cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mechanisms of resistance to targeted therapeutics in HRAS-mutant head and neck squamous cell carcinoma
Creators: name: Frances Massey
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: HRAS-mutant head and neck squamous cell carcinoma (HNSCC) is a rare and deadly cancer type, for which effective treatments are currently lacking. HRAS-mutant HNSCC patients have shown sensitivity to the farnesyl transferase inhibitor (FTI) tipifarnib clinically. Tipifarnib inhibits the membrane association of HRAS, a small GTPase that activates many cell-signaling pathways that are associated with the growth, maintenance and survival of cancer cells. We investigated whether treatment of HRAS-mutant HNSCC cell lines with tipifarnib induced common mechanisms of resistance to cancer therapeutics. Indeed, we found that proteins in the MAPK and PI3K-AKT-mTOR signaling pathways were activated upon treatment with tipifarnib, suggesting compensatory activation of these pathways as a possible mechanism of resistance in our cell lines. We next tested whether tipifarnib induced epithelial to mesenchymal transition (EMT). EMT results in improved migratory ability, increased invasiveness, and enhanced resistance to apoptosis. Using immunoblotting and immunofluorescence microscopy, we observed an upregulation in markers of EMT upon treatment with tipifarnib. A subset of HRAS-mutant HNSCC cell lines have shown sensitivity to the inhibition of ERK, with the ERK inhibitor SCH772984, in combination with other therapeutics. ERK is a downstream effector of HRAS. Previous studies have shown that induction of autophagy is a mechanism of resistance to ERK inhibition with SCH772984 treatment in some RAS-mutant cancers. Autophagy is the process through which cells recycle proteins and cytoplasmic organelles in response to stress. We found that SCH772984 induced autophagic flux. We did not observe an increase in apoptosis upon simultaneous inhibition of autophagy and ERK, however, suggesting that autophagy may not be a mechanism of resistance to ERK inhibition in these cell lines.  Overall, these results suggest several possible mechanisms of resistance of HRAS-mutant HNSCC cell lines to targeted therapeutic agents, which could help inform future treatment of HRAS-mutant HNSCC.
Manifest per a una comunicació científica responsable
Creators: name: García, Esther Sánchez
name: Menéndez, Óscar
name: Revuelta, Gema
name: Simón Perera
name: Masnou, Anna May
name: Armentia, Javier
name: Rodríguez, Estibaliz Urarte
name: González, Laura Ferrando
name: Monasor, Ángela
name: Nájera, Alberto
name: Magalhães, Joana
name: Diez, Daniela
name: Castejón, Francisco
name: Ma. Paulina Naranjo Peñaherrera
name: Llorente, Carolina
Publisher: name: Zenodo
Year: 2023

description: La comunicació de la ciència ha de prendre partit La pau és molt més que la manca de violència. El Campus Gutenberg-CosmoCaixa 2022, celebrat al setembre a Barcelona, va ser una oportunitat única per parlar sobre com la comunicació de la ciència pot ajudar a generar una veritable cultura de la pau. Sabem que la ciència no sempre ajuda a la pau. I, quan això passa, què fem les persones que comuniquem ciència? Callem o ho expliquem a la nostra audiència? Creiem que no sempre prenem partit per la pau. El Manifest per a una comunicació científica responsable és el resultat del debat sobre aquestes idees. Creiem que la comunicació de la ciència es pot convertir en una eina per ajudar a eliminar la desigualtat, la injustícia, la pobresa i altres amenaces a la pau. Però, per aconseguir-ho, hem de prendre partit i passar a l'acció. Pots adherir-te al manifest omplint aquest formulari.
Maestri e maestre di ginnastica nell’Italia dell’Ottocento
Creators: name: Elia, Domenico Francesco Antonio
Publisher: name: Gli Argonauti. Rivista di Studi Storico-Educativi e Pedagogici
Year: 2025

description: Il presente contributo, a partire dalla definizione di un modello comune sportivo per l’area «latina» europea, intende riflettere sulla figura dell’insegnante di ginnastica in Italia in Età liberale. Attraverso la lettura dei dati statistici concernenti i docenti di questa disciplina in servizio nell’anno scolastico 1885/1886, conservati presso l’Archivio Centrale di Stato, l’autore si propone di contribuire alla formazione di un paradigma capace di delineare le peculiarità di questa figura professionale. Lo scopo della ricerca è quello di concorrere alla ricostruzione di un modello storico del docente italiano di ginnastica, attraverso una prospettiva comparativa con le esperienze coeve sviluppatesi negli altri Stati – Francia, Spagna e Portogallo – inclusi nell’area latina.

