cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Migmatite delineates zones of melt flux through the upper crust, Wongwibinda, NSW
Creators: name: Farmer, Michael James
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The small (<20km wide) high-temperature - low-pressure (HTLP) Wongwibinda MetamorphicComplex (WMC), southern New England Orogen, is characterised by an irregular elevatedmetamorphic field gradient (<100°C/km). An examination of the migmatite rocks shows they didnot experienced significant in-situ partial melting, suggesting the abundant leucocratic veins anddykes observed in outcrop are externally derived. Using a combined field and petrographic study,augmented by targeted electron backscatter diffraction (EBSD) and whole-rock geochemicalanalyses, two types of melt pathways through the migmatite have been identified: (i) veining anddyking, and (ii) grain-scale channelled porous flow. The pathways of porous flow are recognisedacross the field area as cm- to outcrop-scale channels, characterised by rare-earth element (REE)metasomatism, mineral mode changes, a randomisation of host crystallographic preferredorientation fabrics and the presence of cuspate K-feldspar pockets. The identification of collapsestructures, due to volume loss as melt-filled dykes and voids drained, demonstrates that some of theinjected melt escaped to structurally higher levels. The two types of melt pathways and theircharacteristics supports a melt flux hypothesis, which is interpreted to drive migmatisation and promote the formation of the elevated thermal field gradient.
A tunable low-energy photon source for high-resolution angle-resolved photoemission spectroscopy
Creators: name: Harter, John W.
name: King, Philip D. C.
name: Monkman, Eric J.
name: Shai, Daniel E.
name: Nie, Yuefeng
name: Uchida, Masaki
name: Burganov, Bulat
name: Chatterjee, Shouvik
name: Shen, Kyle M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We describe a tunable low-energy photon source consisting of a laser-driven xenon plasma lamp coupled to a Czerny-Turner monochromator. The combined tunability, brightness, and narrow spectral bandwidth make this light source useful in laboratory-based high-resolution photoemission spectroscopy experiments. The source supplies photons with energies up to ~7 eV, delivering under typical conditions >10^12 ph/s within a 10 meV spectral bandwidth, which is comparable to helium plasma lamps and many synchrotron beamlines. We first describe the lamp and monochromator system and then characterize its output, with attention to those parameters which are of interest for photoemission experiments. Finally, we present angle-resolved photoemission spectroscopy data using the light source and compare its performance to a conventional helium plasma lamp.
Conceptual design by means of topology optimization
Creators: name: Sotiropoulos, Stefanos
name: Kazakis, George
name: Lagaros, Nikos D.
Publisher: name: Zenodo
Year: 2020
Subjects: topology optimization
conceptual design
static condensation
aesthetic

description: Over recent years, Topology Optimization is used in order to achieve structures oriented via Architectural Conceptual Design. The basic idea behind Topology Optimization is finding the shape of the final structure which optimizes its structural behaviour by distributing material inside the optimized structure, guided by the search for optimal conditions. The presented formulation expands this theory in the field of conceptual design, by the substitution of the material distribution with predefined structural shapes. The form of this structural shapes is independent from the problem formulation, thus a variety of different structures can derive and satisfy the needs of the conceptual design.
Correlation of the fragility of metallic liquids with the high temperature structure, volume, and cohesive energy
Creators: name: Gangopadhyay, A. K.
name: Pueblo, C. E.
name: Dai, R.
name: Johnson, M. L.
name: Ashcraft, R.
name: Van Hoesen, D.
name: Sellers, M.
name: Kelton, K. F.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The thermal expansion coefficients, structure factors, and viscosities of twenty-five equilibrium and supercooled metallic liquids have been measured using an electrostatic levitation (ESL) facility. The structure factor was measured at the Advanced Photon Source, Argonne, using the ESL. A clear connection between liquid fragility and structural and volumetric changes at high temperatures is established; the observed changes are larger for the more fragile liquids. It is also demonstrated that the fragility of metallic liquids is determined to a large extent by the cohesive energy and is, therefore, predictable. These results are expected to provide useful guidance in the future design of metallic glasses.
Ballistic front dynamics after joining two semi-infinite quantum Ising chains
Creators: name: Perfetto, Gabriele
name: Gambassi, Andrea
Publisher: name: arXiv
Year: 2017
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We consider two semi-infinite quantum Ising chains initially at thermal equilibrium at two different temperatures and subsequently joined by an interaction between their end points. Transport properties such as the heat current are determined by the dynamics of the left- and right-moving fermionic quasi-particles which characterize the ensuing unitary dynamics. Within the so-called semi-classical space-time scaling limit we extend known results by determining the full space and time dependence of the density and current of energy and of fermionic quasi-particles. Upon approaching the edge of the propagating front, these quantities as well as the two-point correlation function display qualitatively different behaviors depending on the transverse field of the chain being critical or not. While in the latter case corrections to the leading behavior are described, as expected, by the Airy kernel, in the former a novel scaling form emerges with universal features.
description: 29 pages, 11 figures
Agricultural Labor in North America: Policies and Problems, 1979-85
Creators: name: Beebe, Charles N.
name: Beebe, Charles N.
