cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
From Management to Adaptation: Designing an Organizational Learning Process for Strategic Renewal of Environmental Management at The City of Calgary
Creators: name: Bres, Audrey Faye
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Engineering--Environmental
subject: Adaptation
subject: Complexity
subject: Organizational learning
subject: Complex systems
subject: environmental management
subject: Sustainability

description: Complexity in human systems is both a phenomenon to be studied in research and a process to be applied in practice. In this study, theoretical characteristics of Complex Adaptive Systems (Holland, 2012) are applied to explore the self-organizing, or learning, capacity of a large human Organization, The City of Calgary. The Design-based Research methodology for testing an organizational learning intervention evolved as initial assumptions were challenged and an understanding of the unique character of The City as a Complex Adaptive System emerged. Through a 16-month interventionist field study involving three different research scenarios, the researcher and participants worked together to ‘solve problems’ using the existing and emerging organizational processes and structures at The City. A design process was developed and tested for designing organizational structures for adaptation, a form of organizing complementary to existing systems-based environmental management. Systems-based management at The City demonstrated capacity to efficiently control environmental impacts associated with the actions of operationally closed elements (Business Units) of the system, and to mitigate in non-standard conditions. An understanding of complexity characteristics of The City was used to generate a new strategic environmental adaptation framework to coordinate environmental action across operationally closed parts, in alignment with the current strategic direction of The City. Analysis of complexity characteristics of the system informed the design, including nesting of organizational structures, signal/boundaries, dynamic interactions, and a fractal interface between The City and its natural environment. The approval of the design for implementation at The City was an indicator of its validity in the full context of the Organization. An ‘executive function’ defines processes and organizational structures to ensure consistency and alignment between the parts of an Organization and to facilitate coordination of action towards commonly defined strategic goals. A theoretical/philosophical model is presented for practitioners, leaders, and researchers seeking to enhance organizational management through the application of Complexity Theory. This study is a practical example of a dynamic research process capable of having an impact on both theory development and practice, and aims to make human Organizations more adaptive to change as they work to establish non-harmful interactions with the environment.
Role of PKMz in morphological and synaptic development of optic tectal neurons in Xenopus laevis tadpoles in vivo
Creators: name: Liu, Xuefeng
Publisher: name: University of British Columbia
Year: 2010

description: PKMz (Protein Kinase M zeta) is a recently identified isoform of Protein Kinase C. It is persistently active upon synthesis because its sequence resembles the catalytic domain of PKC zeta but lacks the auto-inhibitory regulatory domain. Previous studies found that PKMz is critical for LTP maintenance, as well as learning and memory in the adult rat brain. However, it is not known whether and how it functions in developing neural systems. I have identified endogenous PKMz in Xenopus laevis tadpoles brain and found that its expression pattern is temporally and spatially correlated with synaptogenesis and dendritogenesis within tadpole retino-tectal system. By in vivo rapid time-lapse imaging and three-dimensional analysis of dynamic dendritic growth, I find that exogenous expression of PKMz within single neurons stabilizes dendritic filopodia by increasing dendritic filopodial lifetimes and decreasing filopodial additions, eliminations, and motility, whereas long-term in vivo imaging demonstrates restricted expansion of the dendritic arbor. Alternatively, blocking endogenous PKMz activity in individual growing tectal neurons with ZIP (zeta-inhibitory peptide) destabilizes dendritic filopodia and over long periods promotes excessive arbor expansion. Consistent with its established roles in regulating adult glutamatergic synaptic transmission, I also examined role of PKMz in regulating developing synapses, using both immunohistochemistry and in vivo patch clamp recording. Specifically, I find that knocking down endogenous PKMz using a morpholino impairs both transmission and maturation of glutamatergic synapses, and consistently induces promoted dendritic expansion as seen in ZIP treated neurons. The model that PKMz regulates dendritogenesis by regulating glutamatergic synaptic transmission was further investigated using a novel seizure model based on Xenopus tadpoles. I find that PTZ induced seizure activity increases normalized expression level of brain PKMz, which is required for over-stabilization of dendritic filopodia dynamics induced by seizure activity. Based on these findings, together with previous results from other related studies, I have constructed a discreet and stochastic computational model to simulate synaptotropic dendritic growth mechanism. I show that as formation of nascent synapses promotes dendritic expansion into region of synaptic partners by promoting maintenance of dendritic filopodia, synapse maturation drives further dendritic refinement and stabilization of appropriate dendritic structure.
Cultural factors
Creators: name: Karimi, Farid
Publisher: name: Zenodo
Year: 2023
Subjects: Social and political issues

description: Common cultural denominators affect all stakeholders Social and political issues listed: Political development
 Social acceptance
 Communication and the 'information deficit'
 Risk and benefit perceptions
 Cultural factors
 Social acceptability
 Trust in stakeholders
 NIMBY or not
 Public awareness of CCUS
Implementació d'un programa multidisciplinari de prevenció primària, secundària i terciària de Trastorn de Conducta Alimentària en pacients amb Diabetis Mellitus Tipus I en un hospital de tercer nivell
Creators: name: Etxandi, Mikel
name: Sanagustín, David
name: Loran, Maria Eulalia
name: Soldevila, Berta
name: López, Maria Teresa
name: De Pablo, Joan
name: Iglesias, Maria
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2022

