cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Methaemoglobin and COHb in patients with malaria
Creators: name: Hänscheid, Thomas
name: Gresnigt, Tom
name: Löhr, Sascha
name: Flamen, Arnaud
name: Zoller, Thomas
name: Melo-Cristino, José
name: Grobusch, Martin P.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Haemolytic conditions may contribute to disease pathogenesis and severe clinical manifestations through the liberation of free haemoglobin (Hb) and production of toxic free haem. Thus, free Hb and haem should be associated with altered MetHb and COHb levels in malaria as in other conditions. Methods This study comprises data collected at three different sites: (i) a retrospective analysis of the first arterial blood gas result (ABGS) of any patient during 2010 at the University Hospital in Lisbon; (ii) a retrospective analysis of ABGS from patients with severe malaria admitted to the intensive care unit in Berlin, Germany; and (iii) a prospective study of non-invasive MetHb measurements in children with and without malaria in Lambaréné, Gabon. Results In Lisbon, the mean MetHb level was 1.4% (SD: 0.5) in a total of 17,834 ABGS. Only 11 of 98 samples with a MetHb level of >3.0 referred to infections. COHb levels showed no particular association with clinical conditions, including sepsis. In 13 patients with severe malaria in Berlin, the mean MetHb levels on admission was 1.29%, with 1.36% for cerebral malaria and 1.14% for non-cerebral malaria (P > 0.05). All COHb measurements were below 2.3%. In Lambaréné, Gabon, 132 healthy children had a mean MetHb level of 1.57%, as compared to 150 children with malaria, with a value of 1.77% and 2.05% in uncomplicated and complicated cases, respectively (P
Editorial: Immunotherapy in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)
Creators: name: Jamy, Omer
name: Zeidner, Joshua
name: Zhou, Fuling
Publisher: name: Frontiers Media SA
Year: 2024

description: Harnessing the immune system to treat cancer was first described by Dr. William Coley in the 1890's after he developed a Streptococcal toxin to treat metastatic Sarcoma patients.(1) Dr. Coley's omniscience, however, did not translate clinically until almost a century later whereby immunotherapy approaches have led to a paradigm shift in the management of many solid tumors and hematologic malignancies. Allogeneic stem cell transplantation (alloSCT) has offered the ability to cure patients with high-risk hematologic malignancies via a known immunologic-based graft-versus-leukemia effect. Other immunotherapy approaches for hematologic malignancies have mainly been limited to B-cell neoplasms with bispecific T-cell engagers (BiTEs) for acute lymphoblastic leukemia (ALL), chimeric antigen receptor (CAR) T cells for ALL and lymphoma and immune checkpoint inhibitors (ICPIs) for lymphoma. (2) In the past decade, we have made significant progress in understanding the biology of acute myeloid leukemia (AML) and ALL, including studying the underlying immune systems at play. (3) This has led to the investigation of innovative T-cell-based treatment strategies for these diseases. Within this context, we created this research topic to welcome studies on further understanding the immune landscape of AML and ALL, along with both pre-clinical and clinical data of immunotherapy in these settings and its implication in the real-world.A breakthrough in the treatment of AML has been the approval of venetoclax (VEN), a BCL-2 inhibitor. In conclusion, our topic highlights the keen interest of exploring the tumor immune microenvironment, in AML and ALL, to better understand disease biology, risk stratification and response to therapy. We also observe that these findings are being translated into clinical studies to treat challenging entities such as r/r AML and T-cell ALL, indicating the promising potential of immunotherapy in leukemia harking back to the clairvoyant observations by Dr. Coley over 130 years ago.
Transit-oriented design research for an improved multimodal EV bus system for Malaysia 2020
Creators: name: Kuys, Jung-Ok (Jo)
Publisher: name: Swinburne
Year: 2024

description: This research provides structured recommendations for the Malaysian government to prioritise an improved, sustainable electric bus system with an aim of increasing patronage for the ailing public transportation network. This is done through observational research identifying public needs, engineering collaboration promoting sustainability and transit orientated design to improve the MTR multimodal logic. A research-led industrial design approach is used to present a design outcome encompassing the research findings.
Photolysis of the tetrazole ring.
Creators: name: Haque, Kazi Enamal.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1966
Subjects: subject: Chemistry, Analytical.

