cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A polarization filter at 1550 nm based on photonic crystal fiber with symmetry around gold-coated holes
Creators: name: Zha, Fengning
name: Li, Jinsong
name: Sun, Pengjie
name: Wang, Xiumin
Publisher: name: The Faculty of Fundamental Problems of Technology, Wrocław University of Science and Technology, Poland
Year: 2018
Subjects: photonic crystal fiber, polarization filter, finite element method, surface plasmon resonance

description: OPTICA APPLICATA; 04/2018; ISSN 1429-7507
Contrasting pathways of carbon sequestration in paddy and upland soils
Creators: name: Chen, Xiangbi
name: Hu, Yajun
name: Xia, Yinhang
name: Zheng, Shengmeng
name: Ma, Chong
name: Rui, Yichao
name: He, Hongbo
name: Huang, Daoyou
name: Zhang, Zhenhua
name: Ge, Tida
name: Wu, Jinshui
name: Guggenberger, Georg
name: Kuzyakov, Yakov
name: Su, Yirong
Publisher: name: Oxford [u.a.] : Wiley-Blackwell
Year: 2021
Subjects: subject: biomarker approach
subject: carbon sequestration
subject: climate zone
subject: lignin phenol
subject: microbial necromass
subject: paddy and upland
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie

description: Paddy soils make up the largest anthropogenic wetlands on earth, and are characterized by a prominent potential for organic carbon (C) sequestration. By quantifying the plant- and microbial-derived C in soils across four climate zones, we identified that organic C accrual is achieved via contrasting pathways in paddy and upland soils. Paddies are 39%–127% more efficient in soil organic C (SOC) sequestration than their adjacent upland counterparts, with greater differences in warmer than cooler climates. Upland soils are more replenished by microbial-derived C, whereas paddy soils are enriched with a greater proportion of plant-derived C, because of the retarded microbial decomposition under anaerobic conditions induced by the flooding of paddies. Under both land-use types, the maximal contribution of plant residues to SOC is at intermediate mean annual temperature (15–20°C), neutral soil (pH~7.3), and low clay/sand ratio. By contrast, high temperature (~24°C), low soil pH (~5), and large clay/sand ratio are favorable for strengthening the contribution of microbial necromass. The greater contribution of microbial necromass to SOC in waterlogged paddies in warmer climates is likely due to the fast anabolism from bacteria, whereas fungi are unlikely to be involved as they are aerobic. In the scenario of land-use conversion from paddy to upland, a total of 504 Tg C may be lost as CO2 from paddy soils (0–15 cm) solely in eastern China, with 90% released from the less protected plant-derived C. Hence, preserving paddy systems and other anthropogenic wetlands and increasing their C storage through sustainable management are critical for maintaining global soil C stock and mitigating climate change.
The long-term millimeter activity of active galactic nuclei
Creators: name: Trippe, S.
name: Krips, M.
name: Pietu, V.
name: Neri, R.
name: Winters, J. M.
name: Gueth, F.
name: Bremer, M.
name: Salome, P.
name: Moreno, R.
name: Boissier, J.
name: Fontani, F.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We analyze the long-term evolution of the fluxes of six active galactic nuclei (AGN) - 0923+392, 3C 111, 3C 273, 3C 345, 3C 454.3, and 3C 84 - in the frequency range 80-267 GHz using archival calibration data of the IRAM Plateau de Bure Interferometer. Our dataset spans a long timeline of ~14 years with 974-3027 flux measurements per source. We find strong (factors ~2-8) flux variability on timescales of years for all sources. The flux density distributions of five out of six sources show clear signatures of bi- or even multimodality. Our sources show mostly steep (alpha~0.5-1), variable spectral indices that indicate outflow dominated emission; the variability is most probably due to optical depth variations. The power spectra globally correspond to red-noise spectra with five sources being located between the cases of white and flicker noise and one source (3C 111) being closer to the case of random walk noise. For three sources the low-frequency ends of their power spectra appear to be upscaled in spectral power by factors ~2-3 with respect to the overall powerlaws. In two sources, 3C 454.3 and 3C 84, the 1.3-mm emission preceeds the 3-mm emission by ~55 and ~300 days, respectively, probably due to (combinations of) optical depth and emission region geometry effects. We conclude that the source emission cannot be described by uniform stochastic emission processes; instead, a distinction of "quiescent" and (maybe multiple) "flare" states of the source emission appears to be necessary.
description: 20 pages, 11 figures, 2 tables. Accepted by Astronomy + Astrophysics. Error in affiliation of F. Fontani corrected
Real-time optical demultiplexing with the chirped pulses
Creators: name: Li, Yan
name: Zhang, Xianting
name: Yuan, Jinhui
name: Kang, Zhe
name: Sang, Xinzhu
name: Kang, Shuai
name: Kang, Xue
name: Yan, Binbin
name: Wang, Kuiru
name: Yu, Chongxiu
Publisher: name: The Faculty of Fundamental Problems of Technology, Wrocław University of Science and Technology, Poland
Year: 2018
Subjects: linearly chirped pulse, parametric process, real-time optical demultiplexing

