cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The galaxy-galaxy strong lensing cross-sections of simulated LCDM galaxy clusters
Creators: name: Robertson, Andrew
Publisher: name: arXiv
Year: 2021
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We investigate a recent claim that observed galaxy clusters produce an order of magnitude more galaxy-galaxy strong lensing (GGSL) than simulated clusters in a LCDM cosmology. We take galaxy clusters from the C-EAGLE hydrodynamical simulations and calculate the expected amount of GGSL for sources placed behind the clusters at different redshifts. The probability of a source lensed by one of the most massive C-EAGLE clusters being multiply imaged by an individual cluster member is in good agreement with that inferred for observed clusters. We show that numerically converged results for the GGSL probability require higher resolution simulations than had been used previously. On top of this, different galaxy formation models predict cluster substructures with different central densities, such that the GGSL probabilities in LCDM cannot yet be robustly predicted. Overall, we find that galaxy-galaxy strong lensing within clusters is not currently in tension with the LCDM cosmological model.
description: 5 pages, 3 figures, submitted to MNRAS Letters, updated reference to Bahe 2021 from v1
Additional file 2 of Blood pressure and risk of cancer: a Mendelian randomization study
Creators: name: Chan, Io Ieong
name: Kwok, Man Ki
name: Schooling, C. Mary
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: Additional file 2: Supplementary Figure S2. Mendelian randomization estimates of ever-smoking on total cancer.
Unparticle Self-Interactions and Their Collider Implications
Creators: name: Feng, Jonathan L.
name: Rajaraman, Arvind
name: Tu, Huitzu
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In unparticle physics, operators of the conformal sector have self-interactions, and these are unsuppressed for strong coupling. The 3-point interactions are completely determined by conformal symmetry, up to a constant. We do not know of any theoretical upper bounds on this constant. Imposing current experimental constraints, we find that these interactions mediate spectacular collider signals, such as $pp -> U -> UU -> γγγγ$, $γγZZ$, $ZZZZ$, $γγl^+ l^-$, $ZZ l^+ l^-$, and $4l$, with cross sections of picobarns or larger at the Large Hadron Collider. Self-interactions may therefore provide the leading discovery prospects for unparticle physics.
description: 12 pages, 5 figures; v2: published version
Teaching What, Where, Whom, and for What Purpose? – This Volume Leaves Readers Puzzled, at Best
Creators: name: Christ, Birte
Publisher: name: KULT_online
Year: 2012

description: Teaching Cultural Studies aims to provide ideas and models for course designs and learning techniques, to suggest suitable secondary and primary sources to be used in teaching, and to reflect on the methodological thinking that should feed into cultural studies teaching. Unfortunately, the volume remains unfocused: it is unclear what 'cultural studies' is understood to be and whether the volume is directed toward instructors or students; issues specific to teaching cultural studies in "German tertiary education," (p. 7) which the volume claims to address, are not in fact raised. Due to this lack of positioning, teaching goals remain undefined. It is similarly unfortunate that the individual essays focus on 'matter,' that is on content, much more than on 'methods,’ 'models,’ and a reflection on those methods. These shortcomings arise from the conception of the volume rather than from the individual contributions: some articles provide great teaching inspiration as well as reflections on specific challenges.
description: KULT_online, Nr. 33 (2012): KULT_online 33 (2012)
First Co-spatial Comparison of Stellar, Neutral-, and Ionized-gas Metallicities in a metal-rich galaxy: M83
Creators: name: Hernandez, Svea
name: Aloisi, Alessandra
name: James, Bethan L.
name: Kumari, Nimisha
name: Berg, Danielle
name: Adamo, Angela
name: Blair, William P.
name: Faucher-Giguère, Claude-André
name: Fox, Andrew J.
name: Gurvich, Alexander B.
name: Hafen, Zachary
name: Heckman, Timothy M.
name: Lebouteiller, Vianney
name: Long, Knox S.
name: Skillman, Evan D.
name: Tumlinson, Jason
name: Whitmore, Bradley C.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We carry out a comparative analysis of the metallicities from the stellar, neutral-gas, and ionized-gas components in the metal-rich spiral galaxy M83. We analyze spectroscopic observations taken with the Hubble Space Telescope (HST), the Large Binocular Telescope (LBT) and the Very Large Telescope (VLT). We detect a clear depletion of the HI gas, as observed from the HI column densities in the nuclear region of this spiral galaxy. We find column densities of log[$N$(HI) cm$^{-2}$] $
description: 29 pages, 14 tables, 9 figures, Accepted for Publication in ApJ
Additional file 3 of Blood pressure and risk of cancer: a Mendelian randomization study
Creators: name: Chan, Io Ieong
name: Kwok, Man Ki
name: Schooling, C. Mary
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: Additional file 3: Supplementary Figure S3. Mendelian randomization estimates of systolic (filled) and diastolic (hollow) blood pressure on asthma.
Bioengineering Stents for Proactive Biocompatibility
Creators: name: Thamarasee Jeewandara
name: Waterhouse, Anna
name: Wise, Steven
name: Kondyurin, Alexey
name: Bilek, Marcela
name: Weiss, Anthony
name: Ng, Martin
Publisher: name: F1000Research
Year: 2015

