cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
An Alternative Form of Replication Protein A Expressed in Normal Human Tissues Supports DNA Repair
Creators: name: Kowalczykowski, Stephen C.
name: Borgstahl, Gloria E.O.
name: Mason, Aaron C.
name: Reardon, Joyce T.
name: Haring, Stuart J.
name: Wold, Marc S.
name: Carreira, Aura
name: Kemp, Michael G.
name: Sancar, Aziz
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Replication protein A (RPA) is a heterotrimeric protein complex required for a large number of DNA metabolic processes, including DNA replication and repair. An alternative form of RPA (aRPA) has been described in which the RPA2 subunit (the 32-kDa subunit of RPA and product of the RPA2 gene) of canonical RPA is replaced by a homologous subunit, RPA4. The normal function of aRPA is not known; however, previous studies have shown that it does not support DNA replication in vitro or S-phase progression in vivo. In this work, we show that the RPA4 gene is expressed in normal human tissues and that its expression is decreased in cancerous tissues. To determine whether aRPA plays a role in cellular physiology, we investigated its role in DNA repair. aRPA interacted with both Rad52 and Rad51 and stimulated Rad51 strand exchange. We also showed that, by using a reconstituted reaction, aRPA can support the dual incision/excision reaction of nucleotide excision repair. aRPA is less efficient in nucleotide excision repair than canonical RPA, showing reduced interactions with the repair factor XPA and no stimulation of XPF-ERCC1 endonuclease activity. In contrast, aRPA exhibits higher affinity for damaged DNA than canonical RPA, which may explain its ability to substitute for RPA in the excision step of nucleotide excision repair. Our findings provide the first direct evidence for the function of aRPA in human DNA metabolism and support a model for aRPA functioning in chromosome maintenance functions in nonproliferating cells.
title: The importance of diagnostic imaging in diagnosing pulmonary embolism in a patient with therapeutic warfarin dose and the potential role of interventional radiology.
Creators: name: Bond, Andrew
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Lung
subject: Thorax
subject: CT
subject: Contrast agent-intravenous
subject: Diagnostic procedure
subject: Embolism / Thrombosis

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: 1) Although uncommon, emphasis that therapeutic dose warfarin does not exclude a pulmonary embolism. 2) Appreciate the importance of the role of the radiologist in diagnosing pulmonary embolism. 3) Warfarin inefficacy is rare, highlight the need for...
Occurrence of colour abnormalities and morphological aberration in common sole Solea solea (L., 1758) captured from the Aegean Sea
Creators: name: CERİM, Hasan
name: ÇELİK, Murat
name: YAPICI, Sercan
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: Occurrence of malpigmentation, including hypomelanosis and ambicoloration, and morphological abnormality were described in Solea solea caught from the Güllük Bay (South West of Turkey). A single specimen of S. solea was reported showing in the blind side a 60% of the coloration found in the ocular side, which was slightly hypomelanistic.
MINTAQA IQTISODIY-IJTIMOIY SALOHIYATIDAN SAMADALI FOYDALANISH YO'LLARI (FARG'ONA VILOYATI MISOLIDA)
Creators: name: Ro'zmatov, B.Z.
Publisher: name: Zenodo
Year: 2023

description: Maqolada O'zbekistonda shahar ma'muriy tumanlarining sonidagi o'zgarishlar, ularning tashkil qilinishi yoki tugatilishi masalalari ko'rib chiqilgan. Shuningdek, Toshkent shahri tumanlarining ba'zi ijtimoiy-iqtisodiy ko'rsatkichlari tahlil qilingan.
The International Workshop on Wave Hindcasting and Forecasting and the Coastal Hazards Symposium
Creators: name: Breivik, Øyvind
name: Swail, Val
name: Babanin, Alexander
name: Horsburgh, Kevin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: FOS: Physical sciences

description: Following the 13th International Workshop on Wave Hindcasting and Forecasting and 4th Coastal Hazards Symposium in October 2013 in Banff, Canada, a topical collection has appeared in recent issues of Ocean Dynamics. Here we give a brief overview of the history of the conference since its inception in 1986 and of the progress made in the fields of wind-generated ocean waves and the modelling of coastal hazards before we summarize the main results of the papers that have appeared in the topical collection.
title: Diffuse Idiopathic Skeletal Hyperostosis (DISH): Increased prevalence and severity in Pacific Islanders
Creators: name: Doyle, Anthony
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Comparative studies
subject: Plain radiographic studies
subject: Musculoskeletal spine
subject: Bones
subject: Arthritides

