cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Induction of apoptosis by emestrin from the plant endophytic fungus Emericella nidulans ATCC 38163 in Huh-7 human hepatocellular carcinoma cells
Creators: name: El-Kassem, Lamia T. Abou
name: Hawas, Usama W.
name: Ahmed, Eman F.
name: Binothman, Najat
name: Alghamdi, Rana A.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: This research aimed to investigate the anticancer properties of emestrin, a major constituent of Emericella nidulans ATCC 38163 through the induction of apoptosis in Huh-7 human hepatocellular carcinoma cells. In this study, this fungus was isolated from the fresh leaves of Ruprechtia salicifolia (Cham. & Schltdl.) C.A. Mey, and identified by morphology and 18S rDNA followed by large-scale fermentation in liquid biomalt broth medium. Epidithiodioxopiperazine derivative emestrin along with ten known metabolites were isolated and identified from the fungal extract. The cytotoxic assay revealed that emestrin had the strongest cytotoxicity against Huh-7 and A-549 cells with IC50 values of 4.89 and 6.3 μM, respectively. Using annexin V-FITC assay, treatment of Huh-7 cells with 4.89 µM for 24 h resulted in a significant increase in the percentage of early and late apoptosis (3.16% and 22.84%, respectively) compared to untreated cells. Additionally, Bax and bcl-2 protein levels were regulated, which induced apoptosis in treated cells. These results indicate that emestrin induces mitochondrial pathway to stimulate apoptosis and inhibits cell proliferation in hepatocellular carcinoma.
Reducing effect of intragastrically administered saikosaponin A on alcohol and sucrose self-administration in rats
Creators: name: Maccioni, Paola
name: Chin, Young-Won
name: Corelli, Federico
name: Kwon, Hak Cheol
name: Colombo, Giancarlo
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Medicine
Pharmacology
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Saikosaponin A (SSA) is an active ingredient of the Asian medicinal herb, Bupleurum falcatum L. When administered via the intraperitoneal (i.p.) route, SSA suppressed multiple addictive-like behaviours, including operant alcohol self-administration, in rodents. It is unknown whether these effects are retained after intragastric (i.g.) administration, a desirable prerequisite for a compound with therapeutic potential. To fill this gap, i.g. SSA (0, 50, and 100 mg/kg) was tested in Sardinian alcohol-preferring (sP) rats trained to lever-respond for oral alcohol. SSA reduced lever-responding and amount of self-administered alcohol. However, when compared to i.p. SSA, i.g. SSA resulted to be markedly less potent and effective, suggestive of reduced bioavailability after i.g. treatment. Finally, and in agreement with previous data on the suppressing effect of i.p. SSA on behaviours motivated by highly palatable foods, i.g. SSA (0, 50, and 100 mg/kg) reduced oral sucrose self-administration in a separate set of sP rats.
Non-abelian higher gauge theory and categorical bundle
Creators: name: Viennot, David
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: A gauge theory is associated with a principal bundle endowed with a connection permitting to define horizontal lifts of paths. The horizontal lifts of surfaces cannot be defined into a principal bundle structure. An higher gauge theory is an attempt to generalize the bundle structure in order to describe horizontal lifts of surfaces. A such attempt is particularly difficult for the non-abelian case. Some structures have been proposed to realize this goal (twisted bundle, gerbes with connection, bundle gerbe, 2-bundle). Each of them uses a category in place of the total space manifold of the usual principal bundle structure. Some of them replace also the structure group by a category (more precisely a Lie crossed module viewed as a category). But the base space remains still a simple manifold (possibly viewed as a trivial category with only identity arrows). We propose a new principal categorical bundle structure, with a Lie crossed module as structure groupoid, but with a base space belonging to a bigger class of categories (which includes non-trivial categories), that we call affine 2-spaces. We study the geometric structure of the categorical bundles built on these categories (which is a more complicated structure than the 2-bundles) and the connective structures on these bundles. Finally we treat an example interesting for quantum dynamics which is associated with the Bloch wave operator theory.
Epigenetic-based antioxidant effect of an ethanolic extract of Corylus avellana L. on THLE-2 human primary hepatocytes
Creators: name: Benassi, Barbara
name: Bacchetta, Loretta
name: Maccioni, Oliviero
name: Pacchierotti, Francesca
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: The ethanolic extract of Corylus avellana L hazelnut, prepared in our laboratories, has been previously characterized by liquid chromatography coupled to high resolution mass spectrometry. We here aimed at testing the antioxidant effect of such extract in H2O2-challenged THLE-2 human primary hepatocytes and verified whether it might be based on microRNA-34b/c expression changes. We here demonstrate that miR-34b/miR-34c undergo significant stimulation (≥2-fold change, p < 0.05) in THLE-2 when treated for 72h with not-toxic hazelnut concentrations (0.04–0.4 mg/ml), when compared with 0.06% ethanol control. When administered with H2O2 (1000–2000 µM, 24h), THLE-2 are significantly protected from oxidative stress if pre-treated with hazelnut, the H2O2-driven cytotoxicity and reactive oxygen species generation being recovered by hazelnut extract, through miR-34b/c stimulation. Although preliminary, our findings pave the way for further preclinical studies aimed at validating the possible health-related application of hazelnut matrix, and/or its metabolites, as powerful epigenetic-based drugs, food supplements or nutraceuticals.
