cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Automatically Learning Fallback Strategies with Model-Free Reinforcement Learning in Safety-Critical Driving Scenarios
Creators: name: Lecerf, Ugo
name: Yemdji-Tchassi, Christelle
name: Aubert, Sébastien
name: Michiardi, Pietro
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: When learning to behave in a stochastic environment where safety is critical, such as driving a vehicle in traffic, it is natural for human drivers to plan fallback strategies as a backup to use if ever there is an unexpected change in the environment. Knowing to expect the unexpected, and planning for such outcomes, increases our capability for being robust to unseen scenarios and may help prevent catastrophic failures. Control of Autonomous Vehicles (AVs) has a particular interest in knowing when and how to use fallback strategies in the interest of safety. Due to imperfect information available to an AV about its environment, it is important to have alternate strategies at the ready which might not have been deduced from the original training data distribution. In this paper we present a principled approach for a model-free Reinforcement Learning (RL) agent to capture multiple modes of behaviour in an environment. We introduce an extra pseudo-reward term to the reward model, to encourage exploration to areas of state-space different from areas privileged by the optimal policy. We base this reward term on a distance metric between the trajectories of agents, in order to force policies to focus on different areas of state-space than the initial exploring agent. Throughout the paper, we refer to this particular training paradigm as learning fallback strategies. We apply this method to an autonomous driving scenario, and show that we are able to learn useful policies that would have otherwise been missed out on during training, and unavailable to use when executing the control algorithm.
description: To appear in proceedings of International Conference on Machine Learning Technologies (ICMLT) 2022
О ФОРМЕ КАПЛИ В ЖИДКОСТИ, СТРАТИФИЦИРОВАННОЙ ПО ПЛОТНОСТИ
Creators: name: ДЕНИСОВА М.О.
name: КОСТАРЕВ К.Г.
Publisher: name: Конвективные течения
Year: 2019
Subjects: КАПЛЯ
ДЕФОРМАЦИЯ
ПОВЕРХНОСТНО-АКТИВНОЕ ВЕЩЕСТВО (ПАВ)
КОНВЕКЦИЯ МАРАНГОНИ
DROP
DEFORMATION
SURFACTANT
MARANGONI CONVECTION

description: Для верификации ряда теоретических работ экспериментально исследована форма капли, находящейся в условиях гидроневесомости в стратифицированой по плотности жидкости. Радиус капли превосходит капиллярный, поэтому капля оказывается деформированной (сжатой по вертикали) под действием силы тяжести. Показано, что степень ее деформации определяется градиентом плотности в окружающей среде, физико-химическими свойствами капли и среды, а также интенсивностью капиллярного движения, возникающего на межфазной границе.
Diagnostic Challenges in Acute Central Nervous System Infections in the 2020s
Creators: name: Schibler, Manuel
Publisher: name: Université de Genève
Year: 2021
Subjects: info:eu-repo/classification/ddc/616

description: Acute central nervous system (CNS) infection can manifest as various distinct entities, according to the affected anatomic structures, hence the terms encephalitis, meningitis, meningoencephalitis, myelitis, encephalomyelitis, amongst others. Most of these syndromes are caused by viruses and bacteria, and less frequently by fungi and parasites. Some CNS diseases are caused by an aberrant immune response to microorganisms. Noninfectious CNS inflammation causes mimicking CNS infection include autoimmunity, as well as drug- related reactions. Given the numerous etiologies, which most often cannot be identified based on clinical manifestations, diagnosing CNS infections is challenging and requires broad knowledge in the field and sharp clinical sense, in order to appropriately tailor diagnostic and therapeutic strategies. This thesis comprises four original publications illustrating two aspects regarding the implication of routine and emerging diagnostic tools that can be used for viral CNS infection diagnosis. The first two deal with the use of high throughput sequencing (HTS) in cases of CNS inflammation of undetermined cause, and the last two exemplify how the judicious application of routine microbiological diagnostic means can help to decipher a complex CMV encephalitis case, as well as to extend the understanding of CNS disease caused by an emerging viral disease, such as COVID-19. This selected work is put into perspective with a more global approach aimed at improving and optimizing CNS infection diagnosis.
STUDY OF MASS TRANSFER BETWEEN A DROPLET AND A CONTINUOUS LIQUID: PRELIMINARY EXPERIMENTAL RESULTS
Creators: name: KARPUNIN, I.E.
name: KOZLOV, N.V.
name: PLOURABOUE, F.
Publisher: name: Конвективные течения
Year: 2019
Subjects: SIMPLY CONNECTED DOMAIN
COAXIAL LAYER
ROTATIONAL OSCILLATIONS
SHEAR FLOW
ОДНОСВЯЗНАЯ ОБЛАСТЬ
КОАКСИАЛЬНЫЙ СЛОЙ
ВРАЩАТЕЛЬНЫЕ КОЛЕБАНИЯ
СДВИГОВОЕ ТЕЧЕНИЕ

