cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Food group intake and risk of subtypes of esophageal and gastric cancer
Creators: name: Gammon, Marilee D.
name: Stanford, Janet L.
name: Risch, Harvey
name: Mayne, Susan T.
name: Dubrow, Robert
name: Navarro Silvera, Stephanie A.
name: Fraumeni, Joseph F.
name: Schoenberg, Janet B.
name: West, A. Brian
name: Vaughan, Thomas L.
name: Blot, William J.
name: Chow, Wong-Ho
name: Rotterdam, Heidrun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Incidence rates for adenocarcinomas of the esophagus and gastric cardia have been increasing rapidly, while rates for non-cardia gastric adenocarcinoma and esophageal squamous cell carcinoma have declined. We examined food group intake as a risk factor for subtypes of esophageal and gastric cancers in a multicenter, population-based case-control study in Connecticut, New Jersey and western Washington state. Associations between food groups and risk were estimated using adjusted odds ratios (OR), based on increasing intake of one serving per day. Total vegetable intake was associated with decreased risk of esophageal adenocarcinoma (OR = 0.85, 95% CI = 0.75, 0.96). Conversely, total meat intake was associated with increased risk of esophageal adenocarcinoma (OR = 1.43, 95% CI = 1.11, 1.83), gastric cardia adenocarcinoma (OR = 1.37, 95% CI = 1.08, 1.73) and noncardia gastric adenocarcinoma (OR = 1.39, 95% CI = 1.12, 1.71), with red meat most strongly associated with esophageal adenocarcinoma risk (OR = 2.49, 95% CI = 1.39, 4.46). Poultry was most strongly associated with gastric cardia adenocarcinoma (OR = 1.89, 95% CI = 1.15, 3.11) and noncardia gastric adenocarcinoma (OR = 1.90, 95% CI = 1.19, 3.03). High-fat dairy was associated with increased risk of both esophageal and gastric cardia adenocarcinoma. Higher intake of meats, particularly red meats, and lower intake of vegetables were associated with an increased risk of esophageal adenocarcinoma, while higher intake of meats, particularly poultry, and high-fat dairy was associated with increased risk of gastric cardia adenocarcinoma.
title: Journal Bildende Kunst.Gestaltung.Musik.Bühne.Wissen
Creators: name: Universität Der Künste Berlin
Publisher: name: Verlag der Universität der Künste Berlin
Year: 2023
Subjects: subject: 700 Künste; Bildende und angewandte Kunst

description: Ausgabe 22 (2023, Winter)
description: Journal Bildende Kunst.Gestaltung.Musik.Bühne.Wissen; 2023, Winter
Additional file 1 of Adaption and reliability of the Nutrition Environment Measures for stores (NEMS-S) instrument for use in urban areas of Chile
Creators: name: Granfeldt, Gislaine
name: Victoriano, Montserrat
name: Carrasco, Juan Antonio
name: Sáez, Katia
name: Bibiloni, Maria del Mar
name: Tur, Josep A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1.
Die vier Elemente: Eine psychologische Betrachtung
Creators: name: Funke, Joachim
Publisher: name: Heidelberger Jahrbücher Online
Year: 2022

description: Die vier Elemente Erde, Feuer, Wasser und Luft haben aus psychologischer Sicht nicht zufällig einen prominenten Platz in der menschlichen Ideengeschichte erhalten (nach heutigem Kenntnisstand gibt es 118 Elemente). Es werden kognitive Vereinfachungsmechanismen beschrieben, die als Komplexitätsreduktion gelten dürfen. Daneben kommen soziale Aspekte der Ausbeutung der vier Elemente zur Sprache (Allmendeklemme). Schließlich geht es auch um das Verhältnis des Menschen zur Natur, die sich in den vier Elementen widerspiegelt und die auch unter therapeutischen Aspekten betrachtet werden kann.
description: Heidelberger Jahrbücher Online, Bd. 7 (2022): Die vier Elemente
Multiple pathways for Epstein-Barr virus episome loss from nasopharyngeal carcinoma
Creators: name: Gulley, Margaret L.
name: Chen, Min
name: Dittmer, Dirk P.
name: Hilscher, Chelsey J.
name: Glaser, Ronald
name: Yang, Eric V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Epstein-Barr virus (EBV) is the prototypical example for episomal persistence of genetic information. Yet, little is known about how this viral episome is lost. Episome loss occurs naturally in naso-pharyngeal carcinoma (NPC) upon explantation into culture. Using whole-genome profiling, we found evidence for 2 different pathways of episome loss: (i) rapid loss of the entire episome or (ii) successive mutation/deletion of the episome until at least 1 essential cis-element is destroyed. This second phenotype was seen in a clone of HONE-1 NPC cells that maintains the EBV episome for prolonged time in culture. The conceptual insights provided by our quantitative analysis should aid our understanding of mammalian episomes, as well as lead to designs to cure latent viral infection.
Erde, Luft, Wasser und Feuer – Wie Pflanzen diese Elemente nutzen
Creators: name: Erbar, Claudia
name: Leins, Peter
Publisher: name: Heidelberger Jahrbücher Online
Year: 2022

