cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Structural basis for the selectivity of 3rd generation EGFR inhibitors: a molecular dynamics study
Creators: name: Gad, Mazen M.
name: Abdelwaly, Ahmad
name: Helal, Mohamed A.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
classificationCode: 110309
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Activating mutations in the EGFR kinase domain are known to be a common cause of Non-Small Cell Lung Cancer (NSCLC) and are thus targeted for treatment. First generation Tyrosine Kinase Inhibitors (TKIs) were used to treat NSCLC patients with the known activating mutations L858R and exon 19 deletion but were resisted by a second mutation T790M in the active site of the kinase domain. Second generation members of TKIs have an electrophilic moiety that can form a covalent bond with Cys797 and are effective against T790M EGFR but are toxic because they inhibit WT EGFR as well. Third generation TKIs, like Osimertinib, can bind to and irreversibly inhibit T790M mutants selectively, while sparing the wild-type enzyme. Thus, they possess a better safety profile and a wider therapeutic window. However, the reason behind their selectivity is still not well understood. In this study, computational MD simulations were carried out on Osimertinib in complex with both WT and L858R/T790M Double Mutant (DM) EGFR to provide an insight into the selectivity of Osimertinib and its molecular interactions within the active site. A high-resolution trajectory analysis showed that the key selectivity residues are Val726, met793, and Cys797. Interaction of Osimertinib with these residues is improved due to the T790M mutation which optimizes the ligand orientation for binding, as evident from the RMSD and the distances monitored. These results can provide guidance for the development of more selective 3rd generation EGFR TKIs. Communicated by Ramaswamy H. Sarma
title: Von der Arithmetik zur Algebra
title: Wege zu einem inhaltlichen Verständnis von Variablen, Termen und Termstrukturen
titleType: AlternativeTitle
Creators: name: Marxer, Michael
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2012
Subjects: subject: 510

description: Arithmetik ist mehr als das Berechnen von Termwerten, Algebra ist mehr als das Umformen von Termen: Bereits in der Arithmetik kann das inhaltliche Verständnis für Algebra geweckt werden. Die Struktur einer Situation spiegelt sich in der Struktur von Termen wider, und Terme können als universales Werkzeug für die Darstellung strukturgleicher Situationen verwendet werden. Dazu werden Aufgabenformate vorgestellt, die das inhaltliche Verständnis für Terme und Termstrukturen anbahnen können.
Multi-photon subtracted thermal states: description, preparation and reconstruction
Creators: name: Bogdanov, Yu. I.
name: Katamadze, K. G.
name: Avosopyants, G. V.
name: Belinsky, L. V.
name: Bogdanova, N. A.
name: Kalinkin, A. A.
name: Kulik, S. P.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a study of optical quantum states generated by subtraction of photons from the thermal state. Some aspects of their photon number and quadrature distributions are discussed and checked experimentally. We demonstrate an original method of up to ten photon subtracted state preparation with use of just one single-photon detector. All the states where measured with use of balanced homodyne technique, and the corresponding density matrices where reconstructed. The fidelity between desired and reconstructed states exceeds 99%
Mott transition and anomalous resistive state in the pyrochlore molybdates
Creators: name: Swain, Nyayabanta
name: Majumdar, Pinaki
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The rare-earth based pyrochlore molybdates involve orbitally degenerate electrons Hund's coupled to local moments. The large Hund's coupling promotes ferromagnetism, the superexchange between the local moments prefers antiferromagnetism, and Hubbard repulsion tries to open a Mott gap. The phase competition is tuned by the rare-earth ionic radius, decreasing which leads to change from a ferromagnetic metal to a spin disordered highly resistive ground state, and ultimately an 'Anderson-Mott' insulator. We attempt a quantitative theory of the molybdates by studying their minimal model on a pyrochlore geometry, using a static auxiliary field based Monte Carlo. We establish a thermal phase diagram that closely corresponds to the experiments, predict the hitherto unexplored orbital correlations, quantify and explain the origin of the anomalous resistivity, and present dynamical properties across the metal-insulator transition.
description: 6 pages with 5 figs
Eulichas milleri Ivie & Jach 2002
Creators: name: Hájek, Ji Ř Í
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Eulichadidae
Eulichas
Eulichas milleri

