cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Potentializing Wellness through the Stories of Female Survivors and Descendants of Indian Residential School Survivors: A Grounded Theory Study
Creators: name: Stirbys, Cynthia Darlene
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Indigenous women
Indian residential schools
historical trauma
gender
mental health
grounded theory
models of wellness
Indigenous ways of knowing
Two-eyed seeing

description: The Indian residential school (IRS) system is part of Canada’s colonial history; an estimated 150,000 First Nations, Inuit, and Métis children attended IRS (Stout & Peters, 2011). Informed by Indigenous principles of respect, relevance, responsibility, reciprocity, and relationality (Deloria, 2004; Ermine 1995; Kirkness & Barnhardt, 2001; Wilson, 2008), this study uses classic grounded theory to explore how female IRS survivors or their female descendants are coping with the intergenerational transmission of trauma. Specifically, the general method of comparative analysis was used to generate theory and identify categories and conceptualizations. The emergent problem found that individual survivors and their descendants were dealing with kakwatakih-nipowatisiw, a Cree term used to identify learned colonial (sick) behaviours. These behaviours manifested first among the administrative staff of the schools, then eventually emerged as female generational violence between, for example, mothers and daughters. Indigenous women in this study aimed to resolve this, their ‘main concern’, in order to strengthen familial relations, especially between female family members. Analysis resulted in the identification of a theory derived from the social process of potentializing wellness, which was grounded in the real-world experiences of Indigenous women. Potentializing wellness involves three dimensions: building personal competencies, moral compassing, and fostering virtues. It was revealed that Indigenous women perceive the ongoing generational effects of IRS differently, and as a result, three behavioural typologies emerged: living the norm, between the norm, and escaping the norm. The “norm” refers to the belief that violence is accepted as a normal part of family life. The paradox, of course, is that this type of behaviour is not normal and Indigenous women in this study are looking for ways to eliminate aggressive behaviours between women. The discoveries made in this research, coupled with the final integrative literature review, suggest that Indigenous People’s cultural ways of knowing have a holistic component that addresses all wellness levels. Effective strategies to deal with intergenerational trauma can emerge when holistic health is followed by, or happens concordantly with, reclaiming cultural norms grounded in community and spiritual life. Indigenizing a Western intervention is not enough. Focusing on the spiritual as well as emotional, physical, intellectual, and social aspects of self is seemingly the best approach for Indigenous People who are dealing with the intergenerational effects of trauma.
Width of vegetated buffer strips to protect aquatic life from pesticide effects
Creators: name: Liebmann, Liana
name: Vormeier, Philipp
name: Weisner, Oliver
name: Liess, Matthias
Publisher: name: My University
Year: 2023
Subjects: Landwirtschaftliche Bewässerung
Schädlingsbekämpfungsmittel
Vegetation
Wasserorganismen
Ökologie
Bundesrepublik Deutschland

description: Vegetated buffer strips (VBS) are an effective measure to retain pesticide inputs during rain events. Numerous studies have examined the retention effects of VBS onpesticides. However, no study has addressed on a large scale with event-related peak concentrations how wide the VBS should be to avoid ecological impacts onaquatic life. Here, we investigated for 115 lowland stream sections in Germany the relevance of environmental and physico-chemical parameters to determine the in-stream pesticide concentration and their ecological risks. Based on peak concentrations related to rain events with precipitation amount resulting in VBS relevantsurface runoff for 30 of the 115 investigated stream sections (25 to 70 mm/d), we demonstrated that the average width of VBS was the main parameter (R2 = 0.38)reducing the pesticide input ratio, indicating a relevant proportion of surface runoff contributing to the total in-stream pesticide concentrations. Additionally, dryditches within agricultural fields increased pesticide input (R2 = 0.31). Generally, substances classified as slightly mobile were better retained by VBS than mobilesubstances. Other factors including slope, land use and vegetation cover of VBS had only a minor influence. We assessed the ecological risk of in-stream pesticideconcentrations by quantifying exceedances of regulatory- (RAC) and field-validated acceptable concentrations (ACfield). We then translated this ecological risk intoprotective VBS width by calculating the quotient of in-stream concentration and threshold (RQ). We estimate that a VBS width of 18 m is sufficient to meet theRQACfield protection goal for 95% of streams. The presence of dry ditches increased the protective VBS width to 32 m. In current agricultural practice, however, 26%of the water stretches investigated do not comply with the prescribed 5 m VBS. An extension of the VBS area to 18 m would demand 3.8% of agricultural land withinthe catchments. A 50% reduction in pesticide use, as required by the European green deal, would still result in 39% (RAC) and 68% (ACfield) of event-related samplesbeing exceeded. Consequently, we see the extension of the VBS width as the most efficient mearsure to sustainably reduce pesticide concentrations in small streams. © 2023 Elsevier
Application of a conceptual model for capacity building in public health nutrition practice
Creators: name: Baillie, Elizabeth
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2010
Subjects: capacity building
public health nutrition
practice

