cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The role of palmitoylation in endoplasmic reticulum transport and quality control of the yeast polytopic protein Chs3
Creators: name: Lam, Karen Kar Yan
Publisher: name: University of British Columbia
Year: 2009

description: All secretory proteins must pass the strict quality control (QC) imposed by the endoplasmic reticulum (ER), where they are first synthesized. Various chaperones, degradation machinery, and vesicular transport factors act together to ensure only properly folded proteins can leave this compartment for subsequent sorting. Failure in QC contributes to misfolding, intracellular retention, and frequently degradation, all of which are known to cause disease. QC is particularly crucial for polytopic proteins, which often represent plasma membrane transporters and channels important for cell function. Recent work suggests ER surveillance systems for polytopic proteins are specialized towards substrates and specific misfolding defects. The underlying mechanisms, especially the roles of post-translational modifications, are poorly understood, thus necessitating examination of various model proteins. Here, the yeast chitin synthase Chs3 was used as a paradigm for polytopic protein trafficking. By high-throughput analysis of the yeast deletion collection, a novel Chs3 ER transport factor was identified. This protein, Pfa4, contains a conserved DHHC-domain, signifying its putative function as a protein acyltransferase. These enzymes of protein palmitoylation were only recently discovered, and few substrates are known. The work described here showed that Chs3 was palmitoylated by Pfa4, and this modification was required for ER export. Both palmitoylation and association with the chaperone Chs7 were necessary for preventing Chs3 aggregation at the ER, indicating that palmitoylation is required for Chs3 to attain an export-competent conformation. Retention of misfolded Chs3 appeared independent of known ER-associated degradation machinery. Instead, a high-throughput search identified the Ubp3 deubiquitination enzyme as a retention factor; deletion of UBP3 restored ER export of unpalmitoylated Chs3 through palmitoylation-independent means. Ubp3-mediated deubiquitination may be regulating the levels of proteins involved in both Chs3 folding and Golgi-to-ER retrieval of misfolded Chs3. The role of palmitoylation in folding at the ER is not well known, and many substrate-specific retention pathways for polytopic proteins have not been identified. These findings suggest palmitoylation can contribute to ERQC of polytopic proteins, and point to potentially novel QC factors that are regulated by deubiquitination. A better understanding of these fundamental molecular mechanisms could contribute to discovery of therapeutic targets for ER misfolding diseases.
DESIGN NOVELTY EVALUATION THROUGH ORDINAL EMBEDDING: COMPARISON OF NOVELTY AND TRIPLET ERRORS
Creators: name: Keeler, Matthew Garrett
Publisher: name: Digital Repository at the University of Maryland
Year: 2024
Subjects: subject: Engineering
subject: Concept Generation
subject: NMDS
subject: Novelty Estimation
subject: Ordinal Embedding
subject: Preliminary Design
subject: Triplet

description: A practical and well-studied method for computing the novelty of a design is to construct an embedding via a collection of pairwise comparisons between items (called triplets), and use distances within that embedding to compute which designs are farthest from the center. These triplet comparisons are posed in the form of "Is Design A closer to Design B or Design C?'', and inform the placement of designs in the similarity-space embedding. This method of creating an embedding from non-metric relationship comparisons is known as ordinal embedding. Unfortunately, ordinal embedding methods can require a large number of triplets before their primary error measure--the proportion of violated triplet comparisons--converges. But if our goal is accurate novelty estimation, is it really necessary to fully minimize all triplet violations? Can we extract useful information regarding the novelty of all or some items using fewer triplets than existing convergence rates on the saturation of triplet violations might imply? This thesis addresses this question by studying the relationship between triplet violation error and novelty score error when using ordinal embeddings. We find that estimating the novelty of a set of items via ordinal embedding can require significantly fewer human-provided triplets than is needed to converge the triplet error, and that this effect is modulated by the type of triplet sampling method (random versus uncertainty-informed active sampling). Having learned this, we propose the use of a custom metric we call the 'Expected Model Change' (EMC) which we use to observe when novelty information in the embedding has stopped updating under newly labeled triplets, so that conservative bounding functions need not be used. Moreover, to avoid the dangers of low accuracy in selecting the dimension of the ordinal embedding, we propose use of the Expected Model Change for tuning the embedding dimension to an appropriate value. In this framework, we explore the convergence properties of ordinal embeddings reconstructed from triplets taken from a variety of synthetic and real-world design spaces.
Amtliches Verzeichnis der Lehrer, Beamten und Studierenden an der Königlich-Bayerischen Ludwig-Maximilians-Universität zu München 1864; 1864
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 1864

