cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Discovery of serum markers of lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The detection of cancer markers in serum can provide early diagnosis, monitoring of the effectiveness of therapy, and detection of early recurrence. The prostate-specific antigen (PSA) is a prime example of the power of serum tumor markers. The PSA has markedly enhanced our abilities to screen and monitor patients with prostate cancer. The principals concerning PSA can also apply to lung cancers where a critical lack of serum markers decreases the ability of physicians to manage these patients. Our research will provide a novel and rapid method to look for new proteins which can be used as serum markers of lung cancer. These markers will enable early cancer detection or early relapse, and guidance in choosing effective therapy for lung cancer.

 Our allows us to screen for genes that produce lung cancer-specific proteins which are secreted out of the cell. Once we have assured ourselves that we have indeed isolated lung cancer-specific, secreted proteins, we will determine if individuals with lung cancer have these proteins circulating in their bloodstream. If indeed they do, we will test a large collection of sera from individuals with early and late lung cancer to determine how specific and sensitive our newly identified proteins are as serum markers of lung cancer. Also, as a by-product of this research, we may find that these newly discovered proteins, in addition to being markers for lung cancer, may have unique functions that teach us fundamentals of lung cancer.
Morulina verrucosa Borner 1903
Creators: name: Mayvan, Mahmood Mehrafrooz
name: Greenslade, Penelope
name: Sadeghi-Namaghi, Hussein
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Poduromorpha
Neanuridae
Morulina
Morulina verrucosa

description: Morulina verrucosa Börner, 1903
– Neanura verrucosa B̂rner, 1903: 136.
GI: Daghighi 2012.
Ecology and habitat in Iran: soil.
General distribution: Central Europe (Dányi & Traser 2008).
description: Published as part of Mayvan, Mahmood Mehrafrooz, Greenslade, Penelope & Sadeghi-Namaghi, Hussein, 2023, An annotated checklist of the Collembola (Hexapoda) from Iran, pp. 1-101 in Zootaxa 5275 (1) on page 27, DOI: 10.11646/zootaxa.5275.1.1, http://zenodo.org/record/7898948
Bilobella aurantiaca
Creators: name: Mayvan, Mahmood Mehrafrooz
name: Greenslade, Penelope
name: Sadeghi-Namaghi, Hussein
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Poduromorpha
Neanuridae
Bilobella
Bilobella aurantiaca

description: Bilobella aurantiaca (Caroli, 1912)
– Achorutes aurantiacus Caroli, 1912: 367.
CE, TE, MAZ, GI, EA: Cox 1982; Yoosefi Lafooraki & Shayanmehr 2015a.
Ecology and habitat in Iran: soil.
Remarks: Cox (1982), Daghighi et al. (2013a) and Falahati et al. (2013a) mentioned this species as Neanura aurantiaca but in the last generic combination it is considered as Bilobella aurantiaca.
General distribution: Palaearctic (Dányi & Traser 2008; Thibaud 2017; Bendjaballah et al. 2018).
Genus Cryptonura Cassagnau, 1979
description: Published as part of Mayvan, Mahmood Mehrafrooz, Greenslade, Penelope & Sadeghi-Namaghi, Hussein, 2023, An annotated checklist of the Collembola (Hexapoda) from Iran, pp. 1-101 in Zootaxa 5275 (1) on page 27, DOI: 10.11646/zootaxa.5275.1.1, http://zenodo.org/record/7898948
Isolation of lung tumor proteins for a novel treatment
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Due to the prevalence of smoking, lung cancer is now the leading cause of death from cancer in the United States. The proportion of tobacco-derived cancers classified as nonsmall cell lung cancer (NSCLC) is increasing and now outnumbers other histological subtypes. Whereas chemotherapy for the other main type of smoking-associated cancer (small cell lung cancer) can be effective, the current therapy for NSCLC has limited effectiveness. In part, this is because many patients with NSCLC have metastasis (tumor has spread to other sites in the body) and often have recurring cancer after the initial treatment.

 Illudins are natural products with a novel chemical structure isolated from the toxic Jack O' Lantern mushroom, which grows throughout California. The mushroom received its unusual name because it glows in the dark in the fall. Our laboratory has been developing novel chemotherapeutic agents from these Illudin toxins for treatment of NSCLC. During the past 3 years, with support from the TRDRP, we accomplished the following in developing a novel chemotherapeutic agent for NSCLC:

 (1) We developed a class of Illudin-like compounds, Acylfulvenes, with improved effectiveness against NSCLC, including those resistant to other drugs.

 (2) We used a screening model to identify a lead candidate known as HMAF (MGI-114) for initial trials in humans.

 (3) We obtained sponsorship, using these data, for human trials of our lead agent HMAF which are currently in progress. In addition, based on promising results from the initial human trial, the National Cancer Institute has agreed to sponsor up to 11 follow-up trials at various Cancer Centers throughout the United States.

