cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Relugolix/Estradiol/Norethisterone Acetate: A Review in Endometriosis-Associated Pain
Creators: name: Blair, Hannah A.
Publisher: name: Adis Journals
Year: 2024
Subjects: Medicine

description: Declarations
Funding The preparation of this review was not supported by any external funding.
Authorship and Conflict of interest Hannah A. Blair is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to this article and are responsible for its content.

Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability Not applicable.

Additional information about this Adis Drug Review can be found here. 

Abstract
An oral fixed-dose combination of relugolix/estradiol/norethisterone (also known as norethindrone) acetate [Myfembree® (USA); Ryeqo® (EU)] (hereafter referred to as relugolix combination therapy) has been approved in the USA for the management of moderate to severe pain associated with endometriosis in premenopausal women and in the EU for the symptomatic treatment of endometriosis in adult women of reproductive age with a history of previous medical or surgical treatment for their endometriosis. The gonadotropin-releasing hormone (GnRH) receptor antagonist relugolix decreases estradiol and progesterone levels, while the addition of estradiol/norethisterone acetate mitigates hypoestrogenic effects including bone mineral density (BMD) loss and vasomotor symptoms. In two pivotal phase III trials, relugolix combination therapy significantly improved dysmenorrhoea and non-menstrual pelvic pain in premenopausal women with moderate to severe endometriosis. The combination also reduced overall pelvic pain and dyspareunia, reduced analgesic and opioid use, and improved health-related quality of life. The efficacy of relugolix combination therapy was sustained over the longer term (up to 2 years). Relugolix combination therapy was generally well tolerated and BMD loss over time was minimal. With the convenience of a once daily oral dosing regimen, relugolix combination therapy is a valuable addition to the options currently available for the management of endometriosis-associated pain.

  
© Springer Nature Switzerland AG 2024
Correlations and the Dirac Structure of the Nucleon Self-Energy
Creators: name: Schiller, E.
name: Müther, H.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The Dirac structure of the nucleon self-energy in symmetric nuclear matter as well as neutron matter is derived from a realistic meson exchange model for the nucleon-nucleon (NN) interaction. It is demonstrated that the effects of correlations on the effective NN interaction in the nuclear medium can be parameterized by means of an effective meson exchange. This analysis leads to a very intuitive interpretation of correlation effects and also provides an efficient parametrization of an effective interaction to be used in relativistic structure calculations for finite nuclei.
description: 16 pages, 11 Figures included
Non Existence of Non-trivial Solutions to the Diophantine Equation $Ax^{p} \pm By^{q}=Cz^{r}$
Creators: name: Daras, Nicholas J.
Publisher: name: Zenodo
Year: 2019
Subjects: Diophantine equation, Generalized Fermat equation, Beal's Conjecture, Dirichlet's Theorem on arithmetic progressions, Bezout's Identity, greatest common divisor

description: Weprove that there is no non-trivial solution to the Diophantine equation Ax^p+By^q=Cz^r provided that min{p,q,r}>2 and gcd(Ax, By,Cz)=1. In particular, we reaffirm Beal's
title: ESLO1: contact avant entretien 203_B
Creators: name: Laboratoire Ligérien De Linguistique
name: Baude, Olivier
name: Dugua, Céline
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015
Subjects: subject: Français
subject: fra
subject: text_and_corpus_linguistics

description: Extrait du corpus d'Orléans, réalisé dans le cadre de l'Enquête SocioLinguistique à Orléans à la fin des années 1960.
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
Additional file 1 of The effects of social networks on HIV risk behaviors among Vietnamese female sex workers: a qualitative study
Creators: name: Zhou, LongHui
name: Liu, Yi
name: Liu, Dan
name: Xiao, ChenChang
name: Li, JiaYu
name: Zhai, MengXi
name: liu, Xin
name: Yu, Bin
name: Yan, Hong
Publisher: name: figshare
Year: 2024
Subjects: subject: Sociology
subject: FOS: Sociology

description: Additional file 1: Interview outline.
A mycorrhiza-associated receptor-like kinase with an ancient origin in the green lineage.
Creators: name: Montero, Héctor
name: Lee, Tak
name: Pucker, Boas
name: Ferreras-Garrucho, Gabriel
name: Oldroyd, Giles
name: Brockington, Samuel F
name: Miyao, Akio
name: Paszkowski, Uta
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Arbuscular mycorrhiza
Osark2
Spark Receptor-like Kinases

description: Receptor-like kinases (RLKs) are key cell signaling components. The rice ARBUSCULAR RECEPTOR-LIKE KINASE 1 (OsARK1) regulates the arbuscular mycorrhizal (AM) association postarbuscule development and belongs to an undefined subfamily of RLKs. Our phylogenetic analysis revealed that ARK1 has an ancient paralogue in spermatophytes, ARK2 Single ark2 and ark1/ark2 double mutants in rice showed a nonredundant AM symbiotic function for OsARK2 Global transcriptomics identified a set of genes coregulated by the two RLKs, suggesting that OsARK1 and OsARK2 orchestrate symbiosis in a common pathway. ARK lineage proteins harbor a newly identified SPARK domain in their extracellular regions, which underwent parallel losses in ARK1 and ARK2 in monocots. This protein domain has ancient origins in streptophyte algae and defines additional overlooked groups of putative cell surface receptors.
Hosts elevate either within-clutch consistency or between-clutch distinctiveness of egg phenotypes in defence against brood parasites.
Creators: name: Caves, Eleanor M
name: Dixit, Tanmay
name: Colebrook-Robjent, John F R
name: Hamusikili, Lazaro
name: Stevens, Martin
name: Thorogood, Rose
name: Spottiswoode, Claire N
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Coevolution
Host Defence
Avian Brood Parasitism
Egg Colour
Egg Pattern
Egg Signatures

