cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sunday Chronicle (Paterson, NJ) Vol. 28, No. 12, March 18, 1956
Creators: name: Parrillo, Vincent N.
Publisher: name: The Chronicle Company
Year: 1956

description: Local information pertaining to Paterson, N.J. and surrounding Passaic County. Issues may include events, government, business, political cartoons, engagement and marriage announcements, and birth announcements.  Originally a weekly newspaper, The Sunday Chronicle suspended publication in 1942 because of a manpower and paper shortage, and then began publication again in 1951 as a weekly magazine until 1965.  This publication was also known as the Paterson Chronicle (1952) and the Paterson Sunday Chronicle (1951-1952).  It was North Jersey’s only weekly magazine in its time,  and the first New Jersey publication to carry weekly television listings.
Nanotherapeutics for refractory brain metastasis in EGFR-mutant lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths in the US and worldwide. In NSCLC patients whose tumors harbor gain-of-function EGFR mutations, EGFR tyrosine kinase inhibitors (TKIs) induce tumor response in 60-80% patients with a median survival of approximately 20-30 months. However, the incidence of brain metastases, either at the initial presentation or during the disease course, has been rising to over 50% with increasing incidence of leptomeningeal metastasis. Whole brain radiation therapy is the current standard-of-care for the majority of these patients, which improves neurological symptoms; however, long-term treatment-related toxicities are debilitating and the treatment does not alter the overall survival. Our research team has successfully developed an on-demand, multifunctional disulfide cross-linked micelle (DCM) nanodrug delivery system that could cross the blood-brain barrier for treating intracranial tumors. The objective of this proposal is to optimize and characterize a multifunctional DCM with a core encapsulating second-generation EGFR TKI afatinib and chemotherapeutic paclitaxel and a surfaceconjugated with high-affinity integrin ligands for targeting EGFR mutant lung cancer. We anticipate this novel multifunctional nanotherapeutic will be more effective and less toxic than afatinib or paclitaxel alone in treating both systemic and intracranial EGFR mutant lung cancer.
Sunday Chronicle (Paterson, NJ) Vol. 28, No. 11, March 11, 1956
Creators: name: Parrillo, Vincent N.
Publisher: name: The Chronicle Company
Year: 1956

description: Local information pertaining to Paterson, N.J. and surrounding Passaic County. Issues may include events, government, business, political cartoons, engagement and marriage announcements, and birth announcements.  Originally a weekly newspaper, The Sunday Chronicle suspended publication in 1942 because of a manpower and paper shortage, and then began publication again in 1951 as a weekly magazine until 1965.  This publication was also known as the Paterson Chronicle (1952) and the Paterson Sunday Chronicle (1951-1952).  It was North Jersey’s only weekly magazine in its time,  and the first New Jersey publication to carry weekly television listings.
Rapid measurement of enzyme conversion rates in liver tumors with hyperpolarized 13C MRI
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Hyperpolarized carbon-13 MRI is a new imaging modality allows for rapid assessment of the tissue metabolic profile non-invasively and without any ionizing radiation. Following an injection of hyperpolarized 13C-labelled pyruvate, conversion to lactate, alanine and bicarbonate/CO2 is observed, where the conversion to lactate is upregulated in cancer due to the Warburg effect. Preclinical results in liver tumors have also indicated that the conversion to alanine is upregulated prior to solid tumor formation. Current in vivo hyperpolarized carbon-13 MRI methods only measure a pseudo-flux in which the forward and reverse enzymatic conversion rates, and cellular transport are lumped together. My group has recently developed a novel in vivo hyperpolarized carbon-13 MRI method that offers the unique ability to accurately quantify bidirectional enzymatic conversion rates while suppressing the effects of perfusion and transport. In this project, we aim to apply this technique in a new direction to study disease progression in a double transgenic MYC-driven liver cancer model. We believe this will provide a substantially improved assessment of the metabolic profile and thus a better understanding of the underlying metabolic processes in liver tumor development. Ultimately, this technique has the potential for clinical translation, as a recent Phase I clinical trial in 31 prostate cancer patients at UCSF with hyperpolarized 13C-pyruvate was shown to be safe and feasible. Accurate quantification of enzymatic conversion rates is crucial in the clinic in order to be able to distinguish aggressive from indolent disease or to reliably monitor therapeutic response.
Sunday Chronicle (Paterson, NJ) Vol. 28, No. 10, March 4, 1956
Creators: name: Parrillo, Vincent N.
Publisher: name: The Chronicle Company
Year: 1956

