cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Primary versus non-primary maternal cytomegalovirus infection as a cause of symptomatic congenital infection – register-based study from Finland
Creators: name: Puhakka, Laura
name: Renko, Marjo
name: Helminen, Merja
name: Peltola, Ville
name: Heiskanen-Kosma, Tarja
name: Lappalainen, Maija
name: Heljä-Marja Surcel
name: Lönnqvist, Tuula
name: Saxen, Harri
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Ecology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: Background: Both primary and non-primary maternal cytomegalovirus (CMV) infection during pregnancy can lead to vertical transmission. We evaluated the proportion of maternal primary/non-primary infections among 26 babies with symptomatic congenital CMV infection born in Finland from 2000 to 2012. Methods: We executed a database search on hospital records from all five university hospitals in Finland to identify infants with congenital CMV infection. The preserved maternal serum samples drawn at the end of the first trimester were analysed for CMV antibodies. Maternal infection was classified to be non-primary, if there was high avidity CMV immunoglobulin G (IgG) in the early pregnancy samples. Infection was considered primary in the case of either low avidity IgG (primary infection in the first trimester or near conception) or absent CMV IgG at the end of the first trimester (primary infection in the second or third trimester). Results: The majority of the symptomatic congenital CMV infections (54%) were due to maternal non-primary infection, 27% due to maternal primary infection in the first trimester or near conception, and 19% during the second or third trimester. Long-term sequelae occurred in 59% of patients: in 6/7 after primary infection in the first trimester, in 0/5 after primary infection in the second or third trimester, and in 9/14 after non-primary infection. Conclusions: In this register-based cohort, non-primary infections caused the majority of symptomatic congenital CMV infections, and resulted in significant morbidity.
Role of surgical thoracic sympathetic interruption in treatment of facial blushing: A systematic review
Creators: name: Girish Girish
name: Rovan E D’Souza
name: Preethy D’Souza
name: Lewis, Melissa G
name: Baker, Daryll M
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Objectives: This paper aims to review the evidence to support the effectiveness of sympathectomy as a treatment for facial blushing in terms of relief of facial blushing, patient satisfaction, recurrence of blushing, patients regretting treatment and its associated complications. Methods: A systematic search strategy was performed in Ovid-Medline, Embase, Cochrane library and NICE. Studies reporting outcomes of sympathetic interruption in the treatment of facial blushing were retrieved. Results: Nine studies met the inclusion criteria with 1369 patients included in the final analysis. The age range of patients was 8 to 74 years (from 7 studies) with 56% females. Mean follow up was 21 months in 8 studies (range 6 to 30 months). The pooled proportion of patients who had good relief of facial blushing was 78.30% (95% C.I. 58.20% - 98.39%). Complete satisfaction was reported in 84.02% (95% C.I. 71.71% - 96.33%). Compensatory sweating and gustatory sweating were the commonest complications occurring in 74.18% (95% C.I. 58.10% - 90.26%) and 24.42% (95% C.I. 12.22% - 36.61%) respectively. The estimated proportion of patients regretting surgery was 6.79% (C.I 2.08% -11.50%). Conclusion: Sympathetic interruption at T2 or T2-3 ganglia appears to be an effective treatment for facial blushing. However, lack of randomized trials comparing sympathetic interruption with non-surgical methods of treatment and heterogeneity of included studies with respect to assessment of outcome measures preclude strong evidence and definitive recommendations.
Additional file 1: of Variability and reliability study of overall physical activity and activity intensity levels using 24Â h-accelerometry-assessed data
Creators: name: Jaeschke, Lina
name: Steinbrecher, Astrid
name: Jeran, Stephanie
name: Konigorski, Stefan
name: Pischon, Tobias
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Correlations between observed and true physical activity based on a given number of days of assessment. Summarizes the correlation, r, between observed and (unknown) true mean of six physical activity (PA) parameters, estimated depending on the number of days, D, of repeated PA assessments. Calculation is based on an equation by Black et al. using between-person, sb2, and within-person variance, sw2, solved for r [19]. (DOCX 20Â kb)
title: Emerged or not Emerged – the Influence of Emergence Boxes on the Evaluation of Emergence in Larval Toxicity Tests
Creators: name: Glaser, Simone
name: Haslauer, Kristin
name: Swiatlowska, Marta
name: Kling, Annette
Publisher: name: Bundesbehörden und Einrichtungen im Geschäftsbereich des Bundesministeriums für Ernährung und Landwirtschaft (BMEL)
Year: 2025
Subjects: subject: 630

