cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Environment benign synthesis of 5-acyl-4-hydroxypyridin-2(1H)-one derivatives as antioxidant and α-amylase inhibitors
Creators: name: Yadav, Neelam
name: Kumar, Ravi
name: Sangwan, Sarita
name: Dhanda, Vidhi
name: Duhan, Anil
name: Sindhu, Jayant
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Space Science
Medicine
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Oxidative stress, caused by postprandial activities, is a major global health issue causing chronic diseases like diabetes mellitus, cancer, and asthma. Therefore, it was envisaged to design and synthesize a series of substituted 4-hydroxypyridine-2(1 h)-ones in order to develop new molecules that can reduce oxidative stress and modulate α-amylase activity also. An environmentally benign, solvent and catalyst free, natural product inspired synthesis of 4-hydroxypyridin-2(1 h)-one derivatives has been developed. The synthetic analogues were evaluated in vitro α-amylase activity and antioxidant potential. Among all the synthesized compounds, 4a, 4c, and 4d displayed many folds higher antioxidants activity than the standard, BHT. The in vitro α-amylase inhibition was found to be moderate with IC50 values ranging from 5.48 to 9.31 mm as compared to the standard acarbose (IC50 = 0.65 mm). The most active compound against α-amylase 4c was further investigated for its binding affinity within the active site of the enzyme and the kinetics studies revealed probable uncompetitive mode of inhibition. Compound 4a was found to be promising antioxidant and 4c as a good α-amylase inhibitor. These compounds could pave the way for development of new α-amylase inhibitors with antioxidant capabilities thereby effectively mitigating diabetes mellitus.
Rhynchonema undetermined
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Monhysterida
Xyalidae
Rhynchonema
Rhynchonema undetermined

description: Rhynchonema sp.
Ainslie, ACT. 1 life stage unrecorded. 11.5.89
Bass Strait, OFFSHORE. Continental Shelf. Shell grit substrate. 4 males; 1 female. 10.1.87 Batemans Bay, NSW. Littoral Sand substrate. 2 males. 17.8.78
Cronulla, NSW. Sand. 19 life stage unrecorded. 6.5.77
Lorne, VIC. Littoral Sand substrate. 1 life stage unrecorded. 2.10.91
Lorne, VIC. Sub-littoral Sand substrate. 1 female. Date unrecorded.
Pathaya, THAILAND. 1 male; 4 females. 2.9.85
Rapid Creek, NT. Littoral Sand substrate. 5 males; 10 females; 1 life stage unrecorded. 19.10.92; 31.7.88; 30.9.88 Seaspray, VIC. Littoral Sand substrate. 1 female. 3.10.86
South Moruya, NSW. Littoral Sand substrate. 2 males; 1 female ..2.98; 14.3.98
Tomakin, NSW. Littoral Sand substrate. 1 male. 28.1.86
Locality unrecorded, Australia. 1 life stage unrecorded. Date unrecorded.
Genus Robustnema Nicholas, 1996
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on pages 88-89, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
Design and synthesis of new nicotinamides as immunomodulatory VEGFR-2 inhibitors and apoptosis inducers
Creators: name: Yousef, Reda G
name: Eissa, Ibrahim H
name: Elkady, Hazem
name: Mehany, Ahmed B M
name: Abo-Saif, Mariam Ali
name: Radwan, Mohamed M
name: ElSohly, Mahmoud A
name: Ibrahim, Ibrahim M
name: Elwan, Alaa
name: El-Zahabi, Mohamed Ayman
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Biochemistry
Medicine
Cell Biology
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Background: Nicotinamide-based VEGFR-2 inhibitors have good contribution in drug discovery. Aim: Development of novel nicotinamides as VEGFR-2 inhibitors. Methods: different in vitro and in silico assays were conducted to evaluate the VEGFR-2 inhibition and cytotoxicity. Results: Compound 16c displayed strongest anti-VEGFR-2 potentiality and good anti-proliferative effects. Compound 16c enhanced apoptosis and caused cell cycle arrest in the Pre-G1 and S phases. Compound 16c boosted the level of the apoptotic caspase-3 and inhibited the level of TNF-α and IL-6 in tumor cells. Molecular docking and molecular dynamics (MD) simulations indicated the outstanding binding potential of compound 16c against VEGFR-2. Conclusion: Compound 16c is a good candidate for the creation of a novel antiangiogenic lead anticancer medication. New nicotinamides have been designed and synthesized as VEGFR-2 inhibitors. VEGFR-2 inhibitory activity and cytotoxic effect against HepG2, HCT-116 and MCF-7 were evaluated. The effects on cell cycle and apoptosis were assessed. The immunomodulatory effects of the most active compound were tested against IL-2. TNF-α and Caspase-3 in MCF-7 cells. In silico docking, MD simulation, ADMET and toxicity studies were carried out.
Autophagy degradation: a promising dimension in drug discovery for neurodegenerative diseases
Creators: name: Liu, Shuai-Jiang
name: Cai, Chenxi
name: Zhu, Hong-Ping
name: Li, Xiang
name: Han, Bo
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy

description: Autophagy degradation: a promising dimension in drug discovery for neurodegenerative diseases
Robustnema fosteri Nicholas 1996
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Monhysterida
Xyalidae
Robustnema
Robustnema fosteri

description: Robustnema fosteri Nicholas, 1996
Fullarton Cove, NSW. Littoral Mud substrate. Rhizophora host plant. 5 males; 5 females; 3 juveniles. 10.3.82
Pine River Estuary, QLD. Littoral Mud substrate. Mangrove host plant. 14 males; 16 females; 11 juveniles. 30.8.86
Genus Scaptrella Cobb, 1917
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on page 89, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
In-vitro and in-silico assessment of thiazole-thiazolidinone derivatives as selective inhibitors of urease and α-glucosidase
Creators: name: Khan, Yousaf
name: Hussain, Rafaqat
name: Rehman, Wajid
name: Khan, Shoaib
name: Maalik, Aneela
name: Iqbal, Tayyiaba
name: Aziz, Tariq
name: Afridi, Muhammad Irfan
name: Alharbi, Metab
name: Alasmari, Abdullah F
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Current research work aims to synthesize hybrid compounds with a thiazole-thiazolidinone structure, as potent inhibitors of urease and α-glucosidase enzymes. These compounds were characterize through1HNMR,13CNMR and HREI-MS techniques. These compounds were also evaluated for their potential to inhibit urease and α-glucosidase enzymes for the treatment of urinary tract infections (UTIs) and diabetes treatments. Moreover, molecular docking and ADMET analysis was carried out to confirm biological outcomes. Compounds-4 (IC50 = 1.80 ± 0.80 and 3.61 ± 0.59 μM against urease and α-glucosidase, respectively) exhibited significant effectiveness in inhibiting the activity of both enzymes in comparison to the conventional inhibitors thiourea and acarbose. Molecular docking experiments showed that potent compounds exhibited favorable binding orientations in the active sites of urease and α-glucosidase playing a pivotal role in inhibition profile of these compounds. These compounds were also investigated for their drug likeness and were found with desirable attributes for pharmaceutical development. Based on the findings of this research, these compounds have the potential to be developed into effective anti-diabetic and anti-urease treatments in the future.
Scaptrella undetermined
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Monhysterida
Xyalidae
Scaptrella
Scaptrella undetermined

description: Scaptrella sp.
Off Crocodile Island, OFFSHORE. 27m deep. Sandy mud substrate. 2 males. 7.5.79
Genus Stylotheristus Lorenzen, 1973b
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on page 89, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
Design and synthesis of new nicotinamides as immunomodulatory VEGFR-2 inhibitors and apoptosis inducers
Creators: name: Yousef, Reda G
name: Eissa, Ibrahim H
name: Elkady, Hazem
name: Mehany, Ahmed B M
name: Abo-Saif, Mariam Ali
name: Radwan, Mohamed M
name: ElSohly, Mahmoud A
name: Ibrahim, Ibrahim M
name: Elwan, Alaa
name: El-Zahabi, Mohamed Ayman
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Medicine
Cell Biology
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Background: Nicotinamide-based VEGFR-2 inhibitors have good contribution in drug discovery. Aim: Development of novel nicotinamides as VEGFR-2 inhibitors. Methods: different in vitro and in silico assays were conducted to evaluate the VEGFR-2 inhibition and cytotoxicity. Results: Compound 16c displayed strongest anti-VEGFR-2 potentiality and good anti-proliferative effects. Compound 16c enhanced apoptosis and caused cell cycle arrest in the Pre-G1 and S phases. Compound 16c boosted the level of the apoptotic caspase-3 and inhibited the level of TNF-α and IL-6 in tumor cells. Molecular docking and molecular dynamics (MD) simulations indicated the outstanding binding potential of compound 16c against VEGFR-2. Conclusion: Compound 16c is a good candidate for the creation of a novel antiangiogenic lead anticancer medication. New nicotinamides have been designed and synthesized as VEGFR-2 inhibitors. VEGFR-2 inhibitory activity and cytotoxic effect against HepG2, HCT-116 and MCF-7 were evaluated. The effects on cell cycle and apoptosis were assessed. The immunomodulatory effects of the most active compound were tested against IL-2. TNF-α and Caspase-3 in MCF-7 cells. In silico docking, MD simulation, ADMET and toxicity studies were carried out.
New 4-amino-3-chloro benzoate ester derivatives as EGFR inhibitors: synthesis, in silico and biological analyses
Creators: name: Al Rahim, Nedaa A. Abd
name: Mahmood, Ammar A. Razzak
name: Tahtamouni, Lubna H.
name: AlSakhen, Mai F.
name: Yasin, Salem R.
name: Saleh, Abdulrahman M.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Medicine
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: The main goal of this study was to synthesize new derivatives of 4-amino-3-chloro benzoate ester, including 1,3,4-oxadiazole derivatives (N3a-d), benzohydrazone derivatives (N4a-c), and hydrazine-1-carbothioamide derivatives (N5a-d) that target epidermal growth factor receptor (EGFR) tyrosine kinase. The new derivatives were characterized using various spectroscopic techniques. Docking studies were used to investigate the binding patterns to EGFR, and the anti-proliferative properties were tested in vitro. In silico analysis showed that the hydrazine-1-carbothioamide derivatives (N5a-d) had the best matching pattern with EGFR pharmacophoric queries compared to erlotinib, exhibited a favorable safety profile, and showed the best stability among the tested compounds. Compound N5a induced cytotoxicity in the three cancer cell lines tested (A549, HepG2, and HCT-116), by targeting EGFR and activating caspase 3 and caspase 8, therefore, inducing the extrinsic apoptotic pathway. The results of this study show that compound N5a is a promising cytotoxic compound that inhibits the tyrosine kinase activity of EGFR.
Stylotheristus mutilus Lorenzen 1977
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Monhysterida
Xyalidae
Stylotheristus
Stylotheristus mutilus

