cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Core amino acid substitutions in HCV-3a isolates from Pakistan and opportunities for multi-epitopic vaccines
Creators: name: Khan, Ayyaz
name: Nawaz, Mehboob
name: Ullah, Saeed
name: Rehman, Irshad Ur
name: Khan, Abbas
name: Saleem, Shoaib
name: Zaman, Nasib
name: Shinwari, Zabta Khan
name: Ali, Muhammad
name: Wei, Dong-Qing
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Hepatitis C virus (HCV), which infected 71 million worldwide and about 5%–6% are from Pakistan, is an ssRNA virus, responsible for end‐stage liver disease. To date, no effective therapy is available to cure this disease. Hence, it is important to study the most prevalent genotypes infecting human population and design novel vaccine or small molecule inhibitors to control the infections associated with HCV. Therefore, in this study clinical samples (n = 35; HCV-3a) from HCV patients were subjected to Sanger sequencing method. The sequencing of the core gene, which is generally considered as conserved, involved in the detection, quantitation and genotyping of HCV was performed. Multiple mutations, that is, R46C, R70Q, L91C, G60E, N/S105A, P108A, N110I, S116V, G90S, A77G and G145R that could be linked with response to antiviral therapies were detected. Phylogenetic analysis suggests emerging viral isolates are circulating in Pakistan. Using ab initio modelling technique, we predicted the 3D structure of core protein and subjected to molecular dynamics simulation to extract the most stable conformation of the structure for further analysis. Immunoinformatic approaches were used to propose a multi-epitopes vaccine against HCV by using core protein. The vaccine constructs consist of nine CTL and three HTL epitopes joined by different linkers were docked against the two reported Toll-like receptors (TLR-3 and TLR-8). Docking of vaccine construct with TLR-3 and TLR-8 shows proper binding and in silico expression of the vaccine resulted in a CAI value of 0.93. These analyses suggest that specific immune responses may be produced by the proposed vaccine. Communicated by Ramaswamy H. Sarma
title: DTI and 1H-MRS in patients after brain ischemic stroke: Preliminary results
Creators: name: Kubas, Bożena
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Neuroradiology brain
subject: Ischaemia / Infarction
subject: Neuro - Stroke

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: We assessed the diagnostic role of DTI and 1H-MRS in the detection of abnormalities in diffusion anisotropy and cerebral metabolites levels in CST after cortical/subcortical infarction. The extent of Wallerian degeneration was compared with the...
Lamparia pratensis Shear & Marek 2022
Creators: name: Shear, William A.
name: Marek, Paul E.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Chordeumatida
Striariidae
Lamparia
Lamparia pratensis

description: Lamparia pratensis Shear & Marek, 2022
Lamparia pratensis Shear & Marek, 2022b, Zootaxa 5205: 514. Male holotype from Grassy Flat Campground, near Gasquet, Del Norte Co., California (FMNH). Known only from the type locality.
description: Published as part of Shear, William A. & Marek, Paul E., 2024, The millipede family Striariidae Bollman, 1893. IX. The identity of Striaria californica Cook, 1899, and the new genus Bayaria for Striaria nana Loomis, 1936, with a key to genera and an annotated checklist of the Striariidae (Diplopoda, Chordeumatida, Striarioidea), pp. 524-544 in Zootaxa 5463 (4) on page 537, DOI: 10.11646/zootaxa.5463.4.4, http://zenodo.org/record/11612167
Maraplia Shear & Marek 2022
Creators: name: Shear, William A.
name: Marek, Paul E.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Chordeumatida
Striariidae
Maraplia

description: Genus Maraplia Shear & Marek 2022
Maraplia Shear & Marek, 2022b, Zootaxa 5205: 506.
Type species, Maraplia napa Shear & Marek, 2022, by original designation. Three species.
description: Published as part of Shear, William A. & Marek, Paul E., 2024, The millipede family Striariidae Bollman, 1893. IX. The identity of Striaria californica Cook, 1899, and the new genus Bayaria for Striaria nana Loomis, 1936, with a key to genera and an annotated checklist of the Striariidae (Diplopoda, Chordeumatida, Striarioidea), pp. 524-544 in Zootaxa 5463 (4) on page 537, DOI: 10.11646/zootaxa.5463.4.4, http://zenodo.org/record/11612167
Sonnenfleckenzeichnung Nr. 146.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 01.07.1975, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
Maraplia chico Shear & Marek 2022
Creators: name: Shear, William A.
name: Marek, Paul E.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Chordeumatida
Striariidae
Maraplia
Maraplia chico

