cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Gradient estimates for problems with Orlicz growth
Creators: name: Chlebicka, Iwona
Publisher: name: arXiv
Year: 2018
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We study a general nonlinear elliptic equation in the Orlicz setting with data not belonging to the dual of the energy space. We provide several Lorentz-type and Morrey-type estimates for the gradients of solutions under various conditions on the data.
Pterapotrechus Karny 1937
Creators: name: Hegg, Danilo
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Gryllacrididae
Pterapotrechus

description: GenusPterapotrechusKarny, 1937
Pterapotrechus Karny, 1937: 73.
Pterapotrechus — Green and Ramsay 2003: 75–77. — Cadena-Castañeda 2019: 99.
Diagnosis. —
(After Karny 1937) The main feature differentiating Pterapotrechus from most other Australian genera of Gryllacrididae is the prominent angular ridge running from the insertion of the antennae to the base of the mandibles and delimiting the frons on the sides. While this feature is shared with the genus Apotrechus Brunner von Wattenwyl, 1888, the latter genus is wingless. In Pterapotrechus, fore- and hindwings are well developed in adults of both sexes.
Habitat and ecology. —
Pterapotrechus are nocturnal, predatory rainforest insects.
Distribution. —
Native to coastal Northern Territory and Queensland, Australia, and extending into northern New South Wales. Introduced in North Island, New Zealand.
Etymology. —
From the Ancient Greek πτερόν (pterón), ‘ wing’, (Karny 1937) and ὰποτρέχω (apotrechus), ‘ avoidant, running away’ (Brunner von Wattenwyl 1888). A winged version of the wingless genus Apotrechus Brunner von Wattenwyl, 1888. Pterapotrechus is male gender.
Type species. —
Paragryllacris beta Griffini, 1909.
description: Published as part of Hegg, Danilo, 2025, An Australian raspy cricket established in New Zealand, Pterapotrechus salomonoides (Orthoptera, Gryllacrididae), with notes on ecology and first description of the male, pp. 77-94 in Journal of Orthoptera Research 34 (1) on pages 77-94, DOI: 10.3897/jor.34.134391
On the Ubiquity of K3 Fibrations in String Duality
Creators: name: Aspinwall, Paul S.
name: Louis, Jan
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider the general case of N=2 dual pairs of type IIA/heterotic string theories in four dimensions. We show that if the type IIA string in this pair can be viewed as having been compactified on a Calabi-Yau manifold in the usual way then this manifold must be of the form of a K3 fibration. We also see how the bound on the rank of the gauge group of the perturbative heterotic string has a natural interpretation on the type IIA side.
description: LateX, 16 pages, 1 figure, minor corrections, reference added
Additional file 1 of A unified global genotyping framework of dengue virus serotype-1 for a stratified coordinated surveillance strategy of dengue epidemics
Creators: name: Li, Liqiang
name: Guo, Xiang
name: Zhang, Xiaoqing
name: Zhao, Lingzhai
name: Li, Li
name: Wang, Yuji
name: Xie, Tian
name: Yin, Qingqing
name: Jing, Qinlong
name: Hu, Tian
name: Li, Ziyao
name: Wu, Rangke
name: Zhao, Wei
name: Xin, Sherman Xuegang
name: Shi, Benyun
name: Liu, Jiming
name: Xia, Shang
name: Peng, Zhiqiang
name: Yang, Zhicong
name: Zhang, Fuchun
name: Chen, Xiao-Guang
name: Zhou, Xiaohong
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Supplementary Figures and tables for this study.
Reconstruction of neutrino induced neutral current neutral pion events with the T2K ND280 Tracker and ECAL
Creators: name: Guzowski, Pawel
Publisher: name: Imperial College London
Year: 2011

description: T2K is a long baseline neutrino oscillation experiment in Japan. One of the goals is to search for electron neutrino appearance at the far detector (Super Kamiokande) in a muon neutrino beam produced 295 km away, to make a measurement of the unknown neutrino oscillation angle [Symbol appears here. To view, please open pdf attachment]13. A major background to this appearance search is neutral pions (π0) produced in neutral current (NC) neutrino interactions. The π0s decay to photons, which can in cases mimic the electron appearance signal. The near detector of the experiment (ND280) has the capability of measuring the rates of NCπ0 production processes. NCπ0 interactions in the Tracker of the detector (plastic scintillator targets, and time projection chambers for tracking charged particles) can be detected through photon conversions in the electromagnetic calorimeter that surrounds the Tracker. For these types of events, the photon reconstruction in the calorimeter has to have good energy and angular resolutions. This thesis describes the T2K experiment, the ND280 detector and its offline software, and gives details on the ECal reconstruction of photons. The performance of the reconstruction in relation to the π0 decay photons, their energy and angular resolutions, is studied. An analysis is presented for the reconstruction of NC π0s produced in the trackers, with both photons converting in the downstream calorimeter, developed purely with Monte Carlo (with GENIE as the interaction generator), and then applied to the first-year data from ND280. The Monte Carlo expectation is 17.7 ± 1.1(stat) ± 4.9(syst) events, with 37 ± 4% NCπ0 purity; 21 events are seen in the first year data. The MC is consistent with data at the 0.5σ level. As a crosscheck, the same analysis is applied to a different Monte Carlo production (using NEUT as the generator). The expectation from this production is 16.8 ± 1.0(stat) ± 4.7(syst) events, with 30 ± 4% purity. This is consistent with data at the 0.7σ level.
Stratigraphic Phases of the Ramp of Thutmose III, Maquette AS-2021-L-2
Creators: name: Colin, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Archaeological excavations
subject: Egypt
subject: Egypt, Ancient
subject: Egypt--Antiquities
subject: Egyptology

