cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Analogues of 2′-hydroxychalcone with modified C4-substituents as the inhibitors against human acetylcholinesterase
Creators: name: Sukumaran, Sri Devi
name: Nasir, Shah Bakhtiar
name: Tee, Jia Ti
name: Buckle, Michael J. C.
name: Othman, Rozana
name: Rahman, Noorsaadah Abd.
name: Lee, Vannajan Sanghiran
name: Bukhari, Syed Nasir Abbas
name: Chee, Chin Fei
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Hematology

description: A series of C4-substituted tertiary nitrogen-bearing 2′-hydroxychalcones were designed and synthesised based on a previous mixed type acetylcholinesterase inhibitor. Majority of the 2′-hydroxychalcone analogues displayed a better inhibition against acetylcholinesterase (AChE) than butyrylcholinesterase (BuChE). Among them, compound 4c was identified as the most potent AChE inhibitor (IC50: 3.3 µM) and showed the highest selectivity for AChE over BuChE (ratio >30:1). Molecular docking studies suggested that compound 4c interacts with both the peripheral anionic site (PAS) and catalytic anionic site (CAS) regions of AChE. ADMET analysis confirmed the therapeutic potential of compound 4c based on its blood–brain barrier penetrating. Overall, the results suggest that this 2′-hydroxychalcone deserves further investigation into the therapeutic lead for Alzheimer’s disease (AD).
Albinen gegen das Rhonethal
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1860

description: nach Bühlmann ; [Kopie Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Application of the extended Pitzer equation to nuclear fuel reprocessing
Creators: name: Wavada, Matthew J.
Publisher: name: University of Utah
Year: 2012
Subjects: Distribution coefficient
Extraction
Nuclear forensics
Pitzer equation

description: A rigorous method for calculating the activity coefficients of ions in aqueous solutions during nuclear fuel reprocessing is presented along with predictions of the model during the criticality event that took place on October 17, 1978 at the Idaho Chemical Processing Plant. Determination and validation of the parameters for the extended Pitzer model were performed using OLI database simulations to supplement available experimental data. Values for the parameters for the neutral species uranyl nitrate (UO2(NO3)2) and nitric acid (HNO3) from Hlushak et al. were determined to accurately predict the activity coefficients of these species without the aluminum nitrate buffer solution present. The parameters for aluminum nitrate (Al(NO3)3) from Accornero and Marini needed slight modifications for the UO2(NO3)2/HNO3/Al(NO3)3/H2O system used in the extraction process during the event under consideration. The extended Pitzer model was used to calculate the equilibrium constant for extraction at steady?state and then used to predict distribution coefficients in the case of decreasing Al(NO3)3 buffer solution concentrations that led to the accident. Finally, the equilibrium constant was modified to determine the stage?wise distribution based on the uranium mass balance.
Auf der Rieder Furca gegen das Weisshorn
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1860
Subjects: Wallis

description: nach Bühlmann ; [Kopie Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Interspecific hybridization in tomato influences endogenous viral sRNAs and alters gene expression
Creators: name: Lopez-Gomollon, Sara
name: Müller, Sebastian Y
name: Baulcombe, David
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Research
Plant RNA Biology
Small RNAs
Hybridization
Changes in gene expression
Endogenous pararetroviruses
Transposable elements
DCL2 (Dicer-like 2)
RNA silencing

description: Funder: Fondazione Internazionale Premio Balzan; doi: http://dx.doi.org/10.13039/100008995
description: Abstract: Background: Hybridization is associated with the activation of transposable elements and changes in the patterns of gene expression leading to phenotypic changes. However, the underlying mechanisms are not well understood. Results: Here, we describe the changes to the gene expression in interspecific Solanum hybrids that are associated with small RNAs derived from endogenous (para)retroviruses (EPRV). There were prominent changes to sRNA profiles in these hybrids involving 22-nt species produced in the DCL2 biogenesis pathway, and the hybridization-induced changes to the gene expression were similar to those in a dcl2 mutant. Conclusions: These findings indicate that hybridization leads to activation of EPRV, perturbation of small RNA profiles, and, consequently, changes in the gene expression. Such hybridization-induced variation in the gene expression could increase the natural phenotypic variation in natural evolution or in breeding for agriculture.
Eisten im Lötschenthal gegen Platten, Ried und Faldungrat
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1860

description: nach Bühlmann ; [Kopie Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Monte Zucchero 2957 : gezeichnet von Schiedo im Val Prato
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1873

description: [Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Cyclocephala vestita Hohne 1923
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala vestita