 Despite the marked success of our project, there currently remains considerable work to complete. We need to identify the nature of the proteins located on the surface of lung tumor cells which permit the rapid entry of Illudins into these cancer cells. Identification of these lung cancer proteins will allow the use of advanced techniques of drug design, such as computer modeling, to design Illudin-like compounds with improved anticancer activity. Basic knowledge about expression of these proteins in lung cancer will also provide insight into how and why these cancers develop.
Zosimus aeneus
Creators: name: Devi, S. Suvarna
name: Mendoza, Jose C. E.
name: Ravinesh, R.
name: Idress Babu, K. K.
name: Kumar, A. Biju
name: Ng, Peter K. L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Xanthidae
Zosimus
Zosimus aeneus

description: Zosimus aeneus (Linnaeus, 1758)
Material examined. 2 males (45.9 x 30.5 mm, 67.6 x 45.7 mm) (DABFUK), Kavaratti, 8 January 2013; 2 males (30.8 x 20.9 mm, 43.5 x 29.8 mm) (DABFUK), Kadamat, 20 June 2013; 1 male (31.3 x 21.7 mm), 1 female (66.6 x 44.3 mm) (DABFUK), Minicoy, 25 September 2014; 2 females (41.9 x 20.4 mm, 51.2 x 39.8 mm) (DABFUK), Kilton, 19 October 2014; 2 females (52.6 x 33.5 mm, 65.8 x 44.3 mm) (DABFUK), Kalpeni, 2 October 2014; 1 juvenile male (13.8 x 9.4 mm) (DABFUK), Kavaratti, 17 November 2015.
Remarks. Previously recorded from Lakshadweep (Alcock 1898; Thomas 1969; Suvarna Devi et al. 2014; Kumaralingam et al. 2017). This is a common poisonous species widespread in the Indo-West Pacific (Serène 1984).
description: Published as part of Devi, S. Suvarna, Mendoza, Jose C. E., Ravinesh, R., Idress Babu, K. K., Kumar, A. Biju & Ng, Peter K. L., 2019, On a collection of brachyuran crabs from Lakshadweep, Indian Ocean (Crustacea: Decapoda: Brachyura), pp. 477-501 in Zootaxa 4613 (3) on page 489, DOI: 10.11646/zootaxa.4613.3.4, http://zenodo.org/record/3239869
Site remediation program, site status report; Fall 1992
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1992

description: The "Site Remediation Program Site Status Report" contains the more environmentally complex sites being remediated under New Jersey's Site Remediation Program. It does not reflect all remedial activities being conducted throughout the state. Rather, the report contains those sites where there are multiple sources of contamination; multiple environmental media affected (i.e. soil, ground water and air); multiple contaminants; and/or a multi-phased approach is being applied (investigation, design, construction and/or operation and maintenance) to clean up the site.This document includes descriptions of all Superfund (National Priority List-NPL) sites in New Jersey, both publicly and privately funded; the more complex Environmental Cleanup Responsibility Act (ECRA) Program cases; major cases overseen by the Division of Privately Funded Site Remediation's Responsible Party Cleanup Program and other non-superfund publicly funded sites. The site descriptions are grouped together by county. Each county section begins with a listing of all sites in that county in alphabetical order, with a corresponding map which identifies the major roadways and shows the location of each site.
Cardisoma carnifex
Creators: name: Devi, S. Suvarna
name: Mendoza, Jose C. E.
name: Ravinesh, R.
name: Idress Babu, K. K.
name: Kumar, A. Biju
name: Ng, Peter K. L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Gecarcinidae
Cardisoma
Cardisoma carnifex

description: Cardisoma carnifex (Herbst, 1796)
Material examined. 1 female (35.1 x 42.9 mm) (DABFUK), Minicoy, 17 August 2013.
Remarks. Previously recorded from Lakshadweep (Thomas 1969). This is the most widely distributed gecarcinid species in the Indo-West Pacific (Türkay 1974), and is the only one known from the western Indian Ocean.
description: Published as part of Devi, S. Suvarna, Mendoza, Jose C. E., Ravinesh, R., Idress Babu, K. K., Kumar, A. Biju & Ng, Peter K. L., 2019, On a collection of brachyuran crabs from Lakshadweep, Indian Ocean (Crustacea: Decapoda: Brachyura), pp. 477-501 in Zootaxa 4613 (3) on page 489, DOI: 10.11646/zootaxa.4613.3.4, http://zenodo.org/record/3239869
Additional file 1: of Nuclear Wiskottâ  Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells
Creators: name: Kuznetsov, Nikolai
name: Bader Almuzzaini
name: Kritikou, Joanna
name: Baptista, Marisa
name: Oliveira, Mariana
name: Marton Keszei
name: Snapper, Scott
name: Percipalle, Piergiorgio
name: Westerberg, Lisa
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Supplementary Figures S1â  S7. (PDF 1766 kb)
Dissecting signaling pathways to test cancer-killing agents
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: A variety of anticancer agents have been noted to be less effective in killing tumor cells than otherwise expected. Recently, this reduced effectiveness has been suggested to result from the anticancer agent-induced activation of transcription factors of the NF-kB family, which form key components of a primary signal transduction pathway (i.e., a cellular messaging system). Activation of transcription factor NF-kB has been shown to prevent programmed cell death, a biological pathway by which many anticancer agents kill tumor cells. Therefore, inhibiting NF-kB activity may increase the effectiveness of certain cancer-killing agents. When cells are experimentally treated with NF-kB activators, the activation process is initiated via a signaling cascade(s) involving several sequential components of NF-kB. Currently, the steps leading to NF-kB activation remain unknown and most of the components of this pathway have not been identified. One of strategies of killing tumor cells is to design therapeutic agents to block these signaling pathways by targeting one or more of their components. In this project, we are going to characterize some of the components mediating the activation of NF-kB. These findings may be utilized to design therapeutic agents to block activation of NF-kB, therefore improving the effectiveness of cancer-killing agents.
Additional file 1: of Nuclear Wiskottâ  Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells
Creators: name: Kuznetsov, Nikolai
name: Bader Almuzzaini
name: Kritikou, Joanna
name: Baptista, Marisa
name: Oliveira, Mariana
name: Marton Keszei
name: Snapper, Scott
name: Percipalle, Piergiorgio
name: Westerberg, Lisa
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Supplementary Figures S1â  S7. (PDF 1766 kb)
Hazardous Waste Program status report 1988
Creators: name: Trela, John J.
Publisher: name: No Publisher Supplied
Year: 1988

