cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Burden and Preparedness amongst Informal Caregivers of Adults with Moderate to Severe Traumatic Brain Injury
Creators: name: Lieshout, Kirsten
name: Oates, Joanne
name: Baker, Anne
name: Unsworth, Carolyn A.
name: Cameron, Ian D.
name: Schmidt, Julia
name: Lannin, Natasha A.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: This study examined the patterns of informal (unpaid) caregiving provided to people after moderate to severe traumatic brain injury (TBI), explore the self-reported burden and preparedness for the caregiving role, and identify factors predictive of caregiver burden and preparedness. A cross-sectional cohort design was used. Informal caregivers completed the Demand and Difficulty subscales of the Caregiving Burden Scale; and the Mutuality, Preparedness, and Global Strain subscales of the Family Care Inventory. Chi-square tests and logistic regression were used to examine the relationships between caregiver and care recipient variables and preparedness for caregiving. Twenty-nine informal caregivers who reported data on themselves and people with a moderate to severe TBI were recruited (referred to as a dyad). Most caregivers were female (n = 21, 72%), lived with the care recipient (n = 20, 69%), and reported high levels of burden on both scales. While most caregivers (n = 21, 72%) felt “pretty well” or “very well” prepared for caregiving, they were least prepared to get help or information from the health system, and to deal with the stress of caregiving. No significant relationships or predictors for caregiver burden or preparedness were identified. While caregivers reported the provision of care as both highly difficult and demanding, further research is required to better understand the reasons for the variability in caregiver experience, and ultimately how to best prepare caregivers for this long-term role.
Additional file 1 of A single nucleotide polymorphism assay sheds light on the extent and distribution of genetic diversity, population structure and functional basis of key traits in cultivated north American cannabis
Creators: name: Henry, Philippe
name: Khatodia, Surender
name: Kapoor, Karan
name: Gonzales, Britni
name: Middleton, Alexis
name: Hong, Kevin
name: Hilyard, Aaron
name: Johnson, Steve
name: Allen, Davis
name: Chester, Zachary
name: Jin, Dan
name: Jule, José Carlos Rodriguez
name: Wilson, Iain
name: Gangola, Manu
name: Broome, Jason
name: Caplan, Deron
name: Adhikary, Dinesh
name: Deyholos, Michael K.
name: Morgan, Michael
name: Hall, Oliver W.
name: Guppy, Brent J.
name: Orser, Cindy
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1 : Supplementary Figure S1. Locus specific deviation from Hardy-Weinberg Equilibrium (HWE) for each samples seed stock. Heat map indicated P-value of test with pink boxes indication significant deviation from HWE. Supplementary Figure S2. Locus specific deviation from Hardy-Weinberg Equilibrium (HWE) for each inferred clusters. Heat map indicated P-value of test with pink boxes indication significant deviation from HWE.Supplementary Table S1. Seed stock specific population genetic metrics. Supplementary Table S2. Locus specific statistics. Supplementary Table S3. Table indicating the origin of each sample analysed in the study.
Exogenous Testosterone, Finasteride and Castration Effects on Testosterone, Insulin, Zinc and Chromium in Adult Male Rats
Creators: name: Namdar Yousefvand
name: Zarei, Fatemeh
name: Ghanbari, Ali
Publisher: name: the Pasteur Institute of Iran
Year: 1996
Subjects: subject: Basic Sciences

description: Iranian Biomedical Journal (IBJ); ISSN 1028-852X
Antibiotic Supplements Affect Electrophysiological Properties and Excitability of Rat Hippocampal Pyramidal Neurons in Primary Culture
Creators: name: Bahrami, Farideh
name: Mahyar Janahmadi
Publisher: name: the Pasteur Institute of Iran
Year: 1996
Subjects: subject: Basic Sciences

description: Iranian Biomedical Journal (IBJ); ISSN 1028-852X
The Burden of Biopsy-Proven Pediatric Celiac Disease in Ontario, Canada: Derivation of Health Administrative Data Algorithms and Determination of Health Services Utilization
Creators: name: Chan, Jason
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Celiac Disease
Health Administrative Data
Health Administrative Data Algorithm
Pediatrics

description: Introduction: The main objective of this thesis is to develop an algorithm to accurately identify cases of biopsy-proven Celiac Disease (CD) in children aged 6 months-14 years old from Ontario health administrative data. Method: CD cases diagnosed in 2005-2011 were identified from CHEO, and linked to the health administrative data to serve as reference for algorithms derivation. Algorithms based on outpatient physician visits for CD plus endoscopy billing code were constructed and tested. Results: The best algorithm selected based on performance from derivation study and clinical expertise consisted of an OHIP-based endoscopy billing claim followed by 1 or more adult or pediatric gastroenterologist encounters after the endoscopic procedure. The sensitivity, specificity, PPV, and NPV for the algorithm were 70.4%, >99.9%, 53.3% and >99.9% respectively. Conclusion: Study results suggest that the currently available Ontario health administrative data is not suitable for identifying incident pediatric CD cases.
Enzyme-like nanoparticle engineered-mesenchymal stem cell secreting HGF promotes visualized therapy for idiopathic pulmonary fibrosis in vivo
Creators: name: Bao, Hongying
name: Wu, Manxiang
name: Xing, Jie
name: Li, Zihou
name: Zhang, Yuenan
name: Wu, Aiguo
name: Li, Juan
Publisher: name: Zenodo
Year: 2024
Subjects: Database
Figure
Software tools

