cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Motivically functorial coniveau spectral sequences; direct summands of cohomology of function fields
Creators: name: Bondarko, M. V.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Algebraic Geometry (math.AG)
subject: K-Theory and Homology (math.KT)
subject: FOS: Mathematics
subject: 14F42, 14C35, 18G40, 19E15, 14F20, 14C25, 14C35

description: We construct a 'triangulated analogue' of coniveau spectral sequences: the motif of a variety over a countable field is 'decomposed' (in the sense of Postnikov towers) into the twisted (co)motives of its points; this is generalized to arbitrary Voevodsky's motives. To this end we construct a 'Gersten' weight structure for a certain triangulated category of 'comotives': the latter is defined to contain comotives for all projective limits of smooth varieties; the definition of a weight structure was introduced in a preceding paper. The corresponding weight spectral sequences are essentially coniveau one; they are $DM^{eff}_{gm}$-functorial (starting from $E_2$) and can be computed in terms of the homotopy $t$-structure for the category $DM^-_{eff}$ (similarly to the case of smooth varieties). This extends to motives the seminal coniveau spectral sequence computations of Bloch and Ogus. We also obtain that the cohomology of a smooth semi-local scheme is a direct summand of the cohomology of its generic fibre; cohomology of function fields contain twisted cohomology of their residue fields (for all geometric valuations). We also develop further the general theory of weight structures for triangulated categories (independently from the 'motivic' part of the paper). Besides, we develop a certain theory of 'nice' pairings of triangulated categories; this subject seems to be new.
description: A few minor corrections made
title: ÐÐ½Ð¶ÐµÐ½ÐµÑÐ½Ð¾Ðµ Ð±Ð»Ð°Ð³Ð¾ÑÑÑÑÐ¾Ð¹ÑÑÐ²Ð¾ ÐºÐ¾ÑÑÐµÐ´Ð¶Ð½Ð¾Ð³Ð¾ Ð¿Ð¾ÑÐµÐ»ÐºÐ° Ð Ð¾ÑÑÐ¾Ð²ÑÐºÐ¾Ð¹ Ð¾Ð±Ð»Ð°ÑÑÐ¸
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÑÐºÐ¾Ð²Ð°, ÐÐµÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: Ð²ÐµÑÑÐ¸ÐºÐ°Ð»ÑÐ½Ð°Ñ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²ÐºÐ° ÑÐµÑÑÐ¸ÑÐ¾ÑÐ¸Ð¹
Ð²Ð¾Ð´Ð¾Ð¾ÑÐ²ÐµÐ´ÐµÐ½Ð¸Ðµ
Ð»Ð¾ÐºÐ°Ð»ÑÐ½ÑÐµ Ð¾ÑÐ¸ÑÑÐ½ÑÐµ ÑÐ¾Ð¾ÑÑÐ¶ÐµÐ½Ð¸Ñ

description: ÐÐ°ÑÑÐ¾ÑÑÐ°Ñ Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ° ÑÐ¾Ð´ÐµÑÐ¶Ð¸Ñ Ð¾Ð¿Ð¸ÑÐ°Ð½Ð¸Ðµ Ð¸ ÑÐ°ÑÑÐµÑ Ð¸Ð½Ð¶ÐµÐ½ÐµÑÐ½ÑÑ ÑÐµÑÐµÐ½Ð¸Ð¹ Ð¿Ð¾ Ð±Ð»Ð°Ð³Ð¾ÑÑÑÑÐ¾Ð¹ÑÑÐ²Ñ ÐºÐ¾ÑÑÐµÐ´Ð¶Ð½Ð¾Ð³Ð¾ Ð¿Ð¾ÑÐµÐ»ÐºÐ° Ð Ð¾ÑÑÐ¾Ð²ÑÐºÐ¾Ð¹ Ð¾Ð±Ð»Ð°ÑÑÐ¸. ÐÐ¾Ð¼Ð¸Ð¼Ð¾ Ð´ÐµÑÐ°Ð»ÑÐ½Ð¾Ð¹ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð²ÐµÑÑÐ¸ÐºÐ°Ð»ÑÐ½Ð¾Ð¹ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²ÐºÐ¸, ÑÐ°Ð±Ð¾ÑÐ° ÑÐ¾Ð´ÐµÑÐ¶Ð¸Ñ ÑÐ°Ð·Ð´ÐµÐ»Ñ, Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð½ÑÐµ Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð²Ð¾Ð´Ð¾Ð¾ÑÐ²Ð¾Ð´ÑÑÐ¸Ñ Ð¸ Ð²Ð¾Ð´Ð¾Ð¿Ð¾Ð½Ð¸Ð¶Ð°ÑÑÐ¸Ñ ÑÐ¸ÑÑÐµÐ¼. ÐÑÐ¾ÐµÐºÑÐ¸ÑÑÐµÐ¼Ð°Ñ ÑÐ¸ÑÑÐµÐ¼Ð° Ð²Ð¾Ð´Ð¾Ð¾ÑÐ²ÐµÐ´ÐµÐ½Ð¸Ñ Ð¿ÑÐµÐ´Ð¿Ð¾Ð»Ð°Ð³Ð°ÐµÑ ÑÑÑÑÐ¾Ð¹ÑÑÐ²Ð¾ Ð² Ð¿ÑÐµÐ´ÐµÐ»Ð°Ñ ÑÐ»Ð¸ÑÐ½Ð¾Ð¹ Ð·Ð°ÑÑÑÐ¾Ð¹ÐºÐ¸ Ð´Ð²ÑÑ ÑÐ°Ð¼Ð¾ÑÑÐ¾ÑÑÐµÐ»ÑÐ½ÑÑ Ð·Ð°ÐºÑÑÑÑÑ ÑÐµÑÐµÐ¹: Ð±ÑÑÐ¾Ð²Ð¾Ð¹ Ð¸ Ð´Ð¾Ð¶Ð´ÐµÐ²Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼ ÐºÐ°Ð½Ð°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸. ÐÐ¾Ð¿Ð¾Ð»Ð½Ð¸ÑÐµÐ»ÑÐ½Ð¾ Ð±ÑÐ»Ð¸ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ñ ÑÐµÑÐµÐ½Ð¸Ñ Ð´Ð»Ñ Ð²Ð¾Ð´Ð¾Ð¾ÑÐ²ÐµÐ´ÐµÐ½Ð¸Ñ Ñ Ð¸Ð½Ð´Ð¸Ð²Ð¸Ð´ÑÐ°Ð»ÑÐ½ÑÑ Ð¶Ð¸Ð»ÑÑ ÑÑÐ°ÑÑÐºÐ¾Ð² Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð»Ð¾ÐºÐ°Ð»ÑÐ½ÑÑ Ð¾ÑÐ¸ÑÑÐ½ÑÑ ÑÐ¾Ð¾ÑÑÐ¶ÐµÐ½Ð¸Ð¹.
Additional file 3 of Insights from Leishmania (Viannia) guyanensis in vitro behavior and intercellular communication
Creators: name: Pereira, Luiza O. R.
name: Sousa, Cíntia S.
name: Ramos, Hellen C. P.
name: Torres-Santos, Eduardo C.
name: Pinheiro, Liliane S.
name: Alves, Marcelo R.
name: Cuervo, Patricia
name: Romero, Gustavo A. Sierra
name: Boité, Mariana C.
name: Porrozzi, Renato
name: Cupolillo, Elisa
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 3: Table S2. Area under curve (AUC) values for Fig. 2 curves.
Simple Universal Bounds for Chebyshev-Type Quadratures
Creators: name: Peled, Ron
Publisher: name: arXiv
Year: 2009
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Numerical Analysis (math.NA)
subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 41A55, 60D05