description: Maraplia chico Shear & Marek, 2022
Maraplia chico Shear & Marek, 2022b, Zootaxa 5205: 509. Male holotype from West Branch of the Feather River, Butte Co., California (FMNH). Known from two localities near Chico, Butte Co., California.
description: Published as part of Shear, William A. & Marek, Paul E., 2024, The millipede family Striariidae Bollman, 1893. IX. The identity of Striaria californica Cook, 1899, and the new genus Bayaria for Striaria nana Loomis, 1936, with a key to genera and an annotated checklist of the Striariidae (Diplopoda, Chordeumatida, Striarioidea), pp. 524-544 in Zootaxa 5463 (4) on page 537, DOI: 10.11646/zootaxa.5463.4.4, http://zenodo.org/record/11612167
title: Color-coded nonenhanced head CT in acute stroke
Creators: name: Starzinger, Mathias
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Neuroradiology brain
subject: Ischaemia / Infarction
subject: Neuro - Stroke

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: It has been shown that using variable window width and center level settings facilitates the detection of ischemic brain parenchyma in nonenhanced CT of the head by accentuating the contrast between normal and edematous tissue. The aim of this study...
Sonnenfleckenzeichnung Nr. 271.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.11.1975, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
title: Brain CT perfusion: Think beyond acute ischemia
Creators: name: Mahajan, Abhishek
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Neuroradiology brain
subject: Ischaemia / Infarction
subject: Neuro - Stroke

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: To show CT perfusion applications in CNS infections providing complimentary information especially useful for emergent diagnosis. To describe specific perfusion CT findings of tumoral and nontumoral...
The comparative analysis of the properties and structures of purine nucleoside phosphorylases from thermophilic bacterium Thermus thermophilus HB27
Creators: name: Timofeev, Vladimir I.
name: Fateev, Ilya V.
name: Kostromina, Maria A.
name: Abramchik, Yuliya A.
name: Konstantinova, Irina D.
name: Volkov, Vladimir V.
name: Lykoshin, Dmitry D.
name: Mikheeva, Olga O.
name: Muravieva, Tatiana I.
name: Esipov, Roman S.
name: Kuranova, Inna P.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Two recombinant purine nucleoside phosphorylases from thermophilic bacterium Thermus thermophilus HB27 encoded by genes TT_C1070 (TthPNPI) and TT_C0194 (TthPNPII) were purified and characterized. The comparative analysis of their sequences, molecular weight, enzymes specificity and kinetics of the catalyzed reaction were realized. As a result, it was determined that the TthPNPI is specific to guanosine while the TthPNPII to adenosine. According to the results of the size exclusion chromatography and SAXS study both enzymes are hexameric molecules. Based on the sequence alignment with homologous purine nucleoside phosphorylases (PNPs), Asn was identified as a purine base recognizing residue in the active site of TthPNPI and Asp in TthPNPII. The three-dimensional structure of TthPNPII was solved at 2.5 Å resolution by molecular replacement method using crystals grown in microgravity. Position of phosphate in the active site cavity is located. The possible arrangement of adenosine and guanosine in TthPNPII active site cavity is considered using superposition with the structures of homologous trimeric and hexameric PNPs complexed with corresponding substrates. The peculiarities of oligomeric structure of TthPNPII in comparison with homologous PNPs are described. It is shown that two trimeric molecules of TthPNPII in the asymmetric part of the unit cell are connected by three two-fold axis into a hexamer with 32-point symmetry. This type of hexameric structure of PNP is found for the first time. The interface area between the subunits in trimeric molecule and between the trimers in TthPNPII hexamer is described. Communicated by Ramaswamy H. Sarma.
Sonnenfleckenzeichnung Nr. 158.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 14.07.1975, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
Maraplia napa Shear & Marek 2022
Creators: name: Shear, William A.
name: Marek, Paul E.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Chordeumatida
Striariidae
Maraplia
Maraplia napa