Uniqueness Results for Schroedinger Operators on the Line with Purely Discrete Spectra
Creators: name: Eckhardt, Jonathan
name: Teschl, Gerald
Publisher: name: arXiv
Year: 2011
Subjects: subject: Spectral Theory (math.SP)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 34B20, 34L05 (Primary) 34B24, 47A10 (Secondary)

description: We provide an abstract framework for singular one-dimensional Schroedinger operators with purely discrete spectra to show when the spectrum plus norming constants determine such an operator completely. As an example we apply our findings to prove a new uniqueness results for perturbed quantum mechanical harmonic oscillators. In addition, we also show how to establish a Hochstadt-Liebermann type result for these operators. Our approach is based on the singular Weyl-Titchmarsh theory which is extended to cover the present situation.
description: 19 pages
Additional file 1 of Can high-flow nasal cannula reduce the risk of bronchopulmonary dysplasia compared with CPAP in preterm infants? A systematic review and meta-analysis
Creators: name: de Jesus Brito, Sabrina
name: Tsopanoglou, Sabrina Pinheiro
name: Galvão, Endi Lanza
name: de Deus, Franciele Angelo
name: de Lima, Vanessa Pereira
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 1. PRISMA 2009 Checklist.
Innovation diffusion, technological convergence and economic growth
Creators: name: Andergassen, Rainer
name: Nardini, Franco
name: Ricottilli, Massimo
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2013
Subjects: SECS-P/02 Politica economica

description: The paper investigates the mechanics through which novel technological principles are developed and diffused throughout an economy consisting of a technologically heterogeneous ensemble of firms. In the model entrepreneurs invest in the discovery and in the diffusion of a technological principle and their profit flow depends on how many firms adopt the innovation and on how long it takes other entrepreneurs to improve it. We show that technological convergence emerges from the competition among entrepreneurs for the profit flow and characterize the economy's growth rate.
Ultra-cold bosons in zig-zag optical lattices
Creators: name: Greschner, S.
name: Santos, L.
name: Vekua, T.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Ultra-cold bosons in zig-zag optical lattices present a rich physics due to the interplay between frustration, induced by lattice geometry, two-body interaction and three-body constraint. Unconstrained bosons may develop chiral superfluidity and a Mott-insulator even at vanishingly small interactions. Bosons with a three-body constraint allow for a Haldane-insulator phase in non-polar gases, as well as pair-superfluidity and density wave phases for attractive interactions. These phases may be created and detected within the current state of the art techniques.
description: 8 pages, 9 figures
Two inverse spectral problems for a class of singular Krein strings
Creators: name: Eckhardt, Jonathan
Publisher: name: arXiv
Year: 2012
Subjects: subject: Spectral Theory (math.SP)
subject: FOS: Mathematics
subject: Primary 34A55, 34B05, Secondary 47E05, 34L40

description: We solve the inverse problem from the spectral measure and the inverse three-spectra problem for the class of singular Krein strings on a finite interval with trace class resolvents. In particular, this includes a complete description of all possible spectral measures and three (Dirichlet) spectra associated with this class of Krein strings. The solutions of these inverse problems are obtained by approximation with Stieltjes strings.
description: 16 pages
Additional file 2 of Can high-flow nasal cannula reduce the risk of bronchopulmonary dysplasia compared with CPAP in preterm infants? A systematic review and meta-analysis
Creators: name: de Jesus Brito, Sabrina
name: Tsopanoglou, Sabrina Pinheiro
name: Galvão, Endi Lanza
name: de Deus, Franciele Angelo
name: de Lima, Vanessa Pereira
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 2. Search strategies.
Additional file 3 of Can high-flow nasal cannula reduce the risk of bronchopulmonary dysplasia compared with CPAP in preterm infants? A systematic review and meta-analysis
Creators: name: de Jesus Brito, Sabrina
name: Tsopanoglou, Sabrina Pinheiro
name: Galvão, Endi Lanza
name: de Deus, Franciele Angelo
name: de Lima, Vanessa Pereira
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 3. Main methodological characteristics of included studies.
