cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Amblyoproctus chalumeaui Endrodi 1977
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Amblyoproctus
Amblyoproctus chalumeaui

description: Amblyoproctus chalumeaui Endrödi, 1977
Amblyoproctus chalumeaui Endrödi 1977c: 40 (Brazil (NA))
Distribution. Suriname: MHCN - NEW COUNTRY RECORD (Suriname, Sipaliwini.). French Guiana: Duranton 2011: 23; Ponchel 2011: 61; Brûlé and Dalens 2012a annex 4: 18; Dupuis 2016b: 110. Brazil (NA): Endrödi 1977c: 40 (NA), 1985a: 707; Lachaume 1992: 52. Other: Endrödi 1977c: 40 (Colombia, Ecuador, Peru), 1985a: 707 (Ecuador, Peru); Lachaume 1992: 52 (Ecuador, Peru).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 215, DOI: 10.5281/zenodo.3678492
Challenges and novel reconstruction techniques for the CMS High Granularity Calorimeter for HL-LHC
Creators: name: Shamik Ghosh
Publisher: name: Zenodo
Year: 2022

description: he Compact Muon Solenoid (CMS) detector at the CERN Large Hadron Collider (LHC) is undergoing an extensive Phase II upgrade program to prepare for the challenging conditions of the High-Luminosity LHC (HL-LHC). To sustain the harsh conditions foreseen in Phase II the CMS experiment has designed a novel endcap calorimeter that uses approx. 5.8M radiation-tolerant Silicon sensors. These sensors will sample the electromagnetic and hadronic particle showers using 47 layers with fine lateral granularity and providing 5D measurements of energy, position and timing. In regions of sufficiently low radiation, small scintillator tiles with individual SiPM readout are employed. Developing a reconstruction sequence that fully exploits the granularity to achieve optimal electromagnetic and hadron identification, as well as a good energy resolution, in the presence of pileup, is a challenging task. A modular iterative clustering framework (TICL) is being developed to cope with this task. The framework starts from input clusters of energy deposited in individual calorimeter layers delivered by an "imaging", density-based, algorithm In view of the expected pressure on the computing capacity in the HL-LHC era, the algorithms and their data structures are being designed with GPUs in mind. In addition, machine learning techniques are being investigated and integrated into the reconstruction framework. This talk will describe the approaches being considered and discuss the first results.
Additional file 1 of Alpha lipoic acid antagonizes cytotoxicity of cobalt nanoparticles by inhibiting ferroptosis-like cell death
Creators: name: Yake Liu
name: Wenfeng Zhu
name: Dalong Ni
name: Zihua Zhou
name: Gu, Jin-Hua
name: Weinan Zhang
name: Huanjian Sun
name: Liu, Fan
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Figure S1. Distribution of CoNPs in the well. CoNPs were treated as described above methods, and then quickly added to each well. Microscopic observations showed that the CoNPs were evenly distributed at the bottom of the wells and were sand-like particles, which proved that the amount of CoNPs in each well was accurate. a) the distribution of CoNPs in blank well(20X); b) CoNPs are evenly distributed in the cell without agglomerating into larger clusters(20X). Figure S2. TEM image of CoNPs in the cells. Cobalt nanoparticles are distributed in clusters in cells, and the diameter of the cobalt nanoparticles is less than 5 0nM, which is round or elliptical. Figure S3. Calcein AM/PI staining image (×20).The results showed that 400 μM CoNPs caused significant changes in cell viability, smaller cell size, and more dead cells (red) than live cells (green). ALA significantly reduces cell mortality and maintains cell morphology and vitality. Figure S4. CoNPs accumulate in clusters in cells. CoNPs are encapsulated into multiple vesicles in the cell and can be discharged out of the cell through the vesicles, indicating that vesicular transport may participate in the intracellular transport of cobalt nanometers. Table S1. The effects of ALA and CoNPs on intracellular GSH and GSSG.
Amblyoproctus cornutus Dechambre 2008
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Amblyoproctus
Amblyoproctus cornutus

