cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Exploring Felix Klein's contested modernism
Creators: name: Heinig, Peter
name: Katz, Mikhail G.
name: Kuhlemann, Karl
name: Schaefermeyer, Jan Peter
name: Sherry, David
Publisher: name: arXiv
Year: 2024
Subjects: subject: History and Overview (math.HO)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 01A60, 01A61

description: An alleged opposition between David Hilbert and Felix Klein as modern vs countermodern has been pursued by marxist historian Herbert Mehrtens and others. Scholars such as Epple, Grattan-Guinness, Gray, Quinn, Rowe, and recently Siegmund-Schultze and Mazzotti have voiced a range of opinions concerning Mehrtens' dialectical methodology. We explore contrasting perspectives on Klein's contested modernism, as well as Hilbert's and Klein's views on intuition, logic, and physics. We analyze Jeremy Gray's comment on Klein's ethnographic speculations concerning Jewish mathematicians and find it to be untenable. We argue that Mehrtens was looking for countermoderns at the wrong address.
description: 32 pages
Supplementary documentation for SAEON's field instrument data collected at the Cape Agulhas Rondepan station
Creators: name: South African Environmental Observation Network (SAEON) Fynbos Node
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: SAEON field instruments
Standard Operating Procedures
Calibration
Cape Agulhas
Hydrological
Solinst depth and temperature logger
water level
water temperature

description: This package contains supporting information for the hydrological data collected at Cape Agulhas's Rondepan station, as part of the South African Environmental Observation Network's monitoring projects.
Towards general patterns of features in multi-field inflation
Creators: name: Gao, Xian
name: Gong, Jinn-Ouk
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate the consequences of general curved trajectories in multi-field inflation. After setting up a completely general formalism using the mass basis, which naturally accommodates the notion of light and heavy modes, we study in detail the simple case of two successive turns in two-field system. We find the power spectrum of the curvature perturbation receives corrections that exhibit oscillatory features sinusoidal in the logarithm of the comoving wavenumber without slow-roll suppression. We show that this is because of the resonance of the heavy modes inside and outside the mass horizon.
description: (v1) 16 pages, 2 figures; (v2) 17 pages, minor updates, to appear in Journal of High Energy Physics
Häusliche Gewalt - Forschungsstand
Creators: name: Stahlke, Iris
Publisher: name: Verlag Barbara Budrich
Year: 2022
Subjects: subject: Häusliche Gewalt
subject: Psychosoziale Prozessbegleitung
subject: 150

description: Häusliche Gewalt hat viele Erscheinungsformen. Im vorliegenden Beitrag soll ein Überblick über den aktuellen Forschungsstand zum Phänomen der Häuslichen Gewalt im europäischen und insbesondere im deutschsprachigen Raum gegeben werden. Es wird im Weiteren auf Gewalthandlungen, -folgen und Unterstützungsangebote eingegangen. Es erfolgt eine Bezugnahme auf Psychosoziale Prozessbegleitung als Unterstützungsangebot für von Häuslicher Gewalt betroffene Menschen und im Fazit wird ein Ausblick auf mögliche Verbesserungen gegeben.
Prenatal Diagnosis
Creators: name: Carlson, Laura M.
name: Vora, Neeta L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The American Congress of Obstetricians and Gynecologists recommends that all pregnant women be offered aneuploidy screening or diagnostic testing. A myriad of screening and testing options are available to patients based on their risk profile and gestational age. Screening options include traditional serum analyte screening, such as first-trimester screening or quadruple screening, and more recently, cell-free DNA. Diagnostic testing choices include chorionic villus sampling and amniocentesis. The number of screening and diagnostic modalities complicates prenatal counseling for physicians and can be difficult for patients to grasp. Appropriate pretest and posttest counseling is important to ensure adequate understanding of results and ensure testing strategy is concordant with patient goals.
Optoelectronic System and Device Integration for Quantum-Dot Light-Emitting Diode White Lighting with Computational Design Framework
Creators: name: Samarakoon, Chatura
name: Choi, Hyung Woo
name: Lee, Sanghyo
name: Fan, Xiangbing
name: Shin, Dongwook
name: Bang, Sang Yun
name: Jo, Jeongwan
name: Ni, Limeng
name: Yang, Jiajie
name: Kim, Yoonwoo
name: Jung, Sungmin
name: Occhipinti, Luigi
name: Amaratunga, Gehan
name: Kim, Jong Min
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/639/166/987
/639/624/1020
/639/925/357/1017
/132
/119
article

