cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
First-line anti-VEGF plus EGFR-TKI in EGFR-mutant NSCLC : adding the ARTEMIS trial to the puzzle of current evidence
Creators: name: Hafner, Susanne
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Drug development
subject: Lung cancer
subject: Outcomes research
subject: DDC 610 / Medicine & health
subject: Lung; Cancer
subject: Lung neoplasms
subject: Lung neoplasms; Drug therapy
subject: Treatment outcome
subject: Lungenkrebs
subject: Arzneimittelentwicklung

description: In the ARTEMIS-CTONG1509 multicenter phase 3 study recently published in Cancer Cell, Zhou et al. investigate the combination of the EGFR tyrosine kinase inhibitor (TKI) erlotinib and anti-angiogenic bevacizumab in treatment-naive Chinese patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC).1 The primary endpoint of progression-free survival (PFS) was significantly extended from 11.2 months with erlotinib monotherapy to 17.9 months with the combination.
ЕНТЕРОСОРБЦІЯ ЯК ПЕРСПЕКТИВНИЙ МЕТОД УСУНЕННЯ ПОРУШЕНЬ В УМОВАХ ІНДУКОВАНОГО КАНЦЕРОГЕНЕЗУ
Creators: name: Качур Оксана Ігорівна
name: Фіра Людмила Степанівна
name: Лихацький Петро Григорович
Publisher: name: Colloquium-journal
Year: 2020
Subjects: 1
2-диметилгідразин
аланінамінотрансфераза
аспартатамінотрансфераза
лужна фосфатаза
сечовина
АУТ

description: Метою даного дослідження було дослідити сорбційну активність вуглецевого ентеросорбенту АУТ при аденокарциномі товстої кишки. Для моделювання канцерогенезу 70 щурам протягом 30 тижнів вводили 1,2-диметилгідразин (ДМГ) в дозі 7,2 мг/кг. Піддослідні тварини були розділені на 3 групи: І контроль, ІІ уражені щурі, ІІІ тварини, яким після 30-тижневого введення ДМГ, проводили ентеросорбційну терапію. Виявлено, що тривале введення канцерогену супроводжується порушенням цілісності клітинних мембран, про що свідчить підвищення активності органоспецифічних ензимів у сироватці крові. Після 21-денної ентеросорційної терапії вказані показники покращилися. Отримані результати підтвердили позитивний вплив сорбенту АУТ на показники цитолізу в ураженому організмі, що може бути зумовлено його сорбтивними властивостями і зменшенням кількості ендогенних токсинів, що чинять деструктивний вплив на плазматичні мембрани клітин.
Supplementary Tables 1-6 on additional statistical analyses. Table S1: Proportion of pitcher buds (response) with plant age as a predictor instead of proportion of adult pitchers. Table S2: C/N with plant age. Table S3: Total N with proportion adult pitchers. Table S4: Total N with plant age. Table S5: 15N with proportion adult pitchers. Table S6: 15N with plant age.
Creators: name: Lymbery, Samuel J.
name: Didham, Raphael K.
name: Hopper, Stephen D.
name: Simmons, Leigh W.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Carnivorous plants allocate more resources to carnivorous structures under nutrient-limited conditions, and relative investment can also be influenced by animals (infauna) that live in association with these plants and feed on their prey. We investigated these effects within a population of the pitcher plant Cephalotus follicularis containing varying densities of larvae of the fly Badisis ambulans. For plants with a relatively high proportion of adult pitchers, increasing larval density was associated with lower relative leaf allocation to new pitcher buds. For plants with relatively few adult pitchers, however, there was greater relative leaf allocation to pitcher buds with increasing larval density. In a field experiment, there was no significant effect of experimental larval presence or absence on the change in carbon-to-nitrogen (C/N) ratio of plants. Although the direction of the correlation between B. ambulans larvae and relative investment in carnivorous and non-carnivorous structures depends on the relative number of mature structures, whether the larvae enhance or reduce nutrient stress under different conditions remains unclear. The change in C/N was, however, less variable for pitchers that contained larvae, suggesting a stabilizing effect. Eighteen of 52 experimental pitchers were damaged by an unknown species, causing the pitcher fluid to drain. These pitchers were significantly more likely to survive if they contained larvae. These results suggest that the relationship between infauna and host varies with the initial resource status and environmental context of the host plant.
ГЕОЛОГИЧЕСКОЕ ПРОШЛОЕ И НАСТОЯЩЕЕ МАГНИТНЫХ ПОЛЮСОВ ЗЕМЛИ
Creators: name: Андросова Надежда Константиновна
name: Баранова Татьяна Игоревна
name: Семыкина Дарья Владимировна
Publisher: name: Colloquium-journal
Year: 2020
Subjects: северный магнитный полюс
магнитное поле
экскурс полюсов
инверсия
магматизм
модели магнитного поля.