description: The preparation of 5-ethoxycarbonyltetrazole, 5-phenyltetrazole, 1-methyl-5-phenyltetrazole, 2-methyl-5-phenyltetrazole, 5-p-nitrophenyltetrazole, 1-methyl-5-p-nitrophenyltetrazile, 2-methyl-5-p-nitrophenyltetrazole, 1-methyl-3,5-diphenyl-1,2,4-triazole and 2-methyl-4,5-diphenyl-1,2,3-triazole have been described. Photolysis of 5-phenyltetrazole produces 3,6-diphenyl-s-tetrazine and 1,4-dihydro-3,6-diphenyl-s-tetrazine, whereas the latter undergoes smooth oxidation with bromine producing 3,6-diphenyl-s-tetrazine. Several attempts were made to trap the possible nitrilimine intermediate by photolysing 5-phenyltetrazole in the presence of norbornene and ethyl acrylate, but in neither case was any pyrazoline derivative obtained. The production of 1-4-dihydro-3,6-diphenyl-s-tetrazine through the possible photodimer or free radicals formations has also been discussed. Photolysis of 2-methyl-5-phenyltetrazole produces 2-methyl-4,5-diphenyl-1,2,3-triazole in addition to some other yet unidentified products. The structure of 2-methyl-4,5-diphenyl-1,2,3-triazole has been confirmed by its independent synthesis starting from benzil. Several attempts were made to trap the possible C-phenyl-N-methyl-nitrilimine by photolysing 2-methyl-5-phenyltetrazole with benzonitrile, but no change in the total yield of 1,2,3-triazole derivative was observed. The formation of 2-methyl-4,5-diphenyl-1,2,3-triazole through a possible photodimer of 2-methyl-5-phenyltetrazole has also been assumed. As 2-methyl-4,5-diphenyl-1,2,3-triazole on heating up to 220-225° for 6 hours did not produce any 1-methyl-3,5-diphenyl-1,2,4-triazole, the idea of the formation of 1-methyl-3,5-diphenyl-1,2,4-triazole via 2-methyl-4,5-diphenyl-1,2,3-triazole during the thermolysis of 2-methl-5-phenyltetrazole was given up. It has been shown, by using the Vycor filter, that radiations above 2400 A are responsible for effecting the photolysis of 2-methyl-5-phenyltetrazole. Several attempts were made to effect the photolysis of 1-methyl-5-phenyltetrazole by direct irradiation and once with the sensitizer, benzophenone, but in all cases 1-methyl-5-phenyltetrazole was found to be stable towards ultraviolet irradiation. 2-methyl-5-p-nitrophenyltetrazole, which has been isolated in 93% yield by methylation of 5-p-nitrophenyltetrazole, has been found to be stable towards the direct ultraviolet irradiation. The magnetic anisotropy-effects on the ortho protons of the phenyl rings of 2-methyl-5-phenyltetrazole, 5-phenyltetrazole, 5-p-nitrophenyltetrazole, 2-methyl-5-p-nitrophenyltetrazole and 1-methyl-3,5-diphenyl-1,2,4-triazole and 3,6-diphenyl-s-tetrazine have been discussed. Infrared, ultraviolet and n.m.r. spectra were used extensively in the structure determinations of these compounds.
Manuscripts, Meat, and Medievalism
Creators: name: Ludwig, Bailey
Publisher: name: Brandeis University
Year: 2026
Subjects: cannibalism
chivalry
curation
eating
gender
masculinity
French literature

description: This dissertation portfolio is comprised of three distinct projects: “Material Features” (a CURIOSity curated feature page), “Consuming Courtliness” (essay), and “Martyrdom and Consumption in Everyone Knows I am a Haunting” (essay). The two essays utilize critical eating and food studies to explore the uses of food and consumption to construct identity in medieval romance and contemporary medievalism. “Consuming Courtliness” considers parallel food references in two romances, Béroul’s Le Roman de Tristran and Chrétien de Troyes’ Yvain ou le Chevalier au Lion, and their construction of a courtly diet. Building on this, the essay turns to medieval depictions of cannibalism, butchery, and hunting alongside these courtly food descriptions to analyze the flaying of the giant Harpin in Yvain. These romances suggest that eating is an act that helps to construct courtly identity, and sometimes a courtly diet involves the consumption or butchery of human bodies. The second essay explores medievalism in Shivanee Ramlochan’s poetry collection Everyone Knows I am a Haunting. Using theoretical approaches outlined by Omise’eke Natasha Tinsley, Joy Ellison, and Nicholas Hoffman, I argue that Ramlochan uses the medievalism to challenge the efficacy of martyrdom, virginity, and fasting in a contemporary Trinidadian context. “Material Features,” the digital portion of this dissertation portfolio, offers an introduction to the production and use of medieval manuscripts using digitized materials from Houghton Library. Using form/genre headings to record material features in manuscripts with teaching value, I sorted the digitized materials into four CURIOSity subpages: Bindings, Pages, Content, and Decoration. Each page discusses a series of related features and provides introductory-level explanations of key vocabulary terms, links to outside resources, and relevant items from Houghton’s collections.
Termikus eljárással működő hulladékhasznosító berendezés létrehozása GINOP-2.1.7-15-2016-00155
Creators: name: EUROINVESTMETAL Kereskedelmi és Szolgáltató Kft.
Publisher: name: Zenodo
Year: 2025

description: A kutatás célja egy olyan hulladékhasznosító berendezés létrehozása, amely termikus eljárás révén működött, ezáltal alkalmas olyan anyagok kinyerésére a társított, illetve vegyes műanyag hulladékból, amely más úton nem lehetséges. A hőbontással működő berendezés segítségével még a szemmel nem látható alkotóelemek is felszínre  kerültek, majd a kezelés során a kémiai elemek kölcsönhatásba létnek, ezáltal kiválasztódtak és tovább hasznosítható nyersanyaggá alakulnak. Ezekből az anyagokból a továbbiakban villamos energia, üzemanyag, fűtőanyag és kenőolaj állítható elő. A technológia létrehozása nélkül ezek a hulladékok nem kerültek volna hasznosításra, így  a környezetet terhelve kerültek volna megsemmisítésre. Ezáltal a projekt megvalósítása, nemcsak cégünk életében jelent komoly előrelépést, hanem a hulladékgazdálkodási iparágra és ezáltal a környezetvédelemre is pozitív hatással bír.
La table mystique des guermantes.
Creators: name: Fournier, Michel Pierre.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Literature, Modern.

