cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hyperchiria nausica
Creators: name: Bénéluz, Frédéric
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Saturniidae
Hyperchiria
Hyperchiria nausica

description: Hyperchiria nausica (Cramer, [1779]).
Phalaena Attacus nausica Cramer, 1779: 96, pl. 249, figs D, E.
Hyperchiria nausica – Michener 1952: 406.
DÉTERMINATION. — Morphologique.Moléculaire (BOLD:AAA3554).
LOCALITÉ TYPE. — Suriname (Lemaire 2002).
RÉPARTITION GÉOGRAPHIQUE. — Amérique centrale et presque toute l’Amérique méridionale subtropicale (Lemaire 2002).
DISTRIBUTION EN GUYANE. — Connu des trois zones biogéographiques.
HABITAT EN GUYANE. — Forêts primaire et secondaire.
MATÉRIEL DU MITARAKA EXAMINÉ. — Guyane • 1 ♂; Maripasoula, Mitaraka, Borne 1; alt. 670 m; 2°08’N, 54°25’W; 19-26.IX.2006, J.-P. Champenois leg.; Coll. BH (no. Hem 0037) • Spécimen barcodé EL2239 (BOLD: AAA3554); Maripasoula, Mitaraka, Crique Alama (DZ); alt. 310 m; 2°14’1.9”N, 54°27’38.1”W; La Planète revisitée, MNHN / PNI Guyane; APA-973-1; 23.II-26.III.2015; E. Poirier leg.; MNHN • 1 ♂; mêmes données que précédent; Coll. FB.
description: Published as part of Bénéluz, Frédéric, 2021, Liste commentée des Saturniidae (Lepidoptera, Bombycoidea) de Guyane, avec la liste des taxons récoltés au Mitaraka (extrême sud-ouest guyanais), pp. 759-809 in Zoosystema 43 (31) on page 784, DOI: 10.5252/zoosystema2021v43a31, http://zenodo.org/record/5796817
Novel Inhibitors of Rad51-DNA Repair in Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Surgery, radiation and chemotherapy are the most commonly used therapies for breast cancer. Both radiation and chemotherapy kill cells by damaging DNA, not only in tumor cells but also in normal cells, leading to unwanted side effects and toxicity. Moreover, breast tumor and other tumor cells contain elevated levels of DNA repair enzymes that repair the damage caused by radiation and chemotherapy, resulting in resistance to these treatments. Recent research from our laboratory and our collaborator, suggest that breast tumor tissues contain high levels of special DNA repair protein, called Rad51. We know much about how Rad51 works, because very similar proteins from bacteria (e.g., E. Coil RecA) have been well characterized. Rad51 is associated with a number of key breast cancer genes, including BRCA1, 2 and the tumor suppressor, p53. The activity of Rad51 is regulated by a direct protein:protein interactions with p53. In cases where p53 is absent or mutated, Rad51 has increased DNA repair activity. The net effect of increased Rad51 activity and reduced p53 function is to allow cancer cells to effectively repair DNA damage to neutralize radiation and chemotherapy treatments. Our hypothesis is that we can modulate Rad51 DNA repair by using synthetic peptide fragments of p53.

 Thus, we are developing Rad51 inhibitors that may serve to improve conventional breast cancer therapy by reducing the tumor resistance and, perhaps, resulting in novel therapeutics. The inhibitors are based on the peptide regions of p53 which bind to Rad51. Our methodology uses a special biosensor. This approach allows us to pass p53 peptides through a cell of the biosensor that contains Rad51 on its surface. Unbound peptides are removed and potentially active peptides that bind to Rad51 will be released further study. Promising Rad51-binding peptides will be analyzed by mass spectroscopy for their amino acid content and their structure will be inferred by molecular modeling. We propose to determine the smallest fragments or peptides of p53 protein that regulates the function of Rad51. Finally, these p53 peptides will be introduced into breast cancer cells and tested for their ability to neutralize the function of Rad51. We hope to demonstrate that p53 peptides can prevent the translocation Rad51 to the nucleus, and that the peptides enhance the effectiveness of chemotherapeutics and radiation for killing tumor cells

 It is becoming obvious that treating cancer effectively will involve an increased understanding of the underlying biology of resistance to current and future therapeutics. Our approach is novel, because we propose to inhibit the enzymes that repair the DNA damage sustained during radiation or chemotherapy.
Research Project Summary: Pinelands Biodiversity Study: Survey of Flora and Fauna in Managed vs. Unmanaged Forests in Two Pinelands Habitats
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection,Division of Science, Research and Technology
Year: 2008

description: Past land use and natural history in the New Jersey Pinelands have lead to the unique biodiversity of this  ecosystem. Forestry management practices both past and present have shaped preserved State lands, and the  specific effects of these practices with respect to changes in flora and fauna temporally have warranted investigation.  Surveys by Richard Stockton College of New Jersey were conducted in eight, 20-acre plots located at  four sites in Brendan T. Byrne State Forest and in Ocean County during the summer of 2007. Within each site,  two plots were examined: a study plot which had undergone recent forest management (e.g. thinning), and a  control plot which had not undergone any recent (e.g. at least 10 yrs.) forest management. Sites shown to be  the most highly diverse (i.e. highest biodiversity value) with respect to birds and plants were the Woodpecker  and Plantation sites (Shannon Indices of 3.01 and 2.92, respectively), where the theoretical maximum (H' max)  is 3.66. These sites have been managed such that habitat complexity has been retained (e.g. creation of open  areas with snags). Continual reintroduction of the early successional state through management and disturbance  has contributed to the high biodiversity in managed areas.
Ageniella (Priophanes) comes Banks 1946
Creators: name: Waichert, Cecilia
name: Colombo, Wesley Dondoni
name: Von Dohlen, Carol D.
name: Pitts, James P.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Ageniella
Ageniella comes

