MC
name: Itsiopoulos, Catherine
name: Salim, Agus
name: Tierney, Audrey
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 3210
subject: Nutrition and dietetics

description: Background: Non-alcoholic fatty liver disease, the most prevalent liver disease in developed countries, remains difficult to manage with no proven safe and effective pharmacotherapy available. While weight reduction is the most commonly practiced treatment strategy, this is difficult to both achieve and/or maintain in the majority. Furthermore evidence-based dietary recommendations to guide the nutritional management of these patients are lacking. Using a randomised controlled trial design, this study compares the effectiveness of the Mediterranean diet to a standard low fat diet in terms of differences in insulin sensitivity, hepatic steatosis and metabolic outcomes in participants with non-alcoholic fatty liver disease. Methods: Ninety four eligible patients who have non-alcoholic fatty liver disease and who are insulin resistant, will be randomised into either a Mediterranean or low fat diet group for a 3 month intervention period. Insulin sensitivity will be measured on peripheral blood using Homeostatic Model Assessment and liver fat content quantified using Magnetic Resonance Spectroscopy. Both arms will consist of three face to face and three telephone call follow up consultations delivered by an Accredited Practicing Dietitian. The intervention arm focuses on recommendations from the traditional Mediterranean diet which have been tailored for use in the Australian population The standard arm uses the Australian Guide to Healthy Eating and the Australian National Heart Foundation dietary guidelines. Study recruitment will take place at four major metropolitan hospitals in Melbourne, Australia. Data collection will occur at all face to face reviews including baseline, 6, and 12 weeks. A follow up assessment to measure sustainability will take place at 6 and 12 months. The primary end point is improved insulin sensitivity scores at the 12 week time point. Discussion: This trial aims to demonstrate in a large cohort of participants with NALFD that a Mediterranean diet independent of weight loss can result in significant benefits in liver fat and insulin sensitivity and that these changes are sustained at 12 months. These metabolic changes would potentially lead to reductions in the risk of chronic liver disease, heart disease, type 2 diabetes and liver cancer. Trial registration: Australia and New Zealand Clinical Trials Register ACTRN: ACTRN12615001010583.
SENSING ASCORBIC ACID WITH DNA/PRUSSIAN BLUE CARBON PASTE ELECTRODE
Creators: name: Parepalli, Yugandhar
name: Sankar, T. Ravi
name: Rao, P.T.S.R.K. Prasada
name: Nair, Manju Shree
name: Pamanji, Sudhakar Reddy
name: Chavali, Murthy
Publisher: name: European Chemical Bulletin
Year: 2015

description: A simple sensor for the detection of ascorbic acid (AA) was developed. The electrochemical behaviors were studied after successfully constructing through DNA electro-deposition on carbon paste electrode using Prussian blue (PB). The electrodes were characterized by Raman spectroscopy that confirmed electro-deposition of PB, functioning as a redox mediator. The detection method was based on DNA damage induced by hydroxyl radical generated by Fenton reaction in which ascorbic acid effectively scavenges the hydroxyl radical. The amount of DNA damage is proportional to the amount of ascorbic acid concentration which was analyzed by cyclic voltametry (CV). Obtained results show that DNA-based biosensor can be utilized for estimating ascorbic acid in vitamin-c tablets. The detection range of this biosensor was in the range of 1.14 µM to 12.54 µM. Interference effects and stability of the biosensor were also investigated, results show that the biosensor has high sensitivity and selectivity towards ascorbic acid concentrations.
description: European Chemical Bulletin, Vol 3, No 10-12 (2014): European Chemical Bulletin
For Us, By Us: Critically Cataloging Black Arts Material
Creators: name: Caldwell, Nicholas
Publisher: name: unknown
Year: 2022

