cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Expression und Regulation antimikrobieller Peptide an der Augenoberfläche und im Tränenapparat des Menschen
Creators: name: Garreis, Fabian
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2012
Subjects: subject: Genexpression
subject: Peptide
subject: Antimikrobieller Wirkstoff
subject: Online-Publikation
subject: Hochschulschrift
subject: 615
subject: 610
subject: 615;572

description: Die Epithelien der Augenoberfläche schützen sich vor einer mikrobiellen Invasion durch die Produktion eines ganzen Arsenals konstitutiv gebildeter und induzierbarer antimikrobieller Peptide (AMPs). In der vorliegenden Arbeit wurde die Expression und Regulation der humanen β-Defensine (hBDs) sowie der an der Augenoberfläche und im Tränenapparat unbekannten antimikrobiell wirksamen Proteine Psoriasin, Filaggrin-2 und Hornerin untersucht. Die vorliegenden Ergebnisse zeigen, dass hBD-1, -2, -3 und -4 konstitutiv in der Konjunktiva, aber nur teilweise in der Kornea exprimiert werden. Die höchste Psoriasin-Konzentration (169 ng/mg) konnte in der Tränenflüssigkeit von gesunden Probanden nachgewiesen werden, wohingegen die Konzentration der hBDs im Picogramm Bereich liegen. Die Expression der untersuchten AMP wird durch proinflammatorische Zytokine, Wachstumsfaktoren und bakteriellen Bestandteilen signifikant induziert. Die vorliegenden Ergebnisse erweitern das bekannte Repertoire antimikrobieller Substanzen sowie das Verständnis über die Expression und Regulation der untersuchten Proteine an der Augenoberfläche.
description: Ocular surface epithelia protect themselves from microbial invasion by producing a whole range of constitutively expressed and inducible antimicrobial peptides (AMPs). In the present work the expression and regulation of human β-defensins (hBDs), Psoriasin as well as Hornerin were analyzed at the ocular surface and the lacrimal apparatus. The present results demonstrated that hBD-1, -2, -3 and -4 are constitutively expressed in the conjunctiva, but only partly in the cornea. Psoriasin and Hornerin are constitutively expressed in body donor tissue of the ocular surface and the lacrimal apparatus. The highest Psoriasin concentration (169 ng/mg) could be detected in the tear fluid of healthy donors whereas the concentrations of the hBD peptides are in pictogram range. Stimulation experiments with proinflammatory cytokines, growth factors and bacterial components leads to a significant induction of analyzed AMPs. The present results expand the known repertoire of antimicrobial molecules as well as the knowledge of the expression and regulation of the analyzed proteins at the ocular surface and in the lacrimal apparatus.
Untersuchungen zu genetischen Varianten von atherosklerotischen Risikogenen in einer Population gesunder Blutspender der Region Halle-Merseburg-Bitterfeld (Horizontalstudie)
Creators: name: Kabisch, Andrea Sybille
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2012
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 611

description: Die Arbeit umfasst die Analyse polymorpher Varianten von neun ausgewählten Risiko-Kandidaten-Genen (ACE, Angiotensinogen, Apo E, LRP1, E-Selektin, Faktor V, G-Protein und p22 phox), welche mit der Entstehung von Herz-Kreislauf-Erkrankungen in Verbindung gebracht werden, bei mitteldeutschen Blutspendern der Region Halle-Merseburg-Bitterfeld. Die Betrachtung erfolgte in Abhängigkeit von Alter und Geschlecht und beinhaltete den Vergleich eigener Ergebnisse mit den Resultaten internationaler Publikationen. Nach Genotypisierung von 442 Blutproben gesunder Blutspender (271 Männer, 171 Frauen) des Universitäts-Blutspendedienstes Halle und molekulargenetischen Untersuchungen mittels PCR- und RFLP-Techniken wurden mehrere alters- und geschlechtsabhängige Verteilungsunterschiede innerhalb der Probanden nachgewiesen, welche auf Selektionseffekte im Blutspenderpool hindeuten. Bemerkenswerte Unterschiede ergaben sich im internationalen Vergleich mit japanischen Populationen. Bei vier der untersuchten Polymorphismen fand sich bei Japanern die geringste Anzahl von Trägern der als auffällig betrachteten Gen-Varianten.
description: The work includes the analysis of polymorphic variants of nine selected risk-candidate genes (ACE, angiotensinogen, Apo E, LRP1, E-selectin, Factor V, G protein and p22 phox), which be associated with the emergence of cardiovascular disease, in a group of blood donor of the central German region Halle-Merseburg and Bitterfeld. The analysis was carried out according to age and gender and included the comparison of own results with those of international publications. After genotyping of 442 blood samples from healthy blood donors (271 men, 171 women) of the University Blood Transfusion Service Halle and molecular genetic studies using PCR and RFLP techniques, several age-and sex-dependent distribution differences were detected in the subjects, which indicate selection effects in the blood donor pool. Notable differences were found in an international comparison with Japanese populations. In four of the investigated polymorphisms the least number of carriers of the gene variants considered to be conspicuous was found in Japanese.
Childhood allergic rhinitis : the role of the environment and genetics
Creators: name: Fuertes, Elaine Isabelle
Publisher: name: University of British Columbia
Year: 2014