description: В статье отражена краткая история открытия северного магнитного полюса. Рассмотрено перемещение магнитных полюсов: смещение и возвращение полюса (экскурс полюсов) и разворот (инверсия). Представлена информация о международном мониторинге, который проводится в обсерваториях и с околоземных орбит. Дан анализ обновленной Всемирной магнитной модели 2020.
Wildlife gut microbiomes of sympatric generalist species respond differently to anthropogenic landscape disturbances
Creators: name: Heni, Alexander Christoph
name: Fackelmann, Gloria
name: Eibner, Georg
name: Kreinert, Swetlana
name: Schmid, Julian
name: Schwensow, Nina Isabell
name: Wiegand, Jonas
name: Wilhelm, Kerstin Andrea
name: Sommer, Simone
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Gut microbiome
subject: Phylogenetics
subject: Anthropogenic disturbance
subject: Proechimys semispinosus
subject: Philander opossum
subject: Panama
subject: DDC 710 / Landscaping & area planning
subject: Phylogeny
subject: Landscape ecology
subject: Didelphis marsupialis
subject: Philander (Mammals)
subject: Gastrointestinal Microbiome
subject: Phylogenetik
subject: Landschaftsökologie
subject: Nordamerikanisches Opossum

description: Background Human encroachment into nature and the accompanying environmental changes are a big concern for wildlife biodiversity and health. While changes on the macroecological scale, i.e. species community and abundance pattern, are well documented, impacts on the microecological scale, such as the host’s microbial community, remain understudied. Particularly, it is unclear if impacts of anthropogenic landscape modification on wildlife gut microbiomes are species-specific. Of special interest are sympatric, generalist species, assumed to be more resilient to environmental changes and which often are well-known pathogen reservoirs and drivers of spill-over events. Here, we analyzed the gut microbiome of three such sympatric, generalist species, one rodent (Proechimys semispinosus) and two marsupials (Didelphis marsupialis and Philander opossum), captured in 28 study sites in four different landscapes in Panama characterized by different degrees of anthropogenic disturbance. Results Our results show species-specific gut microbial responses to the same landscape disturbances. The gut microbiome of P. semispinosus was less diverse and more heterogeneous in landscapes with close contact with humans, where it contained bacterial taxa associated with humans, their domesticated animals, and potential pathogens. The gut microbiome of D. marsupialis showed similar patterns, but only in the most disturbed landscape. P. opossum, in contrast, showed little gut microbial changes, however, this species’ absence in the most fragmented landscapes indicates its sensitivity to long-term isolation. Conclusion These results demonstrate that wildlife gut microbiomes even in generalist species with a large ecological plasticity are impacted by human encroachment into nature, but differ in resilience which can have critical implications on conservation efforts and One Health strategies.
Grant proposal: Improving the visibility of scholarly software work
Creators: name: Impactstory Team
name: Howison, James
Publisher: name: figshare
Year: 2016
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences
subject: 80306 Open Software
subject: Computer Software
subject: Science Policy

description: Grant submitted to the Alfred P. Sloan Foundation. From the grant summary:
"Our goal is to improve software in scholarship (science, engineering, and the humanities) by raising the visibility of software work as a contribution in the literature, thus improving incentives for software work in scholarship."
Budget pages (22-25) have been removed at the request of JH.
It takes more than a good camera : which factors contribute to differences between face-to-face interviews and videoconference interviews regarding performance ratings and interviewee perceptions?
Creators: name: Basch, Johannes M.
name: Melchers, Klaus G.
name: Kurz, Anja
name: Krieger, Maya
name: Miller, Linda
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Technology-mediated interviews
subject: Impression management
subject: Social presence
subject: Privacy concerns
subject: Job interviews
subject: Applicant reactions
subject: DDC 150 / Psychology
subject: Employment interviewing
subject: Social psychology
subject: Personnel selection
subject: Interview
subject: Personalauswahl
subject: Interview
subject: Sozialpsychologie

description: Due to technological progress, videoconference interviews have become more and more common in personnel selection. Nevertheless, even in recent studies, interviewees received lower performance ratings in videoconference interviews than in face-to-face (FTF) interviews and interviewees held more negative perceptions of these interviews. However, the reasons for these differences are unclear. Therefore, we conducted an experiment with 114 participants to compare FTF and videoconference interviews regarding interview performance and fairness perceptions and we investigated the role of social presence, eye contact, and impression management for these differences. As in other studies, ratings of interviewees’ performance were lower in the videoconference interview. Differences in perceived social presence, perceived eye contact, and impression management contributed to these effects. Furthermore, live ratings of interviewees’ performance were higher than ratings based on recordings. Additionally, videoconference interviews induced more privacy concerns but were perceived as more flexible. Organizations should take the present results into account and should not use both types of interviews in the same selection stage.
Grant proposal: Improving the visibility of scholarly software work
Creators: name: Impactstory Team
name: Howison, James
Publisher: name: figshare
Year: 2016
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences
subject: 80306 Open Software
subject: Computer Software
subject: Science Policy

description: Grant submitted to the Alfred P. Sloan Foundation. From the grant summary:
"Our goal is to improve software in scholarship (science, engineering, and the humanities) by raising the visibility of software work as a contribution in the literature, thus improving incentives for software work in scholarship."
title: OFROM: interview avec unine15a39m
Creators: name: Delafontaine, François
name: Ehinger, Maude
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.4b412569.v2#8c85dc6550f0de1c3f62f564a074da0c478b761a
Multicentre analysis of hyperglycaemic hyperosmolar state and diabetic ketoacidosis in type 1 and type 2 diabetes
Creators: name: Tittel, S. R.
name: Sondern, K. M.
name: Weyer, M.
name: Pöplau, T.
name: Sauer, B. M.
name: Ludwig, K.-H.
name: Hammer, F.
name: Fröhlich-Reiterer, E.
name: Holl, R. W.
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Hyperglycaemic hyperosmolar state
subject: Acute complication
subject: Metabolic decompensation
subject: Multicentre registry
subject: DDC 610 / Medicine & health
subject: Diabetes mellitus
subject: Diabetes complications
subject: Diabetic ketoacidosis
subject: Diabetes mellitus
subject: Komplikation
subject: Acetonämie

