cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(502449) Alexander Wilson Paterson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Evaluation of Predictive Data Mining Algorithms in Erythemato-Squamous Disease Diagnosis
Creators: name: Danjuma, Kwetishe
name: Osofisan, Adenike O.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Machine Learning (cs.LG)
subject: Computational Engineering, Finance, and Science (cs.CE)
subject: FOS: Computer and information sciences

description: A lot of time is spent searching for the most performing data mining algorithms applied in clinical diagnosis. The study set out to identify the most performing predictive data mining algorithms applied in the diagnosis of Erythemato-squamous diseases. The study used Naive Bayes, Multilayer Perceptron and J48 decision tree induction to build predictive data mining models on 366 instances of Erythemato-squamous diseases datasets. Also, 10-fold cross-validation and sets of performance metrics were used to evaluate the baseline predictive performance of the classifiers. The comparative analysis shows that the Naive Bayes performed best with accuracy of 97.4%, Multilayer Perceptron came out second with accuracy of 96.6%, and J48 came out the worst with accuracy of 93.5%. The evaluation of these classifiers on clinical datasets, gave an insight into the predictive ability of different data mining algorithms applicable in clinical diagnosis especially in the diagnosis of Erythemato-squamous diseases.
description: 10 pages, 3 figures 2 tables
Additional file 4 of Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease
Creators: name: Barthelson, Karissa
name: Pederson, Stephen Martin
name: Newman, Morgan
name: Lardelli, Michael
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4: Principal component analysis. a Plot of principal component 1 (PC1) against PC2 from a principle component analysis (PCA) of the logCPMs from each sample. b PC1 against the library size per sample. The linear relationship observed between PC1 and library size suggests that the largest source of variability in this dataset is due to library size. c PC1 against the W_1 covariate from RUVseq. A linear relationship between PC1 and W_1 is observed. d W_1 against library size. e PC1 against PC2 after removal of 1 factor of unwanted variation using RUVSeq [38]. f PC1 no longer depends on library size after RUVSeq transformation.
Passive sensing of low velocity impact damage on composite panels in simulated environmental and operational conditions
Creators: name: Hami Seno, Aldyandra
Publisher: name: Imperial College London
Year: 2021

description: During its lifetime, an aircraft structure is subjected to impacts from a wide range of sources (e.g. bird strike, tool drop, hail). For composite structures, low velocity impacts may generate Barely Visual Impact Damage (BVID) that is difficult to assess without complex inspection techniques and may significantly reduce the strength of the structure. To reduce the need for costly inspection techniques, there is interest in developing integrated Structural Health Monitoring (SHM) systems to monitor the occurrence of impacts and provide location and severity estimations to allow the operators to make maintenance decisions (e.g. repairs). Many methods have been developed to achieve this using information encoded in impact induced strain waves recorded by sensors attached to the structure. However, these so-called passive methods have mostly been developed in laboratory conditions and do not consider operational and environmental in-service conditions which may significantly influence the accuracy and feasibility of these estimates. The research reported in this thesis was conducted to address some of the main challenges associated of with passive SHM application for in-service conditions, specifically accuracy, robustness, reliability and feasibility. A data driven approach was taken as it allows flexibility in scaling up from simple coupons to complex structures. Novel signal processing and reference database methods were proposed for accurate and robust impact location and maximum impact force estimation which only requires data from a single reference impact case, making it feasible for the variable conditions in service. A novel kriging based extension to these methods was developed to allow uncertainty quantification that provides more reliable information to the operator. A multifidelity approach to constructing the reference database for the data driven approach was also developed to significantly reduce the requirement of experimental sampling with alternative data sources and increase feasibility. Lastly, the developed methods were tested on prototype data acquisition units to demonstrate applicability on in-service hardware. The results of this thesis have provided novel improvements to the data driven passive SHM approach which significantly increases its applicability for aircraft structures.
Additional file 7 of Feeding, caregiving practices, and developmental delay among children under five in lowland Nepal: a community-based cross-sectional survey
Creators: name: Dulal, Sophiya
name: Prost, Audrey
name: Karki, Surendra
name: Merom, Dafna
name: Shrestha, Bhim Prasad
name: Bhandari, Bishnu
name: Manandhar, Dharma S.
name: Osrin, David
name: Costello, Anthony
name: Saville, Naomi M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 7: Supplementary Table 18. Matrix summarising the multivariable analysis in the Model 3 for each indicator*.
(502427) Albina [Burndred]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Overcoming product inhibition in catalysis of the intramolecular Schmidt reaction
Creators: name: Motiwala, H.F.
name: Porubsky, P.
name: Li, S.-W.
name: Fehl, C.
name: Hirt, E.
name: Aubé, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: A method for carrying out the intramolecular Schmidt reaction of alkyl azides and ketones using a substoichiometric amount of catalyst is reported. Following extensive screening, the use of the strong hydrogen-bond-donating solvent hexafluoro-2-propanol was found to be consistent with low catalyst loadings, which ranged from 2.5 mol % for favorable substrates to 25 mol % for more difficult cases. Reaction optimization, broad substrate scope, and preliminary mechanistic studies of this improved version of the reaction are described.
On the uniqueness of $L_p$-Minkowski problems: the constant $p$-curvature case in $\mathbb{R}^3$
Creators: name: Huang, Yong
name: Liu, Jiakun
name: Xu, Lu
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: We study the $C^4$ smooth convex bodies $\mathbb{K}\subset\mathbb{R}^{n+1}$ satisfying $K(x)=u(x)^{1-p}$, where $x\in\mathbb{S}^n$, $K$ is the Gauss curvature of $\partial\mathbb{K}$, $u$ is the support function of $\mathbb{K}$, and $p$ is a constant. In the case of $n=2$, either when $p\in[-1,0]$ or when $p\in(0,1)$ in addition to a pinching condition, we show that $\mathbb{K}$ must be the unit ball. This partially answers a conjecture of Lutwak, Yang, and Zhang about the uniqueness of the $L_p$-Minkowski problem in $\mathbb{R}^3$. Moreover, we give an explicit pinching constant depending only on $p$ when $p\in(0,1)$.
description: references updated
FRAMMENTI. L’USO DELLE RISORSE PER LA CASA ALPINA: IL RILEVAMENTO COME CONOSCENZA
Creators: name: Donelli, Andrea
Publisher: name: BDC. Bollettino Del Centro Calza Bini
Year: 2019