description: In host-parasite arms races, hosts can evolve signatures of identity to enhance the detection of parasite mimics. In theory, signatures are most effective when within-individual variation is low ('consistency'), and between-individual variation is high ('distinctiveness'). However, empirical support for positive covariation in signature consistency and distinctiveness across species is mixed. Here, we attempt to resolve this puzzle by partitioning distinctiveness according to how it is achieved: (i) greater variation within each trait, contributing to elevated 'absolute distinctiveness' or (ii) combining phenotypic traits in unpredictable combinations ('combinatorial distinctiveness'). We tested how consistency covaries with each type of distinctiveness by measuring variation in egg colour and pattern in two African bird families (Cisticolidae and Ploceidae) that experience mimetic brood parasitism. Contrary to predictions, parasitized species, but not unparasitized species, exhibited a negative relationship between consistency and combinatorial distinctiveness. Moreover, regardless of parasitism status, consistency was negatively correlated with absolute distinctiveness across species. Together, these results suggest that (i) selection from parasites acts on how traits combine rather than absolute variation in traits, (ii) consistency and distinctiveness are alternative rather than complementary elements of signatures and (iii) mechanistic constraints may explain the negative relationship between consistency and absolute distinctiveness across species.
The ESO SupJup Survey VII: Clouds and line asymmetries in CRIRES$^+$ J-band spectra of the Luhman 16 binary
Creators: name: de Regt, S.
name: Snellen, I. A. G.
name: Allard, N. F.
name: Picos, D. González
name: Gandhi, S.
name: Grasser, N.
name: Landman, R.
name: Mollière, P.
name: Nasedkin, E.
name: Stolker, T.
name: Zhang, Y.
Publisher: name: arXiv
Year: 2025
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Brown dwarfs at the L-T transition likely experience an inhomogeneous clearing of the clouds in their atmospheres. The resulting surface of thin and thick cloudy patches has been put forward to explain the observed variability, J-band brightening, and re-emergence of FeH absorption. We study the closest brown dwarf binary, Luhman 16A and B, in an effort to constrain their chemical and cloud compositions. As this binary consists of an L7.5 and T0.5 component, we gain insight into the atmospheric properties at the L-T transition. As part of the ESO SupJup Survey, we observed Luhman 16AB at high spectral resolution in the J-band ($1.1-1.4\ \mathrm{μm}$) using CRIRES$^+$. To analyse the spectra, we employ an atmospheric retrieval framework, coupling the radiative transfer code petitRADTRANS with the MultiNest sampling algorithm. For both objects, we report detections of H$_2$O, K, Na, FeH, and, for the first time in the J-band, hydrogen-fluoride (HF). The K doublet at $1250\ \mathrm{nm}$ shows asymmetric absorption in the blue line wings, which are reproduced via pressure- and temperature-dependent shifts of the line cores. We find evidence for clouds in both spectra and we place constraints on an FeH-depletion in the Luhman 16A photosphere. The inferred over-abundance of FeH for Luhman 16B opposes its predicted rainout into iron clouds. A two-column model, which emulates the patchy surface expected at the L-T transition, is weakly preferred ($\sim 1.8σ$) for component B but disfavoured for A ($\sim 5.5σ$). The results suggest a uniform surface on Luhman 16A, which is in good agreement with the reduced variability observed for this L-type component. While the presented evidence is not sufficient to draw conclusions about any inhomogeneity on Luhman 16B, future observations covering a broader wavelength range could help to test the cloud-clearing hypothesis.
description: Accepted for publication in A&A
Additional files 3: of Genetic polymorphism in Leishmania infantum isolates from human and animals determined by nagt PCR-RFLP
Creators: name: Hamouchi, Adil El
name: Kacem, Sofia El
name: Rajaa Ejghal
name: Lemrani, Meryem
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Table S2. Cut positions of restriction enzymes tested by in-silico digestion of nagt (1405 bp) of L. infantum JPCM5. (DOCX 12 kb)
Small-Angle Bhabha Scattering at LEP1. Analytical Results for Wide-Narrow Angular Acceptance
Creators: name: Arbuzov, A. B.
name: Gach, G. I.
name: Gontchar, V. Yu.
name: Kuraev, E. A.
name: Merenkov, N. P.
name: Trentadue, L.
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Analytical formulae for small-angle Bhabha scattering cross-section at LEP1 are given for the case of wide-narrow angular acceptance. Inclusive and calorimeter event selections are considered. Numerical results are presented.
description: 13 pages, LaTeX, submitted to Phys. Lett. B, corrected according to referee remarks
title: ESLO1: contact avant entretien 202_B
Creators: name: Laboratoire Ligérien De Linguistique
name: Baude, Olivier
name: Dugua, Céline
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015
Subjects: subject: Français
subject: fra
subject: text_and_corpus_linguistics