description: The Black Arts Movement (BAM) was an African-American lead artistic and aesthetic movement that was highly active during the 1960s and 1970s in Chicago. Often called the cultural arm to the Black Power Movement, the goal of BAM was to provide positive and empowering depictions of the Black community, produced by and for Black people. The innovative aesthetics and production methods of BAM have heavily influenced African-American cultural production from then to present. However, these works are often difficult to find, access, and research in libraries and other cultural institutions. This is in part because BAM works disrupt our traditional standards for descriptive cataloging. Works produced by BAM artists were often created collaboratively and involved multiple media, which can complicate our traditional ideas of who counts as contributors to a work and the boundaries we draw between media categories. Additionally, there are paratextual elements of these works that are essential to their discoverability that would not typically be catalogued in more traditionally produced material. This lightning talk focuses on how critical, ethical, and anti-racist cataloging come into play when describing materials created during the Black Arts Movement of the 1960-70s. The talk will provide specific examples of how enhancing catalog records can make these materials more discoverable to researchers, focusing on works published by Black-owned presses in the United States.
Human Endometrial Exosomes Contain Hormone-Specific Cargo Modulating Trophoblast Adhesive Capacity: Insights into Endometrial-Embryo Interactions
Creators: name: Greening, David
name: Nguyen, HPT
name: Elgass, K
name: Simpson, Richard
name: Salamonsen, LA
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Embryo implantation into receptive endometrium requires synergistic endometrial-blastocyst interactions within the uterine cavity and is essential for establishing pregnancy. We demonstrate that exosomes (40-150 nm nanovesicles) released from endometrial epithelial cells are an important component of these interactions. We defined the proteome of purified endometrial epithelial-derived exosomes (Exos) influenced by menstrual cycle hormones estrogen (E; proliferative phase) and estrogen plus progesterone (EP; receptive phase) and examined their potential to modify trophoblast function. E-/EP-Exos were uniquely enriched with 254 and 126 proteins, respectively, with 35% newly identified proteins not previously reported in exosome databases. Importantly, EP-Exos protein cargo was related to fundamental changes in implantation: Adhesion, migration, invasion, and extracellular matrix remodeling. These findings from hormonally treated ECC1 endometrial cancer cells were validated in human primary uterine epithelial cell-derived exosomes. Functionally, exosomes were internalized by human trophoblast cells and enhanced their adhesive capacity, a response mediated partially through active focal adhesion kinase (FAK) signaling. Thus, exosomes contribute to the endometrialembryo interactions within the human uterine microenvironment essential for successful implantation.
SI_NO_links – Supplemental material for Decision-based territorial life cycle assessment for the management of cement concrete demolition waste
Creators: name: Mousavi, Marjan
name: Ventura, Anne
name: Antheaume, Nicolas
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, SI_NO_links for Decision-based territorial life cycle assessment for the management of cement concrete demolition waste by Marjan Mousavi, Anne Ventura and Nicolas Antheaume in Waste Management & Research
Additional file 1 of Good practice recommendations on implementation evaluation for policies targeting diet, physical activity, and sedentary behaviour
Creators: name: Wendt, Janine
name: Scheller, Daniel A.
name: Banik, Anna
name: Luszczynska, Aleksandra
name: Forberger, Sarah
name: Zeeb, Hajo
name: Scheidmeir, Marie
name: Kubiak, Thomas
name: Lien, Nanna
name: Meshkovska, Biljana
name: Lobczowska, Karolina
name: Romaniuk, Piotr
name: Neumann-Podczaska, Agnieszka
name: Wieczorowska-Tobis, Katarzyna
name: Steinacker, Jürgen M.
name: Mueller-Stierlin, Annabel S.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 1.
S3_Table_2Theory_based_methods_practical_applications_of_the_training – Supplemental material for Using intervention mapping in motivational interviewing training to improve ART uptake in Gauteng, South Africa
Creators: name: Idah Mokhele
name: Tembeka Sineke
name: Vujovic, Marnie
name: Fox, Matthew P
name: Ruiter, Robert AC
name: Onoya, Dorina
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, S3_Table_2Theory_based_methods_practical_applications_of_the_training for Using intervention mapping in motivational interviewing training to improve ART uptake in Gauteng, South Africa by Idah Mokhele, Tembeka Sineke, Marnie Vujovic, Matthew P Fox, Robert AC Ruiter and Dorina Onoya in Journal of Health Psychology
A pilot study on biomarkers for tendinopathy: lower levels of serum TNF-α and other cytokines in females but not males with Achilles tendinopathy.
Creators: name: Gaida, James E
name: Alfredson, Hakan
name: Forsgren, Sture
name: Cook, Jillianne
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4206
subject: Public health
classificationCode: 4207
subject: Sports science and exercise