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The purpose of this study was to investigate the differing rates of DISH by ethnicity and therebyto confirm or refute the long-standing impression among radiologists and clinicians that DISH is more common among Pacific Islanders than in other...
Free the Globe
Creators: name: Gangui, Alejandro
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics Education (physics.ed-ph)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The parallel globe is an old, very simple and ingenious device that, when systematically employed in astronomy classes, becomes a teaching tool with great potential. Properly oriented according to the local meridian, this instrument allows us to follow the shadows in any region of the Earth that is illuminated by the Sun, as well as offering a clear view of the terminator, the fast-moving grey line that divides the day from the night on our planet. With knowledge of the shadows, it is possible to estimate the latitude of a site and to infer local solar time anywhere in the planet's sunlit hemisphere. Furthermore, by using the parallel globe we may understand simply the existence of regions in which objects sometimes do not cast shadows, and also other regions which, on the contrary, sometimes become "long-shadow" countries. In this work, we first review the device and the basics of its assembly and operation. In the second part, we describe in detail some activities targeted to facilitate its use in the classroom, which our research group has been developing during teacher training workshops.
description: Article in Spanish, PDF document including 14 figures. Published version available at http://cms.iafe.uba.ar/gangui/didaastro/#Publications
Population dynamics of Nannopus palustris (Copepoda, Harpacticoida) in the oligo-mesohaline area of the Gironde estuary (France)
Creators: name: SANTOS, Paulo J. P.
name: SOUZA-SANTOS, Lília P.
name: CASTEL, Jacques
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2003

description: In this study, results are presented concerning the population dynamics of the meiobenthic copepod Nannopus
 palustris in the oligo-mesohaline area of the Gironde estuary, France. Samples were taken weekly during one year (April
 1992 to April 1993). Stage-specific birth and mortality rates were calculated using the Argentesi model. Clutch size,
 percentage of ovigerous females and sex ratio of the Nannopus palustris population showed clear seasonal variations
 strongly related to temperature. Other factors like salinity or chlorophyll-a were also significantly related to these population
 parameters. The development time field data obtained for Nannopus palustris was also significantly related to temperature.
 Fecundity, or egg production rate, and instantaneous birth rate showed strong variations throughout the year. In this study
 specific mortality rates for nauplius, copepodite and adult animals were estimated for the first time for a benthic
 harpacticoid. All models indicate that the nauplius stage suffers higher mortality as compared to copepodite stages or adults.
 Waves or peaks of mortality were detected for all stages and were probably related to the moulting process associated to the
 progression of different abundance pulses. All results indicate that the population increase is not food limited during the
 year, being mainly temperature controlled.
Fermion-parity duality and energy relaxation in interacting open systems
Creators: name: Schulenborg, J.
name: Saptsov, R. B.
name: Haupt, F.
name: Splettstoesser, J.
name: Wegewijs, M. R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the transient heat current out of a confined electron system into a weakly coupled electrode in response to a voltage switch. We show that the decay of the Coulomb interaction energy for this repulsive system exhibits signatures of electron-electron attraction, and is governed by an interaction-independent rate. This can only be understood from a general duality that relates the non-unitary evolution of a quantum system to that of a dual model with inverted energies. Deriving from the fermion-parity superselection postulate, this duality applies to a large class of open systems.
description: 5 pages + 19 pages of Supplementary Material
(4016) William Leckis Ewing MacLean
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 1 of Revascularization outcomes in diabetic patients presenting with acute coronary syndrome with non-ST elevation
Creators: name: Ram, Eilon
name: Fisman, Enrique Z.
name: Tenenbaum, Alexander
name: Iakobishvili, Zaza
name: Peled, Yael
name: Raanani, Ehud
name: Sternik, Leonid
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Science Policy
subject: Hematology
subject: 60506 Virology