description: Allergic rhinitis is a global health problem that causes major illness and disability. Inherited and environmental factors influence its development. This thesis examined the role of traffic-related air pollution, genetic variants and their potential interactions, on childhood allergic rhinitis. Global spatial associations with climatic factors known to influence aeroallergen distributions were also studied. Data from two Canadian (CAPPS and SAGE) and four European birth cohorts (BAMSE, GINIplus, LISAplus and PIAMA) participating in the Traffic, Asthma and Genetics collaboration were pooled. No consistent associations between individual-level traffic-related air pollutants (NO2, PM2.5 mass, PM2.5 absorbance and ozone) estimated to the home address and childhood allergic rhinitis were observed in a longitudinal analysis (up to ten years) of two cohorts (GINIplus and LISAplus; N=6,604) and a pooled analysis of all six cohorts (N=15,299). These latter null associations were not modified by ten tested single nucleotide polymorphisms in the GSTP1, TNF, TLR2 and TLR4 genes. Although these results do not support an adverse role of traffic-related air pollution on childhood allergic rhinitis, much remains to be learned regarding for whom, when and how air pollution may impact disease. In further analyses, genetic variants in the TNF and TLR4 genes and at the 17q21 gene locus were found to be associated with childhood allergic rhinitis in pooled analyses of the six cohorts. As genetic variability in these regions has also been linked to asthma, the observed associations support the hypothesis of shared genetic susceptibility between asthma and allergic rhinitis. These results may be important for public health given the large proportion of the population carrying the studied risk variants. Lastly, using cross-sectional data from 6-7 and 13-14 year-olds participating in the International Study of Asthma and Allergies in Childhood, several ecological spatial associations between climatic factors (temperature, precipitation and vapour pressure) and intermittent and persistent rhinitis symptom prevalences were identified. Although not conclusive, these results represent a first step in investigating how climate change may affect rhinitis symptom prevalence. Collectively, this dissertation contributes to our understanding of the effects of air pollution, genetic variability and climate on childhood allergic rhinitis.
Kardioprotektive Effekte des Bone Morphogenetic Protein 2 im Herzinfarktmodell der Maus
Creators: name: Hillebrand, Ina Dorothea
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2011
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 611

description: Der akute Myokardinfarkt (AMI) ist eine der Haupttodesursachen in den westlichen Industrienationen. Der Einsatz von Behandlungsstrategien, die zu einer schnellen Reperfusion des ischämischen Myokards führen, hat in den letzten Jahren die Letalität des AMI gesenkt. Dennoch liegt auch unter idealen Bedingungen zwischen Infarktdiagnose und kompletter Reperfusion des Myokards eine kritische Zeitspanne, in der zusätzliche Verfahren zur Myokardprotektion eingesetzt werden könnten. Verschiedene Strategien der Präkonditionierung führen in tierexperimentellen Untersuchungen zu einer Verbesserung der myokardialen Ischämietoleranz. Die vorliegende Arbeit umfasst Untersuchungen bezüglich protektiver Effekte des Bone morphogenetic protein 2 (BMP2) auf Kardiomyozyten unter Stressbedingungen. In Zellkulturexperimenten wurde der Einfluss von BMP2 auf die Schlagfrequenz und Kontraktilität von isolierten neonatalen Rattenkardiomyozyten sowie auf die Apoptoserate adulter Kardiomyozyten unter Hypoxie bzw. in Gegenwart von H2O2 untersucht. In einem in vivo-Modell wurde BMP2 adulten ICRMäusen 30 Minuten vor der Induktion eines Myokardinfarktes intravenös appliziert, und die daraus resultierenden Veränderungen wurden mittels serieller Echokardiographie sowie durch histologische Untersuchungen erfasst. Weiterhin wurden Teile der Lunge, der Leber und des Zwerchfells lichtmikroskopisch auf pathologische Veränderungen geprüft. Im Ergebnis zeigt sich, dass BMP2 das Überleben der Versuchstiere nach einem akuten Myokardinfarkt verbessert. Insbesondere Tiere mit sehr großen Infarkten, die in der Kontrollgruppe bereits früh nach der Infarktinduktion versterben, überleben nach BMP2-Gabe. Anhalt für unerwünschte Wirkungen, wie ektope Verknöcherungen oder eine gesteigerte interstitielle Fibrose in benachbarten Organsystemen (Lunge, Leber und Zwerchfell) finden sich hierbei nicht. Die Zellkulturexperimente belegen, dass die Gabe von BMP2 unter Bedingungen von erhöhtem oxidativen Stress antiapoptotische Effekte entfaltet, die Hypoxie-Resistenz von Kardiomyozyten verbessert und zu kontraktilitätssteigernden Effekten an isolierten Kardiomyozyten führt. Daher könnte die Gabe von BMP2 möglicherweise einen vielversprechender Therapieansatz zur Myokardprotektion darstellen.
Constructing Carmichael numbers through improved subset-product algorithms
Creators: name: Alford, W. R.
name: Grantham, Jon
name: Hayman, Steven
name: Shallue, Andrew
Publisher: name: arXiv
Year: 2012
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11Y16