description: The October 1988 "Site Status Reports on Hazardous Waste Remediation" presents a detailed briefing of sites undergoing remediation through the various program areas. Remedial activities for sites under Superfund, Enforcement (major Water and Hazardous Waste Management cases) and the Environmental Cleanup Responsibility Act (ECRA) are documented in this book. The individual site status sheets provide the current status as of June 30th.
Cryptonura abmalensis Arbea, Yahyapour & Shayanmehr 2022
Creators: name: Mayvan, Mahmood Mehrafrooz
name: Greenslade, Penelope
name: Sadeghi-Namaghi, Hussein
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Poduromorpha
Neanuridae
Cryptonura
Cryptonura abmalensis

description: Cryptonura abmalensis Arbea, Yahyapour & Shayanmehr, 2022
– Cryptonura abmalensis Arbea, Yahyapour & Shayanmehr, in: Yahyapour et al. 2022: 258.
MAZ: Yahyapour et al. 2022.
Ecology and habitat in Iran: forest soil and leaf litter.
General distribution: species known only from type locality (Yahyapour et al. 2022).
description: Published as part of Mayvan, Mahmood Mehrafrooz, Greenslade, Penelope & Sadeghi-Namaghi, Hussein, 2023, An annotated checklist of the Collembola (Hexapoda) from Iran, pp. 1-101 in Zootaxa 5275 (1) on page 27, DOI: 10.11646/zootaxa.5275.1.1, http://zenodo.org/record/7898948
Grapsus albolineatus Latreille, in Milbert 1812
Creators: name: Devi, S. Suvarna
name: Mendoza, Jose C. E.
name: Ravinesh, R.
name: Idress Babu, K. K.
name: Kumar, A. Biju
name: Ng, Peter K. L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Grapsidae
Grapsus
Grapsus albolineatus

description: Grapsus albolineatus Latreille, in Milbert, 1812
Material examined. One male (69.6 x 54.5mm) (DABFUK), Kilton, 20 October 2014.
Remarks. This species was observed in all 10 islands, viz. Agatti, Kavaratti, Minicoy, Amini, Chetlat, Androth, Bitra, Kilton, Kalpeni and Kadamat. It can, however, be confused with the similar G. tenuicrustatus (Herbst, 1783), but easily separated by a number of frontal margin, cheliped and male pleonal differences: the frontal margin is smooth and entire (serrated in G. tenuicrustatus); the chelae have a purple tinge, and the inner angle of the cheliped carpus has an acutely triangular tooth (chelae dark brown, and inner angle of cheliped carpus has a broader tooth with a subtruncate base in G. tenuicrustatus); the sixth pleonal somite is shorter than the fifth (sixth pleonal somite longer than the fifth in G. tenuicrustatus) (viz. Banerjee 1960; Ng 1998).
description: Published as part of Devi, S. Suvarna, Mendoza, Jose C. E., Ravinesh, R., Idress Babu, K. K., Kumar, A. Biju & Ng, Peter K. L., 2019, On a collection of brachyuran crabs from Lakshadweep, Indian Ocean (Crustacea: Decapoda: Brachyura), pp. 477-501 in Zootaxa 4613 (3) on pages 489-490, DOI: 10.11646/zootaxa.4613.3.4, http://zenodo.org/record/3239869
MOESM1 of Longitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries
Creators: name: Drakeley, Chris
name: Abdulla, Salim
name: Selidji Agnandji
name: Fernandes, José
name: Kremsner, Peter
name: Lell, Bertrand
name: Mewono, Ludovic
name: Bache Bache
name: Mihayo, Michael
name: Juma, Omar
name: Tanner, Marcel
name: Tahita, Marc
name: Halidou Tinto
name: Salou Diallo
name: Palpouguini Lompo
name: D’Alessandro, Umberto
name: Bernhards Ogutu
name: Otieno, Lucas
name: Otieno, Solomon
name: Otieno, Walter
name: Oyieko, Janet
name: Kwaku Asante
name: Dery, Dominic
name: Adjei, George
name: Adeniji, Elisha
name: Atibilla, Dorcas
name: Owusu-Agyei, Seth
name: Greenwood, Brian
name: Gesase, Samwel
name: Lusingu, John
name: Mahende, Coline
name: Mongi, Robert
name: Method Segeja
name: Adjei, Samuel
name: Tsiri Agbenyega
name: Agyekum, Alex
name: Ansong, Daniel
name: Bawa, John
name: Boateng, Harry
name: Dandalo, Léonard
name: Escamilla, Veronica
name: Hoffman, Irving
name: Maenje, Peter
name: Martinson, Francis
name: Carter, Terrell
name: Leboulleux, Didier
name: Kaslow, David
name: Effua Usuf
name: Jean-Yves Pirçon
name: Bahmanyar, Edith
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Data for 5–19 and ≥ 20 years age categories.
A study of Bax, a gene involved in killing tumor cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cancers associated with tobacco abuse represent the single largest cause of cancer-related mortality worldwide. These smoking-associated malignancies include tumors of the lung, oral cavity, and esophagus.

