cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Multistate Computational Protein Design: Theories, Methods, and Applications
Creators: name: Davey, James A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: computational protein design
multistate design
protein engineering
molecular modeling
substrate multispecificity
protein stability
protein dynamics

description: Traditional computational protein design (CPD) calculations model sequence perturbations and evaluate their stabilities using a single fixed protein backbone template in an approach referred to as single‐state design (SSD). However, certain design objectives require the explicit consideration of multiple conformational states. Cases where a multistate framework may be advantageous over the single‐state approach include the computer aided discovery of new enzyme substrates, the prediction of protein stabilities, and the design of protein dynamics. These design objectives can be tackled using multistate design (MSD). However, it is often the case that a design objective requires the consideration of a protein state having no available structure information. For such circumstances the multistate framework cannot be applied. In this thesis I present the development of two template and ensemble preparation methodologies and their application to three projects. The purpose of which is to demonstrate the necessary ensemble modeling strategies to overcome limitations in available structure information. Particular emphasis is placed on the ability to recapitulate experimental data to guide modelling of the design space. Specifically, the use of MSD allowed for the accurate prediction of a methyltransferase recognition motif and new substrates, the prediction of mutant sequence stabilities with quantitative accuracy, and the design of dynamics into the rigid Gβ1 scaffold producing a set of dynamic variants whose tryptophan residue exchanges between two conformations on the millisecond timescale. Implementation of both the ensemble, coordinate perturbation followed by energy minimization (PertMin), and template, rotamer optimization followed by energy minimization (ROM), generation protocols developed here allow for exploration and manipulation of the structure space enabling the success of these applications.
The Design and Implementation of Genomics Tools for Enhanced Detection and Characterization of Verotoxigenic Escherichia coli Implicated in Foodborne Illness
Creators: name: Knowles, Michael
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017

description: Motivation Control strains of bacterial pathogens are commonly processed in parallel with test samples in food microbiology laboratories assuring the satisfactory performance of materials used in the analytical procedure. Before positive findings can be reported for risk management purposes, analysts must have a means of verifying that pathogenic bacteria recovered from test samples are not due to inadvertent contamination with the control strain. In addition to detection of laboratory control strains, genomic antimicro- bial resistance (AMR) prediction tools may be very useful in supporting food-borne ill- ness outbreak investigations through their application in the analysis of bacterial genomes from causative strains. The AMR marker profile from an outbreak strain of interest could be compared with related bacteria to determine the presence of unique resistance mark- ers enabling customization of selective enrichment media facilitating their recovery from samples during food safety investigations. Food safety investigations focusing on both control strain and priority bacterial pathogen detection, characterization and selective recovery would benefit from a practical means of differentiating between phylogenetically similar isolates. Results We describe the implementation of a novel algorithm for the identification of DNA signature sequences enabling differentiation of phenotypically related bacterial strains within the same species. This tool, which we have named SigSeekr, was applied in the analysis of whole genome sequence data from select Escherchia coli and Salmonella enterica strains, enabled the development of primers for their specific detection and differ- entiation from closely related bacteria using polymerase chain reaction (PCR) techniques. We applied this tool enabling the identification of a common positive control strain using a simple PCR procedure. We combined SigSeekr with selective recovery (using AMR) and identification tools for the efficient detection of verotoxin-producing Escherichia coli (VTEC) outbreak strains within the timeframe of an active investigation. Conclusion We used SigSeekr in a simple PCR procedure to differentiate three E. coli and one Salmonella enterica between phylogenetically strains including control strains. We also discuss the relative merits of different AMR marker prediction tools employing bioinformatics alignment algorithms along with comprehensive AMR gene databases such as CARD (e.g., Antimicrobial Resistance Marker Identifier [ARMI]), or publicly avail- able tools which use more limited acquired AMR gene databases (e.g., ResFinder), and describe how such tools can be utilized to good effect in a typical outbreak investigation.
Réconciliation locale et construction de la paix : relation plausible? Le cas du département d'Angaraes, Huancavelica, Pérou
Creators: name: St-Laurent, Sophie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Peacebuilding
Réconciliation
Pérou
résolution de conflit
micro-processus
Paix