description: Es sind die klassischen vier Elemente der großen griechischen Philosophen, die – entmythologisiert – sich in heutiger Sicht als Schauplätze organismischer Evolution präsentieren. Mit ihren unterschiedlichen physikalischen und chemischen Qualitäten bilden sie die abiotischen Umweltfaktoren, an die sich Organismen durch zufällige genetische Veränderungen im Laufe der Evolution anpassen können. Andererseits können die ständig sich ändernden Umweltfaktoren immer wieder Organismenarten zum Aussterben zwingen. Wasser ist das Element, in dem das Leben entstand und sehr lange Zeit auch das alleinige Substrat für Pflanzen war. Die ältesten Landpflanzen-Fossilien kennen wir aus dem Oberen Silur, sind also mehr als 400 Millionen Jahre alt. Sie hatten allgemein dasselbe Bauprinzip, nämlich im Querschnitt runde Stiele, die sich mehrfach räumlich-gabelig verzweigen und einen sog. Telomstand bilden, von dem sich im Verlauf des Devons durch unterschiedliche Formveränderungen (sogenannte Elementarprozesse) u.a. die Bärlappe und Wedelfarne ableiten lassen, die im Karbon ihren Höhepunkt erreichten. Mit dem Landgang der Pflanzen erobern sie gleichzeitig das Element Luft. Unterschiedliche Feuchtigkeitsgrade und Temperaturen dieses Elements „zwingen“ die Pflanzen (aufgrund zufälliger Erbänderungen und anschließender dem Optimierungsprinzip gehorchender Selektion) zu unterschiedlichsten Anpassungen. Kompromisse zwischen „Hungern“ und „Dursten“ finden sich vielfach an ariden Wuchsorten. Das meist zerstörerische Element Feuer bildet als „Feuerball“ Sonne eine für das Pflanzenleben unabdingbare Lichtquelle. Sogar das offene Feuer kann von Pflanzen in Gebieten regelmäßig auftretender Buschbrände zur Samenausbreitung in genialer Weise genutzt werden. Die „Verschmutzung“ der genannten Elemente, insbesondere des Wassers, der Luft und des Bodens, oft verursacht von ethisch entkernten Großkonzernen, stellt uns heutzutage vor fast unüberwindbare Probleme (Klimawandel, Insektensterben, Rückgang der Biodiversität insgesamt, „versaute“ Nahrungsmittel).
description: Heidelberger Jahrbücher Online, Bd. 7 (2022): Die vier Elemente
title: The impact of sovereign rating changes on firm activities
Creators: name: Nguyen, Minh Anh
Publisher: name: University of Reading
Year: 2025