description: We propose a computational design framework to design the architecture of a white lighting system having multiple pixelated patterns of electric-field-driven quantum dot light-emitting diodes. The quantum dot of the white lighting system has been optimised by a system-level combinatorial colour optimisation process with the Nelder-Mead algorithm used for machine learning. The layout of quantum dot patterns is designed precisely using rigorous device-level charge transport simulation with an electric-field dependent charge injection model. A theoretical maximum of 97% colour rendering index has been achieved with red, green, cyan, and blue quantum dot light-emitting diodes as primary colours. The white lighting system has been fabricated using the transfer printing technique to validate the computational design framework. It exhibits excellent lighting performance of 92% colour rendering index and wide colour temperature variation from 1612 K to 8903 K with only the four pixelated quantum dots as primary.
description: UK Engineering and Physical Sciences Research Council (EPSRC) project EP/P027628/1 Smart Flexible Quantum Dot Lighting’ and by the European Union under H2020 grant agreement No 685758 ‘1D-NEON’ EPSRC through the doctoral training partnership (DTP) scheme, studentship award EP/N509620/1
Numerical simulation of nonequilibrium states in a trapped Bose-Einstein condensate
Creators: name: Novikov, A. N.
name: Yukalov, V. I.
name: Bagnato, V. S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: In this work we present numerical study of a trapped Bose-Einstein condensate perturbed by an alternating potential. The relevant physical situation has been recently realized in experiment, where the trapped condensate of $^{87}$Rb, being strongly perturbed, exhibits the set of spatial structures. Firstly, regular vortices are detected. Further, increasing either the excitation amplitude or modulation time results in the transition to quantum vortex turbulence, followed by a granular state. Numerical simulation of the nonequilibrium Bose-condensed system is based on the solution of the time-dependent 3D nonlinear Schrödinger equation within the static and dynamical algorithms. The damped gradient step and time split-step Fourier transform methods are employed. We demonstrate that computer simulations qualitatively reproduce the experimental picture, and describe well the main experimental observables.
description: Latex file, 7 pages, 1 figure
Absicherung des Risikos der Pflegebedürftigkeit. Social protection for long-term care provision
Creators: name: Rothgang, Heinz
Publisher: name: DeGruyter
Year: 2018
Subjects: subject: Pflegebedürftigkeit
subject: Lebensrisiko
subject: Lebenszeitprävalenz
subject: 300

description: Pflegebedürftigkeit ist ein allgemeines Lebensrisiko mit einer Lebenszeitprävalenz von 57% bei Männern und 74% bei Frauen. Bis 1994 galt die Absicherung dieses Risikos als private Aufgabe mit lediglich der Sozialhilfe und der Kriegsopferfürsorge als letztes Netz. Seit Einführung der Pflegeversicherung im Jahr 1994 sind die öffentlichen Ausgaben für Pflegebedürftigkeit deutlich angestiegen. Dies hat nicht nur zu einer Reduktion pflegebedingter Sozialhilfeabhängigkeit, sondern auch zu einer quantitativen und qualitativen Verbesserung der Versorgungsstruktur geführt. Angesichts eines bereits fühlbaren in Zukunft aber noch deutlich steigen- den Pflegenotstands muss die Attraktivität des Pflegeberufs durch bessere Entlohnung und Verbesserung der Arbeitsbedingungen gefördert werden. Um mit den dazu erforderlichen Mehrausgaben nicht ausschließlich die Pflegebedürftigen zu belasten, ist eine Systemreform der Pflegeversicherungsfinanzierung wünschenswert.
Paper: Protea nectar and satellite fauna in relation to the food requirements and pollinating role of the Cape Sugarbird by D.P. Mostert and W.R. Siegfried and Gideon N. Louw
Creators: name: Gideon N. Louw
name: W.R. Siegfried
name: D.P. Mostert
Publisher: name: South African Journal of Science
Year: 2022
Subjects: Jonkershoek Forestry Research Centre
Protea nectar
Cape Sugarbird

description: This journal article, 'Protea nectar and satellite fauna in relation to the food requirements and pollinating role of the Cape Sugarbird' by D.P. Mostert and W.R. Siegfried and Gideon N. Louw forms part of the historical collection of papers from the Jonkershoek Forestry Research Center. The Jonkershoek Forestry Research Center (part of the former South African Forestry Research Institute) was established in 1935 at Jonkershoek, near Stellenbosch, under the directorship of Dr C. L. Wicht. The initial aim was to determine how forestry activities in state plantations would affect climate, water conservation and erosion, and was later expanded to include studies of fynbos ecology, fire and alien species. Studies from the 1930s to the early 1990s saw the accumulation of a large amount of data dealing with fire experiments, detailed vegetation plot surveys, rare plant surveys and ecological studies, hydrological studies and the development of management plans for catchments around the Western Cape. SAEON now houses the archive of data collected by the Jonkershoek Forestry Research Center, which was originally held by the Council for Scientific and Industrial Research (CSIR).
E pluribus, quaedam. Gross domestic product out of a dashboard of indicators
Creators: name: Guerini, Mattia
name: Vanni, Fabio
name: Napoletano, Mauro
name: Guerini, Mattia
name: Vanni, Fabio
name: Napoletano, Mauro
Publisher: name: Unknown
Year: 2022
Subjects: subject: Environmental Economics and Policy
subject: Labor and Human Capital
subject: Political Economy
subject: Production Economics
subject: Gross domestic product
subject: well-being indicators
subject: data reduction techniques
subject: principal component analysis
subject: random matrix

