cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Translating a child care based intervention for online delivery: development and randomized pilot study of Go NAPSACC
Creators: name: Burney, Regan
name: Mazzucca, Stephanie
name: Ward, Dianne
name: Vaughn, Amber
Publisher: name: BioMed Central
Year: 2017

description: Abstract Background As part of childhood obesity prevention initiatives, Early Care and Education (ECE) programs are being asked to implement evidence-based strategies that promote healthier eating and physical activity habits in children. Translation of evidence-based interventions into real world ECE settings often encounter barriers, including time constraints, lack of easy-to-use tools, and inflexible intervention content. This study describes translation of an evidence-based program (NAPSACC) into an online format (Go NAPSACC) and a randomized pilot study evaluating its impact on centers’ nutrition environments. Methods Go NAPSACC retained core elements and implementation strategies from the original program, but translated tools into an online, self-directed format using extensive input from the ECE community. For the pilot, local technical assistance (TA) agencies facilitated recruitment of 33 centers, which were randomized to immediate (intervention, n = 18) or delayed (control, n = 15) access groups. Center directors were oriented on Go NAPSACC tools by their local TA providers (after being trained by researchers), after which they implemented Go NAPSACC independently with minimal TA support. The Environment and Policy Assessment and Observation instrument (self-report), collected prior to and following the 4-month intervention period, was used to assess impact on centers’ nutrition environments. Process data were also collected from a sample of directors and all TA providers to evaluate program usability and implementation. Results Demographic characteristics of intervention and control centers were similar. Two centers did not complete follow-up measures, leaving 17 intervention and 14 control centers in the analytic sample. Between baseline and follow-up, intervention centers improved overall nutrition scores (Cohen’s d effect size = 0.73, p = 0.15), as well as scores for foods (effect size = 0.74, p = 0.16), beverages (effect size = 0.54, p = 0.06), and menus (effect size = 0.73, p = 0.08), but changes were not statistically significant. Conclusions Core elements of NAPSACC were effectively translated into online tools and successfully implemented by center directors. Results suggest that the online program may have retained its ability to drive change in centers’ nutrition environments using a streamlined, self-directed, and flexible implementation approach. Results need to be confirmed in a larger more definitive trial. Trial registration NCT02889198 (retrospectively registered).
Nuclear excitations as coupled one and two random--phase--approximation modes
Creators: name: Gambacurta, D.
name: Catara, F.
name: Grasso, M.
name: Sambataro, M.
name: Andrés, M. V.
name: Lanza, E. G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We present an extension of the random--phase approximation (RPA) where the RPA phonons are used as building blocks to construct the excited states. In our model, that we call double RPA (DRPA), we include up to two RPA phonons. This is an approximate and simplified way, with respect to the full second random--phase approximation (SRPA), to extend the RPA by including two particle--two hole configurations. Some limitations of the standard SRPA model, related to the violation of the stability condition, are not encountered in the DRPA. We also verify in this work that the energy--weighted sum rules are satisfied. The DRPA is applied to low--energy modes and giant resonances in the nucleus $^{16}$O. We show that the model (i) produces a global downwards shift of the energies with respect to the RPA spectra; (ii) provides a shift that is however strongly reduced compared to that generated by the standard SRPA. This model represents an alternative way of correcting for the SRPA anomalous energy shift, compared to a recently developed extension of the SRPA, where a subtraction procedure is applied. The DRPA provides results in good agreeement with the experimental energies, with the exception of those low--lying states that have a dominant two particle--two hole nature. For describing such states, higher--order calculations are needed.
description: 9 pages, 13 figures
A bioactive chalcone from the aerial parts of Indigofera conferta Gillet
Creators: name: Isah, Maryam
name: Murtala, Salima
name: Abdullahi, Sakynah Musa
name: Hamza, Asmau Nasiru
name: Tajuddeen, Nasir
name: Dauda, Mu’ammar Lawal
name: Mzozoyana, Vuyisa
name: Musa, Aliyu Muhammad
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences

description: Ethnobotanical information indicates that Indigofera conferta is used in northern Nigeria for the management of poisonous snakebites and the methanol extract was previously reported to have antivenin activity. In this study, we report the isolation of an oxyprenylated bioactive secondary metabolite; 2',4'- dihydroxy-4-prenyloxychalcone from the chloroform fraction of the aerial parts of the plant’s methanol extract and the in vivo evaluation of the compound against Naja nigricollis venom. The compound has demonstrated significant (p < 0.05) and dose-dependent antivenin activity against LD99 Naja nigricollis venom. At a dose of 10 mg/kg, the compound protected 60% of the animals tested from death. The observed activity lends credence to the traditional use of the plant in the management of snake bites in northern Nigeria. The compound, 2',4'- dihydroxy-4-prenyloxychalcone, could also serve as a lead in the development of novel antisnake venom agents.
Farrell-Jones spheres and inertia groups of complex projective spaces
Creators: name: Kasilingam, Ramesh
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57R60, 57C24, 57R55, 53C56