description: Julius-Kühn-Archiv, vol. 481Hazards of pesticides to bees, 16th International Symposium of the ICP-PR Bee Protection Group, - Proceedings -; 15th - 17th October, 2024; Sevilla (Spain), p. 110
Additional file 1: of Development of leafhopper cell culture to trace the early infection process of a nucleorhabdovirus, rice yellow stunt virus, in insect vector cells
Creators: name: Wang, Haitao
name: Wang, Juan
name: Xie, Yunjie
name: Fu, Zhijun
name: Wei, Taiyun
name: Zhang, Xiao-Feng
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Sequences of the forward primer and reverse primer for RYSV N, P, M and Nephotettix cincticeps actin genes. (PDF 10 kb)
Ontwikkelingen NLBIF 2019
Creators: name: Raes, Niels
Publisher: name: Zenodo
Year: 2020
Subjects: GBIF
NLBIF
Open data
DiSSCo
Catalogue of Life

description: Presentatie over de ontwikkelingen die zich hebben voorgedaan van eind 2018 tot begin 2020 bij de Nederlandse GBIF node - NLBIF. De presentatie is gehouden door de NLBIF node manager, Niels Raes.
Fig.S1. 13C enrichment in media at the end of in vitro experiment from A fungal symbiont converts provisioned cellulose into edible yield for its leafcutter ant farmers
Creators: name: Conlon, Benjamin H.
name: O'Tuama, David
name: Michelsen, Anders
name: Crumière, Antonin J. J.
name: Shik, Jonathan Z.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: The media at the end of the experimental period was still significantly-enriched for both the 13C-cellulose treatment and 13C-glucose treatments relative to control (F2,72 = 1.771, p = 0.036), although cellulose and glucose treatments did not differ significantly from each other (padj = 1.000). This indicated that the fungus had not exhausted the available simple carbon sources in the medium. Means are indicated by diamonds and post-hoc groupings indicated by letters.
Fig. S2. 16S quantification using ddPCR. from A fungal symbiont converts provisioned cellulose into edible yield for its leafcutter ant farmers
Creators: name: Conlon, Benjamin H.
name: O'Tuama, David
name: Michelsen, Anders
name: Crumière, Antonin J. J.
name: Shik, Jonathan Z.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Fig.S2. The number of 16S rRNA copies in antibiotic and control treatments did not differ significantly from the negative control (F2 = 0.488, p = 0.616; Antibiotic – Negative: padj = 0.998; Control – Negative: padj = 0.909) or each other (Antibiotic – Control: padj = 0.597). There was no effect of substrate on 16S rRNA levels (F2 = 1.034, p = 0.360). Means are indicated by diamonds, the dashed line represents the gram-positive control while the solid line represents the gram-negative control.
Additional file 1: of Parental genetic material and oxygen concentration affect hatch dynamics of mouse embryo in vitro
Creators: name: Zhan, Shaoquan
name: Cao, Shanbo
name: Du, Hongzi
name: Sun, Yuan
name: Li, Li
name: Ding, Chenhui
name: Zheng, Haiyan
name: Huang, Junjiu
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health

description: Real time PCR primers for genes expression analysis of 96Â h blastocysts. (DOC 41Â kb)
Role of surgical thoracic sympathetic interruption in treatment of facial blushing: A systematic review
Creators: name: Girish Girish
name: Rovan E D’souza
name: Preethy D’souza
name: Lewis, Melissa G
name: Baker, Daryll M
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Objectives: This paper aims to review the evidence to support the effectiveness of sympathectomy as a treatment for facial blushing in terms of relief of facial blushing, patient satisfaction, recurrence of blushing, patients regretting treatment and its associated complications. Methods: A systematic search strategy was performed in Ovid-Medline, Embase, Cochrane library and NICE. Studies reporting outcomes of sympathetic interruption in the treatment of facial blushing were retrieved. Results: Nine studies met the inclusion criteria with 1369 patients included in the final analysis. The age range of patients was 8 to 74 years (from 7 studies) with 56% females. Mean follow up was 21 months in 8 studies (range 6 to 30 months). The pooled proportion of patients who had good relief of facial blushing was 78.30% (95% C.I. 58.20% – 98.39%). Complete satisfaction was reported in 84.02% (95% C.I. 71.71% – 96.33%). Compensatory sweating and gustatory sweating were the commonest complications occurring in 74.18% (95% C.I. 58.10% – 90.26%) and 24.42% (95% C.I. 12.22% – 36.61%) respectively. The estimated proportion of patients regretting surgery was 6.79% (C.I 2.08% 11.50%). Conclusion: Sympathetic interruption at T2 or T2-3 ganglia appears to be an effective treatment for facial blushing. However, lack of randomized trials comparing sympathetic interruption with non-surgical methods of treatment and heterogeneity of included studies with respect to assessment of outcome measures preclude strong evidence and definitive recommendations.
Table S1. Evidence for and against cellulose degradation, assimilation and metabolisation in Leucoagaricus gongylophorus. from A fungal symbiont converts provisioned cellulose into edible yield for its leafcutter ant farmers
Creators: name: Conlon, Benjamin H.
name: O'Tuama, David
name: Michelsen, Anders
name: Crumière, Antonin J. J.
name: Shik, Jonathan Z.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Studies on cellulose degradation since the results of Abril and Bucher (2002), which indicated Leucoagarcius gongylophorus was incapable of metabolising cellulose, and their main findings.
Multifaceted approach to home mechanical ventilation monitoring
Creators: name: Adler, Dan Elie
Publisher: name: Université de Genève
Year: 2016
Subjects: info:eu-repo/classification/ddc/616
Monitoring of home NIV