description: Stem cell therapy has emerged as a potential alternative treatment for idiopathic pulmonary fibrosis (IPF). However, its efficacy remains challenging due to factors such as ROS and inflammation in fibrotic lungs. Moreover, the distribution, migration, and survival of transplanted stem cells are still unclear, significantly impeding the clinical advancement of stem cell therapy. To tackle these challenges, we fabricate trimetallic-based nanocarriers (TBNCs) with enzyme-like activity and plasmid loading capabilities, aiming to efficiently eradicate ROS and facilitate delivery therapeutic genes and ultimately improve the therapeutic efficacy. Simultaneously, TBNCs function as an excellent CT contrast agent for tracking mesenchymal stem cells (MSCs), can improve the therapy by visualization-guiding. TBNCs was co-incubated with a hepatocyte growth factor plasmid gene to create TBNCs@pDNA, and then MSCs were modified with TBNCs@pDNA through endocytosis to generate engineered-MSCs, which demonstrate enhanced anti-oxidant and anti-inflammatory properties, thereby augmenting the therapeutic efficacy of MSCs. Finally, the in vivo CT tracking and therapy potential of engineered-MSCs is explored in IPF model mice. Overall, this study provides an efficient and forward-looking treatment approach for IPF and establishes a framework for a stem cell-based therapeutic system aimed at addressing lung disease.
description: Funding provided by: National Natural Science Foundation of ChinaROR ID: https://ror.org/01h0zpd94Award Number: 32025021
Funding provided by: National Natural Science Foundation of ChinaROR ID: https://ror.org/01h0zpd94Award Number: T2222021
Funding provided by: National Key R&D Program of ChinaCrossref Funder Registry ID: http://dx.doi.org/10.13039/501100012166Award Number: 2023YFC2415700
Funding provided by: China Postdoctoral Science FoundationROR ID: https://ror.org/0426zh255Award Number: 2022M723255
Funding provided by: Ningbo Natural Science FoundationCrossref Funder Registry ID: http://dx.doi.org/10.13039/100007834Award Number: 2023J369
La couverture médiatique de la violence psychologique en contexte de violence conjugale de 1988 à 2012
Creators: name: St-Hilaire, Nathalie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: violence psychologique
violence conjugale

description: La violence contre les conjointes était définie comme un problème individuel et isolé avant l’émergence du mouvement féministe occidental contemporain. Dans les années 1970 et 1980, avec l’émergence de ce mouvement, de nombreux groupes de femmes ont commencé à dénoncer la violence contre les conjointes et elles ont contribué à la définir comme un problème social. Les initiatives féministes ont porté sur des recherches développées afin de mieux comprendre et documenter cette manifestation de violence. Elles ont constaté que les conjointes étaient affectées par différentes formes de violence. Toutefois, dans un premier moment, la lutte s’est concentrée sur les formes physiques de la violence conjugale. Au fil des années, de nombreuses études ont porté sur la problématique de la violence conjugale. Toutefois, peu d’entre elles portent spécifiquement sur la violence psychologique en contexte de violence conjugale. Notre étude qui se veut une contribution à ce niveau répond à la question suivante : comment les médias écrits francophones couvrent-ils la violence psychologique dans un contexte de violence conjugale? Dans cette étude, nous avons analysé 180 articles de journaux canadiens francophones publiés entre 1988 et 2012 provenant de différents quotidiens. Ces articles présentent trois différentes représentations de la violence psychologique en contexte de violence conjugale : 1) la violence psychologique comme un phénomène spécifique isolé; 2) la violence psychologique comme une forme de violence parmi d’autres en contexte de violence conjugale; 3) la violence psychologique comme une forme de violence invisible. Nous soulignons qu’un petit nombre d’articles traitent de la violence psychologique et l’information portant sur cette forme de violence est succincte. Finalement, nous avons mis à jour que la conception de la violence conjugale véhiculée dans les articles est influencée par les discours féministes. Ainsi, les médias écrits conceptualisent la violence conjugale comme un problème social et définissent la violence conjugale à travers la domination masculine des femmes.
title: Unterstützung der Erarbeitung einer Verwaltungsvorschrift zum angemessenen Sicherheitsabstand
title: Unterstützung der Erarbeitung einer Verwaltungsvorschrift zum angemessenen Sicherheitsabstand
titleType: AlternativeTitle
Creators: name: Ewen, Christoph
name: Uth, Hans-Joachim
Publisher: name: Umweltbundesamt
Year: 2021
Subjects: subject: Seveso-III-Richtlinie
subject: Gefahrenabwehr
subject: Baurecht
subject: angemessener Sicherheitsabstand
subject: Störfälle
subject: Technische Anleitung Abstand
subject: Gefahrenpotential
subject: Bauplanung
subject: KAS18
subject: Planspiel
subject: Wirtschaft | Konsum