description: In the paper, a possibility of excitation of droplet inclusion oscillations in a continuous liquid is considered. For this, we propose to use a container with a simply connected cylindrical cavity that performs rotational oscillations relative to its axis. A theoretical formulation of the problem on the oscillating shear flow in the layer is given. Experimental techniques are developed. Preliminary experimental results demonstrate the possibility of periodic deformation of a liquid drop or an air bubble by means of shear oscillations of the surrounding liquid.
Additional file 1: of Sorafenib versus Transarterial chemoembolization for advanced-stage hepatocellular carcinoma: a cost-effectiveness analysis
Creators: name: Chen, Shuling
name: Peng, Zhenwei
name: Wei, Mengchao
name: Liu, Weifeng
name: Dai, Zihao
name: Wang, Haibo
name: Mei, Jie
name: Cheong, Mingfong
name: Zhang, Hanmei
name: Kuang, Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Literature review of this research which includes study strategy, study selection and data extraction. (DOCX 14 kb)
Additional file 2: of Sorafenib versus Transarterial chemoembolization for advanced-stage hepatocellular carcinoma: a cost-effectiveness analysis
Creators: name: Chen, Shuling
name: Peng, Zhenwei
name: Wei, Mengchao
name: Liu, Weifeng
name: Dai, Zihao
name: Wang, Haibo
name: Mei, Jie
name: Cheong, Mingfong
name: Zhang, Hanmei
name: Kuang, Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Table S1. References used to derive monthly mortality of advanced HCC patients with compensated cirrhosis without progression after TACE. (DOCX 15 kb)
GAK is phosphorylated by c-Src and translocated from the centrosome to chromatin at the end of telophase
Creators: name: Kohshiro Fukushima
name: Wang, Mian
name: Naito, Yoko
name: Uchihashi, Toshihiro
name: Yorika Kato
name: Mukai, Satomi
name: Norikazu Yabuta
name: Nojima, Hiroshi
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Cancer

description: Cyclin G-associated kinase (GAK) harbors a consensus phosphorylation motif (Y412) for c-Src; however, its physiological significance remains elusive. Here, we show that GAK is phosphorylated by c-Src not only at Y412 but also at Y1149. An anti-GAK-pY412 antibody recognized the shifted band of GAK during M phase. Immunofluorescence (IF) showed that GAK-pY412/pY1149 signals were present in the nucleus during interphase, translocated to chromosomes at prophase and prometaphase, moved to centrosomes at metaphase, and finally translocated to chromosomes at the end of telophase, when nuclear membrane formation was almost complete. These subcellular movements of GAK resemble those of DNA licensing factors. Indeed, mass spectrometry identified mini-chromosome maintenance (MCM) 3, an essential component of the DNA licensing system, as one of the association partners of GAK; immunoprecipitation-mediated Western blotting confirmed their association in vivo. These results suggest that the c-Src_GAK_MCM axis plays an important role in cell cycle progression through control of the DNA replication licensing system.
Identification of pharmacological inhibitors of NADPH oxidases for the treatment of oxidative stress-derived pathologies
Creators: name: Jaquet, Vincent
Publisher: name: Université de Genève
Year: 2021
Subjects: info:eu-repo/classification/ddc/616.07

description: Excessive oxidant generation leads to tissue damage through modification of biological macromolecules, cellular membranes and extracellular matrix. This situation of oxidative stress is a key pathological feature of numerous diseases, such as cardiovascular, neurological and fibrotic diseases. Although the sources of oxidants in cells are variable, the family of NADPH oxidases (NOX) has as sole known function to generate reactive oxygen species (ROS). There are seven NOX with various tissue expression. As professional ROS generators in specific tissues, NOX represent pharmacological targets of great interest. The main objective of the research compiled in this thesis was to study the feasibility and therapeutic potential of NOX inhibition. Two studies represent proof of principle studies using NOX-deficient mice to address the roles of several NOX isoforms in cardiovascular disease (myocardial infarction) and neurodegenerative disease (amyotrophic lateral sclerosis). Three other studies focus on the discovery, characterization and validation of novel bioavailable small molecule NOX inhibitors. We identified that NOX1 and NOX2 are important contributors of myocardial damage during the reperfusion phase following myocardial ischemia while NOX4 is not. We also showed that genetic deletion of or pharmacological inhibition of specific NOX isoforms present in the central nervous system did not improve survival or motor function in a mouse model of amyotrophic lateral sclerosis. To support the discovery of novel specific and selective NOX inhibitors, we developed a flowchart of assays to identify and validate a bona fide NOX inhibitor. Application of this validation pipeline elucidated that most of the widely reported NOX inhibitors have a multitarget mode of action and/or interfere with the readouts and are not specific for NOX. Using this approach, we validated the family of N-substituted phenothiazines as general NOX inhibitors as well as a potent and bioavailable compound GSK2795039 specific for the NOX2 isoform. The established screening and validation flowchart will allow identification of novel highly specific NOX inhibitors to enable further validation of NOX as potential drug targets.
Additional file 3: of Sorafenib versus Transarterial chemoembolization for advanced-stage hepatocellular carcinoma: a cost-effectiveness analysis
Creators: name: Chen, Shuling
name: Peng, Zhenwei
name: Wei, Mengchao
name: Liu, Weifeng
name: Dai, Zihao
name: Wang, Haibo
name: Mei, Jie
name: Cheong, Mingfong
name: Zhang, Hanmei
name: Kuang, Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Table S2. References used to derive monthly tumor progression rate of advanced HCC patients with compensated cirrhosis after TACE. (DOCX 14 kb)
Neurological complications in children on ECMO support
Creators: name: Polito, Angelo
Publisher: name: Université de Genève
Year: 2021
Subjects: info:eu-repo/classification/ddc/618

