cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
STRUCTURAL HEALTH MONITORING OF FILAMENT WOUND GLASS FIBER/EPOXY COMPOSITES WITH CARBON BLACK FILLER VIA ELECTRICAL IMPEDANCE TOMOGRAPHY
Creators: name: Jacob Thomas, Akshay
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Aerospace materials
Aerospace structures
Composite and hybrid materials
Functional materials

description: Fiber reinforced polymer composites are widely used in manufacturing advanced light weight structures for the aerospace, automotive, and energy sectors owing to their superior stiffness and strength. With the increasing use of composites, there is an increasing need to monitor the health of these structures during their lifetime. Currently, health monitoring in filament wound composites is facilitated by embedding piezoelectrics and optical fibers in the composite during the manufacturing process. However, the incorporation of these sensing elements introduces sites of stress concentration which could lead to progressive damage accumulation. In addition to introducing weak spots in the structure, they also make the manufacturing procedure difficult. Alternatively, nanofiller modification of the matrix imparts conductivity which can be leveraged for real time health monitoring with fewer changes to the manufacturing method. Well dispersed nanofillers act as an integrated sensing network. Damage or strain severs the well-connected nanofiller network thereby causing a local change in conductivity. The self-sensing capabilities of these modified composites can be combined with low cost, minimally invasive imaging modalities such as electrical impedance tomography (EIT) for damage detection. To date, however, EIT has exclusively been used for damage detection in planar coupons. These simple plate-like structures are not representative of real-world complex geometries. This thesis advances the state of the art in conductivity-based structural health monitoring (SHM) and nondestructive evaluation (NDE) by addressing this limitation of EIT. The current study will look into damage detection of a non-planar multiply connected domain – a filament-wound glass fiber/epoxy tube modified by carbon black (CB) filler. The results show that EIT is able to detect through holes as small as 7.94 mm in a tube with length-to-diameter ratio of 132.4 mm-to-66.2 mm (aspect ratio of 2:1). Further, the sensitivity of EIT to damage improved with decreasing tube aspect ratio. EIT was also successful in detecting sub-surface damage induced by low velocity impacts. These results indicate that EIT has much greater potential for composite SHM and NDE than prevailing work limited to planar geometries suggest.
sj-docx-3-hol-10.1177_09596836211033202 – Supplemental material for Potential of Arabic documentary sources for reconstructing past climate in the western Mediterranean region from AD 680 to 1815
Creators: name: Meklach, Yassin
name: Camenisch, Chantal
name: Merzouki, Abderrahmane
name: Garcia Herrera, Ricardo
Publisher: name: SAGE Journals
Year: 2021
Subjects: Geography
History

description: Supplemental material, sj-docx-3-hol-10.1177_09596836211033202 for Potential of Arabic documentary sources for reconstructing past climate in the western Mediterranean region from AD 680 to 1815 by Yassin Meklach, Chantal Camenisch, Abderrahmane Merzouki and Ricardo Garcia Herrera in The Holocene
Additional file 1 of Nanoparticles systemically biodistribute to regenerating skeletal muscle in DMD
Creators: name: Hicks, Michael R.
name: Liu, Xiangsheng
name: Young, Courtney S.
name: Saleh, Kholoud
name: Ji, Ying
name: Jiang, Jinhong
name: Emami, Michael R.
name: Mokhonova, Ekaterina
name: Spencer, Melissa J.
name: Meng, Huan
name: Pyle, April D.
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 1: Figure S1. IV injection of MSNPs biodistribute to severely dystrophic mdx-DBA/2 and immunocompromised mdx-NSG mice. A. Ex vivo NIR fluorescence imaging of muscles at 24 h after animals received IV injection of NIR-labeled lipids coated 70 nm MSNPs (50 mg/kg). B. Immunofluorescent staining of gastrocnemius in mdx-NSG and mdx-DBA/2 mice demonstrate abundant MSNP aggregation in skeletal muscle tissue. Secondary antibody (2y) shows background autofluorescence in skeletal muscle does not co-localize with MSNPs. Scale bars represent 100 μm.
Additional file 1 of Usefulness of lactate to albumin ratio for predicting in-hospital mortality in atrial fibrillation patients admitted to the intensive care unit: a retrospective analysis from MIMIC-IV database
Creators: name: Huang, Ting
name: Lin, Sen
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified

description: Supplementary Material 1
Strut-and-Tie Evaluation Program (STEP) for the Design of Bridge Components
Creators: name: Vicksman, Andi S
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Structural engineering