description: Extrait du corpus d'Orléans, réalisé dans le cadre de l'Enquête SocioLinguistique à Orléans à la fin des années 1960.
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
Nucleosynthesis in Chandrasekhar Mass Models for Type Ia Supernovae and Constraints on Progenitor Systems and Burning-Front Propagation
Creators: name: Iwamoto, K.
name: Brachwitz, F.
name: Nomoto, K.
name: Kishimoto, N.
name: Umeda, H.
name: Hix, W. R.
name: Thielemann, F. -K.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We calculate explosive nucleosynthesis in Chandrasekhar mass models for Type Ia Supernovae(SNe Ia) to obtain new constraints on the rate of matter accretion onto the progenitor white dwarf and on the ignition density of central carbon deflagration. The calculated abundance of the Fe-group neutron-rich nuclei is highly sensitive to the electron captures taking place in the central layers. The yields obtained from a slow central deflagration, and from a fast deflagration or delayed detonation in the outer layers, are combined and put to comparison with solar isotopic abundances. We found that (1) to avoid too large ratios of $^{54}$Cr/$^{56}$Fe and $^{50}$Ti/$^{56}$Fe, the ignition density should be as low as \ltsim 2 \e9 \gmc, and that (2) to avoid the overproduction of $^{58}$Ni and $^{54}$Fe, either the flame speed should not exceed a few % of the sound speed in the central low $Y_e$ layers, or the progenitor star has to be metal-poor compared with solar. Such low central densities can be realized by a rapid accretion as fast as $\dot M$ \gtsim 1 $\times$ 10$^{-7}$M$_\odot$ yr$^{-1}$. In order to reproduce the solar abundance of $^{48}$Ca, one also needs progenitor systems that undergo ignition at higher densities. We also found that the total amount of $^{56}$Ni, the Si-Ca/Fe ratio, and the abundance of elements like Mn and Cr (incomplete Si-burning ashes), depend on the density of the deflagration-detonation transition in delayed detonations. Our nucleosynthesis results favor transition densities slightly below 2.2$\times 10^7$ g cm$^{-3}$.
Actio causes reactio: Gravito-optical trapping of three-level atoms
Creators: name: Marzlin, Karl-Peter
name: Audretsch, Jürgen
Publisher: name: arXiv
Year: 1996
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We investigate an atomic three-level $Λ$-system which is exposed to two counterpropagating laser fields (inducing Raman transitions) and which is closed by a magnetic hyperfine field tuned to be in resonance with the transition between the two ground states. The influence of a homogeneous gravitational field is included in a full quantum treatment of the internal and external dynamics of the atom. It is shown that the combined influence of the gravitational field and the lasers lead for specific momentum values with a very high probability to a transition of the Landau-Zener type. This is accompanied by a momentum transfer resulting in an upward kick. For appropriate initial conditions a sequence of up and down motions is obtained. No mirror is needed. A gravito-optical trapping of atoms based on this effect seems to be realizable.
description: 12 Pages, Latex, includes 3 figures. To appear in Phys. Rev. A
Additional file 1 of Co-expression of IL-21-Enhanced NKG2D CAR-NK cell therapy for lung cancer
Creators: name: Zhang, Yan
name: Zhang, Cong
name: He, Minghong
name: Xing, Weipeng
name: Hou, Rui
name: Zhang, Haijin
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 1
Consistent oviposition preferences of the Duke of Burgundy butterfly over 14 years on a chalk grassland reserve in Bedfordshire, UK
Creators: name: Hayes, M. P.
name: Ashe-Jepson, E.
name: Hitchcock, G. E.
name: Knock, R. I.
name: Lucas, C. B. H.
name: Bladon, A. J.
name: Turner, E. C.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Original Paper
Butterfly
Calcareous grassland
Climate change
Habitat management
Hamearis lucina
Oviposition

description: Funder: Christ's College, University of Cambridge (GB)
description: Funder: Isaac Newton Trust; doi: http://dx.doi.org/10.13039/501100004815
description: Funder: Museums Association and Esmée Fairbairn Collections Fund (GB)
description: Abstract: The Duke of Burgundy butterfly (Hamearis lucina) is known to have specific habitat requirements for its larval foodplants. However, no studies have yet investigated whether these preferences vary over time or in relation to climate, and there is a paucity of data on whether management on reserves can replicate preferred conditions. Here, we build upon existing research to confirm which characteristics Duke of Burgundy prefer for their larval foodplants, whether preferences remain consistent across years, and whether conservation management on reserves can replicate these conditions. Fieldwork was carried out at Totternhoe Quarry Reserve, a chalk grassland site in Bedfordshire, UK. Confirming previous research, we found that large Primula plants in dense patches were chosen for oviposition, but that once chosen there was no preference to lay eggs on a plant’s largest leaf. Chosen foodplants were also more sheltered and in closer proximity to scrub than their controls. However, at a finer scale, we found little evidence for any preference based on differences in microclimate, or vegetation height immediately surrounding the plants. This suggests features that alter microclimatic conditions at a larger scale are relatively more important for determining the suitability of oviposition sites. Nearly all preferences remained consistent over time and did not vary between years. Management of scrub on the reserve was able to reproduce some preferred habitat features (high plant density), but not others (large plant size). Implications for insect conservation: The consistency of findings across years, despite inter-annual variation in temperature, rainfall and number of adults, indicates that the Duke of Burgundy is conservative in its foodplant choice, highlighting its need for specific habitat management. Targeted management for foodplants could form part of a tractable set of tools to support Duke of Burgundy numbers on reserves, but a careful balance is needed to avoid scrub clearance leaving plants in sub-optimal conditions.
title: ESLO1: contact avant entretien 201_B
Creators: name: Laboratoire Ligérien De Linguistique
name: Baude, Olivier
name: Dugua, Céline
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015
Subjects: subject: Français
subject: fra
subject: text_and_corpus_linguistics