description: Cyclocephala vestita Höhne, 1923
Cyclocephala vestita Höhne 1923b: 359 (Suriname, French Guiana, Brazil, Paraguay)
Distribution. Guyana: Endrödi 1966a: 330, 1985a: 75, 139; Moore et al. 2018b: 261. Suriname: Höhne 1923b: 359; Endrödi 1966a: 330, 1985a: 75, 139; Moore et al. 2018b: 261; MHCN. French Guiana: Höhne 1923b: 359; Duranton 2011: 16; Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 261. “Guianas”: Arrow 1937b: 17; Blackwelder 1944: 253. Brazil: Höhne 1923b: 359; Arrow 1937b: 17; Blackwelder 1944: 253; Endrödi 1966a: 330, 1985a: 75, 139; Moore et al. 2018b: 261. Other: Höhne 1923b: 359 (Paraguay); Endrödi 1966a: 330 (Paraguay), 1985a: 75, 139 (Paraguay); Moore et al. 2018b: 261 (Paraguay).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 186, DOI: 10.5281/zenodo.3678492
Schwarzsee bey Zermatt
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1860

description: nach Bühlmann ; [Kopie Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
St. Nicolaus Capelle am Weg zum Rhonegletscher
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1860

description: nach Bühlmann ; [Kopie Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: in silico modelling, formulation, characterisation, and in vitro studies
Creators: name: Sid, Dounia
name: Baitiche, Milad
name: Elbahri, Zineb
name: Djerboua, Ferhat
name: Boutahala, Mokhtar
name: Bouaziz, Zouhair
name: Le Borgne, Marc
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: The aim of this study was to prepare and characterise inclusion complexes of a low water-soluble drug, mefenamic acid (MA), with β-cyclodextrin (β-CD). First, the phase solubility diagram of MA in β-CD was drawn from 0 to 21 × 10−3 M of β-CD concentration. A job’s plot experiment was used to determine the stoichiometry of the MA:β-CD complex (2:1). The stability of this complex was confirmed by molecular modelling simulation. Three methods, namely solvent co-evaporation (CE), kneading (KN), and physical mixture (PM), were used to prepare the (2:1) MA:β-CD complexes. All complexes were fully characterised. The drug dissolution tests were established in simulated liquid gastric and the MA water solubility at pH 1.2 from complexes was significantly improved. The mechanism of MA released from the β-CD complexes was illustrated through a mathematical treatment. Finally, two in vitro experiments confirmed the interest to use a (2:1) MA:β-CD complex.
Additional file 3 of Differential susceptibility of Onchocerca volvulus microfilaria to ivermectin in two areas of contrasting history of mass drug administration in Cameroon: relevance of microscopy and molecular techniques for the monitoring of skin microfilarial repopulation within six months of direct observed treatment
Creators: name: Abong, Raphael Awah
name: Glory N. Amambo
name: Ndongmo, Patrick W. Chounna
name: Njouendou, Abdel Jelil
name: Ritter Manuel
name: Amuam Andrew Beng
name: Esum, Mathias Eyong
name: Kebede Deribe
name: Fru-Cho, Jerome
name: Fombad, Fanny F.
name: Nji, Theobald Mue
name: Enyong, Peter Ivo
name: Poole, Catherine B.
name: Pfarr, Kenneth
name: Hoerauf, Achim
name: Carlow, Clotilde K. S.
name: Wanji, Samuel
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 3 S3 Fig Representative data for a 45-cycle reaction for the duplex real-time PCR assay showing positive (above threshold level indicated by the red horizontal line) and negative (below threshold level) signals.
Analyzing Large Language Models For Classifying Sexual Harassment Stories With Out-of-Vocabulary Word Substitution
Creators: name: Paik, Seung Yeon
Publisher: name: Purdue University Graduate School
Year: 2024
Subjects: classificationCode: 460208
subject: Natural language processing
classificationCode: 440204
subject: Crime and social justice