 One of the major causes of cancer is mutations in genes that control cell death. Each day, an average adult produces 50-70 billion new cells in his or her body, necessitating a means for eradicating a corresponding number of cells, otherwise cells accumulate in unhealthy numbers. This cell death is accomplished by the orchestrated actions of a variety of cell survival and cell death genes which do battle with each other on a daily basis.

 Mutations caused by exposure to tobacco and smoke upset the delicate balance between the genes that lead to cell death and those that promote cell survival so that tumor cells gain a selective survival advantage and become essentially immortal, living for prolonged periods in the body and gradually accumulating without necessarily dividing any faster than normal. Moreover, once the balance between cell life and death has become upset by changes in these genes, tumors then also become resistant to killing by chemotherapy and radiation.

 This proposal seeks to understand the molecular details of how a death gene, called BAX, functions to prevent tumor formation and helps in the killing of tumor cells by radiation and chemotherapy. The information obtained from these investigations will help to establish the foundation of knowledge needed to devise novel strategies for inducing selective killing of tumor cells in patients with cancers of the lung, oral cavity and esophagus.
The flora of the Raritan formation
Creators: name: Berry, Edward W.
Publisher: name: MacCrellish & Quigley Co.
Year: 1911

description: The clays of New Jersey constitute the basis of a most importantelement in the State's mineral wealth and have long furnished the raw material for a variety of industries, and given employment to a large force Of labor, both skilled, and unskilled. The most conspicuous clay deposits in the State are those known as the Raritan, or Amboy, clays. This publication reports on the Plant Remains of the Cretaceous Clay Beds of the Raritan formation.
BAG-1, a unique gene involved in smoking-associated cancers
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The relationship between tobacco use and cancers of the lung, head & neck, oral cavity, and esophagus is irrefutable. Moreover, tumors associated with tobacco abuse represent the single largest cause of cancer-related mortality worldwide.

 Our laboratory has identified a novel gene called BAG-1. The BAG-1 protein is found at high levels in many cancers of the upper respiratory tract and has been linked to an increased risk of cancer spread (metastasis) in patients. A variety of experiments performed in our laboratory and others indicate that BAG- l is a potent regulator of tumor cell growth, which enhances cancer cell division, prolongs cell survival, and increases the ability of tumor cells to spread to other parts of the body.

 At present, little is known about how BAG-1 functions, except that it appears to interact with certain other critical proteins involved in tumor cell growth control and probably changes the shape of these proteins so that they are more potent at promoting tumor cell division and spread.

 The goal of my proposal is to delineate the molecular details of how BAG- 1 enhances tumor cell growth, survival, and metastasis. This information will provide the foundation necessary for ultimately devising novel strategies for the successful treatment of many of the cancers commonly associated with smoking and tobacco abuse.
A description of the fossil fish remains of the cretaceous, eocene, and miocene formations of New Jersey
Creators: name: Kummel, Henry B.
name: Fowler, Henry W.
Publisher: name: MacCrellish & Quigley Co.
Year: 1911

description: The present work is intended simply as a descriptive summary of the fish remains known from the late Mesozoic and Cenozoic formations within the limits of the State of New Jersey.
Plagusia squamosa
Creators: name: Devi, S. Suvarna
name: Mendoza, Jose C. E.
name: Ravinesh, R.
name: Idress Babu, K. K.
name: Kumar, A. Biju
name: Ng, Peter K. L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Plagusiidae
Plagusia
Plagusia squamosa