description: Psicosomàtica y Psiquiatría, Núm. 23 (2022): octubre-noviembre-diciembre
NIMBY or not
Creators: name: Karimi, Farid
Publisher: name: Zenodo
Year: 2023
Subjects: Social and political issues

description: Is ‘Not In My Backyard’ a useful explanation for public responses to CCUS? Social and political issues listed: Political development
 Social acceptance
 Communication and the 'information deficit'
 Risk and benefit perceptions
 Cultural factors
 Social acceptability
 Trust in stakeholders
 NIMBY or not
 Public awareness of CCUS
БОРЬБА С КОРРУПЦИЕЙ В БРАЗИЛИИ: ОПЫТ И ПРОБЛЕМЫ
Creators: name: БРАЖНИКОВ ДМИТРИЙ АНАТОЛЬЕВИЧ
name: КЛИМЕНКО АЛЕКСЕЙ ИВАНОВИЧ
name: КОБЕЦ ПЕТР НИКОЛАЕВИЧ
Publisher: name: Вестник Московского университета МВД России
Year: 2020
Subjects: КОРРУПЦИЯ
КОРРУПЦИЯ В ГОСУДАРСТВЕННОМ АППАРАТЕ
ПРОТИВОДЕЙСТВИЕ КОРРУПЦИИ
ГРАЖДАНСКОЕ ОБЩЕСТВО
НАЦИОНАЛЬНЫЙ КОНГРЕСС БРАЗИЛИИ
ФЕДЕРАЛЬНОЕ ПРАВИТЕЛЬСТВО БРАЗИЛИИ
ФЕДЕРАЛЬНАЯ ПРОКУРАТУРА БРАЗИЛИИ
ФЕДЕРАЛЬНАЯ ПОЛИЦИЯ БРАЗИЛИИ
CORRUPTION
CORRUPTION IN THE STATE APPARATUS
CIVIL SOCIETY
ANTI-CORRUPTION
BRAZILIAN NATIONAL CONGRESS
BRAZILIAN FEDERAL GOVERNMENT
BRAZILIAN FEDERAL PROSECUTOR'S OFFICE
BRAZILIAN FEDERAL POLICE

description: Профессиональному сообществу предлагается анализ противодействия коррупционной преступности в Бразилии для того, чтобы, сосредоточившись на размышлениях и выводах в отношении этого феномена, в последствии выработать меры по противодействию коррупции. Актуальность рассматриваемой проблематики состоит в том, что в современных условиях в Бразилии прошла череда коррупционных скандалов. В этой связи целью исследования явился анализ проблематики бразильских коррупционных проявлений. В качестве методической основы при проведении исследования использовалась совокупность общенаучных и частнонаучных методов, в том числе исторический. В процессе исследования авторским коллективом была отмечена одна из важных тенденций, а именно рост коррупционной преступности в государственном аппарате латиноамериканских стран. В том числе сделан акцент относительно того, что коррупционные скандалы с участием представителей законодательной и исполнительной власти неизменно приводят к одному из важнейших для самоощущения общества явлению - его разочарованию в исполнительной власти, ее идеях и реформах. Авторским коллективом также делается вывод о том, что актуальность рассматриваемой проблемы состоит в том, что задачи предупреждения политической коррупции в государственном аппарате Бразилии связаны с решением огромного пласта проблем и вопросов, требующих их изучения и анализа. Новизна проведенного исследования выражается в том, что авторы обозначили основные направления противодействия коррупции в Бразилии. Проведенное авторским коллективом исследование опыта Бразилии в сфере противодействия коррупции может послужить методической основой по подготовке различных документов в сфере противодействия коррупции в России. Данное исследование будет представлять интерес для специалистов, озабоченных проблемами борьбы с коррупцией в органах государственной власти.
La inmutable Hipocondría: de los nuevos modelos a los resultados de un protocolo de evaluación y su implicación en el pronóstico y en las propuestas terapéuticas
Creators: name: Machado, Eduarda
name: Molinero, Laia
name: Pardo, Judit
name: Martín, Maria
name: Palazón, Alba
name: Farré, JM
name: Mallorquí, Núria
name: Lasheras, Gracia
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2022

description: Psicosomàtica y Psiquiatría, Núm. 23 (2022): octubre-noviembre-diciembre
Cyclodextrin Chemistry: Synthesis of Amphiphilic Fluorescent Glycodendrimers and Development of Acid-mediated O-desilylation Methodology
Creators: name: Chen, Tong
Publisher: name: Graduate Studies
Year: 2015
Subjects: subject: Chemistry--Organic
subject: Cyclodextrin Chemistry
subject: Synthesis
subject: Methodology

description: Cyclodextrins (CDs) constitute a group of D-glucose-based host molecules with a hydrophobic cavity that can be used to form inclusion complexes with organic compounds. The Ling group has developed a group of amphiphilic glycodendrimers which have been shown to self-assemble into nanoparticles in water, and such systems have been confirmed to deliver anticancer medicines into cancer cells. To further study the cellular uptake mechanism, the present thesis work concerns the design and synthesis of a class of amphiphilic CD-based glycodendrimers containing a fluorophore. NBD was chosen as the fluorophore because it is small and non-ionic. The DIBAL-H reagent allowed a two-fold differentiation of primary hydroxyl groups of the CD molecules, which facilitated the sequential addition of NBD and of sugar moieties. A novel acid-catalyzed O-desilylation methodology has also been developed from this thesis work using the easily accessible per-3,6-O-silylated CD substrates in a mixture of methanol-chloroform.
Personality and Nomophobia: The Role of Dysfunctional Obsessive Beliefs
Creators: name: García Masip, Victoria
name: Sora, Bea
name: Boada, Joan
name: Serrano, María José
name: Lampert, Bettina
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2022