description: This thesis examines the impact of sovereign rating changes on domestic firms’ activities. The first empirical chapter investigates the impacts of sovereign ratings on corporate investments. Prior literature focuses on the sovereign ceiling in explaining sovereign-corporate spillovers. I find that government debt overhang is another important channel for the spillovers. Specifically, firms domiciled in a recently downgraded sovereign reduce investments, even if their credit ratings were unchanged following the negative sovereign rating event. Public debt overhangs exacerbate negative impacts of sovereign downgrades on corporate investments. The next chapter examines heterogeneous effects of sovereign rating actions on investments. High leverages magnify negative impacts of sovereign downgrades. Poorer performance, lower investment opportunities and financial constraints are factors reducing a firm’s capacity to buffer the negative leverageinvestment relationship following sovereign downgrades. Cash holdings are associated with higher levels of investment for high leveraged firms following sovereign downgrades. The final empirical investigation is on the relationship between sovereign downgrades and corporate trade credit policies. Firms increase their trade credit following sovereign downgrades. The impact of sovereign downgrade on corporate trade credit is consistent and broadly independent of firms’ products, degrees of financial constraints and market power. Further investigations find that credit extensions are related to different public debt-to-GDP levels during sovereign downgrade periods. In summary, sovereign rating changes plays an important role in firm behaviours, even in cases of firms without credit rating change following the sovereign event. This thesis raises caveats against excessive fiscal expansions for demand stimulus given the negative externals on corporate sectors, hence, negative implications for the aggregate supply. Regulatory attentions on corporate leverages, trade credit and risk management policies are among important practical implications.
Additional file 1 of Adaption and reliability of the Nutrition Environment Measures for stores (NEMS-S) instrument for use in urban areas of Chile
Creators: name: Gislaine, Granfeldt M.
name: Montserrat, Victoriano R.
name: Carrasco, Juan Antonio
name: Sáez, Katia C.
name: Bibiloni, Maria del Mar
name: Tur, Josep A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1.
Racial/ethnic variation in EBV-positive classical Hodgkin lymphoma in California populations
Creators: name: Glaser, Sally L.
name: Mann, Risa B.
name: Keegan, Theresa H.
name: Anton-Culver, Hoda
name: Craig, Fiona E.
name: Shema, Sarah J.
name: Gulley, Margaret L.
name: Clarke, Christina A.
name: Ambinder, Richard F.
name: Dorfman, Ronald F.
name: Chang, Ellen T.
name: DiGiuseppe, Joseph A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Epstein-Barr virus (EBV) is detected in the tumor cells of some but not all Hodgkin lymphoma (HL) patients, and evidence indicates that EBV-positive and –negative HL are distinct entities. Racial/ethnic variation in EBV-positive HL in international comparisons suggests etiologic roles for environmental and genetic factors, but these studies used clinical series and evaluated EBV presence by differing protocols. Therefore, we evaluated EBV presence in the tumors of a large (n=1,032), racially and sociodemographically diverse series of California incident classical HL cases with uniform pathology re-review and EBV detection methods. Tumor EBV-positivity was associated with Hispanic and Asian/Pacific Islander (API) but not black race/ethnicity, irrespective of demographic and clinical factors. Complex race-specific associations were observed between EBV-positive HL and age, sex, histology, stage, neighborhood socioeconomic status (SES), and birth place. In Hispanics, EBV-positive HL was associated not only with young and older age, male sex, and mixed cellularity histology, but also with foreign birth and lower SES in females, suggesting immune function responses to correlates of early childhood experience and later environmental exposures, respectively, as well as of pregnancy. For APIs, a lack of association with birth place may reflect the higher SES of API than Hispanic immigrants. In blacks, EBV-positive HL was associated with later-stage disease, consistent with racial/ethnic variation in certain cytokine polymorphisms. The racial/ethnic variation in our findings suggests that EBV-positive HL results from an intricate interplay of early- and later-life environmental, hormonal, and genetic factors leading to depressed immune function and poorly controlled EBV infection.
The gaugino condensate from asymmetric four-torus with twists
Creators: name: Anber, Mohamed M.
name: Poppitz, Erich
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We calculate the gaugino condensate in $SU(2)$ super Yang-Mills theory on an asymmetric four-torus $\mathbb T^4$ with 't Hooft's twisted boundary conditions. The $\mathbb T^4$ asymmetry is controlled by a dimensionless detuning parameter $Δ$, proportional to $L_3 L_4 - L_1 L_2$, with $L_i$ denoting the $\mathbb T^4$ periods. We perform our calculations via a path integral on a $\mathbb T^4$. Its size is taken much smaller than the inverse strong scale $Λ$ and the theory is well inside the semi-classical weak-coupling regime. The instanton background, constructed for $Δ\ll 1$ in arXiv:hep-th/0007113, has fractional topological charge $Q=\frac{1}{2}$ and supports two gaugino zero modes, yielding a non-vanishing bilinear condensate, which we find to be $Δ$-independent. Further, the theory has a mixed discrete chiral/$1$-form center anomaly leading to double degeneracy of the energy eigenstates on any size torus with 't Hooft twists. In particular, there are two vacua, $|0\rangle$ and $|1\rangle$, that are exchanged under chiral transformation. Using this information, the $Δ$-independence of the condensate, and assuming further that the semi-classical theory is continuously connected to the strongly-coupled large-$\mathbb T^4$ regime, we determine the numerical coefficient of the gaugino condensate: $\langle 0| \mbox{tr}λλ|0\rangle=|\langle 1| \mbox{tr}λλ|1\rangle|=32π^2 Λ^3$, a result equal to twice the known $\mathbb R^4$ value. We discuss possible loopholes in the continuity approach that may lead to this discrepancy.
description: 30 pages+appendices; typos corrected, references added, matches published version
Additional file 1 of Getting in control of persistent, mobile and toxic (PMT) and very persistent and very mobile (vPvM) substances to protect water resources: strategies from diverse perspectives
Creators: name: Hale, Sarah E.
name: Neumann, Michael
name: Schliebner, Ivo
name: Schulze, Jona
name: Averbeck, Frauke S.
name: Castell-Exner, Claudia
name: Collard, Marie
name: Drmač, Dunja
name: Hartmann, Julia
name: Hofman-Caris, Roberta
name: Hollender, Juliane
name: de Jonge, Martin
name: Kullick, Thomas
name: Lennquist, Anna
name: Letzel, Thomas
name: Nödler, Karsten
name: Pawlowski, Sascha
name: Reineke, Ninja
name: Rorije, Emiel
name: Scheurer, Marco
name: Sigmund, Gabriel
name: Timmer, Harrie
name: Trier, Xenia
name: Verbruggen, Eric
name: Arp, Hans Peter H.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 1. Additional file consisting of figures, tables and text.
Two Quantum Proxy Blind Signature Schemes Based on Controlled Quantum Teleportation
Creators: name: Luo, Qiming
name: Zhang, Tinggui
name: Huang, Xiaofen
name: Jing, Naihuan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a scheme for teleporting an unknown, two-particle entangled state with a message from a sender (Alice) to a receiver (Bob) via a six-particle entangled channel. We also present another scheme for teleporting an unknown one-particle entangled state with a message transmitted in a two-way form between the same sender and receiver via a five-qubit cluster state. One-way hash functions, Bell-state measurements, and unitary operations are adopted in these two schemes. Our schemes use the physical characteristics of quantum mechanics to implement delegation, signature, and verification processes. Moreover, a quantum key distribution protocol and a one-time pad are adopted in these schemes.
description: 8 pages; no figure
THE INCIDENCE OF PARTIAL EDENTULISM AND DENTURE STATUS AMONG MONGOLIANS
Creators: name: MARALGOO P
name: GANJARGAL G
name: GANTUMUR CH
name: BATBAYAR B
name: PUREVJAV N
name: JAVKHLAN P
Publisher: name: Zenodo
Year: 2023
Subjects: Tooth Mortality, Prosthodontic Treatment, Kennedys Classification, Tooth Loss Level, Partial Edentulism.