description: Plagusia squamosa (Herbst, 1790)
Material examined. 1 male (36.6 x 35.4 mm) (DABFUK), Kavaratti, 13 October 2014; 1 female (21.2 x 18.7 mm) (DABFUK), Kilton, 20 October 2014; 2 females (20.5 x 19.2 mm, 13.02 x 12.98 mm) (DABFUK), Androth, 2 February 2015.
Remarks. This species was also seen in the islands of Amini, Bitra, Chetlat, Kadamat, Kalpeni and Minicoy, but specimens were not collected. Schubart & Ng (2000) showed that the better known name, Plagusia tuberculata Lamarck, 1818, is a junior synonym of P. squamosa (Herbst, 1790). The species has a wide Indo-West Pacific distribution (Crosnier 1965; Schubart & Ng 2000).
description: Published as part of Devi, S. Suvarna, Mendoza, Jose C. E., Ravinesh, R., Idress Babu, K. K., Kumar, A. Biju & Ng, Peter K. L., 2019, On a collection of brachyuran crabs from Lakshadweep, Indian Ocean (Crustacea: Decapoda: Brachyura), pp. 477-501 in Zootaxa 4613 (3) on page 490, DOI: 10.11646/zootaxa.4613.3.4, http://zenodo.org/record/3239869
Structural determinants of alpha-toxin: nAChR interactions
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Information from the brain is translated into an electrical response within the central nrevous system by the action of chemical compunds (neurotransmitters) binding two sites on tissue membranes (receptors). The focus of our research is one of these receptors, namely the nicotinic acetylcholine receptor, because it binds nicotine. The receptor consists of five subunits which are arranged around a funnel-shaped channel. When two molecules of neurotransmitter bind to the subunits at the same time, the channel opens to allow the passage of charged particles (ions) which leads to message propagation. The nicotinic receptor is the best studied of several related and medically important receptors. However, our knowledge of the three-dimensional structure of this model receptor and how the receptor-drug complex causes its effects is limited.

 We address the structure-function question by analyzing the interaction of a muscle receptor with a compound which is highly specific for this receptor. The compound is a protein component of snake venom which is a neurotoxin because the protein binds irreversibly to the receptor and inactivates it. The advantage of this compound is that we know its configurations.

 The goal of our research is to provide a comprehensive view of how the toxin and the channel interact. We will do this by determining the important regions for toxin-receptor interaction by looking where the toxin and receptor bind together. Since we know the structure of the toxin, we can determine the structure of the receptor at those sites. It is important to increase our understanding of the relationship between the structure and the function for toxin or drug interactions with these types of receptors because they will provide insight into how the receptor channels are important to memory and learning events and to neurological disorders which interfere with these events.
Annual administrative report of the state geologist for the year 1911; Including a report on Shark River Inlet
Creators: name: Kummel, Henry B.
name: Vermeule, C. C.
Publisher: name: MacCrellish & Quigley Co.
Year: 1912

description: A report on the administration, work, investigations, and meetings of the Geological Survey of New Jersey for the year 1911. Also included is a report on the improvement of Shark River Inlet.
TGF-a: we need it, but too much is bad
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: We plan to study how a protein, known as transforming growth factor-alpha (TGF-alpha), contributes to the development of up to 85% of lung cancers (a disease mainly caused by smoking of cigarettes). TGF-alpha is present in both normal and cancer cells and can stimulate cell growth. However, there is a difference in the amount of TGF-alpha produced in normal and cancer cells. The human body is a terrific machine in which every part is built according to what it is used for. Therefore, only a limited level of growth is needed for most cells in the body. Thus, normal cells are allowed to produce only a small amount of TGF-alpha. When cells in the body have lost their ability to control their growth, they may form cancers. Many cancer cells, including most lung cancer cells, produce much more TGF-alpha than normal cells.

 Not only do normal and cancer cells produce different amounts of TGF-alpha, they also use it differently. In normal tissues, TGF-alpha is retained by the producer cells, therefore it only stimulates the producer cells themselves or the neighboring cells right next to the producer. However, cancer cells release TGF-alpha into the environment made of tissue fluid. As a result, the freely diffusible TGF-alpha can stimulate the growth of cells at great distance from the producer cells. The overproduction of TGF-alpha by cancer cells helps cancers grow and spread from their original site to other organs. These disseminated cancer cells form secondary tumors which eventually cause malfunction of multiple and important organs at late stage of disease and is the major cause of death of cancer patients.

 Release of TGF-alpha apparently is a strategy that cancer cells use to gain growth advantages over normal cells. However, medical researchers know very little about how cancer cells can release TGF-alpha. In this proposed study, we will attempt to address this important question. We hope that our work can identify which protein is responsible for release of the TGF-alpha from producer cells into the environment, and can provide information with respect to what kind of event can control this release. Therefore, our work is important and significant not only because it will help us understand how cancers, including those of the lung, occur and progress, but may also help develop new treatments for cancer patients.
Percnon guinotae Crosnier 1965
Creators: name: Devi, S. Suvarna
name: Mendoza, Jose C. E.
name: Ravinesh, R.
name: Idress Babu, K. K.
name: Kumar, A. Biju
name: Ng, Peter K. L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Percnidae
Percnon
Percnon guinotae