description: OPTICA APPLICATA; 04/2018; ISSN 1429-7507
Chaotic/Neutral: Comparing the Social Worlds and Psychological Utility of Fantasy Role-playing and Religion
Creators: name: Hearty, Brandon Daniel
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Fine Arts
subject: Religion--Philosophy of
subject: Social Structure and Development
subject: Psychology--Behavioral
subject: Role-playing
subject: Escapism
subject: Social Structure
subject: Printmaking
subject: Art

description: Chaotic/Neutral: Comparing the Social Worlds of and Psychological Utility of Fantasy Role-Playing and Religion provides a description of the conception and creation of artwork that proposes connections between the sociality of tabletop role-playing games and religious organizations as the subject of an autoethnographic approach to creative research. Evaluating the similarities between the subcultural groups of gaming and religion, I extract the strategies that result in their psychological utility. These methods are then inserted into a futurist narrative that addresses the shifting sociological landscape of the increasingly tech-oriented 21st century.
Band gap tuning in ferroelectric Bi4Ti3O12 by alloying LaTMO3 (TM = Ti, V, Cr, Mn, Co, Ni, and Al)
Creators: name: Choi, Woo Seok
name: Lee, Ho Nyung
Publisher: name: arXiv
Year: 2012
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We fabricated ferroelectric Bi4Ti3O12 (BiT) single crystalline thin films site-specifically substituted with LaTMO3 (TM = Al, Ti, V, Cr, Mn, Co, and Ni) on SrTiO3 substrates by pulsed laser epitaxy. When transition metals are incorporated into a certain site of the BiT, some of BiT-LaTMO3 showed a substantially decreased band gap, coming from the additional optical transition between oxygen 2p and TM 3d states. Specifically, all alloys with Mott insulators revealed a possibility of band gap reduction. Among them, BiT-LaCoO3 showed the largest band gap reduction by ~1 eV, positioning itself as a promising material for highly efficient opto-electronic devices.
Investigation of hybrid Ge QDs/Si nanowires solar cell with improvement in cell efficiency
Creators: name: Olyaee, Saeed
name: Farhadipour, Farzad
Publisher: name: The Faculty of Fundamental Problems of Technology, Wrocław University of Science and Technology, Poland
Year: 2018
Subjects: nanowire, absorption, FDTD, hybrid structure, thin-film, cylindrical quantum dots

description: OPTICA APPLICATA; 04/2018; ISSN 1429-7507
Geomechanical Properties of the Montney and Sulphur Mountain Formations
Creators: name: McKean, Scott Harold
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Applied Mechanics
subject: Energy
subject: Engineering--Civil
subject: hydraulic fracturing
subject: triaxial testing
subject: ultrasonic pulse transmission
subject: heterogeneity
subject: Anisotropy
subject: Failure
subject: Brazilian testing

description: Accurate modelling of hydraulic fracturing is critical for improving the cost efficiency and societal acceptance of unconventional hydrocarbon exploitation. This thesis investigates the geomechanical inputs required to improve hydraulic fracturing using X-Ray fluorescence, helium pyncnometry, microhardness, point load strength testing, unconfined compressive strength testing, Brazilian testing, multi-stage triaxial testing, and ultrasonic pulse transmission. The Montney Formation and its outcrop equivalent, the Sulphur Mountain Formation, are studied. Static and dynamic experimental results are interpreted and compared using a transversely isotropic framework. The Sulphur Mountain samples were more brittle and heterogeneous than Montney samples, which were harder and failed in a more stable fashion. Heterogeneity was a stronger control on failure, strength, and elastic constants than anisotropy caused by layering. Complex failure mechanisms were observed in Brazilian and triaxial tests and yielded insights into fracture propagation processes, inhomogeneity, and stress concentrations.
Methanotrophs: Discoveries, Environmental Relevance, and a Perspective on Current and Future Applications
Creators: name: Guerrero-Cruz, Simon
name: Vaksmaa, Annika
name: Horn, Marcus A.
name: Niemann, Helge
name: Pijuan, Maite
name: Ho, Adrian
Publisher: name: Lausanne : Frontiers Media
Year: 2021
Subjects: subject: anaerobic
subject: application
subject: circular economy
subject: climate change
subject: methane
subject: methanotrophy
subject: microbial ecology
subject: resource recovery
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie

description: Methane is the final product of the anaerobic decomposition of organic matter. The conversion of organic matter to methane (methanogenesis) as a mechanism for energy conservation is exclusively attributed to the archaeal domain. Methane is oxidized by methanotrophic microorganisms using oxygen or alternative terminal electron acceptors. Aerobic methanotrophic bacteria belong to the phyla Proteobacteria and Verrucomicrobia, while anaerobic methane oxidation is also mediated by more recently discovered anaerobic methanotrophs with representatives in both the bacteria and the archaea domains. The anaerobic oxidation of methane is coupled to the reduction of nitrate, nitrite, iron, manganese, sulfate, and organic electron acceptors (e.g., humic substances) as terminal electron acceptors. This review highlights the relevance of methanotrophy in natural and anthropogenically influenced ecosystems, emphasizing the environmental conditions, distribution, function, co-existence, interactions, and the availability of electron acceptors that likely play a key role in regulating their function. A systematic overview of key aspects of ecology, physiology, metabolism, and genomics is crucial to understand the contribution of methanotrophs in the mitigation of methane efflux to the atmosphere. We give significance to the processes under microaerophilic and anaerobic conditions for both aerobic and anaerobic methane oxidizers. In the context of anthropogenically influenced ecosystems, we emphasize the current and potential future applications of methanotrophs from two different angles, namely methane mitigation in wastewater treatment through the application of anaerobic methanotrophs, and the biotechnological applications of aerobic methanotrophs in resource recovery from methane waste streams. Finally, we identify knowledge gaps that may lead to opportunities to harness further the biotechnological benefits of methanotrophs in methane mitigation and for the production of valuable bioproducts enabling a bio-based and circular economy.
Biadjointness in cyclic Khovanov-Lauda-Rouquier Algebras
Creators: name: Kashiwara, Masaki
Publisher: name: arXiv
Year: 2011
Subjects: subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 05E10, 16G99, 81R10

