cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2 of Assessing gait, balance, and muscle strength among breast cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN): study protocol for a randomized controlled clinical trial
Creators: name: Teran-Wodzinski, Patricia
name: Haladay, Douglas
name: Vu, Tuan
name: Ji, Ming
name: Coury, Jillian
name: Adams, Alana
name: Schwab, Lauren
name: Visovsky, Constance
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 2. Ethical Approval.
title: JIP 2021
Publisher: name: RESEAU POLYTECH
Year: 2021

description: La journée Initiatives Pédagogiques JIP 2020-2021 organisée par l’Université Paris-Saclay    Le thème abordé est : Comment la pandémie actuelle questionne nos enseignements et dans quelle mesure s’opère une transformation vers l’hybridation ?
NATIONAL FINANCIAL SYSTEM AND FAMILY FARMING: INNOVATIONS, BENEFITS AND LIMITS TO CREDIT COOPERATIVE
Creators: name: Opuszka, Paulo Ricado
name: ANDRESSA CASTRO
Publisher: name: figshare
Year: 2014
Subjects: subject: Law
subject: FOS: Law

description: The purpose of this paper is to analyze from the family farm Complementary Law No. 130 of April 17, 2009 the credit union and the limits, the example System Cresol retrieval and regulatory evolution of this important segment of the financial system. Credit unions are financial institutions that have the purpose to provide financial services exclusively to its members. Developed to the extent that legal rules were edited, responsible for deciding on their operation and their assignments. The most recent normative contribution to the segment is given by the advent of Complementary Law n. 130 of 17 April 2009, which was legally Article 192 of the Constitution of 1988. The research methodology, the aims, was reflexive and dialectic, proposing to describe and explain the innovations. As for the technical procedures for analyzing literature and documents, laws and magazines as well as internet publications. Finally, as the system Cresol Cooperative Credit preserve their identity against the new governance model proposed by law.
Additional file 1 of Heterogeneous treatment effects of intensive glycemic control on major adverse cardiovascular events in the ACCORD and VADT trials: a machine-learning analysis
Creators: name: Edward, Justin A.
name: Josey, Kevin
name: Bahn, Gideon
name: Caplan, Liron
name: Reusch, Jane E. B.
name: Reaven, Peter
name: Ghosh, Debashis
name: Raghavan, Sridharan
Publisher: name: figshare
Year: 2022
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: Additional file 1: Table S1. Baseline predictor variables common to VADT and ACCORD studies included in causal forest analysis. Table S2. Variable importance ranks for cardiovascular disease events and heterogeneous treatment effects across ACCORD, VADT, and pooled samples. Figure S1. Correlation of variable importance rank from causal forest in the VADT and ACCORD studies. Figure S2. Comparison of subgroup effects based on subgroup-specific rates of major adverse cardiovascular events (MACE) stratified by study. Table S3. Risk differences of mortality between intensive and standard glycemic control arms in in eight subgroups.
Gut microbiota and plasma amino acids profile connections in patients with coronary artery disease and atrial fibrillation
Creators: name: Melnychuk, Iryna
Publisher: name: https://ijmsdr.org/
Year: 2024
Subjects: coronary artery disease
atrial fibrillation,
amino acids,
gut microbiota composition,
gut microbiota metabolites.

description: The aim of our work to check the connections between gut microbiota composition and plasma amino acids profile in patients with coronary artery disease (CAD) and atrial fibrillation (AF). Materials and methods: 300 patients were divided into 3 groups: first (CAD) – 149 patients with CAD but without arrhythmias, second (CAD+AF) – 124 patients with CAD and AF paroxysm and control group – 27 patients without CAD and arrhythmias. Plasma AA level was detected by ion exchange liquid column chromatography method. 16-S rRNA sequencing checked gut microbiota composition. Results: The II group patients are characterized by a significant increase in Actinobacter Spp. and a decrease in Blautia Spp., Bacteroides Thetaiotaomicron;a significant increase in glutamate, branched-chain amino acids, Fishers’ ratio, and a decrease in glycine levels (P<0.05). Pathogenic species have such significant correlations: Streptococcus Spp. with tyrosine (r=0.301), phenylalanine (r=0.340), aromatic amino acids (r=0.345), Fishers’ ratio (r=0.319); Escherichiacoli with arginine (r=-0.331), serine (r=-0.337), valine (r=-0.332);(P<0.05). Probiotic species have such significant correlations: Bifidobacterium Spp. with glycine (r=0.505), Fishers’ ratio (r=-0.371); Blautia Spp. with ornithine (r=0.329), glycine (r=0.414), alanine (r=0.316); Eubacteriumrectale. with ornithine (r=0.379), glycine (r=0.467), alanine (r=0.384), Fishers’ ratio (r=0.418);(P<0.05).Conclusions: Plasma amino acids and gut microbiota are closely connected.
Natural anti-A and Tn-cross-reactive IgM arise from developmental O-GalNAc glycosylations.*
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Developmental Biology
subject: Zoology
subject: 60114 Systems Biology
subject: Structural Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics

description: While neither N- nor O-linked N-acetyl-D-galactosamine (D-GalNAc)-determined, native blood group A-like glycans have yet been demonstrated in prokaryotic microorganisms as a source of the human “natural” anti-A/B isoagglutinin production, the O-linked GalNAc glycan-bearing ovarian glycolipids, discovered in C57BL/10 mice, are complementary to the syngeneic anti-A-reactive, secretory immunoglobulin M (IgM), which does not appear in animals that underwent ovariectomy prior to the onset of puberty. This murine anti-A “auto” antibody and the human innate or non-immune anti-A isoagglutinin show identical serological reaction patterns. In mouse and man, this antibody molecule most likely obtains its complementarity from the early trans-species O-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion that completes the cell differentiation processes and results in release of glycan-depleted, complementary protein(s). This mechanism of IgM formation might be established through expression of germline-specific serine residues that reveal the structure of the volatilely expressed, “lost” glycan. Consequently, the early or first O-GalNAc glycosylations of proteins appear metabolically related to those of the mucin-type, “aberrant” monosaccharide GalNAcα1-O-Ser/Thr-R also referred to the Tn antigen and explain the anti-Tn cross-reactivity of anti-A-specific immunoglobulins and the pronounced occurrence of cross-reactive anti-Tn antibody in plasma from humans of histo (blood) group O. In fact, in the human blood group O, an A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur, impacting the levels of the anti-Tn antibody, which may function as a growth regulator that depending on its levels, may initiate a complex process of growth inhibition through enzyme-substrate competition with subsequent trans-species O-GalNAc-glycosylations.
PLANT BIOTECHNOLOGY AND SUSTAINABILITY: BUILDING THE COMMON DIALOGUE FOR SURVIVAL
Creators: name: Neto, Miguel Kfouri
name: MARIA DA GLÓRIA COLUCCI
Publisher: name: figshare
Year: 2014
Subjects: subject: Law
subject: FOS: Law

description: Biotechnology and sustainability seem to represent, to a first look at modern building opposite sides of the quality of life and the struggle for survival of the planet. Solidarity composed, or at least should compose the ethical-political and legal basis for all public initiatives in the preservation of life, security and freedom of present and future generations. Joining sustainability and solidarity highlight the common purpose of maintaining harmony and stability of natural resources, according to constitutional provisions in force (article. 3 and 225 of the Higher Law, 1988). Thus, the common survival of living beings due to government measures combined with biotechnological innovations of individuals (entrepreneurs, NGO'S, universities, researchers etc.), all segments embedded in the construction of the "Future We Want". The initial sketch on paper, on January 10, 2012, the results for analysis by the United States in Rio +20, the UN Conference on Sustainable Development, the apex body intended to represent the peoples (UN), focus new challenges in implementation, acceleration and strengthening of a "green" economy to eradicate poverty and extreme poverty on the planet.
Additional file 1 of Predictors for patient satisfaction of a single intra-articular injection of crosslinked hyaluronic acid combined with mannitol (HANOX-M-XL) in patients with temporomandibular joint osteoarthritis. Results of a prospective open-label pilot study (HAPPYMINI-ARTEMIS trial)
Creators: name: Baron, Dominique
name: Baron, Hugo
name: Baerer, Catherine
name: Bodere, Céline
name: Conrozier, Thierry
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Additional file 1.
Additional file 1 of The effects of oclacitinib treatment on antimicrobial usage in allergic dogs in primary practice: an Australia wide case-control study
Creators: name: Rynhoud, Hester
name: Croton, Catriona
name: Henry, Grace
name: Meler, Erika
name: Gibson, Justine S.
name: Soares Magalhaes, Ricardo J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 1.
Natural anti-A and Tn-cross-reactive IgM arise from developmental O-GalNAc glycosylations.*
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Developmental Biology
subject: Zoology
subject: 60114 Systems Biology
subject: Structural Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics

description: While neither N- nor O-linked N-acetyl-D-galactosamine (D-GalNAc)-determined, native blood group A-like glycans have yet been demonstrated in prokaryotic microorganisms as a source of the human “natural” anti-A/B isoagglutinin production, the O-linked GalNAc glycan-bearing ovarian glycolipids, discovered in C57BL/10 mice, are complementary to the syngeneic anti-A-reactive, secretory immunoglobulin M (IgM), which does not appear in animals that underwent ovariectomy prior to the onset of puberty. This murine anti-A “auto” antibody and the human innate or non-immune anti-A isoagglutinin show identical serological reaction patterns. In mouse and man, this antibody molecule most likely obtains its complementarity from the early trans-species O-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion that completes the cell differentiation processes and results in the release of glycan-depleted, complementary protein(s). This mechanism of IgM formation might be established through expression of germline-specific serine residues that reveal the structure of the volatilely expressed, “lost” glycan. Consequently, the early or first O-GalNAc glycosylations of proteins appear metabolically related to those of the mucin-type, “aberrant” monosaccharide GalNAcα1-O-Ser/Thr-R also referred to the Tn antigen and explain the anti-Tn cross-reactivity of anti-A-specific immunoglobulins and the pronounced occurrence of cross-reactive anti-Tn antibody in plasma from humans of histo (blood) group O. In fact, in the human blood group O, an A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur, impacting the levels of the anti-Tn antibody, which may function as a growth regulator that depending on its levels, may initiate a complex process of growth inhibition through enzyme-substrate competition with subsequent trans-species O-GalNAc-glycosylations.
ELECTRONIC PROCESS LIKE CITIZENSHIP INSTRUMENT
Creators: name: Bertoncini, Mateus Eduardo Siqueira
name: FELIPPE ABU-JAMRA CORRÊA
Publisher: name: figshare
Year: 2014
Subjects: subject: Law
subject: FOS: Law

description: Introduced in Brazilian reality less than two decades ago, the electronic process presents itself as one of the solutions for the slowness of Brazil´s justice, as it´s might be an important mechanism designed to give greater efficiency on jurisdictional decisions, redounding in benefits such as cost-cutting and decreasing the judicial procedural length . The continuous monitoring of electronic process has shown that it´s a mechanism that can be effectively helpful in the implementation of the Brazilian 1.988 Constitution “fundamental right to reasonable processing time”.
Natural anti-A and Tn-cross-reactive IgM arise from developmental O-GalNAc glycosylations.*
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Developmental Biology
subject: Zoology
subject: 60114 Systems Biology
subject: Structural Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics

description: While neither N- nor O-linked N-acetyl-D-galactosamine (D-GalNAc)-determined, native blood group A-like glycans have yet been demonstrated in prokaryotic microorganisms as a source of the human “natural” anti-A/B isoagglutinin production, the O-linked GalNAc glycan-bearing ovarian glycolipids, discovered in C57BL/10 mice, are complementary to the syngeneic anti-A-reactive, secretory immunoglobulin M (IgM), which does not appear in animals that underwent ovariectomy prior to the onset of puberty. This murine anti-A “auto” antibody and the human innate or non-immune anti-A isoagglutinin show identical serological reaction patterns. In mouse and man, this antibody molecule most likely obtains its complementarity from the early trans-species O-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion that completes the cell differentiation processes and results in the release of O-glycan-depleted, complementary protein(s). This mechanism of IgM formation might be established through expression of germline-specific serine residues that reveal the structure of the volatilely expressed, “lost” glycan. Consequently, the early or first O-GalNAc glycosylations of proteins appear metabolically related to those of the mucin-type, “aberrant” monosaccharide GalNAcα1-O-Ser/Thr-R also referred to the Tn antigen and explain the anti-Tn cross-reactivity of anti-A-specific immunoglobulins and the pronounced occurrence of cross-reactive anti-Tn antibody in plasma from humans of histo (blood) group O. In fact, in the human blood group O, an A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur, impacting the levels of the anti-Tn antibody, which may function as a growth regulator that depending on its levels, may initiate a complex process of growth inhibition through enzyme-substrate competition with subsequent trans-species O-GalNAc-glycosylations.
Additional file 2 of The ten-year risk of developing cardiovascular disease among public health workers in North-Central Nigeria using Framingham and atherogenic index of plasma risk scores
Creators: name: Olubiyi, Olubunmi Abiola
name: Rotimi, Bosede Folashade
name: Afolayan, Munirat Ayoola
name: Alatishe-Muhammad, Bilqis Wuraola
name: Olubiyi, Olufemi Mubo
name: Balami, Ahmed Dahiru
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 2.
THE LABOUR COURT COMPETENCE FOR THE JUDGEMENT OF INDEPENDENT SERVICE PROVIDER: ANALYSIS OF THE DECISION OF TST IN CLASS ACTION PROPOSED TO UNION OF MEDICAL AT THE PARANÁ AGAINST THE PROVIDER OF HEALTH PLANS
Creators: name: Luiz Eduardo Gunther
name: LUIZ GUSTAVO DE ANDRADE
Publisher: name: figshare
Year: 2014
Subjects: subject: Law
subject: FOS: Law

description: The present study intends to analyze the judgment rendered by the TST in which recognized the jurisdiction of the Labour Court to judge the legal employment relationship between the independent physicians who provide services for Health Plans and the Plan Operators Health. Makes the working relationship between differentiation and consumer relationship and concludes at the end, that this type of work falls under the jurisdiction of the Labour Court, due to the expansion of competence promoted by the EC 45.
SOCIAL RESPONSIBILITY OF BUSINESS AND UNDERCITIZENSHIP GUIDELINES FOR A REFLECTION BASED ON THE CONSTITUTION
Creators: name: Silva, Marcos Alves Da
name: VIVIANE COÊLHO DE SÉLLOS KNOERR
Publisher: name: figshare
Year: 2014
Subjects: subject: Law
subject: FOS: Law