description: The repository includes the maquette in spp-file (Adobe Substance Painter) and a screenshot in png.

How to quote this model in a scientific paper?

Fr. Colin, “Stratigraphic phases of the ramp of Thutmose III”, Maquette AS-2021-L-2, Strasbourg, 2023, DOI: 10.34847/nkl.6712w17k, https://skfb.ly/oFEop.

Note that specifying the model DOI is necessary to ensure its permanent quotation, regardless of its location. It is stored in a long-lasting way on the data service “Nakala” of the “TGIR Huma-Num” (https://www.nakala.fr).

The “maquette” Stratigraphic Context of Thutmose III’s Mudbricks, AS-2021-L-2, has been conducted to document the artifacts and contexts uncovered by the French Archaeological Mission in Asasif (Luxor, Egypt) and to prepare the publication.

Photographic survey, photogrammetric processing & modeling: Fr. Colin. Topography: Cassandre Hartenstein. Univ. de Strasbourg, CNRS, UMR 7044 Archimède.

Partners of the project: Egyptian Ministry of Tourism and Antiquities, IFAO, Univ. de Strasbourg, CNRS.

Légende 1 : phase 1, construction de la rampe. Légende 2 : phase 2, fonctionnement de la chaussée. Légende 3 : phase 4a, creusement par Padiamenopé d’un talus à travers la rampe en direction de la première cour de la TT 33. Légende 4 : phase 4b, déblais de creusement à travers la rampe par Padiamenopé. Légende 5 : phase 4c, déblais de creusement par Padiamenopé à travers la formation Calcaire de Tarawan.
Njáll im Hörbuch
Creators: name: Hahn, Daniela
Publisher: name: Humboldt-Universität zu Berlin
Year: 2020
Subjects: subject: Hörbuch
subject: Njáll
subject: Mediävistik
subject: Medien
subject: Island
subject: Saga
subject: Skandinavistik
subject: 839 Andere germanische Literaturen