description: Gefahrstoffe mit dem Gefahrenmerkmal EUH029 ("Bilden im Kontakt mit Wasser giftige Gase") unterliegen der Störfall-Verordnung. Es wurde eine Kohorte von 30 Stoffen mit diesem Gefahrenmerkmal, die in der Praxis eine gewisse Bedeutung erlangt haben, analysiert. Das mit Abstand häufigste Hydrolyseprodukt (62%) ist Chlorwasserstoff, gefolgt von Phosphin mit 14%, und vereinzelt Fluorwasserstoff, Schwefelwasserstoff, Schwefeldioxid, Ammoniak, Stickoxide und Cyanwasserstoff. Die höchsten Gefahrenpotentialwerte werden für das Hydrolyseprodukt Phosphin gefolgt von Schwefeldioxid und Chlorwasserstoff ermittelt. Phosphin wird in der Kohorte ausschließlich aus Feststoffen generiert, Chlorwasserstoff und Schwefeldioxid hauptsächlich aus Flüssigkeiten. Zur standardisierten Berücksichtigung des Gefahrenpotentials dieser Stoffkategorie erscheint es notwendig hinsichtlich der Hydrolyseprodukte zu unterscheiden. Für die Abschätzung angemessener Sicherheitsabstände ist konservativ von einer 100% igen Umsetzung des Ausgangsstoffs in das Hydrolyseprodukt auszugehen und unter Berücksichtigung der stöchiometrischen Zusammenhänge die relevanten Mengen zu ermitteln und die Abstandsberechnung nach den "Handlungsempfehlungen..." vorzunehmen. Für phosphinentwickelnde (feste) Substanzen wird pauschal die Abstandskategorie VII-VIII (1000m - 1500m), für chlorwasserstoffentwickelnde (feste) Substanzen die Abstandskategorien III-IV (300m - 400m) als abdeckend vorgeschlagen. Für flüssige Stoffe aus denen Chlorwasserstoff generiert werden kann erscheint die Einhaltung eines Sicherheitsabstandes von 500m - 750 m in erster Näherung abdeckend. Quelle: Forschungsbericht
description: Ziel des Forschungsvorhabens war es, die Erarbeitung einer „Technischen Anleitung (TA) Abstand“ fachlich zu unterstützen.Mit dem Instrument eines Planspiels, wurden die Auswirkungen einer möglichen „Technischen Anleitung (TA) Abstand“ für die betroffenen Akteure benannt, bestehende Lücken identifiziert und Vorschläge zur Verbesserung unterbreitet. Innerhalb des Planspiels wurden ein Arbeitsstand einer TA Abstand, sowie zugehörige Erläuterungen und Definitionen anhand eines fiktiven Beispiels einem Praxistest unterzogen.Die Ergebnisse dienen dem ⁠BMU⁠ als Entscheidungshilfe für das weitere Vorgehen bei der Implementierung des mit der Seveso III Richtlinie neu eingeführten Begriffs „angemessener Sicherheitsabstand" in das Immissionsschutzrecht.
Analyzing Dynamic Football Passing Network
Creators: name: Rahnamai Barghi, Amir
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015

description: In this thesis we are concerned with the analysis of football matches represented as passing graphs, where players are nodes and directed edges indicate the passing of the ball. As opposed to previous work, we label the edges of the graph with the time instants when the ball is passed between two players, thus constructing a time-varying graph. We then employ techniques from social network analysis to study centrality roles and other indicators, keeping into account the evolution of the game in time. More precisely, we focus on degree centrality, closeness, betweenness, pagerank, eigenvector centrality, and clustering coefficient, and we compute these measures dividing the overall play time into time windows following two different models. The results are to be compared with a static analysis performed on a unique time window. Our study provides observations that are different and possibly more accurate than the ones that can be obtained by a static analysis, opening the door to a dynamic study of football matches.
Towards a new theory of entrepreneurship in culture and gender: a grounded study of Thailand's most successful female entrepreneurs
Creators: name: Hatcher, Caroline
name: Terjesen, Siri
Publisher: name: Swinburne
Year: 2024

description: This paper explores the phenomenon of Thailand's female entrepreneurship and accounts for some of the cultural drivers in the ways in which Thai women operate to be the leading country in the world for female entrepreneurship in terms of entrepreneurial activity. Based on interviews, media reporting, events attendance, and presentations collected during the annual conference for Leading Women Entrepreneurs of the World (LWEW) in Bangkok, Thailand. We report the ways in which leading Thai female entrepreneurs and male senior government officials explain the role of culture in legitimatising entrepreneurial activity. We develop a picture of female entrepreneurship is harmonious with Thai cultural and religious models of appropriate female behaviour and so provides some insights into the cultural reasons for prevalence of female entrepreneurial activity.
Lagarotis Forster 1869
Creators: name: Watanabe, Kyohei
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Lagarotis

description: Genus Lagarotis Förster, 1869
 Lagarotis Förster, 1869: 205. Type species: Ichneumon semicaligatus Gravenhorst, 1820. Designated by Viereck (1914).
 Daspletis Förster, 1869: 205. Type species: Ichneumon debitor Thunberg, 1822. Designated by Townes et al. (1965).
 Oneista Förster, 1869: 207. Type species: Oneista bohemani Kriechbaumer, 1892 (= Mesoleius ustulatus Holmgren, 1857). Designated by Viereck (1914).
 Nythophona Förster, 1869: 207. Type species: Mesoleius ustulatus Holmgren, 1857. Designated by Townes et al. (1965).
 Dysantes Förster, 1869: 207. Type species: Ichneumon debitor Thunberg, 1822. Designated by Perkins (1962). Lagarotus Thomson, 1892: 1881. Emendation.
This is the first record of this genus from Japan. In this study, I describe a new species below.
description: Published as part of Watanabe, Kyohei, 2024, Taxonomic Study of Japanese Ctenopelmatinae (Hymenoptera, Ichneumonidae), with Descriptions of 22 New Species, pp. 39-102 in Bulletin of the Kanagawa Prefectural Museum (Natural Science) 53 on page 76, DOI: 10.5281/zenodo.13237363
The Ghost in the (News) Room: Peace Journalism and its Limits in Kenya's Complex Media Environment
Creators: name: Weighton, Lisa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Peace journalism
Conflict sensitive journalism
Media
Kenya
Post-election violence