description: Local information pertaining to Paterson, N.J. and surrounding Passaic County. Issues may include events, government, business, political cartoons, engagement and marriage announcements, and birth announcements.  Originally a weekly newspaper, The Sunday Chronicle suspended publication in 1942 because of a manpower and paper shortage, and then began publication again in 1951 as a weekly magazine until 1965.  This publication was also known as the Paterson Chronicle (1952) and the Paterson Sunday Chronicle (1951-1952).  It was North Jersey’s only weekly magazine in its time,  and the first New Jersey publication to carry weekly television listings.
Synergistically integrated nanosensors for the detection of lung cancer mutation
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Objectives: Lung cancer is a leading cause of cancer-related deaths worldwide, but the survival rate of lung cancer patients can be significantly improved by early stage diagnosis. Since the genetic mutation occurs frequently in cancer patients at their early stages, detection of circulating cancer DNA in blood can be used as an efficient cancer biomarker. However, the amount of cancer DNA in blood is very low, and thus conventional methods such as microarrays and fluorescence detection do not provide sufficient sensitivity for such diagnostic purpose. Here, we propose a nanotechnology-based ultra-sensitive sensor to detect DNA mutation in lung cancer patients. By taking advantage of the unique properties of the nanosensor, which include i) magnetic concentration effects, ii) highly intense and photostable fluorescence, and iii) distance-dependent near-field surface plasmon fluorescence enhancement effects, we will detect lung cancer DNA with highly improved sensitivity and selectivity. This nanosensor will not only offer a new approach to diagnose lung cancer patients at their early stages but also will have the potential to provide the guidelines for chemotherapy of the cancer patients. Specific aim 1. Construct hybrid nanosensors: To detect low levels of circulating lung cancer DNA with high sensitivity and specificity, we establish a nanosensor integrated with four key functional components: 1) a probe DNA that captures the target DNA causing its conformational change, 2) a nano-magnet for concentrating captured DNAs for magnetic concentration up to 1000-fold, 3) a QD reporting the probe DNA conformation with strongly enhanced fluorescence (10-100 fold compared with conventional organic dyes), and 4) a plasmonic component that controls QD fluorescence via near field interaction with the plasmon (0-5 fold). More specifically, we design a new nanosensor construct, composed of a MPN core surrounded by multiple QD satellite nanoparticles, that are linked by a probe DNA bearing poly-T7 sequences at both 5’- and 3’-ends and complementary sequences of the EGFR mutant DNA. Specific aim 2. Detect EGFR-L858R DNA using nanosensor: Once the nanohybrid is secured, we use the hybrid nanoprobes to detect oligonucleotides bearing EGFR-L858R mutation sequences via either ensemble methods or single-molecule dark field/fluorescence microscopy. We optimize sensing and stringency conditions by varying critical key parameters affecting the DNA hybridization. Finally we determine detection sensitivity and specifici
Parectopa heptametra Meyrick 1915, n. sp.
Creators: name: Prins, Jurate De
name: Brito, Rosângela
name: Moreira, Gilson Rudinei Pires
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Gracillariidae
Parectopa
Parectopa heptametra

description: Parectopa heptametra Meyrick, 1915
" Parectopa hectametra, n. sp. "—Meyrick, E. 1915b. Transactions of the Entomological Society of London
(2): 235.
Type locality: Colombia, La Crumbre, 6000 ft., v.1914. Type specimens: Syntypes 1♂ and 1♀, BMNH.
Distribution: Colombia (Meyrick 1915b: 235).
Larval hostplant(s): Unknown.
description: Published as part of Prins, Jurate De, Brito, Rosângela & Moreira, Gilson Rudinei Pires, 2016, An annotated taxonomic checklist of the Neotropical Gracillariidae (Lepidoptera) with links to the information on host plants and parasitoids, pp. 1-51 in Zootaxa 4158 (1) on pages 28-29, DOI: 10.11646/zootaxa.4158.1.1, http://zenodo.org/record/255480
Assessing SERMs in estrogen-responsive neural circuits controlling locomotion and satiety
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Thousands of women use hormone therapies or selective estrogen modulators (SERMs) to prevent reoccurrence of breast cancer. In 2013, the US Preventative Task Force (www.uspreventiveservicestaskforce.org) also recommended SERMs for women at risk for breast cancer. Although long-term use of SERMs on the cardiovascular system, bone, and uterus are known, rigorous studies defining how different SERMs affect metabolism and neural metabolic circuits have yet to emerge. For women’s health, a comprehensive answer to this question is especially important given the known benefits of estrogen on metabolism. Recently, my lab also found that estrogen signaling via ER alpha promotes physical activity (Correa, Ingraham et al., submitted 2013). Whether these central effects of estrogens account for fatigue (and weight gain) side effects experienced after SERM therapy remains unclear. Nonetheless, these real or perceived side effects of SERMs likely contribute to non-compliance of these hormone therapies in the breast cancer disease. Here, we wish to address this issue directly by comparing how SERMs and estradiol stimulate estrogen-responsive neurons. The concept for this study is guided by our preliminary work showing that estrogen directly activates two discrete neuronal clusters in both pre- and post-menopausal mice. We have exploited the newly developed Riobsome Capture Profiling technique (developed by Knight et al, 2012) that allows one to capture all transcriptional changes in stimulated neurons. Thus, rather than sifting through all genomic changes after estrogen or SERM therapy, this technology allows one to precisely tag and capture the molecular changes taking place in only those neurons directly affected by hormone therapies. This technology now allows us to ask: 1) Are the same subset of neurons affected by estradiol also activated by commonly prescribed SERMs, 2) Do SERMs and estradiol elicit the same or different molecular responses in hypothalamic neurons, and 3) Does signaling initiated by SERMs require an intact estrogen receptor alpha for activating hypothalamic neurons. Here, we will exploit this new technology to directly compare how SERMs and estradiol stimulate estrogen-responsive neurons in the hypothalamus. Our results could help guide improvements on existing SERMs and would be informative for those women at risk for breast cancer in making the decision to begin preventative hormone therapy.
Digitaria ciliaris Koeler
Creators: name: Jeanmonod, Daniel
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Poaceae
Digitaria
Digitaria ciliaris

