cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Outcome prediction in aneurysmal subarachnoid hemorrhage: a comparison of machine learning methods and established clinico-radiological scores
Creators: name: Dengler, Nora Franziska
name: Madai, Vince Istvan
name: Unteroberdörster, Meike
name: Zihni, Esra
name: Brune, Sophie Charlotte
name: Hilbert, Adam
name: Livne, Michelle
name: Wolf, Stefan
name: Vajkoczy, Peter
name: Frey, Dietmar
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Aneurysmal subarachnoid hemorrhage
subject: Outcome prediction
subject: Deep learning
subject: Artificial neural net
subject: Tree boosting
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Reliable prediction of outcomes of aneurysmal subarachnoid hemorrhage (aSAH) based on factors available at patient admission may support responsible allocation of resources as well as treatment decisions. Radiographic and clinical scoring systems may help clinicians estimate disease severity, but their predictive value is limited, especially in devising treatment strategies. In this study, we aimed to examine whether a machine learning (ML) approach using variables available on admission may improve outcome prediction in aSAH compared to established scoring systems. Combined clinical and radiographic features as well as standard scores (Hunt & Hess, WFNS, BNI, Fisher, and VASOGRADE) available on patient admission were analyzed using a consecutive single-center database of patients that presented with aSAH (n = 388). Different ML models (seven algorithms including three types of traditional generalized linear models, as well as a tree bosting algorithm, a support vector machine classifier (SVMC), a Naive Bayes (NB) classifier, and a multilayer perceptron (MLP) artificial neural net) were trained for single features, scores, and combined features with a random split into training and test sets (4:1 ratio), ten-fold cross-validation, and 50 shuffles. For combined features, feature importance was calculated. There was no difference in performance between traditional and other ML applications using traditional clinico-radiographic features. Also, no relevant difference was identified between a combined set of clinico-radiological features available on admission (highest AUC 0.78, tree boosting) and the best performing clinical score GCS (highest AUC 0.76, tree boosting). GCS and age were the most important variables for the feature combination. In this cohort of patients with aSAH, the performance of functional outcome prediction by machine learning techniques was comparable to traditional methods and established clinical scores. Future work is necessary to examine input variables other than traditional clinico-radiographic features and to evaluate whether a higher performance for outcome prediction in aSAH can be achieved.
Clinical management and outcome of adult patients with extracorporeal life support device–associated intracerebral hemorrhage—a neurocritical perspective and grading
Creators: name: Prinz, Vincent
name: Manekeller, Lisa
name: Menk, Mario
name: Hecht, Nils
name: Weber-Carstens, Steffen
name: Vajkoczy, Peter
name: Finger, Tobias
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Extracorporeal membrane oxygenation
subject: ECMO
subject: Intracerebral hemorrhage
subject: Classification
subject: Surgery
subject: Outcome
subject: Coagulation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Intracerebral hemorrhage (ICH) is a devastating complication in patients treated with extracorporeal membrane oxygenation (ECMO) due to respiratory or cardiac issues. Neurosurgical evaluation and management of such cases has only insufficiently been studied. We conducted a retrospective, cohort study of adult patients treated with ECMO between January 2007 and January 2017 in a tertiary healthcare center. Demographics, clinical data, coagulation status, ICH characteristics, and treatment modalities were analyzed. The primary outcome parameter was defined as mortality caused by ICH during ECMO. 525 patients with ECMO therapy were eligible for analysis. An overall incidence for any type of intracranial bleeding of 12.3% was found. Small hemorrhages accounted for 6.4% and acute subdural and epidural hematoma for 1.2%. Twenty-four (4.6%) patients developed ICH, and 11 patients (46%) died due to the ICH. Mortality was significantly higher in patients with larger ICH volumes (86.8 +/- 34.8 ml vs 9.9 +/- 20.3 ml, p < 0.001), intraventricular hemorrhage (83% vs 8%, p = 0.01), and a fluid level inside the ICH (75% vs 31%, p = 0.04). All patients were classified according to the bleeding pattern on the initial CT scan into 3 types. Patients with type 1 bleeding were statistically more likely to die (p < 0.001). In 15 out of 24 patients (63%), correction of the coagulation status was possible within 12 h after ICH onset. Seven out of 9 patients (78%) without early coagulation correction died compared to 2 out of 15 patients (13%), in whom early coagulation correction was successful (p = 0.01). This is the first study evaluating the course and management of patients experiencing an ICH under ECMO therapy and establishing an ICH classification based on the bleeding patterns. Early correction of the coagulation is of paramount importance in the treatment of these patients.
