cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Supplemental Material, AuthorBiographies - Semiparametric APC analysis of destination choice patterns: Using generalized additive models to quantify the impact of age, period, and cohort on travel distances
Creators: name: Weigert, Maximilian
name: Bauer, Alexander
name: Gernert, Johanna
name: Karl, Marion
name: Nalmpatian, Asmik
name: Küchenhoff, Helmut
name: Schmude, Jürgen
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Economics
subject: 150402 Hospitality Management
subject: FOS: Economics and business

description: Supplemental Material, AuthorBiographies for Semiparametric APC analysis of destination choice patterns: Using generalized additive models to quantify the impact of age, period, and cohort on travel distances by Maximilian Weigert, Alexander Bauer, Johanna Gernert, Marion Karl, Asmik Nalmpatian, Helmut Küchenhoff and Jürgen Schmude in Tourism Economics
Additional file 1 of Demographic and clinical characteristics, seizure disorders, and antiepileptic drug usage in different types of corpus callosum disorders: a comparative study in children
Creators: name: Fu, Ru-Huei
name: Wu, Po-Yen
name: Chou, I-Ching
name: Lin, Chien-Heng
name: Hong, Syuan-Yu
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Neuroscience
Biotechnology
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Supplementary Material 1
E03825: The Church Calendar of Ioane Zosime, compiled in Georgian in the 10th c., based however on 5th-7th c. prototypes from Palestine, commemorates on 7 August possibly *Moses (Old Testament prophet and lawgiver, S00241), 'Moses son of Ephemianos' (possibly *Alexios/the 'Man of God', ascetic of Edessa, S01211), and *Eusignios (soldier and martyr of Antioch, S01369).
Creators: name: Bryan
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: ზ. სოფონია წ(მიდა)ს, ლიტანია, და მოსჱსი ეფემიანეს ძისაჲ, და ტაბორიაჲსაჲ :.:., და ევსუგნი მ(ო)წ(ა)მ(ი)ს(ა)ჲ, და ფერ(ი)სცვ(ა\ლ)ებ(ა)ჲვე.

7 August. Litany in the Saint Sophia, and Moses son of Ephemianos and 'Taboria' [?] and martyr Eusignios and the same Transfiguration.

Text: Garitte 1958, 82-87; Electronic text: Gippert 2017, http://titus.uni-frankfurt.de/texte/etcg/cauc/ageo/liturg/iozosca2/iozos.htm (26.12.17); Translation: N. Aleksidze.
sj-pdf-1-ica-10.1177_0276236620988510 - Supplemental material for Therapeutic Benefits of Adult Doll Play
Creators: name: Ignacio, Angelie
name: Cupchik, Gerald
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-pdf-1-ica-10.1177_0276236620988510 for Therapeutic Benefits of Adult Doll Play by Angelie Ignacio and Gerald Cupchik in Imagination, Cognition and Personality
E03826: The Church Calendar of Ioane Zosime, compiled in Georgian in the 10th century, based however on 5th-7th c. prototypes from Palestine, commemorates on 8 August *Theodore (soldier and martyr of Amaseia and Euchaita, S00480), *Thyrsos (martyr of Bithynia, S00612), *Sergios (soldier and martyr of Rusafa, S00023), possibly *Elianos (martyr of Aman, S00889) or Emilianos, a 9th c. confessor under Leo the Armenian, *Viktor and Stephanis/Corona (martyrs of Damascus, S01620) and Marinus (identity uncertain) and *Melchizedek (king and priest of the Old Testament, S01783).
Creators: name: Naleksidze
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: ჱ. თევდორჱსი და თურსოჲსი და სერგისისი მ(ო)წ(ამე)თ(ა), და ელიაჲსი, და სოფია წ(მი)დისა სატფური, ბიკტოჳრ მ(ო)წამისაჲ :.:., და მარინაჲსი, და სტეფ(ა)ნიდჱსი, მელქიზედეკისი.

8 August. Theodore and Thyrsos and Sergios the martyrs and Elia [=Elianos] and in Saint Sophia the dedication of martyr Victor and Marinus and 'Stephanida' [presumably = Stephanis] and Melkisedek.

Text: Garitte 1958, 82-87; Electronic text: Gippert 2017, http://titus.uni-frankfurt.de/texte/etcg/cauc/ageo/liturg/iozosca2/iozos.htm (26.12.17); Translation: N. Aleksidze.
Supplemental Material, Ms1_Rebuttal_table_Reviewer_Comments - Experiences of Women Survivors of Childhood Sexual Abuse in Relation to Nonsupportive Significant Adults: A Scoping Review
Creators: name: Brits, Bianca
name: Walker-Williams, Hayley
name: Ansie Fouché
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material, Ms1_Rebuttal_table_Reviewer_Comments for Experiences of Women Survivors of Childhood Sexual Abuse in Relation to Nonsupportive Significant Adults: A Scoping Review by Bianca Brits, Hayley Walker-Williams and Ansie Fouché in Trauma, Violence, & Abuse
Additional file 2 of Demographic and clinical characteristics, seizure disorders, and antiepileptic drug usage in different types of corpus callosum disorders: a comparative study in children
Creators: name: Fu, Ru-Huei
name: Wu, Po-Yen
name: Chou, I-Ching
name: Lin, Chien-Heng
name: Hong, Syuan-Yu
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Neuroscience
Biotechnology
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Supplementary Material 2
Additional file 3 of Demographic and clinical characteristics, seizure disorders, and antiepileptic drug usage in different types of corpus callosum disorders: a comparative study in children
Creators: name: Fu, Ru-Huei
name: Wu, Po-Yen
name: Chou, I-Ching
name: Lin, Chien-Heng
name: Hong, Syuan-Yu
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Neuroscience
Biotechnology
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Supplementary Material 3
E03827: The Church Calendar of Ioane Zosime, compiled in Georgian in the 10th century, based however on 5th-7th c. prototypes from Palestine, commemorates on 9 August *Aaron (Old Testament prophet, S01427), *Pantaleōn/Panteleēmōn (martyr of Nicomedia, during the Diocletian persecution of 305, S00596), *Matthias (the Apostle, S01784), *Dometios (monk and martyr of Syria under Julian, S00414), and Emilianos, a 9th c. confessor under Leo the Armenian.
Creators: name: Bryan
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: თ. აჰრონ მღდ(ე)ლის(ა)ჲდა პატელეონ მ(ო)წ(ა)მ(ი)ს(ა)ჲ, და მატათია მ(ო)ც(ი)ქ(უ)ლ(ი)ს(ა)ჲ, და წამებაჲ დომენტოჲსი და ემილიანოსისი.