description: Is aggregate income enough to summarize the well-being of a society? We address this longstanding question by exploiting a novel approach to study the relationship between gross domestic product (GDP) and a set of economic, social and environmental indicators for nine developed economies. By employing dimensionality reduction techniques, we quantify the share of variability stemming from a large set of different indicators that can be compressed into a univariate index. We also evaluate how well this variability can be explained if the univariate index is GDP. Our results indicate that univariate measures, and GDP among them, are doomed to fail in accounting for the variability of well-being indicators. Even if GDP would be the best linear univariate index, its quality in synthesizing information from indicators belonging to different domains is poor. Our approach provides additional support for policy makers interested in measuring the trade offs between income and other relevant socio-economic and ecological dimensions. Furthermore, it adds new quantitative evidence to the already vast literature criticizing GDP as the most prominent measure of well-being.
Application of the envelope peaks over threshold (EPOT) method for probabilistic assessment of dynamic stability
Creators: name: Campbell, Bradley
name: Belenky, Vadim
name: Pipiras, Vladas
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: This paper reviews the research and development of the Envelope Peaks over Threshold (EPOT) method that has taken place in the last three years. The EPOT method is intended for the statistical extrapolation of ship motions and accelerations from time-domain numerical simulations, or possibly, from a model test. To model the relationship between probability and time, the large roll angle events must be independent, so Poisson flow can be used. The method uses the envelope of the signal to ensure the independence of large exceedances. The most significant development was application of the generalized Pareto Distribution (GPD) for approximation of the tail, replacing the previously used Weibull distribution. This paper reviews the main aspects of modeling the GPD, including its mathematical justification, fitting the parameters of the distribution, and evaluating the probability of exceedance and its confidence interval.
Von der Risiko- zur Anbieterselektion : Eigendynamiken wettbewerblicher Reformen in Gesundheitssystemen des Sozialversicherungstyps
Creators: name: Rothgang, Heinz
name: Götze, Ralf
name: Gacace, Mirella
Publisher: name: DeGruyter
Year: 2016
Subjects: subject: Sozialversicherung
subject: Risikoselektion
subject: Anbieterselektion
subject: Reformen
subject: 300

description: Seit den 1990er Jahren lässt sich in mehreren OECD-Gesundheitssystemen des Sozialversicherungstyps die Implementation wettbewerblicher Reformen beobachten. Ein Vergleich von Deutschland und den Niederlanden als zwei Vertretern dieses Typs zeigt, dass diese Reformen eine Eigendynamik entwickeln: Einmal in einem Teilsegment eingeführter Wettbewerb erfordert „mehr" Wettbewerb und Re-Regulierung. Von der freien Kassenwahl gingen in beiden Staaten zunächst steigende Anreise zur Risikoselektion aus. Um dieser Fehlentwicklung Einhalt zu gebieten, verbesserte der Gesetzgeber die Risikoadjustierung und eröffnete Möglichkeiten zur Anbieterselektion. Als Konsequenz wird das korporatistische Steuerungsmodell sukzessive durch Marktwettbewerb und staatliche Hierarchie ergänzt oder sogar substituiert.
Expressive Path Queries on Graph with Data
Creators: name: Barcelo, Pablo
name: Fontaine, Gaelle
name: Lin, Anthony Widjaja
Publisher: name: arXiv
Year: 2015
Subjects: subject: Databases (cs.DB)
subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: Graph data models have recently become popular owing to their applications, e.g., in social networks and the semantic web. Typical navigational query languages over graph databases - such as Conjunctive Regular Path Queries (CRPQs) - cannot express relevant properties of the interaction between the underlying data and the topology. Two languages have been recently proposed to overcome this problem: walk logic (WL) and regular expressions with memory (REM). In this paper, we begin by investigating fundamental properties of WL and REM, i.e., complexity of evaluation problems and expressive power. We first show that the data complexity of WL is nonelementary, which rules out its practicality. On the other hand, while REM has low data complexity, we point out that many natural data/topology properties of graphs expressible in WL cannot be expressed in REM. To this end, we propose register logic, an extension of REM, which we show to be able to express many natural graph properties expressible in WL, while at the same time preserving the elementariness of data complexity of REMs. It is also incomparable to WL in terms of expressive power.
description: 39 pages
The Role of Dispersants in Oil Spill Remediation: Fundamental Concepts, Rationale for Use, Fate, and Transport Issues
Creators: name: Field, Jennifer
name: Kujawinski, Elizabeth
name: John, Vijay
name: McCormick, Alon
name: Arnosti, Carol
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: ABSTRACTOffering a scientific perspective, this paper provides a rationale for the use of dispersants in oil spill remediation by discussing their formulations and modes of action and connecting their physics and chemistry to a their environmental fates and impacts. With the first use of dispersants at the source of the oil release during the Deepwater Horizon incident, there is a new great need for understanding the efficiency and the environmental impacts of their use. The paper concludes with some cautionary recommendations on dispersant research.
Predators, environment and host characteristics influence the probability of infection by an invasive castrating parasite
Creators: name: Hughes, A. Randall
name: Gehman, Alyssa-Lois M.
name: Grabowski, Jonathan H.
name: Kimbro, David L.
name: Byers, James E.
name: Piehler, Michael F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Not all hosts, communities or environments are equally hospitable for parasites. Direct and indirect interactions between parasites and their predators, competitors and the environment can influence variability in host exposure, susceptibility and subsequent infection, and these influences may vary across spatial scales. To determine the relative influences of abiotic, biotic and host characteristics on probability of infection across both local and estuary scales, we surveyed the oyster reef-dwelling mud crab Eurypanopeus depressus and its parasite Loxothylacus panopaei, an invasive castrating rhizocephalan, in a hierarchical design across >900 km of the southeastern USA. We quantified the density of hosts, predators of the parasite and host, the host's oyster reef habitat, and environmental variables that might affect the parasite either directly or indirectly on oyster reefs within 10 estuaries throughout this biogeographic range. Our analyses revealed that both between and within estuary-scale variation and host characteristics influenced L. panopaei prevalence. Several additional biotic and abiotic factors were positive predictors of infection, including predator abundance and the depth of water inundation over reefs at high tide. We demonstrate that in addition to host characteristics, biotic and abiotic community-level variables both serve as large-scale indicators of parasite dynamics.
title: On-chip frequency tuning of fast resonant MEMS scanner
Creators: name: Janin, Paul
name: Uttamchandani, Deepak
name: Bauer, Ralf
Publisher: name: Strathprints - University of Strathclyde
Year: 2022

