title: ÐÐµÐ»ÐºÐ¸ TIMP-1, IL-8, ÑÐµÑÐµÐ¿ÑÐ¾ÑÑ Ðº Ð¼ÐµÐ»Ð°ÑÐ¾Ð½Ð¸Ð½Ñ a Ð¸ b Ð¿ÑÐ¸ Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ð°ÑÐ¾Ð·Ð½Ð¾Ð¼ Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ð¸ Ð² ÑÐºÐ°Ð½Ð¸ Ð»ÑÐ³ÐºÐ¾Ð³Ð¾ - Ð¸Ð¼Ð¼ÑÐ½Ð¾ÑÐ½Ð´Ð¾ÐºÑÐ¸Ð½Ð½ÑÐµ Ð°ÑÐ¿ÐµÐºÑÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Proteins TIMP-1, IL-8, receptors to melatonin a and b for granulematosis inflammation in lung tissue - immunoendokrin aspects
Creators: name: ÐÐµÐ¾Ð½ÑÑÐµÐ²Ð°, ÐÐ°ÑÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ð°ÑÐ¾Ð·Ð½Ð¾Ðµ Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ðµ
ÑÐ°ÑÐºÐ¾Ð¸Ð´Ð¾Ð·
ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·
Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÐµ Ð¼Ð°ÑÐºÐµÑÑ
Ð¸Ð½ÑÐµÑÐ»ÐµÐ¹ÐºÐ¸Ð½-8
ÑÐºÐ°Ð½ÐµÐ²ÑÐ¹ Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÐ¾Ñ Ð¼Ð°ÑÐ°Ð»Ð»Ð¾Ð¿ÑÐ¾ÑÐµÐ¸Ð½Ð°Ð·-1
Ð¼ÐµÐ»Ð°ÑÐ¾Ð½Ð¸Ð½
ÑÐµÑÐµÐ¿ÑÐ¾ÑÑ Ðº Ð¼ÐµÐ»Ð°ÑÐ¾Ð½Ð¸Ð½Ñ
Ð¸Ð¼Ð¼ÑÐ½Ð¾Ð³Ð¸ÑÑÐ¾Ñ Ð¸Ð¼Ð¸Ñ
granulematosis inflammation
sarcoidosis
tuberculosis
molecular markers
interleukin-8
tissue inhibitor matalloproteinase-1
melatonin
melatonin receptors
immunohistochemistry

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description: In the present work, the study of the expression of molecular markers involved in the formation and resolution of granulomas in lung tissue samples was evaluated. Interleukin-8 proteins and a tissue inhibitor of metalloproteinases-1 were verified tostudy immune signaling molecules; membrane receptors MT-1 (melatonin receptor 1A) and MT-2 (melatonin receptor 1B) were verified to study endocrine signaling molecules. The experimental group consisted of 12 patients (9 women and 3 men, average age 33 years). In these patients, epithelioid cell granulomas with giant multinuclear Langhans cells were observed in histological examination of lung tissue. As a result of the experiment, results were obtained that are consistent with the literature data, the expression levels of the studied markers may previously correlate with various stages of granulomatous inflammation.