description: The modern business activity was born under the auspices of the exercise of private autonomy to the satisfaction of the interests of holders of the means of production. This is its meaning in the liberal State. In a democratic welfare State, which gains special semblance, in Brazil, with the 1988 Constitution, the function and meaning of the business should be resized, especially when you take into account the fact that the Brazilian society to be counted among the peripheral societies, with low levels of human development and marked by striking social inequalities. So this reflection aims to raise some guidelines for a reflection on the social responsibility of business, with reference to the board axiological fixed by the constitutional principles. This is not a conclusive text, but rather a reflection that raises questions about the social role of business in a peripheral country that signed in the Constitution the goal: to build a just and solidarity society.
IN03205 Alutnuvara Slab Inscription 1
Creators: name: Paranavitana, S.
Publisher: name: Zenodo
Year: 2020
Subjects: IN03205
Epigraphia Zeylanica
Alutnuvara

description: IN03205 Alutnuvara Slab Inscription 1 - Transcript and Translation Source: Paranavitana, S. (1934–41). ‘No. 34. Alutnuvara Slab-Inscriptions,’ Epigraphia Zeylanica 4, pp. 261–270, I.
Additional file 3 of The ten-year risk of developing cardiovascular disease among public health workers in North-Central Nigeria using Framingham and atherogenic index of plasma risk scores
Creators: name: Olubiyi, Olubunmi Abiola
name: Rotimi, Bosede Folashade
name: Afolayan, Munirat Ayoola
name: Alatishe-Muhammad, Bilqis Wuraola
name: Olubiyi, Olufemi Mubo
name: Balami, Ahmed Dahiru
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 3.
Самоактуалізація як складова розвитку особистості в професійному вимірі
Creators: name: Zadorozhna, Anastasiia
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 520104
subject: Industrial and organisational psychology (incl. human factors)

description: Задорожна А.С. Самоактуалізація як складова розвитку особистості в професійному вимірі. Особистісні та ситуативні детермінанти здоров’я : Матеріали VIII Всеукраїнської конференції (м. Київ, 16 листопада 2023 р.) : матеріали і тези доповідей / за заг. ред. Проф О.В. Бацилєвої. Київ, 2023. С. 49-52. http://doi.org/10.6084/m9.figshare.28919744
NEW DIRECTIONS OF ATTORNEYS 'FEES OF DEFEAT IN THE JUSTICE OF WORK
Creators: name: Luiz Eduardo Gunther
name: RUSLAN LUÍS TORRICO SCHWAB
Publisher: name: figshare
Year: 2014
Subjects: subject: Law
subject: FOS: Law

description: Although the common law procedures regards the rights of the lawyer to perceive
"defeat fees", the labor legislation expressly provides the exclusivity of the Sindicate
attourney to receipt it. Faced with the amendment of laws in time and the content of
the Federal Constitution proclaimed in 1988, suggest that the Superior Courts
undestanding is outdated, given the recent decisions of the First Degree Courts and
Regional Labor Courts, through a myriad of justifications and comments that
advocate the particular prosecutor - though not belongins to a Sindicate - the right to
such fees.
Additional file 1 of Peptide hydrogel with self-healing and redox-responsive properties
Creators: name: D’Souza, Areetha
name: Marshall, Liam R.
name: Yoon, Jennifer
name: Kulesha, Alona
name: Edirisinghe, Dona I. U.
name: Chandrasekaran, Siddarth
name: Rathee, Parth
name: Prabhakar, Rajeev
name: Makhlynets, Olga V.
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Additional file 1. Contains supplementary figures S1–S17, tables S1–S3 and “Materials and Methods” section.
Natural anti-A and Tn-cross-reactive IgM arise from developmental O-GalNAc glycosylations.*
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Developmental Biology
subject: Zoology
subject: 60114 Systems Biology
subject: Structural Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics

description: While neither N- nor O-linked N-acetyl-D-galactosamine (D-GalNAc)-determined, native blood group A-like glycans have yet been demonstrated in prokaryotic microorganisms as a source of the human “natural” anti-A/B isoagglutinin production, the O-linked GalNAc glycan-bearing ovarian glycolipids, discovered in C57BL/10 mice, are complementary to the syngeneic anti-A-reactive, secretory immunoglobulin M (IgM), which does not appear in animals that underwent ovariectomy prior to the onset of puberty. This murine anti-A “auto” antibody and the human innate or non-immune anti-A isoagglutinin show identical serological reaction patterns. In mouse and man, this antibody molecule most likely obtains its complementarity from the early trans-species O-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion that completes the cell differentiation processes and results in the release of characteristic O-glycan-depleted, complementary protein(s). This mechanism of IgM formation might be established through expression of germline-specific serine residues that reveal the structure of the volatilely expressed, “lost” glycan. Consequently, the early or first O-GalNAc glycosylations of proteins appear metabolically related to those of the mucin-type, “aberrant” monosaccharide GalNAcα1-O-Ser/Thr-R also referred to the Tn antigen and explain the anti-Tn cross-reactivity of anti-A-specific immunoglobulins and the pronounced occurrence of cross-reactive anti-Tn antibody in plasma from humans of histo (blood) group O. In fact, in the human blood group O, an A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur, impacting the levels of the anti-Tn antibody, which may function as a growth regulator that depending on its levels, may initiate a complex process of growth inhibition through enzyme-substrate competition with subsequent trans-species O-GalNAc-glycosylations.
Natural anti-A and Tn-cross-reactive IgM arise from developmental O-GalNAc glycosylations.*
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Developmental Biology
subject: Zoology
subject: 60114 Systems Biology
subject: Structural Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics

description: While native blood group A-like glycans have not been demonstrated in prokaryotic microorganisms as a source of the human “natural” anti-A/B isoagglutinin production, the O-GalNAc glycan-bearing ovarian glycolipids, discovered in C57BL/10 mice, are complementary to the syngeneic anti-A-reactive immunoglobulin M (IgM), which does not appear in animals that underwent ovariectomy prior to the onset of puberty. This murine anti-A “auto” antibody and the human innate or non-immune anti-A isoagglutinin show identical serological reaction patterns. In mouse and man, this antibody molecule most likely obtains its complementarity from the early trans-species O-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion that completes the cell differentiation processes and results in the release of characteristic O-glycan-depleted, complementary protein(s). This mechanism of IgM formation might be established through expression of germline-specific serine residues that reveal the structure of the volatilely expressed, “lost” glycan. Consequently, the early or first O-GalNAc glycosylations of proteins appear metabolically related to those of the mucin-type, “aberrant” monosaccharide GalNAcα1-O-Ser/Thr-R also referred to the Tn antigen and explain the anti-Tn cross-reactivity of anti-A-specific immunoglobulins and the pronounced occurrence of cross-reactive anti-Tn antibody in plasma from humans of histo (blood) group O. In fact, in the human blood group O, an A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur, impacting the levels of the anti-Tn antibody, which may function as a growth regulator that depending on its levels, may initiate a complex process of growth inhibition through enzyme-substrate competition with subsequent trans-species O-GalNAc-glycosylations.
Additional file 1 of Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth
Creators: name: Tiensuu, Heli
name: Haapalainen, Antti M.
name: Tissarinen, Pinja
name: Pasanen, Anu
name: Määttä, Tomi A.
name: Huusko, Johanna M.
name: Ohlmeier, Steffen
name: Bergmann, Ulrich
name: Ojaniemi, Marja
name: Muglia, Louis J.
name: Hallman, Mikko
name: Rämet, Mika
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 1: FigS1. Representative 2D gel of human placental tissue after spontaneous preterm birth. FigS2. Densitometric evaluation of western blot of alpha-1 antitrypsin and tubulin α-1B. FigS3. Proteomic differences between chorionic and basal plates of the placenta. FigS4. Immunoelectron microscopy images of localization of AAT and fibronectin in spontaneous term birth placenta. FigS5. Colocalization fluorescence image of AAT and Rab7, and AAT and CD63. FigS6. mRNA expression levels after gene knockdown of SERPINA1. FigS7. Gene expression changes after SERPINA1 silencing according to RNA sequencing and qPCR. TableS1. Protein levels and statistical significance in comparisons of spontaneous preterm and term birth. TableS2. Protein levels and statistical significance in comparisons of spontaneous and elective preterm birth. TableS3. Protein identification. TableS4. Upregulated genes after SERPINA1 silencing in HTR8/SVneo cells. TableS5. Downregulated genes after SERPINA1 silencing in HTR8/SVneo cells. TableS6. Biological pathways affected by SERPINA1 silencing in HTR8/SVneo cells. TableS7. Gene Ontology Biological Processes (GO-BP) term enrichment analysis of genes affected by SERPINA1 silencing. TableS8. Gene Ontology Cellular Component (GO-CC) term enrichment analysis of genes affected by SERPINA1 silencing. TableS9. Comparison of RNA sequencing and qRT-PCR of genes affected by SERPINA1 knockdown.
Megahertz single-particle imaging at the European XFEL
Creators: name: Sobolev, Egor
name: Zolotarev, Sergei
name: Giewekemeyer, Klaus
name: Bielecki, Johan
name: Okamoto, Kenta
name: Reddy, Hemanth K. N.
name: Andreasson, Jakob
name: Ayyer, Kartik
name: Barak, Imrich
name: Bari, Sadia
name: Barty, Anton
name: Bean, Richard
name: Bobkov, Sergey
name: Chapman, Henry N.
name: Chojnowski, Grzegorz
name: Daurer, Benedikt J.
name: Dörner, Katerina
name: Ekeberg, Tomas
name: Flückiger, Leonie
name: Galzitskaya, Oxana
name: Gelisio, Luca
name: Hauf, Steffen
name: Hogue, Brenda G.
name: Horke, Daniel A.
name: Hosseinizadeh, Ahmad
name: Ilyin, Vyacheslav
name: Jung, Chulho
name: Kim, Chan
name: Kim, Yoonhee
name: Kirian, Richard A.
name: Kirkwood, Henry
name: Kulyk, Olena
name: Küpper, Jochen
name: Letrun, Romain
name: Loh, N. Duane
name: Lorenzen, Kristina
name: Messerschmidt, Marc
name: Mühlig, Kerstin
name: Ourmazd, Abbas
name: Raab, Natascha
name: Rode, Andrei V.
name: Rose, Max
name: Round, Adam
name: Sato, Takushi
name: Schubert, Robin
name: Schwander, Peter
name: Sellberg, Jonas A.
name: Sikorski, Marcin
name: Silenzi, Alessandro
name: Song, Changyong
name: Spence, John C. H.
name: Stern, Stephan
name: Sztuk-Dambietz, Jolanta
name: Teslyuk, Anthon
name: Timneanu, Nicusor
name: Trebbin, Martin
name: Uetrecht, Charlotte
name: Weinhausen, Britta
name: Williams, Garth J.
name: Xavier, P. Lourdu
name: Xu, Chen
name: Vartanyants, Ivan A.
name: Lamzin, Victor S.
name: Mancuso, Adrian
name: Maia, Filipe R. N. C.
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2020
Subjects: subject: 530