description: Public health nutrition as a field of practice and workforce development has progressed rapidly over the past decade in a number of countries, including Australia. There has been a recent emphasis on increasing the size of the public health nutritionworkforce, but there has been an insufficient focus on the nature of practice and the effectiveness of the public health nutrition workforce. To date, capacity building has not played a significant role in public health nutrition practice, despite capacity building being identified as a critical core function of the public health nutrition workforce. Capacity building efforts thus far have been largely invisible and there has been little recognition of capacity building as a public health strategy in its own right. This thesis used a mixed-method study design involving three investigative stages to investigate capacity building in the specific context of public health nutrition practice to: 1. Conceptualise capacity building in a public health nutrition practice context; 2. Refine this conceptual framework based on consensus development amongst practitioner experts; and 3. Apply the conceptual framework in public health nutrition practice.
Evaluation of Factors Influencing Engagement in Physical Activity in Women during the Transition to Menopause
Creators: name: McArthur, Deanne M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Menopause
Physical Activity
body weight changes for perimenopausal women
Women and physical activity

description: Objective: To explore the informational and behavioural factors, that affect women’s participation in physical activity (PA) and body weight changes during perimenopause. Methods: An environmental scan of online health websites to determine availability and quality of information for women about body weight changes during transition to menopause. An interpretive descriptive qualitative study of women age 40 – 60 to explore factors influencing their PA. Descriptive and inductive qualitative analysis were used. Results: Six of 52 websites (11.5%) contained information specific to perimenopausal women, with one site citing evidence. For 26 women interviewed, the most common enabling factors were daily structure, positive feelings, and accountability; while common barriers were disruptions in daily structure, competing demands, and self - sacrifice. Conclusions: There is a lack of information regarding body weight changes for perimenopausal women. Perimenopausal women attribute their PA participation to psychosocial factors, and not the physiology of menopause.
Neutrophil rheology and transit through capillaries and sinusoids
Creators: name: Doerschuk, C.M.
Publisher: name: American Lung Association
Year: 1999

description: In normal lungs, the concentration of neutrophils within the pulmonary capillary blood is about 40–80 times higher than it is within the blood in large vessels (1). This increased concentration, often referred to as the marginated pool, is thought to play an important role in host defense by allowing neutrophils time to sniff the local environment, looking for evidence of organisms or other stimuli that have escaped the initial barriers of host defense. The increased concentration is due to the difference in the pulmonary capillary transit times of neutrophils compared with erythrocytes (RBCs). Whereas RBC and plasma transit times measure 1–2 s, Lien and Wagner have shown that the median transit time of neutrophils is 26 s, with a wide range of 2 to more than 1,200 s (2, 3). Neutrophils are not simply moving more slowly than RBCs; rather, they travel in hops through the highly anastomosing network of pulmonary capillary segments, with pauses followed by rapid travel. These observations suggest that a neutrophil moves rapidly through the larger capillary segments, but when it encounters a narrow one, it stops and requires time to deform. While neutrophils appear to elongate quickly when only small changes in shape are needed to enter a segment, deformation for entry into segments with diameters less than about 5.3 mm requires a delay (4). This deformation time likely accounts for the longer transit times of neutrophils than RBCs and for the formation of the marginated pool. The large contribution of the deformation time to the total transit time points out the importance of the biomechanical properties of neutrophils, particularly their ability to deform, in the flow of these cells through the pulmonary capillary bed on the path from an arteriole to a venule.
Delimitation of maritime boundary between Vietnam and China in the Gulf of Tonkin.
Creators: name: Huang, Dongdong.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Geography.

description: This dissertation begins with a general description of facts, both physical and non-physical, on the dispute in the Gulf of Tonkin. The context in which the dispute arose is given first so that the reader can understand the background of the dispute in terms of both its regional setting (the South China Sea region) and its place in the overall bilateral disputes between Vietnam and China. Next, the physical aspects of the dispute, including coastal configuration, islands, resources, and geomorphological and geological conditions, are described. Then the development of the dispute and the positions of the parties are outlined. The second and third parts of the thesis attempt to answer three questions: (1) What rules and principles of international law are applicable to the delimitation of the territorial seas, exclusive economic zone, and continental shelf in the Gulf of Tonkin? (2) Did the 1887 Sino-French Convention establish the maritime boundary between Vietnam and China in the Gulf of Tonkin? (3) What is the course of the single maritime boundary between Vietnam and China in the Gulf of Tonkin from the eastern point of Tra Co to the closing line of the Gulf? In the examination of the applicable law, the rules on maritime delimitation are classified into legal principles, equitable criteria, relevant circumstances, and practical methods. A boundary line is drawn in the Gulf of Tonkin to illustrate the equitableness of the result reached in the research. The delimitation line was divided into three segments. In the first segment (from the land boundary terminus to the mid-point of oppositeness of coastal relationship), the basic criterion of equal division of the overlapping area requires the adoption of the bisector method based on the general direction of the coasts. Given the roughly equal lengths of the respective coasts of the Parties, the bisector line satisfies the equitable requirements. In the second segment, a median line is drawn from the end-point of the bisector line to the closing line of the Gulf of Tonkin so as to reflect the prevailing oppositeness of the coastal relationship. Finally, the presence and size of the Archipelago des Fai Tsi Long are taken into account in the same way as the Bijago Archipelago was in the Guinea--Guinea-Bissau case, that is, as a certain percentage of the length of the coast of Vietnam. (Abstract shortened by UMI.)
L- and P-selectin and CD11/CD18 in intracapillary neutrophil sequestration in rabbit lungs
Creators: name: Kubo, H.
name: Doerschuk, C.M.
name: Doyle, N.A.
name: Graham, L.
name: Bhagwan, S.D.
name: Quinlan, W.M.
Publisher: name: American Lung Association
Year: 1999

