cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Rap1 and Canoe/afadin are essential for establishment of apical-basal polarity in the Drosophila embryo
Creators: name: Harris, Nathan J.
name: Choi, Wangsun
name: Peifer, Mark
name: Sumigray, Kaelyn D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The small GTPase Rap1 and the actin-junctional linker protein Canoe/afadin are essential for the initial establishment of polarity in Drosophila, acting upstream of Bazooka/Par3 and the adherens junctions. However, feedback and cross-regulation occur, so polarity establishment is regulated by a network of proteins rather than a linear pathway.The establishment and maintenance of apical–basal cell polarity is critical for assembling epithelia and maintaining organ architecture. Drosophila embryos provide a superb model. In the current view, apically positioned Bazooka/Par3 is the initial polarity cue as cells form during cellularization. Bazooka then helps to position both adherens junctions and atypical protein kinase C (aPKC). Although a polarized cytoskeleton is critical for Bazooka positioning, proteins mediating this remained unknown. We found that the small GTPase Rap1 and the actin-junctional linker Canoe/afadin are essential for polarity establishment, as both adherens junctions and Bazooka are mispositioned in their absence. Rap1 and Canoe do not simply organize the cytoskeleton, as actin and microtubules become properly polarized in their absence. Canoe can recruit Bazooka when ectopically expressed, but they do not obligatorily colocalize. Rap1 and Canoe play continuing roles in Bazooka localization during gastrulation, but other polarity cues partially restore apical Bazooka in the absence of Rap1 or Canoe. We next tested the current linear model for polarity establishment. Both Bazooka and aPKC regulate Canoe localization despite being “downstream” of Canoe. Further, Rap1, Bazooka, and aPKC, but not Canoe, regulate columnar cell shape. These data reshape our view, suggesting that polarity establishment is regulated by a protein network rather than a linear pathway.
On $n$-norm preservers and the Aleksandrov conservative $n$-distance problem
Creators: name: Gehér, Gy. P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Metric Geometry (math.MG)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: (Primary) 51M25, 51K05, (Secondary) 46B04, 46B20

description: The goal of this paper is to point out that the results obtained in the recent papers [7,8,10,11] can be seriously strengthened in the sense that we can significantly relax the assumptions of the main results so that we still get the same conclusions. In order to do this first, we prove that for $n \geq 3$ any transformation which preserves the $n$-norm of any $n$ vectors is automatically plus-minus linear. This will give a re-proof of the well-known Mazur--Ulam-type result that every $n$-isometry is automatically affine ($n \geq 2$) which was proven in several papers, e.g. in [9]. Second, following the work of Rassias and Šemrl [23], we provide the solution of a natural Aleksandrov-type problem in $n$-normed spaces, namely, we show that every surjective transformation which preserves the unit $n$-distance in both directions ($n\geq 2$) is automatically an $n$-isometry.
The Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins
Creators: name: Trepte, Philipp
name: Rena, Hong Yu
name: Cyr, Douglas M.
name: Wolfe, Katie J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Escape of aberrant proteins from protein quality control leads to accumulation of toxic protein species. Sti1 interacts with Hsp70 to mediate spatial PQC of amyloid-like proteins by regulating their distribution in different intracellular protein-handling depots. Sti1 suppresses proteotoxicity by targeting amyloid-like proteins to perinuclear foci.Conformational diseases are associated with the conversion of normal proteins into aggregation-prone toxic conformers with structures similar to that of β-amyloid. Spatial distribution of amyloid-like proteins into intracellular quality control centers can be beneficial, but cellular mechanisms for protective aggregation remain unclear. We used a high-copy suppressor screen in yeast to identify roles for the Hsp70 system in spatial organization of toxic polyglutamine-expanded Huntingtin (Huntingtin with 103Q glutamine stretch [Htt103Q]) into benign assemblies. Under toxic conditions, Htt103Q accumulates in unassembled states and speckled cytosolic foci. Subtle modulation of Sti1 activity reciprocally affects Htt toxicity and the packaging of Htt103Q into foci. Loss of Sti1 exacerbates Htt toxicity and hinders foci formation, whereas elevation of Sti1 suppresses Htt toxicity while organizing small Htt103Q foci into larger assemblies. Sti1 also suppresses cytotoxicity of the glutamine-rich yeast prion [RNQ+] while reorganizing speckled Rnq1–monomeric red fluorescent protein into distinct foci. Sti1-inducible foci are perinuclear and contain proteins that are bound by the amyloid indicator dye thioflavin-T. Sti1 is an Hsp70 cochaperone that regulates the spatial organization of amyloid-like proteins in the cytosol and thereby buffers proteotoxicity caused by amyloid-like proteins.
title: A simulation framework with anthropomorphic head model for virtual clinical trials in dental CBCT imaging
Creators: name: Merken, Karen
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Radiation physics
subject: Cone beam CT
subject: Computer Applications-Virtual imaging
subject: Physics
subject: Artifacts
subject: Quality assurance