description: Eulichas milleri Ivie & Jäch, 2002
(Figs. 32, 48, 71)
Eulichas milleri Ivie & Jäch, 2002: 165 (original description, Vietnam: Hai Van Pass).
Type locality. “Hai Van Pass, 30 km north of Da Nang, Truong Son Mountains, central Vietnam ”.
Type material. Holotype ɗ (NHMW): “ VIETNAM: Da Nang / Hai Van Pass / UTM Coord. 937918 / 0 2 JUN 1970, blt / T. H. Dickens [printed] // R.S.Miller / Collection [printed] // HOLOTYPE / Eulichas / ɗ milleri / Ivie & Jäch [printed]”. Paratypes: 5 ɗɗ, same label data as holotype; 25 ɗɗ, same label data except “ 3 JUN 1970 ” (BMNH, FSCA, MTEC, NHMW [specimens from FSCA and MTEC were not studied]).
Description. Habitus elongate, fusiform. Body colouring brownish-red. Pale part of setation consists of recumbent yellowish setae forming typical ocellations on pronotum, elytra and abdominal sternites, where setae are darker and sparser (Fig. 71).
Measurements. Males: 25–28 mm (holotype 27 mm).
Head punctation consists of coarse setigerous punctures, larger and sparser on the frons, and smaller and denser on the vertex. Antenna robust, last antennomere ca. 2.10 times as long as wide (Fig. 48), its ventral side smooth with numerous small tubercles.
Pronotum largely transverse, ca. 2.25 times as wide as long, its sides almost regularly rounded with only indistinct angle near the middle. Punctation consists of moderately large and sparse setigerous punctures on the disc, and coarser and denser punctures laterally.
Elytra with numerous longitudinal rows of large setigerous punctures, and very fine interstitial punctures.
Ventral part with fine punctures, which are sparse medially and become larger and denser laterally. Last abdominal ventrite laterally regularly rounded to apex.
Male. Aedeagus with phallobase longer than parameres. Parameres complex, widened apically. Subbasal parameral hook developed, but subapical hook absent. Medio-ventral parameral process long, attenuating and acute distally. Median lobe slender and subparallel, apically slightly diverging (Fig. 32).
Female. Unknown.
Distribution. So far known only from the type locality in central Vietnam.
description: Published as part of Hájek, Ji Ř Í, 2007, Revision of the genus Eulichas Jacobson, 1913 (Coleoptera: Eulichadidae) I. Introduction, morphology of adults, key to subgenera and species groups, and taxonomy of E. funebris species group, pp. 1-35 in Zootaxa 1620 on pages 29-30, DOI: 10.5281/zenodo.179178
(200766) Charlotte Elizabeth Freer
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Analyse von Beweisprozessen von Studienanfänger/innen bei der Bearbeitung von Aufgaben zur Konvergenz von Folgen
Creators: name: Ostsieker, Laura
name: Biehler, Rolf
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2012
Subjects: subject: 510

description: Im Kompetenzzentrum Hochschuldidaktik Mathematik werden unter anderem Schwierigkeiten in der Studieneingangsphase untersucht. In einer explorativen (Vor-)Studie wurden Teilnehmer/innen der Vorlesung Analysis I in Kleingruppen bei der Bearbeitung von Aufgaben zur Konvergenz von Folgen beobachtet. Ein Schwerpunkt der Untersuchung ist die Analyse des Prozesses von der Ideenentwicklung über Rohentwürfe des Beweises zu einer "Reinschrift".
Eta-Eta' mixing and the derivative of the topological susceptibility at zero momentum transfer
Creators: name: Nasrallah, N. F.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The couplings of the isosinglet axial-vector currents to the Eta and Eta' mesons are evaluated in a stable, model independent way by use of polynomial kernels in dispersion integrals. The corrections to the Gell-Mann-Oakes-Renner relation in the isoscalar channel are deduced. The derivative of the topological susceptibility at the origin is calculated taking into account instantons and instanton screening.
description: Mistakes corrected. Text after eq.3.14 changed. An evaluation of the topological susceptibility itself is presented in addition
Wrinkling of a thin circular sheet bonded to a spherical substrate
Creators: name: Bella, Peter
name: Kohn, Robert V.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Analysis of PDEs (math.AP)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We consider a disk-shaped thin elastic sheet bonded to a compliant sphere. (Our sheet can slip along the sphere; the bonding controls only its normal displacement.) If the bonding is stiff (but not too stiff), the geometry of the sphere makes the sheet wrinkle to avoid azimuthal compression. The total energy of this system is the elastic energy of the sheet plus a (Winkler-type) substrate energy. Treating the thickness of the sheet $h$ as a small parameter, we determine the leading-order behavior of the energy as $h$ tends to zero, and give (almost matching) upper and lower bounds for the next-order correction. Our analysis of the leading-order behavior determines the macroscopic deformation of the sheet; in particular it determines the extent of the wrinkled region, and predicts the (nontrivial) radial strain of the sheet. The leading-order behavior also provides insight about the length scale of the wrinkling, showing that it must be approximately independent of the distance $r$ from the center of the sheet (so that the number of wrinkles must increase with $r$). Our results on the next-order correction provide insight about how the wrinkling pattern should vary with $r$. Roughly speaking, they suggest that the length scale of wrinkling should {\it not} be exactly constant -- rather, it should vary a bit, so that the number of wrinkles at radius $r$ can be approximately piecewise constant in its dependence on $r$, taking values that are integer multiples of $h^{-α}$ with $α\approx 1/2$.
description: 23 pages, 2 figures
title: Geometrie selbständig erarbeiten
title: Das Beispiel Strahlensätze
titleType: AlternativeTitle
Creators: name: Roth, Jürgen
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2012
Subjects: subject: 510

