Additional file 1 of LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease
Creators: name: Koper, Marta J.
name: Tomé, Sandra O.
name: Gawor, Klara
name: Belet, Annelies
name: Van Schoor, Evelien
name: Schaeverbeke, Jolien
name: Vandenberghe, Rik
name: Vandenbulcke, Mathieu
name: Ghebremedhin, Estifanos
name: Otto, Markus
name: von Arnim, Christine A. F.
name: Balusu, Sriram
name: Blaschko, Matthew B.
name: De Strooper, Bart
name: Thal, Dietmar Rudolf
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Table A1–Antibodies used in this study. Table A2–P values (a) and coefficient values (b) of correlation matrix comparing AβMTL phase, Braak NFT stage, LATE-NC stage, GVD stage, CDR score and neuronal density in the CA1-hippocampus (n = 230). Table A3–LATE-NC and Braak NFT contribute independently to GVD expansion. Linear regression model including GVD stage as dependent variable and LATE-NC and Braak NFT stages, age and sex as independent variables is displayed (n = 230). Table A4–LATE-NC and Braak NFT contribute to CA1-hippocampus neuronal density, albeit dependently from each other (a-b). Linear regression models including neuronal density as dependent variable and LATE-NC and Braak NFT stages, age and sex as independent variables are displayed (n = 64). Table A5–Only Braak NFT stage contributes to dementia ratings. Linear regression model including CDR score as dependent variable and LATE-NC and Braak NFT stages, age and sex as independent variables is displayed (n = 178). Table A6–LATE-NC stage impacts CDR global score, but not independently from Braak NFT stage. Linear regression model using LATE-NC stage, age and sex as independent variables and CDR global score as dependent variable (n = 178). Table A7–GVD stage contributes significantly to neuronal density. Linear regression model including neuronal density as dependent variable and GVD stage, age and sex as independent variables is displayed (n = 64). Table A8–AβMTL phase does not contributes independently to (a) GVD stage or (b) neuronal density when placed in a model with Braak NFT and LATE-NC stages. Linear regression models including GVD stage or neuronal density in the CA1 as dependent variables and Braak NFT stage, LATE-NC stage, age and sex asindependent variables are displayed (a, n = 230; b, n = 64). Table A9–P values (a) and coefficient values (b) of correlation matrix comparing AβMTL phase, Braak NFT stage, CDR score, neuronal density in the CA1-hippocampus, as well as severity of pTDP, pMLKL and pTau severity. N = 26 (non-AD = 9, ADTDP− = 8, ADTDP+ = 9). Figure A1–Age distribution in the cohorts used in this study a) n = 230, respective to Table 1 and b) n = 27, respective to Table 2. Figure A2–ADTDP+ cases have higher Braak NFT stage compared to ADTDP− cases (a), but they do not differ inage at death (b) and (c) percentage of positive cases for an APOE Ꜫ4 allele. (a-b) Unpaired t-tests and means withSEM (n = 27); (c) Chi-square, two-sided test.