9 August. Priest Aaaron and martyr Pantaleon and Apostle Matthias and martyrdom of Dometios and Emilianos.

Text: Garitte 1958, 82-87; Electronic text: Gippert 2017, http://titus.uni-frankfurt.de/texte/etcg/cauc/ageo/liturg/iozosca2/iozos.htm (26.12.17); Translation: N. Aleksidze.
Physicochemical and Spectroscopic Characterization of Biofield Treated Triphenyl Phosphate
Creators: name: Trivedi, Mahendra Kumar
Publisher: name: SMN - The ScienceMedia Network
Year: 2017
Subjects: Natural Sciences
Chemistry

description: Triphenyl phosphate (TPP) is a triester of phosphoric acid and phenol. It is commonly used as a fire-retarding agent and plasticizer for nitrocellulose and cellulose acetate. The present study was an attempt to evaluate the impact of biofield treatment on physicochemical and spectroscopic properties of TPP. The study was carried out in two groups i.e. control and treatment. The treatment group was subjected to Mr. Trivedi’s biofield treatment. The control and treated samples of TPP were characterized using X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier transform infrared (FT-IR), and ultraviolet-visible (UV-Vis) spectroscopy. XRD study revealed the decrease in crystallite size (6.13%) of treated TPP that might be due to presence of strains and increase in atomic displacement from their ideal lattice positions as compared to control sample. DSC thermogram of treated TPP showed the increase in melting temperature (1.5%) and latent heat of fusion (66.34%) with respect to control. TGA analysis showed the loss in weight by 66.79% in control and 47.96% in treated sample. This reduction in percent weight loss suggests the increase of thermal stability in treated sample as compared to control. FT-IR and UV spectroscopic results did not show the alteration in the wavenumber and wavelength of FT-IR and UV spectra, respectively in treated TPP with respect to control. Altogether, the XRD and DSC/TGA results suggest that biofield treatment has the impact on physical and thermal properties of treated TPP.
Use of Energy Healing Medicine Against Escherichia coli for Antimicrobial Susceptibility, Biochemical Reaction and Biotyping
Creators: name: Branton, Alice
Publisher: name: SMN - The ScienceMedia Network
Year: 2017
Subjects: Natural Sciences
Biology

description: Escherichia coli (E. coli) infections are the major health concern, as it causes infections in human mainly in urinary tract, ear, and wound infections. The present study evaluates the impact of biofield energy treatment on E. coli regarding antimicrobial sensitivity assay, biochemical study and biotype number. Four multidrug resistant (MDR) clinical lab isolates (LSs) of E. coli (LS 12, LS 13, LS 42, and LS 51) were taken in two groups i.e. control and treated. After treatment, above mentioned parameter were evaluated on day 10 in control and treated samples using MicroScan Walk-Away® system. The antimicrobial sensitivity assay was reported with 46.67% alteration (14 out of 30 tested antimicrobials) in treated group of MDR E. coli isolates. The minimum inhibitory concentration (MIC) study showed the alteration in MIC values of about 34.37% (11 out of 32) tested antimicrobials, after biofield treatment in clinical isolates of E. coli. Piperacillin/tazobactam was reported with improved sensitivity and four-fold decrease in the MIC value (64 to ≤16 μg/mL) in LS 42, as compared with the control. Amoxicillin/kclavulanate reported with improved sensitivity pattern from resistance to susceptible, with two-fold decrease in MIC value (>16/8 to ≤8/4 μg/mL) in biofield treated LS 51. Further, biochemical study showed 24.24% alteration (8 out of 33) in tested biochemical reactions after treatment among four isolates of E. coli as compared to the control. A change in biotype number (7774 4272) was reported as compared to the control, (7311 4012), with new organism identified as Klebsiella pneumoniae in biofield treated LS 13 with respect to the control organism, E. coli. Overall, data suggested that Mr. Trivedi’s biofield energy treatment can be applied to alter the antimicrobial sensitivity, biochemical reactions and biotype number of E. coli.
E03828: The Church Calendar of Ioane Zosime, compiled in Georgian in the 10th c., based however on 5th-7th c. prototypes from Palestine, commemorates on 10 August *Laurence/Laurentius (deacon and martyr of Rome, S01229), and *Phokas (martyr of Sinope, S00052) or *Phokas (martyr of Antioch, S00413).
Creators: name: Naleksidze
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: ი. ელიანოს მარტჳლისაჲ :.:., და ლავრენტისი, და ფოკა მ(ო)წ\(ა)მის(ა)ჲ.

