cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Combinations of ATR, Chk1 and Wee1 inhibitors with Olaparib are active in Olaparib resistant Brca1 proficient and deficient murine ovarian cells
Creators: name: Chiappa, Michela
name: Guffanti, Federica
name: Anselmi, Martina
name: Lupi, Monica
name: Panini, Nicolò
name: Wiesmüller, Lisa
name: Damia, Giovanna
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: ovarian carcinoma
subject: homologous recombination
subject: PARPi
subject: olaparib resistance
subject: DDC 610 / Medicine & health
subject: Ovarian neoplasms
subject: Ovarian neoplasms; Drug therapy
subject: Poly(ADP-ribose) polymerase inhibitors; Therapeutic use
subject: Eierstockkrebs
subject: ADP-Ribosyltransferasen

description: Simple Summary Poly(ADP-ribose) polymerases inhibitors (PARPis), including olaparib, have been recently approved for ovarian carcinoma treatment and PARPi resistance has already been observed in the clinics. With the aim of dissecting the molecular mechanisms of PARPi resistance, we generated olaparib resistant cells lines, both in a homologous recombination (HR)-deficient and -proficient background by continuous in vitro drug treatment. In the HR proficient background, olaparib resistance was caused by overexpression of multidrug resistance 1 gene (MDR1), while multiple heterogeneous co-existing mechanisms were found in olaparib resistant HR-deficient cells, including overexpression of MDR1, a decrease in PARP1 protein level and partial reactivation of HR repair. We found that combinations of ATR, Chk1 and Wee1 inhibitors with olaparib were synergistic in sensitive and resistant sublines, regardless of the HR status. These new olaparib resistant models will be instrumental to screen new therapeutic options for PARPi-resistant ovarian tumors. Abstract Background. Poly(ADP-ribose) polymerases inhibitor (PARPi) have shown clinical efficacy in ovarian carcinoma, especially in those harboring defects in homologous recombination (HR) repair, including BRCA1 and BRCA2 mutated tumors. There is increasing evidence however that PARPi resistance is common and develops through multiple mechanisms. Methods. ID8 F3 (HR proficient) and ID8 Brca1-/- (HR deficient) murine ovarian cells resistant to olaparib, a PARPi, were generated through stepwise drug concentrations in vitro. Both sensitive and resistant cells lines were pharmacologically characterized and the molecular mechanisms underlying olaparib resistance. Results. In ID8, cells with a HR proficient background, olaparib resistance was mainly caused by overexpression of multidrug resistance 1 gene (MDR1), while multiple heterogeneous co-existing mechanisms were found in ID8 Brca1-/- HR-deficient cells resistant to olaparib, including overexpression of MDR1, a decrease in PARP1 protein level and partial reactivation of HR repair. Importantly, combinations of ATR, Chk1 and Wee1 inhibitors with olaparib were synergistic in sensitive and resistant sublines, regardless of the HR cell status. Conclusion. Olaparib-resistant cell lines were generated and displayed multiple mechanisms of resistance, which will be instrumental in selecting new possible therapeutic options for PARPi-resistant ovarian tumors.
ADABIYOTSHUNOSLIKDA BADIIY ASAR TILI VA BADIIY NUTQ USLUBI
Creators: name: Qodirov, Abdulazizbek
name: Inomjonova, Mohlaroyim
name: Olimova, Xadichabonu
Publisher: name: Zenodo
Year: 2025

description: Ushbu maqolada badiiy asar tili va uslubi masalalari, badiiy nutq uslubi, asar tiliga munosabat, badiiy asarda syujetning yaratilishi, badiiy ifoda vositalari, asar tarkibidagi so’zlar hamda iboralar tasviri haqida bayon qilingan. Shu bilan bir qatorda, badiiy asar tilini ifodalashning o’ziga xos xususiyatlari hamda badiiy matnda tashqi tuyg’u va tasvirning ifodalanishi namoyon etilgan. Badiiy asar tlini o’rganishda muallif nutqi va personajlar nutqining o’zaro aloqadorligi badiiy nutq uslubiyatining markaziy muammolari tahlil qilingan.
Rapid Cross-Linking of Epoxy Thermosets Induced by Solvate Ionic Liquids
Creators: name: Hameed, Nishar
name: Eyckens, Daniel J.
name: Long, Benjamin M.
name: Salim, Nisa
name: Capricho, Jaworski
name: Servinis, Linden
name: De Souza, Mandy
name: Perus, Magenta D.
name: Varley, Russell J.
name: Henderson, Luke C.
Publisher: name: Swinburne
Year: 2024

description: The high-volume manufacture of fiber-reinforced composites faces a huge challenge because long resin curing times put a low ceiling on the total output of parts produced per year. To translate the benefits from using epoxy in large-volume production platforms, cure cycle times of less than 1 min must be achieved. In this work, we report solvate ionic liquids (SILs) as simple and efficient rapid curing catalytic additives in epoxy systems. Ultrafast curing was observed at low levels of 1-5% of SIL in epoxy resin, and the cure rate is enhanced up to 26-fold without compromising the mechanical and thermal properties. Further investigations revealed that enhancement in the cure rate is dependent on the type of SILs employed, influenced by the metal center, the ligands around the metal, and the identity of the counter anion. The relative Lewis acidity of each of the active complexes was calculated, and the rapid cure effect was attributed to the activation of the epoxide moietyviathe Lewis acidic nature of the SIL. Making epoxy thermosets rapidly processable enables enormous benefits, finding applications in a whole variety of transformation methods that exist for traditional glass and metals.
The roles of the retinoic acid receptors in growth, differentiation and development.
Creators: name: Costa, Stacy Lara.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Biology, Cell.