description: The development and characterisation of a piezoelectric actuated high-frequency MEMS scanning mirror with on-chip frequency tuning capability is reported. The resonant scanner operates at frequencies in excess of 140 kHz, generating scan angles of 10 ∘ and 6 ∘ for two orthogonal movement modes with 40 V actuation. On-chip frequency tuning is achieved through electrothermal actuators fabricated adjacent to the mirror main suspension. The electrothermal actuators produce a global and local temperature increase which changes the suspension stiffness and therefore the resonant frequency. A resonance frequency tuning range of up to 5.5 kHz is achieved, with tuning dominant on only one of the two orthogonal scan movement modes. This opens the possibility for precise tuning of a 2D Lissajous scan pattern using a single resonant MEMS scanner with dual orthogonal resonant modes producing full frame update rates up to 20 kHz while retaining the full angular range of both resonant movement modes.
On uniqueness of Heine-Stieltjes polynomials for second order finite-difference equations
Creators: name: Moroz, Alexander
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 65L12

description: A second order finite-difference equation has two linearly independent solutions. It is shown here that, like in the continuous case, at most one of the two can be a polynomial solution. The uniqueness in the classical continuous Heine-Stieltjes theory is shown to hold under broader hypotheses than usually presented. A difference between regularity condition and uniqueness is emphasized. Consistency of our uniqueness results is also checked against one of the Shapiro problems. An intrinsic relation between the Heine-Stieltjes problem and the discrete Bethe Ansatz equations allows one to immediately extend the uniqueness result from the former to the latter. The results have implications for nondegeneracy of polynomial solutions of physical models.
description: 21 pages. A remark to Theorem 1 added
Liouville Quantum Gravity on the complex tori
Creators: name: David, François
name: Rhodes, Rémi
name: Vargas, Vincent
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 60D05, 81T40, 81T20

description: In this paper, we construct Liouville Quantum Field Theory (LQFT) on the toroidal topology in the spirit of the 1981 seminal work by Polyakov. Our approach follows the construction carried out by the authors together with A. Kupiainen in the case of the Riemann sphere. The difference is here that the moduli space for complex tori is non trivial. Modular properties of LQFT are thus investigated. This allows us to sum up the LQFT on complex tori over the moduli space, to compute the law of the random Liouville modulus, therefore recovering (and extending) formulae obtained by physicists, and make conjectures about the relationship with random planar maps of genus one, eventually weighted by a conformal field theory and conformally embedded onto the torus.
Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy
Creators: name: Thodeti,
name: Klagsbrun,
name: Ghosh,
name: Ingber,
name: Meszaros,
name: Cappelli,
name: Dudley,
name: Keshamouni,
name: Thoppil,
name: Chilian,
name: Paruchuri,
name: Adapala,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Tumor vessels are characterized by abnormal morphology and hyper-permeability that together cause inefficient delivery of chemotherapeutic agents. Although VEGF has been established as a critical regulator of tumor angiogenesis, the role of mechanical signaling in the regulation of tumor vasculature or tumor endothelial cell (TEC) function is not known. Here, we show that the mechanosensitive ion channel TRPV4 regulates tumor angiogenesis and tumor vessel maturation via modulation of TEC mechanosensitivity. We found that TEC exhibit reduced TRPV4 expression and function, which is correlated with aberrant mechanosensitivity towards ECM stiffness, increased migration and abnormal angiogenesis by TEC. Further, syngeneic tumor experiments revealed that the absence of TRPV4 induced increased vascular density, vessel diameter and reduced pericyte coverage resulting in enhanced tumor growth in TRPV4 KO mice. Importantly, overexpression or pharmacological activation of TRPV4 restored aberrant TEC mechanosensitivity, migration and normalized abnormal angiogenesis in vitro by modulating Rho activity. Finally, a small molecule activator of TRPV4, GSK1016790A, in combination with anti-cancer drug Cisplatin, significantly reduced tumor growth in WT mice by inducing vessel maturation. Our findings demonstrate TRPV4 channels to be critical regulators of tumor angiogenesis and represent a novel target for anti-angiogenic and vascular normalization therapies.
EGFR-targeted mAb therapy modulates autophagy in head and neck squamous cell carcinoma through NLRX1–TUFM protein complex
Creators: name: Ting,
name: Kansy,
name: Ouyang,
name: Cong,
name: Wen,
name: Ferris,
name: Li,
name: Lei,
name: Trivedi,
name: Liu,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: EGFR-targeted therapy in head and neck squamous cell carcinoma (HNSCC) patients frequently results in tumor resistance to treatment. Autophagy is an emerging underlying resistance mechanism, however, the molecular autophagy machinery in HNSCC cells and potential biomarkers of patient response to EGFR-targeted therapy remain insufficiently characterized. Here we show that the EGFR blocking with cetuximab leads to varied autophagic responses, which modulate cancer cell susceptibility to EGFR inhibition. Inhibition of autophagy sensitizes HNSCC cells to EGFR blockade. Importantly, we identify a novel signaling hub centering on the NLRX1-TUFM protein complex, promoting autophagic flux. Defects in the expression of either NLRX1 or TUFM result in compromised autophagy when treated with EGFR inhibitors. As a previously undefined autophagy-promoting mechanism, we found that TUFM serves as a novel anchorage site, recruiting Beclin-1 to mitochondria, promoting its polyubiquitination, and interfering with its interaction with Rubicon. This protein complex is also essential for endoplasmic reticulum (ER) stress signaling induction, possibly as an additional mechanism to promote autophagy. Utilizing tumor specimens from a novel neoadjuvant clinical trial, we show that increased expression of the autophagy adaptor protein, SQSTM1/p62, is associated with poor response to cetuximab therapy. These findings expand our understanding of the components involved in HNSCC autophagy machinery that responds to EGFR inhibitors, and suggest potential combinatorial approaches to enhance its therapeutic efficacy.
title: Moving spaces: choreography, metaphor and meaning
Creators: name: Newman, Rosalind
Publisher: name: University of Kent
Year: 2022