description: Dieser Beitrag vergleicht zwei 2011 (wieder-)erschienene Audiobearbeitungen der altisländischen Brennu-Njáls saga. Dabei wird zunächst ein Überblick über die verschiedenen Neubearbeitungen altnordischer Stoffe auf dem deutschen Hörbuchmarkt gegeben sowie ein kurzer Einblick in das Feld der Hörbuchforschung. Anschließend wird gefragt, mit welchen Mitteln sich die beiden sehr unterschiedlichen Bearbeitungen ihrem mittelalterlichen Vorbild nähern. Während die erste Bearbeitung ein streng arrangiertes Hörspiel mit neuem Leitmotiv darstellt, handelt es sich bei der zweiten Audiobearbeitung um eine freie Nacherzählung. Insbesondere in der Plotstruktur und der Figurenzeichnung setzen die beiden Hörformate neue Schwerpunkte, die hier untersucht werden.
description: This article compares two audiobooks, (re)published in 2011, based on the Old Norse Brennu-Njáls saga. An overview of the various audio editions of Old Norse material in the German audiobook market will be given, along with a brief insight into the field of audiobook research. Afterwards, the inquiry will turn to the means by which the two very different audiobooks approach the medieval saga. While the first project is a strictly arranged drama including a new leitmotif, the second audio edition is a free retelling. Especially in terms of plot structure and character depiction, the two audio formats set new priorities, which are examined here.
Bayesian optimization of the PC algorithm for learning Gaussian Bayesian networks
Creators: name: Córdoba, Irene
name: Garrido-Merchán, Eduardo C.
name: Hernández-Lobato, Daniel
name: Bielza, Concha
name: Larrañaga, Pedro
Publisher: name: arXiv
Year: 2018
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: The PC algorithm is a popular method for learning the structure of Gaussian Bayesian networks. It carries out statistical tests to determine absent edges in the network. It is hence governed by two parameters: (i) The type of test, and (ii) its significance level. These parameters are usually set to values recommended by an expert. Nevertheless, such an approach can suffer from human bias, leading to suboptimal reconstruction results. In this paper we consider a more principled approach for choosing these parameters in an automatic way. For this we optimize a reconstruction score evaluated on a set of different Gaussian Bayesian networks. This objective is expensive to evaluate and lacks a closed-form expression, which means that Bayesian optimization (BO) is a natural choice. BO methods use a model to guide the search and are hence able to exploit smoothness properties of the objective surface. We show that the parameters found by a BO method outperform those found by a random search strategy and the expert recommendation. Importantly, we have found that an often overlooked statistical test provides the best over-all reconstruction results.
Old high-redshift galaxies and primordial density fluctuation spectra
Creators: name: Peacock, J. A.
name: Jimenez, R.
name: Dunlop, J. S.
name: Waddington, I.
name: Spinrad, H.
name: Stern, D.
name: Dey, A.
name: Windhorst, R. A.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We have discovered a population of extremely red galaxies at $z\simeq 1.5$ which have apparent stellar ages of $\gs 3$ Gyr, based on detailed spectroscopy in the rest-frame ultraviolet. In order for galaxies to have existed at the high collapse redshifts indicated by these ages, there must be a minimum level of power in the density fluctuation spectrum on galaxy scales. This paper compares the required power with that inferred from other high-redshift populations. If the collapse redshifts for the old red galaxies are in the range $z_c\simeq 6$ -- 8, there is general agreement between the various tracers on the required inhomogeneity on 1-Mpc scales. This level of small-scale power requires the Lyman-limit galaxies to be approximately $ν\simeq 3.0$ fluctuations, implying a very large bias parameter $b\simeq 6$. The high collapse redshifts of the red galaxies as deduced from gravitational collapse provides independent support for the ages estimated from their stellar populations. Such early-forming galaxies are rare, and their contribution to the cosmological stellar density is consistent with an extrapolation to higher redshifts of the star-formation rate measured at $z<5$; there is no evidence for a general era of spheroid formation at extreme redshifts.
description: 9 Pages MNRAS in press. Uses MNRAS Plain TeX macros
Quantization of the Relativistic Particle
Creators: name: Gavrilov, S. P.
name: Gitman, D. M.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We revise the problem of the quantization of relativistic particle, presenting a modified consistent canonical scheme, which allows one not only to include arbitrary backgrounds in the consideration but to get in course of the quantization a consistent relativistic quantum mechanics, which reproduces literally the behavior of the one-particle sector of the corresponding quantum field. At the same time this construction presents a possible solution of the well-known old problem how to construct a consistent quantum mechanics on the base of a relativistic wave equation.
description: 10 pages
Effects of cerium oxide nanoparticles on biochemical and oxidative parameters in marigold leaves
Creators: name: Jahani, Sedighe
name: Saadatmand, Sara
name: Mahmoodzadeh, Homa
name: Khavari-Nejad, Ramazan Ali
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology
subject: 60506 Virology

description: The effects of suspensions of cerium oxide nanoparticles sprayed onto marigold seedlings (Calendula officinalis L.) at concentrations between 50 and 3200 mg L−1 were studied. At concentrations of 50 and 100 mg L−1, the nanoparticles had a slight positive effect on some growth parameters, but at higher concentrations they caused severe oxidative damage. Activities of phenylalanine ammonia lyase and lipoxygenase increased from 400 mg L−1 upward, tyrosine ammonia lyase from 1600 mg L−1. Ascorbate and glutathione contents decreased from 400 mg L−1 upwards.
Oral history interview with Leighton McLendon 1975
Publisher: name: Columbia University
Year: 2019
Subjects: Electricians
Labor unions
Factory management
Manufacturing processes
Consolidation and merger of corporations

description: Training as electrician and welder; Gair plant construction work, Savannah; duties as pulp mill and paper mill electrician; attitude towards union-management negotiations; history of electricians union; safety concerns, equipment, troubleshooting; summer youth employment program, bull gang work; changes in race relations in the South; Gair merger with Continental Can; industrial relations department; loss of fraternity in plant.
Ancillary service needs among persons new to HIV care and the relationship between needs and late presentation to care
Creators: name: Lesko, C.R
name: Chander, G
name: Napravnik, S
name: Mugavero, M.J
name: Monroe, A.K
name: Keruly, J
name: Amico, K.R
name: Crane, H.M
name: Quinlivan, E.B
name: Lau, B
Publisher: name: Routledge
Year: 2019

