cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Locations of video interviews from Engaging research with policy and action: what are the challenges of responding to zoonotic disease in Africa?
Creators: name: Bardosh, Kevin Louis
name: Scoones, Jake Cornwall
name: Grace, Delia
name: Kalema-Zikusoka, Gladys
name: Jones, Kate E.
name: Balogh, Katinka De
name: Waltner-Toews, David
name: Bett, Bernard
name: Welburn, Susan C.
name: Mumford, Elizabeth
name: Vupenyu Dzingirai
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Links to the interviews relating to this paper.
Supplementary Figures from The circadian dynamics of small nucleolar RNA in the mouse liver
Creators: name: Aitken, Stuart
name: Semple, Colin A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Biophysics
subject: 60114 Systems Biology
subject: FOS: Biological sciences

description: The circadian regulation of gene expression allows plants and animals to anticipate predictable environmental changes. While the influence of the circadian clock has recently been shown to extend to ribosome biogenesis, the dynamics and regulation of the many small nucleolar RNA that are required in pre-ribosomal RNA folding and modification are unknown. Using a novel computational method, we show that 18S and 28S pre-rRNA are subject to circadian regulation in a nuclear RNA sequencing time course. A population of snoRNA with circadian expression is identified that is functionally associated with rRNA modification. More generally, we find the abundance of snoRNA known to modify 18S and 28S to be inversely correlated with the abundance of their target. Cyclic patterns in the expression of a number of snoRNA indicate a coordination with rRNA maturation, potentially through an upregulation in their biogenesis, or their release from mature rRNA at the end of the previous cycle of rRNA maturation, in antiphase with the diurnal peak in pre-rRNA. Few cyclic snoRNA have cyclic host genes, indicating the action of regulatory mechanisms in addition to transcriptional activation of the host gene. For highly expressed independently transcribed snoRNA, we find a characteristic RNA polymerase II and H3K4me3 signature that correlates with mean snoRNA expression over the day.
A new isocoumarin from the aerial parts of Aconitum gymnandrum
Creators: name: Zhao, Jian-Qiang
name: Wang, Yan-Ming
name: Wang, Shuo
name: Dang, Jun
name: Shi, Yan-Ping
name: Mei, Li-Juan
name: Tao, Yan-Duo
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences

description: A new isocoumarin, along with 10 known compounds, was isolated from the aerial parts of Aconitum gymnandrum. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Among the known compounds, compound 11 was obtained as a natural product for the first time, which was previously reported as a synthetic product. In addition, compounds 1–5, 7 and 9 were tested for their cytotoxicity against four human cancer cell lines. The results showed that compounds 3, 4 and 7 displayed cytotoxicity against lung cancer A549 and gastric cancer MGC80, respectively, whereas 5 and 9 showed selective cytotoxicity against hepatocellular carcinoma HepG2.
Cytotoxic flavonoids from the fruits of Derris indica
Creators: name: Chalotorn Saraphon
name: Kampeebhorn Boonloh
name: Veerapol Kukongviriyapan
name: Chavi Yenjai
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Chemical investigation of the ethyl acetate extract from the fruits of Derris indica has led to the isolation of a new furanoflavonoid derivative, 4′-hydroxypinnatin (1), and five known compounds. Pinnatin (2) showed strong cytotoxicity against cholangiocarcinoma (KKU-100) and human hepatoma (HepG2) cell lines with IC50 values of 6.0 ± 2.7 and 9.0 ± 4.1 μg/ml, respectively, and showed maximal cell killing effect of about 88–90%. Flavone 5 exhibited the most cytotoxicity against KKU-100 but it showed moderate efficacy (Emax = 50.7%).
Preparation and evaluation of floating tablets of pregabalin
Creators: name: Kanwar, Navjot
name: Kumar, Rakesh
name: Sarwal, Amita
name: R. Sinha, V.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: Space Science
Pharmacology
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Floating tablets of pregabalin were prepared using different concentrations of the gums (xanthan gum and guar gum), Carbopol 974P NF and HPMC K100. Optimized formulations were studied for physical tests, floating time, swelling behavior, in vitro release studies and stability studies. In vitro drug release was higher for tablet batches containing guar and xanthan gum as compared to the batches containing Carbopol 974P NF. Tablet batches were subjected to stability studies and evaluated by different parameters (drug release, drug content, FTIR and DSC studies). The optimized tablet batch was selected for in vivo pharmacodynamic studies (PTZ induced seizures). The results obtained showed that the onset of jerks and clonus were delayed and extensor phase was abolished with time in treated groups. A significant difference (p > 0.05) was observed in control and treated group behavior indicating an excellent activity of the formulation for a longer period (>12 h).
Anacroneuria carchi Stark 2001
Creators: name: Stark, Bill P.
name: Kondratieff, Boris C.
name: Gill, Brian
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Plecoptera
Perlidae
Anacroneuria
Anacroneuria carchi