description: L'itinéraire du héros de À la recherche du temps perdu , qui, au terme de son cheminement, le conduit à prendre conscience de sa vocation d'écrivain, correspond à une double évolution, à la fois artistique et sociale. Comment, sur le plan thématique, s'articulent précisément, dans l'oeuvre de Proust, les rapports entre l'initiation sociale de Marcel au monde aristocratique et son initiation à l'art? Telle est la question que pose cette étude et à laquelle elle s'efforce de répondre en montrant que le roman proustien laisse apparaître un complexe thématique à trois termes (art, religion et aristocratie), dont elle analyse les rapports. Il paraît en effet fructueux, dès lors que Proust use d'une métaphore religieuse pour décrire l'une et l'autre de ces deux initiations, de chercher à éclaircir leurs rapports en s'appliquant successivement, pour chacune d'entre elles, à élucider la cation de cette figure de style. Le sens et le rôle que Proust attribue notamment à l'art en reçoit peut-être un éclaircissement supplémentaire, d'où il ressort, entre autres choses, que l'inspiration biblique et évangélique est particulièrement marquée dans l'oeuvre de Proust.
Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b
Creators: name: Ebata, Kevin T
name: Mesh, Kathryn
name: Liu, Shichong
name: Bilenky, Misha
name: Fekete, Alexander
name: Acker, Michael G
name: Hirst, Martin
name: Garcia, Benjamin A
name: Ramalho-Santos, Miguel
Publisher: name: BioMed Central
Year: 2018

description: Background: Histone methylation patterns regulate gene expression and are highly dynamic during development. The erasure of histone methylation is carried out by histone demethylase enzymes. We had previously shown that vitamin C enhances the activity of Tet enzymes in embryonic stem (ES) cells, leading to DNA demethylation and activation of germline genes. Results: We report here that vitamin C induces a remarkably specific demethylation of histone H3 lysine 9 dimethylation (H3K9me2) in naïve ES cells. Vitamin C treatment reduces global levels of H3K9me2, but not other histone methylation marks analyzed, as measured by western blot, immunofluorescence and mass spectrometry. Vitamin C leads to widespread loss of H3K9me2 at large chromosomal domains as well as gene promoters and repeat elements. Vitamin C-induced loss of H3K9me2 occurs rapidly within 24 h and is reversible. Importantly, we found that the histone demethylases Kdm3a and Kdm3b are required for vitamin C-induced demethylation of H3K9me2. Moreover, we show that vitamin C-induced Kdm3a/b-mediated H3K9me2 demethylation and Tet-mediated DNA demethylation are independent processes at specific loci. Lastly, we document Kdm3a/b are partially required for the upregulation of germline genes by vitamin C. Conclusions: These results reveal a specific role for vitamin C in histone demethylation in ES cells and document that DNA methylation and H3K9me2 cooperate to silence germline genes in pluripotent cells.
Reproductive health status in Sub-Saharan Africa: 1990–2016
Creators: name: Woldegiorgis, Mulu Abraha
Publisher: name: Swinburne
Year: 2024

description: The overall aim of this study was to investigate the reproductive health status including progress, level of inequity and contributing factors in Sub-Saharan Africa region for a period of 25 years. While reproductive health implies that all women should have access to safe and affordable obstetric care, birth control and healthcare services, this is not the case in Sub-Saharan Africa. The data was mainly taken from a large sample size, nationally representative surveys of each country. The suggested strategies and recommendations are designed to inform different stakeholders including policy makers and researchers in the area of reproductive health.
Investigation of Bose-Einstein condensation effects with excitons in Cu₂2O.
Creators: name: Massé, Mathieu.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Physics, Condensed Matter.

description: Experimental observations are presented on Bose-Einstein condensation of excitons in Cu2O at low temperatures. These observations deal with traveling exciton packets in a high quality natural crystal. The properties of the exciton packets are examined using two different excitation depths of formation of the excitons (affecting the size of initial exciton cloud). The properties of the condensate include for example: the amplitude, the velocity of the exciton packet, the critical conditions for condensation and phase diagram. Interference effects of two coherent packets are also studied using these different initial excitation depths. Stimulated emission of particles into the exciton packet by injection of thermal excitons in the crystal volume is investigated in greater detail as well as the attenuation of the lateral laser beam (used to create the thermal excitons that trigger the amplification phenomenon).
Sugar Metabolism in Hummingbirds and Nectar Bats
Creators: name: Suarez, Raul Kamamtigue, 1952-
name: Welch, Kenneth C.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Hummingbirds and nectar bats coevolved with the plants they visit to feed on floral nectars rich in sugars. The extremely high metabolic costs imposed by small size and hovering flight in combination with reliance upon sugars as their main source of dietary calories resulted in convergent evolution of a suite of structural and functional traits. These allow high rates of aerobic energy metabolism in the flight muscles, fueled almost entirely by the oxidation of dietary sugars, during flight. High intestinal sucrase activities enable high rates of sucrose hydrolysis. Intestinal absorption of glucose and fructose occurs mainly through a paracellular pathway. In the fasted state, energy metabolism during flight relies on the oxidation of fat synthesized from previously-ingested sugar. During repeated bouts of hover-feeding, the enhanced digestive capacities, in combination with high capacities for sugar transport and oxidation in the flight muscles, allow the operation of the “sugar oxidation cascade”, the pathway by which dietary sugars are directly oxidized by flight muscles during exercise. It is suggested that the potentially harmful effects of nectar diets are prevented by locomotory exercise, just as in human hunter-gatherers who consume large quantities of honey.
Editorial: Special Issue “From Waste to Energy: Anaerobic Digestion Technologies”
Creators: name: Boutikos, Panagiotis
name: Aragón-Briceño, Christian
name: Manga, Musa
Publisher: name: MDPI
Year: 2024