description: A Chebyshev-type quadrature for a probability measure sigma is a distribution which is uniform on n points and has the same first k moments as sigma. We give an upper bound for the minimal n required to achieve a given degree k, for sigma supported on an interval. In contrast to previous results of this type, our bound uses only simple properties of sigma and is applicable in wide generality. We also obtain a lower bound for the required number of nodes which only uses estimates on the moments of sigma. Examples illustrating the sharpness of our bounds are given. As a corollary of our results, we obtain an apparently new result on the Gaussian quadrature. In addition, we suggest another approach to bounding the minimal number of nodes required in a Chebyshev-type quadrature, utilizing a random choice of the nodes, and propose the challenge of analyzing its performance. A preliminary result in this direction is proved for the uniform measure on the cube. Finally, we apply our bounds to the construction of point sets on the sphere and cylinder which form local approximate Chebyshev-type quadratures. These results were needed recently in the context of understanding how well can a Poisson process approximate certain continuous distributions. The paper concludes with a list of open questions.
description: 33 pages. Revised version with improved exposition and text. A new example shows the upper bound on the minimal number of nodes can be attained up to constants.
The Observed Growth of Massive Galaxy Clusters II: X-ray Scaling Relations
Creators: name: Mantz, Adam
name: Allen, Steven W.
name: Ebeling, Harald
name: Rapetti, David
name: Drlica-Wagner, Alex
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: (Abridged) This is the second in a series of papers in which we derive simultaneous constraints on cosmology and X-ray scaling relations using observations of massive, X-ray flux-selected galaxy clusters. The data set consists of 238 clusters drawn from the ROSAT All-Sky Survey with 0.1-2.4 keV luminosities >2.5e44 erg/second, and incorporates extensive follow-up observations using the Chandra X-ray Observatory. Our analysis accounts self-consistently for all selection effects, covariances and systematic uncertainties. Here we describe the reduction of the follow-up X-ray observations, present results on the cluster scaling relations, and discuss their implications. Our constraints on the luminosity-mass and temperature-mass relations, measured within r_500, lead to three important results. First, the data support the conclusion that excess heating of the intracluster medium has altered its thermodynamic state from that expected in a simple, gravitationally dominated system; however, this excess heating is primarily limited to the central regions of clusters (r<0.15r_500). Second, the intrinsic scatter in the center-excised luminosity-mass relation is remarkably small, being undetected at the <10% level in current data; for the hot, massive clusters under investigation, this scatter is smaller than in either the temperature-mass or Y_X-mass relations (10-15%). Third, the evolution with redshift of the scaling relations is consistent with the predictions of simple, self-similar models of gravitational collapse, indicating that the mechanism responsible for heating the central regions of clusters was in operation before redshift 0.5 (the limit of our data) and that its effects on global cluster properties have not evolved strongly since then.
description: 25 pages, 7 figures, 14 tables. v3: final version (typographic corrections). Results can be downloaded at https://www.stanford.edu/group/xoc/papers/xlf2009.html
title: ÐÐ±ÑÐµÐ¼Ð½Ð°Ñ ÑÐµÐ»Ð°ÐºÑÐ°ÑÐ¸Ñ Ð¿Ð¾Ð»ÑÑÐ¸Ð·Ð¾Ð²Ð°Ð½Ð½ÑÑ ÑÑÐµÐºÐ¾Ð»
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
Creators: name: ÐÐ°Ð±Ð´ÑÐ°ÑÐ¼Ð°Ð½Ð¾Ð²Ð°, ÐÐ»Ð¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: Ð¡ÑÐµÐºÐ»Ð¾ Ð½Ð°ÑÑÐ¸ÐµÐ²Ð¾ÑÐ¸Ð»Ð¸ÐºÐ°ÑÐ½Ð¾Ðµ
ÐÐ½Ð¾Ð´Ð½Ð°Ñ Ð¿Ð¾Ð»ÑÑÐ¸Ð·Ð°ÑÐ¸Ñ
ÐÑÐ¶Ð¸Ð³