description: Amblyoproctus cornutus Dechambre, 2008
Amblyoproctus cornutus Dechambre 2008a: 3 (French Guiana)
Distribution. French Guiana: Dechambre 2008a: 3; Ponchel 2011: 61; Dupuis 2016b: 110.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 216, DOI: 10.5281/zenodo.3678492
Book Review: "הגדולים – אישים שעיצבו את פני היהדות החרדית בישראל"
Creators: name: Neriya-Ben Shahar, R.
Publisher: name: Zenodo
Year: 2018

description: Book Review: "הגדולים – אישים שעיצבו את פני היהדות החרדית בישראל"
Identification of alcohol problems among health maintenance organization patients, using the MacAndrew Alcoholism Scale.
Creators: name: Frances, Mary Brown
Publisher: name: University of Utah
Year: 2012
Subjects: Diagnosis
Psychotherapy

description: Exploratory research was conducted with 178 men and 321 women (aged 18-69), patients of FHP Utah, to test the relationship between alcoholism as measured by the MacAndrew Alcoholism Scale (MAC) and various life-problems. Problem areas included physical, emotional, job/legal/economic, and family/social. Patients were also questioned about their drinking practices. Cut-off scores on the MAC of 24 for males and 27 for females operationally defined patients as having an alcohol problem.  The following hypotheses were tested: (1) sex differences would be shown in the number of individuals diagnosed; (2) individuals diagnosed as alcoholic would exhibit a greater number of life problems than nonalcoholics; (3) problems exhibited would not be confined to the physical area, but would include two or more problem areas; and (4) no sex differences would be shown between the life problems shown by alcoholic males vs females. The MAC identified 31.5% of the males and 7.2% of the females as alcoholic. This was a significant difference (p < .001) and supported Hypothesis 1. Possible reasons for the abnormally high number of male alcoholics are discussed, as well as a number of ways of determining the true meaning of this finding. Individuals diagnosed as alcoholic exhibited many more problems identified by the patient (7.0 vs 3.9 for males, and 9.2 vs 5.8 for females, for alcoholics vs nonalcoholics). These results were significant (p < .001). Problems identified by the physician for alcoholics vs nonalcoholics was .45 vs .22 for males (p < .05) and .48 vs .17 for females (p < .08). In sum the results supported Hypothesis 2. Hypothesis 3, that problems shown would reflect two or more problem areas was supported. Life-problems from all four areas were significantly associated with a diagnosis of alcoholism. Proportionately fewer physical problems were seen despite the test instrument being saturated with physical problems diagnostic of alcohol problems in early to middle stages of problem alcohol use. Significant sex differences were found among the signs and symptoms diagnostic of alcohol problems. Thus Hypothesis 4 was not supported. The literature in the alcoholism field has not so far addressed this issue. Cautions on the interpretation of the data are discussed as well as implications for future research.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.11.1971, erstellt von Alexandra Dimitriu-Parepeanu, Observatorium Bukarest
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1971

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Astronomischen Observatorium Bukarest, Solarsektor, Rumänien. Später wurden ergänzende Angaben aufgrund weiterer Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Instrument: Zeiss-Refraktor (Öffnung 130mm, f = 1950mm, projiziertes Sonnenbild D = 25cm)
Adaptation of cancellous bone to habitual loading: trabecular architecture of the artiodactyl calcaneus
Creators: name: Kopp, Derinna Vivian
Publisher: name: University of Utah
Year: 2014
Subjects: Bone adaptation
Cancellous bone
Trabecular architecture