description: This thesis explores how peace journalism (PJ) translates into practice in the Kenyan media environment. Through the personal accounts of practicing reporters in Kenya, this research reveals the challenges and opportunities Kenyan journalist-participants faced while covering the 2013 presidential election. Through their personal experiences, this research reveals reporters were working in an exceptionally challenging media environment; one significantly shaped by the 2007 election and post-election violence. Participants identified numerous constraints that shaped their reporting practices, including structural constraints within their newsrooms and societal constraints in relation to ethnic identity. This thesis concludes that PJ has yet to offer sufficient concrete or practical solutions addressing these influencing factors, largely because of an overestimation of the agency journalists possess. Therefore, this research validates an existing body of research that suggests there is a need for PJ to consider factors outside of journalists themselves, which may constrain their work. The objective of the research is not to discredit the value of the tools PJ offers, but rather draw attention to the notion that those tools alone are insufficient.
Contractivity-Preserving Explicit 2-Step, 6-Stage, 6-Derivative Hermite-Birkhoff–Obrechkoff Ode Solver of Order 13
Creators: name: Alzahrani, Abdulrahman
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Contractivity preserving
explicit Hermite–Birkhoff–Obrechkoff method
Adams-Bashforth–Moulton method
omparing ODE solvers
N-body simulation

description: In this thesis, we construct a new optimal contractivity-preserving (CP) explicit, 2-step, 6-stage, 6-derivative, Hermite--Birkhoff--Obrechkoff method of order 13, denoted by HBO(13) with nonnegative coefficients, for solving nonstiff first-order initial value problems y'=f(t,y), y(t_0)=y_0. This new method is the combination of a CP 2-step, 6-derivative, Hermite--Obrechkoff of order 9, denoted by HO(9), and a 6-stage Runge-Kutta method of order 5, denoted by RK(6,5). The new HBO(13) method has order 13. We compare this new method, programmed in Matlab, to Adams-Bashforth-Moulton method of order 13 in PECE mode, denoted by ABM(13), by testing them on several frequently used test problems, and show that HBO(13) is more efficient with respect to the CPU time, the global error at the endpoint of integration and the relative energy error. We show that the new HBO(13) method has a larger scaled interval of absolute stability than ABM(13) in PECE mode.
SSA: Smart Surveillance Assistant for Mobile Devices
Creators: name: Kuang, Hao
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015

description: Over the past few years, the capability of smart devices has grown incessantly, and is showing no sign of slowing down. Along with the decreasing cost of manufacturing high definition surveillance cameras, this has led to the increased ease and convenience of installing surveillance cameras at or in private places. Various applications focus on home surveillance, however simply sending a high definition image does not satisfy all of the users’ needs. On a site that is monitored by a surveillance camera, the high-resolution surveillance camera streams its video to a user's handheld device. Unfortunately, such devices are unable to make use of the high-resolution video due to their limited display size and bandwidth, and the visual range is also a key problem. In this thesis, we propose a method to assist the mobile operator of the surveillance camera in focusing on sensitive regions of the videos. Our system automatically identifies relevant regions, combined with foreground detection and human body detection, which is referred to as object detection. A sensitivity map that represents those informative regions returned by the detection methods is accumulated over number of frames. It shows the collection of the sensitivity data in the video over a period of time. We then introduce a zoom strategy to ensure that the operator is able to see the fine details in these areas, while maintaining contextual knowledge. Regions of interest are identified using foreground detection as well as body detection. In order to accelerate the processing speed, we propose two optimization methods. The efficacy of the proposed methods is demonstrated through a user study, the results of which show that this approach is more successful than three comparable approaches used to get an understanding of the activities in a surveillance scene while maintaining context.
Characterisation of municipal solid waste composition into model inputs
Creators: name: Lamborn, Julia
Publisher: name: Swinburne
Year: 2024

description: Landfill gas generation models require the conversion of waste composition data into model inputs. Waste composition data is usually collected in the form of waste fractions: green waste, food, plastics, metals, paper, inert, etc. These waste fractions need to be characterised into cellulose, hemicellulose, lignin and inert; for inputs into models. This paper analyses the work that has been done on this characterisation and identifies where future work could be undertaken to help with the conversion of waste composition data into model inputs.
Atmospheric aerosol measurements in the German Ultrafine Aerosol Network (GUAN)
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015