description: State-of-the-art monitoring of home NIV will be discussed first, followed by a focus on patient selection after an episode of acute respiratory failure and on new monitoring tools to adapt NIV settings. As improvements in physiological endpoints are not necessarily associated with improved, health-related, quality of life, ongoing research on NIV and quality of life will be highlighted in the perspective section.
Douleur et sensibilisation centrale : implication des voies GABAergiques et intérêt de leur modulation
Creators: name: Besson, Marie
Publisher: name: Université de Genève
Year: 2015
Subjects: info:eu-repo/classification/ddc/617
Douleur chronique
Sensibilisation centrale
Désinhibition
GABA
Benzodiazépines

description: Le concept de sensibilisation centrale permet d'expliquer l'état d'hypersensibilité douloureuse qui s'installe et perdure suite à une lésion, quelle qu'en soit son origine, au niveau du territoire lésé et/ou à distance. La sensibilisation centrale est maintenant reconnue comme un phénomène clé dans la persistance de la douleur inflammatoire, mais surtout dans la genèse et la persistance de la douleur neuropathique ou de la douleur dysfonctionnelle, terme consacré, au sens physiopathologique, pour qualifier les syndromes douloureux chroniques, voire la douleur chronique en général. La sensibilisation centrale, qui est le fait de multiples mécanismes générateurs complexes et interdépendants, peut s'envisager synthétiquement comme un découplage de la relation stimulus-réponse qui caractérise la nociception et comme un déséquilibre excitation/inhibition au sein du système nerveux central.
The influence of environmental variables on freshwater rotifers of the family Brachionidae and Lecanidae in Thailand
Creators: name: Phannee Sa-Ardrit
name: Pornsilp Pholpunthin
name: Segers, Hendrik
name: Fontaneto, Diego
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: This study investigates the influence of limnological parameters that are known to influence rotifer species richness and composition in temperate areas on two families of monogonont rotifers in a tropical area. We analysed species richness and diversity of the two families from 133 samples taken from several habitat types in Thailand. Coordinates, elevation, pH, temperature, conductivity, salinity and dissolved oxygen were measured and their effect on rotifers assessed. A total of 60 species in 5 genera was recorded from the two families. Latitude and temperature had an effect on species richness of Brachionidae. None of the variables affected species richness of Lecanidae, except habitat type, albeit not significantly. Habitat type and conductivity had an effect on species composition of the two families, whereas latitude had an effect only on species composition of Lecanidae. Species richness and composition of the two rotifer families are well documented in Thailand and no or only few additional species are expected. The limnological correlates of rotifer diversity seem to be in part comparable to and in part different from those known from temperate areas, suggesting that there may be general trends in rotifer species richness and composition across different latitudes.
pH-sensitive niosomes: Effects on cytotoxicity and on inflammation and pain in murine models
Creators: name: Rinaldi, Federica
name: Favero, Elena Del
name: Rondelli, Valeria
name: Pieretti, Stefano
name: Bogni, Alessia
name: Ponti, Jessica
name: Rossi, François
name: Marzio, Luisa Di
name: Paolino, Donatella
name: Marianecci, Carlotta
name: Carafa, Maria
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: pH-sensitive nonionic surfactant vesicles (niosomes) by polysorbate-20 (Tween-20) or polysorbate-20 derivatized by glycine (added as pH sensitive agent), were developed to deliver Ibuprofen (IBU) and Lidocaine (LID). For the physical-chemical characterization of vesicles (mean size, size distribution, zeta potential, vesicle morphology, bilayer properties and stability) dynamic light scattering (DLS), small angle X-ray scattering and fluorescence studies were performed. Potential cytotoxicity was evaluated on immortalized human keratinocyte cells (HaCaT) and on immortalized mouse fibroblasts Balb/3T3. In vivo antinociceptive activity (formalin test) and anti-inflammatory activity tests (paw edema induced by zymosan) in murine models were performed on drug-loaded niosomes. pH-sensitive niosomes were stable in the presence of 0 and 10% fetal bovine serum, non-cytotoxic and able to modify IBU or LID pharmacological activity in vivo. The synthesis of stimuli responsive surfactant, as an alternative to add pH-sensitive molecules to niosomes, could represent a promising delivery strategy for anesthetic and anti-inflammatory drugs.
Identification of glioma-associated antigens for brain tumor immunotherapy
Creators: name: Dutoit Vallotton, Valérie
Publisher: name: Université de Genève
Year: 2015
Subjects: info:eu-repo/classification/ddc/610
Glioma
Immunotherapy
Peptide vaccine
Glioma antigen