description: Textfreie Seiten wurden entfernt.
Additional file 1: of Medicaid prescription limits: policy trends and comparative impact on utilization
Creators: name: Lieberman, Daniel
name: Polinski, Jennifer
name: Niteesh Choudhry
name: Avorn, Jerry
name: Fischer, Michael
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Computational Biology

description: Online methods. Online results. Online Table S1. Sources of policy information organized by state. Online Table S2. Missing state policy information. Online Table S3. Proportion of prescription usage for medications before and after cap implementation. Online Table S4. Model parameter estimates. Online Figure S1. Proportion of prescriptions and spending accounted for by brand drugs before and after implementation of brand cap policies. (DOCX 165Â kb)
Redundancy of temporal envelope information across frequency bands in normal hearing individuals
Creators: name: Lister, Adrian Mark
Publisher: name: University of British Columbia
Year: 2009

description: Much research has focused on the role of different spectral aspects of the speech signal in speech perception. To date there had been little quantification of the temporal envelope of the speech signal for speech perception. The goal of this study was to examine the role of temporal envelope information in speech recognition by quantifying the shared temporal envelope information extracted from neighbouring high frequency 1/3-octave bands. The Envelope Difference Index (EDI) was used in the current study to calculate similarity of temporal envelope information between adjacent bands. There was significant shared information, but also novel information as well. In general, for listeners identifying nonsense words from limited temporal information, their speech recognition performance increased as the gap between two bands increased. Furthermore, the amount of shared information between 1/3 octave bands also decreased as a function of gap size. The acoustic measure of redundancy between pairs of bands did not predict intelligibility. Based on these results, models of speech intelligibility must account for this redundancy rather than assuming that bands can be analyzed and weighted individually.
Additional file 3: of Label-free proteomic methodology for the analysis of human kidney stone matrix composition
Creators: name: Witzmann, Frank
name: Evan, Andrew
name: Coe, Fredric
name: Worcester, Elaine
name: Lingeman, James
name: Williams, James
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: 60506 Virology

description: Human Kidney Stone Matrix Proteome Database – 1,039 proteins found in human kidney stone matrices from this study and 12 other proteomic papers. Includes details regarding Isoelectric Point, negatively charged residues (Asp + Glu), positively charged residues (Arg + Lys), Neg/Pos Ratio, Aliphatic index, GRAVY score, Molecular Class, Biological Process, Cellular component, and Function. (PDF 316 kb)
Additional file 2: of Label-free proteomic methodology for the analysis of human kidney stone matrix composition
Creators: name: Witzmann, Frank
name: Evan, Andrew
name: Coe, Fredric
name: Worcester, Elaine
name: Lingeman, James
name: Williams, James
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Peptide sequence/Protein Identification, mass spectral data for 5,957 peptides. (PDF 3099 kb)
Additional file 1: Table S1. of Effects of light environment during growth on the expression of cone opsin genes and behavioral spectral sensitivities in guppies (Poecilia reticulata)
Creators: name: Sakai, Yusuke
name: Ohtsuki, Hajime
name: Kasagi, Satoshi
name: Kawamura, Shoji
name: Masakado Kawata
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Proportion of variance and eigenvalues for the first three principal components from opsin gene expression (proportional expression) data. Table S2. The mean (± SEM) lens density values at which optomotor responses were less than 0.5 (gain threshold). Table S3. Primers for real-time qPCR; Mean PCR efficiencies (± SE) and r-square values for each gene assay were calculated using serial dilutions of plasmid standards. Table S4. PCR and sequencing primers for LWS-1. Figure S1. Characteristics of green and orange experimental light environments; (A) Relative irradiance spectra of green and orange light environments during growth; spectra were normalized to peak intensity values; (B) Computed quantum catches by visual opsins of green and orange light spectra. Figure S2. The attenuation of light intensity (photon flux density) of the four stimulus wavelengths by neutral density filters. Downwelling light intensities of stimulus light were measured in the middle of the acrylic cylinder tank using a spectrometer (USB2000). Figure S3. Computed quantum catches by visual opsins of 532, 546, 570 and 600-nm light. Figure S4. Cross-correlation matrix of gene expression of cone opsins relative to house keeping genes. Correlation coefficients among cone opsin gene expression values were displayed by heat map. In the color spectrum bar, red and blue indicate positive and negative correlation, whereas gray indicates no correlation. (DOCX 265 kb)
Additional file 1: Table S1. of Susceptibility to cigarette smoking among secondary and high school students from a socially disadvantaged rural area in Poland
Creators: name: PolaĹSka, Kinga
name: Wojtysiak, Piotr
name: K-Romaniszyn, Leokadia BÄ
name: Kaleta, Dorota
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 60506 Virology