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Over the past two decades, the use of cone beam computed tomography (CBCT) imaging has become increasingly common for various dental applications, including endodontics, implant placement, orthodontic planning and maxillofacial surgery, overcoming...
title: Comparison of Whole-Body MRI and 18F-FDG PET-CT for response assessment in patients with multiple myeloma.
Creators: name: PATERNAIN NUIN, ALBERTO
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Bones
subject: Haematologic
subject: Oncology
subject: MR-Diffusion/Perfusion
subject: PET-CT
subject: Comparative studies
subject: Diagnostic procedure
subject: Imaging sequences
subject: Cancer
subject: Haematologic diseases

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: To compare the response assessment in patients with multiple myeloma obtained by Whole-Body MRI after applying the MY-RADS (Myeloma Response Assessment and Diagnosis System), with 18 F-FDG PET-CT after the application of IMPETUS (Italian Myeloma...
LUCERNE ITALICHE REPUBBLICANE. LE FORME BICONICA E CILINDRICA: PROPOSTE PER UNA TIPOLOGIA.
Creators: name: FORLANO, GAIA
Publisher: name: Universit� degli Studi di Milano
Year: 2016

description: La ricerca si � focalizzata sullo studio delle lucerne italiche di epoca repubblicana di forma biconica e cilindrica, al fine di sistematizzare, in due tipologie ad albero, tipi e varianti regionali e fornire una seriazione che prenda in considerazione sia gli aspetti morfologici che i centri di produzione, la cronologia, l'area e le dinamiche di diffusione di ogni singolo tipo o variante identificati. Lo studio ha coperto tutto il territorio italiano ed ha portato alla redazione di schede dei contesti di rinvenimento, suddivise in tre sezioni geografiche (Centro, Sud e Nord Italia), nelle quali sono stati riportati sia i dati ricavati dall'analisi del materiale edito che quelli provenienti dallo studio di alcuni reperti inediti.
The yeast dynein Dyn2-Pac11 complex is a dynein dimerization/processivity factor: structural and single-molecule characterization
Creators: name: Nicholas, Matthew P.
name: Romes, Erin M.
name: Gennerich, Arne
name: Rao, Lu
name: Brenner, Sibylle
name: Tripathy, Ashutosh
name: Slep, Kevin C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Studying the role of accessory chains in dynein single-molecule motility shows that the dynein light chain (LC) and intermediate chain (IC) promote motor dimerization, increase velocity, and potentiate processivity. The crystal structure of the yeast LC–IC complex is determined, and the interaction is biochemically characterized.Cytoplasmic dynein is the major microtubule minus end–directed motor. Although studies have probed the mechanism of the C-terminal motor domain, if and how dynein's N-terminal tail and the accessory chains it binds regulate motor activity remain to be determined. Here, we investigate the structure and function of the Saccharomyces cerevisiae dynein light (Dyn2) and intermediate (Pac11) chains in dynein heavy chain (Dyn1) movement. We present the crystal structure of a Dyn2-Pac11 complex, showing Dyn2-mediated Pac11 dimerization. To determine the molecular effects of Dyn2 and Pac11 on Dyn1 function, we generated dyn2Δ and dyn2Δpac11Δ strains and analyzed Dyn1 single-molecule motor activity. We find that the Dyn2-Pac11 complex promotes Dyn1 homodimerization and potentiates processivity. The absence of Dyn2 and Pac11 yields motors with decreased velocity, dramatically reduced processivity, increased monomerization, aggregation, and immobility as determined by single-molecule measurements. Deleting dyn2 significantly reduces Pac11-Dyn1 complex formation, yielding Dyn1 motors with activity similar to Dyn1 from the dyn2Δpac11Δ strain. Of interest, motor phenotypes resulting from Dyn2-Pac11 complex depletion bear similarity to a point mutation in the mammalian dynein N-terminal tail (Loa), highlighting this region as a conserved, regulatory motor element.
title: Vascular disorders of the small intestine in patients of the Emergency Room of University Clinical Centre of Serbia
Creators: name: Spasojević, Natalija
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Emergency
subject: Gastrointestinal tract
subject: CT
subject: Ultrasound
subject: Diagnostic procedure
subject: Surgery
subject: Obstruction / Occlusion