description: Bioengineering alloy 316L, stainless steel, cardiovascular stent material via applied plasma physics for biocompatibility and pre-clinical applications.
Poster based on abstract accepted to Scientific Sessions American Heart Association, Dallas, Texas, USA 2013. Presented on the 17.11.13 [link to abstract APS.714.03-Femoropopliteal Artery Stenting; Restenosis] Presented as PhD candidate, Sydney Medical School, University of Sydney.
Probing effective nucleon-nucleon interaction at band termination
Creators: name: Satula, Wojciech
Publisher: name: arXiv
Year: 2006
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Low-energy nuclear structure is not sensitive enough to resolve fine details of nucleon-nucleon (NN) interaction. Insensitivity of infrared physics to the details of short-range strong interaction allows for consistent, free of ultraviolet divergences, formulation of local theory at the level of local energy density functional (LEDF) including, on the same footing, both particle-hole as well as particle-particle channels. Major difficulty is related to parameterization of the nuclear LEDF and its density dependence. It is argued that structural simplicity of terminating or isomeric states offers invaluable source of informations that can be used for fine-tuning of the NN interaction in general and the nuclear LEDF parameters in particular. Practical applications of terminating states at the level of LEDF and nuclear shell-model are discussed.
description: Invited talk presented at the XIII Nuclear Physics Workshop, Kazimierz Dolny, Sept. 27 - Oct. 1, Poland; submitted to IJMP E
Stakeholder management of golf course development in the Lower Mainland
Creators: name: Mosher, Michael Ian
Publisher: name: University of British Columbia
Year: 2009

description: In the years 1988-1991, municipal governments in the Lower Mainland dealt with numerous applications from golf course developers seeking to capitalize on the popularity of the game and a projected shortage of golf courses to meet the increased demand for courses to play on. However, it soon became apparent to those same developers that getting approval for a golf course development was a much more involved process than merely having access to land and the finances to develop the golf course. Applications before Lower Mainland municipal councils at the time were to collide with the interests of individuals and groups other than golfers and their benefactor developers. These oppositional groups contested each other through the formal political reviews process. The purpose of this study was threefold. The first objective was to identify key stakeholders in the unfolding golf boom and determine which were most salient. Having determined the most important stakeholders to the process, the next goal was to determine their stake in the golf course development situation. Finally, the third goal of the study was to examine the process concerning the level of stakeholder management which took place. Successful stakeholder management is dependent upon the ability of an organization to manage their relationships with their stakeholder groups in an action oriented manner (Freeman, 1984). By doing so, the organization is attempting to create compatibility between organizational priorities and stakeholder interests. This increases the probability of the organization's success and survival. Three of the original stakeholder groups proposed (developers, local government and environmental and wildlife groups) and one stakeholder not originally identified (the agricultural community) were confirmed as the most salient stakeholder groups. Three stakeholders originally identified were shown to be less important in the process including related businesses, area residents, and golfers. Stakeholder management was not evident through the golf course development process. Developers were viewed as the individuals responsible to control the stakeholder management process, although little evidence of this was found. Instead it was the local councils that were left to balance the arguments from the opposing stakeholders in an issue of land development. Stakeholder management was considered to be of use to a developer if done prior to the submission of their application.
Dual targeting in prostate cancer with phytoconstituents as a potent lead: a computational approach for novel drug discovery
Creators: name: Dhawale, Sachin A.
name: Bhosle, Pallavi
name: Mahajan, Sadhana
name: Patil, Geetanjali
name: Gawale, Sachin
name: Ghodke, Mangesh
name: Tapadiya, Ganesh
name: Ansari, Azim
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Prostate Cancer (PCa) is an abnormal cell growth within the prostate. This condition is the second most widespread malignancy in elderly males and one of the most frequently diagnosed life-threatening conditions. The Androgen receptor signaling pathway played a crucial role in the initiation and spread to increase the risk of PCa. Hence, targeting the AR receptor signaling pathway is a key strategy for a therapeutic plan for PCa. Our study focuses on recognizing potential inhibitors for dual targeting in PCa by using the in-silico approach. In this study, we target the two enzymes that are CYP17A1 (3RUK) and 5α-reductase (3G1R) responsible for PCa, with the help of phytoconstituents. The natural plant contains various phytochemical types produced from secondary metabolites and used as a medical treatment. The in-silico investigation of phytoconstituents and enzymes was done by approaching molecular docking, ADMET analysis, and high-level molecular dynamic simulation used to assess the stability and binding affinities of the protein-ligand complex. Some phytoconstituents, such as Peonidin, Pelargonidin, Malvidin and Berberine show complex has good molecular interaction with protein. The reliability of the docking scores was examined using a molecular dynamic simulation, which revealed that the complex remained stable throughout the simulation, which ranged from 0 to 200 ns. The selected hits may be effective against CYP17A1 (3RUK) and 5α-reductase (3G1R) (PCa) using a computer-aided drug design (CADD) method, which further enables researchers for upcoming in-vivo and in-vitro research, according to our in-silico approach. Communicated by Ramaswamy H. Sarma
Relay Selection & Power Allocation for Maximizing Sum-Throughput of a Buffered Relay Network
Creators: name: Khan, F. A.
name: Malik, Z. A.
name: Nasir, A. A.
name: Masood, M.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Considering two-hop cooperative communication with buffered half-duplex relays, this work jointly optimizes relay selection and transmit power at the relay to maximize the sum-throughput of the network subject to a minimum throughput requirement of each hop and transmit power constraint. The optimization problem is solved and two new buffer aware selection schemes, namely joint relay power allocation and selection scheme (JPASS) and ratio selection scheme (RSS) are proposed. Numerical results show that the average sum-throughput of both the proposed schemes is up to 40% higher compared to the existing schemes in the literature.
Comments on "Reverse auction: the lowest positive integer game"
Creators: name: Flitney, Adrian P.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Combinatorics (math.CO)
subject: History and Overview (math.HO)
subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 91A06, 91B26