description: Am Beispiel der Geometrie wird mathematisches Denken und Arbeiten für Schüler besonders gut erlebbar. Ihr mathematisches Arbeiten kann hier sehr gut durch gegenständliche Modelle und Computersimulationen unterstützt werden. Im Mathematik-Labor Mathe ist mehr werden auf diese Weise Lehrplaninhalte selbständig erarbeitet und mit dem Unterricht im Klassenverband vernetzt. Ergebnisse einer Pilotstudie zum Thema Strahlensätze mit vier 9. Klassen werden berichtet.
(200768) Sarah Freer
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
On Support Relations and Semantic Scene Graphs
Creators: name: Yang, Michael Ying
name: Liao, Wentong
name: Ackermann, Hanno
name: Rosenhahn, Bodo
Publisher: name: arXiv
Year: 2016
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: Scene understanding is a popular and challenging topic in both computer vision and photogrammetry. Scene graph provides rich information for such scene understanding. This paper presents a novel approach to infer such relations and then to construct the scene graph. Support relations are estimated by considering important, previously ignored information: the physical stability and the prior support knowledge between object classes. In contrast to previous methods for extracting support relations, the proposed approach generates more accurate results, and does not require a pixel-wise semantic labeling of the scene. The semantic scene graph which describes all the contextual relations within the scene is constructed using this information. To evaluate the accuracy of these graphs, multiple different measures are formulated. The proposed algorithms are evaluated using the NYUv2 database. The results demonstrate that the inferred support relations are more precise than state-of-the-art. The scene graphs are compared against ground truth graphs.
description: Accepted in ISPRS Journal of Photogrammetry and Remote Sensing
Parragil / Gilvrasino: um exercício toponímico
Creators: name: Sousa, Aníbal de
Publisher: name: figshare
Year: 2023
Subjects: Other human society not elsewhere classified

description: Se por um lado, os topónimos Gilvrasino e Parragil conflituam, por outro identificam uma constelação de sítios e lugares que vão progressivamente mudando de nome, merecendo atenção também o que se passa com os lugares de Nora dos Velhos e Cerro Alto, com relação a Soalheira, Varjota e Palmeiral.
Additional file 3 of A multi-phase approach for developing a conceptual model for human resources for health observatory (HRHO) toward integrating data and evidence: a case study of Iran
Creators: name: Najafpour, Zhila
name: Arab, Mohammad
name: Shayanfard, Kamran
Publisher: name: figshare
Year: 2023
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences

description: Additional file 3. Model validation phase.
Molecular docking and molecular dynamic simulations of apoptosis proteins with potential anticancer compounds present in Clinacanthus nutans extract using gas chromatography–mass spectrometry
Creators: name: Ismail, Noor Zafirah
name: Mohamed, Wan Ahmad Syazani
name: Rahim, Nurhidayah Ab.
name: Hashim, Nor Munira
name: Adebayo, Ismail Abiola
name: Zain, Nur Nadhirah Mohamad
name: Arsad, Hasni
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Clinacanthus nutans is a medicinal plant recognised for its anticancer properties. We previously discovered that the C. nutans extract had the most potent inhibitory effect on MCF7 breast cancer cell and significantly induced apoptosis. However, there is a scarcity of studies demonstrating the molecular interactions of C. nutans-derived chemical compounds associated with apoptosis-related proteins. Therefore, the objective of this study was to determine the potential chemical compounds found in the C. nutans extract and examine their interactions with the targeted apoptotic proteins using molecular docking and molecular dynamic simulations. To address this objective, the compounds found in the SF2 extract of C. nutans were analysed using Gas Chromatography-Mass Spectrometry (GC-MS). The molecular interaction of the compounds with the targeted apoptotic proteins were determined using molecular docking and molecular dynamic simulations. GC-MS analysis revealed a total of 32 compounds in the SF2 extract. Molecular docking analysis showed that compound β-amyrenol had the highest binding affinity for MDM2-P53 (−7.26 kcal/mol), BCL2 (−11.14 kcal/mol), MCL1-BAX (−6.42 kcal/mol), MCL1-BID (−6.91 kcal/mol), and caspase-9 (−12.54 kcal/mol), whereas campesterol had the highest binding affinity for caspase-8 (−10.11 kcal/mol) and caspase-3 (−10.14 kcal/mol). These selected compounds were subjected to molecular dynamic simulation at 310 K for 100 ns. The results showed that the selected protein-ligand conformation complexes were stable, compact, and did not alter much when compared to the protein references. The findings indicate that β-amyrenol and campesterol are potentially significant compounds that might provide insight into the molecular interactions of the compounds with the apoptosis-related proteins. Communicated by Ramaswamy H. Sarma
CARBON AND COKE REACTIVITY IN ZINC-LEAD BLAST FURNACE PRACTICE
Creators: name: CARTER, Margaret Ann
Publisher: name: University of Plymouth
Year: 1983