description: Baseline characteristics of the sample. Table S2. Prevalence of susceptibility to smoking among the secondary and high school students from Piotrkowski district. (DOCX 23Â kb)
Additional file 2: of Towards a simple typology of international health partnerships
Creators: name: Edwards, Suzanne
name: Ritman, Dan
name: Burn, Emily
name: Dekkers, Natascha
name: Baraitser, Paula
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Absolute and relative scope of influence. Table with data used for chi-squared test for an association between the variables absolute scope of influence and relative scope of influence. (DOCX 22Â kb)
Additional file 5: of Label-free proteomic methodology for the analysis of human kidney stone matrix composition
Creators: name: Witzmann, Frank
name: Evan, Andrew
name: Coe, Fredric
name: Worcester, Elaine
name: Lingeman, James
name: Williams, James
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Marine Biology
subject: Computational Biology

description: Functional Annotation Clustering of kidney stone matrix proteins obtained from the DAVID database. (PDF 100 kb)
Outcome prediction and genome-transcriptome correlation analysis in classical Hodgkin's lymphoma
Creators: name: Lee, Tang
Publisher: name: University of British Columbia
Year: 2009

description: Treatment outcome prediction in classical Hodgkin’s Lymphoma is currently standardized with the International Prognostic Score (IPS), a scoring system based on 7 clinical parameters: age, stage, sex, serum albumin, absolute lymphocyte count or percentage, hemoglobin, and white blood cell count. Known limitations of the system are that it is tailored for advanced-stage patients, and it is unable to identify patients with very poor prognosis. In our dataset of 100 cases, the IPS predicted only 28% of the treatment Failures correctly, and 78% treatment successes correctly. We examined the outcome predictive power of whole-tumour gene expression profiling (GEP) in comparison to the clinical parameters, to see whether additional predictive power can be gained by combining the two data sources. Random Forests and Sparse Multinomial Logistic Regression were used for classification and feature importance ranking. Receiver-Operator Characteristic (ROC) curves and Area Under the Curve (AUC) values did not suggest a significant improvement with GEP, but potentially important GEP predictors were revealed (CSDA, DPEP2, PDE4D, HBP1, etc) and only one of the seven clinical parameters (Ann Arbor Stage) was found to have predictive value. The use of whole-tumour GEP warranted that very limited amount of data reflected the biology of the malignant Hodgkin Reed Sternberg (HRS) cells, since these cells take up only 1-2% of the whole tumour. Treatment response/outcome likely involves a significant contribution by the HRS cells, therefore examining only an enriched pool of micro-dissected HRS cells would be very beneficial. Twelve cases of micro-dissected HRS cells were available, and this limited sample size prevented the development of a reliable classification model. Instead, we gained insights into the biology of HRS cells by examining the relationship between DNA copy number (CN), as profiled by array CGH, and GEP. The second part of the thesis involved a single-sample strategy for the examination of the twelve cases and a joint analysis to compare between cases of different CN status. Sparse patterns of correlations with CN gains were found on chromosomes 2p, 6p, 9p, and 12p, including locus JAK2 which has known correlation with gain of 9p.
Additional file 1: Table S1. of Evolutionary patterns of Toll-like receptor signaling pathway genes in the Suidae
Creators: name: Kwame Darfour-Oduro
name: Hendrik-Jan Megens
name: Roca, Alfred
name: Groenen, Martien
name: Schook, Lawrence
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Sample information. (DOCX 12Â kb)
Additional file 4: Table S3. of Evolutionary patterns of Toll-like receptor signaling pathway genes in the Suidae
Creators: name: Kwame Darfour-Oduro
name: Hendrik-Jan Megens
name: Roca, Alfred
name: Groenen, Martien
name: Schook, Lawrence
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Summary statistics for genes. (DOCX 14Â kb)
Consumption of sugary drinks among children and their parents or caregivers
Creators: name: Kruse, Kerri
Publisher: name: Health New Zealand
Year: 2024
Subjects: classificationCode: 420603
subject: Health promotion