description: Anacroneuria carchi Stark Anacroneuria carchi Stark 2001:11. Holotype ♂ (CMNH), Chical, Carchi, Ecuador Material examined. Ecuador: Esmeraldas, Cantόn San Lorenzo, Rio Lita, 1830 ft, 00° 51.64’N, 78° 27.16’W, 2 December 2008, R.C. Mower, 2♂ (BYUC). Comments. This species was known previously from the holotype (Stark 2001).
description: Published as part of Stark, Bill P., Kondratieff, Boris C. & Gill, Brian, 2012, New Species And Records Of Anacroneuria (Plecoptera: Perlidae) From Ecuador And Paraguay, pp. 78-93 in Illiesia 8 (6) on page 82, DOI: 10.5281/zenodo.4760778
Do taxonomic, phylogenetic and functional plant α- and β-diversity reflect environmental patterns in the Lower Paraná River floodplain?
Creators: name: Morandeira, Natalia Soledad
name: Kandus, Patricia
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Background: Floodplain wetlands feature high plant biodiversity, comprising variability in several organisation levels and at different scales. Aims: In a large river floodplain, we aimed to answer whether taxonomic, phylogenetic and functional α-diversity of herbaceous assemblages responded to hydrogeomorphic features conditioning the local flood pulse and/or to soil features; and to determine the relationship between β-diversity and geographic and environmental distances. Methods: Taxonomic, phylogenetic and functional α-diversity indices were computed in 82 sites in the Lower Paraná River floodplain. Relationships between α-diversity and environment were explored by generalised linear models. Spatial structure was assessed by semi-variograms. Responses of partitions of β-diversity to geographic or environmental distances were tested through multiple regressions in distance matrices. Results: Taxonomic and phylogenetic α-diversity showed a similar pattern in relation to environment, especially to hydrogeomorphic features. The regression model fitted to species richness had the highest explanatory power. Regarding functional α-diversity, only the number of plant functional types responded to environmental features. Partitions of β-diversity, particularly the replacement of functional strategies, were better explained by environmental than by geographic distances. Conclusions: The diversity patterns of plant assemblages in a large river floodplain highlight the importance of heterogeneity conditioning the local effect of flood pulse regimes.
Relationship between sleeplessness and drug abuse.pdf
Creators: name: Rehman, Atiq Ur
Publisher: name: figshare
Year: 2017
Subjects: subject: 170106 Health, Clinical and Counselling Psychology
subject: FOS: Psychology

description: Objectives:: To investigate the relationship between sleeplessness and drug abuse and to determine the difference in male and female on sleeplessness and drug abuse. Methodology: This was a cross sectional study conducted at Hazara University, Mansehra and Haripur University, Haripur, Khyber Pakhtunkhwa, Pakistan. The sample consisted of 150 university students, including 75 males and 75 females with the age limit of 18-25 years. The sample was taken by using a purposive sampling technique. Pittsburgh Sleep Quality Index and Drug Abuse Screening Test -20 were used in this study. Result: There was a significantly positive correlation between sleep problem and drug abuse (r = .257, p < 0.05). Male students (M = 9.41 ± 2.56) had verse sleep than female ((M = 8.59 ± 2.39), t(148) = 2.03, p < .05 and male students (M = 8.06 ± 4.07) more suffered drug abuse than female students (M = 6.06 ± 4.05), t(148) = 3.02, p < .05. Conclusion: Sleeplessness and drug abuse are positively associated with each other and males are more prone to drug abuse and sleeplessness as compared to females.
Monocyte adhesion induced by multi-walled carbon nanotubes and palmitic acid in endothelial cells and alveolar–endothelial co-cultures
Creators: name: Cao, Yi
name: Roursgaard, Martin
name: Raun Jacobsen, Nicklas
name: Møller, Peter
name: Loft, Steffen
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences

description: Free palmitic acid (PA) is a potential pro-atherogenic stimulus that may aggravate particle-mediated cardiovascular health effects. We hypothesized that the presence of PA can aggravate oxidative stress and endothelial activation induced by multi-walled carbon nanotube (MWCNT) exposure in vitro. We investigated the interaction between direct exposure to MWCNTs and PA on THP-1 monocyte adhesion to human umbilical vein endothelial cells (HUVECs), as well as on indirect exposure in an alveolar–endothelial co-culture model with A549 cells and THP-1-derived macrophages exposed in inserts and the effect measured in the lower chamber on HUVECs and THP-1 cells. The exposure to MWCNTs, including a short (NM400) and long (NM402) type of entangled fibers, was associated with elevated levels of reactive oxygen species as well as a decrease in the intracellular glutathione concentration in HUVEC and A549 monocultures. Both effects were found to be independent of the presence of PA. MWCNT exposure significantly increased THP-1 monocyte adhesion to HUVECs, and co-exposure to PA aggravated the NM400-mediated adhesion but decreased the NM402-mediated adhesion. For the co-cultures, the exposure of A549 cells did not promote THP-1 adhesion to HUVECs in the lower chamber. When THP-1 macrophages were present on the cell culture inserts, there was a modest increase in the adhesion and an increase in interleukin-6 and interleukin-8 levels in the lower chamber whereas no tumor necrosis factor was detected. Overall, this study showed that direct exposure of HUVECs to MWCNTs was associated with oxidative stress and monocyte adhesion and the presence of PA increased the adhesion when exposed to NM400.
Anacroneuria chavin Stark & Sivec 1998
Creators: name: Stark, Bill P.
name: Kondratieff, Boris C.
name: Gill, Brian
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Plecoptera
Perlidae
Anacroneuria
Anacroneuria chavin

description: Anacroneuria chavin Stark & Sivec Anacroneuria chavinStark & Sivec 1998:16. Holotype ♂ (CASC). 67 mi E Tingo Maria, Yurac, Peru Material examined. Ecuador: El Oro, 9 mi S Santa Rosa, 23 January 1955, E.I. Schlinger, E.S. Ross, 11♂ (CASC). Comments. Forewing lengths for these males range from 8-9 mm and the holotype forewing length is 10.5 mm. This difference and subtle differences in the aedeagal apex suggest these specimens may represent a sibling species in this complex. Specifically, the narrow dark markings along the posterior shoulder margins are less distinct for the Ecuadorian specimens and the lateral margins of the aedeagal apex are not constricted at the shoulder as they are in the holotype. A larger sample from the type locality in Peru is needed to more fully evaluate the status of these specimens.
description: Published as part of Stark, Bill P., Kondratieff, Boris C. & Gill, Brian, 2012, New Species And Records Of Anacroneuria (Plecoptera: Perlidae) From Ecuador And Paraguay, pp. 78-93 in Illiesia 8 (6) on page 82, DOI: 10.5281/zenodo.4760778
description: {"references": ["Stark, B. P. & I. Sivec. 1998. Anacroneuria of Peru and Bolivia (Plecoptera: Perlidae). Scopolia, 40: 1 - 64."]}
Demonstrating approaches to chemically modify the surface of Ag nanoparticles in order to influence their cytotoxicity and biodistribution after single dose acute intravenous administration
Creators: name: Pang, Chengfang
name: Brunelli, Andrea
name: Zhu, Conghui
name: Hristozov, Danail
name: Liu, Ying
name: Semenzin, Elena
name: Wang, Wenwen
name: Tao, Wuqun
name: Liang, Jingnan
name: Marcomini, Antonio
name: Chen, Chunying
name: Zhao, Bin
Publisher: name: Taylor & Francis
Year: 2016
Subjects: Biochemistry
Space Science
Medicine
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: With the advance in material science and the need to diversify market applications, silver nanoparticles (AgNPs) are modified by different surface coatings. However, how these surface modifications influence the effects of AgNPs on human health is still largely unknown. We have evaluated the uptake, toxicity and pharmacokinetics of AgNPs coated with citrate, polyethylene glycol, polyvinyl pyrolidone and branched polyethyleneimine (Citrate AgNPs, PEG AgNPs, PVP AgNPs and BPEI AgNPs, respectively). Our results demonstrated that the toxicity of AgNPs depends on the intracellular localization that was highly dependent on the surface charge. BPEI AgNPs (ζ potential = +46.5 mV) induced the highest cytotoxicity and DNA fragmentation in Hepa1c1c7. In addition, it showed the highest damage to the nucleus of liver cells in the exposed mice, which is associated with a high accumulation in liver tissues. The PEG AgNPs (ζ potential = −16.2 mV) showed the cytotoxicity, a long blood circulation, as well as bioaccumulation in spleen (34.33 µg/g), which suggest better biocompatibility compared to the other chemically modified AgNPs. Moreover, the adsorption ability with bovine serum albumin revealed that the PEG surface of AgNPs has an optimal biological inertia and can effectively resist opsonization or non-specific binding to protein in mice. The overall results indicated that the biodistribution of AgNPs was significantly dependent on surface chemistry: BPEI AgNPs > Citrate AgNPs = PVP AgNPs > PEG AgNPs. This toxicological data could be useful in supporting the development of safe AgNPs for consumer products and drug delivery applications.
Anacroneuria cushueme Stark & Gill 2012, sp. n.
Creators: name: Stark, Bill P.
name: Kondratieff, Boris C.
name: Gill, Brian
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Plecoptera
Perlidae
Anacroneuria
Anacroneuria cushueme