description: I frammenti appartengono alla tradizione di una comunità, di una società di montagna che rimasta pressoché stanziale, che nell’ampio arco di tempo relativo alla sua esistenza ed esperienza ha provveduto alla messa a punto di una serie di fatti relativi alla propria sussistenza che sono divenuti quotidiani e feriali. Questioni geografiche, orografiche, costruttive hanno generato una forma di economia determinata da un uso sapiente delle risorse, uso e non consumo di esse. La lezione che deriva da questo mondo e modo di agire è che non è mai stato concepito lo spreco. Da questo insegnamento deriva e se ne deduce un processo conoscitivo in grado di spiegare alcune delle ragioni della vita appartenente a questa forma creativa “dell’antica società” di montagna. Parole chiave: architettura vernacolare, disegni e indagini, uso delle risorse
description: BDC. Bollettino Del Centro Calza Bini, Vol 19 No 1 (2019): The Circular Economy Model: from the Building Functional Reuse to the Urban System Regeneration
A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry
Creators: name: Garcia, M.J.
name: Ivnitski-Steele, I.
name: Li, K.
name: Oprea, T.I.
name: Perez, D.
name: Yao, T.
name: Bologa, C.G.
name: Strouse, J.J.
name: Carter, M.B.
name: Gouveia, K.
name: Schroeder, C.E.
name: Edwards, B.S.
name: Chavez, S.E.
name: Salas, V.M.
name: Ursu, O.
name: Young, S.M.
name: Tegos, G.P.
name: Weiner, W.S.
name: Sklar, L.A.
name: Maki, B.E.
name: Khawaja, H.M.
name: Aubé, J.
name: Waller, A.
name: Larson, R.S.
name: Ricci, J.
name: Foutz, T.D.
name: Golden, J.E.
name: Simpson, D.S.
name: Evangelisti, A.M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Chemotherapeutics tumor resistance is a principal reason for treatment failure, and clinical and experimental data indicate that multidrug transporters such as ATP-binding cassette (ABC) B1 and ABCG2 play a leading role by preventing cytotoxic intracellular drug concentrations. Functional efflux inhibition of existing chemotherapeutics by these pumps continues to present a promising approach for treatment. A contributing factor to the failure of existing inhibitors in clinical applications is limited understanding of specific substrate/inhibitor/pump interactions. We have identified selective efflux inhibitors by profiling multiple ABC transporters against a library of small molecules to find molecular probes to further explore such interactions. In our primary screening protocol using JC-1 as a dual-pump fluorescent reporter substrate, we identified a piperazine-substituted pyrazolo[1,5-a]pyrimidine substructure with promise for selective efflux inhibition. As a result of a focused structure-activity relationship (SAR)-driven chemistry effort, we describe compound 1 (CID44640177), an efflux inhibitor with selectivity toward ABCG2 over ABCB1. Compound 1 is also shown to potentiate the activity of mitoxantrone in vitro as well as preliminarily in vivo in an ABCG2-overexpressing tumor model. At least two analogues significantly reduce tumor size in combination with the chemotherapeutic topotecan. To our knowledge, low nanomolar chemoreversal activity coupled with direct evidence of efflux inhibition for ABCG2 is unprecedented.
URBAN METABOLISM AND CIRCULAR ECONOMY INTERRELATIONS. ANALYSING THREE EXAMPLES OF EU-FUNDED PROJECTS
Creators: name: Amenta, Libera
name: Lucertini, Giulia
Publisher: name: Bulletin of the Calza Bini Center
Year: 2019

