cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Improving Occupants' Satisfaction with Effective Maintenance Management of HVAC System in Office Buildings
Creators: name: Au-Yong, Cheong Peng
Publisher: name: figshare
Year: 2017
Subjects: subject: 120201 Building Construction Management and Project Planning
subject: FOS: Civil engineering
subject: 120202 Building Science and Techniques
subject: 120299 Building not elsewhere classified
subject: 120503 Housing Markets, Development, Management
subject: FOS: Social and economic geography
subject: 90599 Civil Engineering not elsewhere classified
subject: 90502 Construction Engineering
subject: 90505 Infrastructure Engineering and Asset Management

description: Office buildings are equipped with HVAC system to provide a comfortable working environment. However, the level of the occupants' productivity and comfort is highly influenced by the reliability of HVAC system's service. Thus, the proper maintenance of HVAC system is necessary to ensure the smooth operations of an organisation. This paper seeks to investigate the maintenance characteristics of HVAC system that affect occupants' satisfaction and subsequently establish a relationship between the characteristics and occupants' satisfaction through questionnaire surveys and interviews; and finally develop a regression model for prediction purpose. The findings reveal that the maintenance characteristics which influence occupants' satisfaction include the skill and knowledge of the manager, the skill and knowledge of the labourer, the quality of spare parts and materials, as well as the response level towards failure and downtime. The study concludes that an effective communication platform which involves all key participants in the maintenance activities should be developed by the management to improve the maintenance outcomes.
Data and scripts necessary to perform analyses published in Zannini et al. 2022 "Investigating Sacred Natural Sites and Protected Areas for forest area changes in Italy"
Creators: name: Zannini, Piero
Publisher: name: Zenodo
Year: 2022

description: Data and scripts necessary to perform analyses published in Zannini et al. 2022 "Investigating Sacred Natural Sites and Protected Areas for forest area changes in Italy"
Soluble expression and purification of heparinase I in Escherichia coli using a hexahistidine-tagged small ubiquitin-like modifier as a fusion partner
Creators: name: Yang, Bao-Cheng
name: Zhang, Chuan
name: Wang, Chang
name: Zhou, Hao
name: Li, Zhong-Yuan
name: Ya-Jian Song
name: Tong-Cun Zhang
name: Luo, Xue-Gang
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: Heparinase has an important application in the preparation of low-molecular-weight heparins and the deheparinization of heparin-treated blood. To increase the soluble expression of heparinase I (HepI) in recombinant Escherichia coli, the hepA gene (coding for HepI) from Flavobacterium heparinum was obtained through chemical synthesis and fused with the gene encoding hexahistidine, small ubiquitin-like modifier (SUMO), a flexible peptide linker (G4S) and a bovine enterokinase site (D4K). The constructed fusion protein (SUMO–HepI) was expressed in E. coli BL21 (DE3), and then purified with Ni2+-chelating affinity chromatography. The fermentation conditions were optimized and the enzymatic properties were also analyzed. As the results showed, the recombinant SUMO–HepI was successfully expressed in E. coli BL21 (DE3) and purified with affinity chromatography. The recombinant protein reached the highest soluble expression when the expression strain was induced by 0.6 mmol/L isopropyl β-D-thiogalactoside and grown at 30 °C with a shaking speed of 150 r/min for 9 h. The fusion protein could exhibit high enzyme activity without requirements of in vitro refolding and SUMO-tag releasing process, and the optimum enzyme activity was obtained at 30 °C, pH 7.0 and 10 mmol/L Ca2+ in the reaction buffer. This work provided a novel simple approach for the soluble expression of HepI in E. coli, and might establish a foundation for the following production and application of HepI in the industry.
The effectiveness of aided augmented input techniques for persons with developmental disabilities: a systematic review
Creators: name: Allen, Anna A.
name: Schlosser, Ralf W.
name: Brock, Kristofer L.
name: Shane, Howard C.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: When working with individuals with little or no functional speech, clinicians often recommend that communication partners use the client’s augmentative and alternative communication (AAC) device when speaking to the client. This is broadly known as “augmented input” and is thought to enhance the client’s learning of language form and content. The purpose of this systematic review was to determine the effects of augmented input on communication outcomes in persons with developmental disabilities and persons with childhood apraxia of speech who use aided AAC. Nineteen studies met the inclusion criteria. Each included study was reviewed in terms of participant characteristics, terminology used, symbol format, augmented input characteristics, outcomes measured, effectiveness, and study quality. Results indicate that augmented input can improve single-word vocabulary skills and expression of multi-symbol utterances; however, comprehension beyond the single word level has not been explored. Additionally, it is difficult to form conclusions about the effect of augmented input on specific diagnostic populations. Directions for future research are posited.