Spinal alignment shift between supine and prone CT imaging occurs frequently and regardless of the anatomic region, risk factors, or pathology
Creators: name: Wessels, Lars
name: Komm, Bettina
name: Bohner, Georg
name: Vajkoczy, Peter
name: Hecht, Nils
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Computer-assisted spine surgery
subject: Intraoperative imaging
subject: Spinal alignment shift
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Computer-assisted spine surgery based on preoperative CT imaging may be hampered by sagittal alignment shifts due to an intraoperative switch from supine to prone. In the present study, we systematically analyzed the occurrence and pattern of sagittal spinal alignment shift between corresponding preoperative (supine) and intraoperative (prone) CT imaging in patients that underwent navigated posterior instrumentation between 2014 and 2017. Sagittal alignment across the levels of instrumentation was determined according to the C2 fracture gap (C2-F) and C2 translation (C2-T) in odontoid type 2 fractures, next to the modified Cobb angle (CA), plumbline (PL), and translation (T) in subaxial pathologies. One-hundred and twenty-one patients (C1/C2: n = 17; C3-S1: n = 104) with degenerative (39/121; 32%), oncologic (35/121; 29%), traumatic (34/121; 28%), or infectious (13/121; 11%) pathologies were identified. In the subaxial spine, significant shift occurred in 104/104 (100%) cases (CA: *p = .044; T: *p = .021) compared to only 10/17 (59%) cases that exhibited shift at the C1/C2 level (C2-F: **p = .002; C2-T: *p < .016). The degree of shift was not affected by the anatomic region or pathology but significantly greater in cases with an instrumentation length > 5 segments (" increment PL > 5 segments": 4.5 +/- 1.8 mm; " increment PL <= 5 segments": 2 +/- 0.6 mm; *p = .013) or in revision surgery with pre-existing instrumentation (" increment PL presence": 5 +/- 2.6 mm; " increment PL absence": 2.4 +/- 0.7 mm; **p = .007). Interestingly, typical morphological instability risk factors did not influence the degree of shift. In conclusion, intraoperative spinal alignment shift due to a change in patient position should be considered as a cause for inaccuracy during computer-assisted spine surgery and when correcting spinal alignment according to parameters that were planned in other patient positions.
Top 10 checkpoints with the lowest losses of Hyperbolic Softmax loss trained on MS1MV2 using parameters $\alpha=0.8, m=0.05$
Creators: name: Anonymous Author(S)
Publisher: name: Zenodo
Year: 2022

description: Top 10 checkpoints with the lowest losses of Hyperbolic Softmax loss trained on MS1MV2 using parameters $\alpha=0.8, m=0.05$
Bone morphogenetic protein 2-induced cellular chemotaxis drives tissue patterning during critical-sized bone defect healing: an in silico study
Creators: name: Borgiani, Edoardo
name: Duda, Georg N.
name: Willie, Bettina M.
name: Checa, Sara
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Bone defect healing
subject: Finite element analysis
subject: Agent-based model
subject: Mechanobiology
subject: Bone morphogenetic protein 2
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Critical-sized bone defects are critical healing conditions that, if left untreated, often lead to non-unions. To reduce the risk, critical-sized bone defects are often treated with recombinant human BMP-2. Although enhanced bone tissue formation is observed when BMP-2 is administered locally to the defect, spatial and temporal distribution of callus tissue often differs from that found during regular bone healing or in defects treated differently. How this altered tissue patterning due to BMP-2 treatment is linked to mechano-biological principles at the cellular scale remains largely unknown. In this study, the mechano-biological regulation of BMP-2-treated critical-sized bone defect healing was investigated using a multiphysics multiscale in silico approach. Finite element and agent-based modeling techniques were combined to simulate healing within a critical-sized bone defect (5 mm) in a rat femur. Computer model predictions were compared to in vivo microCT data outcome of bone tissue patterning at 2, 4, and 6 weeks postoperation. In vivo, BMP-2 treatment led to complete healing through periosteal bone bridging already after 2 weeks postoperation. Computer model simulations showed that the BMP-2 specific tissue patterning can be explained by the migration of mesenchymal stromal cells to regions with a specific concentration of BMP-2 (chemotaxis). This study shows how computational modeling can help us to further understand the mechanisms behind treatment effects on compromised healing conditions as well as to optimize future treatment strategies.
Supplementary document for Label-free Integrated Microfluidic Plasmonic Biosensor from Vertical Cavity Surface-Emitting Lasers for SARS-CoV-2 Receptor Binding Domain Protein Detection - 6316377.pdf
Creators: name: jiang, wenhui
name: Ma, Zhengtai
name: cao, fang
name: Hu, Liangchen
name: bao, lei
name: Chang, Pengying
name: Xu, Chen
name: lv, xiaoqing
name: Xie, Yiyang
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Revised Supplemental Document
title: Letter: C. Harrison Mann, Jr. to Dr. Blackwell Smith, January 3, 1964
Creators: name: Mann, Charles Harrison, Jr., 1908-1977
Publisher: name: George Mason University
Year: 2007
Subjects: subject: Mental institutions
subject: Medical College of Virginia

description: Letter: 2 pgs, typescript unsigned, 11" x 8.5" (27.9 cm x 21.6 cm)
description: Annotated letter from C. Harrison Mann, Jr. to Dr. Blackwell Smith, Medical College of Virginia, regarding the lack of medical scholarships aimed at producing doctors to work in mental institutions. C. Harrison Mann, Jr. Collection 21.11
title: Phazelia :
title: Principes directeurs pour la conduite de l’examen de la distinction, de l’homogénéité et de la stabilité.