description: Aims To compare diabetes patients with hyperglycaemic hyperosmolar state (HHS), diabetic ketoacidosis (DKA), and patients without decompensation (ND). Methods In total, 500,973 patients with type 1 or type 2 diabetes of all ages registered in the diabetes patient follow-up (DPV) were included. Analysis was stratified by age (≤ / > 20 years) and by manifestation/follow-up. Patients were categorized into three groups: HHS or DKA—during follow-up according to the most recent episode—or ND. Results At onset of diabetes, HHS criteria were met by 345 (68.4% T1D) and DKA by 9824 (97.6% T1D) patients. DKA patients had a lower BMI(-SDS) in both diabetes types compared to ND. HbA1c was higher in HHS/DKA. During follow-up, HHS occurred in 1451 (42.2% T1D) and DKA in 8389 patients (76.7% T1D). In paediatric T1D, HHS/DKA was associated with younger age, depression, and dyslipidemia. Pump usage was less frequent in DKA patients. In adult T1D/T2D subjects, metabolic control was worse in patients with HHS/DKA. HHS and DKA were also associated with excessive alcohol intake, dementia, stroke, chronic kidney disease, and depression. Conclusions HHS/DKA occurred mostly in T1D and younger patients. However, both also occurred in T2D, which is of great importance in the treatment of diabetes. Better education programmes are necessary to prevent decompensation and comorbidities.
Materials
Creators: name: Méndez, Lander
name: Carrasco, José J. Pizarro
name: Amutio, Alberto
name: Pascual, Aitziber
name: Alonso-Arbiol, Itziar
name: Páez, Darío
Publisher: name: OSF Registries
Year: 2020

description: Items that will be used, as well as the survey flow.
Skilled migration: Australia
Creators: name: Shah, Chandra
name: Burke, Gerald
Publisher: name: Monash University
Year: 2016
Subjects: Uncategorized

description: Migration patterns to and from Australia are becoming complex with migration programmes increasingly targeted towards meeting the needs of the labour market and regional development. This paper provides an analysis of the permanent and temporary movements of people to and from Australia in the last three years and their impact on the skilled labour supply in Australia. The paper also provides an analysis of occupational mobility of permanent immigrants. The results are consistent with previously published results of initial downward occupational mobility among immigrants. The consequence of this is wastage of skills which the country can least afford in times of reported skills shortages. Skills wastage can be minimised by making available to newly arrived immigrants appropriate programmes for recognising previously acquired qualifications and occupational licenses; updating occupation-specific skills; and providing up-to-date information on the labour market and its operation. In this respect, the TAFE system in Australia is uniquely placed to play a key role.
Evidence gap on antihyperglycemic pharmacotherapy in frail older adults : A systematic review
Creators: name: Bollig, Claudia
name: Torbahn, Gabriel
name: Bauer, Jürgen
name: Brefka, Simone
name: Dallmeier, Dhayana
name: Denkinger, Michael
name: Eidam, Annette
name: Klöppel, Stefan
name: Zeyfang, Andrej
name: Voigt-Radloff, Sebastian
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Ältere Menschen
subject: Ältere gebrechliche Menschen
subject: Medikamentöse Therapie
subject: Systematisches Review
subject: DDC 610 / Medicine & health
subject: Aged
subject: Frailty
subject: Drug therapy
subject: Systematic review
subject: Alter
subject: Gebrechlichkeit
subject: Diabetes mellitus
subject: Pharmakotherapie

