cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
НАПРАВЛЕНИЯ ПО УЛУЧШЕНИЮ ФИНАНСОВОГО СОСТОЯНИЯ СЕЛЬСКОХОЗЯЙСТВЕННОГО КООПЕРАТИВА
Creators: name: Пильникова И.Ф.
name: Кот Е.М.
name: Горбунова О.С.
name: Малькова Ю.В.
name: Петрякова С.В.
Publisher: name: Образование и право
Year: 2022
Subjects: финансовое состояние
эффективность
анализ
финансовая модель.

description: Значимость проведения оценки эффективности предприятий отрасли АПК на основе анализа финансового состояния обусловлена и непростыми условиями функционирования отечественных сельскохозяйственных предприятий, для которых характерны высокие и нестабильные затраты, необходимость формирования больших запасов для нормальной производственной деятельности, а также отсутствие у них собственных систем товародвижения и распределения готового продукта. В неблагоприятные периоды у сельскохозяйственных предприятий существенно уменьшается продуктивность труда и урожайность, поэтому при оценке финансового состояния необходимо учитывать неравномерность трудовых ресурсов и производственных процессов. Поэтому можно говорить о том, что выбранная для исследования тема представляется актуальной.
Entropy of AT(n) systems
Creators: name: Munteanu, Radu-B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37A35, 37A40

description: In this paper we show that any ergodic measure preserving transformation of a standard probability space which is AT$(n)$ for some positive integer $n$ has zero entropy. We show that for every positive integer $n$ any Bernoulli shift is not AT($n$). We also give an example of a transformation which has zero entropy but does not have property AT($n$), for any integer $n\geq 1$.
Computational design of affinity and specificity at protein–protein interfaces
Creators: name: Karanicolas, John
name: Kuhlman, Brian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The computer-based design of protein-protein interactions is a rigorous test of our understanding of molecular recognition and an attractive approach for creating novel tools for cell and molecular research. Considerable attention has been placed on redesigning the affinity and specificity of naturally occurring interactions. Several studies have shown that reducing the desolvation costs for binding while preserving shape complimentarity and hydrogen bonding is an effective strategy for improving binding affinities. In favorable cases specificity has been designed by focusing only on interactions with the target protein, while in cases with closely related off-target proteins, it has been necessary to explicitly disfavor unwanted binding partners. The rational design of protein-protein interactions from scratch is still an unsolved problem, but recent developments in flexible backbone design and energy functions hold promise for the future.
Forks, pincers, and triggers: the tools for nucleotide incorporation and translocation in multi-subunit RNA polymerases
Creators: name: Erie, Dorothy A
name: Kennedy, Scott R
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The central role of RNA polymerase (RNAP) is to catalyze the processive synthesis of a growing RNA transcript. Recent structural and biophysical data have lead to a deeper understanding of the nucleotide addition cycle and insight into the structure-function relationships that govern transcription elongation. In this review, we discuss kinetic data on nucleotide incorporation in the context of crystal structures, which show RNAP in multiple conformations. We present a facilitated Brownian ratchet model of nucleotide incorporation, in which templated NTP binding to a non-catalytic site in the main channel promotes the conformational changes that lead to opening of the catalytic site and translocation.
НЕКОТОРЫЕ АСПЕКТЫ ИССЛЕДОВАНИЯ СИСТЕМЫ САМОУПРАВЛЕНИЯ И ОБЩЕСТВЕННО-ПРАВОВЫХ ФУНКЦИЙ ДЖАМААТА ГОРЦЕВ ДАГЕСТАНА XIX ВЕКЕ
Creators: name: Магомедова Р.М.
name: Саидова М.З.
name: Нахибашев З.М.
name: Гусейнова И.С.
Publisher: name: Образование и право
Year: 2022
Subjects: джамаат
самоуправление
Нагорный Дагестан
горцы
общество.