description: Abstract
Introduction: Since 2013, the prevalence of tooth loss among adults in rural areas has not been studied in Mongolia. Therefore, our goal of the survey was to determine the level of tooth loss and denture needs among the population of Mongolia's. Materials and Methods: According to the geographical region of Mongolia, 1638 subjects over 18 years old were examined from target provinces and their partial edentulous status and denture status were determined. Results: The prevalence of partial edentulous level in total subjects was 1478 (90.2%), and partial edentulous level was high (93.5%) in over < 45 year-olds. The incidence of Kennedy's class in both arches was 880 (36.0%), Class III was 853 (34.8%), and Class II was 675 (27.6%), respectively. Class IV was lower at 40 (1.6%) in both dental arches (P< 0.01). Evaluating denture status in people: 435 (67.8%) have acrylic dentures and 171 (26.6%) have flexible dentures. The number of subjects who needed prosthetic treatment was 861 (57.3%). Conclusion: The level and pattern of partial edentulism among adults Mongolia were high, and the level and pattern of tooth loss were significantly associated with age groups. Prosthetic needs among rural people are high, and all these findings are also being considered in oral health promotion strategies designed to reduce tooth loss in Mongolia's adults.
Die vier Elemente in der Bibel: Luft, Wasser, Erde, Feuer
Creators: name: Diebner, Bernd Jørg
Publisher: name: Heidelberger Jahrbücher Online
Year: 2022

description: Als Autoren literarischer Dokumente der Antike kennen die Verfasser der biblischen Schriften Alten und Neuen Testamentes auch die seit etwa dem 5. Jahrhundert vor Christus vor allem durch griechische Philosophen definierten vier Grundsubstanzen Luft, Erde, Feuer und Wasser. Das zeigt sich bereits in der Schöpfungsgeschichte Genesis / 1. Buch Moses, Kap. 1, also gleich zu Beginn der Bibel, und im Vergleich dieser mit der Schöpfungs-Hierarchie des Aristoteles. – Für meine Darstellung habe ich die Reihenfolge Luft, Feuer, Wasser, Erde gewählt und noch zwei ,biblische Elemente = Grundsubstanzen' hinzugefügt: Licht und Finsternis in ihrer Bezogenheit aufeinander. Auffällig am biblischen Befund ist, dass alle Elemente (einschliesslich von Licht und Finsternis, aber ausschliesslich von Erde, es sei denn, man betrachte die ,Erdenfrucht' Brot als ,Erde') Symbole für Gott sein können, ja als mit Ihm identisch formuliert werden können, bis hin zu der Spitzen-Aussage: „Gott ist Licht“. Gott kann aber auch ,Luft' sein, oder sich im ,Feuer' oder durch ,Wasser' offenbaren. Oder Gott kann wesenlos im Dunkel vegetieren. In der ,Erdenfrucht Brot' kann man Gottes Leib im Hl. Abendmahl / der Eucharistie verspeisen. Aber auch zum Wohle der Menschen oder zu ihrer Bestrafung sind die Elemente immer in Gottes Hand. Der Aufsatz soll dies differenzierend zeigen.
description: Heidelberger Jahrbücher Online, Bd. 7 (2022): Die vier Elemente
FAK overexpression and p53 mutations are highly correlated in human breast cancer
Creators: name: Golubovskaya, Vita M.
name: Moore, Dominic
name: Cance, William G.
name: Lark, Amy A.
name: Conway-Dorsey, Kathleen
name: Millikan, Robert C.
name: Tse, Chiu-Kit
name: Edmiston, Sharon N.
name: Livasy, Chad A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Focal Adhesion Kinase (FAK) is overexpressed in a number of tumors, including breast cancer. Another marker of breast cancer tumorigenesis is the tumor suppressor gene p53 that is frequently mutated in breast cancer. In the present study, our aim was to find a correlation between FAK overexpression, p53 expression and mutation status in a population-based series of invasive breast cancer tumors from the Carolina Breast Cancer Study. Immunohistochemical analyses of 622 breast cancer tumors revealed that expression of FAK and p53 were highly correlated (P = 0.0002) and FAK positive tumors were 1.8 times more likely to be p53 positive compared to FAK negative tumors [odds ratio (OR) = 1.8; 95% Confidence Interval (CI) 1.2 – 2.8, adjusted for age, race and stage at diagnosis]. Tumors positive for p53 expression showed higher intensity of FAK staining (P<0.0001) and higher percent of FAK positive staining (P<0.0005). From the same study, we evaluated 596 breast tumors for mutations in the p53 gene, using SSCP (single strand conformational polymorphism) and sequencing. Statistical analyses were performed to determine the correlation between p53 mutation status and FAK expression in these tumors. We found that FAK expression and p53 mutation were positively correlated (P<0.0001) and FAK positive tumors were 2.5 times more likely to be p53 mutation positive compared to FAK negative tumors [adjusted OR = 2.5, 95% CI 1.6–3.9]. This is the first analysis demonstrating a high correlation between FAK expression and p53 mutations in a population-based series of breast tumors.
Family history of cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
Creators: name: Eluf-Neto, Jose
name: Lissowska, Jolanta
name: Olshan, Andrew F.
name: Fabianova, Eleonora
name: Talamini, Renato
name: Fernandez, Leticia
name: Maso, Luigino Dal
name: Franceschi, Silvia
name: Zaridze, David
name: Szeszenia-Dabrowska, Neonilia
name: Matos, Elena
name: Daudt, Alexander W.
name: Muscat, Joshua
name: Koifman, Sergio
name: Lazarus, Philip
name: Menezes, Ana
name: Hayes, Richard B.
name: Lence, Juan J.
name: Curado, Maria Paula
name: Herrero, Rolando
name: Boffetta, Paolo
name: Mates, Dana
name: Winn, Deborah M.
name: Shangina, Oxana
name: Levi, Fabio
name: Rudnai, Peter
name: Sturgis, Erich M.
name: Negri, Eva
name: Wei, Qingyi
name: Wünsch-Filho, Victor
name: Castellsague, Xavier
name: Berthiller, Julien
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Alcohol and tobacco consumption are well recognized risk factors for head and neck cancer (HNC). Evidence suggests that genetic predisposition may also play a role. Only a few epidemiologic studies, however, have considered the relation between HNC risk and family history of HNC and other cancers. We pooled individual- level data across 12 case-control studies including 8,967 HNC cases and 13,627 controls. We obtained pooled odds ratios (OR) using fixed and random effect models, and adjusting for potential confounding factors. All statistical tests were two-sided. A family history of HNC in first-degree relatives increased the risk of HNC (OR=1.7, 95% confidence interval, CI, 1.2-2.3). The risk was higher when the affected relative was a sibling (OR=2.2, 95% CI 1.6-3.1) rather than a parent (OR=1.5, 95% CI 1.1-1.8), and for more distal HNC anatomic sites (hypopharynx and larynx). The risk was also higher, or limited to, subjects exposed to tobacco. The OR rose to 7.2 (95% CI 5.5-9.5) among subjects with family history, who were alcohol and tobacco users. A weak but significant association (OR=1.1, 95% CI 1.0-1.2) emerged for family history of other tobacco-related neoplasms, particularly with laryngeal cancer (OR=1.3, 95% CI 1.1-1.5). No association was observed for family history of non-tobacco related neoplasms and the risk of HNC (OR=1.0, 95% CI 0.9-1.1). Familial factors play a role in the etiology of HNC. In both subjects with and without family history of HNC, avoidance of tobacco and alcohol exposure may be the best way to avoid HNC.
IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas
Creators: name: Chow, Wong-Ho
name: Jirtle, Randy L.
name: Calingeart, Brian
name: Schildkraut, Joellen M.
name: Mayne, Susan
name: Marks, Jeffrey R.
name: Hoyo, Cathrine
name: Fraumeni, Joseph
name: Gammon, Marilie D.
name: Vaughan, Thomas L.
name: Risch, Harvey
name: Murphy, Susan K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The mannose 6 phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes a protein that plays a critical role in tumor suppression, in part by modulating bioavailability of a potent mitogen, insulin-like growth factor-2 (IGF2). We tested the hypothesis that the common non-synonymous genetic variants in M6P/IGF2R c.901C>G (Leu>Val) in exon 6 and c.5002G>A (Gly>Arg) in exon 34 are associated with risk of esophageal and gastric cancers. Study participants in this population-based study comprise 197 controls and 182 cases, including 105 with esophageal-gastric cardia adenocarcinoma (EGA), 57 with non-cardia gastric adenocarcinoma and 20 with esophageal squamous cell carcinoma (ES). Among white males, odds ratios (ORs) were elevated in relation to carrying at least one c.901C>G allele for EGA (OR= 1.9; 95%CI=1.0–3.6) and non-cardia gastric cancer (OR=2.5; 95%CI=1.2–5.5), but not ES. Exploratory subgroup analyses suggested that associations between EGA and this variant were stronger among irregular or non-users of non-steroidal anti-inflammatory drugs (NSAIDs) (OR=2.3; 95%CI=1.2–4.2) and cigarette smokers (OR=2.1; 95%CI=1.0–4.2). An association between carrying the c.5002G>A genotype and EGA was not evident. These findings suggest that non-synonymous polymorphisms in M6P/IGF2R may contribute to the risks of EGA and non-cardia adenocarcinomas. Larger studies are required to confirm these findings.
Highlight report: New insights in liver physiology: Canalicular bile flux is diffusion dominated
Creators: name: Ezzat Ahmed, Ahmed
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: liver physiology
canalicular bile flux