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Vascular disorders of the small intestine are a relatively rare cause of the patient's reporting in the emergency department and often represent a diagnostic dilemma. Initial radiological diagnosis in these clinical conditions include X-ray of...
(401573) James Cochran
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
DENSITA� MINERALE OSSEA, QUALITA� DELL�OSSO E RISCHIO DI FRATTURA NEL DIABETE MELLITO TIPO 2:RUOLO DELL�ASSE IPOTALAMO-IPOFISI-SURRENE EDELLA SENSIBILITA� AI GLUCOCORTICOIDI
Creators: name: ZHUKOUSKAYA, VOLHA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: Introduzione: Nel Diabete Mellito di tipo 2 (T2D) vi � un aumento del rischio di frattura vertebrale (VFx). L?asse ipotalamo-ipofisi-surrene (HPA) sembra attivato nel T2D scompensato e la sensibilit� ai glucocorticoidi (GC) sembra influenzare la densit� minerale ossea (DMO) nei soggetti con osteoporosi. Obiettivo: Valutare il ruolo dell?asse HPA e della sensibilit� ai GC, mediante i polimorfismi (SNPs) BclI e N363S del recettore GC e l?attivit� della 11?idrossisteroidodeidrogenasi tipo 2, (11HSD2) sulla DMO, VFx e qualit� dell?osso valutata mediante il Trabecular Bone Score, (TBS), in donne con T2D compensato in menopausa. Materiali/metodi: in 92 donne con T2D (emoglobina glicata 6.7�1.2%) e 92 controlli, paragonabili per et�, sesso, BMI, abbiamo valutato: 1) metabolismo calcio-fosforo, livelli ACTH, cortisoluria 24h (CLU), cortisone (CoLU) su urine 24h, cortisolo dopo 1 mg desametasone h 23 (1mgDST); 2) attivit� del 11HSD2 (rapporto CLU/CoLU), SNPs di BclI e N363S; 3) DMO (Z-score, lombare, LS e collo femorale, FN) e TBS (Z-score) mediante DXA e VFx mediante morfometria. Risultati: Le pazienti con T2D hanno mostrato, rispetto ai controlli, VFx aumentate (34.8 vs 19.6 %, rispettivamente, p=0.031) e DMO maggiore (LS 0.81�0.47 vs 0.17�1.32, p=0.002; FN 0.63�0.99 vs 0.04�0.94, p=0.000), mentre TBS, attivit� HPA e 11HSD2, e prevalenza degli SNPs di BclI e N363S sono risultate paragonabili. Le pazienti con T2D e VFx hanno mostrato un?aumentata frequenza dello SNPs N363S in eterozigosi (15.6%) e DMO e TBS minori rispetto a quelle senza VFx (3.3%, p=0.047), ma simili secrezione di cortisolo, attivit� 11HSD2 e frequenza dello SNP BclI. Lo stesso � risultato nei soggetti di controllo. Le VFx sono risultate associate al T2D (OR=2.6, 95%CI 1.2-5.5, p=0.015) ed allo SNP N363S in eterozigosi (OR=8.5, 95%CI 2.3-31.1, p=0.01). Conclusioni: Nel T2D compensato la prevalenza di VFx � aumentata e, come nella popolazione generale, sembra associata ad un?aumentata sensibilit� ai GC.
Thermal conductivity of the one-dimensional Fermi-Hubbard model
Creators: name: Karrasch, C.
name: Kennes, D. M.
name: Heidrich-Meisner, F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study the thermal conductivity of the one-dimensional Fermi-Hubbard model at finite temperature using a density matrix renormalization group approach. The integrability of this model gives rise to ballistic thermal transport. We calculate the temperature dependence of the thermal Drude weight at half filling for various interactions and moreover, we compute its filling dependence at infinite temperature. The finite-frequency contributions originating from the fact that the energy current is not a conserved quantity are investigated as well. We report evidence that breaking the integrability through a nearest-neighbor interaction leads to vanishing Drude weights and diffusive energy transport. Moreover, we demonstrate that energy spreads ballistically in local quenches with initially inhomogeneous energy density profiles in the integrable case. We discuss the relevance of our results for thermalization in ultra-cold quantum gas experiments and for transport measurements with quasi-one dimensional materials.
Torsion of a cylinder of partially molten rock with a spherical inclusion: theory and simulation
Creators: name: Alisic, Laura
name: Rhebergen, Sander
name: Rudge, John F.
name: Katz, Richard F.
name: Wells, Garth N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences
subject: 76T99, 86A04