description: Les approches internationales en matière de paix et de réconciliation ont beaucoup évolué depuis le début des années 2000, en tentant d’inclure notamment de plus en plus le niveau local dans le but de favoriser l’appropriation des processus de paix et de réconciliation suite à un conflit interne. Or, ces nouvelles approches théoriques proposent des pistes de solutions sans même avoir consulté les populations locales afin d’identifier leurs besoins en matière de paix et de réconciliation, et sans avoir développé une meilleure compréhension des relations et des interactions locales en période post-conflit. Cette recherche se base sur une étude ethnologique réalisée dans la municipalité de Julcamarca, au Pérou, afin de déterminer quels sont les processus nécessaires dans une communauté ayant été affectée par un conflit interne – entre 1980 et 2000 – pour retrouver la paix et atteindre la réconciliation. Les éléments découverts lors de la recherche, basés sur les définitions locales de paix et de réconciliation plutôt que sur les concepts occidentaux plus souvent utilisés, permettent par la suite une analyse des résultats locaux en matière de paix et de réconciliation, comparativement aux débats théoriques de la 4e génération de pensées en construction de la paix en relations internationales.
The Contribution of Reinfections to Chlamydia Resurgence, Sexual Networks, and Spatial Clustering in Brant County, Ontario
Creators: name: Santos, Jenny Pereira
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: STIs
chlamydia
sexually transmitted infections
spatial analysis
reinfection
core group theory

description: Recent findings by Public Health Ontario (PHO) state that there were approximately 36, 346 confirmed cases of chlamydia in Ontario as of 2011. This represents an incidence rate that increased by 54% since 2006 rising from 177 to 272 per 100,000 in 2011. National rates only increased by 38% (210 to 290 per 100,000), meaning that Brant County rates surpassed both, increasing by over 100% (150 to 395 per 100,000). The main objective of this series of manuscripts is to develop a clear profile of re-infected individuals in comparison to non-repeaters, while considering co-infections wit gonorrhea. The secondary objective was to determine the sexual network as well as spatial distribution patterns of cases in Brant County. The study period is from January 1st, 2006 until December 31st, 2015, Data were extracted from the integrated public health information system (iPHIS). Basic descriptive statistics will be performed followed by a Cox-regression analysis in order to compare individuals who are repeaters with those who are not repeaters. Within the study period, there were 2,829 cases of chlamydia and 328 were reinfections. We identified twelve hotspots with high chlamydia infection rates of which, 58 per cent occurred within the previously identified core group, in the urban core of Brant County.
Spirituality and Religion as Coping Mechanisms: Families Raising Children with Developmental Disabilities
Creators: name: Shackell, Erin M.A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Disability
Coping
Sprituality
Religion

description: The process of rearing a child with a developmental disability is arguably difficult for many families, yet there appears to be some families and parents who cope more easily with their child’s disability. Two additional factors, which have been identified as coping resources and have become rather popular in the realm of resiliency research, are spirituality and religiosity. The study sought to address the hypothesis that aspects of spiritual well-being as measured by the Holistic Spirituality Model (Rovers & Kocum, 2010) would predict better familial coping beyond the contribution of other demographic and psychosocial factors. Additionally this study was addressing the hypothesis that other previously significant psychosocial variables would become less predictive of familial ability to cope with the addition of spirituality and religiosity to the model. Lastly it was predicted that individual subscales of the Holistic Spirituality Model would correlate with better scores on the Questionnaire on Resources and Stress which measured the family’s ability to cope with raising a child with a developmental disability. This study is a replication of a previous study conducted by Jones and Passey (2004), with the addition of the Holistic Spirituality Model developed by Rovers and Kocum (2010). A hierarchical regression analysis was conducted, blocking variables by questionnaire while controlling for specific demographic variables. Results suggest no support for the first two hypotheses. A positive correlation was found between the existential well-being subscale of the Holistic Spirituality Model and the Questionnaire on Resources and Stress which measured familial coping while raising a child with a developmental disability.
From the Conflict of Domestic Violence to the Pursuit of Intra-psychic Reconciliation: A Blended Theory (Grounded, Heuristic and Structures of Blessing) Probe of Spirituality and Religious Based Coping Strategies; in the Context of Domestic Violence as Experienced by First Nations Women in Sioux Lookout Zone
Creators: name: Kirlew, Marsha-Yolaine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: First Nations Women
Domestic Violence
Spirituality
Religious Beliefs
Coping Strategies
Intra-psychic Reconciliation
Sioux Lookout Zone

description: This research sought to chart how knowledge about spirituality and religious based teachings influenced some women from the Sioux Lookout, north western Ontario region. It focused amongst the life-world experiences of four First Nation’s female domestic violence (DV) survivors who are in the process of pursuing intra-psyche (self) reconciliation. Listening to and examining their stories revealed the inter-sectionality of DV and Spirituality or Religious beliefs, and how they have worked to shape their Identity. In the process, new insights arouse on the various paths that may exist on the road towards personal reconciliation. New knowledge can also emerge alongside the data sought from unfamiliar places. Engaging in Grounded Theory (GT) research paved the way to combine an emergent Heuristic, Structure of Blessing approach: this enabled the researcher to personally examine and reflect on her own legacy as a survivor of childhood trauma. The outcome of using a theoretical relay approach to theory development is that research on spirituality can create the context to chart emergent, creative knowledge-making as a spiritual journey. The research uses an integrative Peace and Conflict Impact Assessment (PCIA) mapping exercise in combination with Redekop's (2002a, 2012) notion that reconciliation creates a positive context that benefits from Structures of Blessing. This revealed that some Aboriginal women use their spirituality (informed by teachings) and or religious beliefs as guides.
Stellar winds from B supergiant stars: Exploring the delta-slow hydrodynamic solution
Creators: name: Venero, Roberto Oscar José
Publisher: name: Zenodo
Year: 2024