description: Digitaria ciliaris (Retz.) Koeler
− Bonifacio: bord d’un chemin public au nord du golf de Sperone, localisé, 1.9.201 2, Tison, J.-M. s.n. (Hb. privé, G).
Xénophyte nouvelle pour la Corse, d’origine pantropicale, proche de D. sanguinalis (L.) Scop. dont elle diffère par ses lemmes à nervures latérales pratiquement dépourvues de spicules pectiniformes et par la glume supérieure dépassant généralement la moitié de l’épillet. En outre, les feuilles sont proportionnellement étroites et glabres à la face supérieure, mais il faut se méfier de ces caractères dans le sud de la Corse où on peut les retrouver, associés ou non, chez certaines des nombreuses variations de D. sanguinalis. La présence de franges internervurales sur les lemmes, longtemps considérée à tort comme caractéristique de D. ciliaris, est en fait possible et inconstante chez les deux espèces (WILHALM, Willdenowia 39: 247-259, 2009). Digitaria ciliaris est bien implanté en Espagne et en Italie, mais n’est connu en France que par une récolte ancienne à Avignon et il n’en existait aucune mention en Corse (WILHALM, loc. cit.). Une sous-observation par confusion avec D. sanguinalis est certaine. Rappelons aussi qu’une troisième espèce de ce groupe, D. radicosa (J. Presl) Miq., à glume supérieure plus courte et à rachis des épis lisses, a été trouvée en Corse (Sainte-Lucie-de-Porto-Vecchio, 1969, Coûteaux: cf. VERLOOVE, Candollea 63: 227-233, 2008). Il convient donc d’examiner attentivement les digitaires corses ressemblant à D. sanguinalis, même si l’omniprésence et le polymorphisme de ce dernier aux étages inférieurs de l’île sont parfois décourageants (J.-M. Tison obs. pers., 2011-2012).
description: Published as part of Jeanmonod, Daniel, 2015, Notes à la flore de Corse, XXV, pp. 109-140 in Candollea 70 (1) on page 120, DOI: 10.15553/c2015v701a10, http://zenodo.org/record/5720895
Sunday Chronicle (Paterson, NJ) Vol. 28, No. 9, February 26, 1956
Creators: name: Parrillo, Vincent N.
Publisher: name: The Chronicle Company
Year: 1956

description: Local information pertaining to Paterson, N.J. and surrounding Passaic County. Issues may include events, government, business, political cartoons, engagement and marriage announcements, and birth announcements.  Originally a weekly newspaper, The Sunday Chronicle suspended publication in 1942 because of a manpower and paper shortage, and then began publication again in 1951 as a weekly magazine until 1965.  This publication was also known as the Paterson Chronicle (1952) and the Paterson Sunday Chronicle (1951-1952).  It was North Jersey’s only weekly magazine in its time,  and the first New Jersey publication to carry weekly television listings.
Sphenopsis piurae
Creators: name: Halley, Matthew R.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Thraupidae
Sphenopsis
Sphenopsis piurae

description: Sphenopsis piurae (Chapman) Piura Hemispingus
(Fig. 6)
Hemispingus castaneicollis von Berlepsch 1912: 1094 (in part).
Hemispingus piurae Chapman, 1923, Hilty 2011: 167.
Holotype: AMNH 174541, Palambla, Piura, Peru (see LeCroy 2012: 69). Hemispingus castaneicollis chapmani Sztolcman & Domaniewski, 1927.
3 Spelling corrected in ‘Errata et Emendanda’ slip (see introduction).
4 The registration number of this specimen was mis-transcribed in Warren & Harrison (1971) and has now been corrected in the NHMUK digital catalogue (A. L. Bond in litt. 2022).
Holotype: lost, formerly in the Museum and Institute of Zoology of the Polish Academy of Sciences, Warsaw (MIZ): Tambillo, Cajamarca, Peru (see Mlíkovský 2009: 154).
Hemispingus melanotis piurae Hellmayr 1936: 427, Zimmer 1947: 17, Isler & Isler 1987: 78.
Hemispingus melanotis macrophrys Koepcke, 1961: 22, Isler & Isler 1987: 78.
Holotype: UNMSM 0630, in Museo de Historia Natural ‘ Javier Prado’, Lima: Sunchubamba, Otuzco, La Libertad Department, Peru (see Plenge 1979: 7).
SPECIMENS EXAMINED: (four males, one female): Peru: Piura: Palambla (male: ANSP 116350, 116353, 116354, 116357; female: ANSP 116352).
COMMENTS: As explained above, I consider the morphological and molecular data reviewed here to be sufficient to alleviate concerns of data deficiency that arose during debate of SACC Proposal 284 (Remsen 2007), bolstering the case for recognizing S. piurae at species rank.
description: Published as part of Halley, Matthew R., 2022, Taxonomic status of the Western Hemispingus Sphenopsis ochracea (Thraupidae) and a review of species limits in the genus Sphenopsis P. L. Sclater, 1861, pp. 209-223 in Bulletin of the British Ornithologists' Club 142 (2) on pages 222-223, DOI: 10.25226/bboc.v142i2.2022.a5, http://zenodo.org/record/12535806
Sunday Chronicle (Paterson, NJ) Vol. 28, No. 8, February 19, 1956
Creators: name: Parrillo, Vincent N.
Publisher: name: The Chronicle Company
Year: 1956