description: Anacroneuria cushueme Stark & Gill sp. n. (Figs. 6-10) Material examined. Holotype ♂ and 1♂ paratype, Ecuador, Pastaza, Rio Cushueme, Cushueme, 150 km SE Puyo, 320 m, 15-30 May 1971, B. Malkin (CASC). Adult habitus. General color pale yellow patterned with pale brown. Head pattern indistinct, almost entirely yellow with only slightly darkened lappets (Fig. 6). Pronotum with sublateral pale brown bands; area adjacent to median suture and anterolateral margins pale. Femora pale brown, tibiae slightly darker at apex and base. Wings transparent, veins pale amber. Male. Forewing length 9 mm. Apical section of aedeagus with median, projecting lobe narrowed slightly from base and truncate at tip (Fig. 8). Shoulders strongly sclerotized, bulging laterad; body of aedeagus wider proximal to shoulder bases. Dorsal keel consists of two long, divergent ridges and two pairs of shorter ones near base of longer median keel lines (Fig. 10). Hooks relatively wide and acute. Lateral lobes on apical section project away from aedeagal body, one pair lunate and the other almost quadrate (Fig. 9). Hammer thimble shaped (Fig. 7). Female. Unknown. Larva. Unknown. Etymology. The species name, used as a noun in apposition, is based on the type locality. Diagnosis. Based on aedeagal morphology, this species is related to the A. yameo Stark & Sivec 1998 group of species, which also includes A. pakitza Stark & Sivec 1998, A. pinza Stark 1995, and A. zunigae Stark 2001. The new species bears a greater similarity in aedeagal structure to A. yameo and A. pakitza but in these species the shoulder region bulges toward the aedeagal apex creating an apically trilobed structure; this is quite distinct in the dorsal aspect and differs from the comparable structures in A. cushueme which bulge more laterad. In A. cushueme the mesal projection of the aedeagal apex is truncate at the tip and broad at the base which also differs from both related species.
description: Published as part of Stark, Bill P., Kondratieff, Boris C. & Gill, Brian, 2012, New Species And Records Of Anacroneuria (Plecoptera: Perlidae) From Ecuador And Paraguay, pp. 78-93 in Illiesia 8 (6) on page 82, DOI: 10.5281/zenodo.4760778
description: {"references": ["Stark, B. P. & I. Sivec. 1998. Anacroneuria of Peru and Bolivia (Plecoptera: Perlidae). Scopolia, 40: 1 - 64.", "Stark, B. P. 1995. New species and records of Anacroneuria (Klapalek) from Venezuela. Spixiana, 18: 211 - 249."]}
UO22+-polycarboxylate heterometallic complexes: structure, spectra, and photocatalytic properties
Creators: name: Lin Guan, Qing
name: Gao, Xue
name: Liu, Jing
name: Juan Wei, Wen
name: Heng Xing, Yong
name: Ying Bai, Feng
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: [Cu2(UO2)4(suc)4(pac)4] (1), [(Cu(H2O)2)(4,4′-bipy)2][(UO2)2(H2O)2(Hca)2]·3H2O (2), and [(Cu(H2O)2)(UO2)(bta)]·4H2O (3) were synthesized by the reaction of succinic acid and 3-pyridinecarboxylic acid, citric acid and 4,4′-bipyridine, or 1,2,4,5-benzenetetracarboxylic acid ligands with Cu(NO3)2·3H2O and UO2(CH3COO)2·2H2O. The complexes were characterized by IR and UV–vis spectroscopy, powder X-ray diffraction, single-crystal X-ray diffraction, and photoluminescence spectroscopy. Photocatalytic activities of the complexes were also investigated.
Electric vehicle fast charging with energy storage and generation capabilities - Simulations based on real charging data
Creators: name: Rohde, Lena
Publisher: name: Technische Universität Dortmund
Year: 2020
Subjects: subject: 621.3

description: The increasing use of electric vehicles (EV) brings up the need to invest in the charg- ing infrastructure and extend the number of charging sites and stations. Especially the integration of fast charging sites increases the convenience for the user. The growing utilization of charging sites is also a chance to learn about charging be- haviour and future needs. In this thesis, usage data of a charging site in Norway is processed by a self-developed modelling tool, to create charging profiles based on the measured energy data. Additionally an optimized peak-shaving approach is examined. The capabilities and influence of an integrated battery electric storage (BES) system and a photovoltaic (PV) system on the charging profiles are anal- ysed. The peak-shaving reaches values between 30% and 60% depending on the BES and PV configuration. Based on the results, differences and patterns in the charging behaviour are visible on a weekly and monthly basis. The results of the peak-shaving indicate a correlation of higher peak-shaving with a increasing BES capacity. The PV system introduces more flexibility to the charging site that implies more independence of the grid.
Anacroneuria jewetti Stark 2001
Creators: name: Stark, Bill P.
name: Kondratieff, Boris C.
name: Gill, Brian
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Plecoptera
Perlidae
Anacroneuria
Anacroneuria jewetti