Publisher: name: Unknown
Year: 1986
Subjects: Agricultural and Food Policy
Labor and Human Capital

description: Excerpts from the Preface: Agricultural labor policies and problems are among the major concerns facing the American farmer. This bibliography brings together a collection of books and papers on a wide variety of issues of interest to agricultural policymakers throughout the North American Continent. Subject matter is divided according to the section headings currently used in AGRICOLA (Agricultural On-Line Access), the database of the National Agricultural Library. Each entry appears under as many section headings as were assigned to the document at the time it was entered into the collection.
Photometric and radial-velocity time-series of RR Lyrae stars in M3: analysis of single-mode variables
Creators: name: Jurcsik, J.
name: Smitola, P.
name: Hajdu, G.
name: Sódor, Á.
name: Nuspl, J.
name: Kolenberg, K.
name: Fűrész, G.
name: Balázs, L. G.
name: Pilachowski, C.
name: Saha, A.
name: Moór, A.
name: Kun, E.
name: Pál, A.
name: Bakos, J.
name: Kelemen, J.
name: Kovács, T.
name: Kriskovics, L.
name: Sárneczky, K.
name: Szalai, T.
name: Szing, A.
name: Vida, K.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present the first simultaneous photometric and spectroscopic investigation of a large set of RR Lyrae variables in a globular cluster. The radial-velocity data presented comprise the largest sample of RVs of RR Lyrae stars ever obtained. The target is M3; $BVI_{\mathrm{C}}$ time-series of 111 and $b$ flux data of further 64 RRab stars, and RV data of 79 RR Lyrae stars are published. Blazhko modulation of the light curves of 47 percent of the RRab stars are detected. The mean value of the center-of-mass velocities of RR Lyrae stars is $-146.8$ km s$^{-1}$ with 4.52 km s$^{-1}$ standard deviation, which is in good agreement with the results obtained for the red giants of the cluster. The ${Φ_{21}}^{\mathrm RV}$ phase difference of the RV curves of RRab stars is found to be uniformly constant both for the M3 and for Galactic field RRab stars; no period or metallicity dependence of the ${Φ_{21}}^{\mathrm RV}$ is detected. The Baade-Wesselink distances of 26 non-Blazhko variables with the best phase-coverage radial-velocity curves are determined; the corresponding distance of the cluster, $10480\pm210$ pc, agrees with the previous literature information. A quadratic formula for the $A_{\mathrm{puls}}-A_V$ relation of RRab stars is given, which is valid for both OoI and OoII variables. We also show that the $(V-I)_0$ of RRab stars measured at light minimum is period dependent, there is at least 0.1 mag difference between the colours at minimum light of the shortest- and longest-period variables.
description: 22 pages, 14 figures, accepted for publication in the Monthly Notices of the Royal Astronomical Society
Quantum Effects in the Nonlinear Response of Graphene Plasmons
Creators: name: Cox, Joel D.
name: Silveiro, Iván
name: de Abajo, F. Javier García
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The ability of graphene to support long-lived, electrically tunable plasmons that interact strongly with light, combined with its highly nonlinear optical response, has generated great expectations for application of the atomically-thin material to nanophotonic devices. These expectations are mainly reinforced by classical analyses performed using the response derived from extended graphene, neglecting finite-size and nonlocal effects that become important when the carbon layer is structured on the nanometer scale in actual device designs. Here we show that finite-size effects produce large contributions that increase the nonlinear response of nanostructured graphene to significantly higher levels than those predicted by classical theories. We base our analysis on a quantum-mechanical description of graphene using tight-binding electronic states combined with the random-phase approximation. While classical and quantum descriptions agree well for the linear response when either the plasmon energy is below the Fermi energy or the size of the structure exceeds a few tens of nanometers, this is not always the case for the nonlinear response, and in particular, third-order Kerr-type nonlinearities are generally underestimated by the classical theory. Our results reveal the complex quantum nature of the optical response in nanostructured graphene, while further supporting the exceptional potential of this material for nonlinear nanophotonic devices.