description: Sexual harassment is regarded as a serious issue in society, with a particularly negative impact on young children and adolescents. Online sexual harassment has recently gained prominence as a significant number of communications have taken place online. Online sexual harassment can happen anywhere in the world because of the global nature of the internet, which transcends geographical barriers and allows people to communicate electronically. Online sexual harassment can occur in a wide variety of environments such as through work mail or chat apps in the workplace, on social media, in online communities, and in games (Chawki & El Shazly, 2013).
However, especially for non-native English speakers, due to cultural differences and language barriers, may vary in their understanding or interpretation of text-based sexual harassment (Welsh, Carr, MacQuarrie, & Huntley, 2006). To bridge this gap, previous studies have proposed large language models to detect and classify online sexual harassment, prompting a need to explore how language models comprehend the nuanced aspects of sexual harassment data. Prior to exploring the role of language models, it is critical to recognize the current gaps in knowledge that these models could potentially address in order to comprehend and interpret the complex nature of sexual harassment.
The Large Language Model (LLM) has attracted significant attention recently due to its exceptional performance on a broad spectrum of tasks. However, these models are characterized by being very sensitive to input data (Fujita et al., 2022; Wei, Wang, et al., 2022). Thus, the purpose of this study is to examine how various LLMs interpret data that falls under the domain of sexual harassment and how they comprehend it after replacing Out-of-Vocabulary words.
This research examines the impact of Out-of-Vocabulary words on the performance of LLMs in classifying sexual harassment behaviors in text. The study compares the story classification abilities of cutting-edge LLM, before and after the replacement of Out-of-Vocabulary words. Through this investigation, the study provides insights into the flexibility and contextual awareness of LLMs when managing delicate narratives in the context of sexual harassment stories as well as raises awareness of sensitive social issues.
Auf der Alpweide Tredeil ob Grengiols gegen das Binnenthal
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1860

description: nach Bühlmann ; [Kopie Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Oberhalb Visperterminen gegen Weisshorn und Matterhorn
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1860
Subjects: Wallis

description: Cop nach Bühlmann ; [Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Long-term and short-term patients' barriers to communication
Creators: name: Davis, Carol Elizabeth Egli
Publisher: name: University of Utah
Year: 2012

description: The purpose of the present study was to determine: (1) if long term patients would express more barriers to communications with registered nurses than short-term patients, and (2) if the type and relative frequency of communications barriers between long-term patients and short-term patients was different.  The reason for these questions was that it appeared from previous observations that patients' attitudes changed as the length of hospital stay increased.  The patient is the most important person in the hospital setting, so his perception of the quality of nursing care he received and his total well-being are important criteria by which to judge the effectiveness of nursing care, and in turn may serve to point out strengths and weaknesses in the educational program of the nurse.
Cyclocephala virgo Dechambre 1999
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala virgo

description: Cyclocephala virgo Dechambre, 1999
Cyclocephala virgo Dechambre 1999: 20 (Brazil)
Distribution. French Guiana: Dechambre 1999: 20; Ponchel 2010b: 171, 2011: 60; Duranton 2011: 16 (?); Dupuis 2016b: 109; Moore et al. 2018b: 262. Brazil: Dechambre 1999: 20; Ponchel 2010b: 171; Moore et al. 2018b: 262.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 186, DOI: 10.5281/zenodo.3678492
Additional file 7 of Differential susceptibility of Onchocerca volvulus microfilaria to ivermectin in two areas of contrasting history of mass drug administration in Cameroon: relevance of microscopy and molecular techniques for the monitoring of skin microfilarial repopulation within six months of direct observed treatment
Creators: name: Abong, Raphael Awah
name: Glory N. Amambo
name: Ndongmo, Patrick W. Chounna
name: Njouendou, Abdel Jelil
name: Ritter Manuel
name: Amuam Andrew Beng
name: Esum, Mathias Eyong
name: Kebede Deribe
name: Fru-Cho, Jerome
name: Fombad, Fanny F.
name: Nji, Theobald Mue
name: Enyong, Peter Ivo
name: Poole, Catherine B.
name: Pfarr, Kenneth
name: Hoerauf, Achim
name: Carlow, Clotilde K. S.
name: Wanji, Samuel
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 7 S3 Table. Socio-demographic characteristics and distribution of participants screened by microscopy in the Melong health district.
Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase–associated RNase H function
Creators: name: Fois, Benedetta
name: Corona, Angela
name: Tramontano, Enzo
name: Distinto, Simona
name: Maccioni, Elias
name: Meleddu, Rita
name: Caboni, Pierluigi
name: Floris, Costantino
name: Cottiglia, Filippo
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 60506 Virology
subject: FOS: Biological sciences