description: Extrait du corpus d'Orléans, réalisé dans le cadre de l'Enquête SocioLinguistique à Orléans à la fin des années 1960.
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
Tagging a jet from a dark sector with Jet-substructures at colliders
Creators: name: Park, Myeonghun
name: Zhang, Mengchao
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The phenomenology of dark sector is complicated if dark sector is charged under a confined hidden gauge group. In such kind of model, a dark parton produced at a high energy collider showers and hadronize to a cluster of dark mesons. Dark mesons then decay to visible particles and produce a jet-like signal, which is called "dark jet" in this work. Collider signal of dark jet depends on the property of dark mesons. For example, a finite lifetime of dark meson would provide displaced vertex or displaced track, thus one can use these displaced objects to tag dark jet. However if the lifetime of dark meson is collider-negligible (too short to manifest a displaced vertex), it would be difficult to distinguish a dark jet from SM QCD jets. In this work we propose a new tagging strategy to identify dark jets from QCD backgrounds. This strategy is based on jet-substructure analysis. We study various jet-substructure variables and find out variables with good discrimination ability. Our result shows that by combining multiple jet-substructure variables, one could distinguish dark jets from QCD background, and thus enhance the sensitivity of dark sector search at collider.
description: Published version
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7.
Creators: name: Meng, Bo
name: Kemp, Steven A
name: Papa, Guido
name: Datir, Rawlings
name: Ferreira, Isabella A T M
name: Marelli, Sara
name: Harvey, William T
name: Lytras, Spyros
name: Mohamed, Ahmed
name: Gallo, Giulia
name: Thakur, Nazia
name: Collier, Dami A
name: Mlcochova, Petra
name: Duncan, Lidia M
name: Carabelli, Alessandro M
name: Kenyon, Julia C
name: Lever, Andrew M
name: De Marco, Anna
name: Saliba, Christian
name: Culap, Katja
name: Cameroni, Elisabetta
name: Matheson, Nicholas J
name: Piccoli, Luca
name: Corti, Davide
name: James, Leo C
name: Robertson, David L
name: Bailey, Dalan
name: Gupta, Ravindra K
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Resistance
Deletion
Infectivity
Neutralizing Antibodies
Antibody Escape
Covid-19
Sars-cov-2
B.1.1.7
Spike Mutation
Alpha Variant
Cell Line
Vero Cells
Animals
Humans
Recurrence
Antibodies, Viral
Phylogeny
Protein Binding
Mutation
Immune Evasion
Antibodies, Neutralizing
HEK293 Cells
Pandemics
Spike Glycoprotein, Coronavirus
Chlorocebus aethiops
COVID-19
SARS-CoV-2