titleType: Subtitle
Creators: name: International Union For The Protection Of New Varieties Of Plants,
Publisher: name: International Union for the Protection of New Varieties of Plants,
Year: 0
Subjects: Plants
New Varieties of Plants
Scorpion Weed
California Bluebell

description: Ces principes directeurs (“principes directeurs d’examen”) visent à approfondir les principes énoncés dans l’introduction générale (document TG/1/3) et dans les documents TGP qui s’y rapportent afin de donner des indications concrètes détaillées pour l’harmonisation de l’examen de la distinction, de l’homogénéité et de la stabilité (DHS) et, en particulier, à identifier des caractères convenant à l’examen DHS et à la production de descriptions variétales harmonisées.
title: Acoustic modeshape inversion using deep water ambient noise measurements
Creators: name: AlMuhanna, Khalid A.
Publisher: name: George Mason University
Year: 2008
Subjects: subject: Modes
subject: Underwater
subject: Noise
subject: Ambient
subject: Ocean
subject: Acoustics

description: Ocean acoustic tomography is a powerful method that uses sound to study ocean properties such as temperature, which is directly related to sound speed in water. This thesis focuses on using ambient noise to infer the normal modes of the ocean waveguide. The modes are a set of orthogonal functions that are solutions to the depth dependent wave equation, which depends on sound speed and thus on the temperature. Assuming that noise signals received by a vertical array consist of a sum of uncorrelated modes, the modeshapes can be determined from an eigenvector decomposition of the measured cross-spectral density matrix. Several authors have applied this technique to estimate the modes of shallow water waveguides, but there have been few opportunities to apply this technique in deep water waveguides. In this thesis the modeshapes of a deep water environment in the North Pacific are estimated using ambient noise data measured during the SPICE04 experiment. Although noise measurements were not the primary focus of SPICE04, the experiment provided a large data set for this analysis. In addition to acoustic measurements, the experiment also included extensive sampling of the environmental parameters. This thesis summarizes some of the noise statistics measured during 2004-2005. The measured modeshapes derived from the data are compared with the true modes derived from the measured environmental data.
Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells
Creators: name: Lehmann, Malte
name: Allers, Kristina
name: Heldt, Claudia
name: Meinhardt, Jenny
name: Schmidt, Franziska
name: Rodriguez-Sillke, Yasmina
name: Kunkel, Désirée
name: Schumann, Michael
name: Böttcher, Chotima
name: Stahl-Hennig, Christiane
name: Elezkurtaj, Sefer
name: Bojarski, Christian
name: Radbruch, Helena
name: Corman, Victor M.
name: Schneider, Thomas
name: Loddenkemper, Christoph
name: Moos, Verena
name: Weidinger, Carl
name: Kühl, Anja A.
name: Siegmund, Britta
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: SARS-CoV-2
subject: CD8+ T cells
subject: Mucosal infiltration
subject: Human small intestinal
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The SARS-CoV-2 pandemic has so far claimed over three and a half million lives worldwide. Though the SARS-CoV-2 mediated disease COVID-19 has first been characterized by an infection of the upper airways and the lung, recent evidence suggests a complex disease including gastrointestinal symptoms. Even if a direct viral tropism of intestinal cells has recently been demonstrated, it remains unclear, whether gastrointestinal symptoms are caused by direct infection of the gastrointestinal tract by SARS-CoV-2 or whether they are a consequence of a systemic immune activation and subsequent modulation of the mucosal immune system. To better understand the cause of intestinal symptoms we analyzed biopsies of the small intestine from SARS-CoV-2 infected individuals. Applying qRT-PCR and immunohistochemistry, we detected SARS-CoV-2 RNA and nucleocapsid protein in duodenal mucosa. In addition, applying imaging mass cytometry and immunohistochemistry, we identified histomorphological changes of the epithelium, which were characterized by an accumulation of activated intraepithelial CD8(+) T cells as well as epithelial apoptosis and subsequent regenerative proliferation in the small intestine of COVID-19 patients. In summary, our findings indicate that intraepithelial CD8(+) T cells are activated upon infection of intestinal epithelial cells with SARS-CoV-2, providing one possible explanation for gastrointestinal symptoms associated with COVID-19.
Initial mechanical conditions within an optimized bone scaffold do not ensure bone regeneration – an in silico analysis
Creators: name: Perier-Metz, Camille
name: Duda, Georg N.
name: Checa, Sara
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Bone scaffold
subject: Bone regeneration
subject: Scaffold design optimization
subject: Computational mechano-biology
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Large bone defects remain a clinical challenge because they do not heal spontaneously. 3-D printed scaffolds are a promising treatment option for such critical defects. Recent scaffold design strategies have made use of computer modelling techniques to optimize scaffold design. In particular, scaffold geometries have been optimized to avoid mechanical failure and recently also to provide a distinct mechanical stimulation to cells within the scaffold pores. This way, mechanical strain levels are optimized to favour the bone tissue formation. However, bone regeneration is a highly dynamic process where the mechanical conditions immediately after surgery might not ensure optimal regeneration throughout healing. Here, we investigated in silico whether scaffolds presenting optimal mechanical conditions for bone regeneration immediately after surgery also present an optimal design for the full regeneration process. A computer framework, combining an automatic parametric scaffold design generation with a mechano-biological bone regeneration model, was developed to predict the level of regenerated bone volume for a large range of scaffold designs and to compare it with the scaffold pore volume fraction under favourable mechanical stimuli immediately after surgery. We found that many scaffold designs could be considered as highly beneficial for bone healing immediately after surgery; however, most of them did not show optimal bone formation in later regenerative phases. This study allowed to gain a more thorough understanding of the effect of scaffold geometry changes on bone regeneration and how to maximize regenerated bone volume in the long term.