description: Maraplia napa Shear & Marek, 2022
Maraplia napa Shear & Marek, 2022b, Zootaxa 5205: 507. Male holotype and female paratypes from 1 mile south of Oakville, Napa Co., California (FMNH). Also known from a single locality in Lake Co., California.
description: Published as part of Shear, William A. & Marek, Paul E., 2024, The millipede family Striariidae Bollman, 1893. IX. The identity of Striaria californica Cook, 1899, and the new genus Bayaria for Striaria nana Loomis, 1936, with a key to genera and an annotated checklist of the Striariidae (Diplopoda, Chordeumatida, Striarioidea), pp. 524-544 in Zootaxa 5463 (4) on page 537, DOI: 10.11646/zootaxa.5463.4.4, http://zenodo.org/record/11612167
Sonnenfleckenzeichnung Nr. 251.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.10.1975, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
Sonnenfleckenzeichnung Nr. 120.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.06.1975, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
Core amino acid substitutions in HCV-3a isolates from Pakistan and opportunities for multi-epitopic vaccines
Creators: name: Khan, Ayyaz
name: Nawaz, Mehboob
name: Ullah, Saeed
name: Rehman, Irshad Ur
name: Khan, Abbas
name: Saleem, Shoaib
name: Zaman, Nasib
name: Shinwari, Zabta Khan
name: Ali, Muhammad
name: Wei, Dong-Qing
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Hepatitis C virus (HCV), which infected 71 million worldwide and about 5%–6% are from Pakistan, is an ssRNA virus, responsible for end‐stage liver disease. To date, no effective therapy is available to cure this disease. Hence, it is important to study the most prevalent genotypes infecting human population and design novel vaccine or small molecule inhibitors to control the infections associated with HCV. Therefore, in this study clinical samples (n = 35; HCV-3a) from HCV patients were subjected to Sanger sequencing method. The sequencing of the core gene, which is generally considered as conserved, involved in the detection, quantitation and genotyping of HCV was performed. Multiple mutations, that is, R46C, R70Q, L91C, G60E, N/S105A, P108A, N110I, S116V, G90S, A77G and G145R that could be linked with response to antiviral therapies were detected. Phylogenetic analysis suggests emerging viral isolates are circulating in Pakistan. Using ab initio modelling technique, we predicted the 3D structure of core protein and subjected to molecular dynamics simulation to extract the most stable conformation of the structure for further analysis. Immunoinformatic approaches were used to propose a multi-epitopes vaccine against HCV by using core protein. The vaccine constructs consist of nine CTL and three HTL epitopes joined by different linkers were docked against the two reported Toll-like receptors (TLR-3 and TLR-8). Docking of vaccine construct with TLR-3 and TLR-8 shows proper binding and in silico expression of the vaccine resulted in a CAI value of 0.93. These analyses suggest that specific immune responses may be produced by the proposed vaccine. Communicated by Ramaswamy H. Sarma
title: Diffusion weighted imaging in acute stroke: How many b-values are necessary?
Creators: name: Langner, Soenke
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Neuroradiology brain
subject: Ischaemia / Infarction
subject: Neuro - Stroke

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Diffusion-weighted MRI (DWI) is an important imaging modality in stroke imaging. Apparent diffusion coefficient (ADC) maps can be calculated to quantify the diffusion of water within the tissue. ADC values are calculated within a set of MR signal...
title: Intracranial carotid calcifications in Scandinavian stroke patients
Creators: name: Christensen, Anders
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Neuroradiology brain
subject: Ischaemia / Infarction
subject: Neuro - Stroke

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Calcifications of the intracranial carotid artery (ICCA) demonstrated on CT scans have recently been associated with risk of stroke. ICCA is age-related, more frequent in patients with ischemic stroke, and correlates with intracranial...
Logopädie für Kinder mit einer Autismus-Spektrum-Störung und einer frühkindlichen Essstörung. Eine Zusammenstellung von theoretischen Grundlagen und praktischem Wissen für die Ableitung einer logopädischen Therapie für Kinder im Frühbereich mit ASS und einer frühkindlichen Essstörung mit dem Leitsymptom selektives Essverhalten bei Besonderheiten der sensorischen Verarbeitung
Creators: name: Hottarek, Tatjana
Publisher: name: Interkantonale Hochschule für Heilpädagogik
Year: 2024
Subjects: Logopädie
Bachelorarbeit
Autismus-Spektrum-Störung
Essstörung
Kind
Therapie