description: Stylotheristus mutilus (Lorenzen, 1973b) Lorenzen, 1977
Candlagan, NSW. 1 life stage unrecorded. 14.7.79
Genus Theristus Bastian, 1865
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on page 89, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
Theristus interstitialis Warwick 1970
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Monhysterida
Xyalidae
Theristus
Theristus interstitialis

description: Theristus interstitialis Warwick, 1970
Candlagan Creek Estuary, NSW. Littoral Mud substrate. Mangrove host plant. 3 males; 1 female. 10.12.78;.12.78; 14.7.79
Clyde River, NSW. 1 male ..12.84
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on page 89, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
Theristus (Penzancia) de Man 1889
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Monhysterida
Xyalidae
Theristus

description: Theristus (Penzancia) sp.
Broulee Beach, NSW. Littoral Sand substrate. 2 males; 1 female; 2 juveniles. Date unrecorded.
Kioloa, NSW. Littoral Sand substrate. 1 male; 2 females. 23.2.76
Lorne, VIC. Littoral Sand substrate. 9 males; 11 female; 5 juveniles; 2 life stage unrecorded..10.91; 2.10.01 Rapid Creek, NT. Littoral Sand substrate. 1 male; 1 female. 31.7.80
South Moruya, NSW. Littoral Sand substrate. 1 female. 10.5.97
Locality unrecorded, Australia. 1 life stage unrecorded. Date unrecorded.
Locality unrecorded, NSW. 1 female; 1 life stage unrecorded. Date unrecorded.
Genus Trichotheristus Wieser, 1956
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on page 90, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
Coleta de dados:  manual de procedimentos no setor de processamento técnico em bibliotecas universitárias: um estudo de caso na biblioteca Professora Etelvina Lima
Creators: name: BRUM, LILIAN MORAIS
Publisher: name: Zenodo
Year: 2024

description: Planilha de Registro dos resultados da coleta de dados para a formulação da Dissertação: "MANUAL DE PROCEDIMENTOS NO SETOR DE PROCESSAMENTO TÉCNICO EM BIBLIOTECAS UNIVERSITÁRIAS: ESTUDO DE CASO NA BIBLIOTECA PROFESSORA ETELVINA LIMA" a ser defendida em 2025. 

 
description: Agradecimentos

Agradecemos à Fundação de Amparo à Pesquisa do Estado de Minas Gerais (Fapemig), pela bolsa de pesquisa de mestrado.
A novel image segmentation method based on spatial autocorrelation identifies A-type potassium channel clusters in the thalamus
Creators: name: Dávid, Csaba
name: Giber, Kristóf
name: Kerti-Szigeti, Katalin
name: Köllő, Mihály
name: Nusser, Zoltan
name: Acsady, Laszlo
Publisher: name: The Francis Crick Institute
Year: 2025
Subjects: classificationCode: Neurosciences
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: Microfabrication & Bioengineering
subject: Microfabrication & Bioengineering
classificationCode: Ecology,Evolution & Ethology
subject: Ecology,Evolution & Ethology
classificationCode: Computational & Systems Biology
subject: Computational & Systems Biology