description: Neurological injuries are still a leading cause of morbidity and mortality among critically ill children needing extracorporeal membrane oxygenation support (ECMO). The objective of this manuscript is to review the state of knowledge on the epidemiology and risk factors for neurological injuries during ECMO support in children from a clinical standpoint and to discuss research and quality improvement perspectives.
Additional file 4: of Sorafenib versus Transarterial chemoembolization for advanced-stage hepatocellular carcinoma: a cost-effectiveness analysis
Creators: name: Chen, Shuling
name: Peng, Zhenwei
name: Wei, Mengchao
name: Liu, Weifeng
name: Dai, Zihao
name: Wang, Haibo
name: Mei, Jie
name: Cheong, Mingfong
name: Zhang, Hanmei
name: Kuang, Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Virology

description: Table S3. References used to derive monthly mortality of advanced HCC patients with compensated cirrhosis without progression taking sorafenib in full dose. (DOCX 13 kb)
title: Fouilles de l'oppidum de Gergovie (2022-2025) : « le Quartier des Artisans »
Publisher: name: Maison des Sciences de l’Homme de Clermont-Ferrand
Year: 2023

description: L’Institut national de recherches archéologiques préventives (Inrap) et la Maison des Sciences de l’Homme de Clermont-Ferrand (UAR 3550 / CNRS-UCA) mènent de 2022 à 2025 une opération de fouilles programmées sur l'oppidum de Gergovie (commune de La Roche Blanche, Puy-de-Dôme). Ces fouilles sont conduites sous la tutelle de l'État, en partenariat avec le Conseil départemental du Puy-de-Dôme et le Musée archéologique de la Bataille de Gergovie.
A Facile Synthesis of Naturally Occurring nor-Lignans (±)-Machicendiol and its Analogs
Creators: name: Kishor R. More
name: R. S. Mali
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Computational Biology

description: A facile synthesis of naturally occurring (±)-Machicendiol and analogs have been accomplished in moderate to good yield from 2-aryl-5-formly-7-methoxy-benzofurans via two simple, efficient approaches involving the application of Reformatsky reaction and Claisen condensation.
Synthesis of Marine Alkaloids Leucettamine B and C by β-lactam Ring Rearrangement
Creators: name: Dražić, Tonko
name: Krešimir Molčanov
name: Jurin, Mladenka
name: Roje, Marin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology

description: A new method for the synthesis of marine alkaloids leucettamine B and C from Leucetta sp. sponges is described. The key step is the base-promoted rearrangement of β-lactam into imidazolone ring. Leucettamine B and C, as well as their N-benzoyl derivatives were obtained in high yields. Single crystal structures of both leucettamine B and C were determined by X-ray diffraction confirming Z-configuration of double bond at 4- position of imidazolone.
Additional file 10: of Modulations in the offspring gut microbiome are refractory to postnatal synbiotic supplementation among juvenile primates
Creators: name: Pace, Ryan
name: Prince, Amanda
name: Ma, Jun
name: Belfort, Benjamin
name: Harvey, Alexia
name: Hu, Min
name: Baquero, Karalee
name: Blundell, Peter
name: Takahashi, Diana
name: Dean, Tyler
name: Kievit, Paul
name: Sullivan, Elinor
name: Friedman, Jacob
name: Grove, Kevin
name: Aagaard, Kjersti
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S6. Relative abundance of LEfSe-identified enriched KEGG pathways in the pre-supplemented and mid synbiotic supplemented groups. STAMP generated two groups extended error bar plot. Plots on the left indicate relative abundance of enriched KEGG pathways. Plot on the right indicates the difference in the mean proportion. Statistical significance was tested using Whiteâ s non-parametric t-test. (PDF 260 kb)
Resin-based CAD/CAM materials : Surface stability under simulated clinical conditions
Creators: name: Alharbi, Amal
Year: 2016
Subjects: info:eu-repo/classification/ddc/617.6

