cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Χρηματοδοτικά Εργαλεία στη Τοπική Αυτοδιοίκηση, Νέες πηγές χρηματοδότησης, Αξιολόγηση και προτάσεις Πολιτικής.
title: Financing Tools in Local Government, New sources of financing, Evaluation and Policy proposals.
titleType: AlternativeTitle
Creators: name: Μοσχίδης, Μιχαήλ
Publisher: name: Πανεπιστήμιο Πελοποννήσου
Year: 2024
Subjects: subject: Τοπική Αυτοδιοίκηση--Ελλάδα
subject: Οργανισμός Τοπικής Αυτοδιοίκησης
subject: Χρηματοδοτικά Εργαλεία
subject: Δημοτικά Ομόλογα
subject: Αυτοτέλεια
subject: Έσοδα

description: Σκοπός της παρούσης εργασίας είναι να παρουσιασθούν τα χρηματοδοτικά εργαλεία που έχουν χρησιμοποιηθεί τα τελευταία χρόνια από την Τοπική Αυτοδιοίκηση και η ανάδειξη των νέων μορφών Χρηματοδότησης της και ειδικότερα των Δημοτικών Ομολόγων. Αρχικά επιχειρείται μια σύντομη παρουσίαση τόσο του Θεσμού της Τοπικής Αυτοδιοίκησης αλλά και των αλλαγών που επήλθαν σε νομοθετικό πλαίσιο στην δυνατότητα χρηματοδότησης των Οργανισμών Τοπικής Αυτοδιοίκησης στην Ελλάδα, κυρίως, και στην Ευρώπη. Στη συνέχεια της εργασίας αναφέρονται τα Χρηματοδοτικά Εργαλεία που συνέβαλλαν τα τελευταία χρόνια στην ανάπτυξη και λειτουργία των ΟΤΑ και θα παρουσιαστούν νέες πηγές και τάσεις χρηματοδότησης. Δίνεται ο ορισμός για τα Δημοτικά Ομόλογα, τα χαρακτηριστικά τους, η διαδικασία έκδοσης - διάθεσης, τα οφέλη και ο κίνδυνος αυτών και παρουσιάζεται η «Αγορά» μέσα από την διεθνή εμπειρία. Ακολουθεί η Αξιολόγηση - παράθεση καλών πρακτικών αλλά και των προβλημάτων που αντιμετώπισαν οι ΟΤΑ χωρών που χρησιμοποίησαν τα διάφορα χρηματοδοτικά εργαλεία, με έμφαση στα Ομόλογα και εξάγονται συμπεράσματα για τους μηχανισμούς υποστήριξης, το ρυθμιστικό πλαίσιο και την αξιολόγηση των προϋποθέσεων για τις περιφέρειες και δήμους που έχουν τη δυνατότητα να αξιοποιήσουν αυτό το χρηματοδοτικό εργαλείο. Το συμπέρασμα είναι ότι δεν είναι ανάγκη στην Ελλάδα να δημιουργηθούν νέοι υποστηρικτικοί μηχανισμοί αλλά θα πρέπει να αξιοποιηθούν το Ταμείο Παρακαταθηκών και Δανείων, η Ελληνική Εταιρεία Τοπικής Ανάπτυξης και Αυτοδιοίκησης ΑΕ και η Επιτροπή Κεφαλαιαγοράς. Είναι σημαντικό επίσης αφού θεσπιστεί ένα διαυγές ρυθμιστικό πλαίσιο να γίνει αξιολόγηση, με ιδιωτικοοικονομικά κριτήρια, ποιοι ΟΤΑ έχουν την επάρκεια αλλά και τους συμφέρει, να αξιοποιήσουν αυτό το επενδυτικό - χρηματοδοτικό εργαλείο.
Relativistic quantum kinetic equation of the Vlasov type for systems with internal degrees of freedom
Creators: name: Smolyansky, S. A.
name: Prozorkevich, A. V.
name: Schmidt, S.
name: Blaschke, D.
name: Roepke, G.
name: Toneev, V. D.
Publisher: name: arXiv
Year: 1997
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We present an approach to derive a relativistic kinetic equation of the Vlasov type. Our approach is especially reliable for the description of quantum field systems with many internal degrees of freedom. The method is based on the Heisenberg picture and leads to a kinetic equation which fulfills the conservation laws. We apply the approach to the standard Walecka Lagrangian and an effective chiral Lagrangian.
description: 11 pages, LaTeX, uses ijmpel.sty
Pre-maximum and maximum of Novae: The spectroscopic observations of Nova ASASSN-17hx
Creators: name: Poggiani, Rosa
Publisher: name: arXiv
Year: 2018
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The coverage of the pre-maximum stage of novae is sparse, with the exception of a few slow novae where the pre-maximum duration is of the order of some weeks. This paper discusses the main features of novae during the pre-maximum and the maximum stages and reports the preliminary results of an investigation of ASASSN-17hx, a peculiar nova that showed a long pre-maximum and secondary brightenings.
description: Proceedings of a talk given at the conference "The Golden Age of Cataclysmic Variables and Related Objects IV (GOLDEN 2017)", 11-16 September, 2017, Palermo, Italy; 9 pages, 8 figures
Pheidole humeridens Wilson, 2003, new species
Creators: name: Wilson, E. O.