description: Psicosomàtica y Psiquiatría, Núm. 23 (2022): octubre-noviembre-diciembre
Dynamics and efficiency of a self-propelled, diffusiophoretic swimmer
Creators: name: Sabass, Benedikt
name: Seifert, Udo
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Biological Physics (physics.bio-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Active diffusiophoresis - swimming through interaction with a self-generated, neutral, solute gradient - is a paradigm for autonomous motion at the micrometer scale. We study this propulsion mechanism within a linear response theory. Firstly, we consider several aspects relating to the dynamics of the swimming particle. We extend established analytical formulae to describe small swimmers, which interact with their environment on a finite lengthscale. Solute convection is also taken into account. Modeling of the chemical reaction reveals a coupling between the angular distribution of reactivity on the swimmer and the concentration field. This effect, which we term "reaction induced concentration distortion", strongly influences the particle speed. Building on these insights, we employ irreversible, linear thermodynamics to formulate an energy balance. This approach highlights the importance of solute convection for a consistent treatment of the energetics. The efficiency of swimming is calculated numerically and approximated analytically. Finally, we define an efficiency of transport for swimmers which are moving in random directions. It is shown that this efficiency scales as the inverse of the macroscopic distance over which transport is to occur.
description: 16 pages, 11 figures
Trust in stakeholders
Creators: name: Karimi, Farid
Publisher: name: Zenodo
Year: 2023
Subjects: Social and political issues

description: Public trust in various stakeholders impacts the acceptance Social and political issues listed: Political development
 Social acceptance
 Communication and the 'information deficit'
 Risk and benefit perceptions
 Cultural factors
 Social acceptability
 Trust in stakeholders
 NIMBY or not
 Public awareness of CCUS
МОЛОДЕЖНАЯ ПРЕСТУПНОСТЬ В РОССИИ: ПОНЯТИЕ И ОСОБЕННОСТИ
Creators: name: КОШЕЛЕВА ЕЛЕНА ВИКТОРОВНА
name: ЛЕЛЕКОВ ВИКТОР АНДРЕЕВИЧ
Publisher: name: Вестник Московского университета МВД России
Year: 2020
Subjects: МОЛОДЕЖНАЯ ПРЕСТУПНОСТЬ
СОСТОЯНИЕ
ОСОБЕННОСТИ
СТРУКТУРА МОЛОДЕЖНОЙ ПРЕСТУПНОСТИ
YOUTH CRIME
STATE
FEATURES
STRUCTURE OF YOUTH CRIME

description: Раскрываются понятие и особенности молодежной преступности в России, ее количественные и качественные показатели.
Seguimiento al alta de hospitalización por intento de suicidio
Creators: name: Yárnoz Goñi, Nora
name: Goñi Sarriés, Adriana
name: López Goñi, José J.
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2022

description: Psicosomàtica y Psiquiatría, Núm. 23 (2022): octubre-noviembre-diciembre
"El médico del rey"
Creators: name: Ugedo Alzaga, Asier
name: Pintado Ramirez, Itziar
name: San Román Uría, Alberto
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2022

description: Psicosomàtica y Psiquiatría, Núm. 23 (2022): octubre-noviembre-diciembre
The Hydrological Impact of a Mountain Pine Beetle Infestation on the Upper Elbow River Watershed
Creators: name: Shawn, Tse
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: Engineering--Civil
subject: Engineering--Environmental
subject: mountain pine beetle
subject: elbow river

description: To determine the hydrological impact of a large-scale mountain pine beetle (abbreviated as MPB) infestation on the Upper Elbow River watershed, a hydrological model was created and calibrated using a dataset from Alberta Environment over the years 2003 - 2005. The root mean squared error of the flow was approximately 10.6 m3/s. The greatest error occurred in Jun 2005 where a much higher amount of precipitation than the previous two years was recorded. An MPB model was used to simulate an epidemic infestation. Various different scenarios were attempted, but the increase in the water yield of the Elbow River watershed could not be confirmed.
Interactions between Biofilm Growth and Fluid Flow in Porous Media
Creators: name: Bozorg, Ali
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: Engineering
subject: Hydrology
subject: Engineering--Chemical
subject: Biofilm
subject: Porous Media
subject: Modelling
subject: Bioluminescence
subject: Hydrogeology
subject: Spatiotemporal Development
subject: Relative Permeability
subject: Imaging