This contribution, starting from the definition of a typical sports model for the «Latin» European area, intends to reflect on the figure of the gymnastics teacher in Italy in the Liberal Age. By reading the statistical data concerning the teachers of this discipline in service in the school year 1885/1886, kept in the Central State Archives, the author intends to contribute to the formation of a paradigm capable of delineating the peculiarities of this professional. Furthermore, the research aims to reconstruct a historical model of the Italian gymnastic teacher through a comparative perspective with the contemporary experiences developed in the other states – France, Spain, and Portugal – included in the Latin area.
description: Gli Argonauti. Rivista di Studi Storico-Educativi e Pedagogici, V. 4, N. 1 (2024)
Gravity of a noncanonical global monopole: conical topology and compactification
Creators: name: Prasetyo, Ilham
name: Ramadhan, Handhika S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We obtain solutions of Einstein's equations describing gravitational field outside a noncanonical global monopole with cosmological constant. In particular, we consider two models of k-monopoles: the Dirac-Born-Infeld (DBI) and the power-law types, and study their corresponding exterior gravitational fields. For each model we found two types of solutions. The first of which are global k-monopole black hole with conical global topology. These are generalizations of the Barriola-Vilenkin solution of global monopole. The appearance of noncanonical kinetic terms does not modify the critical symmetry-breaking scale, $η_{crit}$, but it does affect the corresponding horizon(s). The second type of solution is compactification, whose topology is a product of two $2$-dimensional spaces with constant curvatures; ${\mathcal Y}_4\rightarrow {\mathcal Z}_2\times S^2$, with ${\mathcal Y}, {\mathcal Z}$ can be de Sitter, Minkowski, or Anti-de Sitter, and $S^2$ is the $2$-sphere. We investigate all possible compactifications and show that the nonlinearity of kinetic terms opens up new channels which are otherwise non-existent. For $Λ=0$ four-dimensional geometry, we conjecture that these compactification channels are their (possible) non-static super-critical states, right before they undergo topological inflation.
description: Erratum added
Spectroscopy of ground and excited states of pseudoscalar and vector charmonium and bottomonium
Creators: name: Negash, Hluf
name: Bhatnagar, Shashank
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this work we calculate the mass spectrum, weak decay constants, two photon decay widths, and two gluon decay widths of ground (1S), and radially excited (2S,3S,...) states of pseudoscalar charmoniuum and bottomonium such as $η_{c}$ and $η_{b}$, as well as the mass spectrum and leptonic decay constants of ground state (1S), excited (2S,1D,3S,2D,4S,and 3D) states of vector charmonium and bottomonium such as $J/ψ$, and $Υ$, using the formulation of Bethe-Salpeter equation under covariant Instantaneous Ansatz (CIA). Our results are in good agreement with data (where ever available) and other models. In this framework, from the beginning, we employ a $4\times 4$ representation for two-body ($q\overline{q}$) BS amplitude for calculating both the mass spectra as well as the transition amplitudes. However, the price we have to pay is to solve a coupled set of equations for both pseudoscalar and vector quarkonia, which we have explicitly shown get decoupled in the heavy-quark approximation, leading to mass spectral equation with analytical solutions for both masses, as well as eigenfunctions for all the above states, in an approximate harmonic oscillator basis. Further, in the present framework of BSE, the hadron-quark vertex function (and the full 4D BS wave function) for pseudoscalar and vector quarkonia used for calculation of various processes, accommodates all the Dirac structures from their complete set in a natural manner.
description: 33 pages, 5 figure, 6 tables
A Markov Decision Process Approach to Control of Networks and Analysis of North Carolina COVID-19 Spread by a New Compartmental Model
Creators: name: Whitehead, Thomas
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Networks play an important role in modelling the interactions of people, and how this can lead to the spread
of ideas, influence, products, and disease. For my first semester of research, I focus on modelling social
networks as Finite Horizon Markov Decision Processes, so that I can find the optimal set of activations using
Backwards Iteration. In particular, I focus on Linear Threshold social networks and Independent Cascade
social networks. For the second semester of research, I focus on working with a compartmental model created
by Housni et al., to model the spread of Covid-19 in North Carolina [3]. I make three major adjustments to
the model: including a parameter that accounts for the possibility of False Negative tests, and eliminating
the effects of contact tracing. The former adjustment does not result in any significant changes in outcome,
while the latter results in a highly unrealistic predictions.
New constraints on primordial gravitational waves from Planck 2015
Creators: name: Pagano, Luca
name: Salvati, Laura
name: Melchiorri, Alessandro
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We show that the new precise measurements of Cosmic Microwave Background (CMB) temperature and polarization anisotropies made by the Planck satellite significantly improves previous constraints on the cosmic gravitational waves background (CGWB) at frequencies $f>10^{-15}$ Hz. On scales smaller than the horizon at the time of decoupling, primordial gravitational waves contribute to the total radiation content of the Universe. Considering adiabatic perturbations, CGWB affects temperature and polarization CMB power spectra and matter power spectrum in a manner identical to relativistic particles. Considering the latest Planck results we constrain the CGWB energy density to $Ω_{\rm gw} h^2 <1.7\times 10^{-6} $ at 95\% CL. Combining CMB power spectra with lensing, BAO and primordial Deuterium abundance observations, we obtain $Ω_{\rm gw} h^2 <1.2\times 10^{-6} $ at 95\% CL, improving previous Planck bounds by a factor 3 and the recent direct upper limit from the LIGO and VIRGO experiments a factor 2. A combined analysis of future satellite missions as COrE and EUCLID could improve current bound by more than an order of magnitude.
description: 9 pages, 1 figure, matching the version published on PLB
Public Comment at the COVID vaccine FDA Advisory Committee Meeting February 26, 2021
Creators: name: Lazard, Allison
name: Brownstein, John S.
name: Dasgupta, Nabarun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021
Subjects: Vaccines
Drugs--Side effects
COVID-19 (Disease)

description: Public comments on COVID-19 vaccine side effect surveillance at the US Food and Drug Administration (FDA) Advisory Committee on February 26, 2021. The Janssen (Johnson & Johnson) vaccine was discussed at this meeting.