description: Additional file 1: Table S1. Early results of the subgroup of NSTEMI patients.
An Anticoagulant RNA Aptamer That Inhibits Proteinase-Cofactor Interactions within Prothrombinase
Creators: name: Krishnaswamy, Sriram
name: Rusconi, Christopher P.
name: Sullenger, Bruce A.
name: Lu, Genmin
name: Layzer, Juliana M.
name: Buddai, Sai K.
name: Monroe, Dougald M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The interaction of factor Xa with factor Va on membranes to form prothrombinase profoundly increases the rate of the proteolytic conversion of prothrombin to thrombin. We present the characterization of an RNA aptamer (RNA11F7t) selected from a combinatorial library based on its ability to bind factor Xa. We show that RNA11F7t inhibits thrombin formation catalyzed by prothrombinase without obscuring the active site of Xa within the enzyme complex. Selective inhibition of protein substrate cleavage arises from the ability of the aptamer to bind to factor Xa and exclude interactions between the proteinase and cofactor within prothrombinase. Competition for enzyme complex assembly results from the binding of RNA11F7t to factor Xa with nanomolar affinity in a Ca2+-dependent interaction. RNA11F7t binds equivalently to the zymogen factor X as well as derivatives lacking γ-carboxyglutamic acid residues. We suggest that the ability of RNA11F7t to compete for the Xa-Va interaction with surprisingly high affinity likely reflects a significant contribution from its ability to indirectly impact regions of Xa that participate in the proteinase-cofactor interaction. Thus, despite the complexity of the macromolecular interactions that underlie the assembly of prothrombinase, efficient inhibition of enzyme complex assembly and thrombin formation can be achieved by tight binding ligands that target factor Xa in a discrete manner.
title: The yield of flow cytometry versus histology in obtaining a pathologic diagnosis for a radiologically abnormal lymph node or nodal mass.
Creators: name: Keown, Gracie
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Lymph nodes
subject: Interventional non-vascular
subject: Haematologic
subject: Percutaneous
subject: CT
subject: Ultrasound
subject: Biopsy
subject: Lymphoma
subject: Tissue characterisation

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Background: Flow cytometry is used as an adjunct to histopathologyto diagnose or exclude lymphoma. In particular, it is of great usein the differentiation of a reactive lymph node from a low-grade lymphoma by assessment ofclonality. Flow cytometry...
Additional file 2 of Revascularization outcomes in diabetic patients presenting with acute coronary syndrome with non-ST elevation
Creators: name: Ram, Eilon
name: Fisman, Enrique Z.
name: Tenenbaum, Alexander
name: Iakobishvili, Zaza
name: Peled, Yael
name: Raanani, Ehud
name: Sternik, Leonid
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Science Policy
subject: Hematology
subject: 60506 Virology

description: Additional file 2: Figure S1. Overall 10-year survival curves by revascularization strategy among patients treated by insulin. CABG, Coronary artery bypass graft; PCI, Percutaneous coronary intervention.
An Interdomain Interaction of the Androgen Receptor Is Required for Its Aggregation and Toxicity in Spinal and Bulbar Muscular Atrophy
Creators: name: Liu, Yuhong
name: Orr, Christopher R.
name: Montie, Heather L.
name: Bolzoni, Elena
name: McDonnell, Donald P.
name: Wilson, Elizabeth M.
name: Merry, Diane E.
name: Jenkins, Shannon C.
name: Joseph, James D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Polyglutamine expansion within the androgen receptor (AR) causes spinal and bulbar muscular atrophy (SBMA) and is associated with misfolded and aggregated species of the mutant AR. We showed previously that nuclear localization of the mutant AR was necessary but not sufficient for SBMA. Here we show that an interdomain interaction of the AR that is central to its function within the nucleus is required for AR aggregation and toxicity. Ligands that prevent the interaction between the amino-terminal FXXLF motif and carboxyl-terminal AF-2 domain (N/C interaction) prevented toxicity and AR aggregation in an SBMA cell model and rescued primary SBMA motor neurons from 5α-dihydrotestosterone-induced toxicity. Moreover, genetic mutation of the FXXLF motif prevented AR aggregation and 5α-dihydrotestosterone toxicity. Finally, selective androgen receptor modulators, which prevent the N/C interaction, ameliorated AR aggregation and toxicity while maintaining AR function, highlighting a novel therapeutic strategy to prevent the SBMA phenotype while retaining AR transcriptional function.
title: Not all endovascular clot retrievals are 15 minutes cases. What would you do? An interactive session.
Creators: name: Alsahli, Khalid
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Neuroradiology brain
subject: Interventional vascular
subject: CNS
subject: CT-Angiography
subject: Catheter arteriography
subject: CT
subject: Catheters
subject: Puncture
subject: Thrombolysis
subject: Embolism / Thrombosis
subject: Arteriosclerosis
subject: Ischaemia / Infarction