Soluble expression and purification of heparinase I in Escherichia coli using a hexahistidine-tagged small ubiquitin-like modifier as a fusion partner
Creators: name: Yang, Bao-Cheng
name: Zhang, Chuan
name: Wang, Chang
name: Zhou, Hao
name: Li, Zhong-Yuan
name: Ya-Jian Song
name: Tong-Cun Zhang
name: Luo, Xue-Gang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: Heparinase has an important application in the preparation of low-molecular-weight heparins and the deheparinization of heparin-treated blood. To increase the soluble expression of heparinase I (HepI) in recombinant Escherichia coli, the hepA gene (coding for HepI) from Flavobacterium heparinum was obtained through chemical synthesis and fused with the gene encoding hexahistidine, small ubiquitin-like modifier (SUMO), a flexible peptide linker (G4S) and a bovine enterokinase site (D4K). The constructed fusion protein (SUMO–HepI) was expressed in E. coli BL21 (DE3), and then purified with Ni2+-chelating affinity chromatography. The fermentation conditions were optimized and the enzymatic properties were also analyzed. As the results showed, the recombinant SUMO–HepI was successfully expressed in E. coli BL21 (DE3) and purified with affinity chromatography. The recombinant protein reached the highest soluble expression when the expression strain was induced by 0.6 mmol/L isopropyl β-D-thiogalactoside and grown at 30 °C with a shaking speed of 150 r/min for 9 h. The fusion protein could exhibit high enzyme activity without requirements of in vitro refolding and SUMO-tag releasing process, and the optimum enzyme activity was obtained at 30 °C, pH 7.0 and 10 mmol/L Ca2+ in the reaction buffer. This work provided a novel simple approach for the soluble expression of HepI in E. coli, and might establish a foundation for the following production and application of HepI in the industry.
Significant Characteristics of Scheduled and Condition-Based Maintenance in Office Buildings
Creators: name: Au-Yong, Cheong Peng
Publisher: name: figshare
Year: 2017
Subjects: subject: 120201 Building Construction Management and Project Planning
subject: FOS: Civil engineering
subject: 120202 Building Science and Techniques
subject: 120299 Building not elsewhere classified
subject: 120503 Housing Markets, Development, Management
subject: FOS: Social and economic geography
subject: 90599 Civil Engineering not elsewhere classified
subject: 90502 Construction Engineering

description: Sustainability of buildings is one of the main aims in the construction industry. In achieving sustainability, maintenance of buildings and its facilities, which include planning, implementation, and outcome of maintenance activities, becomes an important criterion. This paper aims to identify the significant characteristics of scheduled and condition-based maintenance in office buildings through reviews of relevant literature and a questionnaire survey. The significance of the characteristics was identified through ranking analysis. A semistructured interview was conducted to obtain further details on the characteristics and measures to enhance efficiency of the characteristics. The findings reveal that the dominant characteristics for scheduled maintenance include quality of spare part and material, the level of labor skill and knowledge, and budget allocation for maintenance labor, whereas for condition-based maintenance, the dominant characteristics are the level of manager skill and knowledge, reliability of maintenance data, and financial allocation for the maintenance manager. The study concludes that these dominant characteristics should be considered in the implementation of maintenance strategies.
An elementary algorithm to evaluate trigonometric functions to high precision
Creators: name: B. Tomas Johansson
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Evaluation of the cosine function is done via a simple Cordic-like algorithm, together with a package for handling arbitrary-precision arithmetic in the computer program Matlab. Approximations to the cosine function having hundreds of correct decimals are presented with a discussion around errors and implementation.
An intertropical opossum (Mammalia, Marsupialia, Didelphidae) from the late Middle–Late Pleistocene of austral South America
Creators: name: Vezzosi, Raúl Ignacio
name: Brunetto, Ernesto
name: Flores, David
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: The record of an opossum is reported here coming from a Middle–Late Pleistocene fluvial sedimentary sequence outcropping in the austral Chaco geomorphological region, Santa Fe province. Despite this family has different living forms widely distributed in South American plains, with great tolerance to diverse habitats conditions, the Pleistocene occurrence of didelphoids is very scarce and only limited to Holocene deposits sensu lato from austral pampean plains. The specimen found represents at the moment the only Pleistocene didelphoid opossum from Argentina with an accurate stratigraphical context. In a taphonomic framework, MFA-Pv 1582 shows no evidence of abrasion produced by transport, probably resulting of a very short time-transport. This intertropical form of Didelphis genus from Pleistocene sequences displays undoubtedly novel and sustancial paleoenvironmental and ecomorphological conditions to test in the austral Chaco region. Although the specimen shares a generalized didelphoid form, some morphologies in the humerus are closer with arboreal habits. In this context, added to the sedimentological and stratigraphical framework, it’s possible to suggest that subtropical conditions with some woodlands and wetlands dominate the provenance region of the fossil material, over a late Middle–Late Pleistocene interglacial period.