description: Ageniella (Priophanes) comes (Banks, 1946)
Priophanes comes BaNkS, 1946, MUS. COMp. ZOOL. BULL., vOL. 96, p. 447 [HOLOtypE: ♀, BRAZIL, Pará (MCZ #26160), ExaMINEd].
Distribution. BRaZIL.
Host. UNkNOWN.
Remarks. ThIS SpEcIES mORphOLOgIcaLLY RESEmbLES Eragenia micans (FabRIcIUS). IT caN bE REcOgNIZEd fROm E. micans aNd ThE OThER SpEcIES Of Ageniella bY ThE fOLLOWINg UNIQUE cOmbINaTION Of chaRacTERS: ThE INTEgUmENT IS bLack ON hEad aNd mETaSOma, ORaNgE ON mESOSOma; ThE aNTENNa aNd ThE LEgS aRE REddISh-bROWN; ThE cLYpEUS haS ThREE LObES, ThE apIcaL mEdIaN maRgIN haS SmaLL-ShaRpENEd TOOTh; ThE mETaSOma IS cOVEREd bY ShORT SILVER pUbEScENcE; ThE hEad haS ShORT SETaE, gOLdEN ON ThE TOp Of ThE hEad aNd SILVER bELLOW; ThE fRONT TIbIa IS SmOOTh; ThE mId TIbIa haS ShORT SpINES; ThE fORE TIbIa haS ScaLE-LIkE SpINES; ThE fORE aNd hINdWINgS aRE hYaLINE; ThE fOREWINg IS LONg aNd NaRROW, WITh ThREE VERY dISTINcTIVE baNdS; aNTERIORLY TO ThE daRkENEd apEx ThERE IS a WhITE baNd. ALThOUgh cOLORaTION RESEmbLES A. fabricii (BaNkS), ThE bRISTLY TIbIa, ThE ThREE-LObEd cLYpEUS aNd ThE WINgS aRE VERY dISTINcTIVE IN A. comes (BaNkS).
description: Published as part of Waichert, Cecilia, Colombo, Wesley Dondoni, Von Dohlen, Carol D. & Pitts, James P., 2018, Taxonomic contributions to Ageniella Banks, 1912 (Hymenoptera: Pompilidae) from Brazil, pp. 133-153 in Zootaxa 4403 (1) on page 147, DOI: 10.11646/zootaxa.4403.1.8, http://zenodo.org/record/1212065
Rhacocleis germanica
Creators: name: Skejo, Josip
name: Rebrina, Fran
name: Szövényi, Gergely
name: Puskás, Gellért
name: Tvrtković, Nikola
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Rhacocleis
Rhacocleis germanica

description: 66. Rhacocleis germanica (Herrich-Schäffer, 1840) = konjic grmušar
First faunistic record for Croatia: Frauenfeld 1861
Also reported as: Thamnotrizon pallidus Brunner von Wattenwyl, 1861 (Brunner von Wattenwyl in Frauenfeld 1861), R. discrepans Fieber, 1853 (Brunner von Wattenwyl 1861)
Distribution in Croatia: Widely distributed in the Mediterranean part and the Dinaric Alps, less common in the Pannonian region.
Distribution in Europe: From Southeastern France in the west to South Ukraine and Anatolia (Turkey) in the east, including Mediterranean islands such as Corsica, Crete and Corfu (Hochkirch et al. 2016).
description: Published as part of Skejo, Josip, Rebrina, Fran, Szövényi, Gergely, Puskás, Gellért & Tvrtković, Nikola, 2018, The first annotated checklist of Croatian crickets and grasshoppers (Orthoptera: Ensifera, Caelifera), pp. 1-95 in Zootaxa 4533 (1) on page 35, DOI: 10.11646/zootaxa.4533.1.1, http://zenodo.org/record/2615747
Hyperchiria aniris Jordan 1910
Creators: name: Bénéluz, Frédéric
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Saturniidae
Hyperchiria
Hyperchiria aniris

description: Hyperchiria aniris (Jordan, 1910).
Automeris aniris Jordan, 1910: 476, no. 11.
Hyperchiria aniris – Schüssler 1934: 376.
DÉTERMINATION. — Morphologique.Moléculaire (BOLD:AAD7579).
LOCALITÉ TYPE. — Guyana (Lemaire 1974).
RÉPARTITION GÉOGRAPHIQUE. — Guyane et Guyana (Lemaire 2002).
DISTRIBUTION EN GUYANE. — Connu des trois zones biogéographiques.
HABITAT EN GUYANE. — Préférentiellement, forêt primaire sur sable blanc.
MATÉRIEL DU MITARAKA EXAMINÉ. — Guyane • 1 ♂; Maripasoula, Mitaraka,Crique Alama (DZ); alt. 310 m; 2°14’1.9”N, 54°27’38.1”W; La Planète revisitée, MNHN / PNI Guyane; APA-973-1; 23.II-26. III.2015; E. Poirier leg.; Coll. FB.
description: Published as part of Bénéluz, Frédéric, 2021, Liste commentée des Saturniidae (Lepidoptera, Bombycoidea) de Guyane, avec la liste des taxons récoltés au Mitaraka (extrême sud-ouest guyanais), pp. 759-809 in Zoosystema 43 (31) on page 784, DOI: 10.5252/zoosystema2021v43a31, http://zenodo.org/record/5796817
Roeseliana roeselii
Creators: name: Skejo, Josip
name: Rebrina, Fran
name: Szövényi, Gergely
name: Puskás, Gellért
name: Tvrtković, Nikola
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Roeseliana
Roeseliana roeselii