description: We prove that the simple root functors E and F appearing in the categorification of irreducible highest weight modules of quantum groups via cyclotomic Khovanov-Lauda-Rouquier algebras is a biadjoint pair.
description: 26pages
ANÁLISE DA MORTALIDADE POR CÂNCER DE PRÓSTATA NA REGIÃO NORDESTE BRASILEIRA
Creators: name: Da Silva, Maria Fernanda Bandeira
Publisher: name: Zenodo
Year: 2023
Subjects: Neoplasias da próstata; Mortalidade; Avaliação em Saúde

description: O câncer de próstata é um dos principais tipos de cânceres que são registrados em indivíduos do sexo masculino. Quando diagnosticado precocemente, pode aumentar a sobrevida do paciente reduzindo a probabilidade de óbito por esta causa. Objetivo: analisar o perfil da mortalidade por câncer de próstata na região nordeste do Brasil. Metodologia: estudo descritivo, realizado através de dados do Atlas de Mortalidade por Câncer do Instituto Nacional do Câncer, extraídas por meio de tabulação do aplicativo, disponível no período de 2009 a 2018. Os dados foram organizados em planilhas do Microsoft Excel 2016 e analisados à luz da literatura pertinente. Considerando que foram utilizados dados secundários, dispensou-se a submissão à Comitê de ética em Pesquisa. Resultados: identificou-se que foram registrados 38.614 casos de óbito por câncer de próstata, com tendência de alta ao longo do período e que os estados Bahia, Pernambuco e Ceará apresentaram os maiores valores. Em relação à taxa de
 mortalidade bruta, o Nordeste teve uma variação de 12,7 a 15,7 óbitos por 100.000 habitantes. Os homens com idade superior a 60 anos representaram 95,3% dos óbitos. Conclusão: conclui-se que a região nordeste apresentou mortalidade por câncer de próstata com tendência de alta ao longo do período estudado.
An ethico-legal framework for social data science
Creators: name: Forgó, Nikolaus
name: Hänold, Stefanie
name: Van Den Hoven, Jeroen
name: Krügel, Tina
name: Lishchuk, Iryna
name: Mahieu, René
name: Monreale, Anna
name: Pedreschi, Dino
name: Pratesi, Francesca
name: Van Putten, David
Publisher: name: Cham, Switzerland : Springer International Publishing
Year: 2021
Subjects: subject: Ethical data science
subject: Legal data science
subject: Research infrastructure
subject: Dewey Decimal Classification::000 | Allgemeines, Wissenschaft::000 | Informatik, Wissen, Systeme::004 | Informatik

description: This paper presents a framework for research infrastructures enabling ethically sensitive and legally compliant data science in Europe. Our goal is to describe how to design and implement an open platform for big data social science, including, in particular, personal data. To this end, we discuss a number of infrastructural, organizational and methodological principles to be developed for a concrete implementation. These include not only systematically tools and methodologies that effectively enable both the empirical evaluation of the privacy risk and data transformations by using privacy-preserving approaches, but also the development of training materials (a massive open online course) and organizational instruments based on legal and ethical principles. This paper provides, by way of example, the implementation that was adopted within the context of the SoBigData Research Infrastructure.
Varying the sustained release of BMP-2 from chitosan nanogel-functionalized polycaprolactone fiber mats by different polycaprolactone surface modifications
Creators: name: Sundermann, Julius
name: Oehmichen, Sarah
name: Sydow, Steffen
name: Burmeister, Laura
name: Quaas, Bastian
name: Hänsch, Robert
name: Rinas, Ursula
name: Hoffmann, Andrea
name: Menzel, Henning
name: Bunjes, Heike
Publisher: name: New York, NY [u.a.] : Wiley
Year: 2021
Subjects: subject: BMP-2
subject: chitosan coating
subject: growth factor delivery
subject: PCL fiber scaffold
subject: surface modification
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie

description: Polycaprolactone (PCL) fiber mats with different surface modifications were functionalized with a chitosan nanogel coating to attach the growth factor human bone morphogenetic protein 2 (BMP-2). Three different hydrophilic surface modifications were compared with regard to the binding and in vitro release of BMP-2. The type of surface modification and the specific surface area derived from the fiber thickness had an important influence on the degree of protein loading. Coating the PCL fibers with polydopamine resulted in the binding of the largest BMP-2 quantity per surface area. However, most of the binding was irreversible over the investigated period of time, causing a low release in vitro. PCL fiber mats with a chitosan-graft-PCL coating and an additional alginate layer, as well as PCL fiber mats with an air plasma surface modification boundless BMP-2, but the immobilized protein could almost completely be released. With polydopamine and plasma modifications as well as with unmodified PCL, high amounts of BMP-2 could also be attached directly to the surface. Integration of BMP-2 into the chitosan nanogel functionalization considerably increased binding on all hydrophilized surfaces and resulted in a sustained release with an initial burst release of BMP-2 without detectable loss of bioactivity in vitro.
VERITAS Observations of the BL Lac Object PG 1553+113 Between May 2010 and May 2011
Creators: name: Orr, Matthew
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: VERITAS, an array of imaging atmospheric-Cherenkov telescopes, studies blazars in the energy range between ~100 GeV and ~30 TeV. With its excellent sensitivity at these energies, and ever-deepening source exposures, VERITAS is in a position to probe distant blazars for clear absorption signatures in their very-high-energy gamma-ray spectra due to interactions with the extragalactic background light (EBL). We discuss results from recent VERITAS observations of PG 1553+113 (z > 0.4) which have resulted in the most significant very-high-energy detection ever obtained for this source. The most recent VERITAS spectral measurements are used to place an upper limit on the source redshift of z < 0.5 at the 95% confidence level. Also discussed are the prospects of using these observations, along with those of other hard- spectrum blazars, to place constraints on the EBL.
description: 4 pages, to appear in proceedings of the 32nd ICRC, Beijing, China
The Role of Microglial P2X7 Receptor Phosphorylation in Neuropathic Pain
Creators: name: Pilapil, Alexandra
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Neuroscience
subject: Neuropathic Pain
subject: Chronic Pain
subject: Microglia
subject: Purinergic Receptors
subject: P2X7 Receptors
subject: Spinal Cord

description: Neuropathic pain is a debilitating chronic pain condition that can arise because of injury to a peripheral nerve. The lack of effective therapies for neuropathic pain demands a better understanding of the underlying mechanisms. Converging evidence suggests that neuropathic pain is caused by aberrant cellular and molecular changes within the central nervous system. Microglia and P2X7 receptors (P2X7Rs) are spinal targets implicated in neuropathic pain, but the core mechanisms that modulate microglial P2X7R activity remain obscure. We identified Y382-384 within the P2X7R C-terminal domain as a putative phosphorylation site that underlies nerve injury-induced mechanical allodynia in a sex-dependent mechanism. Thus, site-specific tyrosine phosphorylation of P2X7R in microglia is a novel spinal determinant involved in neuropathic pain for male animals. The findings of this study provide evidence for microglial-mediated sex differences in neuropathic pain, which further reinforces the importance of including male and female subjects in preclinical pain research.
Facile Synthesis of a Croconaine-Based Nanoformulation for Optoacoustic Imaging and Photothermal Therapy
Creators: name: Liu, Nian
name: O'Connor, Patrick
name: Gujrati, Vipul
name: Gorpas, Dimitris
name: Glasl, Sarah
name: Blutke, Andreas
name: Walch, Axel
name: Kleigrewe, Karin
name: Sattler, Michael
name: Plettenburg, Oliver
name: Ntziachristos, Vasilis
Publisher: name: Weinheim : Wiley-VCH
Year: 2021
Subjects: subject: croconaine
subject: nanoparticles
subject: optoacoustics
subject: photothermal therapy
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit

description: Near-infrared (NIR) light absorbing theranostic agents can integrate optoacoustic imaging and photothermal therapy for effective personalized precision medicine. However, most of these agents face the challenges of unstable optical properties, material-associated toxicity, and nonbiodegradability, all of which limit their biomedical application. Several croconaine-based organic agents able to overcome some of these limitations have been recently reported, but these suffer from complicated multistep synthesis protocols. Herein, the use of CR760, a croconaine dye with excellent optical properties, is reported for nanoparticle formulation and subsequent optoacoustic imaging and photothermal therapy. Importantly, CR760 can be conveniently prepared in a single step from commercially available materials. Furthermore, CR760 can be covalently attached, via a polyethylene glycol linker, to the αvβ3 integrin ligand c(RGDyC), resulting in self-assembled nanoparticles (NPs) with cancer-targeting capability. Such CR760RGD-NPs exhibit strong NIR absorption, high photostability, high optoacoustic generation efficiency, and active tumor-targeting, making them ideal candidates for optoacoustic imaging. Due to favorable electron transfer, CR760RGD-NPs display a 45.37% photothermal conversion efficiency thereby rendering them additionally useful for photothermal therapy. Targeted tumor elimination, biosafety, and biocompatibility are demonstrated in a 4T1 murine breast tumor model. This work points to the use of CR760RGD-NPs as a promising nanoagent for NIR-based cancer phototheranostics.
Finite element discretization of a biological network formation system: a preliminary study
Creators: name: Astuto, Clarissa
name: Boffi, Daniele
name: Credali, Fabio
Publisher: name: arXiv
Year: 2023
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 35Axx 35Exx 35G20 35G31 34Axx