Optimising Maintenance Cost Performance with Skilled Technicians
Creators: name: Au-Yong, Cheong Peng
Publisher: name: figshare
Year: 2017
Subjects: subject: 120201 Building Construction Management and Project Planning
subject: FOS: Civil engineering
subject: 120202 Building Science and Techniques
subject: 120299 Building not elsewhere classified
subject: 120503 Housing Markets, Development, Management
subject: FOS: Social and economic geography
subject: 90599 Civil Engineering not elsewhere classified
subject: 90502 Construction Engineering
subject: 90505 Infrastructure Engineering and Asset Management

description: Purpose – High-maintenance cost is the common issue in building industry due to low service quality of maintenance management in Malaysia. Lack of preventive measure is the problem that implicates poor maintenance performance. Scheduled maintenance is suggested to improve the maintenance performance. However, the effectiveness of scheduled maintenance can be greatly influenced by the availability of skilled technicians. Thus, the purpose of this paper is to identify the aspects of skilled technician to be concerned in maintenance management, as well as to establish the relationship between the aspects and maintenance cost performance.
Design/methodology/approach – A quantitative approach is adopted and carried out through questionnaire survey. Furthermore, descriptive analysis and correlation analysis are used to analyse the research data.
Findings – The literature review identifies three aspects of skilled technician to be concerned in maintenance management. Then, research result demonstrates that the skill and knowledge of technician is significantly correlated to the maintenance cost variance. The skill and knowledge of technician must be considered in maintenance planning and execution.
Originality/value – The research recommends the maintenance management to employ skilled technician through thorough hiring process and to encourage the existing maintenance staff for participating the relevant training, workshop, or seminar.
Heterostructured titanium composites with superior strength-ductility synergy via controllable bimodal grains and dislocation activity
Creators: name: Chen, Jiajing
name: Han, Yuanfei
name: Wei, Zichao
name: Li, Shaopeng
name: Sun, Zhonggang
name: Zhang, Liang
name: Huang, Guangfa
name: Le, Jianwen
name: Zhang, Di
name: Lu, Weijie
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Computational Biology

description: Constructing heterostructures in particulate reinforced titanium matrix composites (PRTMCs) to evade the strength-ductility trade-off dilemma is much more difficult than in metals. Here, we proposed a novel and controllable strategy of simple powder assembly to fabricate bimodal-grained PRTMCs, this customized strategy makes coarse grains (CGs) surrounded by ultrafine-grained (UFG) matrices, conferring a superior strength-ductility combination not achievable by their traditional homogeneous counterparts. We found that such heterostructures appear to promote storage of mostly dislocations in CGs and accumulation near the CG/UFG boundaries. Moreover, hybrid reinforcements also activate multiple hardening mechanisms, inducing high ductility. We proposed a novel and controllable strategy of simple powder assembly to fabricate heterostructured metal matrix composites for breaking the strength-ductility trade-off dilemma and revealed the enhanced dislocation activity.
New draft itemSignificant Characteristics of Scheduled and Condition-Based Maintenance in Office Buildings
Creators: name: Au-Yong, Cheong Peng
Publisher: name: figshare
Year: 2017
Subjects: subject: 120201 Building Construction Management and Project Planning
subject: FOS: Civil engineering
subject: 120202 Building Science and Techniques
subject: 120299 Building not elsewhere classified
subject: 120503 Housing Markets, Development, Management
subject: FOS: Social and economic geography
subject: 90599 Civil Engineering not elsewhere classified
subject: 90502 Construction Engineering

description: Sustainability of buildings is one of the main aims in the construction industry. In achieving sustainability, maintenance of buildings and its facilities, which include planning, implementation, and outcome of maintenance activities, becomes an important criterion. This paper aims to identify the significant characteristics of scheduled and condition-based maintenance in office buildings through reviews of relevant literature and a questionnaire survey. The significance of the characteristics was identified through ranking analysis. A semistructured interview was conducted to obtain further details on the characteristics and measures to enhance efficiency of the characteristics. The findings reveal that the dominant characteristics for scheduled maintenance include quality of spare part and material, the level of labor skill and knowledge, and budget allocation for maintenance labor, whereas for condition-based maintenance, the dominant characteristics are the level of manager skill and knowledge, reliability of maintenance data, and financial allocation for the maintenance manager. The study concludes that these dominant characteristics should be considered in the implementation of maintenance strategies.