We declare no conflicts of interest.
Learning Common Harmonic Waves on Stiefel Manifold - A New Mathematical Approach for Brain Network Analyses
Creators: name: Laurienti, P.J.
name: Chen, J.
name: Styner, M.
name: Han, G.
name: Cai, H.
name: Wu, G.
name: Yang, D.
Publisher: name: Institute of Electrical and Electronics Engineers Inc.
Year: 2021

description: Converging evidence shows that disease-relevant brain alterations do not appear in random brain locations, instead, their spatial patterns follow large-scale brain networks. In this context, a powerful network analysis approach with a mathematical foundation is indispensable to understand the mechanisms of neuropathological events as they spread through the brain. Indeed, the topology of each brain network is governed by its native harmonic waves, which are a set of orthogonal bases derived from the Eigen-system of the underlying Laplacian matrix. To that end, we propose a novel connectome harmonic analysis framework that provides enhanced mathematical insights by detecting frequency-based alterations relevant to brain disorders. The backbone of our framework is a novel manifold algebra appropriate for inference across harmonic waves. This algebra overcomes the limitations of using classic Euclidean operations on irregular data structures. The individual harmonic differences are measured by a set of common harmonic waves learned from a population of individual Eigen-systems, where each native Eigen-system is regarded as a sample drawn from the Stiefel manifold. Specifically, a manifold optimization scheme is tailored to find the common harmonic waves, which reside at the center of the Stiefel manifold. To that end, the common harmonic waves constitute a new set of neurobiological bases to understand disease progression. Each harmonic wave exhibits a unique propagation pattern of neuropathological burden spreading across brain networks. The statistical power of our novel connectome harmonic analysis approach is evaluated by identifying frequency-based alterations relevant to Alzheimer's disease, where our learning-based manifold approach discovers more significant and reproducible network dysfunction patterns than Euclidean methods.
Profile of Brazilian climacteric women: results from the Brazilian Menopause Study
Creators: name: Pompei, L. M.
name: Bonassi-Machado, R.
name: Steiner, M. L.
name: Pompei, I. M.
name: de Melo, N. R.
name: Nappi, R. E.
name: Fernandes, C. E.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: This study aims to understand the epidemiological characteristics of Brazilian menopausal women, and their view on menopause hormone therapy (MHT). A national cross-sectional study with 1500 women between 45 and 65 years old was carried out through questionnaires. The overall median age of participants was 52 [47–56] years, and 55 [52–59] years for the postmenopausal subgroup. Menstrual irregularity started at median age 46 [44–49] years. Median menopause age was 48 [45–51] years with no differences between socioeconomic classes. The prevalence of any climacteric symptoms was 87.9% and hot flashes started at median age 47 [45–50] years. Among women in menopause/menopausal transition, 52.1% received any medical prescription, and MHT was recommended for 22.3%. Among those who started MHT, 45.4% were still using the treatment and the median duration of use was 8 months, but different among socioeconomic classes (24 months for class A against 3 months for class D/E). In this first Brazilian national population-based study on menopause and MHT, it was observed that, in spite of being symptomatic when entering menopause around 48 years of age, only a small part of Brazilian women started MHT and the median duration of treatment was less than 1 year, but the duration was higher for higher socioeconomic class.
A voxel-wise assessment of growth differences in infants developing autism spectrum disorder
Creators: name: Fonov, V.S.
name: Gerig, G.
name: Dager, S.R.
name: Lewis, J.D.
name: Pruett, J.R., Jr.
name: McKinstry, R.C.
name: Collins, D.L.
name: Piven, J.
name: Cárdenas-de-la-Parra, A.
name: Elison, J.T.
name: IBIS Network
name: Styner, M.A.
name: Evans, A.C.
name: Botteron, K.N.
Publisher: name: Elsevier Inc.
Year: 2021

description: Autism Spectrum Disorder (ASD) is a phenotypically and etiologically heterogeneous developmental disorder typically diagnosed around 4 years of age. The development of biomarkers to help in earlier, presymptomatic diagnosis could facilitate earlier identification and therefore earlier intervention and may lead to better outcomes, as well as providing information to help better understand the underlying mechanisms of ASD. In this study, magnetic resonance imaging (MRI) scans of infants at high familial risk, from the Infant Brain Imaging Study (IBIS), at 6, 12 and 24 months of age were included in a morphological analysis, fitting a mixed-effects model to Tensor Based Morphometry (TBM) results to obtain voxel-wise growth trajectories. Subjects were grouped by familial risk and clinical diagnosis at 2 years of age. Several regions, including the posterior cingulate gyrus, the cingulum, the fusiform gyrus, and the precentral gyrus, showed a significant effect for the interaction of group and age associated with ASD, either as an increased or a decreased growth rate of the cerebrum. In general, our results showed increased growth rate within white matter with decreased growth rate found mostly in grey matter. Overall, the regions showing increased growth rate were larger and more numerous than those with decreased growth rate. These results detail, at the voxel level, differences in brain growth trajectories in ASD during the first years of life, previously reported in terms of overall brain volume and surface area.
Cortical Structure and Cognition in Infants and Toddlers
Creators: name: Girault, J.B.
name: Jha, S.C.
name: Knickmeyer, R.C.
name: Murphy, V.A.
name: Cornea, E.
name: Shen, D.
name: Styner, M.
name: Li, G.
name: Wang, L.
name: Goldman, B.D.
name: Gilmore, J.H.
Publisher: name: Oxford University Press
Year: 2020