description: The processes that are involved in migration and extraction of melt from the mantle are not yet fully understood. Gaining a better understanding of material properties of partially molten rock could help shed light on the behavior of melt on larger scales in the mantle. In this study, we simulate three-dimensional torsional deformation of a partially molten rock that contains a rigid, spherical inclusion. We compare the computed porosity patterns to those found in recent laboratory experiments. The laboratory experiments show emergence of melt-rich bands throughout the rock sample, and pressure shadows around the inclusion. The numerical model displays similar melt-rich bands only for a small bulk-to-shear-viscosity ratio (five or less). The results are consistent with earlier two-dimensional numerical simulations; however, we show that it is easier to form melt-rich bands in three dimensions compared to two. The addition of strain-rate dependence of the viscosity causes a distinct change in the shape of pressure shadows around the inclusion. This change in shape presents an opportunity for experimentalists to identify the strain-rate dependence and therefore the dominant deformation mechanism in torsion experiments with inclusions.
VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1
Creators: name: Sopha, Pattarawut
name: Houck, Scott A.
name: Cyr, Douglas M.
name: Van Goor, Fredrick
name: De La Rosa, Oxana
name: Hoffman, Beth J.
name: Ren, Hong Yu
name: Grove, Diane E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Cystic fibrosis (CF) is a fatal genetic disorder associated with defective hydration of lung airways due to the loss of chloride transport through the CF transmembrane conductance regulator protein (CFTR). CFTR contains two membrane-spanning domains (MSDs), two nucleotide-binding domains (NBDs), and a regulatory domain, and its channel assembly requires multiple interdomain contacts. The most common CF-causing mutation, F508del, occurs in NBD1 and results in misfolding and premature degradation of F508del-CFTR. VX-809 is an investigational CFTR corrector that partially restores CFTR function in people who are homozygous for F508del-CFTR. To identify the folding defect(s) in F508del-CFTR that must be repaired to treat CF, we explored the mechanism of VX-809 action. VX-809 stabilized an N-terminal domain in CFTR that contains only MSD1 and efficaciously restored function to CFTR forms that have missense mutations in MSD1. The action of VX-809 on MSD1 appears to suppress folding defects in F508del-CFTR by enhancing interactions among the NBD1, MSD1, and MSD2 domains. The ability of VX-809 to correct F508del-CFTR is enhanced when combined with mutations that improve F508del-NBD1 interaction with MSD2. These data suggest that the use of VX-809 in combination with an additional CFTR corrector that suppresses folding defects downstream of MSD1 may further enhance CFTR function in people with F508del-CFTR.
Outcomes of the My Therapy self-management program in people admitted for rehabilitation: A stepped wedge cluster randomized clinical trial
Creators: name: Brusco, Natasha
name: Ekegren, Christina L
name: Morris, Meg
name: Hill, Keith D
name: Lee, Annemarie L
name: Somerville, Lisa
name: Lannin, Natasha
name: Abdelmotaleb, Rania
name: Callaway, Libby
name: Whittaker, Sara L
name: Taylor, Nicholas
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 4201
subject: Allied health and rehabilitation science

description: Background: Self-management programs can increase the time spent on prescribed therapeutic exercises and activities in rehabilitation inpatients, which has been associated with better functional outcomes and shorter hospital stays. Objectives: To determine whether implementation of a self-management program (‘My Therapy’) improves functional independence relative to routine care in people admitted for physical rehabilitation. Methods: This stepped wedge, cluster randomized trial was conducted over 54 weeks (9 periods of 6-week duration, April 2021 - April 2022) across 9 clusters (general rehabilitation wards) within 4 hospitals (Victoria, Australia). We included all adults (≥18 years) admitted for rehabilitation to participating wards. The intervention included routine care plus ‘My Therapy’, comprising a sub-set of exercises and activities from supervised sessions which could be performed safely, without supervision or assistance. The primary outcomes were the proportion of participants achieving a minimal clinically important difference (MCID) in the Functional Independence Measure, (FIM™) and change in total FIM™ score from admission to discharge. Results: 2550 participants (62 % women) were recruited (control: n = 1458, intervention: n = 1092), with mean (SD) age 77 (13) years and 37 % orthopedic diagnosis. Under intervention conditions, participants reported a mean (SD) of 29 (21) minutes/day of self-directed therapy, compared to 4 (SD 14) minutes/day, under control conditions. There was no evidence of a difference between control and intervention conditions in the odds of achieving an MCID in FIM™ (adjusted odds ratio 0.93, 95 % CI 0.65 to 1.31), or in the change in FIM™ score (adjusted mean difference: -0.27 units, 95 % CI -2.67 to 2.13). Conclusions: My Therapy was delivered safely to a large, diverse sample of participants admitted for rehabilitation, with an increase in daily rehabilitation dosage. However, given the lack of difference in functional improvement with participation in My Therapy, self-management programs may need to be supplemented with other strategies to improve function in people admitted for rehabilitation. Trial registration: Australian New Zealand Clinical Trials Registry (ACTRN12621000313831), https://www.anzctr.org.au/
title: Relax: It’s just a normal variant
Creators: name: Sharma, Shaurya
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Anatomy
subject: CNS
subject: Neuroradiology brain
subject: CT
subject: MR
subject: Education
subject: Calcifications / Calculi
subject: Cysts
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To identify normal variants on brain imaging To enlist the disease entities they may mimic and to distinguish normal variants from pathological conditions, To discuss the further management of aforementioned incidental findings, if...
Food Marketing Review, 1985
Creators: name: Economic Research Service, USDA
name: Economic Research Service, USDA
Publisher: name: Unknown
Year: 1986
Subjects: subject: Food Consumption/Nutrition/Food Safety
subject: Industrial Organization
subject: Marketing
subject: FOS: Economics and business
subject: Food service
subject: retailing
subject: manufacturing
subject: wholesaling
subject: marketing

