cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A first estimate of the NNLO nonresonant corrections to top-antitop threshold production at lepton colliders
Creators: name: Ruiz-Femenia, Pedro
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We compute the dominant term in the expansion in rho=1-M_W/m_t of the unknown next-to-next-to-leading order (NNLO) nonresonant contributions to the e+ e- -> W+ W- b bbar total cross section at energies close to the top-antitop threshold. Our analytic result disagrees with a previous calculation by other authors [1]. We show that our determination has the correct infrared structure needed to cancel the divergences proportional to the top width arising in the resonant production of the same final state, and we point out to a missing contribution in the computation of [1] to explain the discrepancy.
description: 5 pages, 3 figures
The Antarctic Atmospheric Energy Budget. Part II: The Effect of Ozone Depletion and its Projected Recovery
Creators: name: Smith, Karen L.
name: Previdi, Michael
name: Polvani, Lorenzo M.
Publisher: name: Columbia University
Year: 2013
Subjects: Atmosphere
Atmosphere, Upper
Climatic changes

description: In this study we continue our investigation of the atmospheric energy budget of the Antarctic polar cap (the region poleward of 70°S) using integrations of the Whole Atmosphere Community Climate Model from the year 1960 to 2065. In agreement with observational data, we find that the climatological mean net top-of-atmosphere (TOA) radiative flux is primarily balanced by the horizontal energy flux convergence over the polar cap. On interannual timescales, changes in the net TOA radiative flux are also primarily balanced by changes in the energy flux convergence, with the variability in both terms significantly correlated with the Southern Annular Mode (SAM); positive and negative correlations, respectively. On multidecadal timescales, twentieth century stratospheric ozone depletion produces a negative trend in the net TOA radiative flux due to a decrease in the absorbed solar radiation within the atmosphere-surface column. The negative trend in the net TOA radiative flux is balanced by a positive trend in energy flux convergence, primarily in austral summer. This negative (positive) trend in the net TOA radiation (energy flux convergence) occurs despite a positive trend in the SAM, suggesting that the effects of the SAM on the energy budget are overwhelmed by the direct radiative effects of ozone depletion. In the twenty-first century, ozone recovery is expected to reverse the negative trend in the net TOA radiative flux, which would then, again, be balanced by a decrease in the energy flux convergence. Therefore, over the next several decades, ozone recovery will, in all likelihood, mask the effect of GHG warming on the Antarctic energy budget.
48CK302-596, Side Notched Point, Side 1
Creators: name: (:Unkn) Unknown
Publisher: name: University of Wyoming
Year: 2023
Subjects: Projectile Point
Side Notched
Quartzite
Vore Buffalo Jump
Bison
Bison Jump
Mass Kill Site
Archaeological Site
Northwest Plains Tribes
Sinkhole
Wyoming
Prehistoric
Archaeology

description: Image of a purple quartzite side notched projectile point, complete. Provenience: O-?-88"
Production of Heavy Particles by Protons on Protons
Creators: name: Afek, Y.
name: Margolis, B.
name: Polvani, Lorenzo M.
Publisher: name: Columbia University
Year: 1982
Subjects: subject: Physics
subject: Mathematics
subject: FOS: Mathematics

description: We calculate the production of heavy particles in the multi-GeV energy range using parton-model and statistical considerations. We discuss both central production and fragmentation. Our picture has implications for the question of the existence of a limiting temperature in hadron interactions.
Semi-classical approach to $J/ψ$ suppression in high energy heavy-ion collisions
Creators: name: Katz, Roland
name: Gossiaux, Pol Bernard
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the heavy quark/antiquark pair dynamics in strongly-coupled quark gluon plasma. A semi-classical approach, based on the Wigner distribution and Langevin dynamics, is applied to a color screened $c{\bar c}$ pair, in a hydrodynamically cooling fireball, to evaluate the total $J/ψ$ suppression at both RHIC and LHC energies. Although its limitation is observed, this approach results to a $J/ψ$ suppression of around 0.30 at RHIC and 0.25 at LHC.
description: 4 pages, 6 figures, Proceeding for International Conference on Strangeness in Quark Matter 2013 (SQM 2013) at Birmingham
Retrospektive Analyse der anatomischen und funktionellen Ergebnisse nach Pars Plana Vitrektomie mit konventionellem Ilm-Peeling versus invertrierter Ilm-Flap-Technik zur Behandlung des durchgreifenden Makulaforamens
Creators: name: Dera, Adrianna
Publisher: name: Universität Rostock
Year: 2022
Subjects: subject: 610 Medical sciences Medicine

description: Heutzutage erreicht man einen chirurgischen Verschluss des Makulaforamens bei 95% der Augen. Nicht nur der anatomische Verschluss, sondern auch eine Wiederherstellung der mikrostrukturellen Integrität der Netzhautaußenschichten korreliert mit der postoperativen Visusentwicklung. Die Pars-plana-Vitrektomie mit der inverted ILM-Flap Technik zeigte eine höhere Verschlussrate, sowie eine bessere postoperative Visusentwicklung im Vergleich zu einem konventionellen ILM-Peeling und sollte insbesondere bei Patienten mit großen Makulaforamina gegenüber dem klassischen ILM-Peeling bevorzugt werden.
Einfluss der ischämischen Fernkonditionierung (RIPC) auf die Kontraktilität und Funktion des linken Ventrikels in der transösophagealen Echokardiografie
Creators: name: Kletzin-Wagenknecht, Jana
Publisher: name: Universität Rostock
Year: 2022
Subjects: subject: 610 Medical sciences Medicine