Invariance properties of random vectors and stochastic processes based on the zonoid concept
Creators: name: Molchanov, Ilya
name: Schmutz, Michael
name: Stucki, Kaspar
Publisher: name: arXiv
Year: 2012
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: Two integrable random vectors $ξ$ and $ξ^*$ in $\mathbb {R}^d$ are said to be zonoid equivalent if, for each $u\in \mathbb {R}^d$, the scalar products $\langleξ,u\rangle$ and $\langleξ^*,u\rangle$ have the same first absolute moments. The paper analyses stochastic processes whose finite-dimensional distributions are zonoid equivalent with respect to time shift (zonoid stationarity) and permutation of its components (swap invariance). While the first concept is weaker than the stationarity, the second one is a weakening of the exchangeability property. It is shown that nonetheless the ergodic theorem holds for swap-invariant sequences and the limits are characterised.
description: Published in at http://dx.doi.org/10.3150/13-BEJ519 the Bernoulli (http://isi.cbs.nl/bernoulli/) by the International Statistical Institute/Bernoulli Society (http://isi.cbs.nl/BS/bshome.htm)
Investigating the spinal cord atrophy measurement on MRI from two aspects : physiological variations and longitudinal measurement methods
Creators: name: Wang, Chunfang
Publisher: name: University of British Columbia
Year: 2014

description: Spinal cord atrophy is a valuable biomarker in multiple sclerosis (MS) for its significant correlation with physical disability. Measurement of spinal cord atrophy on MRI may be possibly confounded by fluctuations in water content, and the high measurement variance in previous longitudinal studies can be possibly reduced by registration-based methods. In this thesis, we investigated the effect of change in water content due to hydration status on cord cross-sectional area (CSA) measurement, and the applicability of three registration-based methods for longitudinal cord atrophy measurement. Our first hypothesis is that dehydration can decrease the cord CSA measurement on MRI. We found a mean decrease of 0.65% in CSA on scans collected from ten controls following a dehydration protocol using two independent cross-sectional CSA measurement methods. Our result demonstrates that change in water content of the cord is associated with measurable change in cord CSA. The second main hypothesis is that registration-based methods can decrease the variance in longitudinal cord atrophy measurement by using the signal from multiple scans to improve robustness to image noise and artifacts and by regularization of the registration to constrain the degrees of freedom. We implemented three algorithms: boundary shift integral based on rigid registration, Jacobian integration based on deformable registration and scale factor computation based on constrained registration (composed of rigid and scale transformation). We evaluated the three registration-based methods by comparing them to two cross-sectional methods, as applied to three longitudinal data sets: 1) images with simulated cord atrophy; 2) images acquired in the dehydration study described above; and 3) images of 15 MS patients over a two-year interval. Our main result was that while registration-based methods achieved more accurate results on simulation data sets and overall smaller measurement variance, they were not as sensitive, reporting no dehydration effect and smaller magnitude of patient cord atrophy. We argue that the limited spatial resolution of 1mm of MR scans in our experiment is possibly the main reason and future studies of cord atrophy measurement using registration-based methods should be conducted on MR scans with a high spatial resolution such as 0.5mm.
Gaussian Entanglement for Quantum Key Distribution from a Single-Mode Squeezing Source
Creators: name: Eberle, Tobias
name: Händchen, Vitus
name: Duhme, Jörg
name: Franz, Torsten
name: Furrer, Fabian
name: Schnabel, Roman
name: Werner, Reinhard F.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We report the suitability of an Einstein-Podolsky-Rosen (EPR) entanglement source for gaussian continuous-variable quantum key distribution at 1550 nm. Our source is based on a single continuous-wave squeezed vacuum mode combined with a vacuum mode at a balanced beam splitter. Extending a recent security proof, we characterize the source by quantifying the extractable length of a composable secure key from a finite number of samples under the assumption of collective attacks. We show that distances in the order of 10 km are achievable with this source for a reasonable sample size despite the fact that the entanglement was generated including a vacuum mode. Our security analysis applies to all states having an asymmetry in the field quadrature variances, including those generated by superposition of two squeezed modes with different squeezing strengths.
description: 13 pages, 5 figures
Identification of thrombin inhibiting antithrombin-III like protein from Punica granatum using in silico approach and in vitro validation of thrombin inhibition activity in crude protein
Creators: name: Jindal, Shanky
name: Kant, Ravi
name: Saluja, Daman
name: Aggarwal, Kamal Krishan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Hematology

description: Thrombosis is characterized by the formation of clots in the blood vessels. Antithrombin-III deficiency in the blood causes thrombus formation. Supplementing antithrombin-III may serve as anticoagulant therapy. In the present studies, an antithrombin like Protein from Punica granatum has been identified and characterized using in silico approach. Based on sequence homology, an ALPP was selected depending upon its highest binding affinity of −41.28 kcal/mol with thrombin. Thrombin structure complexed with ALPP was docked with TAME using AutoDock Vina. No binding was observed for TAME at Ser195 of thrombin. MD simulation (50 ns) was performed to evaluate the flexibility and stability of docked complexes. In vitro assays with crude protein showed 78% thrombin inhibition at 5 µg and calculated IC50 value was 0.188 µg. The presence of thrombin inhibitors in crude protein was also confirmed by reverse zymography. Thus, it is very likely that the protein identified from P. granatum may act as thrombin inhibitor.
