cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The contribution of a neurodevelopment and genetic perspective to our understanding of the pathogenesis of psychotic disorders: the case of 22q11ds and of youth populations
Creators: name: Armando, Marco
Publisher: name: Université de Genève
Year: 2017
Subjects: info:eu-repo/classification/ddc/616.89

description: It has been recently suggested to approach schizophrenia as a neurodevelopmental disorder with psychosis as a late, potentially preventable stage of the illness. While efforts have been conducted to improve our knowledge on distal and proximal risk factors, the researches conducted leave many unanswered questions concerning: 1) the interaction between genes and environment and 2) the role played by specific neurodevelopmental phases. Therefore, we decided to concentrate our research efforts on two specific populations. The 22q11.2 deletion syndrome population can contribute in providing an answer to the first pending question, while the child and adolescent population can help us to provide an answer to the second pending question. This thesis starts with a comprehensive review of these topics. The second part of the thesis is based on a compilation of a selection of my publications. Implications are explored, in terms of clinical practice and treatments strategies.
Computed modeling of humeral mid-shaft fracture treated by bundle nailing
Creators: name: Obruba, Petr
name: Lukáš Čapek
name: Henyš, Petr
name: Kopp, Lubomír
Publisher: name: figshare
Year: 2017
Subjects: subject: 110601 Biomechanics
subject: FOS: Health sciences
subject: 90302 Biomechanical Engineering
subject: FOS: Medical engineering
subject: 90303 Biomedical Instrumentation

description: Elastic bundle nailing is a method for simple humeral mid-shaft fracture osteosynthesis. The aim of our subsequent numerical simulations was to find out torsional and bending stiffness of an elastic bundle nailed humerus. Parametrical 3D numerical model was developed. The diameter of nails was the varying parameter of 1.8, 2.5, 3 and 4 mm. From our results can be seen that the bending stiffness in bundle nailing technique does not depend on nail diameter. On the contrary the torsional stiffness does highly depend on nail diameter. The dependency of the maximal stress on a nail diameter during bending and torsion of the humerus is non-linear. It can be seen that the higher diameter is used the higher stress occurs. Achieved results allow us for the recommendation of optimal nail diameter for this method, which lies between 2 and 3 mm.
Additional file 1: of Effects of megavoltage computed tomographic scan methodology on setup verification and adaptive dose calculation in helical TomoTherapy
Creators: name: Zhu, Jian
name: Bai, Tong
name: Gu, Jiabing
name: Sun, Ziwen
name: Wei, Yumei
name: Li, Baosheng
name: Yin, Yong
Publisher: name: figshare
Year: 2018
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Table S1. Automatic registration options and parameters in TomoTherapy Planned Adaptive module. (DOCX 22 kb)
Pediatric hand injuries – current treatment recommendations for injuries around the finger joints
Creators: name: Steiger, Christina
Publisher: name: Université de Genève
Year: 2022
Subjects: info:eu-repo/classification/ddc/618
Pediatric hand injuries
Pediatric finger fractures
Pediatric finger trauma

description: Pediatric hand injuries are a frequent worldwide cause for trauma consultations. To properly treat these injuries, physicians must be familiar with the particular anatomy and physiology of the growing skeleton. While many current treatment protocols are based on expert opinions this narrative review examined data from published studies to determine evidenced based treatment recommendations if such exist.
Evaluation of acetabular cup initial fixation by using resonance frequency principle
Creators: name: Henyš, Petr
name: Lukáš Čapek
name: Fencl, Jaroslav
name: Procházka, Egon
Publisher: name: figshare
Year: 2017
Subjects: subject: 90302 Biomechanical Engineering
subject: FOS: Medical engineering
subject: 110601 Biomechanics
subject: FOS: Health sciences
subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110506 Orthodontics and Dentofacial Orthopaedics
subject: 91304 Dynamics, Vibration and Vibration Control
subject: FOS: Mechanical engineering