Influence of Patient-Specific Covariates on Test Validity of Two Delirium Screening Instruments in Neurocritical Care Patients (DEMON-ICU)
Creators: name: Weiss, Björn
name: Paul, Nicolas
name: Spies, Claudia D.
name: Ullrich, Dennis
name: Ansorge, Ingrid
name: Salih, Farid
name: Wolf, Stefan
name: Luetz, Alawi
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: CAM-ICU
subject: Critical care
subject: Delirium
subject: Hypnotics and sedatives
subject: ICDSC
subject: Neurocritical care
subject: Sensitivity
subject: Specificity
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Delirium screening instruments (DSIs) should be used to detect delirium, but they only show moderate sensitivity in patients with neurocritical illness. We explored whether, for these patients, DSI validity is impacted by patient-specific covariates. Methods: Data were prospectively collected in a single-center quality improvement project. Patients were screened for delirium once daily using the Intensive Care Delirium Screening Checklist (ICDSC) and the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Reference was the daily assessment using criteria from the Diagnostic and Statistical Manual, 4th Edition, Text Revision (DSM-IV-TR). In a two-step receiver operating characteristics regression analysis adjusting for repeated measurements, the impact of acute diagnosis of stroke or transient ischemic attack (TIA), neurosurgical intervention, Richmond Agitation Sedation Scale, and ventilation status on test validity was determined. Results: Of 181 patients screened, 101 went into final analysis. Delirium incidence according to DSM-IV-TR was 29.7%. For the first complete assessment series (CAM-ICU, ICDSC, and DSM-IV-TR), sensitivity for the CAM-ICU and the ICDSC was 73.3% and 66.7%, and specificity was 91.8% and 94.1%, respectively. Consideration of daily repeated measurements increased sensitivity for the CAM-ICU and ICDSC to 75.7% and 73.4%, and specificity to 97.3% and 98.9%, respectively. Receiver operating characteristics regression revealed that lower Richmond Agitation Sedation Scale levels significantly impaired validity of the ICDSC (p = 0.029) and the CAM-ICU in its severity scale version (p = 0.004). Neither acute diagnosis of stroke or TIA nor neurosurgical intervention or mechanical ventilation significantly influenced DSI validity. Conclusions: The CAM-ICU and ICDSC perform well in patients requiring neurocritical care, regardless of the presence of acute stroke, TIA, or neurosurgical interventions. Yet, even very light or moderate sedation can significantly impair DSI performance.
Attentional bias in individuals with depression and adverse childhood experiences: influence of the noradrenergic system?
Creators: name: Kuehl, Linn K.
name: Deuter, Christian E.
name: Nowacki, Jan
name: Ueberrueck, Lisa
name: Wingenfeld, Katja
name: Otte, Christian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Alpha2-adrenergic receptor
subject: Childhood trauma
subject: Dot probe
subject: Major depressive disorder
subject: Norepinephrine
subject: Yohimbine
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Rationale: Major depressive disorder (MDD) is a severe mental disorder with affective, cognitive, and somatic symptoms. Mood congruent cognitive biases, including a negative attentional bias, are important for development, maintenance, and recurrence of depressive symptoms. MDD is associated with maladaptive changes in the biological stress systems such as dysregulations of central noradrenergic alpha2-receptors in the locus coeruleus-noradrenergic system, which can affect cognitive processes including attention. Patients with adverse childhood experiences (ACE), representing severe stress experiences in early life, might be particularly affected. Objectives: With an experimental design, we aimed to gain further knowledge about the role of noradrenergic activity for attentional bias in MDD patients with and without ACE. Methods: We tested the effect of increased noradrenergic activity induced by the alpha2-receptor blocker yohimbine on attentional bias in a placebo-controlled repeated measures design. Four groups were included as follows: MDD patients with and without ACE, and healthy participants with and without ACE (total N = 128, all without antidepressant medication). Results: A significant effect of MDD on attentional bias scores of sad face pictures (p = .037) indicated a facilitated attentional processing of sad face pictures in MDD patients (compared to non-MDD individuals). However, we found no such effect of ACE. For attentional bias of happy face pictures, we found no significant effects of MDD and ACE. Even though a higher increase of blood pressure and salivary alpha-amylase following yohimbine compared to placebo indicated successful noradrenergic stimulation, we found no significant effects of yohimbine on attentional bias of happy or sad face pictures. Conclusions: Our results are consistent with the hypothesis of a negative attentional bias in MDD patients. However, as we found no effect of ACE or yohimbine, further research is needed to understand the mechanisms by which ACE increases the risk of MDD and to understand the biological basis of the MDD-related negative attentional bias.
