title: RNA-Puzzles Round V: blind predictions of 23 RNA structures
Creators: name: Bu, Fan
name: Adam, Yagoub
name: Adamiak, Ryszard W.
name: Antczak, Maciej
name: De Aquino, Belisa Rebeca H.
name: Badepally, Nagendar Goud
name: Batey, Robert T.
name: Baulin, Eugene F.
name: Boinski, Pawel
name: Boniecki, Michal J.
name: Bujnicki, Janusz M.
name: Carpenter, Kristy A.
name: Chacon, Jose
name: Chen, Shi-Jie
name: Chiu, Wah
name: Cordero, Pablo
name: Das, Naba Krishna
name: Das, Rhiju
name: Dawson, Wayne K.
name: DiMaio, Frank
name: Ding, Feng
name: Dock-Bregeon, Anne-Catherine
name: Dokholyan, Nikolay V.
name: Dror, Ron O.
name: Dunin-Horkawicz, Stanis?Aw
name: Eismann, Stephan
name: Ennifar, Eric
name: Esmaeeli, Reza
name: Farsani, Masoud Amiri
name: Ferré-D’Amaré, Adrian R.
name: Geniesse, Caleb
name: Ghanim, George E.
name: Guzman, Horacio V.
name: Hood, Iris V.
name: Huang, Lin
name: Jain, Dharm Skandh
name: Jaryani, Farhang
name: Jin, Lei
name: Joshi, Astha
name: Karelina, Masha
name: Kieft, Jeffrey S.
name: Kladwang, Wipapat
name: Kmiecik, Sebastian
name: Koirala, Deepak
name: Kollmann, Markus
name: Kretsch, Rachael C.
name: Kurci?Ski, Mateusz
name: Li, Jun
name: Li, Shuang
name: Magnus, Marcin
name: Masquida, BenoÎt
name: Moafinejad, S. Naeim
name: Mondal, Arup
name: Mukherjee, Sunandan
name: Nguyen, Thi Hoang Duong
name: Nikolaev, Grigory
name: Nithin, Chandran
name: Nye, Grace
name: Pandaranadar Jeyeram, Iswarya P. N.
name: Perez, Alberto
name: Pham, Phillip
name: Piccirilli, Joseph A.
name: Pilla, Smita Priyadarshini
name: Pluta, Rados?Aw
name: Poblete, Simón
name: Ponce-Salvatierra, Almudena
name: Popenda, Mariusz
name: Popenda, Lukasz
name: Pucci, Fabrizio
name: Rangan, Ramya
name: Ray, Angana
name: Ren, Aiming
name: Sarzynska, Joanna
name: Sha, Congzhou Mike
name: Stefaniak, Filip
name: Su, Zhaoming
name: Suddala, Krishna C.
name: Szachniuk, Marta
name: Townshend, Raphael
name: Trachman, Robert J.
name: Wang, Jian
name: Wang, Wenkai
name: Watkins, Andrew
name: Wirecki, Tomasz K.
name: Xiao, Yi
name: Xiong, Peng
name: Xiong, Yiduo
name: Yang, Jianyi
name: Yesselman, Joseph David
name: Zhang, Jinwei
name: Zhang, Yi
name: Zhang, Zhenzhen
name: Zhou, Yuanzhe
name: Zok, Tomasz
name: Zhang, Dong
name: Zhang, Sicheng
name: ?Y?A, Adriana
name: Westhof, Eric
name: Miao, Zhichao
Publisher: name: Springer Nature
Year: 2024
Subjects: subject: Statistical methods
subject: Software

description: RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of RNA three-dimensional structure prediction. With agreement from structural biologists, RNA structures are predicted by modeling groups before publication of the experimental structures. We report a large-scale set of predictions by 18 groups for 23 RNA-Puzzles: 4 RNA elements, 2 Aptamers, 4 Viral elements, 5 Ribozymes and 8 Riboswitches. We describe automatic assessment protocols for comparisons between prediction and experiment. Our analyses reveal some critical steps to be overcome to achieve good accuracy in modeling RNA structures: identification of helix-forming pairs and of non-Watson–Crick modules, correct coaxial stacking between helices and avoidance of entanglements. Three of the top four modeling groups in this round also ranked among the top four in the CASP15 contest.