description: Ancillary service needs likely influence time to diagnosis and presentation for HIV care. The effect of both met and unmet needs on late presentation to HIV care is not well understood. We used baseline data from 348 people with HIV (PWH) with no prior HIV care who enrolled in iENGAGE (a randomized controlled trial (RCT) of an intervention to support retention in care) at one of four HIV clinics in the US. A standardized baseline questionnaire collected information on ancillary service needs, and whether each need was presently unmet. We examined covariates known to be associated with disease stage at presentation to care and their association with needs. We subsequently assessed the relationship of needs with CD4 accounting for those other covariates by estimating prevalence ratios (PR) using inverse probability weights. Most patients enrolling in the RCT were male (79%) and the majority were Black (62%); median age was 34 years. Prevalence of any reported individual need was 69%. One-third of the sample had a baseline CD4 cell count <200, 42% between 200 and 499 and 27% ≥500. There was no statistically significant association between need or unmet need and baseline CD4. In general, psychiatric health and SU issues (depression, anxiety, and drug use) were consistently associated with higher prevalence of need (met and unmet). Additionally, the Black race was associated with higher basic resource needs (housing: PR 1.67, 95%CI 1.08–2.59; transportation: PR 1.65, 95% CI 1.12–2.45). Ancillary service needs (met and unmet) were common among patients new to HIV care and impacted vulnerable subgroups. However, we found no evidence that reporting a specific individual need, whether met or unmet, was associated with a timely presentation to HIV care. The impact of needs on subsequent steps of the HIV care continuum will be examined with longitudinal data.
Optoelectronic properties of zinc oxide: A first-principles investigation using the Tran-Blaha modified Becke-Johnson potentia
Creators: name: Almeida, R. M. V. S.
name: da Rosa, A. L.
name: de Almeida, J. S.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In this work we use density functional theory (DFT) to investigate the influence of semi-local exchange and correlation effects on the electronic and optical properties of zinc oxide. We find that the inclusion of such effects using the Tran-Blaha modified Becke-Johnson potential yields an excellent description of the electronic structure of this material giving energy band gap which is systematically larger than the one obtained with standard local functionals such as the generalized gradient approximation. The discrepancy between the experimental and theoretical band gaps is then significantly reduced at a computational low cost. We also calculated the dielectric functions of ZnO and find a violet shift to the absorption edge which is in good agreement with experimental results.
description: 12 pages, 2 figures
Conserved currents for unconventional supersymmetric couplings of self-dual gauge fields
Creators: name: Devchand, Ch.
name: Ogievetsky, V.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Self-dual gauge potentials admit supersymmetric couplings to higher-spin fields satisfying interacting forms of the first order Dirac--Fierz equation. The interactions are governed by conserved currents determined by supersymmetry. These super-self-dual Yang-Mills systems provide on-shell supermultiplets of arbitrarily extended super-Poincaré algebras; classical consistency not setting any limit on the extension N. We explicitly display equations of motion up to the $N=6$ extension. The stress tensor, which vanishes for the $N\le 3$ self-duality equations, not only gets resurrected when $N=4$, but is then a member of a conserved multiplet of gauge-invariant tensors.
description: 6 pages, latex file
Characterisation of bone marrow progenitor cells in disease
Creators: name: Gowers, Kate Hayley Christine
Publisher: name: Imperial College London
Year: 2012

description: The bone marrow serves as a reservoir for leukocytes and stem cells, from where cells can be mobilised into the circulation and can be recruited to sites of inflammation. Mobilisation of cells out of the bone marrow is dependent on their migration across the bone marrow sinusoidal endothelium, which is thought to be structurally and functionally different to endothelial cells from other vascular beds. In order to characterise the bone marrow endothelium and to study the molecular mechanisms involved in the mobilisation of cells, a protocol to isolate bone marrow endothelial cells and to grow them in vitro was developed. The bone marrow contains a number of distinct progenitor cell populations, including endothelial progenitor cells (EPCs) and mesenchymal stem cells (MSCs). Whether these populations of stem cells are recruited from the bone marrow to the lungs was investigated in two contrasting models of lung disease: the house dust mite (HDM) model of allergic airways disease and the bleomycin model of pulmonary fibrosis. In the HDM model increased recruitment of EPCs to the inflamed lungs was associated with increased peribronchial angiogenesis, and reduced EPC numbers in the bone marrow. Blocking VEGF inhibited EPC recruitment to the inflamed lungs and reduced the associated peribronchial angiogenesis. In this model, no recruitment of MSCs to the inflamed lungs was observed. However, in the bleomycin model, a significant elevation in MSC numbers was observed in the circulation, lung tissue and BAL fluid. Experiments to block the recruitment of MSCs to the lungs in response to bleomycin injury were performed, along with investigations into the recruitment of exogenously administered MSCs to the injured lungs. A population of MSCs residing in the naïve lungs was identified, which are phenotypically similar to bone marrow MSCs, but can be distinguished by their size and expression of specific cell surface antigens.
title: ADCO, Cartulaire de l'abbaye de Saint-Seine (XIIIe siècle), Cart. 165 (10 H 6, ms. 139), 354 pages, f. 0290
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2009
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: cartulaire
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire de l'abbaye de Saint-Seine (XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 165 (10 H 6, ms. 139), 354 pages, f. 0290, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'abbaye de Saint-Seine (XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 165 (10 H 6, ms. 139), 354 pages, f. 0290, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Saint-Seine
description: Provenance: http://www.wikidata.org/entity/Q2820709
Recent advances in the computational chemistry of soft porous crystals
Creators: name: Fraux, Guillaume
name: Coudert, François-Xavier
Publisher: name: arXiv
Year: 2018
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Here we highlight recent progress in the field of computational chemistry of nanoporous materials, focusing on methods and studies that address the extraordinary dynamic nature of these systems: the high flexibility of their frameworks, the large-scale structural changes upon external physical or chemical stimulation, and the presence of defects and disorder. The wide variety of behavior demonstrated in soft porous crystals, including the topical class of metal-organic frameworks, opens new challenges for computational chemistry methods at all scales.
Leg length, a marker of early childhood conditions, associates with specific clusters of serum fatty acids
Creators: name: Johnston, Luke
name: Liu, Zhen
name: Retnakaran, Ravi
name: Harris, Stewart B.
name: Bazinet, Richard P.
name: Hanley, Anthony J.
Publisher: name: figshare
Year: 2018
Subjects: subject: Diseases
subject: Pathogenesis
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Poster presentation at the European Association for the Study of Diabetes in Berlin, Germany from Oct 1-5, 2018.
Dissecting the Function of Histone Deacetylases: A Three-Pronged Approach from Probes to Protein-Engineering
Creators: name: Felstead, Robert
Publisher: name: Imperial College London
Year: 2012