description: Anacroneuria jewetti Stark Anacroneuria jewetti Stark 2001:19. Holotype ♂ (USNM). San Francisco de Borja, Napo, Ecuador Anacroneuria jewetti: Zúñiga et al., 2006:55. Female description Material examined. Ecuador: Imbabura Province, Cantόn Cotacachi, Rio Intag, Apuela, 5020 ft, 00° 21.2’N, 78° 31.0’W, 6 November 2009, S.M. Clark, H.R. Hinkson 8♂ (BYUC). Comments. These specimens are the first to be reported from Imbabura Province.
description: Published as part of Stark, Bill P., Kondratieff, Boris C. & Gill, Brian, 2012, New Species And Records Of Anacroneuria (Plecoptera: Perlidae) From Ecuador And Paraguay, pp. 78-93 in Illiesia 8 (6) on page 85, DOI: 10.5281/zenodo.4760778
description: {"references": ["Zuniga, M. C., B. P. Stark, J. J. Vasconez, F. Berosa, & L. D. Vimos. 2006. Colombian and Ecuadorian Anacroneuria (Plecoptera: Perlidae): seven new species, records and life stages. Studies on Neotropical Fauna and Environment, 41: 45 - 57."]}
Pharmacokinetics, distribution, metabolism, and excretion of the dual reuptake inhibitor [14C]-nefopam in rats
Creators: name: Yu, Jian
name: Solon, Eric
name: Shen, Helen
name: B. Modi, Nishit
name: Mittur, Aravind
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Marine Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: 1. This study examined the pharmacokinetics, distribution, metabolism, and excretion of [14C] nefopam in rats after a single oral administration. Blood, plasma, and excreta were analyzed for total radioactivity, nefopam, and metabolites. Metabolites were profiled and identified. Radioactivity distribution was determined by quantitative whole-body autoradiography. 2. The pharmacokinetic profiles of total radioactivity and nefopam were similar in male and female rats. Radioactivity partitioned approximately equally between plasma and red blood cells. A majority of the radioactivity was excreted in urine within 24 hours and mass balance was achieved within 7 days. 3. Intact nefopam was a minor component in plasma and excreta. Numerous metabolites were identified in plasma and urine generated by multiple pathways including: hydroxylation/oxidation metabolites (M11, M22a and M22b, M16, M20), some of which were further glucuronidated (M6a to M6c, M7a to M7c, M8a and M8b, M3a to M3d); N-demethylation of nefopam to metabolite M21, which additionally undergoes single or multiple hydroxylations or sulfation (M9, M14, M23), with some of the hydroxylated metabolites further glucuronidated (M2a to M2d). 4. Total radioactivity rapidly distributed with highest concentrations found in the urinary bladder, stomach, liver, kidney medulla, small intestine, uveal tract, and kidney cortex without significant accumulation or persistence. Radioactivity reversibly associated with melanin-containing tissues.
Arrêt du parlement de Tournai, qui ordonne aux Échevins de la Ville de Lille, qui seront commissaires aux enquêtes, de les signer à chaque séance, avec le Greffier ou Adjoint, à peine de faux, nullité, Etc.
Creators: name: Plouvain, Pierre-Antoine-Samuel-Joseph (1754-1832)
name: Six, Philippe-Josse-Auguste-Joseph (1732-1793)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2019
Subjects: Organisation judiciaire
Échevin
Greffier

description: Source: http://nordnum.univ-lille.fr/ark:/72505/a0115224001360im5Ol/from/a011522400136ypxWl2
description: Coverage: Parlement de Flandre
description: created: 07/01/2019
description: created: 13/12/1690
Anacroneuria kayceae Kondratieff & Gill 2012, sp. n.
Creators: name: Stark, Bill P.
name: Kondratieff, Boris C.
name: Gill, Brian
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Plecoptera
Perlidae
Anacroneuria
Anacroneuria kayceae