description: The clinical practice shows that the loosening of acetabular cups is more frequent than stem loosening. With standard cups, the incidence of dislocation failure is highest in the first year after arthroplasty implantation. The aim of the study was to quantitatively evaluate the implant-bone stability of a cementless acetabular cup prosthesis by using a device based on resonance frequency analysis. The evaluation of this device was done by finite element analysis and in vitro experiments. It was shown that not all the resonance frequencies can be measured by our device. The resonance frequencies vary within the range of 500–3000 Hz. The proposed power spectrum measurement gives the information about the absolute stiffness of the press-fit implant.
Left–right differences in the proximal femur’s strength of post-menopausal women: a multicentric finite element study
Creators: name: Taddei, Fulvia
name: Falcinelli, Cristina
name: Balistreri, Luca
name: Henyš, Petr
Publisher: name: figshare
Year: 2017
Subjects: subject: 90302 Biomechanical Engineering
subject: FOS: Medical engineering
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: SummaryThe strength of both femurs was estimated in 198 post-menopausal women through subject-specific finite element models. Important random differences between contralateral femurs were found in a significant number of subjects, pointing to the usefulness of further studies to understand if strength-based classification of patients at risk of fracture can be affected by laterality issues.IntroductionSignificant, although small, differences exist in mineral density and anatomy of contralateral proximal femurs. These differences, and their combined effect, may result in a side difference in femurs’ strength. However, this has never been tested on a large sample of a homogenous population.MethodsThe strength of both femurs was estimated in 198 post-menopausal women through CT-derived finite element models, built using a validated procedure, in sideways fall conditions. The impact of the resulting asymmetry on the classification of subjects at risk of fracture was analysed.ResultsThe small difference observed between sides (the right femur on average 4 % stronger than the left) was statistically significant but mechanically negligible. In contrast, higher random differences (absolute difference between sides with respect to mean value) were found: on average close to 15 % (compared to 9.2 % for areal bone mineral density (aBMD) alone), with high scatter among the subjects. When using a threshold-based classification, the right and left femurs were discordant up to over 20 % of cases (K always lower than 0.60) but the left femur was concordant (mean K = 0.84) with the minimum strength between right and left.ConclusionConsidering both femurs may be important when trying to classify subjects at risk of failure with strength estimates. Future studies including fracture assessment would be necessary to quantify the real impact.
Shoulder apprehension, from the joint to the brain
Creators: name: Cunningham, Gregory
Publisher: name: Université de Genève
Year: 2022
Subjects: info:eu-repo/classification/ddc/617

description: Apprehension in shoulder instability is a syndrome more than a symptom. It involves local mechanical factors at the level of the glenohumeral joint, peripheral neurologic factors, and central neurologic factors. These consist in complex alterations in cerebral networks that seem to persist despite surgical stabilization. Persisting apprehension may compromise surgical results and hinder patients performance in sports or even daily life activities. Understanding the multisystemic origin of apprehension is thus important to improve patient care. This Privat Docent thesis is the continuation of the author's Medical Doctor thesis. It includes a line of research projects carried out over the last decade about apprehension. The aim is to regroup and summarize its different causal factors, and to offer a perspective for future development in terms of research and treatment, involving multimodal approaches that range from surgical techniques to cognitive behaviour therapy, and augmented reality.
Additional file 1: of Primary pulmonary amebic abscess in a patient with pulmonary adenocarcinoma: a case report
Creators: name: Liu, Yuan-Yuan
name: Ying, Yue
name: Chen, Chong
name: Hu, Yue-Kai
name: Yang, Fei-Fei
name: Shao, Ling-Yun
name: Cheng, Xun-Jia
name: Huang, Yu-Xian
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Marine Biology

description: Multilingual abstracts in the five official working languages of the United Nations. (PDF 561Â kb)
Occupational Safety and Health Management System Implementation Metrics: Results of a Survey of Manufacturing Companies in a Small Island Developing State
Creators: name: Nathai-Balkissoon, Marcia
Publisher: name: figshare
Year: 2017
Subjects: subject: 91008 Manufacturing Safety and Quality
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 111705 Environmental and Occupational Health and Safety
subject: FOS: Health sciences

description: Cite as: Nathai-Balkissoon, M. 2016. “Occupational Safety and Health Management System Implementation Metrics: Results of a Survey of Manufacturing Companies in a Small Island Developing State.” Journal of the Association of Professional Engineers of Trinidad and Tobago 44:2, 24-34.

Occupational safety and health (OSH) emerged as a field of practice in the 1800s, as workplace safety challenges became exacerbated during the Industrial Revolution. Following a series of United Kingdom Factory Acts starting in the 1800s, the United Kingdom and the United States developed OSH legislation in the 1970s, mandating OSH management system (OSHMS) development within factory operations. In Trinidad and Tobago, a small island developing state (SIDS) in the Caribbean region, a diversification thrust is currently challenging the manufacturing sector to produce faster and in greater quantities, despite resource constraints like human resource availability and capacity. Increased OSH-related risks and costs in manufacturing are likely, making OSHMS development more critical. Although T&T’s OSH legislation was proclaimed in 2004, few statistics about manufacturers’ OSH compliance have been published to date. This study therefore investigated the extent of OSHMS implementation in T&T manufacturing companies in alignment with the country’s OSH Act. A survey was developed and validated for gathering self-reports on implementation of 22 OSHMS elements in companies across 6 manufacturing sub-sectors. Demographic data and general opinions about OSH were also sought. Descriptive statistics and correlation analyses were used to assess OSH perceptions and practices, element implementation, and element inter-relationships. The study found that 9 elements were well-implemented and 13 were under-implemented. Notably, some of the under-implemented elements (e.g. risk assessments, safeguarding, and accident reporting and investigation) were OSH Act mandates. Correlations were also found between certain elements (namely employee participation, top management commitment, dedicated safety practitioner, and continual improvement focus) that influence OSHMS development. Implications of the findings and prospects for the way forward are also discussed.
Additional file 1: of Urinary biomarkers predict advanced acute kidney injury after cardiovascular surgery
Creators: name: Wang, Jian-Jhong
name: Chi, Nai-Hsin
name: Huang, Tao-Min
name: Connolly, Rory
name: Chen, Liang
name: Chueh, Shih-Chieh
name: Kan, Wei-Chih
name: Lai, Chih-Cheng
name: Wu, Vin-Cent
name: Fang, Ji-Tseng
name: Chu, Tzong-Shinn
name: Wu, Kwan-Dun
Publisher: name: figshare
Year: 2018
Subjects: Medicine
Pharmacology
Mathematical Sciences not elsewhere classified
Marine Biology
Computational Biology