The Genetic Basis of Moyamoya Disease
Creators: name: Mertens, Robert
name: Graupera, M.
name: Gerhardt, Holger
name: Bersano, A.
name: Tournier-Lasserve, E.
name: Mensah, Martin Atta
name: Mundlos, Stefan
name: Vajkoczy, Peter
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Moyamoya disease
subject: Genetics
subject: FOS: Biological sciences
subject: RNF 213
subject: 17q25
subject: Stroke
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Moyamoya disease (MMD) is a rare cerebrovascular disease characterized by progressive spontaneous bilateral occlusion of the intracranial internal cerebral arteries (ICA) and their major branches with compensatory capillary collaterals resembling a "puff of smoke" (Japanese: Moyamoya) on cerebral angiography. These pathological alterations of the vessels are called Moyamoya arteriopathy or vasculopathy and a further distinction is made between primary and secondary MMD. Clinical presentation depends on age and population, with hemorrhage and ischemic infarcts in particular leading to severe neurological dysfunction or even death. Although the diagnostic suspicion can be posed by MRA or CTA, cerebral angiography is mandatory for diagnostic confirmation. Since no therapy to limit the stenotic lesions or the development of a collateral network is available, the only treatment established so far is surgical revascularization. The pathophysiology still remains unknown. Due to the early age of onset, familial cases and the variable incidence rate between different ethnic groups, the focus was put on genetic aspects early on. Several genetic risk loci as well as individual risk genes have been reported; however, few of them could be replicated in independent series. Linkage studies revealed linkage to the 17q25 locus. Multiple studies on the association of SNPs and MMD have been conducted, mainly focussing on the endothelium, smooth muscle cells, cytokines and growth factors. A variant of the RNF213 gene was shown to be strongly associated with MMD with a founder effect in the East Asian population. Although it is unknown how mutations in the RNF213 gene, encoding for a ubiquitously expressed 591 kDa cytosolic protein, lead to clinical features of MMD, RNF213 has been confirmed as a susceptibility gene in several studies with a gene dosage-dependent clinical phenotype, allowing preventive screening and possibly the development of new therapeutic approaches. This review focuses on the genetic basis of primary MMD only.
title: Porgy and Bess
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 1997
Subjects: subject: Porgy and Bess
subject: Everyman Opera
subject: Gershwin, George
subject: Colbert, Helen
subject: Heyward, DuBose
subject: Gershwin, Ira
subject: Breen, Robert
subject: Smallens, Alexander
subject: Roth, Wolfgang
subject: Mace, Jed

description: Theater review.
[Donation records]
[籌捐胡德案花紅銀緣部]
Creators: name: Chock On Fong
Publisher: name: The University of British Columbia
Year: 2011

description: Donation records created by Hu Jin. Within the records there are letters and a list of donors. The letters included are Chock On Fong's 1939 letter to the brotherhood and a letter written in 1946 from Hu Jin to Hu Shiyi and Hu Shiduo. The donation was collected for Hu De who was murdered.
Black Hole Mergers as Rebalancing of Orbital Superstructures
Creators: name: Passolungo, Simone
Publisher: name: Zenodo
Year: 2025

description: This document explores the merger of two black holes as a coherent manifestation of energy delta rebalancing, in accordance with the theory of bound orbital structures. Black holes can be considered high-coherence orbital superstructures, and their interaction is a gravitational dissipative phenomenon culminating in the formation of a more stable structure.