description: Glioma is a tumor occurring in the brain and one of the most devastating cancers, affecting children and young adults and having a very high morbidity with poor prognosis. The propensity of glioma cells to invade normal brain structures and to resist current treatments makes new therapeutic strategies an urgent need for this disease. Among them, tumor immunotherapy, defined as use of the immune system to fight cancer, is showing very promising results in many malignancies. The knowledge that the rules governing immune responses in other tissues are also valid for the brain has allowed development of immunotherapy for glioma. Among currently investigated glioma immunotherapies, T cell vaccines and adoptive cell therapy are restrained by the availability of tumor-derived antigens specifically expressed on tumor cells but absent, or expressed at very low levels, on normal cells, to avoid collateral damage on healthy parts of the body. Thus, for glioma, an incessant search for tumor-associated antigens has been ongoing, and we contributed to this field by identifying novel glioma-associated peptides with demonstrated presentation at the tumor cell surface, which we will present in the first part of this thesis. These results have been readily translated into clinical application via formulation of a peptide vaccine (IMA950) that is currently being tested with Poly-ICLC in grade IV glioma patients in our institution with promising results. We will present this trial and preliminary immunomonitoring data in the second part of this work. Then, to further extend the use of the IMA950 peptide vaccine to patients with less aggressive disease, who are more prone to develop clinically relevant immune responses, we assessed expression of the IMA950 antigens in a series of glioma patients with grade II and III tumors. This will be developed in the third part of this report. Finally, the discussion will integrate some early results on the effect of radiotherapy and chemotherapy on the immune system of patients, in order to understand how to better combine our vaccine with standard treatments. All in all, we will show that our research resulted in the development of a new peptide vaccine for patients with glioma, which is in clinical trial and can be proposed through all tumor grades.
MOESM3 of The role of retinoic acid signaling in starfish metamorphosis
Creators: name: Yamakawa, Shumpei
name: Morino, Yoshiaki
name: Honda, Masanao
name: Wada, Hiroshi
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 3: Table S1. Accession numbers of the gene used for construction of phylogenic tree. Amino acid sequences to construct tree were obtained from Uniprot or Echinobase ( http://www.echinobase.org/Echinobase/ ), Genbank.
Fig. S2. 16S quantification using ddPCR. from A fungal symbiont converts provisioned cellulose into edible yield for its leafcutter ant farmers
Creators: name: Conlon, Benjamin H.
name: O'Tuama, David
name: Michelsen, Anders
name: Crumière, Antonin J. J.
name: Shik, Jonathan Z.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Studies on cellulose degradation since the results of Abril and Bucher (2002), which indicated Leucoagarcius gongylophorus was incapable of metabolising cellulose, and their main findings.;Results of 16S ddPCR analysis.;Results of 13C quantification using IRMS.;The media at the end of the experimental period was still significantly-enriched for both the 13C-cellulose treatment and 13C-glucose treatments relative to control (F2,72 = 1.771, p = 0.036), although cellulose and glucose treatments did not differ significantly from each other (padj = 1.000). This indicated that the fungus had not exhausted the available simple carbon sources in the medium. Means are indicated by diamonds and post-hoc groupings indicated by letters.;Fig.S2. The number of 16S rRNA copies in antibiotic and control treatments did not differ significantly from the negative control (F2 = 0.488, p = 0.616; Antibiotic – Negative: padj = 0.998; Control – Negative: padj = 0.909) or each other (Antibiotic – Control: padj = 0.597). There was no effect of substrate on 16S rRNA levels (F2 = 1.034, p = 0.360). Means are indicated by diamonds, the dashed line represents the gram-positive control while the solid line represents the gram-negative control.
MOESM4 of The role of retinoic acid signaling in starfish metamorphosis
Creators: name: Yamakawa, Shumpei
name: Morino, Yoshiaki
name: Honda, Masanao
name: Wada, Hiroshi
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Developmental Biology
subject: Plant Biology