MacWilliams Identities for $m$-tuple Weight Enumerators
Creators: name: Kaplan, Nathan
Publisher: name: arXiv
Year: 2012
Subjects: subject: Information Theory (cs.IT)
subject: Combinatorics (math.CO)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: 94B05

description: Since MacWilliams proved the original identity relating the Hamming weight enumerator of a linear code to the weight enumerator of its dual code there have been many different generalizations, leading to the development of $m$-tuple support enumerators. We prove a generalization of theorems of Britz and of Ray-Chaudhuri and Siap, which build on earlier work of Kløve, Shiromoto, Wan, and others. We then give illustrations of these $m$-tuple weight enumerators.
description: 17 pages. Accepted to SIAM Journal on Discrete Mathematics
Additional file 4 of Can high-flow nasal cannula reduce the risk of bronchopulmonary dysplasia compared with CPAP in preterm infants? A systematic review and meta-analysis
Creators: name: de Jesus Brito, Sabrina
name: Tsopanoglou, Sabrina Pinheiro
name: Galvão, Endi Lanza
name: de Deus, Franciele Angelo
name: de Lima, Vanessa Pereira
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 4. Characteristics of the participants enrolled in studies.
Chemical composition and anticancer activity of the essential oil from Vicia ochroleuca Ten., quite rare plant in Kabylia (Algeria)
Creators: name: Boussaha, Sara
name: Bramucci, Massimo
name: Rebbas, Khellaf
name: Quassinti, Luana
name: Mekkiou, Ratiba
name: Maggi, Filippo
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Hematology

description: The search for new bioactive substances with anticancer activity and the understanding of their mechanisms of action are high priorities in the research effort toward more effective cancer treatments. In this article, we analyzed, for the first time, the chemical composition of the essential oil (EO) hydrodistilled from the aerial parts of Vicia ochroleuca Ten. (Leguminosae) by GC–MS. A total of sixteen compounds representing 82.2% of the total composition were identified. The major compounds were phytone (20.11%), hexadecanoic acid (10.23%), 1-octen-3-ol (9.84%), and 10-epi-α-cadinol (7.13%). Additionally, using the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) method, the EO was tested in vitro against a panel of human cancer cells, including breast (MDA-MB 231), colon (HCT116), melanoma (A375), and glioblastoma (T98G), with corresponding IC50 values of 23.07, 47.05, 51.64, and 64.07 μg/mL, respectively. The results demonstrate cytotoxic activity and suggest that V. ochroleuca EO could be regarded as a natural bioactive source.
Classical and quantum partition bound and detector inefficiency
Creators: name: Laplante, S.
name: Lerays, V.
name: Roland, J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: Computational Complexity (cs.CC)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We study randomized and quantum efficiency lower bounds in communication complexity. These arise from the study of zero-communication protocols in which players are allowed to abort. Our scenario is inspired by the physics setup of Bell experiments, where two players share a predefined entangled state but are not allowed to communicate. Each is given a measurement as input, which they perform on their share of the system. The outcomes of the measurements should follow a distribution predicted by quantum mechanics; however, in practice, the detectors may fail to produce an output in some of the runs. The efficiency of the experiment is the probability that the experiment succeeds (neither of the detectors fails). When the players share a quantum state, this gives rise to a new bound on quantum communication complexity (eff*) that subsumes the factorization norm. When players share randomness instead of a quantum state, the efficiency bound (eff), coincides with the partition bound of Jain and Klauck. This is one of the strongest lower bounds known for randomized communication complexity, which subsumes all the known combinatorial and algebraic methods including the rectangle (corruption) bound, the factorization norm, and discrepancy. The lower bound is formulated as a convex optimization problem. In practice, the dual form is more feasible to use, and we show that it amounts to constructing an explicit Bell inequality (for eff) or Tsirelson inequality (for eff*). We give an example of a quantum distribution where the violation can be exponentially bigger than the previously studied class of normalized Bell inequalities. For one-way communication, we show that the quantum one-way partition bound is tight for classical communication with shared entanglement up to arbitrarily small error.