description: We have constructed a Carmichael number with 10,333,229,505 prime factors, and have also constructed Carmichael numbers with k prime factors for every k between 3 and 19,565,220. These computations are the product of implementations of two new algorithms for the subset product problem that exploit the non-uniform distribution of primes p with the property that p-1 divides a highly composite Λ.
description: Table 1 fixed; previously the last 30 digits and number of digits were calculated incorrectly
Entwicklung und Validierung eines Direkt-Radioimmunoassays zur quantitativen Bestimmung von Gesamt-Melatonin (N-Acetyl-5-methoxytryptamin) bei unterschiedlichen Mauslinien
Creators: name: Welp, André
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2010
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 611

description: Die bisher publizierten Methoden zur Bestimmung von Melatonin bei verschiedenen Mausmodellen waren überwiegend ungeeignet oder aufwendig in der Durchführung. Im Rahmen dieser Arbeit wurde ein einfacher, sensitiver und spezifischer Radioimmunoassay (RIA) für die quantitative Detektion von Gesamt-Melatonin in Serum- bzw. Plasmaproben bei unterschiedlichen Mauslinien entwickelt. Durch die Herstellung einer spezifischen Mausausgleichsmatrix wird die Beeinflussung von Messergebnissen aufgrund unterschiedlicher Zusammensetzung zwischen Standards und Probenmatrix verringert. Mit einem geeigneten Syntheseverfahren zur Herstellung eines Immunisierungskonjugats ist es gelungen, einen spezifischen Antikörper gegen Melatonin zu generieren. Der Test erfasst das gesamte Melatonin, weil mit der Einführung eines Enzymschritts das an Proteine gebundene Melatonin getrennt wird. Die Markierung mit [125I]-Bolton-Hunter-Reagenz ist ein effektives Verfahren zur Einführung radioaktiven Iods in eine Vielzahl verschiedener Proteine, Peptide und Moleküle mit Amino-Gruppen. Die geforderten Akzeptanzkriterien für die Validierungsparameter wurden erfüllt. Ein diurnaler Rhythmus des Melatonins in Serum- und Plasmaproben von Kontroll-Mäusen konnte erfasst werden. Die Durchführung beim „Direkt-RIA“ ist gegenüber etablierten Extraktionsmethoden wie Flüssig-Flüssigund Festphasenextraktion sowie anschließendem RIA, wesentlich schneller. Mit dem „Direkt-RIA“ konnte der Nachweis einer nächtlich erhöhten Melatoninsynthese bei vier unterschiedlichen Mauslinien erbracht werden. Die Melatonin-Bestimmungen mittels ELISA- oder HPLC-Techniken scheiterten bisher am Gebrauch eines hohen Probenvolumens und geringerer Sensitivität. Zusammenfassend können folgende Vorteile des „Direkt-RIA“ hervorgehoben werden: Einfache und schnelle Durchführung des Assays, höhere Anfangsaktivität des Tracers, weiter Arbeitsbereich, hohe Spezifität des Antikörpers, niedriges Probenvolumen und hohe Sensitivität. Tagesrhythmen von Melatonin mit erhöhten Melatoninwerten in der Nacht können mit dem „Direkt-RIA“ bei unterschiedlichen Mauslinien nachgewiesen werden.
A pattern theorem for random sorting networks
Creators: name: Angel, Omer
name: Gorin, Vadim
name: Holroyd, Alexander E.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Probability (math.PR)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 60C05, 05E10, 68P10

description: A sorting network is a shortest path from 12..n to n..21 in the Cayley graph of the symmetric group S(n) generated by nearest-neighbor swaps. A pattern is a sequence of swaps that forms an initial segment of some sorting network. We prove that in a uniformly random n-element sorting network, any fixed pattern occurs in at least cn^2 disjoint space-time locations, with probability tending to 1 exponentially fast as n tends to infinity. Here c is a positive constant which depends on the choice of pattern. As a consequence, the probability that the uniformly random sorting network is geometrically realizable tends to 0.
description: 21 pages, 9 figures. Final journal version
Near critical catalyst reactant branching processes with controlled immigration
Creators: name: Budhiraja, Amarjit
name: Reinhold, Dominik
Publisher: name: arXiv
Year: 2012
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: Near critical catalyst-reactant branching processes with controlled immigration are studied. The reactant population evolves according to a branching process whose branching rate is proportional to the total mass of the catalyst. The bulk catalyst evolution is that of a classical continuous time branching process; in addition there is a specific form of immigration. Immigration takes place exactly when the catalyst population falls below a certain threshold, in which case the population is instantaneously replenished to the threshold. Such models are motivated by problems in chemical kinetics where one wants to keep the level of a catalyst above a certain threshold in order to maintain a desired level of reaction activity. A diffusion limit theorem for the scaled processes is presented, in which the catalyst limit is described through a reflected diffusion, while the reactant limit is a diffusion with coefficients that are functions of both the reactant and the catalyst. Stochastic averaging principles under fast catalyst dynamics are established. In the case where the catalyst evolves "much faster" than the reactant, a scaling limit, in which the reactant is described through a one dimensional SDE with coefficients depending on the invariant distribution of the reflected diffusion, is obtained. Proofs rely on constrained martingale problem characterizations, Lyapunov function constructions, moment estimates that are uniform in time and the scaling parameter and occupation measure techniques.
description: Published in at http://dx.doi.org/10.1214/12-AAP894 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Additional file 1 of Labor induction in China: a nationwide survey
Creators: name: Zhu, Jing
name: Xue, Lili
name: Shen, Huaxiang
name: Zhang, Lin
name: Lu, Danni
name: Wang, Yanlin
name: Zhang, Yu
name: Zhang, Jun
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Additional file 1: Table S1. Associations between sociodemographic characteristics and cesarean delivery in women undergoing labor induction in China. Table S2. Gestational weeks at delivery and vaginal delivery rate among women undergoing labor induction in China. Table S3. Attempted mode of delivery by geographical regions in China. Table S4. Association of prelabor cesarean delivery rate and labor induction rate in China. Table S5. Comparison of maternal characteristics between low-risk women undergoing labor induction and prelabor cesarean delivery in China.
Categorified quantum sl(2) is an inverse limit of flag 2-categories
Creators: name: Beliakova, Anna
name: Lauda, Aaron D.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics
subject: 20G42, 14M15, 17B37, 16W50