description: Space is as integral to choreography as time, energy, and the body in motion. In this dissertation, Moving Spaces: Choreography, Metaphor, and Meaning, I ask how choreographic space acquires meaning, consider the kinds of meanings it conveys, and discover where those meanings are located within a dance. I explore, then, the ways our perceptions of space are influenced by culture, personal experience, and biology, and question to what degree our responses are universal or unique. I reflect on and analyse a selection of my choreographic work, view the work of other choreographers, and draw on the writings of scholars in dance and other disciplines to describe and think through my dances. I investigate these writers’ views on dance, space, meaning, and the body in motion and link them to my practical research. I see the views and theories of four scholars as particularly significant: Gaston Bachelard’s insights about imagination and metaphor, and how art reflects our sense of intimate space; Rudolf Laban’s notions of spatial geometry and the interconnections between space, time, and force; Ivar Hagendoorn’s discussions of neurological research, which offer insights into both the creation and perception of space in dance; and, Yi Fu Tuan’s illuminating ideas about the cultural influences on our experiences of space and place. I consider the meaning of space in my dances, and examine how these works articulate my own cultural and personal experiences of growing up and living in New York City and as an expatriate in Hong Kong. Through this close reading of my choreography, and with an understanding that there are no universal terms for viewing space, I suggest the importance of taking into account a multifaceted approach to understanding space in dance, including the reflections and insights of artists.
Soil Moisture retention curves in Hottentots Holland, Jakkalsrivier Catchment
Creators: name: Jonkershoek Forestry Research Center
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: Jonkershoek Forestry Research Centre
Hottentots Holland
soil moisture
Jakkalsrivier

description: This is a scanned copy of a document on soil moisture retention curves in Hottentots Holland, Jakkalsrivier Catchment. The Jonkershoek Forestry Research Center (part of the former South African Forestry Research Institute) was established in 1935 at Jonkershoek, near Stellenbosch, under the directorship of Dr C. L. Wicht. The initial aim was to determine how forestry activities in state plantations would affect climate, water conservation and erosion, and was later expanded to include studies of fynbos ecology, fire and alien species. Studies from the 1930s to the early 1990s saw the accumulation of a large amount of data dealing with fire experiments, detailed vegetation plot surveys, rare plant surveys and ecological studies, hydrological studies and the development of management plans for catchments around the Western Cape.  SAEON now houses the archive of data collected by the Jonkershoek Forestry Research Center, which was originally held by the Council for Scientific and Industrial Research (CSIR).
Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression
Creators: name: Zhang,
name: Pradeep,
name: Rodriguez-Aguayo,
name: Previs,
name: Calin,
name: Lopez-Berestein,
name: McGuire,
name: Yang,
name: Ivan,
name: Nagaraja,
name: Huang,
name: Pecot,
name: Wu,
name: Sood,
name: Armaiz-Pena,
name: Bar-Eli,
name: Mangala,
name: Gharpure,
name: Rupaimoole,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: MicroRNAs (miRNAs) are small RNA molecules that affect cellular processes by controlling gene expression. Recent studies have shown that hypoxia downregulates Drosha and Dicer, key enzymes in miRNA biogenesis, causing a decreased pool of miRNAs in cancer, and resulting in increased tumor growth and metastasis. Here, we demonstrate a previously unrecognized mechanism by which hypoxia downregulates Dicer. We found that miR-630, which is upregulated under hypoxic conditions, targets and downregulates Dicer expression. In an orthotopic mouse model of ovarian cancer, delivery of miR-630 using DOPC nanoliposomes resulted in increased tumor growth and metastasis and decreased Dicer expression. Treatment with the combination of anti-miR-630 and anti-vascular endothelial growth factor antibody in mice resulted in rescue of Dicer expression and significantly decreased tumor growth and metastasis. These results indicate that targeting miR-630 is a promising approach to overcome Dicer deregulation in cancer. As demonstrated in the study, use of DOPC nanoliposomes for anti-miR delivery serves as a better alternative approach to cell line based overexpression of sense or anti-sense miRNAs, while avoiding potential in vitro selection effects. Findings from this study provide a new understanding of miRNA biogenesis downregulation observed under hypoxia and suggest therapeutic avenues to target this dysregulation in cancer.
Litho-dendrograph - Swartboskloof in Jonkershoek
Creators: name: Jonkershoek Forestry Research Center
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: Jonkershoek Forestry Research Centre
Litho-dendrograph
Swartboskloof
Jonkershoek