description: Anaerobic digestion (AD) has become a cornerstone in the global pursuit of sustainable energy solutions and effective waste management. This Special Issue, “From Waste to Energy: Anaerobic Digestion Technologies,” highlights significant progress and innovative approaches aimed at addressing critical challenges in the AD process, including enhancing methane production, optimizing feedstocks, and integrating emerging technologies to increase efficiency and sustainability.
Restoration of documents with show-through distortion.
Creators: name: Pathak, Anita.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Information Science.

description: This thesis addresses the problem of show-through in old manuscripts and documents. After removing the show-through these documents can be stored in the digital libraries and will be accessible by everybody via Internet. The solution to this problem utilizes the image restoration technique. To apply this, the documents are scanned from each side and stored in a digital form. The two sides of document are called recto and verso images. To approach an apposite solution a basic model of the degradation is defined for these two images and then this model is used to eliminate the show-through. The technique for the enhancement is divided into two parts---first, achieving the most precise registration technique and secondly, to compute a method of restoration using the model of degradation. Four different techniques for registration are compared to select the most suitable method for this problem. This comparison brings forth the affine transformation approach to register the image. An approach for the restoration of the registered images is defined to eliminate the show-through from the document and save it in a digital library.
Nucleotide-Oligomerization-Domain-2 Affects Commensal Gut Microbiota Composition and Intracerebral Immunopathology in Acute Toxoplasma gondii Induced Murine Ileitis
Creators: name: Heimesaat, Markus M.
name: Dunay, Ildiko R.
name: Alutis, Marie
name: Fischer, André
name: Möhle, Luisa
name: Göbel, Ulf B.
name: Kühl, Anja A.
name: Bereswill, Stefan
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie

description: Background Within one week following peroral high dose infection with Toxoplasma (T.) gondii, susceptible mice develop non-selflimiting acute ileitis due to an underlying Th1-type immunopathology. The role of the innate immune receptor nucleotide-oligomerization-domain-2 (NOD2) in mediating potential extra-intestinal inflammatory sequelae including the brain, however, has not been investigated so far. Methodology/Principal Findings Following peroral infection with 100 cysts of T. gondii strain ME49, NOD2-/- mice displayed more severe ileitis and higher small intestinal parasitic loads as compared to wildtype (WT) mice. However, systemic (i.e. splenic) levels of pro-inflammatory cytokines such as TNF-α and IFN-γ were lower in NOD2-/- mice versus WT controls at day 7 p.i. Given that the immunopathological outcome might be influenced by the intestinal microbiota composition, which is shaped by NOD2, we performed a quantitative survey of main intestinal bacterial groups by 16S rRNA analysis. Interestingly, Bifidobacteria were virtually absent in NOD2-/- but not WT mice, whereas differences in remaining bacterial species were rather subtle. Interestingly, more distinct intestinal inflammation was accompanied by higher bacterial translocation rates to extra- intestinal tissue sites such as liver, spleen, and kidneys in T. gondii infected NOD2-/- mice. Strikingly, intracerebral inflammatory foci could be observed as early as seven days following T. gondii infection irrespective of the genotype of animals, whereas NOD2-/- mice exhibited higher intracerebral parasitic loads, higher F4/80 positive macrophage and microglia numbers as well as higher IFN-γ mRNA expression levels as compared to WT control animals. Conclusion/Significance NOD2 signaling is involved in protection of mice from T. gondii induced acute ileitis. The parasite-induced Th1-type immunopathology at intestinal as well as extra-intestinal sites including the brain is modulated in a NOD2-dependent manner.
The role of N-terminal domain in regulation of mineralocorticoid receptor function
Creators: name: Swan, Katherine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Biology, Molecular.