description: Previous research on the oxidation of coke in air, O2 and CO2 has been reviewed, especially with regard to kinetic studies and Zn/Pb blast furnace practice. Coke "reactivity" has been discussed and correlated with surface area changes on carbon burn-off (in air and CO2 at various temperatures) for Nauitgarw and two other metallurgical cokes. Other carbons (charcoals and graphite) and a-brovnr. coal char~ have been examined by gas sorption, X ray diffraction and thermal analysis in an attempt to relate reactivity, as determined by rate of reaction in CO2 at 1000°C, with other solid state properties. Reactivity studies on coal chars have been reviewed also. The inhibition of the Boudouard reaction, by modification of the carbon surface, has been reviewed, especially by the action of'B203. Cokes and coal char have been subject to B2O3 solution treatment and the mode of action of the inhibitor investigated by isothermal and dynamic thermal analysis and estimation of surface area by gravimetric gas sorption. The action of B2O3 at both low and high degree of carbon burn o f f has been studied. The mineral matter of coke (which forms about 10% by weight of the material) and the coal char (which forms about 2%) has been examined by X ray diffraction , optical and electron microscopy and thermal and chemical analysis. Its affect upon the kinetics of oxidation has been investigated. Results have been discussed in relation to the industrial usage of coke in the Zn/Pb blast furnace.
Relative response of metabolites to hours and days of heat stress in a tree species Polyscias elegans
Creators: name: Zhu, Lingling
name: Atkin, Owen
name: Andrew P., Scafaro
name: Elizabeth, Vierling
name: Marilyn C., Ball
name: Bradley C., Posch
name: Frederike, Stock
Publisher: name: The Australian National University Data Commons'
Year: 2023

description: Tropical-subtropical rainforest tree species Polyscias elegans were heated at 40 ºC for five days, before returning to 25 ºC for 13 days of recovery. Leaf metabolites were quantified in hours and days of heat stres. The analysis of metabolites involved extraction, derivatization, and GC/MS (Gas Chromatography Mass Spectrometry, 7890A GC system, 5957 inert XL EI/CI MSD, Agilent technologies, USA) analysis in the Joint Mass Spectrometry Facility of Australia National University.
Additional file 4 of Lesions and pathogens found in pigs that died during the nursery period in five Danish farms
Creators: name: Barington, Kristiane
name: Eriksen, Esben Østergaard
name: Kudirkiene, Egle
name: Pankoke, Karen
name: Hartmann, Katrine Top
name: Hansen, Mette Sif
name: Jensen, Henrik Elvang
name: Blirup-Plum, Sophie Amalie
name: Jørgensen, Benjamin Meyer
name: Nielsen, Jens Peter
name: Olsen, John Elmerdahl
name: Goecke, Nicole Bakkegård
name: Larsen, Lars Erik
name: Pedersen, Ken Steen
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 4: Number of pigs per herd from which tissue from organs/tissues were sampled and histologically evaluated. File format:.docx.
Eulichas mediocris
Creators: name: Hájek, Ji Ř Í
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Eulichadidae
Eulichas
Eulichas mediocris

description: The Eulichas mediocris species complex
The complex comprises two species from Sumatra and surrounding small islands, which should be characterised by the pronotum with sides subbasally parallel, or slightly incised with hind angles prominent. Last antennomere almost rectangular, not distinctly widened. Parameres with subbasal hook developed, but the subapical hook is absent. Body length relatively small (males: 14–19 mm, females: 19–26 mm).
description: Published as part of Hájek, Ji Ř Í, 2007, Revision of the genus Eulichas Jacobson, 1913 (Coleoptera: Eulichadidae) I. Introduction, morphology of adults, key to subgenera and species groups, and taxonomy of E. funebris species group, pp. 1-35 in Zootaxa 1620 on page 30, DOI: 10.5281/zenodo.179178
Human TMPRSS2 non-catalytic ectodomain and SARS-CoV-2 S2' subunit interaction mediated SARS-CoV-2 endocytosis: a model proposal with virtual screening for potential drug molecules to inhibit this interaction
Creators: name: Konduru, Guruprasad Varma
name: Nagarajaram, Hampapathalu Adimurthy
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
classificationCode: 59999
subject: Environmental Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Cancer
classificationCode: 111714
subject: Mental Health
classificationCode: 60506
subject: Virology