description: Frühkindliche Essstörungen sind bei Kindern mit einer Autismus-Spektrum-Störung (ASS) sehr häufig und zeigen sich überwiegend mit dem Leitsymptom selektives Essverhalten, was mit Besonderheiten der sensorischen Verarbeitung assoziiert wird. Selektives Essverhalten geht mit einer hohen Belastung des Kindes und dessen Umfeld einher und kann weitreichende Folgen mit sich bringen. Dennoch gibt es wenig logopädische Therapieansätze und Forschungsliteratur dazu. Die vorliegende Arbeit hat daher zum Ziel, sich mit logopädischen Therapiemöglichkeiten für Kinder im Frühbereich mit ASS und einer frühkindlichen Essstörung mit dem Leitsymptom selektives Essverhalten bei Besonderheiten der sensorischen Verarbeitung auseinanderzusetzen und Empfehlungen für die therapeutische Praxis abzuleiten. Dafür wurde eine Recherche an ausgewählten Hochschulen der Logopädie, Ergotherapie und Psychologie sowie Weiterbildungsstätten und behandelnden Institutionen durchgeführt, aktuelle Diagnostik- und Therapieprogramme aus der Literatur entnommen und das Wissen aus der logopädischen Praxis mithilfe einer Onlineumfrage miteinbezogen. Aus dem zusammengetragenen Wissen kann abgeleitet werden, dass sich die logopädische Therapie idealerweise aus den Bereichen Elternarbeit, Arbeit an oralmotorischen und oralsensorischen Fähigkeiten, Festlegen von Essensregeln, Desensibilisierung der oralen Hypersensibilität, Einführen neuer Nahrungsmittel und Abbau von Ängsten bezüglich des Essens zusammensetzt und sich handlungs- und spielorientierte Methoden zusammen mit dem Einsatz von unterstützter Kommunikation bewährt haben. Zudem ergibt sich eine Forderung nach mehr deutschsprachigen Forschungsbeiträgen, Diagnostik- und Therapieansätzen sowie einem höheren Stellenwert der Thematik in Aus- und Weiterbildungsangeboten.
Sonnenfleckenzeichnung Nr. 99.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 12.05.1975, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
title: Prediction of a large diffusion/perfusion mismatch by the presence of a small diffusion abnormality in the setting of a distal ICA or proximal MCA occlusion
Creators: name: Gonzalez, Ramon
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Neuroradiology brain
subject: Ischaemia / Infarction
subject: Neuro - Stroke

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Diffusion and perfusion MR imaging is increasingly being used to assess acute ischemic stroke patients, and to select patients for thrombolytic therapy outside of the traditional time windows. The rationale is that the diffusion abnormality closely...
Maraplia schusteri Shear & Marek 2022
Creators: name: Shear, William A.
name: Marek, Paul E.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Chordeumatida
Striariidae
Maraplia
Maraplia schusteri

description: Maraplia schusteri Shear & Marek, 2022
Maraplia schusteri Shear & Marek, 2022b, Zootaxa 5205: 509. Male holotype and male paratypes from near Stringtown Hill northeast of Oroville, Butte Co., California (FSCA). Known only from the type locality.
description: Published as part of Shear, William A. & Marek, Paul E., 2024, The millipede family Striariidae Bollman, 1893. IX. The identity of Striaria californica Cook, 1899, and the new genus Bayaria for Striaria nana Loomis, 1936, with a key to genera and an annotated checklist of the Striariidae (Diplopoda, Chordeumatida, Striarioidea), pp. 524-544 in Zootaxa 5463 (4) on page 538, DOI: 10.11646/zootaxa.5463.4.4, http://zenodo.org/record/11612167
Parameterizations for Gradient-based Markov Chain Monte Carlo on the Stiefel Manifold: A Comparative Study
Creators: name: Tanaka, Masahiro
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computation (stat.CO)
subject: FOS: Computer and information sciences