description: The N-terminal domain of the mineralocorticoid receptor (MR) exhibits no significant sequence homology to the highly related glucocorticoid receptor. I report here that amino acids 450--602 of the N-terminus play a role in three aspects of MR degradation: (1) degradation in the absence of aldosterone mediated by the 26S proteasome, (2) degradation in the presence of aldosterone mediated by the 26S proteasome, and (3) degradation in the presence of aldosterone not mediated by the 26S proteasome. Concurrently I determined that aldosterone treatment following transient expression of MR in Cos-7 cells induced the appearance of higher molecular weight forms of the receptor. I determined that two regions within the N-terminus of MR were required for the appearance of the aldosterone-stimulated shift in molecular weight. Furthermore, the type of agonist, nuclear occupancy and the cell type employed influenced the shift in molecular weight of MR.
Beyond Boundaries of Blackness: The Racialization, Identification, and Perception of the Israeli Black Panthers
Creators: name: Souza, Leighton Danielle
Publisher: name: Brandeis University
Year: 2024
Subjects: Blackness
Israeli Black Panthers
Mizrahi
Race/Racism
Israel
History

description: This thesis examines the role of race in the State of Israel by exploring how Blackness manifested through the State’s Mizrahi population. Blackness was both ascribed by the State unto Mizrahim, as well as adopted by some Mizrahim, namely the Israeli Black Panthers. Established in 1971, the Israeli Black Panthers utilized race in their fight against state and societal discrimination, leaving one to question the depth and weight of the term “Black” in Israeli society. Locating itself in the mid-to-late twentieth century, this paper begins by laying the foundation of the arrival of Mizrahim to the State of Israel and their subsequent discrimination that persisted in the decades that followed. Israel racialized Mizrahim as Black, but only after Europe racialized Ashkenazim – once Ashkenazim began forming their own society in the likes of the West, they othered Mizrahim in order to align themselves with whiteness. The racialization of Mizrahim, in conjunction with specific acts of racial discrimination, then provides the much-needed background in understanding how and why Mizrahim would align themselves with a Black Power movement from the United States. The Mizrahim involved in the Israeli Black Panthers identified with and adopted Blackness for a cause that they saw existed both within and far beyond their national boundaries, carving out a place for themselves within this historical narrative of global Blackness. Reclamatory in nature, their identity can sometimes be seen vacillating between Black and white, as typically occurs in oppressed-oppressor relationships. The transnational nature of this topic leads one to question how the Israeli Black Panthers were perceived by those outside of Israel, specifically in terms of Blackness. American and Jewish-American newspapers provide insight to the citizenry’s wide-ranging viewpoints, such as ambiguous, receptive, and rejective, with most more likely to reject the Israeli Black Panthers’ Black identity. This thesis strives to display the lived realities of Mizrahim through underlining their agency via acts of resistance. Through the inclusion of Mizrahim in conversations around race, and the portrayal of the similarities of the Black-white divide in the United States and the Mizrahi-Ashkenazi divide in Israel, a clearer picture of the commonalities between oppressive systems and the ways in which race consciousness forms may emerge.
Cardiac and renal function in a large cohort of amateur marathon runners
Creators: name: Hewing, Bernd
name: Schattke, Sebastian
name: Spethmann, Sebastian
name: Sanad, Wasiem
name: Schroeckh, Sabrina
name: Schimke, Ingolf
name: Halleck, Fabian
name: Peters, Harm
name: Brechtel, Lars
name: Lock, Jürgen
name: Baumann, Gert
name: Dreger, Henryk
name: Borges, Adrian C.
name: Knebel, Fabian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Participation of amateur runners in endurance races continues to increase. Previous studies of marathon runners have raised concerns about exercise-induced myocardial and renal dysfunction and damage. In our pooled analysis, we aimed to characterize changes of cardiac and renal function after marathon running in a large cohort of mostly elderly amateur marathon runners. Methods A total of 167 participants of the BERLIN-MARATHON (female n = 89, male n = 78; age = 50.3 ± 11.4 years) were included and cardiac and renal function was analyzed prior to, immediately after and 2 weeks following the race by echocardiography and blood tests (including cardiac troponin T, NT- proBNP and cystatin C). Results Among the runners, 58% exhibited a significant increase in cardiac biomarkers after completion of the marathon. Overall, the changes in echocardiographic parameters for systolic or diastolic left and right ventricular function did not indicate relevant myocardial dysfunction. Notably, 30% of all participants showed >25% decrease in cystatin C-estimated glomerular filtration rate (GFR) from baseline directly after the marathon; in 8%, we observed a decline of more than 50%. All cardiac and renal parameters returned to baseline ranges within 2 weeks after the marathon. Conclusions The increase in cardiac biomarkers after completing a marathon was not accompanied by relevant cardiac dysfunction as assessed by echocardiography. After the race, a high proportion of runners experienced a decrease in cystatin C-estimated GFR, which is suggestive of transient, exercise-related alteration of renal function. However, we did not observe persistent detrimental effects on renal function.
A multi-method investigation of circadian rhythms, sleep, and affective states: characterising modulation, imaging reward mechanisms, and improving clinical measurement
Creators: name: Byrne, Jamie E. M.
Publisher: name: Swinburne
Year: 2024

description: The current findings advance evidence of a relationship between biological rhythms and reward motivation in humans at multiple biobehavioural levels. This project has psychometrically quantified the separation of biological rhythms and mood leading to the generation and initial psychometric testing of a new self-report measure of sleep quality, diurnal preference, and mood. In addition, this project has found evidence for diurnal variation of reward motivation, a preliminary step in investigating modulation of reward motivation by circadian functioning. Future research should systematically investigate the relationships between the multifaceted construct of reward motivation and the range of processes involved in biological rhythms.
Multi-feed spatial power combining reflectarrays
Creators: name: Arpin, Frederic N
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Engineering, Electronics and Electrical.