description: The major goal of restorative dentistry is to replace the lost tooth substance by a restorative material with tooth-like structure and matching physical and mechanical properties. The long-term surface stability of the restoration determine its clinical success. Advancement in the material manufacturing aim to produce material that will resist mechanical and chemical degradation when placed in function. With the introduction of new CAD/CAM materials, restoration quality has been improved due to a better material structure and a standardized fabrication technique. Based on the results of the in vitro studies performed for this thesis, that assessed the surface resistance of new CAD/CAM and direct composites when confronted to chemical and mechanical challenge. The best performing resin CAD/CAM materials were: the hybrid ceramic “ VITA ENAMIC” and LAVA Ultimate. They showed a surface resistance to staining and degradation that was comparable to feldspathic ceramic. However, their wear resistance was inferior to ceramic. Bleaching of the stained samples made of these materials resulted in stain removal with almost no residual stain remained after bleaching. Tooth brushing and red wine proved to be the most aggressive degradation procedure. The direct hydrophobic composite “Filtek Silorane” behave similar to the best performing resin CAD/CAM materials in term of resistant to degradation.
Additional file 5: of Sorafenib versus Transarterial chemoembolization for advanced-stage hepatocellular carcinoma: a cost-effectiveness analysis
Creators: name: Chen, Shuling
name: Peng, Zhenwei
name: Wei, Mengchao
name: Liu, Weifeng
name: Dai, Zihao
name: Wang, Haibo
name: Mei, Jie
name: Cheong, Mingfong
name: Zhang, Hanmei
name: Kuang, Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Virology

description: Table S4. References used to derive monthly progression rate of advanced HCC patients with compensated cirrhosis taking sorafenib in full dose. (DOCX 13 kb)
Additional file 11: of Modulations in the offspring gut microbiome are refractory to postnatal synbiotic supplementation among juvenile primates
Creators: name: Pace, Ryan
name: Prince, Amanda
name: Ma, Jun
name: Belfort, Benjamin
name: Harvey, Alexia
name: Hu, Min
name: Baquero, Karalee
name: Blundell, Peter
name: Takahashi, Diana
name: Dean, Tyler
name: Kievit, Paul
name: Sullivan, Elinor
name: Friedman, Jacob
name: Grove, Kevin
name: Aagaard, Kjersti
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Table S5. Unweighted and weighted UniFrac PERMANOVA p-values of samples from juveniles before and during the HFD challenge (un15mo, un26mo, P4M, HFD). (PDF 12Â kb)
Self-stigmatization in bipolar disorders: a systematic review
Creators: name: Richard Lepouriel, Hélène
Publisher: name: Université de Genève
Year: 2021
Subjects: info:eu-repo/classification/ddc/616.89
Bipolar disorders
Self-stigma

description: Background: Bipolar disorder is a severe and chronic mental illness characterized by recurrent major depressive episodes and mania or hypomania during the course of the illness. In addition to the burden of the disease and its consequences, people living with severe mental illness have a propensity to selfstigma that is being aware of and internalizing public stigma. This review examines self-stigma in bipolar disorder. Methods: An electronic search was carried out during the last week of August 2020. Three academic databases – PubMed, Embase, and PsycInfo – were systematically searched, based on the PRISMA guidelines. Results: Fifty-six articles concern the question of self-stigma in bipolar disorder. The following key themes emerge from this review: 1/ Comparison of self-stigma in bipolar disorder and other mental illnesses, 2/ Sociocultural context and self-stigma, 3/ Correlates and predictors of self-stigma, 4/ Consequences of self-stigma, 5/ Treatments and self-stigma, 6/ Management of self-stigma, and 7/ Selfstigma and recovery in bipolar disorder. Conclusion: Like many other people with severe mental illness, people living with bipolar disorder are highly self-stigmatized, and this self-stigma has critical impacts on their lives. Some interventions intended to reduce self-stigmatization have been developed but evidence of their effectiveness is still sparse. Clinicians need to be more aware of and attentive to self-stigma, its assessment and its empowerment in their daily clinical practice. Future work is required to establish valid strategies to fight self-stigma.
Additional file 6: of Sorafenib versus Transarterial chemoembolization for advanced-stage hepatocellular carcinoma: a cost-effectiveness analysis
Creators: name: Chen, Shuling
name: Peng, Zhenwei
name: Wei, Mengchao
name: Liu, Weifeng
name: Dai, Zihao
name: Wang, Haibo
name: Mei, Jie
name: Cheong, Mingfong
name: Zhang, Hanmei
name: Kuang, Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Virology