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¸Ð·Ð»Ð¾Ð¶ÐµÐ½Ñ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ ÑÐµÐ»Ð°ÐºÑÐ°ÑÐ¸Ð¸ Ð¾Ð±ÑÐµÐ¼Ð° Ð¿Ð¾Ð»ÑÑÐ¸Ð·Ð¾Ð²Ð°Ð½Ð½ÑÑ ÑÑÐµÐºÐ¾Ð» Ð¿ÑÐ¸ ÑÐµÐ¼Ð¿ÐµÑÐ°ÑÑÑÐ°Ñ Ð²ÑÑÐµ ÑÐµÐ¼Ð¿ÐµÑÐ°ÑÑÑÑ Ð¿Ð¾Ð»ÑÑÐ¸Ð·Ð°ÑÐ¸Ð¸ (Ð¿Ð»Ð¾ÑÑ Ð´Ð¾ ÑÐµÐ¼Ð¿ÐµÑÐ°ÑÑÑ ÑÑÐµÐºÐ»Ð¾Ð²Ð°Ð½Ð¸Ñ). ÐÐ¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ Ð¿ÑÐ¸ Ð²ÑÑÐ¾ÐºÐ¾ÑÐµÐ¼Ð¿ÐµÑÐ°ÑÑÑÐ½Ð¾Ð¼ Ð¾ÑÐ¶Ð¸Ð³Ðµ Ð¿Ð¾Ð»ÑÑÐ¸Ð·Ð¾Ð²Ð°Ð½Ð½ÑÑ Ð¾Ð±Ð»Ð°ÑÑÐµÐ¹ ÑÑÐµÐºÐ¾Ð» Ð¸Ñ Ð¾Ð±ÑÐµÐ¼ Ð¼Ð¾Ð¶ÐµÑ ÑÐ¼ÐµÐ½ÑÑÐ¸ÑÑÑÑ Ð´Ð¾ ÑÑÐµÑ ÑÐ°Ð·. ÐÐ°Ð½Ñ ÑÐµÑÐ¼Ð¾Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¾Ðµ Ð¸ ÑÐµÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ðµ Ð¾Ð±ÑÑÑÐ½ÐµÐ½Ð¸Ðµ Ð½Ð°Ð±Ð»ÑÐ´Ð°ÐµÐ¼Ð¾Ð³Ð¾ ÑÑÑÐµÐºÑÐ°. ÐÐ·ÑÑÐµÐ½Ð½ÑÐ¹ ÑÑÑÐµÐºÑ ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÐµÑÑÑ Ð² ÐºÐ¾Ð½ÑÐµÐºÑÑÐµ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð½Ð¾Ð²Ð¾Ð¹ ÑÑÑÐ¾Ð¹ Ð»Ð¸ÑÐ¾Ð³ÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐ½ÑÑ ÑÐµÐ»ÑÐµÑÐ½ÑÑ ÑÑÑÑÐºÑÑÑ, Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð½Ð¾Ð¹ Ð½Ð° Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ð¿Ð¾Ð»ÑÑÐ¸Ð·Ð°ÑÐ¸Ð¸ Ð¼Ð½Ð¾Ð³Ð¾ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÐ½ÑÑ ÑÑÐµÐºÐ¾Ð» Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ ÑÑÑÑÐºÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÑ (ÑÐµÐ»ÑÐµÑÐ½ÑÑ) ÑÐ»ÐµÐºÑÑÐ¾Ð´Ð¾Ð², Ð´Ð»Ñ Ð·Ð°Ð´Ð°Ñ Ð¼Ð¸ÐºÑÐ¾ÑÐ»ÑÐ¸Ð´Ð¸ÐºÐ¸, Ð´Ð¸ÑÑÐ°ÐºÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ Ð¾Ð¿ÑÐ¸ÐºÐ¸, Ð¸Ð½ÑÐµÐ³ÑÐ°Ð»ÑÐ½Ð¾Ð¹ Ð¾Ð¿ÑÐ¸ÐºÐ¸ Ð¸ Ð´ÑÑÐ³Ð¸Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ð¹.
On the Relationship Between Molecular Hydrogen and Carbon Monoxide Abundances in Molecular Clouds
Creators: name: Glover, S. C. O.
name: Mac Low, M. -M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The most usual tracer of molecular gas is line emission from CO. However, the reliability of that tracer has long been questioned in environments different from the Milky Way. We study the relationship between H2 and CO abundances using a fully dynamical model of magnetized turbulence coupled to a chemical network simplified to follow only the dominant pathways for H2 and CO formation and destruction, and including photodissociation using a six-ray approximation. We find that the abundance of H2 is primarily determined by the amount of time available for its formation, which is proportional to the product of the density and the metallicity, but insensitive to photodissociation. Photodissociation only becomes important at extinctions under a few tenths of a visual magnitude, in agreement with both observational and prior theoretical work. On the other hand, CO forms quickly, within a dynamical time, but its abundance depends primarily on photodissociation, with only a weak secondary dependence on H2 abundance. As a result, there is a sharp cutoff in CO abundance at mean visual extinctions A_V < 3. At lower values of A_V we find that the ratio of H2 column density to CO emissivity X_CO is proportional to A_V^(-3.5). This explains the discrepancy observed in low metallicity systems between cloud masses derived from CO observations and other techniques such as infrared emission. Our work predicts that CO-bright clouds in low metallicity systems should be systematically larger or denser than Milky Way clouds, or both. Our results further explain the narrow range of observed molecular cloud column densities as a threshold effect, without requiring the assumption of virial equilibrium.
description: 16 pages, 11 figures. Updated to match version accepted by MNRAS
Additional file 6 of Insights from Leishmania (Viannia) guyanensis in vitro behavior and intercellular communication
Creators: name: Pereira, Luiza O. R.
name: Sousa, Cíntia S.
name: Ramos, Hellen C. P.
name: Torres-Santos, Eduardo C.
name: Pinheiro, Liliane S.
name: Alves, Marcelo R.
name: Cuervo, Patricia
name: Romero, Gustavo A. Sierra
name: Boité, Mariana C.
name: Porrozzi, Renato
name: Cupolillo, Elisa
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 6: Table S5. P-values for pairwise comparisons among co-culture assays (failure strain).
Neuro-protective potential of a vesicular system of a standardized extract of a new chemotype of Withania somnifera Dunal (NMITLI118RT+) against cerebral stroke in rats*
Creators: name: Ahmad, Hafsa
name: Khandelwal, Kiran
name: Sheeba Saji Samuel
name: Shivangi Tripathi
name: Mitra, Kalyan
name: Sangwan, Rajender Singh
name: Shukla, Rakesh
name: Dwivedi, Anil Kumar
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Withania somnifera Dunal is an Indian medicinal plant with significant pharmacological properties, such as adaptogenic, anti-inflammatory, anti-oxidant, anti-platelet, anti-hypertensive, hypoglycemic and hypolipidemic effects. Several chemotypes of W. somnifera include NMITLI-101, NMITLI-118 and NMITLI-128. The present work elaborates the optimization and development of a liposomal delivery system for efficient delivery of NMITLI118RT+ [a standardized ethanolic extract of a new chemotype of W. somnifera Dunal (NMITLI-118) roots] against cerebral stroke in rats. Liposomal systems were prepared using thin-film hydration method and characterized on the basis of size, zeta potential, physical stability, FT-IR, DSC-TGA analysis and surface morphological studies by TEM. NMITLI118RT+ and its formulations (NMITLI118RT+LF) were evaluated for biological activity utilizing middle cerebral artery occlusion model in rats. The Z average of the developed liposomal formulation was about 142.6 ± 0.09 nm with a zeta potential of −31.20 ± 1.0 mV. Results of TEM revealed spherical particles in the range of 200 nm. The entrapment efficiency was found to be 94.603 ± 2%. The formulation was found to be physically stable over a 3-week period. Results were suggestive of the fact that both NMITLI118RT+ and its delivery system possess significant neuroprotective activity in cerebral ischemia. The liposomal system largely exhibits better performance over NMITLI118RT+ precisely in the post-treatment group. The present studies could elucidate the successful development of a delivery system for NMITLI118RT+ and demonstrate their beneficial neuro-protective potential in overcoming and reversing the consequences of I/R injury following stroke.
title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ Ð³ÐµÐ¾Ð¼ÐµÑÑÐ¸Ð¸ ÑÑÐ°Ð½Ð¸Ð½Ñ Ð½Ð° ÑÐµÑ Ð½Ð¸ÐºÐ¾-ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»Ð¸ Ð´Ð²Ð¸Ð³Ð°ÑÐµÐ»Ñ Ð¿Ð¾ÑÑÐ¾ÑÐ½Ð½Ð¾Ð³Ð¾ ÑÐ¾ÐºÐ° Ð¼Ð¾ÑÐ½Ð¾ÑÑÑÑ 26.5 ÐºÐÑ
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: Ð¤Ð¾Ð¼Ð¸Ð½, ÐÐ»Ð°Ð´Ð¸ÑÐ»Ð°Ð²
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: Ð³Ð°Ð±Ð°ÑÐ¸ÑÐ½Ð¾-ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»Ð¸ Ð´Ð²Ð¸Ð³Ð°ÑÐµÐ»Ñ
ÑÐ»ÐµÐºÑÑÐ¾Ð¼Ð°Ð³Ð½Ð¸ÑÐ½ÑÐ¹ ÑÐ°ÑÑÐµÑ
ÑÐµÐ¿Ð»Ð¾Ð²Ð¾Ð¹ ÑÐ°ÑÑÐµÑ