description: We prove that categorified quantum sl(2) is an inverse limit of Flag 2-categories defined using cohomology rings of iterated flag varieties. This inverse limit is an instance of a 2-limit in a bicategory giving rise to a universal property that characterizes the categorification of quantum sl(2) uniquely up to equivalence. As an application we characterize all bimodule homomorphisms in the Flag 2-category and prove that the categorified quantum Casimir of sl(2) acts appropriately on these 2-representations.
description: 21 pages, with xypic diagrams. v2 corrects typos
Deep inelastic scattering of baryons in a modified soft wall model
Creators: name: Braga, Nelson R. F.
name: Vega, Alfredo
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We calculate the structure functions for unpolarized deep inelastic scattering of baryons using an AdS/QCD soft wall model that considers a dressed mass for the bulk fermionic fields. Considering the regime of large Bjorken parameter x, we compare the results for the proton structure function $F_2$ with experimental results.
description: We improved the comparison with experimental data and included more references, version to appear in EPJC
Verstärkung einer IL-2-initiierten Immunantwort gegen eine Zelllinie der Ewing-Tumor-Familie durch Stimulation des kostimulatorischen Rezeptors CD137
Creators: name: Kühnöl, Caspar David
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2010
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 611

description: Ziel dieser Arbeit war zu untersuchen, in wieweit die Immunantwort von mononukleären Zellen des peripheren Blutes (PBMC) gegen eine Ewing-Tumor-Zelllinie (A673) durch Stimulation des kostimulatorischen Rezeptors CD137 (Antikörper gegen CD137 oder CD137L-transfizierte Tumorzellen) in Kombination mit Interleukin 2 (IL-2) verändert werden kann und welche Gene eventuell beteiligt sind. Es zeigte sich eine verstärkte Aktivierung, Zytotoxizität und erhöhte Sekretion von Interferon gamma und Granzym B von PBMC durch die Kombination von IL-2 und Stimulation des Rezeptors CD137 (im Vergleich zur Stimulation nur mit IL-2). In einem NOD/SCID-Mausmodell zeigte sich zeitweise ein verzögertes Wachstums der so behandelten Tumoren. In Mikroarray-Untersuchungen wurden Gene erfasst, die im Zusammenhang mit einer gesteigerten Immunantwort stehen könnten. Mithilfe der Stimulation des Rezeptors CD137 konnte eine IL-2-initiierte Immunantwort gegen Zellen einer Ewing-Tumor-Zelllinie gesteigert werden.
About adaptive coding on countable alphabets
Creators: name: Bontemps, Dominique
name: Boucheron, Stéphane
name: Gassiat, Elisabeth
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: This paper sheds light on universal coding with respect to classes of memoryless sources over a countable alphabet defined by an envelope function with finite and non-decreasing hazard rate. We prove that the auto-censuring AC code introduced by Bontemps (2011) is adaptive with respect to the collection of such classes. The analysis builds on the tight characterization of universal redundancy rate in terms of metric entropy % of small source classes by Opper and Haussler (1997) and on a careful analysis of the performance of the AC-coding algorithm. The latter relies on non-asymptotic bounds for maxima of samples from discrete distributions with finite and non-decreasing hazard rate.
Data Nyayu Aisyah.zip
Creators: name: Aisyah, Nyayu
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 401906
subject: Nuclear engineering (incl. fuel enrichment and waste processing and storage)
classificationCode: 401105
subject: Life cycle assessment and industrial ecology