description: The functional adaptation model suggests that differences in biomechanical forces resulting from habitual loading will be reflected in the trabecular architecture of cancellous bone. Increasingly, trabecular architecture is used to compare habitual loading history in both extant and extinct animals. Yet, most research is limited to comparisons of differences in architectural measures between species, as it is not currently known exactly how trabecular architecture differs with varying principal loading conditions. This study analyzed the cancellous bone of the artiodactyl calcaneus (sheep and deer) to examine if and how trabecular architecture varies with respect to habitual loading in compression and tension. The artiodactyl calcaneus has been shown to be habitually loaded in bending with compression predominant in the dorsal aspect of the bone and tension predominant in the plantar aspect of the bone. Architectural measures analyzed included bone volume fraction, trabecular thickness, trabecular separation, trabecular number, connectivity density, and degree of anisotropy. Trabecular architecture was assessed across the length of the bone, between the dorsal and plantar aspects of the bone, with variation of cortical bone thickness and geometry, and between the two species to assess how cancellous bone may specifically adapt to habitual compression and tension. Across the length of the calcaneus the cancellous bone was shown to become less dense and less connected with greater trabecular separation iv and fewer trabeculae for both the sheep and deer. The data from the dorsal and plantar regions of both species indicate that alteration in trabecular architecture occurs at a localized level rather than across each region as a whole. Cortical thickness and geometry were shown to have a significant effect on trabecular architecture in both species. Significant differences were found between the sheep and the deer cancellous bone specifically in the planter region and in concordance with predicted loading magnitudes for each species. While some significant differences in trabecular architectural were identified, much of the variation in the trabecular architecture across the length of the bone and between the dorsal and planar regions was not significant suggesting that loading regime alone may not be sufficient to explain trabecular architectural variation.
Additional file 1 of Generation of cortical neurons through large-scale expanding neuroepithelial stem cell from human pluripotent stem cells
Creators: name: Shumei Zhao
name: Duan, Kui
name: Zongyong Ai
name: Baohua Niu
name: Yanying Chen
name: Ruize Kong
name: Tianqing Li
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Developmental Biology

description: Additional file 1.
Amblyoproctus dechambrei Ponchel 2009
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Amblyoproctus
Amblyoproctus dechambrei

description: Amblyoproctus dechambrei Ponchel, 2009
Amblyoproctus dechambrei Ponchel 2009b: 301 (French Guiana)
Distribution. French Guiana: Ponchel 2009b: 301, 2011: 61; Dupuis 2016b: 110.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 216, DOI: 10.5281/zenodo.3678492
Sonnenfleckenzeichnung Nr. 23710.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 17.07.1971, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1971

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Book Review: Yohai Hakak. Haredi Masculinities Between The Yeshiva, The Army, Work And Politics: The Sage, The Warrior And The Entrepreneur.
Creators: name: Neriya-Ben Shahar, R.
Publisher: name: Zenodo
Year: 2018

description: Book Review: Yohai Hakak. Haredi Masculinities between the Yeshiva, the Army, Work and Politics: The Sage, the Warrior and the Entrepreneur.
Sonnenfleckenzeichnung Nr. 23737.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 14.08.1971, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1971

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Vitamin D3-VDR-PTPN6 axis mediated autophagy contributes to the inhibition of macrophage foam cell formation
Creators: name: Kumar, Sumit
name: Nanduri, Ravikanth
name: Bhagyaraj, Ella
name: Kalra, Rashi
name: Ahuja, Nancy
name: Chacko, Anuja P.
name: Tiwari, Drishti
name: Sethi, Kanupriya
name: Saini, Ankita
name: Chandra, Vemika
name: Jain, Monika
name: Gupta, Shalini
name: Bhatt, Deepak
name: Gupta, Pawan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Macrophage derived foam cells in atherosclerotic plaques are the major factor responsible for the pathogenesis of atherosclerosis (AS). During advanced AS, macrophage-specific macroautophagy/autophagy is dysfunctional. 1, 25-dihydroxy vitamin D3 (VitD3) and its receptor VDR (vitamin D receptor) are reported to inhibit foam cell formation and induce autophagy; however, the role of VitD3-VDR-induced autophagy and foam cell formation in AS has not been explored. Here we find that VitD3 significantly recovered oxidized low-density lipoprotein-impaired autophagy, as well as increased autophagy-mediated lipid breakdown in mouse bone marrow-derived macrophages and human monocyte-derived macrophages, thus inhibiting the conversion of macrophages into foam cells. Importantly, VitD3 functions through its receptor VDR to upregulate autophagy and attenuate the accumulation of lipids in macrophages. Moreover, this study is the first occasion to report the interesting link between VitD3 signaling and PTPN6/SHP-1 (protein tyrosine phosphatase non-receptor type 6) in macrophages. VitD3-induced autophagy was abrogated in the presence of the PTPN6/Ptpn6 shRNA or inhibitor. VDR along with RXRA (retinoid X receptor alpha), and NCOA1 (nuclear receptor coactivator 1), are recruited to a specific response element located on the gene promoter and induce PTPN6 expression. PTPN6 contributes to VitD3-mediated autophagy by regulating autophagy-related genes via activation of MAPK1 (mitogen-activated protein kinase 1) and CEBPB (CCAAT enhancer binding protein beta). Furthermore, expression of PTPN6 is also crucial for VitD3-mediated inhibition of macrophage foam cell formation through autophagy. Thus, VitD3-VDR-PTPN6 axis-regulated autophagy attenuates foam cell formation in macrophages.
Temporal Reasoning in Medicine Using Dynamic Bayesian Networks
Creators: name: Nachimuthu, Senthil Kumar
Publisher: name: University of Utah
Year: 2014

