cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Protocol for the development of a core domain set for individuals with ankle osteoarthritis
Creators: name: Alanazi, SA
name: Vicenzino, B
name: van Bergen, CJA
name: Hunter, DJ
name: Wikstrom, EA
name: Menz, Hylton
name: Golightly, YM
name: Smith, MD
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3202
subject: Clinical sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 4202
subject: Epidemiology

description: Background: Ankle osteoarthritis (OA) is a debilitating health condition that is increasing in prevalence. Currently, there are no evidence-based guidelines for managing ankle OA. One of the current challenges to establishing guidelines is the lack of a widely agreed-upon set of outcome measures that are consistently used in ankle OA research. Without a set of agreed-upon outcome measures, it is difficult to synthesise clinical trial outcomes through meta-analysis—an essential element of evidence-informed practice. In order to develop an appropriate set of outcome measures for ankle OA, it is important first to develop a core domain set. In this protocol, we describe the methodological approach that we will use to develop such a core domain set for ankle OA. Methods: We established an international steering committee to guide the development of a core domain set for ankle OA. The core domain set development will follow a multi-staged approach consisting of three phases, involving participation by patients and clinicians/healthcare professionals. In phase 1, a list of candidate domains will be gleaned from (a) a scoping review of outcome measures used in ankle OA research, (b) qualitative interviews with individuals with ankle OA, and (c) qualitative interviews with healthcare professionals with expertise in ankle OA. In phase 2, the steering committee will review and generate a list of candidate domains from those gleaned in phase 1. In phase 3, this list of candidate domains will be considered in a Delphi process to reach a consensus on a core domain set. We anticipated this will involve 3 rounds of surveys. Conclusion: This protocol describes the methods that will be used to develop a core domain set of health-related aspects for ankle OA. Importantly, it will include both healthcare professional and patient involvement. This is a prerequisite step to developing a core outcome set for ankle OA that should be reported in all clinical trials for ankle OA. The findings will be widely disseminated across peer-refereed publication(s) and national and international conferences, as well as via relevant professional societies, patient support group organisations, and social media platforms.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VI, Cart. 190 (11 H 75), 316 folios, f. 0152r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VI, Archives départementales de la Côte-d'Or, Cart. 190 (11 H 75), 316 folios, f. 0152r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VI, Archives départementales de la Côte-d'Or, Cart. 190 (11 H 75), 316 folios, f. 0152r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Using photovoice to explore women's experiences of a women-only prevention and recovery care service in Australia
Creators: name: Dixon, K
name: Fossey, Ellie
name: Petrakis, M
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 4409
subject: Social work
classificationCode: 4203
subject: Health services and systems
classificationCode: 4206
subject: Public health

description: Women should be able to access mental health services that are safe, free from harassment and abuse. Yet, research indicates that women experiencing mental health issues are often not safe in mixed gender environments, and especially in inpatient settings. This qualitative study draws on a photo-elicitation method (‘photovoice’) and semi-structured interviews to explore women's experiences of a sub-acute women-only prevention and recovery care (PARC) service in Australia. Twelve women experiencing mental health issues were recruited via an aftercare peer support group for recent service participants. The women took photographs guided by the central question: ‘What were your experiences of a women-only prevention and recovery care service?’ They then shared these photographs with the researchers and each other, and described them in detail. Four key themes were identified by thematic analysis of the photovoice visual and narrative data: (a) Only women can understand what women go through; (b) I feel safer with no men around due to my history of trauma; (c) This environment feels safe, making it easier to talk and (d) Staff are accessible and make time for me to talk about difficult topics. Woven throughout the women's narratives was the expressed desire to feel safe and supported during the process of recovering. Aspects of service delivery that contributed to these feelings and facilitated shared support were also valued in this setting. These findings indicate that access to women-only services and peer support are not only valued by women experiencing mental health issues, but need to be more widely available to support their recovery. They also underline the importance of a trauma-informed approach for improving the gender sensitivity of services.
Supplementary materials: Figs S1 - S6, methods and supplementary table from Multiple interactions are involved in a highly specific association of the Mod(mdg4)-67.2 isoform with the Su(Hw) sites in Drosophila
Creators: name: Melnikova, Larisa
name: Kostyuchenko, Margarita
name: Molodina, Varvara
name: Parshikov, Alexander
name: Georgiev, Pavel
name: Golovnin, Anton
Publisher: name: The Royal Society
Year: 2017
Subjects: Molecular Biology