description: The emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by superconducting accelerator technology enables the measurement of significantly more experimental data per day than was previously possible. The European XFEL will soon provide 27,000 pulses per second, more than two orders of magnitude more than any other XFEL. The increased pulse rate is a key enabling factor for single-particle X-ray diffractive imaging, which relies on averaging the weak diffraction signal from single biological particles. Taking full advantage of this new capability requires that all experimental steps, from sample preparation and delivery to the acquisition of diffraction patterns, are compatible with the increased pulse repetition rate. Here, we show that single-particle imaging can be performed using X-ray pulses at megahertz repetition rates. The obtained results pave the way towards exploiting high repetition-rate X-ray free-electron lasers for single-particle imaging at their full repetition rate.
Characterizing land-use change over space and time: applying principal components analysis in the Brazilian Legal Amazon
Creators: name: Bell, Andrew R.
name: Caviglia-Harris, Jill L.
name: Cak, Anthony D.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: Plant Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology

description: We apply a principal component analysis to characterize the dimensions of spatio-temporal change in agriculture within the Brazilian Legal Amazon for the period 1996–2006. Around 80% of spatio-temporal variation across a broad set of descriptors could be explained by four trajectories well observed in the region: large-scale ranching, inactive forested property, small-scale farming, and mechanized agriculture. Spatial clustering based on these trajectories reveals a shift in the characteristics of the agricultural frontier, and provides quantitative method for distinguishing functional sub-regions previously suggested in the literature. Our analysis suggests a marked growth in agriculture over the decade between 1996 and 2006, with agricultural development encroaching toward the interior of the Brazilian Amazon not only from the south and southeast, but also from the west.
Natural anti-A and Tn-cross-reactive IgM arise from developmental O-GalNAc glycosylations.*
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Developmental Biology
subject: Zoology
subject: 60114 Systems Biology
subject: Structural Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics

description: While native blood group A-like glycans have not been demonstrated in prokaryotic microorganisms as a source of the human “natural” anti-A/B isoagglutinin production and the trans-species, vertebrate O-GalNAc-Ser/Thr glycosylations do not occur in bacteria, the O-GalNAc glycan-bearing ovarian glycolipids, discovered in C57BL/10 mice, are complementary to the syngeneic anti-A-reactive immunoglobulin M (IgM), which does not appear in animals that underwent ovariectomy prior to the onset of puberty. This murine anti-A “auto” antibody and the human innate anti-A isoagglutinin show identical serological reaction patterns. In mouse and man, this antibody molecule most likely obtains its complementarity from the early trans-species O-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion, which completes the cell differentiation processes and results in the release of characteristic O-glycan-depleted plasma proteins, such as the secretory IgM that might reveal the structure of the volatilely expressed, “lost” glycan through germline-specific serine residues. Consequently, the early or first O-GalNAc glycosylations of proteins appear metabolically related to those of the mucin-type, “aberrant” monosaccharide GalNAcα1-O-Ser/Thr-R also referred to the Tn antigen and explain the anti-Tn cross-reactivity of anti-A-specific immunoglobulins and the pronounced occurrence of cross-reactive anti-Tn antibody in plasma from humans of histo (blood) group O. In fact, in the human blood group O, an A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur, impacting the levels of the anti-Tn antibody, which may function as a growth regulator that depending on its levels, may initiate a complex process of growth inhibition through enzyme-substrate competition with subsequent trans-species O-GalNAc-glycosylations.
Additional file 1 of Greater than the sum of the parts: a qualitative content analysis of what constitutes a good treatment in the inpatient setting
Creators: name: Locher, Cosima
name: Buergler, Sarah
name: Heimgartner, Nadja
name: Koechlin, Helen
name: Gerger, Heike
name: Gaab, Jens
name: Büchi, Stefan
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1: eFigure 1. Inductive development of categories according to Mayring. eTable 1. Superordinate categories, main categories and categories.
Climatic and socio-economic factors determine the level of invasion by alien plants in Chile
Creators: name: Fuentes, Nicol
name: Saldaña, Alfredo
name: Kühn, Ingolf
name: Klotz, Stefan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Evolutionary Biology