Publisher: name: Harvard University Press
Year: 2003
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole humeridens

description: Pheidole humeridens new species
Types Mus. Comp. Zool. Harvard.
etymology L humeridens, shoulder-tooth.
Diagnosis A member of the fallax group similar in various characters to the species listed above, differing as follows. Major: humerus dentate; rugoreticulum on sides of head extends to halfway between eyes and level of occiput; mid-occiput transversely carinulate; antennal scapes reach halfway between eyes and level of occiput; anterior edge of pronotum and all of propodeal dorsum transversely carinulate; in side view, propodeal spines short, vertical to basal propodeal face; from above, postpetiole oval.
Minor: bicolored (see below); humerus toothed; propodeal tooth small and thin; propodeal dorsum carinulate; occiput in full-face view flat.
Measurements (mm) Holotype major: HW 1.50, HL 1.56, SL 1.02, EL 0.26, PW 0.78. Paratype minor: HW 0.74, HL 0.80, SL 0.94, EL 0.20, PW 0.46.
COLOR Major: brownish yellow, with rear halves of gastral tergites changing to light brown..
Minor: bicolored, with head, gaster, and pronotal dorsum medium brown, and rest of body and appendages brownish yellow.
range Known only from the type locality.
Biology At the type locality humeridens colonies occupied conspicuous mound nests in a heavily grazed pasture.
Figure Upper: holotype, major. Lower: paratype, minor. ARGENTINA: Buenos Aires (James C. Trager). Scale bars = 1 mm.
description: Published as part of Wilson, E. O., 2003, Pheidole in the New World. A dominant, hyperdiverse ant genus., Cambridge, MA :Harvard University Press on page 301
IEA Wind Task 52 - 18 m/s Hurdles report - Low Hanging Winds Team
Creators: name: Silveira, Victor
name: Franco, Ignacio
name: González Borges, Joaquín
Publisher: name: Zenodo
Year: 2024

description: In the context of the IEA Summer Games Task 52, our work focuses on the development of lidar-assisted controllers (LAC) for wind turbines, a technology that promises to revolutionise wind energy management. Since wind characteristics are dynamic and subject to sudden changes, conventional control systems often react with delay, which can affect turbine efficiency and performance.

Our approach proposes an LAC system that uses advance information about wind conditions, allowing the turbine to proactively adapt to variations before they impact its operation. This approach not only improves efficiency, but also minimises mechanical wear and tear on the turbine, extending its lifetime.

During the development of this work, we have used open source tools to implement lidar data processing algorithms, which facilitates accessibility and collaboration in the community. Through this research, we aim to contribute to the advancement of LAC technology and promote practices that simplify its application in industry.

We hope that our work will inspire new ideas and collaborations during the Summer Games, and that together we can move towards a more efficient and sustainable future in wind energy.
title: ADCO, Premier cartulaire de Saint-Étienne de Dijon (XIIe siècle), Cart. 21 (G 125), 71 folios, f. 00059
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Premier cartulaire de Saint-Étienne de Dijon (XIIe siècle), Archives départementales de la Côte-d'Or, Cart. 21 (G 125), 71 folios, f. 00059, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Premier cartulaire de Saint-Étienne de Dijon (XIIe siècle), Archives départementales de la Côte-d'Or, Cart. 21 (G 125), 71 folios, f. 00059, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Deep Learning of Vortex Induced Vibrations
Creators: name: Raissi, Maziar
name: Wang, Zhicheng
name: Triantafyllou, Michael S.
name: Karniadakis, George Em
Publisher: name: arXiv
Year: 2018
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Computational Engineering, Finance, and Science (cs.CE)
subject: Machine Learning (cs.LG)
subject: Analysis of PDEs (math.AP)
subject: Machine Learning (stat.ML)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: Vortex induced vibrations of bluff bodies occur when the vortex shedding frequency is close to the natural frequency of the structure. Of interest is the prediction of the lift and drag forces on the structure given some limited and scattered information on the velocity field. This is an inverse problem that is not straightforward to solve using standard computational fluid dynamics (CFD) methods, especially since no information is provided for the pressure. An even greater challenge is to infer the lift and drag forces given some dye or smoke visualizations of the flow field. Here we employ deep neural networks that are extended to encode the incompressible Navier-Stokes equations coupled with the structure's dynamic motion equation. In the first case, given scattered data in space-time on the velocity field and the structure's motion, we use four coupled deep neural networks to infer very accurately the structural parameters, the entire time-dependent pressure field (with no prior training data), and reconstruct the velocity vector field and the structure's dynamic motion. In the second case, given scattered data in space-time on a concentration field only, we use five coupled deep neural networks to infer very accurately the vector velocity field and all other quantities of interest as before. This new paradigm of inference in fluid mechanics for coupled multi-physics problems enables velocity and pressure quantification from flow snapshots in small subdomains and can be exploited for flow control applications and also for system identification.
