cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Structural stability of antimicrobial peptides rich in tryptophan, proline and arginine: a computational study
Creators: name: Marimuthu, Sathish Kumar
name: Nagarajan, Krishnanand
name: Perumal, Sathish Kumar
name: Palanisamy, Selvamani
name: Subbiah, Latha
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: The host defense peptides or antimicrobial peptides (AMPs) often contain short sequence of amino acids, either positive or negatively charged and express broad-spectrum antibacterial, antiviral and antifungal activity. Many researchers had reported that tryptophan, arginine and proline rich AMPs have a promising source of next-generation antibiotics. Nowadays, AMPs are used as a possible therapeutic source for future antibiotics. In the present study, the amino acid sequences of 2924 AMPs belonging to various sources rich in Tryptophan, Proline and Arginine was chosen for investigation. The AMPs were further categorized according to their source, structure and antimicrobial activities. The AMPs with tryptophan, arginine, proline residues in abundance with maximum sequence length of 20 amino acids alone was obtained. Homology modeling was performed with PEP-FOLD and the modeled structures were evaluated using RAMPAGE to identify the structural information. Further, the stability of peptide in aqueous condition was probed using molecular dynamics simulations. Communicated by Ramaswamy H. Sarma
Sonnenfleckenzeichnung Nr. 182.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.08.1975, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
Sonnenfleckenzeichnung Nr. 56.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 17.03.1975, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
Identification of novel human neutrophil elastase inhibitors from dietary phytochemicals using in silico and in vitro studies
Creators: name: Vidhya, Ramachandran
name: Anbumani, Velmurugan Ilavarasi
name: Rao, Ampasala Dinakara
name: Anuradha, Carani Venkatraman
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Hematology

description: Human neutrophil elastase (HNE) has been well studied as a therapeutic target for inflammatory diseases for several decades. A variety of small-molecule HNE inhibitors have been well known, and their mode of binding at the active site of the enzyme has been determined, but none of them reached clinical trials except sivelestat. In this study, we intended to identify potent dietary phytochemicals that can target the active site of HNE by employing computational methods and in vitro inhibition assay. Database retrieval and preparation, structure-based virtual screening and molecular docking, rescoring, free energy calculations, adsorption, distribution, metabolism, and excretion (ADME) predictions and an in vitro assay were conducted to propose a collection of biochemically active molecules with the potential for inhibition against HNE. Overall, 167,504 secondary metabolites originating from the plants were docked. Of these, five natural compounds with drug-like properties have shown remarkable docking profiles to HNE. These hit candidates were then examined for validation through an HNE inhibition assay. The results showed that troxerutin (TX) had better binding efficacy with HNE followed by oleuropein, scutellarin, hesperidin and gossypin. These phytochemicals are present in relatively common fruits and vegetables, indicating the potential for safe and affordable inflammatory disease therapy.HighlightsTroxerutin shows the highest HNE binding affinity in computational analysis.HIS A: 57 is the major contributor to the protein-ligand interaction.Flavonoids exhibit binding efficacy against HNE.Flavonoids may serve as potent inhibitors for HNE. Troxerutin shows the highest HNE binding affinity in computational analysis. HIS A: 57 is the major contributor to the protein-ligand interaction. Flavonoids exhibit binding efficacy against HNE. Flavonoids may serve as potent inhibitors for HNE. Communicated by Ramaswamy H. Sarma
Перспективы использования модернизированного твердомера Ревякина в условиях почвенного канала
Creators: name: Евдокимов Владислав Николаевич
name: Болилый Артем Олегович
Publisher: name: Zenodo
Year: 2024