description: This data for the manuscript LCA for Indonesian NPP
Particle collisions in the lower dimensional rotating black hole space-time with the cosmological constant
Creators: name: Yang, Jie
name: Li, Yun-Liang
name: Li, Yang
name: Wei, Shao-Wen
name: Liu, Yu-Xiao
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper, we study the effect of ultra-high energy collisions of two particles with different energies near the horizon of a 2+1 dimensional BTZ black hole (BSW effect). We find that the particle with the critical angular momentum could exist inside the outer horizon of BTZ black hole regardless of the particle energy. Therefore, for the non-extremal BTZ black hole, the BSW process is possible on the inner horizon with the fine tuning of parameters which are characterized by the motion of particle. While for the extremal BTZ black hole, the particle with the critical angular momentum could only exist on the degenerate horizon, and the BSW process could also happen there.
description: 12 pages,3 figures
Histochemische Darstellung der Tyrosinase in Liquorleukozyten bei neurologischen Erkrankungen
Creators: name: Schulze, Jürgen
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2009
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 611

description: In der hier vorliegende Arbeit sollte geklärt werden ob und bei welchen neurologischen Erkrankungen sich das Enzym Tyrosinase in Liquorzellen nachweisen lässt, ob bei einer Pleozytose die Tyrosinase-positive Zellen nachweisbar sind, ob es Unterschiede bei Autoimmunerkrankungen und Infektionserkrankungen gibt und ob die Bestimmung der Tyrosinase-positiver Zellen als Routinetest von diagnostischer Relevanz wäre. Die histochemische Nachweisreaktion beruht auf der Oxidation des L-Dihydroxyphenylalanin (DOPA), das als Substrat angeboten wurde, zu DOPA-Chinon, welches in Gegenwart von Sauerstoff spontan zu Melanin umgewandelt wird. Dieses Melanin ist an seiner braunen bis tiefschwarzen Farbe zu erkennen. Mit dieser Enzymdarstellung (mit und ohne Pappenheim-Gegenfärbung) wurden die Liquorzellen bei 292 Patienten mit neurologischen Erkrankungen untersucht. Zur Auswertung kamen 204 Liquor-Präparate von 187 Patienten. Der Tyrosinasenachweis gelang bei bakteriellen Erkrankungen und bei positivem Toxoplasmose-Titer zu Krankheitsbeginn bzw. bei der Erstuntersuchung fast ausnahmslos. Bei Patienten mit Tumoren des ZNS und Tumoren mit ZNS-Beteiligung konnten Tyrosinase -positive Zellen gefunden werden, während Kranke mit Wirbelsäulen-Tumoren im Gegensatz dazu keine Tyrosinase -positive Zellen im Liquor zeigten. Bei fünf von 14 Patienten mit sicherer Multiple Sklerose wurde einen Tyrosinase –positive Zellen nachgewiesen. Keine Tyrosinase -positive Zellen fanden sich bei viralen Erkrankungen, zerebro- vaskulären Prozessen, Epilepsien, Wurzelreizungen und degenerativen Erkrankungen. Schlußfolgernd kann gesagt werden, daß das Enzym Tyrosinase auch bei zellvermittelten Immunreaktionen gegen Bakterien und Protozoen (hier Toxoplasmen) sowie in der Tumorerkrankungen des ZNS auch beim Menschen eine Rolle zu spielen scheint. Allerdings scheint der Einsatz in der Routinediagnostik nicht gerechtfertigt.
Struktur-Effekt-Analysen neuer Cisplatinkonjugate unter spezieller Berücksichtigung der Cisplatinresistenz bei Keimzelltumoren
Creators: name: Behlendorf, Timo
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2012
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 611

description: Für diese Arbeit erfolgte die Untersuchung der Zytotoxizität 12 neuer Platinkonjugate THP 1-12 (cis-Dichloro(m-{n-[(tetrahydro-2H-pyran-2-yl)oxy]Alkyl1}Alkyl2-diamino)platin(II)-Verbindungen; Alkyl1:-butyl/-hexyl/-octyl/-undecyl; Alkyl2:-ethan/-propan) im Keimzelltumormodell, die Bestätigung der Apoptoseinduktion sowie die Charakterisierung der Einflüsse auf den Zellzyklus. Die Versuche wurden an den Zelllinien H12.1 (cisplatinsensibel) und 1411HP (cisplatinresistent) in vitro durchgeführt. Die Zytotoxizitäts-Untersuchung erfolgte mittels Sulforhodaminrot B-Assay. Die Apoptoseinduktion wurde mittels DNA-Fragmentierungsnachweis untersucht. Die Zellzyklusanalyse erfolgte durchflusszytometrisch. Die Seitenkettenlänge der Substanzen korrelierte mit deren Toxizität. Für THP12 konnte eine Überwindung der Cisplatinresistenz in der Zelllinie 1411HP nachgewiesen werden. Die DNA-Elektrophorese bestätigte die Apoptoseinduktion. Die Zellzyklusanalyse ergab eine im Vergleich zu Cisplatin schnellere Apoptoseinduktion ohne vorherigen G2/M-Arrest.
title: Mussolini, Benito
title: Mussolini, Benito
Creators: name: Sullivan, Brian R.
Publisher: name: BSB - Bavarian State Library
Year: 2017
Subjects: subject: Mussolini, Benito
subject: Mussolini, Benito, 1883-1945