description: arXiv admin note: text overlap with arXiv:1808.04327
Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor kappa B requires Raf-1.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: The transcription factor nuclear factor kappa B (NF-kappa B) is sequestered in the cytoplasm of most cell types where it is complexed with its inhibitor (I kappa B). A large variety of agents, including growth factors, the tumor promoter phorbol 12-myristate 13-acetate, and the cytokine tumor necrosis factor alpha, initiate signal transduction pathways that converge upon the NF-kappa B-I kappa B complex, resulting in the dissociation of I kappa B and the translocation of NF-kappa B to the nucleus. It has been demonstrated that the phosphorylation of I kappa B is associated with NF-kappa B activation, although the kinase(s) responsible for this process in vivo remain unknown. Here we demonstrate that expression of activated forms of the GTP-binding protein Ras or of the serine/threonine kinase Raf-1 results in the activation of transcription specifically through kappa B sites. This activation appears to be dependent on NF-kappa B, since co-expression of I kappa B alpha eliminates both Ras- and Raf-1-induced transcription. In addition, through the use of a dominant negative form of Raf-1, we show that Raf-1 is a common component utilized by multiple inducers in kappa B site-driven gene expression. These results illuminate a signal transduction pathway in which NF-kappa B/Rel family members participate and also implicate a pathway responsible for kappa B site-dependent gene expression during cell growth and in immune and inflammatory responses.
Matrix Elements of Electroweak Penguin Operators in the 1/Nc Expansion
Creators: name: Knecht, M.
name: Peris, S.
name: de Rafael, E.
Publisher: name: arXiv
Year: 1998
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: It is shown that the K -> pi pi matrix elements of the four-quark operator Q_7, generated by the electroweak penguin-like diagrams of the Standard Model, can be calculated to first non-trivial order in the chiral expansion and in the 1/Nc expansion. Although the resulting B factors B_7^(1/2) and B_7^(3/2) are found to depend only logarithmically on the matching scale, mu, their actual numerical values turn out to be rather sensitive to the precise choice of mu in the GeV region. We compare our results to recent numerical evaluations from lattice-QCD and to other model estimates.
description: 10 pages, LateX, two figures (inserted). Improved comparison with the lattice results. Results unchanged
Corrigendum to "Coupling the SO(2) supergravity through dimensional reduction" [Phys. Lett. B 96 (1-2) (1980) 89-93]
Creators: name: Chamseddine, Ali H.
name: Nicolai, Hermann
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Due to renewed interest in D=5 supergravity and its quartic fermionic terms, fuelled by very recent work on supersymmetric quantum cosmology we correct an error in eq.(4) of the paper cited in the title. We also give the Lagrangian in second order formalism which was not explicitly written out before.
description: Erratum, 2 pages, Phys. Lett. B in Press
Reparative Exonomics: A Blueprint for Global Justice and Collective Prosperity
Creators: name: Christian Ortiz
Publisher: name: Zenodo
Year: 2024

description: This publication introduces Reparative Exonomics, a transformative and decolonial economic framework designed to address centuries of exploitation and systemic injustice across the globe. Through a holistic approach, Reparative Exonomics redefines wealth not as something to be hoarded by individuals or corporations, but as a collective resource that must flow outward—repairing the social, cultural, and economic harms caused by colonialism and capitalism. By focusing on Diversity, Equity, Inclusion, Belonging, and Accessibility (DEIBA) principles, this framework emphasizes tailored reparative solutions for marginalized communities, particularly those in Palestine, Native American nations, African countries, and Latin American Indigenous and Afro-descendant populations.

The article outlines the practical applications of Reparative Exonomics, including cultural restoration, land reparations, and economic justice, all driven by community-led initiatives and Reparative Wealth Funds. It argues that true reparations must go beyond financial compensation, addressing the deep-seated erasure of culture, identity, and autonomy faced by colonized peoples. By integrating historical accountability with sustainable development, Reparative Exonomics offers a path toward restorative justice, cultural sovereignty, and global equity. Through this revolutionary framework, the article envisions a future where wealth and resources are used to heal and empower, rather than exploit and extract.
Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain.
Creators: name: Erickson, Bruce W
name: Burridge, Keith
name: Otey, Carol A
name: Vasquez, Gregory B
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: The actin cross-linking protein alpha-actinin binds to the cytoplasmic domain of the beta 1 subunit of integrin, suggesting that alpha-actinin may form a direct link between the actin cytoskeleton and the transmembrane fibronectin receptor. In this study, we have used short synthetic peptides to localize the binding site for alpha-actinin within the cytoplasmic domain of beta 1 integrin. Four 13-residue peptides were tested in both an affinity chromatographic assay and a solid-phase binding assay. The results indicated that two regions of sequence contribute to the binding of alpha-actinin: one near where the beta 1 cytoplasmic tail emerges from the membrane and a second segment located near the C terminus of the cytoplasmic tail. This binding pattern was investigated in more detail using an adaptation of the mimotope assay, in which each of the 32 overlapping sequential decapeptide segments from the beta 1 cytoplasmic domain was assembled on the head of a different plastic pin. The peptide-pin constructs were used to detect the binding of 125I-alpha-actinin. As predicted from our initial results, alpha-actinin was found to bind to two distinct clusters of peptide segments. This represents a novel use of the mimotope pin assay to map interactive sites on structural proteins.