description: Many engineered and natural systems are influenced by biofilms, which are surface attached communities of microorganisms embedded in a matrix composed of microbially produced extracellular polymeric substances. In porous media, biofilms can progressively accumulate within pore spaces, making it increasingly difficult for fluids to flow through the pore network. Therefore, biofilms are often considered to be detrimental in processes relying on fluid flow in porous media. Engineering biofilm development in porous structures, however, can maximize the beneficial aspects of biofilms while minimizing their detrimental effects. Due to an inadequate understanding of interactions between flow properties and biofilm development, field scale applications of biofilm based processes are still unpredictable. This study was divided to two main parts. The first part focused on a theoretical investigation of biofilm growth in porous media. By treating biofilm as an evolving viscous fluid that shares void spaces with a separate aqueous phase in porous media, a novel macroscopic approach was developed to simulate biofilm growth in porous media. Modelling results revealed that relative permeability functions can be used to link flow of water to biofilm saturation. However, this modelling approach was complex, and certain model parameters needed to be experimentally determined. Therefore, in the second part of the study, by using a bioluminescent bacterium, a noninvasive imaging method was developed to visualize biofilm evolution within porous media. Detected bioluminescence intensities were used to nondestructively quantify biofilm and porous media characteristics. The imaging technique was also used to study bacterial transport in porous media with different hydraulic properties. Results indicated that biofilm formation can significantly improve bacterial sticking efficiency in porous media by modifying hydrophobicity of solid surfaces. Finally, the developed imaging technique was used to monitor biofilm development under a constant pressure gradient in a two-dimensional flow field. Results revealed that in porous media with small pore sizes and low permeabilities, biofilm grows predominantly in upstream regions toward the nutrient source and against the fluid flow, whereas in porous media with coarse pore sizes and elevated permeabilities, biofilm primarily disperses in the downstream direction, in the same direction as the fluid flow, but away from the nutrient source. Observed differences in growth patterns could be explained by considering the pore size distribution in a given medium.
Pharmacoepidemiologic studies of statins in rheumatoid arthritis
Creators: name: De Vera, Mary Abigail
Publisher: name: University of British Columbia
Year: 2010

description: Introduction: This thesis comprises four studies aimed at improving current understanding of statin use in rheumatoid arthritis (RA), a patient population with established CVD risk. There is need for a better understanding of the cardioprotective role of statins in RA through dual lipid-lowering and anti-inflammatory effects. Since deriving therapeutic effect from medication depends not only on physicians prescribing treatment but also on patients’ compliance with therapy, there is also need for better understanding of the impact of statin compliance on relevant outcomes in RA. Objectives: 1) To evaluate whether statin use has a cardioprotective effect among individuals with RA; 2) To synthesize current evidence on adverse outcomes associated with discontinuation of statin therapy; 3) To evaluate the impact of statin discontinuation on risk of acute myocardial infarction (AMI) among RA patients prescribed with statins; and 4) To evaluate the impact of statin discontinuation on risk of mortality among RA patients prescribed with statins. Methods: To address Objectives 1, 3, and 4, I conducted three longitudinal studies of a population-based RA cohort in BC. To address Objective 2, I conducted a systematic review. Results: 1) Statin use is associated with a 31% lower risk of AMI in RA patients; 2) There is a consistent finding of increased risk of adverse outcomes associated with statin discontinuation in different patient populations; highlighting the importance of compliance in patients who are prescribed statins for primary or secondary prevention; 3) Discontinuation of statin therapy is associated with a 67% increased risk of AMI among patients with RA; 4) Discontinuation of statin therapy is associated with 60% and 79% increased risk of cardiovascular disease mortality and all-cause mortality, respectively, in patients with RA. Conclusion: Altogether as a collective work, this thesis provides supporting evidence for a substantial role of statins in management of CVD, a key comorbidity in RA, and additionally highlights the importance of patient compliance with statin therapy in achieving therapeutic goals of treatment.
КРИМИНОЛОГИЧЕСКАЯ ХАРАКТЕРИСТИКА НЕКОТОРЫХ ПРИЗНАКОВ ЛИЧНОСТИ «ХАКЕРА»: НА ОСНОВЕ АНАЛИЗА МАТЕРИАЛОВ СУДЕБНОЙ ПРАКТИКИ
Creators: name: ХАЛИУЛЛИН АДЕЛЬ ИЛЬФАТОВИЧ
Publisher: name: Вестник Московского университета МВД России
Year: 2020
Subjects: ПРЕСТУПЛЕНИЯ В СФЕРЕ КОМПЬЮТЕРНОЙ ИНФОРМАЦИИ
КИБЕРПРЕСТУПЛЕНИЯ
ЛИЧНОСТЬ ПРЕСТУПНИКА
ХАКЕР
СКРИПТОВЫЙ ПРЕСТУПНИК
СЕТЬ ИНТЕРНЕТ
СУБКУЛЬТУРА ХАКЕРОВ
CRIMES IN THE FIELD OF COMPUTER INFORMATION SYSTEMS
CYBER CRIMES
PERSONALITY OF A CRIMINAL
HACKER
SCRIPT CRIMINAL
NETWORK INTERNET
SUBCULTURE OF HACKERS

description: Проанализированы некоторые особенности личности «хакера» как профессионального участника сферы применения информационных технологий. Рассмотрены специфические мотивы криминальной деятельности, производные от существующей субкультуры «хакеров». На основе анализа материалов судебной практики дана характеристика отдельным криминологически значимым признакам личности «хакера», приведены основные направления их криминальной деятельности.
Evaluation of Catalytic Steam Cracking Process for Total Acid Number Reduction of Heavy Oils
Creators: name: Moraes Righi, Thiago
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Engineering--Chemical
subject: Engineering--Petroleum
subject: Heavy oil processing
subject: Total acid number
subject: Catalytic Steam Cracking