description: This study proposes a novel model for integration of SARS-CoV-2 into host cell via endocytosis as a possible alternative to the prevailing direct fusion model. It is known that the SARS-CoV-2 spike protein undergoes proteolytic cleavage at S1-S2 cleavage site and the cleaved S2 domain is primed by the activated serine protease domain (SPD) of humanTMPRSS2 to become S2'. The activated SPD of TMPRSS2 is formed after it is cleaved by autocatalysis from the membrane bound non-catalytic ectodomain (hNECD) comprising of LDLRA CLASS-I repeat and a SRCR domain. It is known that the SRCR domains as well as LDLRA repeat harboring proteins mediate endocytosis of viruses and certain ligands. Based on this, we put forward a hypothesis that the exposed hNECD binds to the S2' as both are at an interaction proximity soon after S2 is processed by the SPD and this interaction may lead to the endocytosis of virus. Based on this hypothesis we have modelled the hNECD structure, followed by docking studies with the known 3D structure of S2'. The interaction interface of hNECD with S2’ was further used for virtual screening of FDA-approved drug molecules and Indian medicinal plant-based compounds. We also mapped the known mutations of concern and mutations of interest on interaction interface of S2’ and found that none of the known mutations map onto the interaction interface. This indicates that targeting the interaction between the hNECD of TMPRSS2 and S2’ may serve as an attractive therapeutic target. Communicated by Ramaswamy H. Sarma
Weak prediction principles
Creators: name: Ben-Neria, Omer
name: Garti, Shimon
name: Hayut, Yair
Publisher: name: arXiv
Year: 2016
Subjects: subject: Logic (math.LO)
subject: FOS: Mathematics
subject: 03E05

description: We prove the consistency of the failure of the weak diamond $Φ_λ$ at strongly inaccessible cardinals. On the other hand, we show that the very weak diamond $Ψ_λ$ is equivalent to the statement $2^{
Human CD34+ hematopoietic stem cell hierarchy: how far are we with its delineation at the most primitive level?
Creators: name: Anjos-Afonso, Fernando
name: Bonnet, Dominique
Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: Stem Cells
Human Biology & Physiology
Tumour Biology

description: The ability to isolate and characterize different HSPC (hematopoietic stem/progenitor cell) populations opens avenues to understand how hematopoiesis is regulated during development, homeostasis and regeneration, as well as in age-related conditions such as clonal hematopoiesis and leukemogenesis. Significant progress has been made in the past few decades in determining the composition of the cell types that exist in this system, but the most significant advances have come from mouse studies. However, recent breakthroughs have made significant strides that have enhanced the resolution of the human primitive hematopoietic compartment. Therefore, we aim to review this subject not only from a historical perspective but also to discuss the progress made in the characterization of the human post-natal CD34+ HSC-enriched populations. This approach will enable us to shed light on the potential future translational applicability of human HSCs.
(200763) Annie Wrightson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The effect of rehabilitation programs on multidirectional instability of the glenohumeral joint
Creators: name: Warby, Sarah Ann
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the Department of Rehabilitation, Nutrition and Sport, School of Allied Health, College of Science, Health and Engineering, La Trobe University, Bundoora.

Thesis with publications.

This thesis was a recipient of the Nancy Millis Award for theses of exceptional merit.
Highly tunable time-reversal-invariant topological superconductivity in topological insulator thin films
Creators: name: Parhizgar, Fariborz
name: Black-Schaffer, Annica M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We study time-reversal-invariant topological superconductivity in topological insulator (TI) thin films including both intra- and inter-surface pairing. We find a nontrivial topology for multiple different configurations. For intra-surface pairing a $π$-phase difference between the intra-surface pairing states is required. We show that in this case the resulting topological phase is highly tunable by both an applied electric field and varied chemical potential. For spin-singlet inter-surface pairing, a sign-changing tunnel coupling present in many TI thin films is needed, and again, the topology can be tuned by electric field or doping. Notably, we find that the required inter-surface pairing strength for achieving nontrivial topology can still be subdominant compared to the intra-surface pairing. Finally, for spin-triplet inter-surface pairing we prove that the superconducting state is always topological nontrivial. We show that thin films of Cu-doped Bi$_2$Se$_3$ will likely host such spin-triplet inter-surface pairing. Taken together, these results show that time-reversal-invariant topological superconductivity is common in superconducting TI thin films and that the topological phase and its Kramers pair of Majorana edge modes is highly tunable with an applied electric field and varied chemical potential.
description: 10 pages, 6 figures
title: Von der Schwierigkeit, Leistung zu steigern
title: Innovationen zu Beginn des Mathematik-Lehramtsstudiums
titleType: AlternativeTitle
Creators: name: Schreiber, Stephan
name: Fischer, Elisabeth
name: Biehler, Rolf
name: Hänze, Martin
name: Hochmuth, Reinhard
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2012
Subjects: subject: 510