title: Letter: C. Harrison Mann, Jr. to Harry F. Byrd, January 30, 1963
Creators: name: Mann, Charles Harrison, Jr., 1908-1977
Publisher: name: George Mason University
Year: 2005
Subjects: subject: Taxes

description: Letter A: typescript unsigned, 11" x 8.5" (29.7 cm x 21.6 cm)
description: Letter from C. Harrison Mann, Jr. to Harry F. Byrd, senator from Virginia, regarding President John F. Kennedy's proposed tax cut program. Mann is opposing the proposed program. C. Harrison Mann, Jr. Collection 2.08
Initiation of therapy for obstructive sleep apnea syndrome: a randomized comparison of outcomes of telemetry-supported home-based vs. sleep lab-based therapy initiation
Creators: name: Fietze, Ingo
name: Herberger, Sebastian
name: Wewer, Gina
name: Woehrle, Holger
name: Lederer, Katharina
name: Lips, Aline
name: Willes, Leslee
name: Penzel, Thomas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Obstructive sleep apnea
subject: Automatic positive airway pressure
subject: Continuous positive airway pressure
subject: Compliance
subject: Adherence
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Diagnosis and treatment of obstructive sleep apnea are traditionally performed in sleep laboratories with polysomnography (PSG) and are associated with significant waiting times for patients and high cost. We investigated if initiation of auto-titrating CPAP (APAP) treatment at home in patients with obstructive sleep apnea (OSA) and subsequent telemonitoring by a homecare provider would be non-inferior to in-lab management with diagnostic PSG, subsequent in-lab APAP initiation, and standard follow-up regarding compliance and disease-specific quality of life. Methods: This randomized, open-label, single-center study was conducted in Germany. Screening occurred between December 2013 and November 2015. Eligible patients with moderate-to-severe OSA documented by polygraphy (PG) were randomized to home management or standard care. All patients were managed by certified sleep physicians. The home management group received APAP therapy at home, followed by telemonitoring. The control group received a diagnostic PSG, followed by therapy initiation in the sleep laboratory. The primary endpoint was therapy compliance, measured as average APAP usage after 6 months. Results: The intention-to-treat population (ITT) included 224 patients (110 home therapy, 114 controls); the per-protocol population (PP) included 182 patients with 6-month device usage data (89 home therapy, 93 controls). In the PP analysis, mean APAP usage at 6 months was not different in the home therapy and control groups (4.38 +/- 2.04 vs. 4.32 +/- 2.28, p = 0.845). The pre-specified non-inferiority margin (NIM) of 0.3 h/day was not achieved (p = 0.130); statistical significance was achieved in a post hoc analysis when NIM was set at 0.5 h/day (p < 0.05). Time to APAP initiation was significantly shorter in the home therapy group (7.6 +/- 7.2 vs. 46.1 +/- 23.8 days; p < 0.0001). Conclusion: Use of a home-based telemonitoring strategy for initiation of APAP in selected patients with OSA managed by sleep physicians is feasible, appears to be non-inferior to standard sleep laboratory procedures, and facilitates faster access to therapy.
title: Efficacy of Brilacidin against Venezuelan Equine Encephalitis Virus
Creators: name: Smith, Miata
Publisher: name: George Mason University
Year: 2023
Subjects: subject: Brilacidin
subject: Venezuelan
subject: Encephalitis
subject: Alphavirus

description: This thesis has been embargoed for 2 years. It will not be available until May 2023 at the earliest.
description: Venezuelan Equine Encephalitis Virus (VEEV) is a positive-sense, single-stranded, enveloped-RNA alphavirus of the Togaviridae family that is transmitted through the bite of an Aedes aegypti and Aedes albopictus mosquito species. There are no vaccines or therapeutic treatments available for VEEV, which exacerbates the need for better therapeutics. It is important to have therapeutics available that can inhibit viral replication and decrease the viral load early to stop the progression of neurological illness or damage and lessen the severity of other associated symptoms. Brilacidin is a potential antiviral drug that can be used to inhibit VEEV infection given its mechanistic ability to interfere with viral replication at the cell membrane. The efficacy of Brilacidin in VEEV will be evaluated through a series of experiments that will explore the dynamic of inhibition, safe testing concentrations, and its peak window of efficacy to gain a better understanding of the mechanistic impact on the host cell’s phospholipid bilayer in cell culture.
title: Modeling the Effects of Dehydration on Cellular Growth and Wound Repair
Creators: name: Dando, Emma
Publisher: name: George Mason University
Year: 2021
Subjects: subject: Dehydration
subject: Modeling

description: Dehydration is a common problem among athletes and the elderly, both of whom get injured more frequently than the average adult. Dehydration has been linked to reduced circulation, a reduced amount of water being absorbed into the cellular matrix, increased inflammation, decreased blood pressure, decreased volume of plasma, increased heart rate, decreased cellular density, and increase adhesion constant, depending on the severity and duration of dehydration. A comprehensive and functioning model describing the impacts of dehydration on tissue growth could be used when studying and designing treatment plans for groups vulnerable to dehydration and to inform decisions on environments for growing cell cultures and tissue in vitro. Previous models have described hydration and water replacement in the human body or the process of tissue growth or wound repair. This model integrates the effects of dehydration with the parameters of wound repair to create a more comprehensive model. This resulting model is a combination and modification of a continuum and a partial differential equation model. The continuum model is modified to consider more of the effects of dehydration on the tissue with the intent to increase the accuracy of the model. The overlapping parameters and relationships are used to link the models together. The combined model is then modified with unitless parameters that represent the severity and duration of dehydration to create the final model. The model found that while the simulated subject is fully hydrated, intralayer elastic couplings are the largest factor that increases cell density, being to a power of nine. The influence of the tangential diffusion of cells is only to a power of one and comparatively uninfluential. The grouped effect of cell crowding and cell synthesis and apoptosis to decrease cellular density is to a power of negative nine, so mathematically it balances out the effect of the elastic couplings. The influence of the tangential velocity of cells is the next most influential component to decrease the cellular density, at a power of five. During severe dehydration, the cell crowding component and the elastic component changed by a power of four, the cell crowding component becoming less negative and the elastic couplings component increasing. Both the tangential diffusion and tangential velocity decreased by a power of two. Unexpectedly, the cellular density changed very little with varying simulations of dehydration. Despite this, the model shows that dehydration slows the rate of wound healing and it suggests that the severity of dehydration is more detrimental than the duration of dehydration.