description: The increasing consumption of sugary drinks has been a major factor contributing to the global obesity epidemic. These 'liquid lollies' also increase the risk of other health conditions such as type 2 diabetes, heart disease, gout, dental decay, and dental erosion. Parents and caregivers are encouraged to give their children water and low-fat unflavoured milk and to role model healthy behaviours by limiting their own consumption of these beverages. HPA’s nutrition and physical activity programme promotes these beverage recommendations. Data on what families eat and drink from HPA’s 2012 Health and Lifestyles Survey is in this fact sheet.
Additional file 1: of Towards a simple typology of international health partnerships
Creators: name: Edwards, Suzanne
name: Ritman, Dan
name: Burn, Emily
name: Dekkers, Natascha
name: Baraitser, Paula
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Impact and approach. Table with data used for chi-squared test for an association between the variables absolute scope of influence and strategy for capacity building. (DOCX 22Â kb)
Additional file 1 of Gene expression prediction using low-rank matrix completion
Creators: name: Arnav Kapur
name: Kshitij Marwah
name: Alterovitz, Gil
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: In this supplement, we provide additional discussion and further analysis on additional studies. (PDF 851 kb)
Additional file 4: of Label-free proteomic methodology for the analysis of human kidney stone matrix composition
Creators: name: Witzmann, Frank
name: Evan, Andrew
name: Coe, Fredric
name: Worcester, Elaine
name: Lingeman, James
name: Williams, James
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Ingenuity Pathway Analysis Results - Canonical Pathways associated with Kidney stone matrix proteins. (PDF 60 kb)
Additional file 3: of Development and use of a research productivity assessment tool for clinicians in low-resource settings in the Pacific Islands: a Delphi study
Creators: name: Ekeroma, Alec
name: Shulruf, Boaz
name: McCowan, Lesley
name: Hill, Andrew
name: Kenealy, Tim
Publisher: name: Figshare
Year: 2016
Subjects: Developmental Biology
Science Policy

description: Questionnaire for BRRACAP Study participants: Review of research/audit performance activity. (DOC 30 kb)
YEVROPA KENGASHI DOIRASIDA YETIM BOLALAR VA OTA-ONA QARAMOG'IDAN MAHRUM BO'LGAN BOLALAR HUQUQLARINI HIMOYA QILISHNING HUQUQIY ASOSLARI
Creators: name: Turdibekov, Ahror
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada Yevropa Kengashi doirasida yetim bolalar va ota-ona qaramog‘idan mahrum bo‘lgan bolalarni himoya qilishning huquqiy asoslari tahlil qilinadi. Ushbu tadqiqot jarayonida, Yevropa Kengashida yetim bolalar va ota-ona qaramog‘idan mahrum bo‘lgan bolalar huquqlarini ta’minlashga doir konvensiya, direktiva, Yevropa Sudi qarorlari va boshqa huquqiy asoslarini o‘rganiladi. O‘rganish natijasida, Yevropa kengashi doirasida yetim bolalar va ota-ona qaramog‘idan mahrum bo‘lgan bolalar huquqlarini himoya qilishga doir taklif va xulosalar beriladi.
Additional file 6: Table S5. of Evolutionary patterns of Toll-like receptor signaling pathway genes in the Suidae
Creators: name: Kwame Darfour-Oduro
name: Hendrik-Jan Megens
name: Roca, Alfred
name: Groenen, Martien
name: Schook, Lawrence
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Bivariate correlations among variables. (DOCX 13Â kb)
Additional file 2: of Development and use of a research productivity assessment tool for clinicians in low-resource settings in the Pacific Islands: a Delphi study
Creators: name: Ekeroma, Alec
name: Shulruf, Boaz
name: McCowan, Lesley
name: Hill, Andrew
name: Kenealy, Tim
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Hematology

description: Delphi Questionnaire 2: Determining research performance activity or indicators for pacific clinical researchers. (DOC 156 kb)
Cliona celata Grant 1826
Creators: name: Schönberg, Christine Hanna Lydia
name: Grass, Stefanie
name: Heiermann, Anke Tarja
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Porifera
Demospongiae
Hadromerida
Clionaidae
Cliona
Cliona celata

description: Cliona celata Grant, 1826
Diagnosis
Excavating Hadromerida in, and growth form (cryptic­papillate, crypticencrusting and free­living), with tylostyles, styles and\or oxeas and spirasters, raphides, amphiasters and\or microrhabds. Skeleton of the choanosome confused, ectosome in palisade. Original family name Clionidae preoccupied (Gastropoda: Rafinesque 1815), amended by Bouchet and Rützler (2003). Synonymies given by Rützler (2002b).
description: Published as part of Schönberg, Christine Hanna Lydia, Grass, Stefanie & Heiermann, Anke Tarja, 2006, Cliona minuscula, sp. nov. (Hadromerida: Clionaidae) and other bioeroding sponges that only contain tylostyles, pp. 1-24 in Zootaxa 1312 on page 3, DOI: 10.5281/zenodo.173882
Additional file 2 of Gene expression prediction using low-rank matrix completion
Creators: name: Arnav Kapur
name: Kshitij Marwah
name: Alterovitz, Gil
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: In this file, we provide description and sources of studies used in this study. (PDF 516 kb)
Additional file 1: of Australian Aboriginal and Torres Strait Islander-focused primary healthcare social and emotional wellbeing research: a systematic review protocol
Creators: name: Farnbach, Sara
name: Eades, Anne-Marie
name: Maree Hackett
Publisher: name: Figshare
Year: 2015
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy

description: Additional file 1: Definitions and potential actions for the Values. (32.6 kb)
Cliona celata Grant 1826
Creators: name: Schönberg, Christine Hanna Lydia
name: Grass, Stefanie
name: Heiermann, Anke Tarja
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Porifera
Demospongiae
Hadromerida
Clionaidae
Cliona
Cliona celata

description: Cliona celata Grant, 1826
Diagnosis
Clionaidae in, and growth form, with tylostyles as megascleres; microscleres, if present, spirasters or raphides, which may vary in form. Synonymies given by Rützler (2002b).
description: Published as part of Schönberg, Christine Hanna Lydia, Grass, Stefanie & Heiermann, Anke Tarja, 2006, Cliona minuscula, sp. nov. (Hadromerida: Clionaidae) and other bioeroding sponges that only contain tylostyles, pp. 1-24 in Zootaxa 1312 on page 3, DOI: 10.5281/zenodo.173882
Additional file 2: Table S2. of Evolutionary patterns of Toll-like receptor signaling pathway genes in the Suidae
Creators: name: Kwame Darfour-Oduro
name: Hendrik-Jan Megens
name: Roca, Alfred
name: Groenen, Martien
name: Schook, Lawrence
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Genes of the Sus scrofa TLR signaling pathway used in querying genomes of other species of the Suidae. (DOCX 13Â kb)
Genomics of adaptation to local climate in Sitka spruce (Picea sitchensis)
Creators: name: Holliday, Jason A.
Publisher: name: University of British Columbia
Year: 2009

description: Genecological studies in widely distributed tree species have revealed steep genetic clines along environmental gradients for traits related to adaptation to local climate. In the face of a changing climate, the ecological and economic importance of conifers necessitates an appraisal of how molecular genetic variation shapes quantitative trait variation. I have combined transcript profiling with association mapping to better understand the genomic architecture of adaptation to local climate in conifers, using Sitka spruce (Picea sitchensis) as a model. A microarray study during the fall hardening period revealed wholesale remodeling of the transcriptome within a population originating in the centre of the species range, and substantial variation in the autumn transcriptome was observed when populations from the northern and southern limits of the range were compared. Based on these data, a suite of candidate genes was selected and screened for single nucleotide polymorphisms (SNPs) in a panel of 24 individuals. A diverse array of biological processes were represented among the candidate genes, including stress response, carbohydrate, lipid and phenylpropanoid metabolism, light signal transduction, and transcriptional and posttranscriptional regulation. Nucleotide diversity in Sitka spruce was approximately average for a conifer (π = 3.49 x 10⁻³), and linkage disequilibrium decayed rapidly. Tests of selective neutrality suggest widespread purifying selection within these candidate genes, though evidence for positive selection was detected within a few. In addition, I observed evidence for diversifying selection in 8% of the studied genes, which exhibited high population differentiation relative to the genome-wide average FST of 0.12. To identify genetic determinants of phenotypic variation in locally adaptive traits, an Illumina GoldenGate assay was used to genotype 768 SNPs in a mapping population comprised of 410 individuals from 12 geographical populations collected from across the species range. After correcting for population structure and relative kinship, associations were detected in 28 of the candidate genes, which cumulatively explained 28% and 34% of the phenotypic variance in cold hardiness and budset, respectively. Most notable among these associations were five genes putatively involved in light signal transduction, the key pathway regulating autumn growth cessation in perennials. This study represents a significant step toward the goal of characterizing the genomic underpinnings of adaptation to local climate in conifers, and provides a substantial resource for breeding and conservation genetics in a changing climate.
With Eyes No Longer Blind: Vision and Visibility in Engineering
Creators: name: Barabino, Gilda A.
Publisher: name: Carnegie Mellon University
Year: 2025
Subjects: classificationCode: 40
subject: Engineering
classificationCode: 390303
subject: Higher education

description: This lecture was first presented on February 19, 2025 at Carnegie Mellon University, Pittsburgh, PA, as part of the University Lecture Series, by Dr. Gilda A. Barabino, recipient of the 2024 Dickson Prize in Science. Carnegie Mellon's Dickson Prize in Science is awarded annually to the person who has been judged by the university to have made the most progress in the scientific field in the United States for the year in question. At Carnegie Mellon, the field of science is interpreted to include the natural sciences, engineering, computer science or mathematics.Published by Tartan Editions, an imprint of Carnegie Mellon University Press.
El diseño instruccional y la experiencia del usuario en la construcción de recursos tecnopedagógicos
Creators: name: Molina Duarte, Juan Carlos
name: Briceño-Rivero, Inesmar
name: Millán -Torres, Edgar S.
name: Estanga-Barrios, Marisela
Publisher: name: Zenodo
Year: 2024
Subjects: TIC, User Experience (UX), Atlas.ti, diseño instruccional