description: Local information pertaining to Paterson, N.J. and surrounding Passaic County. Issues may include events, government, business, political cartoons, engagement and marriage announcements, and birth announcements.  Originally a weekly newspaper, The Sunday Chronicle suspended publication in 1942 because of a manpower and paper shortage, and then began publication again in 1951 as a weekly magazine until 1965.  This publication was also known as the Paterson Chronicle (1952) and the Paterson Sunday Chronicle (1951-1952).  It was North Jersey’s only weekly magazine in its time,  and the first New Jersey publication to carry weekly television listings.
Sunday Chronicle (Paterson, NJ) Vol. 28, No. 7, February 12, 1956
Creators: name: Parrillo, Vincent N.
Publisher: name: The Chronicle Company
Year: 1956

description: Local information pertaining to Paterson, N.J. and surrounding Passaic County. Issues may include events, government, business, political cartoons, engagement and marriage announcements, and birth announcements.  Originally a weekly newspaper, The Sunday Chronicle suspended publication in 1942 because of a manpower and paper shortage, and then began publication again in 1951 as a weekly magazine until 1965.  This publication was also known as the Paterson Chronicle (1952) and the Paterson Sunday Chronicle (1951-1952).  It was North Jersey’s only weekly magazine in its time,  and the first New Jersey publication to carry weekly television listings.
Sunday Chronicle (Paterson, NJ) Vol. 28, No. 1, January 1, 1956
Creators: name: Parrillo, Vincent N.
Publisher: name: The Chronicle Company
Year: 1956

description: Local information pertaining to Paterson, N.J. and surrounding Passaic County. Issues may include events, government, business, political cartoons, engagement and marriage announcements, and birth announcements.  Originally a weekly newspaper, The Sunday Chronicle suspended publication in 1942 because of a manpower and paper shortage, and then began publication again in 1951 as a weekly magazine until 1965.  This publication was also known as the Paterson Chronicle (1952) and the Paterson Sunday Chronicle (1951-1952).  It was North Jersey’s only weekly magazine in its time,  and the first New Jersey publication to carry weekly television listings.
Sunday Chronicle (Paterson, NJ) Vol. 27, No. 52, December 25, 1955
Creators: name: Parrillo, Vincent N.
Publisher: name: The Chronicle Company
Year: 1955

description: Local information pertaining to Paterson, N.J. and surrounding Passaic County. Issues may include events, government, business, political cartoons, engagement and marriage announcements, and birth announcements.  Originally a weekly newspaper, The Sunday Chronicle suspended publication in 1942 because of a manpower and paper shortage, and then began publication again in 1951 as a weekly magazine until 1965.  This publication was also known as the Paterson Chronicle (1952) and the Paterson Sunday Chronicle (1951-1952).  It was North Jersey’s only weekly magazine in its time,  and the first New Jersey publication to carry weekly television listings.
Parectopa lithocolletina Zeller 1877
Creators: name: Prins, Jurate De
name: Brito, Rosângela
name: Moreira, Gilson Rudinei Pires
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Gracillariidae
Parectopa
Parectopa lithocolletina