description: Sales in the U.S. food marketing system reached an estimated half a trillion dollars in 1985, a 3.5-percent real increase above 1984, compared with the 2.3-percent real increase in gross national product. The food marketing system comprised over 1 million firms in 1985 in food manufacturing, wholesaling, retailing, and service. Only food service shows a long-term increase in total number of firms. Because the food marketing system benefits from a low-inflation economy which allows costs to be held down, 1985 was a stable year as farm prices fell and wages and marketing costs increased moderately. This report analyzes these and other developments, structural changes, and the outlook for the U.S. food marketing system.
(401574) James Bell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Optically Visible Post-AGB Stars, Post-RGB Stars and Young Stellar Objects in the Large Magellanic Cloud
Creators: name: Kamath, Devika
name: Wood, Peter R.
name: Van Winckel, Hans
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We have carried out a search for optically visible post-Asymptotic Giant Branch (post-AGB) stars in the Large Magellanic Cloud (LMC). First, we selected candidates with a mid-IR excess and then obtained their optical spectra. We disentangled contaminants with unique spectra such as M-stars, C-stars, planetary nebulae, quasi-stellar objects and background galaxies. Subsequently, we performed a detailed spectroscopic analysis of the remaining candidates to estimate their stellar parameters such as effective temperature, surface gravity (log g), metallicity ([Fe/H]), reddening and their luminosities. This resulted in a sample of 35 likely post-AGB candidates with late-G to late-A spectral types, low log g, and [Fe/H] < -0.5. Furthermore, our study confirmed the existence of the dusty post-Red Giant Branch (post-RGB) stars, discovered previously in our SMC survey, by revealing 119 such objects in the LMC. These objects have mid-IR excesses and stellar parameters (Teff, log g, [Fe/H]) similar to those of post-AGB stars except that their luminosities (< 2500 Lsun), and hence masses and radii, are lower. These post-RGB stars are likely to be products of binary interaction on the RGB. The post-AGB and post-RGB objects show SED properties similar to the Galactic post-AGB stars, where some have a surrounding circumstellar shell, while some others have a surrounding stable disc similar to the Galactic post-AGB binaries. This study also resulted in a new sample of 162 young stellar objects, identified based on a robust log g criterion. Other interesting outcomes include objects with an UV continuum and an emission line spectrum; luminous supergiants; hot main-sequence stars; and 15 B[e] star candidates, 12 of which are newly discovered in this study.
description: Published in MNRAS 64 pages, 14 figures, 8 tables, 3 appendices. arXiv admin note: text overlap with arXiv:1402.5954
title: MINOCA. Beyond acute myocardial infarction
Creators: name: Iniesta González, Maria Cristina
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiac
subject: MR
subject: Diagnostic procedure
subject: Inflammation

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Define MINOCA and the diagnostic criteria, as well as its ischemic and non-ischemic mechanisms. Highlight the importance of cardiac magnetic resonance (CMR) for early diagnosis. Prepare an adequate study protocol. Describe the main pathologies and...
title: Applications of generative adversarial networks in radiology: a brief overview
Creators: name: Laino, Maria Elena
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Artificial Intelligence
subject: CAD
subject: CT
subject: MR
subject: CAD
subject: Artifacts
subject: Dosimetric comparison
subject: Image verification