Modulation by vitamin B6 of glucocorticoid receptor-mediated gene expression requires transcription factors in addition to the glucocorticoid receptor.
Creators: name: Allgood, Victoria
name: Cidlowski, JA
name: Oakley, RH
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: We have investigated the mechanism by which vitamin B6 acts to modulate steroid hormone-mediated gene expression. We show that the level of glucocorticoid-induced gene expression from simple promoters, containing only hormone response elements and a TATA sequence, was not affected by alterations in intracellular vitamin B6 concentration. However, modulation of hormone-induced gene expression was restored with the inclusion of a binding site for the transcription factor nuclear factor 1 (NF1) within the hormone-responsive promoter; glucocorticoid-induced gene expression was reduced by 44% under conditions of elevated intracellular vitamin B6 concentration and enhanced by 98% in mild vitamin deficiency. Under these conditions, neither glucocorticoid receptor sedimentation characteristics, receptor activation, nor DNA binding capacity was affected. Quantitatively analogous effects were detected with estrogen-induced gene expression when an NF1 binding site was removed from or introduced into an estrogen-responsive promoter. NF1-mediated constitutive transcription was not affected by alterations in vitamin concentration. The modulatory effect of vitamin did not require strict positioning of or spacing between the glucocorticoid response element and NF1 binding site. Moreover, a heterologous transcriptional activator, composed of the viral E1a transactivation domain and the GAL4 DNA binding domain, does not substitute for NF1 in restoring vitamin B6 modulation of hormone-induced gene expression. These results suggest that vitamin B6 modulates steroid hormone-mediated gene expression through its influence on a functional or cooperative interaction between steroid hormone receptors and the transcription factor NF1.
title: ADCO, Cart. 186 (11 H 71), f. 0465r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, t. II (XVe siècle), tome II, Archives départementales de la Côte-d'Or, C
art. 186 (11 H 71). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, t. II (XVe siècle), tome II, Archives départementales de la
 Côte-d'Or, Cart. 186 (11 H 71), f. 0465r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-
project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Molecular characterization and outer membrane association of a Chlamydia trachomatis protein related to the hsp70 family of proteins.
Creators: name: MORGAN, M.
name: RAULSTON, J.
name: WYRICK, P.
name: DAVIS, C.
name: SCHMIEL, D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: One route by which Chlamydia trachomatis is internalized into host endometrial epithelial cells is receptor-mediated endocytosis. Although this implies an adhesin-receptor interaction exists, specific chlamydial surface molecules have not been identified. We are investigating potential adhesin molecules using an in vitro functional assay to select for chlamydial recombinant Escherichia coli expressing an adherent phenotype. We have previously shown that E. coli JM109(pPBW58) attaches to epithelial cells by a specific process paralleling C. trachomatis and expresses at least three plasmid-encoded proteins (18, 28, and 82 kDa; Schmiel, D. H., Knight, B. T., Raulston, J. E., Choong, J., Davis, C. H., and Wyrick, P. B. (1991) Infect. Immun. 59, 4001-4012).One route by which Chlamydia trachomatis is internalized into host endometrial epithelial cells is receptor-mediated endocytosis. Although this implies an adhesin-receptor interaction exists, specific chlamydial surface molecules have not been identified. We are investigating potential adhesin molecules using an in vitro functional assay to select for chlamydial recombinant Escherichia coli expressing an adherent phenotype. We have previously shown that E. coli JM109(pPBW58) attaches to epithelial cells by a specific process paralleling C. trachomatis and expresses at least three plasmid-encoded proteins (18, 28, and 82 kDa; Schmiel, D. H., Knight, B. T., Raulston, J. E., Choong, J., Davis, C. H., and Wyrick, P. B. (1991) Infect. Immun. 59, 4001-4012).
A Particle Module for the PLUTO code: II - Hybrid Framework for Modeling Non-thermal emission from Relativistic Magnetized flows
Creators: name: Vaidya, Bhargav
name: Mignone, Andrea
name: Bodo, Gianluigi
name: Rossi, Paola
name: Massaglia, Silvano
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We describe a new hybrid framework to model non-thermal spectral signatures from highly energetic particles embedded in a large-scale classical or relativistic MHD flow. Our method makes use of \textit{Lagrangian} particles moving through an Eulerian grid where the (relativistic) MHD equations are solved concurrently. Lagrangian particles follow fluid streamlines and represent ensembles of (real) relativistic particles with a finite energy distribution. The spectral distribution of each particle is updated in time by solving the relativistic cosmic ray transport equation based on local fluid conditions. This enables us to account for a number of physical processes, such as adiabatic expansion, synchrotron and inverse Compton emission. An accurate semi-analytically numerical scheme that combines the method of characteristics with a Lagrangian discretization in the energy coordinate is described. In presence of (relativistic) magnetized shocks, a novel approach to consistently model particle energization due to diffusive shock acceleration has been presented. Our approach relies on a refined shock-detection algorithm and updates the particle energy distribution based on the shock compression ratio, magnetic field orientation and amount of (parameterized) turbulence. The evolved distribution from each \textit{Lagrangian} particle is further used to produce observational signatures like emission maps and polarization signals accounting for proper relativistic corrections. We further demonstrate the validity of this hybrid framework using standard numerical benchmarks and evaluate the applicability of such a tool to study high energy emission from extra-galactic jets.