description: We introduce and study a new class of homotopy spheres called Farrell-Jones spheres. Using Farrell-Jones sphere we construct examples of closed negatively curved manifolds $M^{2n}$, where $n=7$ or $8$, which are homeomorphic but not diffeomorphic to complex hyperbolic manifolds, thereby giving a partial answer to a question raised by C.S. Aravinda and F.T. Farrell. We show that every exotic sphere not bounding a spin manifold (Hitchin sphere) is a Farrell-Jones sphere. We also discuss the relationship between inertia groups of $\mathbb{C}\mathbb{P}^n$ and Farrell-Jones spheres.
Multi-level modeling of social factors and preterm delivery in Santiago de Chile
Creators: name: Kaufman, Jay S.
Publisher: name: BioMed Central Ltd
Year: 2008

description: Abstract Background Birth before the 37th week of gestation (preterm birth) is an important cause of infant and neonatal mortality, but has been little studied outside of wealthy nations. Chile is an urbanized Latin American nation classified as "middle-income" based on its annual income per capita of about $6000. Methods We studied the relations between maternal social status and neighborhood social status on risk of preterm delivery in this setting using multilevel regression analyses of vital statistics data linked to geocoded decennial census data. The analytic data set included 56,970 births from 2004 in the metropolitan region of Santiago, which constitutes about 70% of all births in the study area and about 25% of all births in Chile that year. Dimensionality of census data was reduced using principal components analysis, with regression scoring to create a single index of community socioeconomic advantage. This was modeled along with years of maternal education in order to predict preterm birth and preterm low birthweight. Results Births in Santiago displayed an advantaged pattern of preterm risk, with only 6.4% of births delivering before 37 weeks. Associations were observed between risk of outcomes and individual and neighborhood factors, but the magnitudes of these associations were much more modest than reported in North America. Conclusion While several potential explanations for this relatively flat social gradient might be considered, one possibility is that Chile's egalitarian approach to universal prenatal care may have reduced social inequalities in these reproductive outcomes.
Bubble and Skyrmion Crystals in Frustrated Magnets with Easy-Axis Anisotropy
Creators: name: Hayami, Satoru
name: Lin, Shi-Zeng
name: Batista, Cristian D.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We clarify the conditions for the emergence of multiple-${\bf Q}$ structures out of lattice and easy-axis spin anisotropy in frustrated magnets. By considering magnets whose exchange interaction has multiple global minima in momentum space, we find that both types of anisotropy stabilize triple-${\bf Q}$ orderings. Moderate anisotropy leads to a magnetic field-induced skyrmion crystal, which evolves into a bubble crystal for increasing spatial or spin anisotropy. The bubble crystal exhibits a quasi-continuous (devil's staircase) temperature dependent ordering wave-vector, characteristic of the competition between frustrated exchange and strong easy-axis anisotropy.
description: 9 pages, 10 figures
Using Emergency Department-Based Inception Cohorts to Determine Genetic Characteristics Associated with Long Term Patient Outcomes after Motor Vehicle Collision: Methodology of the CRASH Study
Creators: name: McLean, Samuel A
name: Soward, April
name: Bortsov, Andrey V
name: Ballina, Lauren
name: Platts-Mills, Timothy
Publisher: name: BioMed Central Ltd
Year: 2011

description: Abstract Background Persistent musculoskeletal pain and psychological sequelae following minor motor vehicle collision (MVC) are common problems with a large economic cost. Prospective studies of pain following MVC have demonstrated that demographic characteristics, including female gender and low education level, and psychological characteristics, including high pre-collision anxiety, are independent predictors of persistent pain. These results have contributed to the psychological and social components of a biopsychosocial model of post-MVC pain pathogenesis, but the biological contributors to the model remain poorly defined. Recent experimental studies indicate that genetic variations in adrenergic system function influence the vulnerability to post-traumatic pain, but no studies have examined the contribution of genetic factors to existing predictive models of vulnerability to persistent pain. Methods/Design The Project CRASH study is a federally supported, multicenter, prospective study designed to determine whether variations in genes affecting synaptic catecholamine levels and alpha and beta adrenergic receptor function augment social and psychological factors in a predictive model of persistent musculoskeletal pain and posttraumatic stress disorder (PTSD) following minor MVC. The Project CRASH study will assess pain, pain interference and PTSD symptoms at 6 weeks, 6 months, and 1 year in approximately 1,000 patients enrolled from 8 Emergency Departments in four states with no-fault accident laws. Discussion The results from this study will provide insights into the pathophysiology of persistent pain and PTSD following MVC and may serve to improve the ability of clinicians and researchers to identify individuals at high risk for adverse outcomes following minor MVC.
Perspectives on the challenges and successes of school-based nutrition programs in Canada: a scoping review protocol
Creators: name: Quibrantar, Selina
name: Malik, Vasanti
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Public Health
subject: Nutrition
subject: Medicine and Health Sciences
subject: Life Sciences