description: 18 pages, 8 figures
Diagnostic accuracy of the Montgomery–Åsberg Depression Rating Scale parent report among adolescent psychiatric outpatients
Creators: name: C. Torres Soler
name: S. Olofsdotter
name: S. Vadlin
name: M. Ramklint
name: K. W. Nilsson
name: K. Sonnby
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background: The diagnostic accuracy of the parent report of the Montgomery–Åsberg Depression Rating Scale (MADRS-P) for the screening of major depressive disorder (MDD) in adolescents has not been evaluated. Aim: The aim was to explore the psychometric properties and diagnostic accuracy of the MADRS-P in general child and adolescent psychiatric outpatient services in Sweden. Method: The study was a validation and a diagnostic accuracy study. Consecutive adolescent psychiatric patients (n = 101, 45 males, mean age 15 years) were assessed with a diagnostic interview, the Kiddie Schedule of Affective Disorders and Schizophrenia for School-Age Children – Present and Lifetime version (K-SADS-PL), as a reference test. Thereafter, their parents reported on the MADRS-P. Both categorical MDD diagnoses and dimensional MDD symptom severity scores were obtained from the K-SADS-PL. Results: The internal consistency of the MADRS-P, measured with Cronbach’s alpha, was 0.846. The concurrent validity, assessed by Spearman’s rho as a correlation between the K-SADS MDD symptom severity score and the MADRS-P score, was 0.580. The area under the curve in a receiver operating characteristic analysis for all participants was 0.786 (95% confidence interval 0.694–0.877, p Conclusions: The parent-rated MADRS-P showed similar psychometric properties as previously shown for the self-rated MADRS-S in adults. Although the MADRS-P has acceptable diagnostic accuracy for screening for MDD in adolescents in a general psychiatric setting, it cannot be used alone for diagnosing MDD.
Design, synthesis and herbicidal activity of novel cyclic phosphonates with diaryl ethers containing pyrimidine
Creators: name: Zhang, Shasha
name: Guo, Xinjuan
name: Zhou, Yuan
name: Yang, Yalan
name: Peng, Hao
name: He, Hongwu
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Plant Biology

description: Thirteen novel cyclic phosphates were rationally designed and synthesized by introducing diary ethers containing pyrimidine. All the target compounds were characterized by 1H, 13C, 31P NMR and HRMS. The test of herbicidal activity indicated that most of the compounds showed good herbicidal activities against Amaranthus retroflexus. The compounds IA-2 (1-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)propyl-2-((4,6-dimethoxypyrimidin-2-yl)oxy)benzoate) and IA-3 ((5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)(phenyl)methyl-2-((4,6-dimethoxypyrimidin-2-yl)oxy)benzoate) exhibited remarkable post-emergency herbicidal activity against the tested monocotyledonous weed at the dosage of 112.5 g ai/ha.
Kaluza-Klein bulk viscous fluid cosmological models and the validity of the second law of thermodynamics in $f(R, T)$ gravity
Creators: name: Samanta, G. C.
name: Myrzakulov, R.
name: Shah, Parth
Publisher: name: arXiv
Year: 2016
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The authors considered the bulk viscous fluid in $f(R, T)$ gravity within the framework of Kaluza-Klein space time. The bulk viscous coefficient $(ξ)$ expressed as $ξ=ξ_0+ξ_1\frac{\dot{a}}{a}+ξ_2\frac{\ddot{a}}{\dot{a}}$, where $ξ_0$, $ξ_1$ and $ξ_2$ are positive constants. We take $p=(γ-1)ρ$, where $0\leγ\le2$ as an equation of state for perfect fluid. The exact solutions to the corresponding field equations are given by assuming a particular model of the form of $f(R, T)=R+2f(T)$, where $f(T)=λT$, $λ$ is constant. We studied the cosmological model in two stages, in first stage: we studied the model with no viscosity, and in second stage: we studied the model involve with viscosity. The cosmological model involve with viscosity is studied by five possible scenarios for bulk viscous fluid coefficient $(ξ)$. The total bulk viscous coefficient seems to be negative, when the bulk viscous coefficient is proportional to $ξ_2\frac{\ddot{a}}{\dot{a}}$, hence the second law of thermodynamics is not valid, however, it is valid with the generalized second law of thermodynamics. The total bulk viscous coefficient seems to be positive, when, the bulk viscous coefficient is proportional to $ξ=ξ_1\frac{\dot{a}}{a}$, $ξ=ξ_1\frac{\dot{a}}{a}+ξ_2\frac{\ddot{a}}{\dot{a}}$ and $ξ=ξ_0+ξ_1\frac{\dot{a}}{a}+ξ_2\frac{\ddot{a}}{\dot{a}}$, so the second law of thermodynamics and the generalized second law of thermodynamics is satisfied throughout the evolution. We calculate statefinder parameters of the model and observed that, it is different from the $\wedge$CDM model. Finally, some physical and geometrical properties of the models are discussed.
description: 20 pages, 10 figures. reference added, text clean, abstract modified
Holographic Subregion Complexity for Singular Surfaces
Creators: name: Bakhshaei, Elaheh
name: Mollabashi, Ali
name: Shirzad, Ahmad
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Recently holographic prescriptions are proposed to compute quantum complexity of a given state in the boundary theory. A specific proposal known as `holographic subregion complexity' is supposed to calculate the the complexity of a reduced density matrix corresponding to a static subregion. We study different families of singular subregions in the dual field theory and find the divergence structure and universal terms of holographic subregion complexity for these singular surfaces. We find that there are new universal terms, logarithmic in the UV cutoff, due to the singularities of a family of surfaces including a kink in (2+1)-dimension and cones in even dimensional field theories. We find examples of new divergent terms such as square logarithm and negative powers times the logarithm of the UV cut-off parameter.