description: Orthogonal matrices play an important role in probability and statistics, particularly in high-dimensional statistical models. Parameterizing these models using orthogonal matrices facilitates dimension reduction and parameter identification. However, establishing the theoretical validity of statistical inference in these models from a frequentist perspective is challenging, leading to a preference for Bayesian approaches because of their ability to offer consistent uncertainty quantification. Markov chain Monte Carlo methods are commonly used for numerical approximation of posterior distributions, and sampling on the Stiefel manifold, which comprises orthogonal matrices, poses significant difficulties. While various strategies have been proposed for this purpose, gradient-based Markov chain Monte Carlo with parameterizations is the most efficient. However, a comprehensive comparison of these parameterizations is lacking in the existing literature. This study aims to address this gap by evaluating numerical efficiency of the four alternative parameterizations of orthogonal matrices under equivalent conditions. The evaluation was conducted for four problems. The results suggest that polar expansion parameterization is the most efficient, particularly for the high-dimensional and complex problems. However, all parameterizations exhibit limitations in significantly high-dimensional or difficult tasks, emphasizing the need for further advancements in sampling methods for orthogonal matrices.
description: Proceedings of the 2024 3rd Asia Conference on Algorithms, Computing and Machine Learning, pp. 397-402
Multiple epitope-based vaccine prediction against SARS-CoV-2 spike glycoprotein
Creators: name: Sirohi, Preeti Rana
name: Gupta, Jyoti
name: Somvanshi, Pallavi
name: Prajapati, Vijay Kumar
name: Grover, Abhinav
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: The global emergence of novel coronavirus disease and its rapid global expansion over a short span of time require effective countermeasures to combat it. Development of a specific vaccine can induce an optimal antibody response, thus providing immunity against it. Our study proposes a detailed and comprehensive immunoinformatic approach that can be applied to the currently available coronavirus protein data in the online server for vaccine candidate development. We have identified the receptor binding domain (RBD) of structural spike protein (S1) as a potential target for immunity against COVID- 19 infection. Epitope prediction illustrated cytotoxic T-cell epitopes, helper T-cell epitopes, and B-cell epitopes associated with the target protein. These were joined through specific linkers along with adjuvant beta-defensin located at the N-terminal to create a multi epitope subunit vaccine (MESV). The specificity in the binding of the devised vaccine candidate to the TLR-3 immune cell receptor was evaluated via molecular docking interaction studies. Good docking score combined with robust interactions in the binding cavity certified the stringency of the engineered vaccine. Molecular dynamics simulation data showed minimal variation of the root-mean square deviations (RMSDs) and root-mean-square fluctuations (RMSFs) which confirmed the interaction stability. These results obtained from various in-silico experiments indicate the potency of this vaccine candidate as a probable therapeutic agent against COVID-19. Vaccination strategies targeting conserved epitope-based immune response would be beneficial in providing cross protection across beta-coronaviruses, and such vaccines would be resistant to the ever-evolving viruses. Communicated by Ramaswamy H. Sarma
title: Predocedure Abdominopelvic Computed Tomography: How Does Waiting Time Affect The Patient.
Creators: name: Mahajan, Abhishek
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Professional issues
subject: Audit and standards
subject: Audit/Professional Issues - Your latest results

description: Purpose Study/Project design Results Discussion Conclusions References Personal Information
description: Purpose: To assess the waiting time prior to patient undergoing abdominopelvic CT under various circumstances. To assess patient compliance in the various groups. To detect the common problems faced by the patient and ways to rectify them. We compared the...
title: Lung Cancer Diagnosis on Chest Radiography - our Performance in the past 12 months
Creators: name: Teoh, Eugene
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Professional issues
subject: Audit and standards
subject: Audit/Professional Issues - Your latest results

description: Purpose Study/Project design Results Discussion Conclusions References Personal Information
description: Purpose: Introduction Chest radiography is a widely used investigation requested by both primary care and hospital doctors. Earlier diagnosis of lung cancer may confer a better prognosis, thus early identification of lesions on chest radiography is crucial 1...
Sonnenfleckenzeichnung Nr. 213.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 11.09.1975, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
Efficiency Analysis & Recommendations Concerning the 200ml Water Bottling Process for Areej
Creators: name: Alhosani, Nayef
Publisher: name: American University of Bahrain
Year: 2024
Subjects: classificationCode: 40
subject: Engineering
classificationCode: 401404
subject: Industrial engineering