10 August. Martyr Elianos and Laurentius and martyr Phokas.

Text: Garitte 1958, 82-87; Electronic text: Gippert 2017, http://titus.uni-frankfurt.de/texte/etcg/cauc/ageo/liturg/iozosca2/iozos.htm (26.12.17); Translation: N. Aleksidze.
T16G12.6/IMPORTIN 13-mediated cytoplasm-to-nucleus transport of the THAP transcription factor LIN-15B controls autophagy and lysosome function in C. elegans
Creators: name: Ma, Xiaoli
name: Gou, Xiaomeng
name: Zhang, Hong
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Environmental Sciences not elsewhere classified
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Mental Health
subject: Plant Biology
subject: Computational Biology

description: Transcriptional regulation of genes involved in the macroautophagy/autophagy-lysosome pathway acts as an important mechanism for controlling autophagy activity. The factors that globally regulate autophagy activity at the transcriptional level during C. elegans development remain unknown. Here we showed that the THAP domain-containing transcription factor LIN-15B modulates autophagy activity during C. elegans development. Loss of function of lin-15B suppresses the autophagy defect caused by impaired autophagosome maturation and promotes lysosome biogenesis and function. LIN-15B maintains the repressed state of genes involved in the autophagy pathway. Accordingly, loss of function of lin-15B upregulates a plethora of genes involved in autophagosome formation and maturation as well as lysosome biogenesis and function. The cytoplasm-to-nucleus translocation of LIN-15B is mediated by the T16G12.6/IMPORTIN 13/IPO-13 receptor and modulated by nutrient status. Our study uncovers that LIN-15B integrates environmental cues into transcriptional control of a network of genes involved in autophagy in C. elegans. Abbreviations: ATG: autophagy related; DIC: differential interference contrast; EPG: ectopic PGL granules; ER: endoplasmic reticulum; FOXO: forkhead box O; GFP: green fluorescent protein; SQST-1: SeQueSTosome related 1; SynMuv: synthetic multivulva; IPO-13: importin 13; TFEB: transcription factor EB.
Additional file 1 of Healthcare-associated infections and antimicrobial use in acute care hospitals in Greece, 2022; results of the third point prevalence survey
Creators: name: Palaiopanos, Konstantinos
name: Krystallaki, Dimitra
name: Mellou, Kassiani
name: Kotoulas, Petros
name: Kavakioti, Christina-Anna
name: Vorre, Styliani
name: Vertsioti, Georgia
name: Gkova, Maria
name: Maragkos, Antonios
name: Tryfinopoulou, Kyriaki
name: Paraskevis, Dimitrios
name: Tsiodras, Sotirios
name: Zaoutis, Theoklis
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 1
E03829: The Church Calendar of Ioane Zosime, compiled in Georgian in the 10th c., based however on 5th-7th c. prototypes from Palestine, commemorates on 11 August the dedication of the church of *Mary (Mother of Christ, S00033) in the monastery of Spoudaion, *Afra (martyr of Augsburg, S01797), *Myron, (bishop of Crete under Decius, S01798), and 'Elioz', probably *Elianos (martyr of Aman, S00889).
Creators: name: Naleksidze
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: ია. სპოდიონთა მონასტერსა ან(ა)სტასია წ(მიდ)ასა ზემო, ღ(მრ)\თისა მშობლისა ეკლესიასა, სატფური, და აფრას მ(ო)წ(ა)მის(ა)ჲ, და მირონ ეპ(ის)კ(ოპოსი)ს(ა)ჲ, და ელიოზ მ(ო)წ(ა)მის(ა)ჲ.

11 August. In the monastery of Spoudaion, above the Holy Anastasis in the church of the Mother of God, dedication and martyr Afra and bishop Myron and martyr 'Elioz' [=Elianos].

Text: Garitte 1958, 82-87; Electronic text: Gippert 2017, http://titus.uni-frankfurt.de/texte/etcg/cauc/ageo/liturg/iozosca2/iozos.htm (26.12.17); Translation: N. Aleksidze.
BNIP3-mediated mitophagy in macrophages regulates obesity-induced adipose tissue metaflammation
Creators: name: Kim, Sangseob
name: Choi, Cheoljun
name: Son, Yeonho
name: Lee, Junhyuck
name: Joo, Sungug
name: Lee, Yun-Hee
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine

description: Adipose tissue macrophages (ATMs) are key cellular components that respond to nutritional excess, contributing to obesity-induced inflammation and insulin resistance. However, the mechanisms underlying macrophage polarization and recruitment in adipose tissue during obesity remain unclear. In this study, we investigated mitophagy-dependent metabolic reprogramming in ATMs and identified a crucial role of the mitophagy receptor BNIP3 in regulating macrophage polarization in response to obesity. Mitophagic flux in ATMs increased following 12 weeks of high-fat diet (HFD) feeding, with Bnip3 levels upregulated in a HIF1A dependent manner, without affecting other mitophagy receptors. Macrophage-specific bnip3 knockout reduced HFD-induced adipose tissue inflammation and improved glucose tolerance and insulin sensitivity. Mechanistically, hypoxic conditions in vitro induced HIF1A-BNIP3-mediated mitophagy and glycolytic shift in macrophages. Furthermore, HIF1A-BNIP3 signaling-enhanced lipopolysaccharide-induced pro-inflammatory activation in macrophages. These findings demonstrate that BNIP3-mediated mitophagy regulates the glycolytic shift and pro-inflammatory polarization in macrophages and suggest that BNIP3 could be a therapeutical target for obesity-related metabolic diseases. Abbreviation: 2-DG: 2-deoxyglucose; ACADM/MCAD: acyl-CoA dehydrogenase medium chain; ADGRE1/F4/80: adhesion G protein-coupled receptor E1; ATMs: adipose tissue macrophages; BNIP3: BCL2 interacting protein 3; BNIP3L/NIX: BCL2 interacting protein 3 like; CLS: crown-like structure; CoCl2: cobalt(II) chloride; COX4/COXIV: cytochrome c oxidase subunit 4; ECAR: extracellular acidification rate; ECM: extraceullular matrix; gWAT: gonadal white adipose tissue; HFD: high-fat diet; HIF1A/HIF-1 α: hypoxia inducible factor 1 subunit alpha; IL1B/IL-1β: interleukin 1 beta; ITGAM/CD11B: integrin subunit alpha M; KO: knockout; LAMs: lipid-associated macrophages; LPS: lipopolysaccharide; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MRC1/CD206: mannose receptor C-type 1; mtDNA: mitochondrial DNA; NCD: normal chow diet; OCR: oxygen consumption rate; OXPHOS: oxidative phosphorylation; PINK1: PTEN induced kinase 1; PRKN/Parkin: parkin RBR E3 ubiquitin protein ligase; PTPRC/CD45: protein tyrosine phosphatase receptor type C; SVFs: stromal vascular fractions; TEM: transmission electron microscopy; TMRM: tetramethylrhodamine methyl ester; TOMM20: Translocase of outer mitochondrial membrane 20; TREM2: triggering receptor expressed on myeloid cells 2; WT: wild-type
sj-pdf-1-ijm-10.1177_0255761420988923 – Supplemental material for Mapping music education research in Mainland China (2007–2019): A metadata-based literature analysis
Creators: name: Yang, Yang
name: Yin, Aiqing
name: Guan, Tao
Publisher: name: SAGE Journals
Year: 2021
Subjects: Education