description: 30 pages
A core UPS molecular complement implicates unique endocytic compartments at the parasite-host interface in Giardia lamblia
Creators: name: Balmer, Erina A.
name: Wirdnam, Corina D.
name: Faso, Carmen
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Physiology
subject: Evolutionary Biology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Unconventional protein secretion (UPS) plays important roles in cell physiology. In contrast to canonical secretory routes, UPS does not generally require secretory signal sequences and often bypasses secretory compartments such as the ER and the Golgi apparatus. Giardia lamblia is a protist parasite with reduced subcellular complexity which releases several proteins, some of them virulence factors, without canonical secretory signals. This implicates UPS at the parasite-host interface. No dedicated machinery nor mechanism(s) for UPS in Giardia are currently known, although speculations on the involvement of endocytic organelles called PV/PECs, have been put forth. To begin to address the question of whether PV/PECs are implicated in virulence-associated UPS and to define the composition of molecular machinery involved in protein release, we employed affinity purification and mass spectrometry, coupled to microscopy-based subcellular localization and signal correlation quantification to investigate the interactomes of 11 reported unconventionally-secreted proteins, all predicted to be cytosolic. A subset of these associates to PV/PECs. Extended and validated interactomes point to a core PV/PECs-associated UPS machinery, which includes uncharacterized and Giardia-specific coiled-coil proteins and NEK kinases. Finally, a subset of the alpha-giardin protein family was enriched in all PV/PECs-associated protein interactomes, highlighting a previously unappreciated role for these proteins at PV/PECs and in UPS. Taken together, our results provide the first characterization of a virulence-associated UPS protein complex in Giardia lamblia at PV/PECs, suggesting a novel link between these primarily endocytic and feeding organelles and UPS at the parasite-host interface.
Thermodynamics of a time dependent and dissipative oval billiard: a heat transfer and billiard approach
Creators: name: Leonel, Edson D.
name: Galia, Marcus Vinicius Camillo
name: Barreiro, Luiz Antonio
name: Oliveira, Diego F. M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We study some statistical properties for the behavior of the average squared velocity -- hence the temperature -- for an ensemble of classical particles moving in a billiard whose boundary is time dependent. We assume the collisions of the particles with the boundary of the billiard are inelastic leading the average squared velocity to reach a steady state dynamics for large enough time. The description of the stationary state is made by using two different approaches: (i) heat transfer motivated by the Fourier law and, (ii) billiard dynamics using either numerical simulations and theoretical description.
description: Published -Physical Review E, 2016
Dis-abling the hearing line: deafness, deaf studies and creative nonfiction
Creators: name: Kirkness, Jessica Leigh
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This thesis is an investigation into the intersections of deafness and literature. It is concerned with the discursive construction of the deaf individual, and the potential representations of deafness in written prose. As a grandchild of two deaf adults, my lived experience and interaction with deafness significantly informs this work. I’m exploring, both through research and creative practice, my grandparents’ lived experiences of being deaf in a hearing world, and the ways in which creative non-fiction writing might function as a unique form to represent this experience. My project involves a two-pronged approach that can be separated into an analytical critique of current literature, and a creative-practice research component, whereby I employ and experiment with techniques unique to creative non-fiction in order to produce pieces of critically informed personal narrative. The philosophical and political thrust of my study is grounded in a desire to illuminate the multitudinous ways of knowing and engaging sensorially with the world, in order to negotiate and narrow, the interstitial space between deaf and hearing people. Engaging with the field of Deaf Studies, I attempt to disrupt the hierarchical binaries of the able/disabled body and intervene in the various discourses that have constructed deafness as a form of depravity and deficit.
The photographic encounter: picturing difference and distinction in Metropolitan England and in early twentieth-century English travelogues
Creators: name: DeCourcy, Elisa
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This dissertation examines the communicative potential and evidential authority of photographic images taken in England during the nineteenth century and those exposed by English men and women abroad, as illustrations for their travelogue publication, during the early twentieth century. It begins by charting the rise of portraiture as an industry and observes the adoption of photography as a tool for classifying people in legal, scientific and scholarly institutions throughout the Victorian period. This project is particularly concerned with how the innovation of hand-held camera technology and the expansion of photographic practice to an amateur marketplace affected the composition conventions used in photographing people and photography’s documentary currency. The dissertation takes as its case study the rise of photography as the preferred illustrative media for English authored travelogues in the opening decades of the twentieth century. The travelogue retailed as a popular genre of non-fiction, premised on documenting the excursions of English travellers who ventured beyond the tourist highways and metropolitan centres of the colonial world. These publications, produced by both men and women, encapsulate important commentaries on English national imagining as well as unique stories of cross-cultural encounter. I argue that travellers drew from the traditions from nineteenth century portrait industries as well as visual languages found in contemporary periodicals, advertising ephemera, anthropological archives and popular literature to make their encounters with ‘coloured’ peoples meaningful for their assumed, metropolitan-based reader. This project seeks to contribute to the plethora of scholarship on European travel literature produced during the last two decades which, up until this point, has under-utilised photography as part of its analysis. Moreover, it engages with the concerns of New Imperial History that, as a body of scholarship, examines the British experience of Empire as one that linked the metropole and the colonial domains in intricate and interdependent ways.