description: Abstract Background Although antihyperglycemic pharmacotherapy in frail older adults with type 2 diabetes mellitus (T2DM) is challenging, recommendations from international guidelines are mainly based on indirect evidence from trials not including frail participants. Objective This systematic review investigated the effectiveness and safety of pharmacotherapy in frail older adults with T2DM. Material and methods Randomized (RCT) and non-randomized prospective clinical trials (non-RCT) were searched in three electronic databases (Medline, Embase, Central) up to October 2018. Trials in older adults with T2DM who were assessed as significantly or severely impaired by defined cut-off scores of assessment instruments on frailty, activities of daily living or physical functional impairment were included. Results Two reviewers independently screened 17,391 references for inclusion and assessed risk of bias with ROBINS‑I. Five non-RCTs and no RCT were identified. Treatment of T2DM without insulin compared to insulin could be associated with increased improvement in cardiac functions in patients with cardiac resynchronization therapy and with decreased falls in frail older women. While better glycemic control with low variability and low HbA1c (hemoglobin A1c) values (<7%) was associated with better maintenance of physical function in community-dwelling older persons, higher HbA1c values (8–8.9%) were associated with a reduction in the composite outcome of death or functional decline in community-dwelling diabetic older adults with need for skilled assistance. Due to serious risk of bias in all studies, results should be considered with caution. Conclusion Well-designed, large-scale RCTs including this important group of patients are required to assess the effectiveness and safety of pharmacotherapy and HbA1c targets.
A morphological study of Romano-British settlements in Westmorland.
Creators: name: Webster, Robert A
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 71, 64-74
description: In the absence of dating evidence or artefacts the following classification (which is also partly a temporal sequence) is proposed: (1) enclosed defensive settlements, (2) enclosed non-defensive settlements, (3) those with an enclosed nucleus and external earthworhs, (4) agglomerated (unenclosed) settlements with curvilinear walls, and (5) agglomerated settlements with rectilinear walls. For two of the most developed (and therefore economically important) sites, Ewe Close and Severals, original plans are unknown. The enclosed settlements seem like the work of pioneering land-takers, and the double-orthostat technique of construction could be a copy of the double timber palisade. Groups 4 and 5 are proposed as daughter-settlements from the pastoral-based Group 2, and Group 3 sites suggest an economy changing from pastoral to arable farming.
NOTES
Creators: name: Zzz--, --
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 88, 239-251
description: Short reports on worked flints, a saddle quern, Roman coins, an ancient road, iron mining and miners' roads above Eskdale and Langdale, and an 18th century shuttle and bobbin.
Increased chitotriosidase 1 concentration following nusinersen treatment in spinal muscular atrophy
Creators: name: Freigang, Maren
name: Steinacker, Petra
name: Wurster, Claudia Diana
name: Schreiber-Katz, Olivia
name: Osmanovic, Alma
name: Petri, Susanne
name: Koch, Jan Christoph
name: Rostásy, Kevin
name: Falkenburger, Björn
name: Ludolph, Albert Christian
name: Otto, Markus
name: Hermann, Andreas
name: Günther, René
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: SMA
subject: Chitotriosidase 1
subject: Biomarker
subject: Nusinersen
subject: ASO
subject: CEREBROSPINAL-FLUID
subject: SHAM CONTROL
subject: BIOMARKERS
subject: MICROGLIA
subject: CORD
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health

description: Abstract Background Studies regarding the impact of (neuro)inflammation and inflammatory response following repetitive, intrathecally administered antisense oligonucleotides (ASO) in 5q-associated spinal muscular atrophy (SMA) are sparse. Increased risk of hydrocephalus in untreated SMA patients and a marginal but significant increase of the serum/CSF albumin ratio (Qalb) with rare cases of communicating hydrocephalus during nusinersen treatment were reported, which confirms the unmet need of an inflammatory biomarker in SMA. The aim of this study was to investigate the (neuro)inflammatory marker chitotriosidase 1 (CHIT1) in SMA patients before and following the treatment with the ASO nusinersen. Methods In this prospective, multicenter observational study, we studied CSF CHIT1 concentrations in 58 adult and 21 pediatric patients with SMA type 1, 2 or 3 before treatment initiation in comparison to age- and sex-matched controls and investigated its dynamics during nusinersen treatment. Concurrently, motor performance and disease severity were assessed. Results CHIT1 concentrations were elevated in treatment-naïve SMA patients as compared to controls, but less pronounced than described for other neurodegenerative diseases such as amyotrophic lateral sclerosis. CHIT1 concentration did not correlate with disease severity and did not distinguish between clinical subtypes. CHIT1 concentration did show a significant increase during nusinersen treatment that was unrelated to the clinical response to nusinersen therapy. Conclusions CHIT1 elevation in treatment-naïve SMA patients indicates the involvement of (neuro)inflammation in SMA. The lacking correlation of CHIT1 concentration with disease severity argues against its use as a marker of disease progression. The observed CHIT1 increase during nusinersen treatment may indicate an immune response-like, off-target reaction. Since antisense oligonucleotides are an establishing approach in the treatment of neurodegenerative diseases, this observation needs to be further evaluated.
Sample size and item size estimation (Before registration)
Creators: name: Loevenbruck, Hélène
name: Chauvin, Alan
name: Téo Pesci
name: Huson, Nicole
name: Vanbuckhave, Claire
Publisher: name: OSF Registries
Year: 2021

description: Here you will find a comprehensive description of our procedure for estimating the required number of participants and items to have a good power. You will also find our script allowing you to reproduce our simulation.
title: OFROM: interview avec unine15a38m
Creators: name: Delafontaine, François
name: Rothenbühler, Julie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.b5ac5z6s.v2#dcd8df828f06bd1ab595d1ba8f8475df81ec6d5e
Cardiac late effects after modern 3D-conformal radiotherapy in breast cancer patients: a retrospective cohort study in Germany (ESCaRa)
Creators: name: Merzenich, Hiltrud
name: Baaken, Dan
name: Schmidt, Marcus
name: Bekes, Inga
name: Schwentner, Lukas
name: Janni, Wolfgang
name: Woeckel, Achim
name: Bartkowiak, Detlef
name: Wiegel, Thomas
name: Blettner, Maria
name: Wollschläger, Daniel
name: Schmidberger, Heinz
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Breast cancer
subject: 3D-conformal radiotherapy
subject: Cardiac mortality
subject: Cardiac morbidity
subject: Cohort study
subject: Survival
subject: HEART-DISEASE
subject: RADIATION-THERAPY
subject: ADJUVANT RADIOTHERAPY
subject: LUNG-CANCER
subject: RISK
subject: MORTALITY
subject: WOMEN
subject: CHEMOTHERAPY
subject: LATERALITY
subject: TOXICITY
subject: DDC 610 / Medicine & health