description: Parectopa lithocolletina (Zeller, 1877)
" G.[racilaria] lithocolletina "—Zeller, P.C. 1877. Horae Societatis Entomologicae Rossicae 13(1–4): 415–
416; pl. 6, fig. 147.
Type locality: [Colombia], Chipo.
Type specimens: Holotype ♀, BMNH.
Distribution: Colombia (Zeller 1877: 416).
Larval hostplant(s): Unknown.
description: Published as part of Prins, Jurate De, Brito, Rosângela & Moreira, Gilson Rudinei Pires, 2016, An annotated taxonomic checklist of the Neotropical Gracillariidae (Lepidoptera) with links to the information on host plants and parasitoids, pp. 1-51 in Zootaxa 4158 (1) on page 29, DOI: 10.11646/zootaxa.4158.1.1, http://zenodo.org/record/255480
Lung cancer metastasis during cigarette smoke exposure: a novel role for ceramide/nSMase2 activation
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Smoking-related lung cancer is the leading cause of cancer deaths worldwide. In the U.S., lung cancer is responsible for 29% of cancer deaths, more than those from breast, colon, and prostate cancer combined. Despite exhaustive preclinical- and clinical-studies investigating drivers of metastatic lung cancer, the prognosis of this disease remains very poor with the 5-year survival rate hovering between 5-15%. Thereby, novel mechanistic approaches are highly needed in order to develop effective therapies, particularly against lung cancer spreading/metastasis, which ultimately kills the patients. To address this important problem, the present project includes both in vitro and in vivo studies focused on a novel mechanism(s) underlying the spreading/ metastasis in tobacco smoke-associated lung cancer. Previously we reported that the neutral Sphingomyelinase 2 (nSMase2) enzyme is activated by cigarette smoke (CS)-induced oxidative stress to generate ceramide in airway epithelial cells. We now embark a new paradigm-shift direction in proposing that nSMase2 is a target in lung cancer development and metastasis formation. We hypothesize that lung cancer spreads in the presence of cigarette smoke-induced oxidative stress, via seizing nSMase2 activation. Specifically, the oxidative-stress dependent over-expression and activation of nSMase2 in airway epithelial cells (which follows chronic exposure to tobacco smoke) leads to Sphingosine kinase 1 (Sphk1) over-expression and activation, thereby up-regulating Sphingosine-1 phosphate (S1P) generation; S1P is then secreted, and mediates epithelial reprogramming toward a “mesenchymal” phenotype (EMT), and thus it prompts resistance to oxidative-stress induced apoptosis while enhancing metastasis formation. Our specific aims are: Aim 1. Test the hypothesis that nSMase2 plays a role in reprogramming of airway epithelial cells through cell adaptation to elevated ceramide generation, thereby inducing an apoptosis-resistant phenotype with elevated migratory capacity. Aim 2. Test the hypothesis that nSMase2 controls lung cancer metastasis (in vivo) via instigating the S1P signaling (in a mouse model of lung cancer metastasis). Notably, this project entirely differs from the PI’s previous research goals (and funding) in that it includes: 1) Molecular mechanism(s) of EMT; 2) Studies of lung cancer metastasis; 3) Studies on adaptation to stress and the role of S1P generation by Sphk1.
Oxidative stress and HCV therapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Hepatitis C virus (HCV) is a major etiologic agent of hepatocellular carcinoma (HCC). Antiviral therapy targeting HCV, therefore, constitutes a key anti-cancer strategy to reduce HCC. Studies indicate that HCV exhibits a high degree of genetic variability which complicates antiviral therapy. HCV variants that reduce susceptibility to antivirals can be found even before treatment begins. Baseline polymorphisms can affect the emergence of resistance variants and clinical outcome, and these concerns have largely precluded HCV protease inhibitor as well as NS5A inhibitor mono- therapy, necessitating multiple drug combinations to combat drug resistance. In this regard, recent findings from this laboratory suggest a potential alternate method to reduce the antiviral resistance of HCV. HCV directly induces oxidative stress in hepatocytes. Glutathione (GSH), an endogenous antioxidant, is significantly depleted in hepatitis C patients. In addition, alcohol consumption decreases the efficacy of interferon alpha therapy, and alcohol has been associated with increased sequence heterogeneity of HCV RNA. Preliminary study indicated that ethanol and L-buthionine -S,R-sulfoximine (BSO), which decreased GSH level as seen in hepatitis C patients, elevated both nucleotide and amino acid substitution rates of genotype 1b HCV RNA in cell culture. The dn/ds ratio and percentage of sites undergoing positive selection also increased, resulting in increased detection of NS5A sequence variants implicated in resistance to antivirals such as interferon alpha, ribavirin, cyclosporine, and a new direct-acting antiviral, Daclatasvir, that inhibits NS5A. Moreover, iron chelator and GSH ester treatments reduced these effects. These data suggest that ethanol- and virus-induced redox changes likely contribute to baseline sequence variability of HCV RNA. Data further suggest that, by targeting these processes, it may be possible to decrease the natural polymorphism of HCV and associated drug resistance to improve the therapeutic efficacy of antivirals. Recently, a direct source of the HCV-induced oxidative stress that can be inhibited pharmacologically was identified. Goal of this study, therefore, is to determine whether oxidative stress and strategies that specifically target redox reactions can affect the emergence of drug resistant variants during antiviral treatments and whether these strategies can enhance the efficacy of anti-HCV agents in vitro. We hypothesize that oxidative stress contrib
Digitaria violascens Link
Creators: name: Jeanmonod, Daniel
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Poaceae
Digitaria
Digitaria violascens