Supplementary Material for: THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived Neurons
Creators: name: Obiorah, I.V.
name: Muhammad, H.
name: Stafford, K.
name: Flaherty, E.K.
name: Brennand, K.J.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Given the cognitive and behavioral effects following in utero Δ9-tetrahydrocannabinol (THC) exposure that have been reported in humans and rodents, it is critical to understand the precise consequences of THC on developing human neurons. Here, we utilize excitatory neurons derived from human-induced pluripotent stem cells (hiPSCs), and report that in vitro THC exposure reduced expression of glutamate receptor subunit genes (GRIA1, GRIA2, GRIN2A, and GRIN2B). By expanding these studies across hiPSC-derived neurons from individuals with a variety of genotypes, we believe that a hiPSC-based model will facilitate studies of the interaction of THC exposure and the genetic risk factors underlying neuropsychiatric disease vulnerability.
The relevance of hippocampal subfield integrity and clock drawing test performance for the diagnosis of Alzheimer’s disease and mild cognitive impairment
Creators: name: Dusan Hirjak
name: Sambataro, Fabio
name: Remmele, Barbara
name: Kubera, Katharina M.
name: Schröder, Johannes
name: Seidl, Ulrich
name: Thomann, Anne K.
name: Maier-Hein, Klaus H.
name: Wolf, Robert C.
name: Thomann, Philipp A.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Objectives: The clock drawing test (CDT) is one of the worldwide most used screening tests for Alzheimer’s disease (AD). MRI studies have identified temporo-parietal regions being involved in CDT impairment. However, the contributions of specific hippocampal subfields and adjacent extrahippocampal structures to CDT performance in AD and mild cognitive impairment (MCI) have not been investigated so far. It is unclear whether morphological alterations or CDT score, or a combination of both, are able to predict AD. Methods: 38 AD patients, 38 MCI individuals and 31 healthy controls underwent neuropsychological assessment and MRI at 3 Tesla. FreeSurfer 5.3 was used to perform hippocampal parcellation. We used a collection of statistical methods to better understand the relationship between CDT and hippocampal formation. We also tested the clinical feasibility of this relationship when predicting AD. Results: Impaired CDT performance in AD was associated with widespread atrophy of the cornu ammonis, presubiculum, and subiculum, whereas MCI subjects showed CDT-related alterations of the CA4-dentate gyrus and subiculum. CDT correlates in AD and MCI showed regional and quantitative overlap. Importantly, CDT score was the best predictor of AD. Conclusions: Our findings lend support for an involvement of different hippocampal subfields in impaired CDT performance in AD and MCI. CDT seems to be more efficient than subfield imaging for predicting AD.
Near-optimal tensor methods for minimizing gradient norm
Creators: name: Dvurechensky, Pavel
name: Gasnikov, Alexander
name: Ostroukhov, Petr
name: Uribe, A. Cesar
name: Ivanova, ##!Error: Attribute  Unknown!##
Publisher: name: Weierstrass Institute
Year: 2020
Subjects: subject: Convex optimization
subject: tensor methods
subject: gradient norm
subject: nearly optimal methods
subject: 90C30
subject: 90C25
subject: 68Q25

description: Motivated by convex problems with linear constraints and, in particular, by entropy-regularized optimal transport, we consider the problem of finding approximate stationary points, i.e. points with the norm of the objective gradient less than small error, of convex functions with Lipschitz p-th order derivatives. Lower complexity bounds for this problem were recently proposed in [Grapiglia and Nesterov, arXiv:1907.07053]. However, the methods presented in the same paper do not have optimal complexity bounds. We propose two optimal up to logarithmic factors methods with complexity bounds with respect to the initial objective residual and the distance between the starting point and solution respectively
Metabolic profiles of corydaline in rats by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry
Creators: name: Chai, Liwei
name: Donkor, Paul Owusu
name: Wang, Kun
name: Sun, Yingjie
name: Oppong, Mahmood Brobbey
name: Wang, Kai
name: Ding, Liqin
name: Qiu, Feng
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: 1. Corydaline, an isoquinoline alkaloid obtained from the rhizomes of Corydalis yanhusuo, exhibits anti-acetylcholinesterase, anti-angiogenic, anti-allergic and gastric-emptying activities. In this study, a rapid and reliable ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS) method was developed and employed for the comprehensive study of the metabolites of corydaline in rats. 2. Altogether, 43 metabolites were identified in the plasma (11), bile (9), urine (34) and feces (21) of rats after oral administration of corydaline at a dose of 4.5mg/kg. 3. It was demonstrated that demethylation, hydroxylation, sulfation and glucuronidation were the major metabolic transformation pathways. Among these, two metabolites were identified as tetrahydropalmatine and isocorybulbine, and 33 phase I and phase II products were inferred to be new metabolites arising from the in vivo metabolism of corydaline. 4. Importantly, this research provides scientific and reliable support for full understanding of the metabolic profiles of corydaline and the results could help to elucidate its safety and efficacy.