description: This file contains Supplementary Figures, material and methods, and primer sequences used in PCR for ChIP analysis.
Policy-Relevant Spatial Inidicators of Urban Liveability And Sustainability: Scaling From Local to Global
Creators: name: Higgs, C
name: Alderton, A
name: Rozek, J
name: Adlakha, D
name: Badland, H
name: Boeing, G
name: Both, A
name: Cerin, E
name: Chandrabose, M
name: De Gruyter, C
name: De Livera, Alysha
name: Gunn, L
name: Hinckson, E
name: Liu, S
name: Mavoa, S
name: Sallis, JF
name: Simons, K
name: Giles-Corti, B
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 4407
subject: Policy and administration
classificationCode: 3304
subject: Urban and regional planning
classificationCode: 4406
subject: Human geography

description: Urban liveability is a global priority for creating healthy, sustainable cities. Measurement of policy-relevant spatial indicators of the built and natural environment supports city planning at all levels of government. Analysis of their spatial distribution within cities, and impacts on individuals and communities, is crucial to ensure planning decisions are effective and equitable. This paper outlines challenges and lessons from a 5-year collaborative research program, scaling up a software workflow for calculating a composite indicator of urban liveability for residential address points across Melbourne, to Australia’s 21 largest cities, and further extension to 25 global cities in diverse contexts.
Widening Access and Managing Recruitment with Smart Targets
Creators: name: Doğan, B.
name: Erdil, A.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Matching Theory
University Admissions
Affirmative Action

description: UK universities advertise the degree majors (courses) they offer, and every year over 700,000 students apply to their chosen courses. For each of their courses, universities have an intake target (the number of students to admit) and an access target (the number of disadvantaged students to admit). Depending on student demand, each university would like to adjust these course-level targets to meet its aggregate (university-level) targets. We design a centralised system which provides universities with the exibility to optimally adjust their targets, makes it safe for students to reveal preferences truthfully, and quickly achieves fair and stable market clearing.
4d S-duality wall and SL(2, ℤ) relations
Creators: name: Bottini, LE
name: Hwang, C
name: Pasquetti, S
name: Sacchi, M
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Regular Article - Theoretical Physics
Duality in Gauge Field Theories
Supersymmetric Gauge Theory
Supersymmetry and Duality

description: Abstract In this paper we present various 4d$$ \mathcal{N} $$ N = 1 dualities involving theories obtained by gluing two E[USp(2N)] blocks via the gauging of a common USp(2N) symmetry with the addition of 2L fundamental matter chiral fields. For L = 0 in particular the theory has a quantum deformed moduli space with chiral symmetry breaking and its index takes the form of a delta-function. We interpret it as the Identity wall which identifies the two surviving USp(2N) of each E[USp(2N)] block. All the dualities are derived from iterative applications of the Intriligator-Pouliot duality. This plays for us the role of the fundamental duality, from which we derive all others. We then focus on the 3d version of our 4d dualities, which now involve the $$ \mathcal{N} $$ N = 4 T[SU(N)] quiver theory that is known to correspond to the 3d S-wall. We show how these 3d dualities correspond to the relations S2 = −1, S−1S = 1 and STS = T−1S−1T−1 for the S and T generators of SL(2, ℤ). These observations lead us to conjecture that E[USp(2N)] can also be interpreted as a 4d S-wall.
Large variation in participant eligibility criteria used in plantar heel pain research studies - a systematic review
Creators: name: Riel, Henrik
name: Plinsinga, Melanie Louise
name: Delahunt, Eamonn
name: Jensen, Martin Bach
name: Landorf, Karl
name: van Middelkoop, Marienke
name: Roddy, Edward
name: Rathleff, Michael Skovdal
name: Vicenzino, Bill
name: Olesen, Jens Lykkegaard
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 4207
subject: Sports science and exercise