description: Infusion of complement fragments induces rapid sequestration of neutrophils within pulmonary capillaries. This study examined the mechanisms through which this sequestration occurs, as well as the effect of complement fragments on the expression of L-selectin and CD11/CD18 using ultrastructural immunohistochemistry. Studies using anti-P-selectin antibodies, fucoidin, L- selectin-depleted neutrophils, and anti-CD18 antibodies showed that selectins and CD18 were not required for neutrophil sequestration. However, maintaining the sequestered neutrophils within the pulmonary capillaries required both L- selectin and CD11/CD18. Neutrophils in the pulmonary capillaries of rabbits given complement fragments expressed 72% less L-selectin and 98% more CD11/CD18 than did those in rabbits given saline. Shedding of L-selectin occurred preferentially from the microvillar processes of the plasma membrane rather than from the fiat intervening regions. About 28% of L-selectin still remained on intracapillary neutrophil membranes after 15 min and was likely available for binding. Shedding of L-selectin appeared slower in vivo than in vitro. These studies indicate that neutrophil sequestration induced by complement fragments requires at least two sequential steps, one that does not require recognized adhesion molecules followed by a second that requires L-selectin and CD11/CD18.
To Sleep, To Dream: Creating diverse representations of depression in speculative fiction for emerging adults
Creators: name: Larkin, Emily
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2018
Subjects: speculative fiction
depression
emerging adults
novel

description: This Doctorate of Creative Arts research examines how speculative fiction written explicitly for an emerging adult audience can represent the personal and diverse nature of depression, a contemporary issue of special significance to this audience, as suicide is the leading cause of death in Australians aged 15-24 (Black Dog Institute 2016: 4). This research is embodied in an original creative artefact, To Sleep, To Dream, a speculative fiction novel that emulates genre conventions such as a dystopian future setting, defamiliarisation, a rebellious heroine, and extrapolations on current technology, to represent depression as a multi-faceted illness that affects individuals in a diversity of ways. The accompanying exegesis explores narrative exemplars including The Hunger Games (Collins 2011), Divergent (Roth 2011), Matched (Condie 2010) and Delirium (Oliver 2011), to understand why speculative fiction conventions may appeal to emerging adults, and how a selection of these may be utilised to reframe understandings of depression among 18-30-year-olds. By exploring the interplay between textual analysis, keeping a practitioner's journal and engaging in creative praxis, the exegesis also documents the practice-led outcomes of writing To Sleep, To Dream, constituting how the research project contributes new knowledge to the field.
title: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 64 Nr. 3 (2022): Mitteilungen des Kunsthistorischen Institutes in Florenz
title: Mitteilungen des Kunsthistorischen Institutes in Florenz
titleType: AlternativeTitle
Creators: name: Mitteilungen Des Kunsthistorischen Institutes In Florenz
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2023

description: Band LXIV (2022), Heft 3
description: Inhalt | Contenuto
Role of CD11b in focal acid-induced pneumonia and contralateral lung injury in rats
Creators: name: Quinlan, W.M.
name: Bree, M.
name: Motosugi, H.
name: Doerschuk, C.M.
Publisher: name: American Thoracic Society
Year: 1998

description: Neutrophil emigration in response to acid aspiration does not require the adhesion complex, CD11/CD18. This study examined the role of CD11b/CD18 using the anti-CD1 lb F(ab')2 1B6, in focal HCl-induced intracapillary neutrophil sequestration and edema formation within rat lungs, as well as the effect of pretreatment with endotoxin on this injury. The results show that at the site of aspiration pneumonia, anti-CD11b F(ab')2 did not inhibit neutrophil sequestration or edema formation, either with or without endotoxin pretreatment. In the contralateral lung, focal HCl aspiration induced neutrophil sequestration that was inhibited by the anti-CD11b F(ab')2 but no edema formation. The combined effect of endotoxin pretreatment and HCl aspiration induced CD11b/CD18-independent edema formation in the contralateral lung. These data indicate that CD11b/CD18-independent pathways mediate neutrophil sequestration and edema formation at that pneumonic site with or without pretreatment with endotoxin. CD11b/CD18 mediates neutrophil sequestration at distant sites when no endotoxin is present, although this CD11b/CD18-dependent sequestration is not association with edema formation. The combined effects of endotoxin and HCl aspiration induce edema formation at distant sites that could not be prevented by inhibiting the function of the CD11b/CD18 prior to aspiration.
Inflammatory cell distribution within and along asthmatic airways
Creators: name: Reilly, J.J.
name: Drazen, J.M.
name: Haley, K.J.
name: Wiggs, B.R.
name: Mentzer, S.J.
name: Doerschuk, C.M.
name: Sugarbaker, D.J.
name: Sunday, M.E.
name: Kozakewich, H.P.
Publisher: name: American Thoracic Society
Year: 1998