description: In order to have increased bandwidth, future wireless communications systems will use millimeter-wave frequencies. Such systems will require antennas with relatively high gain and sources with sufficient power. Spatial power combining provides an attractive alternative to these issues. This thesis develops a means of combining the antenna and spatial power-combining functions in a single device. We formulate a design procedure that allows multiple feeds to illuminate a reflectarray that will give a single-beam. The reflectarray acts both as a spatial-power combiner and as the antenna. Unlike previous work that has been done on spatial power-combining reflectarrays, the proposed design does not involve the integration of any active devices. The new design procedure for a multi-feed spatial power-combining reflectarray was first applied to a two-feed reflectarray which was fabricated and tested as a proof of concept. (Abstract shortened by UMI.)
Applications of Ryu-Takayangi to asymptotically flat spacetimes
Creators: name: Gupta, Divij
Publisher: name: Brandeis University
Year: 2024
Subjects: Differential Geometry
Holography
Quantum Field Theory
Relativity

description: The Ryu-Takayangi formula provides an important relationship between minimal surfaces in the bulk and entanglement entropies of quantum field theories on the boundary. We provide an extension of this formula to asymptotically flat spacetimes. We first do this for the spherically symmetric Schwarzschild metric by gluing copies of SAdS (Schwarzschild-AdS) to either side using the Israel junction conditions. We then discuss the Brill-Lindquist initial data, which describes N colliding black holes that form an (N + 1)-boundary asymptotically flat wormhole geometry on a time symmetric Cauchy slice. We discuss some important properties and useful coordinates to study the metric, before exploring numerical meth- ods to compute and classify its extremal surfaces. This leads us into applying our RT extension to the asymptotically flat wormholes generated by the Brill-Lindquist metric. An example of this application is explored within the ER=EPR framework, where we study a holographic model for black hole evaporation by taking the Brill-Lindquist wormhole to represent the entanglement geometry of the evaporation pro- cess. The Page curve for the entanglement entropy is recovered for N = 2 and we also discuss properties of the Python’s lunch proposal within this model.
The ratio between cerebral blood flow and Tmax predicts the quality of collaterals in acute ischemic stroke
Creators: name: Galinovic, Ivana
name: Kochova, Elena
name: Khalil, Ahmed
name: Villringer, Kersten
name: Piper, Sophie K.
name: Fiebach, Jochen B.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background In acute ischemic stroke the status of collateral circulation is a critical factor in determining outcome. We propose a less invasive alternative to digital subtraction angiography for evaluating collaterals based on dynamic-susceptibility contrast magnetic resonance imaging. Methods Perfusion maps of Tmax and cerebral blood flow (CBF) were created for 35 patients with baseline occlusion of a major cerebral artery. Volumes of hypoperfusion were defined as having a Tmax delay of > 4 seconds (Tmax4s) and > 6 seconds (Tmax6s) and a CBF drop below 80% of healthy, contralateral tissue. For each patient a ratio between the volume of the CBF and the Tmax based perfusion deficit was calculated. Associations with collateral status and radiological outcome were assessed with the Mann-Whitney-U test, uni- and multivariable logistic regression analyses as well as area under the receiver-operator- characteristic (ROC) curve. Results The CBF/Tmax volume ratios were significantly associated with bad collateral status in crude logistic regression analysis as well as with adjustment for NIHSS at admission and baseline infarct volume (OR = 2.5 95% CI[1.2–5.4] p = 0.020 for CBF/Tmax 4s volume ratio and OR = 1.6 95% CI[1.0–2.6] p = 0.031 for CBF/Tmax6s volume ratio). Moreover, the ratios were significantly correlated to final infarct size (Spearman’s rho = 0.711 and 0.619, respectively for the CBF/Tmax4s volume ratio and CBF/Tmax6s volume ration, all p<0.001). The ratios also had a high area under the ROC curve of 0.93 95%CI[0.86–1.00]) and 0.90 95%CI[0.80–1.00]respectively for predicting poor radiological outcome. Conclusions In the setting of acute ischemic stroke the CBF/Tmax volume ratio can be used to differentiate between good and insufficient collateral circulation without the need for invasive procedures like conventional angiography.
The R102A Mutation Uncovers the Inhibitory Roles of ATP in Grp94
Creators: name: LaRussa, Salvatore Atkinson
Publisher: name: Brandeis University
Year: 2023
Subjects: Chaperone Proteins
Grp94
Hsp90