description: A finite element discretization is developed for the Cai-Hu model, describing the formation of biological networks. The model consists of a non linear elliptic equation for the pressure $p$ and a non linear reaction-diffusion equation for the conductivity tensor $\mathbb{C}$. The problem requires high resolution due to the presence of multiple scales, the stiffness in all its components and the non linearities. We propose a low order finite element discretization in space coupled with a semi-implicit time advancing scheme. The code is {verified} with several numerical tests performed with various choices for the parameters involved in the system. In absence of the exact solution, we apply Richardson extrapolation technique to estimate the order of the method.
description: 11 pages, 3 figures, 18 plots, 2 tables
Ewald sum for hydrodynamic interactions with periodicity in two dimensions
Creators: name: Bleibel, J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We carry out the Ewald summation for the Rotne-Prager-Yamakawa mobility tensor, the Oseen mobility tensor and further variations of both, relevant for the hydrodynamic interactions in colloidal suspensions, where all interacting particles are within a single plane, i.e., adsorbed at a fluid interface or other quasi two-dimensional systems. We use the Poisson summation formula for systems periodic in two dimensions and finite in the third dimension in order to obtain simple formulae for applications, such as molecular dynamics or Brownian dynamics simulations. We show, that for such systems, as soon as noise is taken into account, a commonly used approximate three-dimensional Ewald summation leads to a spurious system size dependence, which may considerably affect the interpretation of simulation results and will be cured within our approach. Additionally, the resulting formulae are found to be computationally much less expensive than the approximate three-dimensional Ewald summation.
description: 24 pages, 3 figures
JUSTNORTH EU Integrated Arctic Policy Analysis Report and Recommendations. Key Challenge 10: EU Arctic Governance
Creators: name: JUSTNORTH
Publisher: name: Zenodo
Year: 2023
Subjects: Arctic economies, Economic development, Sustainable development, Values

description: Key Recommendations:
(R1) Ensure that the potential impacts of EU policies and regulations on the Arctic region are systematically addressed both during the development phase and during implementation 
(R2) Allocate support towards resources and capacity-building for Arctic actors to effectively and adequately participate in EU governance
(R3) Implement a more sustained and coordinated EU participation in the Arctic Council
Recruitment of phospholipase Cγ1 to the nonstructural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation
Creators: name: Samarina, Naira
name: Ssebyatika, George
name: Tikla, Tanvi
name: Waldmann, Ja-Yun
name: Abere, Bizunesh
name: Nanna, Vittoria
name: Marasco, Michelangelo
name: Carlomagno, Teresa
name: Krey, Thomas
name: Schulz, Thomas F.
Publisher: name: Lawrence, Kan. : PLoS
Year: 2021
Subjects: subject: HEK293 Cells
subject: Herpesviridae Infections
subject: Herpesvirus 8, Human
subject: Humans
subject: Phospholipase C gamma
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit

description: Kaposi Sarcoma-associated herpesvirus (KSHV) causes three human malignancies, Kaposi Sarcoma (KS), Primary Effusion Lymphoma (PEL) and the plasma cell variant of multicentric Castleman’s Disease (MCD), as well as an inflammatory cytokine syndrome (KICS). Its non-structural membrane protein, pK15, is among a limited set of viral proteins expressed in KSHV-infected KS tumor cells. Following its phosphorylation by Src family tyrosine kinases, pK15 recruits phospholipase C gamma 1 (PLCγ1) to activate downstream signaling cascades such as the MEK/ERK, NFkB and PI3K pathway, and thereby contributes to the increased proliferation and migration as well as the spindle cell morphology of KSHV-infected endothelial cells. Here, we show that a phosphorylated Y481EEVL motif in pK15 preferentially binds into the PLCγ1 C-terminal SH2 domain (cSH2), which is involved in conformational changes occurring during the activation of PLCγ1 by receptor tyrosine kinases. We determined the crystal structure of a pK15 12mer peptide containing the phosphorylated pK15 Y481EEVL motif in complex with a shortened PLCγ1 tandem SH2 (tSH2) domain. This structure demonstrates that the pK15 peptide binds to the PLCγ1 cSH2 domain in a position that is normally occupied by the linker region connecting the PLCγ1 cSH2 and SH3 domains. We also show that longer pK15 peptides containing the phosphorylated pK15 Y481EEVL motif can increase the Src-mediated phosphorylation of the PLCγ1 tSH2 region in vitro. This pK15-induced increase in Src-mediated phosphorylation of PLCγ1 can be inhibited with the small pK15-derived peptide which occupies the PLCγ1 cSH2 domain. Our findings thus suggest that pK15 may act as a scaffold protein to promote PLCγ1 activation in a manner similar to the cellular scaffold protein SLP-76, which has been shown to promote PLCγ1 activation in the context of T-cell receptor signaling. Reminiscent of its positional homologue in Epstein-Barr Virus, LMP2A, pK15 may therefore mimic aspects of antigen-receptor signaling. Our findings also suggest that it may be possible to inhibit the recruitment and activation of PLCγ1 pharmacologically.
Hypodifferentials of nonsmooth convex functions and their applications to nonsmooth convex optimization
Creators: name: Dolgopolik, M. V.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: A hypodifferential is a compact family of affine mappings that defines a local max-type approximation of a nonsmooth convex function. We present a general theory of hypodifferentials of nonsmooth convex functions defined on a Banach space. In particular, we provide complete characterizations of hypodifferentiability and hypodifferentials of nonsmooth convex functions, derive calculus rules for hypodifferentials, and study the Lipschitz continuity/Lipschitz approximation property of hypodifferentials that can be viewed as a natural extension of the Lipschitz continuity of the gradient to the general nonsmooth setting. As an application of our theoretical results, we study the rate of convergence of several versions of the method of hypodifferential descent for nonsmooth convex optimization and present an accelerated version of this method having the faster rater of convergence $\mathcal{O}(1/k^2)$.
Effect of a non-volatile cosolvent on crack pattern induced by desiccation of a colloidal gel
Creators: name: Boulogne, François
name: Pauchard, Ludovic
name: Giorgiutti-Dauphiné, Frédérique
Publisher: name: arXiv
Year: 2012
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Consolidation of colloidal gels results in enormous stresses that are usually released in the formation of undesirable cracks. The capacity of a gel network to crack during drying depends on the existence and significance of a pressure gradient in the pore liquid; in addition it depends on the way the gel relaxes the resulting drying stresses. In this paper the effect of a binary mixture of solvents saturating the gel network on the crack patterns formation is investigated. Indeed, incorporation of a small quantity of non-volatile cosolvent, i.e. glycerol, inhibits drying-induced cracks; moreover addition of a concentration greater than 10% to a colloidal dispersion leads to a crack free coating in room conditions. Mass variation with time reveals that both evaporation rate and cracking time are not affected by glycerol, in the range of added glycerol contents studied. In addition measurements of mechanical properties show that the elastic modulus is reduced with glycerol content. The decrease of the number of cracks with the glycerol content is related to the flattening of the pressure gradient in the pore liquid. The mechanism is shown to be due to the combination of two processes: flow driven by the pressure gradient and diffusion mechanisms in accordance with Scherer work (1989).
description: Accepted in Soft Matter
Tamed: Hair and Female Subjectivity
Creators: name: Lin, Ziya
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Fine Arts
subject: discrimination against Chinese women
subject: “leftover women”
subject: Western drawing methods
subject: Chinese line art
subject: installation art