description: В статье рассматриваются взгляды некоторых авторов, таких как: С.П. Броневский, Н.И. Воронов, Е. Марков, И.И. Норденстам и других на развитие самоуправления джамаатов союзов сельских обществ Нагорного Дагестана XIX века, раскрываются общественно-правовых функций джамаата. Авторы дают свой анализ этим суждениям.
Advances in RNA Secondary and Tertiary Structure Analysis by Chemical Probing
Creators: name: Weeks, Kevin M
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: RNA is arguably the most versatile biological macromolecule due to its ability both to encode and to manipulate genetic information. The diverse roles of RNA depend on its ability to fold back on itself to form biologically functional structures that bind small molecules and large protein ligands, to change conformation, and to affect the cellular regulatory state. These features of RNA biology can be structurally interrogated using chemical mapping experiments. The usefulness and applications of RNA chemical probing technologies have expanded dramatically over the past five years due to several critical advances. These innovations include new sequence-independent RNA chemistries, algorithmic tools for high-throughput analysis of complex data sets composed of thousands of measurements, new approaches for interpreting chemical probing data for both secondary and tertiary structure prediction, facile methods for following time-dependent processes, and the willingness of individual research groups to tackle increasingly bold problems in RNA structural biology.
Data Generation for Testing and Grading SQL Queries
Creators: name: Chandra, Bikash
name: Chawda, Bhupesh
name: Kar, Biplab
name: Reddy, K. V. Maheshwara
name: Shah, Shetal
name: Sudarshan, S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Databases (cs.DB)
subject: FOS: Computer and information sciences
subject: H.2

description: Correctness of SQL queries is usually tested by executing the queries on one or more datasets. Erroneous queries are often the results of small changes, or mutations of the correct query. A mutation Q' of a query Q is killed by a dataset D if Q(D) $\neq$ Q'(D). Earlier work on the XData system showed how to generate datasets that kill all mutations in a class of mutations that included join type and comparison operation mutations. In this paper, we extend the XData data generation techniques to handle a wider variety of SQL queries and a much larger class of mutations. We have also built a system for grading SQL queries using the datasets generated by XData. We present a study of the effectiveness of the datasets generated by the extended XData approach, using a variety of queries including queries submitted by students as part of a database course. We show that the XData datasets outperform predefined datasets as well as manual grading done earlier by teaching assistants, while also avoiding the drudgery of manual correction. Thus, we believe that our techniques will be of great value to database course instructors and TAs, particularly to those of MOOCs. It will also be valuable to database application developers and testers for testing SQL queries.
description: 34 pages, The final publication is available at Springer via http://dx.doi.org/10.1007/s00778-015-0395-0
Meßfeier mit Kindern - lebendig gestaltet mit Orff-Instrumenten
Creators: name: Baldemair, Vinzenz
name: Gerg, Kaspar
name: Steinacher, Magdalena
Publisher: name: Diakonia
Year: 1970

description: Diakonia, Bd. 12 Nr. 3 (1981): Diakonia, Band 12, Heft 3
НЕКОТОРЫЕ ОСОБЕННОСТИ РАЗВИТИЯ ИНДУСТРИИ ТУРИЗМА В РЕСПУБЛИКЕ ДАГЕСТАН
Creators: name: Абдулов М.Р.
Publisher: name: Образование и право
Year: 2022
Subjects: въездной туризм
туристский рынок
межкультурному общению
объекты курортно-санаторного отдыха
региональная экономика.

description: Рассмотрены особенности туристического рынка Дагестана на современном этапе. Автор отмечает, что туризм в настоящее время является одной из важных областей региональной экономики, которая направлена на удовлетворение потребностей людей и повышение качества их жизни. Выявлены основные проблемы в этой социально-экономической сфере. Для анализа использовался материал официальной статистики. Зафиксированы основные тенденции на перспективу дальнейшего развития рынка туристических услуг в Республике Дагестан.
НЕКОТОРЫЕ ПРОБЛЕМЫ НАЛОГОВОГО ПРАВА, СВЯЗАННЫЕ С ВОЗВРАТОМ ИЗЛИШНЕ УПЛАЧЕННЫХ И ИЗЛИШНЕ ВЗЫСКАННЫХ НАЛОГОВ
Creators: name: Краснобрыжева А.А.
name: Терещенко А.С.
name: Деникаева Р.Н.
Publisher: name: Образование и право
Year: 2022
Subjects: суд
взыскание
возврат
налог
налогоплательщик
инстанция
налоговый орган.