description: One of the central functions of the liver is excretion of bile into the intestine. Currently, bile excretion is explained by the osmotic model, according to which bile acids are excreted by hepatocytes into the bile canaliculi and since bile acids are osmotically active they draw water into the canalicular lumen. Bile canaliculi are closed at the central side. Therefore, bile was postulated to flow to the open side into the ducts. However, bile flow in canaliculi has never been measured because of the small canalicular diameter which does not allow analysis of flux by conventional methods. Recently, methods have been developed that allow flow analysis in bile canaliculi and ducts. Interestingly, no measurable directed flow was observed in the canaliculi. Instead, small molecules in bile canaliculi reached the larger bile ducts by diffusion. Only there measurable flow sets in. The pathophysiological implications of this novel observation are discussed.
description: EXCLI Journal; 19:Doc1208; ISSN 1611-2156
Modification of HER2 pre-mRNA alternative splicing and its effects on breast cancer cells
Creators: name: Kole, Ryszard
name: Sazani, Peter
name: Wan, Jing
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The oncogene HER2 is overexpressed in a variety of human tumors, providing a target for anti-cancer molecular therapies. Here we employed a 2’-O-methoxyethyl (MOE) splice switching oligonucleotide, SSO111, to induce skipping of exon 15 in HER2 pre-mRNA, leading to significant downregulation of full-length HER2 mRNA, and simultaneous upregulation of Δ15HER2 mRNA. SSO111 treatment of SK-BR-3 cells, which highly overexpress HER2, led to inhibition of cell proliferation and induction of apoptosis. The novel Δ15HER2 mRNA encodes a soluble, secreted form of the receptor. Treating SK-BR-3 cells with exogenous Δ15HER2 protein reduced membrane-bound HER2 and decreased HER3 transphosphorylation. Δ15HER2 protein thus has similar activity to an autoinhibitory, natural splice variant of HER2, Herstatin, and to the breast cancer drug Herceptin. Both SSO111 and Δ15HER2 may be potential candidates for the development of novel HER2-targeted cancer therapeutics.
Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosis
Creators: name: Zhou, Chunxiao
name: Boggess, John F.
name: Shafer, Aaron
name: Bae-Jump, Victoria L.
name: Gehrig, Paola A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: mTOR inhibitors modulate signaling pathways involved in cell cycle progression, and recent phase II trials demonstrate activity in endometrial cancer patients. Our objective was to examine the effects of combination therapy with rapamycin and paclitaxel in endometrial cancer cell lines. Paclitaxel inhibited proliferation in a dose-dependent manner in both cell lines with IC50 values of 0.1–0.5 nM and 1–5 nM for Ishikawa and ECC-1 cells, respectively. To assess synergy of paclitaxel and rapamycin, the combination index (CI) was calculated by the method of Chou and Talalay. Simultaneous exposure of cells to various doses of paclitaxel in combination with rapamycin (1 nM) resulted in a significant synergistic anti-proliferative effect (CI <1, range 0.131–0.920). Rapamycin alone did not induce apoptosis, but combined treatment with paclitaxel increased apoptosis over that of paclitaxel alone. Treatment with rapamycin and paclitaxel resulted in decreased phosphorylation of S6 and 4E-BP1, two critical downstream targets of the mTOR pathway. Rapamycin decreased hTERT mRNA expression by real-time RT-PCR while paclitaxel alone had no effect on telomerase activity. Paclitaxel increased polymerization and acetylation of tubulin, and rapamycin appeared to enhance this effect. Thus, in conclusion, we demonstrate that rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation, induction of apoptosis and potentially increased polymerization and acetylation of tubulin. This suggests that the combination of rapamycin and paclitaxel may be a promising effective targeted therapy for endometrial cancer.
The Impasse of Liberal (In)Equality: Materialising Egalitarian Politics Through Collective Fidelity
Creators: name: Parrouffe, Pierre
Publisher: name: University of Westminster
Year: 2020