description: In the second chapter of this thesis I have looked at the roles of the retinoic acid receptors (RARs) in differentiation by assessing their actions in the retinoic acid (RA) induced differentiation of P19 cells. I used mutant RARs to block the normal differentiation of these cells and then analyzed the possible mechanisms by which these mutants are able to exert such effects. My results indicate that overexpression of a dominant negative RAR (RAR$\alpha$myc) is able to block the RA induced differentiation of P19 cells. I believe that RAR$\alpha$myc acts dominantly by sterically inhibiting the binding of normal transcription complexes to the retinoic acid response element. In the next part of my thesis, I wanted to assess the role of the RARs in tumourigenesis by overexpressing RAR$\alpha$myc in the mammary gland in the mouse. Many cancers arise due to a block in the normal differentiation of an undifferentiated precursor cell and I postulated that the RAR$\alpha$myc, because of its ability to block differentiation, would lead to tumourigenesis in the breast. This transgenic mouse model system has been used to assess the actions of a variety of oncogenes. Expression of my dominant negative RARa did not lead to tumourigenesis in the breast. However due to expression of the mutant RAR in the male reproductive tract these mice were infertile. My data suggests that the infertility arises due to a block in vas deferens caused by excessive production of seminal fluids. In the last part of this thesis I analyzed a novel mechanism by which I believe retinoids are able to integrate their growth signals with other growth signals within the cell. I found that E2F, a transcription factor which induces cell cycle progression, is able to specifically inhibit the actions of the RARs in activating transcription. My data indicates that this is due to E2F squelching of factors from RAR transcription complexes. My analysis suggests that a crucial co-activator which is required for RAR transactivation in P19 cells is being sequestered by E2F leading to the block in RAR transactivation. I believe that utilization of common co-activators by opposing growth signalling pathways is one way in which the cell is able to integrate growth signalling information.
Konsep Psikososial dalam Keperawatan
Creators: name: Dias, Maria Frani Ayu Andari
Publisher: name: Zenodo
Year: 2020
Subjects: Konsep psikososial dalam keperawatan
Psikososial dalam Keperawatan
Psikososial

description: Konsep Psikososial dalam Keperawatan, terbagi menjadi beberapa konsep penting yaitu, 1) Konser Diri, 2) Kesehatan Spiritual, 3) Konser Seksualitas, 4) Konser Stress-Adaptasi dan 5) Konsep Kehilangan. Bahan ini disiapkan untuk bahan belajar mahasiswa/i Keperawatan dan untuk kepentingan belajar semata. Salam.
The concept of world hegemony and the understanding of international cooperation and regulation: A critical reading of the current conceptualizations of world hegemony.
Creators: name: Choukri, Ezz-Edine.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Political Science, International Law and Relations.

description: This thesis questions the utility of the concept of "world hegemony" in understanding world politics. In doing so, it reviews the ways in which both Realist and Marxist traditions used that concept to study three examples of international regulation: the GATT, the global environmental negotiations, and the Coordinated Aid to Russia. This review shows the limited explanatory power of both Realist and Marxist conceptions of hegemony. Based on the analysis of modernity presented by Karl Polanyi and Anthony Giddens, the thesis presents a new conception of world hegemony that refers to the centuries-long build-up of consensus and consent around a modern and global historic bloc. The latter includes market-economy, interstate system, individualism and human emancipation. The analysis of the interactions between actors and this multidimensional global historic bloc provides better understanding of the three examples of international regulation used in the thesis.
Regulations for the protection against noise from wind turbines in Germany
Creators: name: Bauerdorff, Andrea
Publisher: name: My University
Year: 2019
Subjects: Windenergieanlage
Betriebsvorschrift
Lärmimmission
Schallausbreitung
Bewertung

description: The generation of energy by wind turbines is essential for the implementation of the energy transition. Especially in Germany, the number of wind turbine installations has continuously increased over the last years. In 2018, there were 29213 wind turbines with an installed wind power capacity of 52931 MW [1]. Within the framework of the importance of wind energy, the protection of the population from wind turbine noise has to be taken into consideration. The legal basis are the German Federal Immission Control Act and the "Technical Instructions on Noise Abatement, TI Noise". The TI Noise deals with the determination and the assessment of noise generated from industrial and commercial installations, including wind turbines. Especially, it contains ambitious binding immission values for immission points outside buildings. These regulations will be explained in detail. Moreover, the low-frequency noise immission of wind turbines will be discussed and evaluated. In: Saschita ot powyschennogo schuma i wibrazii / Sbornik dokladow Pod redakziej N.I. Iwanowa. - Sankt-Peterburg - (2019), Seite 15
The Space Atom Interferometer project: status and prospects
Creators: name: Sorrentino, Francesco
name: Bongs, Kay
name: Bouyer, Philippe
name: Cacciapuoti, Luigi
name: Angelis, M.
name: Dittus, Hansjörg
name: Ertmer, Wolfgang
name: Hartwig, Jonas
name: Hauth, Michael
name: Herrmann, Sven
name: Huang, Kun
name: Inguscio, Massimo
name: Kajari, Endre
name: Könemann, T.
name: Lämmerzahl, Claus
name: Landragin, A.
name: Modugno, G.
name: Santos, F. Pereira
name: Peters, A.
name: Prevedelli, M.
name: Rasel, Ernst Maria
name: Schleich, Wolfgang P.
name: Schmidt, M.
name: Senger, A.
name: Sengstock, Klaus
name: Stern, G.
name: Tino, G. M.
name: Valenzuela, T.
name: Walser, Reinhold
name: Windpassinger, P.
Publisher: name: Universität Ulm
Year: 2011
Subjects: subject: Space Atom Interferometer project (SAI)
subject: DDC 520 / Astronomy
subject: DDC 530 / Physics
subject: Reduced gravity environments
subject: Interferometry
subject: Acceleration (Mechanics)
subject: Research in reduced gravity environments
subject: Interferometer
subject: Beschleunigung
subject: Mikrogravitation