description: 67. Roeseliana roeselii (Hagenbach, 1822) = Roeselov livadni konjic
First faunistic record for Croatia: Graber 1870
Also reported as: Platycleis brevipennis (Charpentier, 1825) (Graber 1870)
Distribution in Croatia: Common in the Pannonian part, Istria, Kvarner, and along the Dinaric Alps, not recorded in the largest part of the Adriatic coast (Dalmatia, Dubrovnik area) with adjacent islands.
Distribution in Europe: From Northern Spain, Northern Italy and Bulgaria in the south to the north of Sweden and Finland in the north, and Eastern European Russia in the east (Hochkirch et al. 2016).
description: Published as part of Skejo, Josip, Rebrina, Fran, Szövényi, Gergely, Puskás, Gellért & Tvrtković, Nikola, 2018, The first annotated checklist of Croatian crickets and grasshoppers (Orthoptera: Ensifera, Caelifera), pp. 1-95 in Zootaxa 4533 (1) on page 35, DOI: 10.11646/zootaxa.4533.1.1, http://zenodo.org/record/2615747
Macrophage plasticity in oral squamous cell carcinoma
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Oral squamous cell carcinoma (SCC) with jaw bone invasion has a high recurrence rate and poor prognosis. The suppressed immunity in the tumor environment represents the major hurdle for the success of the cancer treatment. During tumor bone invasion, macrophages are recruited as osteoclast precursors toward the tumor-bone interface. The influx of macrophages significantly changes the tumor microenvironment and potentially exacerbates immunosuppression. This proposal focuses on the immune modulation of macrophages during tumor bone invasion. A syngeneic murine model will be used to investigate the impact of macrophages on tumor immunity by SCC jaw bone invasion. In Aim 1, we will characterize the immune status altered by oral SCC bone invasion. The unique properties of macrophages associated with SCC bone invasion in supporting an immunosuppressive environment will be investigated. This will be achieved by examining the impact of tumor bone resorption on the function of macrophages and T cells, expressions of immune checkpoint molecules and cytokine profiles in local tumor and systemic host environments. In Aim 2, we will characterize the incidence of SCC-macrophage fusion during tumor bone invasion and investigate the clinical outcome of such phenomenon. Targeting macrophages has become an attractive approach for immunotherapy because they are essential for all aspects of tumor function and increasing evidence shows that they can be polarized to tumoricidal upon proper stimulation. Our goal is to understand the mechanisms of tumor bone invasion associated immunosuppression by macrophages and to develop highly effective immunotherapies against these tumors.
Research Project Summary: An Analysis of the Feasibility of Using Fertility Control to Manage New Jersey Black Bear Populations
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection, Division of Science, Research and Technology
Year: 2006

description: The contractor was directed to use all literature services available to document and evaluate all relevant research pertaining to the topic, and to provide an assessment of the: Biological feasibility (e.g., efficacy, health  & safety); Effectiveness for population control (probability of success in controlling freeranging bear populations) ; Economic practicality of using fertility control agents to control NJ's black bear population; and To provide conclusions on viable and nonviable techniques to control NJ's black bear population.
The New Jersey Atmospheric Deposition Network
Creators: name: No Name Supplied
Publisher: name: Division of Science, Research and Technology, New Jersey Department of Environmental Protection
Year: 2004

description: The New Jersey Atmospheric Deposition Network was collaborative environmental research and monitoring effort between Rutgers University and the New Jersey Department of Environmental Protection (NJDEP). The objectives of the project were to quantify current concentrations and deposition fluxes of atmospheric chemicals and assess their spatial and seasonal trends. The evaluation of the potential impact of atmospheric deposition to terrestrial aquatic ecosystems and the identification of local and regional sources of atmospheric contaminants were also implicit goals of the project. Ultimately NJADN results will establish baseline levels of atmospheric chemicals that will be useful in the evaluation of long-term trends and the effectiveness of pollution control efforts.
Recurrent GLI mutations in drug-resistant skin cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Basal cell carcinoma (BCC) are locally invasive skin cancers that affect over 4 million patients a year and are solely driven by activating mutations in the Hedgehog (HH) pathway. Inappropriate HH pathway activation also drives growth of a variety of cancers including brain, pancreatic, prostate, and small cell lung cancer that account for up to 25% of all human cancer deaths. The GLI1 and GLI2 transcription factors drive HH transcriptional output, with current therapies for advanced or metastatic BCCs limited to HH pathway antagonists that target proteins that lie upstream of the GLI transcription factors. Although effective, over 50% of advanced tumors display inherent drug resistance and 20% of tumors that do respond acquire drug resistance, indicating a critical need to understand the nature of drug resistance and to find the next generation of therapeutics. Towards this goal, we have found 110 mutations in GLI1 and GLI2 that may drive drug resistance by mining for recurrent mutations from our drug-resistant BCC patient tumor samples and cross referencing them to previously published tumor datasets across all sequenced cancers in the Catalogue of Somatic Mutations in Cancer (COSMIC) database. We have generated all 110 mutations and plan to stably express all variants in several HH responsive cell lines that include BCC lines ASZ001 and BSZ. We will characterize how each GLI mutation alters HH signaling, cell growth, and protein stability with a goal to identify specific clinically observed mutations that drive pathway activation. Positive hits that increase two out of the three criteria will be assayed for DNA binding, transcriptional activity, tumor growth, and drug resistance to understand how each mutation alters GLI function. So far, we have identified a cluster of mutations that disrupt interaction with the negative regulators PKA and SUFU, which significantly increases GLI activity levels. These results will provide insight on how GLI1 and GLI2 are regulated during HH pathway activation, how this regulation is altered during tumor growth and drug resistance, and will be invaluable in the discovery of future treatments for HH-dependent cancers.
Research Project Summary: New Jersey Atmospheric Deposition Network
Creators: name: No Name Supplied
Publisher: name: Division of Science, Research and Technology, New Jersey Department of Environmental Protection
Year: 2005