description: In Europe, the concepts of urban metabolism (UM) and circular economy (CE) have been made operational in several research projects and practical applications. However, although in the last years policy interests and scientific literature about UM and CE have been growing significantly, these concepts remain open, and their applicability is not univocal, especially concerning CE applied in urban systems. This paper analyses how three EU funded projects developed the interrelations amongst the fields of UM and CE. Different dimensions and scales of circularity were investigated, namely: (i) the potentials to create networking among different sectors to recycle waste at the regional scale; (ii) the importance of regenerating wastescapes; (iii) the accounting of resource flows that compose UM; (iv) the direct involvement of stakeholders in the management of resources. Keywords: circular economy, urban metabolism, regenerative city
description: Bulletin of the Calza Bini Center, Vol 19 No 1 (2019): The Circular Economy Model: from the Building Functional Reuse to the Urban System Regeneration
(502436) Robert Hogg
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
COMMUNITY-LED PROCESSES FOR PERI-URBAN REGENERATION IN NAPLES: EVALUATING SCENARIOS OF SOCIAL SELF-ORGANISATION AND COOPERATION
Creators: name: Cerreta, Maria
name: Reitano, Maria
Publisher: name: Bulletin of the Calza Bini Center
Year: 2019

description: The research investigates the possibility for regenerative socio-spatial dynamics to be activated within peri-urban areas, through community engagement in transformation and cooperative processes, promoting environmental integrity and socio-spatial diversity. This contribution aims at evaluating different scenarios involving social self-organisation, towards the activation of community-led regeneration processes within peri-urban residual spaces. Through a site-specific set of indicators, related to categories of territorial and social self-production, the preferable scenario is evaluated, adopting the Analytic Network Process (ANP) as Multi-Criteria Decision Aid method (MCDA). Keywords: residual space, social self-organisation, peri-urban regeneration, Analytic Network Process (ANP)
description: Bulletin of the Calza Bini Center, Vol 19 No 1 (2019): The Circular Economy Model: from the Building Functional Reuse to the Urban System Regeneration
Development of functionally selective, small molecule agonists at kappa opioid receptors
Creators: name: Prisinzano, T.E.
name: Zhou, L.
name: Bohn, L.M.
name: Lovell, K.M.
name: Schmid, C.L.
name: Slauson, S.R.
name: Hodde, P.
name: Aubé, J.
name: Streicher, J.M.
name: Phillips, A.M.
name: Stahl, E.
name: Frankowski, K.J.
name: Cameron, M.D.
name: Madoux, F.
Publisher: name: American Society for Biochemistry and Molecular Biology Inc.
Year: 2013

description: The kappa opioid receptor (KOR) is widely expressed in the CNS and can serve as a means to modulate pain perception, stress responses, and affective reward states. Therefore, the KOR has become a prominent drug discovery target toward treating pain, depression, and drug addiction. Agonists at KOR can promote G protein coupling and βarrestin2 recruitment as well as multiple downstream signaling pathways, including ERK1/2 MAPK activation. It has been suggested that the physiological effects ofKORactivation result from different signaling cascades, with analgesia being G protein-mediated and dysphoria being mediated through βarrestin2 recruitment. Dysphoria associated with KOR activation limits the therapeutic potential in the use of KOR agonists as analgesics; therefore, it may be beneficial to develop KOR agonists that are biased toward G protein coupling and away from βarrestin2 recruitment. Here, we describe two classes of biased KOR agonists that potently activateGprotein coupling but weakly recruitβarrestin2. These potent and functionally selective small molecule compounds may prove to be useful tools for refining the therapeutic potential of KOR-directed signaling in vivo.
LABORATORIO PONTICELLI. TRE SCENARI PER UN PROGETTO DI RECUPERO DI PAESAGGI INTERROTTI
Creators: name: Attademo, Anna
name: Castigliano, Marica
name: Errico, Maria Gabriella
Publisher: name: BDC. Bollettino Del Centro Calza Bini
Year: 2019