description: This is a protocol for a scoping review of perspectives on the challenges and successes of school-based nutrition programs in Canada. This review will aim to answer the following questions: 1. What are the challenges and successes regarding school-based nutrition programs in Canada? 2. Whose perspectives do these challenges and successes concern (parents/caregivers, children, school administrators, teachers, volunteers, stakeholders)? 3. What types of school-based nutrition programs do these challenges and successes concern (snack program, lunch program, breakfast program)? Given the demand for a national school food program in Canada, research is necessary to ensure the maximum effectiveness of program design and delivery. An important angle to examine is the perspectives of key groups and stakeholders, as they play a principal role in the function of existing programs. The objectives of this scoping review are to: 1. Discover the challenges and successes of school-based nutrition programs in Canada grounded in the perspectives of different groups 2. Determine whose perspectives are represented in the literature 3. Determine what challenges and successes are associated with different types of school-nutrition programs Through this scoping review, we hope to recognize the challenges and successes embedded in the experiences of key groups and stakeholders, to define key domains that can be used to direct future studies and inform a framework for a national school food policy.
Marlow Moss (1889-1958)
Creators: name: Howarth, Lucy Harriet Amy
Publisher: name: University of Plymouth
Year: 2008

description: Merged with duplicate record 10026.1/831 on 15.02.2017 by CS (TIS)
description: This thesis is the first full-length academic study of Marlow Moss in English. The methodology of this research has been to combine biographical, historical, and analytical approaches, and the chapters (a literature review; a biographical account; an examination of gender I identity issues; a European art historical perspective; a British art historical perspective; and a critical analysis of Moss's oeuvre), function as thematic lenses through which to view Moss. It could seem that Moss's historical position, a British artist working in Europe and a European-influenced artist working in England, should have secured her a more prominent role in the history of British Constructive Art. Moss's subsequent neglect provokes questions about the construction of that history. The impetus of this research has been the retrieval of a lost personality in British and European Modernist Art. This thesis represents the most complete account of Moss's life and work to date, and the most sustained examination of her aesthetic. Gathered in the Catalogue Raisonne in appendix to this thesis are over a hundred recorded works by Moss, with images whenever possible, with all currently available information and details of provenance. Also accompanying this thesis are reproductions of photographs, of Moss and of her works, hitherto inaccessible in private collections. This research has gathered and collated extensive archival material, ranging from contemporary reviews of Moss exhibitions, to all known manuscript material relating to Moss, including unpublished letters such as those held in the Paule Vezelay Collection of the Tale Archives, which remain un-catalogued at the time of writing. Moss's relationship with Mondrian, the focus of much previous research, is addressed and clarified in this thesis. The significance of Moss's connections to Paris, the Academie Moderne and Leger, and Abstraction-Creation, and her relationship to her contemporaries, particularly Georges Vantongerloo and Max Bill, are traced. Her position in British art history is mapped, with particular attention to her exhibitions in London during the fifties. Beyond establishing Moss's absence from art historical narratives, and examining the circumstances of her neglect, this thesis primarily seeks to retrieve the position she did occupy, by exploring her working aesthetic and situating it within a specific historical and theoretical context. This context includes Moss's sexuality and the questions it raises for a critical evaluation of her achievement. Although both feminist and Queer Theorist paradigms are pertinent to this research, and are indeed included in this study, Moss is found to problematise existent theoretical categories. Moss's neglect may thus be explained by her lack of fit with prevalent historical and theoretical approaches to Constructivism, to British Modernism, and to the gendering of arts practice.
A new sesquiterpene lactone from the leaves of Panax vietnamensis Ha et Grushv. (Vietnamese ginseng)
Creators: name: Le, Hoang Khang
name: Phan, Thanh Tung
name: Nguyen, Thi My Nuong
name: Nguyen, Thanh Chung
name: Tran, Cong Luan
name: Hansen, Poul Erik
name: That, Quang Ton
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: Plant Biology
subject: Virology

description: Panax vietnamensis (Vietnamese ginseng, Ngoc Linh ginseng) is an endemic Panax species of Vietnam. From the methanol extract of the leaves of Panax vietnamensis, five compounds (1–5) were isolated, including one new sesquiterpene lactone such as panaxolide (1) and four known compounds. The structures of the compounds (1-5) were elucidated by spectral techniques such as 1 D NMR (1H NMR, 13C NMR), 2 D NMR (COSY, HSQC, HMBC, NOESY) and mass spectrometry. The absolute configuration of 1 was determined based on the Cotton effects in the CD spectrum. All of the five compounds were screened for their in vitro growth inhibitory activities against cancerous cells (HepG2) and normal cells (fibroblast) using the SRB assay. Panaxolide (1) showed the highest potential for the growth inhibition of cancerous cells HepG2 with the IC50 values of 63.8 μM.
IMTA Biofloc Production Manual
Creators: name: Poersch, Luis
Publisher: name: Zenodo
Year: 2024