description: Italian Socialist Benito Mussolini envisioned war as the prerequisite for revolution. He helped push Italy into World War I. After combat service and medical discharge in 1917, he demanded war until victory. In 1919, he founded the Fascist movement. Using veterans to smash political opposition, he seized power in October 1922.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Kinetic and chemical equilibrium of the Universe and gravitino production
Creators: name: Rangarajan, Raghavan
name: Sarkar, Anjishnu
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Flat directions in generic supersymmetric theories can change the thermal history of the Universe. A novel scenario was proposed earlier where the vacuum expectation value of the flat directions induces large masses for all the gauge bosons and gauginos. This delays the thermalization of the Universe after inflation and solves the gravitino problem. In this article we perform a detailed calculation of the above scenario. We include the appropriate initial state particle distribution functions, consider the conditions for the feasibility of the non-thermal scenario, and investigate phase space suppression of gravitino production in the context of heavy gauge bosons and gauginos in the final state. We find that the total gravitino abundance generated is consistent with cosmological constraints.
description: 40 pages, 10 figures, published version with several changes including in conclusion
Supporting decision-making in whole genome/exome sequencing : parents' perspectives
Creators: name: Li, Karen Christine
Publisher: name: University of British Columbia
Year: 2014

description: Whole genome sequencing/exome sequencing (WGS/ES) technology is becoming more affordable and accessible, and will become more frequently used in various clinical settings, including for diagnosing rare childhood diseases. However, its use means that parents face decisions that could uncover life-altering information, unrelated to their child’s illness that may also have personal and ethical implications for their families. The purpose of this study is to explore and describe parents’ perceptions of their decisional needs when deciding on WGS/ES for their child. The qualitative methodological approach known as Interpretive Description, the concept of shared decision-making and the Ottawa Decision Support Framework were used to inform and guide this study. Parents of children who had previously undergone WGS/ES informed consent were invited to participate in a focus group or individual in-person or telephone interviews. Parents had children with a range of undiagnosed conditions suspected to be genetic in origin. 15 parents were interviewed and transcriptions were analyzed concurrently and iteratively. Repeat interviews were conducted with 5 of the parents to confirm, challenge or expand on the developing conceptualizations. Participants felt that their decision to proceed with WGS/ES for their child was easy. However, they expressed many unresolved decisional needs including: a lack of knowledge about certain topics that became relevant and important to them later, unmet expectations, and a need for more support and resources. Participants also acknowledged that the high volume of information and urgency of their circumstances may have caused them to be less receptive (or even unreceptive) to information during their WGS/ES decision-making (DM) process. Additionally, participants had ongoing informational and psychosocial needs beyond the single clinical encounter where their WGS/ES DM occurred. The content and amount of information that participants considered to be important varied. Prior to the widespread use of clinical WGS/ES, parents’ perspectives about their decisional needs should be considered in order to implement parent-tailored education, counselling, decision support and informed consent processes.
Coarse grained approach for universality classification of discrete models
Creators: name: Buceta, R. C.
name: Hansmann, D.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Discrete and continuous models belonging to a universality class share the same linearities and (or) nonlinearities. In this work, we propose a new approach to calculate coarse grained coefficients of the continuous differential equation from discrete models. We apply small constant translations in a test space and show how to obtain these coefficients from the transformed average interface growth velocity. Using the examples of the ballistic deposition (BD) model and the restricted solid-on-solid (RSOS) model, both belonging to the Kardar-Parisi-Zhang (KPZ) universality class, we demonstrate how to apply our approach to calculate analytically the corresponding coefficients of the KPZ equation. Our analytical nonlinear coefficients are in agreement with numerical results obtained by Monte Carlo tilted simulations. In addition to the BD and the RSOS we study a competitive RSOS model that shows crossover between the KPZ and Edwards-Wilkinson universality classes.
description: 15 pages, 3 figures
Regularity of Semigroups via the Asymptotic Behaviour at Zero
Creators: name: Fackler, Stephan
Publisher: name: arXiv
Year: 2012
Subjects: subject: Analysis of PDEs (math.AP)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 47D06 (Primary) 47D09, 46B70 (Secondary)

description: An interesting result by T. Kato and A. Pazy says that a contractive semigroup (T(t)) on a uniformly convex space X is holomorphic iff limsup_{t \downarrow 0} ||T(t)-Id|| < 2. We study extensions of this result which are valid on arbitrary Banach spaces for semigroups which are not necessarily contractive. This allows us to prove a general extrapolation result for holomorphy of semigroups on interpolation spaces of exponent θ in (0,1). As application we characterize boundedness of the generator of a cosine family on a UMD-space by a zero-two law. Moreover, our methods can be applied to R-sectoriality: We obtain a characterization of maximal regularity by the behaviour of the semigroup at zero and show extrapolation results.
description: 14 pages; final version
Expression und Regulation des antimikrobiellen Peptids Psoriasin an der Augenoberfläche und im Tränenapparat
Creators: name: Gottschalt, Maria
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2013
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 611
subject: 610