description: Histone deacetylases (HDACS) are a class of enzymes responsible for deacetylating the lysine residues of histones in chromatin. Inhibitors of these enzymes have shown promise in the treatment of a number of diseases including neurodegenerative diseases such as Alzheimer’s and Huntingdon’s disease, various cancers and most recently as a treatment for acute myocardial infarction. There are 11 zinc-dependent isoforms of HDACs present in humans but to date the majority of inhibitors of these enzymes have shown broad inhibition across all isoforms. This makes determination of the function of individual isoforms via chemical means very difficult. This thesis outlines three chemical methods; namely protein-ligand engineering, isoform-selective inhibitor discovery and activity based protein profiling that have been developed towards dissecting the function of individual histone deacetylase isoforms. A histone deacetylase 1 (HDAC1) mutant protein-ligand pair was designed with the aid of a computational docking program and site-directed mutagenesis used to introduce the mutation into HDAC1, which was expressed in Sf9 cells. A set of potentially selective inhibitors was then synthesised and tested for selectivity compared to the wild-type histone deacetylase 1. A novel series of potential isoform-selective inhibitors were designed based around a cyclotetrapeptide capping group and a 2-phenylamide zinc-binding group and joined together via a ruthenium catalysed cross-metathesis reaction. These were then tested for selectivity against HDAC1 and HDAC2 in a fluorimetric assay. Finally, an activity-based protein profiling probe specific to HDACs was designed and synthesised. The probe was designed to have a reactive chloromethyl ketone head group that would irreversibly bind to HDACs as well as an alkyne group to allow attachment of a fluorescent tag via the copper mediated alkyne-azide ‘click’ reaction. The probe was then tested for its ability to label HDACs in vitro and an in vivo system expressing HDAC1.
Light Monopoles, Electric Vortices and Instantons
Creators: name: Guilarte, Juan Mateos
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The physics of the bare Seiberg-Witten action, without supersymmetric partners, is considered in the framework of standard Quantum Field Theory. The topological analysis related to the solutions of the Seiberg-Witten equations is performed and the phase structure of the model is analysed.
description: 9 pages, latex
Alcohol Use Patterns and Subsequent Sexual Behaviors Among Women, Men who have Sex with Men and Men who have Sex with Women Engaged in Routine HIV Care in the United States
Creators: name: Mayer, K.H
name: Cropsey, K.L
name: Lau, B
name: Christopoulos, K
name: Fredericksen, R.J
name: Thompson, C.B
name: Chander, G
name: Hutton, H.E
name: Crane, H.M
name: Li, X
name: McCaul, M.E
name: Lesko, C.R
name: Mathews, W.C
name: Napravnik, S
name: Saag, M
Publisher: name: Springer New York LLC
Year: 2019

