title: ÐÐµÑ Ð°Ð½Ð¸Ð·Ð¼Ñ Ð½Ð°ÑÑÑÐµÐ½Ð¸Ð¹ Ð² ÑÐµÐ³ÑÐ»ÑÑÐ¸Ð¸ Ð³Ð»ÑÑÐ°Ð¼Ð°Ñ Ð¸ ÐÐÐÐ-ÐµÑÐ³Ð¸ÑÐµÑÐºÐ¸Ñ Ð½ÐµÐ¹ÑÐ¾Ð½Ð¾Ð² Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿Ð° Ð¿ÑÐ¸ ÑÐµÑÐ»ÐµÐºÑÐ¾ÑÐ½Ð¾Ð¹ Ð°ÑÐ´Ð¸Ð¾Ð³ÐµÐ½Ð½Ð¾Ð¹ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸ Ð½Ð° Ð¿Ð¾Ð·Ð´Ð½Ð¸Ñ ÑÑÐ°Ð¿Ð°Ñ Ð¾Ð½ÑÐ¾Ð³ÐµÐ½ÐµÐ·Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Mechanisms of regulation disorders of glutamate- and GABA-ergic neurons of the hippocampus in reflex audiogenic epilepsy at the late stages of ontogenesis
Creators: name: Ð£ÑÐ°ÑÑÑ, ÐÐ½Ð´ÑÐµÐ¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ñ
ÑÑÐ°ÑÐµÐ½Ð¸Ðµ
Ð»Ð¸Ð½Ð¸Ñ ÐºÑÑÑ ÐÑÑÑÐ¸Ð½ÑÐºÐ¾Ð³Ð¾-ÐÐ¾Ð»Ð¾Ð´ÐºÐ¸Ð½Ð¾Ð¹
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ÐÐÐÐ
Ð³Ð»ÑÑÐ°Ð¼Ð°Ñ
Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿
Ð½ÐµÐ¹ÑÐ¾ÑÑÐ°Ð½ÑÐ¼Ð¸ÑÑÐ¸Ñ
Ð½ÐµÐ¹ÑÐ¾Ð¼ÐµÐ´Ð¸Ð°ÑÐ¾ÑÑ
epilepsy
aging
Krushinsky-Molodkina rat strain
Wistar rat strain
GABA
glutamate
hippocampus
neurotransmission
neurotransmitters

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description: The given work is devoted to analysis of functional and structural changes in the dorsal hippocampus of old intact Krushinsky-Molodkina (KM) rats prone to audiogenic reflex epilepsy in comparison with healthy old Wistar rats and in comparison with young KM rats. A comprehensive analysis of markers of dorsal hippocampal neuronal activity by immunohistochemistry, Western blot and real-time PCR was performed.Â  A significant increase in the content of cell activity factors in both glutamate and GABA-ergic neurons in the hippocampus of old KM rats was shown in comparison with old Wistar rats. These data indicate the importance of genetic abnormalities that are specific to audiogenic reflex epilepsy in the occurrence of disorders in the hippocampus during aging. Increased cell death in the dentate gyrus of the hippocampus was found in old KM rats compared to old Wistar rats. A reduced content of cell activation marker proteins in GABAergic neurons of the hippocampus was shown in naive 18 month old KM rats compared to young KM rats, indicating a contribution of age-related changes in the development of pathological states associated with reflex epilepsy. It can be concluded that epilepsy enhance neurodegenerative changes that occur in the brain with aging, such as neuronal death and disruption of the normal functioning of glutamate- and GABA-ergic neurons.