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: To demonstrate and discuss a challenging endovascular clot retrieval (ECR) case. To illustrate the importance of decision making and efficiency in time-critical ECR cases when faced with...
(4017) Mary Jamieson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Open system quantum annealing in mean field models with exponential degeneracy
Creators: name: Kechedzhi, Kostyantyn
name: Smelyanskiy, Vadim N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Real life quantum computers are inevitably affected by intrinsic noise resulting in dissipative non-unitary dynamics realized by these devices. We consider an open system quantum annealing algorithm optimized for a realistic analog quantum device which takes advantage of noise-induced thermalization and relies on incoherent quantum tunneling at finite temperature. We analyze the performance of this algorithm considering a p-spin model which allows for a mean field quasicalssical solution and at the same time demonstrates the 1st order phase transition and exponential degeneracy of states. We demonstrate that finite temperature effects introduced by the noise are particularly important for the dynamics in presence of the exponential degeneracy of metastable states. We determine the optimal regime of the open system quantum annealing algorithm for this model and find that it can outperform simulated annealing in a range of parameters.
description: 11 pages, 5 figures
Additional file 3 of Revascularization outcomes in diabetic patients presenting with acute coronary syndrome with non-ST elevation
Creators: name: Ram, Eilon
name: Fisman, Enrique Z.
name: Tenenbaum, Alexander
name: Iakobishvili, Zaza
name: Peled, Yael
name: Raanani, Ehud
name: Sternik, Leonid
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Science Policy
subject: Hematology
subject: 60506 Virology

description: Additional file 3: Figure S2. Overall 10-year survival curves by revascularization strategy among oral antiglycemic treated patients. CABG, Coronary artery bypass graft; PCI, Percutaneous coronary intervention.
Mesophyllum expansum (Philippi) comb. nov. (Corallinales, Rhodophytes), et mise au point sur les Mesophyllum des mers d'Europe
Creators: name: CABIOCH, Jacqueline
name: MENDOZA, Maria Laura
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2003

description: Mesophyllum expansum (Philippi) comb. nov (Corallinales, Rhodophyta) and a clarification on the
 Mesophyllum species reported in the European seas. The lectotype of Lithophyllum expansum Philippi, previously
 recognized as a Mesophyllum and considered a heterotypic synonym of Mesophyllum lichenoides, has been reinvestigated
 and compared to recent samples. On the basis of recently introduced new criteria, the taxon is elevated to the rank of species
 and named Mesophyllum expansum (Philippi) comb. nov. Five species of Mesophyllum are thus reported in European
 waters: M. expansum, M. lichenoides, M. alternans, M. macroblastum, M. macedonis. Their main diagnostic features are
 here recalled; this clarification should help to improve in the future the knowledge of bathymetric and geographic
 distribution of these species.
Blocking O -Linked GlcNAc Cycling in Drosophila Insulin-producing Cells Perturbs Glucose-Insulin Homeostasis
Creators: name: Sekine, Osamu
name: Rubenstein, David S.
name: Love, Dona C.
name: Hanover, John A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: A dynamic cycle of O-linked GlcNAc (O-GlcNAc) addition and removal is catalyzed by O-GlcNAc transferase and O-GlcNAcase, respectively, in a process that serves as the final step in a nutrient-driven “hexosamine-signaling pathway.” Evidence points to a role for O-GlcNAc cycling in diabetes and insulin resistance. We have used Drosophila melanogaster to determine whether O-GlcNAc metabolism plays a role in modulating Drosophila insulin-like peptide (dilp) production and insulin signaling. We employed transgenesis to either overexpress or knock down Drosophila Ogt(sxc) and Oga in insulin-producing cells (IPCs) or fat bodies using the GAL4-UAS system. Knockdown of Ogt decreased Dilp2, Dilp3, and Dilp5 production, with reduced body size and decreased phosphorylation of Akt in vivo. In contrast, knockdown of Oga increased Dilp2, Dilp3, and Dilp5 production, increased body size, and enhanced phosphorylation of Akt in vivo. However, knockdown of either Ogt(sxc) or Oga in the IPCs increased the hemolymph carbohydrate concentration. Furthermore, phosphorylation of Akt stimulated by extraneous insulin in an ex vivo cultured fat body of third instar larvae was diminished in strains subjected to IPC knockdown of Ogt or Oga. Knockdown of O-GlcNAc cycling enzymes in the fat body dramatically reduced neutral lipid stores. These results demonstrate that altered O-GlcNAc cycling in Drosophila IPCs modulates insulin production and influences the insulin responsiveness of peripheral tissues. The observed phenotypes in O-GlcNAc cycling mimic pancreatic β-cell dysfunction and glucose toxicity related to sustained hyperglycemia in mammals.
(4012) Jane Samson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Butyrate Promotes Induced Pluripotent Stem Cell Generation
Creators: name: Xia, Kai
name: Zhang, Yi
name: Liang, Gaoyang
name: Taranova, Olena
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Recent studies have demonstrated that embryonic stem cell-like induced pluripotent stem (iPS) cells can be generated by enforced expression of defined transcription factors. The fact that cell fate change is accompanied by changes in epigenetic modifications prompted us to investigate whether chemicals known to modulate epigenetic regulators are capable of enhancing the efficiency of iPS cell generation. Here, we report that butyrate, a natural small fatty acid and histone deacetylase inhibitor, significantly increases the efficiency of mouse iPS cell generation using the transcription factors Oct4, Sox2, Klf4, and c-Myc. We show that butyrate not only changes the reprogramming dynamics, but also increases the ratio of iPS cell colonies to total colonies by reducing the frequency of partially reprogrammed cells and transformed cells. Detailed analysis reveals that the effect of butyrate on reprogramming appears to be mediated by c-Myc and occurs during an early stage of reprogramming. Genome-wide gene expression analysis reveals up-regulation of ES cell-enriched genes when mouse embryonic fibroblasts are treated with butyrate during reprogramming. Thus, our study identifies butyrate as a chemical factor capable of promoting iPS cell generation.
title: Imaging of fatigue stress fractures
Creators: name: Luijkx, Tim
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Musculoskeletal bone
subject: Bones
subject: Extremities
subject: MR
subject: Plain radiographic studies
subject: CT
subject: Diagnostic procedure
subject: Athletic injuries
subject: Occupational / Environmental hazards