description: This paper presents the current status and future prospects of the Space Atom Interferometer project (SAI), funded by the European Space Agency. Atom interferometry provides extremely sensitive and accurate tools for the measurement of inertial forces. Operation of atom interferometers in microgravity is expected to enhance the performance of such sensors. Main goal of SAI is to demonstrate the possibility of placing atom interferometers in space. The resulting drop-tower compatible atom interferometry acceleration sensor prototype is described. Expected performance limits and potential scientific applications in a micro-gravity environment are also discussed.
title: Die Anwendung von gepaarter phasengebundener transkranieller elektrischer Stimulation zur Induktion assoziativer interhemisphärischer Plastizität
Creators: name: Naros, Andreas
Publisher: name: Universität Tübingen
Year: 2025
Subjects: subject: 610

description: In den Neurowissenschaften besteht ein wachsendes Interesse an beidseitiger transkranieller elektrischer Stimulation zur Erforschung und Modulation oszillierender Interaktion zwischen zwei Zielgebieten. In-Phase (Δφ = 0) und anti-phasische (Δφ = π) Stimulationsprotokolle wirken synchronisierend beziehungsweise desynchronisierend auf die interregionale Kommunikation. Demgegenüber gibt es bisher nur wenige Erkenntnisse über die Effekte phasenverschobener Stimulationsprotokolle (z.B. Δφ = π/2). Daher sollten in der vorliegenden Dissertation die kortikospinalen und kortikokortikalen Effekte unterschiedlicher phasenverschobener Stimulationsprotokolle untersucht werden. Im experimentellen Ablauf verwendeten wir hierfür eine beidseitige, oszillierende transkranielle Gleichstromstimulation (ds-toDCS = dual-site transcranial oscillating current stimulation) mit den Phasenkodierungen Δφ = 0, Δφ = π und Δφ = π/2 auf den bilateralen motorischen M1-Arealen an 10 gesunden Probanden. Untersucht wurde an unterschiedlichen Studientagen mit randomisierter Abfolge der Stimulationsprotokolle. Erhoben wurden als behaviorales Maß die motorische Performance am Purdue Pegboard Test sowie die kortikalen neurophysiologischen Effekte durch transkranielle Magnetstimulation (TMS) und Elektroenzephalographie (EEG). Die erhobenen Werte wurde mit einer einseitigen Stimulation (ss-toDCS) verglichen. Unsere Ergebnisse zeigten für keine Gruppe Veränderungen der kortikospinalen Exzitabilität im TMS-Mapping. Entgegen der ursprünglichen Annahme einer Verstärkung der interhemisphärischen Interaktion bei Stimulation ohne Phasenverschiebung (Δφ = 0) sowie einer Schwächung bei anti-phasischer Stimulation (Δφ = π), lieferten die kortico-korticalen TMS-evozierten Potentiale (CCEPs) bei der phasenverschobenen ds-toDCS Stimulation (Δφ = π/2) Hinweise auf eine Modulation der interhemisphärischen Kommunikation über einen Zeitraum von 20 Minuten hinweg. Diese Veränderung der kortikalen Physiologie wurde von einer signifikanten Verbesserung der motorischen Performance in der kontralateralen Hand begleitet. Aus diesen Ergebnissen schlussfolgern wir, dass im Gegensatz zur in-Phase (Δφ = 0) und anti-phasischen (Δφ = π) Stimulation, die phasenverschobene (Δφ = π/2) ds-toDCS Stimulation über das Potential verfügt die interregionale Kommunikation zu modifizieren, ein Effekt, den wir uns durch die Zeitkonstante der NMDA-Rezeptoren erklären. Wir nehmen dabei an, dass die stimulationsbedingte stochastische Paarung der synaptischen Aktivität in LTP-ähnlicher assoziativer Plastizität resultiert.
Pour quelques rêves de plus.
Creators: name: Duhaime, André.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Literature, Romance.

description: Comme l'attestent les nombreuses publications traitant du reve, aussi bien d'ailleurs les ouvrages "savants" que "populaires", le mot "reve" et ses multiples connotations peuvent nous entrai ner sur de nombreuses pistes. Pour eviter toute confusion, il convient de preciser le sens que je lui confere. Ainsi, ce qui m'interesse, c'est uniquement le reve en tant que source de creation litteraire; ce sont les images qui surgissent durant mes reves et que je transcris sous torme de recits de reves. Ce qui signifie que mon travail sur le reve ne constitue ni une technique de croissance personnelle, ni une demarche therapeutique, ni une experience mystique. De plus, je ne cherche pas a rendre compte de la nature, de la fonction ou de la signification des reves, ni des differences ou des similitudes entre l'activite onirique et l'activite vigile. La premiere partie de cette these en creation litteraire propose un ensemble de textes presentes sous la forme de proses breves qui temoignent de mes reves nocturnes. La deuxieme partie constitue un parcours reflexif lie a la redaction des textes de creation. D'une part, celui-ci se nourrira de certains recueils de recits de reves d'ecrivains chacun de ces auteurs me permettant de mieux circonscrire les enjeux inherents a mon entreprise. D'autre part, ces enjeux, multiples, convergent vers l'approfondissement d'un certain nombre d'interrogations reparties en quatre chapitres: premierement, je presenterai l'origine de mon interet pour les recits de reves, puis j'examinerai la notion "journal de reves"; deuxiemement, j'analyserai mes recits en tenant compte de certains parametres: la prose, le style et le temps; troisiemement, je proposerai une "petite esquisse psychanalytique" de mes textes. (Abstract shortened by UMI.)
Assessment of the potential association between glutathione S-transferase polymorphisms and colorectal cancer: A systematic review, meta- and pooled analysis
Creators: name: Hutchings, Kimberley
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Health Sciences, Oncology.