description: The strut-and-tie method (STM) is a powerful tool used for the design of D-regions (disturbed regions) of reinforced concrete structures. Many typical bridge substructure components consist of D-regions and require the use of the STM for design. Implementation of the STM is more complex than typical design methods, and engineers are often unfamiliar with the design process. As a result, designing using the STM is more time consuming than traditional design methods. The Indiana Department of Transportation (INDOT) identified a need for a tool that assists with the design of typical bridge substructure components using the STM. STEP (Strut-and-Tie Evaluation Program) is a computer program created to fulfill this role. To use the computer program, engineers input geometric conditions, material properties, and reinforcement information for a structural component. STEP uses this information to develop a strut-and-tie model and perform STM design procedures. A graphical representation of the model and a summary of the design results are provided as program outputs for the user. STEP, created using Excel VBA, is intended to aid in the design of multi-column bent caps and integral and semi-integral end bent caps. Within this thesis, an overview of the STM is provided, including the basic procedures for designing using the STM. An introduction to Excel VBA is also presented. The document describes the layout and formatting of the computer program, required user inputs, and program outputs. Furthermore, limitations and assumptions within the computer program for the substructure components are also included. Finally, design examples focused on the use of STEP for the design of a five-column bent cap and an integral end bent cap are presented. This document can be used as a resource for engineers when designing bridge substructure components using STEP.
MyHealthMyData (MHMD): Deliverable 3.3 - Onboarding User Interface for Web and App Design
Creators: name: Essafi, Daniel
name: Williams, Yoseph
Publisher: name: Zenodo
Year: 2018

description: The MHMD user interfaces will allow users to share data efficiently and safely using the MHMD blockchain. There are several different users and user stories. This document follows on from project deliverable D1.1 Gnubila‘s UI Eye-catching Analytics Module’ presentation delivered in Rome Dec ‘17, and face to face discussions with consortium members. The primary aim is to present designs suitable for implementation in a short three-month time frame for a proof of concept demonstration in project month 18.

HWC prepared early smartphone app designs for feedback in Q4 2017 and early web designs for feedback in Q1 2018. This document covers the amendments to the designs that were presented and reviewed by the consortium in Feb & early March 2018

In the following pages, we have included key marketing messages that are suggestions or decent placeholders in advance of detailed feedback from the consortium.

Note. There will be UI design that reflects and implements the business model the consortium decides upon. Finalising the business model will happen in the second half of the project. As such, only placeholders relevant to the business/monetisation model have been included.
Understanding the Role of Ligand Oxidation State: Design. Synthesis, and Reactivity of Electronically Asymmetric Molybdenum Dithiolene Complexes
Creators: name: Dille, Sara Ashley
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Inorganic chemistry not elsewhere classified

description: Mononuclear molybdopterin enzymes are a large class of enzymes that are present in all phyla of life. All pterin containing enzymes posses a molybdopterin cofactor made up of a molybdenum metal center coordinated directly by a dithiolene ligand, which is appended to a pyranopterin cofactor. The majority of these enzymes catalyze oxygen atom transfer reactions that are concomitant with a transfer of two-electrons. We are hypothesizing that by altering the oxidation states of the dithiolene, the reactivity of the cofactor can be tuned for different substrates. This investigation focuses on the synthesis and characterization of oxo-MoIV(dithiolene) complexes that possess a fully reduced dithiolene ligand (dithiolene) and a fully oxidized dithiolene ligand (dithione). These complexes are designed to represent the asymmetry of the dithiolene ligand that is observed in the crystal structures of the DMSO reductase family. Asymmetric oxo-MoIV(dithiolene) complexes exhibit a unique structural property, a large fold angle along the S···S vector of the dithione ligand. These complexes also show a positive solvatochromic effect in a range of polar to nonpolar solvents. The rich electrochemical properties of these redox active complexes and other characterization details such as IR, and NMR studies will be presented. Effects on the reactivity of these complexes using biologically relevant substrates will be discussed. The oxygen atom transfer reactivity has been probed by mass spectrometry and NMR spectroscopy. The presented complexes aide in highlighting the effect redox state of the dithiolene ligand has in modulating reactivity.
Additional file 1 of Harm reduction behaviours and harm experiences of people who use 3,4-methylenedioxymethamphetamine (MDMA) in Aotearoa New Zealand
Creators: name: Whelan, Jai
name: Noller, Geoff
name: Ward, Ryan D.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Supplementary Material 1
sj-docx-1-psp-10.1177_01461672211025945 – Supplemental material for Thanks, but No Thanks: Unpacking the Relationship Between Relative Power and Gratitude
Creators: name: Anicich, Eric M.
name: Lee, Alice J.
name: Liu, Shi
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-docx-1-psp-10.1177_01461672211025945 for Thanks, but No Thanks: Unpacking the Relationship Between Relative Power and Gratitude by Eric M. Anicich, Alice J. Lee and Shi Liu in Personality and Social Psychology Bulletin
Additional file 1 of Multivariate genome-wide associations for immune traits in two maternal pig lines
Creators: name: Roth, Katharina
name: Pröll-Cornelissen, Maren Julia
name: Henne, Hubert
name: Appel, Anne Kathrin
name: Schellander, Karl
name: Tholen, Ernst
name: Große-Brinkhaus, Christine
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 1
sj-pdf-1-std-10.1177_09564624211032796 – Supplemental Material for Feasibility of implementing a same-day electronic screening tool for clinical assessment to measure patient-reported outcomes for eliciting actionable information on adherence to HIV medication and related factors in a busy Canadian urban HIV clinic
Creators: name: Suri, Shivali
name: Yoong, Deborah
name: Short, Duncan
name: Tan, Darrell HS
name: Naccarato, Mark
name: Crane, Heidi M
name: Musten, Alexandra
name: Fredericksen, Rob J
name: Lober, William B
name: Gough, Kevin
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplemental Material, sj-pdf-1-std-10.1177_09564624211032796 for Feasibility of implementing a same-day electronic screening tool for clinical assessment to measure patient-reported outcomes for eliciting actionable information on adherence to HIV medication and related factors in a busy Canadian urban HIV clinic by Shivali Suri, Deborah Yoong, Duncan Short, Darrell HS Tan, Mark Naccarato, Heidi M Crane, Alexandra Musten, Rob J Fredericksen, William B Lober and Kevin Gough in International Journal of STD & AIDS
VISUAL ANALYTICS AND INTERACTIVE MACHINE LEARNING FOR HUMAN BRAIN DATA
Creators: name: Li, Huang
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Computer graphics
Software engineering not elsewhere classified