description: Among people with HIV, alcohol use is associated with increased prevalence of sexual transmission behaviors. We examined associations between alcohol use in the prior year and sexual behaviors approximately six months later among 1857 women, 6752 men who have sex with men (MSM) and 2685 men who have sex with women (MSW). Any alcohol use was associated with increased risk of unsafe vaginal sex among women; anal sex and =>2 anal sex partners among MSM; and anal sex, =>2 anal or vaginal sex partners, and unsafe vaginal sex among MSW. In particular, among women >7 alcoholic drinks/week and among MSW =>5 alcoholic drinks/drinking day increased the likelihood of certain subsequent sexual behaviors. For all groups, especially women, the risk of sex under the influence of drugs/alcohol markedly increased with increases in quantity and frequency of alcohol consumption. These different patterns of drinking and sexual behaviors indicate the importance of tailored counseling messages to women, MSM and MSW.
The edge-on spiral gravitational lens B1600+434
Creators: name: Koopmans, L. V. E.
name: de Bruyn, A. G.
name: Jackson, N.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present new observations of the gravitational lens (GL) system B1600+434, strongly suggesting that the lens is an edge-on spiral galaxy. These observations are used to constrain the mass model of the system, in particular the oblateness and velocity dispersion of the dark matter halo around the lensing galaxy. From an analytical model we find a lower limit on the halo oblateness $q_\rmn{halo}=(c/a)_ρ\ga0.4$; more detailed numerical models give a lower limit $q_\rmn{h}\ga0.5$. We determine an average halo velocity dispersion of $σ_{halo}=190\pm 15$ km/s over all non-singular isothermal elliptical (NIE) halo models. Constraining the models to larger and more massive disks, decreases this average by only 10 km/s. A lower limit of $σ_{halo}\ga 150$ km/s is found, even for disk masses larger then the mass inside the Einstein radius. This lower limit indicates the need for a massive dark matter halo, contributing at least half of the mass inside the Einstein radius. Time delay calculations give $(54\pm3)/h_{50}$ days for the NIE halo model and $(70\pm4)/h_{50}$ days for the modified Hubble profile (MHP) halo model. Although the time delay for both NIE and MHP halo models is well constrained on our parameter grid, it strongly depends on the halo surface density profile. We furthermore find that the presence of a flat luminous mass distribution can severely alter the statistical properties of the lens.
description: 35 pages including 10 PS-figures, and 4 tables. Accepted for publication by MNRAS
Geometric and magnetic properties of coronal flux ropes associated with CMEs leading to geomagnetic storms
Creators: name: Sarkar, Ranadeep
name: Srivastava, Nandita
Publisher: name: arXiv
Year: 2018
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We have studied three Interplanetary Coronal Mass Ejections (ICMEs) having clear signatures of magnetic cloud (MC) arrival at 1 AU and their associated solar sources during 2011 to 2013. Comparing the axial magnetic field strength (B0) of the near-Sun coronal flux-ropes with that of the MC at 1 AU, we have found that the average inferred value of B0 at 1 AU assuming the self-similar expansion of the flux-rope is two times smaller than the value of B0 obtained from the results of MC fitting. Furthermore, by comparing the initial orientation of the flux-rope near the Sun and its final orientation at 1 AU we have found that the three CMEs exhibited more than 80-degree rotation during its propagation through the interplanetary medium. Our study suggests that although the near-Sun magnetic properties of coronal flux-ropes can be used to infer the field strength of the associated MC at 1 AU, it is difficult to estimate the final orientation of the MC axis in order to predict the geo-effectiveness of the ICMEs.
description: 2 Pages, 1 Figure, Accepted for publication in IAU 340 proceeding series, Cambridge university press (CUP)
Histology of Sculpin spp. in East Greenland. II. Histopathology and trace element concentrations
Creators: name: Kaarsholm, Henrik M.
name: Verland, Ninna
name: Nørregaard, Rasmus D.
name: Bach, Lis
name: Søndergaard, Jens
name: Rigét, Frank F.
name: Dietz, Rune
name: Hansen, Martin
name: Eulaers, Igor
name: Desforges, Jean-Pierre
name: Leifsson, Pall S.
name: Dang, Mai
name: Nowak, Barbara
name: Sonne, Christian
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: For many years, the sculpin has been utilized as a sentinel monitoring species for anthropogenic impacts on the marine environment. To further develop its potential as a screening model body burden of several trace elements, including cadmium (Cd), copper (Cu), mercury (Hg), lead (Pb) and selenium (Se), were investigated. In addition, histopathology in shorthorn sculpins (Myoxocephalus scorpius; n = 20) and fourhorn sculpins (Myoxocephalus quadricornis; n = 10) were examined at three sites around the Scoresby Sound settlement in Central East Greenland. Fourhorn sculpins caught at the most distant site from the settlement, contained significantly higher hepatic Cu and Cd concentrations as well as significantly elevated gill Pb levels compared to the shorthorn sculpins collected at two other sites closer to the settlement. Histological examinations showed that fish with significantly higher concentrations of hepatic Cd and Se exhibited greater nuclear alterations, interstitial hyperplasia/hypertrophy, interstitial mononuclear infiltrations and granulomas. Further, fish with higher Cd and Cu gill tissue levels displayed a significantly higher number of cytoplasmic alterations and lamellar epithelium lifting, hypertrophic and hyperplastic epithelium along with mucus cell hyperplasia. While the presence of liver lesions were not species or sex-specific, the presence of gill lesions decreased in the order female fourhorn sculpins > female shorthorn sculpins > male fourhorn sculpins > male shorthorn sculpins. Hepatic Hg concentrations exceeded known lowest observable effect doses (LOED) for fish (0.1–0.5 μg g−1 ww) in 27% of fish, while liver Cd residues in 80% exceeded LOED (0.42–1.8 μg g−1 ww). Based upon these results, data suggest that using the sculpin as a valuable sentinel fish species histopathology may serve as a reliable tool for assessing marine ecosystem exposure to trace metals. However, confounding physiological and ecological factors also need to be considered.
The role of endothelial cell function in regulating fibrinolysis and the development and progression of thromboembolic pulmonary hypertension
Creators: name: Mangles, Sarah
Publisher: name: Imperial College London
Year: 2013