description: Supplemental material, sj-pdf-1-ijm-10.1177_0255761420988923 for Mapping music education research in Mainland China (2007–2019): A metadata-based literature analysis by Yang Yang, Aiqing Yin and Tao Guan in International Journal of Music Education
E03830: The Church Calendar of Ioane Zosime, compiled in Georgian in the 10th c., based however on 5th-7th c. prototypes from Palestine, commemorates on 12 August *Aaron (Old Testament prophet, S00596) and *Pantaleon (martyr in Nikomedia, S01427), *Glykerios (deacon and martyr of Nicomedia, S00834), *Hippolytus (martyr of Rome, S00509), *Elianos (martyr of Aman, S00889).
Creators: name: Naleksidze
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: იბ. აჰრონისი და პანტელონისი და ელიანჱსი წ(მიდა)თაჲ, და ულუკერა მ(ო)ამის(ა)ჲ, და ივპ(ოლიტე) მ(ო)წ(ა)მ(ი)ს(ა)ჲ.

12 August. Aaron and Pantaleon and martyr Elianos and martyr 'Ulukera' [=Glykerios] and martyr Hippolytus.

Text: Garitte 1958, 82-87; Electronic text: Gippert 2017, http://titus.uni-frankfurt.de/texte/etcg/cauc/ageo/liturg/iozosca2/iozos.htm (26.12.17); Translation: N. Aleksidze.
sj-pdf-1-jtt-10.1177_1357633X20982737 - Supplemental material for Utilization of telehealth in paediatric genome-wide sequencing: Health services implementation issues in the CAUSES Study
Creators: name: Elliott, Alison M
name: Dragojlovic, Nick
name: Campbell, Teresa
name: Shelin Adam
name: Souich, Christèle Du
name: Fryer, Michele
name: Lehman, Anna
name: Karnebeek, Clara Van
name: Lynd, Larry D
name: Friedman, Jan M
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified

description: Supplemental material, sj-pdf-1-jtt-10.1177_1357633X20982737 for Utilization of telehealth in paediatric genome-wide sequencing: Health services implementation issues in the CAUSES Study by Alison M Elliott Nick Dragojlovic, Teresa Campbell, Shelin Adam, Christèle du Souich, Michele Fryer, Anna Lehman, Clara van Karnebeek, Larry D Lynd and Jan M Friedman in Journal of Telemedicine and Telecare
Additional file 1 of Atherosclerotic plaque features relevant to rupture-risk detected by clinical photon-counting CT ex vivo: a proof-of-concept study
Creators: name: Shami, Annelie
name: Sun, Jiangming
name: Gialeli, Chrysostomi
name: Markstad, Hanna
name: Edsfeldt, Andreas
name: Aurumskjöld, Marie-Louise
name: Gonçalves, Isabel
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Hematology

description: Additional file 1. Supplementary Methods. Supplementary Table S1. Coefficients (b1 for log-transformed energy) of assessed plaque features. Supplementary Table S2. Difference in coefficients (b1 for log-transformed energy) for all comparisons of assessed plaque features. Supplementary Figure S1. Histologically stained plaque sections. Supplementary Figure S2. Hounsfield signatures of the additional plaque features (not in Figure 3) relevant for plaque vulnerability.
EPG-5 regulates TGFB/TGF-β and WNT signalling by modulating retrograde endocytic trafficking
Creators: name: Yuan, Chongzhen
name: Dong, Huachuan
name: Wu, Chunyan
name: Liu, Jinyang
name: Wang, Zheng
name: Wang, Xingwei
name: Ren, Haiyan
name: Wang, Zhaoyu
name: Lu, Qun
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The Vici syndrome protein EPG5 acts as a tethering factor determining the fusion specificity of autophagosomes with late endosomes/lysosomes. Here we demonstrated that during C. elegans development, EPG-5 modulates SMA and MAB TGFB/TGF-β signaling in controlling body size and also WNT signaling in regulating cell migration. EPG-5 is required for retrograde trafficking of the TGFB receptor SMA-6 and WLS/Wntless homolog MIG-14. In epg-5 mutants, SMA-6 and MIG-14 are trapped within hybrid endosomal structures, which colocalize with SNX-1- and SNX-3-labeled vesicles, respectively. Basolateral recycling processes of transmembrane cargos H.s.TFR/hTfR and H.s.IL2RA/hTAC are also defective in epg-5 mutants. Depletion of EPG-5 causes defective RAB-5 and RAB-7, and RAB-5 and RAB-10 conversion, leading to the formation of these hybrid vesicles. The defects in endocytic trafficking and autophagy in epg-5 mutants are ameliorated by knocking down components of the HOPS complex. Our study demonstrates the intersection between the autophagy pathway and the endocytic pathway, providing insights into the pathogenesis of amyotrophic lateral sclerosis (ALS) and Vici syndrome. Abbreviations: ALM: anterior lateral microtubule; ATG: autophagy related; AVM: anterior ventral microtubule; CORVET: class C core vacuole/endosome tethering; DAF-4: abnormal dauer formation 4; DIC: differential interference contrast; EPG: ectopic PGL granules; EPG-5: ectopic P granules 5; GAP: GTPase activating protein; GFP: green fluorescent protein; HOPS: homotypic fusion and vacuole protein sorting; H.s.IL2RA/hTAC: human interleukin 2 receptor subunit alpha; H.s.TFR/hTfR: human transferrin receptor; L1/L4: the first/fourth larval; mCh: mCherry; MIG-14: abnormal cell migration 14; PLM: posterior lateral microtubule; PVM: posterior ventral microtubule; RAB: ras-related protein; RFP: red fluorescent protein; RME-1: receptor mediated endocytosis 1; SMA-6: small 6; SNARE: soluble N-ethylmaleimide-sensitive factor attachment protein receptor; SNX: sorting nexin; TBC-2: TBC1 (Tre-2/Bub2/Cdc16) domain family 2; TGFB/TGF-β: transforming growth factor beta; TGN: trans-Golgi network; VPS: related to yeast vacuolar protein sorting factor; WT: wild type
E03831: The Church Calendar of Ioane Zosime, compiled in Georgian in the 10th c., based however on 5th-7th c. prototypes from Palestine, prescribes on 13 August synaxis at the church of *Mary (Mother of Christ, S 00033), and commemorates *Aeglon (anchorite in Sketis, S01514) and *Maximos (the Confessor, ob. 662, S01455).
Creators: name: Naleksidze
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: იგ. ბეთლემისა გზასა, სამსა მილიონსა, ბეტოფორის დაბასა, კათისმას, ღ(მრთ)ისმშ(ო)ბლისა ეკლესიასა, კრებ(ა)ჲ, ს(ა)ტფ(უ)\რი და ს(ა)ტფ(უ)რი, და ეჯლონე მ(ო)ნ(ა)ზ(ო)ნის(ა)ჲ სკ(ი)ტელი\ს(ა)ჲ, და მაქსიმე მ(ო)წ(ა)მ(ი)ს(ა)ჲ -