description: Supplementary methods: brief introduction of HJV, KIM-1, uNGAL, α-GST, π-GST; Liano’s score, National Taiwan University Study Group on Acute Renal Failure (NSARF) introduction and inotropic equivalents (IE). Table S1. Area under the receiver-operating characteristic curve (AUC) for normalized uHJV, uKIM-1 and serum creatinine for predicting advanced AKI at 3 and 6 h post-surgery. Table S2. Number and percent reclassified in advanced AKI prediction comparing initial model (Normalized [uHJV + uKIM-1]) to updated model (Liano’s + Normalized [uHJV + uKIM-1]) at 3 h post-surgery. Table S3. Logistic regression analysis with variables available for predicting 90 days mortality after hospital discharge and composite outcomes. Figure S1. Receiver-operator characteristic curves for normalized uHJV, uKIM-1 and serum creatinine for predicting advanced AKI at 3 and 6 h post-surgery. Figure S2. Generalized additive models (GAM) plot for the probability of advanced AKI for normalized urinary HJV and KIM-1 at T3 (3 h post-surgery). (DOCX 723 kb)
From Gaucher disease to Parkinson Disease: a new light on the lysosome
Creators: name: De Roux Serratrice, Christine
Publisher: name: Université de Genève
Year: 2022
Subjects: info:eu-repo/classification/ddc/618.97
Gaucher Disease
Parkinson Disease
Lysosome
Lysosomal Storage disorder

description: Gaucher disease type 1 is a lysosomal storage disease with hematological and bone involvement and visceromegaly. Until about twenty years ago it was commonly accepted that neurological involvement could only occur in the most severe forms, type 2 and type 3 Gaucher disease. This principle has been questioned since the first series of patients with Parkinson's disease and Gaucher’s disease were described. It was then clearly demonstrated that the GBA1 mutation, which is responsible for Gaucher’s disease, was also responsible for Parkinson's disease. Glucocerebrosidase, which is active in the lysosome and deficient in Gaucher’s disease, is closely correlated with the accumulation and aggregation of synuclein found in Parkinson's disease. Improving knowledge on rare diseases has an impact on the knowledge of more frequent disease. In this work, we highlight some of the most recent discoveries on Gaucher’s disease through the description of new clinical manifestations, the trend to personalized treatment, and the discovery of new complications. Through these different manifestations associated with Gaucher's disease, we show how an ultra-rare disease can help to better understanding of a very common one and can lead to other therapeutics. As a consequence, glucocerebrosidase represents a promising target to develop further disease modifying treatments in Parkinson’s disease.
Preventing international crisis: an intelligence or policy making issue?
Creators: name: Fondrillon, Ewen
Publisher: name: figshare
Year: 2017
Subjects: subject: 160604 Defence Studies
subject: FOS: Political science

description: International crisis seem inescapable, yet there is always the temptation to look for someone responsible. In these scenario, such as the Iraq invasion of 2003, the intelligence community is an easy target to blame.

However, the intelligence community is not the only part of the intelligence cycle, and ultimately, the decisions and policies are not under its control. Which begs the question: how far does the responsibility for warning of potential crises in international affairs rest with the intelligence analyst and how far with the policy maker?
Additional file 1: of High-luminance perovskite light-emitting diodes with high-polarity alcohol solvent treating PEDOT:PSS as hole transport layer
Creators: name: Wu, Mengge
name: Zhao, Dan
name: Wang, Zijun
name: Yu, Junsheng
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Mental Health
subject: Plant Biology

description: Figure S1. Histogram of the maximum luminance of PeLEDs: (a) based on pristine PEDOT:PSS and (bâ d) based on PEDOT:PSS films treated with MeOH, EtOH, and IPA, respectively. (DOCX 360 kb)
Material model of pelvic bone based on modal analysis: a study on the composite bone
Creators: name: Henyš, Petr
name: Lukáš Čapek
Publisher: name: figshare
Year: 2017
Subjects: subject: 90302 Biomechanical Engineering
subject: FOS: Medical engineering
subject: 110601 Biomechanics
subject: FOS: Health sciences
subject: 90301 Biomaterials
subject: 10303 Optimisation
subject: FOS: Mathematics
subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: 91307 Numerical Modelling and Mechanical Characterisation