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: In this exhibit, we will provide an introduction to Generative adversarial networks (GANs) in radiology, focusing on their clinical potential as well as the pitfalls clinicians should be aware...
Nuclear energy release from fragmentation
Creators: name: Li, Cheng
name: Souza, S. R.
name: Tsang, M. B.
name: Zhang, Feng-Shou
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Nuclear energy released by splitting Uranium and Thorium isotopes into two, three, four, up to eight fragments with nearly equal size are studied. We found that the energy released come from equally splitting the $^{235,238}$U and $^{230,232}$Th nuclei into to three fragments is largest. The statistical multifragmentation model is employed to calculate the probability of different breakup channels for the excited nuclei. Weighing the the probability distributions of fragments multiplicity at different excitation energies for the $^{238}$U nucleus, we found that an excitation energy between 1.2 and 2 MeV/u is optimal for the $^{235}$U, $^{238}$U, $^{230}$Th and $^{232}$Th nuclei to release nuclear energy of about 0.7-0.75 MeV/u.
A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis
Creators: name: Mousley, Carl J.
name: Ivanova, Pavlina T.
name: Verdaasdonk, Jolien
name: Temple, Brenda R.S.
name: Bloom, Kerry S.
name: Leiker, Thomas J.
name: Bankaitis, Vytas A.
name: Ortlund, Eric A.
name: Lin, Coney Pei Chen
name: Eckert, Debra M.
name: Neiman, Aaron M.
name: Murphy, Robert C.
name: Brown, H. Alex
name: Duncan, Mara C.
name: Nile, Aaron H.
name: Myers, David S.
name: Pathak, Manish C.
name: Ren, Jihui
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The Sec14-like phosphatidylinositol transfer protein Sfh3 associates with bulk LDs in vegetative cells but targets to a neutral lipid hydrolase-rich LD pool during sporulation. Sfh3 inhibits LD utilization by a PtdIns-4-phosphate–dependent mechanism, and this inhibition prevents prospore membrane biogenesis in sporulating cells.Lipid droplet (LD) utilization is an important cellular activity that regulates energy balance and release of lipid second messengers. Because fatty acids exhibit both beneficial and toxic properties, their release from LDs must be controlled. Here we demonstrate that yeast Sfh3, an unusual Sec14-like phosphatidylinositol transfer protein, is an LD-associated protein that inhibits lipid mobilization from these particles. We further document a complex biochemical diversification of LDs during sporulation in which Sfh3 and select other LD proteins redistribute into discrete LD subpopulations. The data show that Sfh3 modulates the efficiency with which a neutral lipid hydrolase-rich LD subclass is consumed during biogenesis of specialized membrane envelopes that package replicated haploid meiotic genomes. These results present novel insights into the interface between phosphoinositide signaling and developmental regulation of LD metabolism and unveil meiosis-specific aspects of Sfh3 (and phosphoinositide) biology that are invisible to contemporary haploid-centric cell biological, proteomic, and functional genomics approaches.
title: Radiotherapy Techniques in Irradiation of Breast Cancer: A Dosimetric Comparison
Creators: name: Vaz, Bruna
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Radiographers
subject: Radioprotection / Radiation dose
subject: Cone beam CT
subject: Experimental
subject: Radiation therapy / Oncology
subject: Technical aspects
subject: Technology assessment
subject: Dosimetric comparison

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Radiotherapy in breast cancer is increasingly a common treatment and is mostly prescribed to cancer patients after surgery in an adjuvant treatment. Although Three-dimensional Conformal Radiotherapy (3D-CRT) has been more commonly used in breast...
Products of ideals may not be Golod
Creators: name: De Stefani, Alessandro
Publisher: name: arXiv
Year: 2015
Subjects: subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: Primary 13A02, Secondary 13D40