description: Asthmatic airways are infiltrated with inflammatory cells that release mediators and cytokines into the microenvironment. In this study, we evaluated the distribution of CD45-positive leukocytes and eosinophils in lung tissue from five patients who died with severe asthma compared with five patients with cystic fibrosis. For morphometric analysis, the airway wall was partitioned into an 'inner' area (between basement membrane and smooth muscle) and an 'outer' area (between smooth muscle and alveolar attachments). Large airways (with a perimeter greater than 3.0 mm) from patients with asthma or cystic fibrosis had a greater density of CD45-positive cells (p < 0.05) and eosinophils (p < 0.001) in the inner airway region compared with the same airway region in small airways. Furthermore, in small airways, asthmatic lungs showed a greater density of CD45-positive cells (p < 0.01) and eosinophils (p < 0.01) in the outer compared with the inner airway wall region. These observations indicate that there are regional variations in inflammatory cell distribution within the airway wall in patients with asthma that are not observed in airways from patients with cystic fibrosis. We speculate that this inflammatory cell density in peripheral airways in severe asthma may relate to the peripheral airway obstruction characteristic of this condition.
Genetic analysis of resistance to hepatopancreatic parvovirus in banana shrimp (Fenneropenaeus merguiensis)
Creators: name: Phuthaworn, Chontida
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2019
Subjects: hepatopancreatic parvovirus
HPV
viral resistance
selective breeding
marker-trait association analysis
pedigree inference
SNP
banana shrimp

description: Aquaculture is one of the world's fastest growing businesses; aquaculture production has continuously increased and currently accounts for more than 44.10% of fisheries production worldwide. Shrimp is one of the world's leading traded fishery products by value, representing 15.30% of the total trade value (US$148 billion) in 2014; banana shrimp (Feneropenaeuse merguensis) is one of the major types of shrimp farmed in Australia, accounting for 30% of the total shrimp production. However, shrimp farming has been facing difficulties from massive losses in production due to viral diseases; to date, routine biosecurity management is still not reliable enough to prevent disease outbreaks from viral infections. One alternative to prevent viral disease outbreaks is selective breeding, which aims to generate shrimp lines that are genetically resistant to viruses.
Photonic band gaps and planar cavity of two-dimensional eightfold symmetric void-channel photonic quasicrystals
Creators: name: Zhou, Guangyong
name: Gu, Min
Publisher: name: Swinburne
Year: 2024

description: By using the femtosecond laser induced microexplosion method, high-quality two-dimensional eightfold photonic quasicrystals have been fabricated in a solid transparent polymer material. Multiorder band gaps have been observed in a 25-layer structure with a suppression rate of up to 72% for the fundamental gap. Polarization measurements show that the photonic quasicrystal has a strong anisotropic effect, showing that the transverse electric is the favorite polarization. Fabry-Pérot cavities have been fabricated by removing the central layer of channels. Based on the cavity mode position, the order of the mode and the effective cavity size have been determined.
Neutrophil margination, sequestration, and emigration in the lungs of L- selectin-deficient mice
Creators: name: Doerschuk, C.M.
name: Meek, B.B.
name: Tedder, T.F.
name: Doyle, N.A.
name: Kutkoski, G.J.
name: Bhagwan, S.D.
name: Steeber, D.A.
Publisher: name: American Society for Clinical Investigation
Year: 1997

description: These studies tested the hypothesis that L-selectin plays a role in neutrophil traffic in the lungs, particularly in neutrophil margination, sequestration, and emigration, using L-selectin-deficient mice. No defect in neutrophil margination within either capillaries or arterioles and venules was observed in uninflamed lungs of L-selectin-deficient mice. The initial rapid sequestration of neutrophils within the pulmonary capillaries 1 rain after intravascular injection of complement fragments was not prevented. In contrast, L-selectin did contribute to the prolonged neutrophil sequestration (≤ 5 min). Interestingly, neutrophil accumulation within noncapillary microvessels required L-selectin at both 1 and 5 min after complement injection. During bacterial pneumonias, L-selectin played a role in neutrophil accumulation within noncapillary microvessels in response to either Escherichia coil or Streptococcus pneumoniae and within capillaries in response to E. coli but not S. pneumoniae. However, L-selectin was not required for emigration of neutrophils or edema in response to either organism. These studies demonstrate a role for L-selectin in the prolonged sequestration of neutrophils in response to intravascular complement fragments, in the intracapillary accumulation of neutrophils during E. coli- induced pneumonia, and in the accumulation of neutrophils within noncapillary microvessels when induced by either intravascular complement fragments or bacteria within the airways.
La mort du XXe siècle dans la Tétralogie du Monstre : postmodernité, posthistoire et posthumain dans l’œuvre d’Enki Bilal
Creators: name: St-Jacques, Marianne
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Enki Bilal
Tétralogie du Monstre
bande dessinée
postmodernité
posthistoire
posthumain
Yougoslavie
Le sommeil du Monstre
32 décembre
Rendez-vous à Paris
Quatre?