description: Digital models based on finite element (FE) analysis are widely used in orthopaedics to predict the stress or strain in the bone due to bone--implant interaction. The usability of the model depends strongly on the bone material description. The material model that is most commonly used is based on a constant Young's modulus or on the apparent density of bone obtained from computer tomography (CT) data. The Young's modulus of bone is described in many experimental works with large variations in the results. The concept of measuring and validating the material model of the pelvic bone based on modal analysis is introduced in this pilot study. The modal frequencies, damping, and shapes of the composite bone were measured precisely by an impact hammer at 239 points. An FE model was built using the data pertaining to the geometry and apparent density obtained from the CT of the composite bone. The isotropic homogeneous Young's modulus and Poisson's ratio of the cortical and trabecular bone were estimated from the optimisation procedure including Gaussian statistical properties. The performance of the updated model was investigated through the sensitivity analysis of the natural frequencies with respect to the material parameters. The maximal error between the numerical and experimental natural frequencies of the bone reached 1.74 % in the first modal shape. Finally, the optimised parameters were matched with the data sheets of the composite bone. The maximal difference between the calibrated material properties and that obtained from the data sheet was 34 %. The optimisation scheme of the FE model based on the modal analysis data provides extremely useful calibration of the FE models with the uncertainty bounds and without the influence of the boundary conditions. A full-text only-view version of the article is available on http://rdcu.be/jXN7
New draft item
Creators: name: Fondrillon, Ewen
Publisher: name: figshare
Year: 2017
Subjects: subject: 160604 Defence Studies
subject: FOS: Political science

description: International crisis seem inescapable, yet there is always the temptation to look for someone responsible. In these scenario, such as the Iraq invasion of 2003, the intelligence community is an easy target to blame.

However, the intelligence community is not the only part of the intelligence cycle, and ultimately, the decisions and policies are not under its control. Which begs the question: how far does the responsibility for warning of potential crises in international affairs rest with the intelligence analyst and how far with the policy maker?
Additional file 1: of A novel chimeric CYP11B2/CYP11B1 combined with a new p.L340P CYP11B1 mutation in a patient with 11OHD: case report
Creators: name: Duan, Lian
name: Shen, Rufei
name: Song, Lingyu
name: Liao, Yong
name: Zheng, Hongting
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Cancer
subject: Virology

description: Table S1. The laboratory and endocrinological evaluation of the proband pre- and post-treatment. (PDF 200 kb)
Clinical predictors in neurosurgery: the example of intra-cranial meningiomas
Creators: name: Corniola, Marco Vincenzo
Publisher: name: Université de Genève
Year: 2021
Subjects: info:eu-repo/classification/ddc/616.8

description:
Predictive scores are used daily in neurosurgery; whether in the context of vertebral metastases requiring surgical stabilization, unruptured cerebral aneurysms or simply to estimate the short and long-mortality in patients with multiple comorbidities. Neurosurgeons constantly refer to predictive tools that allow them to support their clinical judgement and reasoning and lead to coherent patient management.

Once the diagnosis is established, the neurosurgeon (and the multidisciplinary team) managing the patient has to define a reasonable, safe and effective treatment. In order to make a definitive and reliable prognosis according to a specific management, clinical predictors must be applied.

To illustrate the point, intra-cranial meningiomas are used as a paradigm, showing with concrete data and examples how clinical predictors can play a determining role in the daily neurosurgical activity, anticipating as much as possible events such as recurrence, malignant transformation, the occurrence of postoperative complications or the probability of gross total resection, among other specific outcomes.
Sagittal Balance Analysis: key points for thoraco-lumbar spinalsurgery, and prevention of junctional failures
Creators: name: Faundez, Antonio
Publisher: name: Université de Genève
Year: 2021
Subjects: info:eu-repo/classification/ddc/617

description: The concept of Sagittal Balance of the Spine, has very recently gained importance and popularity amongst spine surgeons, but also non-surgical therapists such as rehabilitation doctors, rheumatologists, etc. Since the first description in the 80's of the pelvic incidence angle, which is the cornerstone of sagittal balance, a significant amount of work has been done to best describe the concept and allow us to apply it in surgical treatments. Initially, sagittal balance of the spine has helped us understand, in many operated patients, the etiology of “failed back surgery”, but now it is also becoming a valuable tool to avoid mechanical complications and improve the clinical results of thoraco-lumbar spine surgery. However, very often the concept of sagittal balance analysis is very simplistically reduced to the strict matching of lumbar lordosis to the pelvic incidence angle. In this work, I present the different parameters of sagittal balance that need to be studied, and insist on other aspects that truly describe the aim of the concept: pelvic and spinal parameters, harmony of the curves in standing posture, spinal apex, lumbar lordosis distribution, amongst others. The main goal being to plan the fusion surgeries in the best functional way possible and avoid mechanical complications such as junctional kyphosis and junctional failures. Finally, I also present some ongoing research and the latest developments in sagittal balance analysis, for instance the adaptation of fused lumbar spines in the sitting position. A vast and exciting field of research is still ahead.
Additional file 2: of A novel chimeric CYP11B2/CYP11B1 combined with a new p.L340P CYP11B1 mutation in a patient with 11OHD: case report
Creators: name: Duan, Lian
name: Shen, Rufei
name: Song, Lingyu
name: Liao, Yong
name: Zheng, Hongting
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Table S2. Bioinformatics analysis of the free energy alteration in CYP11B1mut (PDF 82 kb)
Implementing scalable and consistent authorisation across multi-SP environments (AARC-I047)
Creators: name: AARC Consortium Partners
name: AppInt Members
Publisher: name: Zenodo
Year: 2019
Subjects: federated identity management
authorisation
access control
research collaboration
AARC