description: This is a scanned copy of a document, including a photograph, of a litho-dendrograph from Swartboskloof in Jonkershoek. The Jonkershoek Forestry Research Center (part of the former South African Forestry Research Institute) was established in 1935 at Jonkershoek, near Stellenbosch, under the directorship of Dr C. L. Wicht. The initial aim was to determine how forestry activities in state plantations would affect climate, water conservation and erosion, and was later expanded to include studies of fynbos ecology, fire and alien species. Studies from the 1930s to the early 1990s saw the accumulation of a large amount of data dealing with fire experiments, detailed vegetation plot surveys, rare plant surveys and ecological studies, hydrological studies and the development of management plans for catchments around the Western Cape. SAEON now houses the archive of data collected by the Jonkershoek Forestry Research Center, which was originally held by the Council for Scientific and Industrial Research (CSIR).
MDM2 oligomers: antagonizers of the guardian of the genome
Creators: name: Zhang,
name: Leslie,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Over two decades of MDM2 research has resulted in the accumulation of a wealth of knowledge of many aspects of MDM2 regulation and function, particularly with respect to its most prominent target, p53. For example, recent knock-in mouse studies have shown that MDM2 heterooligomer formation with its homolog, MDMX, is necessary and sufficient in utero to suppress p53 but is dispensable during adulthood. However, despite crucial advances such as these, several aspects regarding basic in vivo functions of MDM2 remain unknown. In one such example, although abundant evidence suggests that MDM2 forms homooligomers and heterooligomers with MDMX, the function and regulation of these homo- and heterooligomers in vivo remain incompletely understood. In this review, we discuss the current state of our knowledge of MDM2 oligomerization as well as current efforts to target the MDM2 oligomer as a broad therapeutic option for cancer treatment.
Universal high-momentum asymptote and thermodynamic relations in a spinless Fermi gas with a resonant $p$-wave interaction
Creators: name: Yoshida, Shuhei M.
name: Ueda, Masahito
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We investigate universal relations in a spinless Fermi gas near a $p$-wave Feshbach resonance. We show that the momentum distribution $n_{\vec{k}}$ has an asymptote proportional to $k^{-2}$ with the proportionality constant--the $p$-wave contact-- scaling with the number of closed-channel molecules. We prove the adiabatic sweep theorem for a $p$-wave resonance which reveals the physical meaning of the $p$-wave contact in thermodynamics. In contrast to the unitary Fermi gas in which Tan's contact is universal, the $p$-wave contact depends on the short-range details of the interaction.
Transport and optical properties of an electron gas in a Sierpinski carpet
Creators: name: van Veen, Edo
name: Tomadin, Andrea
name: Katsnelson, Mikhail I.
name: Yuan, Shengjun
name: Polini, Marco
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Recent progress in the design and fabrication of artificial two-dimensional (2D) materials paves the way for the experimental realization of electron systems moving on plane fractals. In this work, we present the results of computer simulations for the conductance and optical absorption spectrum of a 2D electron gas roaming on a Sierpinski carpet, i.e. a plane fractal with Hausdorff dimension intermediate between one and two. We find that the conductance is sensitive to the spatial location of the leads and that it displays fractal fluctuations whose dimension is compatible with the Hausdorff dimension of the sample. Very interestingly, electrons in this fractal display a broadband optical absorption spectrum, which possesses sharp "molecular" peaks at low photon energies.
description: 6 pages, 5 figures; comments are very welcome
Finite elements in some vector lattices of nonlinear operators
Creators: name: Pliev, M. A.
name: Weber, M. R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: Primary 47H07, Secondary 47H99