description: 21 pages, extended version
Phytochemical analysis, antioxidant and hypoglycemic activities of a methanol extract from Stachys brachyclada de Noé ex Coss. leaves
Creators: name: Lemoui, Redouane
name: Picerno, Patrizia
name: Benyahia, Samira
name: Mencherini, Teresa
name: Vassallo, Antonio
name: Armentano, Maria Francesca
name: Noman, Labib
name: Bouchama, Khaled
name: Rastrelli, Luca
name: Aquino, Rita Patrizia
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology
subject: Virology

description: Stachys brachyclada de Noé ex Coss. (Lamiaceae) is a quite rare medicinal plant endemic to the Mediterranean basin. In this study, seven secondary metabolites from a methanol extract of its leaves have been isolated and identified by a combination of chromatographic and spectroscopic methods (1D and 2D NMR experiments and ESIMS analysis). They include one ethyl 4-hydroxybenzoate (1), three acylated flavone glycosides (2–4), one diapigenin derivative (5) and two flavone aglycones (6–7). Stachysetin (5) was found the major compound of the extract (74.0 mg/g of dry matter). Moreover, the produced extract showed the ability in inhibiting the α-glucosidase enzyme (IC50 = 13.7 µg/mL), in quenching the radical 1,1-diphenyl-2-picrylhydrazyl (EC50 = 74.6 µg/mL), and in reducing the intracellular oxidative stress level in Human Dermal Fibroblast (64% inhibition at 50 µg/mL).
2-(Benzhydryl sulfinyl)-N-sec-butylacetamide) isolated from fig augmented trastuzumab-triggered phagocytic killing of cancer cells through interface with Fcγ receptor
Creators: name: Ali, Eman T.
name: Al-Salman, H. N. K.
name: Rasool, Khetam H.
name: Jabir, Majid S.
name: Ghimire, Tirth R.
name: Shari, Falah H.
name: Hussein, Hussein H.
name: Al-Fregi, Adil A.
name: Sulaiman, Ghassan M.
name: Khalil, Khalil A. A.
name: Ahmed, Elsadig M.
name: Soliman, Mohamed T. A.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: The objective of the current study was to extract 2-(benzhydryl sulfinyl)-N-sec-butylacetamide), a novel compound from fig, and then determine its role in enhancing trastuzumab-triggered phagocytic killing of SKOV-3 cancer cells. In this study, Soxhlet was used to extract the compound from the mature and air-dried fig fruits. The production of the isolated extracts was enhanced by using polar and non-polar solvents. Several solvents, such as methanol, ethyl acetate, chloroform, and n-hexane, were used to isolate the effective compound 2-(benzhydryl sulfinyl)-N-sec-butylacetamide) from the organic layer. UV-spectroscopy, FT-IR, 1H-NMR, and 13C-NMR were applied to identify the purified compound. The in vitro and in vivo assays demonstrated that the 2-(benzhydryl sulfinyl)-N-sec-butylacetamide) can increase the activity of the phagocytic cells, via the interaction with FcY receptors, along with trastuzumab, and the pathway can use a model for the therapeutic strategy for effective treatment of ovarian cancer cells.
Additional file 5 of Can high-flow nasal cannula reduce the risk of bronchopulmonary dysplasia compared with CPAP in preterm infants? A systematic review and meta-analysis
Creators: name: de Jesus Brito, Sabrina
name: Tsopanoglou, Sabrina Pinheiro
name: Galvão, Endi Lanza
name: de Deus, Franciele Angelo
name: de Lima, Vanessa Pereira
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 5. Assessment of risk of bias of included clinical trial studies.
Additional file 6 of Can high-flow nasal cannula reduce the risk of bronchopulmonary dysplasia compared with CPAP in preterm infants? A systematic review and meta-analysis
Creators: name: de Jesus Brito, Sabrina
name: Tsopanoglou, Sabrina Pinheiro
name: Galvão, Endi Lanza
name: de Deus, Franciele Angelo
name: de Lima, Vanessa Pereira
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 6. GRADE scale.
Slow interaction ramps in trapped many-particle systems: universal deviations from adiabaticity
Creators: name: Haque, Masudul
name: Zimmer, F. E.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: For harmonic-trapped atomic systems, we report system-independent non-adiabatic features in the response to interaction ramps. We provide results for several different systems in one, two, and three dimensions: bosonic and fermionic Hubbard models realized through optical lattices, a Bose-Einstein condensate, a fermionic superfluid and a fermi liquid. The deviation from adiabaticity is characterized through the heating or excitation energy produced during the ramp. We find that the dependence of the heat on the ramp time is sensitive to the ramp protocol but has aspects common to all systems considered. We explain these common features in terms of universal dynamics of the system size or cloud radius.