The relevance of hippocampal subfield integrity and clock drawing test performance for the diagnosis of Alzheimer’s Disease and Mild Cognitive Impairment
Creators: name: Dusan Hirjak
name: Sambataro, Fabio
name: Remmele, Barbara
name: Kubera, Katharina M.
name: Schröder, Johannes
name: Seidl, Ulrich
name: Thomann, Anne K.
name: Maier-Hein, Klaus H.
name: Wolf, Robert C.
name: Thomann, Philipp A.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Objectives: The clock drawing test (CDT) is one of the worldwide most used screening tests for Alzheimer’s disease (AD). MRI studies have identified temporo-parietal regions being involved in CDT impairment. However, the contributions of the hippocampal formation to CDT performance in AD and mild cognitive impairment (MCI) have not been investigated so far. It is unclear whether morphological alterations or CDT score, or a combination of both, are able to predict AD. Methods: 38 AD patients, 38 MCI individuals and 31 healthy controls underwent neuropsychological assessment and MRI at 3 Tesla. FreeSurfer 5.3 was used to perform hippocampal parcellation. We used a collection of statistical methods to better understand the relationship between CDT and hippocampal formation. We also tested the clinical feasibility of this relationship when predicting AD. Results: Impaired CDT performance in AD was associated with widespread atrophy of the cornu ammonis, presubiculum, and subiculum, whereas MCI subjects showed CDT-related alterations of the CA4-dentate gyrus and subiculum. CDT correlates in AD and MCI showed regional and quantitative overlap. Importantly, CDT score was the best predictor of AD. Conclusions: Our findings lend support for an involvement of different hippocampal subfields in impaired CDT performance in AD and MCI. CDT seems to be more efficient than subfield imaging for predicting AD.
Beta-lactamase database (BLDB) – structure and function
Creators: name: Naas, Thierry
name: Saoussen Oueslati
name: Bonnin, Rémy A.
name: Dabos, Maria Laura
name: Zavala, Agustin
name: Dortet, Laurent
name: Retailleau, Pascal
name: Iorga, Bogdan I.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Beta-Lactamase Database (BLDB) is a comprehensive, manually curated public resource providing up-to-date structural and functional information focused on this superfamily of enzymes with a great impact on antibiotic resistance. All the enzymes reported and characterised in the literature are presented according to the class (A, B, C and D), family and subfamily to which they belong. All three-dimensional structures of β-lactamases present in the Protein Data Bank are also shown. The characterisation of representative mutants and hydrolytic profiles (kinetics) completes the picture and altogether these four elements constitute the essential foundation for a better understanding of the structure-function relationship within this enzymes family. BLDB can be queried using different protein- and nucleotide-based BLAST searches, which represents a key feature of particular importance in the context of the surveillance of the evolution of the antibiotic resistance. BLDB is available online at http://bldb.eu without any registration and supports all modern browsers.
Sex-specific reproductive trade-offs in the gregarious fucoid macroalga Ascophyllum nodosum
Creators: name: Kurr, Martyn
name: Davies, Andrew J.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: Sociology
subject: FOS: Sociology

description: The existence of sex-specific reproductive trade-offs is well established in plants. They usually occur because females invest more resources into reproduction than males, and have to compensate by sacrificing growth or defence. Investigations into by-sex differences in resource allocation by seaweeds are comparatively scarce. A small number of authors report differences between the sexes in some red algae, but known by-sex differences in brown algae are largely confined to the reproductive structures. In this study, sex-specific reproductive trade-offs are investigated in the common temperate brown alga Ascophyllum nodosum from three distinct populations. Quantified investments into growth, defence, and reproduction of a large number of individuals (n = 720) selected across a full annual cycle are presented in parallel with feeding trials using a common gastropod herbivore and a comprehensive assessment of the biotic and abiotic stressors impacting on A. nodosum at three sites. These reveal that sex-specific reproductive trade-offs occur in two of the three populations, as females invest more into reproduction than males and are subsequently less chemically defended for the months post gamete release. Feeding trials confirm that this leaves females more vulnerable to grazing pressure during these months, although mortality and competitive ability appear unaffected in the field. Possible causes of the trade-offs made by females are discussed, and new avenues of investigation are identified which could reveal interesting parallels between seaweeds and higher plants.
