title: ÐÐ·ÑÑÐµÐ½Ð¸Ðµ ÑÐµÐ°ÐºÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾ÑÑÐ¸ Ð»Ð°ÐºÑÐ¾Ð½Ð¾Ð², Ð²ÑÐ´ÐµÐ»ÐµÐ½Ð½ÑÑ Ð¸Ð· ÐºÑÐ»ÑÑÑÑÑ Ð¿ÑÐ¾Ð´ÑÑÐµÐ½ÑÐ° Stagonospora cirsii, Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¸Ñ Ð¿Ð¾Ð»ÑÑÐ¸Ð½ÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð½ÑÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Study of the reactivity of lactones isolated from the culture of the producer stagonospora cirsii, and the study of the biological activity of their semi-synthetic derivatives
Creators: name: ÐÑÐµÑÐ¾Ð², ÐÐ°Ð½Ð¸Ð¸Ð»
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: Ð²ÑÐ¾ÑÐ¸ÑÐ½ÑÐ¹ Ð¼ÐµÑÐ°Ð±Ð¾Ð»Ð¸Ð·Ð¼
Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ
ÑÐ¾Ð½ÐºÐ¸Ð¹ Ð¾ÑÐ³Ð°Ð½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ¸Ð½ÑÐµÐ·
Ð·Ð°ÑÐ¸ÑÐ° ÑÐ°ÑÑÐµÐ½Ð¸Ð¹
secondary metabolism
biological activity
fine organic synthesis
plant protection

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description: This work is devoted to the study of the biological activity of new 10-membered lactones obtained by modifying them by hydroxyl groups and double bonds. Tasks that were solved during the research: Â  1. Isolate 10-membered lactones from natural raw materials, synthesize new derivatives containing acyl groups and an epoxy cycle by chemical modification 2. Examine the available set of substances for biological activity 3. Carry out a comparative analysis of the biological activity profiles of the initial compounds and their derivatives. The work was carried out based on the laboratory of phytotoxicology and biotechnology of the Federal State Budgetary Scientific Institution VIZR, where a significant part of the factual material was collected. Based on the biosynthesis products of a phytopathogenic fungus, 10-membered lactones, methods for obtaining new compounds have been developed. Using a wide range of biotests for the available starting compounds and products of their chemical modification, the profiles of their biological activity were collected and analyzed. A number of compounds have shown selective biological activity. When performing a literature review, the following bases were used data: eLIBRARY.RU, Elsevier. Statistical processing of experimental data was carried out with software package: Topspin, ACD labs, Mercury, Avogadro.