description: Las Tecnologías de la Información y la Comunicación (TIC) son un concepto en constante evolución a lo largo del tiempo. En muchos casos, Internet ha sido el motor detrás del continuo crecimiento de diversos recursos y objetos de aprendizaje desarrollados a través de herramientas y software informáticos, los cuales brindan apoyo en los procesos educativos. Este artículo busca proporcionar una reflexión que nos permita situarnos en un contexto temporal y espacial específico. Se pretende analizar si la experiencia de usuario, conocida como User Experience (UX), está relacionada con el diseño instruccional en el ámbito de la tecnopedagogía, y si realmente se adapta a las necesidades de los estudiantes. A partir de la categorización, la codificación y la triangulación por medio del Atlas.ti, se realizó una aproximación teórica de los significados y sentidos del diseño instruccional desde la mirada de los actores sociales. De esta manera, desde las consideraciones de la UX, es importante conocer la percepción y la actitud del diseñador instruccional con el fin de interpretar los procesos pedagógicos inmersos en los sistemas de educación en línea, plataformas, cursos o incluso recursos de aprendizaje específicos para que podamos pensar de qué forma poder implementar procesos de gestión para crear, desarrollar y mejorar continuamente recursos que apoyen el proceso de enseñanza aprendizaje. La investigación ha confirmado que la UX desempeña un papel fundamental en la efectividad de los recursos tecnopedagógicos. Los diseñadores instruccionales reconocen la importancia de brindar una experiencia de usuario positiva y accesible.
JINOYAT PROTSESSIDA ISBOT QILISH VA UNDA MUTAXASSIS ISHTIROKIGA  OID AYRIM MULOHAZALAR
Creators: name: Abduvahobov, Sherzodbek
Publisher: name: Zenodo
Year: 2024

description: Jinoyat protsessida isbot qilish dalillarni to‘plash, tekshirish va baholashni o‘z ichiga qamrab oladi. Isbot qilish jarayonining mazmuni va mohiyati yuzasidan hozirgacha turlicha fikrlar va mulohazalar bildirib kelinmoqda [1, B.25].
Caragobius Smith and Seale
Creators: name: Edward O. Murdy
name: Koichi Shibukawa
Publisher: name: Zenodo
Year: 2003
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Gobiidae
Caragobius

description: [[Caragobius Smith and Seale]]
Caragobius typhlops was described as a new genus and species by Smith and Seale (1906) from five specimens collected from the Rio Grande near Cotabato, Mindanao, Philippines. Smith and Seale’s description of Caragobius was rather unremarkable except that they mentioned their specimens possessed “a small pore above each gill-opening which opens into a cavity separate from gill-cavity”; among gobioid fishes, this character is unique to Amblyotrypauchen, Ctenotrypauchen, Trypauchen, and Trypauchenichthys [members of the Trypauchen Group of Murdy (2002) as modified from Birdsong et al. (1988)]. Smith and Seale (1906) did state that Caragobius was related to Trypauchen but differed in “squamation, teeth, eyes, etc.”.
Herre (1927) examined Smith and Seale’s specimens of Caragobius typhlops and determined that the pore above the gill cavity [shallow pouch along the dorsal edge of the operculum] was not present in any of the specimens. Herre (1927) surmised that Smith and Seale (1906) may have confused a tear in the skin with a pore. Koumans (1940) concurred with Herre's assessment and allied Caragobius with his Taenioininae (Koumans, 1931), a group comprising eight genera, but none of the Trypauchen-Group genera named above. Furthermore, Koumans stated that Caragobius was probably synonymous with Brachyamblyopus, one of the members of his Taenioininae. Subsequently, Koumans (1953) provisionally synonymized Caragobius with Brachyamblyopus.
Birdsong et al. (1988) placed Caragobius in their Trypauchen Group, an assemblage that did not include Brachyamblyopus, but did include Amblyotrypauchen, Trypauchen, and Trypauchenichthys. This group was defined by its shared possession of a pterygiophore formula (PF) of 3-1221 that is unique among gobiid fishes. Murdy and Shibukawa (2002) reported that the holotype of Amblyopus brachysoma Bleeker (1853), the type for the genus Brachyamblyopus, has a PF=3-12210 and, thus, correctly belongs in the Taenioides Group of Birdsong et al. (1988).
Among Trypauchen-Group members, all but Caragobius and Karsten possess a shallow pouch along the dorsal edge of the operculum (“blind sac-shaped depression” of Hora, 1924); the function of this pouch is not known. Murdy (2002) proposed that Caragobius is the sister group to all other Trypauchen-Group members and Karsten is the sister group to all Trypauchen-Group members that possess an opercular pouch.
description: Published as part of Edward O. Murdy & Koichi Shibukawa, 2003, A revision of the Indo-Pacific fish genus Caragobius (Gobiidae: Amblyopinae)., pp. 1-12 in Zootaxa 301 on pages 1-2
High-resolution mutation detection in Caenorhabditis elegans mutants and natural isolates using array comparative genomic hybridization
Creators: name: Maydan, Jason Stephen
Publisher: name: University of British Columbia
Year: 2009