description: Table S5. References used to derive monthly mortality of advanced HCC patients with compensated cirrhosis without progression taking sorafenib in adjusted dose. (DOCX 12 kb)
Precision oncology beyond DNA mutation testing
Creators: name: Tsantoulis, Petros
Publisher: name: Université de Genève
Year: 2021
Subjects: info:eu-repo/classification/ddc/616
Precision oncology
Genomics
Cancer
Biomarkers
Personalized oncology

description:
Precision oncology emerged when genomics and new therapies converged. Genomics grew exponentially, fueled by next-generation sequencing, and gave insights into cancer physiology. This knowledge enabled the rational design of targeted therapies. Precision oncology draws from an understanding of cancer biology and an increasing collection of biomarkers and associated therapies to choose the best treatment for each patient.

Despite the undeniable success of precision oncology in multiple cancers, difficulties remain. Matching a cancer mutation to a single drug has limited utility. Many drugs that succeeded in phase I/II trials failed later phase III trials. Even for effective therapies, predicting who will benefit is difficult. Some have voiced concerns that precision oncology is not feasible outside a few well-publicized examples. Here we suggest a few ways to go forward.

In the first publication, we showed that it is not enough to consider pathogenic mutations of the EGFR gene to predict response to EGFR-directed treatment. Many patients present with concurrent mutations in other genes. Most of these mutations have no apparent effect on treatment response, but some can cause primary resistance via cellular pathways which bypass the drug's action. The second publication showed that lung adenocarcinoma with a low allelic frequency of the EGFR mutation is associated with shorter progression-free survival. The low allelic frequency is an indirect sign of subclonal expansion, meaning that the tumor is heterogeneous. Cancer cells which do not carry the mutation are less likely to respond to therapy.

The third work exemplified the use of copy number analysis in addition to DNA mutation testing. Based on an exceptional case, we presented a hypothesis to explain benefit from treatment with palbociclib and suggested how this can be applied in future trials. In the fourth publication, we developed a multi-cancer biomarker of liver metastasis from gene expression data. Pan-cancer biomarkers are difficult to identify but can reveal underlying biology. Gene expression biomarkers are particularly sensitive to batch effects and other sources of bias and are currently under-utilized.

Several challenges remain. As we showed in the first two publications, the cancer co-mutation patterns and tumor heterogeneity are challenges for the implementation of precision oncology. We believe that the accumulation of data, the integration of algorithmic decision support, and the implementation of new assays will help overcome these difficulties. In accordance with this view, our future projects are focused on biomarker discovery and tumor classification, most recently with the integration of single-cell RNA sequencing and digital pathology.
Additional file 12: of Modulations in the offspring gut microbiome are refractory to postnatal synbiotic supplementation among juvenile primates
Creators: name: Pace, Ryan
name: Prince, Amanda
name: Ma, Jun
name: Belfort, Benjamin
name: Harvey, Alexia
name: Hu, Min
name: Baquero, Karalee
name: Blundell, Peter
name: Takahashi, Diana
name: Dean, Tyler
name: Kievit, Paul
name: Sullivan, Elinor
name: Friedman, Jacob
name: Grove, Kevin
name: Aagaard, Kjersti
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Figure S7. Alterations in bacterial taxa and metabolic pathways are associated with HFD challenge. A. LEfSe generated cladogram of taxonomic differences of abundance. Areas shaded blue indicate bacterial taxa with a higher abundance in prior synbiotic supplemented animals at 4-months post- supplementation, whereas areas shaded purple indicate bacterial taxa with a higher abundance in prior synbiotic supplemented animals during HFD challenge. B. LEfSe plot of bacterial metabolic pathways with differential abundance. Areas to the right and shaded blue indicate bacterial metabolic pathways enriched in synbiotic-supplemented animals at 4-months post-synbiotic, whereas areas to the left and shaded purple indicate bacterial metabolic pathways enriched in prior synbiotic supplemented animals during HFD challenge. C. LEfSe generated cladogram of taxonomic differences of abundance. Areas shaded blue indicate bacterial taxa with a higher abundance in prior synbiotic supplemented animals at 4-months post-treatment, whereas areas shaded green indicate bacterial taxa with a higher abundance in untreated animals during HFD challenge. D. LEfSe plot of bacterial metabolic pathways with differential abundance. Areas to the right and shaded blue indicate inferred bacterial metabolic pathways enriched in synbiotic supplemented animals at 4-months post-treatment, whereas areas to the left and shaded green indicate bacterial metabolic pathways enriched in untreated animals during HFD challenge. (PDF 3901 kb)
Various approaches to postmarketing drug safety monitoring
Creators: name: Ing Lorenzini, Kuntheavy
Publisher: name: Université de Genève
Year: 2021
Subjects: info:eu-repo/classification/ddc/617
Drug safety
Pharmacovigilance