description: Atmospheric deposition is an important source of a number of contaminants to the environment. The New Jersey  Atmospheric Deposition Network (NJADN) was a collaborative research and monitoring effort between Rutgers  University and the New Jersey Department of Environmental Protection (NJDEP). The objectives of the project were to  quantify current concentrations and deposition fluxes of targeted contaminants and assess their spatial and seasonal  trends, and, to the extent possible, to determine the importance of atmospheric deposition relative to other inputs. Contaminants measured included PCBs, PAHs, certain organochlorine pesticides, heavy metals, nutrients, and  organic and elemental carbon particles. NJADN results have established baseline levels of the organic contaminants  in the gas, particle, and precipitation phases and of the metals, nutrients, and organic and elemental carbon in the  particle and precipitation phase. These baseline levels will be useful in the evaluation of long-term trends and  determining the effectiveness of pollution control efforts.
Hyperchiria carabobensis Brechlin & Meister 2010
Creators: name: Bénéluz, Frédéric
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Saturniidae
Hyperchiria
Hyperchiria carabobensis

description: Hyperchiria carabobensis Brechlin & Meister, 2010 *
Hyperchiria carabobensis Brechlin & Meister, 2010c: 26, fig. 1.
DÉTERMINATION. — Aucun exemplaire examiné. Données moléculaires d’exemplaires guyanais non disponibles.
LOCALITÉ TYPE. — Venezuela: Carabobo (Brechlin & Meister 2010c).
RÉPARTITION GÉOGRAPHIQUE. — Venezuela (Brechlin & Meister 2010c).
DISTRIBUTION EN GUYANE. — Littoral: Sinnamary, Station CIRAD de Paracou (R. Rougerie, com. pers.).
HABITAT EN GUYANE. — Méconnu.
description: Published as part of Bénéluz, Frédéric, 2021, Liste commentée des Saturniidae (Lepidoptera, Bombycoidea) de Guyane, avec la liste des taxons récoltés au Mitaraka (extrême sud-ouest guyanais), pp. 759-809 in Zoosystema 43 (31) on pages 784-785, DOI: 10.5252/zoosystema2021v43a31, http://zenodo.org/record/5796817
Ageniella (Priophanes) dolorosa Waichert & Colombo & Von Dohlen & Pitts 2018, comb. nov.
Creators: name: Waichert, Cecilia
name: Colombo, Wesley Dondoni
name: Von Dohlen, Carol D.
name: Pitts, James P.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Ageniella
Ageniella dolorosa

description: Ageniella (Priophanes) dolorosa (Banks, 1946), comb. nov.
Ameragenia dolorosa BaNkS, 1946, MUS. COMp. ZOOL. BULL., vOL. 96, p. 436 [HOLOtypE: ♀, ECUADOR, TENa (MCZ #26767), ExaMINEd].
Priophanes plagosa BaNkS, 1946, MUS. COMp. ZOOL. BULL., vOL. 96, p. 446 [HOLOtypE: ♀, BRAZIL, SaNta CatarINa (MCZ #26640), ExaMINEd], syn. nov.
Allageniella obsoleta HaUpt, 1959, NOva Acta LEOpOLdINa, vOL. (9)21, p. 23, 46 [HOLOtypE: ♀, BRAZIL, SaNta CatarINa (MLUH), NOt ExaMINEd]. SyNONyMIzEd by EvaNS (1973).
Distribution. ARgENTINa, BRaZIL, EcUadOR (BaNkS 1946; FERNÁNdEZ 2000).
Host. UNkNOWN.
Remarks. ThIS SpEcIES IS SImILaR mORphOLOgIcaLLY TO A. zeteki (BaNkS) aNd A. agitata (SmITh). Ageniella dolorosa dIffERS fROm A. zeteki bY haVINg faINTER cOLORaTION IN ThE fOREWINg, WhIch IS aLmOST hYaLINE, aNd ThE daRk maRkS IN ThE fOREWINg aRE faINTER aNd ShORTER. BESIdES, ThE facE dIffERS bY bEINg NaRROWER IN A. dolorosa, WITh ThE cLYpEUS TRapEZOIdaL aNd WITh ThE apIcaL maRgIN STRaIghT, WhILE A. zeteki haS ThE cLYpEUS ROUNdEd aNd pROjEcTEd aNTERIORLY. WE jUSTIfY SYNONYmIZINg A. dolorosa aNd A. plagosa (BaNkS) bY ThE ShaRINg chaRacTERISTIc: ThE INTEgUmENT IS bLack WITh faINT bLUISh-pURpLE REfLEcTIONS; ThE pUbEScENcE IS SILVER aNd ShORT; ThE fRONT TIbIa IS LONg aNd SmOOTh; ThE mId aNd hINd TIbIa haVE LONg aNd ThIN SpINES; ThE dORSaL facE Of ThE hINd TIbIa IS SpINOSE; ThE fOREWINg IS LONg, SUbhYaLINE WITh a faINT daRk baNd cOVERINg paRTIaLLY ThE cELLS R, 1M, aNd 1CU–2CU, ThE OThER baNd cOVERS ThE cELLS 2R 1,1RS–2RS, aNd 2M; VEIN M haS a SmaLL-faINT SpOT; aNd ThE apEx Of fOREWINg IS daRkENEd.
Ageniella agitata IS SImILaR mORphOLOgIcaLLY TO A. dolorosa aNd, pERhapS, ThE SENIOR SYNONYm Of ThE LaTER SpEcIES. WE abSTaIN fROm SYNONYmIZINg ThESE SpEcIES, bEcaUSE ThE hOLOTYpE haS ThE fORE LEg paLE bROWN IN cOLORaTION WITh ThE fEmUR bLack Up TO ThE apIcaL maRgIN, WhIch IS paLER; ThIS dIffERS fROm A. dolorosa WhO haS ThE fRONT LEg fULLY bLack. MOREOVER, A. dolorosa haS bLUE REfLEcTIONS ON ThE INTEgUmENT ThaT aRE LackINg IN A. agitata. PERhapS ThESE mORphOLOgIcaL dIffERENcES aRE gEOgRaphIcaL/ pOpULaTION VaRIaTION, bUT WE ONLY had accESS TO phOTOS Of A. agitata aNd ThINk IT IS pRUdENT NOT TO TakE NOmENcLaTURaL acTIONS IN ThIS caSE.
description: Published as part of Waichert, Cecilia, Colombo, Wesley Dondoni, Von Dohlen, Carol D. & Pitts, James P., 2018, Taxonomic contributions to Ageniella Banks, 1912 (Hymenoptera: Pompilidae) from Brazil, pp. 133-153 in Zootaxa 4403 (1) on page 147, DOI: 10.11646/zootaxa.4403.1.8, http://zenodo.org/record/1212065
Targeting the SUMOylation Pathway for Cancer Therapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The aim of the New Assistant Professor proposal is the use the latest methods in Structural Biochemistry to develop inhibitors targeting the SUMOylation cascade. Recent research has indicated that certain cancers have ‘onco-gene addiction’, where the tumor cell is heavily reliant on cellular pathways that are not essential to normal cells. One such pathway is the SUMOylation cascade, where studies by my collaborators and others have revealed that targeting this pathway would likely provide significant therapeutic benefit to currently difficult to treat cancers. Notably, this includes tumors driven by Kras, c-Myc or Notch-1 mutations, as well as the emergence of drug-resistance in acute myeloid leukemia. I propose to leverage the experimental expertise of my laboratory in structural biology and early-stage drug discovery methods, together with my specific knowledge and experience in the SUMOylation pathway, as evidenced by my peer-reviewed, published research. The SUMOylation cascade is a post-translational modification pathway utilized by the cell to add the small ubiquitin-like modifier (SUMO) onto a target protein. SUMO is added through the use of E1, E2 and E3 enzymes, and the pathway can be largely eliminated through inhibition of either the single E1 or single E2 enzyme of the cascade. Preliminary efforts from my laboratory to generate inhibitors include the development of protein crystals of both the E1 and E2 SUMO enzymes, which now enables rational-based drug discovery processes. Here, we will our employ fragment-based ligand discovery and computer aided drug discovery methods, aided by synchrotron-based x-ray crystallography, and our latest methods in x-ray diffuse scattering and small angle x-ray scattering. My laboratory will also leverage recent UC-based collaborations, which include the discovery a hit inhibitor compound from a high-throughput screen and the development of analogues of a natural product that can weakly inhibits the pathway; both of which can be analyzed for potential further development. The expected outcomes for this 1-year of research is the development of high affinity, selective hit compounds. Through further funding, I expect the development of these initial inhibitors into drug-like leads that have the potential of moving from the bench to the clinic.
Sepiana sepium
Creators: name: Skejo, Josip
name: Rebrina, Fran
name: Szövényi, Gergely
name: Puskás, Gellért
name: Tvrtković, Nikola
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Sepiana
Sepiana sepium