description: Introduction: Variable eligibility criteria across studies on plantar heel pain may result in compromising the generalisability of meta-analyses when heterogeneity is not accounted for. We aimed to explore: (i) heterogeneity of participant eligibility criteria in studies that have investigated plantar heel pain, and (ii) associations between key eligibility criteria and the characteristics of the participants included in the study. Methods: In this systematic review with narrative synthesis, we extracted participant eligibility criteria, and participants’ age, body mass index (BMI), symptom duration and pain level from published studies on plantar heel pain. We performed a content analysis of criteria and aligned overarching criteria to the International Classification of Functioning, Disability and Health (ICF). We pooled studies that used the same thresholds for participant eligibility criteria into sub-groups. We also pooled and reported studies that did not have any eligibility criteria for the quantitative characteristics to use their data for reference values and pooled studies that did not have any eligibility criteria for the characteristics as reference. Results: Two hundred and fourteen articles were included. The most reported participant eligibility criteria (as aligned to the ICF) related to body structures/function and personal factors. Age, BMI, symptom duration and pain level were used with various ranges and/or thresholds across studies (age was reported in 23 different ways across 97 studies; BMI 7/13; symptom duration 14/100; and pain level 8/31). When eligibility criteria included thresholds close to the reference value of a participant characteristic, characteristics were associated with criteria (e.g., younger participants when an upper age threshold was used). Conclusion: Participant eligibility criteria in studies on plantar heel pain vary widely; studies differed substantially in their use of quantitative thresholds. Participant characteristics of samples in studies were associated with the criteria used. This study emphasises a need for adjusting for participant heterogeneity in systematic reviews to improve their validity.
title: ADCO, Cartulaire de Cîteaux pour les possessions de Dijon et du Dijonnais (XVe siècle), Cart. 175 (11 H 479), 115 folios, f. 0236
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2017
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de Cîteaux pour les possessions de Dijon et du Dijonnais (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 175 (11 H 479), 115 folios, f. 0236, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Dijon et du Dijonnais (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 175 (11 H 479), 115 folios, f. 0236, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Human dietary intake and hazard characterization for residues of neonicotinoides and organophosphorus pesticides in Egyptian honey
Creators: name: Naggar, Yahya Al
name: Codling, Garry
name: Giesy, John P.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: In two recently published reports, hazards posed by dietary exposure to organophosphate and neonicotinoid plant protection products on the European honey bee (Apis mellifera L.) in Egypt were investigated. Using concentrations reported in those studies, an assessment of hazards posed by these two classes of insecticides to humans due to consumption of Egyptian honey from the Nile Delta during both spring and summer was performed. Twenty-eight compounds including metabolites were assessed for exposure of adult Egyptians based on the best- and worst-case scenarios. Even for the worst-case scenario, exposure to these two classes of pesticides in honey was 15-fold less than hazard index value of 1.0 for adverse effects on humans. Based upon this analysis, people exposed to these insecticides through consumption of honey products would be unlikely to exhibit adverse health outcomes.
D1.3: Lessons learnt repository of TIME4CS
Creators: name: Abril Herrera
name: Haklay, Muki
Publisher: name: Zenodo
Year: 2022
Subjects: Citizen Science
Institutional Changes
Case studies

description: The current document, titled “Lessons learnt repository of TIME4CS: Building the TIME4CS knowledge base framework” has been developed within the structure of the TIME4CS project funded by the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No 101006201.
 This document synthesises the learnings of the case studies collected in Task 1.1 and the outcomes of D1.1 and D1.2, studying the Intervention Areas (IA) to define the key elements and drivers necessary for successful institutional transformation.
 For doing this, the present document summarises some of the most important points made throughout the previous work of TIME4CS (such as D1.2 Best practices repository of TIME4CS front-runners); defines the tailoring of a methodology for understanding the successful institutional transformation in support of citizen science in Research Performing Organisations (RPOs); describes some of the pathways for such a success in RPOs by detailing the results of the Fuzzy sets Qualitative Comparative Analysis (FsQCA) and links the resulting minimal formula with IA and grounding actions (a section for each IA domain) including different combinatory models to support the generation of a knowledge-based framework in support of citizen science in RPOs.
 The analysis shows that the path followed by RPOs with a higher level of Institutional Integration(InIn) of Citizen Science include the development of Citizen Science projects from different disciplines including but not limited to the Humanities, Natural Sciences, Biology/Ecology, Social Sciences and Multidisciplinary projects. In addition, having multiple Citizen Science champions seemed essential, this could be related to the fact that students and staff can provide the bottom-up pressure to push for institutional transformations; in addition, senior management citizen science champions can also influence the decision-making processes from top-down which would have a direct impact in modifying the structures in the organisations. Finally, the availability of an institutional plan that includes or considers Citizen Science and Public Engagement was a shared condition by those RPOs with higher institutional Integration. Having a Funded Coordinator appeared not to have a strong weight in supporting Institutional Integration and didn’t appear as part of the formula minimisation.
[Programme d'activités journées Julio Cortázar]
Creators: name: Asociación De Archivos De La Literatura Latinoamericana, Del Caribe Y Africana Del Siglo
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Literatura argentina
"Rayuela"
Edición Crítica
Coloquio