description: Bei 91 Patienten (50 RIPC, 41 Kontrolle) wurden jeweils 4 Zyklen einer Ischämie am Oberarm gefolgt von 5min Reperfusion appliziert, um die Auswirkungen der RIPC auf das Myokard des LV zu untersuchen. Die Wandbewegung des linken Ventrikels wurde zu 4 Zeitpunkten echokardiografisch untersucht. Der Wandbewegungsscoreindex verschlechterte sich signifikant in beiden Gruppen kurz nach dem Ende der Herz-Lungen-Maschine in den septalen und basalen Segmenten und kehrte anschließend auf das Ausgangsniveau zurück. Die Rückbildung erfolgte in der RIPC-Gruppe etwas schneller als in der Kontrollgruppe.
Additional file 4 of Half-graben inversion tectonics revealed by gravity modeling in the Mikawa Bay Region, Central Japan
Creators: name: Miyakawa, Ayumu
name: Abe, Tomoya
name: Sumita, Tatsuya
name: Otsubo, Makoto
Publisher: name: figshare
Year: 2020
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Geophysics

description: Additional file 4: Supplementary Figure 1 and Figure 2.
Meeting report of the second European Biotransformation Workshop
Creators: name: Walles, M.
name: Pähler, A.
name: Isin, E.M.
name: Weidolf, L.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Inorganic Chemistry
subject: Science Policy
subject: Computational Biology

description: Challenges and opportunities in the field of biotransformation were presented and discussed at the 2nd European Biotransformation workshop which was conducted virtually in collaboration with the DMDG on November 24/25, 2021. Here we summarise the presentations and discussions from this workshop. The following topics were covered:Regulatory requirements and biotransformation studies for antibody drug conjugates (ADCs) and antisense oligonucleotides (ASOs)Solutions for mass spectral data processing of peptides and oligonucleotidesFuture outsourcing needs in biotransformation for new modalitiesEstablished quantitative and qualitative workflows for metabolite identificationNew in vitro systems to study new chemical entities (NCEs) with low metabolic turnoverNew strategies on the timing of the human ADME (absorption, distribution, metabolism, excretion) study and to investigate the impact of human microbiome on drug development Regulatory requirements and biotransformation studies for antibody drug conjugates (ADCs) and antisense oligonucleotides (ASOs) Solutions for mass spectral data processing of peptides and oligonucleotides Future outsourcing needs in biotransformation for new modalities Established quantitative and qualitative workflows for metabolite identification New in vitro systems to study new chemical entities (NCEs) with low metabolic turnover New strategies on the timing of the human ADME (absorption, distribution, metabolism, excretion) study and to investigate the impact of human microbiome on drug development
Expression von Arzneistofftransportern in der humanen Plazenta
Creators: name: Stückrad, Oke
Publisher: name: Universität Rostock
Year: 2022
Subjects: subject: 610 Medical sciences Medicine

description: Die Dissertation untersuchte die Expression relevanter Arzneistofftransporter der humanen Plazenta auf mRNA- und Proteinebene. Hierbei erfolgte die Darstellung der Expression zum Zeitpunkt des errechneten Geburtstermins bei gesunden Probandinnen (N = 156) sowie die Veränderung der Expressionsmuster im zeitlichen Verlauf der Gestation (N = 245) und bei Auftreten von Gestationsdiabetes (N = 173) und (Prä-)Eklampsie (N = 165).
Magnified image of CK302-2306 with polishing on bone tool from bison metatarsal
Creators: name: (:Unkn) Unknown
Publisher: name: University of Wyoming
Year: 2023
Subjects: Metatarsal
Polishing
Bone Tool
Vore Buffalo Jump
Bison
Bison Jump
Mass Kill Site
Archaeological Site
Northwest Plains Tribes
Sinkhole
Wyoming
Prehistoric
Archaeology

description: Metatarsal anterior aspect at 8.2 magnification.
Untersuchung des Zusammenhangs zwischen Dysregulation im Fettstoffwechsel und pathologischen Markern der Alzheimer-Krankheit
Exploring the relationship between dysregulation in the lipid metabolism and the pathological hallmarks of Alzheimer’s disease
Creators: name: Sakr, Fatemah
Publisher: name: Universität Rostock
Year: 2022
Subjects: subject: 610 Medical sciences Medicine

description: This doctoral dissertation explored novel biomarkers that could reinforce diagnostic accuracy and predict disease progression in the early phases of AD. Such biomarkers are expected to allow the stratification of individuals based on the risk associated with their specific pathology burden, i.e., region-specific cortical amyloidosis and lipids dysregulations. Both approaches enabled higher precision in research participants' characterization, which could be crucial in planning clinical trials and adopting new interventions in prevention trials.
Magnified image of CK302-2306 with polishing on bone tool from bison metatarsal
Creators: name: (:Unkn) Unknown
Publisher: name: University of Wyoming
Year: 2023
Subjects: Metatarsal
Polishing
Bone Tool
Vore Buffalo Jump
Bison
Bison Jump
Mass Kill Site
Archaeological Site
Northwest Plains Tribes
Sinkhole
Wyoming
Prehistoric
Archaeology

description: Metatarsal medial aspect at 8.0 magnification.
Filamentation of Unstable Vortex Structures via Separatrix Crossing: A Quantitative Estimate of Onset Time
Creators: name: Polvani, Lorenzo M.
name: Flierl, G. R.
name: Zabusky, N. J.
Publisher: name: Columbia University
Year: 1989
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Physics