13 August. On the third mile on the road to Bethlehem in the village Bethrono, in Kathisma, synaxis in the church of the Mother of God and dedication, and Aeglon monk of Sketis and Maximos the martyr,

Text: Garitte 1958, 82-87; Electronic text: Gippert 2017, http://titus.uni-frankfurt.de/texte/etcg/cauc/ageo/liturg/iozosca2/iozos.htm (26.12.17); Translation: N. Aleksidze.
Table S1 - Supplemental material for Studies on the Mechanism of Gegen Qinlian Decoction in Treating Diabetes Mellitus Based on Network Pharmacology
Creators: name: Xiaodong Deng
name: Yuhua Liang
name: Jianmei Hu
name: Yuhui Yang
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, Table S1, for Studies on the Mechanism of Gegen Qinlian Decoction in Treating Diabetes Mellitus Based on Network Pharmacology by Xiaodong Deng, Yuhua Liang, Jianmei Hu and Yuhui Yang in Natural Product Communications
Mycobacterium bovis Mb3523c protein regulates host ferroptosis via chaperone-mediated autophagy
Creators: name: Wang, Haoran
name: Liu, Dingpu
name: Ge, Xin
name: Wang, Yuanzhi
name: Zhou, Xiangmei
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: The occurrence of necrosis during Mycobacterium bovis (M. bovis) infection is regarded as harmful to the host because it promotes the spread of M. bovis. Ferroptosis is a controlled type of cell death that occurs when there is an excessive buildup of both free iron and harmful lipid peroxides. Here, we demonstrate that the mammalian cell entry (Mce) 4 family protein Mb3523c triggers ferroptosis to promote M. bovis pathogenicity and dissemination. Mechanistically, Mb3523c, through its Y237 and G241 site, interacts with host HSP90 protein to stabilize the LAMP2A on the lysosome to promote the chaperone-mediated autophagy (CMA) pathway. Then, GPX4 is delivered to lysosomes for destruction via the CMA pathway, eventually inducing ferroptosis to promote M. bovis transmission. In summary, our findings offer novel insights into the molecular mechanisms of pathogen-induced ferroptosis, demonstrating that targeting the GPX4-dependent ferroptosis through blocking the M. bovis Mb3523c-host HSP90 interface represents a potential therapeutic strategy for tuberculosis (TB). Abbreviations: CFU: colony-forming units; CMA: chaperone-mediated autophagy; Co-IP: co-immunoprecipitation; Fer-1: ferrostatin-1; GPX4: glutathione peroxidase 4; HSP90: heat shock protein 90; LDH: lactate dehydrogenase; Mce: mammalian cell entry; MOI: multiplicity of infection; Nec-1: necrostatin-1; PI: propidium iodide; RCD: regulated cell death.
Additional file 1 of Comparison of 18F-FDG PET and arterial spin labeling MRI in evaluating Alzheimer’s disease and amnestic mild cognitive impairment using integrated PET/MR
Creators: name: Bi, Sheng
name: Yan, Shaozhen
name: Chen, Zhigeng
name: Cui, Bixiao
name: Shan, Yi
name: Yang, Hongwei
name: Qi, Zhigang
name: Zhao, Zhilian
name: Han, Ying
name: Lu, Jie
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Cell Biology
Molecular Biology
Neuroscience
Cancer
Mental Health
Hematology

description: Additional file 1: Absolute CBF, rCBF with pons as reference, and F-FDG PET SUVR with PVC data analysis results.
E03832: The Church Calendar of Ioane Zosime, compiled in Georgian in the 10th c., based however on 5th-7th c. prototypes from Palestine, prescribes on 14 August synaxis for *Mary (Mother of Christ, S00033) and commemorates *Aeglon (anchorite in Sketis, S01514), and *Dometios (monk and martyr of Syria under Julian, S00414), and *Elianos (martyr of Aman, S00889).
Creators: name: Bryan
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: იდ. ბეთოროს დაბასა, კრ(ე)ბ(ა)ჲ ღ(მრთ)ისმშ(ო)ბლისათჳს, და ჴსენებ(ა)ჲ ნეტარისა ეგლონისი სკიტელის(ა)ჲ, და წ(მიდ)ისა დომენ\ტისი, და ელიანოს მ(ო)წ(ა)მის(ა)ჲ :.:..