description: 23 pages, 14 figures, Accepted for publication in The Astrophysical Journal
Weak magnetism in chiral quark models
Creators: name: Ohlsson, Tommy
name: Snellman, Hakan
Publisher: name: arXiv
Year: 1999
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We discuss symmetry breaking in the weak magnetism form factors for the semileptonic octet baryon decays. In the chiral quark model, the symmetry breaking can be accounted for in the masses and the quark spin polarizations can take on more general values due to Goldstone boson depolarization. Here we clarify some features of the chiral quark model prediction for the weak magnetism and compare to the corresponding result of the chiral quark soliton model.
description: 6 pages, EPJ LaTeX
Mutational analysis of active site residues of human adenosine deaminase
Creators: name: COLEMAN, M.
name: BHAUMIK, D
name: MEDIN, J
name: GATHY, K
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Adenosine deaminase was overexpressed in a baculovirus system. The pure recombinant and native enzymes were identical in size, Zn2+ content, and activity. Five amino acids, in proximity to the active site, were replaced by mutagenesis. The altered enzymes were purified to homogeneity and compared to wild-type adenosine deaminase with respect to zinc content, enzymatic activity, and kinetic parameters. All but one of the alterations produced significant activity perturbations. Replacement of Cys262 produced a protein that retained at least 30-40% of wild-type activity. In contrast, replacements of His17, His214, His238, and Glu217 resulted in dramatic losses of enzyme activity. None of these mutants exhibited large variations in Km. The proteins produced from alterations of amino acids implicated in metal coordination were slightly activated by inclusion of Zn2+ throughout purification. These experiments confirm that in the active enzyme Zn2+ plays a critical role in catalysis, that a histidine or glutamate residue plays a mechanistic role in the hydrolytic deamination step, and that cysteine is not involved in the catalytic mechanism of adenosine deaminase. These data support the roles for these amino acid residues suggested from the x-ray structure of murine adenosine deaminase (Wilson, D. K., Rudolf, F. B., and Quicho, F. A. (1991) Science 252, 1278-1284).
Renormalization group approach to Fermi Liquid Theory
Creators: name: Dupuis, N.
name: Chitov, G.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: We show that the renormalization group (RG) approach to interacting fermions at one-loop order recovers Fermi liquid theory results when the forward scattering zero sound (ZS) and exchange (ZS$'$) channels are both taken into account. The Landau parameters are related to the fixed point value of the ``unphysical'' limit of the forward scattering vertex. We specify the conditions under which the results obtained at one-loop order hold at all order in a loop expansion. We also emphasize the similarities between our RG approach and the diagrammatic derivation of Fermi liquid theory.
description: 4 pages (RevTex) + 1 postcript file, everything in a uuencoded file, uses epsf (problem with the figure in the first version)
Penicillin-binding protein 1B from Escherichia coli contains a membrane association site in addition to its transmembrane anchor
Creators: name: SCHULTZ, D.
name: LAMSON, D.
name: NICHOLAS, R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: A working structural model of penicillin-binding protein 1B (PBP 1B) from Escherichia coli derived from previous data consists of a highly charged amino-terminal cytoplasmic tail, a 23-amino-acid hydrophobic transmembrane anchor, and a 758-amino-acid periplasmic domain. Using an engineered thrombin cleavage site, we have investigated the solubility properties of the periplasmic domain of PBP 1B. Twelve amino acids, comprised of the consensus thrombin cleavage site (LVPR↓GS) and flanking glycine residues, were inserted into PBP 1B just past its putative transmembrane segment. To aid in purification, a hexahistidine tag was also inserted at its amino terminus, and the engineered protein (PBP 1B-GT/H6) was purified and characterized.A working structural model of penicillin-binding protein 1B (PBP 1B) from Escherichia coli derived from previous data consists of a highly charged amino-terminal cytoplasmic tail, a 23-amino-acid hydrophobic transmembrane anchor, and a 758-amino-acid periplasmic domain. Using an engineered thrombin cleavage site, we have investigated the solubility properties of the periplasmic domain of PBP 1B. Twelve amino acids, comprised of the consensus thrombin cleavage site (LVPR↓GS) and flanking glycine residues, were inserted into PBP 1B just past its putative transmembrane segment. To aid in purification, a hexahistidine tag was also inserted at its amino terminus, and the engineered protein (PBP 1B-GT/H6) was purified and characterized.