description: We exhibit an example of a product of two proper monomial ideals such that the residue class ring is not Golod. We also discuss the strongly Golod property for rational powers of monomial ideals, and introduce some sufficient conditions for weak Golodness of monomial ideals. Along the way, we ask some related questions.
description: 18 pages, minor changes from first version
Ena/VASP regulates mDia2-initiated filopodial length, dynamics, and function
Creators: name: Barzik, Melanie
name: Gertler, Frank B.
name: Gupton, Stephanie L.
name: McClain, Leslie M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Filopodia are actin-based cell extensions that contribute to cell adhesion and spreading. The cytoskeleton regulators mDia2 and VASP have distinct roles in filopodia assembly and function, and VASP controls the length, dynamics, stability, and integrin-dependent adhesion of filopodia formed by mDia2.Filopodia are long plasma membrane extensions involved in the formation of adhesive, contractile, and protrusive actin-based structures in spreading and migrating cells. Whether filopodia formed by different molecular mechanisms equally support these cellular functions is unresolved. We used Enabled/vasodilator-stimulated phosphoprotein (Ena/VASP)–deficient MVD7 fibroblasts, which are also devoid of endogenous mDia2, as a model system to investigate how these different actin regulatory proteins affect filopodia morphology and dynamics independently of one another. Filopodia initiated by either Ena/VASP or mDia2 contained similar molecular inventory but differed significantly in parameters such as number, length, F-actin organization, lifetime, and protrusive persistence. Moreover, in the absence of Ena/VASP, filopodia generated by mDia2 did not support initiation of integrin-dependent signaling cascades required for adhesion and subsequent lamellipodial extension, thereby causing a defect in early cell spreading. Coexpression of VASP with constitutively active mDia2M/A rescued these early adhesion defects. We conclude that Ena/VASP and mDia2 support the formation of filopodia with significantly distinct properties and that Ena/VASP regulates mDia2-initiated filopodial morphology, dynamics, and function.
The Abl/Enabled signaling pathway regulates Golgi architecture in Drosophila photoreceptor neurons
Creators: name: Kannan, Ramakrishnan
name: Wincovitch, Stephen
name: Kuzina, Irina
name: Giniger, Edward
name: Nowotarski, Stephanie H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The Abl tyrosine kinase signaling pathway, including its key effector, the actin regulatory protein Enabled, controls the fragmentation state and subcellular localization of the Golgi compartment in Drosophila photoreceptor neurons via Abl/Enabled-dependent control of actin organization.The Golgi apparatus is optimized separately in different tissues for efficient protein trafficking, but we know little of how cell signaling shapes this organelle. We now find that the Abl tyrosine kinase signaling pathway controls the architecture of the Golgi complex in Drosophila photoreceptor (PR) neurons. The Abl effector, Enabled (Ena), selectively labels the cis-Golgi in developing PRs. Overexpression or loss of function of Ena increases the number of cis- and trans-Golgi cisternae per cell, and Ena overexpression also redistributes Golgi to the most basal portion of the cell soma. Loss of Abl or its upstream regulator, the adaptor protein Disabled, lead to the same alterations of Golgi as does overexpression of Ena. The increase in Golgi number in Abl mutants arises in part from increased frequency of Golgi fission events and a decrease in fusions, as revealed by live imaging. Finally, we demonstrate that the effects of Abl signaling on Golgi are mediated via regulation of the actin cytoskeleton. Together, these data reveal a direct link between cell signaling and Golgi architecture. Moreover, they raise the possibility that some of the effects of Abl signaling may arise, in part, from alterations of protein trafficking and secretion.
title: Isolated Night Sweats Are Not A Justification For Full-body Computed Tomography (CT)
Creators: name: O'Donnell, Ciara
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Haematologic
subject: CT
subject: Audit and standards
subject: Haematologic diseases

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: The purpose of this quality improvement project is to assess the appropriateness of full-body CT requests when patients present with 'sweats', either in isolation or with other symptoms, and also to determine whether local and national guideline...
A counterexample to a conjecture of Ding
Creators: name: De Stefani, Alessandro
Publisher: name: arXiv
Year: 2015
Subjects: subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: Primary 13H10, Secondary 13C05, 13C14

description: We give a counterexample to a conjecture posed by S. Ding regarding the index of a Gorenstein local ring by exhibiting several examples of one dimensional local complete intersections of embedding dimension three with index 5 and generalized Löewy length 6.
description: 9 pages, a few changes from the first version
Comets as collisional fragments of a primordial planetesimal disk
Creators: name: Morbidelli, Alessandro
name: Rickman, Hans
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The Rosetta mission and its exquisite measurements have revived the debate on whether comets are pristine planetesimals or collisionally evolved objects. We investigate the collisional evolution experienced by the precursors of current comet nuclei during the early stages of the Solar System, in the context of the so-called "Nice Model". We consider two environments for the collisional evolution: (1) the trans-planetary planetesimal disk, from the time of gas removal until the disk was dispersed by the migration of the ice giants, and (2) the dispersing disk during the time that the scattered disk was formed. Simulations have been performed, using different methods in the two cases, to find the number of destructive collisions typically experienced by a comet nucleus of 2km radius. In the widely accepted scenario, where the dispersal of the planetesimal disk occurred at the time of the Late Heavy Bombardment about 4Gy ago, comet-sized planetesimals have a very small chance to survive against destructive collisions in the disk. On the extreme assumption that the disk was dispersed directly upon gas removal, there is a chance for a significant fraction of the planetesimals to remain intact. However, these survivors would still bear the marks of many non-destructive impacts. Thus, the Nice Model of Solar System evolution predicts that typical km-sized comet nuclei are predominantly fragments resulting from collisions experienced by larger parent bodies. An important goal for further research is to investigate, whether the observed properties of comet nuclei are compatible with such a collisional origin.
description: in press in Astronomy and Astrophysics
(401570) George Todd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Cardiac Masses: the role of Cardiac Magnetic Resonance
Creators: name: cesarotto, matteo
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiac
subject: MR physics
subject: Oncology
subject: MR
subject: Computer Applications-Detection, diagnosis
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To describe Cardiac Magnetic Resonance (CMR) protocol and different features of cardiac...
Our Mabel. Our Voice: Through Life Story One Aboriginal Family Writes for Self-Love, Justice and Reconciliation
Creators: name: Walsh, Jacinta Lee
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 440509
subject: Women's studies (incl. girls' studies)
classificationCode: 310408
subject: Life histories
classificationCode: 450105
subject: Aboriginal and Torres Strait Islander curatorial, archives and museum studies
classificationCode: 450107
subject: Aboriginal and Torres Strait Islander history