description: Percnon guinotae Crosnier, 1965
Material examined. 2 males (8.6 x 7.0 mm, 14.1 x 12.8 mm) (DABFUK), Minicoy, 16 August 2013; 1 female (10.9 x 10.8 mm) (DABFUK), Kalpeni, 20 October 2015.
Remarks. Kumaralingam et al. (2017) first recorded this species from Lakshadweep, which has a wide range in the Indian Ocean (Crosnier 1965).
description: Published as part of Devi, S. Suvarna, Mendoza, Jose C. E., Ravinesh, R., Idress Babu, K. K., Kumar, A. Biju & Ng, Peter K. L., 2019, On a collection of brachyuran crabs from Lakshadweep, Indian Ocean (Crustacea: Decapoda: Brachyura), pp. 477-501 in Zootaxa 4613 (3) on page 490, DOI: 10.11646/zootaxa.4613.3.4, http://zenodo.org/record/3239869
Percnon planissimum
Creators: name: Devi, S. Suvarna
name: Mendoza, Jose C. E.
name: Ravinesh, R.
name: Idress Babu, K. K.
name: Kumar, A. Biju
name: Ng, Peter K. L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Percnidae
Percnon
Percnon planissimum

description: Percnon planissimum (Herbst, 1804)
Material examined. 1 female (12.9 x 12.6 mm) (DABFUK), Kalpeni, 4 October 2014.
Remarks. Previously recorded from Lakshadweep (Alcock 1900b; Thomas 1969; Dev Roy 2008; Kumaralingam et al. 2017). This is a widespread species in the Indo-West Pacific (Crosnier 1965). Specimens were also observed on Kavaratti and Minicoy but not collected.
description: Published as part of Devi, S. Suvarna, Mendoza, Jose C. E., Ravinesh, R., Idress Babu, K. K., Kumar, A. Biju & Ng, Peter K. L., 2019, On a collection of brachyuran crabs from Lakshadweep, Indian Ocean (Crustacea: Decapoda: Brachyura), pp. 477-501 in Zootaxa 4613 (3) on page 490, DOI: 10.11646/zootaxa.4613.3.4, http://zenodo.org/record/3239869
Functional significance of the protein CD40 in lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer is the most common cause of death from cancer in the United States in both men and women. The single most important risk factor for this deadly disease is cigarette smoking. During the next decade, more than 1.5 million people will be diagnosed with lung cancer, the majority of whom will have advanced disease which cannot be treated by surgery. Current medical therapies for lung cancer, including chemotherapy and radiation therapy, do not greatly improve survival. New approaches to treating lung cancer are desperately needed. Research studying the body's own immune response to cancer cells may allow for the development of new treatments which enable the cells of the immune system to more effectively recognize and kill cancer cells.

 The research described in this proposal serves to evaluate possible methods by which human lung cancer cells avoid attack by the immune system. Lung cancer cells may inactivate cells from the body’s immune system by using a protein called CD40. The CD40 molecule was first found on cells of the immune system (B cells) where it acts to coordinate a cascade of events to protect the body from invasion by bacteria, viruses, and other harmful substances. The function of CD40 in lung cancer is not known. Our recent research suggests that the presence of this molecule on these tumors may allow the cancer cell to avoid attack by cells of the immune system. This may be a means by which cancer cells hide from the immune system. If we alter the function of the CD40 molecule on these cancer cells, it appears that the tumor cells change in a way that may allow cells of the immune system to attack and kill these cancers. The studies outlined in this research proposal will evaluate these findings in greater detail to better understand why the cells of the immune system are not very effective in killing cancer cells. Through this evaluation, insight may be developed to help discover new ways to treat patients with lung cancer using the body's own immune system.
Cryptonura dohezarensis Arbea, Yahyapour & Shayanmehr 2022
Creators: name: Mayvan, Mahmood Mehrafrooz
name: Greenslade, Penelope
name: Sadeghi-Namaghi, Hussein
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Poduromorpha
Neanuridae
Cryptonura
Cryptonura dohezarensis