14 August. In village Bethoron, synaxis for the Mother of God and commemoration of blessed Aeglon of Skitis, and saint Dometios and martyr Elianos.

Text: Garitte 1958, 82-87; Electronic text: Gippert 2017, http://titus.uni-frankfurt.de/texte/etcg/cauc/ageo/liturg/iozosca2/iozos.htm (26.12.17); Translation: N. Aleksidze.
EPG-5 regulates tgfb/tgf-β and WNT signaling by modulating retrograde endocytic trafficking
Creators: name: Yuan, Chongzhen
name: Dong, Huachuan
name: Wu, Chunyan
name: Liu, Jinyang
name: Wang, Zheng
name: Wang, Xingwei
name: Ren, Haiyan
name: Wang, Zhaoyu
name: Lu, Qun
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The Vici syndrome protein EPG5 acts as a tethering factor determining the fusion specificity of autophagosomes with late endosomes/lysosomes. Here we demonstrated that during C. elegans development, EPG-5 modulates SMA and MAB TGFB/TGF-β signaling in controlling body size and also WNT signaling in regulating cell migration. EPG-5 is required for retrograde trafficking of the TGFB receptor SMA-6 and WLS/Wntless homolog MIG-14. In epg-5 mutants, SMA-6 and MIG-14 are trapped within hybrid endosomal structures, which colocalize with SNX-1- and SNX-3-labeled vesicles, respectively. Basolateral recycling processes of transmembrane cargos H.s.TFR/hTfR and H.s.IL2RA/hTAC are also defective in epg-5 mutants. Depletion of EPG-5 causes defective RAB-5 and RAB-7, and RAB-5 and RAB-10 conversion, leading to the formation of these hybrid vesicles. The defects in endocytic trafficking and autophagy in epg-5 mutants are ameliorated by knocking down components of the HOPS complex. Our study demonstrates the intersection between the autophagy pathway and the endocytic pathway, providing insights into the pathogenesis of amyotrophic lateral sclerosis (ALS) and Vici syndrome.
E03833: The Church Calendar of Ioane Zosime, compiled in Georgian in the 10th c., based however on 5th-7th c. prototypes from Palestine, celebrates on 15 August the feast of *Mary (Mother of Christ, S00033) and commemorates *Georgios (possibly monk at Chozeba monastery in Palestine, 6th c.-7th c., S01522) and *Gerontios (possibly martyr in Carthage under Decius, S01432).
Creators: name: Naleksidze
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: იე. მარიამობაჲ*, და წ(მიდ)ისა გ(იორგ)ისი მონაზოსაჲ სალო\სისაჲ, და წ(მიდ)ისა გერონტისი.

15 August. Feast of Mary, and holy ascetic monk Georgios and saint Gerontios.

Text: Garitte 1958, 82-87; Electronic text: Gippert 2017, http://titus.uni-frankfurt.de/texte/etcg/cauc/ageo/liturg/iozosca2/iozos.htm (26.12.17); Translation: N. Aleksidze.
ESCRT III-mediated lysosomal repair improve renal tubular cell injury in cisplatin-induced AKI
Creators: name: Tian, Zhangyu
name: Wu, Yiming
name: Yi, Bin
name: Li, Ling
name: Liu, Yan
name: Zhang, Hao
name: Li, Aimei
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer

description: The chemotherapeutic agent cisplatin is widely utilized for the treatment of various solid tumors. However, its clinical utility is limited by nephrotoxicity. Although numerous studies have demonstrated the potential of enhancing macroautophagy/autophagy in alleviating cisplatin-induced acute kidney injury (AKI), the dynamics of the autophagic process during renal tubular injury remain to be elucidated. In our investigation, we observed that cisplatin treatment leads to increased expression of LC3-II, GABARAPL1, SQSTM1/p62 and NBR1 in mouse renal tubular epithelial cells and BUMPT cells. Moreover, ultrastructurally, there is extensive accumulation of autophagic vacuoles in AKI mice. These findings imply that cisplatin-induced AKI results in impaired autophagic flow within renal tubular cells. Furthermore, LGALS3 (galectin 3) was found to be enriched in lysosomes after cisplatin treatment, revealing a close association between autophagy dysfunction and impaired lysosomal membrane integrity. Given the damaging contents of lysosomes, lysosomal membrane permeabilization must be rapidly resolved. Our findings showed that ESCRT III subunit CHMP4A-mediated lysosomal membrane repair significantly ameliorates autophagic defects and protects against lysosomal damage-induced cell death in a cisplatin-induced AKI model. In conclusion, our study indicates that ESCRT III-mediated lysosomal repair can relieve cisplatin-induced cell apoptosis and restore normal autophagy function in renal tubular epithelial cells. This mechanism plays a protective role against cisplatin-induced AKI. Abbreviations: AAV: adeno-associated virus; AKI: acute kidney injury; CQ: chloroquine; ESCRT: endosomal sorting complex required for transport; LMP: lysosomal membrane permeabilization; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MTOR: mechanistic target of rapamycin kinase; PAS: periodic acid Schiff; PTECs: proximal renal tubule epithelial cells; TEM: transmission electron microscopy; TUNEL: terminal deoxynucleotidyl transferase dUTP nick end labeling.
A Poster For "Teaching Programming With Flipped Classroom Method: A Study From Two Programming Courses"
Creators: name: Herala, Antti
name: Vanhala, Erno
name: Knutas, Antti
name: Ikonen, Jouni
Publisher: name: Zenodo
Year: 2015

description: The poster from the poster presentation of the following paper:

Antti Herala, Erno Vanhala, Antti Knutas, and Jouni Ikonen. 2015. Teaching programming with flipped classroom method: a study from two programming courses. In Proceedings of the 15th Koli Calling Conference on Computing Education Research (Koli Calling '15). ACM, New York, NY, USA, 165-166. DOI: http://dx.doi.org/10.1145/2828959.2828983

See the short paper at ACM Digital Library at http://dl.acm.org/citation.cfm?id=2828983 .
Sprache, Macht und Soziale Arbeit
Langue, pouvoir et travail social
Creators: name: Bühler, Judith
name: Girschik, Katja
Publisher: name: AvenirSocial
Year: 2024
Subjects: Soziale Arbeit
Travail social
Sprache
Langue
Macht
Pouvoir
361: Sozialarbeit und Sozialhilfe
400: Sprache und Linguistik

description: Soziale Arbeit besteht grossteils aus Interaktion mit Adressat*innen, anderen Sozialarbeitenden und Akteur*innen aus Gesellschaft und Politik. Dazu bedienen sich Sozialarbeitende hauptsächlich sprachlicher Mittel. Sprache ist ein essenzielles Arbeitsinstrument für die Soziale Arbeit und verdient besondere Aufmerksamkeit.