description: Programa de actividades de las jornadas Julio Cortázar en París (28 y 29 de mayo de 1991) y en Madrid ((3 de junio de 1991) patrocinado por Asociación de Archivos de la Literatura Latinoamericana, del Caribe y Africana del Siglo XX- Colección Archivos.
description: Notas: Dos ejemplares del documento conservados.
description: Source: Num.Ref. : JC-DY-CAR-04.177
description: Source: Localización del archivo: Centre de Recherches Latino-Américaines (CRLA–Archivos, ITEM UMR8132). MSHS - Bât. A5, 1er étage 5 rue Théodore Lefebvre - TSA21103. 86073 Poitiers cedex 9.
description: created: 1991-05-28/1991-05-29
Women's experience of unintended pregnancy and changes in contraceptive methods: evidence from a nationally representative survey
Creators: name: Khan, MN
name: Islam, Md
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3215
subject: Reproductive medicine
classificationCode: 4206
subject: Public health

description: Background: Ineffective or no use of contraception following an unintended pregnancy contributes to a subsequent unintended pregnancy. This study aimed to determine whether women’s experiences of unintended pregnancies affect changing their contraceptive using patterns. Methods: We analysed the 2017/2018 Bangladesh Demographic and Health Survey data. The contraceptive switching pattern was computed by comparing women’s contraceptives using data before and after pregnancy. Women were categorised into the following three groups, depending on their patterns of contraceptive use before and after pregnancy: no change, if there were no change in contraceptive using pattern; switched to higher effective contraceptives, if changed from pre-pregnancy less effective contraceptives to post-pregnancy more effective contraceptives; switched to less effective contraceptives, if changed from pre-pregnancy more effective contraceptives to post-pregnancy less effective contraceptives. Women’s intention in the most recent pregnancy was our primary explanatory variable, classified as wanted, mistimed and unwanted. Multinomial multilevel logistics regression was used to determine the association between women’s intention in the most recent pregnancy and women’s contraceptive methods switching patterns from before to after pregnancy. Results: Around 20% of the most recent pregnancies that ended with a live birth were unintended at conception. No contraceptive use was reported by 37% of women before their pregnancies which decreased to 24% after pregnancies. Overall, around 54% of women who reported no contraceptive use before pregnancy used modern contraceptives after pregnancy. The rate was higher among women who experienced unwanted pregnancy (73.4%) than mistimed (58.8%) and wanted (53.4%) pregnancy. Experience of mistimed pregnancy was associated with a higher likelihood of no contraceptive change (aOR, 1.84, 95% CI 1.41–2.39) and switching to less effective contraceptives (aOR, 1.58, 95% CI 1.10–2.26) than switching to more effective contraceptives. However, unwanted pregnancy was not associated with any significant change in contraceptives use from before to after pregnancy. Conclusion: Experience of unintended pregnancy did not change women’s contraception using patterns, which indicates the risk of repeat unintended pregnancies and associated adverse consequences, including maternal and child morbidity and mortality. Policies to ensure access to and use of modern contraceptives among women facing unwanted or mistimed pregnancies are recommended.
Supplementary Material for: The SQ House Dust Mite SLIT-Tablet Is Well Tolerated in Patients with House Dust Mite Respiratory Allergic Disease
Creators: name: Emminger, W.
name: Hernández, M.D.
name: Cardona, V.
name: Smeenk, F.
name: Fogh, B.S.
name: Calderon, M.A.
name: De Blay, F.
name: Backer, V.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background: The SQ house dust mite (HDM) SLIT-tablet (ALK, Denmark) addresses the underlying cause of HDM respiratory allergic disease, and a clinical effect has been demonstrated for both HDM allergic rhinitis and allergic asthma. Here, we present pooled safety data from an adult population with HDM respiratory allergy, with particular focus on the impact of asthma on the SQ HDM SLIT-tablet tolerability profile. Methods: Safety data from 2 randomised double-blind, placebo-controlled clinical trials were included: MT-04: 834 adults with HDM allergic asthma not well controlled by inhaled corticosteroids and with HDM allergic rhinitis, and MT-06: 992 adults with moderate-to-severe HDM allergic rhinitis despite the use of allergy pharmacotherapy and with or without asthma. Results: The proportion of subjects experiencing adverse events (AEs) was greater in the active treatment group (12 SQ-HDM; 73% of subjects) compared to placebo (53%). The most common treatment-related AEs were local allergic reactions. No AEs were reported as systemic allergic reactions. Regardless of asthma status, most AEs were mild or moderate (>97% of AEs) and the frequency of serious AEs was low. Subgroup analysis revealed no statistically significant difference in the risk of experiencing moderate or severe treatment-related AEs for subjects with asthma compared to subjects without asthma (p = 0.88). In addition, subjects with partly controlled or uncontrolled asthma were no more likely to experience moderate or severe treatment-related AEs than subjects with controlled asthma (p = 0.42). Conclusion: The SQ HDM SLIT-tablet is well tolerated, and the safety profile was comparable for subjects with HDM respiratory allergic disease irrespective of asthma status.
Todos los fuegos de Julio Cortázar
Creators: name: Saúl, Yurkievich
name: Yurkievich, Saúl
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Obras Completas de Julio Cortázar