description: In Zeng et al. [Fluct. Noise Lett. 7 (2007) L439--L447] the analysis of the lowest unique positive integer game is simplified by some reasonable assumptions that make the problem tractable for arbitrary numbers of players. However, here we show that the solution obtained for rational players is not a Nash equilibrium and that a rational utility maximizer with full computational capability would arrive at a solution with a superior expected payoff. An exact solution is presented for the three- and four-player cases and an approximate solution for an arbitrary number of players.
description: 4 pages
AI Chatbot for Diagnosis of Acute Diseases
Creators: name: Ms. Soumya
name: Syed Mohammed Umairullah
name: Kalyan K S
name: Abhilash S Pole
name: Syed Asif
name: Mohammed Aukib
Publisher: name: Zenodo
Year: 2024

description: This article presents the development of an AI-powered chatbot that can preliminarily diagnose common acute diseases to improve healthcare accessibility in rural areas of India. The chatbot aims to address the shortage of medical professionals in smaller towns and villages where timely healthcare is a persistent challenge. The authors leveraged machine learning algorithms, training them on diverse medical datasets of symptoms, patient history and outcomes related to prevalent acute conditions in rural regions. The model development process focused on techniques to handle limited data, ensuring robust training despite data constraints typical of rural healthcare settings. Rigorous testing was done to validate the chatbot's ability to provide accurate preliminary diagnoses for everyday ailments. Once deployed through voice assistants, smartphones and websites, the AI-driven tool would allow users to input symptoms and receive reliable disease predictions. By overcoming geographical barriers to medical guidance, the chatbot can mitigate escalation of untreated minor illnesses and empower individuals with tools for basic health management. The authors conclude that AI and ML innovations can transform healthcare delivery paradigms if deployed ethically and tailored to the unique needs of underserved communities. This abstract summarizes the key details from the report while avoiding excessive similarity to the original text. Please let me know if you would like me to modify or expand the abstract further.
Novel soliton in dipolar BEC caused by the quantum fluctuations
Creators: name: Andreev, Pavel A.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Solitons in the extended hydrodynamic model of the dipolar Bose-Einstein condensate with quantum fluctuations are considered. This model includes the continuity equation for the scalar field of concentration, the Euler equation for the vector field of velocity, the pressure evolution equation for the second rank tensor of pressure, and the evolution equation for the third rank tensor. Large amplitude soliton solution caused by the dipolar part of quantum fluctuations is found. It appears as the bright soliton. Hence, it is the area of compression of the number of particles. Moreover, it exists for the repulsive short-range interaction.
description: 9 pages, 4 figures
Additional file 1 of The effect of patient education based on health belief model on hospital readmission preventive behaviors and readmission rate in patients with a primary diagnosis of acute coronary syndrome: a quasi-experimental study
Creators: name: Habibzadeh, Hossein
name: Bagherzadi, Aynaz
name: Didarloo, Alireza
name: Khalkhali, Hamidreza
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. TREND Statement Checklist.
Chemoradiotherapy with etoposide, cisplatin, and ifosfamide associated with valproic acid for patients with diffuse intrinsic pontine glioma
Creators: name: Felix, Francisco
name: Juvenia Fontenele
Publisher: name: F1000Research
Year: 2015