description: Bédéiste, cinéaste, scénariste et illustrateur, Enki Bilal est un artiste contemporain de nationalité franco-yougoslave. De 1998 à 2007, celui-ci s’inspire des guerres qui déchirent sa Yougoslavie natale pour rédiger la Tétralogie du Monstre, un cycle de bande dessinée futuriste qui traduit une vision du monde propre aux années 1990-2000. Marquant une rupture dans le parcours de Bilal, cette œuvre propose une projection fictionnelle d’événements correspondant au postmodernisme social anticipé par Jean-François Lyotard et décrit par Jean Baudrillard. Avec cette thèse, nous démontrons comment l’auteur, en s’intéressant aux différents enjeux propres à ces deux décennies, s’engage dans un dialogue avec les grands penseurs de la postmodernité et cherche à représenter les différentes idées de « morts » – fin des grands récits – qui sont au cœur de leurs discours. À l’aide des notions de postmoderne, de posthistoire et de posthumain, nous avons analysé la question de la mort des idéologies politico-religieuses, la mort de la science et la mort de l’art dans l’œuvre de Bilal.
title: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 64 Nr. 2 (2022): Mitteilungen des Kunsthistorischen Institutes in Florenz
title: Mitteilungen des Kunsthistorischen Institutes in Florenz
titleType: AlternativeTitle
Creators: name: Mitteilungen Des Kunsthistorischen Institutes In Florenz
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2023

description: Band LXIV (2022), Heft 2
description: Inhalt | Contenuto
Numerical Computations of Action Potentials for the Heart-torso Coupling Problem
Creators: name: Rioux, Myriam
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Cardiac Electrophysiology
Bidomain model
Heart-torso coupling
Realistic geometries
Level Sets
Numerical Simulations
Finite Element Method
Action potentials
Asymptotic analysis
Mesh adaptation

description: The work developed in this thesis focusses on the electrical activity of the heart, from the modeling of the action potential originating from cardiac cells and propagating through the heart, as well as its electrical manifestation at the body surface. The study is divided in two main parts: modeling the action potential, and numerical simulations. For modeling the action potential a dimensional and asymptotic analysis is done. The key advance in this part of the work is that this analysis gives the steps to reliably control the action potential. It allows predicting the time/space scales and speed of any action potential that is to say the shape of the action potential and its propagation. This can be done as the explicit relations on all the physiological constants are defined precisely. This method facilitates the integrative modeling of a complete human heart with tissue-specific ionic models. It even proves that using a single model for the cardiac action potential is enough in many situations. For efficient numerical simulations, a numerical method for solving the heart-torso coupling problem is explored according to a level set description of the domains. This is done in the perspective of using directly medical images for building computational domains. A finite element method is then developed to manage meshes not adapted to internal interfaces. Finally, an anisotropic adaptive remeshing methods for unstructured finite element meshes is used to efficiently capture propagating action potentials within complex, realistic two dimensional geometries.
Neutrophil emigration in the skin, lungs, and peritoneum: Different requirements for CD11/CD18 revealed by CD18-deficient mice
Creators: name: Mizgerd, J.P.
name: Bhagwan, S.D.
name: Kubo, H.
name: Doerschuk, C.M.
name: Beaudet, A.L.
name: Kutkoski, G.J.
name: Scharffetter-Kochanek, K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: To determine the role of CD11/CD18 complexes in neutrophil emigration, inflammation was induced in the skin, lungs, or peritoneum of mutant mice deficient in CD18 (CD18(-/-) mutants). Peripheral blood of CD18(-/-) mutants contained 11-fold more neutrophils than did blood of wild-type (WT) mice. During irritant dermatitis induced by topical application of croton oil, the number of emigrated neutrophils in histological sections of dermis was 98% less in CD18(-/-) mutants than in WT mice. During Streptococcus pneumoniae pneumonia, neutrophil emigration in CD18(-/-) mutants was not reduced. These data are consistent with expectations based on studies using blocking antibodies to inhibit CD11/CD18 complexes, and on observations of humans lacking CD11/CD18 complexes. The number of emigrated neutrophils in lung sections during Escherichia coli pneumonia, or in peritoneal lavage fluid after 4 h of S. pneumoniae peritonitis, was not reduced in CD18(-/-) mutants, but rather was greater than the WT values (240 ± 30 and 220 ± 30% WT, respectively). Also, there was no inhibition of neutrophil emigration during sterile peritonitis induced by intraperitoneal injection of thioglycollate (90 ± 20% WT). These data contrast with expectations. Whereas CD11/CD18 complexes are essential to the dermal emigration of neutrophils during acute dermatitis, CD18(-/-) mutant mice demonstrate surprising alternative pathways for neutrophil emigration during pneumonia or peritonitis.
Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus
Creators: name: Morgenstern, D.E.
name: Gifford, M.A.C.
name: Doerschuk, C.M.
name: Li, L.L.
name: Dinauer, M.C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Mice with X-linked chronic granulomatous disease (CGD) generated by targeted disruption of the gp91(pbox) subunit of the NADPH-oxidase complex (X-CGD mice) were examined for their response to respiratory challenge with Aspergillus fumigatus. This opportunistic fungal pathogen causes infection in CGD patients due to the deficient generation of neutrophil respiratory burst oxidants important for damaging A. fumigatus hyphae. Alveolar macrophages from X-CGD mice were found to kill A. fumigatus conidia in vitro as effectively as alveolar macrophages from wild-type mice. Pulmonary disease in X-CGD mice was observed after administration of doses ranging from 105 to 48 spores, none of which produced disease in wild-type mice. Higher doses produced a rapidly fatal bronchopneumonia in X-CGD mice, whereas progression of disease was slower at lower doses, with development of chronic inflammatory lesions. Marked differences were also observed in the response of X-CGD mice to the administration of sterilized Aspergillus hyphae into the lung. Within 24 hours of administration, X-CGD mice had significantly higher numbers of alveolar neutrophils and increased expression of the proinflammatory cytokines IL-1β and TNF-α relative to the responses seen in wild-type mice, whereas X-CGD mice developed chronic granulomatous lesions that persisted for at least six weeks. This is the first experimental evidence that chronic inflammation in CGD does not always result from persistent infection, and suggests that the clinical manifestations of this disorder reflect both impaired microbial killing as well as other abnormalities in the inflammatory response in the absence of a respiratory burst.
The role of design in the development of museum exhibitions in Australia
Creators: name: Hewitt, Thomas
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2016
Subjects: interpretive design
museum planning
exhibition development and design