description: We study the collection of finite elements $Φ_{1}(\mathcal{U}(E,F))$ in the vector lattice $\mathcal{U}(E,F)$ of orthogonally additive, order bounded (called abstract Uryson) operators between two vector lattices $E$ and $F$, where $F$ is Dedekind complete. In particular, for an atomic vector lattice $E$ it is proved that for a finite element in $ϕ\in \mathcal{U}(E,\mathbb{R})$ there is only a finite set of mutually disjoint atoms, where $ϕ$ does not vanish and, for an atomless vector lattice the zero-vector is the only finite element in the band of $σ$-laterally continuous abstract Uryson functionals. We also describe the ideal $Φ_{1}(\mathcal{U}(\mathbb{R}^n,\mathbb{R}^m))$ for $n,m\in\mathbb{N}$ and consider rank one operators to be finite elements in $\mathcal{U}(E,F)$.
Myogenic transcription factors regulate pro-metastatic miR-182
Creators: name: Kirsch,
name: Dodd,
name: Brigman,
name: Eward,
name: Ma,
name: Kim,
name: Dodd,
name: Mito,
name: Sachdeva,
name: Lev,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Approximately thirty percent of patients with soft-tissue sarcoma die from pulmonary metastases. The mechanisms that drive sarcoma metastasis are not well understood. Recently, we identified miR-182 as a driver of sarcoma metastasis in a primary mouse model of soft-tissue sarcoma. We also observed elevated miR-182 in a subset of primary human sarcomas that metastasized to the lungs. Here, we show that myogenic differentiation factors regulate miR-182 levels to contribute to metastasis in mouse models. We find that MyoD directly binds the miR-182 promoter to increase miR-182 expression. Furthermore, mechanistic studies revealed that Pax7 can promote sarcoma metastasis in vivo through MyoD-dependent regulation of pro-metastatic miR-182. Taken together, these results suggest that sarcoma metastasis can be partially controlled through Pax7/MyoD-dependent activation of miR-182 and provide insight into the role that myogenic transcription factors play in sarcoma progression.
On the rate analysis of inexact augmented Lagrangian schemes for convex optimization problems with misspecified constraints
Creators: name: Ahmadi, H.
name: Aybat, N. S.
name: Shanbhag, U. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: We consider a misspecified optimization problem that requires minimizing of a convex function $f(x;θ^*)$ in x over a constraint set represented by $h(x;θ^*)\leq 0$, where $θ^*$ is an unknown (or misspecified) vector of parameters. Suppose $θ^*$ can be learnt by a distinct process that generates a sequence of estimators $θ_k$, each of which is an increasingly accurate approximation of $θ^*$. We develop a first-order augmented Lagrangian scheme for computing an optimal solution $x^*$ while simultaneously learning $θ^*$.
description: For the extended journal version of this preliminary work, see arXiv:1608.01879 [math.OC]
Supplementary document for Free-space creation of a perfect vortex beam with fractional topological charge - 6204327.pdf
Creators: name: Wang, Guanxue
name: weng, xiaoyu
name: Kang, Xiangyu
name: Li, Ziyan
name: Chen, Keyu
name: Gao, Xiumin
name: zhuang, songlin
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: subject: 20501 Classical and Physical Optics
subject: FOS: Physical sciences

description: Supplemental Document
Kogelberg research site KBE/3, site 3418BD/3/7
Creators: name: Jonkershoek Forestry Research Center
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: Jonkershoek Forestry Research Centre
Kogelberg research site
Kogelberg