description: Funder: Wellcome Trust
description: We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase binding affinity to the ACE2 receptor and confer antibody escape. In vitro, we show that, although ΔH69/V70 itself is not an antibody evasion mechanism, it increases infectivity associated with enhanced incorporation of cleaved spike into virions. ΔH69/V70 is able to partially rescue infectivity of spike proteins that have acquired N439K and Y453F escape mutations by increased spike incorporation. In addition, replacement of the H69 and V70 residues in the Alpha variant B.1.1.7 spike (where ΔH69/V70 occurs naturally) impairs spike incorporation and entry efficiency of the B.1.1.7 spike pseudotyped virus. Alpha variant B.1.1.7 spike mediates faster kinetics of cell-cell fusion than wild-type Wuhan-1 D614G, dependent on ΔH69/V70. Therefore, as ΔH69/V70 compensates for immune escape mutations that impair infectivity, continued surveillance for deletions with functional effects is warranted.
Asymmetric accretion through a streamer onto the pre-stellar core H-MM1
Creators: name: Choudhury, Spandan
name: Kim, Jongsoo
name: Caselli, Paola
name: Lee, Chang Won
name: Pineda, Jaime E.
Publisher: name: arXiv
Year: 2025
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: CONTEXT: Dense cores are thought to be isolated from the surrounding cloud. However, observations of streamers and subsonic material outside core boundaries challenges this idea. AIMS: In this study, we aim to probe the extended subsonic region observed around the pre-stellar core H-MM1 in L1688 using multi-component kinematical analysis of very high-sensitivity NH3 data. METHODS: We used observations of NH3 (1,1) and (2,2) using GBT. We then fitted up to two components towards the core and its surrounding molecular cloud. RESULTS: We detect an extended region of subsonic turbulence in addition to the ambient cloud, which show supersonic turbulence. This extended subsonic region is approximately 12 times the size of and more than two times as massive as the previously detected subsonic material. The subsonic region is further split into two well-separated, velocity-coherent components, one of which is kinematically and spatially connected to the dense core. The two subsonic components are red- and blue-shifted with respected to the cloud component. We also detect a flow of material onto the dense core from the extended subsonic region via a streamer of length ~0.15 pc (~30000 au). CONCLUSIONS: We find that the extended subsonic component kinematically associated with the dense core contains 27% more mass than the core. This material could be further accreted by the core. The other subsonic component contains a mass similar to that of the core mass, and could be tracing material in the early stage of core formation. The H-MM1 streamer is kinematically similar to the ones observed towards protostellar systems, but is the first instance of such an accretion feature onto a core in its pre-stellar phase. This accretion of chemically fresh material by the pre-stellar core challenges our current understanding of a core evolving with a mass unchanged since the time of its formation.
description: 10 pages, 8 figures, accepted for publication on Astronomy and Astrophysics. The scripts used for the analysis presented in this paper can be found at https://github.com/SpandanCh/H-MM1_extended_subsonic (Language edits from previous version)
Additional file 1 of Incidence, risk factors and maternal outcomes of unsuspected placenta accreta spectrum disorders: a retrospective cohort study
Creators: name: Zhao, Jianlin
name: Li, Qin
name: Liao, E
name: Shi, Haijun
name: Luo, Xin
name: Zhang, Lan
name: Qi, Hongbo
name: Zhang, Hua
name: Li, Junnan
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Cell Biology
Pharmacology
Biotechnology
Mathematical Sciences not elsewhere classified

description: Supplementary Material 1
title: The appropriation and circulation of evolutionary science in the contemporary US and English-speaking manosphere
Creators: name: Bachaud, Louis
Publisher: name: University of Kent
Year: 2025

description: The manosphere is a collection of antifeminist men's groups. They are united by their enthusiasm for Darwinian evolution, especially around issues of sex differences. This research examines manosphere appropriations of evolutionary science from three angles. Firstly, it assesses the scientific literacy of manospherians with a survey, revealing relatively high levels of college science education and scientific literacy. Secondly, through qualitative discourse analysis, it thoroughly reviews the appropriations of evolutionary science found in the manosphere. Overall, manospherians tend to disproportionately apply biological theories to women, making for a uniform and strongly deterministic view of female behavior. Moreover, they also create their own evolutionary hypotheses to make sense of the world through a Darwinian lens. Yet, appropriations of evolutionary science vary between manosphere communities, depending on their political aims and narratives. Running through all these appropriations however is a presence of misogynistic biases, as well as exaggeration and simplification of academic research results. To understand this phenomenon better, this work finally explores scientific knowledge circulation and acquisition in the manosphere.
Additional file 2: of High-resolution profiles of the Streptococcus mitis CSP signaling pathway reveal core and strain-specific regulated genes
Creators: name: G. Salvadori
name: R. Junges
name: H. Åmdal
name: T. Chen
name: D. Morrison
name: F. Petersen
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: Table S2. Type strain genes up and downregulated (> 2-fold) in response to CSP in C + YYB. (DOCX 19 kb)
Gauge and Yukawa coupling beta functions of two-Higgs-doublet models to three-loop order
Creators: name: Herren, Florian
name: Mihaila, Luminita
name: Steinhauser, Matthias
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We compute the beta functions for the three gauge couplings and the Yukawa matrices of a general two-Higgs-doublet model in the modified minimal subtraction scheme to three loops. The calculations are performed using Lorenz gauge in the unbroken phase. We discuss in detail the occurence of poles in anomalous dimensions and propose practical prescriptions to avoid them. We provide explicit results for the often used $\mathbb{Z}_2$-symmetric versions of the two-Higgs-doublet model of type I, II, X and Y. Furthermore, we provide the first independent cross-check of the three-loop Yukawa coupling beta functions of the Standard Model.
description: 29 pages, 2 figures; v2: typos in eqs. (44) and (45) fixed
Ёшларимиз таълим-тарбиясида оиланинг ўрни
Creators: name: Бейсенов Кенжабай Сарсанбаевич, Меликулов Нуржов Латифович
Publisher: name: Zenodo
Year: 2024

description: Аннотация: мақолада ёшларимиз таълим-тарбиясида оиланинг ўрни тўғрисида маълумотлар қайд этилган.

Аннотация: В статье отмечена информация о роли семьи в образовании и воспитании нашей молодежи.

Аннотатион: the article records information about the role of the family in the education of our young people.

 

Таянч сўзлар: оила, ота-она, бола, никоҳ, тарбия, дастур.

 Базовые слова: семья, родители, ребенок, брак, воспитание, программа.