description: Cortical structure has been consistently related to cognitive abilities in children and adults, yet we know little about how the cortex develops to support emergent cognition in infancy and toddlerhood when cortical thickness (CT) and surface area (SA) are maturing rapidly. In this report, we assessed how regional and global measures of CT and SA in a sample (N = 487) of healthy neonates, 1-year-olds, and 2-year-olds related to motor, language, visual reception, and general cognitive ability. We report novel findings that thicker cortices at ages 1 and 2 and larger SA at birth, age 1, and age 2 confer a cognitive advantage in infancy and toddlerhood. While several expected brain-cognition relationships were observed, overlapping cortical regions were also implicated across cognitive domains, suggesting that infancy marks a period of plasticity and refinement in cortical structure to support burgeoning motor, language, and cognitive abilities. CT may be a particularly important morphological indicator of ability, but its impact on cognition is relatively weak when compared with gestational age and maternal education. Findings suggest that prenatal and early postnatal cortical developments are important for cognition in infants and toddlers but should be considered in relation to other child and demographic factors.
Constraining the shape of Milky Way satellites with distance gradients
Creators: name: An, Zhaozhou
name: Koposov, Sergey E.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We combine the Dark Energy Camera Legacy Survey (DECaLS) DR8 photometry with Gaia photometry to study the 3-D structure of Bootes I, Draco, Ursa Minor, Sextans and Sculptor dwarf galaxies using blue horizontal branch (BHB) stars as distance indicators. We construct a new colour-absolute magnitude of BHB stars that we use to measure the distance gradients within the body of the dwarf galaxies. We detect a statistically significant non-zero gradient only in Sextans and Sculptor. Through modeling of the gradient and 2-D density of the systems by triaxial Plummer models we find that the distance gradients in both dwarf galaxies are inconsistent with prolate shape, but compatible with oblate or triaxial shapes. In order to explain the observed gradients, oblate models of Sextans and Sculptor need to have a significant intrinsic ellipticity larger than $0.47$ for Sextans and $0.46$ for Sculptor. The flattened oblate shape may imply a significant anisotropy in velocity distribution in order to be consistent with the lack of significant velocity gradients in these systems.
description: 21 pages, 7 figures
Altered Brain Structure in Infants with Turner Syndrome
Creators: name: Gilmore, J.H.
name: Hooper, S.R.
name: Davenport, M.L.
name: Pretzel, R.
name: Styner, M.
name: Xia, K.
name: Reinhartsen, D.
name: Deramus, M.
name: Cornea, E.
name: Knickmeyer, R.C.
name: Halvorsen, M.W.
name: Crowley, J.J.
name: Goldman, B.D.
Publisher: name: Oxford University Press
Year: 2020

description: Turner syndrome (TS) is a genetic disorder affecting approximately 1:2000 live-born females. It results from partial or complete X monosomy and is associated with a range of clinical issues including a unique cognitive profile and increased risk for certain behavioral problems. Structural neuroimaging studies in adolescents, adults, and older children with TS have revealed altered neuroanatomy but are unable to identify when in development differences arise. In addition, older children and adults have often been exposed to years of growth hormone and/or exogenous estrogen therapy with potential implications for neurodevelopment. The study presented here is the first to test whether brain structure is altered in infants with TS. Twenty-six infants with TS received high-resolution structural MRI scans of the brain at 1 year of age and were compared to 47 typically developing female and 39 typically developing male infants. Results indicate that the typical neuroanatomical profile seen in older individuals with TS, characterized by decreased gray matter volumes in premotor, somatosensory, and parietal-occipital cortex, is already present at 1 year of age, suggesting a stable phenotype with origins in the prenatal or early postnatal period.
IN PARTIAL FULFILLMENT OF REQUIREMENTS FOR MASTERS DEGREE IN BUSINESS ADMINISTRATION
Creators: name: MOHAMMED KASSIE ABEBE
Publisher: name: Zenodo
Year: 2011

description: The purpose of this paper is to examine the contribution and effect of BPR factors on employee performance. Egalitarian leadership, cooperative working environment, top management commitment, management system, information technology and resistance to change are major factors dealt in the process. The first five factors are catalysts for positive employee performance whereas the sixth factor is affecting employee performance negatively. Capacity building and land administration bureaus are representing Addis Ababa City Administration. Twenty five percent of employees and two managers are considered for investigation. The researcher used questionnaire, interview, secondary documents and observation. These methods are used to collect data related with BPR factors and employee performance. Data presentation, analysis and interpretation are made with the aid of regression and descriptive statistics. Moreover, qualitative data is analysed thematically. All, but top management commitment, have had positive impact on employee performance. In terms of contribution, cooperative-working environment is followed by managements system, resistance to change, egalitarian leadership, and information system. Findings, of top management commitment and resistance to change, show contradictory views against the theory advocated by the diamond model.
title: Neither Here Nor There: An Investigation Into The Role Of The Photographer’s Subjective View in Landscape Photography.
Creators: name: Stenhouse, Adam
Publisher: name: Emily Carr University of Art and Design
Year: 2012
Subjects: subject: Landscape photography
valueUri: https://id.loc.gov/authorities/subjects/sh85101229
subject: Criticism
valueUri: https://id.loc.gov/authorities/subjects/sh85034149
subject: Landscapes in art
valueUri: https://id.loc.gov/authorities/subjects/sh85074423
subject: Creation (Literary, artistic, etc.)
valueUri: https://id.loc.gov/authorities/subjects/sh85033827