description: Ð¦ÐµÐ»ÑÑ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐ²Ð»ÑÐµÑÑÑ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ Ð³Ð°Ð±Ð°ÑÐ¸ÑÐ½Ð¾-ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»ÐµÐ¹ Ð´Ð²Ð¸Ð³Ð°ÑÐµÐ»Ñ Ð¿Ð¾ÑÑÐ¾ÑÐ½Ð½Ð¾Ð³Ð¾ ÑÐ¾ÐºÐ° Ð¼Ð¾ÑÐ½Ð¾ÑÑÑÑ 26,5ÐºÐÑ Ñ Ð¿ÑÑÐ¼Ð¾ÑÐ³Ð¾Ð»ÑÐ½Ð¾Ð¹ ÑÑÐ°Ð½Ð¸Ð½Ð¾Ð¹ Ð¸ ÐµÐ³Ð¾ Ð°Ð½Ð°Ð»Ð¾Ð³Ð° Ð¼Ð¾ÑÐ½Ð¾ÑÑÑÑ 26,5ÐºÐÑ Ñ ÐºÑÑÐ³Ð»Ð¾Ð¹ ÑÑÐ°Ð½Ð¸Ð½Ð¾Ð¹. Ð­Ð»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð´Ð²Ð¸Ð³Ð°ÑÐµÐ»Ð¸ ÑÐ²Ð»ÑÑÑÑÑ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÐ¼Ð¸ Ð¿ÑÐµÐ¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°ÑÐµÐ»ÑÐ¼Ð¸ ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ½ÐµÑÐ³Ð¸Ð¸ Ð² Ð¼ÐµÑÐ°Ð½Ð¸ÑÐµÑÐºÑÑ Ð¸ ÑÐ¾ÑÑÐ°Ð²Ð»ÑÑÑ Ð¾ÑÐ½Ð¾Ð²Ñ ÑÐ»ÐµÐºÑÑÐ¾Ð¿ÑÐ¸Ð²Ð¾Ð´Ð° Ð±Ð¾Ð»ÑÑÐ¸Ð½ÑÑÐ²Ð° Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð¾Ð², Ð¸ÑÐ¿Ð¾Ð»ÑÐ·ÑÐµÐ¼ÑÑ Ð²Ð¾ Ð²ÑÐµÑ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð°Ñ. ÐÐ»Ñ Ð´Ð¾ÑÑÐ¸Ð¶ÐµÐ½Ð¸Ñ Ð¿Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾Ð¹ ÑÐµÐ»Ð¸ Ð² ÑÐ°Ð±Ð¾ÑÐµ ÑÐµÑÐ°Ð»Ð¸ÑÑ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÐµ Ð·Ð°Ð´Ð°ÑÐ¸: Ð²ÑÐ¿Ð¾Ð»Ð½Ð¸ÑÑ ÑÐ»ÐµÐºÑÑÐ¾Ð¼Ð°Ð³Ð½Ð¸ÑÐ½ÑÐ¹ Ð¸ ÑÐµÐ¿Ð»Ð¾Ð²Ð¾Ð¹ ÑÐ°ÑÑÐµÑÑ Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÑÐµÐ¼Ð¾Ð³Ð¾ Ð´Ð²Ð¸Ð³Ð°ÑÐµÐ»Ñ; Ð¸Ð·ÑÑÐ¸ÑÑ ÑÑÑÐµÑÑÐ²ÑÑÑÐ¸Ðµ Ð¼ÐµÑÐ¾Ð´Ñ ÑÐ°ÑÑÐµÑÐ° Ð¼Ð°ÑÐ¸Ð½ Ð¿Ð¾ÑÑÐ¾ÑÐ½Ð½Ð¾Ð³Ð¾ ÑÐ¾ÐºÐ° Ð¸ Ð½Ð°Ð¼ÐµÑÐ¸ÑÑ Ð¿ÑÑÐ¸ Ð¸Ñ ÑÑÐ¾ÑÐ½ÐµÐ½Ð¸Ñ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ ÑÐ¸ÑÐ»ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¼Ð°Ð³Ð½Ð¸ÑÐ½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ñ Ð² Ð²Ð¾Ð·Ð´ÑÑÐ½Ð¾Ð¼ Ð·Ð°Ð·Ð¾ÑÐµ Ð¼Ð°ÑÐ¸Ð½Ñ; ÑÐ¾Ð¿Ð¾ÑÑÐ°Ð²Ð¸ÑÑ ÑÐµÑÐ½Ð¸ÐºÐ¾-ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»Ð¸ ÑÐ¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð´Ð²Ð¸Ð³Ð°ÑÐµÐ»Ñ Ð¸ ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÑÑÐµÐ³Ð¾ Ð°Ð½Ð°Ð»Ð¾Ð³Ð°; ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÑÑ Ð¿ÑÐµÐ¸Ð¼ÑÑÐµÑÑÐ²Ð° Ð¸ Ð½ÐµÐ´Ð¾ÑÑÐ°ÑÐºÐ¸ Ð·Ð°Ð¼ÐµÐ½Ñ Ð³ÐµÐ¾Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¾ÑÐ¼Ñ ÑÑÐ°Ð½Ð¸Ð½Ñ Ñ ÑÐ¸Ð»Ð¸Ð½Ð´ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð½Ð° Ð¿ÑÑÐ¼Ð¾ÑÐ³Ð¾Ð»ÑÐ½ÑÑ.
Computational analysis of drug transport in tumor microenvironment as a critical compartment for nanotherapeutic pharmacokinetics
Creators: name: Ziemys, Arturas
name: Klemm, Steve
name: Milosevic, Miljan
name: Yokoi, Kenji
name: Ferrari, Mauro
name: Milos Kojic
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Over the last decade, nanotherapeutics gained increasingly important role in drug delivery because of their frequently beneficial pharmacokinetics (PK) and lower toxicity when compared to classical systemic drug delivery. In view of therapeutic payload delivery, convective transport is crucial for systemic distribution via circulatory system, but the target domain is tissue outside vessels where transport is governed by diffusion. Here, we have computationally investigated the understudied interplay of physical transports to characterize PK of payload of nanotherapeutics. The analysis of human vasculature tree showed that convective transport is still 5 times more efficient than diffusion suggesting that circulating and payload releasing drug vectors can contribute mostly to systemic delivery. By comparing payload delivery using systemic circulation and drug vectors to microenvironment, internalized vectors were the most efficient and showed Area under the Curve almost 100 higher than in systemic delivery. The newly introduced zone of influence parameter indicated that vectors, especially internalized, lead to the largest tissue fraction covered with therapeutically significant payload concentration. The internalization to microenvironment minimizes effects of plasma domain on payload extravasation from nanotherapeutics. The computed results showed that classical PK, which mostly relies on concentration profiles in plasma, sometimes might be inadequate or not sufficient in explaining therapeutic efficacy of nanotherapeutics. These results provide a deeper look into PK of drug vectors and can help in the design of better drug delivery strategies.
Stable limits for sums of dependent infinite variance random variables
Creators: name: Bartkiewicz, Katarzyna
name: Jakubowski, Adam
name: Mikosch, Thomas
name: Wintenberger, Olivier
Publisher: name: arXiv
Year: 2009
Subjects: subject: Probability (math.PR)
subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: The aim of this paper is to provide conditions which ensure that the affinely transformed partial sums of a strictly stationary process converge in distribution to an infinite variance stable distribution. Conditions for this convergence to hold are known in the literature. However, most of these results are qualitative in the sense that the parameters of the limit distribution are expressed in terms of some limiting point process. In this paper we will be able to determine the parameters of the limiting stable distribution in terms of some tail characteristics of the underlying stationary sequence. We will apply our results to some standard time series models, including the GARCH(1, 1) process and its squares, the stochastic volatility models and solutions to stochastic recurrence equations.
description: 35 pages
Change in Jewish religious life
Creators: name: Kogen, David Chaim
Publisher: name: University of British Columbia
Year: 2012

description: The aim of this thesis is to study the problem of change in Jewish religious life. At the outset, a brief historical review of the development of Jewish religious law is sketched In order to introduce the reader to some of the religious problems which have faced the Jews during the past two centuries. The second chapter outlines the four most important modern approaches to the problem of change: Reform, Neo-Orthodox, Conservative, and Reconstructionist. In connection with each of these movements, the reader will find a brief history, explanation of principles, and evaluation. A study of Jewish religious life in Vancouver is presented in the third chapter to show the extent of social change away from the norm of Orthodoxy that has taken place in the Jewish religious life of this community. Wherever possible, comparisons are made with the Jewish community of Minneapolis, one of the few that have been studied, in order to ascertain if Vancouver is typical. In the last chapter certain conclusions are reached about the need for change in Jewish religious life. Conclusions are reached after considering the history of Jewish religious law, the modern attempts to change this law, and the extent to which contemporary Jews observe Jewish religious law.
Quantum Field Theories on Algebraic Curves. I. Additive bosons
Creators: name: Takhtajan, Leon A.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Algebraic Geometry (math.AG)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Algebra (math.QA)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 81R10, 14H81

description: Using Serre's adelic interpretation of cohomology, we develop a `differential and integral calculus' on an algebraic curve X over an algebraically closed filed k of constants of characteristic zero, define algebraic analogs of additive multi-valued functions on X and prove corresponding generalized residue theorem. Using the representation theory of the global Heisenberg and lattice Lie algebras, we formulate quantum field theories of additive and charged bosons on an algebraic curve X. These theories are naturally connected with the algebraic de Rham theorem. We prove that an extension of global symmetries (Witten's additive Ward identities) from the k-vector space of rational functions on X to the vector space of additive multi-valued functions uniquely determines these quantum theories of additive and charged bosons.
description: 31 pages, published version. Invariant formulation added, multiplicative section removed
Development and characterization of lysine-methotrexate conjugate for enhanced brain delivery
Creators: name: Singh, Vijay Kumar
name: Subudhi, Bharat Bhusan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Background information: Methotrexate (MTX), an anticancer drug of choice, has poor permeability across blood-brain barrier (BBB) making it unsuitable for brain tumor application. Its brain availability and scope of application was improved by preparation of reversible conjugate with lysine by capitalizing the endogenous transport system of lysine at BBB. Methods: To enhance its delivery to brain, MTX was reversibly conjugated with l-Lysine by an amide linkage. It was characterized by advanced spectroscopy techniques including IR, NMR and MS. Furthermore, conjugate was assessed for stability, toxicity and drug release ability. In vivo distribution studies were done by radioscintigraphy study using 99mTc radioisotope. Results: The structure of prodrug was confirmed by 1H-NMR, 13C-NMR and Mass. The m/e (mass to charge ratio) fragment was found at [M + H] 711.32 in Mass spectra. Stability and metabolic studies suggested that conjugate was stable at physiological pH (in Phosphate buffer pH 7.4 t1/2 is 70.25 ± 2.17 h and in plasma t1/2 is 193.57 ± 2.03 min) and circulated adequately to release MTX slowly in brain. In vivo biodistribution study showed that prodrug significantly increased the level of MTX in brain when compared with pharmacokinetic parameter of parent drug. Conclusion: The brain permeability of MTX was enhanced significantly by this conjugate.
MPEC 2023-K66 : COMET P/2014 OL465 (PANSTARRS)
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: COMET P/2014 OL465 (PANSTARRS)