description: Cryptonura dohezarensis Arbea, Yahyapour & Shayanmehr, 2022
– Cryptonura dohezarensis Arbea, Yahyapour & Shayanmehr, in: Yahyapour et al. 2022: 254.
MAZ: Yahyapour et al. 2022.
Ecology and habitat in Iran: forest soil and leaf litter.
General distribution: species known only from type locality (Yahyapour et al. 2022).
description: Published as part of Mayvan, Mahmood Mehrafrooz, Greenslade, Penelope & Sadeghi-Namaghi, Hussein, 2023, An annotated checklist of the Collembola (Hexapoda) from Iran, pp. 1-101 in Zootaxa 5275 (1) on page 27, DOI: 10.11646/zootaxa.5275.1.1, http://zenodo.org/record/7898948
Boosting the immune response against lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Epidemiological studies show a strong correlation between tobacco smoking and lung cancer. It has been documented that the overwhelming majority of lung cancers, greater than 90 % are caused by cigarette smoking. Lung cancer is the leading cause of cancer deaths in the United States and more than 150,000 Americans died from lung cancer in 1997. There are currently fifty million smokers in the U.S. and another fifty million ex-smokers. This means that approximately one third of the U.S. population is at high risk for this terrible disease. With the existing therapeutic efforts, patients with lung cancer have a poor prognosis. Less than 15 % of lung cancer patients live 5 years. Failure of conventional treatments has led to an intensive search for alternative forms of treatment. Successful treatment that relies on the bodies immune system might be achieved through a better understanding of how lung cancer cells escape detection by the immune system (immunosuppression). In our preliminary studies we have found that the immune suppressive action in lung cancer is due to the over-expression of the enzyme cyclooxygenase-2. Cyclooxygenase-2 activity is significantly increased in cancerous tissues compared to their normal counterparts in several different cancer types and our studies are the first to also document this over-expression in human lung cancer. Our preliminary studies indicate that cyclooxygenase-2 expression in lung cancer leads to a decrease in anti tumor immunity. Although the break down products of cyclooxygenase -2 have been identified as suppressing immunity, it is not well understood how this occurs. A basic understanding of the mechanism involved in the immunosuppression caused by the lung tumor will enable us to devise better treatment strategies to control lung cancer.
Additional file 2: Figures S1â  S6. of Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses
Creators: name: Costello, Joseph
name: Kershaw, Christopher
name: Castelli, Lydia
name: Talavera, David
name: Rowe, William
name: Sims, Paul
name: Ashe, Mark
name: Grant, Christopher
name: Hubbard, Simon
name: Pavitt, Graham
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Figures. Figures and legends for Supplementary Figures S1â  S6. (PDF 7144Â kb)
A preliminary report on the archaeology survey of the state of New Jersey
Creators: name: Skinner, Alanson
name: Schrabisch, Max
Publisher: name: MacCrellish & Quigley Co.
Year: 1913

description: This report is an archaeological survey of New Jersey and includes a list of sites with their characters noted in respect to superficial surface indications. The report concludes that practically all such surface remains belong to the historic Indians and his immediate ancestors, and there are no new positive traces of pre-Indian culture.
The role of nitric oxide in nicot induced muscle cell death
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Many pathological conditions are associated with muscle weakness or atrophy. Nicotine, a predominant component of tobacco, is known to activate receptors on muscle cells ('nicotinic receptors') resulting in cell stimulation. Excessive stimulation of these receptors, however results in muscle deterioration. The over activation of muscle cells has been related to the wasting and weakness of neck and shoulder muscles. Similarly, muscle cells directly exposed to nicotine die within a relatively short time period.

 The long term goal of the present grant proposal is to identify the pathways leading from nicotine exposure to muscle degeneration. Specifically, nitric oxide is known to be responsible for many biological functions ranging from regulating blood vessel relaxation thereby affecting blood pressure to inducing cell death in the brain in models of stroke. Recent evidence suggests that this gas may play a role in mediating muscle cell death from nicotine exposure as well. The proposed experiments will provide insight into such a role for nitric oxide by characterizing the effect of 'nicotinic receptor' stimulation on nitric oxide production and relating this to muscle cell death. In addition, we will conduct experiments on rats exposed to compounds, which are used in the treatment of Alzheimer's disease. These compounds also result in the over activation of these receptors and potentially cause muscle cell death. We will determine whether nitric oxide acts as an intermediate to induce cell death in this model as well. We will also investigate whether agents which block nitric oxide production can prevent muscle degeneration. Understanding these mechanisms, therefore, may provide a means for treating such muscle disorders.
How are beneficial cholesterol transport proteins produced?
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoking is one of the major risk factors for coronary and peripheral vascular disease. Users of tobacco have a 2.5 fold higher prevalence of elevated blood cholesterol (hypercholesterolemia) than non-smokers, which further increases their risk for cardiovascular disease. As a dietary fat that is also made by the body, cholesterol is not soluble in the blood and must be carried in the blood stream via several fat-transporting proteins. One of these proteins is apolipoprotein B (apo-B), which is found in two different sizes in human blood: the large apo-B100 and the smaller apo-B48. Several studies that focused on reducing blood cholesterol levels demonstrated that it beneficially corresponds with having relatively lower amounts of apo-B100 in blood. The larger apo-B100 is produced by the liver while the smaller apo-B48 is formed in the intestines from a mutated (i.e., edited) form of the same genetically-coded signal molecule (messenger RNA or mRNA) that is used to produce the larger apo-B100. This specialized mutating or "editing" process is carried out by several enzymes called an "editing complex". Whenever the apo-B mRNA comes into contact with this editing complex, the apo-B mRNA is transformed, resulting in the production of apo-B48 in the blood. This particular mRNA editing mechanism is therefore considered to be beneficial for human health, with potential therapeutic value for lowering blood cholesterol levels. Our understanding of the editing process could result in the development of drugs that either mimic its activity or induce natural apo-B mRNA editing in the human liver. The goal of this research is to define the component proteins that form the editing complex and to understand how they conduct and control successful apo-B mRNA editing.
MOESM1 of Profile of stroke patients treated at a rehabilitation centre in Bangladesh
Creators: name: Mamin, Firoz
name: Islam, Muhammad
name: Farjana Rumana
name: Faruqui, Farhana
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Level of education and awareness of the presence of stroke risk factors.
Percnon Gistel 1848
Creators: name: Devi, S. Suvarna
name: Mendoza, Jose C. E.
name: Ravinesh, R.
name: Idress Babu, K. K.
name: Kumar, A. Biju
name: Ng, Peter K. L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Percnidae
Percnon