description: Edición de "Obras Completas I – Cuentos" de Julio Cortázar por Círculo de Lectores-Galaxia Gutenberg, proyecto dirigido por Saúl Yurkievich.
description: Tipo de publicación: Periódico digital
description: Título de la publicación: Clarín
description: Periodicidad: Diario
description: Source: Num.Ref. : JC-DY-CAR-04.055
description: Source: Localización del archivo: Centre de Recherches Latino-Américaines (CRLA–Archivos, ITEM UMR8132). MSHS - Bât. A5, 1er étage 5 rue Théodore Lefebvre - TSA21103. 86073 Poitiers cedex 9.
From ‘we shall prevail’ to ‘weapon of struggle’: Populism, Chile's Unidad Popular government and Nueva Canción
Creators: name: Carrasco, Gonzalo
name: Bendrups, Daniell
name: Sanchez-Urribarri, Raul
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3603
subject: Music

description: The Chilean nueva canción ('new song') movement is one of Latin America's most enduring musical phenomena. Strongly associated with the rise of left-wing political forces in the 1960s, and then with anti-dictatorship protests in the 1970s and 1980s, nueva canción is deeply embedded in Chilean political consciousness. This article provides a new perspective on the movement by exploring its populist elements and considering these in relation to Communist Party cultural policy. It focuses on a significant historical moment - the Chilean Communist Party's 1971 Assembly on the Chilean Revolution and the Problems of Culture - to ascertain how the political potential of 'Chilean new song' was viewed by this key partner in the Chilean coalition government. Through this examination, this article offers new insight into the political positioning of CNS, illustrating the movement's socio-political role in terms of the broader ideological principles and imperatives of the vía chilena ('Chilean road') to socialism.
The Role of Government in a Partial Transition from Public to Private in the Expanding Australian Protected Area System
Creators: name: Kirkpatrick, J
name: Fielder, J
name: Davison, A
name: Pearce, Lilian
name: Cooke, B
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 4104
subject: Environmental management
classificationCode: 4408
subject: Political science
subject: FOS: Political science
classificationCode: 4406
subject: Human geography

description: Since the 1980s in democratic societies, neoliberal reforms and neofeudal governance have transferred the delivery of many public goods and services from governments to non-government actors. Privatisation is a core neoliberal agenda, but little is known of the nature and extent of its application to nature conservation through reservation. We investigate the degree of privatisation of the expanding protected area system in our case study areas of Australia and Tasmania, hypothesising that governments have: disrupted public agencies managing the protected area estate by repeated reorganisation; diverted public funds from public to private protected areas; and increasingly alienated public reserves for subsidised private profit from tourism. We found frequent restructuring of agencies managing protected areas. Although Federal Government expenditure on private reserves increased markedly in the twenty-first century, so did expenditure on public conservation reserves. All States except Queensland increased public protected area funding. Direct subsidisation of private reserves by government has not had a steady upward trajectory. In contrast, subsidisation of private alienation of public conservation reserves for tourism may have accelerated in the twenty-first century. We conclude that, while Australian governments see value in protected areas as a source of economic development and electoral advantage, they are agnostic on ownership.
Marrow compartment contribution to cortical defect healing
Creators: name: Bernhardsson, Magnus
name: Tätting, Love
name: Sandberg, Olof
name: Schilcher, Jörg
name: Aspenberg, Per
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology

description: Background and purpose — Healing of shaft fractures is commonly described as regards external callus. We wanted to clarify the role of the bone marrow compartment in the healing of stable shaft fractures. Patients and methods — A longitudinal furrow was milled along the longitudinal axis of the femoral shaft in mice. The exposed bone marrow under the furrow was scooped out. The mice were then randomized to no further treatment, or to receiving 2 silicone plugs in the medullary canal distal and proximal to the defect. The plugs isolated the remaining marrow from contact with the defect. Results were studied with histology and flow cytometry. Results — Without silicone plugs, the marrow defect was filled with new bone marrow-like tissue by day 5, and new bone was seen already on day 10. The new bone was seen only at the level of the cortical injury, where it seemed to form simultaneously in the entire region of the removed cortex. The new bone seemed not to invade the marrow compartment, and there was a sharp edge between new bone and marrow. The regenerated marrow was similar to uninjured marrow, but contained considerably more cells. In the specimens with plugs, the marrow compartment was either filled with loose scar tissue, or empty, and there was only minimal bone formation, mainly located around the edges of the cortical injury. Interpretation — Marrow regeneration in the defect seemed to be a prerequisite for normal cortical healing. Shaft fracture treatment should perhaps pay more attention to the local bone marrow.
Targeting MDM4 as a Novel Therapeutic Approach in Prostate Cancer Independent of p53 Status
Creators: name: Mejia-Hernandez, Javier Octavio
name: Raghu, Dinesh
name: Caramia, Franco
name: Clemons, Nicholas
name: Fujihara, Kenji
name: Riseborough, Thomas
name: Teunisse, Amina
name: Jochemsen, Aart G
name: Abrahmsen, Lars
name: Blandino, Giovanni
name: Russo, Andrea
name: Gamell, Cristina
name: Fox, Stephen B
name: Mitchell, Catherine
name: Takano, Elena A
name: Byrne, David
name: Miranda, Panimaya Jeffreena
name: Saleh, Reem
name: Thorne, Heather
name: Sandhu, Shahneen
name: Williams, Scott G
name: Keam, Simon P
name: Haupt, Ygal
name: Haupt, Sue
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3211
subject: Oncology and carcinogenesis

description: Metastatic prostate cancer is a lethal disease in patients incapable of responding to therapeutic interventions. Invasive prostate cancer spread is caused by failure of the normal anti-cancer defense systems that are controlled by the tumour suppressor protein, p53. Upon mutation, p53 malfunctions. Therapeutic strategies to directly re-empower the growth-restrictive capacities of p53 in cancers have largely been unsuccessful, frequently because of a failure to discriminate responses in diseased and healthy tissues. Our studies sought alternative prostate cancer drivers, intending to uncover new treatment targets. We discovered the oncogenic potency of MDM4 in prostate cancer cells, both in the presence and absence of p53 and also its mutation. We uncovered that sustained depletion of MDM4 is growth inhibitory in prostate cancer cells, involving either apoptosis or senescence, depending on the cell and genetic context. We identified that the potency of MDM4 targeting could be potentiated in prostate cancers with mutant p53 through the addition of a first-in-class small molecule drug that was selected as a p53 reactivator and has the capacity to elevate oxidative stress in cancer cells to drive their death.
Preaxial polydactyly of the foot
Creators: name: Burger, Elise B
name: Baas, Martijn
name: Hovius, Steven E R
name: A Jeannette M Hoogeboom
name: Nieuwenhoven, Christianne A Van
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Background and purpose — Preaxial polydactyly of the foot is a rare malformation and clinicians are often unfamiliar with the associated malformations and syndromes. In order to give guidelines for diagnostics and referral to a clinical geneticist, we provide an overview of the presentation using a literature review and our own patient population. Patients and methods — The literature review was based on the Human Phenotype Ontology (HPO) project. From the HPO dataset, all phenotypes describing preaxial polydactyly were obtained and related diseases were identified and selected. An overview was generated in a heatmap, in which the phenotypic contribution of 12 anatomical groups to each disease is displayed. Clinical cases were obtained from our hospital database and were reviewed in terms of phenotype, genotype, heredity, and diagnosed syndromes. Results — From the HPO dataset, 21 diseases were related to preaxial polydactyly of the foot. The anatomical groups with the highest phenotypic contribution were lower limb, upper limb, and craniofacial. From our clinical database, we included 76 patients with 9 different diseases, of which 27 had a GLI3 mutation. Lower limb malformations (n = 55), upper limb malformations (n = 59), and craniofacial malformations (n = 32) were most frequently observed. Malformations in other anatomical groups were observed in 27 patients. Interpretation — Preaxial polydactyly of the foot often presents with other upper and lower limb malformations. In patients with isolated preaxial polydactyly of the foot, referral to a clinical geneticist is not mandatory. In patients with additional malformations, consultation with a clinical geneticist is recommended. When additional limb malformations are present, analysis of GLI3 is most feasible.
title: ADCO, Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Cart. 23 (G 127), 310 folios, f. 00233
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: Petot, Frédéric
name: CG21/F.PETOT/2011
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Archives départementales de la Côte-d'Or, Cart. 23 (G 127), 310 folios, f. 00233, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Archives départementales de la Côte-d'Or, Cart. 23 (G 127), 310 folios, f. 00233, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Web-Based Risk Prediction Tool for an Individual's Risk of HIV and Sexually Transmitted Infections Using Machine Learning Algorithms: Development and External Validation Study
Creators: name: Xu, X
name: Yu, Z
name: Ge, Z
name: Chow, EPF
name: Bao, Y
name: Ong, JJ
name: Li, W
name: Wu, Jinrong
name: Fairley, CK
name: Zhang, L
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 4203
subject: Health services and systems