ISPU American Muslim Poll January 2018: General Population Sample
Creators: name: Institute For Social Policy And Understanding (ISPU)
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: Satisfaction with way things are going in country (1); President Donald Trump job approval (1); voting and voter registration (3); justification for death of civilians (2); importance of being American/your religion (2); discrimination in past year (3); importance of religion (1); attend religious services (1): visible symbol of faith (2); statements about faith and identity (9); statements about Muslim identity and terrorism (13); civil rights of Muslims (4); partner or spouse shares your religion (1); religious discrimination.
title: 01_0698
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Material Simulation settings for microstructural modelling
Creators: name: MORETTI, Marie Anna
name: DALAI, Biswajit
name: DTrunal BHUJANGRAO
name: JACQUIN, Dimitri
Publisher: name: Zenodo
Year: 2020
Subjects: Material Simulation; microstructural modelling; mechanical characterisation; microstructural analysis

description: The objective of this deliverable is to provide a list of parameters which are to be used in modelling different microstructural phenomena mentioned above. The values of these parameters could be obtained from the literature (properties of the material), mechanical characterisation (flow stress behaviour), microstructural analysis (of specimens after plastic deformation) and model calibration (results from experiments and simulations). In order to study the mechanical response of the selected materials, various experiments were scheduled to be performed at different loading conditions as listed in Table 1.1. This deliverable basically consists of two segments. The first section discusses about the microstructural background of the selected materials in terms of precipitation evolution, phase transformation and DRX. The second section is focused on the basic structure and the underlying physical mechanisms of several microstructural models already implemented by other researchers. The physical model to be developed in this research work could use the simulation settings advocated by these pre-existing models complemented with additional information from the literature and microstructural analysis of the specimens deformed during the mechanical tests. Part of this deliverable has been reproduced and extended from Deliverable 1.1 and 1.2.
Bulge oligonucleotide as an inhibitory agent of bacterial topoisomerase I
Creators: name: Yang, Zhaoqi
name: Jiang, Tuoyu
name: Zhong, Hanshi
name: Kang, Yu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Bacterial topoisomerase I (Btopo I) was defined as potential target for discovery of new antibacterial compounds. Various oligonucleotides containing bulge structure were designed and synthesised as inhibitors to Btopo I in this investigation. The results of this study demonstrated that the designed oligonucleotides display high inhibitory efficiency on the activity of Btopo I and the inhibitory effect could be modulated by the amount of bulge DNA bases. The most efficient one among them showed an IC50 value of 63.1 nM in its inhibition on the activity of Btopo I. In addition, our studies confirmed that the designed oligonucleotide would induce irreversible damages to Btopo I and without any effects occur to eukaryotic topoisomerase I. It is our hope that the results provided in these studies could provide a novel way to inhibit Btopo I.
Long form of thymic stromal lymphopoietin of keratinocytes is induced by protein allergens
Creators: name: Kuroda, Yasutaka
name: Yuki, Takuo
name: Takahashi, Yutaka
name: Sakaguchi, Hitoshi
name: Matsunaga, Kayoko
name: Itagaki, Hiroshi
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A growing body of evidence suggests that epicutaneous sensitization of protein allergens induces immediate-type hypersensitivity (IHS) following induction of Type 2 immune responses in animals and humans. Thymic stromal lymphopoietin (TSLP) derived from keratinocytes is a cytokine that can activate dendritic cells and has been implicated in development of inflammatory Type 2 helper T-cells. However, there is no direct evidence that allergens directly regulate TSLP expression in keratinocytes. This study aimed to evaluate the response of TSLP to protein allergens in cultured human keratinocytes and to identify appropriate endpoints for IHS. The transcription of long-form TSLP (loTSLP) was strongly induced by ovalbumin, wheat gluten (WG), acid-hydrolyzed WG (acid-HWG), and extracts from feces of Dermatophagoides pteronyssinus and D. farina, and trypsin, but not by rare allergens, human serum albumin (HSA), or extracts of mite bodies. In acid-HWG, loTSLP mRNA was significantly augmented by acid hydrolysis of WG for 0.5 h compared to WG. However, prolonged acid hydrolysis attenuated this induction similarly to that reported in previous animal studies. These results suggested that intense loTSLP transcriptional induction was a characteristic of a high-allergenic protein. Additionally, TSLP production was induced by exposure to ovalbumin, WG, and acid-HWG in combination with a trio of cytokines, i.e. interleukin (IL)-4, IL-13, and tumor necrosis factor (TNF)-α. However, no TSLP protein was detected following exposure to HSA, even in the presence of these cytokines. With acid-HWG, TSLP protein release was consistent with loTSLP transcription. Thus, intense loTSLP transcriptional induction and TSLP protein expression are each effective indicators that can be used for in vitro screening of IHS.
