cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Visualization at the mouse neuromuscular junction of a submembrane structure in common with Torpedo postsynaptic membranes
Creators: name: Sealock, R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1982

description: To test for submembrane structures common to postsynaptic membranes of muscle and electric tissue, mouse sternomastoid muscles were fixed in the presence of tannic acid under conditions such that a heavy layer of densely staining material was built up on plasma membranes. In this section electron micrographs of such muscles, the hydrophobic portion of the bilayer and some membrane-associated structures appear in strong negative contrast. At the endplate, acetylcholine receptor-rich membrane regions appear as a broad (14-15-nm) image approximately bisected by the thin (approximately 2-nm) image of the bilayer. The extracellular half of the image arises from the receptor protein. The cytoplasmic half contains a distinct bar of contrasted material which is precisely co-extensive with the receptor image Quantitative and direct visual comparisons show that the image is almost indistinguishable from that obtained by a similar method applied to isolated postsynaptic membranes from electric tissue of Torpedo californica (Sealock, R. (1982) J. Cell Biol. 92:514-522). In the latter case, the bar probably arises from the 43,000-dalton protein, a major peripheral membrane protein component of the isolated membranes. The results thus suggest that the 43,000-dalton protein in muscle and electric tissue forms similar structures and, conversely, that the structure in the isolated membranes retains the essential features of its in situ state.
ВЛИЯНИЕ МЕТОДОВ «УСКОРЕННОГО СТАРЕНИЯ» НА СОХРАННОСТЬ ПОТРЕБИТЕЛЬСКИХ СВОЙСТВ БЕЗАЛКОГОЛЬНЫХ НАПИТКОВ С ЦЕЛЬЮ ПРОГНОЗИРОВАНИЯ СРОКОВ ГОДНОСТИ
Creators: name: КОВАЛЕВА ИРИНА ЛЬВОВНА
name: СОБОЛЕВА ОЛЬГА АЛЕКСАНДРОВНА
name: СЕВОСТЬЯНОВА ЕЛЕНА МИХАЙЛОВНА
Publisher: name: Пиво и напитки
Year: 2020
Subjects: БЕЗАЛКОГОЛЬНЫЙ НАПИТОК
ЕСТЕСТВЕННОЕ СТАРЕНИЕ
ОРГАНОЛЕПТИЧЕСКИЕ ПОКАЗАТЕЛИ
СРОК ГОДНОСТИ
ТЕМПЕРАТУРА
УСКОРЕННОЕ СТАРЕНИЕ
ФИЗИКО-ХИМИЧЕСКИЕ ПОКАЗАТЕЛИ
SOFT DRINK
NATURAL AGING
ORGANOLEPTIC INDICATORS
SHELF LIFE
TEMPERATURE
ACCELERATED AGING
PHYSICO-CHEMICAL INDICATORS

description: В настоящее время сроки годности безалкогольных напитков чаще всего составляют от 6 до 12 мес. В связи с этим возникает необходимость экспресс-оценки сроков годности. Единые показатели оценки изменения качества данных продуктов в течение срока годности отсутствуют. В настоящей публикации приведены результаты исследования метода «ускоренного старения» с целью прогнозирования сроков годности безалкогольных напитков. Метод заключается в чередовании нагрева, выдержки и охлаждения продукта в течение 30 сут. Исследованию подвергали образцы безалкогольных напитков на сахаре и подсластителях, газированные и негазированные в различных видах упаковки. Оценивали органолептические и физико-химические показатели, содержание подсластителей и органических кислот через 15 и 30 сут эксперимента. Также проверяли влияние на данные показатели ультрафиолетового излучения в процессе «ускоренного старения» опытных образцов. Полученные результаты сравнивали с контрольными образцами, хранящимися в стандартных условиях, а также с образцами с истекшим сроком годности (естественное старение). Было установлено, что вариант режима «ускоренного старения» в течение 30 сут оптимален. Органолептические и физико-химические показатели опытных образцов практически сопоставимы с аналогичными показателями образцов с истекшим сроком годности. Содержание подсластителей на 15 сут эксперимента сопоставимо с данными при естественном старении. Содержание органических кислот, за исключением аскорбиновой кислоты, в процессе ускоренного и естественного старения в безалкогольных напитках снижается незначительно. Исследования по подбору объективных показателей, отражающих изменение качества безалкогольных напитков в процессе хранения в течение срока годности, продолжаются.