description: Children with diffuse intrinsic pontine glioma (DIPG) have very poor prognosis. The overall survival in two years is usually in the range of 5% and virtually no patients have prolonged survival. The only recognized prognostic factors are the age group, the duration of symptoms before diagnosis and treatment with radiotherapy. Only radiation therapy is widely accepted as effective, although many chemotherapy treatments are used associated to or after radiotherapy. Recently, a phase II trial reported results that indicated the efficacy of chemoradiation based on cisplatin, etoposide and ifosfamide, followed by a maintenance chemotherapy based in the COG-934 trial concept (HIT-GBM-D). Since 2012 we have indicated the treatment of patients with DIPG "as per" HIT-GBM-D protocol with adaptations. In addition, our patients used off-label valproic acid, 10-15 mg/ kg/day q8-12h. We retrospectively reviewed the charts of patients that have received this treatment for DIPG in our center since 2012. A total of 9 patients with DIPG were treated "as per" adapted HIT-GBM-D associated with oral valproic acid. Of these, 6 are still alive with follow up times of 16, 13, 6, 5, 4 and 3 months. The survival at 6 months in the group is 86%, and the survival rate at 12 months is 64%. All patients showed significant clinical improvement. At the last update of the follow up, only one of the survivors had presented with progression after initial treatment. The median progression-free survival of this group is 7 months. The median follow-up time for the whole group is 12 months. The radio-chemotherapy with cisplatin, etoposide, ifosfamide, associated with valproic acid seems to have potential in the treatment of patients with DIPG. A "proof of concept" phase II clinical trial would be feasible to test this hypothesis.
Unified electronic phase diagram for hole-doped high-Tc cuprates
Creators: name: Honma, T.
name: Hor, P. H.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Astrophysics (astro-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We have analyzed various characteristic temperatures and energies of hole-doped high-Tc cuprates as a function of a dimensionless hole-doping concentration (pu). Entirely based on the experimental grounds we construct a unified electronic phase diagram (UEPD), where three characteristic temperatures (T*'s) and their corresponding energies (E*'s) converge as pu increases in the underdoped regime. T*'s and E*'s merge together with the Tc curve and 3.5kBTc curve at pu - 1.1 in the overdoped regime, respectively. They finally go to zero at pu - 1.3. The UEPD follows an asymmetric half-dome-shaped Tc curve in which Tc appears at pu - 0.4, reaches a maximum at pu - 1, and rapidly goes to zero at pu - 1.3. The asymmetric half-dome-shaped Tc curve is at odds with the well-known symmetric superconducting dome for La2-xSrxCuO4 (SrD-La214), in which two characteristic temperatures and energies converge as pu increases and merge together at pu - 1.6, where Tc goes to zero. The UEPD clearly shows that pseudogap phase precedes and coexists with high temperature superconductivity in the underdoped and overdoped regimes, respectively. It is also clearly seen that the upper limit of high-Tc cuprate physics ends at a hole concentration that equals to 1.3 times the optimal doping concentration for almost all high-Tc cuprate materials, and 1.6 times the optimal doping concentration for the SrD-La214. Our analysis strongly suggests that pseudogap is a precursor of high-Tc superconductivity, the observed quantum critical point inside the superconducting dome may be related to the end point of UEPD, and the normal state of the underdoped and overdoped high temperature superconductors cannot be regarded as a conventional Fermi liquid phase.
description: 17 pages, 8 figures, and 10 tables. Accepted for the publication of the Physical review B
Changes in free energy barrier for water permeation by stretch-induced phase transitions in phospholipid/cholesterol bilayers
Creators: name: Shigematsu, Taiki
name: Koshiyama, Kenichiro
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Physical Sciences not elsewhere classified
Medicine
Cell Biology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Computational Biology

description: Water permeation through phospholipid/cholesterol bilayers is the key to understanding tension-induced rupture of biological cell membranes. We performed molecular dynamics simulations of stretched phospholipid/cholesterol bilayers to investigate changes in the free energy profile of water molecules across the bilayer and the lipid structure responsible for water permeation. We modeled stretching of the bilayer by applying areal strain. In stretched phospholipid/cholesterol bilayers, the hydrophobic tail of the phospholipids became disordered and the free energy barrier to water permeation decreased. Upon exceeding the critical areal strain, a phase transition to an interdigitated gel phase occurred before rupture, and the hydrophobic tail ordering as well as the free energy barrier were restored. In pure phospholipid bilayers, we did not observe such recoveries. These transient recoveries in the phospholipid/cholesterol bilayer suppressed water permeation and membrane rupture, followed by an increase in the critical areal strain at which the bilayer ruptured. This result agrees with experimental results and provides a reasonable molecular mechanism for the toughness of phospholipid/cholesterol bilayers under tension. Communicated by Ramaswamy H. Sarma
Environmental Effects on Gaseous Disks of the Virgo Spiral Galaxies
Creators: name: Nakanishi, Hiroyuki
name: Kuno, Nario
name: Sofue, Yoshiaki
name: Sato, Naoko
name: Nakai, Naomasa
name: Shioya, Yasuhiro
name: Tosaki, Tomoka
name: Onodera, Sachiko
name: Sorai, Kazuo
name: Egusa, Fumi
name: Hirota, Akihiko
Publisher: name: arXiv
Year: 2006
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We found high molecular fractions ($f_{\rm mol}$; ratio of the molecular to total gas surface densities) in three of five Virgo spiral galaxies in spite of their low total gas column density, based on $^{12}$CO$(J=1-0)$ observations with the Nobeyama 45 m telescope equipped with a multi-beam receiver, BEARS. We interpret this as a result of environmental effects. Combining the CO data with HI data, the relationship between the surface density of the total gas (HI plus H$_2$) and $f_{\rm mol}$ indicates that the three galaxies near the cluster center have larger $f_{\rm mol}$ values than expected for field galaxies, while the others show normal $f_{\rm mol}$. The large $f_{\rm mol}$ is interpreted as being due either to effective HI gas stripping, even in the inner disks, or to large ISM pressure induced by the high ICM pressure and/or ram pressure, although the possibility of an unusually high metallicity cannot be ruled out.
description: 12 pages, 8 figures. To appear in ApJ
ДХХ ЧЕГАРА ҚЎШИНЛАРИНИНГ МАЪМУРИЙ ҲУҚУҚБУЗАРЛИКЛАР ТЎҒРИСИДАГИ ИШЛАРНИ ЮРИТИШ АМАЛИЁТИ ТАҲЛИЛИ
Creators: name: Холбўтаев, Абдуғани
Publisher: name: Zenodo
Year: 2024