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Additional file 1 of Susceptible trichostrongyloid species mask presence of benzimidazole-resistant Haemonchus contortus in cattle
Creators: name: Mohammedsalih, Khalid M.
name: Krücken, Jürgen
name: Bashar, Ahmed
name: Juma, Fathel-Rahman
name: Abdalmalaik, Abdalhakaim A. H.
name: Khalafalla, Amna
name: Abakar, Adam
name: Coles, Gerald
name: von Samson-Himmelstjerna, Georg
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Arithmetic means of egg counts (and 95% confidence interval) with cattle naturally infected with strongyle nematodes before and after oral administration of albendazole at dose of 7.5 mg/kg body weight to the treated groups at five different study areas in South Darfur State, Sudan
title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÑÐ¸ÑÐ¼ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÑÐ¸Ð»Ñ Ð´Ð»Ñ Ð¼Ð°Ð³Ð°Ð·Ð¸Ð½Ð° ÑÑÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ½Ð°ÑÑÐ¶ÐµÐ½Ð¸Ñ.
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ¸ÑÐ¸Ð³Ð¸Ð½, ÐÐ»Ð°Ð´Ð¸Ð¼Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: ÑÐ¸ÑÐ¼ÐµÐ½Ð½ÑÐ¹ ÑÑÐ¸Ð»Ñ
ÑÑÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¾Ðµ ÑÐ½Ð°ÑÑÐ¶ÐµÐ½Ð¸Ðµ
ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÑÑÐ¸Ð»Ñ