description: Испытания рабочих органов сельскохозяйственных почвообрабатывающих машин в почвенном канале сопровождаются определением твердости и деформационного показателя почвы. Результаты определения твердости и деформационного показателя почвы необходимы для правильного сопоставления результатов экспериментальных исследований. Цель конструкторской разработки – повысить устойчивость твердомера при проведении измерений, обеспечить запись результатов нескольких измерений на одной бумажной ленте, снизить затраты времени на снятие и установку карандаша. Конструкторская разработка была выполнена сотрудниками отдела механизации производства и разработки новых образцов техники ФГБУН «НИИ СХ Крыма». Твердомер состоит из верхней и нижней опорных пластин, направляющих штанг для подвижной пластины, телескопической штанги со сменным наконечником, пружины, каретки, пишущего механизма, рукоятки и фиксирующего винта. Одна из направляющих штанг снабжена лентопротяжным механизмом, состоящим из направляющего желоба, на концах которого расположены боковые опоры, в отверстиях которых установлены валы с барабанами, при этом на верхнем валу установлена рукоятка, способная двигаться вдоль вала и снабженная двумя винтиками, головки которых входят в ответные отверстия боковой опоры. Рукоятка прижата к опоре малой пружиной. Карандаш установлен в зажиме, жестко закрепленном на откидной пластине, шарнирно соединенной с уголком, жестко соединенным с упругой скобой, установленной на горизонтальной тяге пишущего механизма. Откидная пластина фиксируется в рабочем положении зацеплением круглых выштамповок на откидной пластине и уголке, при этом откидная пластина прижата к уголку пружиной, сжатие которой регулируется гайкой-барашком, установленной на болте. На нижней опорной пластине жестко закреплены кронштейны, к которым двумя болтовыми соединениями прикреплены опорные ноги, конец каждой из которых жестко соединен с пластиной, имеющей резьбовое соединение с круглой опорой.
title: Breast carcinomas: factors influencing appearance on sonoelastography
Creators: name: Fleury, Eduardo
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Breast
subject: Breast - Your latest results

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Breast carcinomas are found in around 20% of ultrasound-guided percutaneous breast biopsies (1,2). These carcinomas tend to have typical malignancy features with a high positive predictive value, such as irregular margins which yield a positive...
title: New Methods of Computer Aided Optimization of Investment and Operating Costs for Buildings During Their Useful Life
Creators: name: Brennig, Thomas
name: Sanio, Hans-Peter
Publisher: name: Bauhaus-Universität Weimar
Year: 2004
Subjects: subject: Optimierung
subject: Baukosten
subject: Betriebskosten
subject: 620

description: Current software solutions for real estate planning, construction and use, do not model the complete life cycle of a building. Well-integrated software tools exist for the planning and construction phases. Data integrity exists throughout the planning and construction phases, but problems occur at the transition to the use-phase. At this interface, the complete data set of planning and execution gets lost. Another software deficiency is that current software solutions don’t handle construction work and maintenance work equally. This is why a new software generation is demanded, which continuously covers the entire workflow process from the planning phase to the demolition of a building. New data concepts have to be developed, which allow bringing work items for construction together with work items for real estate use.
description: X. International Conference on Computing in Civil and Building Engineering: proceedings ; [ICCCBE], Weimar, June 02-04, 2004, vol. 2004
title: Utility of breast MRI for the evaluation of patients with metastatic axillary lymph node and initially negative mammography and sonography
Creators: name: Alonso Bartolomé, Pilar
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Breast
subject: Breast

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: To evaluate the ability of breast MR imaging in the identification of primary malignancies in patients with axillary lymph node metastases and initially negative mammography and...
Sonnenfleckenzeichnung Nr. 85.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 23.04.1975, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
Sonnenfleckenzeichnung Nr. 124.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 08.06.1975, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
Synthetic flavonoids as potential antiviral agents against SARS-CoV-2 main protease
Creators: name: Batool, Farwa
name: Mughal, Ehsan Ullah
name: Zia, Komal
name: Sadiq, Amina
name: Naeem, Nafeesa
name: Javid, Asif
name: Ul-Haq, Zaheer
name: Saeed, Muhammad
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: The COVID-19 pandemic has claimed more than a million lives worldwide within a short time span. Due to the unavailability of specific antiviral drugs or vaccine, the infections are causing panic both in general public and among healthcare providers. Therefore, an urgent discovery and development of effective antiviral drug for the treatment of COVID-19 is highly desired. Targeting the main protease (Mpro) of the causative agent, SARS-CoV-2 has great potential for drug discovery and drug repurposing efforts. Published crystal structures of SARS-CoV-2 Mpro further facilitated in silico investigations for discovering new inhibitors against Mpro. The present study aimed to screen several libraries of synthetic flavonoids and benzisothiazolinones as potential SARS-CoV-2 Mpro inhibitors using in silico methods. The short-listed compounds after virtual screening were filtered through SwissADME modeling tool to remove molecules with unfavorable pharmacokinetics and medicinal properties. The drug-like molecules were further subjected to iterative docking for the identification of top binders of SARS-CoV-2 Mpro. Finally, molecular dynamic (MD) simulations and binding free energy calculations were performed for the evaluation of the dynamic behavior, stability of protein–ligand complex, and binding affinity, resulting in the identification of thioflavonol, TF-9 as a potential inhibitor of Mpro. The computational studies further revealed the binding of TF-9 close to catalytic dyad and interactions with conserved residues in the S1 subsite of the substrate binding site. Our in-silico study demonstrated that synthetic analogs of flavonoids, particularly thioflavonols, have a strong tendency to inhibit the main protease Mpro, and thereby inhibit the reproduction of SARS-CoV-2. Communicated by Ramaswamy H. Sarma
title: Quantitative measurement of inspiratory capacity by Xenon ventilation imaging using dual energy CT
Creators: name: Leung, Kit Yee
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Lung
subject: CT
subject: Computer Applications-Detection, diagnosis