description: All Hsp90 chaperone proteins undergo an ATP-dependent conformational cycle that is essential for their activity. Unlike other Hsp90 paralogs, the endoplasmic reticulum Hsp90 paralog Grp94 builds up a steady-state closed state population under ATP turnover conditions, enabling study of both opening and closure rates. Introducing the opening-rate accelerating R102A mutation, previously partially characterized in the yeast cytosolic Hsp90 paralog Hsp82, into Grp94 allows me to characterize the effect of increasing the rate of ATP hydrolysis in an Hsp90 system. Grp94 has been previously observed to enter two different closed states observable via smFRET, a long-lived closed state followed by a short-lived higher-FRET closed state referred to as the C’ state, which is present immediately prior to reopening. I observed that the R102A mutant appears to close and open directly into the C’ state. This supports a previously proposed hypothesis that the C’ state is entered after hydrolysis of bound molecules of ATP. I also characterized ATP-concentration dependent substrate inhibition of Grp94. After finding that Mg2+ inhibits Grp94 in a concentration-dependent manner, and subsequently controlling for Mg2+ concentration, I was able to use the increased ATPase rate of R102A to characterize the ATP-concentration dependent substrate inhibition of Grp94. ATPase data were fit to a simple model where binding of a second molecule of ATP leads to a lower ATPase rate. Addition of the closure-accelerating nucleotide binding domain of the cochaperone BiP decreased the degree of substrate inhibition observed, and abolished inhibition completely in the context of R102A and K364A mutants, indicating that increased ATP concentrations inhibit Grp94 dimer closure. Taken together, these results illustrate how ATP is not only necessary for Grp94 activity, but also slows conformational changes through multiple independent mechanisms.
Sambey's Law: N+ξ = Reality
Creators: name: Sambey, Stanley Everett
Publisher: name: Zenodo
Year: 2025

description: Sambey’s Law (ICUF) boils down to N + ξ = reality: events (N ) plus coherence (ξ)create ordered systems, reset by sleep or inactivity. From quantum ( 10 events) to humanbrains ( 10¹ events/day, 1 × 10¹² bits), it predicts order—10² J/K, 10¹³ J/K—matchingreality. Consciousness edits futures, dreaming sorts the past, sleep keeps it simple. As clearas 1+1=2, this unifies everything. See zenodo.org/records/14956617 (DOI: 10.5281/zen-odo.14956617)
The role of imagery in the positive birth experience: An exploratory study.
Creators: name: Pitman, Anne.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Anthropology, Cultural.

description: The purpose of the present study was to explore the role of imagery in a positive birth experience, specifically with respect to the experience of vaginal birth after cesarean (VBAC). The quantity and quality of imagery used and its perceived value were explored. A VBAC Imagery Questionnaire was developed and sent to Ontario women known to have had a VBAC. The following types of imagery were explored; healing imagery, vaginal birth imagery, repeat cesarean imagery, "block point" imagery, "augmenting" imaging, other "uplifting" imagery and imagery experienced during the actual VBAC birth. Many women described their images as very positive and absorbing, and women rated all types of imagery as very helpful in achieving their vaginal birth after cesarean. Imagery was rated by women to be as helpful in the VBAC experience as vital changes made in health care professionals and location of labor and birth. (Abstract shortened by UMI.)
Eating Problems Among Adolescent Boys and Girls Before and During the Covid-19 Pandemic
Creators: name: Ask, Helga
name: Lund, Ingunn Olea
name: Brandlistuen, Ragnhild E.
name: Hannigan, Laurie
name: Gustavson, Kristin
name: Bulik, Cynthia M.
name: Pettersen, Johanne H.
name: Havdahl, Alexandra
name: Hegemann, Laura
name: Andreassen, Ole A.
name: Jensen, Pia
Publisher: name: Wiley Blackwell
Year: 2024

description: Objective Studies suggest that adolescents reported more eating problems during the pandemic. Using a population-based sample, we compared eating problems—and how they associate with a range of personal characteristics and genetic factors—among adolescents before (June 2017–April 2020) versus during (April 2020–December 2022) the pandemic. Method Based on a preregistered analysis plan, we used cross-sectional data collected from 22,706 14–16-year-olds over 6 years (55% during the pandemic) in the Norwegian Mother, Father, and Child Cohort. We used measurement invariance analyses to compare the level of eating restraint and body concern before and during the pandemic, and multi-group structural equation models to estimate pre-pandemic and pandemic patterns of associations. Results Pandemic responders generally reported more eating problems than pre-pandemic responders, specifically on dieting and body dissatisfaction. However, after adjusting for a general linear increase in eating problems across all 6 years of data collection, the pandemic itself seems to be associated with more eating problems only among girls, reporting more eating restraints (meanΔ = 0.14 [CI: 0.07, 0.20]) and body concern (meanΔ = 0.17 [CI: 0.11, 0.23]). Associations between eating problems and a range of other characteristics did not differ across the pandemic and pre-pandemic groups. Conclusions There was a general increase in eating problems among 14–16-year-olds over time. Adjusting for this trend, the pandemic seems to exacerbate problems among girls. Although the mechanisms are unclear, our results point to factors susceptible to change that could have been intensified during the pandemic (e.g., screen time, mental distress). Our results highlight the importance of recognizing sex-specific differences in eating problems.
Towards a self-reflection theory of choice behaviour: how reflecting on minimal choices can affect the self
Creators: name: Dishon, Noam
Publisher: name: Swinburne
Year: 2024