description: Temporal reasoning denotes the modeling of causal relationships between different variables across different instances of time, and the prediction of future events or the explanation of past events. Temporal reasoning helps in modeling and understanding interactions between human pathophysiological processes, and in predicting future outcomes such as response to treatment or complications. Dynamic Bayesian Networks (DBN) support modeling changes in patients' condition over time due to both diseases and treatments, using probabilistic relationships between different clinical variables, both within and across different points in time. We describe temporal reasoning and representation in general and DBN in particular, with special attention to DBN parameter learning and inference. We also describe temporal data preparation (aggregation, consolidation, and abstraction) techniques that are applicable to medical data that were used in our research. We describe and evaluate various data discretization methods that are applicable to medical data. Projeny, an opensource probabilistic temporal reasoning toolkit developed as part of this research, is also described. We apply these methods, techniques, and algorithms to two disease processes modeled as Dynamic Bayesian Networks. The first test case is hyperglycemia due to severe illness in patients treated in the Intensive Care Unit (ICU). We model the patients' serum glucose and insulin drip rates using Dynamic Bayesian Networks, and recommend insulin drip rates to maintain the patients' serum glucose within a normal range. The model's safety and efficacy are proven by comparing it to the current gold standard. The second test case is the early prediction of sepsis in the emergency department. Sepsis is an acute life threatening condition that requires timely diagnosis and treatment. We present various DBN models and data preparation techniques that detect sepsis with very high accuracy within two hours after the patients' admission to the emergency department. We also discuss factors affecting the computational tractability of the models and appropriate optimization techniques. In this dissertation, we present a guide to temporal reasoning, evaluation of various data preparation, discretization, learning and inference methods, proofs using two test cases using real clinical data, an open-source toolkit, and recommend methods and techniques for temporal reasoning in medicine.
Roles of Delayed Repolarization and Altered Calcium Handling in Determining Regional Arrhythmia Propensity Under Conditions of Reduced Inward-Rectifier Potassium Current
Creators: name: Radwański, Przemysław
Publisher: name: University of Utah
Year: 2014

description: Andersen-Tawil syndrome Type 1 (ATS1) is a disorder linked to a loss of function of the inward rectifier current IK1. Such a reduction in repolarization reserve has an established link with heterogeneous action potential duration (APD) prolongation. This in turn can serve as a substrate for reentrant arrhythmias. While APD prolongation and increased dispersion have been reported in pharmacological models of ATS1 they have not been linked with arrhythmogenesis. APD prolongation secondary to reduced IK1 can increase Ca2+ entry into myocytes. The resultant accumulation of cytosolic Ca2+ has been linked with ventricular ectopies which can trigger arrhythmias. Indeed this mechanism of arrhythmogeneis has been proposed in ATS1 based on previous in silico and ex vivo studies. However, ATS1- associated cytosolic Ca2+ overload and increased arrhythmia propensity has not been demonstrated in tissue preparations. The overall goal of this research was to characterize the factors that underlie arrhythmia propensity in a pharmacological model of ATS1. To this end we performed two studies. The first study analyzed APD gradients to determine whether they were sufficient for induction of reentrant arrhythmias. The results indicated they were not. However, this study revealed increased arrhythmia propensity which correlated with cytosolic Ca2+ overload. Therefore, the second study focused on Ca2+ handling and showed that ectopic activity originated from regions of higher Na+/Ca2+ exchanger iv (NCX) functional expression relative to sarcoplasmic reticulum Ca2+ ATPase (SERCA2a), which we term "NCX dominant" regions of the heart. In support of the idea that NCX is an important determinant of ectopy, we were able to modulate both the timing as well as the frequency of ectopy by pharmacologically modulating NCX dominance. The data presented in this dissertation provide an insight into the factors by which Ca2+ handling contributes to ectopy under conditions of partial loss of IK1 function. This concept may aid in the identification of novel targets for antiarrhythmic therapy when IK1 is reduced in ATS1, as well as more prevalent disorders such as heart failure.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.11.1971, erstellt  als weitere, zusätzlich ausgeführte Tagesaufnahme von Fritz Riesen bzw. vermutlich dank auswärtiger Beobachtungen eröffnet
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1971