Comparison of Two 3D-Printed Indirect Bonding (IDB) Tray Design Versions and Their Influence on the Transfer Accuracy
Creators: name: Glasenapp, Julius Von
name: Hofmann, Eva
name: Süpple, Julia
name: Jost-Brinkmann, Paul-Georg
name: Koch, Petra Julia
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: indirect bonding
subject: transfer accuracy
subject: transfer tray
subject: tray design
subject: CAD/CAM
subject: 3D printing
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objective: This study aims to investigate the transfer accuracy of two different design versions for 3D-printed indirect bonding (IDB) trays. Materials and Methods: Digital plaster models of 27 patients virtually received vestibular attachments on every tooth using OnyxCeph³™ (Image Instruments, Chemnitz, Germany). Based on these simulated bracket and tube positions, two versions of transfer trays were designed for each dental arch and patient, which differed in the mechanism of bracket retention: Variant one (V1) had arm-like structures protruding from the tray base and reaching into the horizontal and vertical bracket slots, and variant two (V2) had a pocket-shaped design enclosing the brackets from three sides. Both tray designs were 3D-printed with the same digital light processing (DLP) printer using a flexible resin-based material (IMPRIMO® LC IBT/Asiga MAX™, SCHEU-DENTAL, Iserlohn, Germany). Brackets and tubes (discovery® smart/pearl, Ortho-Cast M-Series, Dentaurum, Ispringen, Germany) were inserted into the respective retention mechanism of the trays and IDB was performed on corresponding plaster models. An intraoral scan (TRIOS® 3W, 3Shape, Copenhagen, Denmark) was performed to capture the actual attachment positions and compared to the virtually planned positions with Geomagic© Control (3D Systems Inc., Rock Hill, SC, USA) using a scripted calculation tool, which superimposed the respective tooth surfaces. The resulting attachment deviations were determined in three linear (mesiodistal, vertical and orovestibular) and three angular (torque, rotation and tip) directions and analyzed with a descriptive statistical analysis. A comparison between the two IDB tray designs was conducted using a mixed model analysis (IBM, SPSS® Statistics 27, Armonk, NY, USA). Results: Both design versions of the 3D-printed IDB trays did not differ significantly in their transfer accuracy (p > 0.05). In total, 98% (V1) and 98.5% (V2) of the linear deviations were within the clinically acceptable range of ± 0.2 mm. For the angular deviations, 84.9% (V1) and 86.8% (V2) were within the range of ± 1 degrees. With V1, most deviations occurred in the mesiodistal direction (3.3%) and in rotation (18%). With V2, most deviations occurred in the vertical direction (3.8%) and in palatinal and lingual crown torque (16.3%). Conclusions: The transfer accuracies of the investigated design versions for 3D-printed IDB trays show good and comparable results albeit their different retention mechanisms for the attachments and are, therefore, both suitable for clinical practice.
Second addendum to the Leafhoppers and Planthoppers of Germany (Hemiptera: Auchenorrhyncha)
Creators: name: Nickel, Herbert
Publisher: name: Cicadina
Year: 2022
Subjects: subject: 000

description: This paper presents new faunistic and ecological data on 21 species of planthoppers and leafhoppers in Germany. Delphax armeniacus An., Javesella bottnica Huld., Micantulina teucrii (Cer.), Ficocyba ficaria (Horv.), Placotettix taeniatifrons (Kbm.), Allygidius furcatus (Ferr.), Phlogotettix cyclops (M. & R.) and Thamnotettix exemtus Mel. are new to the country. New distributional and ecological data are given for Megamelodes lequesnei W. Wg., Cercopis arcuata Fieb., Macropsis mulsanti (Fieb.), Dryodurgades antoniae (Mel.), Hishimonus hamatus Kuoh, Maiestas horvathi (Then), Anoplotettix fuscovenosus (Ferr.), Cicadula placida (Horv.), Ederranus discolor (J. Shlb.), Paralimnus lugens (Horv.), Psammotettix albomarginatus W. Wg., Pinumius areatus (St.l) and Cosmotettix evanescens Oss. An analysis of 28 species recorded as new for Germany in the last two decades showed that the increase is caused in equal shares by better taxonomic and faunistic knowledge on the one hand and real ecological changes through anthropogenic introductions and northward range expansions (presumably driven by climatic factors) on the other hand.
An alternative in vitro model considering cell-cell interactions in fiber-induced pulmonary fibrosis
Creators: name: Pantzke, Jana
name: Offer, Svenja
name: Zimmermann, Elias J.
name: Kuhn, Evelyn
name: Streibel, Thorsten
name: Oeder, Sebastian
name: Di Bucchianico, Sebastiano
name: Zimmermann, Ralf
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Particularly since the wide-ranging health effects of asbestos exposure became known, great emphasis has been placed on detailed toxicity testing of known but also newly developed fiber materials. Exposure to respirable pollutants like fibers can lead to tissue injury causing lung diseases such as pulmonary fibrosis or cancer. In order to detect the toxic potential of such aerosols at an early stage, the development of suitable test systems is essential. In this study, we illustrate the development of an advanced in vitro cell model closely resembling the physiological structure of the alveoli, and we highlight its advantages over simpler models to predict pro-fibrotic changes. For this reason, we analyzed the cytotoxic effects of fiber-like multi-walled carbon nanotubes after 24 and 48 h exposure, and we investigated inflammatory, genotoxic and pro-fibrotic changes occurring in the developed triple culture consisting of lung epithelial cells, macrophages and fibroblasts compared to a co-culture of epithelial cells and fibroblasts or a mono culture of epithelial cells. In summary, the triple culture system is more precisely able to detect a pro-fibrotic phenotype including epithelial-mesenchymal transition as well as secondary genotoxicity, even if exhibiting lower cytotoxicity in contrast to the less advanced systems. These effects might be traced back to the complex interplay between the different cell types, all of which play an important role in the inflammatory response, which precedes wound healing, or even fibrosis or cancer development.