description: This thesis will examine the role of a landscape photographer’s subjective view in the construction of a photographic image by considering the significance of their photographic intent, visual relationship to the physical world and personal relationship to place. I will deconstruct my series Neither Here Nor There, examining the significance of investing my own history of experience and memory into the photograph in order to explore my relationship to the landscapes I have lived in. The paper will examine the roles of the photographer and the viewer when reading a photograph, using Susan Sontag’s ideas of authority within the photograph from On Photography, Roland Barthes’ concept of the ‘punctum’ from Camera Lucida, and Robert Adams’ essay Truth and Landscape, to investigate how a photographer forms intent within his photographs. Drawing on Kaja Silverman’s World Spectators, the paper will go on to explore an individual’s visual relationship with the physical world whilst maintaining the core idea of exploring the photographer’s intentionality within a photograph by using the practice of Thomas Joshua Cooper as an example of a photographer who claims authority over his images. The thesis then analyses how concepts of place influence this conversation by using Yi Fu Tuan’s Space and Place to investigate an individual’s relationship with the physical world. Taking Italo Calvino’s Mr Palomar and Rinko Kawauchi’s photographic series The Eyes, The Ears as examples, the paper looks at the representation of an individual’s relationship to the physical world through their internal solipsistic view. The essay concludes with an explanation of how my photographic series Neither Here Nor There, tackles the issue of the representation of the photographer’s intent and subjectivevision, by offering an autobiographical reaction to my own sense of place.
Plasma homocysteine levels and handgrip strength in postmenopausal women
Creators: name: García-Alfaro, P.
name: Rodriguez, I.
name: Pérez-López, F. R.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: This study evaluated handgrip strength (HGS), circulating homocysteine levels and related factors in postmenopausal women. This study is a sub-analysis of a prospective cohort of 303 postmenopausal women aged 62.7 ± 6.9 years who had HGS measures with a digital dynamometer as the primary outcome, and plasma homocysteine and creatinine levels and glomerular filtration rate (GFR) measures as the secondary outcomes. The average HGS was 22.5 ± 4.0 kg, 29.4% of women had dynapenia (HGS < 20 kg), adiposity was 40.3 ± 5.4% and 9.57% of women had hyperhomocysteinemia (homocysteine >15 μmol/l). There were no differences between tertiles of homocysteine and HGS (p = 0.641). Plasma homocysteine levels were unrelated to HGS (r = −0.06) and correlated with age (r = 0.17), GFR (r = −0.28) and creatinine (r = 0.23). Hyperhomocysteinemia was not associated with HGS (odds ratio [OR] = 0.98 [95% confidence interval (CI): 0.89; 1.08]) or dynapenia (OR = 1.10 [95% CI: 0.45; 2.47]). The risk of presenting low HGS were not significantly associated with homocysteine (OR = −0.08 [95% CI: −0.21; 0.06]) and were associated with age (OR = −0.23 [95% CI: −0.29; −0.17]), adiposity (OR = −6.52 [95% CI: −9.53; −3.50]) and creatinine (OR = 6.22 [95% CI: 2.48; 9.97]). HGS and dynapenia were unrelated to hyperhomocysteinemia. Age, GFR and creatinine were significantly associated with plasma homocysteine levels.
Pilot study of women’s perspectives when abnormal uterine bleeding occurs during perimenopause
Creators: name: DeStephano, C. C.
name: Allyse, M. A.
name: Abu Dabrh, A. M.
name: Ridgeway, J. L.
name: Salinas, M.
name: Sherman, M. E.
name: Spaulding, A. C.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: We gained insights into women’s experiences and knowledge about the occurrence of vaginal bleeding during perimenopause requiring evaluation. Qualitative inquiry was chosen to explore topics in greater depth to understand individuals’ experiences. Interviews with individuals were chosen due to the sensitive nature of gynecologic symptoms and management. Interviews were completed following gynecologic care to explore individuals’ experiences with the evaluation and management of vaginal bleeding during perimenopause. Twelve individuals were interviewed between December 2019 and March 2020. Patient uncertainty about the medical significance of developing vaginal bleeding during perimenopause was associated with self-appraisal and gathering information from multiple sources. This experience of seeking evaluation and treatment resulted in varying degrees of trust concerning information received within or outside the clinic. Regarding new technologies that could replace the current invasive tests performed for diagnosis (i.e. ultrasound, hysteroscopy and biopsy), most women preferred the smartphone app and tampon home collection option. The experience of irregular or heavy vaginal bleeding during perimenopause is fraught with ambiguity, feelings of uncertainty about how to make sense of symptoms and inevitably begins with a period of self-appraisal.
title: A Different Way of Remembering? Cultural Memory, Continuity, and Change in the First World War Centenary
Creators: name: Power, Helena Frances Steuck
Publisher: name: University of Kent
Year: 2025