description: Before being launched on the market, a medicinal product must have been demonstrated of good quality, effective and safe. However, rare adverse drug reactions or those occurring after long-term use may not always be detected during the clinical development of a drug. Therefore, continuous drug safety monitoring, or pharmacovigilance, is essential during the whole lifecycle of a drug, including after the market authorization. This thesis provides an overview of different tools available for the postmarketing surveillance of drug safety. Classic pharmacovigilance is based on spontaneous reports of individual cases. Postmarketing studies are also useful to evaluate safety in certain populations (e.g. children, pregnant women, elderly) or to assess the impact of certain risk factors (e.g. pharmacogenetics). On the other hand, drug-drug interaction can lead to toxicity or to therapeutic failure when the systemic exposure of the victim drug is modified by a perpetrator drug. Finally, data and text mining strategies are useful when a large amount of data have to be explored, such as global pharmacovigilance databases, electronic health records, or social media.
Rare Earth Ions Adsorption onto Graphene Oxide Nanosheets
Creators: name: Radwa M. Ashour
name: Abdelhamid, Hani Nasser
name: Abdel-Magied, Ahmed F.
name: Abdel-Khalek, Ahmed A.
name: M. M. Ali
name: A. Uheida
name: Muhammed, Mamoun
name: Xiaodong Zou
name: Joydeep Dutta
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology

description: Graphene oxide (GO) was synthesized and used as a coagulant of rare earth elements (REEs) from aqueous solution. Stability and adsorption capacities were exhibited for target REEs such as La(III), Nd(III), Gd(III), and Y(III). The parameters influencing the adsorption capacity of the target species including contact time, pH, initial concentration, and temperature were optimized. The adsorption kinetics and thermodynamics were studied. The method showed quantitative recovery (99%) upon desorption using HNO3 acid (0.1 M) after a short contact time (15 min).
Modeling of the nonlinear flame response of a Bunsen-type flame via multi-layer perceptron
Creators: name: Tathawadekar, Nilam
name: Doan, Nguyen Anh Khoa
name: Silva, Camilo F.
name: Thuerey, Nils
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: This paper demonstrates the ability of neural networks to reliably learn the nonlinear flame response of a laminar premixed flame, while carrying out only one unsteady CFD simulation. The system is excited with a broadband, low-pass filtered velocity signal that exhibits a uniform distribution of amplitudes within a predetermined range. The obtained time series of flow velocity upstream of the flame and heat release rate fluctuations are used to train the nonlinear model using a multi-layer perceptron. Several models with varying hyperparameters are trained and the dropout strategy is used as regularizer to avoid overfitting. The best performing model is subsequently used to compute the flame describing function (FDF) using mono-frequent excitations. In addition to accurately predicting the FDF, the trained neural network model also captures the presence of higher harmonics in the flame response. As a result, when coupled with an acoustic solver, the obtained neural network model is better suited than a classical FDF model to predict limit cycle oscillations characterized by more than one frequency. The latter is demonstrated in the final part of the present study. We show that the RMS value of the predicted acoustic oscillations together with the associated dominant frequencies are in excellent agreement with CFD reference data.
Additional file 7: of Sorafenib versus Transarterial chemoembolization for advanced-stage hepatocellular carcinoma: a cost-effectiveness analysis
Creators: name: Chen, Shuling
name: Peng, Zhenwei
name: Wei, Mengchao
name: Liu, Weifeng
name: Dai, Zihao
name: Wang, Haibo
name: Mei, Jie
name: Cheong, Mingfong
name: Zhang, Hanmei
name: Kuang, Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Virology

description: Table S6. References used to derive monthly progression rate of advanced HCC patients with compensated cirrhosis taking sorafenib in adjusted dose. (DOCX 12 kb)
Flavonoids with hepatoprotective activity from the leaves of Cleome viscosa L.
Creators: name: Nguyen, Tan Phat
name: Tran, Cong Luan
name: Vuong, Chi Hung
name: Do, Thi Hong Tuoi
name: Le, Tien Dung
name: Mai, Dinh Tri
name: Phan, Nhat Minh
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: One new flavonol glycoside named visconoside C (1), together with seven known flavonol glycosides, quercetin 3-O-β-d-glucopyranoside 7-O-α-l-rhamnopyranoside (2), quercetin 7-O-α-l-rhamnopyranoside (3), astragalin (4), kaempferol 3-O-(4-O-acetyl)-α-l-rhamnopyranoside (5), kaempferol 7-O-α-l-rhamnopyranoside (6), kaempferitrin (7) and kaempferol 3-O-β-d-glucopyranoside 7-O-α-l-rhamnopyranoside (8) were isolated by various chromatography methods from the leaves of Cleome viscosa L. Their structures were elucidated by IR, UV, HR-ESI-MS and NMR (1D & 2D) experiments. The cytotoxicity and hepatoprotective activities using HepG2 human hepatoma cell line of 1 were measured by MTT assay. At the concentration of 25 μM and 50 μM, 1 showed cytotoxic activity against HepG2 cells (cell viability was decreased to 22.2 and 23.0%, respectively, compared with doxorubicin control), while at the concentration of 100 μM, 1 showed hepatoprotective activity against CCl4-induced hepatotoxicity on HepG2 cells (34.3%, compared with quercetin control).
Is the Intracrinology of Endometriosis Relevant in Clinical Practice?
Creators: name: Pluchino, Nicola
Publisher: name: Université de Genève
Year: 2019
Subjects: info:eu-repo/classification/ddc/618