description: Bioassay-guided fractionation of the ethyl acetate extract from Teucrium flavum subsp. glaucum, endowed with inhibitory activity towards the HIV-1 reverse transcriptase–associated RNase H function, led to the isolation of salvigenin (1), cirsimaritin (2) and cirsiliol (3) along with the neo-clerodanes teuflavin (4) and teuflavoside (5). Acid hydrolysis of the inactive teuflavoside provided three undescribed neo-clerodanes, flavuglaucins A-C (7-9) and one known neo-clerodane (10). Among all neo-clerodanes, flavuglaucin B showed the highest inhibitory activity towards RNase H function with a IC50 value of 9.1 μM. Molecular modelling and site-directed mutagenesis analysis suggested that flavuglaucin B binds into an allosteric pocket close to RNase H catalytic site. This is the first report of clerodane diterpenoids endowed with anti-reverse transcriptase activity. Neo-clerodanes represent a valid scaffold for the development of a new class of HIV-1 RNase H inhibitors.
Detection and analysis of soft nanoparticles by the resistive pulse method
Creators: name: Holden, Deric Avery
Publisher: name: University of Utah
Year: 2012
Subjects: Soft nanoparticles
Resistive pulse
Microgels
Permeation
Translocation
Porous biological membranes

description: Soft nanoparticles have become increasingly important to the scientific and medical communities particularly in drug delivery systems due to their ability to deliver drugs in a time-dependent or site-specific manner. However, much is left unexplored in their permeation and translocation through porous biological membranes, such as those found in the body. This dissertation presents investigations of the resistive-pulse detection and analysis of soft nanoparticles including microgels and liposomes, using conical nanopores embedded in glass membranes. This analysis provides a first look at the permeation and translocation of soft nanoparticles through a porous membrane. Chapter 1 overviews nanoparticles and their uses in the scientific and medical communities, as well as the resistive-pulse technique and the glass nanopore membrane. Chapter 2 describes investigations on the pressure dependent deformation and translocation of 570 nm radius pNIPAm-AAc microgels through small conical nanopores in glass membranes using the resistive-pulse technique. Translocation event rates, durations, and current pulse heights are found to be a function of the relative conductivities of the microgel and the electrolyte solution. Also, a statistical analysis technique is used to determine the probability of coincident events.
Alcohol as a topic for consideration in prenatal education: nursing intervention implications.
Creators: name: Jefferson, Phyllis Eileen Paul
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Nursing
subject: FOS: Health sciences
subject: Prenatal Care

description: The Fetal Alcohol Syndrome (FAS) is a serious health problem in today's society.  Literature available dating from the time of Aristotle identified the health problem.  Recognition of the severity of this problem has only developed since the 1970's.  Research is now looking into the various aspects of FAS but the problem is complex.  The simplistic component of FAS is that the causative factor in known and is preventable.  Alcohol consumption during pregnancy results in FAS.  Researchers and authorities in the field of FAS advocate prevention of the condition via education.  This study was undertaken to consider the prenatal class as an educational opportunity for learning about alcohol and pregnancy and to determine the knowledge base of expectant parents prior to prenatal education.  Components of education and the demographic data and the instruments utilized n the study were based on the PRECEDE conceptual framework.  PRECEDE is the acronym for predisposing, reinforcing, enabling causes in educational diagnoses, and evaluation adapted from the health belief model.  The design of the research study was descriptive and cross-sectional.  The sample population included prenatal instructors and expectant parents from regions of the Midwest and Intermountain United States.  Instruments utilized to obtain data were developed by the investigator.  The tools used in the study included specific questionnaires for prenatal instructors and expectant parents, a scale to measure the degree of content presented in prenatal classes pertinent to alcohol use during pregnancy, and a true-false test to determine the knowledge base of expectant parents regarding use of alcohol during pregnancy.  Findings from the study indicated that alcohol is a topic of discussion in prenatal education classes.  Varying degrees of the topic of alcohol were discussed by the different prenatal instructors.  The scores on the test for knowledge about alcohol in pregnancy were high in the sample studied. The reason for the high scores can be attributed to multiple factors:  information regarding alcohol during pregnancy is available now through television, pamphlets, and various community and health resources.  Several variables were considered in the design to determine if there were any correlations between the dependent variable of test scores and the independent variables.  The expectant parents scored congruently high.  No other factors were found to be significant.  Nursing implications addressed the importance of prevention through education.  Pregnancy should be avoided if alcoholic used; use of alcohol should be avoided before and during pregnancy.  Other nursing implication and applications to the nurse practitioner role were discussed.  Recommendations for further research were also included.
Im Nicolai Thal vom Hanig
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1860
Subjects: Wallis

description: nach Bühlmann ; [Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Ob Visperterminen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1860
Subjects: Wallis