description: Pulmonary hypertension (PH) is a rare but disabling disorder, characterised by raised pulmonary artery pressure leading to right ventricular heart failure, progressive disability and death. Chronic thromboembolic pulmonary hypertension (CTEPH), a distinct category of PH, is a condition in which the initiating event is either overt or occult pulmonary embolism (PE). It is believed that the persistence of thrombus is a prerequisite for the development of PH following PE. It was hypothesised that defective fibrinolysis on the surface of the pulmonary endothelium causes progression from PE to CTEPH. Thrombin generation and fibrinolysis were assayed in parallel on endothelial cells using exogenous tissue factor or TNF-α stimulation. Thrombin generation was measured using a modified calibrated automated thrombogram assay (CAT). Fibrinolysis was measured using a turbidometric assay. Assays were established first on human umbilical vein endothelial cells (HUVECs). The study of patient’s endothelium is complicated by the difficulty in accessing tissue. Using a recently developed technique, blood outgrowth endothelial cells (BOECs) were isolated from the mononuclear fraction of peripheral blood from patients with CTEPH and controls. Discrete colonies of BOECs appeared between days 7-21 in culture. Cells were passaged to obtain confluent BOEC monolayers with characteristic endothelial cobblestone morphology. Endothelial identity was confirmed using immunofluorescence with a range of endothelial markers including VWF and VE-Cadherin. BOECs were successfully isolated from patients with CTEPH and healthy controls in order to evaluate thrombin generation and fibrinolysis using the assays developed on HUVECs. No difference in thrombin generation was observed but surprisingly shorter clot lysis times were shown on BOECs from CTEPH patients as compared to controls. In order to determine the cause of the paradoxical increase in fibrinolysis, mRNA expression of a panel of candidate genes was performed using RT-PCR array analysis. Differences in gene expression were seen between CTEPH and healthy control BOECs. Statistically significant results included an increase in fibroblast growth factor 2 and fibronectin expression with a decrease in VEGF receptor 2 expression. Other genes implicated in the pathogenesis of PH and CTEPH for example endothelin receptor A, matrix metalloproteinase 2 and 9 also showed altered expression and therefore further studies with larger numbers are required to confirm these findings.
Brief report: The association of chronic pain and long-term opioid therapy with HIV treatment outcomes
Creators: name: Long, D
name: Saag, M.S
name: Merlin, J.S
name: Cachay, E.R
name: Kertesz, S.G
name: Crane, H.M
name: Mathews, W.C
name: Starrels, J.L
name: O'Cleirigh, C.C
name: Napravnik, S
name: Edelman, E.J
name: Liebschutz, J.M
name: Claborn, K
name: Becker, W.C
name: Mugavero, M.J
name: Christopoulos, K.A
name: Harding, R
name: Gross, R
Publisher: name: Lippincott Williams and Wilkins
Year: 2018

description: Background: Chronic pain occurs in up to 85% of persons living with HIV and is commonly treated with long-term opioid therapy (LTOT). We investigated the impact of chronic pain and LTOT on HIV outcomes. Methods: This was prospective cohort study conducted between July 2015 and July 2016 in 5 HIV primary care clinics. Chronic pain was defined as ≥moderate pain for ≥3 months on the Brief Chronic Pain Questionnaire. Chronic pain and LTOT were assessed at an index visit. Suboptimal retention, defined as at least one "no-show" to primary care, and virologic failure were measured over the subsequent year. Multivariable logistic regression models were built for each outcome adjusting for site. Results: Among 2334 participants, 25% had chronic pain, 27% had suboptimal retention, 12% had virologic failure, and 19% were prescribed LTOT. Among individuals not on LTOT, chronic pain was associated with increased odds of suboptimal retention [adjusted odds ratio (aOR) 1.46, 95% confidence interval (CI): 1.10 to 1.93, P = 0.009] and virologic failure (aOR 1.97, 95% CI: 1.39 to 2.80, P < 0.001). Among individuals with chronic pain, there was no association between LTOT and retention, but LTOT was associated with lower rates of virologic failure (aOR 0.56, 95% CI: 0.33 to 0.96, P = 0.03). Conclusions: Chronic pain in participants not on LTOT was associated with virologic failure. This reinforces the need to identify effective chronic pain treatments for persons living with HIV and investigate their impact on HIV outcomes. The apparent protective association between LTOT and virologic failure in those with pain merits further exploration.
Development of a high temporal resolution spiral 3D phase velocity mapping technique for analysis of regional myocardial mechanics
Creators: name: Simpson, Robin Matthew
Publisher: name: Imperial College London
Year: 2013