description: Endometriosis has been traditionally viewed as a hormone-dependent disease where gonadic estrogens stimulate the proliferation of endometriosis implants, enhance chronic inflammation and prompt painful symptoms. Recently a more comprehensive understanding of this disease profiles endometriosis as an abnormal hormonal microenvironment characterized by increased estrogen responsiveness, progesterone resistance and aberrant estrogens synthesis and metabolism. This latter feature, other way defined intracrinology, plays a crucial role in sustaining the loop between estrogens, inflammation and pain. Further profiling intracrinology in endometriosis offers new basis for phenotypic characterization of the disease, drives the understanding of potential mechanisms of drug resistance and identifies new therapeutic targets.
Additional file 8: of Sorafenib versus Transarterial chemoembolization for advanced-stage hepatocellular carcinoma: a cost-effectiveness analysis
Creators: name: Chen, Shuling
name: Peng, Zhenwei
name: Wei, Mengchao
name: Liu, Weifeng
name: Dai, Zihao
name: Wang, Haibo
name: Mei, Jie
name: Cheong, Mingfong
name: Zhang, Hanmei
name: Kuang, Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Table S7. References used to derive monthly mortality of patients with compensated cirrhosis and progressive HCC after TACE. (DOCX 13 kb)
Additional file 13: of Modulations in the offspring gut microbiome are refractory to postnatal synbiotic supplementation among juvenile primates
Creators: name: Pace, Ryan
name: Prince, Amanda
name: Ma, Jun
name: Belfort, Benjamin
name: Harvey, Alexia
name: Hu, Min
name: Baquero, Karalee
name: Blundell, Peter
name: Takahashi, Diana
name: Dean, Tyler
name: Kievit, Paul
name: Sullivan, Elinor
name: Friedman, Jacob
name: Grove, Kevin
name: Aagaard, Kjersti
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S8. Relative abundance of LEfSe-identified enriched KEGG pathways in the synbiotic supplemented and untreated groups during HFD challenge. STAMP generated two groups extended error bar plot. Plots on the left indicate relative abundance of enriched KEGG pathways. Plot on the right indicates the difference in the mean proportion. Statistical significance was tested using Whiteâ s non-parametric t-test. (PDF 461 kb)
New cytotoxic furan from the marine sediment-derived fungi Aspergillus niger
Creators: name: Uchoa, Paula Karina S.
name: Pimenta, Antonia T. A.
name: Braz-Filho, Raimundo
name: Oliveira, Maria Da Conceição F. De
name: Saraiva, Natália N.
name: Rodrigues, Barbara S. F.
name: Pfenning, Ludwig H.
name: Abreu, Lucas M.
name: Wilke, Diego V.
name: Florêncio, Katharine G. D.
name: Lima, Mary Anne S.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: A fungal strain of Aspergillus niger was recovered from sediments collected in the Northeast coast of Brazil (Pecém’s offshore port terminal). Cultivation in different growth media yielded a new ester furan derivative, 1, along with malformin A1, malformin C, cyclo (trans-4-hydroxy-L-Pro-L-Leu), cyclo (trans-4-hydroxy-L-Pro-L-Phe), cyclo (L-Pro-L-Leu), cyclo (L-Pro-L-Phe), pseurotin D, pseurotin A, chlovalicin, cyclo (L-Pro-L-Tyr) and cyclo (L-Pro-L-Val). Compound 1 was cytotoxic against HCT-116 cell line, showing IC50 = 2.9 μg/mL (CI 95% from 1.8 to 4.7 μg/mL).
The handle of literacy: evidence from preliterate children and illiterate adults on orientation discrimination of graspable and non-graspable objects
Creators: name: Fernandes, Tânia
name: Coelho, Bárbara
name: Lima, Fanny
name: São Luís Castro
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Prior research reported an apparently developmental trajectory on mirror-image discrimination (Gregory, Landau, & McCloskey, 2011): reflections across the object principal axis (OPA) and across the external vertical axis (EVA) are hard to discriminate by children, but only OPA reflections are problematic for adults. In this study, we investigated how literacy acquisition and object visuomotor properties affect this trajectory. Six-year-old children (preliterate preschoolers vs. first graders: Experiment 1) and illiterate, ex-illiterate, and schooled literate adults (Experiment 2), searched for graspable (e.g. hammer) or non-graspable (e.g. sock) target-objects amongst orientation-contrast distractors. OPA and EVA errors were predominant in non-readers, but EVA errors dropped sharply in readers. Graspability enhanced OPA and EVA mirror-image discrimination, especially in non-readers. Thus, the reduction of EVA mirror-image errors is not driven by maturation, cognitive development, or schooling; the underlying mechanisms are mostly learning to read and to a smaller extent the operation of the dorsal stream.
Inflammatory markers: are they reliable predictors of severe bacterial infections in children ?
Creators: name: Galetto-Lacour, Annick
Publisher: name: Université de Genève
Year: 2010
Subjects: info:eu-repo/classification/ddc/618
Fever without a source
Severe bacterial infections
Children
Bacteremia
Meningitis
Pyelonephritis
Pneumonia
Procalcitonin
C-reactive protein
Risk index score