description: The B-type supergiant stars form a heterogeneous group of objects, within which various types of peculiar stars coexist in brief and distinctly different evolutionary stages. Ordering the evolutionary sequences for these diverse stellar groups and assigning each star its respective phase poses a challenge. Nonetheless, the strong stellar winds of these stars produce observable spectral features that could serve as valuable diagnostic tools in addressing this question. In order to utilize these characteristics, it is necessary to know the structure of the wind in detail.The fundamental hydrodynamic equations governing radiation-driven winds (m-CAK theory) predict three distinct solutions for rotating stellar winds. These solutions include the ‘fast’ solution (or classical), the ‘Omega-slow’ solution (applicable to rapidly rotating stars), and the ‘delta-slow’ solution (pertaining to winds with ionization changes). These solutions are primarily distinguished by the terminal speed achieved by the wind, with the ‘fast’ wind regime exhibiting the highest values for this parameter.Excluding the ‘Omega-slow’ solutions due to the absence of fast rotation in B supergiants, the ‘fast’ and ‘delta-slow’ solutions are distributed in distinct domains within the classical parameter space of the radiation force (k, alpha, and delta). In this presentation, I will illustrate the distribution of these domains and, more specifically, asses the ability of the delta-slow solution in predicting the fundamental spectral characteristics observed in B supergiants.
A Mixed Methods Study of the Factors that Enhance and Challenge Food Security, Fruit and Vegetable Access and Consumption, and the Uptake and Management of the Ottawa Good Food Box
Creators: name: Lecompte, Emily M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Food security
fruit and vegetable consumption
Community food programs
fruits and vegetables
Mixed methods
Good Food Box Program
Community needs assessment

description: Individuals who are disadvantaged by low-income and/ or minority status face a number of barriers to experiencing optimal health and eating well. Twenty Aboriginal and 29 non-Aboriginal participants (N = 49) from Ottawa, Canada took part in a cross-sectional, mixed methods study and completed one questionnaire and single in-depth interview that verified: 1) food security status and household eating habits, 2) fruit and vegetable purchase and consumption, and 3) knowledge about or participation in the Good Food Box [GFB] Program. Ottawa GFB staff (n = 5), site coordinators (n = 6) and steering committee members (n = 3) took part in separate discussion groups to identify challenges and strengths related to program coordination, management and delivery. Within an ecological framework, qualitative data is discussed using a social phenomenological and thematic approach. Using χ2 analyses, results suggest a medium effect size and association between food security status and Aboriginal identity (χ2(1) = 8.04, p < 0.01; φ = 0.4) and satisfaction with how stores meet household food needs and gender (χ2(1) = 5.86, p < 0.05; φ = 0.36). A relationship between participation in the GFB Program and food security status (χ2(1) = 11.13, p < 0.01; φ = 0.48) is also shown where estimates suggest that GFB customers are 9.9 times more likely to be food secure compared to non-affiliates. ANOVA results and post-hoc tests demonstrate a significant mean difference in frequency of fruit consumption between GFB customers and non-program users (F(2, 46) = 11.29, p = 0.00) where 29.6% of the variance (ω2 = 0.296) is explained by program participation. Results-based and community-driven recommendations to improve access to healthy food, food security and the GFB Program are discussed as shared responsibilities between different levels of government across sectors and the community since these are public and social health issues, determinants of health and economic concerns. Implications of findings are also discussed.
Pseudamnicola Paulucci 1878
Creators: name: Glöer, Peter
name: Stefanov, Tihomir
name: Georgiev, Dilian
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Hydrobiidae
Pseudamnicola

description: Genus Pseudamnicola Paulucci, 1878
 Type species: Bithynia lucensis Issel, 1866
description: Published as part of Glöer, Peter, Stefanov, Tihomir & Georgiev, Dilian, 2018, A new Pseudamnicola (Gastropoda: Hydrobiidae) from the Island of Limnos (Greece), pp. 159-162 in Ecologica Montenegrina 19 on page 160, DOI: 10.37828/em.2018.19.16, http://zenodo.org/record/13360054
Religion in Education and Conflict: Lebanon and Northern Ireland Compared
Creators: name: Cervan Gil, Daniel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Religion
Education
Lebanon
Peacebuilding
Reconciliation
Conflict Transformation
Peace Education
Religious Education
Northern Ireland
Socialization
Consociational Democracy
Confessional Schools