Comparative global B cell receptor repertoire difference induced by SARS-CoV-2 infection or vaccination via single-cell V(D)J sequencing
Creators: name: He, Bing
name: Liu, Shuning
name: Xu, Mengxin
name: Hu, Yunqi
name: Lv, Kexin
name: Wang, Yuanyuan
name: Ma, Yong
name: Zhai, Yanmei
name: Yue, Xinyu
name: Liu, Lin
name: Lu, Hongjie
name: Zhou, Siwei
name: Li, Pengbin
name: Mai, Guoqin
name: Huang, Xiaoping
name: Li, Chenhang
name: Chen, Shifeng
name: Ye, Shupei
name: Zhao, Pingsen
name: Yang, Yuedong
name: Li, Xinhua
name: Jie, Yusheng
name: Shi, Mang
name: Yang, Jingyi
name: Shu, Yuelong
name: Chen, Yao-Qing
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Dynamic changes of the paired heavy and light chain B cell receptor (BCR) repertoire provide an essential insight into understanding the humoral immune response post-SARS-CoV-2 infection and vaccination. However, differences between the endogenous paired BCR repertoire kinetics in SARS-CoV-2 infection and previously recovered/naïve subjects treated with the inactivated vaccine remain largely unknown. We performed single-cell V(D)J sequencing of B cells from six healthy donors with three shots of inactivated SARS-CoV-2 vaccine (BBIBP-CorV), five people who received the BBIBP-CorV vaccine after having recovered from COVID-19, five unvaccinated COVID-19 recovered patients and then integrated with public data of B cells from four SARS-CoV-2-infected subjects. We discovered that BCR variable (V) genes were more prominently used in the SARS-CoV-2 exposed groups (both in the group with active infection and in the group that had recovered) than in the vaccinated groups. The VH gene that expanded the most after SARS-CoV-2 infection was IGHV3-33, while IGHV3-23 in the vaccinated groups. SARS-CoV-2-infected group enhanced more BCR clonal expansion and somatic hypermutation than the vaccinated healthy group. A small proportion of public clonotypes were shared between the SARS-CoV-2 infected, vaccinated healthy, and recovered groups. Moreover, several public antibodies had been identified against SARS-CoV-2 spike protein. We comprehensively characterize the paired heavy and light chain BCR repertoire from SARS-CoV-2 infection to vaccination, providing further guidance for the development of the next-generation precision vaccine.
Characterising mutant Cyclin F in the development of amyotrophic lateral sclerosis
Creators: name: Rayner, Stephanie
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Amyotrophic lateral sclerosis is a relentless neurodegenerative disease typically leading to death of patients within 5 years from onset. Recently, several ALS-causing gene mutations in CCNF, the gene encoding Cyclin F have been identified. We have focused on the substitution from serine to glycine at amino acid 621 and show that mutation affects the functionality of the ubiquitin ligase, SCF Cyclin F. Specifically, the mutation impacts proteostasis of a known substrate, RRM2 (ribonucleotide reductase family member 2). Although the abundance of RRM2 is not affected, there is increasing abundance of ubiquitinated RRM2 in transfected Neuro-2A cells after 24 hours post-transfection. Using a label-free proteomic workflow, a total of 60 differentially expressed proteins were associated with mutant Cyclin F-mCherry expressing cells after 8 and 24 hours post-transfection. Many changes are functionally involved in protein translation and RNA processing, which is consistent with ALS pathogenesis. Using a workflow consisting of SDS-PAGE and LC-MS/MS we also obtained protein aggregate profiles that are linked to the mutation in Neuro-2A cells under heat-stress.Notably, Septin 2 was increasingly insoluble in association with mutant Cyclin F. This is a strong candidate for validation studies, as it is known to form insoluble aggregates within Parkinsonism models.