description: The purpose of this document is to provide information to infrastructures for efficiently implementing access restrictions that are required by the individual communities and e-Infrastructures. The suggestions are given within the setting of the AARC BPA. In this scenario, user communities make use of an SP-IdP-Proxy (including User Attribute services) in order to manage access to resources (end services). The suggestions given address two different topics. One is about providing an interoperable schema to use for expressing authorisation information. This is an extension of the recommendations provided in AARC-G002 - Expressing group membership and role information and AARC-G027 - Specification for expressing resource capabilities. The other topic concerns the organisational architecture for conveying authorisation information. All information within this latter area are derived from the more detailed Deliverable DJRA1.2 on authorisation models.
Community-based addiction treatment: improving access to care for vulnerable groups
Creators: name: Penzenstadler, Louise Emilie
Publisher: name: Université de Genève
Year: 2022
Subjects: info:eu-repo/classification/ddc/616.89
Addiction
Substance use disorder
Community treatment
Outreach treatment

description:
Substance use disorders (SUD) are an important health problem and certain patients with SUD find themselves frequently returning to hospital services (1,2). In order to improve access to care, assertive outreach treatment models such as community treatment have been implemented over the last few decades. However, service use remains high for a number of patients with SUD. Different risk factors associated with high service use can be determined. In order to reduce service use, it is important to identify at-risk patients and their needs, which will allow to better adapt community treatment models. A cohort study (3) examining predictors related to the frequency of emergency department (ED) use among 4,731 patients with substance-related disorders found that high ED users presented more complex and severe conditions and mainly visited ED repeatedly for subacute or non-urgent problems. High ED users were more likely men. They more often had a socioeconomic disadvantage, but also some middle income. Another cohort study (4) analyzing 970 admissions of patients with SUD on factors associated with the length of hospital stay, found that higher Health of Nation Outcome Scales admission scores and number of previous hospitalizations predicted longer stays. This implies that these patients presented higher symptom levels and more psychosocial problems on admission. A study (5) on unplanned readmissions among patients with SUD, showed that longer first hospitalizations reduced the risk of unplanned readmission. A systematic review on assertive community treatment (6) found this model overall beneficial for patients with SUD in particular in increasing treatment engagement. Advance statements were found to be feasible and acceptable tools for patients with SUD to reduce treatment disengagement (7). Overall, the studies show that risk factors for high service use among patients with SUD are the presence of more severe and complex disorders, including co-occurring mental disorders/SUD or physical illness, more psychosocial problems and a history of acute service use. They also indicate the benefits of community treatment and advance statements. In the light of these findings, community-based treatments for SUD and co-occurring disorders, addressing social problems, as well as treatment continuity are necessary to improve access to care and reduce high service use. Future research needs to focus on the impact of community treatment models and how to adapt programs to patients at risk of treatment disengagement and also on the development of new recovery-oriented approaches for patients with SUD.
MYB and HD-ZIP IV homologs related to trichome formation are involved in epidermal bladder cell development in the halophyte Mesembryanthemum crystallinum L.
Creators: name: Siranet Roeurn
name: Narihiro Hoshino
name: Ken-Taro Soejima
name: Inoue, Yuuka
name: Cushman, John C.
name: Agarie, Sakae
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: The common ice plant, Mesembryanthemum crystallinum L., a halophytic new functional leafy vegetable crop, develops epidermal bladder cells (EBCs) on the surfaces of its aerial organs. Our previous studies of the physiological characteristics of the wild-type and the EBC-less mutant indicated that EBCs sequester salt and maintain ion homeostasis within photosynthetically active tissues. The EBC has been thought to be a modified trichome; however, molecular mechanisms governing EBC development in the common ice plant have not been fully understood. Here, we have analyzed the steady-state mRNA abundance of nineteen cotton fiber-related gene homologs and eight Arabidopsis trichome development-related genes, and found that a MYB transcription factor homolog (McMYB2) and a GLABRA2-like gene (McC4HDZ) were preferentially expressed in wild-type plants, whereas a putative TRIPTYCHON (McTRY)- and CAPRICE-like gene (McCPC) were preferentially expressed in the EBC-mutant. The full-length cDNA sequences of these homologs were determined, and constructs containing McC4HDZ and McMYB2 were introduced into an Arabidopsis trichome-less mutant and wild-type plants. Overexpression of McMYB2 in wild-type Arabidopsis increased trichome number, associated with activation of the trichome development-related gene, GLABRA2 (GL2). Moreover, overexpression of McC4HDZ partially complemented trichome development in the trichome-less mutant of gl2-1, and resulted in increased trichome number in wild-type Arabidopsis, associated with the upregulation of key trichome-positive regulators GLABRA1 (GL1) and TRANSPARENT TESTA GLABRA1 (TTG1). These results suggest that McMYB2 and McC4HDZ could be functional in Arabidopsis trichome formation, implying that EBCs of the common ice plant and trichomes of Arabidopsis may share some molecular mechanisms in their development.
A study on the GC-MS analysis of bioactive components and pancreato-protective effect of methanolic extract of Brassica oleracea L. var. botrytis
Creators: name: Sadanandan Rajapriya
name: Geetha, Arumugam
name: Kavasseri Ganesan Kripa
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy

description: The ever-increasing problem of pancreatitis due to alcohol abuse demands evaluation of novel drugs of plant origin. This study explores the therapeutic effects of the methanolic extract of Brassica oleraceae (MEBO) on ethanol and cerulein induced pancreatitis in rats. The MEBO was subjected to GC-MS and HPLC analysis. Male albino Wistar rats were divided into various groups, fed with alcohol (36% of total calories for 5 weeks) and cerulein (20 μg/kg b.wt i.p, weekly thrice for last three weeks) with or without MEBO (40 mg/kg b.wt). Serum lipase, amylase, IL-1β, IL-18, caspase-1, lipid peroxides, oxidative stress index and antioxidant status were assessed in pancreas. Six compounds were identified in GC-MS analysis. Co-administration of MEBO reduced the pancreatic marker enzymes in serum, IL-1β, IL-18 and caspase-1 and increased the antioxidant status of pancreas. The pancreato-protective effect of Brassica oleraceae may be attributed to well-known anti-inflammatory flavonoids, luteolin, quercetin and myricetin.
Persönliche Bilanzierung der Herausforderungen einer Verwitwung im Zeit- und Geschlechtervergleich
Creators: name: Höpflinger, François
name: Spahni, Stefanie
name: Perrig-Chiello, Pasqualina
Publisher: name: Journal of Family Research
Year: 2013

description: Research on bereavement has traditionally focussed on widowhood as either a social or individual event, but rarely under both perspectives. Furthermore, little is known whether existing research results mirror period or cohort effects. The aim of this article is to investigate constancies and changes in the retrospective perception of the challenges of widowhood of elderly women and men living in different decades in Switzerland. Data stem from three questionnaire studies with 1.197 widowed men and women (aged 65-102 years) carried out in 1979, 1994, and 2011. Results reveal that the subjective interpretations mirror the significant improvement of the economic and social situation of widowed individuals in Switzerland over the last decades, particularly for women. In contrast, no significant time effects can be observed with regard to the psychological challenges of marital loss in old age (redefinition of sense of life, feelings of loneliness). These findings suggest, that even in good socio-economic conditions widowhood remains psychologically a critical life event. Zusammenfassung Bisherige Forschung hat die Verwitwung entweder primär als soziales oder als individuelles Ereignis untersucht, selten jedoch wurden beide Perspektiven verbunden. Zudem ist wenig darüber bekannt, inwiefern bisherige Forschungsergebnisse Perioden- oder Kohorteneffekte wiederspiegeln. In diesem Beitrag wird die persönliche Bilanzierung nach der Verwitwung älterer Schweizer Frauen und Männer im Geschlechterund Zeitvergleich untersucht1. Die Datenbasis beruht auf Befragungen von 1.197 verwitweten Frauen und Männern (Alter: 65-102 Jahre), welche 1979, 1994 und 2011 durchgeführt wurden. Während sich die wirtschaftlichen und sozialen Rahmenbedingungen nach einer Verwitwung –namentlich bei Frauen – im Zeitvergleich verbessert haben, zeigen sich bezüglich psychischer Herausforderungen einer Verwitwung keine periodenspezifischen Veränderungen. Psychisch bleibt der Partnerverlust auch bei günstigen Sozialbedingungen ein kritisches Lebensereignis, das individualisiert bewältigt werden muss.
description: Journal of Family Research, Vol 25 No 3 (2013)
Additional file 1: of Comparison between intravenous chemotherapy and intra-arterial chemotherapy for retinoblastoma: a meta-analysis
Creators: name: Chen, Qiuying
name: Zhang, Bin
name: Dong, Yuhao
name: Mo, Xiaokai
name: Zhang, Lu
name: Huang, Wenhui
name: Jiang, Hua
name: Xia, Jiejun
name: Zhang, Shuixing
Publisher: name: figshare
Year: 2018
Subjects: Molecular Biology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer
Science Policy
Hematology

description: The outcomes of meta-analysis in intra-arterial chemotherapy based on ICRB grading. (DOCX 244 kb)
Turbulenzen im Kinderleben. Mütterliche Partnerschaftsbiographien und multiple Übergänge nach elterlicher Trennung
Creators: name: Zartler, Ulrike
name: Berghammer, Caroline
Publisher: name: Journal of Family Research
Year: 2013

description: Experiencing multiple transitions after a parental separation was identified as an important risk factor for children. We investigate for the first time for Austria, how many transitions (i.e. changes in maternal partnership arrangements) children experience and what determines their number. The analyses are based on the Austrian Fertility and Family Survey 1995/96 and the Generations and Gender Survey 2008/09 using a multinomial logistic regression model. The results show that within eight years after parental separation, about 50% of children experience no new cohabitation or marriage of their mother and about 40% experience exactly one. For the majority of children, these changes happen within four years after their parents’ separation. Almost every seventh child with separated parents (13%) experiences multiple transitions. Children with a low-level educated mother and those whose mother is young at the time of separation face a particularly high risk, as well as those living in families with a low age of the youngest child. Moreover, a strong effect of the year of separation could be detected: the probability of experiencing multiple transitions increases strongly over time. Zusammenfassung Nach einer elterlichen Trennung gilt das Erleben multipler Übergänge als Risikofaktor für Kinder. Wir analysieren erstmals für Österreich im Zeitverlauf, wie viele Übergänge, definiert als neuerliche mütterliche Partnerbeziehungen oder Trennungen, Kinder erleben und von welchen Determinanten dies beeinflusst wird. Die Analysen erfolgen mittels multinomialer logistischer Regression auf Basis der österreichischen Daten des Fertility and Family Survey 1995/96 und des Generations and Gender Survey 2008/09. Die Ergebnisse zeigen, dass innerhalb von acht Jahren nach der elterlichen Trennung jeweils rund 50% der Kinder keine und rund 40% genau eine neue Kohabitation (Lebensgemeinschaft oder Ehe) der Mutter erleben, zumeist in den ersten vier Jahren nach der elterlichen Trennung. Fast jedes siebte Kind mit getrennten Eltern (13%) macht die Erfahrung multipler Übergänge. Erklärende Faktoren sind niedriges Alter der Mutter zum Zeitpunkt der Trennung, geringes mütterliches Bildungsniveau sowie niedriges Alter des jüngsten Kindes. Des Weiteren zeigt sich ein deutlicher Effekt des Trennungsjahres: die Wahrscheinlichkeit für das Erleben multipler Übergänge ist im Zeitverlauf markant angestiegen.
description: Journal of Family Research, Vol 25 No 3 (2013)
Role of ERCP for the diagnosis of indeterminate biliary stenosis and the treatment of benign (non-neoplastic) biliary stenosis in adults
Creators: name: Bichard, Philippe
Publisher: name: Université de Genève
Year: 2022
Subjects: info:eu-repo/classification/ddc/616
Biliary stenosis
ERCP
Bile cytopathology
Single operator cholangioscopy
Biliary prosthesis
Alveolar echinococcosis

description:
In the first part of this thesis, the diagnostic role of Endoscopic Retrograde Cholangiopancreatography (ERCP) in suspected malignant biliary stenosis) is reported. Sophisticated techniques have been proposed to optimize the diagnostic accuracy of this procedure. We report the major contribution of a simple and safe procedure: bile cytological analysis performed during ERCP in combination with cytological brushing illustrated by our experience detailed in 2 publications. The role of ERCP with a single operator cholangioscopy (SOC) for the diagnosis of indeterminate biliary stenosis and its significant impact on patient management is reported in a third publication.

In the second part, the role of therapeutic ERCP is detailed for the treatment of benign biliary stenosis. The role of cSEMS for biliary post-operative stenosis is reported along with our local experience. In addition, ERCP stenting is suggested as an alternative therapy for the particular case of biliary stenosis of alveolar echinococcosis. These two aspects are illustrated by publications.

ERCP remains essential in 2021 for the diagnosis of indeterminate biliary stenosis and the treatment of benign biliary stenosis. In the concluding chapter, we focus on current challenges for teaching ERCP to trainees and standards of performance for practitioners after initial training for this demanding endoscopic technique
Additional file 1: of Prompting with electronic checklist improves clinician performance in medical emergencies: a high-fidelity simulation study
Creators: name: Sevilla-Berrios, Ronaldo
name: OâHoro, John
name: Schmickl, Christopher
name: Erdogan, Aysen
name: Chen, Xiaomei
name: Garcia Arguello, Lisbeth
name: Dong, Yue
name: Kilickaya, Oguz
name: Pickering, Brain
name: Kashyap, Rahul
name: Gajic, Ognjen
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Structure of the study design. (DOCX 46Â kb)
NIMBLE: A language for algorithms for graphical models embedded in R
Creators: name: Valpine, Perry De
Publisher: name: figshare
Year: 2017
Subjects: subject: Applied Computer Science
subject: Computer Software
subject: FOS: Computer and information sciences
subject: 80204 Mathematical Software
subject: 80205 Numerical Computation
subject: 80306 Open Software
subject: 80308 Programming Languages

description: This poster describes the NIMBLE software package for programming statistical algorithms for hierarchical statistical models (graphical models) from R. See r-nimble.org for more information.
Väterzeit – das Elterngeld als Beschleuniger von Gleichstellung?
Creators: name: Trappe, Heike
Publisher: name: Journal of Family Research
Year: 2013

description: This contribution centres on men who claim parental leave benefits in the federal states of Bavaria, Mecklenburg-Western Pomerania and Schleswig-Holstein. The analyses are based on register data collected by local authorities for children born between 2007 and 2009. First, it is asked about the determinants underlying the take-up of fathers’ parental leave benefits. Then, couples with different durations of fathers’ parental leave are investigated more closely. Fathers’ decision to take any parental leave follows essentially economic considerations within the couple. Female partners’ employment and their relative earnings have a positive impact. Couples where fathers’ parental leave exceeds the “daddy quota” represent quite a select group that has become smaller over time. Living in a non-marital union or in a large city, having more children as well as female partners’ particular situation (e.g., self-employment, in education) facilitate a longer parental leave of fathers. Zusammenfassung Im Zentrum des vorliegenden Beitrags steht der Elterngeldbezug von Vätern im Kontext der Partnerschaft in den Bundesländern Bayern, Mecklenburg-Vorpommern und Schleswig-Holstein. Grundlage der Analysen sind von den Elterngeldstellen erhobene Daten für zwischen 2007 und 2009 geborene Kinder. Es wird danach gefragt, welche Paare überhaupt einen Partnerantrag stellen und wodurch sich Paare mit unterschiedlicher Dauer des Elterngeldbezugs durch Väter voneinander unterscheiden. Die Entscheidung für einen Partnerantrag folgt im Wesentlichen aus ökonomischen Theorien abgeleiteten Erwartungen, denn eine Erwerbstätigkeit und ein hohes Einkommen der Frau begünstigen diese. Väter, bei denen der Elterngeldbezug mit einer über die „Bonusmonate“ hinausgehenden Elternzeit einhergeht, sind eine sehr selektive Gruppe, die im Zeitverlauf sogar kleiner geworden ist. Ein nichteheliches Zusammenleben, das Leben in einer Großstadt, eine höhere Anzahl von Kindern sowie eine spezifische Lebenssituation der Partnerin (z.B. selbstständige Tätigkeit, Beendigung einer Ausbildung) wirken sich positiv auf eine längere Elternzeit des Vaters aus.
description: Journal of Family Research, Vol 25 No 2 (2013): Elterngeld und Elternzeit in Deutschland: Ziele, Diskurse und Wirkungen
Einführung in das Schwerpunktthemenheft. Elterngeld und Elternzeit in Deutschland: Ziele, Diskurse und Wirkungen
Creators: name: Bujard, Martin
Publisher: name: Journal of Family Research
Year: 2013

description: -
description: Journal of Family Research, Vol 25 No 2 (2013): Elterngeld und Elternzeit in Deutschland: Ziele, Diskurse und Wirkungen
Effetti di differenti livelli di inclusione, nelle diete, di farina di Hermetia illucens, sulla crescita, biochimica del plasma e qualità del filetto di orata (Sparus aurata)
Creators: name: Cenci, Giacomo
Publisher: name: Zenodo
Year: 2021

description: Effetti di differenti livelli di inclusione, nelle diete, di farina di Hermetia illucens, sulla crescita,biochimica del plasma e qualità del filetto di orata (Sparus aurata)

Alma Mater Studiorum - Università di BolognaSCUOLA DI AGRARIA E MEDICINA VETERINARIACorso di Laurea Magistrale in Sicurezza e Qualità delle Produzioni Animali
Additional file 2: of Comparison between intravenous chemotherapy and intra-arterial chemotherapy for retinoblastoma: a meta-analysis
Creators: name: Chen, Qiuying
name: Zhang, Bin
name: Dong, Yuhao
name: Mo, Xiaokai
name: Zhang, Lu
name: Huang, Wenhui
name: Jiang, Hua
name: Xia, Jiejun
name: Zhang, Shuixing
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Computational Biology

description: The outcomes of meta-analysis in intravenous chemotherapy based on ICRB grading. (DOCX 280 kb)
MyGene2 automated match report: ATAD3B
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2017
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for ATAD3B.
Doctoral thesis recital (piano)
Creators: name: Lee, Yunjin, 1989-
Publisher: name: The University of Texas at Austin
Year: 2020
Subjects: Sonatas (Piano)
Variations (Piano)
Polonaises (Music)
Piano music

description: Sonata in B minor, K. 27 / Sonata in E major, K. 162 / Domenico Scarlatti -- 15 variations and fugue in E-flat major, op. 35 : "Eroica" / Ludwig van Beethoven -- Polonaise-Fantaisie in A-flat major, op. 61 / Frédéric Chopin -- Sonata no. 4 in C minor, op. 29 / Sergei Prokofiev -- [The love / Hee Jung Park ; arranged by Jeong Ah Chun]
Additional file 2: of Prompting with electronic checklist improves clinician performance in medical emergencies: a high-fidelity simulation study
Creators: name: Sevilla-Berrios, Ronaldo
name: OâHoro, John
name: Schmickl, Christopher
name: Erdogan, Aysen
name: Chen, Xiaomei
name: Garcia Arguello, Lisbeth
name: Dong, Yue
name: Kilickaya, Oguz
name: Pickering, Brain
name: Kashyap, Rahul
name: Gajic, Ognjen
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology

description: Example of standardized clinical scenario. (DOCX 99Â kb)
Additional file 3: of Comparison between intravenous chemotherapy and intra-arterial chemotherapy for retinoblastoma: a meta-analysis
Creators: name: Chen, Qiuying
name: Zhang, Bin
name: Dong, Yuhao
name: Mo, Xiaokai
name: Zhang, Lu
name: Huang, Wenhui
name: Jiang, Hua
name: Xia, Jiejun
name: Zhang, Shuixing
Publisher: name: figshare
Year: 2018
Subjects: Molecular Biology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer
Science Policy
Hematology

description: The outcomes of meta-analysis in intra-arterial chemotherapy based on RE grading. (DOCX 191 kb)