description: Il caso studio del quartiere di Ponticelli, nella periferia orientale di Napoli, offre un repertorio di aree inedificate, frammiste ad edilizia residenziale pubblica, grandi attrezzature e reti infrastrutturali. Decenni di pianificazione onnicomprensiva hanno composto un panorama di paesaggi di scarto e disattesi dei piani. Nella loro sovrapposizione al fuori-scala di uno spazio urbano senza qualità, nasce un’inedita possibilità per recuperare i rapporti con il palinsesto agricolo, in processi di rigenerazione incrementale, entro cui coinvolgere nuovi attori, misurare gerarchie tra spazio aperto e costruito. Il Laboratorio di Sintesi del Corso di Studi UPTA (DiARC, Unina), sullo sfondo dei principi dello sviluppo sostenibile, ipotizza tre scenari per orientare il nuovo Programma di Recupero Urbano recentemente promosso dal Comune di Napoli. Parole chiave: processo, attori, agricoltura urbana.
description: BDC. Bollettino Del Centro Calza Bini, Vol 19 No 1 (2019): The Circular Economy Model: from the Building Functional Reuse to the Urban System Regeneration
Additional file 1 of System dynamics modelling to engage community stakeholders in addressing water and sugar sweetened beverage consumption
Creators: name: Brown, Andrew D.
name: Bolton, Kristy A.
name: Clarke, Brydie
name: Fraser, Penny
name: Lowe, Janette
name: Kays, Jake
name: Hovmand, Peter S.
name: Allender, Steven
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. Model equations. A full listing of the equations of the system dynamics model built with stakeholders.
Electronic structure of Mott-insulator CaCu3Ti4O12: Photoemission and inverse photoemission study
Creators: name: Im, H. J.
name: Iwataki, M.
name: Yamazaki, S.
name: Usui, T.
name: Adachi, S.
name: Tsunekawa, M.
name: Watanabe, T.
name: Takegahara, K.
name: Kimura, S.
name: Matsunami, M.
name: Sato, H.
name: Namatame, H.
name: Taniguchi, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We have performed the photoemission and inverse photoemission experiments to elucidate the origin of Mott insulating states in A-site ordered perovskite CaCu$_3$Ti$_4$O$_{12}$ (CCTO). Experimental results have revealed that Cu 3$d$-O 2$p$ hybridized bands, which are located around the Fermi level in the prediction of the local-density approximation (LDA) band calculations, are actually separated into the upper Hubbard band at $\sim$ 1.5 eV and the lower Hubbard band at $\sim$ $-$1.7 eV with a band gap of $\sim$ 1.5-1.8 eV. We also observed that Cu 3$d$ peak at $\sim$ $-$3.8 eV and Ti 3$d$ peak at $\sim$ 3.8 eV are further away from each other than as indicated in the LDA calculations. In addition, it is found that the multiplet strucutre around $-$9 eV includes a considerable number of O 2$p$ states. These observations indicate that the Cu 3$d$ and Ti 3$d$ electrons hybridized with the O 2$p$ states are strongly correlated, which originates in the Mott-insulating states of CCTO.
description: 11 pages, 3 figures
Additional file 1 of Predictors for adoption of e-learning among health professional students during the COVID-19 lockdown in a private university in Uganda
Creators: name: Komuhangi, Alimah
name: Mpirirwe, Hilda
name: Robert, Lubanga
name: Githinji, Florence Wamuyu
name: Nanyonga, Rose Clarke
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
Additional file 6 of Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease
Creators: name: Barthelson, Karissa
name: Pederson, Stephen Martin
name: Newman, Morgan
name: Lardelli, Michael
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 6: Results of enrichment testing. Results of the individual enrichment testing algorithms (fry, camera and fgsea).
A LITERATURE REVIEW ABOUT LIFE CYCLE ASSESSMENT AS A TOOL TO SUPPORT CIRCULAR ECONOMY INNOVATION IN THE BUILT ENVIRONMENT SECTOR
Creators: name: Angrisano, Mariarosaria
name: Fusco Girard, Luigi
name: Bianchi, Alessandro
Publisher: name: Bulletin of the Calza Bini Center
Year: 2019

description: The built environment sector contributes to climate change for different reasons. First of all, to realize a building and for its maintenance, several natural resources and materials are required. There is the necessity of great energy quantities for the realization of a building. The built environment sector is responsible of a good percentage of greenhouse gas emissions, in terms of “operational emissions” and “embodied emission”. The aim of this article is to analyse how the circular economy is able to support the buildings sustainable design and what are the evaluation tools to sustain this activity. In this scenario, an analysis of the reference literature about the Life Cycle Assessment was proposed, to understand what are the new research fields in which this tool is tested. Keywords: circular economy, built environment sector, Life Cycle Assessment
description: Bulletin of the Calza Bini Center, Vol 19 No 1 (2019): The Circular Economy Model: from the Building Functional Reuse to the Urban System Regeneration
(502425) Thomas Howard
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
PLANNING THE CIRCULAR CITY: FOCUS ON BUILDINGS’ ENVIRONMENTAL IMPACT
Creators: name: Foster, Gillian
Publisher: name: Bulletin of the Calza Bini Center
Year: 2019