description: This research focuses on using visualization techniques to help neuroscientists in understanding, developing and applying better machine learning models with human brain data.We built a software platform for multi-modal visualization and then apply advance techniques to interactively train a machine learning model with fewer data. We also proposed a method to visualize the features captured by the hidden layers in deep neural networks.
sj-pdf-1-fai-10.1177_10711007211031218 – Supplemental material for Clinical and Radiographic Outcomes of Percutaneous Chevron-Akin Osteotomies for the Correction of Hallux Valgus Deformity
Creators: name: Mikhail, Christopher M.
name: Markowitz, Jonathan
name: Di Lenarda, Luca
name: Guzman, Javier
name: Vulcano, Ettore
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental material, sj-pdf-1-fai-10.1177_10711007211031218 for Clinical and Radiographic Outcomes of Percutaneous Chevron-Akin Osteotomies for the Correction of Hallux Valgus Deformity by Christopher M. Mikhail, Jonathan Markowitz, Luca Di Lenarda, Javier Guzman and Ettore Vulcano in Foot & Ankle International
FSME: Risikogebiete in Deutschland (Stand: April 2017)
Creators: name: Koch-Institut, Robert
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2017
Subjects: subject: FSME
subject: Risikogebiete
subject: 610 Medizin

description: In dieser Ausgabe des Epidemiologischen Bulletins wird – in Übereinstimmung mit den diesbezüglichen Ausführungen in den Empfehlungen der Ständigen Impfkommission am RKI (STIKO) – eine aktualisierte Darstellung der Risikogebiete der Frühsommer-Meningoenzephalitis (FSME) in Deutschland in einer Einteilung nach Kreisgebieten als Grundlage für gezielte präventive Maßnahmen publiziert. Sie beruht auf den gemäß Infektionsschutzgesetz (IfSG) dem Robert Koch-Institut (RKI) übermittelten FSME-Erkrankungsdaten aus den Jahren 2002 bis 2016. Diese Karte ersetzt die Karte der Risikogebiete vom Mai 2016.
MPA Portable: A Stand-Alone Software Package for Analyzing Metaproteome Samples on the Go
Creators: name: Muth, Thilo
name: Kohrs, Fabian
name: Heyer, Robert
name: Benndorf, Dirk
name: Rapp, Erdmann
name: Reichl, Udo
name: Martens, Lennart
name: Renard, Bernhard Y.
Publisher: name: Robert Koch-Institut
Year: 2017
Subjects: subject: 610 Medizin

description: Metaproteomics, the mass spectrometry-based analysis of proteins from multispecies samples faces severe challenges concerning data analysis and results interpretation. To overcome these shortcomings, we here introduce the MetaProteomeAnalyzer (MPA) Portable software. In contrast to the original server-based MPA application, this newly developed tool no longer requires computational expertise for installation and is now independent of any relational database system. In addition, MPA Portable now supports state-of-theart database search engines and a convenient command line interface for highperformance data processing tasks. While search engine results can easily be combined to increase the protein identification yield, an additional two-step workflow is implemented to provide sufficient analysis resolution for further postprocessing steps, such as protein grouping as well as taxonomic and functional annotation. Our new application has been developed with a focus on intuitive usability, adherence to data standards, and adaptation to Web-based workflow platforms. The open source software package can be found at https://github.com/compomics/meta-proteomeanalyzer.
Tularemia in Germany—A Re-emerging Zoonosis
Creators: name: Faber, Mirko
name: Heuner, Klaus
name: Jacob, Daniela
name: Grunow, Roland
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie; Robert Koch-Institut, Biologische Sicherheit
Year: 2018
Subjects: subject: 610 Medizin