description: MRI is a powerful tool for imaging the heart, allowing the collection of anatomical and functional information non-invasively. Heart function is routinely assessed by global performance via ventricular masses and ejection fraction. Regional dysfunction, often a precursor of disease, can be hidden by apparently healthy global ventricular function and so there is a clear need for accurate and reproducible methods for measuring regional myocardial mechanics. Tissue phase velocity mapping is the only MR technique which is capable of measuring motion over the entire cardiac cycle. Unfortunately current sequences are inefficient and do not fully exploit its full potential. This thesis presents the development of a new high temporal resolution sequence which uses spiral k-space trajectories to speed up the acquisitions, and implements retrospective cardiac gating to extend the technique over the entire heartbeat. Two sequence variations are developed and assessed. The first uses a modified respiratory navigator algorithm to acquire high resolution data in ten healthy volunteers on two occasions, demonstrating very good reproducibility. Measurements in atrial systole have been made for the first time, providing information that previously was only seen from echocardiography. The second sequence variation uses a non-Cartesian SENSE reconstruction to allow the acquisition of similar resolution images within a short breath-hold. This sequence performs as well as the navigator gated sequence despite being acquired in just thirteen heartbeats. Analysis tools have also been developed and colour plots have been used for the first time to present a large amount of data in an easily interpretable way. By speeding up the acquisition of tissue phase velocity mapping data and by extending it over the entire cardiac cycle, the work presented in this thesis provides the potential to routinely acquire information about regional myocardial mechanics in clinical practice.
Local Anomaly Cancellation, M-Theory Orbifolds and Phase-Transitions
Creators: name: Faux, Michael
name: Lust, Dieter
name: Ovrut, Burt A.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper we consider orbifold compactifications of M-theory on $S^1/{\bf Z}_2\times T^4/{\bf Z}_2$. We discuss solutions of the local anomaly matching conditions by twisted vector, tensor and hypermultiplets confined on the local orbifold six-planes. In addition we consider phase-transitions among different solutions which are mediated by M-theory fivebranes which touch the local orbifold planes and are converted there to gauge instantons.
description: 30 pages, 9 figures, revised version corrects an error concerning an hypermultiplet representation
Significance of the Spinorial Basis in the Quantum Theory
Creators: name: Dvoeglazov, Valeri V.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Problems connected with a choice of the spinorial basis in the $(j,0)\oplus (0,j)$ representation space are discussed. As shown it has profound significance in the relativistic quantum theory. From the methodological viewpoint this fact is related with the important dynamical role played by space-time symmetries for all kind of interactions.
description: LaTeX file (sprocl.sty), additional mydef.sty is attached in the end. 4pp. Reported at the IV Wigner Symposium
Investigation of Sinonasal Airflow and Transport
Creators: name: Rennie, Catherine
Publisher: name: Imperial College London
Year: 2013

description: This work comprises an investigation of airflow and transport in the human upper airways, which not only perform essential air conditioning physiological functions (heat and water exchange and primary filtration) but also house the olfactory receptors. The conflicting requirements posed by efficient air transit on the one hand and sampling for olfaction on the other renders the geometry of the upper airways complex. Knowledge of the geometry and flow conditions are primary requirements for understanding the physiological mechanics of the airways. This work describes the application of imaging and experimental measurement techniques to determine the variations in nasal airway geometry and the characteristics of nasal inspiratory flow. Whilst the results are relevant to a host of applications, the particular case of sinonasal ventilation well illustrates the interrelation between form, flow and function as well as motivating the development of improved techniques for clinical management. Specifically 3T MR imaging has been investigated as a means to define the anatomy in congested and decongested states. Results show very large changes in nasal airway calibre and moreover allow the variation in mucosal engorgement throughout the nasal cavity to be mapped. Highly time resolved hot wire measurements of inspiratory flow profiles revealed for the first time the rapid temporal development of inspiratory flow during normal inspiration and dramatically so during sniffing. Variations in flow profile were recorded across a cohort of subjects for conditions of normal inspiration, sniffing and smelling. Sinonasal gas exchange is of particular interest given the common occurrence of sinus pathologies. Here short half-life Krypton imaging has been used to investigate gas exchange between the maxillary sinus and the nasal cavity. It has been shown that the technique can provide quantitative assessment of volume flow rate in a model, demonstrating the rapid venting associated with an accessory ostium.
Oral history interview with Leo Calvin Rosten, 1959
Publisher: name: Columbia University
Year: 2020
Subjects: Authors
Screenwriters
Motion pictures
Politics in motion pictures
Motion pictures--Production and direction
Pressure groups

description: Hollywood in the late 1930s: how movies are made, what influences their content, what kinds of people make movies, specifics about the movie making process; political climate in Hollywood; influence of pressure groups; anti-semitism and racism; employment practices; recollections of Harry and Jack Warner; comparison of major studios. Audio is comprised of narrator's excerpts from the Westinghouse Broadcasting Company's radio program series "Memoirs of the Movies"
Precession of isolated neutron stars I: Effects of imperfect pinning
Creators: name: Sedrakian, Armen
name: Wasserman, Ira
name: Cordes, James M.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We consider the precession of isolated neutron stars in which superfluid is not pinned to the stellar crust perfectly. In the case of perfect pinning, Shaham (1977) showed that there are no slowly oscillatory, long-lived modes. When the assumption of perfect pinning is relaxed, new modes are found that can be long-lived, but are expected to be damped rather than oscillatory, unless the drag force on moving superfluid vortex lines has a substantial component perpendicular to the direction of relative motion. The response of a neutron star to external torques, such as the spindown torque, is also treated. We find that when computing the response of a star to perturbations, assuming perfect coupling of superfluid to normal matter from the start can miss some effects.
description: 38 pages, uses aaspp4.sty, minor corrections; Final version to be published in ApJ