description: 68. Sepiana sepium (Yersin, 1854) = riđoglavi konjic
First faunistic record for Croatia: Frauenfeld 1861
Distribution in Croatia: Present in the Mediterranean part and the Dinaric Alps, with most records from the Adriatic coast and islands.
Distribution in Europe: Widespread in the Mediterranean from Southwestern France and Northeastern Spain to Southern Balkan Peninsula, all the way to Crimea in the east. Present on large Mediterranean islands such as Corsica, Sardinia, Sicily and Crete (Hochkirch et al. 2016).
description: Published as part of Skejo, Josip, Rebrina, Fran, Szövényi, Gergely, Puskás, Gellért & Tvrtković, Nikola, 2018, The first annotated checklist of Croatian crickets and grasshoppers (Orthoptera: Ensifera, Caelifera), pp. 1-95 in Zootaxa 4533 (1) on page 35, DOI: 10.11646/zootaxa.4533.1.1, http://zenodo.org/record/2615747
Kitchen Divas: Breast Cancer Risk Reduction for Black Women
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The California Breast Cancer Research Program (CBCRP), on the basis of its scientific peer review and the California Breast Cancer Research Council's programmatic review recommended the award of a research assistance grant to the Black Women for Wellness organization and the University of California, Los Angeles to further develop the Community Research Collaboration (CRC) application submitted for CBRP's funding cycle 11: "Kitchen Divas: Breast Cancer Risk Reduction for Black Women".

 The purpose of the award is to enable Ms. Robinson-flint and Dr. Ashing-Giwa to address scientific and collaborative issues raised during the scientific peer review of the above named CRC application.

 The work to be conducted during the course of this award is as follows:

 1. Strengthen scientific elements of the application. Specifically, at a minimum, these include:

 • Conduct a thorough literature review to justify the dietary intervention as relevant to breast cancer risk reduction.

 • Outline the process evaluation measures related to: recruitment and retention strategies; strengths and weakness of the intervention considering such factors as scheduling, duration, location; and strengths and weaknesses of the research team.

 • Develop a draft of the in-person post-study evaluation instrument. Testing the instrument on a small group of women receiving the cooking intervention is recommended.

 • Justify the education level of the materials prepared for participants, and adjust these as needed.

 • Prepare materials appropriated for an appendix describing the training of the kitchen divas, the actual educational messages to be delivered, and how the messages are delivered.

 2. Strengthen the collaborative elements of the proposed research collaboration. Specifically, at a minimum, these include:

 • Strengthen the functions of the proposed Community Advisory Board (CAB).

 • Bring additional nutritional intervention expertise to the collaboration.