description: Unsupervised segmentation in biological and non-biological images is only partially resolved. Segmentation either requires arbitrary thresholds or large teaching datasets. Here, we propose a spatial autocorrelation method based on Local Moran’s I coefficient to differentiate signal, background, and noise in any type of image. The method, originally described for geoinformatics, does not require a predefined intensity threshold or teaching algorithm for image segmentation and allows quantitative comparison of samples obtained in different conditions. It utilizes relative intensity as well as spatial information of neighboring elements to select spatially contiguous groups of pixels. We demonstrate that Moran’s method outperforms threshold-based method in both artificially generated as well as in natural images especially when background noise is substantial. This superior performance can be attributed to the exclusion of false positive pixels resulting from isolated, high intensity pixels in high noise conditions. To test the method’s power in real situation, we used high power confocal images of the somatosensory thalamus immunostained for Kv4.2 and Kv4.3 (A-type) voltage-gated potassium channels in mice. Moran’s method identified high-intensity Kv4.2 and Kv4.3 ion channel clusters in the thalamic neuropil. Spatial distribution of these clusters displayed strong correlation with large sensory axon terminals of subcortical origin. The unique association of the special presynaptic terminals and a postsynaptic voltage-gated ion channel cluster was confirmed with electron microscopy. These data demonstrate that Moran’s method is a rapid, simple image segmentation method optimal for variable and high noise conditions.
Trichotheristus undetermined
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Monhysterida
Xyalidae
Trichotheristus
Trichotheristus undetermined

description: Trichotheristus sp.
Broulee, NSW. Littoral Sand substrate. 4 juveniles; 2 life stage unrecorded..4.84
Genus Xenolaimus Cobb, 1920
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on page 90, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
Xenolaimus undetermined
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Monhysterida
Xyalidae
Xenolaimus
Xenolaimus undetermined

description: Xenolaimus sp.
Candlagan, NSW. 1 life stage unrecorded. 11.1.77
Candlagan Creek Estuary, NSW. Littoral Sand substrate. 1 male; 4 females; 2 juveniles. 30.8.06; 8.12.06
Cronulla, NSW. 1 life stage unrecorded. 28.11.77
Genus Xyala Cobb, 1920
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on page 90, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
Xyala brevibucca Stewart & Nicholas 1994
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Monhysterida
Xyalidae
Xyala
Xyala brevibucca

description: Xyala brevibucca Stewart & Nicholas, 1994
Broulee, NSW. Littoral Sand substrate. 3 males; 2 females; 4 juveniles. Date unrecorded.
Kioloa, NSW. Littoral Sand substrate. 1 male; 4 females; 4 juveniles. 27.11.86
Southport, QLD. Littoral Sand substrate. 2 males; 13 females; 3 juveniles. 31.8.86
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on page 90, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
Xyala hanleyi Stewart & Nicholas 1994
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Monhysterida
Xyalidae
Xyala
Xyala hanleyi

description: Xyala hanleyi Stewart & Nicholas, 1994
Darwin Museum River Mouth, NT. Avicennia host plant. 1 male. 31.7.88
Rapid Creek, NT. Littoral Sand substrate. 1 female; 1 juvenile. 31.7.86
Southport, QLD. Littoral Sand substrate. 6 males; 3 females; 2 juveniles. 31.8.86
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on page 91, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
Mainzed Newsflash 1/2018 - 20. März 2018
Creators: name: Klammt, Anne
Publisher: name: Zenodo
Year: 2018
Subjects: subject: mainzed Newsletter
subject: Mainz
subject: Digital Humanities
subject: https://de.wikipedia.org/w/index.php?title=Digital_Humanities&oldid=174210652

description: Newsletter des Mainzer Zentrums für Digitalität in den Geistes- und Kulturwissenschaften (mainzed)
Lebih bisa saja Kurang: Menghadapi Paradoks Pilihan Kurikulum Merdeka
Creators: name: Kristanto, Yosep Dwi
Publisher: name: figshare
Year: 2022
Subjects: subject: 130313 Teacher Education and Professional Development of Educators
subject: FOS: Educational sciences
subject: 160506 Education Policy
subject: FOS: Political science
subject: Education

description: Kebijakan Merdeka Belajar telah memberikan lebih banyak kebebasan bagi para guru matematika untuk lebih memihak kepada peserta didiknya. Namun, seperti halnya segala hal yang berlebihan umumnya tidak baik, apakah hal yang sama juga berlaku untuk Kurikulum Merdeka? Dan apa yang bisa dilakukan pemangku kepentingan terkait untuk menyikapinya?
Xyala striata Cobb 1920
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Monhysterida
Xyalidae
Xyala
Xyala striata