description: Background. Colorectal cancer is the second leading cause of death from cancer in Canada. Many studies have examined associations between GSTM1, GSTT1, and GSTP1 polymorphisms and colorectal cancer but with conflicting results. The objective of this study was to examine the totality of evidence for association between these polymorphisms and risk for colorectal cancer or adenoma. Methods. A systematic review, meta- and pooled analysis were conducted. Results. The meta- and pooled analysis suggest weak significant associations between GSTM1 (ORpooled=1.11; 95%CI: 1.02,1.23), GSTT1 (ORpooled=1.22; 95%CI: 1.10,1.35), and with presence of null variants of each and colorectal cancer, but with heterogeneity between studies. No association between GSTP1 and colorectal cancer, or between any of the polymorphisms and colorectal adenoma, was observed. Significant multiplicative GST gene-gene interactions or gene-environment (smoking) interaction effects were not observed. Conclusion. Evidence to date shows weak associations between GSTM1 and GSTT1 and colorectal cancer.
WoSP: a multi-optima particle swarm algorithm
Creators: name: Hendtlass, Tim
Publisher: name: Swinburne
Year: 2024

description: When investigating multi-optima problems, a particle swarm algorithm should not converge on single optima but ideally should explore many optima by continual searching. The common practice of only evaluating each particle's performance at discrete intervals can, at small computational cost, be used to adjust particle behaviour in situations where the swarm is 'settling' so as to encourage the swarm to explore further. An algorithm is proposed that, by making each wave of particles partially independent, is suitable for multi-optima problems.
Supplementary document for Observing exceptional point degeneracy of radiation with electrically pumped photonic crystal coupled-nanocavity lasers - 5004228.pdf
Creators: name: Takata, Kenta
name: Nozaki, Kengo
name: Kuramochi, Eiichi
name: Matsuo, Shinji
name: Takeda, Koji
name: Fujii, Takuro
name: Kita, Shota
name: Shinya, Akihiko
name: Notomi, Masaya
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: This supplemental document (Supplement 1) shows and disscusses our method details, and additional experimental data and theoretical analyses that support the main results presented in our manuscript.
The purification, characterization and mode of action of Bacillus thuringiensis subspecies israelensis proteins.
Creators: name: Huang, Fang.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Biology, Microbiology.

description: The gram-positive, spore forming bacteria Bacillus thuringiensis synthesize cytoplasmic crystalline inclusions, the Bt proteins, which are toxic to insect larvae. Although Bt proteins have been used as bioinsecticides for many years and a considerable number of studies have been carried out to investigate their mode of action, their precise mechanism of action still remains unclear. A 27 kDa protein from Bt subsp. israelensis (cytA27) is known for its broad cytolytic activity against a wide range of invertebrate and vertebrate cells in vitro as well as mosquitocidal activity in vivo. Given the interest in the mechanism of the membrane interaction of cytA27 and its proteolytic product, a 24 kDa protein (cytA24), we have undertaken a study of their interactions with model phospholipid membranes. The cytA27 and cytA24 proteins were purified by selective solubilization and ion exchange HPLC and characterized by SDS-PAGE, N-terminal sequencing and mass spectrometry. Fluorescence spectroscopy was used to characterize the cytA-induced release of fluorescence markers from vesicles and the cytA-vesicle affinity and stoichiometry. The results indicate that cytA proteins bind to lipids and affect the integrity of phospholipid vesicles. The binding is non-specific in that it does not require a receptor. CytA27 and cy8tA24 interact with PC-LUV with apparent binding constants of $\rm (0.34\pm0.02)\times10\sp5M\sp{-1}$ and $\rm (1.54\pm0.10)\times10\sp5M\sp{-1}$ respectively. Binding isotherm data indicate that a critical number of cytA molecules must associate with the membrane in order to induce vesicle leakage. Approximately 324 of cytA27 and 157 of cytA24 molecules are required to bind to one PC-LUV before the latter starts to release its contents. CytA-induced vesicle leakage follows an all-or-none mechanism, i.e. each LUV either releases all of its contents or remains intact. (Abstract shortened by UMI.)
title: Die Debatte um Klimawandel und Gesundheit im Deutschen Ärzteblatt von 1973 bis 2020 und die Rolle der Medizinethik
Creators: name: Wild, Nathan Martin
Publisher: name: Universität Tübingen
Year: 2025
Subjects: subject: Klimaänderung , Medizinische Ethik , Gesundheit , Medizingeschichte , Planetare Gesundheit , Klimaschutz , Krankenhaus
subject: 610
subject: Klimawandel und Gesundheit
subject: Deutsches Ärzteblatt
subject: Planetary Health Ethik

description: Die vorliegende Dissertation untersucht die Debatte um Klimawandel und Gesundheit im Deutschen Ärzteblatt von 1973 bis 2020 und widmet sich insbesondere der Rolle der Medizinethik. Es wurden 261 Publikationen quantitativ und qualitativ auf formale Kriterien und inhaltliche Argumente hin untersucht. Wesentliche Inhalte des Ergebnisteils und der Diskussion sind unter anderem: Anstieg der Publikationszahlen im untersuchten Zeitraum, Nachweis weniger AutorInnen, Ursprung der Debatte um Klimawandel und Gesundheit in der Debatte um Umweltschutz und Umweltmedizin, medizinische Argumentation für Klimaschutz im Gesundheitssektor über Klimaschutz als Primärprophylaxe, besondere Verantwortung für sogenannte Entwicklungsländer, Klimaschutz im Krankenhaus ökonomisch sinnvoll, kein spezifisch medizinethischer Beitrag, keine Thematisierung von Zielkonflikten, Extraktion von medizinethischen Themen aus Nebensätzen. Medizinische Themen: Politisierung des Arztberufes durch Klimaschutz, Stärkung der Gesundheitsprävention durch Klimawandeldebatte, Beziehung von Klimaschutz auf ärztliche Grundorientierungen, medizinethische Fragen der Klima-Triage und der Generationengerechtigkeit.
Umweltwirkungen einer innerörtlichen Regelgeschwindigkeit von 30 km/h
Creators: name: Heinrichs, Eckhart
name: Klein, Timotheus
name: Blohm, Juliane
Publisher: name: Umweltbundesamt
Year: 2023
Subjects: subject: Geschwindigkeitsbeschränkung
subject: Lärm
subject: Verkehrssicherheit
subject: Tempo 30
subject: 30 km/h
subject: Zulässige Höchstgeschwindigkeit
subject: innerorts
subject: Tempolimit
subject: Luftschadstoffe
subject: Luft
subject: Verkehr
subject: Lärm