description: This thesis explores how cultural memory of the First World War in Britain has changed in the digital age, and which elements have remained the same. Through a consideration of television programmes, websites, and social media posts, it reveals that longstanding aspects of cultural memory, primarily senses of futility and loss established in the 1960s, have remained entrenched in popular ideas about the conflict, and are now utilised in discussions about the war and its representations across the Internet. The number of people involved in discussions about the past is now greater than ever before, yet the online realm tends to exist as an echo chamber for popular ideas, rather than a debate ground for forming new ones.

On television, representations of the war have remained largely consistent with pre-Centenary tropes. Some of the most novel developments during the Centenary included an increased focus on 'forgotten' histories, and programming aimed at the younger generations. The BBC in particular often found itself commemorating its own programming history almost as much as the war itself, a habit which tended to foreground familiar veteran testimony and wartime footage over revealing new insights into the conflict. Attempts to break this mould, such as programmes targeted at young people using visual techniques more often associated with video games, were met with some criticism for breaking with 'authentic' visions of the war. Yet, they are all evidence of moves away from old ideas.

Online, websites have been viewed as creating a web of memory, with intersecting viewpoints evident across different platforms. While some websites are evident reservoirs of ongoing information beyond the Centenary, others have disappeared into digital oblivion. Thus, contemporary cultural memory is both a fluctuating and ephemeral phenomenon.
Isolated compact elliptical galaxies: Stellar systems that ran away
Creators: name: Chilingarian, Igor
name: Zolotukhin, Ivan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Compact elliptical galaxies form a rare class of stellar system (~30 presently known) characterized by high stellar densities and small sizes and often harboring metal-rich stars. They were thought to form through tidal stripping of massive progenitors, until two isolated objects were discovered where massive galaxies performing the stripping could not be identified. By mining astronomical survey data, we have now found 195 compact elliptical galaxies in all types of environment. They all share similar dynamical and stellar population properties. Dynamical analysis for nonisolated galaxies demonstrates the feasibility of their ejection from host clusters and groups by three-body encounters, which is in agreement with numerical simulations. Hence, isolated compact elliptical and isolated quiescent dwarf galaxies are tidally stripped systems that ran away from their hosts.
description: Published in Science, 8 pages, 7 figures, 1 table including the supplementary information section; MS Excel table with the list of galaxies is available here http://www.sciencemag.org/content/suppl/2015/04/22/348.6233.418.DC1/aaa3344_Chilingarian_TableS1.xlsx
Signals of Geophysical Nature in GRACE and GRACE-FO Post-Fit Range-Rate Residuals
Creators: name: Koch, Igor
name: Duwe, Mathias
name: Flury, Jakob
name: Fletling, Nina
Publisher: name: Hannover : Institutionelles Repositorium der Leibniz Universität Hannover
Year: 2023
Subjects: subject: GRACE
subject: GRACE-FO
subject: Gravity field recovery
subject: K-band residuals
subject: Tides
subject: Schwerefeldbestimmung
subject: K-Band Residuen
subject: Gezeiten
subject: Dewey Decimal Classification::600 | Technik

description: Post-fit residuals of satellite-to-satellite tracking measurements of the GRACE and GRACE-FO missions obtained after a common estimation of orbit and gravity field parameters should ideally contain measurement noise with a behavior that meets expectations for the involved sensors. In reality, obtained GRACE and GRACE-FO post-fit range-rate residuals represent a complex superposition of different effects, e.g. of instrumental, environmental and geophysical nature. In this contribution, we focus on the geophysical signals in the post-fit residuals of the LUH GRACE and GRACE-FO time series. We apply band-pass filtering to extract the geophysical signal buried in the residuals and analyze the most distinctive signatures for their spatial and temporal behavior.
Longitudinal change in autonomic symptoms predicts activities of daily living and depression in Parkinson’s disease
Creators: name: Styner, M.
name: Dayan, E.
name: Shih, C.-H.
name: Sklerov, M.
name: Palma, J.-A.
name: Browner, N.
Publisher: name: Springer
Year: 2020