description: Данная тема актуальна, поскольку в последние годы замечается тенденция к увеличению судебных разбирательств в сфере возврата переплаченных налогов, а это значит, что в налоговом механизме имеются пробелы, которые следует заполнить. Статья посвящена проблемам возврата излишне взысканных и излишне уплаченных денежных средств, а именно тому, как налогоплательщику вернуть переплаченные средства и не допустить нарушения его конституционных прав в сфере налогообложения. Помимо этого, изложены достоинства и недостатки налоговой системы РФ, а также перспективы ее развития посредством внедрения различного рода налоговых механизмов. К тому же в данной статье будут описаны различного рода последствия, которые могут возникнуть при переплате налоговых средств в соответствующий бюджет, и проведен анализ судебной практики и практики Министерства финансов РФ, касающиеся неоднозначных ситуаций, связанных с возвратом переплаченных денежных средств. Целью работы является исследование проблем, связанных с возвратом излишне взысканных и излишне уплаченных средств налогоплательщиков. В соответствии с целью были поставлены такие задачи, как: рассмотрение вопросов, связанных с принудительным взысканием налогов и добровольной их переплатой; анализ способов защиты прав налогоплательщиков в части, касающейся возврата переплаченных средств; выявление возможных путей совершенствования налогового законодательства. Поставленные в работе задачи предопределили использование следующих методов: анализ, синтез, сравнительно-правовой, системный подход и функциональный подход.
НЕКОТОРЫЕ ПРОЦЕССУАЛЬНЫЕ ОСОБЕННОСТИ СУДЕБНОЙ ЗАЩИТЫ ПРАВА БЫТЬ ИЗБРАННЫМ
Creators: name: Котов И.Н.
Publisher: name: Образование и право
Year: 2022
Subjects: избирательные права граждан
пассивное избирательное право
судебная защита избирательных прав

description: В настоящей статье автором исследуется вопрос судебной защиты такого пассивного избирательного права, как права быть избранным. Анализируется разработанность законодательства административного судопроизводства, предусматривающее защиту соответствующего права. Исследуются причины сдерживания эффективности судебной защиты права быть избранным, а также анализируются пути решения сложившихся проблем.
High Dimensional Low Rank plus Sparse Matrix Decomposition
Creators: name: Rahmani, Mostafa
name: Atia, George
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: Data Structures and Algorithms (cs.DS)
subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: This paper is concerned with the problem of low rank plus sparse matrix decomposition for big data. Conventional algorithms for matrix decomposition use the entire data to extract the low-rank and sparse components, and are based on optimization problems with complexity that scales with the dimension of the data, which limits their scalability. Furthermore, existing randomized approaches mostly rely on uniform random sampling, which is quite inefficient for many real world data matrices that exhibit additional structures (e.g. clustering). In this paper, a scalable subspace-pursuit approach that transforms the decomposition problem to a subspace learning problem is proposed. The decomposition is carried out using a small data sketch formed from sampled columns/rows. Even when the data is sampled uniformly at random, it is shown that the sufficient number of sampled columns/rows is roughly O(rμ), where μis the coherency parameter and r the rank of the low rank component. In addition, adaptive sampling algorithms are proposed to address the problem of column/row sampling from structured data. We provide an analysis of the proposed method with adaptive sampling and show that adaptive sampling makes the required number of sampled columns/rows invariant to the distribution of the data. The proposed approach is amenable to online implementation and an online scheme is proposed.
description: IEEE Transactions on Signal Processing
The influence of personal experience on tolerance for wildlife and support for management in New Jersey
Creators: name: Paulin, Joseph B.
Publisher: name: No Publisher Supplied
Year: 2023