description: Background: Achilles tendinopathy is a painful musculoskeletal condition that is common among athletes, and which limits training capacity and competitive performance. The lack of biomarkers for tendinopathy limits research into risk factors and also the evaluation of new treatments. Cytokines and growth factors involved in regulating the response of tendon cells to mechanical load have potential as biomarkers for tendinopathy. Methods: This case–control study compared serum concentration of cytokines and growth factors (TNF-α, IL-1β, bFGF, PDFG-BB, IFN-γ, VEGF) between individuals with chronic Achilles tendinopathy and controls. These were measured in fasting serum from 22 individuals with chronic Achilles tendinopathy and 10 healthy controls. Results were analysed in relation to gender and physical activity pattern. Results: TNF-α concentration was lower in the entire tendinopathy group compared with the entire control group; none of the other cytokines were significantly different. TNF-α levels were nevertheless highly correlated with the other cytokines measured, in most of the subgroups. Analysed by gender, TNF-α and PDGF-BB concentrations were lower in the female tendinopathy group but not the male tendinopathy group. A trend was seen for lower IL-1β in the female tendinopathy group. Physical activity was correlated with TNF-α, PDGF-BB and IL-1β to varying extents for control subgroups, but not for the female tendinopathy group. No correlations were seen with BMI or duration of symptoms. Conclusions: This pilot study indicates a lower level of TNF-α and PDGF-BB, and to some extent IL-1β among females, but not males, in the chronic phase of Achilles tendinopathy. It is suggested that future studies on tendinopathy biomarkers analyse male and female data separately. The lack of correlation between cytokine level and physical activity in the female tendinopathy group warrants further study.
Changing Natures. Developing a Shared Participatory, Digital Collection of the Anthropocene
Creators: name: Heyne, Elisabeth
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Changing Natures. Developing a Shared Participatory, Digital Collection of the Anthropocene by Elisabeth Heyne of Museum Für Naturkunde Berlin Berlin Germany for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
title: Treatment with inhaled medical gases to improve myocardial and neurological outcome after cardiac arrest
Creators: name: De Giorgio, Daria
Publisher: name: The Open University
Year: 2025

description: Introduction Heart and brain protection exerted by argon (Ar) ventilation after cardiac arrest and cardiopulmonary resuscitation (CA/CPR) was demonstrated in preclinical animal models. The aim of this thesis is to provide new pathophysiological insights of Ar treatment after CA/CPR. This thesis will:

1. Investigate mechanisms of heart and brain protection induced by Ar after CA/CPR, focusing on the alterations in mitochondrial integrity and function.

2. Investigate the association of inhaled Ar treatment with a novel protective intervention, i.e. hydrogen (H2) on brain and myocardial injury.


Methods For the first aim, a reliable experimental model of CA/CPR in rats was used. For the second aim, a preclinical model of CA/CPR in pigs was employed.

Neurological and myocardial function together with histological damage to the heart and brain were assessed using scales, imaging (echocardiography and magnetic resonance) and immunohistochemistry approaches. Tissue protein expression levels of mitochondrial integrity mediators were assessed by Western Blot analyses. The identification of mitochondrial ultrastructure parameters was investigated by transmission electron microscopy in rodents.


Results CA/CPR in rats induced neurological and cardiac impairment together with alterations in mitochondrial morphology and integrity, making this model suitable to monitor the efficacy of inhaled Ar intervention. In this model, ventilation with Ar conferred cardioprotective effects by mitochondrial protection by the activation of mitochondrial biogenesis and mitophagy processes.

In pigs, the inhalatory mixture of 68% Ar +2% H2 in oxygen reduced both neuronal degeneration and neuroinflammation after CA.


Conclusion Alterations in mitochondrial integrity and function are strongly implicated in myocardial and brain injury after CA/CPR; myocardial and neurological protection exerted by Ar treatment seems to be related to this mitochondrial protection. The combined use of Ar and H2 may offer a promising, cost-effective intervention to reduce post-CA brain injury by leveraging the distinct protective mechanisms each gas provides concurrently.
Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancers
Creators: name: Burvenich, Ingrid
name: Lee, Fook-Thean
name: O'Keefe, GJ
name: Makris, D
name: Cao, D
name: Gong, Sylvia
name: Rigopoulos, Angela
name: Allan, LC
name: Brechbiel, MW
name: Liu, Z
name: Ramsland, PA
name: Scott, Andrew
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 3211
subject: Oncology and carcinogenesis