description: Anacroneuria kayceae Kondratieff & Gill sp. n. (Figs. 14-18) Material examined. Holotype ♂, Ecuador, Napo, 6.38 km W Baeza, Hwy E-20, 1,987 m, 0° 27.123’S, 77° 56.468’W, 25 January 2012, B.C. Kondratieff, B. Gill (USNM). Adult habitus. General color pale yellow, white in alcohol. Head with slightly darker, but obscure markings over ocelli, lappets and posterolateral areas of occiput (Fig. 14). Pronotum pale along lateral margins and median suture, but with irregular, dark brown, sublateral bands. Ocelli narrowly separated; wings transparent, veins pale. Legs, antennae and palpi pale. Male. Forewing length 17 mm. Hammer almost cylindrical, but slightly wider at base than apex (Fig. 15). Aedeagal apex truncate, lateral margins slightly expanded and appearing swollen at base (Figs. 16, 18); hooks strongly sclerotized at base with a distinct dark line outlining inner basal margin, and bearing a strong ventral keel from near midlength to near tips. Dorsal keel consists of two close-set, low ridges, extending for about half of apical area length (Fig. 18). In lateral aspect much of aedeagal apex membranous (Fig. 17). Female. Unknown. Larva. Unknown. Etymology. We honor Dr. Kayce Anderson, Colorado State University, for her dedication to ecological studies in Ecuador, and her appreciation of Neotropical aquatic biology. Diagnosis. The aedeagus of this species is similar to that of the Peruvian-Bolivian species, A. pachacuti Stark & Sivec 1998, particularly in lateral aspect. However, in that species the apical section of the aedeagus is offset by prominent basolateral notches and the aedeagal apex is nipple-shaped rather than truncate (see Stark & Sivec 1998, Figs. 124-126). In addition, A. pachacuti is a smaller species (FWL ~ 11 mm) with a slightly darker habitus. The aedeagus is also similar to that of A. rawlinsi Stark, 2001, but in that species the apical aedeagal section lacks swollen basolateral lobes. Comments. The type locality (Figs. 32-33) is described under A. guambiana.
description: Published as part of Stark, Bill P., Kondratieff, Boris C. & Gill, Brian, 2012, New Species And Records Of Anacroneuria (Plecoptera: Perlidae) From Ecuador And Paraguay, pp. 78-93 in Illiesia 8 (6) on page 85, DOI: 10.5281/zenodo.4760778
description: {"references": ["Stark, B. P. & I. Sivec. 1998. Anacroneuria of Peru and Bolivia (Plecoptera: Perlidae). Scopolia, 40: 1 - 64."]}
Noored: Revolutionizing Education with Sustainable Technology
Creators: name: Huda Fathima, Nafha F
Publisher: name: Zenodo
Year: 2025

description: NoorEd is a groundbreaking educational tool designed to empower students with accessibility, sustainability,and functionality. The solar-powered gadget, constructed with recyclable materials like bio-based polymers and e-waste metals, incorporates a study timer, planners, career counseling, and curated instructional notes. With its unique "restriction mode" and integrated AI bot, A.D.U.H., NoorEd ensures a distraction-free and personalized learning experience while promoting eco-friendly practices. This paper explores NoorEd’s innovative design, features, and potential impact on sustainable education, fostering a collaborative and engaging learning environment for students.
Sulfate radicals from Fe3+/persulfate system for Rhodamine B degradation
Creators: name: Lu, Yongsheng
name: Yang, Xingxing
name: Xu, Lu
name: Wang, Zhan
name: Xu, Yunfeng
name: Qian, Guangren
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Virology