description: Abstract Purpose Radiotherapy (RT) was identified as a risk factor for long-term cardiac effects in breast cancer patients treated until the 1990s. However, modern techniques reduce radiation exposure of the heart, but some exposure remains unavoidable. In a retrospective cohort study, we investigated cardiac mortality and morbidity of breast cancer survivors treated with recent RT in Germany. Methods A total of 11,982 breast cancer patients treated between 1998 and 2008 were included. A mortality follow-up was conducted until 06/2018. In order to assess cardiac morbidity occurring after breast cancer treatment, a questionnaire was sent out in 2014 and 2019. The effect of breast cancer laterality on cardiac mortality and morbidity was investigated as a proxy for radiation exposure. We used Cox Proportional Hazards regression analysis, taking potential confounders into account. Results After a median follow-up time of 11.1 years, there was no significant association of tumor laterality with cardiac mortality in irradiated patients (hazard ratio (HR) for left-sided versus right-sided tumor 1.09; 95% confidence interval (CI) 0.85–1.41). Furthermore, tumor laterality was not identified as a significant risk factor for cardiac morbidity (HR = 1.05; 95%CI 0.88–1.25). Conclusions Even though RT for left-sided breast cancer on average incurs higher radiation dose to the heart than RT for right-sided tumors, we found no evidence that laterality is a strong risk factor for cardiac disease after contemporary RT. However, larger sample sizes, longer follow-up, detailed information on individual risk factors and heart dose are needed to assess clinically manifest late effects of current cancer therapy.
Simulated Data & Analyses
Creators: name: Barr, Dale J.
name: Henderson, Emma L
name: Simons, Daniel J.
Publisher: name: OSF Registries
Year: 2020
Subjects: Illusory truth effect
Longitudinal
Registered Report
Truth judgement

description: Simulated ratings data showing three cases: all effects null, significant main effect, and significant interaction. Download and view the html files for details. The zip file contains the simulated data needed to reproduce the results.
COVID-19 pandemic and therapy with ibuprofen or renin-angiotensin system blockers: no need for interruptions or changes in ongoing chronic treatments
Creators: name: Zolk, Oliver
name: Hafner, Susanne
name: Schmidt, Christoph Q.
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: COVID-19
subject: SARS-CoV-2
subject: Angiotensin-converting enzyme inhibitors
subject: Angiotensin receptor antagonists
subject: Non-steroidal anti-inflammatory agents
subject: CONVERTING ENZYME-2
subject: RECEPTOR BLOCKERS
subject: ACE2
subject: DDC 610 / Medicine & health

description: Abstract Scientists hypothesized that drugs such as ibuprofen or renin-angiotensin system (RAS) blockers could exacerbate the novel coronavirus disease COVID-19 by upregulating the angiotensin-converting enzyme 2 (ACE2), which serves as an entry receptor for the coronavirus SARS-CoV-2. This hypothesis was taken up by the lay press and led to concerns among doctors and patients whether the use of these drugs was still safe and justified against the background of the pandemic spread of SARS-CoV-2 with an increasing number of cases and deaths. In this article, we summarize what is known about the effect of RAS blockers or non-steroidal anti-inflammatory drugs (NSAIDs) on the course of COVID-19 disease. In the case of RAS inhibition, we also find evidence for the opposite hypothesis, namely, that RAS inhibition in COVID-19 could be protective. In view of the inconsistent and limited evidence and after weighing up the benefits and risks, we would not currently recommend discontinuing or switching an effective treatment with RAS blockers. NSAIDs should be used at the lowest effective dose for the shortest possible period. The choice of drug to treat COVID-19-associated fever or pain should be based on a benefit-risk assessment for known side effects (e.g., kidney damage, gastrointestinal ulceration).
title: Factors Associated with the Occurrence and Cessation of Relational Intrusion
Creators: name: Dutton-Greene, Leila Baldwin
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2000

description: This study investigated factors associated with the occurrence and cessation of pursuit after the termination of a romantic relationship. Participants were 384 undergraduate and graduate students at Old Dominion University and the University of Rhode Island. Questionnaires were completed by 219 female students (110 who had difficulty letting go of a relationship, 109 whose partner had difficulty letting go) and 161 male students (94 who had difficulty letting go, 67 whose partner had difficulty). Participants completed measures assessing attachment style, emotional distress at the time of break up, alternatives to the relationship, and relationship satisfaction. Those who had pursued a former partner completed questionnaires that asked about their pursuit behaviors and target's responses. Participants who had been pursued by a former partner completed questionnaires about the types of behaviors the pursuer engaged in and how they responded to the pursuit. Support was not found for the hypotheses that participants with a preoccupied attachment style would report more relational pursuit than those with secure, fearful, or dismissing styles and those with a secure attachment style would report less pursuit than those with fearful, dismissing, and preoccupied styles. Attachment anxiety, however, was predictive of relational pursuit as was emotional distress. For pursuers, greater levels of distress over the break up and fewer alternatives to the relationship were associated with a higher degree of relational intrusion. Gender differences in experiences and responses, effectiveness of response strategies for ending the pursuit, and specific events or factors that lcd to cessation of pursuit were investigated.
Right ventricular free wall longitudinal strain and strain rate quantification with cardiovascular magnetic resonance based tissue tracking
Creators: name: Qu, Yang-Yang
name: Li, Hao
name: Rottbauer, Wolfgang
name: Ma, Gen-Shan
name: Buckert, Dominik
name: Rasche, Volker
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Cardiovascular magnetic resonance
subject: Tissue tracking
subject: Right ventricle
subject: Strain
subject: Strain rate
subject: DDC 610 / Medicine & health