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: Providing insight in the etiology and epidemiology of fatigue fractures and learning which imaging modalities are available for diagnosing and monitoring fatigue fractures, their relative performance and pros and cons per...
ACTIVITÉS ENZYMATIQUES DES FRACTIONS SÉRIQUES DE MACROPIPUS PUBER (LINNÉ) MALE SÉPARÉES PAR ÉLECTROPHORÈSE DE ZONE
Creators: name: GHIDALIA, Walter
name: VICOMTE, Marcelle
name: TAN, King Bien
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1971

description: The enzymatic properties of the protein fractions isolated from Macropipus puber (L.) male hemolymph by electrophoresis on filtrating medium have been investigated. Six different activities have been so revealed.
Chemoenzymatic Design of Heparan Sulfate Oligosaccharides
Creators: name: Liu, Jian
name: Linhardt, Robert J.
name: DeAngelis, Paul L.
name: Zhang, Qisheng
name: Bridges, Arlene S.
name: Xu, Yongmei
name: Liu, Renpeng
name: Chen, Miao
name: Zhou, Xianxuan
name: Weïwer, Michel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Heparan sulfate is a sulfated glycan that exhibits essential physiological functions. Interrogation of the specificity of heparan sulfate-mediated activities demands a library of structurally defined oligosaccharides. Chemical synthesis of large heparan sulfate oligosaccharides remains challenging. We report the synthesis of oligosaccharides with different sulfation patterns and sizes from a disaccharide building block using glycosyltransferases, heparan sulfate C5-epimerase, and sulfotransferases. This method offers a generic approach to prepare heparan sulfate oligosaccharides possessing predictable structures.
A new species of Dactylonia Fransen (Crustacea: Decapoda: Pontoniinae) from East Africa
Creators: name: BRUCE, Alexander J.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2003

description: A new species of pontoniine shrimp, Dactylonia franseni sp. nov., (Crustacea: Decapoda: Palaemonidae) from
 Mombasa, Kenya, is described and illustrated on the basis of a single specimen found in association with a tunicate, Ascidia
 sp. The new species is closely related to D. ascidicola but separated by a suite of small characters. Attention is drawn to the
 strong association of Dactylonia species with ascidians of the genus Ascidia.
Cold electron beams from cryo-cooled, alkali antimonide photocathodes
Creators: name: Cultrera, Luca
name: Karkare, Siddharth
name: Lee, Hyeri
name: Liu, Xianghong
name: Bazarov, Ivan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: In this letter we report on the generation of cold electron beams using a Cs3Sb photocathode grown by co-deposition of Sb and Cs. By cooling the photocathode to 90 K we demonstrate a significant reduction in the mean transverse energy validating the long standing speculation that the lattice temperature contribution limits the mean transverse energy or thermal emittance near the photoemission threshold, opening new frontiers in generating ultra-bright beams. At 90 K, we achieve a record low thermal emittance of 0.2 $μ$m (rms) per mm of laser spot diameter from an ultrafast (sub-picosecond) photocathode with quantum efficiency greater than $7\times 10^{-5}$ using a visible laser wavelength of 690 nm.
Two new families, three new genera, and four new species of acoel flatworms (Acoela, Platyhelminthes) from Queensland, Australia
Creators: name: HOOGE, Matthew D.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2003