description: v3: Published (expanded) version, 7+ pages, 4 figures. v2: Shorter, 4+ pages, 3 figures. Related preprint arXiv:1012.4492 describes similar dynamics for BEC only
Seepage Induced Consolidation Test : characterization of mature fine tailings
Creators: name: Estepho, Mathiew
Publisher: name: University of British Columbia
Year: 2014

description: Managing oil sand slurry tailings waste is a significant issue in the oil sands industry and thus accurate characterization of the tailings is required. Conventional soil characterization tests usually involve one or more limiting assumptions such as small strains and constant coefficients of consolidation and hydraulic conductivity. These limitations are significant when testing low density slurries such as dredged soils and mining waste. One unconventional test in particular, the Seepage Induced Consolidation Test (SICT) has been shown to accurately determine compressibility and permeability relations for low density slurries. The SICT was first constructed at the Colorado University (CU) in Boulder, Colorado and has been used for the past two decades to characterize phosphate slurry tailings. Over the last two years a SICT was constructed at the University of British Columbia to provide accurate consolidation characterization of oil sand waste, in particular, mature fine tailings (MFT). Benchmark testing was initially performed on kaolinite clay at the UBC laboratory and results showed the test was repeatable and comparable to results obtained at CU. Test results on MFT at UBC also proved to be in agreement with published data from CU. The use of the SICT helps in the understanding of MFT and the characterization results can be directly used in into large strain consolidation modeling such as CONDES0 1D and SoilVision’s SVOffice 1D, 2D, and 3D software programs. These and other similar models, which are dependent on the compressibility and permeability relations from the SICT, can be used in the design of waste disposal strategies at every stage of a mining project.
Representation varieties of Fuchsian groups
Creators: name: Larsen, Michael
name: Lubotzky, Alexander
Publisher: name: arXiv
Year: 2012
Subjects: subject: Algebraic Geometry (math.AG)
subject: Group Theory (math.GR)
subject: FOS: Mathematics

description: We estimate the dimension of varieties of the form Hom(F,G) where F is a Fuchsian group and G is a simple real algebraic group, answering along the way a question of I. Dolgachev.
description: Lemma 2.3 of version 1 (renumbered 3.3 in this version for consistency with the published version) was incorrect as stated. This version proves a weaker version of Lemma 3.3 and a correspondingly strengthened version of Theorem 3.4. The main theorems are unchanged
In vitro cytotoxic capacity against tumor cell lines and antioxidant activity of acidic polysaccharides isolated from the Andean Patagonian fungus Phylloporia boldo
Creators: name: Albornoz, Verónica
name: Casas-Arrojo, Virginia
name: Figueroa, Fabián
name: Riquelme, Cristian
name: Hernández, Víctor
name: Rajchenberg, Mario
name: Smith, Carlos T.
name: Campos, Víctor L.
name: Abdala-Díaz, Roberto T.
name: Becerra, José
name: Pérez, Claudia
name: Cabrera-Pardo, Jaime R.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Plasma Physics
subject: Plant Biology

description: Fungal polysaccharides possess a broad biological activity, including cytotoxic and antioxidant activities. This work aimed to evaluate the cytotoxic and antioxidant activity of the acidic polysaccharides of Phylloporia boldo strain (named PBAP40). Cytotoxic activity of polysaccharide was evaluated determining the viability of three tumor cell lines by MTT assay. The effect of acidic polysaccharide on the cell cycle of HL-60 cell line was evaluated by flow cytometry, and the antioxidant activity was determined by DPPH and ABTS assays. PBAP40 showed cytotoxic effects in tumor cell lines. Results suggest that P. boldo acidic polysaccharides arrested tumor cells in the cell cycle Sub G1 phase. The acidic polysaccharides of PBAP40 strain were not cytotoxic for the non-tumor cell line. PBAP40 also showed excellent antioxidant activity. The FT-IR analysis of the acidic polysaccharides indicated the presence of glucans bearing α- and β- type glycosidic bonds.
LHC explores what LEP hinted at: CP-violating type-I 2HDM
Creators: name: Mader, Wolfgang
name: Park, Jae-hyeon
name: Pruna, Giovanni Marco
name: Stöckinger, Dominik
name: Straessner, Arno
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The Large Hadron Collider is shown to have great scope for a light charged Higgs discovery, in the context of the CP-violating type-I two Higgs doublet model. This scenario with similar masses of $H^\pm$ and W was suggested by the puzzling departure from charged current lepton universality found in the LEP data. With the lightest neutral Higgs mass set to 125 GeV, the charged-neutral Higgs associated production mechanism can cause a significant excess in the $τνb \bar{b}$ events over a vast range of tan beta as long as the Higgs mixing pattern avoids a few limiting cases. Thanks to the low $H^\pm$ mass, the charged Higgs loop can play a striking role in neutral Higgs decays into $γγ$, thereby compensating for a suppressed gluon-gluon fusion rate. The effect of scalar-pseudo-scalar mixing on loop-induced Higgs signals is also discussed.