description: The Fe3+/persulfate system for Rhodamine B (RhB) oxidative degradation has been investigated. The catalytic mechanism in the Fe3+/persulfate system was proposed as follows: Fe3+ was restored to Fe2+ by the generated intermediate products during the degradation process. The influence parameters were examined in batch experiments, including Fe3+ and persulfate concentration and initial pH. The results indicated that the Fe3+/persulfate system exhibited good performance for RhB degradation and followed first-order kinetics. 95.91% of the RhB was removed within 30 min under the following conditions: [Fe3+]0 = 1 mM, [persulfate]0 = 1 mM and pH 3.0. The RhB degradation efficiencies increased as the Fe3+ and persulfate concentrations increased. In addition, the RhB degradation was inhibited in the presence of inorganic anions, which was primarily due to a complex reaction between Fe3+ and various anions except for .
Ranking of 38 prokaryotes according to their uranium uptake capacity in aqueous solutions: an approach from order theory through the Hasse diagram technique
Creators: name: Quintero, Nancy Y.
name: Bruggemann, Rainer
name: Restrepo, Guillermo
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Uranium contamination is of global concern and several approaches have been applied to cleanse U-contaminated ecosystems. Among them, biotechnological techniques using microorganisms have proven to be eco-friendly. However, knowing which of them behave better for U trapping is still an open question. In this study, a general and a detailed comparison of prokaryotes, differentiated by growth and U uptake conditions, was performed. The general comparison was run over 38 species characterized by different conditions and a subset of 18 bacteria having equal conditions was compared in detail. In both cases, the species were characterized by their percentage of U removal, uptake capacity, and time required for removing U. The methodology used was the Hasse diagram technique, suitably adjusted to address the issue of ordering objects (microorganisms) whose attributes contain interval values. Microorganisms were ranked and a stable top-five of bacteria for U trapping from aqueous systems was obtained: Bacillus licheniformis ATCC 14580, Bacillus mucilaginosus ACCC 10012, Pseudomonas MGF-48, Streptomyces sp., and Pseudomonas sp. EPS-5028. The results show that neither the Gram nor the taxonomic classification determines uptake capacity for the species studied. The method here described can be further applied to other attributes of relevance for the selection of optimal microorganisms, e.g. economical ones.
Mathematical modeling for local trans-round window membrane drug transport in the inner ear
Creators: name: Zhang, Yue
name: Su, Huanpeng
name: Wen, Lu
name: Yang, Fan
name: Chen, Gang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: The structure and composition of the round window membrane (RWM) make it a particularly effective pathway for drug delivery to the inner ear. Therefore, predicting the efficiency of RWM transport would provide useful information for enhancing local application. In the present study, a mathematical model was established to achieve this goal. A series of drugs with different physicochemical properties were introduced in the inner ear cavity of guinea pigs via RWM by intratympanic application. The perilymphatic drug concentration (C) data were used to calculate the permeability coefficient (Kp) of different drugs diffusing through the RWM. The experimental data were fitted using the Matlab software to set up the numerical model based on Fick’s diffusion law and the single-compartment model following extravascular administration, which facilitated the prediction of the permeation profiles of different drugs while trans-RWM. In summary, this mathematical model is a contribution toward developing potentially useful RWM administration simulating tools.
Dataset from Increased food availability raises eviction rate in a cooperative breeding mammal
Creators: name: C. Dubuc
name: S. English
name: N. Thavarajah
name: B. Dantzer
name: S. P. Sharp
name: H. C. Spence-Jones
name: D. Gaynor
name: T. H. Clutton-Brock
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: In group-living mammals, the eviction of subordinate females from breeding groups by dominants may serve to reduce feeding competition or to reduce breeding competition. Here, we combined both correlational and experimental approaches to investigate whether increases in food intake by dominant females reduces their tendency to evict subordinate females in wild meerkats (Suricata suricatta). We used 20 years of long-term data to examine the association between foraging success and eviction rate, and provisioned dominants females during the second half of their pregnancy, when they most commonly evict subordinates. We show that rather than reducing the tendency for dominants to evict subordinates, foraging success of dominant females is positively associated with the probability that pregnant dominant females will evict subordinate females and that experimental feeding increased their rates of eviction. Our results suggest that it is unlikely that the eviction of subordinate females serves to reduce feeding competition and that its principal function may be to reduce reproductive competition. The increase in eviction rates following experimental feeding also suggests that rather than feeding competition, energetic constraints may normally constrain eviction rates.
title: 03_0722
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Efficacy and safety of a premixed versus a basal-plus insulin regimen as intensification for type 2 diabetes by timing of the main meal
Creators: name: Gross, Jorge L.
name: Rojas, Arturo
name: Shah, Sanjiv
name: Tinahones, Francisco J.
name: Cleall, Simon
name: Rodríguez, Angel
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Computational Biology

