The fate and function of non-coding RNAs during necroptosis
Creators: name: Bozgeyik, Esra
name: Elek, Alperen
name: Gocer, Zekihan
name: Bozgeyik, Ibrahim
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Developmental Biology
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Necroptosis is a novel form of cell death which is activated when apoptotic cell death signals are disrupted. Accumulating body of observations suggests that noncoding RNAs, which are the lately discovered mystery of the human genome, are significantly associated with necroptotic signaling circuitry. The fate and function of miRNAs have been well documented in human disease, especially cancer. Recently, lncRNAs have gained much attention due to their diverse regulatory functions. Although available studies are currently based on bioinformatic analysis, predicted interactions desires further attention, as these hold significant promise and should not be overlooked. In the light of these, here we comprehensively review and discuss noncoding RNA molecules that play significant roles during execution of necroptotic cell death. Necroptosis is a novel form of cell death triggered by disrupted apoptotic signals. noncoding RNAs, a mystery of the human genome, are significantly associated with necroptotic signaling. Their diverse regulatory functions, particularly in cancer, warrant further attention due to their potential. Necroptosis is morphologically characterized by swelling and rupture of plasma membrane, and uncontrolled release of intracellular milieu. Necroptosis was first described by the inhibition of receptor-interacting protein kinase 1 (RIPK1) with particular pharmacological inhibitors such as necrostatin-1. RIPK1, receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-Like (MLKL), are serine/threonine kinases constituting key components of the necroptotic signaling pathway. Necroptosis is induced in cells lacking adequate apoptotic signaling. The discovery of the noncoding RNA molecules has revolutionized our understanding of cell biology. Cumulative evidence suggests that miRNAs, lncRNAs and other types of noncoding RNAs play fundamental roles in the regulation of cell death mechanisms including necroptosis. MicroRNAs (miRNAs) are small RNA molecules that function by binding to the 3′-untranslated region (3′-UTR) regions of mRNAs, leading either inhibition of protein synthesis or degradation of their target mRNAs. Growing evidence indicates that miRNAs participate in the regulation of necroptosis. Several molecular mechanisms such as chromatin remodeling, genetic imprinting, splicing, mRNA translation and decay have been shown to be under the control of lncRNAs. PACER is identified to be significant modulator of necroptotic cell death in colon cancer. LncRNA molecules seems to be key components of necroptotic death signaling.