A model for large non-standard interactions of neutrinos leading to the LMA-Dark solution
Creators: name: Farzan, Yasaman
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: It is well-known that in addition to the standard LMA solution to solar anomaly, there is another solution called LMA-Dark which requires Non-Standard Interactions (NSI) with effective couplings as large as the Fermi coupling. Although this solution satisfies all the bounds from various neutrino oscillation observations and even provides a better fit to low energy solar neutrino spectrum, it is not as popular as the LMA solution mainly because no model compatible with the existing bounds has been so far constructed to give rise to this solution. We introduce a model that provides a foundation for such large NSI with strength and flavor structure required for the LMA-Dark solution. This model is based on a new $U(1)^\prime$ gauge interaction with a gauge boson of mass $\sim 10$ MeV under which quarks as well as the second and third generations of leptons are charged. We show that observable effects can appear in the spectrum of supernova and high energy cosmic neutrinos. Our model predicts a new contribution to the muon magnetic dipole moment and new rare meson decay modes.
description: 10 page; References and more phenomenological bounds added; Results unchanged
Preferential immunohistochemical localization of vasoactive intestinal polypeptide (VIP) in the sacral spinal cord of the cat: light and electron microscopic observations
Creators: name: Rethelyi, M.
name: Petrusz, P.
name: Honda, C. N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1983

description: In the present study we have employed immunoperoxidase techniques to investigate the distribution of vasoactive intestinal polypeptide (VIP)- like immunoreactivity in the spinal cord and sensory ganglia of the cat. The spinal distribution of VIP-containing neuronal processes was also compared with that of substance P (SP), somatostatin (SOM), and cholecystokinin-8 (CCK) at lumbar, sacral, and coccygeal levels. At sacral levels, VIP was found to be contained in small and medium-sized primary sensory neurons and in dorsal rootlets. Deafferentation, by either ganglionectomy or dorsal rhizotomy, resulted in a nearly complete loss of VIP immunoreactivity in the spinal cord. The spinal distribution of VIP fibers and terminals was most dense and extensive in sacral segments. Forming a thin shell around the dorsal horn, collaterals, apparently originating from Lissauer's tract, projected either medially or laterally through lamina I. Laterally, many VIP axons terminated in lateral laminae V to VII. Others projected further through the neck of the dorsal horn to medial lamina V and the gray matter near the central canal. Medially, VIP axons descended through lamina I to expand into terminal fields in the posterior commissure and medial lamina V. At the ultrastructural level, VIP-like immunoreactivity was found in dense core vesicles within axonal enlargements containing both large dense core and smaller clear round vesicles. Synaptic connections were infrequently observed but, when encountered, were of the simple axodendritic type. The spinal distribution of VIP-containing fibers was remarkably similar to that reported for pelvic nerve visceral afferents, both in termination patterns within the spinal gray matter and in localization to the sacral cord. The density of SP-, SOM-, and CCK-containing fibers and terminals was constant at all levels examined (L4 to Co4). In marked contrast, the distribution of VIP fibers, much like that of pelvic nerve afferents, was mostly confined to sacral segments. Thus, although SP, SOM, and CCK may be contained within a population of sacral visceral afferents, they must be common to afferent systems in other segments as well. VIP, however, appears to be preferentially contained within pelvic visceral afferent fibers confined mostly to sacral segments.
(1440) Constance Wishart Ingham
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Suppl. File 2 from Within-population variability in a moth sex pheromone blend, part 2: selection towards fixation.
Creators: name: Groot, Astrid T.
name: Wijk, Michiel Van
name: Villacis-Perez, Ernesto
name: Kuperus, Peter
name: Schöfl, Gerhard
name: Veldhuizen, Dennis Van
name: Heckel, David G.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Gels showing the screens of the stop codon
Analysis of the apparent biphasic axonal transport kinetics of fucosylated glycoproteins
Creators: name: Goodrum, J. F.