description: This thesis explores the continued discrimination against women in China today, and examines my art research throughout the study of the Master of Fine Arts degree at University of Calgary. Although, since 1949, Mao Zedong had proclaimed that “women hold up half of the sky,” in fact societal pressure on women to conform is so great that even women’s association have co-opted the derogatory term “leftover women” (shengnü) for defining the unmarried women. Sociologist Leta Hong Fincher has studied this phenomenon and her results are the scientific foundation for my artistic exploration. Through using the image of hair as a metaphor, my art practice concerns the social and cultural containment imposed on women, revealing the dilemmas and obstacles that women experience in their lives. Technically, I have investigated ways of coalescing Western drawing methods and Chinese line art together, and have reoriented the traditional Chinese scrolls into installation art.
Voices: Developing a Studio-based Pedagogy for Those Living in the Margins of Society Due to Poverty
Creators: name: Shaikh, Linda Diane Holaday
Publisher: name: Graduate Studies
Year: 2015
Subjects: subject: Education--Teacher Training
subject: Creative development
subject: Educator training
subject: Marginalized populations
subject: creative studio
subject: Pedagogy
subject: Adult education

description: In effort to find more effective ways for facilitators to help a marginalized population, I brought a studio into a traditional educational context at a community health and education centre. The studio offered space, time and materials for participants to reflect on and connect to the lessons presented in the program. The studio offered expression in any of the languages of learning, including the poetic, scientific, mathematical or verbal. In co-researching this project, the participants and I assessed the effectiveness of the studio and its facilitators. We found the studio to be vital to learning and communication, creative and mental growth. The participants found their unique voice through the work, and then combined those voices to bring forth their expertise. We presented a strong argument for the inclusion of studio in an educational context. As I present their argument in this paper, encouraging the reader to listen, their voices are further validated. They have the opportunity to be included in society's conversations and take a responsible role.
title: A Survey of Burnout Among Dental Hygiene Educators
Creators: name: Ricks, Sandra Boggs
Publisher: name: Old Dominion University Libraries
Year: 1984

description: A survey was conducted on 159 full-time dental hygiene educators in order to collect data on job satisfaction, morale, and perceived institutional/program effectiveness. Educators were chosen for the study by cluster sampling from two- and four-year accredited dental hygiene programs in the United States. The programs were selected at random from stratified groups according to type of institutional setting. Participants were asked to complete a questionnaire which contained four major sections: demographic data, job satisfaction, institutional/program effectiveness, and feelings related to their position. Findings were analyzed utilizing contingency tables and Chi-Square analysis. No attempt was made to establish a cause and effect relationship between any of the variables present. Data analysis suggests that characteristics of burnout are evident in the profession of dental hygiene educators. Findings suggest that a significant relationship exists between institutional setting type and aspects of job satisfaction as well as institutional effectiveness and aspects of job satisfaction.
Passenger - for string quartet
Creators: name: Santa Ana, Alfredo
Publisher: name: University of British Columbia
Year: 2010

description: Passenger is a multi-version musical composition of approximately 40 minutes in length scored for string quartet. The formal design of the piece involves reconfiguring its large-scale form each time it is performed. During any given performance the piece is an uninterrupted and continuous flow of music, but its distinct seven-segment structure allows a reordering of the music’s segments in a chosen sequence where each segment is played once, and only once, starting with a fixed opening segment. Once the order of the segments is selected each segment connects to the next through a series of overlapping transitions that present an unbroken listening experience. The total number of possible variations for Passenger is 720. Comparatively, each possible rendering of the piece offers a wide degree of change in order to demonstrate how impermanent large-scale form operates as a compositional technique. Its changing structure was created with the intention of promoting a variety of readings of the composition’s musical content by altering the chronological placement of large sections of music. Subsequent listening experiences will explore alternative pathways with which to cover familiar musical material and contribute to the music’s overall interpretation. The goal of this project is to rethink the role of form, and to use it as an agent of change capable of generating new and expressive methods of music making and listening.
Discovery and characterization of a new zinc-bacteriochlorophyll biosynthetic pathway and photosystem in a magnesium-chelatase mutant
Creators: name: Jaschke, Paul Richard Ayre
Publisher: name: University of British Columbia
Year: 2010

description: Porphyrins, for example heme and chlorophyll, are vital to biological processes such as respiration and photosynthesis. Both cofactors are synthesized through a common pathway to protoporphyrin IX (PPIX) which then branches: Fe²⁺ chelation into the macrocycle by ferrochelatase results in heme formation; by contrast, Mg²⁺ addition by Mg-chelatase commits the porphyrin to (bacterio)chlorophyll synthesis. The purple bacterium Rhodobacter sphaeroides is a model for bacteriochlorophyll a (BChl) biosynthesis and type-2 reaction center (RC) structure and function. While studying RC protein assembly it was discovered that a bchD (Mg-chelatase) mutant did not produce BChl as wild-type (wt) cells do, but instead produced small quantities of an alternative BChl in which Mg²⁺ was substituted by Zn²⁺. Zn-BChl α has been found in only one other organism before, the related acidophilic purple phototrophic bacterium Acidiphilium rubrum. The overall objectives of this thesis were two-fold: (1) to elucidate the Zn-BChl biosynthetic pathway; and (2) to utilize this biosynthesis as a tool to probe aspects of photosynthetic apparatus function. The biosynthetic pathway of Zn-BChl in the bchD mutant was found to begin at ferrochelatase, which efficiently chelated Zn²⁺ into PPIX. The resultant Zn-PPIX was utilized by the BChl-biosynthetic pathway, with metabolites early in the pathway accumulating, but with low Zn-BChl levels. Two novel intermediates I described, protoporphyrin IX monomethyl ester and divinyl-protochlorophyllide, contained Zn²⁺ instead of Mg²⁺. The demonstrated Zn-BChl biosynthetic pathway is a new way to make BChl and facilitates the further engineering of alternate forms of (Zn-)BChl. The RC in the bchD mutant (Zn-RC) was found to bind six Zn-BChls, instead of the four Mg-BChls and two bacteriopheophytins of the WT-RC. Spectroscopic examination showed that electron transfer (ET) in the Zn-RC occurs at approximately the same rate as in the WT-RC, despite substitution of Zn-BChl for bacteriopheophytin α. We showed preservation of ET was due to the unusual tetracoordination state of the Zn-BChls in the bacteriopheophytin site. This discovery allows refinement of ET rules within pigment-protein complexes by showing that the coordination state and conformation of cofactors can have an equally important role as the protein.
Knowledge Hub Live day @UAntwerpen (20231123): Open Data
Creators: name: Vermeyen, Maarten
name: Berckmans, Jolien
name: Peeters, Jef
name: Benramdane, Siham
name: Nasser, Dunya
Publisher: name: Zenodo
Year: 2023

description: On this Live day, we tackled and discussed the complexity of Open Data.
We had two presentations, one on Open Data vs. GDPR from Jolien Berckmans, followed by a presentation from Jef Peeters on Restricted Access Data. Both presentation can be found as files. 
Building on this, we tackled two use cases (created by Maarten Vermeyen, Siham Benramdane, Jef Peeters and Dunya Nasser) discussing the diversity in the Reuse of Data and Sharing of Data. 
These use cases, the attachments to these cases and the presentation guiding the discussion of these cases can be found as files.
Process Channels: A New Layer for Process Enactment Based on Blockchain State Channels
Creators: name: Stiehle, Fabian
name: Weber, Ingo
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cryptography and Security (cs.CR)
subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: For the enactment of inter-organizational business processes, blockchain can guarantee the enforcement of process models and the integrity of execution traces. However, existing solutions come with downsides regarding throughput scalability, latency, and suboptimal tradeoffs between confidentiality and transparency. To address these issues, we propose to change the foundation of blockchain-based business process execution: from on-chain smart contracts to state channels, an overlay network on top of a blockchain. State channels allow conducting most transactions off-chain while mostly retaining the core security properties offered by blockchain. Our proposal, process channels, is a model-driven approach to enacting processes on state channels, with the aim to retain the desired blockchain properties while reducing the on-chain footprint as much as possible. We here focus on the principled approach of state channels as a platform, to enable manifold future optimizations in various directions, like latency and confidentiality. We implement our approach prototypical and evaluate it both qualitatively (w.r.t. assumptions and guarantees) and quantitatively (w.r.t. correctness and gas cost). In short, while the initial deployment effort is higher with state channels, it typically pays off after a few process instances; and as long as the new assumptions hold, so do the guarantees.
description: Accepted at BPM 2023
Morphosyntactic local variation in Chaga: Group-internal variation and atypical features in Eastern Bantu
Creators: name: Shinagawa, Daisuke
Publisher: name: Zenodo
Year: 2021
Subjects: Bantu, Chaga, morphosyntax, TAM, chain shift, post-nasal trilling, negation particles