description: Xyala striata Cobb, 1920
Locality unrecorded, Australia. 1 life stage unrecorded. Date unrecorded.
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on page 91, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
Xyala undetermined
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Monhysterida
Xyalidae
Xyala
Xyala undetermined

description: Xyala sp.
Bangburt, THAILAND. 2 males; 2 females. 8.7.88
Bass Strait, OFFSHORE. Continental Shelf. 1 juvenile. 10.1.87
Cronulla, NSW. Sub-littoral Sand substrate. 12 life stage unrecorded. 6.5.77
Kioloa, NSW. Littoral Sand substrate. 20 life stage unrecorded. 27.11.86; 27.2.76; 23.2.76; 24.2.76; 25.2.76;.2.76 Pathaya, THAILAND. 1 life stage unrecorded. 10.7.88
Rosedale, NSW. 1 life stage unrecorded. 13.4.88
South Moruya, NSW. Littoral Sand substrate. 11 life stage unrecorded..7.97; 10.1.98; 16.10.88
Locality unrecorded, Australia. 3 juveniles. Date unrecorded.
Locality unrecorded, ACT. 13.12.04
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on page 91, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
Technology adoption in developing countries: the impact of the sharing economy
Creators: name: Putra, Yuniarti Hidayah Suyoso
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This study examines the adoption of the sharing economy platform Gojek in Indonesia and its impact on small and medium enterprises (SMEs) in moving from an offline to an online business model. The study examines the adoption of the sharing economy platform (Gojek), the reasons that SMEs continue to use the platform as well as the existing regulatory environment for the sharing economy. The study had three phases. The first phase collected data using semi-structured interviews with 29 SMEs to gain an in-depth understanding of the critical success factors and barriers in adopting Gojek. Results show that the critical success factors for adopting the platform were performance expectancy, effort expectancy, social influence, enjoyment, and economic benefits. However, some of these critical success factors, such as facilitating conditions and platform quality, were also barriers. Other barriers included privacy risks and security risks. The second phase of the study examined empirically the factors influencing the extent of use of the sharing economy platform and its subsequent impact on performance by surveying 346 SMEs. The results show that facilitating conditions, privacy risks, security risks, and platform quality are positively associated with extent of use of the sharing economy platform. A key finding was that the extent of use of the platform is positively associated with job and business performance. The third phase of the study analyzed the sharing economy policy and regulatory environment in Indonesia using government websites and semi-structured interviews with government department representatives. Findings show that the existing policies and regulations are inadequate for managing the complexities of the sharing economy, including mitigating its negative impact on society. Vll This study contributes to the literature by extending Unified Theory of Acceptance and Use of Technology (UTAUT) theories by incorporating sharing economy factors. This helps us to help us better understand the benefits and limitations of adoption of the sharing economy, in order to better gauge the impact for SMEs in moving from an offline to an online business model. A conceptual framework was developed to identify the social, technological, and political factors that governments should consider when developing policies and regulations for the sharing economy.
Xyala undetermined
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Monhysterida
Xyalidae
Xyala
Xyala undetermined

description: Xyala sp. “ pathaya ”
Bangburt, THAILAND. 1 male; 2 females. 8.7.88
Chumporn, THAILAND. 1 male; 2 females. 7.7.88
Huahin, THAILAND. 1 male; 1 female. Date unrecorded.
Pathaya, THAILAND. 2 females. 2.9.85
Superorder Plectica Hodda, 2007
Order Leptolaimida Hodda, 2007
Suborder Leptolaimina Lorenzen, 1981
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on page 91, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
The making of modern Samoa: traditional authority and colonial administration in the history of Western Samoa
Creators: name: Meleiseā, Mālama
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Since independence in January 1962 several controversial court cases have exposed the dilemma which the Western Samoan government is facing balancing fa'a Samoa (Samoan customs and traditions) and Western rational-legal systems of authority. Western Samoa’s present legislative structure was adopted in 1962 providing two systems of legal resort to Samoans. When cases or disputes between individuals, ‘āiga (descent groups), nu’u (village), itū/mālō (district) and the national government are referred to the country’s court systems, parties may invoke either of these sources of authority to legitimise their actions and claims. The problem is particularly severe in the proceedings of the Land and Titles Court, a body legally constituted to deal with matters of traditional significance.
The Gift of the Tongue - Investigating Spoken Voice Intervention for Interpreting Students
Creators: name: GU, Yingzhi
Publisher: name: Monash University
Year: 2022
Subjects: Translation and interpretation studies