description: Das vorliegende Forschungsvorhaben untersucht die möglichen Auswirkungen einer innerörtlichen Regelgeschwindigkeit von 30 km/h auf Verkehr, Lärm- und Luftschadstoffbelastung. Grundlage der Untersuchung sind Simulationen in den Modellstädten Halle, Göttingen und Ravensburg. Das Vorhaben soll Erkenntnisse liefern, die bei einer modellhaften Erprobung oder auch bei einer generellen Einführung von Tempo 30 innerorts berücksichtigt werden können. Im Ergebnis liegen Erkenntnisse zu möglichen verkehrlichen und Umweltwirkungen vor sowie Empfehlungen zur Einführung von Tempo 30 als innerörtliche Regelgeschwindigkeit mit Hin weisen zu Begleituntersuchungen bei einer Umsetzung. Quelle: Forschungsbericht
description: This research project explores the possible impact of a 30 km/h speed limit in urban areas on traffic as well as on noise and air pollution. The study is based on simulations in the model cities of Halle, Göttingen and Ravensburg. The project is intended to generate findings that can be taken into account in a representative trial or in a general rollout of 30 km/h speed limit in built up urban areas. At the end of the project, findings pertaining to the possible impact on traffic and the environment, recommendations on the rollout of a 30 km/h speed limit in urban areas as well as information on accompanying studies will be available for use in the implementation phase. Quelle: Forschungsbericht
description: Das Umweltbundesamt hat die Wirkungen von Tempo 30 als innerörtliche Regelgeschwindigkeit auf Verkehr, Lärm und Luftschadstoffe erforschen lassen. Grundlage waren Verkehrssimulationen in den Beispielstädten Göttingen, Halle/Saale und Ravensburg. Die Simulationen fußen auf der Annahme, dass Tempo 30 generell am Ortseingangsschild gilt, an wenigen geeigneten Hauptverkehrsstraßen aber ausnahmsweise höhere Geschwindigkeiten zugelassen sind. Mithilfe von Emissions- und Schallausbreitungsmodellen wurden daraus die Umweltwirkungen abgeleitet. Auch Auswirkungen auf den ⁠Umweltverbund⁠ im Nahverkehr und auf die Verkehrssicherheit wurden betrachtet.
Development of a combined carrier test for a disinfectant efficacy.
Creators: name: Best, Maureen.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Biology, Microbiology.

description: There is mounting concern on the efficacy of many germicides on the market because officially recognized germicidal tests for various classes of microorganisms vary widely and lack reproducibility and proper quantitation. This project outlines a novel carrier method for simultaneously and quantitatively assessing the efficacy of liquid chemical germicides against a mixture of microorganisms of varying degrees of resistance. In the test, glass cups were contaminated with 10 $\mu$l of a standardized mixture of Staphylococcus aureus, Mycobacterium bovis BCG, Trichophyton mentagrophytes spores, Sabin poliovirus type 1 and Bacillus stearothermophilus spores in 5% fetal bovine serum. The inoculum was dried for 60 min at room temperature (22 $\pm$ 2$\sp\circ$C), covered with 60 $\mu$l of the disinfectant under test or a balanced salt solution for the desired contact time. The carrier was then placed in 2,940 $\mu$l of an eluent and eluates assayed separately for the five microorganisms. The findings demonstrate the feasibility of a novel approach to the testing of chemical germicides. The combined carrier test allows for concurrent evaluation of efficacy claims and demonstrates the resistance patterns of various classes of microorganisms. This method also permits a more reliable means of classifying germicides based on their spectrum of activity. (Abstract shortened by UMI.)
Sieving of spherical particles during gel electrophoresis: A new computer simulation algorithm.
Creators: name: Guo, Hong L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Chemistry, Physical.

description: A new computer simulation algorithm is developed to study the behavior of a hard sphere during gel electrophoresis. The electrophoresis mobility and the diffusion coefficients are presented to show the effects of the field intensity, of the gel concentration, and of the randomness of the gel. The results indicate that previous models are not applicable for either the periodic or the random gel, and that the Einstein relation does not hold because the gel molecules affect the dynamics of the hard sphere. Moreover, the randomness of sieving gels lead to a trapping effect where the longitudinal diffusion coefficient is much larger than expected when the gel is dense and the field intensity is non-negligible. This trapping effect predicts a limit to both the field intensity and the gel concentration that one can use for the separation of particles during gel electrophoresis. Our new algorithm thus opens a door to a detailed study of the process of electrophoretic sieving with potential applications in biology and biotechnology.
Supplementary document for Observing exceptional point degeneracy of radiation with electrically pumped photonic crystal coupled-nanocavity lasers - 5004228.pdf
Creators: name: Takata, Kenta
name: Nozaki, Kengo
name: Kuramochi, Eiichi
name: Matsuo, Shinji
name: Takeda, Koji
name: Fujii, Takuro
name: Kita, Shota
name: Shinya, Akihiko
name: Notomi, Masaya
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: This supplemental document (Supplement 1) shows and disscusses our method details, and additional experimental data and theoretical analyses that support the main results presented in our manuscript.
Association of thigh muscle strength with texture features based on proton density fat fraction maps derived from chemical shift encoding-based water−fat MRI
Creators: name: Dieckmeyer, Michael
name: Inhuber, Stephanie
name: Schläger, Sarah
name: Weidlich, Dominik
name: Mookiah, Muthu R. K.
name: Subburaj, Karupppasamy
name: Burian, Egon
name: Sollmann, Nico
name: Kirschke, Jan S.
name: Karampinos, Dimitrios C.
name: Baum, Thomas
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: texture analysis
subject: proton density fat fraction
subject: thigh muscles
subject: DDC 610 / Medicine & health
subject: Magnetic Resonance Imaging
subject: Thigh
subject: Muscle Strength
subject: Kernspintomografie
subject: Muskeltraining