Emergence of mcr-8.2-harboring hypervirulent ST412 Klebsiella pneumoniae strain from pediatric sepsis: A comparative genomic survey
Creators: name: Liu, Ruishan
name: Xu, Hao
name: Zhao, Junhui
name: Hu, Xinjun
name: Wu, Lingjiao
name: Qiao, Jie
name: Ge, Haoyu
name: Guo, Xiaobing
name: Gou, Jianjun
name: Zheng, Beiwen
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Emerging mobile colistin resistance (mcr) genes pose a significant threat to public health for colistin was used as the last resort to treat multidrug-resistant (MDR) pathogenic bacterial infections. Hypervirulent Klebsiella pneumoniae (hvKP) is a clinically significant pathogen resulting in highly invasive infections, often complicated by devastating dissemination. Worryingly, the untreatable and severe infections caused by mcr-harbouring hvKP leave the selection of antibiotics for clinical anti-infective treatment in a dilemma. Herein, we screened 3,461 isolates from a tertiary teaching hospital from November 2018 to March 2021, and an mcr-8.2-harbouring hvKP FAHZZU2591 with a conjugative plasmid was identified from paediatric sepsis. This is the first report of MCR-8-producing hvKP from paediatric sepsis to our best knowledge. The susceptibility, genetic features, and plasmid profiles of the isolate were investigated. Further, we assessed the virulence potential of FAHZZU2591 and verified its pathogenicity and invasive capacity using a mouse model. The phylogenetic analysis of mcr-8-bearing K. pneumoniae revealed that China is the predominant reservoir of the mcr-8 gene, and the clinic is the primary source. Our work highlights the risk for the spread of mcr-positive hvKP in clinical, especially in paediatric sepsis, and the persistent surveillance of colistin-resistance hvKP is urgent.
Flexible Delivery of Advanced Legal Research: A Skills Unit for Later Year Undergraduate Law Students
Creators: name: Smith, Lisa
name: Tucker, Kay
Publisher: name: Monash University
Year: 2017
Subjects: subject: 180121 Legal Practice, Lawyering and the Legal Profession
subject: FOS: Law

description: Published in (2004) 12(3) Australian Law Librarian 35, Co-authored with Kay Tucker.
Interaction of molecular nitrogen with Free-Electron-Laser radiation
Creators: name: Banks, H. I. B.
name: Little, D. A.
name: Tennyson, J.
name: Emmanouilidou, A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We compute molecular continuum orbitals in the single center expansion scheme. We then employ these orbitals to obtain molecular Auger rates and single-photon ionization cross sections to study the interaction of N2 with Free-Electron-Laser (FEL) pulses. The nuclei are kept fixed. We formulate rate equations for the energetically allowed molecular and atomic transitions and we account for dissociation through additional terms in the rate equations. Solving these equations for different parameters of the FEL pulse, allows us to identify the most efficient parameters of the FEL pulse for obtaining the highest contribution of double core hole states (DCH) in the final atomic ion fragments. Finally we identify the contribution of DCH states in the electron spectra and show that the DCH state contribution is more easily identified in the photo-ionization rather than the Auger transitions.
Comparative global B cell receptor repertoire difference induced by SARS-CoV-2 infection or vaccination via single-cell V(D)J sequencing
Creators: name: He, Bing
name: Liu, Shuning
name: Xu, Mengxin
name: Hu, Yunqi
name: Lv, Kexin
name: Wang, Yuanyuan
name: Ma, Yong
name: Zhai, Yanmei
name: Yue, Xinyu
name: Liu, Lin
name: Lu, Hongjie
name: Zhou, Siwei
name: Li, Pengbin
name: Mai, Guoqin
name: Huang, Xiaoping
name: Li, Chenhang
name: Chen, Shifeng
name: Ye, Shupei
name: Zhao, Pingsen
name: Yang, Yuedong
name: Li, Xinhua
name: Jie, Yusheng
name: Shi, Mang
name: Yang, Jingyi
name: Shu, Yuelong
name: Chen, Yao-Qing
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Dynamic changes of the paired heavy and light chain B cell receptor (BCR) repertoire provide an essential insight into understanding the humoral immune response post-SARS-CoV-2 infection and vaccination. However, differences between the endogenous paired BCR repertoire kinetics in SARS-CoV-2 infection and previously recovered/naïve subjects treated with the inactivated vaccine remain largely unknown. We performed single-cell V(D)J sequencing of B cells from six healthy donors with three shots of inactivated SARS-CoV-2 vaccine (BBIBP-CorV), five people who received the BBIBP-CorV vaccine after having recovered from COVID-19, five unvaccinated COVID-19 recovered patients and then integrated with public data of B cells from four SARS-CoV-2 infected subjects. We discovered that BCR variable (V) genes were more prominently used in the SARS-CoV-2 exposed groups (both in the group with active infection and in the group that had recovered) than in the vaccinated groups. The VH gene that expanded the most after SARS-CoV-2 infection was IGHV3-33, while IGHV3-23 in the vaccinated groups. SARS-CoV-2 infected group enhanced more BCR clonal expansion and somatic hypermutation than the vaccinated healthy group. A small proportion of public clonotypes were shared between the SARS-CoV-2 infected, vaccinated healthy, and recovered groups. Moreover, several public antibodies had been identified against SARS-CoV-2 spike protein. We comprehensively characterize the paired heavy and light chain BCR repertoire from SARS-CoV-2 infection to vaccination, providing further guidance for development of the next-generation precision vaccine.