description: Background: The aim of the study was to explore Fc mutations of a humanised anti-Lewis-Y antibody (IgG1) hu3S193 as a strategy to improve therapeutic ratios for therapeutic payload delivery. Methods: Four hu3S193 variants (I253A, H310A, H435A and I253A/H310A) were generated via site-directed mutagenesis and radiolabelled with diagnostic isotopes iodine-125 or indium-111. Biodistribution studies in Lewis-Y-positive tumour-bearing mice were used to calculate the dose in tumours and organs for therapeutic isotopes (iodine-131, yttrium-90 and lutetium-177). Results: 111In-labelled I253A and H435A showed similar slow kinetics (t1/2β, 63.2 and 62.2 h, respectively) and a maximum tumour uptake of 33.11 ± 4.05 and 33.69 ± 3.77 percentage injected dose per gramme (%ID/g), respectively. 111In-labelled I253A/H310A cleared fastest (t1/2β, 9.1 h) with the lowest maximum tumour uptake (23.72 ± 0.85 %ID/g). The highest increase in tumour-to-blood area under the curve (AUC) ratio was observed with the metal-labelled mutants (90Y and 177Lu). 177Lu-CHX-A" DTPA-hu3S193 I253A/H310A (6:1) showed the highest tumour-to-blood AUC ratio compared to wild type (3:1) and other variants and doubling of calculated dose to tumour based on red marrow dose constraints. Conclusions: These results suggest that hu3S193 Fc can be engineered with improved therapeutic ratios for 90Y- and 177Lu-based therapy, with the best candidate being hu3S193 I253A/H310A for 177Lu-based therapy.
Table_Supp – Supplemental material for Physicians’ predictions of long-term survival and functional outcomes do not influence the decision to admit patients with advanced disease to intensive care: A prospective study
Creators: name: Escher, Monica
name: Nendaz, Mathieu
name: Scherer, Fabienne
name: Cullati, Stéphane
name: Perneger, Thomas
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, Table_Supp for Physicians’ predictions of long-term survival and functional outcomes do not influence the decision to admit patients with advanced disease to intensive care: A prospective study by Monica Escher, Mathieu Nendaz, Fabienne Scherer, Stéphane Cullati and Thomas Perneger in Palliative Medicine
Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancers
Creators: name: Burvenich, IJG
name: Lee, Fook-Thean
name: O'Keefe, GJ
name: Makris, D
name: Cao, D
name: Gong, Sylvia
name: Rigopoulos, Angela
name: Allan, LC
name: Brechbiel, MW
name: Liu, Z
name: Ramsland, PA
name: Scott, Andrew
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Background: The aim of the study was to explore Fc mutations of a humanised anti-Lewis-Y antibody (IgG1) hu3S193 as a strategy to improve therapeutic ratios for therapeutic payload delivery. Methods: Four hu3S193 variants (I253A, H310A, H435A and I253A/H310A) were generated via site-directed mutagenesis and radiolabelled with diagnostic isotopes iodine-125 or indium-111. Biodistribution studies in Lewis-Y-positive tumour-bearing mice were used to calculate the dose in tumours and organs for therapeutic isotopes (iodine-131, yttrium-90 and lutetium-177). Results: 111In-labelled I253A and H435A showed similar slow kinetics (t1/2β, 63.2 and 62.2 h, respectively) and a maximum tumour uptake of 33.11 ± 4.05 and 33.69 ± 3.77 percentage injected dose per gramme (%ID/g), respectively. 111In-labelled I253A/H310A cleared fastest (t1/2β, 9.1 h) with the lowest maximum tumour uptake (23.72 ± 0.85 %ID/g). The highest increase in tumour-to-blood area under the curve (AUC) ratio was observed with the metal-labelled mutants (90Y and 177Lu). 177Lu-CHX-A" DTPA-hu3S193 I253A/H310A (6:1) showed the highest tumour-to-blood AUC ratio compared to wild type (3:1) and other variants and doubling of calculated dose to tumour based on red marrow dose constraints. Conclusions: These results suggest that hu3S193 Fc can be engineered with improved therapeutic ratios for 90Y- and 177Lu-based therapy, with the best candidate being hu3S193 I253A/H310A for 177Lu-based therapy.
sj-pdf-1-std-10.1177_0956462420945928 - Supplemental material for Syphilis in heterosexual women: case characteristics and risk factors for recent syphilis infection in Tokyo, Japan, 2017–2018
Creators: name: Nishiki, Shingo
name: Arima, Yuzo
name: Yamagishi, Takuya
name: Hamada, Takashi
name: Takuri Takahashi
name: Tomimasa Sunagawa
name: Tamano Matsui
name: Oishi, Kazunori
name: Ohnishi, Makoto
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-std-10.1177_0956462420945928 for Syphilis in heterosexual women: case characteristics and risk factors for recent syphilis infection in Tokyo, Japan, 2017–2018 by Shingo Nishiki, Yuzo Arima, Takuya Yamagishi, Takashi Hamada, Takuri Takahashi, Tomimasa Sunagawa, Tamano Matsui, Kazunori Oishi and Makoto Ohnishi in International Journal of STD & AIDS