description: This study examines the effects of spoken-voice intervention on students’ vocal performance in relation to the delivery of interpreting. This study adopted a mixed-method design with both quantitative and qualitative approaches in the description of learners’ performance. The data analysis shows that the spoken-voice intervention groups recorded significantly higher levels of vocal performance than the non-intervention group. This study concluded that the spoken-voice intervention approach yielded a highly positive intervention outcome, resulting in significant levels of improvement in vocal performance in relation to the delivery of interpreting delivery for the 3 intervention groups.
Ceramonema undetermined
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Plectida
Ceramonematidae
Ceramonema
Ceramonema undetermined

description: Ceramonema sp.
Bangburt, THAILAND. 1 life stage unrecorded. 8.7.88
Bass Strait, OFFSHORE. Continental Shelf. Shell grit substrate. 2 juveniles. 30.1.87
Broulee, NSW. Littoral Sand substrate. 2 males; 9 juveniles; 3 life stage unrecorded. 3.08.80
Cronulla, NSW. Sub-littoral Sand substrate. 2 life stage unrecorded. 6.5.77
Cronulla, NSW. 10m depth. 3 life stage unrecorded. 23.11.77
Cronulla, NSW. 25 m depth. 11 life stage unrecorded. 23.11.77
Darwin Museum River Mouth, NT. Avicennia host plant. 2 males; 1 female. 30.9.88; 19.3.88
Kioloa, NSW. Littoral Sand substrate. 1 male; 1 female; 2 juveniles; 2 life stage unrecorded. 16.11.80; 27.11.86;.2.76
Moruya, NSW. 1 male; 2 females; 1 juvenile; 1 life stage unrecorded. 2.09.1987
Pathaya, THAILAND. 1 life stage unrecorded. 10.7.88
Rapid Creek, NT. Littoral Sand substrate. 2 juveniles; 1 life stage unrecorded. 31.7.88; 19.10.92
Rosedale, NSW. Littoral Sand substrate. 3 females; 3 juveniles; 1 life stage unrecorded. 17.3.85; 17.5.85; 13.4.88 Seaspray, VIC. Littoral Sand substrate. 1 male; 1 juvenile. 3.10.86
South Moruya, NSW. Littoral Sand substrate. 3 males; 1 female; 2 juveniles; 1 life stage unrecorded. 19.11.98; 9.11.88; 2.12.87; 27.4.88
Tomakin, NSW. Littoral Sand substrate. 1 female. 11.11.86
Locality unrecorded, THAILAND. 1 life stage unrecorded. Date unrecorded.
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on pages 91-92, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
Ceramonema undetermined
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Plectida
Ceramonematidae
Ceramonema
Ceramonema undetermined

description: Ceramonema sp. “A”
Broulee, NSW. Littoral depth. 1 female; 3 juveniles. 3.08.80
Cronulla, NSW. 1 male. 12.5.77
Rosedale, NSW. Littoral Sand substrate. 9 males; 10 females; 10 juveniles; 6 life stage unrecorded. 17.3.85; 17.5.85; 10.6.85
South Moruya, NSW. Littoral Sand substrate. 1 male. 27.7.91
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on page 92, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
Newcastle University KITE Open Odonto - FinalReport Dec 2016
Creators: name: Valentine, Lucille
name: Wassall, Rebecca
name: Martin, Mike
name: Wilson, Rob
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 420308
subject: Health informatics and information systems

description: Open Source software development for Community Dental ServicesReport on the first phase of a project by OpenOdonto CIC to frame the functions, reach and purpose – discovering the user needs – of new, open source software that will be used in Community Dental Services, the providers of special care dentistry in the NHS in England. While the final goal of the whole project should be to develop fit for purpose open source software using an Agile software development methodology, the troublesome part of achieving this goal is defining what fit for purpose would look like.Our study focussed on developing a clear understanding, and vision, of what is really needed from software that will be used to support dentists, clinicians and administrators at Community Dental Services at NHS Trusts in England.We explored the barriers and facilitators to the involvement of Health IT in dentistry in person-centred care for special care dentistry with the NHS. Engaged a range of stakeholders in service innovation, defining prototype digital tools to improve the provision of dentistry for older people living in care homes.This involved working with a small number of purposively sampled ‘information rich’ participants, shadowing current practice, in-situ interviews and a series of co-design workshops.The co-design research captured the true user needs for digital tools in community-based dental services. Mapping, personas, storyboarding and narratives allowed stakeholders to engage with data and create new user journeys based on their collective experiences, especially activities that take a lot of time, are necessary for safe care, but are not currently recognised, captured, or rewarded.
Meetup.com: a cohesive tool for multicultural societies?
Creators: name: Zamanillo, Lourdes
Publisher: name: Monash University
Year: 2022
Subjects: Sociology of migration, ethnicity and multiculturalism
Multicultural, intercultural and cross-cultural studies
Communication technology and digital media studies