description: This thesis is concerned with ways in which equality may be materialised through politics. It engages with various strands of literature that have had a profound impact on theoretical considerations of egalitarian politics. The thesis begins by mapping various branches of liberal egalitarianism that all set equality as a political objective. In attempting to substantiate equality through the liberal democratic nexus, these thinkers often construct their egalitarian models alongside liberal values such as individual liberty, autonomy, human rights, and market exchange. These approaches fall short of reconciling their egalitarian ambitions with the inegalitarian tendencies of market exchange, reducing equality to a question of inequalities in the process. Whereas contemporary neoliberal subjects embody the complete marketisation and individualisation of the liberal ideal of autonomy, hence foreclosing its egalitarian potential into purely heteronomous conducts, Jacques Rancière and Alain Badiou provide a way out of the impasse of liberal (in)equality. They do so by reconceptualising equality as a starting point rather than an objective of politics. Framed as such, egalitarian politics becomes a fully emancipatory project depending on the work of a subject for its realisation. Although Rancière’s egalitarianism is boundless, his account of subjectivation is politically limiting. Conversely, Badiou offers a methodical account of the process of ‘becoming subject’ rooted in his notions of ‘event’, ‘truth’, and ‘fidelity’. Focusing specifically on the latter, the last part of this thesis will theorise the notion of faith as a process for the materialisation of egalitarian politics. Against Badiou, political fidelity will be conceptualised as a subjective as well as an objective procedure. The object of political fidelity is the actual constitution of a collective. To the extent that theoretical subjects and truths play a crucial role in enacting egalitarian politics, existing bodies also actively participate in its material elaboration through a distinctive perspective provided by the horizontality of the existing ground, and their capacity to relate as equal through economic production, distribution, and exchange.
PREPARATION AND EVALUATION OF CONTROLLED RELEASE TABLETS CONTAINING IBUPROFEN
Creators: name: Takur Nagamalleshwari Bai*, Mr. Karingu Kiran
Publisher: name: Zenodo
Year: 2023