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Xenon (Xe) ventilation imaging using dual energy CT is capable to depict regional lung ventilation function. However, it cannot be applied for patient follow-up evaluation because it is not a truly quantitative measurement. In this study, we...
Miniaria richarti Shear & Marek 2023
Creators: name: Shear, William A.
name: Marek, Paul E.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Chordeumatida
Striariidae
Miniaria
Miniaria richarti

description: Miniaria richarti Shear & Marek, 2023
Miniaria richarti Shear & Marek, 2023, Zootaxa 5264: 328. Male holotype and female paratype from Rainier Road, 3 miles northwest of Military Road, Fort Lewis Military Reservation, Thurston Co., Washington (CAS). Known from localities in Thurston, Cowlitz, Mason and Wahakiakum Cos., Washington, and from Tillamook Co., Oregon.
description: Published as part of Shear, William A. & Marek, Paul E., 2024, The millipede family Striariidae Bollman, 1893. IX. The identity of Striaria californica Cook, 1899, and the new genus Bayaria for Striaria nana Loomis, 1936, with a key to genera and an annotated checklist of the Striariidae (Diplopoda, Chordeumatida, Striarioidea), pp. 524-544 in Zootaxa 5463 (4) on page 538, DOI: 10.11646/zootaxa.5463.4.4, http://zenodo.org/record/11612167
Sonnenfleckenzeichnung Nr. 255.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.11.1975, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
title: Significance of prominent hypointense signals on susceptibility-weighted images (SWI) in the draining veins within and adjacent areas of cerebral infarction
Creators: name: Choo, Ka Yeon
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Neuroradiology brain
subject: Ischaemia / Infarction
subject: Neuro - Stroke

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: ...
Sonnenfleckenzeichnung Nr. 144.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.06.1975, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
title: 23 Things Physical Samples
Creators: name: Plomp, Esther
name: Ramdeen, Sarah
name: Klump, Jens
name: Wyborn, Lesley
name: Edrington, Clint
name: Donaldson, Mary
name: Damerow, Joan
name: Islam, Sharif
Publisher: name: Research Data Alliance
Year: 2021

description: An adapted version of the RDA "23 Things: Libraries for Research Data" output for Physical Samples.
Structure-based identification of potential SARS-CoV-2 main protease inhibitors
Creators: name: Khan, Shama
name: Fakhar, Zeynab
name: Hussain, Afzal
name: Ahmad, Aijaz
name: Jairajpuri, Deeba Shamim
name: Alajmi, Mohamed F.
name: Hassan, Md. Imtaiyaz
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: To address coronavirus disease (COVID-19), currently, no effective drug or vaccine is available. In this regard, molecular modeling approaches are highly useful to discover potential inhibitors of the main protease (Mpro) enzyme of SARS-CoV-2. Since, the Mpro enzyme plays key roles in mediating viral replication and transcription; therefore, it is considered as an attractive drug target to control SARS-CoV-2 infection. By using structure-based drug design, pharmacophore modeling, and virtual high throughput drug screening combined with docking and all-atom molecular dynamics simulation approach, we have identified five potential inhibitors of SARS-CoV-2 Mpro. MD simulation studies revealed that compound 54035018 binds to the Mpro with high affinity (ΔGbind −37.40 kcal/mol), and the complex is more stable in comparison with other protein-ligand complexes. We have identified promising leads to fight COVID-19 infection as these compounds fulfill all drug-likeness properties. However, experimental and clinical validations are required for COVID-19 therapy. Communicated by Ramaswamy H. Sarma
title: Time is brain, but each patient has his own time
Creators: name: Gonzalez, Ramon
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Neuroradiology brain
subject: Ischaemia / Infarction
subject: Neuro - Stroke