description: ÐÑÐ¿ÑÑÐºÐ½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° ÑÐ¾Ð´ÐµÑÐ¶Ð¸Ñ 49 ÑÑÑÐ°Ð½Ð¸Ñ, 57 Ð¸Ð»Ð»ÑÑÑÑÐ°ÑÐ¸Ð¹, 25 Ð¸ÑÑÐ¾ÑÐ½Ð¸ÐºÐ¾Ð², 1 Ð¿ÑÐ¸Ð»Ð¾Ð¶ÐµÐ½Ð¸Ðµ. ÐÐ¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð½ÑÐµ Ð·Ð°Ð´Ð°ÑÐ¸: Ð¿ÑÐ¾Ð¸Ð·Ð²ÐµÑÑÐ¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¾Ð± Ð¸ÑÑÐ¾ÑÐ¸Ð¸ Ð¸ Ð·Ð½Ð°ÑÐµÐ½Ð¸Ð¸ ÑÐ¸ÑÐ¼ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÑÐ¸Ð»Ñ ÐºÐ°Ðº ÑÐ°ÐºÐ¾Ð²Ð¾Ð³Ð¾; Ð¿ÑÐ¾Ð¸Ð·Ð²ÐµÑÑÐ¸ Ð¾Ð±Ð·Ð¾Ñ Ð°Ð½Ð°Ð»Ð¾Ð³Ð¾Ð², Ñ.Ðµ. Ñ ÑÐµÐ»ÑÑ ÑÑÐµÑÐ° Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÐµÐ»ÑÐ½ÑÑ ÑÐµÐ½Ð´ÐµÐ½ÑÐ¸Ð¹ Ð¸ Ð¾ÑÐµÐ²Ð¸Ð´Ð½ÑÑ Ð¾ÑÐ¸Ð±Ð¾Ðº ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÑÑ Ð¸ Ð¿ÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°ÑÑ Ð»Ð¾Ð³Ð¾ÑÐ¸Ð¿Ñ ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ð¹, Ð·Ð°Ð½Ð¸Ð¼Ð°ÑÑÐ¸ÑÑÑ Ð°Ð½Ð°Ð»Ð¾Ð³Ð¸ÑÐ½Ð¾Ð¹ Ð¿Ð¾ ÑÐ¿ÐµÑÐ¸ÑÐ¸ÐºÐµ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÑÑ; Ð¾Ð¿ÑÐµÐ´ÐµÐ»Ð¸ÑÑ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ Ð¿ÑÐ¸Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ ÑÑÐ¸Ð»Ð¸Ð¹ Ð² Ð°ÑÐ¿ÐµÐºÑÐµ ÑÑÐ¸Ð»Ð¸ÑÑÐ¸ÐºÐ¸ Ð¾Ð±ÑÐ°Ð·Ð°, Ñ.Ðµ. ÑÑÐ¾ÑÐ¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°ÑÑ ÐºÐ¾Ð½ÑÐµÐ¿ÑÐ¸Ñ Ð¸Ð¼Ð¸Ð´Ð¶Ð° ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ð¸; Ð¸ÑÑÐ¾Ð´Ñ Ð¸Ð· Ð²ÑÐ±ÑÐ°Ð½Ð½Ð¾Ð³Ð¾ Ð¸Ð¼Ð¸Ð´Ð¶Ð° (ÑÑÑÐ¾Ð³Ð¸Ð¹, ÑÐ¿Ð¾ÐºÐ¾Ð¹Ð½ÑÐ¹, Ð²ÐµÑÐµÐ»ÑÐ¹ Ð¸ Ñ.Ð¿.) ÑÐ¾Ð·Ð´Ð°ÑÑ ÑÐ²ÐµÑÐ¾Ð²ÑÑ Ð³Ð°Ð¼Ð¼Ñ, Ð¿Ð¾Ð´Ð¾Ð±ÑÐ°ÑÑ ÑÐ¼ÐµÑÑÐ½ÑÐ¹ Ð¸ Ð³Ð°ÑÐ¼Ð¾Ð½Ð¸ÑÐ½ÑÐ¹ ÑÑÐ¸ÑÑ; ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°ÑÑ Ð¿ÑÐ°Ð²Ð¸Ð»Ð° Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¾Ð·Ð´Ð°Ð²Ð°ÐµÐ¼Ð¾Ð³Ð¾ ÑÐ¸ÑÐ¼ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÑÐ¸Ð»Ñ; ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°ÑÑ ÑÑÐ¸Ð»Ð¸ÑÑÐ¸ÐºÑ Ð½Ð°Ð½ÐµÑÐµÐ½Ð¸Ñ ÑÐ¸ÑÐ¼ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð±Ð»Ð¾ÐºÐ° Ð½Ð° Ð½Ð¾ÑÐ¸ÑÐµÐ»Ð¸. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ ÑÐ¾Ð·Ð´Ð°Ð½ ÑÐ½Ð¸ÐºÐ°Ð»ÑÐ½ÑÐ¹ ÑÐ¸ÑÐ¼ÐµÐ½Ð½ÑÐ¹ ÑÑÐ¸Ð»Ñ Ð² ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²Ð¸Ð¸ Ñ Ð¿Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð½ÑÐ¼Ð¸ Ð·Ð°Ð´Ð°ÑÐ°Ð¼Ð¸, Ð²Ð½ÑÑÑÐµÐ½Ð½Ð¸Ð¼ ÑÐ±ÐµÐ¶Ð´ÐµÐ½Ð¸ÐµÐ¼, Ð»Ð¸ÑÐ½ÑÐ¼ Ð¿Ð¾Ð½ÑÑÐ¸ÐµÐ¼ ÑÑÐ¸Ð»Ñ Ð¸ Ð²ÐºÑÑÐ°. Ð ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÑÐºÐ¾Ð¹ Ð¸ ÑÐ²Ð¾ÑÑÐµÑÐºÐ¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ, Ð¸Ð·Ð½Ð°ÑÐ°Ð»ÑÐ½Ð¾ Ð¿Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð½ÑÐµ Ð·Ð°Ð´Ð°ÑÐ¸ Ð±ÑÐ»Ð¸ ÑÐµÑÐµÐ½Ñ Ð² Ð¿Ð¾Ð»Ð½Ð¾Ð¼ Ð¾Ð±ÑÐµÐ¼Ðµ: Ð¸Ð·ÑÑÐµÐ½Ñ Ð¸ÑÑÐ¾ÐºÐ¸ Ð¿ÑÐ¾Ð¸ÑÑÐ¾Ð¶Ð´ÐµÐ½Ð¸Ñ ÑÐ¸ÑÐ¼ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÑÐ¸Ð»Ñ, Ð¾Ð¿Ð¸ÑÐ°Ð½Ñ ÐµÐ³Ð¾ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÐ¸ Ð¸ Ð·Ð½Ð°ÑÐµÐ½Ð¸Ðµ Ð² ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð¹ ÑÐµÐºÐ»Ð°Ð¼Ðµ; ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½ ÑÐ¸ÑÐ¼ÐµÐ½Ð½ÑÐ¹ ÑÑÐ¸Ð»Ñ ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ð¹, ÑÐ¿ÐµÑÐ¸Ð°Ð»Ð¸Ð·Ð¸ÑÑÑÑÐ¸ÑÑÑ Ð½Ð° Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ðµ Ð¸ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ ÑÑÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐ¾Ð²Ð°ÑÐ¾Ð²; Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÐ¹ ÑÐ¸ÑÐ¼ÐµÐ½Ð½ÑÐ¹ Ð±Ð»Ð¾Ðº ÐºÐ¾Ð½ÑÑÐ°ÑÑÐµÐ½, ÐºÐ¾Ð¼Ð¿Ð°ÐºÑÐµÐ½, Ð²Ð¿Ð¾Ð»Ð½Ðµ Ð³Ð°ÑÐ¼Ð¾Ð½Ð¸ÑÐµÐ½ Ð¿Ð¾ ÑÐ¾ÑÐ¼Ðµ Ð¸ ÑÐ¾Ð¿Ð¾Ð´ÑÐ¸Ð½ÐµÐ½Ð¸Ñ ÑÐ»ÐµÐ¼ÐµÐ½ÑÐ¾Ð², Ð² ÑÐ¸Ð»Ñ Ð¼Ð¾Ð½Ð¾ÑÑÐ¾Ð¼Ð½Ð¾Ð¹ ÑÐ²ÐµÑÐ¾Ð²Ð¾Ð¹ Ð³Ð°Ð¼Ð¼Ñ Ð¸Ð¼ÐµÐµÑ ÑÐµÑÐºÐ¸Ðµ Ð»Ð¸Ð½Ð¸Ð¸ Ð¸ Ð¾ÑÐµÑÑÐ°Ð½Ð¸Ñ.
A dynamical classification of the range of pair interactions
Creators: name: Gabrielli, Andrea
name: Joyce, Michael
name: Marcos, Bruno
name: Sicard, Francois
Publisher: name: arXiv
Year: 2010
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We formalize a classification of pair interactions based on the convergence properties of the {\it forces} acting on particles as a function of system size. We do so by considering the behavior of the probability distribution function (PDF) P(F) of the force field F in a particle distribution in the limit that the size of the system is taken to infinity at constant particle density, i.e., in the "usual" thermodynamic limit. For a pair interaction potential V(r) with V(r) \rightarrow \infty) \sim 1/r^a defining a {\it bounded} pair force, we show that P(F) converges continuously to a well-defined and rapidly decreasing PDF if and only if the {\it pair force} is absolutely integrable, i.e., for a > d-1, where d is the spatial dimension. We refer to this case as {\it dynamically short-range}, because the dominant contribution to the force on a typical particle in this limit arises from particles in a finite neighborhood around it. For the {\it dynamically long-range} case, i.e., a \leq d-1, on the other hand, the dominant contribution to the force comes from the mean field due to the bulk, which becomes undefined in this limit. We discuss also how, for a \leq d-1 (and notably, for the case of gravity, a=d-2) P(F) may, in some cases, be defined in a weaker sense. This involves a regularization of the force summation which is generalization of the procedure employed to define gravitational forces in an infinite static homogeneous universe. We explain that the relevant classification in this context is, however, that which divides pair forces with a > d-2 (or a < d-2), for which the PDF of the {\it difference in forces} is defined (or not defined) in the infinite system limit, without any regularization. In the former case dynamics can, as for the (marginal) case of gravity, be defined consistently in an infinite uniform system.
description: 12 pages, 1 figure; significantly shortened and focussed, additional references, version to appear in J. Stat. Phys
Additional file 7 of Insights from Leishmania (Viannia) guyanensis in vitro behavior and intercellular communication
Creators: name: Pereira, Luiza O. R.
name: Sousa, Cíntia S.
name: Ramos, Hellen C. P.
name: Torres-Santos, Eduardo C.
name: Pinheiro, Liliane S.
name: Alves, Marcelo R.
name: Cuervo, Patricia
name: Romero, Gustavo A. Sierra
name: Boité, Mariana C.
name: Porrozzi, Renato
name: Cupolillo, Elisa
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 7: Table S6. Co-culture strategies and density variations under media sharing.
Effort, Obstacles, and MCII - Virtual Bike Racing Study
Creators: name: Riddell, Hugh
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: goal striving
subject: MCII
subject: motivation

description: This project investigates how motives and Mental Contrasting with Implementation Intentions contribute to effort and ease of goal striving.
title: Ð­ÐºÐ¾Ð½Ð¾Ð¼Ð¸ÐºÐ¾-Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¾Ð½Ð½ÑÐµ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ñ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð¼Ð°Ð»ÑÑ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ð¹ Ð² ÑÐ¾ÑÐ³Ð¾Ð²Ð»Ðµ
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: Ð©ÐµÑÐ±Ð°ÐºÐ¾Ð²Ð°, ÐÐºÐ°ÑÐµÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: Ð¼Ð°Ð»ÑÐ¹ Ð±Ð¸Ð·Ð½ÐµÑ
ÑÑÐ±ÑÐµÐºÑÑ Ð¼Ð°Ð»Ð¾Ð³Ð¾ Ð¿ÑÐµÐ´Ð¿ÑÐ¸Ð½Ð¸Ð¼Ð°ÑÐµÐ»ÑÑÑÐ²Ð°
Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½Ð°Ñ Ð¿Ð¾Ð´Ð´ÐµÑÐ¶ÐºÐ°
swot-Ð°Ð½Ð°Ð»Ð¸Ð·
pest-Ð°Ð½Ð°Ð»Ð¸Ð·
ÑÐ¸Ð½Ð°Ð½ÑÐ¾Ð²Ð°Ñ ÑÑÑÐ¾Ð¹ÑÐ¸Ð²Ð¾ÑÑÑ
ÑÐµÐ½ÑÐ°Ð±ÐµÐ»ÑÐ½Ð¾ÑÑÑ
Ð±Ð¸Ð·Ð½ÐµÑ-Ð¿ÑÐ¾ÑÐµÑÑ