description: Tularemia, also known as “rabbit fever,” is a zoonosis caused by the facultative intracellular, gram-negative bacterium Francisella tularensis. Infection occurs through contact with infected animals (often hares), arthropod vectors (such as ticks or deer flies), inhalation of contaminated dust or through contaminated food and water. In this review, we would like to provide an overview of the current epidemiological situation in Germany using published studies and case reports, an analysis of recent surveillance data and our own experience from the laboratory diagnostics, and investigation of cases. While in Germany tularemia is a rarely reported disease, there is evidence of recent re-emergence. We also describe some peculiarities that were observed in Germany, such as a broad genetic diversity, and a recently discovered new genus of Francisella and protracted or severe clinical courses of infections with the subspecies holarctica. Because tularemia is a zoonosis, we also touch upon the situation in the animal reservoir and one-health aspects of this disease. Apparently, many pieces of the puzzle need to be found and put into place before the complex interaction between wildlife, the environment and humans are fully understood. Funding for investigations into rare diseases is scarce. Therefore, combining efforts in several countries in the framework of international projects may be necessary to advance further our understanding of this serious but also scientifically interesting disease.
A High Affinity Extracellular ATP Sensor for Studying Purinergic Signaling
Creators: name: Cholger, Daniel
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Biochemistry and cell biology not elsewhere classified

description: Adenosine Triphosphate (ATP) can be released as a signal between cells in an autocrine and paracrine manner that binds purinergic receptors. Highly conserved, purinergic receptors expressed on the cell surface of neurons and astrocytes are capable of being activated across eight orders of magnitude from hundreds of nanomolar ATP to millimolar. Genetically encoded fluorescent protein biosensors have been used to detect ATP outside the cell, but a high affinity extracellular ATP sensor is required to study the ATP signaling dynamics from nanomolar to micromolar magnitudes. Previously, our lab developed a first generation sensor of extracellular ATP called ECATS1 (Conley et al.). To develop an improved sensor, we caried out site-directed mutagenesis of the sensor's ATP binding site and identified a mutant that exhibited a 4-fold increase in ATP binding affinity in solution. We then optimized the membrane-tethering of the sensor to achieve the 4-fold increase in extracellular ATP binding affinity when measured on live cell.s This second-generation sensor was dubbed ECATS2. As a proof-of-concept application, we sought to detect ATP release from cells using in vitro models of edema. We subjected HEK293A cells to hypo-osmotic shock (HOS), revealing ATP release at micromolar levels. Then we tested HOS in cultured cortical astrocytes, also revealing micromolar ATP release. However, when we tested neuron-astrocyte co-cultures, we no longer observed ATP release in response to HOS. Interestingly, this implies that co-culture either entirely prevented ATP release from astrocytes or dampened it into the nanomolar range below the limit of ECATS2 detection. Thus, we have validated the development of a higher affinity, second-generation sensor and used it to discover that ATP release from astrocytes after HOS can be affected by the presence of neurons.
Biphasic Dispersion Fuels for High Performance Hybrid Propulsion
Creators: name: Mathews, Joshua D
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Aerospace engineering not elsewhere classified

description: This thesis describes a novel approach to augmenting the combustion performance of hybrid rocket fuels, specifically in terms of regression rate and combustion efficiency. Liquid additives are emulsified into molten paraffin wax using nonionic surfactants and cured to form cylindrical fuel grains. Fuel grains were tested in a lab scale, optically accessible hybrid rocket motor and compared to the performance of neat paraffin fuel grains.
Additional file 1 of Overall morbidity after total minimally invasive keyhole oesophagectomy versus hybrid oesophagectomy (the MICkey trial): study protocol for a multicentre randomized controlled trial
Creators: name: Klotz, Rosa
name: Diener, Markus K.
name: Schmidt, Thomas
name: Hackert, Thilo
name: Graf, Sandra
name: Fuchs, Hans F.
name: Grimminger, Peter
name: Egberts, Jan-Hendrick
name: Gockel, Ines
name: van der Sluis, Pieter C.
name: Doerr-Harim, Colette
name: Klose, Christina
name: Feißt, Manuel
name: Mihaljevic, Andre L.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Supplement 1. A list of study sites.
sj-docx-2-msj-10.1177_13524585211030212 – Supplemental material for Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study
Creators: name: Høgestøl, Einar August
name: Ghezzo, Samuele
name: Nygaard, Gro Owren
name: Espeseth, Thomas
name: Sowa, Piotr
name: Beyer, Mona K
name: Harbo, Hanne Flinstad
name: Westlye, Lars T
name: Hulst, Hanneke E
name: Alnæs, Dag
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, sj-docx-2-msj-10.1177_13524585211030212 for Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study by Einar August Høgestøl, Samuele Ghezzo, Gro Owren Nygaard, Thomas Espeseth, Piotr Sowa, Mona K Beyer, Hanne Flinstad Harbo, Lars T Westlye, Hanneke E Hulst and Dag Alnæs in Multiple Sclerosis Journal
sj-pdf-1-jcb-10.1177_0271678X211033358 - Supplemental material for Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep
Creators: name: Vallianatou, Theodosia
name: Lin, Weifeng
name: Bèchet, Nicholas B
name: Correia, Mario SP
name: Shanbhag, Nagesh C
name: Lundgaard, Iben
name: Globisch, Daniel
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 110306 Endocrinology
subject: Medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: 110320 Radiology and Organ Imaging
subject: Cell Biology
subject: Biochemistry
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Neuroscience