description: The onset of filamentation for compact vortex structures in two-dimensional incompressible flows is elucidated. An estimate is presented for the filamentation time of an unstably perturbed Kirchhoff ellipse, obtained from a linear analysis of the geometry of the instantaneous corotating streamfunction.
48CK302-359, Complete Biface, Side 2
Creators: name: (:Unkn) Unknown
Publisher: name: University of Wyoming
Year: 2023
Subjects: Biface
Quartzite
Vore Buffalo Jump
Bison
Bison Jump
Mass Kill Site
Archaeological Site
Northwest Plains Tribes
Sinkhole
Wyoming
Prehistoric
Archaeology

description: Image of a tan quartzite biface, complete. Provenience: E1-4-13"
Wave–Wave Interaction of Unstable Baroclinic Waves
Creators: name: Pedlosky, Joseph
name: Polvani, Lorenzo M.
Publisher: name: Columbia University
Year: 1987
Subjects: subject: Atmosphere
subject: Mathematics
subject: FOS: Mathematics
subject: Physics

description: Two slightly unstable baroclinic waves in the two-layer Phillips model are allowed to interact with each other as well as the mean flow. A theory for small dissipation rates is developed to examine the role of wave–wave interaction in the dynamics of vacillation and aperiodicity in unstable systems. It is shown that the form of the dissipation mechanism as well as the overall dissipation timescale determines the nature of the dynamics. In particular, dissipation proportional to potential vorticity is shown to expunge amplitude vacillation due to wave–mean flow interactions. Wave–wave interaction, however, can yield amplitude vacillation. As the dissipation is decreased, the solutions evolve from steady waves (although propagating) to periodic vacillation until finally at small dissipation rates, chaotic behavior is obtained. This occurs in a range of relative growth rates of the two waves which depends on the strength of the wave–wave and wave–mean flow interactions.
Design, Modeling and Testing of the Askaryan Radio Array South Pole Autonomous Renewable Power Stations
Creators: name: Besson, D. Z.
name: Kennedy, D. M.
name: Ratzlaff, K.
name: Young, R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We describe the design, construction and operation of the Askaryan Radio Array (ARA) Autonomous Renewable Power Stations, initially installed at the South Pole in December, 2010 with the goal of providing an independently operating 100 W power source capable of year-round operation in extreme environments. In addition to particle astrophysics applications at the South Pole, such a station can easily be, and has since been, extended to operation elsewhere, as described herein.
description: 33 pages, 28 figures
The Effect of Dissipation on Spatially Growing Nonlinear Baroclinic Waves
Creators: name: Polvani, Lorenzo M.
name: Pedlosky, J.
Publisher: name: Columbia University
Year: 1988
Subjects: subject: Atmosphere
subject: Physics
subject: Mathematics
subject: FOS: Mathematics

description: The question of convective (i.e., spatial) instability of baroclinic waves on an f-plane is studied in the context of the two-layer model. The viscous and inviscid marginal curves for linear convective instability are obtained. The finite-amplitude problem shows that when dissipation is O(1) it acts to stabilize the waves that are of Eady type. For very small dissipation the weakly nonlinear analysis reveals that at low frequencies, contrary to what is known to occur in the temporal problem, in addition to the baroclinic component a barotropic correction to the “mean” flow is generated by the nonlinearities, and spatial equilibration occurs provided the ratio of shear to mean flow does not exceed some critical value. In the same limit, the slightly dissipative nonlinear dynamics reveals the presence of large spatial vacillations immediately downstream of the source, even if asymptotically (i.e., very far away from the source) the amplitudes are found to reach steady values. No case of period doubling or aperiodic behavior was found. The results obtained seem to be qualitatively independent of the form chosen to model the dissipation.
Magnified image of CK302-7143 with polishing on bone tool from bison metatarsal
Creators: name: (:Unkn) Unknown
Publisher: name: University of Wyoming
Year: 2023
Subjects: Metatarsal
Polishing
Bone Tool
Vore Buffalo Jump
Bison
Bison Jump
Mass Kill Site
Archaeological Site
Northwest Plains Tribes
Sinkhole
Wyoming
Prehistoric
Archaeology

description: Metatarsal medial aspect at 8.3 magnification.
Two-Layer Geostrophic Vortex Dynamics. Part 1. Upper-Layer V-States and Merger
Creators: name: Polvani, Lorenzo M.
name: Flierl, G. R.
name: Zabusky, N. J.
Publisher: name: Columbia University
Year: 1989
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Physics
subject: Atmosphere

