Additional file 1 of A causal effects of gut microbiota in the development of migraine
Creators: name: He, Qiang
name: Wang, Wenjing
name: Xiong, Yang
name: Tao, Chuanyuan
name: Ma, Lu
name: Ma, Junpeng
name: You, Chao
Publisher: name: figshare
Year: 2023
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. Single-nucleotide polymorphisms used as instrumental variables at the threshold of P&lt;1e-5 in MR analysis. Table S2. Single-nucleotide polymorphisms used as instrumental variables at the threshold of P&lt;1e-8 in IHGC datasets in MR analysis. Table S3. Single-nucleotide polymorphisms used as instrumental variables at the threshold of P&lt;1e-8 for FinnGen datasets in MR analysis. Table S4. Single-nucleotide polymorphisms used as instrumental variables for migraine at the threshold of P&lt;1e-5 in IHGC datasets in reverse MR analysis. Table S5. Single-nucleotide polymorphisms used as instrumental variables for MA at the threshold of P&lt;1e-5 in IHGC datasets in reverse MR analysis. Table S6. Single-nucleotide polymorphisms used as instrumental variables for MO at the threshold of P&lt;1e-5 in IHGC datasets in reverse MR analysis. Table S7. Single-nucleotide polymorphisms used as instrumental variables for migraine at the threshold of P&lt;1e-5 in FinnGen datasets in reverse MR analysis. Table S8. Single-nucleotide polymorphisms used as instrumental variables for MA at the threshold of P&lt;1e-5 in FinnGen datasets in reverse MR analysis. Table S9. Single-nucleotide polymorphisms used as instrumental variables for MO at the threshold of P&lt;1e-5 in FinnGen datasets in reverse MR analysis. Table S10. Single-nucleotide polymorphisms used as instrumental variables for mmigraine at the threshold of P&lt;1e-8 in IHGC datasets in reverse MR analysis. Table S11. Single-nucleotide polymorphisms used as instrumental variables for MO at the threshold of P&lt;1e-8 in IHGC datasets in reverse MR analysis. Table S12. MR results of causal links between gut microbiome and migraine at the threshold of P&lt;1e-5 in the IHGC GWAS datasets in MR analysis. Table S13. MR results of causal links between gut microbiome and migraine with aura at the threshold of P&lt;1e-5 with aura in the IHGC GWAS datasets in MR analysis. Table S14. MR results of causal links between gut microbiome and migraine without aura at the threshold of P&lt;1e-5 in the IHGC GWAS datasets in MR analysis. Table S15. The MR-Egger and Cochran’s Q test of gut microbiome on migraine, migraine with aura and migraine without aura at the threshold of P&lt;1e-5 in the IHGC GWAS datasets in MR analysis. Table S16. Positive MR results of causal links between gut microbiome and migraine, migraine with aura and migraine without aura at the threshold of P&lt;1e-5 in the FinnGen GWAS datasets in MR analysis. Table S17. MR results of causal links between gut microbiome and migraine at the threshold of P&lt;1e-5 in the FinnGen GWAS datasets in MR analysis. Table S18. MR results of causal links between gut microbiome and MA with aura at the threshold of P&lt;1e-5 in the FinnGen GWAS datasets in MR analysis. Table S19. MR results of causal links between gut microbiome and MO without aura at the threshold of P&lt;1e-5 in the FinnGen GWAS datasets in MR analysis. Table S20. The MR-Egger and Cochran’s Q test of gut microbiome on migraine, migraine with aura and migraine without aura at the threshold of P&lt;1e-5 in the FinnGen GWAS datasets in MR analysis. Table S21. MR results of causal links between gut microbiome and migraine, migraine with aura and migraine without aura in the IHGC GWAS datasets at the threshold of P&lt;1e-8 in MR analysis. Table S22. MR results of causal links between gut microbiome and migraine, migraine with aura and migraine without aura in the FinnGen GWAS datasets at the threshold of P&lt;1e-8 in MR analysis. Table S23. The MR-Egger and Cochran’s Q test of migraine, migraine with aura and migraine without aura on gut microbiome in the IHGC GWAS datasets at the threshold of P&lt;1e-5 in reverse MR analyses. Table S24. The MR-Egger and Cochran’s Q test of migraine, migraine with aura and migraine without aura on gut microbiome in the FinnGen GWAS datasets at the threshold of P&lt;1e-5 