description: Businesses face intense competition in the market today. Increased productivity enables producers to meet client needs effectively, deliver products faster, and keep a competitive advantage. During COVID-19 Areej started to face inefficiencies in their production processes, which caused a 10% decrease in their output of the 200ml water bottles production process. This project investigates possible countermeasures that can be implemented by Areej to stabilize their current production process and increase the output of the 200ml water bottle boxes. Through using a Fishbone diagram to identify the possible root causes and a voting system was used to identify the primary root causes. A PDSA pilot test was conducted in March to stabilize the current production process and increase productivity. Three months plan (through April, May, and June) was recommended for Areej to increase their productivity by 8% if the plan was implemented. The recommendations stemming from this project will have the potential to be applied across other production processes within Areej factory.
Combination of QSAR, molecular docking, molecular dynamic simulation and MM-PBSA: analogues of lopinavir and favipiravir as potential drug candidates against COVID-19
Creators: name: Rafi, Md. Oliullah
name: Bhattacharje, Gourab
name: Al-Khafaji, Khattab
name: Taskin-Tok, Tugba
name: Alfasane, Md. Almujaddade
name: Das, Amit Kumar
name: Parvez, Md. Anowar Khasru
name: Rahman, Md. Shahedur
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Pandemic COVID-19 infections have spread throughout the world. There is no effective treatment against this disease. Viral RNA-dependent RNA polymerase (RdRp) catalyzes the replication of RNA from RNA and the main protease (Mpro) has a role in the processing of polyproteins that are translated from the RNA of SARS-CoV-2, and thus these two enzymes are strong candidates for targeting by anti-viral drugs. Small molecules such as lopinavir and favipiravir significantly inhibit the activity of Mpro and RdRp in vitro. Studies have shown that structurally modified lopinavir, favipiravir, and other similar compounds can inhibit COVID-19 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp). In this study, lopinavir and its structurally similar compounds were chosen to bind the main protease, and favipiravir was chosen to target RNA-dependent RNA polymerase. Molecular docking and the quantitative structure-activity relationships (QSAR) study revealed that the selected candidates have favorable binding affinity but less druggable properties. To improve the druggability, four structural analogues of lopinavir and one structural analogue of favipiravir was designed by structural modification. Molecular interaction analyses have displayed that lopinavir and favipiravir analogues interact with the active site residues of Mpro and RdRp, respectively. Absorption, distribution, metabolism, excretion and toxicity (ADMET) properties, medicinal chemistry profile, and physicochemical features were shown that all structurally modified analogues are less toxic and contain high druggable properties than the selected candidates. Subsequently, 50 ns molecular dynamics simulation of the top four docked complexes demonstrated that CID44271905, a lopinavir analogue, forms the most stable complex with the Mpro. Further MMPBSA analyses using the MD trajectories also confirmed the higher binding affinity of CID44271905 towards Mpro. In summary, this study demonstrates a new way to identify leads for novel anti-viral drugs against COVID-19. Communicated by Ramaswamy H. Sarma
title: Impact of a Direct Referral Pathway for Suspected Lung Cancer on Chest Radiography
Creators: name: Teoh, Eugene
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Professional issues
subject: Audit and standards
subject: Audit/Professional Issues - Your latest results