Purification and characterization of a DNA helicase from Saccharomyces cerevisiae
Creators: name: MATSON, S.
name: BEAN, D.
name: KALLAM, W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: A novel DNA helicase, scHelI, has been purified from whole cell extracts of Saccharomyces cerevisiae using biochemical assays to monitor the fractionation. The enzyme unwinds partial duplex DNA substrates, as long as 343 base pairs in length, in a reaction that is dependent on either ATP or dATP hydrolysis. scHelI also catalyzes a single-stranded DNA-dependent ATP hydrolysis reaction; the apparent Km for ATP is 325 microM. The unwinding reaction on circular partial duplex substrates is biphasic, with a fast component occurring within 5 min of the initiation of the reaction and a slow component continuing to 60 min. This is in contrast to the ATP hydrolysis reaction, which exhibits linear kinetics for 60 min. The direction of the unwinding reaction is 5' to 3' with respect to the strand of DNA on which the enzyme is bound. The unwinding reaction is strongly stimulated by the addition of Escherichia coli single-stranded DNA-binding protein when long partial duplex substrates are used. The enzymatic activity of scHelI copurifies with a polypeptide of 135 kDa as determined by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. The polypeptide sediments as a monomer in a glycerol gradient in the presence of 0.2 M NaCl.
Noncompact chiral U(1) gauge theories on the lattice
Creators: name: Neuberger, Herbert
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A new, adiabatic phase choice is adopted for the overlap in the case of an infinite volume, noncompact abelian chiral gauge theory. This gauge choice obeys the same symmetries as the Brillouin-Wigner (BW) phase choice, and, in addition, produces a Wess-Zumino functional that is linear in the gauge variables on the lattice. As a result, there are no gauge violations on the trivial orbit in all theories, consistent and covariant anomalies are simply related and Berry's curvature now appears as a Schwinger term. The adiabatic phase choice can be further improved to produce a perfect phase choice, with a lattice Wess-Zumino functional that is just as simple as the one in continuum. When perturbative anomalies cancel, gauge invariance in the fermionic sector is fully restored. The lattice effective action describing an anomalous abelian gauge theory has an explicit form, close to one analyzed in the past in a perturbative continuum framework.
description: 35 pages, one figure, plain TeX; minor typos corrected; to appear in PRD
Magnetic structure of the promising candidate for three-dimensional artificial spin ice: small angle neutron diffraction and micromagnetic simulations
Creators: name: Mistonov, A. A.
name: Dubitskiy, I. S.
name: Shishkin, I. S.
name: Grigoryeva, N. A.
name: Heinemann, A.
name: Sapoletova, N. A.
name: Valkovskiy, G. A.
name: Grigoriev, S. V.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Geometrical frustration arised in spin ices leads to fascinating emergent physical properties. Nowadays there is a wide diversity of the artificial structures, mimicking spin ice at the nanoscale and demonstrating some new effects. Most of the nanoscaled spin ices are two dimensional. Ferromagnetic inverse opal-like structures (IOLS) are among inspiring examples of the three-dimensional system exhibiting spin ice behaviour. However detailed examination of its properties is not straightforward. Experimental technique which is able to unambiguously recover magnetization distribution in 3D mesoscaled structures is lacking. In this work we used an approach based on complementary exploiting of small-angle neutron diffraction technique and micromagnetic simulations. External magnetic field was applied along three main directions of the IOLS mesostructure. Comparison of the calculated and measured data allowed us to determine IOLS magnetic state. The results are in good agreement with the spin ice model. Moreover influence of the demagnetizing field and vortex states on the magnetizing process were revealed. Additionally, we speculate that this approach can be also applied to other 3D magnetic mesostructures.
description: 13 pages, 9 figures
Random mutagenesis of the sheep Na, K-ATPase alpha-1 subunit generates a novel T797N mutation that results in a ouabain-resistant enzyme.
Creators: name: Price, Elmer
name: Burns, Edina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Site-directed mutagenesis of the Na,K-ATPase has provided a rational approach to identify several amino acids that appear to be involved in ouabain sensitivity. In order to identify additional amino acids that play a role in ouabain binding, we used formic acid to randomly mutagenize a cDNA cassette encoding amino acids 691-946 of the sheep Na,K-ATPase alpha subunit. This was then used to replace the wild type cDNA cassette in the full-length cDNA, and pools of mutants were electroporated into HeLa cells. Ouabain-resistant cells were selected in 0.5 microM ouabain, and the polymerase chain reaction was used to amplify the region corresponding to the mutagenized cassette from the genomic DNA of the resistant cells. Sequence analysis of the polymerase chain reaction product revealed a single amino acid substitution, T797N. Site-directed mutagenesis was used to reproduce this change in the wild type sheep alpha subunit, and this construct was able to confer resistance to HeLa cells, verifying the role of the mutation in ouabain resistance. The mutant sheep enzyme was found to be as resistant to ouabain as is the rat Na,K-ATPase. These data suggest that T797N, predicted to be in the fifth putative transmembrane domain, is involved in the interaction between ouabain and the Na,K-ATPase.
Scalar correlations in a quark plasma and low mass dilepton production
Creators: name: Blaschke, D.
name: Kalinovsky, Yu. L.
name: Schmidt, S.
name: Schulze, H. -J.