name: Morell, P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1984

description: Following intraocular injection of [3H]fucose, which labels many glycoproteins of retinal ganglion cells, the accumulation of transported radioactivity arriving at the superior colliculus (nerve terminals) peaks within a few hours and decays with a time course of hours. Then, over a period of several days, radioactivity again accumulates at the superior colliculus and then decays with a half-life of days. The second peak also represents fast transported material since it occurs almost simultaneously along the optic nerve and tract as well as at the nerve endings. Such data have been interpreted as evidence for both a group of rapidly released, rapidly transported glycoproteins (first peak) and a group of slowly released but rapidly transported glycoproteins (second peak). We investigated this supposition by studying in more detail the metabolism of some individual fucosylated proteins in both the retina and superior colliculus. We noted that much of the radioactivity incorporated in fucosylated glycoproteins at the retina was rapidly metabolized (with a turnover on the order of hours), while the remainder of the fucosylated moieties had a metabolic half-life on the order of days. This was also true of the metabolic behavior of several individual glycoproteins, selected for study because they are major components of the group committed to transport and accumulating in two waves at the superior colliculus. In other experiments we injected [35S]methionine intraocularly and examined the metabolism in the retina and the kinetics of transport to the superior colliculus of the peptide backbone of these same individual proteins. In contrast to the two waves of accumulation of radioactivity from [3H]fucose, accumulation of radioactivity of the peptide backbone of the same glycoproteins was monophasic. Our explanation of these data involves the presence of two types of fucose moieties on the peptides. One group of fucose moieties is labile and is lost from the peptide backbone over a period of hours. Other fucose moieties are approximately as metabolically stable as the peptide backbones to which they are attached. The actual peptide backbones of the glycoproteins are committed to rapid transport over a period of several days. Thus, the first (and most prominent) peak of transported radioactivity in [3H]fucosylated glycoproteins does not represent a discrete phase of transport but, rather, is the summation of kinetics of gradual arrival of proteins and the rapid drop in their specific radioactivity as the more labile moieties of [3H]fucose are lost.( TRUNCATED AT 400 WORDS)
Equivariance and invariance for optimal designs in generalized linear models exemplified by a class of gamma models
Creators: name: Idais, Osama
name: Schwabe, Rainer
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: Optimal design
subject: Invariance
subject: Equivariance
subject: Maximin efficiency
subject: Generalized linear model
subject: 510.72

description: The main intention of the present work is to outline the concept of equivariance and invariance in the design of experiments for generalized linear models and to demonstrate its usefulness. In contrast with linear models, pairs of transformations have to be employed for generalized linear models. These transformations act simultaneously on the experimental settings and on the location parameters in the linear component. Then, the concept of equivariance provides a tool to transfer locally optimal designs from one experimental region to another when the nominal values of the parameters are changed accordingly. The stronger concept of invariance requires a whole group of equivariant transformations. It can be used to characterize optimal designs which reflect the symmetries resulting from the group actions. The general concepts are illustrated by models with gamma distributed response and a canonical link. There, for a given transformation of the experimental settings, the transformation of the parameters is not unique and may be chosen to be nonlinear in order to fully exploit the model structure. In this case, we can derive invariant maximin efficient designs for the Dand the IMSE-criterion.
Suppl Material 291118 from Within-population variability in a moth sex pheromone blend, part 2: selection towards fixation.
Creators: name: Groot, Astrid T.
name: Wijk, Michiel Van
name: Villacis-Perez, Ernesto
name: Kuperus, Peter
name: Schöfl, Gerhard
name: Veldhuizen, Dennis Van
name: Heckel, David G.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Supplementary information, including 5 tables and 8 figures
Aromatic sulphonamides of aziridine-2-carboxylic acid derivatives as novel PDIA1 and PDIA3 inhibitors
Creators: name: Zelencova-Gopejenko, D.
name: Andrianov, V.
name: Domracheva, I.
name: Kanepe-Lapsa, I.
name: Milczarek, M.
name: Stojak, M.
name: Przyborowski, K.
name: Fedak, F. A.
name: Walczak, M.
name: Kramkowski, K.
name: Wietrzyk, J.
name: Chlopicki, S.
name: Kalvins, I.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: In this study, we report a series of newly synthesised sulphonamides of aziridine-2-carboxylic acid (Az-COOH) ester and amide analogues as potent protein disulphide isomerase (PDI, EC 5.3.4.1) inhibitors. The inhibitory activity on PDI was determined against recombinant human PDIA1 and PDIA3 proteins using an insulin reduction assay. These compounds in low micromolar to low nanomolar concentrations showed the effective in vitro inhibitory properties of PDIA1 with weaker effects on PDIA3. Complexes of 15N- and 15N,13C- uniformly labelled recombinant human PDIA1a with two PDIA1 inhibitors were produced and investigated by a protein nuclear magnetic resonance (NMR) spectroscopy. It was found that both C53 and C56 of the PDIA1 enzyme were involved in covalent binding. Finally, in a range of pharmacological studies, we demonstrated that investigated compounds displayed anti-cancer and anti-thrombotic activity. These findings demonstrate that sulphonamides of Az-COOH derivatives are promising candidates for the development of novel anti-cancer and anti-thrombotic agents.