description: Das deutsche Messnetz für ultrafeine Aerosolpartikel (GUAN, German Ultrafine Aerosol Network) ist eine kooperative Gemeinschaftsleistung zur Erforschung der gesundheits- und klimarelevanten Eigenschaften des atmosphärischen Aerosols in Deutschland. Diese Arbeit stellt Ergebnisse auf Grundlage der Langzeitbeobachtungen von Partikelanzahlgrößenverteilung und äquivalentem schwarzem Kohlenstoff (eBC) zwischen 2009 und 2014 vor. An den 17 Messstationen in Deutschland fand sich eine Variationsbreite bei der mittleren Gesamtpartikelanzahl (Durchmesserbereich 20 bis 800 nm) zwischen 850 und 10 500 p. cm-̲ und bei der Massenkonzentration von eBC zwischen 0,17 bis 2,8 Ţg m-̲. Analysen der Zeitreihen lieferten eine unerwartet deutliche und konsistente Abnahme der Immissionswerte von eBC an den meisten Stationen (Medianwert von -5 %/Jahr) und der Gesamtpartikelanzahl an allen Stationen (Medianwert von -4 %/Jahr). Die Abwärtstrends signalisieren, dass sich die gesellschaftlichen Bemühungen zur Luftreinhaltung, die im Partikelbereich ja schwerpunktmäßig auf die Partikelmassenkonzentration abzielen, offenbar auch positiv auf die Immissionswerte der Gesamtpartikelanzahl, der Zahl ultrafeiner Partikel und von Ruß auswirken.
Quelle: Atmospheric aerosol measurements in the German Ultrafine Aerosol Network (GUAN) : Part III: Black Carbon mass and particle number concentrations 2009-2014 [Elektronische Ressource] / W. Birmili ... - S. 479-488 : graph. Darst., Kt. In: Gefahrstoffe, Reinhaltung der Luft. - 75 (2015), H. 11/12, S. 479
description: The German Ultrafine Aerosol Network (GUAN) is a cooperative effort to scientifically explore the health and climate-related properties of the atmospheric aerosol in Germany. This work presents results on the basis of long-term observations of particle number size distributions and equivalent black carbon (eBC) between 2009 and 2014. At seventeen observation sites, we found a variations in mean total particle number concentration (diameter range 20-800 nm) between 850 and 10 500 p. cm-̲, and in eBC mass concentration between 0.17 and 2.8 Ţg m-̲. Time series trend analyses yielded a significant relative decrease in eBC mass concentration (median: -5 %/year) and in total particle number concentration (median: -4 %/year), which is rather consistent at almost all sites over Germany. The consistent downward trends suggest that air quality-related societal efforts, which have been targeted mainly at reductions of total particle mass emissions, have a beneficial effect on ambient total particle number, ultrafine particle number, and eBC mass concentrations as well.
Quelle: Atmospheric aerosol measurements in the German Ultrafine Aerosol Network (GUAN) : Part III: Black Carbon mass and particle number concentrations 2009-2014 [Elektronische Ressource] / W. Birmili ... - S. 479-488 : graph. Darst., Kt. In: Gefahrstoffe, Reinhaltung der Luft. - 75 (2015), H. 11/12, S. 479
Additional file 2 of The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions
Creators: name: Takalo, Mari
name: Wittrahm, Rebekka
name: Wefers, Benedikt
name: Parhizkar, Samira
name: Jokivarsi, Kimmo
name: Kuulasmaa, Teemu
name: Mäkinen, Petra
name: Martiskainen, Henna
name: Wurst, Wolfgang
name: Xianyuan Xiang
name: Marttinen, Mikael
name: Poutiainen, Pekka
name: Annakaisa Haapasalo
name: Hiltunen, Mikko
name: Haass, Christian
Publisher: name: figshare
Year: 2020
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2: Supplementary Figure 2. A) Immunoblot showing protein levels of Plcγ2 in Plcγ2-P522R knock-in (KI) and wild type (WT) bone marrow-derived macrophages (BMDMs. Quantitation showing Gapdh-normalized Plcγ2 protein levels in WT and KI BMDMs. Mean ± SD, % of WT, n = 3 per genotype. Independent samples t-test. B) Caspase-3/7 activation in WT and KI BMDMs after macrophage colony stimulation factor 1 (mCSF) withdrawal during 24 h. Four images were taken per well with a 20x objective every 4 h. Signals were normalized to the number of nuclei in the corresponding samples. Mean ± SEM, % of WT (24 h), n = 3 per genotype, 4 technical replicates. Independent samples t-test. C) Area under the curve (AUC) analysis indicating overall difference in phagocytic activity between WT and KI BMDMs. Mean ± SEM, % of WT, n = 6–7 per genotype, 3 technical replicates. Independent samples t-test. D) Immunoblot showing overexpression of Myc-tagged human PLCγ2-WT and PLCγ2-P522R constructs in BV2-cells using anti-Plcγ2 and anti-Myc antibodies. Quantitation showing β-actin-normalized PLCγ2 levels. Mean ± SD, % of CTRL, n = 4. Independent samples T-test, *p
Economic Sanctions and International Conflicts: The Case of Russia In Comparative Perspective
Creators: name: Chernousov, Pavel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Russia
sanctions
Ukraine

description: The subject of my thesis is the following: “Economic sanctions and international conflicts: the case of Russia in comparative perspective.” I will demonstrate the impact the economic sanctions have had on a state’s foreign policy; whether they have succeeded in persuading or forcing an embargoed country to change its geopolitical actions. I believe there is a case that argues that economic sanctions can work provided that they are applied in a right manner against properly defined targets with a clear purpose. My thesis will pursue a practical aim of providing direct and proven data based on empirical analysis to reinforce the theoretical base of the tool of economic sanctions. Apart from the research conducted on past case studies, the empirical research will concentrate on the Russian case. It will make use of think-tank reports, official documents and journalists’ investigations, in which the case for sanctions with regard to Russia is well-documented. In order to understand the development of the tool of economic sanctions, this paper will also outline their main characteristics. A historical and comparative approach is best suited for this purpose, as it offers solid theoretical data to reinforce the main arguments of the study. This information provides a useful tool for building this research project in a conclusive and definitive way.
Additional file 1 of Microperimetry as a diagnostic tool for the detection of early, subclinical retinal damage and visual impairment in multiple sclerosis
Creators: name: Rohowetz, Landon J.
name: Vu, Qui
name: Ablabutyan, Lilit
name: Gratton, Sean M.
name: Kunjukunju, Nancy
name: Billi S. Wallace
name: Koulen, Peter
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Figure S1. Diagnostic accuracy of microperimetry for detecting decreased average macular thickness. Figure S2. Diagnostic accuracy of microperimetry for detecting decreased central macular thickness. Figure S3. Diagnostic accuracy of low-contrast BCVA for detecting decreased average macular thickness. Figure S4. Diagnostic accuracy of low-contrast BCVA for detecting decreased central macular thickness.
Synchronous Optical and Electrical Measurements of Single DNA Molecules Translocating Through a Solid-State Nanopore
Creators: name: Bustamante, José
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Nanopore
Optical and Electrical DNA detection
Nanopore-based Optofluidic System
DNA
Fluorescence Microscopy
Noise Optimization