description: 25 pages, corrected a numerical error in Fig. 4 and a typo, conclusions unchanged
Scattering in Multilayered Structures: Diffraction from a Nanohole
Creators: name: Fernandez-Corbaton, Ivan
name: Tischler, Nora
name: Molina-Terriza, Gabriel
Publisher: name: arXiv
Year: 2011
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The spectral expansion of the Green's tensor for a planar multilayered structure allows us to semi analytically obtain the angular spectrum representation of the field scattered by an arbitrary dielectric perturbation present in the structure. In this paper we present a method to find the expansion coefficients of the scattered field, given that the electric field inside the perturbation is available. The method uses a complete set of orthogonal vector wave functions to solve the structure's vector wave equation. In the two semi-infinite bottom and top media, those vector wave functions coincide with the plane-wave basis vectors, including both propagating and evanescent components. The technique is used to obtain the complete angular spectrum of the field scattered by a nanohole in a metallic film under Gaussian illumination. We also show how the obtained formalism can easily be extended to spherically and cylindrically multilayered media. In those cases, the expansion coefficients would multiply the spherical and cylindrical vector wave functions.
description: 9 pages, 5 figures
(Non-) geodesic motion in chameleon Brans Dicke model
Creators: name: Saaidi, Khaled
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Based on \cite{16}, we assume there is a non-minimal coupling between the scalar field and matter in Brans-Dicke model. We analyzes the motion of different matter such as, massless scalar field, photon, massless perfect fluid (dust), massive perfect fluid and point particle matter in this theory. We show that the motion of massless scalar field and photon can satisfy null geodesic motion only in high frequency limit. Also we find that the motion of the dust and massive perfect fluid is geodesic for $L_m=-P$ and is non-geodesic for $L_m=\R$. Finally, we study the motion of point particle and show that the motion of this kind of matter is non-geodesic.
description: 7 pages, no figures
Additional file 1 of Considerations for prostheses choice in multiple valve surgery
Creators: name: Poostizadeh, Ahmad
name: Jamieson, W. R. Eric
name: Munro, A. Ian
name: Miyagishima, Robert T.
name: Ling, Hilton
name: Fradet, Guy J.
name: Janusz, Michael T.
name: Burr, Lawrence H.
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy

description: Additional file 1. Figure E1. Patient survival—bioprostheses and mechanical prostheses populations. Figure E2. Freedom from the composites of valve-related reoperation, valve-related residual morbidity and valve-related mortality. Table E1. Etiology of overall mortality. Table E2. Etiology of early mortality of valve-related reoperation. Table E3. Freedom from combined composites of valve-related complications (reoperation, mortality and morbidity) by procedures—bioprostheses (969) and mechanical prostheses (743), for age groups at 10 years.
Explicit Thin-Lens Solution for an Arbitrary Four by Four Uncoupled Beam Transfer Matrix
Creators: name: Balandin, Vladimir
name: Orlov, Sergey
Publisher: name: arXiv
Year: 2011
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: In the design of beam transport lines one often meets the problem of constructing a quadrupole lens system that will produce desired transfer matrices in both the horizontal and vertical planes. Nowadays this problem is typically approached with the help of computer routines, but searching for the numerical solution one has to remember that it is not proven yet that an arbitrary four by four uncoupled beam transfer matrix can be represented by using a finite number of drifts and quadrupoles (representation problem) and the answer to this questions is not known not only for more or less realistic quadrupole field models but also for the both most commonly used approximations of quadrupole focusing, namely thick and thin quadrupole lenses. In this paper we make a step forward in resolving the representation problem and, by giving an explicit solution, we prove that an arbitrary four by four uncoupled beam transfer matrix actually can be obtained as a product of a finite number of thin-lenses and drifts.
description: 10 pages, no figures
Larvicidal activity of hexane extract, fatty acids, and methyl esters from Tecoma stans pericarps against Culex quinquefasciatus
Creators: name: da Silva, Adriano Lopes
name: Azevedo, Lucas Santos
name: Gonçalves, Thaís Paula Rodrigues
name: Coimbra, Mairon César
name: de Siqueira, Ezequias Pessoa
name: Alves, Stênio Nunes
name: dos Santos Lima, Luciana Alves Rodrigues
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Culex quinquefasciatus (Diptera: Culicidae) is responsible for the transmission of lymphatic filariasis. The search for natural sources of new insecticides to control mosquitoes has intensified in recent years. Tecoma stans is an exotic species in Brazil, known as ‘ipê de jardim’. T. stans pericarps were extracted with hexane in Soxhlet apparatus, and fatty acids (FA) and methyl esters (FAME) were obtained by transesterification reaction of hexane extract (HE). HE, FA, and FAME were evaluated against 3rd. and 4th. instar larvae of Culex quinquefasciatus. Analysis by gas chromatography-mass spectrometry (GC/MS) identified the hydrocarbon nonacosane (81.69%) as the major compound in HE, and linolenic (16.89%), linoleic (16.83%), and palmitic acids (21.00%) were predominant in FA. FA and HE, at a concentration of 250 µg/mL, promoted mortality of 81.67% and 68.66% of larvae, respectively. HE and FA obtained from T. stans pericarps have larvicidal potential for the control of C. quinquefasciatus.