description: Мақолада ДХХ Чегара қўшинларининг маъмурий ҳуқуқбузарликлар тўғрисидаги ишларни юритиш амалиётининг айрим масалаларининг таҳлили ёритиб берилган бўлиб, миллий қонунчилик ҳужжатларини кўриб чиқиш натижаларига мувофиқ, Чегара қўшинларининг бу борадаги фаолиятини такомиллаштириш бўйича Ўзбекистон Республикаси Вазирлар Маҳкамасининг тегишли қарорига қўшимча киритилиши юзасидан таклиф билдириб ўтилган.
Nimotuzumab in patients with progressive diffuse intrinsic pontine glioma
Creators: name: Felix, Francisco
name: Veras, Igor
name: Bacalhau, Ana Flávia
name: Juvenia Fontenele
Publisher: name: F1000Research
Year: 2015

description: Diffuse intrinsic pontine glioma (DIPG) is a frequent tumor in children aged 4-9 years, making up about 15% of pediatric intracranial tumors with very poor prognosis and no widely accepted treatment. In the last 40 years, no significant improvement occurred in the treatment of these patients. The only recognized prognostic factors are the age group, the duration of symptoms before diagnosis and radiotherapy. Nimotuzumab is a recombinant humanized monoclonal antibody with high affinity for EGFR, approved for use in our country in patients with progressive DIPG after initial treatment. A clinical phase II trial of nimotuzumab in patients with progressive DIPG showed response in 8/19 evaluable patients, with a median survival of 3 months and 2 patients with prolonged survival. We report two cases of children with progressive DIPG treated with nimotuzumab in our service. Case 1: a female 3-year old patient at diagnosis, with a history of hemiparesis and facial hemiparalysis for less than six months. She underwent chemoradiation (54 Gy) with temozolomide, followed by 9 cycles of monthly temozolomide, with significant clinical improvement . Ten months after diagnosis she had clinical and radiological progression. The patient underwent a new radiotherapy course (45 Gy), then nimotuzumab 150 mg/m2 weekly for a total of 5 doses. The patient died after 6 months from disease progression. Case 2: a female 5-year old patient at diagnosis, with previous mild hemiparesis for less than six months. She underwent chemotherapy with carboplatin and vincristine, with partial improvement, progressing after seven months. She then underwent radiotherapy (54 Gy), following oral chemotherapy with temozolomide (4 cycles) with further improvement, and secondarily progressing 6 months after the initial progression. She then received a new radiotherapy course (27 Gy) followed by nimotuzumab 150 mg/m2 weekly and died four months after. None of the patients had clinical or radiological improvement. Nimotuzumab appears to have activity in patients with progressive DIPG after previous treatment.
Nimotuzumab in a case of recurrent glioblastoma expressing a new EGFR mutation
Creators: name: Felix, Francisco
name: Veras, Igor
name: Nogueira, Cleto
name: Fontenele Juvenia
Publisher: name: F1000Research
Year: 2015

description: Glioblastomas are brain tumors of poor prognosis, unusual in pediatric patients. They have molecular characteristics that differentiate them from adult glioblastomas, as the relative rarity of EGFR amplification and mutations. There is no standard treatment for this disease, and chemoradiation is routinely used, with multiple schemes. Despite efforts to improve treatment of this pathology with multimodality treatment, 5-year overall survival in pediatric patients with this tumor is only 5-10%. Recently, nimotuzumab, a recombinant humanized monoclonal antibody with high affinity for EGFR, was approved for use in our country in pediatric patients with recurrent glioblastoma. A clinical phase II trial of nimotuzumab in children and adolescents with recurrent high-grade gliomas showed activity, with 14/46 patients with objective response and about 4 months of median overall survival. We present a case of a male patient, diagnosed at 5 years of age with a parietal-occipital glioblastoma. After subtotal resection, he was treated with chemoradiation (60 Gy) with temozolomide followed by oral temozolomide for 10 cycles, achieving complete remission. Seventeen months after diagnosis, he relapsed with supra and infratentorial implants, but no recurrence at the primary site. The patient underwent a new radiotherapy course (54 Gy), followed by two cycles of temozolomide, with poor outcome. Two small supratentorial lesions increased about 15 times in 70 days with an estimated doubling time of 8 days. The patient underwent further surgery to reduce tumor mass, with only partial resection. The new pathologic analysis confirmed glioblastoma and identified a deletion of 20 base pairs in exon 20 of the EGFR (p.AA767_H773del) never previously described. Nimotuzumab was initiated at a dose of 150 mg/m2 per week. The patient received 7 weekly doses, with a partial clinical improvement and died 86 days after the second relapse with a stabilized radiological image. This case shows the feasibility of using anti-EGFR Mab treatment for refractory pediatric recurrent glioblastoma, selecting the patients by molecular biology.
ASSESSING ACADEMIC PERFORMANCE IN YOBE STATE: KEY FACTORS AND CHALLENGES IN SOME SELECTED SENIOR SECONDARY SCHOOLS IN YOBE STATE, NIGERIA
Creators: name: Fatima, A. Ibrahim
name: Zainab, M. Abubakar
Publisher: name: NOLAND JOURNALS
Year: 2024
Subjects: Students, Academic performance, Teaching methods, Classroom size, Parental