Басе wордс: family, parent, child, marriage, upbringing, program.
Discovery of a Color-Selected Quasar at z=5.50
Creators: name: Stern, Daniel
name: Spinrad, Hyron
name: Eisenhardt, Peter
name: Bunker, Andrew J.
name: Dawson, Steve
name: Stanford, S. A.
name: Elston, Richard
Publisher: name: arXiv
Year: 2000
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present observations of RD J030117+002025, a quasar at z=5.50 discovered from deep, multi-color, ground-based observations covering 74 square arcmin. This is the most distant quasar or AGN currently known. The object was targeted as an R-band dropout, with R(AB)>26.3 (3-sigma limit in a 3 arcsec diameter region), I(AB)=23.8, and z(AB)=23.4. The Keck/LRIS spectrum shows broad Lyman-alpha/NV emission and sharp absorption decrements from the highly-redshifted hydrogen forests. The fractional continuum depression due to the Lyman-alpha forest is D(A)=0.90. RD J030117+002025 is the least luminous, high-redshift quasar known (M(B)~-22.7).
description: 9 pages, 2 figures; to appear in the The Astrophysical Journal Letters
Single cell derived mRNA signals across human kidney tumors.
Creators: name: Young, Matthew D
name: Mitchell, Thomas J
name: Custers, Lars
name: Margaritis, Thanasis
name: Morales-Rodriguez, Francisco
name: Kwakwa, Kwasi
name: Khabirova, Eleonora
name: Kildisiute, Gerda
name: Oliver, Thomas R W
name: De Krijger, Ronald R
name: Van Den Heuvel-Eibrink, Marry M
name: Comitani, Federico
name: Piapi, Alice
name: Bugallo-Blanco, Eva
name: Thevanesan, Christine
name: Burke, Christina
name: Prigmore, Elena
name: Ambridge, Kirsty
name: Roberts, Kenny
name: Braga, Felipe A Vieira
name: Coorens, Tim H H
name: Del Valle, Ignacio
name: Wilbrey-Clark, Anna
name: Mamanova, Lira
name: Stewart, Grant D
name: Gnanapragasam, Vincent J
name: Rampling, Dyanne
name: Sebire, Neil
name: Coleman, Nicholas
name: Hook, Liz
name: Warren, Anne
name: Haniffa, Muzlifah
name: Kool, Marcel
name: Pfister, Stefan M
name: Achermann, John C
name: He, Xiaoling
name: Barker, Roger A
name: Shlien, Adam
name: Bayraktar, Omer A
name: Teichmann, Sarah A
name: Holstege, Frank C
name: Meyer, Kerstin B
name: Drost, Jarno
name: Straathof, Karin
name: Behjati, Sam
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Kidney
Fetus
Humans
Kidney Neoplasms
RNA, Messenger
Signal Transduction
Gene Expression Regulation, Developmental
Algorithms
Models, Genetic
Adult
Child
Single-Cell Analysis
Transcriptome
RNA-Seq

description: Funder: Department of Health
description: Tumor cells may share some patterns of gene expression with their cell of origin, providing clues into the differentiation state and origin of cancer. Here, we study the differentiation state and cellular origin of 1300 childhood and adult kidney tumors. Using single cell mRNA reference maps of normal tissues, we quantify reference "cellular signals" in each tumor. Quantifying global differentiation, we find that childhood tumors exhibit fetal cellular signals, replacing the presumption of "fetalness" with a quantitative measure of immaturity. By contrast, in adult cancers our assessment refutes the suggestion of dedifferentiation towards a fetal state in most cases. We find an intimate connection between developmental mesenchymal populations and childhood renal tumors. We demonstrate the diagnostic potential of our approach with a case study of a cryptic renal tumor. Our findings provide a cellular definition of human renal tumors through an approach that is broadly applicable to human cancer.
Deep Inelastic Scattering with Tagged Photons at HERA
Creators: name: Bardin, D.
name: Kalinovskaya, L.
name: Riemann, T.
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We calculate cross-sections for neutral current deep inelastic scattering at HERA with photon tagging. Both the exact lowest-order cross-section and a leading logarithmic approximation of next-order corrections are calculated. The latter amounts to less than 20% in a large kinematical range. The integrations are performed numerically but without relying on Monte Carlo methods.
description: 25 pages, LaTex, 9 figures; uses bezier.sty and epsfig.sty
Analysis of the low-energy $η$NN-dynamics within a three-body formalism
Creators: name: Fix, A.
name: Arenhoevel, H.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The interaction of an $η$-meson with two nucleons is studied within a three-body approach. The major features of the $ηNN$-system in the low-energy region are accounted for by using a s-wave separable ansatz for the two-body $ηN$- and $NN$-amplitudes. The calculation is confined to the $(J^π;T)=(0^-;1)$ and $(1^-;0)$ configurations which are assumed to be the most promising candidates for virtual or resonant $ηNN$-states. The eigenvalue three-body equation is continued analytically into the nonphysical sheets by contour deformation. The position of the poles of the three-body scattering matrix as a function of the $ηN$-interaction strength is investigated. The corresponding trajectory, starting on the physical sheet, moves around the $ηNN$ three-body threshold and continues away from the physical area giving rise to virtual $ηNN$-states. The search for poles on the nonphysical sheets adjacent directly to the upper rim of the real energy axis gives a negative result. Thus no low-lying s-wave $ηNN$-resonances were found. The possible influence of virtual poles on the low-energy $ηNN$-scattering is discussed.
description: 16 pages revtex including 10 figures
Runaway of Line-Driven Winds Towards Critical and Overloaded solutions
Creators: name: Feldmeier, Achim
name: Shlosman, Isaac
Publisher: name: arXiv
Year: 2000
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Line-driven winds from hot stars and accretion disks are thought to adopt a unique, critical solution which corresponds to maximum mass loss rate and a particular velocity law. We show that in the presence of negative velocity gradients, radiative-acoustic (Abbott) waves can drive shallow wind solutions towards larger velocities and mass loss rates. Perturbations introduced downstream from the wind critical point lead to convergence towards the critical solution. By contrast, low-lying perturbations cause evolution towards a mass-overloaded solution, developing a broad deceleration region in the wind. Such a wind differs fundamentally from the critical solution. For sufficiently deep-seated perturbations, overloaded solutions become time-dependent and develop shocks and shells.
description: Latex, 2 postscript figures Astrophysical Journal Letters, in press
Sensing and seeing associated with overlapping occipitoparietal activation in simultaneous EEG-fMRI.
Creators: name: Scrivener, Catriona L
name: Malik, Asad
name: Lindner, Michael
name: Roesch, Etienne B
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Conscious Awareness
Change Blindness
Sensing
Eeg-fmri