description: Supplemental material, sj-pdf-1-jcb-10.1177_0271678X211033358 for Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep by Theodosia Vallianatou, Weifeng Lin, Nicholas B Bèchet, Mario SP Correia, Nagesh C Shanbhag, Iben Lundgaard and Daniel Globisch in Journal of Cerebral Blood Flow & Metabolism
Miravitlles, Francesc (ed.) (1996). «Primo LEVI, Si això és un home»
Creators: name: Ardolino, Francesco
Publisher: name: Humanities Commons
Year: 1997
Subjects: subject: Italian literature
subject: Italian literature--Jewish authors
subject: Jewish Holocaust (1939-1945)
subject: Translating and interpreting

description: Review of Primo Levi, 'Si això és un home'
Additional file 1 of General versus central adiposity as risk factors for cardiovascular-related outcomes in a high-risk population with type 2 diabetes: a post hoc analysis of the REWIND trial
Creators: name: Franek, Edward
name: Pais, Prem
name: Basile, Jan
name: Nicolay, Claudia
name: Raha, Sohini
name: Hickey, Ana
name: Ahmad, Nadia N.
name: Konig, Manige
name: Kan, Hong
name: Gerstein, Hertzel C.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 1: Figure S1. Percentage of participants in the baseline Normal or Obese WC category in each BMI category. Figure S2. Association of BMI, WHR, WC, an WC adjusted for HC with (A) MACE-3, (B) CVD-related mortality, (C) all-cause mortality, and (D) HF requiring hospitalization or urgent care, minimally adjusted for age and sex (Step 1 of the statistical analysis approach). Table S1. Significant baseline characteristics used as additional risk factors to adjust for obesity measures.
Spectroscopic Investigation of a Novel Traumatic Brain Injury Biomarker and Analysis of Neurometabolic Changes in Youth American Football Athletes
Creators: name: Vike, Nicole L
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Neurosciences not elsewhere classified

description: Recent advances in Magnetic Resonance Imaging (MRI), a noninvasive imaging technique, have spurred the exploration of poorly understood physiological phenomena in vivo. Applications of MRI vary greatly, from anatomical evaluation to complex functional analysis. The body of this dissertation presents four applications of MRI: 1) investigation of a novel traumatic brain injury (TBI) biomarker, 2) analysis of position-specific head acceleration events on neurometabolic profiles in high school football athletes, 3) the first reporting of neurometabolic changes in middle school football athletes, and 4) a novel application of diffusion-weighted imaging (DWI) to characterize implantable drug-delivery depots (Appendix A). Magnetic resonance spectroscopy (MRS) is an MRI method used to evaluate the metabolic profiles of tissues. Certain brain metabolites (N-acetyl aspartate, myo-inositol, choline, creatine, and glutamate/glutamine) offer unique information regarding brain homeostasis following TBI. When coupled with additional metrics, such as head acceleration events recorded during collision-sport participation, the mechanisms of neurophysiological changes can be further elucidated. Here, player position-specific neurometabolic changes were evaluated in high school and middle school football athletes. Striking differences were noted between linemen and non-linemen as well as high school and middle school athletes. However, in most clinical cases of TBI, information regarding head acceleration events is unknown and baseline scans are not available.Therefore, it is critical to evaluate candidate biomarkers which increase solely in response to injury. Acrolein, a toxic reactive oxygen species, has been shown to increase following injury to the central nervous system in animal models. Hence, acrolein is a prime TBI biomarker candidate and has been investigated using nuclear magnetic resonance and MRS at 7 Tesla. Applications of MRI are not limited to the brain, or even tissues. Studies have reported that up to 50% of patients fail to take their medications correctly - resulting in disease progression and medication waste. In situ forming implants (ISFIs) offer an alternative to oral dosage regimens but have not been validated in vivo. Using DWI, ISFIs can be characterized noninvasively and their design can be refined, ultimately improving patient outcomes. Taken together, MRI is powerful tool that can be used to investigate a wide range of physiological questions. Chapters 2-4 will emphasize efforts to improve TBI diagnostics and better understand neurometabolic changes in youth football athletes. Appendix A offers insights into the DWI-guided characterization of in situ forming implants.
Additional file 1 of Multi-omics and experimental analysis unveil theragnostic value and immunological roles of inner membrane mitochondrial protein (IMMT) in breast cancer
Creators: name: Lin, Hung-Yu
name: Wu, Hsing-Ju
name: Chu, Pei-Yi
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 1: Figure S1. IMMT knockdown inhibits migration and induces lipid peroxidation in MCF-7 cells. Representative images of wound healing assay at 0 h and 22 h (A). Quantification line plot of the wound area determined by the migrated cells (B). *p < 0.05. Representative western blot of lipid peroxidation assessment by probing 4-HNE abundance. β-actin as loading control (C). Quantitative bar chart of 4-HNE abundance (D). Figure S2. Kaplan-Meier analysis of overall survival probability based on low/high IHC score of IMMT in BC patients with grade 3.
Statistical Learning and Model Criticism for Networks and Point Processes
Creators: name: Yang, Jiasen
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Statistics not elsewhere classified