Le travail social se fonde en grande partie sur les échanges entre les destinataires, les autres travailleur·euse·s sociaux·ales et acteur·ice·s de la société et de la politique. Ces échanges passent en grande partie par les mots, et donc la langue.
Additional file 1 of How gender and low mental health literacy are related to unmet need for mental healthcare: a cross-sectional population-based study in Sweden
Creators: name: Blom, Sara
name: Lindh, Frida
name: Lundin, Andreas
name: Burström, Bo
name: Hensing, Gunnel
name: Löve, Jesper
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Science Policy
Mental Health

description: Supplementary Material 1. File name: Additional file 1.pdf. Title of data: Additional file 1. Supplementary table. Description of data: Sensitivity analyses among those that had current poor mental health.
E03834: The Church Calendar of Ioane Zosime, compiled in Georgian in the 10th c., based however on 5th-7th c. prototypes from Palestine, celebrates on 16 August the assumption of *Mary (Mother of Christ, S00033) and commemorates *Makarios (Bishop of Jerusalem, S01428).
Creators: name: Naleksidze
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: ივ. ამაღლებაჲ ღმრთისმშობლისაჲ ნი[აწმიდას]. და ჴსენებაჲ მაკარი ერუსალჱმელისაჲ.

16 August. The assumption of the Mother of God and commemoration of Makarios of Jerusalem.

Text: Garitte 1958, 82-87; Electronic text: Gippert 2017, http://titus.uni-frankfurt.de/texte/etcg/cauc/ageo/liturg/iozosca2/iozos.htm (26.12.17); Translation: N. Aleksidze.
sj-pdf-3-aei-10.1177_1534508420984522 – Supplemental material for Investigating the Psychometric Properties of the Social-Emotional Learning Scale
Creators: name: Thomas, Christopher L.
name: Zolkoski, Staci M.
name: Sass, Sarah M.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, sj-pdf-3-aei-10.1177_1534508420984522 for Investigating the Psychometric Properties of the Social-Emotional Learning Scale by Christopher L. Thomas, Staci M. Zolkoski and Sarah M. Sass in Assessment for Effective Intervention
ESCRT iii-mediated lysosomal repair improve renal tubular cell injury in cisplatin-induced AKI
Creators: name: Tian, Zhangyu
name: Wu, Yiming
name: Yi, Bin
name: Li, Ling
name: Liu, Yan
name: Zhang, Hao
name: Li, Aimei
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer

description: The chemotherapeutic agent cisplatin is widely utilized for the treatment of various solid tumors. However, its clinical utility is limited by nephrotoxicity. Although numerous studies have demonstrated the potential of enhancing macroautophagy/autophagy in alleviating cisplatin-induced acute kidney injury (AKI), the dynamics of the autophagic process during renal tubular injury remain to be elucidated. In our investigation, we observed that cisplatin treatment leads to increased expression of LC3-II, GABARAPL1, SQSTM1/p62 and NBR1 in mouse renal tubular epithelial cells and BUMPT cells. Moreover, ultrastructurally, there is extensive accumulation of autophagic vacuoles in AKI mice. These findings imply that cisplatin-induced AKI results in impaired autophagic flow within renal tubular cells. Furthermore, LGALS3 (galectin 3) was found to be enriched in lysosomes after cisplatin treatment, revealing a close association between autophagy dysfunction and impaired lysosomal membrane integrity. Given the damaging contents of lysosomes, lysosomal membrane permeabilization must be rapidly resolved. Our findings showed that ESCRT III subunit CHMP4A-mediated lysosomal membrane repair significantly ameliorates autophagic defects and protects against lysosomal damage-induced cell death in a cisplatin-induced AKI model. In conclusion, our study indicates that ESCRT III-mediated lysosomal repair can relieve cisplatin-induced cell apoptosis and restore normal autophagy function in renal tubular epithelial cells. This mechanism plays a protective role against cisplatin-induced AKI.
Additional file 2 of How gender and low mental health literacy are related to unmet need for mental healthcare: a cross-sectional population-based study in Sweden
Creators: name: Blom, Sara
name: Lindh, Frida
name: Lundin, Andreas
name: Burström, Bo
name: Hensing, Gunnel
name: Löve, Jesper
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Science Policy
Mental Health

description: Supplementary Material 2. File name: Additional file 2.pdf. Title of data: Additional file 2. Supplementary table. Description of data: Sensitivity analyses using the median as the cut-off for low mental health literacy.
E03835: The Church Calendar of Ioane Zosime, compiled in Georgian in the 10th c., based however on 5th-7th c. prototypes from Palestine, commemorates on 17 August in the building of Priest Sabinos *Andrew (the Apostle, S00288), *Mary (Mother of Christ, S00033), *Paulos and Iouliana/Juliana, martyrs in Ptolemais, ob. 270, S01535).
Creators: name: Naleksidze
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: იზ. პ(ე)ტრე მ(ო)ც(ი)ქ(უ)ლისა ეკლ(ე)სიასა, სატფ(უ)რი, სადა იგი იყო ტაძარი კაიაფაჲსი, და ღ(მრ)თისმშ(ო)ბ(ლ)ის(ა)ჲვე ნია წ(მიდა)ს და პ(ა)ვლე და იოვ(ა)ნ(ე)სი მ(ო)წ(ა)მ(ე)თ(ა)ჲ, და ნეა წ(მიდ)ისა სატფ(უ)რი.