description: The present study aimed at Formulation Development and Evaluation of controlled release tablets of Ibuprofen is nonsteroidal anti-inflammatory drug (NSAID) class that is used for treating pain, fever, and inflammation. This includes painful menstrual periods, migraines, and rheumatoid arthritis. It may also be used to close a patent ductus arteriosus in a premature baby. It can be used by mouth or intravenously.
The matrix tablets of Ibuprofen were prepared using direct compression method. Physical characterization of tablet and powder blends used to form the matrix tablet was under taken using a range of experimental techniques. Granules were evaluated for Bulk density, Tapped density, Compressibility index and Hausner's ratio. Tablets were tested for weight variation, hardness, thickness and friability as per official procedure. The tablets were evaluated for in-vitro drug release profile. Dissolution studies of Ibuprofen controlled release tablets in media with different dissolution media 0.1N HCl, Phosphate buffer pH (6.8) as per US Pharmacopoeia.
The drug release from optimized formulations was controlled for a period of 12 hrs. The kinetic treatment of selected formulation (F3) showed that the release of drug follows Peppas release kinetics mechanism. Results of the present study indicated the suitability of different polymers in the preparation of matrix based controlled release formulation of Ibuprofen. Several kinetic models were applied to the dissolution profiles to determine the drug release kinetics.
Keywords: Ibuprofen, HPMC K 15M, HEC 2M, HPC 2M and Controlled release tablets.
title: Le fromage de petit lait chez les Aït Bouycef
Creators: name: Garaoun, Massinissa
Publisher: name: Pangloss
Year: 2023
Subjects: subject: Linguistique
subject: Tasahlit

description: Précisions dialectales : il s'agit du parler des Aït Bouycef (appelé dans la langue ṯaḇuysefṯ) appartenant à la fraction des Aït Ali Ou Jemaâ. Ce parler est classé parmi les variétés de la tasahlit occidentale
description: Préparation traditionelle du fromage de petit-lait chez les Aït Bouycef
Global stability of a time-delayed malaria model with standard incidence rate
Creators: name: Guo, Songbai
name: He, Min
name: Cui, Jing-An
Publisher: name: arXiv
Year: 2022
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 34K20, 37N25, 92D25

description: A four-dimensional delay differential equations (DDEs) model of malaria with standard incidence rate is proposed. By utilizing the limiting system of the model and Lyapunov direct method, the global stability of equilibria of the model is obtained with respect to the basic reproduction number ${R}_{0}$. Specifically, it shows that the disease-free equilibrium ${E}^{0}$ is globally asymptotically stable (GAS) for ${R}_{0}<1$, and globally attractive (GA) for ${R}_{0}=1$, while the endemic equilibrium $E^{\ast}$ is GAS and ${E}^{0}$ is unstable for ${R}_{0}>1$. Especially, to obtain the global stability of the equilibrium $E^{\ast}$ for $R_{0}>1$, the weak persistence of the model is proved by some analysis techniques.
Additional file 2 of Global analysis of switchgrass (Panicum virgatum L.) transcriptomes in response to interactive effects of drought and heat stresses
Creators: name: Hayford, Rita K.
name: Serba, Desalegn D.
name: Xie, Shaojun
name: Ayyappan, Vasudevan
name: Thimmapuram, Jyothi
name: Saha, Malay C.
name: Wu, Cathy H.
name: Kalavacharla, Venu Kal
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 2. Heat maps for the WGCNA modules: The heat map modules are in this order, module 1, module 2, module 3, module 5, module 7, module 8, module 9, module 14, module 15, module 16, module 17 and module 25.
Additional file 3 of Global analysis of switchgrass (Panicum virgatum L.) transcriptomes in response to interactive effects of drought and heat stresses
Creators: name: Hayford, Rita K.
name: Serba, Desalegn D.
name: Xie, Shaojun
name: Ayyappan, Vasudevan
name: Thimmapuram, Jyothi
name: Saha, Malay C.
name: Wu, Cathy H.
name: Kalavacharla, Venu Kal
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 3. Heat map of the 386 switchgrass genes that have best Arabidopsis hits in droughtDB.
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF CITICOLINE AND PIRACETAM IN BULK AND TABLET DOSAGE FORM BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Creators: name: Kanjarla Bhavani*, MRS. Bheemagoni Jyothi
Publisher: name: Zenodo
Year: 2023