description: An essential requirement of genetic research is the ability to identify mutations. Forward genetic screens begin by selecting for a phenotype and proceed to search for the causative mutation. Reverse genetics experiments first identify the mutation and then seek to derive the mutant phenotype, if any. Both approaches depend on efficient means of detecting mutations. This thesis describes the development of methods to facilitate the detection of mutations in the model organism, Caenorhabditis elegans, using array Comparative Genomic Hybridization (aCGH). Exon-centric oligonucleotide microarrays targeting specific chromosomes and the whole genome were designed and used to detect both large multi-gene and small single-gene deletions. Both homozygous and heterozygous deletions were identified using this technique. I showed that even single nucleotide transitions and transversions are detectable when using microarrays with sufficient probe densities, which are achievable with target regions of two Mbp or less. I also used aCGH to detect extensive natural gene content variation between the N2 Bristol strain and twelve wild C. elegans isolates. Most of the DNA copy number alterations in these strains are deletions relative to Bristol. Over 5% of the genes present in the Bristol strain are absent in at least one of the natural isolates that were examined. This represents a significant increase in the number of genes with known null alleles. These deletions were then used to infer relationships among the natural isolates, which proved to be complex. The methods described in this thesis will greatly assist in the identification of mutations in C. elegans and are also applicable to other organisms with sequenced reference genomes.
EQUITABLE PROSPERITY: EXAMINING THE DYNAMICS OF PER CAPITA INCOME GROWTH AND INCLUSIVE DEVELOPMENT
Creators: name: Rajneesh Kler
name: Abu Bakar Bin Abdul Hamid
name: Noor Inayah Binti Ya'akub
name: Shobhit
name: Sanober Khan
name: Danish Ather
Publisher: name: Zenodo
Year: 2024
Subjects: Economic Growth, Living Conditions, Environmental Sustainability, Equality Developed Countries, Developing Countries, Quantile Regression, Heteroscedasticity, Autocorrelation.

description: Abstract

This paper aims to reveal the correlations between the annual average growth rates for populations and the living conditions in terms of equality as well as the environmental standpoint in different countries grouped by their level of development. These dimensions clearly depict the basic differences in the background of the developed and the developing countries. By performing ACMC and AUGPCAR tests, we are able to pinpoint non-linearities in the data and heteroscedasticity and auto correlation problems. To mitigate this, we introduce a couple of models and use the following approaches to answer them; First, we apply the quantile regression model since it is more robust than the ordinary Least Square regression. These assumptions evidence that, the rise in living standards and environmental quality have a positive impact on growth rates, however developed nations show convergence when growth spices are slow. Policy implications are focused on the investment in social wellbeing, environmental preservation, reducing inequity, and heteroscedasticity appropriate statistical analysis. These strategies are important for the cause of improving the global economy, with focus on the Keynesian principles of inclusiveness and sustainability.
论道教三魂七魄学说与生命起源哲学
Creators: name: Liu, Huan
Publisher: name: Jiangxi Province ChengZhu Environmental Engineering Company Ltd
Year: 2024

description: DOI: 10.58473/JBS0023     Retrieval from official database: www.crossref.org

Liu Huan (2023). 论道教三魂七魄学说与生命起源哲学. Journal of Biological Sciences (ISSN 2958-4035).2023(11). https://doi.org/10.58473/JBS00232024. Copyrights Certificate Registered by Brock Chain Technology: Brock Chain ID (82591123956a0d347afaf1d9eb736c304a0b2cea9ba576a8475d24646532f9ab) ; Registered Time: 2024-09-06 11:30;The formally published serials is the printing , and the serials NO. is the month/year when the materials is accessible on this website, authorized by publisher;正式发表的期刊是印刷版《生物科学杂志 (ISSN 2958-4035)》,期刊期号为文章内容在本网站上网年/月,出版人许可自行正式发表。Originality Statement: The originality of this article has been tested and checked by Turnitin (International).All Copyrights Reserved.