description: Additional file 4: Table S2. Sequences of primer for amplification of raldha, raldhb, raldhc, rar and rxr. We used 40-bp reverse primers including a 20-bp T3 promoter sequence to synthesize Dig-labelled RNA probes for in situ hybridization. Bold characters mean consensus sequence for T3 promoter.
MOESM5 of The role of retinoic acid signaling in starfish metamorphosis
Creators: name: Yamakawa, Shumpei
name: Morino, Yoshiaki
name: Honda, Masanao
name: Wada, Hiroshi
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Developmental Biology
subject: Cancer

description: Additional file 5: Table S3. Number of metamorphosed/treated larvae of each batch in ROâ +â RA treatment experiment.
MOESM6 of The role of retinoic acid signaling in starfish metamorphosis
Creators: name: Yamakawa, Shumpei
name: Morino, Yoshiaki
name: Honda, Masanao
name: Wada, Hiroshi
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Evolutionary Biology
subject: Developmental Biology
subject: Cancer

description: Additional file 6: Table S4. Number of metamorphosed/settled larvae of each batch in RO 1Â ÂľM or DMSO treatment.
MOESM7 of The role of retinoic acid signaling in starfish metamorphosis
Creators: name: Yamakawa, Shumpei
name: Morino, Yoshiaki
name: Honda, Masanao
name: Wada, Hiroshi
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 7: Table S5. Number of settled larvae/treated larvae of each batch in RO 1Â ÂľM or DMSO treatment.
MOESM8 of The role of retinoic acid signaling in starfish metamorphosis
Creators: name: Yamakawa, Shumpei
name: Morino, Yoshiaki
name: Honda, Masanao
name: Wada, Hiroshi
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 8: Table S6. Number of settled/treated larvae of each batch in DEAB 100, 300Â ÂľM or DMSO treatment.
Modeling fetal-growth biometry with Response Modeling Methodology (RMM) and comparison to current models
Creators: name: Benson-Karhi, Diamanta
name: Shore, Haim
name: Malamud, Maya
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Monitoring fetal growth via ultrasound requires modeling fetal biometry in terms of gestation age. In this study, we compare Response Modeling Methodology (RMM) to current models, in three stages. First, RMM is used to approximate 47 empirical mean models that have appeared in the literature resulting in models with negligible loss in accuracy (unlike two other commonly applied models). Next, RMM models are fitted to sample averages of the Singaporean population and compared to a formerly published model. A similar simulation-based analysis is performed in the last stage for raw data of the British population. Altogether over 70 comparisons had been performed resulting in RMM consistently delivering better performing models.
Anti-Müllerian hormone level measurement in gynaecology: Myths and clinical utility
Creators: name: Streuli, Marie Isabelle
Publisher: name: Université de Genève
Year: 2015
Subjects: info:eu-repo/classification/ddc/918
info:eu-repo/classification/ddc/618
Anti-Müllerian hormone
AMH
Contraception
Fertility
Fecundability endometriosis
Infertility
Stimulation
Assays
IVF

description: Anti-Müllerian hormone (AMH) is a glycoprotein implicated in the regulation of the pace of ovarian follicular recruitment and loss and follicle selection in adult females. AMH predicts the magnitude of the response to controlled ovarian stimulation for assisted reproductive techniques and is used to individualize treatments and avoid ovarian hyperstimulation syndrome. In contrast, AMH levels do not seem to be related to fecundability or time to pregnancy and do not predict the results intrauterine inseminations or natural cycle in vitro fertilisation. AMH fluctuates only in a minor way during the menstrual cycle allowing its measure without regard to the menstrual cycle phase. The impact of hormonal treatments such as the oral contraceptive pill is still debated. AMH levels can also be used to study the impact of medical treatments, surgical procedure or environmental factors on ovarian reserve.
MOESM9 of The role of retinoic acid signaling in starfish metamorphosis
Creators: name: Yamakawa, Shumpei
name: Morino, Yoshiaki
name: Honda, Masanao
name: Wada, Hiroshi
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: Developmental Biology
subject: Cancer