in reverse MR analyses. Table S25. MR results of causal links between migraine, migraine with aura and migraine without aura on gut microbiome at the threshold of P&lt;1e-8 in the IHGC GWAS datasets in the reverse MR analyses. Table S26. MR results of causal links between migraine, migraine with aura and migraine without aura on gut microbiome at the threshold of P&lt;1e-8 in the FinnGen GWAS datasets in the reverse MR analyses. Figure S1. The leave-one-out analyses of bacterial traits for migraine at the threshold of P&lt;1e-5 in IHGC datasets in MR analyses. Figure S2. The leave-one-out analyses of bacterial traits for MA at the threshold of P&lt;1e-5 in IHGC datasets in MR analyses. Figure S3. The leave-one-out analyses of bacterial traits for MO at the threshold of P&lt;1e-5 in IHGC datasets in MR analyses. Figure S4. The common bacterial traits among migraine, MA, and MO at the threshold of P&lt;1e-5 in IHGC datasets in MR analyses. Figure S5. Causal effect of the gut microbiome on migraine, MA, MO at the threshold of P&lt;1e-5 in FinnGen datasets based on MR analyses in MR analyses. Figure S6. Causal effect estimates of the gut microbiome on migraine at the threshold of P&lt;1e-5 in FinnGen datasets in MR analyses. Figure S7. Causal effect estimates of the gut microbiome on MA at the threshold of P&lt;1e-5 in FinnGen datasets in MR analyses. Figure S8. Causal effect estimates of the gut microbiome on MO at the threshold of P&lt;1e-5 in FinnGen datasets in MR analyses. Figure S9. The leave-one-out analyses of bacterial traits for migraine at the threshold of P&lt;1e-5 in FinnGen datasets in MR analyses. Figure S10. The leave-one-out analyses of bacterial traits for MA at the threshold of P&lt;1e-5 in IHGC datasets in MR analyses. Figure S11. The leave-one-out analyses of bacterial traits for MO at the threshold of P&lt;1e-5 in IHGC datasets in MR analyses. Figure S12. The common bacterial traits among migraine, MA, and MO at the threshold of P&lt;1e-5 in FinnGen datasets in MR analyses. Figure S13. Causal effect estimates of the migraine on gut microbiome at the threshold of P&lt;1e-5 in IHGC datasets in reverse MR analyses. Figure S14. Causal effect estimates of the MA on gut microbiome at the threshold of P&lt;1e-5 in IHGC datasets in reverse MR analyses. Figure S15. Causal effect estimates of the MO on gut microbiome at the threshold of P&lt;1e-5 in IHGC datasets in reverse MR analyses. Figure S16. The leave-one-out analyses of migraine on gut microbiome at the threshold of P&lt;1e-5 in IHGC datasets in reverse MR analyses. Figure S17. The leave-one-out analyses of MA on gut microbiome at the threshold of P&lt;1e-5 in IHGC datasets in reverse MR analyses. Figure S18. The leave-one-out analyses of MO on gut microbiome at the threshold of P&lt;1e-5 in IHGC datasets in reverse MR analyses. Figure S19. Causal effect estimates of the migraine on gut microbiome at the threshold of P&lt;1e-5 in FinnGen datasets in reverse MR analyses. Figure S20. Causal effect estimates of MA on gut microbiome at the threshold of P&lt;1e-5 in FinnGen datasets in reverse MR analyses. Figure S21. Causal effect estimates of MO on gut microbiome at the threshold of P&lt;1e-5 in FinnGen datasets in reverse MR analyses. Figure S22. The leave-one-out analyses of migraine on gut microbiome at the threshold of P&lt;1e-5 in FinnGen datasets in reverse MR analyses. Figure S23. The leave-one-out analyses of MA on gut microbiome at the threshold of P&lt;1e-5 in FinnGen datasets in reverse MR analyses. Figure S24. The leave-one-out analyses of MO on gut microbiome at the threshold of P&lt;1e-5 in FinnGen datasets in reverse MR analyses. Figure S25. Causal effect estimates of migraine on gut microbiome at the threshold of P&lt;1e-8 in IHGC datasets in reverse MR analyses. Figure S26. Causal effect estimates of MO on gut microbiome at the threshold of P&lt;1e-8 in IHGC datasets in reverse MR analyses. Figure S27. The leave-one-out analyses of migraine on gut microbiome at the threshold of P&lt;1e-8 in IHGC datasets in reverse MR analyses. Figure S28. The leave-one-out analyses of MO on gut microbiome at the threshold of P&lt;1e-8 in IHGC datasets in reverse MR analyses.