description: Das Projekt LIMA ist ein Gemeinschaftsprojekt der Universitäten Paderborn und Kassel. Zentrale Komponenten des Projekts sind die Entwicklung und Implementierung von Lehrinnovationen zu Beginn des Mathematikstudiums für Lehramt und eine empirische Begleitstudie. Forschungsansatz und -ziele werden skizziert und Teilergebnisse der Studie berichtet. Im Zentrum steht der Zusammenhang zwischen Lehrinnovation und individuellen Merkmalen sowie der fachlichen Leistungsentwicklung der Studierenden.
Additional file 1 of A comprehensive map of human glucokinase variant activity
Creators: name: Gersing, Sarah
name: Cagiada, Matteo
name: Gebbia, Marinella
name: Gjesing, Anette P.
name: Coté, Atina G.
name: Seesankar, Gireesh
name: Li, Roujia
name: Tabet, Daniel
name: Weile, Jochen
name: Stein, Amelie
name: Gloyn, Anna L.
name: Hansen, Torben
name: Roth, Frederick P.
name: Lindorff-Larsen, Kresten
name: Hartmann-Petersen, Rasmus
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 1: Fig. S1. Expression of GCK variants. Fig. S2. Co-expression of GKRP and GCK. Fig. S3. Imputed map of glucokinase variant activity. Fig. S4. Activity scores mapped onto GCK ribbon diagram. Fig. S5. Evolutionary analysis of GCK homologous sequences. Fig. S6. Correlations between evolutionary conservation and activity scores. Fig. S7. Rosetta ΔΔG heatmaps. Fig. S8. Positions predicted to shift GCK towards the closed conformation are enriched at the allosteric activator site.Please check additional files if captured correctly.Error during converting author query response. Please check the eproofing link or feedback pdf for details
Modeling and computational characterization of a Xanthomonas sp. Hypothetical protein identifies a remote ortholog of Burkholderia lethal factor 1
Creators: name: Ismail, Nur Afiqah Shalihin Muhamad
name: Yap, Su Hui
name: Yussoff, Mohamad Ariff Mohamad
name: Muhammad, Nor Azlan Nor
name: Firdaus-Raih, Mohd
name: Quay, Doris Huai Xia
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
classificationCode: 80699
subject: Information Systems not elsewhere classified
classificationCode: 110309
subject: Infectious Diseases
subject: FOS: Health sciences

description: Burkholderia Lethal Factor 1 (BLF1) is a deamidase first characterized in Burkholderia pseudomallei. This enzyme inhibits cellular protein synthesis by deamidating a glutamine residue to a glutamic acid in its target protein, the eukaryotic translation initiation factor 4 A (eIF4A). In this work, we present the characterization of a hypothetical protein from Xanthomonas sp. Leaf131 as the first report of a BLF1 family ortholog outside of the Burkholderia genus. Although standard sequence similarity searches such as BLAST were not able to detect the homology between the Xanthomonas sp. Leaf131 hypothetical protein sequence and BLF1, our computed structure model for the Xanthomonas sp. hypothetical protein revealed structural similarities with an RMSD of 2.7 Å/164 Cα atoms and a TM-score of 0.72 when superposed. Structural comparisons of the Xanthomonas model structure against BLF1 and Escherichia coli cytotoxic necrotizing factor 1 (CNF1) revealed that the conserved signature LXGC motif and putative catalytic residues are structurally aligned thus signifying a level of functional or mechanistic similarity. Protein-protein docking analysis and molecular dynamics simulations also demonstrated that eIF4A could still be a possible target substrate for deamidation by XLF1 as it is for BLF1. We therefore propose that this Xanthomonas hypothetical protein be renamed as Xanthomonas Lethal Factor 1 (XLF1). Our work also provides further evidence of the utility of programs such as AlphaFold in bridging the computational function annotation transfer gap despite very low sequence identities of under 20%. Communicated by Ramaswamy H. Sarma
(200764) Adeline Louisa Freer
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Human TMPRSS2 non-catalytic ectodomain and SARS-CoV-2 S2' subunit interaction mediated SARS-CoV-2 endocytosis: a model proposal with virtual screening for potential drug molecules to inhibit this interaction
Creators: name: Konduru, Guruprasad Varma
name: Nagarajaram, Hampapathalu Adimurthy
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
classificationCode: 59999
subject: Environmental Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Cancer
classificationCode: 111714
subject: Mental Health
classificationCode: 60506
subject: Virology