description: Purpose: Based on conventional and quantitative magnetic resonance imaging (MRI), texture analysis (TA) has shown encouraging results as a biomarker for tissue structure. Chemical shift encoding-based water–fat MRI (CSE-MRI)-derived proton density fat fraction (PDFF) of thigh muscles has been associated with musculoskeletal, metabolic, and neuromuscular disorders and was demonstrated to predict muscle strength. The purpose of this study was to investigate PDFF-based TA of thigh muscles as a predictor of thigh muscle strength in comparison to mean PDFF. Methods: 30 healthy subjects (age = 30 ± 6 years; 15 females) underwent CSE-MRI of the lumbar spine at 3T, using a six-echo 3D spoiled gradient echo sequence. Quadriceps (EXT) and ischiocrural (FLEX) muscles were segmented to extract mean PDFF and texture features. Muscle flexion and extension strength were measured with an isokinetic dynamometer. Results: Of the eleven extracted texture features, Variance(global) showed the highest significant correlation with extension strength (p < 0.001, R2adj = 0.712), and Correlation showed the highest significant correlation with flexion strength (p = 0.016, R2adj = 0.658). Multivariate linear regression models identified Variance(global) and sex, but not PDFF, as significant predictors of extension strength (R2adj = 0.709; p < 0.001), while mean PDFF, sex, and BMI, but none of the texture features, were identified as significant predictors of flexion strength (R2adj = 0.674; p < 0.001). Conclusions: Prediction of quadriceps muscle strength can be improved beyond mean PDFF by means of TA, indicating the capability to quantify muscular fat infiltration patterns.
Identifying gaps for research prioritisation: Global burden of external causes of injury as reflected in the Cochrane Database of Systematic Reviews
Creators: name: Karimkhani, Chante
name: Trikha, Ritika
name: Aksut, Baran
name: Jones, Trevor
name: Boyers, Lindsay N.
name: Schlichte, Megan
name: Pederson, Hannah
name: Okland, Tyler
name: Diguiseppi, Carolyn
name: Nasser, Mona
name: Naghavi, Mohsen
name: Vos, Theo
name: Yoong, Serene
name: Wolfenden, Luke
name: Murray, Christopher J.L.
name: Dellavalle, Robert P.
Publisher: name: Swinburne
Year: 2024

description: Importance Burden of disease should impact research prioritisation. Objective: To analyse the Cochrane Database of Systematic Reviews (CDSR) and determine whether systematic reviews and protocols accurately represent disease burden, as measured by disability-adjusted life years (DALYs) from the Global Burden of Disease (GBD) 2010 Study. Methods: Two investigators collected GBD disability metrics for 12 external causes of injury in the GBD 2010 Study. These external causes were then assessed for systematic review and protocol representation in CDSR. Data was collected during the month of April 2015. There were no study participants aside from the researchers. Percentage of total 2010 DALYs, 2010 DALY rank, and median DALY percent change from 1990 to 2010 of the 12 external causes of injury were compared with CDSR representation of systematic reviews and protocols. Data were analysed for correlation using Spearman rank correlation. Results: Eleven of the 12 causes were represented by at least one systematic review or protocol in CDSR; the category collective violence and legal intervention had no representation in CDSR. Correlation testing revealed a strong positive correlation that was statistically significant. Representation of road injury; interpersonal violence; fire, heat, and hot substances; mechanical forces; poisonings, adverse effect of medical treatment, and animal contact was well aligned with respect to DALY. Representation of falls was greater compared to DALY, while self-harm, exposure to forces of nature, and other transport injury representation was lower compared to DALY. Conclusions and relevance CDSR representation of external causes of injury strongly correlates with disease burden. The number of systematic reviews and protocols was well aligned for seven out of 12 causes of injury. These results provide high-quality and transparent data that may guide future prioritisation decisions.
A preliminary study of entrepreneurial family businesses in New Zealand, and some implications for growth
Creators: name: Woods, Christine
name: Shepherd, Deb
name: Irving, David
name: Dale, Claire
Publisher: name: Swinburne
Year: 2024

description: Family Business was rediscovered as a global phenomenon in the 1980s, about 10 years after researchers had rediscovered that, internationally, small and medium-sized businesses make a significant contribution to output, and to employment. In much of the traditional literature, Family Business is negatively stereotyped either in a 'mom and pop' model, as the corner store business, incapable of significant growth; or in a 'patriarchal' model, hierarchical, dominated by the founder, and resistant to change. In the orthodox economic model of the firm, the family firm is merely one stage in the life of the enterprise, following the start-up period and preceding the public company phase. In all of these, the Family Business is a limited and limiting model. The new academic field of Family Business was given coherence and direction by Sharma (2004). Although research on Family Business in New Zealand is sparse, it appears that here, too, many large and small businesses are family businesses. Also, interestingly, despite constraining stereotypes, and although they would meet only the loosest criteria, some very successful New Zealand CEOs choose to identify their enterprises as family businesses, indicating that Family Business has positive connotations in New Zealand. It would be useful to investigate the prevalence of entrepreneurial Family Businesses in New Zealand. It would also be useful to explore the various definitions of Family Business, giving particular attention to attribution of positive and negative characteristics.
title: Human Centered Design - Does anybody (take) care?
Creators: name: Stein, Elisabeth
name: Burmester, Michael
Publisher: name: Gesellschaft für Informatik e.V.
Year: 2020
Subjects: subject: Human Centered Design
subject: KMU
subject: Verantwortung