description: Copie nach Bühlmann ; [Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Additional file 1 of Differential susceptibility of Onchocerca volvulus microfilaria to ivermectin in two areas of contrasting history of mass drug administration in Cameroon: relevance of microscopy and molecular techniques for the monitoring of skin microfilarial repopulation within six months of direct observed treatment
Creators: name: Abong, Raphael Awah
name: Glory N. Amambo
name: Ndongmo, Patrick W. Chounna
name: Njouendou, Abdel Jelil
name: Ritter Manuel
name: Amuam Andrew Beng
name: Esum, Mathias Eyong
name: Kebede Deribe
name: Fru-Cho, Jerome
name: Fombad, Fanny F.
name: Nji, Theobald Mue
name: Enyong, Peter Ivo
name: Poole, Catherine B.
name: Pfarr, Kenneth
name: Hoerauf, Achim
name: Carlow, Clotilde K. S.
name: Wanji, Samuel
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1 S1 Fig Check for inhibitory factors in DNA.
The translocator protein ligands as mitochondrial functional modulators for the potential anti-Alzheimer agents
Creators: name: Kim, TaeHun
name: Morshed, Mohammad N.
name: Londhe, Ashwini M.
name: Lim, Ji W.
name: Lee, Ha E.
name: Cho, Suengmok
name: Cho, Sung J.
name: Hwang, Hayoung
name: Lim, Sang M.
name: Lee, Jae Y.
name: Lee, Jiyoun
name: Pae, Ae N.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Small molecule modulators of mitochondrial function have been attracted much attention in recent years due to their potential therapeutic applications for neurodegenerative diseases. The mitochondrial translocator protein (TSPO) is a promising target for such compounds, given its involvement in the formation of the mitochondrial permeability transition pore in response to mitochondrial stress. In this study, we performed a ligand-based pharmacophore design and virtual screening, and identified a potent hit compound, 7 (VH34) as a TSPO ligand. After validating its biological activity against amyloid-β (Aβ) induced mitochondrial dysfunction and in acute and transgenic Alzheimer’s disease (AD) model mice, we developed a library of analogs, and we found two most active compounds, 31 and 44, which restored the mitochondrial membrane potential, ATP production, and cell viability under Aβ-induced mitochondrial toxicity. These compounds recovered learning and memory function in acute AD model mice with improved pharmacokinetic properties.
Cyclocephala weidneri Endrodi 1964
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala weidneri

description: § Cyclocephala weidneri Endrödi, 1964
Cyclocephala weidneri Endrödi 1964: 462 (Mexico)
Distribution. French Guiana: Duranton 2011: 16 (?). Brazil: Endrödi 1966a: 336, 1985a: 97, 137;
Ratcliffe et al. 2013: 235; Moore et al. 2018b: 263. Venezuela: Endrödi 1964: 462; Endrödi 1966a: 336; Moore et al. 2018b: 263. Other: Endrödi 1964: 462 (Colombia, Ecuador, Mexico, Panama), 1966a: 336 (Colombia, Ecuador, Guatemala, Honduras, Mexico, Panama, Peru), 1985a: 97, 137 (Brazil–Mexico); Ponchel 2011 (not mentioned); Ratcliffe et al. 2013: 235 (Brazil–Mexico); Dupuis 2016b (not mentioned); Moore et al. 2018b: 263 (Colombia, Costa Rica, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Panama, Peru).
Note. Duranton (2011: 13) notes he saw no definite specimens of Cyclocephala weidneri from French Guiana. The species is not mentioned by Ponchel (2011) and Dupuis (2016b) and we have not found any records for the research area. Its distribution appears to be limited to Central America and western South America.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on pages 186-187, DOI: 10.5281/zenodo.3678492
Evaluation of coated titanium anodes
Creators: name: Bagri, Prashant
Publisher: name: University of Utah
Year: 2012
Subjects: Coated titanium anodes
Effect of coating thickness
Effect of metal substrat

description: Coated Titanium Anodes (CTAs) first invented by H. Beer in the 1950s have become standard technology for many electrolysis industries. They consist of precious metal and other oxides coated on a valve metal substrate. As the name suggests, these anodes use titanium as the metal substrate. IrO2 - Ta2O5 binary coatings are used for oxygen evolution systems. In recent years, with increasing concerns about energy consumption in hydrometallurgical processing, there is an ongoing attempt to use these anodes for copper electrowinning. As compared to lead anodes currently used, CTAs reduce the oxygen evolution overpotential, resulting in energy saving. They also eliminate lead sludge giving superior copper cathode deposits. Additionally, the workforce is not exposed to the harmful effects of lead. For this work, anodes with IrO2 - Ta2O5 coatings were prepared in the laboratory having the same total coating loading but varying the number of layers by changing the speed of withdrawal in dip coating. A second set of CTAs were fabricated on niobium, Ti Grade 1, Ti Grade 7 and Ti Grade 36 metal substrates. All the anodes prepared in the laboratory were characterized using standard electrochemical techniques and also subjected to accelerated life testing. Finally the anodes prepared in the laboratory were compared to commercially available industrial anodes. The laboratory produced anodes were found to be superior to the commercial anodes in terms of lifetime per weight of coating loading. This improvement was not the result of the variables examined which had minimal effect on anode performance.
Dent Blanche und Ferpecle Gletscher : Val ' Herens
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1860
Subjects: Gletscher