description: This study aims to evaluate the performance of different catalysts and conditions in the activity and deactivation patterns of catalytic steam cracking for total acid number reduction in northern Alberta bitumen. Several heavy oil properties relevant for their commercialization were also investigated. The conditions tested varied from 360-390oC and 800-4,200kPa. The results showed a great activity towards total acid number reduction, further enhanced when using a hydrogenating function containing catalyst. A kinetic study was performed initially excluding the effects of deactivation. The study over extended hours of continuous operation revealed a progressive deactivation. In response to this behavior a guard reactor was implemented. This deactivation was modeled and a regeneration test was successfully performed. Poisoning by metal deposition was found to be negligible over time-on-stream thus deactivation was mainly due to coke deposition. A commercial reaction scheme was proposed and economically evaluated.
Existence and uniqueness of a positive solution to generalized nonlocal thermistor problems with fractional-order derivatives
Creators: name: Ammi, Moulay Rchid Sidi
name: Torres, Delfim F. M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 26A33, 35B09, 45M20

description: In this work we study a generalized nonlocal thermistor problem with fractional-order Riemann-Liouville derivative. Making use of fixed-point theory, we obtain existence and uniqueness of a positive solution.
description: Submitted 17-Jul-2011; revised 09-Oct-2011; accepted 21-Oct-2011; for publication in the journal 'Differential Equations & Applications' (http://dea.ele-math.com)
Flame Wrinkles From the Zhdanov-Trubnikov Equation
Creators: name: Joulin, Guy
name: Denet, Bruno
Publisher: name: arXiv
Year: 2012
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The Zhdanov-Trubnikov equation describing wrinkled premixed flames is studied, using pole-decompositions as starting points. Its one-parameter (-1< c <1) nonlinearity generalizes the Michelson-Sivashinsky equation (c=0) to a stronger Darrieus-Landau instability. The shapes of steady flame crests (or periodic cells) are deduced from Laguerre (or Jacobi) polynomials when c = -1, which numerical resolutions confirm. Large wrinkles are analysed via a pole density: adapting results of Dunkl relates their shapes to the generating function of Meixner-Pollaczek polynomials, which numerical results confirm for 10 (over-stabilization) such analytical solutions can yield accurate flame shapes for 0< c <0.6. Open problems are invoked.
The Impact of Study Methodology on Studying Genetic and Environmental Risk Factors for the Inflammatory Bowel Diseases
Creators: name: Kuenzig, Mary Ellen
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Epidemiology
subject: Inflammatory Bowel Disease
subject: Crohn's disease
subject: Ulcerative Colitis
subject: smoking
subject: NOD2
subject: Asthma
subject: gene-environment interactions

description: Inflammatory bowel disease (IBD), comprised of Crohn’s disease and ulcerative colitis, results from a complex interaction between genetic and environmental factors. NOD2 and cigarette smoking are two of the most commonly replicated genetic and environmental risk factors, respectively, for Crohn’s disease. Studies examining the interaction between NOD2 and smoking in patients with Crohn’s disease have reached heterogeneous conclusions. Study methodology may explain these differences. Chapters Three and Four evaluate NOD2-smoking interactions in Crohn’s disease with a focus on study methodology. Chapter Three is a systematic review and meta-analysis that found a negative interaction between NOD2 and smoking. However, this interaction is SNP-specific and influenced by the definition of smoking used (i.e., dichotomizing smoking status vs. separately analyzing current, former, and never smoking). Using a case-only study design (Chapter Four), the impact of age at diagnosis was explored as a potential mechanism for the negative interaction between NOD2 and smoking. Age at diagnosis exhibits opposing trends in the proportion of individuals that carry a NOD2 mutation and smoke, with NOD2 being significantly more common among young individuals while smoking is more common among those older at diagnosis. Combining individuals of all ages artificially results in a negative interaction between these two factors. Chapter Five assesses the association between smoking and the need for surgery in patients with Crohn’s disease or ulcerative colitis in a systematic review and meta-analysis only including studies that separately analyzed current, former, and never smokers. Included studies also incorporated disease duration in the analysis. In the final manuscript, a case-control study using administrative data from Alberta Health was used to examine the association between asthma and Crohn’s disease or ulcerative colitis. Age at diagnosis modified the association between ulcerative colitis and asthma and these two diseases were only associated for individuals under the age of 17 or over the age of 40. The association between asthma and Crohn’s disease was consistently observed across all ages. The conclusions of all four manuscripts emphasize that study methodology may influence study results; this includes how exposure (genetic or environmental) and how sub-phenotypes (i.e., early- or late-onset) of disease are analyzed.
Blood Volume Monitoring Guided Ultrafiltration Biofeedback on the Reduction of Intradialytic Hypotensive Episodes in Hemodialysis
Creators: name: Leung, Kelvin Cheuk-Wai
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Medicine and Surgery
subject: Hemodialysis
subject: randomized controlled trial
subject: Biofeedback
subject: Intradialytic Hypotension