description: This is a scanned copy of a document on Kogelberg research site KBE/3, site 3418BD/3/7. The Jonkershoek Forestry Research Center (part of the former South African Forestry Research Institute) was established in 1935 at Jonkershoek, near Stellenbosch, under the directorship of Dr C. L. Wicht. The initial aim was to determine how forestry activities in state plantations would affect climate, water conservation and erosion, and was later expanded to include studies of fynbos ecology, fire and alien species. Studies from the 1930s to the early 1990s saw the accumulation of a large amount of data dealing with fire experiments, detailed vegetation plot surveys, rare plant surveys and ecological studies, hydrological studies and the development of management plans for catchments around the Western Cape. SAEON now houses the archive of data collected by the Jonkershoek Forestry Research Center, which was originally held by the Council for Scientific and Industrial Research (CSIR).
The prompt $J/ψ$ production in Association with a $c\bar{c}$ Pair within the Framework of Non-relativistic QCD via photon-photon collision at the International Linear Collider
Creators: name: Sun, Zhan
name: Wu, Xing-Gang
name: Zhang, Hong-Fei
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a systematical study on the prompt $J/ψ$ production in association with a $c\bar{c}$ pair via the process, $γγ\to H(c\bar{c}) +c+\bar{c}$, within the framework of non-relativistic QCD at the future high-energy $e^{+}e^{-}$ collider - International Linear Collider (ILC), including both direct and feed-down contributions. For direct $J/ψ$ production, the states with color-octet channels, especially the $^3P_J^{[8]}$ and $^1S_0^{[8]}$ ones, provide dominant contribution to the production cross-section, which are about fifty-two times over that of the color-singlet one. This is clearly shown by the transverse momentum ($p_t$) and rapidity distributions. The feed-down contribution from $ψ'$ and $χ_{cJ}$ ($J=0,1,2$) is sizable, which is about $20\%$ to the total prompt cross-section. Besides the yields, we also calculate the $J/ψ$ polarization parameter $λ$. In small $p_t$ region, the polarization of the prompt $J/ψ$ is longitudinal due to large contributions through the $^3P_J^{[8]}$ channel, and becomes transverse in high $p_t$ region due to $^3S_1^{[8]}$ channel. Thus the $J/ψ$ production via photon-photon collisions at the ILC shall provide a useful platform for testing the color-octet mechanism.
description: 8 pages, 8 figures. References updated and discussions improved. To be published in Phys.Rev.D
Precision measurement of the mass difference between light nuclei and anti-nuclei
Creators: name: ALICE Collaboration
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The measurement of the mass differences for systems bound by the strong force has reached a very high precision with protons and anti-protons. The extension of such measurement from (anti-)baryons to (anti-)nuclei allows one to probe any difference in the interactions between nucleons and anti-nucleons encoded in the (anti-)nuclei masses. This force is a remnant of the underlying strong interaction among quarks and gluons and can be described by effective theories, but cannot yet be directly derived from quantum chromodynamics. Here we report a measurement of the difference between the ratios of the mass and charge of deuterons and anti-deuterons, and $^{3}{\rm He}$ and $^3\overline{\rm He}$ nuclei carried out with the ALICE (A Large Ion Collider Experiment) detector in Pb-Pb collisions at a centre-of-mass energy per nucleon pair of 2.76 TeV. Our direct measurement of the mass-over-charge differences confirm CPT invariance to an unprecedented precision in the sector of light nuclei. This fundamental symmetry of nature, which exchanges particles with anti-particles, implies that all physics laws are the same under the simultaneous reversal of charge(s) (charge conjugation C), reflection of spatial coordinates (parity transformation P) and time inversion (T).
description: 16 pages, 3 captioned figures, authors from page 11, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/1850
STAT3 selectively interacts with Smad3 to antagonize TGF-β
Creators: name: Yu,
name: Lin,
name: Liu,
name: Feng,
name: Liang,
name: Sun,
name: Wang,
name: Zhan,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Smad and STAT proteins are critical signal transducers and transcription factors in controlling cell growth and tumorigenesis. Here we report that the STAT3 signaling pathway attenuates TGF-β-induced responses through a direct Smad3-STAT3 interplay. Activated STAT3 blunts TGF-β-mediated signaling. Depletion of STAT3 promotes TGF-β-mediated transcriptional and physiological responses, including cell cycle arrest, apoptosis and epithelial-to-mesenchymal transition. STAT3 directly interacts with Smad3 in vivo and in vitro, resulting in attenuation of the Smad3-Smad4 complex formation and suppression of DNA-binding ability of Smad3. The N-terminal region of DNA-binding domain of STAT3 is responsible for the STAT3-Smad3 interaction and also indispensable for STAT3-mediated inhibition of TGF-β signaling. Thus, our finding illustrates a direct crosstalk between the STAT3 and Smad3 signaling pathways that may contribute to tumor development and inflammation.
Absolute continuity of complex Bernoulli convolutions
Creators: name: Shmerkin, Pablo
name: Solomyak, Boris
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: Primary 28A78, 28A80, secondary 37A45, 42A38

description: We prove that complex Bernoulli convolutions are absolutely continuous in the supercritical parameter region, outside of an exceptional set of parameters of zero Hausdorff dimension. Similar results are also obtained in the biased case, and for other parametrized families of self-similar sets and measures in the complex plane, extending earlier results.
description: 22 pages, no figures
CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1
Creators: name: Powell,
name: Woodcock,
name: Ruszkiewicz,
name: Zhu,
name: Moretti,
name: Gliddon,
name: Jarman,
name: Parise,
name: Pitson,
name: Pitman,
name: Tin,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: CIB1 (calcium and integrin binding protein 1) is a small intracellular protein with numerous interacting partners, and hence has been implicated in various cellular functions. Recent studies have revealed emerging roles of CIB1 in regulating cancer cell survival and angiogenesis, although the mechanisms involved have remained largely undefined. In investigating the oncogenic function of CIB1, we initially found that CIB1 is widely up-regulated across a diverse range of cancers, with this up-regulation frequently correlating with oncogenic mutations of KRas. Consistent with this, we found that ectopic expression of oncogenic KRas and HRas in cells resulted in elevated CIB1 expression. We previously described the Ca2+-myristoyl switch function of CIB1, and its ability to facilitate agonist-induced plasma membrane localisation of sphingosine kinase 1 (SK1), a location where SK1 is known to elicit oncogenic signalling. Thus, we examined the role this may play in oncogenesis. Consistent with these findings, we demonstrated here that over-expression of CIB1 by itself is sufficient to drive localisation of SK1 to the plasma membrane and enhance the membrane associated enzymatic activity of SK1, as well as its oncogenic signalling. We subsequently demonstrated that elevated levels of CIB1 resulted in full neoplastic transformation, in a manner dependent on SK1. In agreement with our previous findings that SK1 is a downstream mediator of oncogenic signalling by Ras, we found that targeting CIB1 also inhibited neoplastic growth of cells induced by oncogenic Ras, suggesting an important pro-tumorigenic role for CIB1. Thus, we have demonstrated for the first time a role for CIB1 in neoplastic transformation, and revealed a novel mechanism facilitating oncogenic signalling by Ras and SK1.