description: Digitaria violascens Link
− Canale-di-Verde: ornière détrempée d’un chemin à 350 m à l’ENE du pont de Teghia, 90 m, quelques pieds, 3.9.201 2, Tison, J.-M. s.n. (Hb. privé); Bonifacio: golf de Sperone, abondant, aussi çà et là hors du golf dans les pelouses et les ourlets environnants, 1.9.201 2, Tison, J.-M. s.n. (Hb. Privé, G).
Xénophyte nouvelle pour la Corse, originaire d’Asie tropicale, proche de D. ischaemum (Schweigg.) Mühl. dont elle diffère par ses épillets plus petits, plus serrés, moins rapidement caducs, à poils moins abondants et non crépus ne donnant pas d’aspect «farineux» à faible grossissement. Alors que D. ischaemum est invariablement une petite thérophyte d’été aux tiges souples et graciles, D. violascens est globalement plus robuste et surtout extrêmement variable selon le biotope. Bien que sa morphologie habituelle en Corse soit, comme en France continentale, celle d’une thérophyte aux tiges étalées et rigides de 10-25 cm, certains exemplaires bonifaciens sont fortement radicants aux noeuds et peut-être pérennants; ceux situés à l’ombre développent parfois des tiges ascendantes pouvant atteindre 60 cm, à feuilles de 8-12 cm, commençant ainsi à ressembler aux populations tropicales. L’espèce a été récemment identifiée en Europe, notamment dans le Midi de la France et en Lombardie (JAUZEIN, Monde Pl. 443: 28-30, 1992, sub D. longiflora (Retz.) Pers.; VERLOOVE, Candollea 63: 227-233, 2008). Elle infeste notoirement les gazons artificiels régulièrement tondus, sans qu’on sache exactement si c’est un polluant des semences ou une xénophyte d’origine différente réussissant particulièrement bien dans ce biotope (VERLOOVE, loc. cit.). Le cas de Bonifacio, où elle se distribue sur l’ensemble du green alors qu’elle n’existe pas, par exemple, dans les plates-bandes de l’agglomération, est en faveur de la première hypothèse.
description: Published as part of Jeanmonod, Daniel, 2015, Notes à la flore de Corse, XXV, pp. 109-140 in Candollea 70 (1) on page 120, DOI: 10.15553/c2015v701a10, http://zenodo.org/record/5720895
Parectopa lithomacha Meyrick 1915, n. sp.
Creators: name: Prins, Jurate De
name: Brito, Rosângela
name: Moreira, Gilson Rudinei Pires
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Gracillariidae
Parectopa
Parectopa lithomacha

description: Parectopa lithomacha Meyrick, 1915
" Parectopa lithomacha, n. sp. "—Meyrick, E. 1915b. Transactions of the Entomological Society of London
(2): 235–236.
Type locality: Ecuador, Huigra, 4500 ft.
Type specimens: 24 syntypes (♂ and ♀), BMNH. Distribution: Ecuador (Meyrick 1915b: 236).
Larval hostplant(s): Unknown.
description: Published as part of Prins, Jurate De, Brito, Rosângela & Moreira, Gilson Rudinei Pires, 2016, An annotated taxonomic checklist of the Neotropical Gracillariidae (Lepidoptera) with links to the information on host plants and parasitoids, pp. 1-51 in Zootaxa 4158 (1) on page 29, DOI: 10.11646/zootaxa.4158.1.1, http://zenodo.org/record/255480
USING STRUCTURAL EQUATION MODELING: THE IMPACT OF FACTORS INFLUENCING ON DIGITAL BANKING ADOPTION IN INDIA THROUGH FINTECH APPLICATIONS - A CASE STUDY OF RANGA REDDY DISTRICT OF TELANGANA STATE
Creators: name: V. BHAVANI
Publisher: name: Zenodo
Year: 2024
Subjects: Digital Banking, Customers Perception, Awareness, SEM Model.

description: Abstract

Purpose: Appropriate research instruments were used to conduct the current investigation. With the aid of 200 Axis Bank customers' replies, we were able to conduct research and provide some recommendations. Although digital banking is quick and easy, it has a number of security flaws. For the protection of their clients when they conduct a variety of financial activities online, banking institutions have implemented a number of security measures. Design/Methodology/Approach: The goal of this study is to identify the issues that consumers encounter while using digital banking services and to assess their level of knowledge and understanding about digital banking security. I selected the sample size of 200 customers of Axis bank Hyderabad of Telangana state. Stratified random sampling technique is used through Structure Questionnaire. Originality/Value: In order to determine the internal consistency, or the degree to which a collection of items are connected, this research makes use of reliability tests such as Cronbach's alpha test. As a measure of the dependability of the scale, it is widely used. A "high" alpha value does not always indicate that the metric is one-dimensional and one way to assess dimensionality and Structure Equation Modelling is via exploratory factor analysis. Findings: Findings from studies on digital banking contributed to the development of a precautionary checklist for various problems that can arise in this age of digital banking. Moreover, for the purpose of enhancing the security of digital banking systems, there should be a strong and comprehensive security policy implemented by banks and laws passed by regional or state governments.
Sunday Chronicle (Paterson, NJ) Vol. 27, No. 51, December 18, 1955
Creators: name: Parrillo, Vincent N.
Publisher: name: The Chronicle Company
Year: 1955

