title: ÐÑÐ¾ÑÐ¸Ð²Ð¾Ð²Ð¸ÑÑÑÐ½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð² Ð¿ÑÐ¸ÑÐ¾Ð´Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð¸ÑÑ Ð¾Ð¶Ð´ÐµÐ½Ð¸Ñ Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ Ð²Ð¸ÑÑÑÐ° Ð³ÐµÑÐ¿ÐµÑÐ° ÑÐµÐ»Ð¾Ð²ÐµÐºÐ° Ð¿ÐµÑÐ²Ð¾Ð³Ð¾ ÑÐ¸Ð¿Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Antiviral activity of drugs of natural origin against the human herpes virus type 1
Creators: name: Ð Ð°Ð·Ð³ÑÐ»ÑÐµÐ²Ð°, ÐÐ°ÑÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: Ð²Ð¸ÑÑÑ Ð¿ÑÐ¾ÑÑÐ¾Ð³Ð¾ Ð³ÐµÑÐ¿ÐµÑÐ° Ð¿ÐµÑÐ²Ð¾Ð³Ð¾ ÑÐ¸Ð¿Ð°
Ð°ÑÐ¸ÐºÐ»Ð¾Ð²Ð¸Ñ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÑ Ð¿ÑÐ¸ÑÐ¾Ð´Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð¸ÑÑ Ð¾Ð¶Ð´ÐµÐ½Ð¸Ñ
Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð²Ð¸ÑÑÑÐ½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ
ÑÐ¸ÑÐ¾ÑÐ¾ÐºÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ
Ð¸Ð½Ð´ÐµÐºÑ Ñ Ð¸Ð¼Ð¸Ð¾ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸
Ð¶Ð¸Ð·Ð½ÐµÐ½Ð½ÑÐ¹ ÑÐ¸ÐºÐ» Ð²Ð¸ÑÑÑÐ°
ÐÐ¢Ð¢-ÑÐµÑÑ
herpes simple virus type 1
acyclovir
drugs of natural origin
antiviral activity
cytotoxic effect
index of chemotherapeutic activity
viral life cycle
MTT-test

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð²Ð¸ÑÑÑÐ½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð² Ð¿ÑÐ¸ÑÐ¾Ð´Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð¸ÑÑÐ¾Ð¶Ð´ÐµÐ½Ð¸Ñ Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ Ð²Ð¸ÑÑÑÐ° Ð¿ÑÐ¾ÑÑÐ¾Ð³Ð¾ Ð³ÐµÑÐ¿ÐµÑÐ° Ð¿ÐµÑÐ²Ð¾Ð³Ð¾ ÑÐ¸Ð¿Ð°. ÐÑÐ¿Ð¾Ð»ÑÐ·ÑÑ Ð¼ÐµÑÐ¾Ð´Ñ in vitro, Ð±ÑÐ»Ð° Ð¾ÑÐµÐ½ÐµÐ½Ð° Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð²Ð¸ÑÑÑÐ½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ 69 Ð²ÐµÑÐµÑÑÐ² ÑÐ°ÑÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð¸ÑÑÐ¾Ð¶Ð´ÐµÐ½Ð¸Ñ Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¸Ñ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ»Ð¸ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ñ Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ð½ÑÐµ Ð´Ð»Ñ Ð´Ð°Ð»ÑÐ½ÐµÐ¹ÑÐµÐ³Ð¾ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð²ÐµÑÐµÑÑÐ²Ð°: Ð¿ÑÐµÐ¿Ð°ÑÐ°Ñ 76 (ÑÐºÑÑÑÐ°ÐºÑ ÑÐ¾Ð·Ð¼Ð°ÑÐ¸Ð½Ð°), ÑÐ°Ð±Ð¾ÑÐ°ÑÑÐ¸Ð¹ ÐºÐ°Ðº Ð¸ Ð¿ÑÐ¾ÑÐ¸Ð»Ð°ÐºÑÐ¸ÑÐµÑÐºÐ¾Ðµ ÑÑÐµÐ´ÑÑÐ²Ð¾, ÑÐ°Ðº Ð¸ Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÐ¾Ñ ÑÐ°ÑÐ¿ÑÐ¾ÑÑÑÐ°Ð½ÐµÐ½Ð¸Ñ Ð²Ð¸ÑÑÑÐ½ÑÑ ÑÐ°ÑÑÐ¸Ñ Ð² ÑÐ¶Ðµ Ð·Ð°ÑÐ°Ð¶ÑÐ½Ð½ÑÑ ÐºÐ»ÐµÑÐºÐ°Ñ; ÐºÐ¾Ð¼Ð±Ð¸Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¹ Ð¿ÑÐµÐ¿Ð°ÑÐ°Ñ, ÑÐ¾ÑÑÐ¾ÑÑÐ¸Ð¹ Ð¸Ð· ÑÐºÑÑÑÐ°ÐºÑÐ° ÐºÑÐ°ÑÐ½Ð¾Ð³Ð¾ ÐºÐ¾ÑÐ½Ñ Ð¸ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ° ÐºÐ°ÑÐ±Ð¾Ð¿Ð¾Ð» 2020-Ð¼Ð¾Ð´Ð¸ÑÐ¸ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð³Ð¾, Ð¿ÑÐ¾ÑÐ²Ð¸Ð²ÑÐµÐ³Ð¾ ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾ÑÑÑ Ð¿ÑÐµÐ´Ð¾ÑÐ²ÑÐ°ÑÐ°ÑÑ Ð²Ð¸ÑÑÑÐ½ÑÑ ÑÐµÐ¿Ð»Ð¸ÐºÐ°ÑÐ¸Ñ Ð¸ ÑÐ°ÑÐ¿ÑÐ¾ÑÑÑÐ°Ð½ÐµÐ½Ð¸Ðµ, Ð¾Ð³ÑÐ°Ð½Ð¸ÑÐ¸Ð²Ð°Ñ Ð¿ÑÐ¾Ð½Ð¸ÐºÐ½Ð¾Ð²ÐµÐ½Ð¸Ðµ Ð²Ð¸ÑÑÑÐ° Ð² ÐºÐ»ÐµÑÐºÑ Ð¸/Ð¸Ð»Ð¸ Ð¼ÐµÐ¶ÐºÐ»ÐµÑÐ¾ÑÐ½Ð¾Ðµ ÑÐ°ÑÐ¿ÑÐ¾ÑÑÑÐ°Ð½ÐµÐ½Ð¸Ðµ. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ Ð¼Ð¾Ð³ÑÑ Ð±ÑÑÑ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ñ Ð´Ð»Ñ Ð´Ð°Ð»ÑÐ½ÐµÐ¹ÑÐµÐ¹ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð³ÐµÑÐ¿ÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð².
description: The given work is devoted to the study of the antiviral activity of drugs of natural origin against the herpes simplex virus type 1. Using in vitro methods, the antiviral activity of 69 substances of natural origin was evaluated. As a result of the work, the most promising substances for further study were identified: preparation 76 (rosemary extract), which works both as a prophylactic agent and as an inhibitor of the spread of viral particles in already infected cells; a combined preparation consisting of a red root extract and a polymer carbopol 2020-modified, which has shown the ability to prevent viral replication and spread, limiting the penetration of the virus into the cell and / or intercellular spread. The results of this work can be used for further development of antiherpetic drugs.