Subjective and objective demands on different types of differential stress inventory
Creators: name: Karlsen, Håvard R.
name: Böckelmann, Irina
name: Thielmann, Beatrice
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: Burnout
subject: Heart rate variability
subject: Stress
subject: Maslach burnout inventory
subject: Differential stress inventory
subject: 610.72

description: Purpose To validate the differential stress inventory (DSI) by evaluating the objective and subjective stress differences in the five DSI types in the occupational setting. Methods A total of 119 German participants working as medical assistants (n = 40) or in a bank (n = 79) were recruited. They completed the Maslach Burnout Inventory–General Survey, the DSI, and wore ECG measuring devices for 24 h to measure heart rate variability. The DSI was used to group people into one of five types according to how they perceived and coped with stress: normal, overstressed, stress-resistant, low stress/high coping, or high stress/high coping. Results The overstressed type had significantly more burnout symptoms than the other types. The high stress/high coping type also had more symptoms of emotional exhaustion and total burnout compared to the other types, while the low stress/ high coping and the stress-resistant types generally had the lowest levels of burnout. There were no differences on the HRV parameters among the DSI types. Conclusion Categorising people into types like in the DSI can help make workers aware of unhealthy stress and coping patterns before they turn into more severe pathology. Proper application and targeted preventive measures can save the individual’s health and the company’s budget. While the DSI picked up on differences in burnout symptoms as a long-term consequence of stress, there is evidence that it cannot pick up on short-term stress or physical stress as measured by HRV from the 24 h recording.
Combination of immunocytochemistry and radioligand receptor assay to identify beta-adrenergic receptor subtypes on astroglia in vitro
Creators: name: Evans, Tony
name: Harden, T. Kendall
name: Trimmer, Patricia A.
name: Smith, Mchardy M.
name: Mccarthy, Ken D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1984

description: There is an increasing need to assess the distribution of receptors for neuroactive substances on specific neural cell types. This study describes the establishment of methodology that combines the quantification of beta-adrenergic receptor subtypes by radioligand binding assays with immunocytochemical analysis of the contribution of astroglia (identified by the presence of glial fibrillary acidic protein) and fibroblasts (identified by the presence of fibronectin) to cultures prepared from neonatal rat cerebral cortex. The effects of subtle changes in culture methodology on the cellular composition of cerebral cortical cultures and the distribution of beta-adrenergic receptor subtypes were examined. The data indicate that (1) a decrease in the density of the initial plating suspension, (2) an increase in the age of the animals, or (3) supplementation of the cortical cell suspension with meningeal fibroblasts all result in an increase in fibronectin staining and a decrease in glial fibrillary acidic protein antibody staining. This change in the cellular composition of the cortical cultures correlated with an increase in the number of beta 2- adrenergic receptors and a corresponding decrease in the number of beta 1-adrenergic receptors. These observations point out the care which must be exercised when preparing primary astroglial cultures of sufficient purity for large-scale biochemical and pharmacological studies.
Spitzer bright, UltraVISTA faint sources in COSMOS: the contribution to the overall population of massive galaxies at z=3-7
Creators: name: Caputi, K. I.
name: Ilbert, O.
name: Laigle, C.
name: McCracken, H. J.
name: Fevre, O. Le
name: Fynbo, J.
name: Milvang-Jensen, B.
name: Capak, P.
name: Salvato, M.
name: Taniguchi, Y.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We have analysed a sample of 574 Spitzer 4.5 micron-selected galaxies with [4.5]<23 and Ks_auto>24 (AB) over the UltraVISTA ultra-deep COSMOS field. Our aim is to investigate whether these mid-IR bright, near-IR faint sources contribute significantly to the overall population of massive galaxies at redshifts z>=3. By performing a spectral energy distribution (SED) analysis using up to 30 photometric bands, we have determined that the redshift distribution of our sample peaks at redshifts z~2.5-3.0, and ~32% of the galaxies lie at z>=3. We have studied the contribution of these sources to the galaxy stellar mass function (GSMF) at high redshifts. We found that the [4.5]<23, Ks_auto>24 galaxies produce a negligible change to the GSMF previously determined for Ks_auto<24 sources at 3=~50% of the galaxies with stellar masses Mst>~6 x 10^10 Msun. We also constrained the GSMF at the highest-mass end (Mst>~2 x 10^11 Msun) at z>=5. From their presence at 5=
description: 18 pages, 15 figures, 4 tables. Updated to match version in press at the ApJ
Effect of 4DryField® PH on blood loss in hip bipolar hemiarthroplasty following intracapsular femoral neck fracture : a randomized clinical trial
Creators: name: Lucas, Benjamin
name: Riebau, Christian
name: Mohr, Juliane
name: Pliske, Gerald
name: Walcher, Felix
name: Piatek, Stefan
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: 4DryField® PH
subject: Blood loss
subject: Femoral neck fractures
subject: Hip arthroplasty
subject: 610.72

description: Background: One of the most common complications of hip arthroplasty is excessive blood loss that could necessitate allogenic blood transfusion, which is further associated with other complications, such as infections, transfusion reactions or immunomodulation. In gynecology, 4DryField®PH, an absorbable polysaccharide-based formulation, is used for hemostasis and adhesion prophylaxis. In this study, we evaluated its hemostatic effect in patients undergoing hip bipolar hemiarthroplasty following intracapsular femoral neck fracture. Methods: We studied 40 patients with intracapsular femoral neck fractures (Garden III or IV) admitted at our institution between July 2016 and November 2017. We included patients above 60 years with simple fracture and without pathologic fractures. Patients were randomized into intervention and control groups. The intervention group received 5 g of 4DryField® PH (subfascially and subcutaneously) during wound closure. Three drainages were inserted in a standardized manner (submuscular, subfascial, and subcutaneous) and drainage volume was measured immediately before extraction. Total blood loss was calculated using Mercuriali’s formula and standard hemograms upon admission and five days after surgery. Volume of postoperative hematoma was measured using point-of-care ultrasound seven days after surgery. Results: Volume of the postoperative hematoma was reduced by 43.0 mL. However, significant reduction of total blood loss and drainage volume was not observed. Conclusions: We observed that 4DryField® PH had a local hemostatic effect, thereby reducing volume of the postoperative hematoma. However, this reduction was small and had no effect on the total blood loss. Further studies are warranted to improve the application algorithm.