description: This study investigates factors hindering academic performance in senior secondary schools in Yobe State, Nigeria, focusing on teaching methods, classroom size, and parental economic status. Using Bronfenbrenner's Ecological Systems Theory as a framework, the research explores how these factors impact student outcomes. A quantitative survey design was employed, involving 250 SS 3 students from three schools: Government Secondary School Damaturu, Government Science & Technical College Potiskum, and Government Science & Technical College Azbak, Gashua. A stratified sampling technique ensured a representative sample, with data collected via a validated and reliable questionnaire. Analysis using SPSS revealed that while many students find their teachers' methods effective, there is a strong preference for more interactive approaches. Large classroom sizes were identified as a barrier to student interaction and concentration, and financial constraints were found to significantly limit access to learning resources, particularly for economically disadvantaged students. Based on these findings, the study recommends implementing interactive teaching techniques, improving technology integration, managing classroom sizes more effectively, and providing financial support to disadvantaged students. These strategies aim to enhance academic performance and address the challenges identified in the selected schools
Childhood pleuropulmonary blastoma
Creators: name: Felix, Francisco
name: Azevedo, José Ricardo
name: Feitosa, Marta
name: Bezerra, Maria Da Conceição
name: Souza, Maria Ideleide
name: Fabíola Melo
name: Castro, Selma
Publisher: name: F1000Research
Year: 2015

description: Childhood pleuropulmonary blastoma (PPB) is a rare tumor, divided into type I (cystic), II (cystic and solid) and III (solid). Despite multimodality therapy, the prognosis is guarded. Kukkady et al (2000) state that PPB presents often in the setting of repeated acute respiratory infections. In the series of Lindolfo et al (2000), 11 cases (median age 32 months), with a predominance of males (1.75:1) were reported. Respiratory distress was the main complaint. In 3 cases there were prior reports of benign cystic lesions. Overall survival at 2 years for this series was 72% and event-free survival was 42%. Type II or pleural involvement correlated with poor prognosis. Priest et al (1997) published a review of 50 cases, with slight predominance of females (1.08:1) and significant difference in subtype distribution according to age and type I 14% (median age 10 months), type II 48 % (34 months), type III 38% (44 months). Recurrence occurred in 14% of patients with type I and 46% in types II and III. Distant metastases occurred only in types II and III (30%). 5-year survival was 83% in type I and 42% in types II and III. This case reports a type III PPB in an infant aged 1 year and 10 months that presented with a pleuropulmonary opacity image. It was initially treated as pneumonia with parapneumonic effusion, without success. The staging was T4NXM0, a broad resection (total pneumonectomy) was performed. In less than 45 days the tumor had local recurrence with extensive invasion of the mediastinum and compression of the contralateral lung. Despite the introduction of intensive chemotherapy (VACIfoVp), the evolution occurred inexorably to death. This case pictures the initial presentation and evolution of PPB described in the literature with initial diagnostic confusion with pneumonia with pleural effusion, rapid recurrence after surgery and refractoriness to chemotherapy. This patient was 22 months old, somewhat different than the reported median of 44 months for initial diagnosis of type 3 pleuropulmonary blastoma. We emphasize PPB as a rare differential diagnosis of childhood lung tumors, associated with poor prognosis.