description: Background: Economic activities are substantial factors in alien plant establishment and invasions. Climate also plays an important role in the distribution of alien species.Aims: We evaluate the relationship between alien species density and both climatic and socio-economic factors at the scale of provinces located in a latitudinal-bioclimatic gradient in Chile.Methods: We used generalised linear models with backward selection to evaluate the relative importance of each parameter (human population, gross domestic product, length of traffic routes, crop cover, abandoned crop cover, artificial plantations, protected areas, annual rainfall and temperature) on species density. We compared the average species density among climate types.Results: Alien density was higher for provinces located in the most populated areas with Mediterranean and temperate oceanic climates (south-central Chile) and decreased for less populated provinces in the north and the southernmost parts (desert and sub-Antarctic wetlands). Human population, length of traffic routes and annual rainfall significantly explained the variation in alien species density in Chile.Conclusions: Although human population still increases, the results can be used especially in high priority conservation areas where traffic routes and human settlements can be objectively reduced or managed, to reduce the potential increase in the number of alien species.
Inteligencia Artificial en Salud: Innovación en Soporte Profesional, Asistencia y Toma de Decisiones
Creators: name: Barrera-Linares, Ernesto
Publisher: name: Zenodo
Year: 2024
Subjects: Inteligencia Artificial Generativa
ChatGPT
IA
Formación Continua Sanitaria
Farmacia Hospitalaria
Farmacia de Atención Primaria
IA Generativa
Farmacia Clínica
Innovación en Salud

description: Presentación utilizada por el autor en el Diploma Universitario de Especialización en Farmacia Clínica y Gestión Farmacéutica | Universidad de Granada 

Disponible online en la Web  Inteligencia Artificial en Salud: Innovación en Soporte Profesional, Asistencia y Toma de Decisiones
HIV AND AIDS: PREJUDICE, DISCRIMINATION AND STIGMA AT WORK
Creators: name: Luiz Eduardo Gunther
name: EDUARDO MILLÉO BARACAT
Publisher: name: figshare
Year: 2014
Subjects: subject: Law
subject: FOS: Law

description: One can not speak about HIV / AIDS without dissociating them from the words discrimination, prejudice and stigma. As to when the act was discriminatory, now seems no more doubts, in the workplace, which discriminatory practices can occur "on admission in the course of employment and dismissal, when configured offense to the dignity of the worker and the principle of equality.” The prohibition of discrimination is a constitutional guarantee, but it is not considered as discrimination factor the health status and currently this kind of discrimination exists in labor relations. Do not insist enough on the assertion that the employees excluded from the labor market support two kinds of disease, one of the prejudice with which they are treated. These employees thus become stigmatized, supporting a "systematic differential treatment", making it "doubly victimized, both by the illness that affects, as the discrimination facing them. " However, the Recommendation No. 200 of the ILO approved there must be human rights guarantees to holders of HIV and AIDS, to their workplace, prohibiting discrimination and stigmatization.
Natural anti-A and Tn-cross-reactive IgM arise from developmental O-GalNAc glycosylations.*
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Developmental Biology
subject: Zoology
subject: 60114 Systems Biology
subject: Structural Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics

description: While native blood group A-like glycans have not been demonstrated in prokaryotic microorganisms as a source of the human “natural” anti-A/B isoagglutinin production and the trans-species, vertebrate O-GalNAc-Ser/Thr glycosylations do not occur in bacteria, the O-GalNAc glycan-bearing ovarian glycolipids, discovered in C57BL/10 mice, are complementary to the syngeneic anti-A-reactive immunoglobulin M (IgM), which does not appear in animals that underwent ovariectomy prior to the onset of puberty. This murine anti-A “auto” antibody and the human innate anti-A isoagglutinin show identical serological reaction patterns. In mouse and man, this antibody molecule most likely obtains its complementarity from the early trans-species O-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion, which completes the cell differentiation processes and results in the release of characteristic O-glycan-depleted, complementary proteins, such as the secretory IgM that might reveal the structure of the volatilely expressed, “lost” glycan through germline-specific serine residues. Consequently, the early or first O-GalNAc glycosylations of proteins appear metabolically related to those of the mucin-type, “aberrant” monosaccharide GalNAcα1-O-Ser/Thr-R also referred to the Tn antigen and explain the anti-Tn cross-reactivity of anti-A-specific immunoglobulins and the pronounced occurrence of cross-reactive anti-Tn antibody in plasma from humans of histo (blood) group O. In fact, in the human blood group O, an A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur, impacting the levels of the anti-Tn antibody, which may function as a growth regulator that depending on its levels, may initiate a complex process of growth inhibition through enzyme-substrate competition with subsequent trans-species O-GalNAc-glycosylations.
К ВОПРОСУ О «ГРАЖДАНСТВЕННОСТИ» МУЗЫКАЛЬНОГО КЛАССИЦИЗМА
Creators: name: Рыбинцева Галина Валериановна
Publisher: name: Южно-Российский музыкальный альманах
Year: 2020
Subjects: музыка
классицизм
гражданственность
социум
музыкальный жанр
жанровый тематизм.