 3. The results of the work conducted above is to be incorporated in a revised Concept Paper submitted to CBCRP by the deadline of 6:00 pm Thursday, November 3, 2005 and a revised CRC application based on the review comments of the Concept paper by the deadline of 6:00 pm Thursday, Feb. 23, 2006.
Altered self neuroblastoma epitopes for immunotherapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Immunotherapy harnessing a patient’s own T cell responses to selectively eliminate tumor cells is an emerging trend for the treatment of cancer. The therapy uses autologous T cells from the patient and subsequently activated in vitro, that are highly reactive to tumor neoantigens. These are peptides derived from mutated oncogene proteins and displayed on the cell surface, in tight association with the Major Histocompatibility Complex (MHC or HLA in humans). The chief barrier in developing personalized immunotherapy approaches is identifying suitable antigens displayed in a given patient, since minor changes in both the peptide and the HLA sequences can have drastic effects on the stability of the MHC assembly. Addressing the complexity of interactions will eventually allow us to evaluate the potential of a given patient as a candidate for immunotherapy, and to identify recurring targets towards engineering specific T cell responses. The UCSC Genome center has recently developed a tool, ProTECT, to predict therapeutically relevant peptide antigens from tumor sequencing data, and we have used it to predict “hotspot” neoantigens in neuroblastoma patients. In the research proposed here, we will characterize binding of the mutated peptides to the MHC in vitro, using mass spectroscopy, fluorescence polarization anisotropy and differential scanning fluorimetry. In addition, towards obtaining a detailed atomic picture of the interaction, we will elucidate the crystal structures of their respective MHCs. We will then use molecular modeling to investigate the extent to which changes in the HLA sequence can influence binding affinity. We will specifically evaluate mutations that result in a higher MHC stability relative to their parental self-epitope (termed “altered self” mutants), as ideal candidates for immunotherapy due to being less affected by immune tolerance mechanisms. Once we have identified such peptides, we will prepare MHC tetramer reagents for staining T cells from cancer patients, towards assessing the extent of specific responses to the neoantigen. The proposed research is significant because will provide new conceptual advances that directly link the molecular basis of neoantigen/MHC interactions with their immunogenicity. The pilot data obtained from this study will be used to seek additional, long-term funding from the NIH.
New Jersey Toxics Reduction Workplan, Study I-G Project Report
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection, Division of Science, Research, and Technology
Year: 2008

description: The New Jersey Toxics Reduction Workplan for NY-NJ Harbor (NJTRWP) includes a series of studies designed to provide the NJ Department of Environmental Protection (and other entities with environmental management and regulatory responsibilities) with the information needed to identify sources of the toxic chemicals of concern, and to prioritize these sources for appropriate action. Study I-G of the NJTRWP consists of the sampling of discharges from all twelve (12) New Jersey municipal wastewater treatment facilities (POTWs), and selected combined sewer outfalls (CSOs) and storm water outfalls (SWOs), which discharge to  NY-NJ Harbor. The primary objective of Study I-G is to estimate the loadings of the chemicals of concern  discharged from these POTWs and CSOs/SWOs into the NY-NJ Harbor estuary. Other uses of the data collected in Study I-G will be to (1) provide the necessary background information to initiate the trackdown efforts that will identify the ultimate sources of the chemicals of concern;  (2) provide the loadings data needed for developing and calibrating a water quality, sediment and contaminant fate and transport model; and (3) facilitate the development of Total Maximum Daily Load (TMDL) calculations.
Automerina cypria
Creators: name: Bénéluz, Frédéric
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Saturniidae
Automerina
Automerina cypria

description: Automerina cypria (Gmelin, 1790).
Phalaena cypria Gmelin, 1790: 2403, no. 1307.
Automerina (Automerina) cypria – Michener, 1952: 436.
Automerina cypria – Lemaire 2002: 342.
DÉTERMINATION. — Morphologique. Moléculaire (BOLD:AAC3033).
LOCALITÉ TYPE. — Exotica (Gmelin 1790).
RÉPARTITION GÉOGRAPHIQUE. — Guyano-amazonienne (Lemaire 2002).
DISTRIBUTION EN GUYANE. — Connu des trois zones biogéographiques.
HABITAT EN GUYANE. — Forêts primaire et secondaire, savane.
MATÉRIEL DU MITARAKA EXAMINÉ. — Guyane • 1 ♂; Maripasoula, Mitaraka, DZ Coulé-Coulé; 2°43’30”N, 54°47’30”W; 21.X.2004, J.-P. Champenois leg.; Coll. BH (no. 21555) • 1 ♂; Maripasoula, Mitaraka, Crique Alama (DZ); alt. 310 m; 2°14’1.9”N, 54°27’38.1”W; La Planète revisitée, MNHN / PNI Guyane; APA-973-1; 23.II-26. III.2015; E. Poirier leg.; MNHN • 1 ♂; mêmes données que précédent; Coll. FB • 1 ♂; Maripasoula, Mitaraka, Crique Alama (DZ); alt. 310 m; 2°14’1.9”N, 54°27’38.1”W; La Planète revisitée, MNHN / PNI Guyane; autorisation APA-973-2; 11-21.VIII.2015; FB leg.; MNHN.
description: Published as part of Bénéluz, Frédéric, 2021, Liste commentée des Saturniidae (Lepidoptera, Bombycoidea) de Guyane, avec la liste des taxons récoltés au Mitaraka (extrême sud-ouest guyanais), pp. 759-809 in Zoosystema 43 (31) on page 785, DOI: 10.5252/zoosystema2021v43a31, http://zenodo.org/record/5796817
Tessellana orina
Creators: name: Skejo, Josip
name: Rebrina, Fran
name: Szövényi, Gergely
name: Puskás, Gellért
name: Tvrtković, Nikola
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Tessellana
Tessellana orina