description: Circular City initiatives to implement circular economy goals are expanding in Europe. This article provides the nascent Circular City movement with a rationale and motivation to target existing buildings and cultural heritage buildings. The article argues that Circular City initiatives should aim to achieve low-carbon development; less construction and demolition wastes; improving energy efficiency; and improving resource efficiency in the buildings sector in line with European Union policy goals. Keywords: Circular City, buildings, historic buildings, environment, Europe
description: Bulletin of the Calza Bini Center, Vol 19 No 1 (2019): The Circular Economy Model: from the Building Functional Reuse to the Urban System Regeneration
Additional file 8 of Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease
Creators: name: Barthelson, Karissa
name: Pederson, Stephen Martin
name: Newman, Morgan
name: Lardelli, Michael
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 8: Changes to gene expression in young-adult zebrafish brain transcriptomes are likely not due to altered cell type proportions. We obtained representative expression markers of neurons (72 genes), oligodendrocytes (100 genes) and astrocytes (44 genes) from [53] and representative expression markers of microglia (533 genes) from [54]. The logCPM distributions for these marker genes in each of the samples are similar, supporting that, broadly, the distribution of these cell types is consistent between samples. Data are shown as violin plots, displaying the kernel probability density of the logCPMs, overlaid with boxplots, showing summary statistics, and coloured by genotype.
Characterization of a Cdc42 protein inhibitor and its use as a molecular probe
Creators: name: Chigaev, A.
name: Hudson, L.G.
name: Simpson, D.
name: Swanson, S.
name: Hjelle, B.
name: Ursu, O.
name: Waller, A.
name: Buranda, T.
name: Phillips, G.K.
name: Golden, J.E.
name: Romero, E.
name: Nöth, J.
name: Carter, M.
name: Oprea, T.
name: Schroeder, C.E.
name: Sklar, L.A.
name: Kenney, S.R.
name: Strouse, J.J.
name: Wandinger-Ness, A.
name: Hong, L.
name: Aubé, J.
Publisher: name: American Society for Biochemistry and Molecular Biology Inc.
Year: 2013

description: Cdc42 plays important roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. Overactive Cdc42 has been implicated in the pathology of cancers, immune diseases, and neuronal disorders. Therefore, Cdc42 inhibitors would be useful in probing molecular pathways and could have therapeutic potential. Previous inhibitors have lacked selectivity and trended toward toxicity. We report here the characterization of a Cdc42-selective guanine nucleotide binding lead inhibitor that was identified by high throughput screening. A second active analog was identified via structure-activity relationship studies. The compounds demonstrated excellent selectivity with no inhibition toward Rho and Rac in the same GTPase family. Biochemical characterization showed that the compounds act as noncompetitive allosteric inhibitors. When tested in cellular assays, the lead compound inhibited Cdc42-related filopodia formation and cell migration. The lead compound was also used to clarify the involvement of Cdc42 in the Sin Nombre virus internalization and the signaling pathway of integrin VLA-4. Together, these data present the characterization of a novel Cdc42-selective allosteric inhibitor and a related analog, the use of which will facilitate drug development targeting Cdc42-related diseases and molecular pathway studies that involve GTPases.
(502437) Robert Shuckburgh
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
ADAPTIVE REUSE AND REHABILITATION OF CULTURAL HERITAGE. A PERFORMANCE-BASED APPROACH FOR FIRE SAFETY
Creators: name: De Medici, Stefania
name: Bellomia, Martina
name: Senia, Carla
Publisher: name: Bulletin of the Calza Bini Center
Year: 2019

description: The international debate on sustainable development and the growing need to find new directions for the closure of loops includes architectural issues. The countless abandoned building resources as well as buildings in advanced state of decay highlight the urgent need to extend the life cycle of the building heritage, helping the trade-off between users’ needs and past performance. The use of tools and methodologies for the simulation of different intervention scenarios allows reducing the resources needed to design and perform adaptations of existing buildings to new needs. The paper introduces an example of Fire Safety Engineering (FSE) performance-based approach applied to the rehabilitation of abandoned listed heritage buildings, of the Teatro della Concordia in Ragusa, Sicily. The findings are easy to put into practice, allowing the FSE performance approach to be used at an early stage of the design process. Keywords: Adaptive Reuse, Performance-Based Design, Fire Safety Engineering
description: Bulletin of the Calza Bini Center, Vol 19 No 1 (2019): The Circular Economy Model: from the Building Functional Reuse to the Urban System Regeneration
LA CONOSCENZA STORICA PER LA VALUTAZIONE DELLE VULNERABILITÀ DEL PATRIMONIO CULTURALE ECCLESIASTICO: UN APPROCCIO SISTEMICO PER STRATEGIE DI VALORIZZAZIONE E RIGENERAZIONE
Creators: name: De Lucia, Giulia
Publisher: name: BDC. Bollettino Del Centro Calza Bini
Year: 2019