Soil microbial communities shift along an urban gradient in Berlin, Germany
Creators: name: Whitehead, James
name: Roy, Julien
name: Hempel, Stefan
name: Rillig, Matthias C.
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: urban soil
subject: fungi
subject: Glomeromycota
subject: bacteria
subject: urban ecology
subject: Berlin
subject: Cercozoa
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: The microbial communities inhabiting urban soils determine the functioning of these soils, in regards to their ability to cycle nutrients and support plant communities. In an increasingly urbanized world these properties are of the utmost importance, and the microbial communities responsible are worthy of exploration. We used 53 grassland sites spread across Berlin to describe and explain the impacts of urbanity and other environmental parameters upon the diversity and community composition of four microbial groups. These groups were (i) the Fungi, with a separate dataset for (ii) the Glomeromycota, (iii) the Bacteria, and (iv) the protist phylum Cercozoa. We found that urbanity had distinct impacts on fungal richness, which tended to increase. Geographic distance between sites and soil chemistry, in addition to urbanity, drove microbial community composition, with site connectivity being important for Glomeromycotan communities, potentially due to plant host communities. Our findings suggest that many microbial species are well adapted to urban soils, as supported by an increase in diversity being a far more common result of urbanity than the reverse. However, we also found distinctly separate distributions of operational taxonomic unit (OTU)s from the same species, shedding doubt of the reliability of indicator species, and the use of taxonomy to draw conclusion on functionality. Our observational study employed an extensive set of sites across an urbanity gradient, in the region of the German capital, to produce a rich microbial dataset; as such it can serve as a blueprint for other such investigations.
(1435) Annie Seaton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Zur Sedimentologie der oberoligozänen Seesedimente von Enspel/Westerwald: On the sedimentology of Late Oligocene lake sediments from Enspel/Westerwald
Creators: name: Gaupp, Reinhard
name: Wilke, Andreas
Publisher: name: Hallesches Jahrbuch für Geowissenschaften
Year: 1998
Subjects: subject: 000

description: Vulkanoklastisch geprägte lakustrine Ablagerungen des oberoligozänen Enspel-Sees wurden anhand von Bohrkernen aus drei Kurzbohrungen sowie an Oberflächenproben sedimentologisch und petrographisch untersucht. In dem bearbeiteten ca. 24 m mächtigen Abschnitt der Seesedimente sind Ablagerungsbedingungen eines tiefen, mesotrophen bis eutrophen Sees dokumentiert. Unter meromiktischen Stillwasser-Verhältnissen mit geringer allochthoner Sedimentzufuhr kam es zur Hintergrund-Sedimentation von Schwarzpeliten, die volumenmäßig stark zurücktreten gegenüber den gröberklastischen Ereignissedimenten. Die Anlieferung klastischen Materials erfolgte vorrangig punktuell durch Kleindeltas. Eine eindeutige Richtung ist nicht rekonstruierbar. Außerdem trugen pyroklastische Ereignisse zur Unterbrechung der tieflakustrinen meromiktischen Stillwasser-Sedimentation bei. Instabile Zwischenlagerung auf steileren(?) Reliefgradienten am Beckenhang führte zu episodischer Resedimentation, die zusammen mit fluviatil-deltaischen Schüttungsereignissen für kurzzeitige und zumindest teilweise Durchmischungen des Wasserkörpers sorgten. Saisonale Laminite (Warven) und faziell eigenständige Sedimente flacher Litoralzonen konnten bislang nicht belegt werden.