description: ÐÑÐ¿Ð¾Ð»Ð½ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÐµÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð°ÑÐ¿ÐµÐºÑÐ¾Ð² ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ ÑÑÐ±ÑÐµÐºÑÐ¾Ð² Ð¼Ð°Ð»Ð¾Ð³Ð¾ Ð¿ÑÐµÐ´Ð¿ÑÐ¸Ð½Ð¸Ð¼Ð°ÑÐµÐ»ÑÑÑÐ²Ð°. ÐÑÐ°ÑÐ°ÐºÑÐµÑÐ¸Ð·Ð¾Ð²Ð°Ð½Ð¾ Ð¿Ð¾Ð½ÑÑÐ¸Ðµ Ð¸ ÑÑÑÐ½Ð¾ÑÑÑ Ð¼Ð°Ð»Ð¾Ð³Ð¾ Ð±Ð¸Ð·Ð½ÐµÑÐ°, Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð¾Ð² Ð¿Ð¾Ð´Ð´ÐµÑÐ¶ÐºÐ¸ Ð¼Ð°Ð»ÑÑ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ð¹. ÐÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ñ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»Ð¸ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ ÐÐÐ Â«ÐÐÐ ÐÐÐ­ÐÐ¡Â». ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· Ð²Ð½ÑÑÑÐµÐ½Ð½ÐµÐ¹ Ð¸ Ð²Ð½ÐµÑÐ½ÐµÐ¹ ÑÑÐµÐ´Ñ, Ð²ÑÑÐ²Ð»ÐµÐ½Ñ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ ÑÐ»ÑÑÑÐµÐ½Ð¸Ñ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¸ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ñ Ð¿ÑÑÐ¸ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÐµÐµ ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ.
title: ÐÐ¸Ð·Ð½ÐµÑ-ÑÐµÐ½ÑÑ Ñ ÐºÐ¾Ð¼Ð±Ð¸Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¼ ÑÐ½ÐµÑÐ³Ð¾ÑÑÑÐµÐºÑÐ¸Ð²Ð½ÑÐ¼ Ð¾ÑÑÐµÐºÐ»ÐµÐ½Ð¸ÐµÐ¼
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: Ð¡ÐµÐ¼ÐµÐ½Ð¾Ð², ÐÐ¸ÐºÐ¸ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: Ð°ÑÑ Ð¸ÑÐµÐºÑÑÑÐ½ÑÐµ ÑÐµÑÐµÐ½Ð¸Ñ
ÑÐ½ÐµÑÐ³Ð¾ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾Ðµ Ð¾ÑÑÐµÐºÐ»ÐµÐ½Ð¸Ðµ
Ð¸Ð½Ð¶ÐµÐ½ÐµÑÐ½Ð¾Ðµ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ
ÑÐ¼ÐµÑÐ½ÑÐ¹ ÑÐ°ÑÑÐµÑ

description: Ð Ð½Ð°ÑÑÐ¾ÑÑÐµÐµ Ð²ÑÐµÐ¼Ñ Ð² ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð¼ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÑÑÐ²Ðµ Ð°ÐºÑÑÐ°Ð»ÑÐ½Ð° Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ð° ÑÐ½ÐµÑÐ³Ð¾ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð·Ð´Ð°Ð½Ð¸Ð¹. ÐÐ¾Ð¼Ð±Ð¸Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ðµ ÑÐ½ÐµÑÐ³Ð¾ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾Ðµ Ð¾ÑÑÐµÐºÐ»ÐµÐ½Ð¸Ðµ Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÐµÑ ÑÐ°ÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°ÑÑ ÑÐ½ÐµÑÐ³Ð¸Ñ Ð¸ Ð·Ð½Ð°ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾ ÑÐ½Ð¸Ð·Ð¸ÑÑ Ð·Ð°ÑÑÐ°ÑÑ Ð¸ ÑÐ°ÑÑÐ¾Ð´Ñ Ð½Ð° ÑÐºÑÐ¿Ð»ÑÐ°ÑÐ°ÑÐ¸Ñ Ð·Ð´Ð°Ð½Ð¸Ñ. Ð¡ ÑÑÐµÑÐ¾Ð¼ Ð´Ð°Ð½Ð½Ð¾Ð¹ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ñ Ð² Ð´Ð°Ð½Ð½Ð¾Ð¹ Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ¾Ð¹ Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð±ÑÐ» ÑÐ¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½ Ð±Ð¸Ð·Ð½ÐµÑ-ÑÐµÐ½ÑÑ Ñ ÐºÐ¾Ð¼Ð±Ð¸Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¼ ÑÐ½ÐµÑÐ³Ð¾ÑÑÑÐµÐºÑÐ¸Ð²Ð½ÑÐ¼ Ð¾ÑÑÐµÐºÐ»ÐµÐ½Ð¸ÐµÐ¼.
Emergent universe from the Hořava-Lifshitz gravity
Creators: name: Wu, Puxun
name: Yu, Hongwei
Publisher: name: arXiv
Year: 2009
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the stability of the Einstein static universe in the Hořava-Lifshitz (HL) gravity and a generalized version of it formulated by Sotiriou, Visser and Weifurtner. We find that, for the HL cosmology, there exists a stable Einstein static state if the cosmological constant $Λ$ is negative. The universe can stay at this stable state eternally and thus the big bang singularity can be avoided. However, in this case, the Universe can not exit to an inflationary era. For the Sotiriou, Visser and Weifurtner HL cosmology, if the cosmic scale factor satisfies certain conditions initially, the Universe can stay at the stable state past eternally and may undergo a series of infinite, nonsingular oscillations. Once the parameter of the equation of state $w$ approaches a critical value, the stable critical point coincides with the unstable one, and the Universe enters an inflationary era. Therefore, the big bang singularity can be avoided and a subsequent inflation can occur naturally.
description: 23 pages, 11 figures and 3 tables; title changed,comprehensive analysis added, published version
Neuro-protective potential of a vesicular system of a standardized extract of a new chemotype of Withania somnifera Dunal (NMITLI118RT+) against cerebral stroke in rats*
Creators: name: Ahmad, Hafsa
name: Khandelwal, Kiran
name: Sheeba Saji Samuel
name: Shivangi Tripathi
name: Mitra, Kalyan
name: Sangwan, Rajender Singh
name: Shukla, Rakesh
name: Dwivedi, Anil Kumar
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Withania somnifera Dunal is an Indian medicinal plant with significant pharmacological properties, such as adaptogenic, anti-inflammatory, anti-oxidant, anti-platelet, anti-hypertensive, hypoglycemic and hypolipidemic effects. Several chemotypes of W. somnifera include NMITLI-101, NMITLI-118 and NMITLI-128. The present work elaborates the optimization and development of a liposomal delivery system for efficient delivery of NMITLI118RT+ [a standardized ethanolic extract of a new chemotype of W. somnifera Dunal (NMITLI-118) roots] against cerebral stroke in rats. Liposomal systems were prepared using thin-film hydration method and characterized on the basis of size, zeta potential, physical stability, FT-IR, DSC-TGA analysis and surface morphological studies by TEM. NMITLI118RT+ and its formulations (NMITLI118RT+LF) were evaluated for biological activity utilizing middle cerebral artery occlusion model in rats. The Z average of the developed liposomal formulation was about 142.6 ± 0.09 nm with a zeta potential of −31.20 ± 1.0 mV. Results of TEM revealed spherical particles in the range of 200 nm. The entrapment efficiency was found to be 94.603 ± 2%. The formulation was found to be physically stable over a 3-week period. Results were suggestive of the fact that both NMITLI118RT+ and its delivery system possess significant neuroprotective activity in cerebral ischemia. The liposomal system largely exhibits better performance over NMITLI118RT+ precisely in the post-treatment group. The present studies could elucidate the successful development of a delivery system for NMITLI118RT+ and demonstrate their beneficial neuro-protective potential in overcoming and reversing the consequences of I/R injury following stroke.
title: ÐÐ´Ð´Ð¸ÑÐ¸Ð²Ð½ÑÐµ ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ð¸
title: ÑÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ
titleType: Subtitle
Creators: name: Ð ÑÐ´ÑÐºÐ¾Ð¹, ÐÐ½Ð´ÑÐµÐ¹
name: ÐÐ¾Ð¿Ð¾Ð²Ð¸Ñ, ÐÐ½Ð°ÑÐ¾Ð»Ð¸Ð¹
name: ÐÑÐ¸Ð³Ð¾ÑÑÐµÐ², ÐÐ»ÐµÐºÑÐµÐ¹
name: ÐÐ°Ð»ÐµÐ´Ð¸Ð½Ð°, ÐÐ¸Ð°Ð½Ð°
Publisher: name: ÐÐ·Ð´-Ð²Ð¾ ÐÐ¾Ð»Ð¸ÑÐµÑÐ½. ÑÐ½-ÑÐ°
Year: 2017
Subjects: ÐÐ°ÑÐ¸Ð½Ð¾ÑÑÑÐ¾ÐµÐ½Ð¸Ðµ
ÐÐ°ÑÐ¸Ð½Ð½Ð°Ñ Ð³ÑÐ°ÑÐ¸ÐºÐ°
Ð°Ð´Ð´Ð¸ÑÐ¸Ð²Ð½ÑÐµ ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ð¸