description: The Lebanese educational system has been blamed for being a contributing factor to political and social polarization. Assuming that religion in Lebanese private and public schools can enhance integration and cohesion of the Lebanese society or increase conflict through the propagation of fundamentalism, this study compares and contrasts the role of religion in the Lebanese and the Northern Irish educational system. While making the comparison, the advancements made in Northern Ireland are given as examples and by using these examples evaluations are carried out in the framework of conflict transformation, psycho-social theory and peace education approaches. Three major aspects of the Lebanese educational system that arguably need to be reformed include the existence of a majority of private confessional schools; the irresponsible use of education by religious communities in confessional schools to promote sectarianism; and the approach to religious education in both confessional and public schools.
Valence electronic structure of 2,6-stelladione: experimental and computational studies
Creators: name: Appelbe, Bill
name: Brunger, Michael
name: Campbell, Lawrence
name: Gleiter, Rolf
name: Loeb, P.
name: Nixon, Kate L.
name: Wang, Feng
name: Winkler, Dave A.
Publisher: name: Swinburne
Year: 2024

description: Abstract not available.
Development of Field Scenario Ray Tracing Software for the Analysis of Bifacial Photovoltaic Solar Panel Performance
Creators: name: Li, Chu Tu
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Bifacial solar cell
Bifacial solar panel
Perez sky diffuse model
Gueymard directional reflection
solar panel simulation
Solar panel shading

description: This thesis is based on a project "Bifacial Photovoltaic Energy Production Analysis" to build a detailed simulation model system accurately simulate bifacial panel performance under real field radiation conditions and deployment configuration, and to predict its corresponding energy yield. To the author’s up-to-date knowledge, the model system is unpreceded among same type simulation software in complexity, details in consideration, ranges of deployment and parameters. The model system can also be used as a platform for more components and variables to be added on, such as adding on more rows of panel arrays to simulate bifacial solar farm scenario; and adding spectral information for more accurate analysis. The system components’ sub-models were carefully chosen based on a broad literature review in related aspects; especially in sky diffuse radiance, ground reflection, and bifacial solar cells. Built in MATLAB© based on mathematical expressions from above said models, the system consists of 5 bifacial panels and their racking as shading objects and the central panel performance is under investigation and has taken consideration of all possible panel azimuth and elevation combinations. Model simplification and resolution are carefully considered so to achieve a good balance in complexity, computation load and output accuracy. Output reliability is confirmed with other people’s work. Furthermore, the model has been fully checked and peer tested. Outputs under different parameter settings are analysed and discussed. Conclusions and recommended future work are provided at the end of the thesis.
Le dirictionnaire¹ de la Banque Nationale : être dans tous ses états d'esprit
Creators: name: Viau-Petit, Julien
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: actionnaires
dirigeants
ventriloquie
postmodernisme

description: Plusieurs actionnaires minoritaires veulent prendre une place plus importante dans le processus de décision des entreprises dans lesquelles ils investissent. Ils participent aux assemblées annuelles, soumettent des propositions. Mais les dirigeants prennent-ils en compte les considérations de ces actionnaires? Pour le savoir, l’étude utilise les approches déconstructives de la ventriloquie et de la narration postmoderne pour comparer ce qui anime les différents acteurs à l’aide d’une analyse de vidéos des assemblées de la Banque Nationale du Canada de 2014, de 2015 et de 2016. L’image du théâtre est employée pour illustrer à la fois la construction de la thèse et de l’organisation : avec la déconstruction, on met en pièces.
Ecological Praxis as Discipleship: Developing a Model of Praxis from Sallie McFague's Theological Call for Consumption Reduction
Creators: name: Hetherington, Jessica Claire Fraser
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Sallie McFague
Ecotheology
Ecological Praxis
Discipleship

description: This thesis is a constructive response to the challenge of changing human behaviour in the face of the ecological crisis. I examine the writings of theologian Sallie McFague who argues that in the middle-class North American context, a Christian ecological praxis of consumption reduction is theologically necessary. Such praxis, for McFague, is understood as a form of Christian discipleship. However, while she calls for this praxis, McFague does not develop it. The methodology behind McFague’s call for ecological praxis emerges from her earlier scholarship. I excavate McFague’s comprehension of action located in her parabolic and metaphorical theologies and construct it into a coherent model of praxis that undergirds McFague’s later call for ecological praxis. McFague focuses on the function of metaphor in the relationship among belief, language and action in people’s lives. The model of praxis constitutes a rich, complex framework for interpreting an ecological praxis of consumption reduction. However, the model as it stands does not factor in insights made in ecotheology. These insights illustrate the unique demands and opportunities the ecological crisis affords human beings in terms of their behaviour and relationships with God. Thus, I develop the model of praxis using key contributions from McFague’s own ecotheology. Finally, I turn to the question of how to elicit ecological praxis in people’s lives. I begin a heuristic inquiry into the possibilities of ecological literacy as a tool for engaging in the praxis McFague advocates. The primary finding in this thesis is that the methodology behind McFague’s call for an ecological praxis of consumption reduction is based upon an early and enduring concern for Christian discipleship, understood as Christian belief lived out in the world. For McFague, the foundation of ecological praxis is found in the function of metaphor in the relationship among belief, language and action. This foundation is complex and highly nuanced. Through my own construction and a further development of a model of praxis based upon McFague’s ideas, I am able to present from McFague’s theological scholarship a cogent and indispensable framework for understanding human action in light of belief and the ecological crisis.
The Structural Basis for Lipid-Dependent Uncoupling of the Nicotinic Acetylcholine Receptor
Creators: name: Sun, Jiayin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Structure
Lipid-protein interactions
Mechanism
Nicotinic acetylcholine receptor
Uncoupling
ELIC
Pentameric ligand-gated ion channels