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: “Time is brain” is the guiding principle in the management of acute ischemic stroke, and is a major reason for the current state of affairs that limits neuroimaging to simple noncontrast head CT scans in patients being considered for stroke...
Petra sierwaldae Shear, Marek, Bond & Wesener 2022
Creators: name: Shear, William A.
name: Marek, Paul E.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Chordeumatida
Striariidae
Petra
Petra sierwaldae

description: Petra sierwaldae Shear, Marek, Bond & Wesener, 2022, Zootaxa 5213: 288.
Male holotype and male and female paratypes from Beauty Creek, Panhandle National Forest, Kootenai Co., Idaho (FMNH).
Known from three localities along Beauty and Bumblebee Creeks, Kootenai Co., Idaho.
description: Published as part of Shear, William A. & Marek, Paul E., 2024, The millipede family Striariidae Bollman, 1893. IX. The identity of Striaria californica Cook, 1899, and the new genus Bayaria for Striaria nana Loomis, 1936, with a key to genera and an annotated checklist of the Striariidae (Diplopoda, Chordeumatida, Striarioidea), pp. 524-544 in Zootaxa 5463 (4) on page 538, DOI: 10.11646/zootaxa.5463.4.4, http://zenodo.org/record/11612167
title: Thrombus hounsfield unit on CT predicts vascular recanalization in stroke patients
Creators: name: Fernàndez-Termes, Helena
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Neuroradiology brain
subject: Ischaemia / Infarction
subject: Neuro - Stroke

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Early vascular recanalization is essential for the successful treatment of acute stroke. Computed tomography (CT) can detect thrombi in arteries after acute stroke, and can provide a measure composition based on Hounsfield Units (HU). According to...
Sonnenfleckenzeichnung Nr. 30.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.02.1975, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
Sonnenfleckenzeichnung Nr. 73.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.04.1975, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
Sonnenfleckenzeichnung Nr. 23.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 01.02.1975, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
Identification of novel human neutrophil elastase inhibitors from dietary phytochemicals using in silico and in vitro studies
Creators: name: Vidhya, Ramachandran
name: Anbumani, Velmurugan Ilavarasi
name: Rao, Ampasala Dinakara
name: Anuradha, Carani Venkatraman
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Hematology

description: Human neutrophil elastase (HNE) has been well studied as a therapeutic target for inflammatory diseases for several decades. A variety of small-molecule HNE inhibitors have been well known, and their mode of binding at the active site of the enzyme has been determined, but none of them reached clinical trials except sivelestat. In this study, we intended to identify potent dietary phytochemicals that can target the active site of HNE by employing computational methods and in vitro inhibition assay. Database retrieval and preparation, structure-based virtual screening and molecular docking, rescoring, free energy calculations, adsorption, distribution, metabolism, and excretion (ADME) predictions and an in vitro assay were conducted to propose a collection of biochemically active molecules with the potential for inhibition against HNE. Overall, 167,504 secondary metabolites originating from the plants were docked. Of these, five natural compounds with drug-like properties have shown remarkable docking profiles to HNE. These hit candidates were then examined for validation through an HNE inhibition assay. The results showed that troxerutin (TX) had better binding efficacy with HNE followed by oleuropein, scutellarin, hesperidin and gossypin. These phytochemicals are present in relatively common fruits and vegetables, indicating the potential for safe and affordable inflammatory disease therapy.
HighlightsTroxerutin shows the highest HNE binding affinity in computational analysis.HIS A: 57 is the major contributor to the protein-ligand interaction.Flavonoids exhibit binding efficacy against HNE.Flavonoids may serve as potent inhibitors for HNE. Troxerutin shows the highest HNE binding affinity in computational analysis. HIS A: 57 is the major contributor to the protein-ligand interaction. Flavonoids exhibit binding efficacy against HNE. Flavonoids may serve as potent inhibitors for HNE. Communicated by Ramaswamy H. Sarma
Sonnenfleckenzeichnung Nr. 118.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.06.1975, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
title: New distant tumors in patients successfully treated for glioblastoma multiformis: 10 years experience
Creators: name: Tartaglione, Tommaso
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Neuroradiology brain
subject: Neuroradiology peripheral nerve
subject: Neuroradiology spine
subject: Oncology
subject: Neoplasia
subject: Neuro - Tumor