description: Copie nach Bühlmann ; [Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Compact form fitting small antennas using three-dimensional rapid prototyping
Creators: name: Willis, Bryan Jon
Publisher: name: University of Utah
Year: 2012
Subjects: Small Antennas
Three-dimensional rapid prototyping

description: Three-dimensional (3D) rapid prototyping holds significant promise for future antenna designs. Many complex designs that would be unmanufacturable or costly are realizable on a 3D printing machine. The ability to create 3D designs of virtually any configuration makes it possible to build compact antennas that can form fit to any space. These antennas build on the concept that small antennas can best reach the ideal operating limit when utilizing the entire 3D space in a sphere surrounding the antenna. Antennas require a combination of dielectric and conductive materials. 3D rapid prototyping is already well advanced for plastics and dielectric materials (with more options coming online). Prototyping with conductive materials has lagged behind; due mainly to their higher melting points, but this is advancing as well. This dissertation focuses on 3D rapid prototyping for antenna design. A 3D antenna made from small cubical cells is optimized for 2.4-3GHz using a genetic algorithm (GA). The antennas are built using 3D printing of plastic covered by conductive paint. The effects of the conductivity of the paint and number of layers on the resonance and gain of the antenna are evaluated. These results demonstrate the feasibility of using 3D rapid prototyping for antenna design.
Bey Ferden im Lötschenthal gegen Kippel, Wiler, Ried
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1860
Subjects: Gletscher

description: nach Bühlmann ; IM
description: Initialen "IM" in Bleistift unterhalb Titel
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Additional file 8 of Differential susceptibility of Onchocerca volvulus microfilaria to ivermectin in two areas of contrasting history of mass drug administration in Cameroon: relevance of microscopy and molecular techniques for the monitoring of skin microfilarial repopulation within six months of direct observed treatment
Creators: name: Abong, Raphael Awah
name: Glory N. Amambo
name: Ndongmo, Patrick W. Chounna
name: Njouendou, Abdel Jelil
name: Ritter Manuel
name: Amuam Andrew Beng
name: Esum, Mathias Eyong
name: Kebede Deribe
name: Fru-Cho, Jerome
name: Fombad, Fanny F.
name: Nji, Theobald Mue
name: Enyong, Peter Ivo
name: Poole, Catherine B.
name: Pfarr, Kenneth
name: Hoerauf, Achim
name: Carlow, Clotilde K. S.
name: Wanji, Samuel
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 8 S4 Table. Socio-demographic characteristics and distribution of participants that volunteered for the follow up study in the Bafia health district.
Einsideley bey Visperterminen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1860

description: Copie nach Bühlmann ; [Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Coherently controlled spin-dependent charge carrier transitions in organic semiconductors: properties and applications
Creators: name: Baker, William J.
Publisher: name: University of Utah
Year: 2012
Subjects: Electrically detected
Magnetic resonance
Organic semiconductor

description: This thesis is focused on the investigation of the fundamental physical nature and potential technical applications of spin-dependent charge carrier recombination in poly[2-methoxy-5-(2'-ethyl-hexyloxy)-1,4-phenylene vinylene (MEH-PPV), a π conjugated polymer which has been utilized as organic thin film semiconductor. Pulsed electrically detected magnetic resonance (pEDMR) spectroscopy was used to observe how coherent spin motion of paramagnetic charge carrier states (so called polarons) control the macroscopic conductivity of thin (∼100nm) MEH-PPV layers under different charge carrier injection regimes. The pEDMR experiments were conducted at frequencies covering almost three orders of magnitude (∼20MHz to ∼10GHz) and at temperatures between ∼5K and ∼300k. The measurements revealed that under balanced bipolar injection, the conductivity of MEH-PPV is influenced at any temperature by the polaron pair (PP) mechanism, a spin-dependent process previously described in the literature. The experiments showed that PPs are weakly exchange-and dipolar-coupled pairs but they are strongly influenced by proton induced hyperfine fields. Electrical detection of coherent polaron-spin motion revealed extraordinary long coherence times (order of μs) at room temperature which could qualify PPs for quantum information applications. The PP mechanism was also demonstrated to work as an extraordinary sensitive (< 50 nT Hz−1/2) organic thin film probe which uses the polarons gyromagnetic ratio γ as magnetic field standard. γ was observed to be independent of temperature, device-current, and -bias, and degradation of the MEH-PPV device. In addition to the PP mechanism, another spin-dependent process previously described in the literature was confirmed to significantly influence conductivity in MEH-PPV: Triplet-exciton polaron recombination.
Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET prediction
Creators: name: Ibrahim, Tarek S.
name: Moustafa, Amr H.
name: Almalki, Ahmad J.
name: Allam, Rasha M.
name: Althagafi, Abdulhamid
name: Md, Shadab
name: Mohamed, Mamdouh F. A.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology

description: Two series of chalcone/aryl carboximidamide hybrids 4a–f and 6a–f were synthesised and evaluated for their inhibitory activity against iNOS and PGE2. The most potent derivatives were further checked for their in vivo anti-inflammatory activity utilising carrageenan-induced rat paw oedema model. Compounds 4c, 4d, 6c and 6d were proved to be the most effective inhibitors of PGE2, LPS-induced NO production, iNOS activity. Moreover, 4c, 4d, 6c and 6d showed significant oedema inhibition ranging from 62.21% to 78.51%, compared to indomethacin (56.27 ± 2.14%) and celecoxib (12.32%). Additionally, 4c, 6a and 6e displayed good COX2 inhibitory activity while 4c, 6a and 6c exhibited the highest 5LOX inhibitory activity. Compounds 4c, 4d, 6c and 6d fit nicely into the pocket of iNOS protein (PDB ID: 1r35) via the important amino acid residues. Prediction of physicochemical parameters exhibited that 4c, 4d, 6c and 6d had acceptable physicochemical parameters and drug-likeness. The results indicated that chalcone/aryl carboximidamides 4c, 4d, 6c and 6d, in particular 4d and 6d, could be used as promising lead candidates as potent anti-inflammatory agents.
Nonadrenergic control of skeletal muscle blood flow in the elderly
Creators: name: Barrett-O'Keefe, Zachary
Publisher: name: University of Utah
Year: 2012
Subjects: Aging
Blood flow
Exercise
Nonadrenergic control
Skeletal muscle blood flow
Elderly

description: The objective of this thesis was to determine the role of nonadrenergic vasoactive substances in the control of blood flow in the elderly. The first study aimed to determine the individual and potentiating effects of the renin-angiotensin-aldosterone (RAAS) and alpha-adrenergic systems on the regulation of blood flow in the young and old. We observed an enhanced maximal reduction in brachial artery blood flow in response to angiotensin-II (ANG-II) in the old compared to the young, which was abolished when the alpha-adrenergic component of the response was pharmacologically eliminated with phentolamine. These data suggest that with healthy aging, the increased ANG-IImediated vasoconstriction may be attributed, in part, to potentiation of alpha-adrenergic vasoconstriction, and indicates that the "cross-talk" between the RAAS and adrenergic systems could be an important therapeutic consideration for hypertension in the elderly. The second study of this project was focused on the role of endogenous endothelin-1 (ET-1) in the regulation of vascular tone at rest and during exercise, with a secondary emphasis on how this pathway is altered with advancing age. The first portion of the second study thus sought to characterize the role of ET-1 on blood flow, arterial blood pressure, and oxygen consumption (VO2) during knee extensor exercise in young, healthy adults. This study documented an increase in exercising limb blood flow following ET-1 receptor subtype A (ETA) antagonism (BQ-123), which was accompanied by a decrement in arterial blood pressure and an increase in VO2. Together, these findings have identified a significant role of the ET-1 pathway in the cardiovascular response to exercise, implicating vasoconstriction via the ETA receptor as an important mechanism for both restraint of blood flow in the exercising limb and support of arterial blood pressure in healthy, young adults. During the aging portion of the second study, at rest, blood flow was reduced by 30% in the elderly compared to the young. ETA antagonism did not change resting blood flow in the young, but restored blood flow in the old to a level similar to that of the young. During exercise, BQ-123 increased blood flow and VO2 to a similar degree in both the young and old. Likewise, the increase in arterial blood pressure during exercise was attenuated in a similar manner between groups after BQ-123 administration. Together these findings demonstrate differences in the regulatory role of the ET-1 pathway at rest and exercise with advancing age. Collectively, these studies have provided insight into the role of nonadrenergic vasoactive substances, specifically ANG-II and ET-1, in the regulation of vascular tone with age. Findings from these studies may provide new information concerning the prevention and treatment of ageassociated cardiovascular diseases.
Dyscinetus Harold 1869
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Dyscinetus