description: This study proposes a novel model for integration of SARS-CoV-2 into host cell via endocytosis as a possible alternative to the prevailing direct fusion model. It is known that the SARS-CoV-2 spike protein undergoes proteolytic cleavage at S1-S2 cleavage site and the cleaved S2 domain is primed by the activated serine protease domain (SPD) of humanTMPRSS2 to become S2'. The activated SPD of TMPRSS2 is formed after it is cleaved by autocatalysis from the membrane bound non-catalytic ectodomain (hNECD) comprising of LDLRA CLASS-I repeat and a SRCR domain. It is known that the SRCR domains as well as LDLRA repeat harboring proteins mediate endocytosis of viruses and certain ligands. Based on this, we put forward a hypothesis that the exposed hNECD binds to the S2' as both are at an interaction proximity soon after S2 is processed by the SPD and this interaction may lead to the endocytosis of virus. Based on this hypothesis we have modelled the hNECD structure, followed by docking studies with the known 3D structure of S2'. The interaction interface of hNECD with S2’ was further used for virtual screening of FDA-approved drug molecules and Indian medicinal plant-based compounds. We also mapped the known mutations of concern and mutations of interest on interaction interface of S2’ and found that none of the known mutations map onto the interaction interface. This indicates that targeting the interaction between the hNECD of TMPRSS2 and S2’ may serve as an attractive therapeutic target. Communicated by Ramaswamy H. Sarma
Women, witness and trauma: writing selves
Creators: name: Keighran, Judyth
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy (Creative Writing) to the Department of Creative Arts and English, School of Humanities and Social Sciences, College of Arts, Social Science and Commerce, La Trobe University, Bundoora.
Functional Fit Approach (FFA) for Density of States method: SU(3) spin system and SU(3) lattice gauge theory with static color sources
Creators: name: Giuliani, Mario
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We apply a recently developed variant of the Density of States (DoS) method, the so-called Functional Fit Approach (FFA) to two different models: the SU(3) spin model and SU(3) lattice gauge theory with static color sources. Both models can be derived from QCD and inherit the complex action problem at finite density. We discuss the implementation of DoS FFA in the two models and compute observables related to the particle density. For the SU(3) spin model we show that the results are in good agreement with the results from a Monte Carlo simulation in the dual formulation, which is free of the complex action problem. For the case of SU(3) lattice gauge theory with static color sources we present first results for the particle number as a function of the coupling for different values of the chemical potential.
Mathematiklernen im Kindergarten in formal offenen Situationen
Creators: name: Schuler, Stephanie
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2012
Subjects: subject: 510

description: Mit gezielt ausgewählten Spielen können zahlreiche mathematische Lerngelegenheiten entstehen. Deren Auftreten ist abhängig vom mathematischen Potenzial der Spiele und insbesondere von der Gestaltung der Spielsituation durch die Erzieherin. Die Analyse von Spielsituationen mit Methoden der Videographie und der Grounded Theory zeigt die Herausforderungen für die im Kontext der formalen Offenheit handelnden Erzieherinnen auf. Im Vortrag werden die Ergebnisse der abgeschlossenen Videostudie vorgestellt.
Synthesis and Studies of Rhenium and Technetium Complexes of N-Heterocyclic Carbene Ligands
Creators: name: Chan, Chung Ying
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted for the degree of Doctor of philosophy in Chemistry to the Department of Chemistry and Physics, School of Molecular Sciences, College of Science, Health and Engineering, La Trobe University, Bundoora.
Design, synthesis, extra-precision docking, and molecular dynamics simulation studies of pyrrolidin-2-one derivatives as potential acetylcholinesterase inhibitors
Creators: name: Gupta, Mohan
name: Kumar, Avinash
name: Prasun, Chakrawarti
name: Nair, Maya S.
name: Kini, Suvarna G.
name: Yadav, Divya
name: Nain, Sumitra
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
classificationCode: 80699
subject: Information Systems not elsewhere classified