Publisher: name: arXiv
Year: 1997
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We investigate possible consequences of resonant scalar interactions for dilepton production from a quark plasma at the chiral phase transition. It is found that this production mechanism is strongly suppressed compared to the Born process and has no significance for present experiments.
description: 7 pages revtex, 2 ps figures
title: Robust Reconstruction of Historical Climate Change From Permafrost Boreholes
Creators: name: Groenke, Brian
name: Langer, Moritz
name: Miesner, Frederieke
name: Westermann, Sebastian
name: Gallego, Guillermo
name: Boike, Julia
Publisher: name: Humboldt-Universität zu Berlin
Year: 2024
Subjects: subject: borehole
subject: climate reconstruction
subject: inversion
subject: bayesian
subject: permafrost
subject: numerical modeling
subject: 550 Geowissenschaften

description: Reconstructing historical climate change from deep ground temperature measurements in cold regions is often complicated by the presence of permafrost. Existing methods are typically unable to account for latent heat effects due to the freezing and thawing of the active layer. In this work, we propose a novel method for reconstructing historical ground surface temperature (GST) from borehole temperature measurements that accounts for seasonal thawing and refreezing of the active layer. Our method couples a recently developed fast numerical modeling scheme for two-phase heat transport in permafrost soils with an ensemble-based method for approximate Bayesian inference. We evaluate our method on two synthetic test cases covering both cold and warm permafrost conditions as well as using real data from a 100 m deep borehole on Sardakh Island in northeastern Siberia. Our analysis of the Sardakh Island borehole data confirms previous findings that GST in the region have likely risen by 5–9°C between the pre-industrial period of 1750–1855 and 2012. We also show that latent heat effects due to seasonal freeze-thaw have a substantial impact on the resulting reconstructed surface temperatures. We find that neglecting the thermal dynamics of the active layer can result in biases of roughly −1°C in cold conditions (i.e., mean annual ground temperature below −5°C) and as much as −2.6°C in warmer conditions where substantial active layer thickening (>200 cm) has occurred. Our results highlight the importance of considering seasonal freeze-thaw in GST reconstructions from permafrost boreholes.
Pheidole impressa Mayr
Creators: name: Wilson, E. O.
Publisher: name: Harvard University Press
Year: 2003
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole impressa

description: Pheidole impressa Mayr
Pheidole impressa Mayr 1870b: 985. Not seen, and status unknown: Pheidole impressa var. detrita Emery 1890b: 66 (type locality: San Esteban, Venezuela).
Types Naturhist. Mus. Wien.
Etymology L impressa, marked by impression, possibly referring to the gastral striae.
diagnosis A very distinct member of the fallax group, easily distinguished as follows.
Major: anterior third of central strip of first gastral tergite longitudinally striate; the whole gastral tergite shagreened; rugoreticulum on each side of head stretches from eye medially to antennal fossa and anteriorly to near the anterior border of head; propodeal spines moderately long and nearly vertical to basal propodeal face; promesonotal dorsum transversely carinulate; all of cephalic dorsum, mesosoma, and waist foveolate and feebly shiny to opaque; postpetiolar node from above trapezoidal. Minor not seen.
Measurements (mm) Holotype major: HW 1.36, HL 1.68, SL 0.92, EL 0.22, PW 0.70.
Color Major: body and mandibles medium reddish brown, other appendages light reddish brown.
Range Known from Ceara and the neighboring state of Rio Grande do Norte, in northeastern Brazil (Kempf 1972b).
Biology Unknown.
Figure Unique holotype, major. BRAZIL: Ceara (M. E. Simon). Minor not seen. Scale bar = 1 mm.
description: Published as part of Wilson, E. O., 2003, Pheidole in the New World. A dominant, hyperdiverse ant genus., Cambridge, MA :Harvard University Press on page 303
Patterns and recent trends in mastectomy and breast conserving surgery for women with early-stage breast tumors in Missouri: An update and further investigation
Creators: name: Schmaltz, Chester Lee
name: Jackson-Thompson, Jeannette
name: Du, Jiang
name: Francis, Bec
Publisher: name: Zenodo
Year: 2018

description: Poster presented at 2018 Annual Conference of the North American Association of Central Cancer Registries, Pittsburgh, PA. June, 2018. Background: Most females age 18–64 diagnosed with an early-stage breast tumor in Missouri, 2008–2015, were surgically treated with either total (simple) mastectomy (TM), modified radical mastectomy (MRM), or breast conserving surgery (BCS). Last year, the Missouri Cancer Registry examined demographic differences between females receiving these treatments and noted a slight decrease in the % of cases getting BCS since 2008 with an increase in TM (& TM+MRM).  Discussion: These data provide quantitative population-based data on the surgical treatment for females diagnosed with early-stage breast tumors in Missouri. Trends and sociodemographic patterns may help inform patients & health professionals in Missouri by providing broad information on treatment options being utilized.