description: The majority of patients with end stage renal disease rely on hemodialysis (HD) to maintain fluid balance. Unfortunately, rapid fluid removal [ultrafiltration (UF)] often results in symptomatic, intradialytic hypotension (IDH). Our objective was to perform a randomized controlled crossover trial to evaluate the effectiveness of a blood volume monitoring guided UF biofeedback in the reduction of symptomatic IDH. Over the study period, symptomatic patients first had their dialysis prescription and dry weight optimized over a four-week period before being randomized to an eight-week biofeedback intervention or standard control HD. There was a two-week washout period before patients crossed over for a second eight-week study period. There were no differences in the rate of symptomatic IDH, volume status (as measured by electrical bioimpedance), or biomarkers of cardiac stress between the two groups.
Suzaku investigation into the nature of the nearest ultraluminous X-ray source, M33 X-8
Creators: name: Isobe, Naoki
name: Kubota, Aya
name: Sato, Hiroshi
name: Mizuno, Tsunefumi
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The X-ray spectrum of the nearest ultraluminous X-ray source, M33 X-8, obtained by Suzaku during 2010 January 11 -- 13, was closely analyzed to examine its nature. It is, by far, the only data with the highest signal statistic in 0.4 -- 10 keV range. Despite being able to reproduce the X-ray spectrum, Comptonization of the disk photons failed to give a physically meaningful solution. A modified version of the multi-color disk model, in which the dependence of the disk temperature on the radius is described as r^(-p) with p being a free parameter, can also approximate the spectrum. From this model, the innermost disk temperature and bolometric luminosity were obtained as T_in = 2.00-0.05+0.06 keV and L_disk = 1.36 x 10^39 (cos i)^(-1) ergs/s, respectively, where i is the disk inclination. A small temperature gradient of p = 0.535-0.005+0.004, together with the high disk temperature, is regarded as the signatures of the slim accretion disk model, suggesting that M33 X-8 was accreting at high mass accretion rate. With a correction factor for the slim disk taken into account, the innermost disk radius, R_in =81.9-6.5+5.9 (cos i)^(-0.5) km, corresponds to the black hole mass of M \sim 10 M_sun (cos i)^(-0.5). Accordingly, the bolometric disk luminosity is estimated to be about 80 (cos i)^(-0.5)% of the Eddington limit. A numerically calculated slim disk spectrum was found to reach a similar result. Thus, the extremely super-Eddington luminosity is not required to explain the nature of M33 X-8. This conclusion is utilized to argue for the existence of intermediate mass black holes with M > 100 M_sun radiating at the sub/trans-Eddington luminosity, among ultraluminous X-ray sources with L_disk > 10^(40) ergs/s.
description: 10 pages, 4 figures, PASJ accepted
Predictors of COVID-19 health behavior: A scoping review of causal research
Creators: name: Ponizovskiy, Vladimir
name: Grelle, Sonja
name: Jule Oettinghaus
name: Hofmann, Wilhelm
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: Health Psychology
subject: Psychology
subject: FOS: Psychology

description: This document serves as the preregistration of the protocol for the scoping review "Predictors of COVID-19 health behavior: A scoping review of causal research"
Chronic Wasting Disease: Investigations on Prion Shedding and Risk of Transmission to Caribou
Creators: name: Cheng, Yo Ching
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Animal Pathology
subject: Genetics
subject: FOS: Biological sciences
subject: Biology--Molecular
subject: Veterinary Science
subject: Chronic Wasting Disease
subject: Prions
subject: Prion diseases
subject: diagnosis
subject: Caribou
subject: Elk
subject: Surveillance
subject: RT-QuIC

description: Chronic wasting disease (CWD) is a transmissible prion disease affecting cervids mainly in North America. The responsible agent for this disease is the protease-resistant and infectious prion protein isoform (PrPSc) which is converted from a normal host-encoded glycoprotein (PrPC). In this study, I employed a novel in vitro amplification assay; the real-time quaking-induced conversion assay (RT-QuIC) to detect CWD prions in feces. I demonstrated the use of optimized RT-QuIC to define the shedding pattern of CWD prions in feces during the course of CWD. Additionally, I analyzed the distribution of PrP polymorphism among caribou populations in Alberta. The results permit predictions on the probability of CWD transmission to caribou populations. My studies provide a new tool to improve CWD surveillance and transmission risk assessment, and may be useful for CWD management in the future.
Respect for private and family life under Article 8 ECHR in immigration cases: A human right to regularize illegal stay?
Creators: name: Thym, Daniel
Publisher: name: Humboldt-Universität zu Berlin
Year: 2008
Subjects: subject: 340 Recht

description: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
description: Applying the European Convention on Human Rights (ECHR) to immigration cases has always been a balancing exercise between the effective protection of human rights and the Contracting States' autonomy to regulate migration flows. In its recent case law, the European Court of Human Rights in Strasbourg (ECtHR) has considerably extended the protective scope of Article 8 ECHR by granting autonomous human rights protection to the long-term resident status independent of the existence of family bonds under the heading of ‘private life’. This has important repercussions for the status of legal and illegal immigrants across Europe, since the new case law widens the reach of human rights law to the legal conditions for leave to remain, effectively granting several applicants a human right to regularize their illegal stay. The contribution analyses the new case law and develops general criteria guiding the application of the ECHR to national immigration laws and the new EU harmonization measures adopted in recent years.
Risk and benefit perceptions
Creators: name: Karimi, Farid
Publisher: name: Zenodo
Year: 2023
Subjects: Social and political aspects

description: Status of knowledge on public perceptions of risks and benefits of CCUS Social and political issues listed: Political development
 Social acceptance
 Communication and the 'information deficit'
 Risk and benefit perceptions
 Cultural factors
 Social acceptability
 Trust in stakeholders
 NIMBY or not
 Public awareness of CCUS
Neuroimaging and Robotic Assessment of Proprioceptive Impairments Post-Stroke
Creators: name: Kenzie, Jeffrey
Publisher: name: Graduate Studies
Year: 2017
Subjects: Anatomy
Neuroscience
Rehabilitation and Therapy
Robotics