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: The term Glioblastoma Multiforme (GBM) was coined at the beginning of the last century (1) , and refers to a morphologically highly heterogeneous neoplasm, with microvascular proliferation and/or necrosis (WHO grade IV) (2) . Two distinct...
Plaramia Shear & Marek 2022
Creators: name: Shear, William A.
name: Marek, Paul E.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Chordeumatida
Striariidae
Plaramia

description: Genus Plaramia Shear & Marek, 2022
Plaramia Shear & Marek, 2022b, Zootaxa 5205: 519.
Type species, Plaramia arcata Shear & Marek, 2022, by original designation. Two species.
description: Published as part of Shear, William A. & Marek, Paul E., 2024, The millipede family Striariidae Bollman, 1893. IX. The identity of Striaria californica Cook, 1899, and the new genus Bayaria for Striaria nana Loomis, 1936, with a key to genera and an annotated checklist of the Striariidae (Diplopoda, Chordeumatida, Striarioidea), pp. 524-544 in Zootaxa 5463 (4) on page 538, DOI: 10.11646/zootaxa.5463.4.4, http://zenodo.org/record/11612167
title: Characterization of T2 hypointense lesions within pediatric diffuse intrinsic pontine glioma using susceptibility-weighted, diffusion-weighted, dynamic susceptibility-weighted contrast-enhanced perfusion and conventional MR imaging
Creators: name: Löbel, Ulrike
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Neuroradiology brain
subject: Neuroradiology peripheral nerve
subject: Neuroradiology spine
subject: Oncology
subject: Neoplasia
subject: Neuro - Tumor

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References
description: Learning objectives: This exhibit will illustrate and discuss the conventional magnetic resonance imaging (MRI) appearance and significance of T2 hypointense foci in diffuse intrinsic pontine gliomas . We will describe how the following advanced MRI techniques can aid...
title: Enhancing fraction (EnF) in glioblastoma multiforme (GBM): A comparison of contrast agent concentration and signal intensity based methods of measurement
Creators: name: Mills, Samantha
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Neuroradiology brain
subject: Neuroradiology peripheral nerve
subject: Neuroradiology spine
subject: Oncology
subject: Neoplasia
subject: Neuro - Tumor

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Enhancing fraction (EnF) has recently been identified as providing promising clinical information in glioma [1-3]. The initial area under the concentration time curve ( IAUC 60 ) derived from dynamic contrast enhanced MRI (DCE-MRI) is used to...
Computational gene expression profiling in the exploration of biomarkers, non-coding functional RNAs and drug perturbagens for COVID-19
Creators: name: Aishwarya, S.
name: Gunasekaran, K.
name: Margret, A. Anita
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Computational Biology

description: The coronavirus disease, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a global health crisis that is being endured with an increased alarm of transmission each day. Though the pandemic has activated innumerable research attention to decipher an antidote, fundamental understanding of the molecular mechanisms is necessary to halt the disease progression. The study focused on comparison of the COVID-19 infected lung tissue gene expression datasets -GSE155241 and GSE150316 with the GEO2R-limma package. The significant up- and downregulated genes were annotated. Further evaluation of the enriched pathways, transcription factors, kinases, noncoding RNAs and drug perturbations revealed the significant molecular mechanisms of the host response. The results revealed a surge in mitochondrial respiration, cytokines, neurodegenerative mechanisms and deprived oxygen, iron, copper, and glucose transport. Hijack of ubiquitination by SARS-CoV-2, hox gene differentiation, histone modification, and miRNA biogenesis were the notable molecular mechanisms inferred. Long non-coding RNAs such as C058791.1, TTTY15 and TPTEP1 were predicted to be efficient in regulating the disease mechanisms. Drugs-F-1566-0341, Digoxin, Proscillaridin and Linifanib that reverse the gene expression signatures were predicted from drug perturbations analysis. The binding efficiency and interaction of proscillaridin and digoxin as obtained from the molecular docking studies confirmed their therapeutic potential. Two overlapping upregulated genes MDH1, SGCE and one downregulated gene PFKFB3 were appraised as potential biomarkers candidates. The upregulation of PGM5, ISLR and ANK2 as measured from their expressions in normal lungs affirmed their possible prognostic biomarker competence. The study explored significant insights for better diagnosis, and therapeutic options for COVID-19. Communicated by Ramaswamy H. Sarma
title: The one thousand faces of solitary brain metastases
Creators: name: Lorusso, Vita
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Neuroradiology brain
subject: Neuroradiology peripheral nerve
subject: Neuroradiology spine
subject: Oncology
subject: Neoplasia
subject: Neuro - Tumor