description: Lo sviluppo di strategie di rigenerazione e riuso per il patrimonio culturale ecclesiastico non può sottrarsi a una preliminare e accurata valutazione delle condizioni di sicurezza e vulnerabilità degli edifici, soprattutto in un territorio come quello italiano, soggetto a una pluralità di rischi (sismico, idrogeologico, franoso, ecc.). In aggiunta alle analisi di tipo tecnico, lo studio delle vulnerabilità e delle diverse pericolosità per gli edifici di culto non può che radicarsi nella conoscenza storica e nell’interpretazione storica del territorio e dei manufatti. Il contributo presenta i primi esiti del programma di ricerca volto allo sviluppo di metodi per l’analisi delle diverse vulnerabilità a scala vasta per gli edifici di culto. L’applicazione di tali metodi, e i loro sviluppi futuri, consentono di elaborare strumenti a supporto delle decisioni per la gestione e la pianificazione delle attività di rigenerazione e riuso, nell’obiettivo di un’efficace e costante conservazione e valorizzazione del patrimonio culturale. Parole chiave: patrimonio culturale ecclesiastico, rischio, analisi storica, vulnerabilità, riuso
description: BDC. Bollettino Del Centro Calza Bini, Vol 19 No 1 (2019): The Circular Economy Model: from the Building Functional Reuse to the Urban System Regeneration
title: Spannungsfelder in Veränderungsprozessen und deren Bedeutung für Führungskräfte in Steuerberatungskanzleien
Creators: name: Bruckner, Kerstin Maria
Publisher: name: FH CAMPUS 02 (CAMPUS 02 Fachhochschule der Wirtschaft)
Year: 2024
Subjects: subject: 658 Allgemeines Management

description: Die aktuellen Entwicklungen der Arbeitswelt treiben Veränderungsprozesse in Unternehmen voran. Insbesondere die technologischen Entwicklungen, Veränderungen in der Gesellschaft und der demografische Wandel sind Treiber für Veränderungen in Organisationen und in der MitarbeiterInnenführung. Die VUCA-Umwelt erfordert Schnelligkeit und Flexibilität in Arbeitsabläufen und Organisationsstrukturen. Wissenschaftlicher Nutzen dieser Masterthesis besteht darin, die Spannungsfelder in diesen Veränderungsprozessen in Steuerberatungskanzleien zu untersuchen. Für die Erstellung des Theorieteils erfolgte eine umfassende Literaturrecherche. Hier wurden die Gründe für Veränderungen im Führungsstil bzw. neue Führungsstilkonzepte und wesentliche Erfolgsfaktoren im Veränderungsmanagement aufgezeigt. Durch die veränderten Rahmenbedingungen ergeben sich Herausforderungen und Spannungsfelder für Führungskräfte. In der empirischen Forschung wurden zwölf FachexpertInnen zum Thema befragt. Sechs Interviews wurden mit Führungskräften aus Steuerberatungskanzleien durchgeführt. Um die Meinungen aus der Außenansicht zu erhalten, fanden Interviews mit sechs BeraterInnen statt. Es wurde hinterfragt, welche Herausforderungen für die Führungskräfte in diesen Veränderungsprozessen entstehen und welche Änderungen in Steuerberatungskanzleien vorzunehmen sind, um zukunftsfähig zu bleiben. Da die Implementierung von Veränderungen in traditionellen, starren Prozessen und Strukturen oftmals zu Problemen und Spannungen führt, wurde hier nach Strategien und Lösungswegen zur Bewältigung dieser Spannungsfelder gesucht. Die Forschungsergebnisse zeigen, dass in Steuerberatungskanzleien, vor allem durch die Corona Pandemie, Digitalisierungsprozesse und organisationale Änderungen beschleunigt wurden. Spannungen entstehen größtenteils durch MitarbeiterInnendiversität, gegenseitiges Unverständnis in der Belegschaft, rasche Digitalisierungsprozesse und die geforderte Agilität vom Umfeld. Es geht deutlich hervor, dass Methoden des Veränderungsmanagements, die in der Literatur genannt wurden, positiv zu einem erfolgreichen Wandel beitragen. Ein weiteres Resultat ist, dass eine gute Kommunikation und die Ermächtigung der MitarbeiterInnen eine positive Unternehmenskultur fördern. Eine klar definierte strategische Zielsetzung trägt als weiterer bedeutender Erfolgsfaktor zu einem erfolgreichen Wandel bei.
ADAPTIVE REUSE DI BENI ARCHITETTONICI RELIGIOSI. RESTAURO E INCLUSIONE SOCIALE IN ALCUNI CASI STUDIO TORINESI
Creators: name: Bartolozzi, Carla
name: Dabbene, Daniele
name: Novelli, Francesco
Publisher: name: BDC. Bollettino Del Centro Calza Bini
Year: 2019