description: ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ñ Ð²Ð¾Ð¿ÑÐ¾ÑÐ° Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð², ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¹ Ð¸ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð´Ð»Ñ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð¸Ñ Ð¸Ð·Ð´ÐµÐ»Ð¸Ð¹ Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸ÐµÐ¼ Ð°Ð´Ð´Ð¸ÑÐ¸Ð²Ð½ÑÑ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¹. ÐÐ¿Ð¸ÑÐ°Ð½Ñ ÑÑÑÐµÑÑÐ²ÑÑÑÐ¸Ðµ ÑÐ¿Ð¾ÑÐ¾Ð±Ñ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð¸Ñ Ð¸Ð·Ð´ÐµÐ»Ð¸Ð¹ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð°Ð´Ð´Ð¸ÑÐ¸Ð²Ð½ÑÑ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¹, Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ð½ÑÐµ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ñ, ÐºÐ¾ÑÐ¾ÑÑÐµ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·ÑÑÑÑÑ Ð² ÑÑÐ¸Ñ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸ÑÑ, Ð° ÑÐ°ÐºÐ¶Ðµ ÑÑÑÐµÑÑÐ²ÑÑÑÐµÐµ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð² ÑÑÐ¾Ð¹ Ð¾Ð±Ð»Ð°ÑÑÐ¸. Ð ÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð¾Ð²Ð°Ð½Ð¾ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ ÑÑÐµÐ±Ð½Ð¾Ð³Ð¾ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ñ Ð´Ð»Ñ ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð² Ð¸ Ð°ÑÐ¿Ð¸ÑÐ°Ð½ÑÐ¾Ð² Ð²ÑÑÑÐ¸Ñ ÑÑÐµÐ±Ð½ÑÑ Ð·Ð°Ð²ÐµÐ´ÐµÐ½Ð¸Ð¹, Ð´Ð»Ñ Ð°ÑÐ¿Ð¸ÑÐ°Ð½ÑÐ¾Ð² Ð½Ð°ÑÑÐ½Ð¾-Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÑÐºÐ¸Ñ Ð¸Ð½ÑÑÐ¸ÑÑÑÐ¾Ð², Ð¾Ð±ÑÑÐ°ÑÑÐ¸ÑÑÑ Ð¿Ð¾ ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¼ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸ÑÐ¼. Ð¢Ð°ÐºÐ¶Ðµ Ð¼Ð¾Ð¶ÐµÑ Ð±ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¾ Ð´Ð»Ñ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ Ð¸Ð½Ð¶ÐµÐ½ÐµÑÐ½ÑÑ ÐºÐ°Ð´ÑÐ¾Ð² Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð°Ð´Ð´Ð¸ÑÐ¸Ð²Ð½ÑÑ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¹.
description: ÐÐµÑÐ°ÑÐ°ÐµÑÑÑ Ð¿Ð¾ ÑÐµÑÐµÐ½Ð¸Ñ Ð¡Ð¾Ð²ÐµÑÐ° Ð¿Ð¾ Ð¸Ð·Ð´Ð°ÑÐµÐ»ÑÑÐºÐ¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð£ÑÐµÐ½Ð¾Ð³Ð¾ ÑÐ¾Ð²ÐµÑÐ°
Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑÐ° ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾.
Generation of Bianchi Type V String Cosmological Models with Bulk Viscosity
Creators: name: Yadav, Anil Kumar
Publisher: name: arXiv
Year: 2009
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Bianchi type V string cosmological models with bulk viscosity for massive string are investigated. The bulk viscosity is assumed to vary with time in such a manner that it is related to simple power function of the energy density. Using generation technique (Camci~et~al., 2001), it is shown that Einstein's field equations are solvable for any arbitrary cosmic scale function. Solution for particular form of cosmic scale functions are also obtained. It is found that solutions based on generation technique are relevant to the observational results. Some physical and geometrical aspect of the models are also discussed.
description: 12 pages, 3 figures, Typose removed, To appear in Rom. Rep. Physics
Development and characterization of lysine-methotrexate conjugate for enhanced brain delivery
Creators: name: Singh, Vijay Kumar
name: Subudhi, Bharat Bhusan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Background information: Methotrexate (MTX), an anticancer drug of choice, has poor permeability across blood-brain barrier (BBB) making it unsuitable for brain tumor application. Its brain availability and scope of application was improved by preparation of reversible conjugate with lysine by capitalizing the endogenous transport system of lysine at BBB. Methods: To enhance its delivery to brain, MTX was reversibly conjugated with l-Lysine by an amide linkage. It was characterized by advanced spectroscopy techniques including IR, NMR and MS. Furthermore, conjugate was assessed for stability, toxicity and drug release ability. In vivo distribution studies were done by radioscintigraphy study using 99mTc radioisotope. Results: The structure of prodrug was confirmed by 1H-NMR, 13C-NMR and Mass. The m/e (mass to charge ratio) fragment was found at [M + H] 711.32 in Mass spectra. Stability and metabolic studies suggested that conjugate was stable at physiological pH (in Phosphate buffer pH 7.4 t1/2 is 70.25 ± 2.17 h and in plasma t1/2 is 193.57 ± 2.03 min) and circulated adequately to release MTX slowly in brain. In vivo biodistribution study showed that prodrug significantly increased the level of MTX in brain when compared with pharmacokinetic parameter of parent drug. Conclusion: The brain permeability of MTX was enhanced significantly by this conjugate.
PAPEL DO PROFISSIONAL DE ENFERMAGEM EM PROCEDIMENTOS CIRÚRGICOS ROBÓTICOS: UMA REVISÃO DE ESCOPO
Creators: name: Costa, Andreia Cristina Barbosa
name: Roseira, Luis Guilherme Fernandes
name: Robazzi, Maria Lucia Do Carmo Cruz
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Medicine and Health Sciences
subject: Life Sciences
subject: Nursing
subject: FOS: Health sciences

description: This is a scoping review that aims to map the scientific evidence about the role of nursing professionals in robotic surgical procedures, the main trends, gaps and contributions to current scientific knowledge.
The seasonal variation of the temperature and salinity of the surface waters of the British Columbia coast
Creators: name: McLeod, Donald Cameron
Publisher: name: University of British Columbia
Year: 2012

description: For a number of years daily observations of surface temperature and salinity have been taken at ooeanographic stations (mostly lighthouses) on the B. C. coast. The present thesis is the first attempt that has been made to systematically analyse this data. The annual variation in temperature was seen to follow the general climatological trend of the B. C. coast at each of the stations, although a wide range in the amplitudes of these periodic variations was noted. The factors influencing the amplitude of the annual temperature curves were considered and such effects as incoming radiation, the extent of turbulence, the degree of shelter and the phenomena of upwelling due to horizontal wind stress (West Coast of Vancouver Island) have been discussed for each of the stations. Correlations were made between available meteorological information and the sea temperature observations and an attempt has been made to determine temperature contours of the B. C. coastal waters during the summer when the surface temperature is least uniform. The salinity observations were treated in an analogous manner to temperature and found to exhibit characteristic periodic annual variations. The stations were classified by means of these variations and the influences of precipitation and fresh water runoff, evaporation and mixing were discussed and correlations with meteorological observations were again made.