description: Bleistiftzeichnung vermutlich unter Einbezug der Auswertung auswärtiger Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen direkt auf dem Vordruck, unter Umständen teilweise mit dem Zeiss Coudé-Refraktor (150/2250 mm) der Eidgenössischen Sternwarte Zürich
Sonnenfleckenzeichnung Nr. 23726.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.08.1971, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1971

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung Nr. 23669.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.06.1971, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1971

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Additional file 1 of A multi-center, randomized controlled trial by the Integrative Management in Japan for Epidemic Disease (IMJEDI study-RCT) on the use of Kampo medicine, kakkonto with shosaikotokakikyosekko, in mild-to-moderate COVID-19 patients for symptomatic relief and prevention of severe stage: a structured summary of a study protocol for a randomized controlled trial
Creators: name: Takayama, Shin
name: Namiki, Takao
name: Ito, Takashi
name: Arita, Ryutaro
name: Nakae, Hajime
name: Kobayashi, Seiichi
name: Yoshino, Tetsuhiro
name: Ishigami, Tomoaki
name: Tanaka, Koichiro
name: Mosaburo Kainuma
name: Nochioka, Kotaro
name: Takagi, Airi
name: Mimura, Masaru
name: Takuhiro Yamaguchi
name: Ishii, Tadashi
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
Sonnenfleckenzeichnung Nr. 23829.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 26.11.1971, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1971

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Origins and Regulation of Progenitor Cells in the Embyronic and Adult Pancreas
Creators: name: Kopinke, Daniel
Publisher: name: University of Utah
Year: 2014

description: Type I diabetes is caused by selective loss of insulin-producing β-cells. Identifying and activating an endogenous source of new β-cells could be used to replenish those lost in this disease. The nature and existence of an adult pancreatic stem/progenitor cell population, however, is still controversial. Circumstantial evidence indicates that islet cells arise from embryonic ductal cells. In contrast, the majority of adult islet cells appear to regenerate via self-renewal during postnatal expansion and adult homeostasis. That ducts could also give rise to new beta-cells in the adult (neogenesis) was recently suggested in the context of pancreatic ductal ligation (PDL) injury. The Notch signaling pathway inhibits islet development and promotes progenitor cell maintenance during early pancreatic organogenesis, acting primarily through its target gene Hes1. While Hes1 is broadly expressed in the embryonic pancreas, only rare Hes1-expressing cells can be found in the adult organ, among mature ducts and centroacinar cells (CACs), the latter of which have been proposed to represent adult progenitors. This thesis aims to test directly the ability of duct cells to generate islet cells, and to determine the biological function of Hes1+ duct cells. For this, we performed lineage tracing and genetic manipulation using two novel Cre-lines, Muc1IC2, which marks exocrine cells, and Hes1C2, which marks Hes1+ cells. Our work has uncovered three major phases in the development of pancreatic islet cells: (i) initially, new islet cells originate from Notchresponsive exocrine cells, (ii) later in embryogenesis, Notch signaling needs to be downiv regulated in exocrine cells for islet neogenesis to proceed and (iii) from birth onwards, islet cells are maintained by replication of pre-existing cells with no detectable influx from neogenesis. Additionally, our findings demonstrated that early Hes1+ cells represent multipotent progenitors and that their immature state is maintained through active Notch signaling. Interestingly, later in development Notch promotes duct specification of Hes1-expressing bipotent exocrine progenitors. In the mature pancreas, Hes1 expression persists in Notch-sensitive centroacinar cells, which act as facultative exocrine-specific progenitor cells. Thus, the research described in this thesis determines the identity of embryonic and adult pancreatic progenitor cells, and demonstrates that these cells utilize Notch signaling for maintenance of their undifferentiated state.
Sonnenfleckenzeichnung Nr. 23811.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.10.1971, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1971