Cosmological Expansion in the Presence of an Extra Dimension
Creators: name: Cline, James M.
name: Grojean, Christophe
name: Servant, Geraldine
Publisher: name: arXiv
Year: 1999
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: It has recently been pointed out that global solutions of Einstein's equations for a 3-brane universe embedded in 4 spatial dimensions give rise to a Friedmann equation of the form H ~ rho on the brane, instead of the usual H ~ (rho)^{1/2}, which is inconsistent with cosmological observations. We remedy this problem by adding cosmological constants to the brane and the bulk, as in the recent scenario of Randall and Sundrum. Our observation allows for normal expansion during nucleosynthesis, but faster than normal expansion in the very early universe, which could be helpful for electroweak baryogenesis, for example.
description: 4pp, latex, 1 figure; added and corrected references; revised incorrect argument about sign of action on brane; final version to be published in PRL
Homology modelling, molecular docking studies and synthesis of aminopyrimidines as inhibitors for deoxynucleoside kinase analogues in cancer chemoprevention
Creators: name: James, Jainey P.
name: M., Mariyam Jouhara B.
name: Priya, Sneh
name: Jyothi, Divya
name: Vasudevan, Rajalakshimi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: The development of alternative anticancer agents with minimal side effects has become more critical due to the rising recurrence of mammalian malignancies and the severe side effects of chemotherapeutic treatments. Kinases are an essential target for neostatic impact as they play an important role in the modulation of growth factor signalling. Our work aims to screen novel nine-series of thiazole-based aminopyrimidines and sulphaminopyrimidines against the enzymes mitochondrial thymidine kinase 2, deoxyguanosine kinase (2OCP), deoxycytidine kinase (2QRN) and thymidylate kinase (1E2Q) by molecular docking, synthesise and to study their in vitro inhibitory studies. The synthesised compounds were characterised by Infrared, Nuclear magnetic resonance and Mass spectroscopy. In silico studies, compound 4c stands out among the series, with a reported docking score ranging from −6 to −8 Kcal/mol against all the analogue kinases. The in vitro cytotoxicity assay against human small-cell lung carcinoma (A-549) has shown that 5c (IC50 = 53.9 µM) has an excellent cytotoxic effect over 4c (IC50= 68.68 µM). The reason might be the presence of the benzene sulphonamide group, which enhances their anticancer action. To conclude, the compounds 4c and 5c were found to be potent inhibitors of the deoxynucleoside kinases. In vivo studies must further verify these to prove their potent neostatic effect.
RecA binding to bulge- and mismatch-containing DNAs : certain single base mismatches provide strong signals for RecA binding equal to multiple base bulges
Creators: name: Bortner, Carl D
name: Wang, Yuh-Hwa
name: Griffith, Jack
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Studies from several laboratories have demonstrated that RecA protein can recognize a variety of pertubations in the DNA helix. Here, using a nitrocellulose filter binding assay, it was observed that RecA bound to bulge-containing DNAs more effectively than non-bulged DNA. The degree of binding of RecA protein to bulged DNA was dependent on the conformation of the bulged bases and the kinking angles produced by the bulges as determined by the type and number of bases in the bulge. Although a single base mismatch does not kink DNA, RecA protein showed preferential binding to DNAs containing certain single base mismatches.Studies from several laboratories have demonstrated that RecA protein can recognize a variety of pertubations in the DNA helix. Here, using a nitrocellulose filter binding assay, it was observed that RecA bound to bulge-containing DNAs more effectively than non-bulged DNA. The degree of binding of RecA protein to bulged DNA was dependent on the conformation of the bulged bases and the kinking angles produced by the bulges as determined by the type and number of bases in the bulge. Although a single base mismatch does not kink DNA, RecA protein showed preferential binding to DNAs containing certain single base mismatches.
Discovery of the Luminous, Decades-Long, Extragalactic Radio Transient FIRST J141918.9+394036
Creators: name: Law, C. J.
name: Gaensler, B. M.
name: Metzger, B. D.
name: Ofek, E. O.
name: Sironi, L.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present the discovery of a slowly-evolving, extragalactic radio transient, FIRST J141918.9+394036, identified by comparing a catalog of radio sources in nearby galaxies against new observations from the Very Large Array Sky Survey. Analysis of other archival data shows that FIRST J141918.9+394036 faded by a factor of ~50 over 23 years, from a flux of ~26 mJy at 1.4 GHz in 1993 to an upper limit of 0.4 mJy at 3 GHz in 2017. FIRST J141918.9+394036 is likely associated with the small star-forming galaxy SDSS J141918.81+394035.8 at a redshift z=0.01957 (d=87 Mpc), which implies a peak luminosity $νL_ν\gtrsim 3\times10^{38}$ erg s$^{-1}$. If interpreted as an isotropic synchrotron blast wave, the source requires an explosion of kinetic energy ~10^{51} erg some time prior to our first detection in late 1993. This explosion could plausibly be associated with a long gamma-ray burst (GRB) or the merger of two neutron stars. Alternatively, FIRST J141918.9+394036 could be the nebula of a newly-born magnetar. The radio discovery of any of these phenomena would be unprecedented. Joint consideration of the event light curve, host galaxy, lack of a counterpart gamma-ray burst, and volumetric rate suggests that FIRST J141918.9+394036 is the afterglow of an off-axis (`orphan') long GRB. The long time baseline of this event offers the best available constraint in afterglow evolution as the bulk of shock-accelerated electrons become non-relativistic. The proximity, age, and precise localization of FIRST J141918.9+394036 make it a key object for understanding the aftermath of rare classes of stellar explosion.
description: Submitted to AAS Journals (14 pages, 3 figures)