description: Abstract Cardiovascular magnetic resonance based tissue tracking (CMR-TT) was reported to provide detailed insight into left ventricular mechanical features. However, inadequate knowledge of the right ventricle (RV) mechanical deformation has been acquired by this advanced technique so far. It was the aim of this study to establish reference values of RV free wall (RVFW) global, regional and segmental longitudinal peak strain and strain rate (LS and LSR), and to investigate the gender- and age-related difference as well as the base-to-apex gradient of RVFW-LS and LSR with CMR-TT. 150 healthy volunteers (75 males/females) were retrospectively and continuously recruited and subdivided into three age groups (G20–40, G41–60 and G61–80). RVFW global, regional (basal, middle-cavity and apical) and segmental LS (GLS, RLS, SLS) along with systolic and diastolic LSR were generated by post-hoc CMR-TT analysis of standard steady-state free precession long-axis four-chamber view cine images acquired at 1.5T field strength. The reference value of myocardial RVFW-GLS was − 24.9 ± 5.2%. We found that females showed more negative GLS than males except in the youngest group, and no age-related difference of GLS was observed in both gender groups. RLS and SLS presented with the same age-related tendency as GLS. The basal and middle-cavity LS were similar between each other and significantly larger than apical LS. RVFW-GLSR resulted as − 1.73 ± 0.58 s−1 and 1.69 ± 0.65 s−1 during systolic and diastolic phases, respectively. The diastolic GLSR of males tended to decline with the ageing and was significantly lower than that of females in G61–80 group. Regional and segmental LSR showed significant gender-related differences in certain basal and apical region/segments without any age-related effects. CMR-TT overcomes the difficulty in measuring RV global and segmental deformation. The establishment of the vendor-, gender- and segment-specific reference values of RVFW-LS and LSR is essential for the rapid and efficient utilization of CMR-TT modality in the clinical routine.
title: Belastungen und Beanspruchung bei Sportlehramtsstudierenden: eine qualitative Studie
titleType: Other
Creators: name: Bastemeyer, Carolin
name: Bartsch, Fabienne
name: von Haaren-Mack, Birte
Publisher: name: Deutsche Sporthochschule Köln
Year: 2021

description: Typische Belastungen, die bei Studierenden mit einer Beanspruchung einhergehen sind Belastungen, die sich aufgrund der Charakteristik des Studiums oder des Alltags neben dem Studium ergeben. Das Sportlehramtsstudium ist im Vergleich zu anderen Fächergruppen durch spezielle Rahmenbedingungen gekennzeichnet. Welche Belastungen Sportlehramtsstudierende wahrnehmen und welche Beanspruchungsfolgen sich durch Belastungen ergeben, wurde bisher noch nicht untersucht. Daher ist das Ziel dieser qualitativen Interviewstudie, Belastungen und Beanspruchungsfolgen bei Sportlehramtsstudierenden zu analysieren.
Elf Sportlehramtsstudierende wurden mittels halbstrukturierter Interviews zu Belastungen und Beanspruchungsfolgen während ihrer Studienzeit befragt. Die Interviewtranskripte wurden auf Basis der strukturierenden Inhaltsanalyse ausgewertet.
Die Ergebnisse zeigen, dass Sportlehramtsstudierende Belastungen wie zum Beispiel hochschulbedingte Belastungen aufgrund der Prüfungsphase wahrnehmen. Darüber hinaus werden zusätzlich sportpraktisch bedingte Belastungen, wie z.B. Verletzungen, genannt. Als damit einhergehende Beanspruchungsfolgen werden Schlafprobleme oder Konzentrationsschwierigkeiten angegeben.
Auf Grundlage der hier identifizierten Belastungen und Beanspruchungsfolgen können stresspräventive Maßnahmen für die erste Bildungsphase von angehenden Sportlehrkräften entwickelt werden. Diese beinhalten unter anderem eine Sensibilisierung für körperliche Belastungen und das Erkennen von Beanspruchungsfolgen.
title: OFROM: interview avec unine15a37d
Creators: name: Delafontaine, François
name: Legrand, Camille
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.2ba87761.v2#6d7975b89a8a2eee44e4219f3f835ef6bbf69273
Determinants of job separation and occupational mobility in Australia
Creators: name: Shah, Chandra
Publisher: name: Monash University
Year: 2016
Subjects: Uncategorized

description: In the year to February 2002, one in every five of the 9.8 million people who worked in Australia experienced at least one job separation. This paper looks at the determinants of job separation within a stayer/mover framework using individual-level data for Australia. Conditional on job separation the paper also investigates the determinants of job-to-job turnover (differentiated by occupation) and job-to-joblessness turnover (unemployment and exit from the labour force). The results show the importance of the normal demographic variables (age, gender, immigrant status and place of residence) but also qualifications and other labour market variables (hours of work, reason for job separation) for explaining turnover behaviour.
Reanalysis of Nadarevic & Erdfelder (2014)
Creators: name: Barr, Dale J.
name: Henderson, Emma L
Publisher: name: OSF Registries
Year: 2020
Subjects: Illusory truth effect
Longitudinal
Registered Report
Truth judgement