description: Jacinta is a Jaru Yawuru women with Irish and English heritage and proud mother to three young men. Jacinta’s PhD thesis is a living and breathing oral history documenting seven generations of her family’s Aboriginal bloodline and centering the life of her great-grandmother Mabel Ita Eatts, (née Frederick), a Jaru woman and a Stolen Generations survivor born in 1907. This thesis intentionally echoes the voices of many First Nations families who have and continue to look deeply into living memory, Country, the archives, and the scholarship of others, to remember their ancestral lineage and love for themselves. Jacinta advocates for First Nations family standpoints inside of the Academy, their access to all the archives that relate to them, and intergeneration heart-felt, truth-telling, reconciliation, and healing through life story research and writing.
title: Wernicke`s Encephalopathy: What does the radiologist need to know?
Creators: name: Oliveira, Letícia
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: CNS
subject: Neuroradiology brain
subject: MR
subject: Education
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Demonstrate through clinical cases the various conditions that can lead to Wernicke`s Encephalopathy (WE), emphasizing radiologic patterns to assist the radiologists in the early diagnosis of the...
The actin regulators Enabled and Diaphanous direct distinct protrusive behaviors in different tissues during Drosophila development
Creators: name: Nowotarski, Stephanie H.
name: McKeon, Natalie
name: Peifer, Mark
name: Moser, Rachel J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Actin-based protrusions are important for signaling and migration during development and homeostasis. Gain- and loss-of-function and quantitative approaches are used to define differential roles for the actin elongation factors Diaphanous and Enabled in regulating distinct protrusive behaviors in different tissues during Drosophila morphogenesis.Actin-based protrusions are important for signaling and migration during development and homeostasis. Defining how different tissues in vivo craft diverse protrusive behaviors using the same genomic toolkit of actin regulators is a current challenge. The actin elongation factors Diaphanous and Enabled both promote barbed-end actin polymerization and can stimulate filopodia in cultured cells. However, redundancy in mammals and Diaphanous’ role in cytokinesis limited analysis of whether and how they regulate protrusions during development. We used two tissues driving Drosophila dorsal closure—migratory leading-edge (LE) and nonmigratory amnioserosal (AS) cells—as models to define how cells shape distinct protrusions during morphogenesis. We found that nonmigratory AS cells produce filopodia that are morphologically and dynamically distinct from those of LE cells. We hypothesized that differing Enabled and/or Diaphanous activity drives these differences. Combining gain- and loss-of-function with quantitative approaches revealed that Diaphanous and Enabled each regulate filopodial behavior in vivo and defined a quantitative “fingerprint”—the protrusive profile—which our data suggest is characteristic of each actin regulator. Our data suggest that LE protrusiveness is primarily Enabled driven, whereas Diaphanous plays the primary role in the AS, and reveal each has roles in dorsal closure, but its robustness ensures timely completion in their absence.
title: What's inside vagina: MRI imaging findings
Creators: name: Lagha, Mouadh
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system female
subject: MR
subject: Education
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The purpose of this review is to provide an illustrative summary of mri findings of vaginal tumors and its differential...
Food Marketing Review, 1986
Creators: name: Economic Research Service, USDA
name: Economic Research Service, USDA
Publisher: name: Unknown
Year: 1987
Subjects: subject: Food Consumption/Nutrition/Food Safety
subject: Industrial Organization
subject: Marketing
subject: FOS: Economics and business
subject: Food Service
subject: retailing
subject: manufacturing
subject: wholesaling
subject: marketing

description: U.S. food marketing sales likely will reach an estimated $555 billion in 1986, with food and beverage sales of $485 billion and $70 billion in nonfood sales, 5 percent over 1985. Food marketing will continue to be the largest U.S. marketing system, accounting for about one-tenth of both U.S. employment and gross national product (GNP). The food marketing system's contribution to GNP will be nearly nine times the value of the U.S. farm system's food-related contribution. Food manufacturers, retailers, and wholesalers will rank first in sales among all manufacturers, retailers, and wholesalers. This report analyzes these and other developments in the U.S. food marketing system.
(401571) John Bell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.