description: Additional file 9: Table S7. Number of metamorphosed/settled larvae of each batch in DEAB 100, 300Â ÂľM or DMSO treatment.
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands
Creators: name: Guariento, Sara
name: Franchini, Silvia
name: Tonelli, Michele
name: Fossa, Paola
name: Sorbi, Claudia
name: Cichero, Elena
name: Brasili, Livio
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: The 5-hydroxytryptamine (5-HT1A) receptors represent an attractive target in drug discovery. In particular, 5-HT1A agonists and partial agonists are deeply investigated for their potential role in the treatment of anxiety, depression, ischaemic brain disorder and more recently, of pain. On the other hand, 5-HT1A antagonists have been revealed promising compounds in cognition disorders and, lately, in cancer. Thus, the discovery of 5HT1A ligands is nowadays an appealing research activity in medicinal chemistry. In this work, Comparative Molecular Fields Analysis (CoMFA) and Comparative Molecular Similarity Index Analysis (CoMSIA) were applied on an in-house library of 5-HT1A ligands bearing different chemical scaffolds in order to elucidate their affinity and selectivity for the target. Following this procedure, a number of structural modifications have been drawn for the development of much more effective 5-HT1AR ligands.
MOESM1 of The role of retinoic acid signaling in starfish metamorphosis
Creators: name: Yamakawa, Shumpei
name: Morino, Yoshiaki
name: Honda, Masanao
name: Wada, Hiroshi
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 1: Figure S1. Phylogenic tree of Raldh (= Aldh1a, Aldehyde hydrogenase 1 alfa) and Aldh2 (Aldehyde hydrogenase 2) subfamily. The phylogenic tree was constructed by RAxML. raldhs of starfish made sister grouping with hemichordate aldh1as. Numbers at node show bootstrap value. The selected amino acid substation model was LG + F + G. The process to construct was described in material and method and the set of sequences is provided in Additional file 10: Supplementary dataset 1. Abbreviations of species were referred following, Hs; Homo sapiens (Human), Mm; Mus musculus (Mouse), Xt; Xenopus tropicalis (Western clawed frog), Dr; Danio rerio (Zebrafish), Bf; Branchiostoma floridae (Amphioxus), Ci; Ciona intestinalis (Transparent sea squirt), Sk; Saccoglossus kowalevskii (Acorn worm), Sp; Strongylocentrotus purpuratus (Purple sea urchin), Pp; Patiria pectinifera.
MOESM2 of The role of retinoic acid signaling in starfish metamorphosis
Creators: name: Yamakawa, Shumpei
name: Morino, Yoshiaki
name: Honda, Masanao
name: Wada, Hiroshi
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 2: Figure S2. Phylogenic tree of RAR, RXR and THR (Thyroid hormone receptor). The phylogenic tree was constructed by RAxML. The selected amino acid substation model was LG + F + G. The set of sequences is provided in Additional file 11: Supplementary dataset 2. Abbreviations of species were referred following, Hs; Homo sapiens (Human), Mm; Mus musculus (Mouse), Xt; Xenopus tropicalis (Western clawed frog), Dr; Danio rerio (Zebrafish), Bf; Branchiostoma floridae (Amphioxus), Pm; Polyandrocarpa misakiensis (Tunicate), Bl; Branchiostoma lanceolatum (Amphioxus), Ci; Ciona intestinalis (Transparent sea squirt), Sk; Saccoglossus kowalevskii (Acorn worm), Sp; Strongylocentrotus purpuratus (Purple sea urchin), Pp; Patiria pectinifera, Dm; Drosophila melanogaster (Fruit fly), Rc; Reishia clavigera (Sea snail), Ls; Lymnaea stagnalis (Great pond snail), Tc; Tripedalia cystophora (Jellyfish).
SI^2 PI Meeting Poster
Creators: name: Mandli, Kyle
name: Bienstock, Daniel
name: Miura, Yuki
name: Qureshi, Huda
name: Li, Jiao
name: Israel, Ally
name: Deodatis, George
name: Lazrus, Heather
name: Morss, Rebecca
Publisher: name: figshare
Year: 2018
Subjects: classificationCode: 461306
subject: Numerical computation and mathematical software
classificationCode: 461399
subject: Theory of computation not elsewhere classified
classificationCode: 490399
subject: Numerical and computational mathematics not elsewhere classified
classificationCode: 400599
subject: Civil engineering not elsewhere classified
classificationCode: 490108
subject: Operations research