description: Das S100 Peptid Psoriasin (S100A7) ist eine antimikrobiell wirksame Substanz, die insbesonders gegen das gram-negative Bakterium Eschericha coli wirkt. Es wurde erstmals in der Haut von Patienten mit Psoriasis beschrieben. In der vorliegenden Arbeit kann gezeigt werden, dass Psoriasin in verschiedenen Geweben der Augenoberfläche und in den ableitenden Tränenwegen unterschiedlich exprimiert wird und eine Regulation durch bestimmte Wachstumsfaktoren, Bakterienüberstände und Zytokine stattfindet. Die Ergebnisse geben Aufschluss über die Wirkung und Eigenschaften von Psoriasin und können helfen, dessen Funktion als Teil der angeborenen Immunabwehr an der Augenoberfläche besser zu verstehen.
description: The 11-kDa Zn²+ -binding peptide, psoriasin, originally isolated from patients with psoriasis as an overexpressed molecule of unknown function, has recently been identified as a principal Escherichia coli-killing antimicrobial peptide of healthy skin. Our results suggest that psoriasin is produced by the structures of the ocular surface, mainly by meibomian glands and lacrimal fluid. It is induced by inflammatory and bacterial stimuli. Moreover, the results suggest that psoriasin is part of the innate immune system at the ocular surface and tear film.
Measure solutions for some models in population dynamics
Creators: name: Cañizo, José A.
name: Carrillo, José A.
name: Cuadrado, Sílvia
Publisher: name: arXiv
Year: 2011
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35Q92, 92D15, 92D25

description: We give a direct proof of well-posedness of solutions to general selection-mutation and structured population models with measures as initial data. This is motivated by the fact that some stationary states of these models are measures and not $L^1$ functions, so the measures are a more natural space to study their dynamics. Our techniques are based on distances between measures appearing in optimal transport and common arguments involving Picard iterations. These tools provide a simplification of previous approaches and are applicable or adaptable to a wide variety of models in population dynamics.
description: 15 pages. An error in the proof of Theorem 3.5 has been corrected
List of Classification Categories
Creators: name: Santos, Rubens
name: Groen, Eduard C.
name: Villela, Karina
Publisher: name: Zenodo
Year: 2019
Subjects: requirements engineering, natural language processing

description: Bibliography of primary studies for the NLP4RE 2019 paper "A Taxonomy for User Feedback Classifications". Available in the CEUR Workshop Proceedings for the REFSQ'19 Collocated Events.
title: Mémorial Interallié
title: Mémorial Interallié
Creators: name: Vanraepenbusch, Karla
Publisher: name: BSB - Bavarian State Library
Year: 2017
Subjects: subject: Mémorial Interallié (Lüttich)
subject: World War, 1914-1918--Monuments
subject: Belgium

description: The inter-allied memorial commemorates the First World War and the fallen, as well as the wartime cooperation between the Allies. Its inter-allied character and its scale make this memorial one of a kind.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Data assimilation in the low noise regime with application to the Kuroshio
Creators: name: Vanden-Eijnden, Eric
name: Weare, Jonathan
Publisher: name: arXiv
Year: 2012
Subjects: subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: On-line data assimilation techniques such as ensemble Kalman filters and particle filters lose accuracy dramatically when presented with an unlikely observation. Such an observation may be caused by an unusually large measurement error or reflect a rare fluctuation in the dynamics of the system. Over a long enough span of time it becomes likely that one or several of these events will occur. Often they are signatures of the most interesting features of the underlying system and their prediction becomes the primary focus of the data assimilation procedure. The Kuroshio or Black Current that runs along the eastern coast of Japan is an example of such a system. It undergoes infrequent but dramatic changes of state between a small meander during which the current remains close to the coast of Japan, and a large meander during which it bulges away from the coast. Because of the important role that the Kuroshio plays in distributing heat and salinity in the surrounding region, prediction of these transitions is of acute interest. Here we focus on a regime in which both the stochastic forcing on the system and the observational noise are small. In this setting large deviation theory can be used to understand why standard filtering methods fail and guide the design of the more effective data assimilation techniques. Motivated by our analysis we propose several data assimilation strategies capable of efficiently handling rare events such as the transitions of the Kuroshio. These techniques are tested on a model of the Kuroshio and shown to perform much better than standard filtering methods.
description: 43 pages, 12 figures
title: Forts
title: Forts
Creators: name: Lopez, Miguel A.
Publisher: name: BSB - Bavarian State Library
Year: 2017
Subjects: subject: Festung
subject: Weltkrieg [1914-1918]
subject: World War, 1914-1918
subject: Fortification

description: European militaries considered fortifications before the First World War as vital to their strategic planning. Advancements in weapons technology after the mid-19th century caused engineers to upgrade their forts or face obsolescence. Although fortresses had an uneven record of success during the war, some European military leaders continued to value them.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Einfluss von Survivin, VEGF-C und Carboanhydrase IX auf die Prognose des Plattenepithelkarzinoms der Mundhöhle
Creators: name: Bolte, Katharina
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2013
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 610
subject: 616