description: Developed an accurate, precise and reproducible high performance liquid chromatographic method for simultaneous estimation of Citicoline and Piracetam in bulk and tablet dosage forms. Chromatographic separations of the drugs were achieved on a Symmetry ODS C18 (4.6×150mm, 5.0 µm) using a mobile phase consisting of Methanol: TEA Buffer pH-4.8 (35:65) v/v at a flow rate of 1.0 ml/min. The drugs elute were monitored at 276 nm. The retention time obtained for the Citicoline was 2.090 min and for the Piracetam was 5.289 min. The calibration curves were linear over the range of 20-60μg/ml and 25-75μg/ml for Citicoline and Piracetam respectively. The method is validated as per ICH guideline by determining its specificity, accuracy, precision, linearity & range, ruggedness, robustness and system suitability. The results of the study show that the proposed method is simple, rapid, precise and accurate, which is useful for the routine determination of Citicoline and Piracetam in bulk and tablet dosage forms. The method could be applied for determination of in its tablet dosage forms without any interference from excipients or endogenous substances. The proposed method is suitable for routine quality control analysis.
Keywords: Citicoline and Piracetam, RP-HPLC, Accuracy, ICH Guidelines.
Instrumental Processes Using Integrated Covariances
Creators: name: Mogensen, Søren Wengel
Publisher: name: arXiv
Year: 2022
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: Instrumental variable methods are often used for parameter estimation in the presence of confounding. They can also be applied in stochastic processes. Instrumental variable analysis exploits moment equations to obtain estimators for causal parameters. We show that in stochastic processes one can find such moment equations using an integrated covariance matrix. This provides new instrumental variable methods, instrumental variable methods in a class of continuous-time processes as well as a unified treatment of discrete- and continuous-time processes.
Telomere length, oxidative damage, antioxidants and breast cancer risk
Creators: name: Terry, Mary Beth
name: Shen, Jing
name: Teitelbaum, Susan L.
name: Wang, Qiao
name: Gammon, Marilie D.
name: Neugut, Alfred I.
name: Santella, Regina M.
name: Bradshaw, Patrick
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Telomeres play a critical role in maintaining the integrity and stability of the genome, and are susceptible to oxidative damage after telomere shortening to a critical length. In the present study, we explored the role of white blood cell (WBC) DNA telomere length on breast cancer risk, and examined whether urinary 15-F2-isoprostanes (15-F2t-IsoP) and 8-oxo-7,8-dihydrodeoxyguanosine (8-oxodG), or dietary antioxidant intake modified the relationship between telomere length and breast cancer risk. A population-based case-control study -- the Long Island Breast Cancer Study Project (LIBCSP) was conducted among 1,067 cases and 1,110 controls. Telomere length was assessed by quantitative PCR (Q-PCR). Overall, the mean levels of telomere length (T/S ratio), 15-F2t-IsoP and 8-oxodG were not significantly different between cases and controls. Among pre-menopausal women only, carrying shorter telomeres (Q3 and Q4), as compared with the longest (Q1), was associated with significantly increased breast cancer risk. Age-adjusted OR and 95%CI were 1.71 (1.10–2.67) and 1.61 (1.05–2.45). The 5-F2t-IsoP and 8-oxodG biomarkers did not modify the telomere-breast cancer association. A moderate increase in breast cancer risk was observed among women with the shortest telomeres (Q4) and lower dietary and supplemental intake of β-carotene, vitamin C or E intake (OR (95%CI)=1.48 (1.08–2.03), 1.39 (1.01–1.92) and 1.57 (1.14–2.18), respectively), although the trend test exhibited statistical significance only within the lower vitamin E intake subgroup (P trend =0.01). These results provided the strongest evidence to date that breast cancer risk may be affected by telomere length among pre-menopausal women or women with low dietary intake of antioxidants or antioxidant supplements.
Researching APEL routes to becoming professionally recognised as a teacher in Higher Education
Creators: name: Pokorny, Helen
Publisher: name: University of Westminster
Year: 2020

description: This study examines the experience of 19 academics who received postgraduate credits through an Assessment of Prior Experiential Learning (APEL) process with portfolios as the method of assessment. The purpose of the study was to inform the design of routes to professional recognition based on experience. Actor-Network-Theory (ANT) was used to analyse the data from the study which was in the form of interviews and portfolios. Key to ANT is the process of symmetry. That is, the principle that human and non-human elements of a network should be analysed in the same way. ANT provided an overarching framework for analysing different approaches to APEL whilst remaining true to the individual realities of the process for participants. ANT concepts such as mediators and intermediaries explained the different roles actors (human and material) had in shaping meaning and action in different networks. ANT facilitated an explanation of the role of evidence as both an enabler and barrier to the process of portfolio-building and made visible the resources used by participants in the process. Thus, ANT concepts were fundamental in explaining how the final portfolios came to be. The outcomes of the analysis provided an alternative to experiential learning models (cf Kolb) for facilitating APEL and hereafter the process is referred to as the Recognition of Prior Learning. Three approaches were identified to the translation and transfer of prior learning from practice contexts to academic contexts. These were Articulating, Demonstrating and Authenticating. These approaches represented as a model for Recognising Prior Learning (RPL) had different implications for individual subjectivities and behaviours. Developed into a typology of pedagogic approaches to RPL they provide ways of thinking about RPL design. The argument made throughout the study is that understanding the learner experience of RPL is key to increasing engagement with the process. Examples are provided from the author’s own practice which used the outcomes of this study to inform RPL design in the context of professional recognition and the award of academic credit.
Zur Begründung von Handlungszielen und Entscheidungskriterien
Creators: name: Oelmüller, Willi
Publisher: name: Herder Korrespondenz
Year: 1970

description: Herder Korrespondenz, Bd. 26 Nr. 2 (1972): Herder Korrespondenz, Band 26, Heft 2
title: Analysis and optimization of sustainable transport processes of biomass for power plants
Creators: name: Cienfuegos, Bernardo
Publisher: name: UNSPECIFIED
Year: 2020

description: This work addresses the transport planning of raw material supply chains for biomass power plants. It considers the need of generating sustainable solutions by analyzing relevant sustainability frameworks to propose a novel approach. It proposes a novel approach which consists of an architecture to tailor a proposed base model, and to process the relevant data needed to generate sustainable solutions. The special characteristics of the biomass transport problem and power plant requirements are captured in a formal problem definition in the form of a data model. The architecture consists of five combined models (called modules). Each module contributes with methods from different disciplines to enrich the solutions with distinct perspectives. The considered modules include elements from the social, weather, geographic information systems (GIS), life cycle impact assessment (LCIA), and mathematical optimization disciplines. An integrated solution is generated combining the results of all the modules. Important implementation elements for specific potential users are discussed to support a system prototype. A case study in Chile is used to gain related primary information of a real supply chain, test the architecture, and provide results about the performance, and allows a deeper discussion. The architecture generates optimized transport plans that make impacts visible in the considered sustainability dimensions and give the decision makers a better understanding of the effects of the considered solutions.