17 August. The dedication of the church of Apostle Peter, where there was the house of Caiaphas and of the Mother of God in Holy Nea and martyrs Paulos and Ioulianna and the dedication of Holy Nea.

Text: Garitte 1958, 82-87; Electronic text: Gippert 2017, http://titus.uni-frankfurt.de/texte/etcg/cauc/ageo/liturg/iozosca2/iozos.htm (26.12.17); Translation: N. Aleksidze.
E03836: The Church Calendar of Ioane Zosime, compiled in Georgian in the 10th c., based however on 5th-7th c. prototypes from Palestine, commemorates on 18 August *Andrew (the Apostle, S00288), *Agathonikos (martyr of Bithynia and Thrace, S01628), *Floros (martyr of Ulpiana, S00871).
Creators: name: Bryan
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: იჱ. ანდრეა მ(ო)ც(ი)ქ(უ)ლის(ა)ჲ და ზაბინოს ხუცის(ა)ჲ, და აგათონიკოს მ(ო)წ(ა)მ(ი)საჲ, და ფლორონ მოწამისაჲ.

18 August. Apostle Andrew and presbyter Sabinus and martyr Agathonikos and martyr Floros.

Text: Garitte 1958, 82-87; Electronic text: Gippert 2017, http://titus.uni-frankfurt.de/texte/etcg/cauc/ageo/liturg/iozosca2/iozos.htm (26.12.17); Translation: N. Aleksidze.
Additional file 3 of How gender and low mental health literacy are related to unmet need for mental healthcare: a cross-sectional population-based study in Sweden
Creators: name: Blom, Sara
name: Lindh, Frida
name: Lundin, Andreas
name: Burström, Bo
name: Hensing, Gunnel
name: Löve, Jesper
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Science Policy
Mental Health

description: Supplementary Material 3. File name: Additional file 3.pdf. Title of data: Additional file 3. Supplementary table. Description of data: Sensitivity analyses using MAKS item 1–5, excluding item 6.
R406 and its structural analogs reduce SNCA/α-synuclein levels via autophagic degradation
Creators: name: Zhong, Chao
name: Gao, Xiaoge
name: Chen, Qi
name: Guan, Bowen
name: Wu, Wanli
name: Ma, Zhiqiang
name: Tao, Mengdan
name: Liu, Xihuan
name: Ding, Yu
name: Fei, Yiyan
name: Liu, Yan
name: Lu, Boxun
name: Li, Zhaoyang
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biological Sciences not elsewhere classified

description: The presence of neuronal Lewy bodies mainly composed of SNCA/α-synuclein aggregations is a pathological feature of Parkinson disease (PD), whereas reducing SNCA protein levels may slow the progression of this disease. We hypothesized that compounds enhancing SNCA’s interaction with MAP1LC3/LC3 May increase its macroautophagic/autophagic degradation. Here, we conducted small molecule microarray (SMM)-based screening to identify such compounds and revealed that the compound R406 could decrease SNCA protein levels in an autophagy-dependent manner. We further validated the proposed mechanism, in which knockdown of essential gene ATG5 for autophagy formation and using the autophagy inhibitor chloroquine (CQ) blocked the effect of R406. Additionally, R406 also reduced the levels of phosphorylated serine 129 of SNCA (p-S129-SNCA) in SNCA preformed fibrils (PFFs)-induced cellular models and rescued neuron degeneration. Importantly, we confirmed that R406 could alleviate PD-relevant disease phenotypes in human SNCA PFFs-induced cellular models and PD patient-derived organoid models. Taken together, we demonstrated the possibility of lowering SNCA levels by enhancing its autophagic degradation by compounds increasing SNCA-LC3 interactions. Abbreviations: ATTEC: autophagy-tethering compounds; BafA1: bafilomycin A1; BiFC: bimolecular fluorescence complementation; CQ: chloroquine; hMOs: human midbrain organoids; iPSC: induced pluripotent stem cells; MBP: maltose-binding protein; mHTT: mutant huntingtin; OI-RD: oblique-incidence reflectivity difference; PFFs: preformed fibrils; p-S129-SNCA: phosphorylated serine 129 of SNCA; PD: Parkinson disease; ROS: reactive oxygen species; siRNA: small interfering RNA; SMM: small molecule microarray; SNCA: synuclein alpha; SYK: spleen associated tyrosine kinase.
E03837: The Church Calendar of Ioane Zosime, compiled in Georgian in the 10th c., based however on 5th-7th c. prototypes from Palestine, commemorates on 19 August *Paul (the Apostle, S00008) and *Andreas Stratelates (martyr under Maximianus in early 4th c., S00763).
Creators: name: Dlambert
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: ით. ჰრომინჱს შჱნებულსა ჴსენებაჲ პავლე მოციქულისაჲ და ანდრია მჴედრისაჲ:

19 August. In the building of the Romans, commemoration of Apostle Paul and Andreas Stratelates.

Text: Garitte 1958, 82-87; Electronic text: Gippert 2017, http://titus.uni-frankfurt.de/texte/etcg/cauc/ageo/liturg/iozosca2/iozos.htm (26.12.17); Translation: N. Aleksidze.
Additional file 1 of Effect of adjuvant chemotherapy on the oncological outcome of rectal cancer patients with pathological complete response
Creators: name: Yang, Jianguo
name: Deng, Qican
name: Cheng, Yong
name: Fu, Zhongxue
name: Wu, Xin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Additional file 1: Figure S1. The funnel plot for publication bias. A. Overall survival; B. Disease-free survival; C. Recurrence-free survival, Table S1. The NOS score of included studies, Table S2. PRISMA 2020 Checklist, Table S3. The strategy of literature search.