description: We generalize the methods of two-dimensional contour dynamics to study a two-layer rotating fluid that obeys the quasi-geostrophic equations. We consider here only the case of a constant-potential-vorticity lower layer. We derive equilibrium solutions for monopolar (rotating) and dipolar (translating) geostrophic vortices in the upper layer, and compare them with the Euler case. We show that the equivalent barotropic (infinite lower layer) case is a singular limit of the two-layer system. We also investigate the effect of a finite lower layer on the merger of two regions of equal-sign potential vorticity in the upper layer. We discuss our results in the light of the recent laboratory experiments of Griffiths and Hopfinger (1986). The process of filamentation is found to be greatly suppressed for equivalent barotropic dynamics on scales larger than the radius of deformation. We show that the variation of the critical initial distance for merger as a function of the radius of deformation and the ratio of the layers at rest is closely related to the existence of vortex-pair equilibria and their geometrical properties.
Directional locking in deterministic lateral displacement microfluidic separation systems
Creators: name: Risbud, Sumedh R.
name: Drazer, German
Publisher: name: arXiv
Year: 2014
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We analyze the trajectory of suspended spherical particles moving through a square array of obstacles, in the deterministic limit and at zero Reynolds number. We show that, in the dilute approximation of widely separated obstacles, the average motion of the particles is equivalent to the trajectory followed by a point particle moving through an array of obstacles with an effective radius. The effective radius accounts for the hydrodynamic as well as short-range repulsive non-hydrodynamic interactions between the suspended particles and the obstacles and is equal to the critical offset at which particle trajectories become irreversible. Using this equivalent system we demonstrate the presence of directional locking in the trajectory of the particles and derive an inequality that accurately describes the Devil's staircase type of structure observed in the migration angle as a function of the forcing direction. Finally, we use these results to determine the optimum resolution in the fractionation of binary mixtures using deterministic lateral displacement separation microfluidic systems.
Characterization of pathway specific inhibitor response in pancreatic ductal adenocarcinoma in vitro models with different genetic backgrounds
Creators: name: Ma, Yixuan
Publisher: name: Universität Rostock
Year: 2022
Subjects: subject: 610 Medical sciences Medicine

description: Key proteins such as CK2, CDK, PI3K, AKT and KRAS are often considered as promising target molecules for therapeutic intervention strategies due to their important roles in the occurrence, development and prognosis of PDAC. The aim of this doctoral thesis was to explore the different effects of the above-mentioned key protein inhibitors on various PDAC cell lines, and to explore the effect of aberrations in the target genes of the inhibitors on the efficacy of the corresponding inhibitors by applying whole-exome sequencing (WES) and RNA sequencing (RNA-seq).
Metabolism of gartanin in liver microsomes and its modulating effects on cytochrome P450s
Creators: name: Tao, Jia
name: Ai, Hao
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Inorganic Chemistry
subject: 60506 Virology
subject: Computational Biology

description: Gartanin, a compound found in mangosteen, has various pharmacological activities, including anticancer, anti-inflammation, and antioxidation.In the present study, we reported differences of gartanin metabolism among species and the effect of gartanin on cytochrome P450 (CYP) activities and protein expression.We found significant difference in gartanin metabolism among species, where rabbits and humans had similar metabolic characteristics. Five CYP-catalysed metabolites and three glucuronosyltransferase (UGT)-catalysed metabolites were identified by LC-MS/MS. Hydroxylation was the major metabolic pathway. Gartanin exhibited mixed inhibition on CYP1A2 activity with IC50 and Ki values of 1.48 and 3.71 μM, respectively. In addition, gartanin down-regulated the protein expressions of CYP2C9 and CYP2D6 and up-regulated the protein expression of CYP2D6. The present study supports the pharmacological and toxicological research of gartanin. Gartanin, a compound found in mangosteen, has various pharmacological activities, including anticancer, anti-inflammation, and antioxidation. In the present study, we reported differences of gartanin metabolism among species and the effect of gartanin on cytochrome P450 (CYP) activities and protein expression. We found significant difference in gartanin metabolism among species, where rabbits and humans had similar metabolic characteristics. Five CYP-catalysed metabolites and three glucuronosyltransferase (UGT)-catalysed metabolites were identified by LC-MS/MS. Hydroxylation was the major metabolic pathway. Gartanin exhibited mixed inhibition on CYP1A2 activity with IC50 and Ki values of 1.48 and 3.71 μM, respectively. In addition, gartanin down-regulated the protein expressions of CYP2C9 and CYP2D6 and up-regulated the protein expression of CYP2D6. The present study supports the pharmacological and toxicological research of gartanin.
48CK302-617, Side Notched Point, Side 2
Creators: name: (:Unkn) Unknown
Publisher: name: University of Wyoming
Year: 2023
Subjects: Projectile Point
Side Notched
Quartzite
Vore Buffalo Jump
Bison
Bison Jump
Mass Kill Site
Archaeological Site
Northwest Plains Tribes
Sinkhole
Wyoming
Prehistoric
Archaeology

description: Image of a purple quartzite side notched projectile point with a concave base, complete. Provenience: unknown
Chaotic Lagrangian Trajectories around an Elliptical Vortex Patch Embedded in a Constant and Uniform Background Shear Flow
Creators: name: Polvani, Lorenzo M.
name: Wisdom, J.
Publisher: name: Columbia University
Year: 1990
Subjects: subject: Physics
subject: Mathematics
subject: FOS: Mathematics

description: The Lagrangian flow around a Kida vortex [J. Phys. Soc. Jpn. 5 0, 3517 (1981)], an elliptical two‐dimensional vortex patch embedded in a uniform and constant background shear, is described by a nonintegrable two‐degree‐of‐freedom Hamiltonian. For small values of shear, there exist large chaotic zones surrounding the vortex, often much larger than the vortex itself and extremely close to its boundary. Motion within the vortex is integrable. Implications for two‐dimensional turbulence are discussed.
Delayed Southern Hemisphere Climate Change Induced by Stratospheric Ozone Recovery, as Projected by the CMIP5 Models
Creators: name: Barnes, Elizabeth A.
name: Barnes, Nicholas W.
name: Polvani, Lorenzo M.
Publisher: name: Columbia University
Year: 2013
Subjects: Atmosphere
Atmosphere, Upper
Climatic changes