description: Il riuso del patrimonio architettonico religioso dismesso o sottoutilizzato rappresenta in Italia e in Europa un tema di grande attenzione. Il contributo proposto analizza le relazioni che intercorrono fra le esigenze di tutela e conservazione ed il possibile riuso con finalità sociale di questo patrimonio storico. Quali denominatori comuni emergono in iniziative che vedono la partecipazione di enti del terzo settore con il ruolo di proponenti o gestori del bene? Ci si interroga sul grado di compatibilità alle nuove funzioni, con attenzione alle diverse tipologie di progettazione che si riscontrano in situazioni di riuso adattivo finalizzato tanto alla valorizzazione quanto all’inclusione. I casi studio individuati a Torino (Italia) sono tutti edifici di riconosciuto valore storico, proprietà di enti religiosi in cui la gestione della struttura è demandata ad enti del terzo settore. Parole chiave: progetto di restauro, riuso, valorizzazione, inclusione sociale
description: BDC. Bollettino Del Centro Calza Bini, Vol 19 No 1 (2019): The Circular Economy Model: from the Building Functional Reuse to the Urban System Regeneration
Sayad, Abdelmalek. The Suffering of the Migrant. Pierre Bourdieu’nün önsözüyle.
Creators: name: İbişoğlu, Müşerref İrem
name: Quintern, Detlev
Publisher: name: Türk-Alman Bakış Açıları
Year: 2023

description: Türk-Alman Bakış Açıları, Bd. 1 (2023): Türkisch-Deutsche Perspektiven
(502379) Gabrielle Emma Crowdy
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: Development of chemical probe ML315
Creators: name: Shen, M.
name: Wang, J.L.
name: Schoenen, F.J.
name: Thomas, C.J.
name: Tanega, C.
name: Auld, D.S.
name: Aubé, J.
name: Coombs, T.C.
name: Gerritz, S.W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Substituted pyrimidine inhibitors of the Clk and Dyrk kinases have been developed, exploring structure-activity relationships around four different chemotypes. The most potent compounds have low-nanomolar inhibitory activity against Clk1, Clk2, Clk4, Dyrk1A and Dyrk1B. Kinome scans with 442 kinases using agents representing three of the chemotypes show these inhibitors to be highly selective for the Clk and Dyrk families. Further off-target pharmacological evaluation with ML315, the most selective agent, supports this conclusion.
Additional file 1 of Struct2Graph: a graph attention network for structure based predictions of protein–protein interactions
Creators: name: Baranwal, Mayank
name: Magner, Abram
name: Saldinger, Jacob
name: Turali-Emre, Emine S.
name: Elvati, Paolo
name: Kozarekar, Shivani
name: VanEpps, J. Scott
name: Kotov, Nicholas A.
name: Violi, Angela
name: Hero, Alfred O.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Additional file 1: List of important residues as predicted by Struct2Graph.
(502426) James Howard
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
STRATEGIE DI VALORIZZAZIONE SOCIALE DI CONVENTI E MONASTERI ITALIANI: LA COSTRUZIONE DI PROCESSI DI RIUSO ADATTIVO
Creators: name: Giani, Francesca
name: Giofrè, Francesca
Publisher: name: BDC. Bollettino Del Centro Calza Bini
Year: 2019

description: Negli ultimi decenni in Italia le case religiose stanno subendo un importante decremento numerico causato dalla decrescita dei religiosi. L’articolo definisce l’insieme delle case religiose e ne analizza i dati nell’arco temporale 2013-2017. Discute poi due casi di studio di riuso adattivo finalizzato alla valorizzazione sociale di un monastero e di un convento, con particolare attenzione ai processi attivati. Le motivazioni, i tempi, le modalità di attivazione del processo ed i suoi esiti, letti anche in riferimento al diverso valore culturale degli immobili e alla natura perdurante dei beni ecclesiastici, evidenziano alcune criticità e fanno emergere strategie, validate da altre esperienze analoghe. In conclusione l’articolo propone un’ipotesi di processo atto a guidare le scelte finalizzate al riuso, capaci di rinnovare la presenza identitaria e sociale delle case religiose sul territorio. Parole chiave: case religiose, processi, riuso adattivo
description: BDC. Bollettino Del Centro Calza Bini, Vol 19 No 1 (2019): The Circular Economy Model: from the Building Functional Reuse to the Urban System Regeneration
STORIE DI ARCHITETTURA ECCLESIALE E PROCESSI DI PATRIMONIALIZZAZIONE: VALORI, RESILIENZA, ADATTIVITÀ, RIUSO
Creators: name: Longhi, Andrea
Publisher: name: BDC. Bollettino Del Centro Calza Bini
Year: 2019