description: Background: Proprioception is the sense of position (position sense) and movement (kinesthesia) of our limbs and body. It is important for performing coordinated volitional movements, and is often affected after stroke, leading to worse functional recovery. Proprioception is difficult to reliably assess with current clinical measures. This thesis performed proprioceptive assessments in subjects with recent stroke using a robotic exoskeleton called a KINARM. Chapter Two identified specific lesion locations in a sample of subjects with recent stroke (n=142) that were associated with impairments in different aspects of kinesthesia (e.g. speed, direction, and amplitude of movement perception). Lesions to frontal, parietal and temporal cortices, and the insula were associated with impairments in kinesthesia. Chapter Three incorporated multiple measures from position sense and kinesthesia robotic tasks into a single composite score of proprioception. Proprioceptive impairments were common (over 60%, n=285) after stroke, and were correlated with clinical measures of functional independence. This composite score will have utility in monitoring proprioceptive impairments in future rehabilitation clinical trials. Next, Chapters Four and Five utilized functional MRI (fMRI) to identify disruptions in brain activity related to proprioceptive impairments. Chapter Four used a position-matching device and task during fMRI to identify brain areas associated with impaired proprioception. The ipsilesional supramarginal and superior temporal gyri as well as bilateral supplementary motor and ipsilesional premotor cortices were associated with impaired proprioception in subjects with recent stroke (n=16). Chapter Five measured resting-state functional connectivity in subjects with stroke (n=17) using fMRI. Changes in functional connectivity were computed in relation to impaired proprioception (measured using the KINARM). Impaired proprioception was associated with decreased functional connectivity between 1) contralesional opercular area 1 (seed) and ipsilesional temporal and parietal areas, and 2) supplementary motor/premotor areas (seed) and ipsilesional SI and supramarginal gyrus. Conclusions: We have developed an objective and reproducible robotic-based outcome measure of upper limb proprioception. Proprioception in the human brain appears to involve primary sensorimotor structures (e.g. SI, MI) and higher-level association areas such as superior and inferior parietal cortices, supplementary motor and premotor cortices.
Answering Non-Monotonic Queries in Relational Data Exchange
Creators: name: Hernich, Andre
Publisher: name: arXiv
Year: 2011
Subjects: subject: Databases (cs.DB)
subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences
subject: cs.LO

description: Relational data exchange is the problem of translating relational data from a source schema into a target schema, according to a specification of the relationship between the source data and the target data. One of the basic issues is how to answer queries that are posed against target data. While consensus has been reached on the definitive semantics for monotonic queries, this issue turned out to be considerably more difficult for non-monotonic queries. Several semantics for non-monotonic queries have been proposed in the past few years. This article proposes a new semantics for non-monotonic queries, called the GCWA*-semantics. It is inspired by semantics from the area of deductive databases. We show that the GCWA*-semantics coincides with the standard open world semantics on monotonic queries, and we further explore the (data) complexity of evaluating non-monotonic queries under the GCWA*-semantics. In particular, we introduce a class of schema mappings for which universal queries can be evaluated under the GCWA*-semantics in polynomial time (data complexity) on the core of the universal solutions.
description: 55 pages, 3 figures
Awareness of Morally Motivated Reasoning - Study 1
Creators: name: Jettinghoff, William
name: Shariff, Azim
name: Laurin, Kristin
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social Psychology
subject: Personality and Social Contexts
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: This registration includes a PDF of the preregistration as well as the survey materials for a study on morally motivated reasoning.
Characterization of Human Airway Epithelial to Mesenchymal Transition upon Rhinovirus Infection
Creators: name: Minor, Danielle Marie
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Biophysics--Medical
subject: Epithelial cells
subject: Human rhinovirus
subject: epithelial to mesenchymal transition

description: Human rhinovirus (HRV)-induced wheezing illnesses in early life are a major risk factor for subsequent asthma development, and may contribute to induction and progression of airway remodeling (AR) seen in the airways of asthmatic subjects. Thickening of the lamina reticularis is a component of AR that is due to increased deposition of matrix proteins by mesenchymal cells that are increased in asthmatic airways, although the origin(s) of these cells are unclear. We have shown that two different strains of HRV, alone and in the presence of transforming growth factor-β1, caused phenotypic changes in epithelial cells consistent with the process of epithelial to mesenchymal transition. Viral replication was not essential for phenotypic changes, which appear to be mediated, in part, via activation of mitogen activated protein kinase pathways, and via induction of the transcription factor, SLUG. These data support a role for HRV in the development and progression of AR.
Theory overview of charm physics
Creators: name: Fajfer, S.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Recent developments in charm physics within the standard model and beyond are reviewed. The precision study of leptonic charm meson decays accompanied with the constraints coming from K, B and tau physics enables to determine constraints on models of new physics. The standard model contributions in the D0 - D0bar system are still under investigation including operators of higher dimensions. New physics models such as the Littlest Higgs model or warped extra-dimensional models might modify the amount of CP violation, although CP violating asymmetries are still predicted to be at most of the order 1%. The forward-backward asymmetry in the top anti-top pair production at the Tevatron is opening a new window in the study of new physics in the charm sector. A few of the models considered to explain the observed asymmetry might modify flavor changing neutral current mediated charm processes. New physics searches in rare charm decays are discussed. It is pointed out that in most models new physics effects in rare charm decays are insignificant.
Modelo de salud mental comunitaria para la atención de la psicosis emergente en una unidad especializada de detección temprana: seguimiento a un año
Creators: name: Marín, Lorena
name: Guardia, Armand
name: Mari, Nuria
name: Bosch, Elena
name: Domínguez, Noelia
name: Sánchez, Gemma
name: Pérez, Anabel
name: Natividad, Mentxu
name: Llos, Dolors
name: González-Rodríguez, Alexandre
name: Monreal, José Antonio
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2022