description: Stratospheric ozone is expected to recover by the end of this century due to the regulation of ozone depleting substances by the Montreal Protocol. Targeted modeling studies have suggested that the climate response to ozone recovery will greatly oppose the climate response to rising greenhouse-gas (GHG) emissions. However, the extent of this cancellation remains unclear since only a few such studies are available. Here, we analyze a much larger set of simulations performed for the Coupled Model Intercomparison Project, phase 5, all of which include ozone recovery. We show that the closing of the ozone hole will cause a delay in summer-time (DJF) Southern Hemisphere climate change, between now and 2045. Specifically, we find that the position of the jet stream, the width of the subtropical dry-zones, the seasonality of surface temperatures, and sea ice concentrations all exhibit significantly reduced summer-time trends over the first half of the 21st Century as a consequence of ozone recovery. After 2045, forcing from GHG emissions begins to dominate the climate response. Finally, comparing the relative influences of future GHG emissions and historic ozone depletion, we find that the simulated DJF tropospheric circulation changes between 1965-2005 (driven primarily by ozone depletion) are larger than the projected changes in any future scenario over the entire 21st Century.
Magnified image of CK302-16089 with root etching on bison talus.
Creators: name: (:Unkn) Unknown
Publisher: name: University of Wyoming
Year: 2023
Subjects: Talus
Root Etching
Vore Buffalo Jump
Bison
Bison Jump
Mass Kill Site
Archaeological Site
Northwest Plains Tribes
Sinkhole
Wyoming
Prehistoric
Archaeology

description: Talus inferior aspect at 10 magnification.
Peripheral neuropathy in ALS: phenotype association
Creators: name: Gromicho, Marta
name: Pinto, Susana
name: Andersen, Peter M.
name: Grosskreutz, Julian
name: Kuźma-Kozakiewicz, Magdalena
name: Petri, Susanne
name: Uysal, Hilmi
name: Mamede De Carvalho
Publisher: name: F1000 Research Limited
Year: 2018

description: Introduction: The association between peripheral neuropathy (PNP) and amyotrophic lateral sclerosis (ALS) has been described before, present in about 15-20% of the ALS patients1. Severity is usually mild, the associated phenotype(s), cofounders, genotypes and pathogenesis are unknown.

Methods: We prospectively applied our clinical protocol2 (OnWebDuals project) to characterize phenotype-genotype and risk-factors, in a population of 339 consecutive ALS patients, followed in Lisbon. We characterized region-of-onset, sex, disease duration, weight-loss before disease-onset (>10%), diabetes, previous history of chemotherapy or other toxic agents, and SOD1 and C9orf72 mutations. The study cohort underwent standardized nerve conduction studies at first consultation, including 2 or more sensory nerves in lower limbs. Sensory nerve amplitude < mean+2.5SD (compared with age-matched controls) was accepted as indicating neuropathy. Patients were grouped in Group 1 (no PNP) and Group 2 (with PNP).

Results: 29 patients (8.6%) were in G2. The proportion of men (169 G1 vs 22 G2, p=0.03) and mean age at disease onset (67.31±13.03SD G1 vs 61.00±13.44SD G2, p=0.02) were higher in G2. Disease duration (41.79±55.23SD G1 vs 32.38±36.57SD in G2, p=0.22) was similar between groups. Weight-loss was found in 51 patients G2 and 2 G1 (p=0.28), diabetes in 4 in G2 and 35 in G1 (p=0.76), previous chemotherapy in 7 patients G2 and 1 in G1 (p=0.52), and C9Orf72 mutation was positive in 1 G1 and in 17 in G2 (p=1). Three patients with SOD mutation were in G1. Bulbar and spinal-onset patients were equally distributed between groups (p=0.64 and 0.83). Respiratory-onset occurred in 4 patients in G2 (13.8%) and in 7 in G1 (2.3%) - p=0.009. Logistic regression confirmed that age (p=0.01), gender (p=0.03) and respiratory-onset (p=0.003, b=4.37), were independent predictors for PNP.

Conclusions: PNP was found in 8.6% of our patients. In the group of patients with PNP, diabetes, weight-loss or C9orf72HRE mutation were not a risk-factor. However, PNP was more frequent in older men and, in particular, in patients with respiratory presentation. We speculate that peripheral hypoxia in vasa nervorum is associated with peripheral nerve injury in ALS.

1.      Pugdahl K, Fuglsang-Frederiksen A, De Carvalho M, et al. Generalised sensory system abnormalities in amyotrophic lateral sclerosis: A European multicentre study. J Neurol Neurosurg Psychiatry. 2007;78(7):746-749. doi:10.1136/jnnp.2006.098533.
2.      De Carvalho M, Ryczkowski A, Andersen P, et al. International Survey of ALS Experts about Critical Questions for Assessing Patients with ALS. Amyotroph Lateral Scler Front Degener. 2017;0(0):1-6. doi:10.1080/21678421.2017.1349150.
On Verifying Resource Contracts using Code Contracts
Creators: name: Castaño, Rodrigo
name: Galeotti, Juan Pablo
name: Garbervetsky, Diego
name: Tapicer, Jonathan
name: Zoppi, Edgardo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Software Engineering (cs.SE)
subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences
subject: D.2.4

description: In this paper we present an approach to check resource consumption contracts using an off-the-shelf static analyzer. We propose a set of annotations to support resource usage specifications, in particular, dynamic memory consumption constraints. Since dynamic memory may be recycled by a memory manager, the consumption of this resource is not monotone. The specification language can express both memory consumption and lifetime properties in a modular fashion. We develop a proof-of-concept implementation by extending Code Contracts' specification language. To verify the correctness of these annotations we rely on the Code Contracts static verifier and a points-to analysis. We also briefly discuss possible extensions of our approach to deal with non-linear expressions.
description: In Proceedings LAFM 2013, arXiv:1401.0564
null Einfluss des E2F1/miR-888/APLF-Signalweges auf die c-NHEJ-vermittelte DNA-Doppelstrangbruch-Reparatur und Tumorprogression im humanen Harnblasenkarzinom
Creators: name: Richter, Christin
Publisher: name: Universität Rostock
Year: 2022
Subjects: subject: 570 Life science