description: This thesis is an investigation into the value of design and the role of the exhibition designer in the development of museum exhibitions in Australia. Five research questions were posed and a combined approach of case studies, interviews, questionnaires, phenomenological analysis and an on-going literature review were adopted in producing this thesis. To address the lack of serious descriptive writing by museum exhibition designers, the views of six noted practicing designers (three in the UK and three in Australia) were sought and three case studies of Australian projects designed by three prominent Australian designers were undertaken. For the first time, a comprehensive look "behind the scenes" of the exhibition design process is presented. There is continuing debate about curatorship, education, electronic technology and social media but very little debate or discussion about exhibition design in museum literature. It is argued in this study that such debate needs to take place and that it will be of significant benefit to museums, designers and the public alike. A surprising, but not unexpected finding revealed in analysing the responses of the design practitioners surveyed in the author's questionnaire, was their suggestion that the introduction of new technology often has little to do with museum exhibition design-unless a particular technology offers an economically viable opportunity to create innovative and unique environments and presentations that offer the public a more effective and engaging experience. The result of the designer's contribution to the success of exhibitions is there for anyone to see in any museum. What is not evident is how that contribution is made and whether it could be better made. While many museum commentators believe that the designer merely provides a decoration service, it is increasingly becoming apparent that museums today understand that the designer's role is one of communicator. This thesis reveals that effective design is integral to the success of any museum exhibition and that, if appropriately employed, the designer fulfils a number of combined roles-as interior architect, graphic designer, industrial designer, furniture designer, display designer, lighting designer, scenographic designer and construction manager-but almost never that of simply a decorator.
Six1 Is Important for Myoblast Proliferation Through Direct Regulation of Ccnd1
Creators: name: Horner, Ellias
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Myoblasts
Satellite Cells
Six1
Proliferation
Myogenesis
Cell Cycle
Ccnd1

description: The transcription factor Six1 of the sine oculis homeobox family has been tied to skeletal muscle formation. Work completed thus far has allowed our research team to identify the precise mechanism by which Six1 regulates the expression of MyoD, a key myogenic gene, in muscle stem cells. Furthermore, loss-of-function of this protein, mediated by RNA interference, has implicated Six1 as essential towards normal myogenic differentiation. However, beyond Six1 and its involvement towards myogenesis, our data also suggests the transcription factor as a potential regulator of the cell cycle. Data from our lab shows that loss of Six1 expression significantly impairs primary myoblast proliferation and appears to impair satellite cell activation in response to muscle injury in vivo. Furthermore, loss of Six1 decreases the expression of key cell cycle genes. Combining functional genomics approaches such as ChIP-Seq and Gene Expression Profiling together with Gene Ontology Term Enrichment shows a significant representation for biological processes regarding the cell cycle and its regulation; these biological clusters contain a large subset of genes that are bound and modulated by Six1. In particular, Ccnd1 was found to display a similar expression pattern as Six1 in growing myoblasts and its expression was found to be directly controlled by Six1. Furthermore, Ccnd1 over-expression was sufficient to rescue the Six1-knockdown associated cell cycle phenotype. Together, these data suggest that in response to injury Six1 enhances the expression of the cell cycle gene Ccnd1 thus modulating myoblast proliferation for muscle regeneration.
Preservation of complement-induced lung injury in mice with deficiency of NADPH oxidase
Creators: name: Kubo, H.
name: Doerschuk, C.M.
name: Quintan, W.M.
name: Morgenstern, D.
name: Ward, P.A.
name: Dinauer, M.C.
Publisher: name: American Society for Clinical Investigation
Year: 1996