HIT-6 and EQ-5D-5L in patients with migraine: assessment of common latent constructs and development of a mapping algorithm
Creators: name: Oliveira Gonçalves, Ana Sofia
name: Panteli, Dimitra
name: Neeb, Lars
name: Kurth, Tobias
name: Aigner, Annette
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Mapping
subject: EQ-5D
subject: QALY
subject: Utilities
subject: HIT-6
subject: Migraine
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objective: The aims of this study were to assess whether there is a conceptual overlap between the questionnaires HIT-6 and EQ-5D and to develop a mapping algorithm allowing the conversion of HIT-6 to EQ-5D utility scores for Germany. Methods: This study used data from an ongoing randomised controlled trial for patients suffering from migraine. We assessed the conceptual overlap between the two instruments with correlation matrices and exploratory factor analysis. Linear regression, tobit, mixture, and two-part models were used for mapping, accounting for repeated measurements, tenfold cross-validation was conducted to validate the models. Results: We included 1010 observations from 410 patients. The EQ-5D showed a substantial ceiling effect (47.3% had the highest score) but no floor effect, while the HIT-6 showed a very small ceiling effect (0.5%). The correlation between the instruments' total scores was moderate (- 0.30), and low to moderate among each domain (0.021-0.227). The exploratory factor analysis showed insufficient conceptual overlap between the instruments, as they load on different factors. Thus, there is reason to believe that the instruments' domains do not capture the same latent constructs. To facilitate future mapping, we provide coefficients and a variance-covariance matrix for the preferred model, a two-part model with the total HIT-6 score as the explanatory variable. Conclusion: This study showed that the German EQ-5D and the HIT-6 lack the conceptual overlap needed for appropriate mapping. Thus, the estimated mapping algorithms should only be used as a last resort for estimating utilities to be employed in economic evaluations.
Il Diritto: così la Musica, così la Vita
Creators: name: Orciani, Luca
Publisher: name: Università degli Studi di Urbino "Carlo Bo"
Year: 2016

description: [Law like Music and Life] Luca Orciani reviews the recent book Interpretare. Dialogo tra un musicista e un giurista by Mario Brunello and Gustavo Zagrebelsky (Bologna, il Mulino, 2016). Through a very close dialogue, Authors move across two worlds, two performative disciplines, two passions. With a critical sensitiveness, Orciani points out the important topics focused in the book (interpretation, creativity, virtuosity, perfection, but not only), asking some questions that are essential in Music as in Law.
description: Cultura giuridica e diritto vivente, Vol 3 (2016)
Luci e ombre nella disciplina delle prescrizioni amministrative dei reati ambientali
Creators: name: Zampini, Andrea
Publisher: name: Università degli Studi di Urbino "Carlo Bo"
Year: 2016

description: [Lights and shadows in the regulation of administrative prescriptions of environmental crimes] The Law no. 68/2015 made several amendments to the italian environmental penal regulation. This paper analyzes the new Part Six bis of the legislative decree no. 152/2006, which contains the mechanism of administrative prescriptions intended to "repair" the consequences of the contraventions contained in the decree. At the same time, the new regulation creates a special cause of extinguishment of offence for those who accomplishes the mentioned administrative prescriptions. Moreover, in this work are examined the questions of compliance of this legal regulation with the Constitution, even through some court case.
description: Cultura giuridica e diritto vivente, Vol 3 (2016)
Total body irradiation as part of conditioning regimens in childhood leukemia—long-term outcome, toxicity, and secondary malignancies
Creators: name: Gruen, Arne
name: Exner, Sebastian
name: Kühl, Jörn-Sven
name: Stackelberg, Arend Von
name: Budach, Volker
name: Stromberger, Carmen
name: Boehmer, Dirk
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Survival
subject: Late adverse events
subject: Radiation induced cancer
subject: Pediatric
subject: Cancer of the blood
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Total body irradiation (TBI) is an established part of conditioning regimens prior to stem cell transplantation in childhood leukemia but is associated with long-term toxicity. We retrospectively analyzed survival, long-term toxicity, and secondary malignancies in a pooled cohort of pediatric patients (pts.) treated with the same TBI regimen. Methods: Analyzed were 109 pts. treated between September 1996 and November 2015. Conditioning treatment according to EBMT guidelines and the ALL SCTped 2012 FORUM trial consisted of chemotherapy (CT) and TBI with 2 Gy b.i.d. on 3 consecutive days to a total dose of 12 Gy. Median follow-up was 97.9 months (2-228 months). Results: Overall survival (OS) in our cohort at 2, 5, and 10 years was 86.1, 75.5, and 63.0%, respectively. Median survival was not reached. Long-term toxicity developed in 47 pts. After chronically abnormal liver and kidney parameters in 31 and 7 pts., respectively, growth retardation was the most frequent finding as seen in 13 pts. Secondary malignancies were rare (n = 3). Conclusion: TBI-containing conditioning regimens in pediatric stem cell transplantation (SCT) are highly effective. Efforts to replace TBI- with CT-containing regimens have only been successful in subgroups of pts. Although we could show long-term toxicity in 43% of pts., overall survival was 63% at 10 years. Still, long-term effects such as growth retardation can permanently impact the pts.' quality of life and functioning. Along with new substances, efforts should be undertaken to optimize TBI techniques and accompany the treatment by systematic follow-up programs beyond 5 years to improve detection of rare events.