description: 69. Tessellana orina (Burr, 1899) = južni šikarski konjic
First faunistic record for Croatia: Brunner von Wattenwyl 1882
Also reported as: Platycleis nigrosignata Costa, 1863 (Brunner von Wattenwyl 1882)
Distribution in Croatia: Rare, in the eastern part of Dinaric Alps from Dinara Mt. (Rebrina et al. 2015) to Dubrovnik area: Ombla (Ramme 1951).
Distribution in Europe: Endemic to the Balkans—western part of the Balkan Peninsula from Croatia to the Peloponnesus (Hochkirch et al. 2016).
Distributional note: In Croatia it was recorded under the names (1) T. nigrosignata by Brunner von Wattenwyl (1882), Redtenbacher (1900), Kuthy (1908), Ramme (1951), and (2) T. orina by Kuthy (1908), Ramme (1951), Skejo & Rebrina (2013) and Rebrina et al. (2015). Italian endemic T. nigrosignata is not present in the Balkans (Massa & Fontana 2011), but replaced in the western part of the Balkan Peninsula by T. orina, while in the eastern by T. carinata (Berland & Chopard, 1922).
description: Published as part of Skejo, Josip, Rebrina, Fran, Szövényi, Gergely, Puskás, Gellért & Tvrtković, Nikola, 2018, The first annotated checklist of Croatian crickets and grasshoppers (Orthoptera: Ensifera, Caelifera), pp. 1-95 in Zootaxa 4533 (1) on page 35, DOI: 10.11646/zootaxa.4533.1.1, http://zenodo.org/record/2615747
Research Project Summary: Survey of Surface Source Waters for Giardia and Crytosporidium and Water Treatment Efficiency Evaluation
Creators: name: No Name Supplied
Publisher: name: Division of Science, Research and Technology, New Jersey Department of Environmental Protection
Year: 1995

description: Giardia and Cryptosporidium (shortened to "Crypto") parasites are among the leading identified causes of waterborne disease in the United States. Giardia cysts and Crypto oocysts have been identified in many surface waters throughout the country, but the concentrations in most of New Jersey's (NJ) surface waters, many of which are used as source waters for drinking water treatment plants, are unknown. To provide safe drinking water, treatment plants need to remove Giardia and Crypto from untreated water or reduce their concentrations to safe levels. Peak parasite levels, together with adverse water treatment factors, such as low water temperature, determine the maximum risk of human infection. However, parasite testing is not required by law and is not routinely performed by water treatment plants or regulatory personnel because the methods available are difficult, expensive, time-consuming, and have other drawbacks.
Tessellana tessellata
Creators: name: Skejo, Josip
name: Rebrina, Fran
name: Szövényi, Gergely
name: Puskás, Gellért
name: Tvrtković, Nikola
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Tessellana
Tessellana tessellata

description: 70. Tessellana tessellata (Charpentier, 1825) = prugastokrili šikarski konjic
First faunistic record for Croatia: Frauenfeld 1861
Distribution in Croatia: Along the Adriatic coast and the Dinaric Alps, with no records from Kvarner area and the Adriatic islands.
Distribution in Europe: Mediterranean part, from the Canary Islands in the west to Dalmatia in the east, reaching
Northern France in the north. Occurs also from Southern Ukraine to Eastern European Russia (Hochkirch et al. 2016).
description: Published as part of Skejo, Josip, Rebrina, Fran, Szövényi, Gergely, Puskás, Gellért & Tvrtković, Nikola, 2018, The first annotated checklist of Croatian crickets and grasshoppers (Orthoptera: Ensifera, Caelifera), pp. 1-95 in Zootaxa 4533 (1) on pages 35-36, DOI: 10.11646/zootaxa.4533.1.1, http://zenodo.org/record/2615747
Downregulation of XIST in Ovarian Cancer and Its Mechanisms
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This project aims to elucidate the functional role of cancer-associated long noncoding RNA (lncRNA), in particular, lncRNA XIST (X-inactive specific transcript) in ovarian cancer. Genome-wide association studies in cancer have revealed that more than 80% of cancer-associated genetic variations occur in noncoding sequences of the human genome. In parallel, an increasing number of cancer transcriptomes have also shown thousands of lncRNAs differentially expressed in a variety of human cancers when compared to normal cells. These indicate that understanding lncRNA-associated oncogenic pathways should be an important part of understanding the genetic mechanisms in cancer. The lncRNA XIST has recently been reported to affect cancer metastases and tumor progression. But whether the dysregulation of XIST can directly drive cancer symptoms, what are the XIST-mediated oncogenic pathways, and whether the lncRNA can be therapeutically targeted for cancer biomarkers are unclear. In addition, since XIST is known as the master regulator of X chromosome dosage compensation between XX female and XY male mammals, how XIST is regulated and whether differential expression of X-linked genes may affect female cancer in particular, are notable questions not fully addressed. Research in my lab has focused on the positive and negative regulators of XIST and, for the first time, reported detailed molecular mechanisms for the function of another lncRNA, Jpx, in activating Xist in mice. To investigate possible mechanisms of XIST regulation in cancer, we have used the cBioPortal for cancer genomics and observed significant downregulation of XIST correlated with higher neoplasm histological grades of ovarian cancer. We hypothesize that XIST, with its activator JPX, can function as tumor suppressors influencing oncogenic pathways related to proliferation and metastasis. We propose to identify the tumor growth relevant pathways in which XIST and JPX are associated within ovarian cancer. We also aim to define the genetic mechanisms underlying the loss of XIST in tumor cells. The outcomes will contribute to the functional annotation of cancer-associated lncRNA and impact future development of RNA biomarkers that may inform cancer diagnosis and treatment.
Automerina caudatula Felder 1874
Creators: name: Bénéluz, Frédéric
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Saturniidae
Automerina
Automerina caudatula