description: Two new families, three new genera, four new species, and one previously described species of acoel flatworm
 collected from shallow marine sediments in Queensland, Australia are described: Wulguru cuspidata (Convolutidae),
 Stomatricha gen. nov. hochbergi sp. nov. (Otocelididae), and Daku gen. nov. woorimensis sp. nov. (Dakuidae fam. nov.)
 from Bribie Island, Haplogonaria stradbrokensis sp. nov. (Haploposthiidae) from North Stradbroke Island, and Polycanthus
 gen. nov. torosus sp. nov. (Polycanthiidae fam. nov.) from Green Island. The family Dakuidae fam. nov. is characterized by
 having a cone-shaped glandular penis surrounded by a thick seminal vesicle composed of muscles in well-defined
 longitudinal and circular orientations. The family Polycanthiidae fam. nov. is defined by the possession of a cylindrical
 copulatory organ composed of five concentric layers of longitudinal and circular muscles that surround an epithelium-lined
 lumen opening terminally at the posterior end of the animal.
(4013) [J.A.] Macleish
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
CHM-1, a New Vascular Targeting Agent, Induces Apoptosis of Human Umbilical Vein Endothelial Cells via p53-mediated Death Receptor 5 Up-regulation
Creators: name: Wang, Chih Ya
name: Kuo, Sheng Chu
name: Peng, Chieh Yu
name: Sun, Hui Lung
name: Chang, Ya Ling
name: Wang, Shih Wei
name: Teng, Che Ming
name: Tsai, An Chi
name: Pan, Shiow Lin
name: Lee, Kuo Hsiung
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: CHM-1 (2′-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone) has been identified as a potent antitumor agent in human hepatocellular carcinoma; however, its role in tumor angiogenesis is unclear. This study investigated the effects of CHM-1 and the mechanisms by which it exerts its antiangiogenic and vascular disrupting properties. Using a xenograft model antitumor assay, we found that CHM-1 significantly inhibits tumor growth and microvessel formation. Flow cytometry, immunofluorescence microscopy, and cell death enzyme-linked immunosorbent assay kit revealed that CHM-1 inhibits growth of human umbilical vein endothelial cells (HUVEC) by induction of apoptotic cell death in a concentration-dependent manner. CHM-1 also suppresses HUVEC migration and capillary-like tube formation. We were able to correlate CHM-1-induced apoptosis in HUVEC with the cleavage of procaspase-3, -7, and -8, as well as with the cleavage of poly(ADP-ribose) polymerase by Western blotting assay. Such sensitization was achieved through up-regulation of death receptor 5 (DR5) but not DR4 or Fas. CHM-1 was also capable of increasing the expression level of p53, and most importantly, the induction of DR5 by CHM-1 was abolished by p53 small interfering RNA. Taken together, the results of this study indicate that CHM-1 exhibits vascular targeting activity associated with the induction of DR5-mediated endothelial cell apoptosis through p53 up-regulation, which suggests its potential as an antivascular and antitumor therapeutic agent.
title: Audit of contrast-media extravasation in a tertiary hospital
Creators: name: Tang, Victor
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Contrast agents
subject: Professional issues
subject: CT
subject: MR
subject: Safety
subject: Audit and standards
subject: Quality assurance

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The increased accessibility and sophistication of contrast-enhanced imaging has helped improve diagnostic yield. 1 Contrast-media extravasation (CME) is a well-known complication encountered at our tertiary care centre. Extravasation injuries...
Multiple spawning and spawning batch sizein Sepietta oweniana (Cephalopoda: Sepiolidae)
Creators: name: BELLO, Giambattista
name: DEICKERT, Adrianne
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2003

description: In order to gather information on the reproductive strategy of the sepiolid squid Sepietta oweniana, direct
 observations of egg-laying in the aquarium by three wild collected mated females were combined with the examination of
 the ovaries of 59 specimens. The record of multiple spawning events in two aquarium-kept females (two and eight events,
 respectively) and the co-existence in the ovaries of oocytes at various stages of maturation, including mature oocytes,
 showed that S. oweniana is a multiple-spawner. An estimate of the spawning batch size, i.e. the mean number of mature
 oocytes released at each spawning act, was 54.4 eggs; the overall fecundity was estimated to be on the order of 103 eggs.
 The multiple spawning reproductive strategy of this sepiolid squid, which continues to grow during its long reproductive
 phase, was found to differ largely from that of some teuthid squids.
Leptogenesis from left-handed neutrino production during axion inflation
Creators: name: Adshead, Peter
name: Sfakianakis, Evangelos I.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We propose that the observed matter-antimatter asymmetry can be naturally produced as a byproduct of axion-driven slow-roll inflation by coupling the axion to standard-model neutrinos. We assume that GUT scale right-handed neutrinos are responsible for the masses of the standard model neutrinos and that the Higgs field is light during inflation and develops a Hubble scale vacuum expectation value (VEV). In this set up, the rolling axion generates a helicity asymmetry in standard-model neutrinos. Following inflation, this helicity asymmetry becomes equal to a net lepton number as the Higgs VEV decays and is partially re-processed by the $SU(2)_{L}$ sphaleron into a net baryon number.
description: 5 pages, v2: accepted for publication in PRL, manuscript updated to match printed version
title: A rare benign tumour of the breast – fibroadenolipoma, a mimicker of giant phylloides tumour : review of clinical, histopathology and radiological aspects in a young patient.
Creators: name: Kaur, Shaleen
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Breast
subject: Ultrasound
subject: Mammography
subject: MR
subject: Biopsy
subject: Cancer