description: Наиболее значимым качеством произведений классицизма является их «гражданственное звучание», которое обеспечивается преобладанием идеи ответственности человека перед обществом и государством и акцентированием социального статуса художественных образов. Данному требованию полностью соответствуют памятники литературы, изобразительного искусства, архитектуры XVII–XVIII столетий. В то же время возникает вопрос: каким образом обеспечивается гражданственное звучание обобщенных образов непрограммных инструментальных произведений западноевропейского музыкального классицизма? Признанным средством, позволяющим решать названную задачу, является жанровый характер музыкального тематизма, то есть использование для характеристики образа характерных черт определенного бытового (или народно-бытового) жанра. Жанр, как явление по природе своей социальное, имеет в общественном сознании прочные ассоциативные связи с условиями и средствами его исполнения, а потому является носителем информации о времени и месте своего бытования. Жанр характеризует конкретную социальную общность людей и имеет возможность объединять людей, способствовать их сплочению в коллектив. Поэтому свойственный образцам венского классицизма жанровый характер тематизма «поднимает» героя музыкального произведения и его «деяния» до социального уровня. Такой герой не руководствуется личными интересами, а действует во благо общества, государства или же человечества в целом. Традиция использования в профессиональной музыке бытовых жанров и их характерных черт берет начало в искусстве классицизма, что по времени соответствует появлению социально-политических учений, объясняющих происхождение, сущность и функции государства. Такая аналогия еще раз указывает на жанр как средство социализации образа, события, ситуации, которое позволяет сообщать произведениям музыкального классицизма высокое гражданственное звучание.
РУССКИЙ МУЗЫКАЛЬНЫЙ АРИСТОТЕЛИЗМ: «САД РАДОСТИ И ПЕЧАЛИ» С. А. ГУБАЙДУЛИНОЙ В СВЕТЕ СЕМИОТИКИ М. И. ЛЕКОМЦЕВОЙ
Creators: name: Марков Александр Викторович
Publisher: name: Южно-Российский музыкальный альманах
Year: 2020
Subjects: Аристотель
C. Губайдулина
М. Лекомцева
топика
рецитация
кода
символ
семиотика
Тартуско-московская семиотическая школа

description: Хотя «Сад радости и печали» относится к самым известным произведениям С. А. Губайдулиной, функция речитативной коды и ее общий смысл не вполне ясны. В данной статье доказывается, что данное произведение Губайдулиной относится к своеобразному русскому аристотелизму, интерпретации «золотой середины», который сам нуждается в реконструкции как интеллектуальное течение. Подробно анализируются особенности такого аристотелизма на примере исследований М. И. Лекомцевой – одного из видных представителей Тартуско-московской семиотической школы, до сих пор остающегося в тени ее основателей. При всем своем рационализме, Тартуско-московская школа исходила из соединения учения Платона о форме как выражении с учением Канта о границах разума, при этом Аристотель оставался в стороне. Лекомцева не просто обратилась к философскому и риторическому наследию Аристотеля для отдельных интерпретаций поэтики, но разработала оригинальную трактовку учения Аристотеля о топосе, «пересобрав» аристотелианство. Эта «пересборка» резко порвала с привычным образом Аристотеля как энциклопедиста, создателя различных наук и вписала его в контекст модернистской поэзии и модернистской музыки, где поэтика, риторика, логика и топика могут исходить из одних интуиций или обобщенных символов, таких как «граница», «пересечение границы», «область», «сад» и другие. Изучение работ Лекомцевой, дающей оригинальное истолкование языковых явлений на основании аристотелизма, позволяет уточнить смысл частей произведения Губайдулиной. В статье также доказывается, что главным сюжетом произведения является недостаточность эвристического понимания бинарных оппозиций и поэтических образов модернизма, необходимость преодолеть высокий модернизм ради более прямого высказывания, что может быть осуществлено благодаря новому прочтению «золотой середины» Аристотеля не как посредничества между оппозициями, но как провокации, направленной на утверждение нового статуса и понимания творчества.