description: Purpose: The primary objective of this study was to examine the relationship of longitudinal changes in autonomic symptom burden and longitudinal changes in activities of daily living (ADLs); a secondary analysis examined the impact of depressive symptoms in this relationship. Methods: Data were retrieved from the Parkinson’s Progression Markers Initiative (PPMI), a dataset documenting the natural history of newly diagnosed Parkinson’s disease (PD). The analysis focused on data from baseline, visit 6 (24 months after enrollment), and visit 12 (60 months after enrollment). The impact of longitudinal changes in autonomic symptom burden on longitudinal changes in ADLs function was examined. A secondary mediation analysis was performed to investigate whether longitudinal changes in depressive symptoms mediate the relationship between longitudinal changes in autonomic symptom burden and ADLs function. Results: Changes in autonomic symptom burden, cognitive function, depressive symptoms, and motor function all correlated with ADLs. Only changes in ADLs and depression were found to be associated with changes in autonomic symptom burden. We found that longitudinal change in autonomic symptoms was a significant predictor of change in ADLs at 24 and 60 months after enrollment, with the cardiovascular subscore being a major driver of this association. Mediation analysis revealed that the association between autonomic symptoms and ADLs is partially mediated by depressive symptoms. Conclusions: Longitudinal changes in autonomic symptoms impact ADLs function in patients with early signs of PD, both directly and indirectly through their impact on depressive symptoms. Future investigation into the influence of treatment of these symptoms on outcomes in PD is warranted.
Neonatal brain volume as a marker of differential susceptibility to parenting quality and its association with neurodevelopment across early childhood
Creators: name: Rasmussen, J.M.
name: Nolvi, S.
name: Gilmore, J.H.
name: Wadhwa, P.D.
name: Fair, D.A.
name: Buss, C.
name: Entringer, S.
name:  Styner, M.
name: Graham, A.M.
Publisher: name: Elsevier Ltd
Year: 2020

description: Parenting quality is associated with child cognitive and executive functions (EF), which are important predictors of social and academic development. However, children vary in their susceptibility to parenting behaviors, and the neurobiological underpinnings of this susceptibility are poorly understood. In a prospective longitudinal study, we examined whether neonatal total brain volume (TBV) and subregions of interest (i.e., hippocampus (HC) and anterior cingulate gyrus (ACG)) moderate the association between maternal sensitivity and cognitive/EF development across early childhood. Neonates underwent a brain magnetic resonance imaging scan. Their cognitive performance and EF was characterized at 2.0 ± 0.1 years (N = 53) and at 4.9 ± 0.8 years (N = 36) of age. Maternal sensitivity was coded based on observation of a standardized play situation at 6-mo postpartum. Neonatal TBV moderated the association between maternal sensitivity and 2-year working memory as well as all 5-year cognitive outcomes, suggesting that the positive association between maternal sensitivity and child cognition was observed only among children with large or average but not small TBV as neonates. Similar patterns were observed for TBV-corrected HC and ACG volumes. The findings suggest that larger neonatal TBV, HC and ACG may underlie susceptibility to the environment and affect the degree to which parenting quality shapes long-term cognitive development.
ผลของกิจกรรมจิตศึกษาที่มีต่อการเข้าใจความรู้สึกผู้อื่นของเด็กปฐมวัย
Creators: name: ปิยะนุช ซอดนอก
Publisher: name: ภาควิชาวิจัยและจิตวิทยาการศึกษา คณะครุศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย
Year: 2566
Subjects: กิจกรรมจิตศึกษา
การเข้าใจความรู้สึกผู้อื่น
Jittasuksa Activities
Empathy

description: วารสารวิธีวิทยาการวิจัย (Journal of Research Methodology: JRM), 36, 1, 18-30
Excitable-like chaotic pulses in the bounded-phase regime of an opto-radiofrequency oscillator
Creators: name: Romanelli, Marco
name: Thorette, Aurélien
name: Brunel, Marc
name: Erneux, Thomas
name: Vallet, Marc
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We report theoretical and experimental evidence of chaotic pulses with excitable-like properties in an opto-radiofrequency oscillator based on a self-injected dual-frequency laser. The chaotic attractor involved in the dynamics produces pulses that, albeit chaotic, are quite regular: They all have similar amplitudes, and are almost periodic in time. Thanks to these features, the system displays properties that are similar to those of excitable systems. In particular, the pulses exhibit a threshold-like response, of well-defined amplitude, to perturbations, and it appears possible to define a refractory time. At variance with excitability in injected lasers, here the excitable-like pulses are not accompanied by phase slips.
description: 2nd version
Three discussions of the paper "sequential quasi-Monte Carlo sampling", by M. Gerber and N. Chopin
Creators: name: Arbel, Julyan
name: Prunster, Igor
name: Robert, Christian P.
name: Ryder, Robin J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computation (stat.CO)
subject: FOS: Computer and information sciences

description: This is a collection of three written discussions of the paper "sequential quasi-Monte Carlo sampling" by M. Gerber and N. Chopin, following the presentation given before the Royal Statistical Society in London on December 10th, 2014.
description: Published in the Journal of the Royal Statistical Society, volume 77(3), pages 559, 569 and 570
On the occurrence of galaxy harassment
Creators: name: Bialas, Daniel
name: Lisker, Thorsten
name: Olczak, Christoph
name: Spurzem, Rainer
name: Kotulla, Ralf
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Tidal interactions of galaxies in galaxy clusters have been proposed as one potential explanation of the morphology-density relation at low masses. The efficiency of tidal transformation is expected to depend strongly on the orbit of a galaxy within the cluster halo. The orbit determines both the strength of the cluster's global tidal field and the probability of encounters with other cluster members. Additionally, we investigate the effect of an inclination between the disk of the infalling galaxy and its orbital plane. We also compare our results to observational data. We find that galaxies that entered a cluster from the outskirts are unlikely to be significantly transformed. Closer to the cluster centre, tidal interactions are a more efficient mechanism for producing harassed galaxies. But the inclination of the disk can reduce the mass loss significantly, yet it amplifies the thickening.
description: Accepted by A&A, 15 pages
МЕТОДИКА СОСТАВЛЕНИЯ ЛЕДОВЫХ КАРТ ААНИИ
Creators: name: Е. В. Афанасьева
name: Т. А. Алексеева
name: Ю. В. Соколова
name: Д. М. Демчев
name: М. С. Чуфарова
name: Ю. Д. Быченков
name: О. С. Девятаев
Publisher: name: Российская Арктика
Year: 2019
Subjects: Арктика
дешифрирование морского льда
морской лед
сплоченность
возраст морского льда
ледовая карта
ААНИИ
ледовый эксперт
ледовая служба.