description: The presence of a change in a visual scene can influence brain activity and behavior, even in the absence of full conscious report. It may be possible for us to sense that such a change has occurred, even if we cannot specify exactly where or what it was. Despite existing evidence from electroencephalogram (EEG) and eye-tracking data, it is still unclear how this partial level of awareness relates to functional magnetic resonance imaging (fMRI) blood oxygen level dependent (BOLD) activation. Using EEG, fMRI, and a change blindness paradigm, we found multi-modal evidence to suggest that sensing a change is distinguishable from being blind to it. Specifically, trials during which participants could detect the presence of a colour change but not identify the location of the change (sense trials), were compared to those where participants could both detect and localise the change (localise or see trials), as well as change blind trials. In EEG, late parietal positivity and N2 amplitudes were larger for localised changes only, when compared to change blindness. However, ERP-informed fMRI analysis found no voxels with activation that significantly co-varied with fluctuations in single-trial late positivity amplitudes. In fMRI, a range of visual (BA17,18), parietal (BA7,40), and mid-brain (anterior cingulate, BA24) areas showed increased fMRI BOLD activation when a change was sensed, compared to change blindness. These visual and parietal areas are commonly implicated as the storage sites of visual working memory, and we therefore argue that sensing may not be explained by a lack of stored representation of the visual display. Both seeing and sensing a change were associated with an overlapping occipitoparietal network of activation when compared to blind trials, suggesting that the quality of the visual representation, rather than the lack of one, may result in partial awareness during the change blindness paradigm.
Influence of nearly resonant light on the scattering length in low-temperature atomic gases
Creators: name: Fedichev, P. O.
name: Kagan, Yu.
name: Shlyapnikov, G. V.
name: Walraven, J. T. M.
Publisher: name: arXiv
Year: 1996
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We develop the idea of manipulating the scattering length $a$ in low-temperature atomic gases by using nearly resonant light. As found, if the incident light is close to resonance with one of the bound $p$ levels of electronically excited molecule, then virtual radiative transitions of a pair of interacting atoms to this level can significantly change the value and even reverse the sign of $a$. The decay of the gas due to photon recoil, resulting from the scattering of light by single atoms, and due to photoassociation can be minimized by selecting the frequency detuning and the Rabi frequency. Our calculations show the feasibility of optical manipulations of trapped Bose condensates through a light-induced change in the mean field interaction between atoms, which is illustrated for $^7$Li.
description: 12 pages, 1 Postscript figure
Numerical analysis of renormalon technique in quantum mechanics
Creators: name: Penin, A. A.
name: Pivovarov, A. A.
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We discuss the ways of extracting a low energy scale of an underlying theory using high energy scattering data. Within an exactly solvable model of quantum mechanics we analyze a technique based on introduction of nonperturbative power corrections accounting for asymptotically small terms and an alternative approach exploiting a modified running coupling constant of the model and nonperturbative continuation of evolution equations into an infrared region. Numerical estimates show that the latter is more efficient in approximating low-energy data of the model.
description: 14 pages, Latex, the text is corrected according to the Phys.Lett.B referee comments
The Plasmodium falciparum Rh5 invasion protein complex reveals an excess of rare variant mutations.
Creators: name: Ndwiga, Leonard
name: Osoti, Victor
name: Ochwedo, Kevin Omondi
name: Wamae, Kevin
name: Bejon, Philip
name: Rayner, Julian C
name: Githinji, George
name: Ochola-Oyier, Lynette Isabella
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Malaria
Vaccine
linkage disequilibrium
Single Nucleotide Polymorphisms
Rh5
P113
Ripr
Cyrpa