description: This manual was created as part of the WP2 ‘New IMTA value chains and production methods’ of the H2020 All Atlantic Ocean Sustainable, Profitable and Resilient Aquaculture (ASTRAL) project. It provides detailed instructions of the cultivation technique for each of the species trialled at the ASTRAL IMTA labs. Three types of IMTA systems are included in this report, including an open-water IMTA system, a land-based pump ashore system and a IMTA Biofloc system. The ASTRAL species included fed and extractive species of fish, seaweeds, halophytes, molluscs, echinoderms and crustaceans.
CONCEITOS DE GESTÃO E GERÊNCIA DO CUIDADO DE ENFERMAGEM: Revisão de Escopo
Creators: name: Barros, Aurilívia
name: Menegaz, Jouhanna
name: Polaro, Sandra
name: de Lima Trindade, Letícia
name: Santos, José
name: Meschial, William
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Education
subject: Health and Physical Education
subject: Gerenciamento da Prática Profissional; Gestão em Saúde; Organização e Administração; Cuidados de Enfermagem; Enfermagem.
subject: Professional Practice Management; Health Management; Organization and Administration; Nursing care; Nursing.

description: Os termos Gestão e Gerência do Cuidado estão fortemente presentes na realidade dos serviços de saúde, bem como na literatura acadêmica, em estudos nos mais diversos níveis de atenção. Há muitas dúvidas relacionadas à abrangência e diferenciação dos termos Gestão do Cuidado de Enfermagem e Gerência do Cuidado de Enfermagem. Este estudo trata-se de uma revisão de escopo com base no protocolo do Joanna Briggs Institute. O período da pesquisa deu-se de abril de 2020 a janeiro de 2021. Os artigos pesquisados foram obtidos nas bases LILACS, CINAHL, MEDLINE e SCOPUS sem delimitação de tempo. A amostra foi composta por estudos publicados entre 2007 e 2020, nos idiomas português, inglês e espanhol.
Xylem transcription profiles indicate potential metabolic responses for economically relevant characteristics of Eucalyptus species
Creators: name: Mieczkowski, Piotr
Publisher: name: BioMed Central Ltd
Year: 2013

description: Abstract Background Eucalyptus is one of the most important sources of industrial cellulose. Three species of this botanical group are intensively used in breeding programs: E. globulus, E. grandis and E. urophylla. E. globulus is adapted to subtropical/temperate areas and is considered a source of high-quality cellulose; E. grandis grows rapidly and is adapted to tropical/subtropical climates; and E. urophylla, though less productive, is considered a source of genes related to robustness. Wood, or secondary xylem, results from cambium vascular differentiation and is mostly composed of cellulose, lignin and hemicelluloses. In this study, the xylem transcriptomes of the three Eucalyptus species were investigated in order to provide insights on the particularities presented by each of these species. Results Data analysis showed that (1) most Eucalyptus genes are expressed in xylem; (2) most genes expressed in species-specific way constitutes genes with unknown functions and are interesting targets for future studies; (3) relevant differences were observed in the phenylpropanoid pathway: E. grandis xylem presents higher expression of genes involved in lignin formation whereas E. urophylla seems to deviates the pathway towards flavonoid formation; (4) stress-related genes are considerably more expressed in E. urophylla, suggesting that these genes may contribute to its robustness. Conclusions The comparison of these three transcriptomes indicates the molecular signatures underlying some of their distinct wood characteristics. This information may contribute to the understanding of xylogenesis, thus increasing the potential of genetic engineering approaches aiming at the improvement of Eucalyptus forest plantations productivity.
Patulinervones A and B, two novel α-glucosidase inhibitory spiro-lignans from Melicope patulinervia (Merr. & Chun) C.C. Huang
Creators: name: Vu, Van-Tuan
name: Xu, Qi-Qi
name: Nguyen, Huu Tung
name: Nguyen, Ngoc-Hieu
name: Pham, Giang-Nam
name: Kong, Ling-Yi
name: Luo, Jian-Guang
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences
subject: Virology

description: (±)-Patulinervones A (1) and B (2), two diastereomers of spiro-lignans sharing an unprecedented dimethyl-spiro[furan-2,2′-furo[2,3-b]furan] 5/5/5 tricyclic moiety were isolated from the leaves of Melicope patulinervia (Merr. & Chun) C.C. Huang. Their structures were established by extensive spectroscopic data and electronic circular dichroism (ECD) analyses. The racemates (±)-1 and 2 and their enantiomers exhibited α-glucosidase inhibitory effect with IC50 values range of 10.08 ± 1.24 − 25.58 ± 1.97 µM.
Three new cytotoxic stilbene dimers from paphiopedilum dianthum
Creators: name: Lertnitikul, Nonthalert
name: Liangsakul, Jatupol
name: Jianmongkol, Suree
name: Suttisri, Rutt
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Plant Biology
subject: Virology