description: Background: HIV and sexually transmitted infections (STIs) are major global public health concerns. Over 1 million curable STIs occur every day among people aged 15 years to 49 years worldwide. Insufficient testing or screening substantially impedes the elimination of HIV and STI transmission. Objective: The aim of our study was to develop an HIV and STI risk prediction tool using machine learning algorithms. Methods: We used clinic consultations that tested for HIV and STIs at the Melbourne Sexual Health Centre between March 2, 2015, and December 31, 2018, as the development data set (training and testing data set). We also used 2 external validation data sets, including data from 2019 as external "validation data 1" and data from January 2020 and January 2021 as external "validation data 2." We developed 34 machine learning models to assess the risk of acquiring HIV, syphilis, gonorrhea, and chlamydia. We created an online tool to generate an individual's risk of HIV or an STI. Results: The important predictors for HIV and STI risk were gender, age, men who reported having sex with men, number of casual sexual partners, and condom use. Our machine learning-based risk prediction tool, named MySTIRisk, performed at an acceptable or excellent level on testing data sets (area under the curve [AUC] for HIV=0.78; AUC for syphilis=0.84; AUC for gonorrhea=0.78; AUC for chlamydia=0.70) and had stable performance on both external validation data from 2019 (AUC for HIV=0.79; AUC for syphilis=0.85; AUC for gonorrhea=0.81; AUC for chlamydia=0.69) and data from 2020-2021 (AUC for HIV=0.71; AUC for syphilis=0.84; AUC for gonorrhea=0.79; AUC for chlamydia=0.69). Conclusions: Our web-based risk prediction tool could accurately predict the risk of HIV and STIs for clinic attendees using simple self-reported questions. MySTIRisk could serve as an HIV and STI screening tool on clinic websites or digital health platforms to encourage individuals at risk of HIV or an STI to be tested or start HIV pre-exposure prophylaxis. The public can use this tool to assess their risk and then decide if they would attend a clinic for testing. Clinicians or public health workers can use this tool to identify high-risk individuals for further interventions.
Unilateral Strength Training Imparts a Cross-Education Effect in Unilateral Knee Osteoarthritis Patients
Creators: name: Bowen, Warren
name: Frazer, Ashlyn
name: Tallent, J
name: Pearce, Alan
name: Kidgell, DJ
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3202
subject: Clinical sciences
classificationCode: 3209
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 4207
subject: Sports science and exercise

description: Background: Worldwide, 86 million individuals over the age of 20 were diagnosed with knee osteoarthritis (KOA) in 2020. Hallmark features of KOA are the loss in knee extensor strength, increasing knee pain severity, and deficits in functional performance. There is a critical need for the investigation into potential cost-effective therapeutic interventions in the treatment of KOA. A potential therapeutic option is the cross-education phenomenon. Methods: This was a non-blinded randomized control trial, with a 4-week intervention, with a pre, post and follow-up assessment (3 months post intervention). Outcome measures of isometric knee extensor strength, rectus femoris muscle thickness and neuromuscular activation were assessed at all-time points. Results: Compared to age-matched KOA controls, 4 weeks of unilateral strength training in end-stage KOA patients increased strength of the untrained affected KOA limb by 20% (p < 0.05) and reduced bilateral hamstring co-activation in the KOA intervention group compared to the KOA control group (p < 0.05). Conclusions: A 4-week-long knee extensor strength training intervention of the contralateral limb in a cohort with diagnosed unilateral KOA resulted in significant improvements to knee extensor strength and improved neuromuscular function of the KOA limb. Importantly, these results were maintained for 3 months following the intervention.
Targeted Whole Genome Sequencing (TWG-Seq) of Cucumber Green Mottle Mosaic Virus Using Tiled Amplicon Multiplex PCR and Nanopore Sequencing
Creators: name: Mackie, Joanne
name: Kinoti, WM
name: Chahal, SI
name: Lovelock, DA
name: Campbell, PR
name: Tran-Nguyen, LTT
name: Rodoni, Brendan
name: Constable, Fiona
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 30
subject: Agricultural, veterinary and food sciences