Figure 1: A series of chest radiographs showing (A) image of opacification of the hemithorax with contralateral midline deviation (B) image after total pneumectomy; (C) image about 1 month after resection, showing rapid local recurrence.
Figure 2: Chest CT image shows bulky intrathoracic tumor, predominantly solid.
Additional file 1 of ROMO1 is required for mitochondrial metabolism during preimplantation embryo development in pigs
Creators: name: Zhou, Dongjie
name: Sun, Ming-Hong
name: Lee, Song-Hee
name: Cui, Xiang-Shun
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 1: Figure S1. A. EdU assay and proliferative ability index in control and ROMO1 KD groups. B. Colocalization of cytochrome c and MitoTracker Red in control and ROMO1 KD blastocyst stage embryos. Figure S2. A. Representative confocal images of control, ROMO1 KD, ROMO1 OE and ROMO1 KD + OE 4-cell stage embryos for active mitochondria staining. Scale bars, 20 μm. Significant differences are represented by different capital letters (P
A Morphological Approach to the Pulsed Emission from Soft Gamma Repeaters
Creators: name: Jia, J. J.
name: Huang, Y. F.
name: Cheng, K. S.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present a geometrical methodology to interpret the periodical light curves of Soft Gamma Repeaters based on the magnetar model and the numerical arithmetic of the three-dimensional magnetosphere model for the young pulsars. The hot plasma released by the star quake is trapped in the magnetosphere and photons are emitted tangent to the local magnetic field lines. The variety of radiation morphologies in the burst tails and the persistent stages could be well explained by the trapped fireballs on different sites inside the closed field lines. Furthermore, our numerical results suggests that the pulse profile evolution of SGR 1806-20 during the 27 December 2004 giant flare is due to a lateral drift of the emitting region in the magnetosphere.
description: 7 figures, accepted by ApJ
Multidimensional ethno-racial status in Latin American contexts of mestizaje
Creators: name: Paredes Egúsquiza, Cristian Luis
Publisher: name: The University of Texas at Austin
Year: 2017
Subjects: Ethno-racial status
Mestizaje
Latin America

description: In this dissertation, I propose a framework to explain ethno-racial status in contexts of mestizaje (Spanish for ethno-racial mixture). Ethno-racial status refers to the combination of socially ranked and individually embodied ethno-racial characteristics. These characteristics represent distinct dimensions that should be considered together when analyzing ethno-racial issues in these contexts: phenotype, ancestry, and self-identification. I alternatively interpret self-identification, beyond phenotype and ancestry, as exposure to the beliefs –ethno-racial ideologies– that give meaning to local ethno-racial identities rather than explaining it as a central indicator of race. Using survey data, I investigate whether phenotype is a significant dimension of ethno-racial status in Guatemala. I examine the association between skin color and ethnic self-identification, and differences by ethno-racial characteristics in the perception of skin color discrimination, and in the desire for a whiter skin color. I find evidence of a direct association between skin color and ladino self-identification, a greater perception of skin color discrimination by individuals with more indigenous characteristics, and a direct association between indigenous ancestry, captured by indigenous first language, and the desire for a whiter skin color. These findings reveal the significance of phenotype as a distinct dimension of ethno-racial status in Guatemala beyond ancestry and ethnic self-identification. Next, I examine whether there are significant differences in educational attainment and household possessions by phenotype, ancestry, and self-identification in Peru. I find that indigenous/Afro ancestries and darker skin colors are inversely associated with both socioeconomic outcomes. Moreover, white self-identification compared to mestizo is negatively associated with educational attainment, but positively associated with household possessions. This study unveils ethno-racial ideologies as relevant beliefs that are instrumental in gaining socioeconomic advantages. Afterward, I investigate whether Catholic self-identification is directly associated with non-Afro ethno-racial self-identifications, and whether individuals who self-identify as Catholic are significantly prejudiced against Haitians in the Dominican Republic. I find regional-level evidence of a direct association between Catholic self-identification and non-Afro ethno-racial self-identifications. I also find national- and regional-level evidence of a direct association between Catholic self-identification and prejudice against Haitians. These findings reveal the role of Catholicism as a relevant aspect of racialized Dominicanidad (“Dominican-ness”).
Becker, Harald / Geldbach, Erich u.a. (Hg.), Was hast du, das du nicht empfangen hast?
Creators: name: Voß, Klaus Peter
Publisher: name: Ökumenische Rundschau
Year: 2025

description: Ökumenische Rundschau, Bd. 48 Nr. 2 (1999): Ökumenische Rundschau, Band 48, Heft 2
Bioengineering cobalt chromium cardiovascular stent biomaterial with plasma activated coating, for proactive biocompatibility
Creators: name: Thamarasee Jeewandara
name: Wise, Steven
name: Santos, Miguel
name: Praveesuda Michael
name: Juichien Hung
name: Kondyurin, Alexey
name: Bilek, Marcela
name: Weiss, Anthony
name: Ng, Martin
Publisher: name: F1000Research
Year: 2015

description: Bioengineering alloy L605 ,cobalt chromium, cardiovascular stent material via applied plasma physics for biocompatibility.
Poster based on abstract accepted to Scientific Sessions: Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) 2015. Presented on the 05.05.15 [link to abstract 387, ATVB 2015, 35, A387] Presented as PhD candidate, Sydney Medical School, University of Sydney.
Welker, Michael / Willis, David (Hg.), Zur Zukunft der Reformierten Theologie
Creators: name: V. Kloeden, Gesine
Publisher: name: Ökumenische Rundschau
Year: 2025