description: Inhibition of acetylcholinesterase (AChE) has been widely explored to develop novel molecules for management of Alzheimer's disease. In past research finding reported molecule 3-(4-(4-fluorobenzoyl)piperidin-1-yl)-1-(4-methoxybenzyl)pyrrolidin-2-one displayed a spectrum of anti-Alzheimer’s properties herein, we report a library of 18 novel molecules that were rationally designed and synthesized employing known literature to mimic and explore the novel chemical space around the lead compound 6e and donepezil. All the compounds were docked in extra-precision mode with AChE (PDB ID 4EY7) using the Glide module. Molecular dynamics (MD) simulation studies were carried out for 100 ns along with MM-PBSA studies of the trajectory frames generated post-MD simulations. Docking and MD simulation studies suggested that the synthesized compounds showed a good binding affinity with AChE. and might form stable complexes. 3-(4-(benzyl(methyl)amino)piperidin-1-yl)-1-(3,4-dimethoxybenzyl)pyrrolidin-2-one (14a; docking score: −18.59) and 1-(3,4-dimethoxybenzyl)-3-(4-(methyl(thiazol-2-ylmethyl)amino)piperidin-1-yl)pyrrolidin-2-one (14d; docking score: −18.057) showed higher docking score than donepezil (docking score: −17.257) while most of the compounds had docking score >-10.0. ADMET study predicted these compounds to be CNS active and most of the compounds were drug-like molecules with no HERG blockade and good to excellent oral absorption. We developed an atom-based 3 D-QSAR model with R^2 and Q^2 values of 0.9639 and 0.8779 to predict the activity of the synthesized compounds. The model predicted these compounds to be potent AChE inhibitors with IC50 values in the lower micromolar range. Based on the in silico findings, we report these newly synthesized compounds 3-(4-(benzyl(methyl)amino)piperidin-1-yl)-1-(3,4-dimethoxybenzyl)pyrrolidin-2-one (14a) and 7-(2,6-difluorobenzyl)-2-(4-methoxybenzyl)-2,7-diazaspiro[4.5]decan-1-one (20 b) as potential AChE inhibitors. Communicated by Ramaswamy H. Sarma
Amtliche Mitteilungen der Universität Dortmund Nr. 07/82
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Dortmund
Year: 1982
Subjects: subject: 080

description: Änderung Geschäftsordnung des Senats der Universität Dortmund
description: Orientierungsphase für Studienanfänger
description: Amtliche Mitteilungen der Universität Dortmund ; 7, 1982
Anyon Chains with Pairing Terms
Creators: name: Garjani, B. Majidzadeh
name: Ardonne, E.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: In this paper we introduce a one-dimensional model of $su(2)_k$ anyons in which the number of anyons can fluctuate by means of a pairing term. The model can be tuned to a point at which one can determine the exact zero-energy ground states, in close analogy to the spin-1 AKLT model. We also determine the points at which the model is integrable and determine the behavior of the model at these integrable points.
description: 30 pages
Understanding novel aspects of bone metabolism and fracture healing
Creators: name: Brady, Rhys
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the Department of Physiology, Anatomy and Microbiology, School of Life Sciences, College of Science, Health and Engineering, La Trobe University, Bundoora.
iPort und PiCarta als Basis für individuelle Bibliotheksportale
Creators: name: Diedrichs, Reiner
Publisher: name: Universität Dortmund
Year: 2002
Subjects: subject: 020

description: Portale und Suchmaschinen sind heute unverzichtbarer Bestandteil der Informationsangebote der Bibliotheken und Verbundsysteme. Suchmaschinen erlauben es, nahezu beliebige Datenbanken in eine parallele Suche einzubeziehen. Die einfache Handhabung dieser Technologie führte dazu, dass aufwendige Indexierungstechniken und die Zusammenführung von Datenbanken, wie sie für traditionelle Verbunddatenbanken typisch ist, als nicht mehr zeitgemäß angesehen wurden und die Zukunft allen den Suchmaschinen gehörte. Der Einsatz von Suchmaschinen in der Praxis zeigt jedoch Probleme auf, die das Konzept der Datenintegration in einer Datenbank mit homogener und effizienter Indexierung in vielen Fällen als die bessere Lösung erscheinen läst. OCLC|PICA trägt mit der Entwicklung von iPort als Suchmaschine und der konsequenten Weiterentwicklung von PiCarta für die Integration verschiedener Verbund- und Bibliotheksdatenbanken in einer Datenbank den Anforderungen nach Vernetzbarkeit auf der einen und nach effizienten Suchmechanismen auf der andere Seite Rechnung. Eine Suchmaschine ist noch kein Bibliotheksportal. Zu einer Portallösung gehören eine Reihe von integrierten Dienstleitungen: Dokumentlieferdienste und Fernleihe, SDI-Services, Zeitschrifteninhaltsdienste, Selbstbedienungsfunktionen für Verlängerungen am OPAC, Lizenzüberwachung für elektronische Zeitschriften, dynamisches Linkmanagement, usw. Aufbauend auf einer kurzen Darstellung der Architektur von iPort und PiCarta wird das Konzept für den Einsatz von bibliotheksspezifischen Portallösungen im GBV vorgestellt und am Beispiel des Verbund- und eines Bibliotheksportales erläutert.
(200761) Jane Blaber
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.