description: Percnon sp.
(Fig. 2H)
Material examined. 1 megalopa (6.9 x 5.1 mm) (DABFUK), Kavaratti, 11 October 2014.
Remarks. The distinctive characters identifying the megalopa as a species of Percnon are the carapace outline, the three long rostral spines on the anterior of the carapace, and the short spines on the ventral (flexor) margin of the ambulatory dactyli. It resembles the megalopa of the Atlantic species, Percnon gibbesi (H. Milne Edwards, 1853) (cf. Paula & Hartnoll 1989: 31, fig. 11), but the carapace of the present specimen is much narrower and the legs are relatively longer. It is difficult to ascertain which of the two preceding, sympatric species of Percnon it belongs to, as megalopal differences between the species have not been documented.
description: Published as part of Devi, S. Suvarna, Mendoza, Jose C. E., Ravinesh, R., Idress Babu, K. K., Kumar, A. Biju & Ng, Peter K. L., 2019, On a collection of brachyuran crabs from Lakshadweep, Indian Ocean (Crustacea: Decapoda: Brachyura), pp. 477-501 in Zootaxa 4613 (3) on page 490, DOI: 10.11646/zootaxa.4613.3.4, http://zenodo.org/record/3239869
Cryptonura maxima Smolis, Falahati & Skarzynski 2012
Creators: name: Mayvan, Mahmood Mehrafrooz
name: Greenslade, Penelope
name: Sadeghi-Namaghi, Hussein
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Poduromorpha
Neanuridae
Cryptonura
Cryptonura maxima

description: Cryptonura maxima Smolis, Falahati & Skarżyński, 2012
– Cryptonura maxima Smolis et al. 2012: 55.
GO: Smolis et al. 2012; MAZ: Smolis & Skarżyński 2020.
Ecology and habitat in Iran: forest soil and leaf litter.
General distribution: species probably endemic to Iran (Smolis et al. 2012).
description: Published as part of Mayvan, Mahmood Mehrafrooz, Greenslade, Penelope & Sadeghi-Namaghi, Hussein, 2023, An annotated checklist of the Collembola (Hexapoda) from Iran, pp. 1-101 in Zootaxa 5275 (1) on page 27, DOI: 10.11646/zootaxa.5275.1.1, http://zenodo.org/record/7898948
The mineral industry of New Jersey for 1912
Creators: name: Twitchell, M. W.
Publisher: name: MacCrellish & Quigley Co.
Year: 1912

description: As in 1910 and 1911, the statistics of the mineral production of New Jersey for the calendar year 1912 were collected by the Geological Survey of New Jersey in co-operation with the United States Geological Survey. This method avoids the necessity of troubling producers by requests from two organizations, and insures greater accuracy and completeness in the results. The total value of the mineral production in New Jersey in 1912 was $40,391,548. This is $2,6&5,13& more than. in 1911.
MOESM1 of Longitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries
Creators: name: Drakeley, Chris
name: Abdulla, Salim
name: Selidji Agnandji
name: Fernandes, José
name: Kremsner, Peter
name: Lell, Bertrand
name: Mewono, Ludovic
name: Bache Bache
name: Mihayo, Michael
name: Juma, Omar
name: Tanner, Marcel
name: Tahita, Marc
name: Halidou Tinto
name: Salou Diallo
name: Palpouguini Lompo
name: D’Alessandro, Umberto
name: Bernhards Ogutu
name: Otieno, Lucas
name: Otieno, Solomon
name: Otieno, Walter
name: Oyieko, Janet
name: Kwaku Asante
name: Dery, Dominic
name: Adjei, George
name: Adeniji, Elisha
name: Atibilla, Dorcas
name: Owusu-Agyei, Seth
name: Greenwood, Brian
name: Gesase, Samwel
name: Lusingu, John
name: Mahende, Coline
name: Mongi, Robert
name: Method Segeja
name: Adjei, Samuel
name: Tsiri Agbenyega
name: Agyekum, Alex
name: Ansong, Daniel
name: Bawa, John
name: Boateng, Harry
name: Dandalo, Léonard
name: Escamilla, Veronica
name: Hoffman, Irving
name: Maenje, Peter
name: Martinson, Francis
name: Carter, Terrell
name: Leboulleux, Didier
name: Kaslow, David
name: Effua Usuf
name: Jean-Yves Pirçon
name: Bahmanyar, Edith
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Data for 5–19 and ≥ 20 years age categories.
Final Technical Report
Creators: name: Boodhoo, Kamelia
name: Russo Abegão, Fernando
Publisher: name: Zenodo
Year: 2024

description: The overall aim of BioSPRINT is to develop, test and validate process intensification (PI) methods (up to TRL 4-5) for sustainable and cost-effective purification and conversion of sugars from the hemicellulose (HMC) fraction of lignocellulosic biomass to obtain biorenewable furan-based resins for novel polymeric applications. Deliverable D8.3 reports the technical progress achieved between M26 and M48 of this 4-year project.