description: Traditional theories of choice have given little overt attention to the possible impact that self-reflection and meaning-making could have on the self-concept within a decision-making context. This thesis developed and tested a model capable of articulating pathways through which self-reflection and meaning-making might moderate the relationship between choice(s) and the self-concept. Across four experiments, the effect of self-reflection on the self-concept was consistently supported. The effect of choice meaningfulness however was less consistent. The present thesis has made a significant contribution to scientific knowledge by proposing and empirically testing the viability of a new model of choice behaviour.
OPEN DIGITAL HUMANITIES JOURNALS: REVISTA DE HUMANIDADES DIGITALES. A framework for the construction of an academic field
Creators: name: Martínez Cantón, Clara
name: del Rio, Gimena
name: De León, Romina
name: Priani Saisó, Ernesto
Publisher: name: Zenodo
Year: 2020
Subjects: Digital Humanities
Journals

description: OPEN DIGITAL HUMANITIES JOURNALS: REVISTA DE HUMANIDADES DIGITALES. A framework for the construction of an academic field
 Clara Martínez Cantón (UNED)
 Gimena del Río Riande (CONICET, Argentina)
 Romina De León (CONICET, Argentina)
 Ernesto PrianiSaisó(UNAM, México)
An Evolutionary and Structural Analysis of Type I Terpene Synthases
Creators: name: Black, Brandon
Publisher: name: Brandeis University
Year: 2024
Subjects: Ancestry
ASR
Epistasis
Specificity
Terpene
Evolution
Biochemistry

description: Terpene synthases (TPSs) produce the largest and most diverse class of natural products. They engage a small number of highly reactive substrates and perform complex intramolecular reactions such as anti-Markovnikov cyclizations. Previously our lab has shown that pentalenene synthase (PS) is dependent on F76 aromaticity for its concerted anti-Markovnikov reaction. This thesis addresses evolutionary questions concerning the emergence of anti-Markovnikov specificity for PS and two related TPSs. Using ancestral sequence reconstruction to define the evolutionary history of TPSs, I show that aromaticity was present at position 76 before anti-Markovnikov specificity emerged and that higher order epistasis activated F76 for pentalenene specificity. Using ancestral sequence reconstruction (ASR), I show reverse evolution occurring for the first time in a protein family among other unique evolutionary processes. Additionally, I report the first structures of caryolan-1-ol synthase with substrate analogue bound showing the multistep nature of its anti-Markovnikov mechanism compared to that of PS. Finally, I show that modern and ancestral TPSs can produce complex, polymethylated terpenes through incubation with methylated substrates. Studying the evolution of TPSs using ASR can not only aid in identifying residues and epistasis that control specificity, but also can contribute to molecular diversity by accessing novel products from ancestral sources.
De gauvreau à danis: Repérés pour une poétique de la langue théâtrale
Creators: name: Blonde, David
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Literature, Canadian (French).
subject: Theater.

description: Le théâtre québécois a trouvé son acte de naissance dans l'invention d'une langue, le joual. Qualifié pendant longtemps de langue naturaliste, étudié plus récemment pour sa littérarité, le joual est au nombre des langues poétiques québécoises qui font parler le corps du comédien et vibrer celui du spectateur, de l'exploreen de Claude Gauvreau à la "langue parolique" de Daniel Danis. La présente thèse examinera les procédés poétiques exploités par Michel Tremblay, Claude Gauvreau et Daniel Danis pour faire parler le corps du comédien, faire vibrer celui du spectateur et mettre en relief la langue "pour son propre compte (Roman Jakobson)": jeux de sonorités, variations rythmiques, compositions musicales, images.
Novel Flexible Wearable Sensor Materials and Signal Processing for Vital Sign and Human Activity Monitoring
Creators: name: Servati, Amir
name: Zou, Liang
name: Wang, Z. Jane
name: Ko, Frank K.
name: Servati, Peyman
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Advances in flexible electronic materials and smart textile, along with broad availability of smart phones, cloud and wireless systems have empowered the wearable technologies for significant impact on future of digital and personalized healthcare as well as consumer electronics. However, challenges related to lack of accuracy, reliability, high power consumption, rigid or bulky form factor and difficulty in interpretation of data have limited their wide-scale application in these potential areas. As an important solution to these challenges, we present latest advances in novel flexible electronic materials and sensors that enable comfortable and conformable body interaction and potential for invisible integration within daily apparel. Advances in novel flexible materials and sensors are described for wearable monitoring of human vital signs including, body temperature, respiratory rate and heart rate, muscle movements and activity. We then present advances in signal processing focusing on motion and noise artifact removal, data mining and aspects of sensor fusion relevant to future clinical applications of wearable technology.
Spirituality, naturalism, and agnosticism: investigating the principles and benefits of worldviews in psychology
Creators: name: Holmes, Oliver
Publisher: name: Swinburne
Year: 2024

description: Worldviews are systems of beliefs about the nature of reality. The current thesis used three studies with online surveys to develop psychometric measures for three worldviews - Spirituality, Naturalism, and Agnosticism. It tested these worldviews alongside personality traits, cognitive tendencies, and well-being variables. Findings showed that worldview beliefs could be incorporated into trait personality constructs, that they are influenced by relevant cognitive functions, and that they have diverse impacts on well-being outcomes. Implications were discussed in terms of theoretical principles of worldview psychology, and the practical and ethical issues involved with addressing and modifying worldview beliefs in clinical psychology.