description: Lacustrine, partly volcanoclastic deposits of Late Oligocene Lake Enspel (Rhenish Massif, Westerwald, Germany) were investigated with sedimentologic and petrographic techniques, us ing cores and surface samples. The stratigraphic section of 24 m length indicates sediments of a small, deep, mesotrophic to eutrophic lake. Background still-water sedimentation under meromiktic conditions with low rates of sediment supply resulted in minor amounts of black shale, which are subordinate to coarse clastic event deposits. Supply of coarse clastic material mainly occurred through small deltaic entry points. Preferred directions of sediment supply can not be detected yet. Both pyroclastic deposition and gravitational redeposition from steep marginal slopes of the lake basin, episodically interrupted deep water lacustrine background sedimentation. Collapse of oversteepened slopes and fluvial -deltaic runoff events lead to at least partial and short term mixis of the lacustrine water body. Saisonal laminites (varves) and littoral shallow water deposits have not yet been observed.
Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors
Creators: name: Giovannuzzi, Simone
name: Bonardi, Alessandro
name: Gratteri, Paola
name: Nocentini, Alessio
name: Supuran, Claudiu T.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Considering the unrecognised physio-pathological role of human carbonic anhydrase III (hCA III), a structure-based drug design was set up to identify the first-in-class potent and selective inhibitors of this neglected isoform. hCA III targeting was planned considering a unique feature of its active site among the other hCA isoforms, i.e. the Leu198/Phe198 substitution which interferes with the binding of aromatic/heterocyclic sulfonamides and other inhibitors. Thus, new aliphatic primary sulfonamides possessing long and flexible (CH2)nSO2NH2 moieties were designed to coordinate the zinc(II) ion, bypassing the bulky Phe198 residue. They incorporate 1,2,3-triazole linkers which connect the tail moieties to the sulfonamide head, enhancing thus the contacts at the active site entrance. Some of these compounds act as nanomolar and selective inhibitors of hCA III over other isoforms. Docking/molecular dynamics simulations were used to investigate ligand/target interactions for these sulfonamides which might improve our understanding of the physio-pathological roles of hCA III.
Mikro-organofazielle Studien an Sedimenten des Enspel-Sees (Oberoligozän, Westerwald, Deutschland): Microscopic organic study of Lake Enspel sediments (Upper Oligocene, Westerwald area, Germany)
Creators: name: Clausing, Andreas
Publisher: name: Hallesches Jahrbuch für Geowissenschaften
Year: 1998
Subjects: subject: 000

description: Die Ablagerungen der oberoligozänen Fossillagerstätte Enspel enthalten reichlich organische Rückstände, welche die Primärproduktion des Sees widerspiegeln. Vertreter von verschiedenen Algengruppen belegen das autochthone Phytoplankton. Es sind dies Chrysophyceen, Diatomeen, eine Dinoflagellatenspezies und die Grünalgen Botryococcus und Tetraedron. Alginit B wird durch gegenwärtig noch nicht identifizierte Produzenten gebildet, die wahrscheinlich zu den Cyanobakterien zu rechnen sind. Daneben sind benthische Mikrobenmatten bekannt, die zum Teil ebenfalls als Alginit B erhalten sind. Dinoflagellatenzysten dominieren in einem Sediment das durch Alginit A gekennzeichnet wird. Chrysophyceenzysten und Diatomeenschalen bilden ebenfalls ausgeprägte laminare Lagen. Die ausgeprägte Lamination deutet auf jahreszeitlich gesteuerte Primärproduktion, sowie kurzzeitig erfolgende Produktionsmaxima von organischer Substanz hin. Zusätzlich erfolgten kurzfristige Ereignisse mit hohen Sedimentationsraten und schneller Eliminierung der aquatischen Flora. Ursachen waren vulkanische Aktivitäten und anschließende Erosion, die zu wenig laminierten Sedimenten führten.
description: The sediments of the Upper Oligocene Enspel lake are rich in organic remains, which are remnants of the primary production in the lake. Members of various algal groups form the autochthonous phytoplankton. Chrysophytes, different diatoms, a dinoflagellate species, and the green algae Bot1yococcus and Tetraedron exist. Alginite B is formed by unknown organisms of probably cyanobacterian relationship. Benthic microbial mats are also partially preserved as alginite B. Dinoflagellate cysts are dominant components in a facies which is characterized by the occurrence of alginite A. Chrysophyte cysts and diatom shells form laminar horizons in another facies type. The distinct lamination suggests anually controlled primary production and short timed production of organic matter. Additionally, short term events led to increased sedimentation and rapid termination of the aquatic flora. This was mainly caused by volcanic activities and subsequent erosion and resulted in less laminated sediments.