description: DYSCINETUS Harold, 1869
Dyscinetus Harold 1869b: 123
Synopsis. Joly and Escalona 2010 (Venezuela)
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 187, DOI: 10.5281/zenodo.3678492
Additional file 4 of Differential susceptibility of Onchocerca volvulus microfilaria to ivermectin in two areas of contrasting history of mass drug administration in Cameroon: relevance of microscopy and molecular techniques for the monitoring of skin microfilarial repopulation within six months of direct observed treatment
Creators: name: Abong, Raphael Awah
name: Glory N. Amambo
name: Ndongmo, Patrick W. Chounna
name: Njouendou, Abdel Jelil
name: Ritter Manuel
name: Amuam Andrew Beng
name: Esum, Mathias Eyong
name: Kebede Deribe
name: Fru-Cho, Jerome
name: Fombad, Fanny F.
name: Nji, Theobald Mue
name: Enyong, Peter Ivo
name: Poole, Catherine B.
name: Pfarr, Kenneth
name: Hoerauf, Achim
name: Carlow, Clotilde K. S.
name: Wanji, Samuel
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 4 S4 Fig. A. Representative Data obtained from individual samples using a colorimetric LAMP assay. Samples containing O. volvulus microfilariae turned yellow (+) and were scored positive. Negative skin snips samples remained pink (−). B. Specificity of colorimetric LAMP assay. Reactions contained no template DNA (>) or DNA from Onchocerca volvulus (OV), Mansonella perstans (MP) or L. loa (LL).
Oberhalb Visperterminen gegen das Nesthorn
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1860

description: Copie nach Bühlmann ; [Johann Müller-Wegmann]
description: Am oberen Blattrand Bezeichnung "Nesthorn" mit Bleistift eingeklammert und als Bietschorne bezeichnet und unterhalb des Titels Initialen "IM" ergänzt
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
title: Characterization of Sand and Sand-Binder Systems from the Foundry Industry with Electrical Impedance Spectroscopy
Creators: name: Bifano, Luca
name: Fischerauer, Alice
name: Liedtke, Alfred
name: Fischerauer, Gerhard
Publisher: name: University of Bayreuth
Year: 2021
Subjects: subject: 620

description: The global economy consumes an estimated 4×10^10 t of sand per year, with only 2×10^10 t of sand being reproduced by natural sedimentation (Götze and Göbbels, 2017; Peduzzi, 2014). Among other things, sand is also used as a basic material for the production of molds and cores in the foundry industry. The consumption and the economic as well as ecological savings' potential in this area of application can be appreciated by way of an example: the environmental certificate of a single, albeit big German foundry (5160 employees) can be consulted, which states that 39 820 t of sand for casting molds had to be purchased in 2017 (Denes, 2018). In order to avoid having to dispose of the used sand in landfills and to reduce the use of new sand, it is therefore advantageous to renew the used sand in a so-called regeneration process and reuse it as a substitute for new sand in the production of molds and cores. It would be very advantageous if the condition of molding materials (sand–binder systems) in regenerator units could be monitored in real time because of the economic and ecological advantages of a monitored and optimized regeneration process. This work presents the results of investigations in this direction. The objects of investigation in this work are typical molding materials in the foundry industry, e.g., quartz sand, chromite sand, and bentonite as a binder, which are measured impedimetrically with the help of a plate capacitor measuring cell which is connected to an LCR meter (Agilent E4980A). The impedance of the filled capacitor is measured in a frequency range from 1.2 kHz to 1 MHz, containing 123 frequency points. The aim of this research is to work out if the mentioned substances can be measured with the presented measuring method and classified on the basis of impedance characteristics and thus whether impedance spectroscopy can be considered for process monitoring in the molding industry. It is shown that the condition monitoring can possibly be based on impedance spectroscopy because the resulting curves are characteristic of the material used. New and used sands as well as two-component mixtures of sands and binders showed a systematic behavior, which allows the sand or the composition of the mixture to be identified (classified) in the future. The examination of the scatter of the measurement results shows that the impedance data obtained with this method can be measured reproducibly. A descriptive model for multi-component systems is developed in order to be able to interpret the impedance scatter results and their representation in Nyquist plots. From this model, the filling density of the measurement cell and the density of conduction paths can be extracted as essential influence quantities.