Recreating the images of Chan Master Huineng: a systemic-functional approach to translations of the Platform sutra
Creators: name: Yu, Hailing
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This research applies systemic functional linguistics (SFL) to the comparison of four English translations of the Platform Sutra (Wong 1930; Heng 1977; Cleary 1998 and Cheng 2011), in the field of descriptive translation studies. The Platform Sutra is an ancient Chan Buddhist text that records the public sermons and personal conversations of the Chan master Huineng (638-713). The focus of the research is on the image of Huineng recreated in each translation, with the concept of 'image' defined as the semantic consequence of patterned lexicogrammatical choices in translating the Platform Sutra. The study specifically answers the following two research questions: 1. To what extent is the image of Huineng represented differently in the translations of the Platform Sutra? What particular image is recreated in each translation and how did the translator achieve this? and, 2. Why is a certain image of Huineng recreated in one translation but not the others? The first question is to be answered by conducting a bottom-up analysis from the level of lexicogrammar to that of semantics; and the second question can only be satisfactorily answered by taking the context into consideration. The methodology of the study integrates quantitative and qualitative analyses, with the analytical tools adopted being SysFan (Wu 2000), SysConc (Wu 2003) and Wmatrix (Rayson 2003). The analyses of the four translations are conducted in the form of journal articles from the perspectives of verbs of saying, personal pronouns, MOOD and MODALITY, multimodality and evaluation, and textual complexity, which are within the ideational, interpersonal and textual metafunctions respectively. Results show that different images of the same Chan master Huineng have been recreated in each translation, which are reflected through the recurrent lexicogrammatical choices in the ideational, interpersonal and textual systems, though the influence of each system varies. Both the recreating of images and the lexicogrammatical choices can be further interpreted by taking the context of translation (Field, Tenor, Mode) into consideration. The significance of the present study lies in both its comprehensive analysis of different translations of the same source text from a systemic functional perspective, and its emphasis on religious texts as an invaluable resource for both SFL and translation studies.
Phase diagram of multiferroic KCu$_3$As$_2$O$_7$(OD)$_3$
Creators: name: Nilsen, Gøran J.
name: Simonet, Virginie
name: Colin, Claire V.
name: Okuma, Ryutaro
name: Okamoto, Yoshihiko
name: Tokunaga, Masashi
name: Hansen, Thomas C.
name: Khalyavin, Dmitry D.
name: Hiroi, Zenji
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The layered compound KCu$_3$As$_2$O$_7$(OD)$_3$, comprising distorted kagome planes of $S=1/2$ Cu$^{2+}$ ions, is a recent addition to the family of type-II multiferroics. Previous zero field neutron diffraction work has found two helically ordered regimes in \kns, each showing a distinct coupling between the magnetic and ferroelectric order parameters. Here, we extend this work to magnetic fields up to $20$~T using neutron powder diffraction, capacitance, polarization, and high-field magnetization measurements, hence determining the $H-T$ phase diagram. We find metamagnetic transitions in both low temperatures phases around $μ_0 H_c \sim 3.7$~T, which neutron powder diffraction reveals to correspond to a rotation of the helix plane away from the easy plane, as well as a small change in the propagation vector. Furthermore, we show that the sign of the ferroelectric polarization is reversible in a magnetic field, although no change is observed (or expected on the basis of the magnetic structure) due to the transition at $3.7$~T. We finally justify the temperature dependence of the polarization in both zero-field ordered phases by a symmetry analysis of the free energy expansion.
Emergence of mcr-8.2-harboring hypervirulent ST412 Klebsiella pneumoniae strain from pediatric sepsis: a comparative genomic survey
Creators: name: Liu, Ruishan
name: Xu, Hao
name: Zhao, Junhui
name: Hu, Xinjun
name: Wu, Lingjiao
name: Qiao, Jie
name: Ge, Haoyu
name: Guo, Xiaobing
name: Gou, Jianjun
name: Zheng, Beiwen
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Emerging mobile colistin resistance (mcr) genes pose a significant threat to public health for colistin was used as the last resort to treat multidrug-resistant (MDR) pathogenic bacterial infections. Hypervirulent Klebsiella pneumoniae (hvKP) is a clinically significant pathogen resulting in highly invasive infections, often complicated by devastating dissemination. Worryingly, the untreatable and severe infections caused by mcr-harboring hvKP lead to the selection of antibiotics for clinical anti-infective treatment in a dilemma. Herein, we screened 3,461 isolates from a tertiary teaching hospital from November 2018 to March 2021, and an mcr-8.2-harboring hvKP FAHZZU2591 with a conjugative plasmid was identified from pediatric sepsis. This is the first report of MCR-8-producing hvKP from pediatric sepsis to our best knowledge. The susceptibility, genetic features, and plasmid profiles of the isolate were investigated. Further, we assessed the virulence potential of FAHZZU2591 and verified its pathogenicity and invasive capacity using a mouse model. The phylogenetic analysis of mcr-8-bearing K. pneumoniae revealed that China is the predominant reservoir of the mcr-8 gene, and the clinic is the primary source. Our work highlights the risk for the spread of mcr-positive hvKP in clinical, especially in pediatric sepsis, and the persistent surveillance of colistin-resistance hvKP is urgent.