Semisynthesis and anti-cancer properties of novel honokiol derivatives in human nasopharyngeal carcinoma CNE-2Z cells
Creators: name: Li, Bo-Han
name: Ma, Hui
name: Zhu, Jing
name: Chen, Jie
name: Dai, Yi-Qun
name: Zhang, Xiao-Jing
name: Li, Hong-Mei
name: Wu, Cheng-Zhu
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: In this study, 21 new honokiol derivatives were synthesised, and their anti-cancer properties were investigated. Among these, compound 1g exhibited the most potent cytotoxic activity against human nasopharyngeal carcinoma CNE-2Z cells, human gastric cancer SGC7901 cells, human breast cancer MCF-7 cells, and mouse leydig testicular cancer I-10 lines with IC50 values of 6.04, 7.17, 6.83, and 5.30 μM, respectively. Compared to the parental compound, 1g displayed up to 5.18-fold enhancement of the cytotoxic effect on CNE-2Z cells. We further demonstrated that 1g inhibited cell growth, suppressed migration and invasion, and induced apoptosis of CNE-2Z cells by down-regulating HIF-1α, MMP-2, MMP-9, Bcl-2, Akt and up-regulating Bax protein levels. Transfection of CNE-2Z cells with HIF-1α siRNA reduced cell migration and invasion. In addition, in vivo experiments confirmed that 1g inhibited tumour growth in CNE-2Z cell-xenografted nude mice with low toxicity. Thus, our data suggested that 1g was a potent and safe lead compound for nasopharyngeal carcinoma therapy.
Suppl Material 291118 from Within-population variability in a moth sex pheromone blend, part 2: selection towards fixation
Creators: name: Groot, Astrid T.
name: Wijk, Michiel Van
name: Villacis-Perez, Ernesto
name: Kuperus, Peter
name: Schöfl, Gerhard
name: Veldhuizen, Dennis Van
name: Heckel, David G.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Supplementary information, including 5 tables and 8 figures
Plenty of motion at the bottom: Atomically thin liquid gold membrane
Creators: name: Koskinen, Pekka
name: Korhonen, Topi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The discovery of graphene some ten years ago was the first proof of a free-standing two-dimensional (2D) solid phase. Here, using quantum molecular dynamics simulations of nanoscale gold patches suspended in graphene pores, we predict the existence of an atomically thin, free-standing 2D liquid phase. The liquid phase, enabled by the exceptional planar stability of gold due to relativistic effects, demonstrates extreme fluxionality of metal nanostructures and opens possibilities for a variety of nanoscale phenomena.
description: 9 pages, 4 figures (incl. Supplementary Information, 5 pages and 5 figures) Nanoscale (2015)
Retrograde axonal transport of endogenous phospholipids in rat sciatic nerve
Creators: name: Ray, R. B.
name: Morell, P.
name: Armstrong, R.
name: Toews, A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1985

description: Anterograde axonal transport of phospholipids occurs at a rate of several hundred millimeters per day. However, although labeled precursors are incorporated into phospholipids in the neuronal cell bodies within several hours, these newly synthesized phospholipids are committed to transport over a much longer period of time. Thus, maximal accumulation of radioactive lipids in axons and nerve endings does not occur for several days (e.g., 4 to 7 days in rat optic tract and sciatic nerve). We have now investigated the retrograde axonal transport of endogenous phospholipid molecules in sensory neurons of rat sciatic nerve. Labeled phospholipids were delivered to axons and nerve endings of these cells by anterograde axonal transport following injection of [2-3H] glycerol into the L5 dorsal root ganglion. At various times following precursor injection two ligatures, 9 mm apart, were applied to the mid-thigh region of the sciatic nerve. Animals were sacrificed 3 to 48 hr after nerve ligation, nerves were dissected and sectioned into 5-mm segments, and phospholipid radioactivity in each segment was determined. The time-dependent accumulation of labeled phospholipids distal to the distal ligature demonstrated their retrograde axonal transport. The time course of retrograde transport for these phospholipids was more prolonged and peaked several days later than the time course for the anterograde transport phase. Further information regarding the relationship between radioactive phospholipids arriving at the nerve endings by anterograde transport, and their subsequent "turn-around" and retrograde transport back to the nerve cell bodies, was obtained by analyzing the phospholipid class label distribution of both of these transport phases at various times following precursor injection.(ABSTRACT TRUNCATED AT 250 WORDS)
Suppl. File 5 from Within-population variability in a moth sex pheromone blend, part 2: selection towards fixation.
Creators: name: Groot, Astrid T.
name: Wijk, Michiel Van
name: Villacis-Perez, Ernesto
name: Kuperus, Peter
name: Schöfl, Gerhard
name: Veldhuizen, Dennis Van
name: Heckel, David G.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Aligned nucleotide sequences of the second intron after the start codon of LPAQ delta-11-desaturase of field-collected females. “L allel cDNA” refers to the consensus sequence of the cds allele in the High selection line, “L allel gDNA” to the consensus genomic DNA sequence in the High selection line. “H-allel fam 35-07 gDNA” refers to the genomic DNA sequence of the Low allele in individual 7 of backcross family 35.