description: Ordinal logit re-analysis of Nadarevic and Erdfelder (2014) Experiment 1. For details, please download and view 01_02_preprocessing.html and 03_ordinal_clmm.html in your browser.
Role of lower-level qualifications in Australia's vocational education and training system
Creators: name: Shah, Chandra
name: Long, Michael
name: Perkins, Kate
name: Brown, Justin
Publisher: name: Monash University
Year: 2016
Subjects: Uncategorized

description: This report considers the role of lower-level qualifications (Certificate I and II) in Australia's national vocational education and training system. It was prepared for the former Australian Workforce and Productivity Agency by the Centre for the Economics of Education and Training (CEET), Faculty of Education, Monash University in collaboration with the Australian Council for Educational Research (ACER). The report includes a review of the research literature, analyses of relevant data and policy documents and accounts of the views of industry skill councils (ISC) and state training authorities (STA) gathered by questionnaire and consultations for the purposes of this report.
Quantifying progression in primary progressive aphasia with structural neuroimaging
Creators: name: Lombardi, Jolina
name: Mayer, Benjamin
name: Semler, Elisa
name: Anderl‐Straub, Sarah
name: Uttner, Ingo
name: Kassubek, Jan
name: Diehl‐Schmid, Janine
name: Danek, Adrian
name: Levin, Johannes
name: Fassbender, Klaus
name: Fliessbach, Klaus
name: Schneider, Anja
name: Huppertz, Hans‐Jürgen
name: Jahn, Holger
name: Volk, Alexander
name: Kornhuber, Johannes
name: Landwehrmeyer, Bernhard
name: Lauer, Martin
name: Prudlo, Johannes
name: Wiltfang, Jens
name: Schroeter, Matthias L.
name: Ludolph, Albert
name: Otto, Markus
name: Consortium, The FTLD
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: atlas‐based volumetry
subject: longitudinal magnetic resonance imaging
subject: primary progressive aphasia
subject: sample size calculation
subject: DDC 610 / Medicine & health
subject: Frontotemporal dementia
subject: Neuroimaging
subject: Magnetic resonance imaging
subject: Disease progression
subject: Frontotemporale Demenz
subject: Aphasie
subject: Kernspintomografie

description: Abstract Introduction The term primary progressive aphasia (PPA) sums up the non‐fluent (nfv), the semantic (sv), and the logopenic (lv) variant. Up to now, there is only limited data available concerning magnetic resonance imaging volumetry to monitor disease progression. Methods Structural brain imaging and an extensive assessment were applied at baseline and up to 4‐year(s) follow‐up in 269 participants. With automated atlas‐based volumetry 56 brain regions were assessed. Atrophy progression served to calculate sample sizes for therapeutic trials. Results At baseline highest atrophy appeared in parts of the left frontal lobe for nfvPPA (–17%) and of the left temporal lobe for svPPA (–34%) and lvPPA (–24%). Severest progression within 1‐year follow‐up occurred in the basal ganglia in nfvPPA (–7%), in the hippocampus/amygdala in svPPA (–9%), and in (medial) temporal regions in lvPPA (–6%). Conclusion PPA presents as a left‐dominant, mostly gray matter sensitive disease with considerable atrophy at baseline that proceeds variant‐specific.
The impact of activating an empathic focus during COVID19 on healthcare workers motivation for hand hygiene compliance in moments serving the protection of others : a randomized controlled trial study
Creators: name: Sassenrath, Claudia
name: Diefenbacher, Svenne
name: Kolbe, Viktoria
name: Niesalla, Heide
name: Keller, Johannes
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Hand hygiene compliance
subject: Empathic focus
subject: COVID-19 pandemic
subject: DDC 610 / Medicine & health
subject: COVID-19 Pandemic, 2020-
subject: Hygiene

description: Aim The “Five moments of hand hygiene” (World Health Organization 2009) can be classified into moments of hand hygiene before and after patient care. Based on research indicating that hand hygiene compliance differs with regard to moments before and after patient care, this research evaluates the effectiveness of an empathy-based intervention in motivating hand hygiene compliance with regard to moments before patient care which protect vulnerable individuals from contamination and infection. Subjects and method An online experiment involving 68 healthcare professionals working at a German hospital during the first wave of the COVID-19 pandemic investigates whether instructing healthcare professionals to consider consequences for others (vs for themselves) if they contracted SARS-CoV-2 promotes hand hygiene compliance referring to moments before (vs after) patient care. Results In the condition in which healthcare professionals considered consequences for others if they contracted SARS-CoV-2 (other-focus condition), ratings of importance increased (M = 3.49, SD = 1.30) compared to the condition in which healthcare professionals considered consequences for themselves (M = 2.68, SD = 1.24), F(1,66) = 6.87, p = .011, partη2 = .09. Participants in the other-focus condition reported more intentions to comply with “before moments” in the future (M = 3.34, SD = 1.14) compared to participants in the self-focus condition (M = 2.77, SD = 0.80), F(1,66) = 6.15, p = .016, partη2 = .09. Conclusion Results indicate that activating an empathic focus in the context of the current pandemic promotes perceived importance and motivation of healthcare professionals to comply with moments aiming at protecting vulnerable others.
The Discovery of the Atomic World and the Constituents of Matter.pdf
Creators: name: Forrester, Rochelle
Publisher: name: figshare
Year: 2016
Subjects: History