description: Die menschzentrierte Ausrichtung von kleinen und mittleren Unternehmen führt dazu, dass diese wirtschaftlich erfolgreich, an den Bedürfnissen der Menschen orientiert und somit langfristig innovativ sein können. Mit dem Konzept einer Verantwortlichkeit, welche die Menschzentrierung sicherstellt und gestaltet, kann ein konkretes Handlungsinstrument zur Umsetzung geschaffen werden. Mithilfe von qualitativen Interviews wurden Entscheidungstragende aus kleinen und mittleren Unternehmen zur Akzeptanz eines solchen Konzepts befragt sowie Chancen und Herausforderungen diskutiert. Dabei zeigt sich, dass die grundsätzliche Akzeptanz einer Verantwortungsübernahme für die Menschzentrierung gegeben ist. Identifizierte Herausforderungen sind folgende Themenbereiche: Change Management, Mehrwert der Menschzentrierten Gestaltung, Unternehmenskultur, Organisationsstruktur und Ressourcenmangel. Zudem wurden erste Anforderungen an das Profil eines Human-Centered-Design-Verantwortlichen für die Menschzentrierung formuliert.
Substitutionsquote
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2019
Subjects: subject: Kreislaufwirtschaft
subject: Monitoring
subject: Ressourcenverbrauch
subject: Wiederverwendung
subject: Rohstoffe
subject: Substitutionsquote
subject: Wiedernutzung
subject: Abfall | Ressourcen

description: Die Industriegesellschaft hat jahrzehntelang unseren Wohlstand gesichert. Zugleich sind der Ressourcen- und Energieverbrauch sowie die Treibhausgasemissionen stark gestiegen. Es gilt mehr denn je, unseren Wohlstand vom Ressourcenverbrauch zu entkoppeln. Das erfordert die sparsame Verwendung von Ressourcen und lange Nutzung sowie die Wieder- und Weiternutzung von Rohstoffen, die sich bereits in der Nutzung befinden. Vor dem Hintergrund der Endlichkeit der genutzten Rohstoffe ist eine Wiedernutzung von bereits in der Wirtschaft befindlichen Stoffen zwingend erforderlich. Um den Erfolg der Kreislaufwirtschaft realistisch messen zu können, empfiehlt die Ressourcenkommission am Umweltbundesamt (KRU) die Einführung einer Substitutionsquote. Quelle: Bericht
description: Die Industriegesellschaft hat jahrzehntelang unseren Wohlstand gesichert. Zugleich sind der Ressourcen- und Energieverbrauch sowie die Treibhausgasemissionen stark gestiegen. Es gilt mehr denn je, unseren Wohlstand vom Ressourcenverbrauch zu entkoppeln. Das erfordert die sparsame Verwendung von Ressourcen und lange Nutzung sowie die Wieder- und Weiternutzung von Rohstoffen, die sich bereits in der Nutzung befinden. Vor dem Hintergrund der Endlichkeit der genutzten Rohstoffe ist eine Wiedernutzung von bereits in der Wirtschaft befindlichen Stoffen zwingend erforderlich. Um den Erfolg der Kreislaufwirtschaft realistisch messen zu können, empfiehlt die Ressourcenkommission am Umweltbundesamt (KRU) die Einführung einer Substitutionsquote.
title: Maßnahmen zur Steigerung der organisationalen UX-Kompetenz
Creators: name: Winter, Dominique
Publisher: name: Gesellschaft für Informatik e.V.
Year: 2020
Subjects: subject: User Experience
subject: Kompetenz
subject: Organisation
subject: Organisationsentwicklung

description: Usability und User Experience (UX) haben als Design-Aspekte in der Produktentwicklung zunehmend an Bedeutung gewonnen. Daher ist es sinnvoll, die organisationale Kompetenz zur Ent-wicklung von Produkten mit einer positiven UX zu stärken. Ver-änderungen in Organisationen sind jedoch mit großem Aufwand verbunden. Deshalb müssen Organisationen entscheiden, welche Aktivitäten zur Veränderung der eigenen Kompetenz durchge-führt werden sollen und welche nicht. Die bisherige Forschung hat sich weitgehend auf die Anwendbarkeit bestimmter Metho-den im Projekt- und Produktkontext konzentriert. Um geeignete Aktivitäten zur Verbesserung der organisationalen UX-Kompetenz zu identifizieren, wurden 17 UX-Professionals be-fragt. Diese UX-Professionals haben mindestens zehn Jahre Er-fahrung durch die Arbeit in mehreren Unternehmen und durch die Übernahme einer Führungsrolle im Bereich UX gesammelt. Aus diesen Interviews wurden 13 mögliche Maßnahmen zur Steigerung der UX-Kompetenz von Organisationen abgeleitet. Dazu gehören beispielsweise die Erhöhung der Kompetenz ein-zelner Mitarbeiter, das Teilen von UX-Erfolgsgeschichten oder das Ermöglichen von User Research.
Developing self-efficacy and entrepreneurial intent for technology entrepreneurship: the role of work experience
Creators: name: Cooper, Sarah Y.
name: Ward, Tony
name: Lucas, William A.
name: Cave, Frank
Publisher: name: Swinburne
Year: 2024