description: Automerina caudatula(C. Felder & R. Felder, 1874).
Hyperchiria caudatula C. Felder & R. Felder in C. Felder et al., 1874: pl. 91, fig. 1.
Automerina (Automerina) caudatula – Michener 1949: 146.
Automerina caudatula – Lemaire 2002: 346.
DÉTERMINATION. — Morphologique. Moléculaire (BOLD:AAB8067, AAB8068).
LOCALITÉ TYPE. — Amazonie (C. Felder et al. 1874).
RÉPARTITION GÉOGRAPHIQUE. — Guyano-amazonienne (Lemaire 2002).
DISTRIBUTION EN GUYANE. — Connu des trois zones biogéographiques.
HABITAT EN GUYANE. — Forêts primaire et secondaire.
MATÉRIEL DU MITARAKA EXAMINÉ. — Guyane • Spécimens barcodés EL2157 et EL2188 (BOLD:AAB8068); Maripasoula, Mitaraka, Crique Alama (DZ); alt. 310 m; 2°14’1.9”N, 54°27’38.1”W; La Planète revisitée, MNHN / PNI Guyane; APA-973-1; 23.II-26.III.2015; E. Poirier leg.; MNHN • 2 ♂; mêmes données que précédent; MNHN • 3 ♂; mêmes données que précédent; Coll. FB.
description: Published as part of Bénéluz, Frédéric, 2021, Liste commentée des Saturniidae (Lepidoptera, Bombycoidea) de Guyane, avec la liste des taxons récoltés au Mitaraka (extrême sud-ouest guyanais), pp. 759-809 in Zoosystema 43 (31) on page 785, DOI: 10.5252/zoosystema2021v43a31, http://zenodo.org/record/5796817
Hillaire, N. Voyage en Disneyland.
Creators: name: Hillaire, Norbert
Publisher: name: Zenodo
Year: 1975

description: "Voyage en Disneyland" constitue le premier chapitre d’un projet d’ouvrage, finalement abandonné à l’initiative de l’auteur, qui était destiné aux éditions Robert Laffont. Ce projet visait à explorer l’extériorisation du cinéma hors de la salle obscure et son extension aux dimensions d’un paysage urbain réel, prenant la forme d’une quasi-ville. L’analyse se concentrait initialement sur EPCOT aux États-Unis, avant de s’élargir à Disneyland.
Research Project Summary: Susceptibility of Potable Water Distribution Systems to Negative Pressure Transients
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection,  Division of Science, Research & Technology : American Water
Year: 2006

description: The operating conditions of a drinking water distribution  system (the network of underground pipes through which  water is delivered from a drinking water treatment plant to  customers) are rarely at a steady state. Each day, due to  constantly changing demand, water pumps start up or  switch off and valves open and close, resulting in rapid  flow changes. Previous research has established that  pressure waves generated by these disturbances can  propagate throughout the distribution system. Investigating pressure transients improves understanding  of how a system will behave in response to a variety of  events such as power outages, routine pump shut downs,  valve operations, flushing, firefighting, main breaks and  other events that can create significant, rapid, temporary  drops in system pressure. This project built upon the work  done in previous projects (Kirmeyer et al. 2001; Karim et al. 2003; Friedman et al. 2004; Gullick et al. 2005). It addressed the gap that exists in understanding distribution  system characteristics that are conducive to the occurrence  of negative pressure transient events. These events were  documented in several water systems and mitigation  strategies were identified.
Tettigonia balcanica Chobanov & Lemonnier-Darcemont 2014
Creators: name: Skejo, Josip
name: Rebrina, Fran
name: Szövényi, Gergely
name: Puskás, Gellért
name: Tvrtković, Nikola
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Tettigonia
Tettigonia balcanica

description: 71. Tettigonia balcanica Chobanov & Lemonnier–Darcemont, 2014 = balkanski zeleni konjic
First faunistic record for Croatia: Chobanov et al. 2014
Distribution in Croatia: Dinaric Alps and mountains of Dalmatia, not well documented, being only recently described: currently known from Poštak Mt. (Chobanov et al. 2014) and Biokovo Mt. (Skejo & Ozimec 27.VII.2016).
Distribution Europe: Endemic to the Balkans—mountains of the Balkan Peninsula, from Southern Croatia, Bosnia and Herzegovina, and Serbia, to Western and Central Bulgaria, and Northwestern Greece (Chobanov et al. 2016).
description: Published as part of Skejo, Josip, Rebrina, Fran, Szövényi, Gergely, Puskás, Gellért & Tvrtković, Nikola, 2018, The first annotated checklist of Croatian crickets and grasshoppers (Orthoptera: Ensifera, Caelifera), pp. 1-95 in Zootaxa 4533 (1) on page 36, DOI: 10.11646/zootaxa.4533.1.1, http://zenodo.org/record/2615747
Susceptibility of Potable Water Distribution Systems to Negative Pressure Transients
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection,  Division of Science, Research & Technology : American Water
Year: 2005

description: The operating conditions of drinking water systems are rarely at a true steady state. All systems will at some time be started up, switched off, or undergo other rapid flow changes. Previous research has established that the pressure waves generated by these disturbances can propagate throughout the distribution system, creating low and negative pressures in several locations, and that the low or negative pressures created can provide an opportunity for intrusion of non-potable water. The occurrence of low and negative pressure transients (also called surges) may also contribute to pipe fatigue and eventual pipe failure if stress fluctuations of sufficient magnitude and frequency occur. Investigating pressure transients improves understanding of how a system may behave in response to a variety of events such as power outages, routine pump shut downs, valve operations, flushing, firefighting, main breaks and other events that can create significant rapid, temporary drops in system pressure.
Research Project Summary: Routine Monitoring of Toxics in New Jersey Fish: Third Year (2006) of Routine Monitoring Program
Creators: name: No Name Supplied
Publisher: name: Patrick Center for Environmental Research, Academy of Natural Sciences
Year: 2008

description: This New Jersey Department of Environmental Protection (NJDEP) monitoring program is the third year of a  five-year program that builds upon prior fish contamination research. The program, conducted by the NJDEP's  Division of Science, Research and Technology (DSRT), focuses on collection of fish species currently under  fish consumption advisories due to chemical contamination, and to assess the status and trends of these  contaminants in the state's aquatic systems. This year 3 program primarily examined the entire Raritan River  Region.