description: With a mixed-methods approach, this thesis explores the extent to which participation in a EBSN called Meetup allows members to form and maintain interethnic relationships in Melbourne, Australia. Results indicate that participation in Meetup allows members to form interethnic relationships, but not necessarily maintain them over time. Findings from this thesis suggest that shared leadership, increased quantity and quality of contact, and multi-channel and multi-activity engagement are key elements that could enhance relationship maintenance.
Ceramonema undetermined
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Plectida
Ceramonematidae
Ceramonema
Ceramonema undetermined

description: Ceramonema sp. “B”
Broulee, NSW. Littoral Sand substrate. 1 male; 4 juveniles; 3 life stage unrecorded. 3.8.80
Cronulla, NSW. 1 male; 1 female. 12.5.77; 6.5.77
Kioloa, NSW. Littoral Sand substrate. 2 males; 1 female. 16.11.80
Rosedale, NSW. Littoral Sand substrate. 1 male. 17.5.85
South Moruya, NSW. Littoral Sand substrate. 1 male. Date unrecorded.
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on page 92, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
From Abarodh to Mehfil: On Reading Colonial Bengal's Muslim Women Writers
Creators: name: Paul, Sreejata
Publisher: name: Monash University
Year: 2021
Subjects: Comparative and transnational literature
Literary theory
Stylistics and textual analysis
Literary studies not elsewhere classified
Gender studies not elsewhere classified

description: This thesis examines women writers indexed as 'Bengali' and 'Muslim' in the late colonial era and locates their exclusion (abarodh) from the hegemonic canon of Bengali literature. Reading against the grain of a literary modernity built around male Hindu writers' work, it introduces mehfii as a heuristic device that makes these women writers more accessible to present-day readers through their shared literary-cultural genealogies. Mehfii enables the discovery of wider networks of circulation and exchange in Asia and Africa, which these writers participate in and where their shared experiences, concerns, and politics emerge as the bases for interpersonal and empathetic dialogue.
Ceramonema undetermined
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Plectida
Ceramonematidae
Ceramonema
Ceramonema undetermined

description: Ceramonema sp. “C”
Cronulla, NSW. 1 female. 6.5.77
Kioloa, NSW. Littoral Sand substrate. 3 females. 16.11.80; 17.11.80
Rosedale, NSW. Littoral Sand substrate. 1 male. 17.5.85
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on page 92, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
Ceramonema undetermined
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Plectida
Ceramonematidae
Ceramonema
Ceramonema undetermined

description: Ceramonema sp. “D”
Kioloa, NSW. Littoral Sand substrate. 2 juveniles. 17.11.80
Genus Dasynemella Cobb, 1933
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on page 92, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
The Saudi teachers' identities in teaching english as an international language
Creators: name: Alshammari, Alya
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: This study investigates some Saudi university level English teachers’ attitudes towards the English as an International Language paradigm and its influence on their identities as English speakers and teachers. The study used a qualitative case study approach. The data was collected from six Saudi English teachers in College of Language and Translation at Princess Norah University, Saudi Arabia through in-depth semi-structured interviews. The study identified a strong relationship between identity construction as a legitimate speaker and teacher of English on the one hand, and embracing cultural and linguistic diversity of English on the other, which resulted in high self-confidence among some of the participants. The research findings revealed that the participants have different perceptions regarding EIL principles and the legitimacy of different varieties of English. Most interestingly, although all of them agreed upon the advantage of using EIL for international communication, the reasons given by participants varied based on their personal beliefs and experiences. Regarding their identity as owners of the language, it was a point of contradiction and ambivalence as most of them were not familiar with the concept of EIL and were used to the unitary view of the English language as exclusive to native speakers. The study provides some suggestions for Saudi English educators to raise their self-confidence through embracing the diverse and international view of the English language.
Disponibilité perçue des services du distributeurs : proposition d'une échelle de mesure dans la relation producteur -distributeur
Creators: name: Moshé Léopold TENDENG
name: Mohamed BADJI
Publisher: name: Zenodo
Year: 2025