Detecting planet pairs in mean motion resonances via astrometry method
Creators: name: Wu, Dong-Hong
name: Liu, Hui-Gen
name: Yu, Zhou-Yi
name: Hui-Zhang
name: Zhou, Ji-Lin
Publisher: name: arXiv
Year: 2016
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: GAIA leads us to step into a new era with a high astrometry precision of 10 uas. Under such a precision, astrometry will play important roles in detecting and characterizing exoplanets. Specially, we can identify planet pairs in mean motion resonances(MMRs) via astrometry, which constrains the formation and evolution of planetary systems. In accordance with observations, we consider two Jupiters or two super-Earths systems in 1:2, 2:3 and 3:4 MMRs. Our simulations show the false alarm probabilities(FAPs) of a third planet are extremely small while the real two planets can be good fitted with signal-to-noise ratio(SNR)> 3. The probability of reconstructing a resonant system is related with the eccentricities and resonance intensity. Generally, when SNR >= 10, if eccentricities of both planets are larger than 0.01 and the resonance is quite strong, the probabilities to reconstruct the planet pair in MMRs >= 80%. Jupiter pairs in MMRs are reconstructed more easily than super-Earth pairs with similar SNR when we consider the dynamical stability. FAPs are also calculated when we detect planet pairs in or near MMRs. FAPs for 1:2 MMR are largest, i.e., FAPs > 15% when SNR <= 10. Extrapolating from the Kepler planet pairs near MMRs and assuming SNR to be 3, we will discover and reconstruct a few tens of Jupiter pairs and hundreds of super-Earth pairs in 2:3 and 1:2 MMRs within 30 pc. We also compare the differences between even and uneven data cadence and find that planets are better measured with more uniform phase coverage.
description: 22 pages, 18 figures. Published in ApJ
Additional file 3: Table S2. of miR-105/93-3p promotes chemoresistance and circulating miR-105/93-3p acts as a diagnostic biomarker for triple negative breast cancer
Creators: name: Hao-Yi Li
name: Jui-Lin Liang
name: Yao-Lung Kuo
name: Hao-Hsien Lee
name: Calkins, Marcus
name: Hong-Tai Chang
name: Forn-Chia Lin
name: Yu-Chia Chen
name: Tai-I Hsu
name: Hsiao, Michael
name: Ger, Luo-Ping
name: Pei-Jung Lu
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer

description: Univariate and multivariate analysis of clinical features and four oncomiRs associated with overall survival. (DOCX 12 kb)
Modelling radio frequency GaN HEMT using physics-based model in AWR
Creators: name: Panuraj, Gajan
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The modelling of an ASM GaN HEMT in low cost and high durability with lon life periods will definitely attract the industrial development in the semiconductor mass production activities. There are many companies involved in the mass production of GaN transistors ; due to this reason GaN transistors are available in the common market with various brand names. The research on Modelling radio frequency GaN HEMT using physics-based model in AWRto extract the DC parameters and RF parameters are widely analysed in this thesis research paper. The first portion of this research paper is giving background knowledge to the reader regarding the GaN transistor and RF performance. Then the body of this research paper would contain the ASM GaN HEMT model , modelling, application of Verilog-A language which will be incorporated with AWR in this project, simulation and tuned results of the DC parameter and RF parameter extraction with a GaN model and AWR IV characteristics and S-parameters. Then the report will further discuss the results, future work on modelling and conclusion of the GaN HEMT modelling.
‘Chemical is Not Impossible’: the development of the Chemical Agent Monitor and the resulting paradigm shift in chemical warfare agent detection
Creators: name: E. E. Fowler, Abigail
Publisher: name: University of Leicester
Year: 2024

description: Since their first use in 1915, the threat of chemical weapons has driven a need for defensive capabilities for detection and warning systems. Meeting this need, a series of paradigm shifts in detection technology occurred between World War I and the 1980s and ending with the Chemical Agent Monitor (CAM) as it was deployed in 1985. This thesis evaluates CAM as a case study within the larger history of chemical warfare agent detection, examining how its success was brought about by the confluence of individual, government, private, and national relationships.The research makes use of a new collection of oral history interviews with former government and private industry scientists and engineers who worked on the development of CAM and related technologies between 1970 and 1990. This original source material is used alongside archival documents, government and private papers, photos, and archival videos to present the first historical study of chemical warfare agent detection. It builds the narrative of the larger world of detection, then focuses on CAM as a case study through the different lenses of oral and archival sources to build a picture of the culture, relationships, institutions, and science which enabled CAM’s success.This study shows the importance of vapour detection in chemical warfare and the motivations which drove its development. It provides the first narrative of chemical warfare agent detection and proposes a five-step process of detection development for detection technologies from this overview. It demonstrates the critical role of individual, institutional, and US-UK relationships to the successful paradigm shift in detector technology which CAM represented, detailing the approval process for CAM and its operational and tactical value to UK and Allied chemical warfare capabilities.