description: In lipid membranes lacking activating lipids, the nicotinic acetylcholine receptor adopts an uncoupled conformation that binds ligand, but does not transition into an open conformation. Understanding the mechanisms of lipid-dependent uncoupling is essential to understanding lipid-nAChR interactions, which may be implicated in pathological conditions such as nicotine addition. Here, I tested two structural features of a proposed uncoupling method to elucidate the mechanism of lipid-dependent uncoupling. First, infrared measurements and electrophysiological characterization performed in prokaryotic homologues indicate that lipid sensitivity is largely controlled by the most peripheral α-helix in the transmembrane domain, M4. My data show that tighter association of M4 with the adjacent M1 and M3 transmembrane α-helices decreases a receptor’s propensity to adopt a lipid-dependent uncoupled conformation. Second, I indirectly tested the hypothesis that uncoupling results from a conformational change at the extracellular/transmembrane domain interface that leads to an increased separation between the two domains and ultimately to a constriction of the channel pore. Finally, biophysical studies presented in this dissertation shed light on the complex binding of a number of non-competitive channel blockers to the nicotinic acetylcholine receptor channel pore in both the resting and desensitized states. The data provide further insight into the structural rearrangements that occur upon uncoupling of ligand binding and gating in the nicotinic acetylcholine receptor.
The Untold Stories of Women Soccer Referees
Creators: name: Reid, Kamiel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Women
Soccer
Referee
Foucault
Discourse
Subject
Ability
Outsider

description: In Canada, women’s soccer has continuously grown and developed, however women continue to be under represented in non-playing roles – particularly as referees (Canadian Heritage, 2013; Canadian Soccer Association, 2013a; Ontario Soccer Association, 2012). Of the 20,507 soccer referees in Canada, only 24% are women (Canadian Soccer Association, 2013a). Moreover, 54% of Canadian soccer referees are registered in Ontario (Ontario Soccer Association, 2012), of which only 9.5% are women (Ontario Soccer Association, 2013). This study explores the experiences of women who continue to referee despite their under-representation within the refereeing domain, in an effort to identify the benefits and challenges of being a woman soccer referee in Ontario. I employed a feminist lens to guide the development and design of the research agenda, alongside Michel Foucault’s concept of the subject. The results of this exploration uncovered that the woman soccer referee subject comes to recognize and understand herself and her role as a referee through the discourse of ability and the discourse of the outsider. These discourses emerged from the ways in which the subject constructed becoming a referee, being a referee (benefits and challenges), continuing to referee, and being a woman soccer referee. Resultantly, the woman soccer referee is primarily motivated to continue to referee by her competence to perform according to the ideals and practices of “the referee” that she learns through both education and experience. However, as woman she is an outsider within the soccer community and comes to internalize her subordination and normalize sexism within the refereeing domain and soccer community at large in order to be accepted and respected within her position as “the referee”. Using the results of analysis I also make recommendations for increasing the number of women that choose to continue, as well as boost the notoriety of women soccer referees within the refereeing domain.
Investigation of VARTM Resin Flow Through 3D Near Net-Shape Aerospace Preforms
Creators: name: Proulx, Francois
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Composite
Manufacturing

description: The manufacturing of complex aerospace carbon epoxy components remains dominated by processes involving prepreg cured in autoclaves. This manufacturing route is expensive, not only because prepreg precursor materials have short shelf lives and require refrigerated storage, but also because large autoclaves carry very high operating costs and are in very intensive usage, with limited worldwide availability. Vacuum Assisted Resin Transfer Moulding (VARTM) is an interesting alternative for the manufacturing of near net-shape components as it reduces the costs related to material storage and removes the need for autoclave cure. The production of parts with complex geometry using VARTM is highly influenced by the kinetics of resin flow into preforms upon infusion, and on optimization of the infusion system for speed, consistency and robustness. In this work, the permeability of carbon fibre textile stacks and of equivalent glass fibre stacks was probed in manufacturing replicate trials, with the aim of bettering the production process. Trials were conducted using a substitute silicon oil infused through glass fibre and carbon preforms to enable capture of the evolving flow fronts on camera. The trials covered the effects of preform geometry, port and vent location, and stitching on resin flow. Tooling necessary for conducting the trials was designed and built. The timing of operations was determined in order to optimise the manufacturing process.
Les enjeux éthiques de la gestion de l’eau – une perspective humaniste chrétienne d’inspiration thomiste
Creators: name: Houle, Emmanuel L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Éthique
Gestion de l'eau
Humanisme chrétien
Thomas d'Aquin