description: Children arriving at the emergency department with fever is a fairly common problem in pediatric practice and the pediatrician has to detect the minority of those children with severe bacterial infection. Rapid diagnosis and treatment of these severe infections is essential since a delay in the management may lead to poorer outcome. The inflammatory markers: procalcitonin and C-reactive protein are reliable markers of severe bacterial infections such as bacteremia, meningitis, pyelonephritis and bacterial pneumonia. We created a score utilizing both procalcitonin and C-reactive protein. This Lab-score has been tested and validated as the best marker of severe bacterial infections in children with fever without a source.
Structure elucidation and NMR assignments of a new triterpenoid from Ixeris chinensis
Creators: name: Shuyan Li
name: Qinghu Wang
name: Baiyinmuqier Bao
name: Jingjing Han
name: Jiesi Wu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Plant Biology

description: A new triterpenoid, namely 3β-hydroxy-13β,28-epoxyolean-11-enyl trans-caffeate (1), was isolated from the EtOAc extract from Ixeris chinensis Nakai. The structures of 1 were elucidated by spectroscopic methods, including UV, IR, HR-ESI-MS and extensive 1D and 2D NMR techniques.
H2020 NanoCommons Transnational Access Services: Data management in nanosafety research. From bench to database thus streamlining analysis and publication
Creators: name: Papadiamantis, Ananstasios
name: Lynch, Iseult
Publisher: name: Zenodo
Year: 2020
Subjects: transnational access, research e-infrastructure, nanosafety, data management, nanomaterials

description: This UoB Transnational Access service is focussed on services related to dataset management and accessibility - including the use of electronic laboratory notebooks, the annotation of existing datasets with ontology terms to facilitate the dataset integration into the NanoCommons database, support in the analysis of datasets from a statistical viewpoint, and support in making data FAIR - Findable, Accessible, Interoperable and Re-usable. Our data management services span the entire data lifecycle - from experimental design through data generation, analysis and storage, linking to experimental protocols and bibliographic metadata, and long-term deposition of datasets. Services can be accessed individually or as a packaged tailored to individual needs. Services are applicable to individual datasets or to entire portfolios of data arising from research projects or teams.
Additional file 9: of Sorafenib versus Transarterial chemoembolization for advanced-stage hepatocellular carcinoma: a cost-effectiveness analysis
Creators: name: Chen, Shuling
name: Peng, Zhenwei
name: Wei, Mengchao
name: Liu, Weifeng
name: Dai, Zihao
name: Wang, Haibo
name: Mei, Jie
name: Cheong, Mingfong
name: Zhang, Hanmei
name: Kuang, Ming
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Virology

description: Table S8. References used to derive monthly mortality of patients with compensated cirrhosis and progressive HCC taking sorafenib in full dose or adjusted dose. (DOCX 12 kb)
Probing the Ellis-Bronnikov wormhole geometry with a scalar field: clouds, waves and Q-balls
Creators: name: Blázquez-Salcedo, Jose Luis
name: Dariescu, Marina-Aura
name: Dariescu, Ciprian
name: Radu, Eugen
name: Stelea, Cristian
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The Ellis-Bronnikov solution provides a simple toy model for the study of various aspects of wormhole physics. In this work we solve the Klein-Gordon equation in this background and find an exact solution in terms of Heun's function. This may describe 'scalar clouds' ($i.e.$ localized, particle-like configuration) or scalar waves. However, in the former case, the radial derivative of the scalar field is discontinuous at the wormhole's throat (except for the spherical case). This pathology is absent for a suitable scalar field self-interaction, and we provide evidence for the existence of spherically symmetric and spinning Q-balls in a Ellis-Bronnikov wormhole background.
description: 11 pages, 3 figures