description: Networks and point processes provide flexible tools for representing and modeling complex dependencies in data arising from various social and physical domains. Graphs, or networks, encode relational dependencies between entities, while point processes characterize temporal or spatial interactions among events.
In the first part of this dissertation, we consider dynamic network data (such as communication networks) in which links connecting pairs of nodes appear continuously over time. We propose latent space point process models to capture two different aspects of the data: (i) communication occurs at a higher rate between individuals with similar latent attributes (i.e., homophily); and (ii) individuals tend to reciprocate communications from others, but in a varied manner. Our framework marries ideas from point process models, including Poisson and Hawkes processes, with ideas from latent space models of static networks. We evaluate our models on several real-world datasets and show that a dual latent space model, which accounts for heterogeneity in both homophily and reciprocity, significantly improves performance in various link prediction and network embedding tasks.
In the second part of this dissertation, we develop nonparametric goodness-of-fit tests for discrete distributions and point processes that contain intractable normalization constants, providing the first generally applicable and computationally feasible approaches under those circumstances. Specifically, we propose and characterize Stein operators for discrete distributions, and construct a general Stein operator for point processes using the Papangelou conditional intensity function. Based on the proposed Stein operators, we establish kernelized Stein discrepancy measures for discrete distributions and point processes, which enable us to develop nonparametric goodness-of-fit tests for un-normalized density/intensity functions. We apply the kernelized Stein discrepancy tests to discrete distributions (including network models) as well as temporal and spatial point processes. Our experiments demonstrate that the proposed tests typically outperform two-sample tests based on the maximum mean discrepancy, which, unlike our goodness-of-fit tests, assume the availability of exact samples from the null model.
Additional file 1 of ECM stiffness affects cargo sorting into MSC-EVs to regulate their secretion and uptake behaviors
Creators: name: Liu, Zhixiao
name: Liu, Yingying
name: Li, Yu
name: Xu, Sha
name: Wang, Yang
name: Zhu, Yuruchen
name: Jiang, Chu
name: Wang, Kaizhe
name: Zhang, Yinan
name: Wang, Yue
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology

description: Additional file 1: Figure S1. The concentrations and average particle sizes of EVs obtained by NTA. Figure S2. Characterization of EVs using nano-flow cytometry. A, B The SSC distribution histograms of EVs. Figure S3. COG/KOG classification of UMSC cellular proteins regulated by substrate stiffness. Figure S4. Substrate stiffness regulates the localization of proteins within the UMSCs. GO enrichment of UMSC proteins regulated by substrate stiffness. COG/KOG classification of UMSC proteins regulated by substrate stiffness. Figure S5. COG classification of down-regulated proteins in soft-EVs. Figure S6. GO classification of differentially expressed miRNA-targeting genes.
sj-pdf-1-jtr-10.1177_00472875211028321 – Supplemental material for Do Regional Trade Agreements Enhance International Tourism Flows? Evidence from a Cross-Country Analysis
Creators: name: Khalid, Usman
name: Okafor, Luke Emeka
name: Burzynska, Katarzyna
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business
subject: 150402 Hospitality Management

description: Supplemental material, sj-pdf-1-jtr-10.1177_00472875211028321 for Do Regional Trade Agreements Enhance International Tourism Flows? Evidence from a Cross-Country Analysis by Usman Khalid, Luke Emeka Okafor and Katarzyna Burzynska in Journal of Travel Research
The Stories of Complicated Grievers: An Examination of the Effects of Complicated Grieving on the Narratives People Create After Experiencing the Loss of a Romantic Relationship
Creators: name: Donovan, Caitie
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Communication studies