description: Three new stilbene dimers, paphiodianthins A-C (1–3), and nine known stilbenes, lignan and flavonoids (4–12) were isolated from the roots and leaves of Paphiopedilum dianthum (Orchidaceae). The structures of new compounds were elucidated from their NMR, HRESIMS and IR spectroscopic data. Cytotoxic activity of all isolated compounds was evaluated by in vitro MTT assay against two human cancer cell lines (MCF-7, Caco-2), doxorubicin-resistant and mitoxantrone-resistant MCF-7 sublines, as well as a normal cell line (NIH/3T3). Stilbenes 1, 3, 10 and 11 were strongly cytotoxic to both cancer cell lines with IC50 values ranging from 0.50 to 4.51 µM. Compounds 1, 10 and 11 were also active against chemotherapy-resistant MCF-7 sublines.
Spin glass induced by infinitesimal disorder in geometrically frustrated kagome lattice
Creators: name: Schmidt, M.
name: Zimmer, F. M.
name: Magalhaes, S. G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We propose a method to study the magnetic properties of a disordered Ising kagome lattice. The model considers small spin clusters with infinite-range disordered couplings and short-range ferromagnetic (FE) or antiferromagnetic interactions. The correlated cluster mean-field theory is used to obtain an effective single-cluster problem. A finite disorder intensity in FE kagome lattice introduces a cluster spin-glass (CSG) phase. Nevertheless, an infinitesimal disorder stabilizes the CSG behavior in the geometrically frustrated kagome system. Entropy, magnetic susceptibility and spin-spin correlation are used to describe the interplay between disorder and geometric frustration (GF). We find that GF plays an important role in the low-disorder CSG phase. However, the increase of disorder can rule out the effect of GF.
description: 9 pages, 5 figures
Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study
Creators: name: Doerschuk, Claire
name: Davis, Sonia
name: O’Neal, Wanda K
name: Carretta, Elizabeth E
name: Anderson, Wayne
name: Couper, David
Publisher: name: BioMed Central Ltd
Year: 2014

description: Abstract Background As a part of the longitudinal Chronic Obstructive Pulmonary Disease (COPD) study, Subpopulations and Intermediate Outcome Measures in COPD study (SPIROMICS), blood samples are being collected from 3200 subjects with the goal of identifying blood biomarkers for sub-phenotyping patients and predicting disease progression. To determine the most reliable sample type for measuring specific blood analytes in the cohort, a pilot study was performed from a subset of 24 subjects comparing serum, Ethylenediaminetetraacetic acid (EDTA) plasma, and EDTA plasma with proteinase inhibitors (P100™). Methods 105 analytes, chosen for potential relevance to COPD, arranged in 12 multiplex and one simplex platform (Myriad-RBM) were evaluated in duplicate from the three sample types from 24 subjects. The reliability coefficient and the coefficient of variation (CV) were calculated. The performance of each analyte and mean analyte levels were evaluated across sample types. Results 20% of analytes were not consistently detectable in any sample type. Higher reliability and/or smaller CV were determined for 12 analytes in EDTA plasma compared to serum, and for 11 analytes in serum compared to EDTA plasma. While reliability measures were similar for EDTA plasma and P100 plasma for a majority of analytes, CV was modestly increased in P100 plasma for eight analytes. Each analyte within a multiplex produced independent measurement characteristics, complicating selection of sample type for individual multiplexes. Conclusions There were notable detectability and measurability differences between serum and plasma. Multiplexing may not be ideal if large reliability differences exist across analytes measured within the multiplex, especially if values differ based on sample type. For some analytes, the large CV should be considered during experimental design, and the use of duplicate and/or triplicate samples may be necessary. These results should prove useful for studies evaluating selection of samples for evaluation of potential blood biomarkers.
Novel insight into Chronic Inflammatory Demyelinating Polineuropathy in APECED syndrome: molecular mechanisms and clinical implications in children
Creators: name: Su, Maureen
Publisher: name: BioMed Central
Year: 2017