description: Nanopore sensors are emerging as a promising technology for single molecule analysis and polymer sequencing. Traditionally, measurements are taken by monitoring the ionic current through the nanopore, which gives information (e.g. size, shape, charge) about a molecule of interest while it is in the confined geometry of the nanopore. The dynamics of the molecule before the arrival to the nanopore, such as the capture dynamics, or molecular conformation prior to translocation, as well as clogging mechanisms and features of anomalous translocation events, are not assessed by the electrical measurements alone. To study the whole process of nanopore diffusion, capture and passage it is necessary to complement the electrical signal with another detection mode. Particularly, optical visualization of the molecules as they translocate through the nanopore has great potential. In this Thesis I present the design, construction, optimization and testing of a nanopore--‐based optofluidic instrument, which uses fluorescence microscopy to visualize individual fluorescently stained DNA molecules as they translocate a solid--‐state nanopore, while in parallel record the ionic current signal through the pore. The following challenges were overcome to achieve the integration of the optical and electrical systems: (i) the electrical detection system must account for the physical constrains of a wide field fluorescence microscope, and the optical system should in turn not affect the low--‐noise electrical detection of individual DNA molecules. The design of the instrument included a microfluidic device, so to position the nanopore within the working distance (<170--‐μm) of the microscope objective (Chapter 2). (ii) Electrical noise was optimized to a level that is indistinguishable from a standard (with no optics) nanopore system (Chapter 3). The custom instrument was used to demonstrate: 1) Electrical detection of DNA translocations with a laser light illuminating the nanopore; 2) Optical tracking of DNA capture and translocation dynamics; 3) Synchronization of the optical and electrical signals in preparation for simultaneous detection. In the process of noise optimization, a strong noise coupling between the illumination source and the ionic current was found, characterized and eliminated. Consequently, the noise performance of the custom instrument is the lowest of any other nanopore--‐based optofluidic systems described in the literature to date. This opens up the way to many new and exciting investigations of polymer translocation dynamics through nanoconfined geometries. Lastly, during the development of this custom instrument, a method to localize the fabrication of a nanopore by controlled dielectric breakdown on a membrane, with a focused laser beam, was discovered.
title: Umweltzeichen Blauer Engel für Computer
title: Umweltzeichen Blauer Engel für Computer
titleType: AlternativeTitle
Creators: name: Köhler, Andreas R.
name: Gröger, Jens
Publisher: name: My University
Year: 2021
Subjects: subject: Produktkennzeichnung
subject: Computer
subject: Energieverbrauch
subject: Blauer Engel
subject: Notebooks
subject: Emissionen
subject: Wirtschaft | Konsum

description: Der vorliegende Hintergrundbericht dient der Information über aktuelle und zukünftig absehbare Entwicklungen im Marktsektor Computertechnologie im Jahr 2016. Außerdem werden aktuelle Entwicklungen im regulatorischen Umfeld sowie bei anderen Umweltzeichen für Computer, insbesondere beim Energy Star analysiert. Alle weiteren Anforderungen des Umweltzeichens Blauer Engel für Computer werden ebenfalls auf ihre Aktualität hin überprüft und gegebenenfalls auf den neuesten Stand gebracht. Die Aktualisierung dient auch der Prüfung, ob weitere Anforderungen in die Vergabegrundlage aufgenommen werden sollen. Dieser Hintergrundbericht unterstützt die Diskussion zur weiteren Anpassung des Blauen Engels für Computer, ohne selbst die Vergabeanforderungen des Blauen Engels für Computer zu ändern. Die überarbeiteten Anforderungen werden für das Umweltzeichen für Computer DE-UZ 78, Ausgabe Januar 2017 berücksichtigt. Quelle: Forschungsbericht
description: This background report is intended to provide information on current and foreseeable future developments in the market sector of computers and notebooks in the year 2016. In addition, current developments in the regulatory environment and in other computer eco-labels, in particular Energy Star, are analysed. All other requirements of the Blue Angel Ecolabel for Computers are also reviewed and updated if necessary. The update also serves to check whether further requirements should be included in the basis for awarding the Blue Angel sign for computers. This background report supports the discussion on the further adaptation of the Blue Angel for computers without changing the Blue Angel award requirements for computers themselves. The revised criteria will be taken into account for the Blue Angel Ecolabel for Computer DE-UZ 78, Edition January 2017. Quelle: Forschungsbericht
description: Der vorliegende Hintergrundbericht dient der Information über aktuelle und zukünftig absehbare Entwicklungen im Marktsektor Computertechnologie im Jahr 2016. Außerdem werden aktuelle Entwicklungen im regulatorischen Umfeld sowie bei anderen Umweltzeichen für Computer, insbesondere beim Energy Star analysiert. Alle weiteren Anforderungen des Umweltzeichens Blauer Engel für Computer wurden auf ihre Aktualität hin überprüft und auf den neuesten Stand gebracht. Die überarbeiteten Vergabekriterien wurden beim Umweltzeichen für Computer DE-UZ 78, Ausgabe Januar 2017 berücksichtigt.
Supplementary document for A Photopolymerization Strategy for Preparation of Small-Diameter Artificial Blood Vessel with Micro-nano structure on Inner Wall - 5401890.pdf
Creators: name: Liu, Yonghao
name: Zhang, Jiawei
name: Li, Shunxin
name: Xia, Hong
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: supplementary materials
Post-Exercise Responses During Treatment Delays do not Affect the Physiological Responses to Cooling in Cold Water in Hyperthermic Individuals
Creators: name: Carlson, Mark
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Exertional Heat Stroke
Cold Water Immersion
Cardiovascular Strain
Heat Stress
Exercise Recovery