description: The purpose of this study was to examine the ways in which the narratives told by people after a serious relationship dissolution are affected by the type of grief they experience. It was based on the current literature surrounding relationship dissolution and the resulting grief that comes from the loss of partner and relationship. The terms complicated grief and healthy grief were discussed; the emerging adult demographic and the particular ways in which grief is affected by extreme emotional situations were examined. Using the ideas presented in narrative inquiry and narrative therapy as a lens, data were qualitatively collected on twenty-two 18-24-year-old college students at a large Midwestern University. The study employed interviews and thematic coding to examine similarities and differences between complicated and healthy grievers. Practical suggestions were offered as to how complicated grievers could be guided to create narratives that make them better able to place blame appropriately, less likely to feel alone, and more willing to let go of their ex-partner.
That's (Also) Racist! Entity Type Pluralism, Responsibility, and Liberatory Norms
Creators: name: Davidson, Lacey J
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Philosophy not elsewhere classified

description: Some philosophers (Blum 2002 and Anderson 2010) have argued that ‘racism’ and ‘racist’ have been used so widely that they have lost their conceptual potency and are no longer effective moral evaluations. For this reason, they think we should use other terms to identify racial injustices. It is the goal of this dissertation to argue against this conclusion. In Chapter 2, I develop tools for diagnosing the individualist versus structuralist debate within philosophical accounts of racism. I use these tools to show that both individualists and structuralists are committed to entity type monism or the view that only certain kinds of entities can be racist. I reject this view and argue for entity type pluralism. In Chapter 3, I move from entity type pluralism to develop an account of the application conditions for the predicate ‘racist’ that tell us when and why we should apply the predicate to particular entities. These two chapters serve to clarify RACISM. In Chapter 4, I develop new resources for understanding moral responsibility for racism, specifically for how agents can be held accountable for intervening upon racist non-agential entities like norms, policies, and institutions. I call these resources “oblique blame” and “intervention-sensitive moral responsibility.” Intervention-sensitive moral responsibility gives way to a problem. Given the ways in which our current epistemic practices exclude the testimony of People of Color, we will have a hard time knowing when we are responsible in this intervention-sensitive way. I call this the Knowledge Problem. In Chapter 5, I bring together the literature on epistemic oppression and the empirically-informed norms literature to show that interventions into epistemic norms help solve this problem. I provide four candidate norms from activist and organizing communities as examples. Taken together, this dissertation shows that we need not discontinue our use of ‘racism’ and ‘racist’ and that the terms can be used effectively to hold each other accountable toward anti-racist aims and a liberated future.
100 m modelling and observations of  Berlin during 4 August 2022 heatwave
Creators: name: Glazer, Russell
name: Grimmond, Sue
name: Blunn, Lewis
name: Lean, Humphrey
name: Fenner, Daniel
name: Christen, Andreas
name: Morrison, William
name: Clements, Matthew
name: Meier, Fred
name: Barlow, Janet
Publisher: name: Zenodo
Year: 2023

description: WMO Paris RDP 

Unified Model  modelling
Just (not) doing my job: The moral imperativeness and aspiration of task execution
Creators: name: Ng, Vincent L
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Industrial and organisational psychology (incl. human factors)

description: Drawing from literature on job performance, moral intensity (Jones, 1991), and job characteristics theory (Grant, Fried, & Juillerat, 2011; Hackman & Oldham, 1976; Oldham & Fried, 2016), I propose a core feature of work that is not currently recognized or studied in extant work design research: the degree of moral imperativeness and aspiration. That is, jobs differ in how much their performance (i.e., task execution) is a moral imperative or aspiration. I first distinguish the moral imperativeness and aspiration of task execution (MITE and MATE) from related concepts such as task significance (Hackman & Oldham, 1975), prosocial characteristics of work (Grant, 2007, 2008a), and moral intensity of a task (Opoku-Dakwa, 2017, 2018). I then develop and validate a scale. In Study 1, I used job incumbents to provide empirical support that moral imperativeness and aspiration of task execution is distinguishable from related constructs, converge with theoretically-relevant constructs, and predict work criteria as experienced by job incumbents. In Study 2, I used naïve raters to judge the moral imperativeness and aspiration of work tasks at the task level to provide further evidence that they tap objective aspects of occupations.
Analysis of mutations in pncA reveals non-overlapping patterns among various lineages of Mycobacterium tuberculosis
Creators: name: Baddam, Ramani
name: Kumar, Narender
name: Wieler, Lothar H.
name: Lankapalli, Aditya Kumar
name: Ahmed, Niyaz
name: Peacock, Sharon J.
name: Semmler, Torsten
Publisher: name: Robert Koch-Institut
Year: 2018
Subjects: subject: 610 Medizin