description: Rapid and reliable detection tools are essential for disease surveillance and outbreak management, and genomic data is essential to determining pathogen origin and monitoring of transmission pathways. Low virus copy number and poor RNA quality can present challenges for genomic sequencing of plant viruses, but this can be overcome by enrichment of target nucleic acid. A targeted whole genome sequencing (TWG-Seq) approach for the detection of cucumber green mottle mosaic virus (CGMMV) has been developed where overlapping amplicons generated using two multiplex RT-PCR assays are then sequenced using the Oxford Nanopore MinION. Near complete coding region sequences were assembled with ≥100× coverage for infected leaf tissue dilution samples with RT-qPCR cycle quantification (Cq) values from 11.8 to 38 and in seed dilution samples with Cq values 13.8 to 27. Consensus sequences assembled using this approach showed greater than 99% nucleotide similarity when compared to genomes produced using metagenomic sequencing. CGMMV could be confidently detected in historical seed isolates with degraded RNA. Whilst limited access to, and costs associated with second-generation sequencing platforms can influence diagnostic outputs, the portable Nanopore technology offers an affordable high throughput sequencing alternative when combined with TWG-Seq for low copy or degraded samples.
Assessing teleoperation interfaces using task performance for glovebox operations: a step towards assisted autonomy
Creators: name: Tokatli, Ozan
name: Lopez, Erwin
name: Herrman, Guido
Publisher: name: Zenodo
Year: 2022
Subjects: HRI
user assessment
eye tracking
robotics
glovebox
nuclear
haptics

description: Tele-manipulation is indispensable for the nuclear industry, since teleoperated robots eliminate the radiation hazard problem for the operator. However, understanding the performance limits of teleoperated robots for nuclear decommissioning tasks is not clearly answered in the literature. We evaluate the performance of tele-manipulation of a robotic arm inside a glovebox by designing a test based on radiation surveying and compare it to manual task execution. Our results show that the current commercial systems are flexible, yet insufficient, as their task performance is significantly lower compared to manual operation.
description: Second fund from EP/W001128/1, Robotics and Artificial Intelligence for Nuclear Plus (RAIN+) Sensors funded from EP/T011491/1, National Nuclear User Facility for Hot Robotics (NNUF-HR)
Fog Computing: Strategies for Optimal Performance and Cost Effectiveness
Creators: name: Alraddady, Sara Ibraheem S
name: Soh, Ben
name: AlZain, MA
name: Li, Alice
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 4009
subject: Electronics, sensors and digital hardware

description: The proliferation of IoT devices has amplified the challenges for cloud computing, causing bottleneck congestion which affects the delivery of the required quality of service. For some services that are delay sensitive, response time is extremely critical to avoid fatalities. Therefore, Cisco presented fog computing in 2012 to overcome such limitations. In fog computing, data processing happens geographically close to the data origin to reduce response time and decrease network and energy consumption. In this paper, a new fog computing model is presented, in which a management layer is placed between the fog nodes and the cloud data centre to manage and control resources and communication. This layer addresses the heterogeneity nature of fog computing and complex connectivity that are considered challenges for fog computing. Sensitivity analysis using simulation is conducted to determine the efficiency of the proposed model. Different cluster configurations are implemented and evaluated in order to reach the optimal clustering method. The results show that the management layer improves QoS, with less bandwidth consumption and execution time.
Marrow compartment contribution to cortical defect healing
Creators: name: Bernhardsson, Magnus
name: Tätting, Love
name: Sandberg, Olof
name: Schilcher, Jörg
name: Aspenberg, Per
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology

description: Background and purpose — Healing of shaft fractures is commonly described as regards external callus. We wanted to clarify the role of the bone marrow compartment in the healing of stable shaft fractures. Patients and methods — A longitudinal furrow was milled along the longitudinal axis of the femoral shaft in mice. The exposed bone marrow under the furrow was scooped out. The mice were then randomized to no further treatment, or to receiving 2 silicone plugs in the medullary canal distal and proximal to the defect. The plugs isolated the remaining marrow from contact with the defect. Results were studied with histology and flow cytometry. Results — Without silicone plugs, the marrow defect was filled with new bone marrow-like tissue by day 5, and new bone was seen already on day 10. The new bone was seen only at the level of the cortical injury, where it seemed to form simultaneously in the entire region of the removed cortex. The new bone seemed not to invade the marrow compartment, and there was a sharp edge between new bone and marrow. The regenerated marrow was similar to uninjured marrow, but contained considerably more cells. In the specimens with plugs, the marrow compartment was either filled with loose scar tissue, or empty, and there was only minimal bone formation, mainly located around the edges of the cortical injury. Interpretation — Marrow regeneration in the defect seemed to be a prerequisite for normal cortical healing. Shaft fracture treatment should perhaps pay more attention to the local bone marrow.