description: Muskelinvasive Blasenkarzinome (BC) sind durch genomische Instabilität und erhöhte E2F1-Level gekennzeichnet. In BC-Zelllinien konnte gezeigt werden, dass E2F1 am DNA-Reparaturmechanismus c-NHEJ beteiligt ist, indem es c-NHEJ-Faktoren direkt transaktiviert und gleichzeitig APLF durch Aktivierung der OncomiR hsa-miR-888-5p herunterreguliert. Der E2F1/miR-888/APLF-Signalweg hat negative Auswirkungen auf die DSB-Reparatur und fördert Krebsprogression. Die Ergebnisse dieser Arbeit eröffnen neue mechanistische Einblicke in die Entstehung genomischer Instabilität und BC-Progression.
Un percorso interdisciplinare per la ricostruzione degli orizzontamenti lignei delle domus romane
Creators: name: Sbrogiò, Luca
name: Bertolazzi, Angelo
name: Turrini, Umberto
name: Valluzzi, Maria Rosa
name: Centola, Vanessa
name: Bonetto, Jacopo
Publisher: name: Restauro Archeologico
Year: 2018

description: In most cases, archaeological excavations provide very little information about buildings’ upper parts, such as roof and floors, except for a few peculiar cases, such as Pompeii, Herculaneum and ancient Ostia. Being wood less durable than masonry, our knowledge of the rules and the principles commonly used in Antiquity to design timber structures is still limited to hypothesis. Ancient writers, such as Plinius or Vitruvius, cannot help either, due to the recurrent difficulty of interpreting structural details and technical aspects discussed in their essays. In the paper, an integrated method, able to combine the archaeological data with the architectural knowledge of the Antiquity and the support of engineering analyses, is proposed. Based on limited information already available and through the application of the simplified kinematic approach, unknown geometrical data of the Roman house have been identified through analytical formulas, thus linking a house's floor layout to its elevation. In particular, starting from the linking of the house's floor layout to its elevation, dimensional criteria for timber beams and the roof's pitch in agreement with the archaeological evidence have been defined.
description: Restauro Archeologico, Vol. 26 No. 2 (2018)
Bildgebende und klinische Korrelate der Gadolinium-Akkumulation im Gehirn
Creators: name: Kühn, Isabelle
Publisher: name: Universität Rostock
Year: 2022
Subjects: subject: 610 Medical sciences Medicine

description: In Zusammenschau aller Ergebnisse dieser Studie lässt sich formulieren, dass lineare GBCAs zu keiner offensichtlichen Schädigung der Hirnfunktion führen. Zudem sprechen die vorliegenden Befunde gegen stärkere gewebetoxische Veränderungen (bzgl. fehlender Gliose oder Verkalkung)Diese Schlussfolgerungen stützen damit Ergebnisse bisheriger Studien. Ein schwacher negativer biologischer Effekt kann jedoch nicht ausgeschlossen werden. Es bedarf weiterer größer angelegter Studien zur eindeutigen Klärung der Fragestellung.
Magnified image of CK302-18789 with polishing on bone tool from bison metatarsal
Creators: name: (:Unkn) Unknown
Publisher: name: University of Wyoming
Year: 2023
Subjects: Metatarsal
Impact Fracture
Vore Buffalo Jump
Bison
Bison Jump
Mass Kill Site
Archaeological Site
Northwest Plains Tribes
Sinkhole
Wyoming
Prehistoric
Archaeology

description: Metatarsal lateral aspect at 8.2 magnification.
Columen, cantherii, transtra et capreoli: intorno alla genesi delle incavallature lignee
Creators: name: Ruggieri, Nicola
Publisher: name: Restauro Archeologico
Year: 2018

description: The herein paper proposes a diachronic analysis of the timber carpentry roof in the roman context. It is based on cross attestations deriving from ancient literary sources, the iconography emphasized in artefacts belonging to different figurative arts that reproduce timber structures and on the beam sockets still present in some constructions. The analysed roof carpentries developed in antiquity in Greece, Magna Graece and Etruria, were , in general, constituted by a horizontal member on which struts rest, with the role of supporting two oblique members that form the roof pitch. An organization that persisted in the roman constructive culture at least until the 4th century when the truss system, able to generate new interrelations among the component elements, became particularly widespread.
description: Restauro Archeologico, Vol. 26 No. 2 (2018)
Generalized Kirchhoff Vortices
Creators: name: Polvani, Lorenzo M.
name: Flierl, G. R.
Publisher: name: Columbia University
Year: 1986
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Physics

description: A family of exact solutions of the Euler equations is presented: they are generalizations of the Kirchhoff vortex to N confocal ellipses. Special attention is given to the case N=2, for which the stability is analyzed with a method similar to the one used by Love [Proc. London Math. Soc. 1, XXV 18 (1893)] for the Kirchhoff vortex. The results are compared with those for the corresponding circular problem.
Dialettica del rudere urbano: storia di un isolato Shikumen a Shanghai
Creators: name: Frulio, Gabriela
Publisher: name: Restauro Archeologico
Year: 2018