description: Mark Twain aurait affirmé : « Le whisky c'est pour boire. L'eau c'est pour se battre ». La présente thèse traite d’une question précise : quel mode de gestion représente une solution éthique au problème du manque de bonne gestion de l’eau? Tout d'abord, un tableau de la situation mondiale de la gestion de l'eau potable est esquissé. Ensuite suit l’exposition des concepts de base de l’éthique de Thomas d’Aquin : Loi naturelle, bien commun et vertu. Enfin, une application de l’éthique thomiste est faite à travers le prisme de la doctrine sociale de l’Église catholique. La réponse à la question initiale provient d’un parcours philosophique qui part du moyen âge pour en arriver à nos jours.
Impact of the Transition from Pediatric to Adult Medical Care on Health Service Utilization in Inflammatory Bowel Disease (IBD)
Creators: name: Zhao, Xinbei
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: IBD
transition
health
service
utilization

description: OBJECTIVES: Inflammatory bowel disease (IBD) is a chronic condition with increasing pediatric incidence. Transition from pediatric to adult care is associated both with disruption of links with familiar caregivers and differences in health care delivery. This study explored the impact of the transfer from pediatric to adult care on health services utilization for pediatric-onset IBD patients. APPROACH: A population-based retrospective cohort study identified all children diagnosed with IBD 1994-2008 and treated by pediatric gastroenterologists from within Ontario health administrative data. Self-controlled case series analyses compared health services utilization in the 2 years before and after transfer to adult gastroenterologists, with a 6-month washout period at transfer. Outcome evaluated included IBD related/specific hospitalization, emergency department (ED) utilization, outpatient visits, and laboratory utilization. Relative incidence (RI) in the post-transfer was compared to pre-transfer periods using Poisson regression analysis controlling for transfer starting age. Analyses were stratified by IBD types: Crohn’s disease (CD) and ulcerative colitis (UC). RESULTS: 536 patients were included in the study (388 CD, 148 UC). ED utilization rate was higher after transfer for both CD (RI 2.12, 95% CI 1.53-2.93) and UC (RI 2.34, 95% CI 1.09-5.03). Other increases in health care provision included outpatients visits (CD: RI 1.56, 95% CI 1.42-1.72; UC: RI 1.48, 95% CI 1.24-1.76), and laboratory investigations (CD: RI 1.43, 95% CI 1.26-1.63; UC: 1.38, 95% CI 1.13-1.68). There was no statistically significant change in hospitalization (CD: RI 0.70, 95% CI 0.42-1.18; UC: RI 2.41, 95% CI 0.62-9.40). Sensitivity analysis revealed similar results when only the first year post-transfer period was assessed. CONCLUSIONS: In the largest study to date examining the transfer from pediatric to adult IBD care, health services utilization increased significantly in the two years after transfer for measures of access to health care providers. Understanding causation and rigorously evaluated transition programs may help to better manage the resources and meet the needs of pediatric-onset IBD patients.
The Intonational Structure of Singapore English
Creators: name: Chow, Daryl
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Phonology
Prosody
English
Tone

description: This dissertation is a comprehensive description of the structure of the prosody of Singapore English. Using the Prosodic Hierarchy as a framework, each layer of the structure of Singapore English is described in detail. The smallest level described in this dissertation is the syllable, the domain in which the majority of segmental processes occur in Singapore English. The second level is the prosodic word domain, where there is a high tone anchored to the final syllable and a low tone anchored to the left edge, and these tones are shown in this dissertation to be recursive. These tones are independent of stress, which is argued to not exist in Singapore English. The third level is the intonational phrase, where the final syllable carries the boundary tone of the entire intonational phrase, affecting the tones of final particles. There is also a phrase-initial boost on the first prosodic word of the intonational phrase. Markedly absent is any intermediate phrase or domain between the word and intonational phrase, which is argued to not exist in this dissertation. The dissertation ends with a look at the possible origins of the prosody of Singapore English and a consideration of the prosodic systems which may have influenced its development.
Design and Analysis of an Interoperable HLA-based Simulation System over a Cloud Environment
Creators: name: Liu, Dan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: HLA, Distributed simulation, Cloud computing, Interoperability