description: Infrastructure forms the backbone of a functional and healthy community. When parts of this infrastructure is threatened, it is critical for society to respond to that threat or risk loss of life and property. One of the most significant threats to infrastructure in recent U.S. history has been the result of hurricanes, most memorably Hurricane Katrina, which devastated New Orleans, and Hurricane Sandy, which New York City infrastructure is still recovering from. Addressing these threats requires a multi-pronged approach that takes into account how infrastructure is connected and how failures in one type of infrastructure can impact the other. Questions then arise as to how we can protect ourselves from these threats. This project develops a methodology that can answer questions related to protecting this infrastructure. For instance, if a community wanted to build a sea-wall, questions such as "how high should it be?" and "where should it be placed?" must be asked. Other important questions compare a sea-wall with other protective options, such as: "Is a sea-wall the best protective measure?", "What about artificial sand dunes?", or "What about raising the infrastructure to a higher elevation?" And a related critically important question should be "Can adopting this option for protecting one community be detrimental to the safety of a neighboring community?" In addition to questions about the efficacy of protective measures, there are questions about how coastal protection may impact other coastal uses including recreational, cultural, and economic activities, and how negatively impacting these uses can be reduced while still maximizing protection. Resource constraints are also important to take into account and the question of how to optimally protect a community given constrained resources is critical. Such questions require the combination of advanced computing, mathematics and social science approaches to design tools to address these complex intersecting problems and place these tools in the hands of decision makers that need to make these types of critical decisions.
Synthesis, characterization and in vitro inhibition of metal complexes of pyrazole based sulfonamide on human erythrocyte carbonic anhydrase isozymes I and II
Creators: name: Nurgün Büyükkıdan
name: Büyükkıdan, Bülent
name: Bülbül, Metin
name: Kasımoğulları, Rahmi
name: Mert, Samet
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Sulfonamides represent an important class of biologically active compounds. A sulfonamide possessing carbonic anhydrase (CA) inhibitory properties obtained from a pyrazole based sulfonamide, ethyl 1-(3-nitrophenyl)-5-phenyl-3-((5-sulfamoyl-1,3,4-thiadiazol-2-yl)carbamoyl)-1H-pyrazole-4-carboxylate (1), and its metal complexes with the Ni(II) for (2), Cu(II) for (3) and Zn(II) for (4) have been synthesized. The structures of metal complexes (2–4) were established on the basis of their elemental analysis, 1H NMR, IR, UV–Vis and MS spectral data. The inhibition of two human carbonic anhydrase (hCA, EC 4.2.1.1) isoenzymes I and II, with 1 and synthesized complexes (2–4) and acetazolamide (AAZ) as a control compound was investigated in vitro by using the hydratase and esterase assays. The complexes 2, 3 and 4 showed inhibition constant in the range 0.1460–0.3930 µM for hCA-I and 0.0740–0.0980 µM for hCA-II, and they had effective more inhibitory activity on hCA-I and hCA-II than corresponding free ligand 1 and than AAZ.
N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors
Creators: name: Sunduru, Naresh
name: Svensson, Mona
name: Mariateresa Cipriano
name: Sania Marwaha
name: C. David Andersson
name: Svensson, Richard
name: Fowler, Christopher J.
name: Elofsson, Mikael
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Hematology

description: Fatty acid amide hydrolase (FAAH) is a promising target for the development of drugs to treat neurological diseases. In search of new FAAH inhibitors, we identified 2-(4-cyclohexylphenoxy)-N-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide, 4g, with an IC50 of 2.6 µM as a chemical starting point for the development of potent FAAH inhibitors. Preliminary hit-to-lead optimisation resulted in 2-(4-phenylphenoxy)-N-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide, 4i, with an IC50 of 0.35 µM.
An efficient synthesis method targeted to a novel aziridine derivative of p-menthane from turpentine and its herbicidal activity
Creators: name: Shou-Ji Zhu
name: Xu, Shi-Chao
name: Zhao, Zhen-Dong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Plant Biology

description: A novel aziridine compound N-acetyl-1,2-azacyclo-p-menthane d was synthesised using turpentine as raw material and characterised by FT-IR, 1H NMR, 13C NMR, ESI+-MS and HRMS. The pre-emergence herbicidal activities of d and its synthetic intermediates cis- and trans-N,N′-diacetyl-p-menthane-1,8-diamine (b2 and b1) were determined. The result showed that d exhibited much higher herbicidal activities against annual ryegrass, Digitaria sanguinalis and Ixeris denticulate than b2 and b1. The IC50 of d against the root and shoot growth of these three plants were lower than 1 mmol L−1. In contrast, the IC50 of b1 and b2 against the root and shoot growth of these plants were more than 10 mmol L−1. Transformition of turpentine into N-acetyl-1,2-azacyclo-p-menthane (d).
Additional file 1: of TaAAP6-3B, a regulator of grain protein content selected during wheat improvement
Creators: name: Jin, Xiufeng
name: Feng, Bo
name: Xu, Zhibin
name: Fan, Xiaoli
name: liu, Jing
name: Liu, Qin
name: Zhu, Ping
name: Wang, Tao
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Table S2. Primers for cloning and functional analysis of TaAAP6-3B. (DOCX 15 kb)
Modeling fetal-growth biometry with response modeling methodology (rmm) and comparison to current models
Creators: name: Benson-Karhi, Diamanta
name: Shore, Haim
name: Malamud, Maya
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Monitoring fetal growth via ultra-sound requires modeling fetal biometry in terms of gestation age. In this study we compare Response Modeling Methodology (RMM) to current models, in three stages. First, RMM is used to approximate 47 empirical mean models that have appeared in the literature resulting in models with negligible loss in accuracy (unlike two other commonly applied models). Next, RMM models are fitted to sample averages of the Singaporean population and compared to a formerly published model. A similar simulation-based analysis is performed in the last stage for raw data of the British population. Altogether over seventy comparisons had been performed resulting in RMM consistently delivering better performing models.
Additional file 1: of Chilling-induced DNA Demethylation is associated with the cold tolerance of Hevea brasiliensis
Creators: name: Tang, Xiao
name: Wang, Qichao
name: Yuan, Hongmei
name: Huang, Xi
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Figure S1. Methylated CpG island screening. Figure S2. Conversion rate of bisulfite sequencing. Figure S3. Representative Sanger sequencing chromatograms of the bisulphite-treated DNA samples of long-term cold treatment. Figure S4. Graphical representation of methylation patterns of three gene promoters altered by long-term cold treatment. Table S1. List of the primers for Quantitative real-time PCR. Table S2. List of the primers for PCR amplification of genes promoters. Table S3. Cis-elements existing in promoters of pHbICE1, pHbCBF2 and pHbMET. (DOCX 1845 kb)
Classical and new markers of chronic kidney disease
Creators: name: Ponte, Belen
Publisher: name: Université de Genève
Year: 2016
Subjects: info:eu-repo/classification/ddc/616