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: Fibroadenolipoma of the breast is a rare benign solid tumour with the incidence reported in previous literatures is 0.7% of all benign breast tumours in females. 1 This poster will present a case of a breast fibroadenolipoma highlighting its imaging...
Additional file 4 of Revascularization outcomes in diabetic patients presenting with acute coronary syndrome with non-ST elevation
Creators: name: Ram, Eilon
name: Fisman, Enrique Z.
name: Tenenbaum, Alexander
name: Iakobishvili, Zaza
name: Peled, Yael
name: Raanani, Ehud
name: Sternik, Leonid
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Science Policy
subject: Hematology
subject: 60506 Virology

description: Additional file 4: Figure S3. Subgroup analysis: HR with 95% CI for 10 years mortality (PCI vs CABG). CABG, Coronary artery bypass graft; PCI, Percutaneous coronary intervention; HR, Hazard ratio; CI, Confidence interval; MI, Myocardial infarction; CAD, Coronary artery disease.
DIMORFISMO SESSUALE A LIVELLO EMBRIONALE IN PENILIA AVIROSTRIS DANA
Creators: name: GAINO, Elda
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1971

description: Morphological observations on embryos of P. avirostris allow to recognize the males from the females prior their deposition and to describe how such a differentiation takes place. Number and sex of embryos as well as morphometric observations on their development lead to some considerations on the biology of sexual phase of the life cycle of the species.
(4014) John Macleish
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Optimal CMB estimators for bispectra from excited states
Creators: name: Meerburg, P. Daniel
name: Münchmeyer, Moritz
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We propose optimal estimators for bispectra from excited states. Two common properties of such bispectra are the enhancement in the collinear limit, and the prediction of oscillating features. We review the physics behind excited states and some of the choices made in the literature. We show that the enfolded template is a good template in the collinear limit, but does poorly elsewhere, establishing a strong case for an improved estimator. Although the detailed scale dependence of the bispectra differs depending on various assumptions, generally the predicted bispectra are either effectively 1 or 2-dimensional and a simple Fourier basis suffices for accurate reconstruction. For an optimal CMB data analysis, combining all n-point functions, the choice for the excited state needs to be the same when computing power spectrum, bispectrum and higher order correlation functions. This has not always been the case, which could lead to wrong conclusions. We calculate the bispectrum for different choices previously discussed for the power spectrum, setting up a consistent framework to search for evidence of excited states in the CMB data.
description: 19 pages, 9 figures
(4015) Mary M[ichtom]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: AI3SD Interview with Professor Tim Albrecht
Creators: name: Pauli, Michelle
Publisher: name: University of Southampton
Year: 2020
Subjects: subject: AI3SD, Interview, Quantum, Capsule Nets, Deep Learning, Machine Learning, Artificial Intelligence, Chemistry

description: This interview forms part of our AI3SD Interview Series. Professor Tim Albrecht, a Professor of Physical Chemistry at the University of Birmingham was interviewed by Michelle Pauli at our AI3SD Network+ Conference in 2019. Tim is a PI on one of the funding projects from AI3SD-FundingCall1.
Microgeographic genetic variation of populations of Idotea chelipes (Crustacea: Isopoda) in lagoons of the southern English coast
Creators: name: JOLLY1, Marc T.
name: ROGERS, Alex D.
name: SHEADER, Martin
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2003