description: Victims of exertional heat stroke (EHS) in whom treatment is delayed have higher rates of multi-organ failure and a greater number of fatalities. Death related to EHS is preventable, through immediate treatment via cold-water immersion (CWI). To date little is known about the influence of treatment delays on core cooling following EHS. Thus we sought to examine the effects of treatment delays on cardiovascular and thermal responses prior to, during, and following CWI treatment in individuals with exercise-induced hyperthermia. Our findings demonstrate that treatment delays resulted in a sustained level of hyperthermia and cardiovascular strain that significantly increased the time an individual is at risk to the potential lethal effects of EHS. Moreover, we report that cold water immersion treatment is powerful enough to overcome the adverse effects of treatment delays and rapidly reduce core temperatures while facilitating the re-establishment of blood pressure towards normal resting levels.
The opportunity recognition process and new venture start-up motivators: The real options approach
Creators: name: Baltrusaityte-Axelson, Jurgita
Publisher: name: Swinburne
Year: 2024

description: This study utilizes the Panel Study of Entrepreneurial Dynamics (PSED) to examine the decision making process of nascent entrepreneurs (NEs) in the United States. Drawing on the real options theory, I check whether the motivators that drive the start-up of the new business venture (NBV) differ between the proactive NEs (i.e., those individuals who proactively look for business opportunities with the goal of becoming an entrepreneur) and the reactive NEs (i.e., those individuals who reactively decide to become an entrepreneur only after a business opportunity presents itself). OpR is one of the central areas of entrepreneurial research. Stevenson and Jarrilo (1990) proposed a definition of entrepreneurship that emphasized opportunity: ”the essence of entrepreneurship is the willingness to pursue opportunity, regardless of the resources under control.” Venkataraman (1997) concluded that entrepreneurship requires both enterprising individuals and lucrative opportunities (i.e., entrepreneurship cannot exist without OpR). It has been argued that entrepreneurs are stimulated by different motivators depending on their gender, ethnicity, desire for independence and other factors and circumstances. However, I believe that many of the previously researched factors (e.g., gender and ethnicity) are, in fact, secondary to the fundamental distinction between entrepreneurs in regards of their OpR: reactive vs. proactive. Reactive NEs can be hypothesized to start their NBVs for different reasons than proactive NEs. According to McMullen and Shepherd (2002), little attention has been given to the research on motivation, and ”this neglect is disconcerting.” Whereas overall research on motivation is lacking, research on reactive vs. proactive OpR and motivations appears to be non-existent. Real options theory leads us to believe that NEs are making discrete choices under uncertainty in a way that maximizes their learning and contains downside risk while allowing them to capitalize on upside opportunities. Real option theory is particularly suitable for assessing uncertain projects in the rapidly changing competitive environment and has recently become a focus of managerial research (e.g., McGrath 1999; 2003).
Correction: Breakfast in Canada: Prevalence of Consumption, Contribution to Nutrient and Food Group Intakes, and Variability across Tertiles of Daily Diet Quality. A Study from the International Breakfast Research Initiative. Nutrients 2018, 10, 985
Creators: name: Barr, Susan I.
name: Vatanparast, Hassan
name: Smith, Jessica
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: The authors wish to make a correction to the published version of their paper [...]
Additional file 1 of Classification of Parkinson’s disease and essential tremor based on balance and gait characteristics from wearable motion sensors via machine learning techniques: a data-driven approach
Creators: name: Moon, Sanghee
name: Hyun-Je Song
name: Vibhash D. Sharma
name: Lyons, Kelly E.
name: Pahwa, Rajesh
name: Abiodun E. Akinwuntan
name: Devos, Hannes
Publisher: name: figshare
Year: 2020
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 1: Supplementary Table 1. Balance and gait features and description.
Dynamiques de la végétation en regard des variabilités climatiques au cours de l'Holocène tardif, Outaouais, Québec.
Creators: name: Lafontaine-Boyer, Karelle K.L.B.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Palynologie
Paléoclimatologie
Paléoécologie
Holocène tardif
Changements climatiques
Québec
Forêt décidue
Incendie forestier
Varves

description: Un profil pollinique provenant d'un lac possédant des sédiments laminés (varves), le lac Brûlé (45°43'09" N, 75°26'32"O 270m), a servi à étudier l'histoire de la végétation et du climat dans l'Outaouais au cours de l'Holocène tardif. Au cours des 1400 dernières années, la végétation de l'Outaouais a été dominée par des espèces arboréennes telles que Tsuga, Fagus, Betula, Acer, Pinus et Picea. Des modifications majeures s'opèrent dans les spectres polliniques vers 1375 AD. Les analyses des micro-charbons et les évidences d'une succession écologique secondaire indiquent que ces changements sont attribuables à un incendie forestier. Une diminution abrupte de l’influx pollinique entre 1600 et 1700 AD suggère qu’une dégradation du climat sous un certain seuil a entraîné une réponse rapide du milieu forestier. Les changements observés lors du Petit-Âge glaciaire suggèrent que les variations climatiques de courte durée affectent la production pollinique et que ces changements sont enregistrés par les diagrammes polliniques à haute résolution temporelle.
Strategic ambiguity as a discourse practice: the role of keywords in the discourse on 'sustainable' biotechnology
Creators: name: Leitch, Shirley
name: Davenport, Sally
Publisher: name: Swinburne
Year: 2024