Bibliography on the Preservation of Fruits and Vegetables in Transit and Storage, With Annotations
Creators: name: Rice, Katharine G.
name: Rice, Katharine G.
Publisher: name: Unknown
Year: 1922
Subjects: subject: Crop Production/Industries
subject: Marketing
subject: FOS: Economics and business
subject: Research and Development/Tech Change/Emerging Technologies

description: In assembling this bibliography an attempt has been made to cover rather completely the publications issued prior to July 1, 1920, that have a bearing on the preservation of fruits and vegetables in transit and storage. The successful marketing of perishable products depends to a large extent on harvesting and transporting or storing them in such a way that they will reach the consumer in a satisfactory condition at the time he wants them. Special attention has been given to investigational and historical material. Bulletins and articles of a popular nature which deal with the practical application of the results of investigations and with commercial practices have also been included. It is hoped that the annotations will be useful in giving some idea of the extent and character of the material included in the references.
description: Table of contents: Cold storage; Common storage; Decays, and physiological disturbances; Dehydration; Handling; Ice house and cold storages; Packing, packages and grades; Pits and trench storage; Precooling; Prevention of freezing in transit; References with related interest; Refrigerator cars; Ripening and respiration; Standardization; Technology; Transportation
Comparison of anticancer activity of biocompatible ZnO nanoparticles prepared by solution combustion synthesis using aqueous leaf extracts of Abutilon indicum, Melia azedarach and Indigofera tinctoria as biofuels
Creators: name: G. K. Prashanth
name: P. A. Prashanth
name: B. M. Nagabhushana
name: S. Ananda
name: G. M. Krishnaiah
name: H. G. Nagendra
name: H. M. Sathyananda
name: C. Rajendra Singh
name: S. Yogisha
name: S. Anand
name: Y. Tejabhiram
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: Recently, there has been an upsurge in the use of naturally available fuels for solution combustion synthesis (SCS) of nanoparticles. Although many reports suggest that these biofuels pose less harm to the environment, their strategic advantages and reliability for making NPs has not been discussed. In the present work, we try to address this issue using plant extracts as biofuels for the SCS of zinc oxide nanoparticles as a model system. In the present work, combustion synthesis of ZnO NPs using lactose and aqueous leaf extracts of Abutilon indicum, Melia azedarach, Indigofera tinctoria as biofuels has been carried out. A comparative analysis of the obtained powders has been conducted to understand the strategic advantages of using plant extracts over a chemical as combustion fuel for the synthesis of zinc oxide nanoparticles. The X-ray diffractograms of the samples revealed the presence of Wurtzite hexagonal structure with varying crystallite sizes. Morphological studies indicated that samples prepared using biofuels had smaller diameter than those prepared using lactose as fuel. Surface characteristics of the samples were measured by X-ray photoelectron spectroscopy. Qualitative phytochemical screening of aqueous leaf extracts revealed the presence of many phytochemicals in them, which might be responsible for combustion. Gas chromatography mass spectrum was carried out to detect the phytochemicals present in the aqueous extracts of the leaves. Further, anticancer evaluation carried out against DU-145 and Calu-6 cancer cells indicated higher anticancer activity of zinc oxide nanoparticles prepared using biofuels. The results of blood haemolysis revealed the biocompatibility of zinc oxide nanoparticles at lower concentrations. In conclusion, we propose that multiple other studies would be required in order to vindicate the potential advantages of using naturally available fuels in SCS.
title: NMR Study of Spin Dynamics in V7Zn and V7Ni Molecular Rings
Creators: name: Adelnia, F.
name: Arosio, P.
name: Mariani, M.
name: Orsini, F.
name: Radaelli, A.
name: Sangregorio, C.
name: Borsa, F.
name: Walsh, J.P.S.
name: Winpenny, R.
name: Timco, G.
name: Lascialfari, A.