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Respiratory Tract Illness Surveillance in Patients at a Community Clinic During the 2010 Influenza Season
Creators: name: Atkinson, Annette
Publisher: name: University of Utah
Year: 2014

description: Viruses cause the majority of respiratory infections. A rapid laboratory method to accurately diagnose etiology of respiratory illness can inform physicians and guide treatment decisions. The objective of this cross-sectional, laboratory based surveillance study is to assess the sensitivity and specificity of influenza virus rapid antigen assay Quidel A+B (Quidel, San Diego, CA) and two multiplex respiratory pathogen assays [Idaho Technology FilmArray® Respiratory Panel (Idaho Technology, Inc., Salt Lake City, UT) and Qiagen ResPlex™ II (Qiagen, Germantown, MD)] compared with influenza virus polymerase chain reaction (PCR) assays. Patients seeking treatment for influenza-like-illness (ILI) in the outpatient setting were identified between October 17, 2010 and May 31, 2011. A total of 1,481 ILI patients were seen. Nasal specimens were collected and tested on all assays for 253 of these patients. Sensitivity and specificity of each influenza and multiplex respiratory assay was calculated relative to a gold standard PCR assay. The self-reported symptom profiles of each organism identified in the respiratory pathogen panels were compared. The median patient age was 12 years (range: 0-89 years); 176 (70%) had one or more viruses detected in the nasal swab specimen. Sensitivity for influenza A was 92% (95% CI: 88-99%) for FilmArray® RP, 85% (95% CI: 81- 96%) for ResPlex™ II, and 38% (95% CI: 48-71%) for Rapid, with specificities of 99.5-100%. Sensitivity for influenza B was 85% (95% CI: 86-99%), 70% (95% CI: 66-90%) for ResPlex™ II, and 6% (95% CI: 0-23%) for Rapid, with specificities of 99.5-100%. A similar pattern was seen for noninfluenza viruses, with the FilmArray® RP assay being more sensitive and specific than the ResPlex™ II. The use of multiplex viral assays is becoming more common in point-of-care settings. In this study, the Idaho Technology FilmArray® Respiratory Panel was more sensitive and specific than the Qiagen ResPlex™ II assay for influenza A and B viruses, as well as other common respiratory viruses.
Sonnenfleckenzeichnung Nr. 23681.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 17.06.1971, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1971

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Additional file 1 of Coding transcriptome analyses reveal altered functions underlying immunotolerance of PEG-fused rat sciatic nerve allografts
Creators: name: Smith, Tyler A.
name: Ghergherehchi, Cameron L.
name: Tucker, Haley O.
name: Bittner, George D.
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Fig. S1. (FigS1_Exp_Design.pdf). Outline of the experimental design of the study. PEG-fused sciatic nerve allografts (“PEG”, n=3 animals), negative control sciatic nerve allografts (“NC”, n=3 animals) from outbred Sprague Dawley rats were excised and sampled 14d post-operatively. Both treatment groups were compared to Unoperated Control sciatic nerves (“Unop”, n=2 animals). Total RNA was extracted from each sample via homogenization with TRIzol (Ambion) and a RNeasy Mini kit (Qiagen). Libraries were prepared using a TruSeq Stranded mRNA kit (Illumina), which were then sequenced on a HiSeq 3000 unit (Illumina). Analysis of read results was carried out sequentially by FastQC, Tophat2, HTSeq-count, and DESeq2 software. Subsequent analyses were performed via DAVID and the STRING application for Cytoscape software. Validation of candidate genes was performed via RT-qPCR, using the same treatment groups.
Activation of small molecules by cationic transition metal atoms and oxides
Creators: name: Chen, Yumin
Publisher: name: University of Utah
Year: 2012
Subjects: Transition metal compounds
Methane
Molecular dynamics