description: Distributed simulation over Cloud environment is still a new subject. Cloud computing is expected to bring new benefits to conventional distributed simulation, including elasticity on computation resource, cost saving on investment and convenience on service accessibility. A few researches have been done on applying Cloud computing on distributed simulation. However, there are various drawbacks and limitations on those works. Lack of interoperability across Cloud platforms is one of critical drawbacks among them. It can greatly limit the usability and flexibility of distributed simulation over Cloud environment. Based on the investigation on Cloud computing and existing distributed simulation systems over Cloud environment, a novel interoperable HLA-based (High Level Architecture) simulation system over a Cloud environment, ISSC (Interoperable Simulation System over a Cloud Environment), is proposed in this thesis. ISSC aims to address the interoperability issue of simulation system across various Cloud platforms. It employs OCCI and a set of technologies, including Ruby on Rails, OpenVPN and RESTful web services, to build the interoperability across Cloud platforms. It adopts a distributed architecture to construct flexibility and expansibility of the system. The prototype and related experiments performed provides an excellent demonstration that ISSC is a reliable and effective solution on interoperable simulation system over a diverse Cloud environment.
Trust Management and Security Analysis of Opportunistic Routing Protocols in Multihop Wireless Networks
Creators: name: Salehi, Mahmood
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017

description: Routing in wireless sensor, mobile ad-hoc, and vehicular networks is a crucial operation having significantly attracted scientists' attention during the past years. Opportunistic routing, however, is a novel and promising approach, which is still an ongoing research paradigm. The purpose of opportunistic routing protocols is to increase the reliability of delivering data packets to their destination by utilizing the broadcast nature of wireless networks and selecting a set of nodes, instead of only one, as potential next-hop candidates. Apart from the reliability, security and trustworthiness of communications is also a challenging task. More specifically, almost all traditional and opportunistic routing protocols require cooperation of all network nodes to complete the routing process. However, some nodes in the network may be compromised and avoid collaboration with others due to various selfish or malicious motivations. The focus of this thesis is on modeling security challenges and developing trust-based opportunistic routing protocols. This way, communication between nodes will not only benefit from the reliability of opportunistic routing methods, but also from the security of trust and reputation management schemes. For this purpose, a novel trust-based opportunistic routing protocol is proposed that introduces three different candidate selection metrics known as RTOR, TORDP, and GEOTOR. Such metrics have been designed to address specific characteristics of opportunistic routing protocols. In continue, a watchdog mechanism is proposed to assist nodes in monitoring their candidates, recalculating their trust value, and finally replacing malicious candidates with benign ones. Afterwards, an analytical approach is introduced using Discrete-Time Markov Chain to demonstrate the effect of malicious nodes on different parameters of a wireless network that uses opportunistic routing. In this model, a new method of calculating packet drop ratio is introduced to represent the effect of attackers. The model is then applied on different well-known opportunistic routing protocols and results of the model are verified by simulation. Finally, the proposed analytical model is extended to include a defensive mechanism against adversary nodes. In fact, a packet salvaging mechanism is developed through which backup candidates attempt to save some of the maliciously dropped data packets. Different related network parameters such as delivery ratio, salvage ratio, direct-delivery ratio, etc. are then introduced, calculated, and reported using the introduced model.
Drug Safety Advisories : A need for international coordination
Creators: name: Therapeutics Initiative (University Of British Columbia)
Publisher: name: The University of British Columbia
Year: 2023

description: Therapeutics Letter 128 highlights the need for international coordination on drug safety advisories. Conclusions: Observational studies have identified signals of serious harms from long-term PPI exposure, including an increased risk of death. Even large RCTs may not detect these, if exposure or follow-up are insufficiently long. The COMPASS trial findings are not inconsistent with contemporaneous findings from observational studies. Clinicians and patienConclusions Better awareness of drug safety advisories from their own and other countries could help prescribers and patients seek the safest available drugs. When drug safety warnings differ, clinicians and the public need to know why. Regulators should provide the underlying rationale and an international context when issuing new drug safety warnings.ts can reverse the relentless expansion of long-term PPI exposure by reviewing indications and considering potential harms as well as benefits.
Exploring the Experiences of Infertile Arab Immigrant Women: A Qualitative Study
Creators: name: Jrade, Lyne
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Women
Reproductive
Health
Infertility
Arab
Immigrant
Qualitative
Ontario