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References
description: Learning objectives: •To point out the common and the uncommon MRI findings of solitary brain metastases •To underline the complementary information from DWI/DTI, PWI, MRS imaging and, in selected cases, from CT •To build a “step by step” image analysis based...
Sonnenfleckenzeichnung Nr. 76.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.04.1975, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
title: The role of the PET-imaging in radiation diagnostics, prognosis and assessment of the malignant astrocytic tumors recurrent growth treatment efficacy
Creators: name: Kostenikov, Nikolay
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Neuroradiology brain
subject: Neuroradiology peripheral nerve
subject: Neuroradiology spine
subject: Oncology
subject: Neoplasia
subject: Neuro - Tumor

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: The aim of the study was to determine the role of PET-imaging in radiation diagnostics, prognosis and assessment of treatment efficacy for recurrent growth with malignant astrocytic tumors. Recurrent growth (RG) of tumors in a postoperative period...
title: Detection of Ductal Carcinoma In Situ with Full-Field Digital Mammography and Computer-Aided Detection
Creators: name: Lee, Eun Jung
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Breast
subject: Breast - Your latest results

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Double reading of mammograms has been shown to increase cancer detection rates by 15-20% (1-3). By using computer-aided detection (CAD) system, this double reading is performed more efficiently rather than by a second reader radiologist. Multiple...
In-silico studies on Myo inositol-1-phosphate synthase of Leishmania donovani in search of anti-leishmaniasis
Creators: name: Sinha, Mousumi
name: Jagadeesan, Rahul
name: Kumar, Neeraj
name: Saha, Satabdi
name: Kothandan, Gugan
name: Kumar, Diwakar
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Myo-inositol is one of the vital nutritional requirements for the Leishmania parasites’ survival and virulence in the mammalian host. . Myo-inositol-1-phosphate synthase (MIPS) is responsible for the synthesis of myo-inositol in Leishmania, which plays a vital role in Leishmania’s virulence to mammalian hosts. Earlier studies suggest MIP synthase as a potential drug target against which valproate was used as a drug. So, MIP synthase can be used as a target for anti-leishmanial drugs, and its inhibition may help in preventing leishmaniasis. The present study aims to identify valproate's potent analogs as drugs against MIP synthase of L. donovani (Ld-MIPS) with minimum side effects and toxicity to host. In this study, the three-dimensional structure of Ld-MIPS was built, followed by active site prediction. Ligand-based virtual screening was done using hybrid similarity recognition methods. The best 123 valproate analogs were filtered based on their quantitative structure activity relationship (QSAR) properties and were docked against Ld-MIPS using FlexX, PyRx and iGEMDOCK software. The topmost five ligands were selected for molecular dynamics simulation and pharmacokinetic analysis based on the docking score. Simulation studies up to 30 ns revealed that all five lead molecules bound with Ld-MIPS throughout MD simulation and there was no variation in their backbone. All the chosen inhibitors exhibited good pharmacokinetics/ADMET predictions with an excellent absorption profile, metabolism, oral bioavailability, solubility, excretion, and minimal toxicity, suggesting that these inhibitors may further be developed as anti-leishmaniasis drugs to prevent the spread of leishmaniasis. Communicated by Ramaswamy H. Sarma
title: High optical gain in InP-based quantum-dot material monolithically grown on silicon emitting at telecom wavelengths
Creators: name: Balasubramanian, Ramasubramanian
name: Sichkovskyi, Vitalii
name: Corley-Wiciak, Cedric
name: Schnabel, Florian
name: Popilevsky, Larisa
name: Atiya, Galit
name: Khanonkin, Igor
name: Willinger, Amnon J.
name: Eyal, Ori
name: Eisenstein, Gadi
name: Reithmaier, Johann Peter
Publisher: name: Universität Kassel
Year: 2022
Subjects: subject: InP based QD laser on Si
subject: dislocation filtering layers
subject: GaAs on Si
subject: InAs on Si
subject: InAs QD SOA
subject: 530
subject: 600
subject: Indiumphosphid
subject: Quantenpunkt
subject: Laser
subject: Galliumarsenid
subject: Silicium
subject: Indiumarsenid