description: Lo studio dell’architettura delle chiese inteso come storia di processi sociali consente di definire, riconoscere e discutere un’ampia gamma di valori che ha storicamente guidato i processi decisionali di trasformazione degli edifici di culto. L’identificazione di tali valori ecclesiali plurali può consentire una mappatura puntuale dei significati dei luoghi, e contribuisce a una definizione periodizzata di quel “valore intrinseco” del patrimonio su cui può fondarsi un suo utilizzo consapevole e responsabile. L’analisi processuale della storia dei luoghi ecclesiali racconta inoltre il delicato rapporto tra adattività e resilienza, ossia la capacità del patrimonio di rispondere in modo innovativo a pressioni e traumi, conservando la propria riconoscibilità nel quadro di equilibri di volta in volta rinnovati. Tali dinamiche possono diventare chiave interpretativa utile nella discussione dei processi decisionali volti alla dismissione e al riuso del patrimonio ecclesiale sottoutilizzato o abbandonato. Parole chiave: patrimonio religioso, resilienza, riuso, storia dell’architettura
description: BDC. Bollettino Del Centro Calza Bini, Vol 19 No 1 (2019): The Circular Economy Model: from the Building Functional Reuse to the Urban System Regeneration
Additional file 2 of A novel high performance in-silico screened metagenome-derived alkali-thermostable endo-β-1,4-glucanase for lignocellulosic biomass hydrolysis in the harsh conditions
Creators: name: Ariaeenejad, Shohreh
name: Atefeh Sheykh Abdollahzadeh Mamaghani
name: Maleki, Morteza
name: Kavousi, Kaveh
name: Shahraki, Mehdi Foroozandeh
name: Ghasem Hosseini Salekdeh
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 2.
“Kültür” İle Çalışmak – Kültüre Duyarlı Klinik Psikolojiden Örnekler ve Gelecek Perspektifleri
Creators: name: Yılmaz, Süheyla
name: Balcı, Sümeyye
Publisher: name: Türk-Alman Bakış Açıları
Year: 2023

description: Son yıllarda, psikolojide kültürel konuların ele alınması önemli ölçüde artmıştır. Kültürle çalışan alanlar arasında örneğin kültürlerarası gelişim psi-kolojisi ve klinik psikoloji, kültürel psikoloji ve yerli psikolojisi yer almakta-dır. Bununla birlikte, müdahalelerin, terapötik yaklaşımların ve uygulama-ların temelleri ağırlıklı olarak Avrupa ve Kuzey Amerika kültüründen gelen popülasyonların sağladığı araştırma bulgularına ve deneyimlerine dayan-maktadır. Bu kısa makalede, kültüre duyarlı klinik psikolojiden örnekler sun-makta ve kültürel açıdan bilgilendirilmiş psikolojik araştırmaların geleceğine kısa bir bakış sağlamaktayız.
description: Türk-Alman Bakış Açıları, Bd. 1 (2023): Türkisch-Deutsche Perspektiven
Additional file 2 of Struct2Graph: a graph attention network for structure based predictions of protein–protein interactions
Creators: name: Baranwal, Mayank
name: Magner, Abram
name: Saldinger, Jacob
name: Turali-Emre, Emine S.
name: Elvati, Paolo
name: Kozarekar, Shivani
name: VanEpps, J. Scott
name: Kotov, Nicholas A.
name: Violi, Angela
name: Hero, Alfred O.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Additional file 2: List of missense variants annotated in UniProtKB/Swiss-Prot human entries.
Additional file 7 of Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease
Creators: name: Barthelson, Karissa
name: Pederson, Stephen Martin
name: Newman, Morgan
name: Lardelli, Michael
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 7: Results from enrichment analysis are mostly not driven by expression of the same genes. The upset plots show the overlap of the “leading edge” genes from the fgsea algorithm in each of the significant gene sets in a EOfAD-like/+, b null/+, and c transheterozygous mutant brains. Intersections are shown when the leading edge of the gene sets share three or more genes. Overall, the leading edge genes of the significantly altered gene sets are relatively independent of one another. However, genes in the oxidative phosphorylation gene sets and the gene sets for neurodegenerative diseases (Alzheimer’s, Parkinson’s and Huntington’s diseases) all contain genes encoding components of the electron transport chain and are capturing a portion of the same gene expression signal, which is shown in d and e. Missing positions in d and e indicate that the gene was not in the leading edge for that gene set.
Additional file 9 of Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease
Creators: name: Barthelson, Karissa
name: Pederson, Stephen Martin
name: Newman, Morgan
name: Lardelli, Michael
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 9: Pathview visualisation of the KEGG oxidative phosphorylation gene set. The logFC of the genes in the KEGG oxidative phosphorylation gene set are shown in each sorl1 genotype comparison with wild type. Intensity of the colours indicates the magnitude of the logFC, and white indicates that a gene was not detected as expressed in the RNA-seq experiment. Plot was adapted from pathview [83].
(502428) James Edwards
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.