description: Ökumenische Rundschau, Bd. 48 Nr. 2 (1999): Ökumenische Rundschau, Band 48, Heft 2
Phycocyanobilin is a new binding partner of human alpha-2-macroglobulin that protects the protein against oxidative stress
Creators: name: Šunderić, Miloš
name: Gligorijević, Nikola
name: Milčić, Miloš
name: Minić, Simeon
name: Nedić, Olgica
name: Nikolić, Milan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: Under simulated physiological conditions, this study investigates the interaction between nutraceutical phycocyanobilin (PCB) and the universal anti-protease protein human alpha-2-macroglobulin (α2M). Extensive molecular docking analyses on multiple α2M conformations, spectroscopic techniques, and α2M activity assays were utilized to examine the complex formation. The results revealed that for every protein conformation, two high energy binding sites exist: the first, conformationally independent, at the interface region between two monomer chains and the second, conformationally dependent, in the pocket composed of amino acids from four distinct domains (TED, RBD, CUB, and MG2) of the single protein chain. Spectrofluorimetric measurements indicated a moderate affinity between α2M and PCB with a moderately high binding constant of 6.3 × 105 M−1 at 25 °C. The binding of PCB to α2M resulted in minor changes in the secondary structure content of α2M. Furthermore, PCB protected α2M from oxidation and preserved its anti-protease activity in the oxidative environment. These findings suggest that PCB binding could indirectly impact the body’s response to oxidative stress by influencing α2M's role in controlling enzyme activity during the inflammatory process. Communicated by Ramaswamy H. Sarma
FLASHING: New high-velocity H$_2$O masers in IRAS 18286$-$0959
Creators: name: Imai, Hiroshi
name: Uno, Yuri
name: Maeyama, Daichi
name: Yamaguchi, Ryosuke
name: Amada, Kei
name: Hamae, Yuhki
name: Orosz, Gabor
name: Gómez, José F.
name: Tafoya, Daniel
name: Uscanga, Lucero
name: Burns, Ross A.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We discovered new high-velocity components of H$_2$O maser emission in one of the "water fountain" sources, IRAS~18286$-$0959, which has been monitored using the Nobeyama 45 m telescope in the new FLASHING (Finest Legacy Acquisitions of SiO- and H$_2$O-maser Ignitions by Nobeyama Generation) project since 2018 December. The maser spectra show new, extremely high expansion velocities ($>$200~km~s$^{-1}$ projected in the line of sight) components, some of which are located symmetrically in the spectrum with respect to the systemic velocity. They were also mapped with KaVA (KVN and VERA Combined Array) in 2019 March. We located some of these maser components closer to the central stellar system than other high velocity components (50--200~km~s$^{-1}$) that have been confirmed to be associated with the known bipolar outflow. The new components would flash in the fast collimated jet at a speed over 300~km~s$^{-1}$ (soon) after 2011 when they had not been detected. The fastest of the new components seem to indicate rapid deceleration in these spectra, however our present monitoring is still too sparse to unambiguously confirm it (up to 50~km~s$^{-1}$yr$^{-1}$) and too short to reveal their terminal expansion velocity, which will be equal to the expansion velocity that has been observed ($v_{\rm exp}\sim$120~km~s$^{-1}$). Future occurrences of such extreme velocity components may provide a good opportunity to investigate possible recurrent outflow ignitions. Thus sculpture of the parental envelope will be traced by the dense gas that is entrained by the fast jet and exhibits spectacular distributions of the relatively stable maser features.
description: 11 pages, 5 figures, 2 tables
White Dwarf Tidal Interactions
Creators: name: Piro, Anthony
Publisher: name: Zenodo
Year: 2019

description: The tidal interactions of white dwarf binaries are crucial for understanding the fates of these systems when they merge, connecting them to different classes of astrophysical explosions and other binary systems. New discoveries of compact white dwarf binaries are putting important constraints on these tidal interactions. In the future, we will hopefully have the opportunity to combine gravitational wave measurements with electromagnetic emission. I will describe theoretical work to help interpret these observations, and provide even better measurements of white dwarf tides.
Identification of backgrounds in the EDELWEISS-I dark matter search experiment
Creators: name: Fiorucci, S.
name: Benoit, A.
name: Berge, L.
name: Blumer, J.
name: Broniatowski, A.
name: Censier, B.
name: Chantelauze, A.
name: Chapellier, M.
name: Chardin, G.
name: Collin, S.
name: Defay, X.
name: De Jesus, M.
name: Deschamps, H.
name: Di Stefano, P.
name: Dolgorouky, Y.
name: Dumoulin, L.
name: Eitel, K.
name: Fesquet, M.
name: Gascon, J.
name: Gerbier, G.
name: Goldbach, C.
name: Gros, M.
name: Horn, M.
name: Juillard, A.
name: Lemrani, R.
name: De Lesquen, A.
name: Lubashevskiy, A.
name: Luca, M.
name: Marnieros, S.
name: Mosca, L.
name: Navick, X. -F.
name: Nollez, G.
name: Olivieri, O.
name: Pari, P.
name: Sanglard, V.
name: Schoeffel, L.
name: Schwamm, F.
name: Stern, M.
name: Yakushev, E.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: This paper presents our interpretation and understanding of the different backgrounds in the EDELWEISS-I data sets. We analyze in detail the several populations observed, which include gammas, alphas, neutrons, thermal sensor events and surface events, and try to combine all data sets to provide a coherent picture of the nature and localisation of the background sources. In light of this interpretation, we draw conclusions regarding the background suppression scheme for the EDELWEISS-II phase.