description: Gefördert im Rahmen eines Open-Access-Transformationsvertrags mit dem Verlag
Plaramia arcata Shear & Marek 2022
Creators: name: Shear, William A.
name: Marek, Paul E.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Chordeumatida
Striariidae
Plaramia
Plaramia arcata

description: Plaramia arcata Shear & Marek, 2022
Plaramia arcata Shear & Marek, 2022b, Zootaxa 5205: 520. Male holotype, male and female paratypes from Jolly Giant Canyon, Arcata Community Forest, Arcata, Humboldt Co., California (FSCA). Known only from localities in Arcata Community Forest, Arcata, Humboldt Co., California.
description: Published as part of Shear, William A. & Marek, Paul E., 2024, The millipede family Striariidae Bollman, 1893. IX. The identity of Striaria californica Cook, 1899, and the new genus Bayaria for Striaria nana Loomis, 1936, with a key to genera and an annotated checklist of the Striariidae (Diplopoda, Chordeumatida, Striarioidea), pp. 524-544 in Zootaxa 5463 (4) on page 538, DOI: 10.11646/zootaxa.5463.4.4, http://zenodo.org/record/11612167
Sonnenfleckenzeichnung Nr. 107.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.05.1975, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
title: Enhancement Patterns in MR Mammography- a pictorial essay
Creators: name: Gala, Foram
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Breast
subject: Breast - Your latest results

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References
description: Learning objectives: To study the various enhancement patterns seen on a MR mammography. To highlight the patterns having high diagnostic...
Sonnenfleckenzeichnung Nr. 278.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.12.1975, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
Sonnenfleckenzeichnung Nr. 285.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.12.1975, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
title: A web-based tool to form a concise differential diagnosis of findings in breast imaging
Creators: name: Talanow, Roland
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Breast
subject: Breast - Your latest results

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References
description: Learning objectives: To develop an easy accessible tool that helps forming a concise differential diagnosis of radiologic findings in breast...
title: Characterization of Pure Ductal Carcinoma in Situ on Dynamic Contrast-Enhanced MRI
Creators: name: Chan, Si-Wa
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Breast
subject: Breast - Your latest results

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: This study was to characterize morphology and contrast enhancement kinetics of pure DCIS on dynamic contrast-enhanced MR imaging (DCE-MRI). We also correlated the MRI features with histopathological grades to asses the differentiation between high...
Sonnenfleckenzeichnung Nr. 15.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 23.01.1975, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
title: Digital Breast Tomosynthesis (DBT): A Useful Adjunct To Two Dimensional Mammography (2DM) For The Preoperative Localization Of Subtle Soft Tissue Lesions
Creators: name: Mombelloni, Sara
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Breast
subject: Breast - Your latest results

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References
description: Learning objectives: To learn how Digital Breast Tomosynthesis (DBT) may help to overcome the difficulties of preoperative wire localization of subtle mammographic...
Virtual screening and molecular simulation study of natural products database for lead identification of novel coronavirus main protease inhibitors
Creators: name: Tripathi, Nancy
name: Goel, Bharat
name: Bhardwaj, Nivedita
name: Sahu, Bharat
name: Kumar, Hemant
name: Jain, Shreyans K.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: 3CL like protease (3CLpro or Mpro) is one of the main proteases of 2019-nCoV. The 3CLpro is a nonstructural protein of SARS-CoV and has an essential role in viral replication and transcription, thus, could be a potential target for anti-SARS drug development. The present study employed ligand- and structure-based approaches to identify the potent inhibitors of 2019-nCoV protease. The e-pharmacophore developed from 3CLpro-1 yielded virtual hits, that were subjected through drug likeliness and PAINS filters to remove interfering compounds. Further comprehensive docking studies, free energy calculations and ADMET studies resulted in two virtual leads- MolPort-000-410-348 and MolPort-002-530-156. The compounds MolPort-000-410-348 and MolPort-002-530-156 displayed good docking score of −12.09 and −13.38 Kcal/mol and free binding energy of −63.34 ± 2.03 and −61.52 ± 2.24 Kcal/mol, respectively. The compounds also exhibited satisfactory predicted ADMET profile and were subjected to molecular dynamic (MD) studies. The MD simulation produced stable complexes of these ligands with 3CLpro protein and ligand RMSD in acceptable limits. Communicated by Ramaswamy H. Sarma