description: Local information pertaining to Paterson, N.J. and surrounding Passaic County. Issues may include events, government, business, political cartoons, engagement and marriage announcements, and birth announcements.  Originally a weekly newspaper, The Sunday Chronicle suspended publication in 1942 because of a manpower and paper shortage, and then began publication again in 1951 as a weekly magazine until 1965.  This publication was also known as the Paterson Chronicle (1952) and the Paterson Sunday Chronicle (1951-1952).  It was North Jersey’s only weekly magazine in its time,  and the first New Jersey publication to carry weekly television listings.
Engineered biosynthesis of antimycin-type anticancer drugs
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: High levels of antiapoptotic Bcl2 family members are associated with resistance of many tumors to chemotherapy and radiation therapy, offering an attractive but challenging target for the development of anticancer agents. The antimycin family of natural products has enormous potential as small-molecule Bcl2/BclXL inhibitors because they are structurally and mechanistically unique. To further develop antimycin-type anticancer agents with enhanced potency and selectivity, efficient routes for antimycin production and derivatization are required. The difficulties associated with synthetic manipulations of structurally complex antimycins have precluded facile analoging of these compounds. Engineered biosynthesis of antimycin analogs thus represents an attractive option to accelerate the development of antimycin compounds exhibiting improved anticancer properties. The research proposed here is directed toward understanding how Nature makes antimycins and how we can harness that understanding to produce new bioactive antimycin-type compounds. This work will provide insights into the biosynthesis of an unusual family of secondary metabolites, and may ultimately lead to the development of new anticancer agents suitable for use in humans. Our objectives and methods are: Objective 1: Elucidate the enzymatic logic of dilactone scaffold modification in antimycin biosynthesis. One post-assembly modification step: a transesterification reaction to yield a C-8 acyloxy, remains to be elucidated in order to generate the fully modified antimycin dilactone ring. We propose that an acyltransferase homolog (AntB) catalyzes this transesterification reaction. We will verify the role of AntB in antimycin biosynthesis by both in vivo targeted gene disruption experiment followed by analysis of biosynthetic intermediates, and in vitro biochemical analysis using purified enzymes and proposed substrates. Objective 2: Biosynthesize antimycin analogs with enhanced anticancer potency and selectivity. Structural variations have been observed for the C-8 acyl moiety of antimycins, indicating the substrate promiscuity of the tailoring enzymatic machinery. The substrate specificity of AntB toward both acyl groups and acyl carriers will be examined in detail. We will then expand the biosynthetic potential using rational and combinatorial approaches.
USING STRUCTURAL EQUATION MODELING: THE IMPACT OF FACTORS INFLUENCING ON DIGITAL BANKING ADOPTION IN INDIA THROUGH FINTECH APPLICATIONS - A CASE STUDY OF RANGA REDDY DISTRICT OF TELANGANA STATE
Creators: name: V. BHAVANI
Publisher: name: Zenodo
Year: 2023
Subjects: Digital Banking, Customers Perception, Awareness, SEM Model.

description: Abstract

Purpose: Appropriate research instruments were used to conduct the current investigation. With the aid of 200 Axis Bank customers' replies, we were able to conduct research and provide some recommendations. Although digital banking is quick and easy, it has a number of security flaws. For the protection of their clients when they conduct a variety of financial activities online, banking institutions have implemented a number of security measures. Design/Methodology/Approach: The goal of this study is to identify the issues that consumers encounter while using digital banking services and to assess their level of knowledge and understanding about digital banking security. I selected the sample size of 200 customers of Axis bank Hyderabad of Telangana state. Stratified random sampling technique is used through Structure Questionnaire. Originality/Value: In order to determine the internal consistency, or the degree to which a collection of items are connected, this research makes use of reliability tests such as Cronbach's alpha test. As a measure of the dependability of the scale, it is widely used. A "high" alpha value does not always indicate that the metric is one-dimensional and one way to assess dimensionality and Structure Equation Modelling is via exploratory factor analysis. Findings: Findings from studies on digital banking contributed to the development of a precautionary checklist for various problems that can arise in this age of digital banking. Moreover, for the purpose of enhancing the security of digital banking systems, there should be a strong and comprehensive security policy implemented by banks and laws passed by regional or state governments.
Nanoparticle capsules for combined release and hyperthermia
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: We propose to develop and test a potential new therapeutic system for tumor treatment using novel nanoparticle-based capsules recently developed in our lab. The capsules are hollow gold shells formed from closely packed nanoparticles. These capsules can be non-invasively optically triggered to release their contents while simultaneously heating their local environment (hyperthermia therapy). We recently developed a new mechanism to generate the nanoparticle-based microcapsules using gold NPs, assembled using liquid crystal ligands. The method is generalizable to different NP types and we have most recently produced gold-based capsules from 10nm particles. In this project we will develop this capsule technology for use as a multifunctional cancer therapy. The three key functions of the capsule, loading, triggered release and localized heating have been demonstrated in preliminary data. We aim to develop this novel capsule technology for applications in cancer nano-medicine using spherical and rod-like gold particles (for infra-red stimulation compatible with existing technologies) and outline a plan to test the capsules for triggered release and simultaneous local hyperthermia both in-vitro and in cells.
Sunday Chronicle (Paterson, NJ) Vol. 27, No. 4, January 23, 1955
Creators: name: Parrillo, Vincent S.
Publisher: name: The Chronicle Company
Year: 1955