description: Abstract Autoimmune polyendocrinopathy-candidiasis-ectodermal-dystrophy (APECED) is a rare primary immunodeficiency disorder typically caused by homozygous AIRE gene mutation. It is characterized by the association of multiple autoimmune diseases, with a classical triad including chronic mucocutaneous candidiasis, hypoparathyroidism and adrenocortical failure. Its clinical spectrum has significantly enlarged in the last years with the apparence of new entities. One of these novel manifestations is the chronic inflammatory demyelinating polineuropathy (CIDP), that is characterized by involvement of peripheral nervous system, with nerve demyelination, progressive muscular weakness of both arms and legs and sensory loss. The identification of myelin protein zero as an important autoantigen (Ag) in CIDP may suggest the development of Ag-based therapies, such as Ag-specific DNA vaccination or infusion of Ag-coupled cells.
Casimir free energy of metallic films: Discriminating between Drude and plasma model approaches
Creators: name: Klimchitskaya, G. L.
name: Mostepanenko, V. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We investigate the Casimir free energy of a metallic film either sandwiched between two dielectric plates or in vacuum. It is shown that even for a thin film of several tens of nanometer thickness the Casimir free energy and pressure calculated with the Lifshitz theory using the Drude model and the plasma model approaches take significantly different values and can be easily discriminated. According to our results, the classical limit is already achieved for films of about 100\,nm thickness if the Drude model approach is used in calculations. In this case the classical expressions for the Casimir free energy and pressure are common for both configurations considered. If the plasma model approach is used, the classical limit is not achieved for any film thickness. Instead, the Casimir free energy and pressure are decreasing exponentially to zero. When the plasma frequency goes to infinity, the Casimir free energy obtained using the Drude model approach goes to a nonzero limit in contradiction with expectations. If the plasma model approach is used the free energy of metallic film goes to zero in the limit of infinitely large plasma frequency. All analytic results are accompanied by numerical computations performed for a Au film and sapphire plates. The possibilities to observe the predicted effects discriminating between the Drude and plasma model approaches are discussed.
description: 24 pages, 6 figures; to appear in Phys. Rev. A
CD4 count at presentation for HIV care in the United States and Canada: Are those over 50 years more likely to have a delayed presentation?
Creators: name: Napravnik, Sonia
name: Eron, Joseph
Publisher: name: BioMed Central Ltd
Year: 2010

description: Abstract: We assessed CD4 count at initial presentation for HIV care among ≥50-year-olds from 1997-2007 in 13 US and Canadian clinical cohorts and compared to <50-year-olds. 44,491 HIV-infected individuals in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) were included in our study. Trends in mean CD4 count (measured as cells/mm3) and 95% confidence intervals ([,]) were determined using linear regression stratified by age category and adjusted for gender, race/ethnicity, HIV transmission risk and cohort. From 1997-2007, the proportion of individuals presenting for HIV care who were ≥50-years-old increased from 17% to 27% (p-value < 0.01). The median CD4 count among ≥50 year-olds was consistently lower than younger adults. The interaction of age group and calendar year was significant (p-value <0.01) with both age groups experiencing modest annual improvements over time (< 50-year-olds: 5[4 , 6] cells/mm3; ≥50-year-olds: 7[5 , 9] cells/mm3), after adjusting for sex, race/ethnicity, HIV transmission risk group and cohort; however, increases in the two groups were similar after 2000. A greater proportion of older individuals had an AIDS-defining diagnosis at, or within three months prior to, first presentation for HIV care compared to younger individuals (13% vs. 10%, respectively). Due to the increasing proportion, consistently lower CD4 counts, and more advanced HIV disease in adults ≥50-year-old at first presentation for HIV care, renewed HIV testing efforts are needed.
Open Call for Innovation, publication of open call offerings, rules for participation, criteria for selection and grants offered
Creators: name: Sciacca, Eva
name: Nomikou, Paraskevi
name: Lampidou, Danai
name: Martinez, Daniel
name: Ramirez, Javier
name: Rapsomanikis, Spyridon
Publisher: name: Zenodo
Year: 2021
Subjects: innovation management
open innovation
business innovation cases
user involvement

description: NEANIAS Project partners have been driving the co-design and delivery of 10+ innovative thematic services, derived from the state-of-the art research assets and practices in hopes of overcoming emerging challenges; like bringing together actors from several disciplines (astrophysics, planetary, ocean, climate, archaeology, geology, computer science and more) to expand the vision of the project on business cases as a result of Open Innovation Calls. There are two Open Calls organised in the framework of the NEANIAS project, to invite potential external end-users in testing, and integrating NEANIAS services of all thematic sectors, and provide valuable feedback for NEANIAS partners on creating new business perspectives. The Open innovation method utilised in NEANIAS considers the target thematic areas of the services, including Start-ups, Established private companies from diverse industries (SMEs / Multinationals), and Groups of individual researchers / innovators of up to 3 members. As a result of the intense activities, the First Open Call is closed successfully, with 21 applications, who applied to utilize and integrate NEANIAS services to create new business cases. Organizing and implementing the First NEANIAS Open Call was a complex process, and this deliverable summarizes all preparation and implementation activities, including communication.
השפעת שימוש באפליקציות היכרויות וחשיפה לתכנים רומנטיים על אידיאולוגיה רומנטית​
Creators: name: Aloni, Yuval
name: Amit, Gili
name: Beirav, Shani
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Dating apps
subject: Romantic Beliefs

description: זוהי ההרשמה מראש למחקר שלנו במסגרת הקורס פסיכולוגיה ניסויית
Historical changes in thermoregulatory traits of alpine butterflies reveal complex ecological and evolutionary responses to recent climate change
Creators: name: MacLean, Heidi J
name: Kingsolver, Joel
Publisher: name: BioMed Central
Year: 2016