description: BackgroundThe invasion of the red blood cells by Plasmodium falciparum merozoites involves the interplay of several proteins that are also targets for vaccine development. The proteins PfRh5-PfRipr-PfCyRPA-Pfp113 assemble into a complex at the apical end of the merozoite and are together essential for erythrocyte invasion. They have also been shown to induce neutralizing antibodies and appear to be less polymorphic than other invasion-associated proteins, making them high priority blood-stage vaccine candidates. Using available whole genome sequencing data (WGS) and new capillary sequencing data (CS), this study describes the genetic polymorphism in the Rh5 complex in P. falciparum isolates obtained from Kilifi, Kenya.Methods162 samples collected in 2013 and 2014 were genotyped by capillary sequencing (CS) and re-analysed WGS from 68 culture-adapted P. falciparum samples obtained from a drug trial conducted from 2005 to 2007. The frequency of polymorphisms in the merozoite invasion proteins, PfRh5, PfRipr, PfCyRPA and PfP113 were examined and where possible polymorphisms co-occurring in the same isolates.ResultsFrom a total 70 variants, including 2 indels, 19 SNPs [27.1%] were identified by both CS and WGS, while an additional 15 [21.4%] and 36 [51.4%] SNPs were identified only by either CS or WGS, respectively. All the SNPs identified by CS were non-synonymous, whereas WGS identified 8 synonymous and 47 non-synonymous SNPs. CS identified indels in repeat regions in the p113 gene in codons 275 and 859 that were not identified in the WGS data. The minor allele frequencies of the SNPs ranged between 0.7 and 34.9% for WGS and 1.1-29.6% for CS. Collectively, 12 high frequency SNPs (> 5%) were identified: four in Rh5 codon 147, 148, 203 and 429, two in p113 at codons 7 and 267 and six in Ripr codons 190, 259, 524, 985, 1003 and 1039.ConclusionThis study reveals that the majority of the polymorphisms are rare variants and confirms a low level of genetic polymorphisms in all proteins within the Rh5 complex.
Additional file 1 of Associations between air pollutants and acute exacerbation of drug-resistant tuberculosis: evidence from a prospective cohort study
Creators: name: Zhao, Chan-Na
name: Xu, Zhiwei
name: Wang, Peng
name: Liu, Jie
name: Wang, Rong
name: Pan, Hai-Feng
name: Bao, Fangjin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1: Table S1 RR (95% CIs) for the association between first-time outpatient visits for acute exacerbations of DR-TB and air pollutants concentrations with each IQR increase based on single-pollutant models. Table S2 Single-lag RR (95% CIs) for the association between first-time outpatient visits for acute exacerbations of DR-TB and air pollutants concentrations with each IQR increase based on two-pollutants models. Table S3 Cumulative RR (95% CIs) for the association between first-time outpatient visits for acute exacerbations of DR-TB and air pollutants concentrations with each IQR increase based on two-pollutants models. Figure S1. RR (95% CIs) for the association between first-time outpatient visits for acute exacerbations of DR-TB and air pollutants concentrations with each IQR increase based on single-pollutant models stratified by gender. Figure S2. RR (95% CIs) for the association between first-time outpatient visits for acute exacerbations of DR-TB and air pollutants concentrations with each IQR increase based on single-pollutant models stratified by age. Figure S3. RR (95% CIs) for the association between first-time outpatient visits for acute exacerbations of DR-TB and air pollutants concentrations with each IQR increase based on single-pollutant models stratified by occupation. Figure S4. RR (95% CIs) for the association between first-time outpatient visits for DR-TB and air pollutants concentrations with each IQR increase based on single-pollutant models stratified by high-risk subgroup. Figure S5. RR (95% CIs) for the association between first-time outpatient visits for DR-TB and air pollutants concentrations with each IQR increase based on single-pollutant models stratified by history of treatment. Figure S6. RR (95% CIs) for the association between first-time outpatient visits for DR-TB and air pollutants concentrations with each IQR increase based on single-pollutant models stratified by season
title: ESLO1: discussion en clôture de la séquence d'entretien 255_B
Creators: name: Laboratoire Ligérien De Linguistique
name: Baude, Olivier
name: Dugua, Céline
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015
Subjects: subject: Français
subject: fra
subject: text_and_corpus_linguistics

description: Extrait du corpus d'Orléans, réalisé dans le cadre de l'Enquête SocioLinguistique à Orléans à la fin des années 1960.
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
The exact minimum number of triangles in graphs of given order and size
Creators: name: Liu, Hong
name: Pikhurko, Oleg
name: Staden, Katherine
Publisher: name: arXiv
Year: 2017
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C35

description: What is the minimum number of triangles in a graph of given order and size? Motivated by earlier results of Mantel and Turán, Rademacher solved the first non-trivial case of this problem in 1941. The problem was revived by Erdős in 1955; it is now known as the Erdős-Rademacher problem. After attracting much attention, it was solved asymptotically in a major breakthrough by Razborov in 2008. In this paper, we provide an exact solution for all large graphs whose edge density is bounded away from~$1$, which in this range confirms a conjecture of Lovász and Simonovits from 1975. Furthermore, we give a description of the extremal graphs.
description: Published in Forum of Mathematics, Pi, Volume 8, e8 (2020)