description:
 The change from the traditional Western and Chinese view of the elements involving materials such as water, air, earth, wood, metal and fire, to the chemical elements making up the periodic table, to atoms, to particles such as protons, neutrons and electrons, and then to quarks was inevitable. The order of discovery of these ideas of the ultimate constituents of matter was necessary, in that they could not have been discovered in any other order. This was because nature has a particular structure and we have a particular place in nature. The traditional view of the elements could be obtained by naked eye observation, and the view of nature as being made up of the chemical elements in the periodic table was next discovered, as it involved the decomposition of traditional elements, such as air and water. This led to the idea there was a separate atom for each element which explained the differences between the elements. The sub atomic particles were discovered in a necessary order with the outer particles like the electron being discovered earlier, and inner particles such as quarks being discovered later. The order of discovery of particles is also affected by the properties of the particles. The charges of particles, their mass and ability to survive outside the particles they make up, and other properties will make a particle harder or easier to discover. The order of discover is inevitable and set by the structure of the universe. The structure of the universe includes the structure of the atom, and of the particles making up the atom, and the properties of the atom, and of the particles making up the atom.
We're not doctors and nurses: the teacher's role in the management of anaphylaxis in primary school settings
Creators: name: Eastwood, Kate
name: Cutter-Mackenzie, Amy
Publisher: name: Monash University
Year: 2016
Subjects: subject: 130102 Early Childhood Education (excl. Maori)
subject: FOS: Educational sciences
subject: 130313 Teacher Education and Professional Development of Educators
subject: 130202 Curriculum and Pedagogy Theory and Development

description: Worldwide the prevalence of severe and life threatening allergies is rising. In 2007 35% of Victorian schools had students at-risk for anaphylaxis (Office of the Premier), and three children have allegedly died from anaphylaxis in Australian school and early childhood education settings during the last six years alone. Teaching personnel are increasingly responsible for the safety of severely allergic children, yet there is a dearth of research examining anaphylaxis management in Australian educational and child-care facilities. This study examines the teacher's role in anaphylaxis management through in depth interviews with 12 Victorian primary school teachers. The resulting data indicate that teachers' roles in anaphylaxis management were complex, multifaceted, and emotionally demanding. Stress and anxiety were strongly associated with the onus to prevent a reaction, and to provide medical care in the event of an emergency. Participants considered such responsibilities beyond the reasonable parameters of teacher duties yet an increasingly common expectation in a teaching climate characterised by work intensification. Stress and coping was impacted primarily by a number of local sociocultural factors such as the attitude of parents and colleagues. Factors identified in previous literature were also significant, namely, clear policy and procedures; and practical considerations such as teacher education and safety measures.
International Research in Early Childhood Education, vol. 1, no. 1, p. 34-49
Researching an everyday teacher in 1940s New Zealand: new liaisons - new stories
Creators: name: Bethell, Kerry
name: Sewell, Alison
Publisher: name: Monash University
Year: 2016
Subjects: subject: 130102 Early Childhood Education (excl. Maori)
subject: FOS: Educational sciences
subject: 130313 Teacher Education and Professional Development of Educators
subject: 130202 Curriculum and Pedagogy Theory and Development

description: The growth of interest in historical research into the commonplace provides opportunities to explore the different means through which we can understand the everyday world of teachers. Unlike the 'well-known' in education past, where significant traces of their lives remain in archives and official records, little such evidence exists of the lives and work of 'ordinary' teachers. Traditional biographical approaches are of limited use. Alternative approaches are needed to find teachers' stories of their everyday work. This paper explores our dynamic research process to piece together a partial story of the work of Miss Audrey Newton, a New Zealand kindergarten teacher in the 1940s. Fragments of evidence including photographs and other personal sources provide previously unknown evidence of Audrey's life over this time and glimpses into her experience of teaching. Also significant was our collaborative relationship that evolved bringing together historical and dialogic methodologies. These newly found sources of data, and our collaborative analysis of them, reveal a fuller and more complex picture of Audrey and of the context in which she taught than first considered.
International Research in Early Childhood Education, vol. 1, no. 2, p. 13-28
Observing children when using computers with a focus on their self-esteem
Creators: name: Hatzigianni, Maria
name: Margetts, Kay
Publisher: name: Monash University
Year: 2016
Subjects: subject: 130102 Early Childhood Education (excl. Maori)
subject: FOS: Educational sciences
subject: 130313 Teacher Education and Professional Development of Educators
subject: 130202 Curriculum and Pedagogy Theory and Development

description: Children are born into a rich technological environment and by the time they attend preschool they already have accumulated a wide variety of technological experiences, skills and knowledge. This paper reports on part of a project undertaken in Melbourne, Australia, which had as a primary aim to explore the existence or not of a relationship between computer use and young (4-6 year old) children's self-esteem. Observing children's interactions with computers was one of the data collection methods utilised in this study. The twofold analysis of the observations, the findings related to self-esteem and children's interactions with computers are the focus of this paper and are considered to be interesting and useful for the early childhood educators.
International Research in Early Childhood Education, vol. 1, no. 2, p. 69-86