description: Abstract Background Trait evolution and plasticity are expected to interactively influence responses to climate change, but rapid changes in and increased variability of temperature may limit evolutionary responses. We use historical specimens to document changes in the size and thermoregulatory traits of a montane butterfly, Colias meadii, in Colorado, USA over the past 60 years (1953–2012). We quantify forewing wing length, ventral wing melanin that increases solar absorption, and the length of thorax setae that reduces convective heat loss. Results The mean of all three traits has increased during this time period despite climate warming. Phenological shifts may have extended the active season earlier at low elevations and later at high elevations, increasing exposure to cool temperatures and selecting for increases in thermoregulatory traits. Fitness increases at higher elevations due to warming could also increase thermoregulatory traits. Warmer temperatures during pupal development and later flight dates in the season are associated with decreased wing melanin, indicating a role of phenotypic plasticity in historical trait changes. Conclusions Phenotypic shifts result from a complex interplay of ecological and evolutionary responses to climate change. Environmental variability within and across seasons can limit the evolutionary responses of populations to increasing mean temperatures during climate change.
Inertia groups and smooth structures of $(n-1)$-connected $2n$-manifolds
Creators: name: Kasilingam, Ramesh
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57R55, 57R60, 57R50, 57R65

description: Let $M^{2n}$ denote a closed $(n-1)$-connected smoothable topological $2n$-manifold. We show that the group $\mathcal{C}(M^{2n})$ of concordance classes of smoothings of $M^{2n}$ is isomorphic to the group of smooth homotopy spheres $\overlineΘ_{2n}$ for $n=4$ or $5$, the concordance inertia group $I_c(M^{2n})=0$ for $n=3$, $4$, $5$ or $11$ and the homotopy inertia group $I_h(M^{2n})=0$ for $n=4$. On the way, following Wall's approach \cite{Wal67} we present a new proof of the main result in \cite{KS07}, namely, for $n=4$, $8$ and $H^{n}(M^{2n};\mathbb{Z})\cong \mathbb{Z}$, the inertia group $I(M^{2n})\cong \mathbb{Z}_2$. We also show that, up to orientation-preserving diffeomorphism, $M^{8}$ has at most two distinct smooth structures; $M^{10}$ has exactly six distinct smooth structures and then show that if $M^{14}$ is a $π$-manifold, $M^{14}$ has exactly two distinct smooth structures.
Pre-Hawking radiation may allow for reconstruction of the mass distribution of the collapsing object
Creators: name: Dai, De-Chang
name: Stojkovic, Dejan
Publisher: name: arXiv
Year: 2016
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Hawking radiation explicitly depends only on the black hole's total mass, charge and angular momentum. It is therefore generally believed that one cannot reconstruct the information about the initial mass distribution of an object that made the black hole. However, instead of looking at radiation from a static black hole, we can study the whole time-dependent process of the gravitational collapse, and pre-Hawking radiation which is excited because of the time-dependent metric. We compare radiation emitted by a single collapsing shell with that emitted by two concentric shells of the equivalent total mass. We calculate the gravitational trajectory and the momentum energy tensor. We show that the flux of energy emitted during the collapse by a single shell is significantly different from the flux emitted by two concentric shells of the equivalent total mass. When the static black hole is formed, the fluxes become indistinguishable. This implies that an observer studying the flux of particles from a collapsing object could in principle reconstruct information not only about the total mass of the collapsing object, but also about the mass distribution.
description: 4 figures, 5 page, accepted by PLB
The effectiveness of interventions to improve uptake and retention of HIV-infected pregnant and breastfeeding women and their infants in prevention of mother-to-child transmission care programs in low- and middle-income countries: protocol for a systematic review and meta-analysis
Creators: name: Rosenberg, Nora E
name: Hosseinipour, Mina
Publisher: name: BioMed Central
Year: 2015

description: Abstract Background Despite recent improvements, uptake and retention of mothers and infants in prevention of mother-to-child transmission (PMTCT) services remain well below target levels in many low- and middle-income countries (LMICs). Identification of effective interventions to support uptake and retention is the first step towards improvement. We aim to complete a systematic review and meta-analysis to evaluate the effectiveness of interventions at the patient, provider or health system level in improving uptake and retention of HIV-infected mothers and their infants in PMTCT services in LMICs. Methods/Design We will include studies comparing usual care or no intervention to any type of intervention to improve uptake and retention of HIV-infected pregnant or breastfeeding women and their children from birth to 2 years of age attending PMTCT services in LMICs. We will include randomized controlled trials (RCTs), cluster RCTs, non-randomized controlled trials, and interrupted time series. The primary outcomes of interest are percentage of HIV-infected women receiving/initiated on anti-retroviral prophylaxis or treatment, percentage of infants receiving/initiated on anti-retroviral prophylaxis, and percentage of women and infants completing the anti-retroviral regimen/retained in PMTCT care. The following databases will be searched from inception: Ovid MEDLINE and EMBASE, The WHO Global Health Library, CAB abstracts, EBM Reviews, CINAHL, HealthSTAR and Web of Science databases, Scopus, PsychINFO, POPLINE, Sociological Abstracts, ERIC, AIDS Education Global Information System, NLM Gateway, LILACS, Google Scholar, British Library Catalogue, DARE, ProQuest Dissertation & Theses, the New York Academy of Grey Literature, Open Grey, The Cochrane Library, WHO International Clinical Trials Registry, Controlled Clinical Trials, and clinicaltrials.gov. Reference lists of included articles will be hand searched and study authors and content experts contacted to inquire about eligible unpublished or in progress studies. Screening, data abstraction, and risk of bias appraisal using the Cochrane Effective Practice and Organization of Care criteria will be conducted independently by two team members. Results will be synthesized narratively and a meta-analysis conducted using the DerSimonian Laird random effects method if appropriate based on assessment of clinical and statistical heterogeneity. Discussion Our findings will be useful to PMTCT implementers, policy makers, and implementation researchers working in LMICs. Systematic review registration PROSPERO CRD42015020829
Multivariate methods and software for association mapping in dose¿response genome¿wide association studies
Creators: name: McLeod, Howard L.
name: Havener, Tammy
Publisher: name: BioMed Central Ltd
Year: 2012