description: This presentation aims to showcase the structural microvariation of typologically uncommon features observed in the Chaga group of languages (E60 in the Guthrie's code) spoken on the slope area of Mt. Kilimanjaro. The features discussed include i) geographical distribution of TAM markers and their chain shift relations, ii) post nasal trilling of voiced stops, iii) clause-final negation particles and the process of their historical development.
Index computation for 3d Chern-Simons matter theory: test of Seiberg-like duality
Creators: name: Hwang, Chiung
name: Kim, Hyungchul
name: Park, Kyung-Jae
name: Park, Jaemo
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We work out the superconformal index for N=2 supersymmetric Chern-Simons matter theories exhibiting Seiberg-like dualities proposed by Giveon and Kutasov. We consider $U(N)/Sp(2N)/O(N)$ gauge theories of QCD type and find the perfect agreements for proposed dual pairs.
description: References added
Catechin and Curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: Insights from Computational studies
Creators: name: Dandapat, Jagneshwar
name: Atala Jena
name: Kanungo, Namrata
name: Chainy, Gagan Bihari
Publisher: name: figshare
Year: 2020
Subjects: subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: Computational Biology
subject: 60109 Proteomics and Intermolecular Interactions (excl. Medical Proteomics)
subject: FOS: Biological sciences
subject: Structural Biology
subject: 60112 Structural Biology (incl. Macromolecular Modelling)

description: The recent outbreak of the coronavirus (2019n-CoV) is an unprecedented threat for human health throughout the globe. In this regards development of a suitable intervention is the need of the hour. The viral spike protein (S-Protein) and the cognate host cell receptor ACE2 can prove to be effective. Here, through computational approaches we have reported two polyphenols, Catechin and Curcumin which have dual binding affinity i.e both the molecule binds to viral S-protein and as well as ACE2. Catechin binds with S-protein and ACE2 with binding energy of -10.5 Kcal/mol and -8.9 Kcal/mol, respectively. Catechin binds with a greater affinty than that of curcumin which has a binding energy of -7.9Kcal/mol and - 7.8Kcal/mol for S-protein and ACE2, respectively. While curcumin gets bound directly to receptor binding domain (RBD) of viral S-protein, catechin binds to near proximity of RBD sequence of S-protein. Molecular simulation study demonstrates that curcumin directly binds with RBD site of S-protein during 40-100ns. In contrast, catechin binds with S-protein near the RBD site and causes fluctuation in the amino acids present in the RBD and it’s near proximity. In conclusion, this computational study for the first time predicts the possibility of above two polyphenols, for therapeutic/preventive intervention
Dairy Calf and Heifer (Holstein, Bos taurus) Management Practices in Western Canada: Current Status and Impacts on Animal Welfare
Creators: name: Borges Bond, Guilherme
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Animal Culture and Nutrition
subject: Veterinary Science
subject: Health
subject: Behaviour
subject: Growth
subject: cattle

description: Calves are the future of the dairy enterprise but their management is often neglected. The objectives of this thesis were: 1) to describe young stock management practices in commercial dairy farms and the compliance of producers with Canadian guidelines and; 2) to analyse the effect of management practices on calf performance, health and welfare. Eighty-two farms were visited in Alberta and British Columbia (BC), Canada. Producers completed a survey about their pre-weaned calf management practices and their awareness and use of the Code of Practice for the Care and Handling of Dairy Cattle (COP, n = 67 farms). Compliance with calf management practices in the COP was moderate and did not change whether producers were aware or not aware of the COP. Few producers changed practices as a result of the COP. The second objective was divided in two sections. The first section, comprised of 2 cross sectional studies, body weight (BW) was estimated for all pre-weaned calves (0 to 8 weeks) and heifers (12 to 15 months, BC farms only). Animals were observed for signs of nasal discharge or diarrhea and assessed for failure of passive transfer of immunity (FPT). Calves fed more than 5L of milk by bottle and introduced to water between 4 and 8 weeks of age had higher BW. Feeding less milk and offering colostrum replacer were associated with increased odds of disease and FPT. Higher heifer BW was associated with higher calf BW in the same farm. In the second section, a study on the effects of milk allowances on water drinking behaviour of dairy calves, animals were fed milk replacer either ad libitum or at 10% BW with free access to water and dry feed. Calves fed restrictively drank more water immediately after weaning. Provision of water was most important during weaning transition and drinking behaviour patterns were compatible with response to stress. The results presented in this thesis demonstrate that different practices chosen by producers can impact calf performance, health and welfare. Therefore, increased producer awareness and use of science-informed practices are needed through additional outreach efforts.