 

Scilit Database Retrieval URL : Link

 

Web of Science Retrieval URL: https://publons.com/wos-op/publon/66151049/

 

Researchgate: Link

 

PlumX Metrics: Link

 

BASE: Link
论道教三魂七魄学说与生命起源哲学
Creators: name: Liu, Huan
Publisher: name: Jiangxi Province ChengZhu Environmental Engineering Company Ltd
Year: 2024

description: DOI: 10.58473/JBS0023     Retrieval from official database: www.crossref.org

 

Liu Huan (2023). 论道教三魂七魄学说与生命起源哲学. Journal of Biological Sciences (ISSN 2958-4035).2023(11). https://doi.org/10.58473/JBS00232024. Copyrights Certificate Registered by Brock Chain Technology: Brock Chain ID (29d89dbc1293ae40a9f6a4218e0992f55b3069aa382fb8851caa351344e2a2d5) ; Registered Time: 2024-01-12 15:39The formally published serials is the printing , and the serials NO. is the month/year when the materials is accessible on this website, authorized by publisher;正式发表的期刊是印刷版《生物科学杂志 (ISSN 2958-4035)》,期刊期号为文章内容在本网站上网年/月,出版人许可自行正式发表。Originality Statement: The originality of this article has been tested and checked by Turnitin (International).Latest revised on 12/01/2024.All Copyrights Reserved.

 

Scilit Database Retrieval URL : https://www.scilit.net/publications/715e0a750dcd3e6d22ceb588af1ec4d9Web of Science Retrieval URL: https://publons.com/wos-op/publon/66151049/

 

ORCID: https://orcid.org/0000-0003-4881-8509
MPEC 2024-N12 : 2024 MX1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 MX1

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Additional file 1 of Bioinformatic analysis of genotype by sequencing (GBS) data with NGSEP
Creators: name: Perea, Claudia
name: Hoz, Juan De La
name: Cruz, Daniel
name: Lobaton, Juan
name: Izquierdo, Paulo
name: Quintero, Juan
name: Raatz, Bodo
name: Duitama, Jorge
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Supplementary figures referred in this manuscript. (PDF 90 kb)
Additional file 2: Table S2. of The association of reduced lung function with blood pressure variability in African Americans: data from the Jackson Heart Study
Creators: name: Booth, John
name: Redmond, Nicole
name: Sims, Mario
name: Shimbo, Daichi
name: Muntner, Paul
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Difference in day-night standard deviation of blood pressure across quartiles forced-expiratory-volume-in-1-second by subgroups. (DOCX 27 kb)
Additional file 2: Figure S1. of Transcriptional regulatory networks controlling woolliness in peach in response to preharvest gibberellin application and cold storage
Creators: name: Pegoraro, Camila
name: Tadiello, Alice
name: Girardi, César
name: Fábio Chaves
name: Quecini, Vera
name: Oliveira, Antonio Costa De
name: Trainotti, Livio
name: Rombaldi, Cesar
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: Expression validation of microarray genes by RT-qPCR for cold stored and GA treated fruits. Represented genes are functionally classified to cell wall metabolism (EXP - ppa014051m, PME - ppa005976m and PG - ppa025787m), photosynthesis light reactions (PSBY - ppa011725m, PSI-L - ppa011229m and PSI-RC - ppa010953m) and redox metabolism (APX - ppa010426m, SOD - ppa009729m and GPX - ppa011681m). Values correspond to the mean ± SD (n = 3). (PDF 127 kb)
Additional file 1: of Predictors of mortality in a cohort of tuberculosis/HIV co-infected patients in Southwest Ethiopia
Creators: name: Hailay Gesesew
name: Birtukan Tsehayneh
name: Desalegn Massa
name: Amanuel Gebremedhin
name: Hafte Kahsay
name: Mwanri, Lillian
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Multilingual abstract in the five official working languages of the United Nation. (PDF 782 kb)
Additional file 2: Table S2. of Outcomes of a four-year specialist-taught physical education program on physical activity: a cluster randomized controlled trial, the LOOK study
Creators: name: Telford, Rohan
name: Olive, Lisa
name: Cochrane, Thomas
name: Davey, Rachel
name: Telford, Richard
Publisher: name: Figshare
Year: 2016
Subjects: subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Median values and Interquartile range for the proportion of lesson time and minutes per lesson spent on differing lesson content. (DOCX 31 kb)