description: Abstract Background The large sample sizes, freedom of ethical restrictions and ease of repeated measurements make cytotoxicity assays of immortalized lymphoblastoid cell lines a powerful new in vitro method in pharmacogenomics research. However, previous studies may have over‐simplified the complex differences in dose‐response profiles between genotypes, resulting in a loss of power. Methods The current study investigates four previously studied methods, plus one new method based on a multivariate analysis of variance (MANOVA) design. A simulation study was performed using differences in cancer drug response between genotypes for biologically meaningful loci. These loci also showed significance in separate genome‐wide association studies. This manuscript builds upon a previous study, where differences in dose‐response curves between genotypes were constructed using the hill slope equation. Conclusion Overall, MANOVA was found to be the most powerful method for detecting real signals, and was also the most robust method for detection using alternatives generated with the previous simulation study. This method is also attractive because test statistics follow their expected distributions under the null hypothesis for both simulated and real data. The success of this method inspired the creation of the software program MAGWAS. MAGWAS is a computationally efficient, user‐friendly, open source software tool that works on most platforms and performs GWASs for individuals having multivariate responses using standard file formats.
Educação profissional técnica em enfermagem na Rede Federal - protocolo para revisão de escopo
Creators: name: de Jesus, Ludmila
name: Silva, Gilberto
name: Souza, Virgínia
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Other Nursing
subject: Nursing
subject: FOS: Health sciences

description: Protocolo de pesquisa do estudo intitulado Educação profissional técnica em enfermagem na Rede Federal de Educação: uma revisão de escopo.
Supplementary materials for the Data Protection Record of Processing Activities and Privacy Notice generator toolkit by EMBL’s European Bioinformatics Institute
Creators: name: Gonzalez-Ferreiro, Montserrat
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Business
subject: Engineering
subject: Law
subject: FOS: Law
subject: data protection
subject: GDPR
subject: intergovernmental organisations
subject: personal data
subject: privacy notice
subject: record of processing activities
subject: research infrastructures

description: Materials to complement the article Data Protection Record of Processing Activities and Privacy Notice generator toolkit by EMBL's European Bioinformatics Institute. Templates for creating questionnaires to collect all the necessary data to generate Records of Processing Activities (as a data controller or as a data processor) privacy notices (when personal data is collected directly from a data subject or when personal data is not directly provided by a data subject).
Intermode-coupling modulation in the fermion-boson model: heating effects in the BCS regime
Creators: name: Plata, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Heating induced by an oscillating modulation of the interaction strength in an atomic Fermion pair condensate is analyzed. The coupled fermion-boson model, generalized by incorporating a time-dependent intermode coupling through a magnetic Feshbach resonance, is applied. The dynamics is analytically characterized in a perturbative scheme. The results account for experimental findings which have uncovered a damped and delayed response of the condensate to the modulation. The delay is due to the variation of the quasiparticle energies and the subsequent relaxation of the condensate. The detected damping results from the excitations induced by a nonadiabatic modulation: for driving frequencies larger than twice the pairing gap, quasiparticles are generated, and, consequently, heating sets in.
Constraints on hidden photons from current and future observations of CMB spectral distortions
Creators: name: Kunze, Kerstin E.
name: Vazquez-Mozo, Miguel A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A variety of beyond the standard model scenarios contain very light hidden sector U(1) gauge bosons undergoing kinetic mixing with the photon. The resulting oscillation between ordinary and hidden photons leads to spectral distortions of the cosmic microwave background. We update the bounds on the mixing parameter $χ_0$ and the mass of the hidden photon $m_{γ'}$ for future experiments measuring CMB spectral distortions, such as PIXIE and PRISM/COrE. For $10^{-14}\;{\rm eV}\lesssim m_{γ'}\lesssim 10^{-13}\;{\rm eV}$, we find the kinetic mixing angle $χ_0$ has to be less than $10^{-8}$ at 95\% CL. These bounds are more than an order of magnitude stronger than those derived from the COBE/FIRAS data.
description: 9 pages, 3 figures