description: In den letzten Jahren hat sich die 5-Jahres-Überlebensrate des Mundhöhlenkarzinoms trotz Einführung neuer diagnostischer und therapeutischer Maßnahmen nicht wesentlich verbessert. Anhand von immunhistochemischen Färbungen an 75 Paraffinschnitten von Mundhöhlenkarzinomen wurde die Expression der tumorrelevanten Proteine Survivin vascular endothelial growth factor (VEGF-C) und Carboanhydrase IX (CAIX) untersucht und mit den klinisch-pathologischen Daten sowie der 5-Jahres-Überlebensrate korreliert, um den Einfluss der drei Proteine auf die Prognose der Erkrankung zu untersuchen. In der singulären Betrachtung der drei Proteine ließ sich kein signifikant erhöhtes Risiko am Tumor zu versterben nachweisen. Die kombinierte Analyse aller drei Proteine konnte jedoch ein signifikant 5,1fach erhöhtes Risiko des tumorassoziierten Versterbens bei starker Expression von Survivin und CAIX und gleichzeitig schwacher Expression von VEGF-C nachweisen. Das Survivin scheint ein vielversprechender Marker zur Prognoseabschätzung zu sein. Es besteht Hoffnung, dieses Protein zur Prognoseabschätzung des Plattenepithelkarzinoms der Mundhöhle und zur Therapiestratifizierung heranziehen zu können.
description: Over the past years the 5-year survival rate of oral squamous cell carcinoma has not improved substantially despite of the introduction of new diagnostic and therapeutic measures. Using immunohistochemical staining of 75 fixed paraffin sections of oral squamous cell carcinoma the expression of tumor-related proteins survivin, vascular endothelial growth factor (VEGF-C) and carbonic anhydrase IX (CAIX) has been studied. The results has been correlated with clinicopathological data and 5-year survival rate to investigate the influence of the three descripted proteins onto prognosis of the disease. Singular observation of the three proteins revealed no significant increased risk of conditional tumor-decease. However, the combined analysis of all three proteins was able to demonstrate a significant 5.1-fold increased risk of tumor-associated decease, when survivin and CAIX were strongly expressed, while VEGF-C showed weak expression.
Biodiversity of Arctic char (Salvelinus alpinus) : sympatric morphs and hybridization with Dolly Varden (S. malma) in southwestern Alaska
Creators: name: May-McNally, Shannan Leigh
Publisher: name: University of British Columbia
Year: 2014

description: Resource polymorphism and natural hybridization are evolutionary phenomena that play an important role in the development of reproductive isolation during speciation. The Arctic char (Salmonidae: Salvelinus alpinus) exhibits substantial phenotypic and genetic diversity across its Holarctic range, making it an ideal species to examine the role of intraspecific trophic polymorphism in driving reproductive isolation and the interactions between hybridizing species in sympatry. In one southwestern post-glacial lake previously analyzed for resource polymorphism (Lower Tazimina Lake), I found evidence for two genetic groups of char and for significant differences in the distribution of microsatellite variability among at least two of the three previously described body-size morphotypes (‘large’, ‘medium’, and ‘small’–bodied char; maximum FST = 0.09). I also found significant associations between genetic type and gill raker counts among body-size morphs (r = -0.73, P < 0.001). These data represent the first record of genetically distinct sympatric Arctic char morphs in Alaska and provides further evidence that morphological differences associated with feeding and growth trajectories reflect niche diversification and may promote genetic divergence. Furthermore, I evaluated the level of natural hybridization and ecological segregation between two sympatric sister species of char, Arctic char and Dolly Varden (Salvelinus malma), from two southwestern Alaskan lakes. A total of N = 725 char were collected from 44 microhabitats across two lakes (Lake Aleknagik and Lake Nerka) and genotyped at 13 microsatellite loci. Using genetic admixture (Q)-values generated through Bayesian-based clustering, hybridization levels between Arctic char and Dolly Varden were found to be minimal; less than 0.5% of samples were classified as hybrids. Concurrent analyses with NEWHYBRIDS, however, supported the presence of late-generation hybrids in Lake Aleknagik with up to 7% of all samples representing F₂ hybrids or backcrossed Dolly Varden. The existence of two discrete gene pools in sympatry (FST= 0.172–0.187 across the two lakes) which were generally spatially separate and low levels of contemporary hybridization between Arctic char and Dolly Varden helps to solidify their taxonomic status as distinct biological species. Moreover, high levels of reproductive isolation between these sympatric species may be driven largely by strong pre-mating spatial segregation.
The targum (1871:Apr.)
Creators: name: No Name Supplied
Publisher: name: Targum Association
Year: 1871

description: Some University historians indicate that the Targum was first published as an annual in 1867, but of this we have no extant evidence. In January 1869, the Targum as we now know it, made its appearance as a monthly paper that concerned itself with student “literary contributions” and college news as well as serving as a vehicle for bringing news to alumni and the general public. The newspaper, which originally was for sale, varied in frequency over the years as did its title (The Targum, Rutgers Targum, Rutgers Daily Targum, and Daily Targum). The newspaper has continuously been published since 1869 with the exception of 19 months during the second world war, between February 1944 and October 1945. The Targum was published by the students of Rutgers College, and later Rutgers University—New Brunswick represented through the years as the Targum Association, Rutgers Targum Association, and Rutgers College Targum. As a student organization, the Targum operated under the oversight of the dean of students and student government but in October 1980, the Targum became an independent college paper.