Publisher: name: University of Massachusetts Amherst
Year: 2020

description: We present a 1H NMR investigation of spin dynamics in to finite integer spin molecular nanomagnetic rings, namely V7Zn and V7Ni. This study could be put in correlation with the problem of Haldane gap in infinite integer spin chains. While V7Zn is an approximation of a homometallic broken chain due to the presence of s = 0 Zn2+ ion uncoupled from nearest neighbor V2+ s = 1 ions, the V7Ni compound constitutes an example of a closed periodical s = 1 heterometallic chain. From preliminary susceptibility measurements on single crystals and data analysis, the exchange coupling constant J/kB results in the order of few kelvin. At room temperature, the frequency behavior of the 1H NMR spin–lattice relaxation rate 1/T1 allowed to conclude that the spin–spin correlation function is similar to the one observed in semi-integer spin molecules, but with a smaller cutoff frequency. Thus, the high-T data can be interpreted in terms of, e.g., a Heisenberg model including spin diffusion. On the other hand, the behavior of 1/T1 vs temperature at different constant fields reveals a clear peak at temperature of the order of J/kB, qualitatively in agreement with the well-known Bloembergen–Purcell–Pound model and with previous results on semi-integer molecular spin systems. Consequently, one can suggest that for a small number N of interacting s = 1 ions (N = 8), the Haldane conjecture does not play a key role on spin dynamics, and the investigated rings still keep the quantum nature imposed mainly by the low number of magnetic centers, with no clear topological effect due to integer spins.
Martin Black Prize Presentation
Creators: name: Charlton, Peter H
name: Bonnici, Timothy
Publisher: name: Zenodo
Year: 2017
Subjects: respiratory rate
biomedical signal processing
electrocardiogram
photoplethysmogram

description: This presentation was given at the MEIbioeng / MPEC 2017 Conference on the 14th September 2017, in acceptance of the Martin Black Prize for the best paper published in Physiological Measurement in 2016. It provides an overview of the following paper: Charlton, P. H., Bonnici, T., Tarassenko, L., Clifton, D. A., Beale, R., & Watkinson, P. J. (2016). An assessment of algorithms to estimate respiratory rate from the electrocardiogram and photoplethysmogram. Physiological Measurement, 37(4), 610–26. DOI: https://doi.org/10.1088/0967-3334/37/4/610
Influence of relative wall thickness on electrocardiographic voltage measures in left ventricular hypertrophy: a novel factor contributing to poor diagnostic accuracy
Creators: name: Ye, Ning
name: Sun, Guo-Zhe
name: Zhou, Ying
name: Wu, Shao-Jun
name: Sun, Ying-Xian
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Developmental Biology
subject: Mental Health

description: Objective: To characterize the influence of relative wall thickness (RWT) on Cornell, Sokolow-Lyon and Peguero-Lo Presti voltages and elucidate its potential impacts on their diagnostic accuracy for LVH in a large general Chinese population. Methods: A total of 10,614 permanent residents aged ≥ 35 years were recruited for this study. All the participants were subjected to ECG and echocardiogram during the same visit. Multivariate linear and logistic regression analyzes were conducted to assess the influence of RWT on the voltages and their diagnostic performance for LVH detection. Results: A distinct correlation was identified between RWT and Cornell and Peguero-Lo Presti voltages following adjustments for age, gender and left ventricular mass (LVM) (β = 0.675 and 1.342, respectively; Ps < 0.001). Besides, subjects with RWT > 0.42 exhibited higher rates of LVH diagnosed by Cornell (OR = 1.78, 95% CI: 1.45–2.20), Sokolow-Lyon (OR = 1.30, 95% CI: 1.08–1.56), and Peguero-Lo Presti voltage (OR = 1.48, 95% CI: 1.29–1.70) after adjustments for age, gender and echocardiographic LVH. Furthermore, concentric remodeling or concentric hypertrophy displayed higher rates of LVH diagnoses via Cornell and Peguero-Lo Presti voltage criteria, as compared with normal geometry or eccentric hypertrophy, respectively (all Ps < 0.05), findings of which were independent of age, gender and LVMI. Conclusion: Echocardiographic RWT was independently correlated with electrocardiographic voltage measures of LVH, which influenced their positive rates and contributed to poor diagnostic performance.