description: Background: Infertility rates in the Middle East and North Africa are among the highest worldwide. Despite its elevated prevalence among men and women, infertility is mainly blamed on women’s reproductive health failures. Consequently, infertility threatens women’s social and marital security, social power, and status in society. In Canada, the Arab population constitutes the second largest group of newcomers, but very little research has explored Arab immigrant women’s experiences with and access to comprehensive reproductive health services. Objectives: This project aimed to fill a gap in the literature on reproductive health in Ontario. This study explored: 1) Arab women’s experiences with infertility and infertility-related services in Ontario; 2) the barriers these women face when seeking these services; and 3) possible ways infertility-related information and services could be improved. Methods: This qualitative study consisted of in-depth interviews with Arab immigrant women and interviews with key informants. We used a multi-modal recruitment strategy including social media ads, flyers, advertisements through community organizations, and an Arabic-language radiobroadcast. We analyzed both components for content and themes using deductive and inductive techniques. Results: Participants struggled with primary infertility, mainly due to polycystic ovarian syndrome or endometriosis. Women identified cost, socio-cultural dynamics, stigma, and embarrassment as barriers to seeking treatment. Women described existing services as lacking comprehensive information, cultural sensitivity, and emotional support. Conclusions: Our findings suggest that Arab immigrants face barriers in accessing infertility care in Ontario. These services can be improved through engaging in education and awareness raising efforts, providing psychosocial support services, and building bridges between organizations and the community.
Connectivity of dI3 Interneurons In the Development of Mice Spinal Cord
Creators: name: Farah, Carl
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Spinal Cord
Connectivity
Interneuron
Development

description: Maturation of motor control, including movements that can be autonomously generated by spinal circuits, relies on the development of key inputs to spinal circuitry. In particular, the development of supraspinal, sensory and motor fibers come together to form organized spinal circuits capable of producing skilled movements that are volitionally controlled. Primitive reflexes such as the palmar grasp reflex (PGR) are known to disappear during development; presumably giving way to more volitional control of hand grasping. However, the underlying changes to the spinal circuitry responsible for this transition remain to be determined. dI3 INs, a class of dorsal spinal interneurons, have positioned themselves as key mediators of reflexive grasping in early development and grasping in adult mice. The first aim of the study focused on determining the developmental time point at which the PGR disappeared. Our studies demonstrated that the PGR was lost by the third week of development. The second aim of this study focused on identifying changes in sensory innervation, presynaptic inhibition and supraspinal excitation to dI3 INs that might account for the loss of this reflex. Our studies demonstrated that while sensory innervation remained constant during development, presynaptic inhibitory terminals onto sensory afferents were found to increase during development. In addition, we report that dI3 INs receive decreasing corticospinal (CST) input during development. While these developmental changes do not fully account for the disappearance of the PGR, they provide valuable insights into how a reflex centered on a particular population develops.
Children's Rights: Making Canada Work Better for Young People. A Discussion Paper.
Creators: name: Paré, Mona
name: Vandergrift, Kathy
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017

description: Children’s rights could be an asset for federalism, rather than using federalism as an excuse for lack of implementation or a shield to avoid accountability. This hypothesis was the focus for discussion at a special event to honour the 25th Anniversary of Canada’s ratification of the Convention on the Rights of the Child. The goal is improving implementation across the different jurisdictions that are part of the federal state in Canada. The panel discussion and workshop were sponsored by the Canadian Coalition for the Rights of Children, the Interdisciplinary Research Laboratory on the Rights of the Child (IRLRC) and the Human Rights Education and Resource Center at the University of Ottawa. A discussion paper, distributed in advance, identified features of a children’s rights-based approach that could improve governance for children and issues for further discussion.
Additional file 1 of Indole-3-propionic acid promotes hepatic stellate cells inactivation
Creators: name: Ilha, Mariana
name: Sehgal, Ratika
name: Matilainen, Johanna
name: Rilla, Kirsi
name: Kaminska, Dorota
name: Gandhi, Shrey
name: Männistö, Ville
name: Ling, Charlotte
name: Romeo, Stefano
name: Pajukanta, Päivi
name: Pirinen, Eija
name: Virtanen, Kirsi A.
name: Pietiläinen, Kirsi H.
name: Vaittinen, Maija
name: Pihlajamäki, Jussi
Publisher: name: figshare
Year: 2025
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1.
A Microfluidic Device for Transfection of Mammalian Cells Using Adjustable Shear Stress
Creators: name: Cencen, Veronika
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Microfluidics
Transfection
Impedance
Photolithograpy
PAH
FITC

description: Microfluidic technology is a rapidly progressing tool in biomedical engineering. Microfluidic devices are appreciated for their simplicity and production efficiency potential. Our research focuses on developing a microfluidic device capable of transfecting cells by applying shear stress to cause temporary membrane damage. The advantage of this physical method of transfection is the possibility of incorporating large molecules that cannot be inserted with more traditional chemical transfection methods, while avoiding the large fall in viability seen with other physical methods such as electroporation. Unlike previous groups, our device incorporates the use of microfluidic valves to allow tunability, and impedance sensing for cell membrane damage analysis. We achieve (95±5)% cell viability and up to (68±5)% efficiency in transfecting 3T3 cells with DNA-sized molecules. In future stages, we intend to add the device onto an existing cell-encapsulation device that is tasked with preparing therapeutic cells to be used in regenerative medicine applications.