description: Local information pertaining to Paterson, N.J. and surrounding Passaic County. Issues may include events, government, business, political cartoons, engagement and marriage announcements, and birth announcements. Originally a weekly newspaper, The Sunday Chronicle suspended publication in 1942 because of a manpower and paper shortage, and then began publication again in 1951 as a weekly magazine until 1965. This publication was also known as the Paterson Chronicle (1952) and the Paterson Sunday Chronicle (1951-1952). It was North Jersey’s only weekly magazine in its time, and the first New Jersey publication to carry weekly television listings.
Molecular basis of the switch between cell arrest and cell death in the p53 protein family
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: How cells choose between cell arrest and apoptosis pathways remains a fundamental biological question. In the case of the p53 protein family, its three transcription factors - p73, p63 and p53 - each triggers a gene expression pattern that leads to specific cellular pathways. At the same time, these transcription factors recognize the same consensus response element sequences and their transactivation of target genes overlaps. After we have solved the first crystal structures of the DNA-binding domain of p73 in complex with full-site response elements that conform to the ideal consensus site, we have developed a preliminary molecular explanation of how p73 conformation switches to distinguish between cell arrest/DNA repair targets and apoptotic targets. In our model Lys138 leads to a tetramer unable to trigger activation when guanines are present in the response element, potentially awaiting for acetylation for its activation. Having mastered the conditions of crystallization, we propose to confirm the validity of this model by solving the structure of p73 DNA-binding domain in complex with response elements that trigger the activation of either cell arrest or apoptotic targets by X-ray crystallography.
Sunday Chronicle (Paterson, NJ) Vol. 27, No. 3, January 16, 1955
Creators: name: Parrillo, Vincent S.
Publisher: name: The Chronicle Company
Year: 1955

description: Local information pertaining to Paterson, N.J. and surrounding Passaic County. Issues may include events, government, business, political cartoons, engagement and marriage announcements, and birth announcements. Originally a weekly newspaper, The Sunday Chronicle suspended publication in 1942 because of a manpower and paper shortage, and then began publication again in 1951 as a weekly magazine until 1965. This publication was also known as the Paterson Chronicle (1952) and the Paterson Sunday Chronicle (1951-1952). It was North Jersey’s only weekly magazine in its time, and the first New Jersey publication to carry weekly television listings.
Development of a general synthesis of the lissoclimides and haterumaimides, potent antitumor agents, and evaluation of their activities against solid tumors and aggressive cancer cell lines
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The family of labdane diterpenoid alkaloids consisting of the lissoclimides and haterumaimides includes potent cytotoxins, some of which demonstrate sub-nanomolar cytotoxicity against P388 murine leukemia cells and low nanomolar activity against human carcinoma KB cells. No members of this group of about 20 alkaloids has succumbed to chemical synthesis and, as a result, only a few analogs have been made from scarce natural materials. We propose an efficient and general approach to this family of cytotoxins that will avail our collaborators with sufficient material for in depth biochemical evaluation; furthermore, the plan that we put forth will enable access to analogs only available by chemical synthesis including, but not limited to, stereoisomers of the natural products. Our approach involves a stereocontrolled cation-pi bicyclization to set up the trans-decalin core of the natural products with appropriate functional group arrangements to maximize access to multiple members of the family. While the research proposed under the auspices of a CRCC grant will largely focus on the development of the general approach in the context of haterumaimide Q—one of the less functionalized members of the family—differential A-ring halogenation and B-ring oxidation will ultimately be achievable by manipulation of cyclic alkene and allylsilane intermediates, respectively. Auxiliary-mediated diastereoselective aldol addition reactions will be used to access different stereoisomers of the salient beta-hydroxyimide functionality that has previously been shown to be critical to activity. Long-term goals, ideally accomplished with funds from an eventual federal grant, will include the synthesis of dozens of different lissoclimides and haterumaimide natural products and analogs. All late-stage intermediates, natural products, and analogs will be provided to our collaborators for evaluation of cytotoxicity against aggressive human tumor cell lines and solid tumors. Any leads will be followed up with mechanism of action studies as well as other pertinent pre-clinical investigations, as the data warrants.
Parectopa nesitis Walsingham 1897, sp. n.
Creators: name: Prins, Jurate De
name: Brito, Rosângela
name: Moreira, Gilson Rudinei Pires
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Gracillariidae
Parectopa
Parectopa nesitis

description: Parectopa nesitis (Walsingham, 1897)
" Gracilaria nesitis, sp. n. "—Walsingham, Lord (Thomas de Grey). 1897. Proceedings of the Zoological
Society of London 1897(10): 153.
Type locality: [Virgin Islands], S[ain]t Thomas.
Type specimens: Type ♀, coll. Gudmann, 1 more specimen [not included in type series]. Note: Microlepidoptera specimens of Gudmann collection in 1932 were obtained by C.S. Larsen (Faaborg,
Denmark) (Horn & Kahle 1935: 98).
Distribution: Virgin Islands: Saint Thomas (Walsingham 1897: 153). Larval hostplant(s): Unknown.
description: Published as part of Prins, Jurate De, Brito, Rosângela & Moreira, Gilson Rudinei Pires, 2016, An annotated taxonomic checklist of the Neotropical Gracillariidae (Lepidoptera) with links to the information on host plants and parasitoids, pp. 1-51 in Zootaxa 4158 (1) on page 29, DOI: 10.11646/zootaxa.4158.1.1, http://zenodo.org/record/255480
Open space and recreation including a survey of existing facilities, an analysis of needs and a proposed long range park plan for Cumberland County, New Jersey
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1966

description: This report presents a complete inventory and analysis of all existing open space and recreation facilities. From this survey of 1966 conditions and needs the basic future requirements for county open space have been drawn.  In addition to the inventory, the report also includes: a general introduction; open space and recreation standards; a needs analysis; and the proposed county open space and recreation plan.