description: Mice with chronic granulomatous disease (X-CGD mice) generated by mutating the X-linked gene for a subunit of NADPH oxidase have been analyzed for their ability to respond to intravenous injection of purified cobra venom factor (CVF). This agent in wild-type mice produces a neutrophil-dependent and catalase-sensitive form of lung injury. Lung injury was evaluated by measuring the accumulation of extravascular albumin. Quite unexpectedly, the lungs of X-CGD mice showed no difference in the increased accumulation of extravascular albumin after injection of CVF when compared to wild-type mice. In both X-CGD and wild-type mice, full development of injury required neutrophils. While catalase was highly protective in wild-type mice, its protective effects were completely lost in the X-CGD mice. Furthermore, a competitive antagonist of L-arginine, N(G)-methyl-L-arginine, was protective in X-CGD mice but not in wild-type mice. Allopurinol was protective in both types of mice. Both the basal and the CVF-inducible lung mRNA for inducible nitric oxide synthase and IL-1β was similar in X-CGD and wild-type mice. These data indicate that oxygen radical production and lung injury in response to injection of CVF occurs through alternative pathways in mice with genetic deletion of NADPH oxidase.
Role of the intercellular adhesion molecule-1 (ICAM-1) in endotoxin-induced pneumonia evaluated using ICAM-1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies, and ICAM-1 mutant mice
Creators: name: Sligh, J.
name: Bennett, C.F.
name: Kumasaka, T.
name: Condon, T.P.
name: Doyle, N.A.
name: Takei, F.
name: Doerschuk, C.M.
name: Quinlan, W.M.
name: Beaudet, A.L.
Publisher: name: The American Society for Clinical Investigation
Year: 1996

description: This study examined the effectiveness of antisense oligonucleotides targeted to intercellular adhesion molecule-1 (ICAM-1) to inhibit endotoxin-induced upregulation of ICAM-1 and neutrophil emigration and compared the apparent role of ICAM-1 when examined using antisense oligonucleotides, anti-ICAM-1 antibodies, and ICAM-1 mutant mice. Antisense oligonucleotides inhibited upregulation of ICAM-1 mRNA at 4 and 24 h after instillation of endotoxin in a dose-dependent manner. Neutrophil emigration into the alveolar spaces at 24 h was inhibited by 59%, similar to inhibition using the anti-ICAM-1 antibodies 3E2 (58%) and YN1/ 1 (75%). No inhibition was observed in the ICAM-1 mutant compared to wild-type mice. These data show that antisense oligonucleotides targeted to ICAM-1 inhibit the endotoxin-induced upregulation of ICAM-1 in the lung and are as effective as anti-ICAM-1 antibodies in preventing neutrophil emigration. The incomplete inhibition by either antisense oligonucleotides or antibodies suggests that alternative adhesion pathways that do not require ICAM-1 are important in neutrophil emigration in the lungs. The disparity in the role of ICAM-1 when evaluated using antisense or antibodies compared to mutant mice suggests that either these inhibitors are exerting additional effects on endothelial cells other than blockade of ICAM-1 or mutant mice have upregulated the ICAM-1 - independent pathways to compensate for the long-term loss of ICAM-1.
Désir, honte et dégoût : émotions et relations humaines
Creators: name: Lagacé, Jovanie Christine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Désir
Honte
Dégoût
René Girard
Martha C. Nussbaum
Hannah Arendt
aspect social des émotions
narcotisation de l'identité individuelle

description: Le présent travail propose une réflexion sur l'aspect social des émotions par l'entremise d'un examen de la dimension conflictuelle de 3 émotions: le désir, la honte et le dégoût. L'aspect problématique de ces émotions se situe au niveau de leur hypertrophie, en ce qu'elle encourage une emphase sur le soi, sur l'autosuffisance et la toute-puissance de l'individu, ce qui se traduit par des répercussions interpersonnelles, notamment la réduction marquée de la diversité des relations humaines qu'entretient l'individu avec les autres, et intrapersonnelles, particulièrement la narcotisation de l'identité individuelle. Cette réflexion est animée par la pensée de 3 principaux auteurs: celle de René Girard et de Martha C. Nussbaum afin d'explorer, pour chaque émotion, les implications de leur hypertrophie chez l'individu, puis de l'incidence du contexte social sur l'hypertrophie de ces émotions; celle d'Hannah Arendt afin de mieux comprendre la dynamique des relations humaines et comme palliatif à ces répercussions interpersonnelles et intrapersonnelles.
Exploring molecular technologies to optimise traditional breeding programs in aquaculture: Developing pedigrees using DNA microsatellite and discovering functional genes using genomics
Creators: name: Whatmore, Paul
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2016
Subjects: genetic selection
inbreeding
transcriptomics