description: Chronic kidney disease (CKD) is a leading cause of morbidity and mortality worldwide. Definition is based on the estimation of the glomerular filtration rate by different equations using the serum creatinine or albuminuria. Those are considered as classical markers of kidney function. Renal ultrasound is also a tool to detect kidney disease either by identifying some structural anomaly or by indicating increased renal resistive indexes using the doppler. Finally other markers can add information on kidney disease by indicating pathological pathways instead of simply providing information on the glomerular filtration rate. In this thesis, we presented the prevalence and determinants of CKD in Switzerland. We also provided references values and determinants for renal length and renal resistive index measured by the ultrasound. We finally analysed some markers of the kidney function focusing on (i) the mineral metabolism, (ii) water balance and (iii) tubular function by studying FGF23, copeptin and uromodulin, respectively.
Additional file 1: of Effects of drought stress and water recovery on physiological responses and gene expression in maize seedlings
Creators: name: Zhang, Xiangbo
name: Lei, Lei
name: Lai, Jinsheng
name: Zhao, Haiming
name: Song, Weibin
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Plant Biology

description: Premiers used in the validation of RNA-seq data by means of qRT-PCR. (PDF 99Â kb)
Towards quantitative multimodality imaging in the planning, quality control, dosimetry and response assessment of therapy in oncologic and non oncologic diseases
Creators: name: Wissmeyer, Michael
Publisher: name: Université de Genève
Year: 2016
Subjects: info:eu-repo/classification/ddc/616.0757
Quantitative
Multimodality
Imaging
Parametric
PET/CT
SPECT/CT
PET/MRI
Ultrasound

description: Qualitative and quantitative multimodality imaging play a more and more important role in the planning, quality control, and assessment of response in many oncologic and non oncologic diseases. Before hybrid modalities such as SPECT/CT, PET/CT and, most recently, PET/MRI, became available, the images from the different modalities were analyzed independently or by software fusion. Nowadays, these images are most frequently acquired on hybrid modalities, allowing for so called "one-stop-shop" investigations. Depending on a static or a dynamic image acquisition, either semi or fully quantitative measurements of both structural and functional parameters are possible, allowing for multi-parametric image analysis. These qualitative and quantitative parameters can then be used for detection and assessment of extension of disease as well as for planning of therapeutic interventions or, even more interesting, for quality control, dosimetry of radionuclide therapies, assessment of response to treatment and, finally, prediction of outcome of the patients. This thesis discusses the qualitative and quantitative imaging and quantification methods available today and their potential future impact in research and clinical decision making.
Additional file 1: of Dose effects of mycophenolate mofetil in Chinese patients with neuromyelitis optica spectrum disorders: a case series study
Creators: name: Jiao, Yujuan
name: Cui, Lei
name: Zhang, Weihe
name: Zhang, Chunyu
name: Zhang, Yeqiong
name: Zhang, Xin
name: Jiao, Jinsong
Publisher: name: figshare
Year: 2018
Subjects: Medicine
Pharmacology
Marine Biology
Science Policy
Mental Health

description: Table S1. Baseline demographic and clinical data of NMOSD patients receiving different dosages of MMF. There was no significant difference in baseline demographic and clinical data among the 3 groups of the NMOSD patients receiving different dosages of MMF. (DOC 41 kb)