Challenges of single-stage pancreatoduodenectomy: how to address pancreatogastrostomies with robotic-assisted surgery
Creators: name: Timmermann, Lea
name: Hillebrandt, Karl Herbert
name: Felsenstein, Matthäus
name: Schmelzle, Moritz
name: Pratschke, Johann
name: Malinka, Thomas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Pancreatogastrostomy
subject: Pancreato-enteric anastomosis
subject: Pancreatoduodenectomy
subject: Robotic-assisted
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction: Establishing a sufficient pancreatico-enteric anastomosis remains one of the most important challenges in open single stage pancreatoduodenectomy as they are associated with persisting morbidity and mortality. Applicability on a robotic-assisted approach, however, even increases the requirements. With this analysis we introduce a dorsal-incision-only invagination type pancreatogastrostomy (dioPG) to the field of robotic assistance having been previously proven feasible in the field of open pancreatoduodenectomy and compare initial results to the open approach by means of morbidity and mortality. Methods: An overall of 142 consecutive patients undergoing reconstruction via the novel dioPG, 38 of them in a robotic-assisted and 104 in an open approach, was identified and further reviewed for perioperative parameters, complications and mortality. Results: We observed a comparable R0-resection rate (p = 0.448), overall complication rate (p = 0.52) and 30-day mortality (p = 0.71) in both groups. Rates of common complications, such as postoperative pancreatic fistula (p = 0.332), postoperative pancreatic hemorrhage (p = 0.242), insufficiency of pancreatogastrostomy (p = 0.103), insufficiency of hepaticojejunostomy (p = 0.445) and the re-operation rate (p = 0.103) were comparable. The procedure time for the open approach was significantly shorter compared to the robotic-assisted approach (p = 0.024). Discussion: The provided anastomosis appeared applicable to a robotic-assisted setting resulting in comparable complication and mortality rates when compared to an open approach. Nevertheless, also in the field of robotic assistance establishing a predictable pancreatico-enteric anastomosis remains the most challenging aspect of modern single-stage pancreatoduodenectomy and requires expertise and experience.
Appreciation and job control predict depressive symptoms: results from the Study on Mental Health at Work
Creators: name: Pohrt, Anne
name: Fodor, Daniel
name: Burr, Hermann
name: Kendel, Friederike
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Depressive symptom
subject: PHQ-9
subject: S-MGA study
subject: Working conditions
subject: Job control
subject: Critical life events
subject: Caregivers
subject: Appreciation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objective: Depressive symptoms are a leading cause of disability retirement and sick leave. The aim of this study was to assess the risk of depressive symptoms in German employees and its associations with factors from both the occupational and the non-occupational domain and gender. Methods: In the second wave of the German Study of Mental Health at Work (SMGA), a representative sample of 2640 German employees (52% women) was studied. Depressive symptoms were assessed with the PHQ-9 questionnaire. Psychosocial occupational and non-occupational conditions were assessed with quantitative interviews. In this cross-sectional sample, the association of these factors with depressive symptoms was examined using logistic regression models. Results: Factors from both the occupational and the non-occupational domain were associated with risk of depressive symptoms. Low appreciation from superior (ORmen 2.1 (95% CI 1.2-3.7); ORwomen 3.2 (95% CI 2.1-4.8)), low job control (ORmen 2.9 (95% CI 1.6-5.4); ORwomen 1.6 (95% CI 1.0-2.5)), and critical life events (ORmen 3.0 (95% CI 1.6-5.4); ORwomen 2.3 (95% CI 1.5-3.7)) had the strongest association with risk of depressive symptoms. The association with quantitative demands was stronger in caregivers than in non-caregivers. The results indicated possible differences in the associations of working conditions between men and women, and between family caregivers and non-caregivers. Conclusion: Factors from both work and private life are associated with depressive symptoms, especially appreciation, job control, and critical life events. Gender differences, with respect to appreciation and influence at work, suggest a more gender sensitive approach to psychosocial occupational health research and interventions.
title: Narrative Analysis of Film Music: Rota's Score to Under Ten Flags
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2019

description: This dissertation describes the current state of analysis of film music with the intent of finding connections between ideas on narrative analysis and film music. I posit an approach from Almén that overlays Micznik’s semiotic and discursive categories onto Liska’s three analytical levels and applies the analysis to cues of Nino Rota’s score for Under Ten Flags. The result is an analysis of a film score that considers the intrinsic degree of narrativity apart from a vococentric film perspective. Through this analysis I intend to demonstrate the narrative potential of a film score realized through a taking stock of its structural and semantic elements. The technique I am proposing could be used in other film projects to synthesize filmic diegesis with a score’s narrative trajectory. Understanding a film score’s intrinsic meaning can also be useful in developing an approach to film music appreciation that has not been addressed yet in publication.