description: Purpose Study/Project design Results Discussion Conclusions References Personal Information
description: Purpose: Introduction Chest radiography is a widely used investigation requested by both primary care and hospital doctors. Earlier diagnosis of lung cancer may confer a better prognosis, thus early identification of lesions on chest radiography is crucial 1...
Sonnenfleckenzeichnung Nr. 65.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.03.1975, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
Molecular docking studies of phytocompounds of Rheum emodi Wall with proteins responsible for antibiotic resistance in bacterial and fungal pathogens: in silico approach to enhance the bio-availability of antibiotics
Creators: name: Rolta, Rajan
name: Salaria, Deeksha
name: Kumar, Vikas
name: Patel, Chirag N.
name: Sourirajan, Anuradha
name: Baumler, David J.
name: Dev, Kamal
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Rheum emodi Wall. (Himalayan rhubarb) has many pharmacological activities such as antioxidant, antimicrobial, antiviral, anticancer and wound healing. The present study was aimed to understand if major phytocompounds of Rheum emodi could bind proteins responsible for antibiotic resistance in bacterial and fungal pathogens and enhance the potency of antibiotics. The major phytocompounds of R. emodi (emodin, rhein-13c6 and chrysophenol dimethy ether) were retrieved from the Pubchem and target proteins were retrieved from RCSB protein data bank. The docking study was performed by using AutoDock vina software and Molinspiration, swiss ADME servers were used for the determination of Lipinski rule of 5, drug-likeness prediction respectively, whereas, admetSAR and Protox-II tools were used for toxicity prediction. To study the docking accuracy of protein-ligand complexes, MD simulation for 100 ns was done by using Desmond program version 2.0 (Academic version). Among all the selected phytocompounds, emodin showed the best binding affinity against bacterial (Penicillin binding protein 3, 3VSL and fungal target (cytochrome P450 14 alpha-sterol demethylase 1EA1) with binding energy −8.2 and −8.0 Kcal mol−1 respectively. Similarly, rhein-13C6 showed the best binding affinity against fungal target (n-myristoyl transferase 1IYL) with binding energy −8.0 Kcal mol−1 which is higher than antibacterial and antifungal antibiotics. All the selected phytocompounds also fulfill Lipinski rule, non-carcinogenic and non-cytotoxic in nature. These compounds also showed high LD50 value showing non-toxicity of these phytocompounds. MD simulation studies of phytocompounds (emodin and rhein-13C6) define the stability of protein-ligand complexes with in 100 ns time scale. Communicated by Freddie R. Salsbury
Sonnenfleckenzeichnung Nr. 249.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 27.10.1975, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
title: Confidence and knowledge in plain film radiology interpretation amongst FY1 Doctors in South-East Scotland.
Creators: name: Watson, David
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Professional issues
subject: Audit and standards
subject: Audit/Professional Issues - Your latest results

description: Purpose Study/Project design Results Discussion Conclusions References Personal Information
description: Purpose: Traditionally, radiology is not formally taught at undergraduate level, yet junior doctors may be the first to view radiographs, and instigate treatment based on their interpretation. We aimed: a) To determine Foundation Year 1 (FY1) doctors’...
title: Status of Barium Studies In Present Era: Are They A History?
Creators: name: Mahajan, Abhishek
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Professional issues
subject: Audit and standards
subject: Audit/Professional Issues - Your latest results

description: Purpose Study/Project design Results Discussion Conclusions References Personal Information
description: Purpose: The purpose of this exhibit is: (1) To review the reasons for the continuing decline in barium studies and its effects on the quality procedures, (2) Evaluate the role of barium studies in the diagnosis gastrointestinal pathologies and evidence...
Miniaria Shear & Marek 2023
Creators: name: Shear, William A.
name: Marek, Paul E.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Chordeumatida
Striariidae
Miniaria

description: Genus Miniaria Shear & Marek, 2023
Miniaria Shear & Marek, 2023, Zootaxa 5264: 325.
Type species, Miniaria ramifera Shear & Marek, 2023, by original designation. Two species.
description: Published as part of Shear, William A. & Marek, Paul E., 2024, The millipede family Striariidae Bollman, 1893. IX. The identity of Striaria californica Cook, 1899, and the new genus Bayaria for Striaria nana Loomis, 1936, with a key to genera and an annotated checklist of the Striariidae (Diplopoda, Chordeumatida, Striarioidea), pp. 524-544 in Zootaxa 5463 (4) on page 538, DOI: 10.11646/zootaxa.5463.4.4, http://zenodo.org/record/11612167
Multiple epitope-based vaccine prediction against SARS-CoV-2 spike glycoprotein
Creators: name: Sirohi, Preeti Rana
name: Gupta, Jyoti
name: Somvanshi, Pallavi
name: Prajapati, Vijay Kumar
name: Grover, Abhinav
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: The global emergence of novel coronavirus disease and its rapid global expansion over a short span of time require effective countermeasures to combat it. Development of a specific vaccine can induce an optimal antibody response, thus providing immunity against it. Our study proposes a detailed and comprehensive immunoinformatic approach that can be applied to the currently available coronavirus protein data in the online server for vaccine candidate development. We have identified the receptor binding domain (RBD) of structural spike protein (S1) as a potential target for immunity against COVID- 19 infection. Epitope prediction illustrated cytotoxic T-cell epitopes, helper T-cell epitopes, and B-cell epitopes associated with the target protein. These were joined through specific linkers along with adjuvant beta-defensin located at the N-terminal to create a multi epitope subunit vaccine (MESV). The specificity in the binding of the devised vaccine candidate to the TLR-3 immune cell receptor was evaluated via molecular docking interaction studies. Good docking score combined with robust interactions in the binding cavity certified the stringency of the engineered vaccine. Molecular dynamics simulation data showed minimal variation of the root-mean square deviations (RMSDs) and root-mean-square fluctuations (RMSFs) which confirmed the interaction stability. These results obtained from various in-silico experiments indicate the potency of this vaccine candidate as a probable therapeutic agent against COVID-19. Vaccination strategies targeting conserved epitope-based immune response would be beneficial in providing cross protection across beta-coronaviruses, and such vaccines would be resistant to the ever-evolving viruses. Communicated by Ramaswamy H. Sarma
title: Hematuria: what to order (evidence based review)
Creators: name: Roque, Andreia
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Professional issues
subject: Audit and standards
subject: Audit/Professional Issues - Your latest results