description: Allozyme variability was examined using starch-gel electrophoresis between sub-populations of Idotea chelipes
 over a small geographic distance (approx. 104 km), in lagoons within the Solent area (Fort Gilkicker Moat; Ashlett Pond)
 and at one site in Dorset (the Fleet Lagoon). Genetic identity values indicate that all three populations are conspecific
(I = 0.967 to 0.995), and mean heterozygosity per locus for all three populations was 8%. Significant levels of genetic
 differentiation (mean FST = 0.119***; p< 0.001) were detected over this small spatial scale, but this mainly resulted from
 the slow esterase locus (mean FST (no esterase) = 0.072***; p< 0.001). Genetic differentiation was moderate given the low
 geographic distances between populations with only one to two migrants per deme per generation (Nem(FST) = 1.85) from
 the Fleet to Gilkicker. There was no significant deviation from the genotypes expected under the Hardy-Weinberg
 equilibrium despite an overall slight excess of heterozygotes (mean FIS = -0.01). Pairwise FST values indicated that there was
 limited genetically effective migration between the sampled lagoons. This genetic differentiation may have been promoted
 by the presence of the Southampton Water and Solent estuarine system that may act as a physical barrier to gene flow for
 this species. The previous use of the esterase (ET2) locus as a sub-specific biochemical marker for Idotea chelipes is placed
 in doubt by this study.
Outer and inner mass distributions of the irregular galaxies UGC 4284 and UGC 11861: Constraining the baryonic content through stellar population synthesis studies
Creators: name: Repetto, P.
name: Martínez-García, Eric E.
name: Rosado, M.
name: Gabbasov, R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: In this article we investigate the outer and inner mass distributions of the irregular galaxies UGC 4284 and UGC 11861, taking advantage of published HI and Hα high resolution rotation curves and constraining the stellar disk of both galaxies throughout stellar population synthesis studies. In addition we take into account the gas content of both galaxies deriving the HI+He rotation curve. The deduced baryonic rotation curves (star+gas) are inadequate to account for the total mass of UGC 4284 and UGC 11861, for that reason we examine the possibility of dark matter to explain the incongruity between the observed HI and Hα rotation curves of UGC 4284 and UGC 11861 and the derived baryonic rotation curves. We consider NFW, Burkert, DiCintio, Einasto, and the Stadel dark matter halos, to analyse the dark matter content of UGC 4284 and UGC 11861. The principal results of this work are that cored dark matter models better reproduce the dark matter Hα and HI rotation curves of UGC 11861 and the dark matter HI rotation curve of UGC 4284, while, the Hα rotation curve of UGC 4284 is better reproduced by a cuspy DiCintio DM model. In general, cored exponential two-parameters models Einasto and Stadel, give better fits than Burkert. This trend, as well as to confirm past results, presents for the first time a comparison between two different exponential dark matter models, Einasto and Stadel, in an attempt to better constrain the range of possible exponential dark matter models applied to real galaxies.
description: Accepted for publication in MNRAS. 19 pages, 15 figures
Distribution, abundance and pollution tolerance of the marine invasive sponge Celtodoryx ciocalyptoides (Burton, 1935) in the Etel River
Creators: name: GENTRIC, Charline
name: SAULEAU, Pierre
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: The distribution and abundance of the marine invasive sponge Celtodoryx ciocalyptoides is described for the first time along the Etel River, a Natura 2000 site of the French Atlantic coast. This invasive species is now well established along both sides of the Etel River and has colonized about 29.3% of the surface of the rocky reef at a depth of 10-18 m. In the Etel marina, C. ciocalyptoides covers all the pilings with a covering rate estimated to 17.4% between 5 and 9 m deep. The bioaccumulation capacities of this species exposed to metallic and organic pollutants (polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and organotin derivatives) was also measured during a three-year study in the Etel marina. Preliminary results suggest this marine invasive species has the capacities to adapt in few months to its changing environment by sequestering and/or metabolizing those pollutants.
An active feedback recovery technique from disruption events induced by m=2 n=1 tearing modes in ohmically heated tokamak plasmas
Creators: name: Zanca, P.
name: Paccagnella, R.
name: Finotti, C.
name: Fassina, A.
name: Manduchi, G.
name: Cavazzana, R.
name: Franz, P.
name: Piron, C.
name: Piron, L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We present experimental results of magnetic feedback control on the m=2, n=1 tearing mode in RFX-mod operated as a circular ohmically heated tokamak. The feedback suppression of the non-resonant m=2, n=1 Resistive Wall Mode (RWM) in q(a)<2 plasmas is a well-established result of RFX-mod. The control of the tearing counterpart, which develops in q(a)>2 equilibrium, is instead a more difficult issue. In fact, the disruption induced by a growing amplitude m=2, n=1 tearing mode can be prevented by feedback only when the resonant surface q=2 is close to the plasma edge, namely 2