description: With increasing global population and peaking production levels for terrestrial agriculture and wild capture fisheries, aquaculture is positioned to meet future seafood demand. However, only an estimated 10% of aquaculture stock are selectively improved, due to technical barriers in implementing effective aquaculture selective breeding programs, such as the inability to physically tag offspring. Molecular technologies provide the means to overcome these technical difficulties and also improve on traditional phenotypic selection, by incorporating genetic data into selection programs. The primary focus of this present study is to develop molecular tools to identify family relationships (pedigree assignment) and genes associated with traits (genetic parameters and functional markers) within aquaculture breeding programs, enabling effective management of genetic resources and optimizing of selection response. In essence this research will drive a necessary shift from mass selection based on phenotypes (the visible appearance of the animal) which currently dominates Australian aquaculture, often without regard to family relationships and inbreeding levels, to one that incorporates selection based on genetic information such as functional markers and information from relatives, while managing genetic diversity and rates of inbreeding.
Anaerobic Digestion of Corn Ethanol Thin Stillage for Biogas Production in Batch and By Downflow Fixed Film Reactor
Creators: name: Wilkinson, Andrea
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Anaerobic Digestion
BMP
Downflow fixed film reactor
Thin stillage

description: Anaerobic digestion (AD) of corn thin stillage (CTS) offers the potential to reduce corn grain ethanol production energy consumption. This thesis focuses on results collected from AD of CTS at mesophilic temperatures in batch and by down-flow fixed film reactor. Experiments conducted include a series of biochemical methane potential (BMP) assays that investigated the digestion of CTS as the sole carbon source at a variety of food-to- microorganism ratios with and without acclimated biomass, under co-digestion conditions and also with the addition of supplemental nutrients. Additional BMP assays were conducted which investigated the potential to reduce fresh water consumption by using of digested effluent for substrate dilution. Continuous studies employed two 28L down-flow stationary fixed film reactors to examine. Chemical oxygen demand and volatile solids removal efficiencies greater than 85% were achieved up to an organic loading rate of 7.4 g TCOD/L/d and hydraulic retention time of 5 days.
Holi-Farben - Spaß mit unbekannten Risiken
Creators: name: Bach, Sabine
name: Becker, Kerstin
name: Bossmann, Katrin
name: Straff, Wolfgang
name: Süring, Katrin
Publisher: name: My University
Year: 2016

description: Holi-Farben finden Verwendung auf sogenannten Holi-Festivals und Colour-Runs, bei denen sich die Teilnehmenden mit verschiedenfarbigen feinstaubhaltigen Farbpulvern bewerfen. Auch außerhalb solcher Veranstaltungen sind die Farbpulver kommerziell erhältlich. Die Pulver bestehen zu unterschiedlichen Anteilen aus Feinstaub. Bei Messungen des Umweltbundesamtes (UBA) wurden Feinstaubanteile (PM10) von bis zu 97 Prozent ermittelt. Hinsichtlich des gesundheitlichen Risikos, welches mit der Exposition gegenüber hohen Holi-Feinstaubkonzentrationen verbunden ist, gibt es noch viele Unklarheiten. In eigenen Untersuchungen stellte das UBA fest, dass solche Farbpulver bestimmte Entzündungsreaktionen in vitro auslösen können, die bei den tatsächlich beobachteten gesundheitlichen Reaktionen gegenüber Holi-Pulver eine Rolle spielen könnten. Der Artikel beleuchtet darüber hinaus verschiedene Aspekte von Holi-Feinstaubexpositionen, die für eine Risikobewertung von Holi-Festivals und Colour-Runs sowie für die allgemeine Verbraucherberatung von Relevanz sein könnten.
Quelle: Holi-Farben - Spaß mit unbekannten Risiken : Holi-Colours - fun without risk? / Katrin Bossmann ... - Ill. In: UMID : Umwelt und Mensch - Informationsdienst ; Umwelt & Gesundheit, Umweltmedizin, Verbraucherschutz. - (2016), H. 1, S. 31
description: Holi-Colours are used at Holi-Festivals and Colour-Runs. At these festivities participants throw colourful powders at each other. Holi-Colours are also commercially available elsewhere. The powders contain considerable to very high amounts of particulate matter (PM10). The highest amount analysed by the German Environment Agency was 97 per cent. Despite the widespread use of Holi colours in recent years across Europe and especially in Germany, not much is known about the risk profile of the high exposures that usually occur at Holi-Festivals. Laboratory investigations showed inflammatory reactions in vitro that might account for some of the reported health effects following the exposure to Holi-Particulate Matter. This article reports on various aspects of Holi-Dust exposures that could be useful for the risk evaluation of Holi-Festivals and Colour-Runs as well as the general consumer advisory services.
Quelle: Holi-Farben - Spaß mit unbekannten Risiken : Holi-Colours - fun without risk? / Katrin Bossmann ... - Ill. In: UMID : Umwelt und Mensch - Informationsdienst ; Umwelt & Gesundheit, Umweltmedizin, Verbraucherschutz. - (2016), H. 1, S. 31