description: Pyrazinamide (PZA) is an important first-line anti-tuberculosis drug, resistance to which occurs primarily due to mutations in pncA (Rv2043c) that encodes the pyrazinamidase enzyme responsible for conversion of pro-drug PZA into its active form. Previous studies have reported numerous resistance-conferring mutations distributed across the entire length of pncA without any hotspot regions. As different lineages of Mycobacterium tuberculosis display a strong geographic association, we sought to understand whether the genetic background influenced the distribution of mutations in pncA. We analyzed the whole genome sequence data of 1,480 clinical isolates representing four major M. tuberculosis lineages to identify the distribution of mutations in the complete operon (Rv2044c-pncA-Rv2042c) and its upstream promoter region. We observed a non-overlapping pattern of mutations among various lineages and identified a lineage 3-specific frame-shift deletion in gene Rv2044c upstream of pncA that disrupted the stop codon and led to its fusion with pncA. This resulted in the addition of a novel domain of unknown function (DUF2784) to the pyrazinamidase enzyme. The variant molecule was computationally modelled and physico-chemical parameters determined to ascertain stability. Although the functional impact of this mutation remains unknown, its lineage specific nature highlights the importance of genetic background and warrants further study.
Additional file 1 of Hip-specific and generic patient-reported outcome measure scores after primary hip replacement are associated with early revision surgery: a national registry study
Creators: name: Ackerman, Ilana N.
name: Cashman, Kara
name: Lorimer, Michelle
name: Heath, Emma
name: Harris, Ian A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Mental Health

description: Supplementary Material 1
Population Genomics of Kirtland’s Snake (Clonophis kirtlandii)
Creators: name: Noland, Alanna D
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Anthropological genetics
Genetics not elsewhere classified
Behavioural genetics

description: The semi-fossorial Kirtland’s Snake Clonophis kirtlandii is a relatively small species in the subfamily Natricinae that is endemic to the Midwest and prefers moist habitats such as open meadows and wetlands. Threatened or endangered over most of its range, a population genomic study for this species is necessary to better understand the status of its populations and provide a basis for developing management plans to further its protection. Here, a population genomics analysis using 3RAD was used to discover 166 SNPs within this species from across its geographic range. Multiple cluster analyses revealed populations formed three clusters, which were not clearly based on geographic location. Samples from Indiana and Ohio showed admixture and were assigned to two different clusters, while Illinois samples were all located in a single cluster. Michigan samples and some individuals collected from single site in southeast Indiana formed a third distinct cluster. Pairwise comparison of DAPC results revealed that the three identified clusters were distinct from each other. Individuals from non-urban habitats trended toward higher levels of nucleotide diversity and expected heterozygosity compared to individuals from urban habitats but without statistical support. This study successfully identified loci that were used to describe genetic variation between C. kirtlandii populations.
Analysis of TNT, DNA Methylation, and Hair Pigmentation via Gas Chromatography-Mass Spectrometry and Spectroscopic Techniques
Creators: name: Ruchti, Jacqueline Syra
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Forensic chemistry

description: This work consisted of three projects. The first focused on analyzing TNT residue collected from post-blast backpack debris with an M-Vac. The second focused on analyzing DNA methylation in blowflies to determine a post-mortem interval based on the blowfly's age. The third focused on analyzing hair pigmentation to build a statistical database to further support evidence presented in court.
title: Kernkompetenzen professioneller Gesundheitsförderung
Creators: name: Biel, Verena
name: Göpel, Eberhard
Publisher: name: Bundeszentrale für gesundheitliche Aufklärung
Year: 2024

description: Leitbegriffe der Gesundheitsförderung und Prävention. Glossar zu Konzepten, Strategien und Methoden.
Supplemental Material, sj-pdf-1-tor-10.1177_23978473211021072 - Thirteen-week nose-only inhalation exposures of propylene glycol aerosols in Sprague Dawley rats with a lung systems toxicology analysis
Creators: name: Langston, T
name: Randazzo, J
name: Kogel, U
name: Hoeng, J
name: Martin, F
name: Titz, B
name: Guedj, E
name: Schneider, T
name: Prabhakar, B
name: Zhang, J
name: Oldham, M
name: Lee, KM
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Supplemental Material, sj-pdf-1-tor-10.1177_23978473211021072 for Thirteen-week nose-only inhalation exposures of propylene glycol aerosols in Sprague Dawley rats with a lung systems toxicology analysis by T Langston, J Randazzo, U Kogel, J Hoeng, F Martin, B Titz, E Guedj, T Schneider, B Prabhakar, J Zhang, M Oldham and KM Lee in Toxicology Research and Application
THE INFLUENCE OF MUSIC FESTIVAL EXPERIENCE ON DESTINATION IMAGE AND FESTIVAL IMAGE.pdf
Creators: name: Mosley, Matthew Corey
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Impacts of tourism
Hospitality management
Tourism not elsewhere classified

description: The purpose of this study is to explore how attending a blues music festival can influence an attendees image of the destination, the image of the festival and their intention to return. Predicting attendee behavior intentions have been a constant focus of academics and festival organizers. It has been shown that the festival environment (venue and facilities) are influential, that positive interactions with festival staff and vendors affect attendee satisfaction and depending on the study the aspect surrounding the musical performance can influence future behavior. This study has incorporated an area previously found to be important to attendee satisfaction but so far has not been studied with the other aspects of how a festival performs. This study investigated the influence of those four factors (venue, services, core product and safety) on attendees’ perception of their satisfaction with the festival and the subsequent influence on their image of the destination and festival.