description: Purpose Study/Project design Results Discussion Conclusions References Personal Information
description: Purpose: The aim of this educational poster is: 1) to review relevant studies concerning diagnostic evaluation of hematuria in the adult,supported on good quality secondary evidence baseddatabases search; 2) to discuss evidence levels in these studies; 3) to...
Sonnenfleckenzeichnung Nr. 179.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.08.1975, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
title: How to deal with additional findings seen in pre-therapeutic breast MRI and their impact on therapeutic approach, re-excision and recurrence rates. A prospective longitudinal single-institutional study in 465 patients.
Creators: name: Camps-Herrero, Julia
Publisher: name: European Congress of Radiology
Year: 2010
Subjects: subject: Breast
subject: Breast - Your latest results

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Breast MRI (BMRI) is the technique that most accurately depicts breast cancer due to various facts: it relies on the capacity of low-molecular weight contrast agents (gadolinium chelates) to represent indirectly neoangiogenesis in breast tumors...
Miniaria ramifera Shear & Marek 2023
Creators: name: Shear, William A.
name: Marek, Paul E.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Chordeumatida
Striariidae
Miniaria
Miniaria ramifera

description: Miniaria ramifera Shear & Marek, 2023
Miniaria ramifera Shear & Marek, 2023, Zootaxa 5264: 326. Male holotype and male and female paratypes from Mashel River at State Route 7, Pierce Co., Washington (CAS). Known from localities in Pierce and Skamania Cos., Washington, and from Multnomah and Washington Cos., Oregon.
description: Published as part of Shear, William A. & Marek, Paul E., 2024, The millipede family Striariidae Bollman, 1893. IX. The identity of Striaria californica Cook, 1899, and the new genus Bayaria for Striaria nana Loomis, 1936, with a key to genera and an annotated checklist of the Striariidae (Diplopoda, Chordeumatida, Striarioidea), pp. 524-544 in Zootaxa 5463 (4) on page 538, DOI: 10.11646/zootaxa.5463.4.4, http://zenodo.org/record/11612167
Structural stability of antimicrobial peptides rich in tryptophan, proline and arginine: a computational study
Creators: name: Marimuthu, Sathish Kumar
name: Nagarajan, Krishnanand
name: Perumal, Sathish Kumar
name: Palanisamy, Selvamani
name: Subbiah, Latha
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: The host defense peptides or antimicrobial peptides (AMPs) often contain short sequence of amino acids, either positive or negatively charged and express broad-spectrum antibacterial, antiviral and antifungal activity. Many researchers had reported that tryptophan, arginine and proline rich AMPs have a promising source of next-generation antibiotics. Nowadays, AMPs are used as a possible therapeutic source for future antibiotics. In the present study, the amino acid sequences of 2924 AMPs belonging to various sources rich in Tryptophan, Proline and Arginine was chosen for investigation. The AMPs were further categorized according to their source, structure and antimicrobial activities. The AMPs with tryptophan, arginine, proline residues in abundance with maximum sequence length of 20 amino acids alone was obtained. Homology modeling was performed with PEP-FOLD and the modeled structures were evaluated using RAMPAGE to identify the structural information. Further, the stability of peptide in aqueous condition was probed using molecular dynamics simulations. Communicated by Ramaswamy H. Sarma
Sonnenfleckenzeichnung Nr. 67.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 01.04.1975, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1975

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert