cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
PI15, a novel secreted WNT-signaling antagonist, regulates chondrocyte differentiation
Creators: name: Kawaue, Hiroka
name: Rojasawasthien, Thira
name: Dusadeemeelap, Chirada
name: Matsubara, Takuma
name: Kokabu, Shoichiro
name: Addison, William N.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: During the development of the vertebrate skeleton, the progressive differentiation and maturation of chondrocytes from mesenchymal progenitors is precisely coordinated by multiple secreted factors and signaling pathways. The WNT signaling pathway has been demonstrated to play a major role in chondrogenesis. However, the identification of secreted factors that fine-tune WNT activity has remained elusive. Here, in this study, we have identified PI15 (peptidase inhibitor 15, protease Inhibitor 15, SugarCrisp), a member of the CAP (cysteine rich secretory proteins, antigen 5, and pathogenesis related 1 proteins) protein superfamily, as a novel secreted WNT antagonist dynamically upregulated during chondrocyte differentiation. ATDC5 cells, C3H10T1/2 micromass cultures and primary chondrocyte cells were used as in vitro models of chondrogenesis. PI15 levels were stably depleted or overexpressed by viral shRNA or expression vectors. Chondrogenesis was evaluated by qPCR gene expression analysis and Alcian blue staining. Protein interactions were determined by coimmunoprecipitation assays. shRNA-mediated knockdown of PI15 in ATDC5 cells, C3H10T1/2 cells or primary chondrocytes inhibits chondrogenesis, whereas the overexpression of PI15 strongly enhances chondrogenic potential. Mechanistically, PI15 binds to the LRP6 WNT co-receptor and blocks WNT-induced LRP6 phosphorylation, thus repressing WNT-induced transcriptional activity and alleviating the inhibitory effect of WNT signaling on chondrogenesis. Altogether, our findings suggest that PI15 acts as a key regulator of chondrogenesis and unveils a mechanism through which chondrocyte-derived molecules can modulate WNT activity as differentiation proceeds, thereby creating a positive feedback loop that further drives differentiation.
The Effects of Focused Intervention on Tenth-Grade Students’ Reading Comprehension Level
Creators: name: English, Mashonah
Publisher: name: Maryland Shared Open Access Repository
Year: 2016
Subjects: subject: Reading
subject: Comprehension
subject: Intervention
subject: High School
subject: Education -- Research papers (Graduate).

description: The purpose of this study was to examine the effects of reading intervention strategies on tenth-grade students’ reading levels. This was a quasi-experimental study that used a single group of students who were not randomly selected. The students in this study were tenth graders in a large vocational technical high school. The class of participants contained 13 girls and eight boys. The study used the results of the I-Ready Adaptive Diagnostic Exam. The data on the pre- and post-test were analyzed utilizing the dependent or paired t-test. The null hypothesis indicated that the use of targeted intervention would have no impact on the reading levels of the study participants. The null hypothesis was rejected since there was a significant increase in students’ reading levels.
Additional file 1 of Microbiologically confirmed infections and antibiotic-resistance in a national surveillance study of hospitalised patients who died with COVID-19, Italy 2020–2021
Creators: name: Floridia, Marco
name: Giuliano, Marina
name: Monaco, Monica
name: Palmieri, Luigi
name: Lo Noce, Cinzia
name: Palamara, Anna Teresa
name: Pantosti, Annalisa
name: Brusaferro, Silvio
name: Onder, Graziano
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file1. Table S1. Characteristics of 1390 patients with superinfection from the ISS mortality database of patients deceased in hospital with COVID-19.
Whole genome sequencing service : investigating healthcare associated infections
Creators: name: Parcell, Benjamin John
Publisher: name: University of St Andrews
Year: 2021

description: Advances in the field of whole genome sequencing (WGS) have resulted in lowered costs, increased capacity and improved reproducibility of results. WGS now has the potential to revolutionise the investigation and management of healthcare-associated infection (HAI) outbreaks replacing conventional typing systems. The main objective of this work was to establish a WGS service for the investigation of suspected HAI outbreaks that could confirm or refute outbreaks in real-time in the National Health Service (NHS). WGS results were compared to conventional typing results and the practical barriers and clinical benefits associated with implementing this technology in a clinical environment were identified. Over a five year period a WGS service was used to investigate twenty one suspected outbreaks. The challenges of establishing a WGS service fell into six main areas: infrastructure; performance and quality assessment of data and processing; pipelines and management of reference databases; when to use WGS; clinical interpretation of results and finally when to use increased WGS discriminatory power in outbreak investigations. The clinical benefits of translating genomics into clinical practice comprised five themes: WGS can provide results with greater granularity than routine typing methods; genomic analysis can enhance the detection of “alert organisms’”; WGS can replace the need for multiple tests allowing streamlining of clinical microbiology services; genomic analysis can be used to rule out outbreaks and therefore minimise disruption to healthcare services; WGS can be utilised to investigate new resistance mechanisms. Identifying these practical barriers and clinical benefits informed the development of a clinical decision aid to assist staff on how best to utilise a WGS service. Implementing WGS as a standard of care in real-time was found to be a major advance in day-to-day IPC practice which is particularly relevant in view of the global threat we face with increasing antimicrobial resistance (AMR) and limited treatment options.
Reactions of mountain pine beetles (Dendroctonus ponderosae (Coleoptera: Curculionidae, Scolytinae) to diets presented with mutualist and non-mutualist fungi
Creators: name: Chan, Adrian
Publisher: name: The University of British Columbia
Year: 2015

description: The interaction between Dendroctonus ponderosae (mountain pine beetle) and an unknown black stain fungi is studied with an experiment that looked at whether beetles had a preference for entering diets that had been mixed with either black stain fungi, blue stain fungi (Grossmania claverigera), or simply malt extract agar. It was predicted that the unknown black stain fungi would be avoided by the beetles because it is not one of the fungal species that Dendroctonus ponderosae has a symbiotic relationship with. Analysis of the results with a chi square test for independence showed that the beetles showed no preference. Even though the beetles did not show a preference, it is possible that competition for subcortical resources and phloem between mutualist and non-mutualist fungal species results in a suppressed mountain pine beetle development. The potential for mountain pine beetle expansion will depend on whether the black stain fungus is more successful than the mycangial symbionts that the beetle invades with.
Investigating nanoparticle based vaccines for the optimal induction of CD8 + T cell responses against minimal peptide epitopes
Creators: name: KIRSTY LEE WILSON
Publisher: name: Monash University
Year: 2017
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Peptide based vaccines are safe and cost effective, however, they require an adjuvant to enhance the immune response. Current licensed adjuvants are poor inducers of CD8 T cells, thus there is a need for novel adjuvant systems. This study established that it is possible to induce potent CD8 T cell responses to minimal peptide targets, when using delivery systems such as peptides bound to nanoparticles, or nanoparticles in combination with immune potentiators. This study advances the understanding of principles for developing a new generation non-inflammatory vaccines against minimal peptide CD8 T cell targets.
IMPACT OF EMPLOYMENT ON POVERTY REDUCTION CASE STUDY RWANDA
Creators: name: Nshimyumukiza, Francois
Publisher: name: Zenodo
Year: 2024

description: In this insightful study, delve into the intricate relationship between employment and poverty reduction in Rwanda, a country on a transformative journey towards economic stability and growth. This book, grounded in empirical research and comprehensive analysis, explores how employment—particularly in the agricultural and non-agricultural sectors—affects poverty levels.

Drawing on the influential theories of Paul Krugman and the research of Ravallion, this book emphasizes the dual role of labor productivity: boosting profits for the poor and reducing the cost of goods, thereby enhancing the quality of life for both rural and urban populations. The study reveals a significant negative correlation between private farm and non-farm employment and poverty, highlighting the effectiveness of modern farming practices and the robust performance of non-farm businesses in alleviating poverty.

The book further examines how education levels influence poverty reduction and discusses the limited impact of household head gender and main job status on poverty outcomes. By analyzing various household characteristics and employment variables, the research provides valuable insights into the factors that contribute to poverty reduction in Rwanda.
METHODOLOGY FOR FORMING THE SPIRITUAL DEVELOPMENT OF A PERSON ON THE BASIS OF NATIONAL VALUES
Creators: name: Xomidov, Muhammadzakiy
Publisher: name: Zenodo
Year: 2025

description: This research explores the methodology of shaping an individual's spiritual maturity based on national values. The study focuses on the integration of cultural heritage, moral principles, and traditional values into the educational and upbringing processes. It highlights how national values such as patriotism, respect for elders, social responsibility, and moral integrity contribute to the spiritual development of personality. The work also presents practical methods and pedagogical-psychological approaches aimed at enhancing the effectiveness of moral education. The results of the study can be applied in educational institutions, family upbringing, and social development programs to foster spiritually mature and culturally rooted individuals.
Additional file 1 of Recurrent heart failure hospitalizations increase the risk of mortality in heart failure patients with atrial fibrillation and type 2 diabetes mellitus in the United Kingdom: a retrospective analysis of Clinical Practice Research Datalink database
Creators: name: Lahoz, Raquel
name: Fagan, Ailís
name: McSharry, Martin
name: Proudfoot, Clare
name: Corda, Stefano
name: Studer, Rachel
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1. Primary care coding schemes for identifying HF diagnoses and HFHs.
Artificial inoculation of Phytophthora ramorum on Pseudotsuga menziesii and Larix kamperfi bolts to assess lineage aggression, survival and detection methods
Creators: name: Sheppard, Julie
Publisher: name: The University of British Columbia
Year: 2015

description: This experiment tested the survival, and aggression of the four different lineages of P. ramorum (NA1, NA2, EU1, EU2) on Douglas fir bolts. The average lesions size produced at 4 weeks was 7.47cm, at 8 weeks was 13.125cm and at 12 weeks was 6.18cm. There was no significant difference in aggression between the four lineages, but the EU2 lineage produced the largest lesions after 4 weeks with the most variability (8.375±1.99). Re-isolation of the pathogen was poor, with only 16% success after 4 weeks, 4% after 8 weeks and 0% after 12 weeks. Molecular techniques were better able to detect the pathogen, showing presence of the pathogen 9 weeks after exposure to air. This however does not indicate viability and further analysis needs to be done to confirm survival of the pathogen over time. Overall this experiment confirms the susceptibility of Douglas fir to all four lineages of P. ramorum, and indicates that there is potential for survival on logs.
Photoelectrochemical Synthesis of Benzo[b]phosphole Oxides via Sequential P–H/C–H Bond Functionalizations
Creators: name: Saha, Nayan
name: König, Burkhard
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: photoelectrochemistry; organocatalysis; annulation; photoredox; C−P bond formation
subject: 540 Chemie

description: Benzo[b]phosphole oxides are important P-heterocycles that find applications in optoelectronics due to their inherent photophysical properties. Traditional routes for the synthesis of such molecules from readily available precursors require stoichiometric amounts of transition metal salts, bases, oxidants, and additives, thereby lacking efficiency. Photochemical pathways still need a terminal oxidant to complement the photocatalytic cycle, whereas electricity may be a viable oxidant. Hence, photoelectrochemistry (PEC), combining photocatalysis and synthetic organic electrochemistry, was used to simplify the synthetic protocols. We use the potency of 4CzIPN for the consecutive P–H/C–H bond functionalizations for preparing benzo[b]phosphole oxides from secondary phosphine oxides and nonactivated internal alkynes with up to 93% yields and with good functional group tolerance. Detailed mechanistic investigations confirm an intermolecular electron transfer between 4CzIPN and aryl secondary phosphine oxides upon photoexcitation. The photocatalyst is regenerated by anodic oxidation.
Physical Attributes, Squat Ability, and Long Jump Performance of Maguindanaon Junior High School Athletes
Creators: name: Arvie A. Mangi*
name: Susan P. Losaňes
name: Haron A. Mohamad
Publisher: name: Zenodo
Year: 2025
Subjects: Athletes, Physical Attributes, Physical Education, Squat Ability, Long Jump, Public School Students.

description: Abstract: This study explores how key physical attributes, including height, weight, arm length, and leg length, impact on athlete squat ability and ultimately, their long jump performance. This study was utilized a mixed method approach, combining a survey questionnaire to gather quantitative data on physical attributes, squat ability, and long jump performance. It was followed by semi-structured interviews to delve deeper into athletes' qualitative experiences and perceptions regarding their training and performance. The data was gathered using a validated research-made questionnaire. Mean, standard deviation (sd), correlation coefficient (r), and p-value were the statistical tools used to determine the relationship between physical attributes, squat ability, and long jump performance and thematic analysis, frequency count, and qualitative analysis to identify common patterns and insights regarding athletes’ backgrounds. The analyzed and interpreted data revealed that participants' height, weight, and arm length show a significant moderate association. Hence, multiple regressions show that weight best predicts long jump performance. Participants’ level of squat ability showed a significant and very strong association with long jump performance. Most participants had experience in training, competition, technical skills support, and the environment. Thus, it resulted in a moderate level of long jump performance. It is concluded that among the physical attributes, weight is the best predictor of long jump performance; squat ability had a significant and very strong association with long jump performance, and athletes with training and competition experience, good athletics skills, and strong support have a strong significant effect on long jump performance.
Barjols, atelier Fabre, fabrication d'un tambourin, blason de la famille de Boisgelin sculpté sur un morceau de noyer
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
Supplementary document for Using angle-selective optical film to enhance light extraction of thin-film encapsulated 3D reflective pixel for OLED displays - 6169268.pdf
Creators: name: Liao, Po-Hsiang
name: Lee, Wei-Kai
name: Lee, Chang-Cheng
name: Huang, Chun-Wei
name: Wen, Sheng-Wen
name: Chen, Yi-Ting
name: Chen, Chung-Chia
name: Lin, Wan-Yu
name: Kwak, B.
name: Visser, Robert
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: supplement 1
Impact of simulated mechanical defoliation caused by Zeiraphera canadensis (spruce bud moth) on food resource availability on Picea glauca (white spruce) in subsequent years
Creators: name: Then, May Anne
Publisher: name: The University of British Columbia
Year: 2015

description: Zeiraphera canadensis (spruce bud moth) larvae feed on newly burst buds of Picea glauca (white spruce). It has been observed that Z. canadensis herbivory on apical shoots leads to loss of apical dominance and the release of dormant buds in subsequent years due to shoot damage. It has also been observed that there is greater success of larval colonization in years following herbivory. This paper explores whether Z. canadensis herbivory increases the amount of food resource available for subsequent generations by simulating mechanical defoliation in a controlled experiment. The results rejected our original hypothesis and total buds produced was found to decrease with increasing herbivory. We did not observe positive resource regulation feedback in the spruce bud moth and white spruce system.
The role of speech pathology weekend service in stroke inpatient rehabilitation
Creators: name: Davies, Lidia
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 420110
subject: Speech pathology
classificationCode: 420109
subject: Rehabilitation

description: Submitted in partial fulfillment of the requirements for the degree of Master of Applied Science to the School of Allied Health, Human Services and Sport, La Trobe University, Victoria, Australia.
Additional file 1 of Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank
Creators: name: Fawcett, Katherine A.
name: Demidov, German
name: Shrine, Nick
name: Paynton, Megan L.
name: Ossowski, Stephan
name: Sayers, Ian
name: Wain, Louise V.
name: Hollox, Edward J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Supplementary ClinCNV methods and benchmarking results, and Figures S1–S5.
title: Modification management for planning and construction processes
Creators: name: Huhnt, Wolfgang
name: Richter, Sven
Publisher: name: Bauhaus-Universität Weimar
Year: 2010
Subjects: subject: Angewandte Informatik
subject: Angewandte Mathematik
subject: Architektur
subject: Computerunterstütztes Verfahren
subject: 000
subject: 510

description: Planning and construction processes are characterized by the peculiarity that they need to be designed individually for each project. It is necessary to set up an individual schedule for each project. As a basis for a new project, schedules from already finished projects are used, but adaptions are always necessary. In practice, scheduling tools only document a process. Schedules cover a set of activities, their duration and a set of interdependencies between activities. The design of a process is up to the user. It is not necessary to specify each interdependency, and completeness and correctness need to be checked manually. No methodologies are available to guarantee properties such as correctness or completeness. The considerations presented in the paper are based on an approach where a planning and a construction process including the interdependencies between planning and construction activities are regarded as a result. Selected information need to be specified by a user, and a proposal for an order of planning and construction activities is computed. As a consequence, process properties such as correctness and completeness can be guaranteed with respect to user input. Especially in Germany, clients are allowed to modify their requirements at any time. This leads to modifications in the planning and construction processes. This paper covers a mathematical formulation for this problem based on set theory. A complex structure is set up covering objects and relations; and operations are defined that guarantee consistency in the underlying and versioned process description. The presented considerations are based on previous work. This paper can be regarded as the next step in a series of previous work describing how a suitable concept for handling, planning and construction processes in civil engineering can be formed.
description: Internationales Kolloquium über Anwendungen der Informatik und Mathematik in Architektur und Bauwesen : 07. bis 09.07.2009, Bauhaus-Universität Weimar, vol. 18, 2009
Additional file 2 of What evidence exists on the impact of climate change on some of the worst invasive fish and shellfish? A systematic map protocol
Creators: name: Azra, Mohamad Nor
name: Noor, Mohd Iqbal Mohd
name: Sung, Yeong Yik
name: Lawrence, Elizabeth R.
name: Ghaffar, Mazlan Abd
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Additional file 2. Search strategy.
MPEC 2024-Q45 : 2024 QL
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 QL

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Simplifying Access to Space Weather Data using the HAPI Data Access Standard
Creators: name: Vandegriff, Jon
name: Weigel, Robert
name: Faden, Jeremy
name: Antunes, Alexander
Publisher: name: Zenodo
Year: 2025
Subjects: Heliophysics
data
standards
API

description: As more space weather measurements, models, and forecasts become available, standard ways to access the resulting data become increasingly important. Unpleasant data wrangling efforts throughout analysis and operations processes can be reduced by leveraging standards.  The Heliophysics Application Programming Interface (HAPI) is a COSPAR endorsed and NASA supported standard for accessing time series data, and it is being adopted by both the Space Weather Prediction Center (SWPC) and the National Environmental Satellite, Data, and Information Service (NESDIS). Multiple NASA Heliophysics archives now make their data available using HAPI, as do several international projects and archives with space mission data, ground-based measurements, and space weather indices.

We describe the basics of the HAPI standard, the extent of its adoption, and how existing HAPI-enabled tools can benefit both data providers and data users.
Young farmers in the Lower Mainland
Creators: name: Gichungwa, Hazel
Publisher: name: The University of British Columbia
Year: 2015

description: Currently less than 5% of the farmers in the Lower Mainland are below the age of 35. With an increasingly aging population, questions are being raised on the consequences concerning the impacts of so few young farmers in the agriculture sector. The research question for this paper is: what are the barriers and opportunities facing young barriers in the Lower Mainland? In this paper, the term “young farmer” will be coined to farmers under the age of 35. The paper is based on a literature review and expert and farmer interviews. It concludes the barriers facing young farmers to be: land accessibility, financial constraints and insufficient knowledge and training. Young farmers have tackled each obstacle in diverse ways. There is a shift from mechanization and large scale farming (i.e., industrial farming) to a more small-scale organic farming practice. New methods of farming have been formed to overcome the land accessibility obstacle; land sharing and backyard farming being the most common. Low interest loans by Farm Folk City Folk and other organizations are aimed at providing start-up capital. Additionally, there have been multiple training and apprenticeship programs that have been developed over the last few years tailored to assisting new and current young farmers. The study recommends that there should be more incentives for people to convert their backyards to farms, such as tax reduction for people who produce a certain amount in the backyard or communities that engage in a certain amount of agriculture. Further research is recommended on the contribution to climate change by agriculture, especially with the increase in the mechanization of agriculture. Lastly, further research should be directed on the impact industrial food production has had on the perception the population has on the cost of food.
Microbial Dynamics and Biochemical Complexity in Traditional Palm Wine Fermentation: Insights into Flavor Development and Health Implications
Creators: name: Okafor, O.I.*
name: Odibo, F.J.C.
name: Ajogwu, T.M.C.
name: Obianom, A.O.
name: Aniekwu, C.C.
Publisher: name: Zenodo
Year: 2025
Subjects: Elaeis guineensis, fermentation, Palm wine, pasteurization, Saccharomyces cerevisiae

description: Abstract: Palm wine, a traditional alcoholic beverage derived from the spontaneous fermentation of palm sap, serves as a cultural and nutritional staple across tropical regions of Africa, Asia, and Latin America. This review delves into the intricate microbial ecosystems and biochemical pathways that underpin palm wine production, emphasizing its unique terroir-driven sensory profile and health-promoting properties. Unlike commercial fermented beverages, palm wine’s fermentation relies on autochthonous microbial communities predominantly Saccharomyces cerevisiae, Lactobacillus plantarum, and Acetobacter species that are shaped by biogeographical factors such as palm species (Elaeis guineensis in West Africa, Borassus flabellifer in South Asia), climatic conditions, and artisanal tapping practices. These microbes orchestrate a dynamic metabolic interplay, converting sucrose-rich sap into ethanol (up to 5.28% w/v), organic acids (lactic acid: 0.05–4.7%; acetic acid: 0.01–0.24%), and volatile compounds (e.g., ethyl lactate, phenylethyl alcohol), which collectively define its effervescence, acidity, and complex flavor bouquet. Beyond its role as a social lubricant, palm wine harbors significant nutritional and therapeutic value, including B-vitamins, potassium, magnesium, and antioxidants. Emerging evidence highlights its probiotic potential, with lactic acid bacteria and yeast strains exhibiting antimicrobial, anti-inflammatory, and anti-diabetic properties. However, challenges such as rapid spoilage (<48 hours), inconsistent ethanol content, and contamination risks (e.g., Klebsiella pneumoniae) underscore the need for innovative preservation strategies, including controlled fermentation with tailored starter cultures and non-thermal pasteurization. By elucidating the nexus between microbial ecology, flavor chemistry, and health benefits, this work advocates for palm wine’s recognition as a functional food and its integration into sustainable agro-industrial value chains.
Additional file 3 of What evidence exists on the impact of climate change on some of the worst invasive fish and shellfish? A systematic map protocol
Creators: name: Azra, Mohamad Nor
name: Noor, Mohd Iqbal Mohd
name: Sung, Yeong Yik
name: Lawrence, Elizabeth R.
name: Ghaffar, Mazlan Abd
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Additional file 3. Benchmark article.
LEKSIKOGRAFIYANING NAZARIY ASOSLARI
Creators: name: Djuraeva, Madina
Publisher: name: Zenodo
Year: 2024

description: Lug`at – so‘z, frazema, parema, morfema va boshqalarning belgilangan maqsadga ko‘ra, ma’lum qonuniyat hamda ehtiyoj asosida tartibga solingan yig‘indisi, leksikografiya – lug‘at va uning tuzilishi, yaratilish tamoyillari haqidagi bilim – ta’limot. Leksikografiya – yunoncha “lexis” – so‘z, “grapho” – yozaman, yozish, yozilgan kabi ma’nolarni ifodalaydi.
:unas
Creators: name: :None
Publisher: name: DuEPublico: Duisburg-Essen Publications online, University of Duisburg-Essen, Germany
Year: 2023
Subjects: subject: 940

description: Niederrhein-Magazin: Zeitschrift der Niederrhein-Akademie/Academie Nederrijn e.V.
und des Instituts für niederrheinische Kulturgeschichte und Regionalentwicklung (InKuR), vol. 2023, no. 2 (35)
Additional file 1 of The impact of COVID-19 on pragmatic clinical trials: lessons learned from the NIH Health Care Systems Research Collaboratory
Creators: name: O’Brien, Emily C.
name: Sugarman, Jeremy
name: Weinfurt, Kevin P.
name: Larson, Eric B.
name: Heagerty, Patrick J.
name: Hernandez, Adrian F.
name: Curtis, Lesley H.
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Science Policy

description: Additional file 1. Questionnaire: Effect of COVID-19 on NIH Collaboratory Embedded Pragmatic Clinical Trials.
ARAB MAQOLLARI VA MATALLARINING SEMANTIK VA USLUBIY XUSUSIYATLARI
Creators: name: Abdullayeva, Shaxnoza
Publisher: name: Zenodo
Year: 2025

description: Mazkur maqolada arab maqollari va matallarining semantik va uslubiy xususiyatlari tadqiq qilingan. Arab tilida va boshqa tillarda maqol va matallarning funktsiyalarining ko’p turlari mavjud. Arab tilidagi maqollarni o’rganar ekanmiz, ular fikrlashni faollashtirish va ijodiy salohiyatni oshirishga qaratilgan muammoli ta’lim elementlarini o’z ichiga olgan o’quv funktsiyasiga ega ekanligini aniqladik.
Additional file 1 of Preoperative Education for Less Outpatient Pain after Surgery (PELOPS trial) in orthopedic patients—study protocol for a randomized controlled trial
Creators: name: Dziadzko, Mikhail
name: Bouteleux, Axelle
name: Minjard, Raphael
name: Harich, Jack
name: Joubert, Fanny
name: Pradat, Pierre
name: Pantel, Solene
name: Aubrun, Frederic
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Appendix 1. Comprehensive Anchoring Scale for Outpatient Orthopedic Surgery. Appendix 2. Scandalized script for educational intervention to be used with the scale (Additional file 1: Appendix 1)
Encouraging active transportation for children and finding sustainable solutions to school traffic problems in the District of West Vancouver : a case study of Gleneagles Elementary and West Bay Elementary : final report
Creators: name: Curtis, Emily
Publisher: name: The University of British Columbia
Year: 2015

description: The main objective of this report is to establish the problems that Gleneagles Elementary School and West Bay Elementary School are facing in terms of school traffic, and to provide recommendations and insight for those schools and others in the area on the ways that school traffic can be alleviated and active transportation can be encouraged. The information in this report as well as the final recommendations are intended to inform these two schools and the District of West Vancouver of the barriers schools can encounter and possible solutions in terms of school travel plans. It is important to note that the use of school bus programs has been excluded from this research due to the West Vancouver School Board illustrating the large barriers around school bus programs, such as finances. Barriers to Active Transportation Benefits to Active Transportation 1. Safety concerns surrounding active transportation 1. Improvements in physical health 2. Improvements in academic performance 2. Convenience of a vehicle 3. Sustainable Gleneagles Elementary School Problems: • Not enough children taking active transportation to/from school • Parents and guardians disobeying parking regulations • Not using pre-­‐existing programs Recommendations: • Utilization of the Spirit Trail (once installed) • Create a school brochure including information on the school’s parking regulations and programs in place, along with a URL to the Hub for Active School Travel website • Place cones and pylons in no-­‐stopping zones • Programs: park and walk program, walk/bike to school week program, classroom engagement West Bay Elementary School Problem: • Not enough children taking active transportation to/from school Recommendations: • Programs: park and walk program (possibly combined with a walking school bus program), walk/bike to school week program, classroom engagement • Advertise all of the above in the school brochure, along with a URL to the Hub for Active School Travel website
Additional file 1 of The relationships between school children's wellbeing, socio-economic disadvantage and after-school activities: a cross-sectional study
Creators: name: Kennewell, Eliza
name: Curtis, Rachel G.
name: Maher, Carol
name: Luddy, Samuel
name: Virgara, Rosa
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Computational Biology

description: Additional file 1: Supplementary Table 1. Odds ratios [and 95% confidence intervals] examining after-school activities and wellbeing among students from a low socioeconomic background.
title: Das Wohlbefinden von Kindern und Jugendlichen in Trennungsfamilien - Diskrepanzen zwischen Eltern- und Kinderperspektive
Creators: name: Brocker, Sven
Publisher: name: DuEPublico: Duisburg-Essen Publications online, University of Duisburg-Essen, Germany
Year: 2023
Subjects: subject: 300

description: In den letzten 50 Jahren hat das Wohlbefinden von Kindern und Jugendlichen in Trennungsfamilien in verschiedenen Forschungsdisziplinen große Beachtung gefunden. Dabei wurden beispielsweise elterliche Ressourcen, familiale Instabilität und die Rolle von Stress als theoretische Erklärungsansätze berücksichtigt (z.B. Amato, 2000; Fomby & Cherlin, 2007; Thomson & McLanahan, 2012). Tendenziell weisen Kinder, deren Eltern sich trennen, in verschiedenen Lebensbereichen ein verringertes Wohlbefinden auf (Härkönen et al., 2017; Zartler, 2021). Diesbezüglich basieren viele Forschungsergebnisse auf den Angaben der Eltern (Bornstein, 2014; Müller, 2019). Solche Proxy-Angaben werden methodisch jedoch kritisch gesehen, da sie zu verzerrten Ergebnissen führen können (Moore, 1988). Sollten Angaben von Eltern und Kindern in verschiedenen Bereichen systematisch voneinander abweichen, würde dies zu unterschiedlichen Studienergebnissen und Schlussfolgerungen führen. Trotz der damit verbundenen Relevanz für die Sozialpolitik und das Familienrecht findet sich in der Literatur jedoch nur selten eine Diskussion darüber, inwieweit die Perspektiven verschiedener Informanten miteinander übereinstimmen (z.B. Feldman et al., 1989; Sweeting, 2001). Obwohl unterschiedliche Disziplinen sich regelmäßig mit der Frage der Vergleichbarkeit von Angaben befassen, werden die Ergebnisse selten in Kombination betrachtet. Bereiche, die sich mit dieser allgemeinen Frage beschäftigen, umfassen zum Beispiel die Survey-Forschung, klinische Psychologie und Medizin (z.B. Cobb, 2018; De Los Reyes & Epkins, 2023; Eiser & Morse, 2001). Im Rahmen des Vortrags soll unter anderem methodisch erörtert werden, wie divergierende Sichtweisen vergleichend gegenübergestellt werden können. Dabei ist es wichtig, nicht nur zu fragen, ob Diskrepanzen existieren, sondern auch, wie groß diese sind. Da Wohlbefinden ein multidimensionales Konstrukt darstellt (Ruggeri et al., 2020), könnten beispielsweise Dimensionen mit einer stärkeren subjektiven Komponente auch größere Abweichungen zwischen Informanten aufweisen. Hierzu sollen erste Ergebnisse präsentiert werden. Da beispielsweise auch in angrenzenden Bereichen der Familienforschung mit Surveydaten mehrerer Informanten gearbeitet wird, profitiert möglicherweise auch diese Forschung von einem verbesserten Verständnis über die grundsätzliche Vergleichbarkeit von Angaben und den damit verbundenen Implikationen.
Imetelstat: First Approval
Creators: name: Keam, Susan J.
Publisher: name: Adis Journals
Year: 2024
Subjects: Medicine

description: Declarations
Funding The preparation of this review was not supported by any external funding.
Authorship and Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Susan J. Keam is a contracted employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to this article and are responsible for its content.
Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability not applicable
Additional information about this Adis Drug Review can be found here.
Abstract
Imetelstat (RYTELO™), an oligonucleotide telomerase inhibitor, is being developed by Geron Corporation for the treatment of myeloid hematologic malignancies. In June 2024, imetelstat was approved in the USA for use in adult patients with low- to intermediate-1 risk myelodysplastic syndromes (MDS) with transfusion-dependent anemia requiring 4 or more red blood cell units over 8 weeks who have not responded to or have lost response to or are ineligible for erythropoiesis-stimulating agents (ESA). This article summarizes the milestones in the development of imetelstat leading to this first approval for the treatment of adult patients with low- to intermediate-1 risk MDS with transfusion-dependent anemia.
© Springer Nature Switzerland AG 2024
Análisis de la deserción escolar en centros educativos oficiales, provincia de Veraguas, Panamá
Creators: name: Zamorano, Eduardo
name: Kristel, Cocherán
Publisher: name: Zenodo
Year: 2024

description: Se analiza las causas de la desercion escolar en los colegios oficiales de la provincia de Veraguas en la República de Panamá.
Written Interview for Python Software Engineer, Commercial Systems position at Canonical
Creators: name: Lutalo, Joseph Willrich
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 461299
subject: Software engineering not elsewhere classified
classificationCode: 461202
subject: Empirical software engineering
classificationCode: 461204
subject: Programming languages
classificationCode: 430303
subject: Biography

description: This is a Very Very Special Manuscript. It captures the gist of Lutalo Joseph Willrich's journey as a leading Software Engineer since his days as a kid, through high school and university, till now. It likewise brings to light his character, vision and plans in relation to his future career interests in the field. Particularly, this is JWL's formal application to join the terrific global team at Canonical, the makers of UBUNTU the popular Linux Operating System.
title: European Commission’s Plans for a Special Regulation of Plants Created by New Genomic Techniques
Creators: name: Kahrmann, Jens
name: Leggewie, Georg
Publisher: name: European Papers (www.europeanpapers.eu)
Year: 2024
Subjects: subject: environmental law
subject: genetic engineering
subject: new genomic techniques
subject: genome editing
subject: risk assessment
subject: precautionary principle

description: European Papers - A Journal on Law and Integration, 2024 9(1), 21-38
description: European Forum Insight of 15 April 2024
description: I. Introduction. - II. Context. - III. The draft regulation in detail. - III.1 Category 1 NGT plants. - III.2 Category 2 NGT plants. - III.3. Provisions for delegated and implementing acts as well as guidance material. - IV. Assessment of different scientific aspects in the regulation. - IV.1. Scientific reasoning of equivalence criteria as given in Annex I. - IV.2. Scientific reasoning of risk assessment criteria as given in Annex II. - V. Assessment of different legal aspects in the draft regulation. - V.1. Deliberate releases of cat 1 plants and committee procedure. - V.2 Precautionary principle. - V.3. Cartagena protocol. - v.4. Amendment of Annex I via delegated act. - VI. Ongoing discussion
description: This Insight explains in detail, yet easily understandable, the contents of the European Commission’s draft regulation on plants obtained by certain new genomic techniques and their food and feed. It critically comments on the underlying scientific considerations and discusses potential legal issues – the precautionary principle being one of them, though arguably not the most important one. Finally, the Insight summarizes the ongoing discussions and developments regarding the draft regulation. The Authors also hint at potential amendments, which might resolve some of the remaining problems.
The journey of the Constitution Express to Ottawa
Creators: name: Enns, Cassandra
Publisher: name: The University of British Columbia
Year: 2015

description: The Constitutional Express was a response to the federal governments proposed changes to the Canadian Constitution in 1980. As a result of the Union of B.C. Indian Chiefs analysis of these proposed changes, a state of emergency was declared and First Nations from across Canada mobilized to fight against their rights being extinguished. After protests nationally and internationally, Section 35 was added to the 1982 Canadian Constitution. Section 35 provides constitutional protection to the aboriginal and treaty rights of Aboriginal peoples in Canada. There is debate concerning whether or not Section 35 positively or negatively impacts Aboriginal Rights in Canada. Despite the controversy, the Constitution Express was a significant event because it was a political movement led by grassroots participants. However, current literature focuses on the result of the Constitution Express and the leader of the movement. There is a gap regarding the mobilization of this event and the journey. This paper aims to share the story of this grassroots movement by analyzing participant’s experiences and primary sources.
Additional file 2 of Preoperative Education for Less Outpatient Pain after Surgery (PELOPS trial) in orthopedic patients—study protocol for a randomized controlled trial
Creators: name: Dziadzko, Mikhail
name: Bouteleux, Axelle
name: Minjard, Raphael
name: Harich, Jack
name: Joubert, Fanny
name: Pradat, Pierre
name: Pantel, Solene
name: Aubrun, Frederic
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2: Appendix 3. PELOPS Carnet Patients 02
title: A Case Study of the CRASHOVERRIDE Malware, Its Effects and Possible Countermeasures
Creators: name: Samuel, Samuel
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2024

description: CRASHOVERRIDE is a modular malware tailor-made for electric grid Industrial Control System (ICS) equipment and was deployed by a group named ELECTRUM in a Ukrainian substation. The malware would launch a protocol exploit to flip breakers and would then wipe the system of ICS files. Finally, it would execute a Denial Of Service (DOS) attack on protective relays. In effect, months of damage and thousands out of power. However, due to oversights the malware only caused a brief power outage. Though the implications of the malware are cause for researching and implementing countermeasures against others to come. The CISA recommends several defenses implement additional ICS firewalls, enable Application Whitelisting, and start configuration/ patch management programs, etc.
Additional file 3 of Preoperative Education for Less Outpatient Pain after Surgery (PELOPS trial) in orthopedic patients—study protocol for a randomized controlled trial
Creators: name: Dziadzko, Mikhail
name: Bouteleux, Axelle
name: Minjard, Raphael
name: Harich, Jack
name: Joubert, Fanny
name: Pradat, Pierre
name: Pantel, Solene
name: Aubrun, Frederic
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 3: Appendix 4. PELOPS Carnet Patients 01
ЭКСТРЕННЫЕ СИТУАЦИИ В ПЕДИАТРИИ
Creators: name: Суюнов, Акрам
name: Тогаев, Бахром
name: Ахмедов, Ю.М.
Publisher: name: Zenodo
Year: 2024

description: В статье приведены данные об экстренных состояниях детей и алгоритм действия при данных ситуациях. Статья носит ознакомительный характер и помогает понять основы первой помощи и роль анестезиологическо-реаниматологической помощи.
Additional file 1 of Needle tract seeding and abdominal recurrence following pre-treatment biopsy of gastrointestinal stromal tumors (GIST): results of a systematic review
Creators: name: Jakob, Jens
name: Salameh, Rashad
name: Wichmann, David
name: Charalambous, Nicos
name: Zygmunt, Anne-Christine
name: Kreisel, Inga
name: Heinz, Judith
name: Ghadimi, Michael
name: Ronellenfitsch, Ulrich
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Additional file 1: The following supporting information can be downloaded: Prisma statements CRD42021170290.