Three types of wartime sexual violence : recruitement and retention of armed combatants in civil war
Creators: name: Luedke, Alicia Elaine
Publisher: name: University of British Columbia
Year: 2014

description: Most mainstream studies of violence in civil war have focused almost exclusively on lethal forms of violence against civilians, emphasizing the dilemmas of initiating and sustaining an insurgency from the perspective of an armed group’s leadership. Consequently, little research has been conducted to account for what kinds of insurgent organizations will engage in what ‘types’ of wartime sexual violence. By ‘type’ of wartime sexual violence, this paper refers to its purposes as: i.) a reward for foot soldiers and tool of opportunism; ii.) a weapon of war for threatening and intimidating a population; and iii.) a mechanism for facilitating in-group cohesion and discipline. It argues that by extending and elaborating on the logics used to explain lethal violence against civilians, i.e. the recruitment and retention of armed combatants in civil war, analyses can predict the ‘type’ of sexual violence a given armed group is likely to engage in during combat. Focusing on a typology of sexual violence constructed around armed group objectives not only offers a more detailed analytical account of insurgent behavior, but also advances the already limited study of sexual violence beyond subsets, such as rape or gang rape. After presenting this typology, the paper offers a theoretical framework and preliminary set of hypotheses with respect to what kinds of armed groups will commit which of these three types of wartime sexual violence. It concludes with a discussion of mixed method micro-comparative research designs and geographic information systems (GIS) as possible ways for researchers to distinguish between different outcomes of sexual violence in armed conflict.
Additional file 1 of “It is the One Thing that has Worked”: facilitators and barriers to switching to nicotine salt pod system e-cigarettes among African American and Latinx people who smoke: a content analysis
Creators: name: Pulvers, Kim
name: Rice, Myra
name: Ahluwalia, Jasjit S.
name: Arnold, Michael J.
name: Marez, Crystal
name: Nollen, Nicole L.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Frequencies of what liked about using JUUL by week 6 trajectory. Displays the frequencies of what participants liked about using JUUL by week 6 trajectory (exclusive JUUL use, dual JUUL and cigarette use, and continued cigarette use). Panel A shows the full sample, and Panels B and C show results split by the African American sample and the Latinx sample, respectively.
Cholinesterase, α-glucosidase, tyrosinase and urease inhibitory activities of compounds from fruits of Rinorea oblongifolia C.H. Wright (Violaceae)
Creators: name: Munvera, Aristide Mfifen
name: Ngenge, Tamfu Alfred
name: Ouahouo, Blandine Marlyse Wache
name: Kucukaydin, Selcuk
name: Nyemb, Jean Noel
name: Mafo, Marcelle Aude Fokam
name: Tchapo, Emar Carlain Djappa
name: Mkounga, Pierre
name: Nkengfack, Augustin Ephrem
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: From Rinorea oblongifolia fruits, 3-Nor-4β-friedelan-24-ol (1) and 3-decyl-6,7,8-trimethoxy-2H,5H-furo[4,3,2-de]isochromene-2,5-dione (4), new derivatives alongside, 28-hydroxyfriedelan-3-one (2), friedelin (3), 3,3’,4,4’,5’-pentamethylcoruleoellagic acid (5), hexamethylcoruleoellagic acid (6), 3’,4,4’,5,5’-pentamethylcoruleoellagic acid (7), and fatty compounds 8-11 were isolated and characterized using HRESIMS, EIMS, 1D and 2D NMR. In vitro enzyme inhibition of compounds 1, 2, 4, 5, 6 and 7 were evaluated on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-glucosidase, urease and tyrosinase. Against AChE and BChE, the phenolic compounds 4, 5, 6, and 7 had good activity probably due to the phenolic nature and methoxy substituents. Compounds 4, 5, 6 and 7 exhibited good α-glucosidase inhibition especially compound 4 whose IC50 = 42.45 ± 0.46 µg/mL was close that of acarbose (IC50 = 20.52 ± 0.84 µg/mL) standard drug. Urease and tyrosinase were appreciably inhibited by the compounds. Overall results of enzyme inhibitory assays indicate Rinorea oblongifolia, fruits and its constituents as potential remedy for enzymatic disorders.
Additional file 1: of The placental transcriptome of the first-trimester placenta is affected by in vitro fertilization and embryo transfer
Creators: name: Zhao, Liang
name: Zheng, Xiuli
name: Liu, Jingfang
name: Zheng, Rong
name: Yang, Rui
name: Wang, Ying
name: Sun, Lifang
Publisher: name: figshare
Year: 2019
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Table S1. Detail information on the selection of primers for real-time RT-PCR experiments (DOC 34 kb)