description: Regeneration and renewal are the contemporary topics for the management activities in historical areas of Shanghai. Introducing a personal experience, the author argues the main projects which have affected the historical compounds in Shanghai during the last twenty years, with particular reference to the Shikumen block (typical housing since the urban expansion in the late XIX century). The building in Shikumen style, characterized by terraced houses with high population density and inhabited by lower working classes until today, behind the name of restoration has been replaced with low population density building addressed to reach people, as gentrification strategy. The constructions are quite often rebuilt in the same style with a particular mix of invention and anastilosi or new parts in contemporary style.
description: Restauro Archeologico, Vol. 26 No. 2 (2018)
I terremoti del I secolo d.C. a Pompei. Osservazioni intorno ai danni e consolidamenti nelle Terme Stabiane con particolare riguardo ad uno sperone nel Destrictarium
Creators: name: Ruggieri, Nicola
name: Galassi, Stefano
name: Tempesta, Giacomo
Publisher: name: Restauro Archeologico
Year: 2018

description: The 62 AD represents for Pompeii the beginning of a sequence of telluric events culminating with the complete town burial provoked by the Vesuvius’ eruption. The traces of those earthquakes, some of which of high magnitude able to produce damage to the constructions, are still detectable on the ancient structures. The paper analyzes some significant masonry walls of the Terme Stabiane emphasizing cracks and deformations due to two distinct earthquakes, by evaluating the reconstruction, repair and strengthening interventions carried out during the roman age. Furthermore, a constructive analysis, conducted on the buttress present in the destrictarium and regarding the materials and their organization, with the aid of the Mechanics, have provided information on the chronology of the events occurred, in sequence, during the 1st century AD.
description: Restauro Archeologico, Vol. 26 No. 2 (2018)
Spin Transfer Torque Generated by the Topological Insulator Bi_2Se_3
Creators: name: Mellnik, A. R.
name: Lee, J. S.
name: Richardella, A.
name: Grab, J. L.
name: Mintun, P. J.
name: Fischer, M. H.
name: Vaezi, A.
name: Manchon, A.
name: Kim, E. -A.
name: Samarth, N.
name: Ralph, D. C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Magnetic devices are a leading contender for implementing memory and logic technologies that are nonvolatile, that can scale to high density and high speed, and that do not suffer wear-out. However, widespread applications of magnetic memory and logic devices will require the development of efficient mechanisms for reorienting their magnetization using the least possible current and power. There has been considerable recent progress in this effort, in particular discoveries that spin-orbit interactions in heavy metal/ferromagnet bilayers can yield strong current-driven torques on the magnetic layer, via the spin Hall effect in the heavy metal or the Rashba-Edelstein effect in the ferromagnet. As part of the search for materials to provide even more efficient spin-orbit-induced torques, some proposals have suggested topological insulators (TIs), which possess a surface state in which the effects of spin-orbit coupling are maximal in the sense that an electron's spin orientation is locked relative to its propagation direction. Here we report experiments showing that charge current flowing in-plane in a thin film of the TI Bi_2Se_3 at room temperature can indeed apply a strong spin-transfer torque to an adjacent ferromagnetic permalloy (Py = Ni81Fe19) thin film, with a direction consistent with that expected from the topological surface state. We find that the strength of the torque per unit charge current density in the Bi_2Se_3 is greater than for any other spin-torque source material measured to date, even for non-ideal TI films wherein the surface states coexist with bulk conduction. Our data suggest that TIs have potential to enable very efficient electrical manipulation of magnetic materials at room temperature for memory and logic applications.
description: 34 pages; Supplementary information included
Palazzo Capponi delle Rovinate a Firenze: analisi e valutazioni per il progetto di restauro
Creators: name: Minutoli, Giovanni
Publisher: name: Restauro Archeologico
Year: 2018

description: Palazzo Capponi delle Rovinate, was build between 1406 and 1426, it was commissioned from Niccolò da Uzzano and Lorenzo di Bicci, to young Filippo Brunelleschi, as written from Vasari, do the recent studies evidence. According the 1427 cadastre the building is accountant as build and actually used by the family. After the death of the Uzzanos brothers, the building passes trough wedding to the Capponi’s family. The name “Rovinate” comes form the continuous landslides happening in that area, for this reason the name Rovinate, comes from. The relief of the building and the analysis of the deterioration, architectonical and structural, have affected mostly the basement, ground floor, mezzanino and the under roof areas, the intermediate levels were not accountable of relief, because the are residential. Although, they were inspected, and the cracking framework seems aligned with the rest of the evidence. The conducted studies allowed us to understand the evolution phases of the structures also the nature of the materials and techniques used and the peculiarities of the geological underground. The failure analysis reviled a rotary translation, in the south-west corner of the building, followed by cracks in the opposite corner, accounted as strange.
description: Restauro Archeologico, Vol. 26 No. 2 (2018)
Einfluss von Sauerstoff und Katecholaminen auf die fetale kortikale Entwicklung der Maus
Creators: name: Markert, Franz
Publisher: name: Universität Rostock
Year: 2022
Subjects: subject: 570 Life science
subject: 610 Medical sciences Medicine

description: Die Arbeit verbessert grundlegend das Verständnis der Gehirnentwicklung und zeigt Sauerstoff und Noradrenalin als Schlüsselfaktoren der fetalen Neurogenese auf. Zudem wurde ein bislang gänzlich unbekannter Regulationsmechanismus der initialen Anzahl an kortikalen Neuronen durch Mikroglia entdeckt.
48CK302-384, Retouched Tool Fragment, Side 2
Creators: name: (:Unkn) Unknown
Publisher: name: University of Wyoming
Year: 2023
Subjects: Projectile Point
Flake Tool
Quartzite
Vore Buffalo Jump
Bison
Bison Jump
Mass Kill Site
Archaeological Site
Northwest Plains Tribes
Sinkhole
Wyoming
Prehistoric
Archaeology