description: Objective: To describe the efficacy and safety of premixed insulin lispro protamine suspension 75%/insulin lispro solution 25% (LM25) twice daily (bid) versus basal insulin glargine plus prandial insulin lispro (IGL), both once daily, according to main meal timing. Methods: Data were obtained post hoc from a 24 week, randomized, open-label study comparing LM25 and IGL as insulin intensification in patients with type 2 diabetes inadequately controlled with once daily basal insulin glargine plus metformin and/or pioglitazone (ClinicalTrials.gov identifier: NCT01175824). Patients administered LM25 bid before breakfast and the evening meal, insulin glargine at bedtime and insulin lispro before the day’s main meal (meal with the highest 2 hour postprandial glucose level during screening). Patients were grouped by main meal. Changes in glycosylated hemoglobin (HbA1c) and bodyweight were summarized using likelihood-based mixed models; hypoglycemia incidence was compared between treatments using Fisher’s exact test. Results: Overall, 476 patients (LM25, n = 236; IGL, n = 240) were randomized. In all main meal groups, with both insulin regimens, mean HbA1c significantly decreased from baseline to 24 weeks (p < 0.0001). Patients whose main meal was in the evening had a greater bodyweight increase with LM25 than with IGL (p = 0.015), and a smaller proportion of these patients experienced total (p = 0.027) and nocturnal (p = 0.006) hypoglycemia with LM25 compared with IGL. Patients whose main meal was lunch experienced more nocturnal hypoglycemia with LM25 than with IGL (p = 0.030). Study limitations include that this was a post hoc analysis and no assessments ensured that: SMBG results determined timing of the main meal, each patient’s main meal remained unchanged throughout the study, or patients administered insulin lispro with that meal. Conclusions: Glycemic control improved in patients receiving either LM25 or IGL, irrespective of main meal timing. Both regimens can be used in patients with inadequate glycemic control who are in need of insulin intensification.
Additional file 1 of RNA-seq coupling two different methods of castration reveals new insights into androgen deficiency-caused degeneration of submaxillary gland in male Sprague Dawley rats
Creators: name: Han, Xingfa
name: Xia, Xue
name: Zhuo, Yong
name: Hua, Lun
name: Yu, Guozhi
name: Bu, Guixian
name: Cao, Xiaohan
name: Du, XiaoGang
name: Liang, Qiuxia
name: Zeng, Xianyin
name: Meng, Fengyan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Additional file 1. qPCR Primer sequences for tissue genes.
Additional file 5 of RNA-seq coupling two different methods of castration reveals new insights into androgen deficiency-caused degeneration of submaxillary gland in male Sprague Dawley rats
Creators: name: Han, Xingfa
name: Xia, Xue
name: Zhuo, Yong
name: Hua, Lun
name: Yu, Guozhi
name: Bu, Guixian
name: Cao, Xiaohan
name: Du, XiaoGang
name: Liang, Qiuxia
name: Zeng, Xianyin
name: Meng, Fengyan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Additional file 5. The code to plot the bubble figures for gene functional enrichment analysis results from DAVID.
Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling
Creators: name: Zhang, Nannan
name: Li, Zhongchi
name: Mu, Wei
name: Li, Liyuan
name: Liang, Yaru
name: Lu, Maoyang
name: Wang, Zhuoran
name: Qiu, Ying
name: Wang, Zhao
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Calorie restriction (CR) extends lifespan from yeast to mammals. SIRT6 is a member of the sirtuin family of NAD+-dependent histone deacetylases, which is responsible for mediating the effects of CR. The transcription factor NF-κB, which is involved in inflammation and aging, has been shown to be regulated by SIRT6. Here we describe the crucial role of SIRT6 in aging and inflammation. We show that CR had improved renal insufficiency and enhanced SIRT6 expression after 6-month treatment in aged mice. Culture cells in low glucose (LG) conditions also showed resistance to cell senescence and enhanced SIRT6 expression compared to normal glucose (NG) group, showing beneficial effects of the CR-mimic cultural conditions. Moreover, SIRT6 overexpression is sufficient to delay the replicative senescence of WI38 by attenuating NF-κB signaling, while SIRT6 knockdown results in accelerated cell senescence and overactive NF-κB signaling. These findings confirm the key status of CR and disclose the critical role of SIRT6 on aging and inflammation.
Additional file 6 of RNA-seq coupling two different methods of castration reveals new insights into androgen deficiency-caused degeneration of submaxillary gland in male Sprague Dawley rats
Creators: name: Han, Xingfa
name: Xia, Xue
name: Zhuo, Yong
name: Hua, Lun
name: Yu, Guozhi
name: Bu, Guixian
name: Cao, Xiaohan
name: Du, XiaoGang
name: Liang, Qiuxia
name: Zeng, Xianyin
name: Meng, Fengyan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Additional file 6. Supplementary statement docx.
A measure of agreement across numerous conditions: Reproducibility of co-expression networks across tissues
Creators: name: Caceres, Alejandro
Publisher: name: figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 60408 Genomics
subject: 60109 Proteomics and Intermolecular Interactions (excl. Medical Proteomics)

description: Manuscript can be found in Biorxiv at

http://biorxiv.org/content/early/2017/04/18/125450
Morphology, ultrastructure and phylogenetic affinities of the single-island endemic Anthoceros cristatus Steph. (Ascension Island)
Creators: name: J. C. Villarreal
name: J. G. Duckett
name: S. Pressel
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology

description: Oceanic islands, due to their geographical isolation, number, precisely defined boundaries and their geomorphological and climatic diversity, have provided enormous insights into speciation, dispersal, adaptive radiations and macroecological processes. One of the key components of these island studies is the role of single-island endemics (SIEs) as, in many instances, island biogeography models use the proportion of SIEs to infer evolutionary processes. It is, therefore, imperative to undertake critical taxonomic revisions to evaluate SIEs because changes in the number of SIEs have a key impact on downstream biogeographic analyses. We revise the special case of a putative SIE Anthoceros cristatus on Ascension Island using light and electron microscopy, as well phylogenomic tools. A. cristatus lies within the A. agrestis/A. punctatus complex but differs from the sister species A. agrestis and A. punctatus in spore morphology and gametophytic lamellae fringed with caducous marginal cells. The present confirmation, from both molecules and morphology, of the SIE status of Anthoceros cristatus and its restricted distribution on the Island makes the preservation of its habitat a conservation priority. Ascension Island is the tip of an undersea volcano that is thought to have emerged from the ocean 1 million years ago with an area of approximately 91 km2, with Green Mountain as the highest elevation (∼859 m a.s.l.). Ascension has a relative low bryophyte species diversity of 87 spp but this includes 12 endemics (∼14%); a much higher level of endemism than on the far more speciose Macaronesian Islands.