description: La littérature marketing s’accorde sur la nécessité de bâtir des relations entre partenaires à l’échange stables et durable. L’émergence d’un marketing centre sur la relation traduit le paradigme de l’échange en s’appuyant sur la théorie de l’échange social et élargie son champ d’application dans le domaine de la grande distribution, des services et de l’industrie. La distribution au Sénégal est marquée par une difficulté de développement de la relation entre les producteurs et les distributeurs. A cela s’ajoute une mutation de l’environnement commercial de grande enseigne de distribution. Le choix du point de vente devient alors un enjeu stratégique dans la réalisation de performance commerciaux pour les PME de la transformation et la mise en place de relations pouvant garantir un succès commercial. La disponibilité perçue serait alors une variable déterminante à intégrer dans le processus de décision de ces entreprises et dans la recherche de partenariats commerciaux à long terme. Pour trouver les réponses au problème pose, nous avons recouru une enquête portant sur 323 producteurs qui a permis d’avoir un modèle structurel de la disponibilité perçue dans relation entre les producteurs et les distributeurs au Sénégal. Nos résultats révèlent un concept multidimensionnel très déterminant dans la mise en place d’une relation durable.
Dasynemella undetermined
Creators: name: Khudhir, Manda
name: Hodda, Mike
name: Nicholas, Evelyn
name: Campbell, Jennifer
name: Nicholas, Warwick L.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Plectida
Ceramonematidae
Dasynemella
Dasynemella undetermined

description: Dasynemella sp.
Broulee, NSW. Littoral Sand substrate. 13 males; 2 females. 3.8.80
Cronulla, NSW. 25m depth. 7 life stage unrecorded. 23.11.77
Cronulla, NSW. Sub-littoral Sand substrate. 1 male; 13 life stage unrecorded. 12.5.77; 23.11.77; 6.5.77
Darwin Museum River Mouth, NT. 1 male. 31.7.88
Kioloa, NSW. Littoral Sand substrate. 2 males; 2 females; 4 juveniles; 1 life stage unrecorded. 16.11.80; 17.11.80 Tomakin, NSW. Littoral Sand substrate.1 life stage unrecorded. 11.11.86
description: Published as part of Khudhir, Manda, Hodda, Mike, Nicholas, Evelyn, Campbell, Jennifer & Nicholas, Warwick L., 2023, A catalogue of the nematode slide collection from the late W. L. Nicholas held at National Research Collections Australia, CSIRO, pp. 1-109 in Zootaxa 5388 (1) on page 92, DOI: 10.11646/zootaxa.5388.1.1, http://zenodo.org/record/10390008
title: How to read German state archives differently: the case of the »Iraqi traveller« Yūnis Baḥrī (ca. 1901-1979) in a global frame
Creators: name: Riecken, Nils
Publisher: name: Leibniz-Zentrum Moderner Orient
Year: 2017
Subjects: subject: Yūnis Baḥrī
subject: Propaganda
subject: Arab nationalism
subject: National Socialism
subject: 020
subject: 300
subject: 910

description: ZMO Working Papers, no. 18
Molecular pathways in alcohol consumption and dependence : emphasis on gut-brain and neuroimmune signaling
Creators: name: Grantham, Emily Kathleen
name: 0000-0002-4501-3097
Publisher: name: The University of Texas at Austin
Year: 2021
Subjects: Alcohol
Neurobiology
Neuroimmune
Gut-brain
Interferon
Addiction

description: Alcohol use disorder (AUD) is a chronic, relapsing brain disease with few effective treatment options. Chronic alcohol abuse leads to cellular and molecular changes throughout the brain and body. These molecular adaptations, such as gene expression changes, drive the pathophysiology of AUD. Therefore, it is critical to profile and understand gene expression changes underlying the various components of AUD, such as voluntary alcohol consumption, alcohol dependence, and stress-induced alcohol consumption. Microarray and transcriptome studies have revealed neuroimmune signaling as a consistent and significant molecular pathway involved in the regulation of alcohol consumption and dependence, though the mechanisms for how this pathway modulates behavior are unclear. In addition, given the limited availability of FDA-approved therapies for AUD, novel approaches to targeting the brain are necessary. One promising approach for therapeutic development involves targeting anti-inflammatory signaling via the gut-brain axis. In the first part of this dissertation, I describe transcriptome changes caused by chronic alcohol exposure and stress in critical stress- and addiction-related brain regions, the nucleus of the solitary tract (NTS) and bed nucleus of the stria terminalis (BNST). Results from these experiments identify neuroimmune signaling, specifically type I interferon signaling, as an important dependence-related signaling pathway across the brain. Next, I show that pharmacologically manipulating type I interferon signaling affects addiction-related behaviors depending on the timing of drug administration. Finally, I take advantage of the neural connection between gut and brain to develop a novel drug delivery system that targets neuroimmune signaling and has the potential to reduce alcohol consumption. Altogether, this work provides new information about molecular drivers of alcohol dependence and consumption and lays a foundation for novel therapeutic development in the future.
title: From the Karakoram Mountains to the Gulf: migration, development and religion in the making of transnational spaces
Creators: name: Mato Bouzas, Antía
Publisher: name: Leibniz-Zentrum Moderner Orient
Year: 2018
Subjects: subject: Migration
subject: Karakoram Mountains
subject: Pakistan
subject: Kuwait
subject: 300

description: ZMO Working Papers, no. 21