description: Guided ion beam mass spectrometry techniques are used to study the gas-phase ion-molecule reactions of hydrogen and oxygen molecules with second row transition metal ions, M+ = Y+, Ru+, Rh+, Pd+, and Ag+, as well as the reactions of Rh+ and Ag+ with several small alkanes. The cross sections for the observed reactions are measured as a function of kinetic energy of the reactants. The energetics associated with these cross section data are used to derive metal-hydrogen, metal-oxygen, and metal-carbon bond dissociation energies. Analysis of the periodic trends in the metal-hydrogen bond dissociation provides insight into the bonding character of these bonds. Reaction mechanisms are proposed on the basis of isotopic studies in the hydrogen systems or the energy dependence observed for the other systems. The reactivity differences among the various metal systems are understood by using molecular orbital ideas. Additional studies of the reactions of CoO+ with D2 and CH4, FeO+ with D2, and the D2O with Sc+ and Ti+ are mainly designed to probe the potential energy surfaces related to transferring an oxygen atom into the D-D and C-H ?-bonds, and to examine how the reactivity is affected by attaching an oxygen atom to a metal cation, thereby changing the electronic configuration at the metal.
Sonnenfleckenzeichnung Nr. 23745.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.08.1971, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1971

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Benchmarking dialectical behavior therapy for male veterans with posttraumatic stress disorder: a pilot study
Creators: name: Averill, Lynnette Astrid
Publisher: name: University of Utah
Year: 2012
Subjects: Dialectical behavior therapy
Post-traumatic stress disorder

description: This pilot study examined the application and effectiveness of Dialectical Behavior Therapy (DBT) as a treatment for male combat veterans with Posttraumatic Stress Disorder (PTSD). Participants (n=8) were recruited from the Veterans Affairs Salt  Lake City Health Care System (VASLCHCS) after seeking mental health services for PTSD symptoms. Veterans completed the Clinician Administered PTSD Scale (CAPS) as well as a battery of self-report questionnaires meant to assess a broad spectrum of PTSD symptomology including depressive symptoms, suicidal ideation, anger, sleep disturbance, avoidant behaviors, increased arousal, and hypervigilance as well as general wellbeing. After preassessment, veterans attended a DBT PTSD Coping Skills Group  facilitated by staff members (clinical staff and graduate level trainees) at the VASLCHCS  for a minimum of 10 weeks. Upon completion of this group, veterans were administered all post treatment assessment protocols. Matched pairs /-tests were conducted for each of the nine assessments used in the present study. Four outcome measures (the CAPS, BDI, M-PTSD and STAXI-2 AX/O) showed statistically significant change between pre- and postassessment. Additionally, a benchmark was conducted using data from published treatment studies for PTSD. Due to a small sample size in the observed data, no statistical analysis was possible; however,  effect size results from the observed data were visually compared against aggregated results of the benchmark. This comparison showed the effect sizes of the observed data were equivalent to or greater to those of the benchmark. Implications for future research and clinical practice are discussed as well as the study limitations.
Sonnenfleckenzeichnung Nr. 23704.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 11.07.1971, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1971

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Amblyoproctus piliger
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Amblyoproctus
Amblyoproctus piliger

description: Amblyoproctus piliger (Perty, 1830)
Phileurus piliger Perty 1830: 44 (Brazil)
= Phileurus pusio Erichson 1848: 561 (Guyana - LECTOTYPE)
Distribution. Guyana: Erichson 1848: 561 (as Phileurus pusio); Endrödi 1977c: 40 (designation LEC- TOTYPE Phileurus pusio). French Guiana: Endrödi 1977c: 40, 1985a: 707; Ratcliffe 1988: 45; Lachaume 1992: 52; Brûlé et al. 2011a: 191; Duranton 2011: 23; Ponchel 2011: 61; Dupuis 2016b: 110. “Guianas”: Arrow 1937b: 91; Blackwelder 1944: 259. Brazil (NA): Perty 1830: 44 (as Phileurus piliger); Endrödi 1977c: 40, 1985a: 707; Ratcliffe 1988: 45 (NA); Lachaume 1992: 52. Other: Arrow 1937b: 91 (Ecuador, Peru); Blackwelder 1944: 259 (Ecuador, Peru); Endrödi 1977c: 40 (Ecuador, Peru), 1985a: 707 (Ecuador, Peru); Ratcliffe 1988: 45 (Colombia, Ecuador, Peru); Lachaume 1992: 52 (Ecuador, Peru).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 216, DOI: 10.5281/zenodo.3678492
Narrative and language use: how mothers regard school-aged children
Creators: name: Ludlow, Amy
Publisher: name: University of Utah
Year: 2013
Subjects: ADHD
Biases
Listeners' perceptions
Narrative
SLI
Specific language impairment