description: Decline in traditional sectors has seen attention paid by governments to encouraging the development of new-technology-based sectors which exploit advances in fields such as electronics, biotechnology and software. Wealth and employment creation in these areas has been fuelled by the emergence and growth of innovative small and medium-sized enterprises (SMEs). The emergence and growth of new sectors is inextricably linked with entrepreneurship since the founder is the key driver in the venture creation process. Research on new technology-based firm founders points to the importance of education, previous work experience and personal motivation in influencing the ventures they create. For sectoral growth to occur calls not only for a flow of would-be entrepreneurs but also a supply of innovative and capable employees to help existing firms maintain their competitive edge. To help underpin economic development the United Kingdom (UK) government has supported university-based initiatives targeted particularly at raising understanding of enterprise among science, engineering and technology (SET) students and enabling them to develop skills and competence suited to employment within SMEs and large organisations. Whilst university students derive much education and learning from within their principal discipline, significant learning occurs outside the 'classroom' at home, in social settings and the workplace. This view focuses attention on colleges and universities to produce graduates in SET-oriented disciplines who are capable of filling these roles, but education is best considered in a broader context. Course of study, entrepreneurship, business education and industrial work experience operate together to shape self-efficacy and entrepreneurial intention. The research draws upon a number of theoretical concepts to explore influences on the motivation and capability of graduates to engage in entrepreneurial behaviour.
Apgar Score and Neurodevelopmental Outcomes at Age 5 Years
Creators: name: Harald, Erhardt
name: Aubert, Adrien M.
name: Ådén, Ulrika
name: Varendi, Heili
name: Weber, Tom
name: Zemlin, Michael
name: Maier, Rolf F.
name: Zeitlin, Jennifer
name: EPICE-SHIPS Research Group
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Perinatal Intensive Care
subject: Newborn infants
subject: DDC 610 / Medicine & health
subject: Infant, Newborn
subject: Neugeborenes

description: Importance The Apgar score is used worldwide as an assessment tool to estimate the vitality of newborns in their first minutes of life. Its applicability to estimate neurodevelopmental outcomes in infants born extremely preterm (EPT; <28 weeks’ gestation) is not well established. Objective To investigate the association between the Apgar score and neurodevelopmental outcomes in infants born EPT. Design, Setting, and Participants This cohort study was conducted using data from the Effective Perinatal Intensive Care in Europe-Screening to Improve Health in Very Preterm Infants in Europe (EPICE-SHIPS) study, a population-based cohort in 19 regions of 11 European countries in 2011 to 2012. Clinical assessments of cognition and motor function at age 5 years were performed in infants born EPT and analyzed in January to July 2023. Exposures Apgar score at 5 minutes of life categorized into 4 groups (0-3, 4-6, 7-8, and 9-10 points). Main Outcomes and Measures Cognitive and motor outcomes were assessed using the Wechsler Preschool and Primary Scale of Intelligence test of IQ derived from locally normed versions by country and the Movement Assessment Battery for Children–Second Edition. Parents additionally provided information on communication and problem-solving skills using the Ages and Stages Questionnaire, third edition (ASQ-3). All outcomes were measured as continuous variables. Results From the total cohort of 4395 infants born EPT, 2522 infants were live born, 1654 infants survived to age 5 years, and 996 infants (478 females [48.0%]) followed up had at least 1 of 3 outcome measures. After adjusting for sociodemographic variables, perinatal factors, and severe neonatal morbidities, there was no association of Apgar score with IQ, even for scores of 3 or less (β = −3.3; 95% CI, −10.5 to 3.8) compared with the score 9 to 10 category. Similarly, no association was found for ASQ-3 (β = −2.1; 95% CI, −24.6 to 20.4). Congruent results for Apgar scores of 3 or less were obtained for motor function scores for all children (β = −4.0; 95% CI, −20.1 to 12.1) and excluding children with a diagnosis of cerebral palsy (β = 0.8, 95% CI −11.7 to 13.3). Conclusions and Relevance This study found that low Apgar scores were not associated with longer-term outcomes in infants born EPT. This finding may be associated with high interobserver variability in Apgar scoring, reduced vitality signs and poorer responses to resuscitation after birth among infants born EPT, and the association of more deleterious exposures in the neonatal intensive care unit or of socioeconomic factors with greater changes in outcomes during the first 5 years of life.
Supplementary document for Quantum-randomized polarization of laser pulses derived from zero-point motion of diamond - 5004267.pdf
Creators: name: Little, Douglas
name: Kitzler, Ondrej
name: Abedi, Seyed
name: Alias, Akael
name: Gilchrist, Alexei
name: Mildren, Richard
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Derivation of Stokes fields and output of NIST 800-90B statistical tests
Whistleblowing: impediments to effective implementation within the South African public sector
Creators: name: Dorasamy, Nirmala
name: Pillay, Soma
Publisher: name: Swinburne
Year: 2024

description: This purpose of this article is to explore impediments to effective whistleblowing as a strategy for promoting anti-corruption practices within the South African public sector. Corruption, which violates the public service code of conduct; deters foreign investment, increases the cost of public service delivery, undermines the fight against poverty and unnecessarily burdens the criminal justice system. The article addresses the question on whether legislation on whistleblowing is adequate to encourage whistleblowing in the public sector. A review of literature determines that the effective implementation of whistleblowing legislation is largely dependent on addressing the challenges identified in the article. The quantitative research method was employed in the study to ascertain the views of employees in the public sector on whistleblowing. Empirical findings confirm the hypothesis that the protection of whistleblowers through legislation is inadequate to encourage whistleblowing. The article provides a conceptual framework for the effective achievement of the intended outcomes of whistleblowing in the public sector.