description: Ледовые карты Арктического и антарктического научно-исследовательского института (ААНИИ) широко используются для ряда научных и практических задач, однако до сих пор не была опубликована подробная и обобщенная информация о методах их составления. В данной статье сотрудниками центра «Север» ААНИИ, непосредственно занимающимися составлением ледовых карт в настоящее время, описаны особенности методики и используемые для картирования данные. Представленный в статье обзор полезен для корректного применения ледовых карт пользователями для своих научных и практических задач.
Neonatal hippocampal volume moderates the effects of early postnatal enrichment on cognitive development
Creators: name: Wadhwa, P.D.
name: Overfeld, J.
name: Entringer, S.
name: Styner, M.A.
name: Gilmore, J.H.
name: Buss, C.
name: Rasmussen, J.M.
name: Heim, C.M.
Publisher: name: Elsevier Ltd
Year: 2020

description: Environmental enrichment, particularly during the early life phases of enhanced neuroplasticity, can stimulate cognitive development. However, individuals exhibit considerable variation in their response to environmental enrichment. Recent evidence suggests that certain neurophenotypes such as hippocampal size may index inter-individual differences in sensitivity to environmental conditions. We conducted a prospective, longitudinal investigation in a cohort of 75 mother-child dyads to investigate whether neonatal hippocampal volume moderates the effects of the postnatal environment on cognitive development. Newborn hippocampal volume was quantified shortly after birth (26.2 ± 12.5 days) by structural MRI. Measures of infant environmental enrichment (assessed by the IT-HOME) and cognitive state (assessed by the Bayley-III) were obtained at 6 months of age (6.09 ± 1.43 months). The interaction between neonatal hippocampal volume and enrichment predicted infant cognitive development (b = 0.01, 95 % CI [0.00, 0.02], t = 2.08, p =.04), suggesting that exposure to a stimulating environment had a larger beneficial effect on cognitive outcomes among infants with a larger hippocampus as neonates. Our findings suggest that the effects of the postnatal environment on infant cognitive development are conditioned, in part, upon characteristics of the newborn brain, and that newborn hippocampal volume is a candidate neurophenotype in this context.
Association of menopausal status and symptoms with depressive symptoms in middle-aged Chinese women
Creators: name: Wang, X. Y.
name: Wang, L. H.
name: Di, J. L.
name: Zhang, X. S.
name: Zhao, G. L.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: This study aims to examine the association of menopausal status and symptoms with depressive symptoms. A community-based cross-sectional survey recruited 6745 women aged 40–55 years in the eastern, central and western regions of China in 2018. Menopausal status was categorized into reproductive stage, perimenopause or postmenopause according to the Stages of Reproductive Aging Workshop classification. Menopausal symptoms were determined by the modified Kupperman Menopausal Index and classified as none (total score < 15), mild (15 ≤ total score ≤ 24) or moderate to severe (total score ≥ 25). Logistic regression models were used to examine the associations of menopausal status and symptoms with depressive symptoms assessed by the Patient Health Questionnaire-9. The prevalence of depressive symptoms among women in the reproductive stage, perimenopause and postmenopause was 15.4%, 23.9% and 22.8%, respectively. After multivariable adjustment, perimenopause (odds ratio [OR] = 1.21, 95% confidence interval [CI]: 1.01–1.47) and postmenopause (OR = 1.28, 95% CI: 1.04–1.58) were associated with higher risk for depressive symptoms than during the reproductive stage. Mild (OR = 5.55, 95% CI: 4.68–6.59) and moderate-to-severe (OR = 14.77, 95% CI: 10.94–19.94) menopausal symptoms were associated with increased likelihood of depressive symptoms compared to the group reporting no menopausal symptoms. Menopausal status and symptoms were independently associated with the risk of depressive symptoms in middle-aged Chinese women.
ПРИМЕНЕНИЕ ГИДРОЛОКАЦИОННОГО КОМПЛЕКСА ПРИ ОБСЛЕДОВАНИИ НИЖНЕЙ ПОВЕРХНОСТИ ЛЬДА
Creators: name: С. В. Хотченков
name: Ю. Г. Гаврилов
name: М. Ю. Наумов
Publisher: name: Российская Арктика
Year: 2019
Subjects: морфометрические параметры льда
гидролокационные исследования
подводная съёмка
гидролокатор
торосы
айсберги

description: В статье рассматриваются методические вопросы применения гидролокационного метода определения формы нижней поверхности льда, непосредственно с поверхности льда в условиях Арктики, как комплексного решения при морфометрических исследованиях. Приведены результаты опытного использования гидролокационного метода на примере измерений в море Лаптевых.