description: Previous research documents the tendency for listeners to assign negative attributes to children with communication disorders. However, variability within rater groups has been large across studies. Factors that influence ratings remain unaccounted for. In this study, 60 mothers rated 1-minute narratives produced by matched child speakers with specific language impairment (SLI), attention deficit hyperactivity disorder (ADHD), and typical development (TD). It was predicted that mothers who have a child with a disability (MWCD) would be more sensitive to the consequences of negative biases and would be less inclined to assign pejorative ratings to child speakers with communication disorders than mothers whose children only have typical development (MWCTD). Participant groups were matched for age, educational level, family size, and race/ethnicity. After hearing each sample, participants provided ratings in response to 20 questions about each speaker's narrative and a 16-item questionnaire providing details about their personal experiences with individuals with disabilities. Narrative questions included information about the actual narrative, child speaker attributes, and parent/family attributes. A 2 (MWCTD, MWCD) X 3 (SLI, ADHD, TD) mixed model ANOVA revealed statistically significant main effects within group (SLI, ADHD, TD). Analyses revealed that ratings for the TD speaker were significantly higher (i.e., "better") than the SLI and ADHD speaker ratings such that ADHD=SLI < TD or ADHD < SLI < TD. The pattern of ADHD < SLI < TD was found for questions related to narrative form and behavioral attributes. No significant effects were found for the between groups variable or for the group x speaker interaction. Overall age, education level, and exposure to disabilities predicted ratings but having a child with disability did not. Raters seemed to be very sensitive to features present in the ADHD speaker's narrative that marked him as having behavioral difficulties. Another surprising outcome was the lack of differences between ratings of narrative form assigned to the two clinical speakers, given that the narrative produced by the SLI speaker contained numerous grammatical errors. It appears that listeners do not differentiate grammatical problems from other problems with form (phonology, fluency). Clinical implications are discussed.
A lymphocyte-targeting polymeric drug delivery system mediated by receptor-binding epitopes: design, synthesis, and characterization.
Creators: name: Tang, Aijun
Publisher: name: University of Utah
Year: 2012
Subjects: Pharmaceutical Preparations
Drug Delivery Systems

description: Extensive studies have demonstrated that the use of targetable polymeric drug delivery systems is an efficient approach for improving cancer chemotherapy. In this dissertation, a new strategy for the design of targetable polymeric anticancer drug carriers was proposed that combined water-soluble polymers with epitopes recognizing cell surface receptors. The research investigated the biorecognizability of receptor-binding epitopes presented on structure-simplified peptide templates, and explored the feasibility of transplanting these epitopes to a water-soluble polymer conjugate system for receptor-specific recognition of target cells.  The specific objectives of this project were accomplished in three steps. The first step was model establishment. A peptide template containing a nonapeptide epitope as a ligand for B cell CD21 receptor was designed and synthesized by genetic engineering methods. The peptide was immobilized on a solid substrate in an oriented manner and the recognizability of the epitope was evaluated. The results demonstrated the applicability of this model system to display epitopes for biorecognition studies. In the second step, a series of nonapeptide-related peptides were incorporated into a coiled coil stem loop peptide template, and the recognition of these peptides was studied using isolated receptor and receptor-bearing cells. These peptides exhibited varying receptor-binding affinities, thereby revealing their potential as targeting moieties. The last step focused on the synthesis of epitope-containing polymer conjugates and evaluation of their recognizability and cytotoxicity using experimental cell lines. It was found that the epitopes induced specific binding of the conjugates to the target cells and significantly enhanced the cytotoxic activity of polymer-bound doxorubicin.  This work describes a potential strategy toward the targeted delivery of anticancer drugs to a subset of lymphocytes for the treatment of lymphoma and leukemia. It is speculated that the combination of water-soluble polymers with receptor-binding epitopes may be applicable to other ligand-receptor systems, and that polymer-based therapeutics can be tailored to specific malignancies.