description: Image of a gray quartzite retouched tool fragment, use unknown. Provenience: E1-?-4
QCD Exotics
Creators: name: Olsen, Stephen Lars
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: QCD-motivated models for hadrons predict an assortment of "exotic" hadrons that have structures that are more complex then the quark-antiquark mesons and three-quark baryons of the original quark-parton model. These include pentaquark baryons, the six-quark H-dibaryon, and tetra-quark, hybrid, and glueball mesons. Despite extensive experimental searches, no unambiguous candidates for any of these exotic configurations have yet to be identified. On the other hand, a number of meson states, one that seems to be a proton-antiproton bound state, and others that contain either charmed-anticharmed quark pairs or bottom-antibottom quark pairs, have been recently discovered that neither fit into the quark-antiquark meson picture nor match the expected properties of the QCD-inspired exotics. Here I briefly review results from a recent search for the H-dibaryon, and discuss some properties of the newly discovered states --the so-called XYZ mesons-- and compare them with expectations for conventional quark-antiquark mesons and the predicted QCD-exotic states.
description: 11 pages, 8 figures, to appear in the proceedings of LEAP 2013
48CK302-415, Side Notched Point, Side 1
Creators: name: (:Unkn) Unknown
Publisher: name: University of Wyoming
Year: 2023
Subjects: Projectile Point
Side Notched
Porcellanite
Vore Buffalo Jump
Bison
Bison Jump
Mass Kill Site
Archaeological Site
Northwest Plains Tribes
Sinkhole
Wyoming
Prehistoric
Archaeology

description: Image of a gray porcellanite side notched projectile point, base fragment. Also missing part of one tang. Provenience: N1-2-24"
Distress analysis of mice used for translational research
Creators: name: Xie, Wentao
Publisher: name: Universität Rostock
Year: 2022
Subjects: subject: 570 Life science
subject: 610 Medical sciences Medicine

description: The assessment and improvement of animal welfare is not only an ethical requirement, but also a guarantee of efficient and high quality translational research. In recent years, sophisticated animal models were created to study human diseases. However, the assessment of distress in these animal models is scarce. In order to provide a solid basis for optimizing animal welfare in future studies, body weight, burrowing, nesting activity, faecal corticosterone metabolites (FCMs), and distress scores were analyzed in several animal models.
Einfluss des IWATE-Schwierigkeitsgrades bei offener und laparoskopischer anatomischer Leberresektion auf das intra- und postoperative Outcome
Creators: name: Aldarwish, Saeed
Publisher: name: Universität Rostock
Year: 2022
Subjects: subject: 610 Medical sciences Medicine

description: Diese Studie analysiert retrospektiv die Vor- und Nachteile jedes operativen Verfahrens (offen vs. laparoskopisch) bei anatomischer Leberresektionen in Abhängigkeit von operativem OP-Schwierigkeitsgrad (IWATE-Kriterien). Bei anspruchsvollen anatomischen Leberresektionen hat die offene Methode in dieser Studie nur einen Vorteil in einer kürzeren OP-Zeit im Vergleich zur laparoskopischen LR. Außerdem zeigt die laparoskopische Methode die wenigsten Komplikationen, auch bei anspruchsvollen anatomischen LR, wenn der Chirurg gut trainiert ist und ausreichende Erfahrung hat.
Rossby Wave Breaking, Microbreaking, Filamentation, and Secondary Vortex Formation: The Dynamics of a Perturbed Vortex
Creators: name: Polvani, Lorenzo M.
name: Plumb, R. Alan
Publisher: name: Columbia University
Year: 1992
Subjects: Atmosphere
Atmosphere, Upper
Physics

description: The behavior of an isolated vortex perturbed by topographically forced Rossby waves is studied using the method of Contour Dynamics. For a single-contour vortex a distinct forcing threshold exists above which the wave breaks in a dynamically significant way, leading to a disruption of the vortex. This breaking is distinguished from the process of weak filamentary breaking described by Dritschel and classified here as microbreaking; the latter occurs in nondivergent flow even at very small forcing amplitudes but does not affect the vortex in a substantial manner. In cases with finite Rossby deformation radius (comparable with the vortex radius) neither breaking nor microbreaking occurs below the forcing threshold. In common with previous studies using high-resolution spectral models, the vortex is not diluted by intrusion of outside air, except during remerger with a secondary vortex shed previously from the main vortex during a breaking event. The kinematics of the breaking process and of the vortex interior and the morphology of material ejected from the vortex are described. When the Rossby radius is finite there is substantial mixing in the deep interior of the vortex, even when the vortex is only mildly disturbed. Implications for the stratospheric polar vortex are discussed.
48CK302-493, Side Notched Point, Side 2
Creators: name: (:Unkn) Unknown
Publisher: name: University of Wyoming
Year: 2023
Subjects: Projectile Point
Side Notched
Quartzite
Vore Buffalo Jump
Bison
Bison Jump
Mass Kill Site
Archaeological Site
Northwest Plains Tribes
Sinkhole
Wyoming
Prehistoric
Archaeology

description: Image of a tan quartzite side notched projectile point, base and midsection only. Provenience: W2-1--56" BSD