description: In this article we examined the ways in which strategic ambiguity (Eisenberg, 1984) in the use of keywords (Williams, 1976/1983) served an enabling function within a discourse marked by conflict and ideological divisions. Our analysis focused on the intertextual relationships between five documents intended by the government to guide the development of biotechnology in New Zealand. Through our analysis we identified 'sustainability' as a keyword and three major roles for the deployment of the discourse strategy of strategic ambiguity in the use of this keyword. First, strategic ambiguity lent an internal and intertextual coherence to the texts (albeit superficial). Second, it allowed multiple perspectives and objectives to co-exist. Third, strategic ambiguity facilitated the participation of discourse actors who subscribed to ideologies that were more or less incommensurable.
Additional file 2 of Classification of Parkinson’s disease and essential tremor based on balance and gait characteristics from wearable motion sensors via machine learning techniques: a data-driven approach
Creators: name: Moon, Sanghee
name: Hyun-Je Song
name: Vibhash D. Sharma
name: Lyons, Kelly E.
name: Pahwa, Rajesh
name: Abiodun E. Akinwuntan
name: Devos, Hannes
Publisher: name: figshare
Year: 2020
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 2: Supplementary Table 2. Performance across different machine learning models with and without SMOTE.
Modèles procéduraux littéraires et création sur ordinateur
Creators: name: Rucar, Yan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: littérature électronique
contrainte
clinamen
générateur de texte
appropriation
adaptation
visuel
interactivité
mécanicité
illisibilité
interférence

description: Cette thèse a pour problématique la relation entre le texte électronique et la notion de contrainte. Afin d’étudier la rencontre de la création contrainte avec l’environnement électronique, le corpus est constitué de deux séries d’oeuvres positionnées différemment par rapport au média numérique. Les sections 1 et 2 du Chapitre I traitent de textes contraints produits par des auteurs hors du contexte numérique et qui furent intégrés à l’écran d’ordinateur lors de la transmédiatisation de l’oeuvre imprimée. Ces sections exposent les principes d’écriture contrainte employés dans ces oeuvres, les versions électroniques de celles-ci étant analysées dans le chapitre II. La seconde partie du corpus est comprise par des oeuvres dont la procédure contraignante est électronique, des textes imprimés étant appropriés via des algorithmes. Ces procédures électroniques font intervenir des générateurs combinatoires de textes, qui redistribuent aléatoirement les composants des textes appropriés. Lorsque le texte n’est pas semblablement transformé, l’écrit approprié est livré à une autre forme de systématisme, qui altère l’oeuvre originale en la faisant défiler sur l’écran selon des lois perturbant l’appréhension du texte. Les spécificités générales des générateurs de textes sont exposées dans la section 3 du chapitre I. Les générateurs inclus dans le corpus sont analysés dans le chapitre III. L’étude de l’interaction entre la contrainte écrite et l’environnement électronique, entre des textes appropriés et des procédures électroniques, l’analyse des divergences et convergences entre ces deux formes de productions contraintes, permettra de définir une textualité électronique fondée sur un système.
Activation of Sigma-1 Receptors Increases Expression, Trafficking, and Surface Levels of NMDA Receptors
Creators: name: Pabba, Mohan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: NMDA receptors
Sigma-1 receptors
Synaptic plasticity

description: Sigma-1 receptors (σ-1Rs) are chaperone-like proteins that are broadly distributed throughout the central nervous system and in other tissues. They have been implicated in several physiological and pathological processes, primarily by their ability to modulate certain voltage- and ligand-gated ion channels. Growing evidence suggests that σ-1Rs regulate the functions of ion channels, such as voltage-gated K+ 1.2 (Kv 1.2) and the human Ether-à-go-go-Related Gene (hERG) ion channels, by modulating their expression, trafficking, and targeting. While it is well documented that σ-1Rs enhance the function of N-methyl-D-aspartate receptors (NMDARs), the mechanisms of this enhancement remain poorly understood. Using biochemical methods, we show that 90 minutes after intraperitoneal (i.p.) injection of σ-1R agonists such as (+)-SKF 10,047 (SKF) or (+)-Pentazocine (PTZ) (2 mg/kg), there is an increase in the expression of GluN2 subunits of NMDARs and postsynaptic density protein-95 (PSD-95) in the rat hippocampus. Following activation of σ-1Rs, co-immunoprecipitation (Co-IP) experiments reveal an increased interaction between σ-1Rs and NMDAR subunits; sucrose gradient centrifugation demonstrates an increase in the protein levels of GluN2 subunits in vesicular compartment; and biotinylation shows an increase in the surface levels of GluN2A-containing NMDARs. Taken together, our results suggest σ-1Rs may enhance NMDARs function by increasing their expression, trafficking, and surface levels. This σ-1R-mediated increase in NMDAR expression and surface levels might be involved in several physiological processes such as learning and memory. Our findings also suggest that σ-1Rs could form a potential target for designing novel antipsychotics.