description: Psicosomàtica y Psiquiatría, Núm. 23 (2022): octubre-noviembre-diciembre
The Role of Calcium in the Mechanism of Muscle Fatigue in Intact, Single Muscle Fibres of Mice at Physiological Temperature
Creators: name: Glass, Lisa
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Animal Physiology
subject: force
subject: [Ca2+]m
subject: Ca2+ sensitivity
subject: submaximal repeated contractions
subject: muscle fatigue

description: The purpose of this study was to investigate the role of Ca2+ in the mechanism of fatigue during repeated submaximal contractions. Intact, mouse single muscle fibres were fatigued at 32C with intermittent submaximal stimulation until 40% of initial force. A force-[Ca2+]m relationship was determined prior to fatigue and during a 35 min recovery period. During fatigue, [Ca2+]m at 50% of maximum force (Ca50) increased significantly, demonstrating a decrease in Ca2+ sensitivity. Early in the period of intermittent contractions, Ca50 increased with an increase in [Ca2+]m followed by potentiation which was evident with a decrease in Ca50. However, Ca2+ sensitivity was never better than in the control condition. Throughout fatigue, both [Ca2+]m and sensitivity played a role in decreasing force. By 5 min of recovery, Ca50 had recovered and was not significantly different from Ca50 before fatigue. These results show that both [Ca2+]m and sensitivity play a role in fatigue.
ОСОБЕННОСТИ КВАЛИФИКАЦИИ НЕПРАВОМЕРНОГО ЗАВЛАДЕНИЯ АВТОМОБИЛЕМ СЕРВИСА «КАРШЕРИНГА» БЕЗ ЦЕЛИ ХИЩЕНИЯ
Creators: name: ХАЛИУЛЛИНА ЛЯЛЯ ГАРАФИЕВНА
Publisher: name: Вестник Московского университета МВД России
Year: 2020
Subjects: УГОН
НЕПРАВОМЕРНОЕ ЗАВЛАДЕНИЕ АВТОМОБИЛЕМ
ХИЩЕНИЕ
КРАТКОСРОЧНАЯ АРЕНДА АВТОМОБИЛЯ
КАРШЕРИНГ
БЕСПИЛОТНЫЙ ТРАНСПОРТ
КВАЛИФИКАЦИЯ ПРЕСТУПЛЕНИЙ
ИНФОРМАТИЗАЦИЯ
THEFT
ILLEGAL CAR OWNERSHIP
SHORT-TERM CAR RENTAL
CARSHARING
DRIVERLESS TRANSPORT
QUALIFICATION OF CRIMES
INFORMATIZATION

description: Рассмотрено влияние информатизации общественных отношений на изменение подходов к квалификации деяний. Оказание услуг сервисами «каршеринга» осуществляется с широким использованием информационных технологий, дистанционной идентификации пользователя и бесконтактной оплаты услуг аренды автомобиля. Традиционные подходы к квалификации неправомерного завладения автомобилем «каршеринга» требуют пересмотра с учетом особенностей новых информационных технологий.
Synthesis and Reactivity of New PCP Pincer Rhodium(I) and (III) complexes
Creators: name: Logan, Jessamyn
Publisher: name: Graduate Studies
Year: 2015
Subjects: subject: Chemistry--Inorganic
subject: Rhodium
subject: Inorganic
subject: Pincer

description: The development of well-understood, easily tuneable ligands has become important in the discovery and synthesis of new catalysts and catalytic systems. PCP pincer ligands, due to their tunability and stability, have been used in a variety of catalytic systems since their discovery over 30 years ago. In this work, two bis-(2-(dialkylphosphino)phenyl)methane ligands were complexed with rhodium through single and double C-H activations to give PC(sp3)P and PC(carbene)P complexes. The mechanism of ligand attachment through C-H activation was explored through the isolation and characterization of intermediates. The structure of the subsequently formed complexes, as well as their reactivity with small molecules such as H2, CO, O and N2O was also explored.
Manejo terapéutico del trastorno delirante en una Unidad de Salud Mental de Subagudos: serie de casos y una revisión de trabajos recientes.
Creators: name: Alberto Marcus, María
name: González-Rodríguez, Alexandre
name: Natividad, Mentxu
name: Maria Argemí, Maria
name: Alvarez, Aida
name: Guàrdia, Armand
name: Ros, Laura
name: Llos, Dolors
name: Monreal, José A.
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2022

description: Psicosomàtica y Psiquiatría, Núm. 23 (2022): octubre-noviembre-diciembre
Social acceptability
Creators: name: Karimi, Farid
Publisher: name: Zenodo
Year: 2023
Subjects: Social and political issues

description: The emergence of social acceptance Social and political issues listed: Political development
 Social acceptance
 Communication and the 'information deficit'
 Risk and benefit perceptions
 Cultural factors
 Social acceptability
 Trust in stakeholders
 NIMBY or not
 Public awareness of CCUS