description: In the early 2000s, increases in white-tailed deer (Odocoileus virginianus), Canada goose (Branta canadensis), and black bear (Ursus americanus) populations led to the establishment of these species in suburban areas throughout New Jersey, USA. As a result, the state’s wildlife and human populations were coming into contact and conflict more than ever before. The economic impacts from unwanted deer-human interactions in New Jersey were conservatively estimated at $69,000,000 annually. Canada geese negatively impacted agricultural crops and raised concerns about human health and safety issues. As the black bear population expanded, bear-human conflicts rose from 285 in 1995 to over 3,000 by 2003. We initiated mail surveys to determine the factors that led to support for lethal and non-lethal management techniques. Surveys were sent to (N=3,000) single-family residences with high and low population densities of deer, geese, and bear. A primary objective of the surveys was to determine the thresholds at which respondents’ attitudes shift (tolerance/intolerance) towards the various species and the factors that determine these thresholds. Several analyses, including One-Way ANOVA, Potential for conflict Index₂, Exploratory and Confirmatory Factor Analysis, and Structural Equation Modeling, were used to explore potential differences between residents in high and low-density wildlife areas, and the influence of personal experiences on respondents’ attitudes toward tolerance for wildlife and support for specific lethal and non-lethal management techniques. Our structural equation models take a new approach that builds on previous research and goes beyond showing how concerns or limited experiences predict intolerance. By surveying residents with greater experience we demonstrate how communities become intolerant of abundant and expanding wildlife populations. Additionally, where previous models often end at tolerance, our model further elucidates how intolerance influences support for lethal and non-lethal management. Intolerance was also an important mediator of the indirect effects of experience on support for management, especially among communities with lower levels of experience. Our models advance our understanding of the influence of unwanted or negative interactions with wildlife.
The power of correlative microscopy: multi-modal, multi-scale, multi-dimensional
Creators: name: Caplan, Jeffrey
name: Czymmek, Kirk J
name: Niethammer, Marc
name: Taylor, Russell M
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Correlative microscopy is a sophisticated approach that combines the capabilities of typically separate, but powerful microscopy platforms: often including, but not limited, to conventional light, confocal and super-resolution microscopy, atomic force microscopy, transmission and scanning electron microscopy, magnetic resonance imaging and micro/nanoCT (computed tomography). When targeting rare or specific events within large populations or tissues, correlative microscopy is increasingly being recognized as the method of choice. Furthermore, this multi-modal assimilation of technologies provides complementary and often unique information, such as internal and external spatial, structural, biochemical and biophysical details from the same targeted sample. The development of a continuous stream of cutting-edge applications, probes, preparation methodologies, hardware and software developments will enable realization of the full potential of correlative microscopy.
НОРМАТИВНЫЕ АСПЕКТЫ ПРИМЕНЕНИЯ ПРОМЫШЛЕННЫХ ТОВАРОВ, ПРОИСХОДЯЩИХ ИЗ ИНОСТРАННЫХ ГОСУДАРСТВ (26 КЛАСС)
Creators: name: Новицкая Л.Ю.
name: Орловская М.А.
Publisher: name: Образование и право
Year: 2022
Subjects: Импортозамещение
запрет на допуск промышленных товаров
происходящих из иностранных государств
закупка по государственному оборонному заказу
образцы ВВСТ
реестр
подтверждение соответствия
перечень исключений
Минпромторг России
Классификатор ОКПД 2 класс 26
Евразийский экономический союз.

description: В данной статье проведен анализ нормативных правовых актов, регламентирующих порядок использования товаров иностранного производства 26 класса в целях осуществления закупки для нужд обороны страны и безопасности государства.
О НЕКОТОРЫХ АКТУАЛЬНЫХ ПРОБЛЕМАХ ЛИЦЕНЗИРОВАНИЯ ЛИЦ, ОСУЩЕСТВЛЯЮЩИХ ДЕЯТЕЛЬНОСТЬ ПО УПРАВЛЕНИЮ МНОГОКВАРТИРНЫМИ ДОМАМИ
Creators: name: Чернова П.А.
name: Шобей Л.Г.
Publisher: name: Образование и право
Year: 2022
Subjects: лицензирование
государственный жилищный надзор
государственная информационная система жилищно-коммунального хозяйства
оператор системы.

description: В статье поднимаются проблемы прохождения управляющими организациями процедуры продления сроков действия лицензий на осуществление деятельности по управлению многоквартирными домами. Делается акцент на лицензионном требовании о размещении информации в ГИС ЖКХ. Раскрываются основные проблемы, связанные с исполнением данного требования. Анализируется законодательство. Подчеркивается необходимость принятия законопроекта о продлении срока действий лицензий для устранения пробелов в законодательстве.
Strategies to control the binding mode of de novo designed protein interactions
Creators: name: Kuhlman, Brian
name: Der, Bryan S
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: There has been significant recent progress in the computational design of protein interactions including the creation of novel heterodimers, homodimers, nanohedra, fibril caps and a protein crystal. Essential to these successes has been the use of innovative strategies for finding binding modes that are achievable, i.e. identifying binding partners and docked conformations that can be successfully stabilized via sequence optimization and backbone refinement. In many cases this has involved the use of structural motifs commonly found at naturally occurring interfaces including alpha helices inserted into hydrophobic grooves, beta-strand pairing, metal binding, established helix packing motifs, and the use of symmetry to form cooperative interactions. Future challenges include the creation of hydrogen bond networks and antibody-like interactions based on the redesign of protein surface loops.
О НЕКОТОРЫХ ВОПРОСАХ СОВЕРШЕНСТВОВАНИЯ ИЗБИРАТЕЛЬНОЙ СИСТЕМЫ В КЫРГЫЗСКОЙ РЕСПУБЛИКЕ
Creators: name: Соодонбеков А.А.
Publisher: name: Образование и право
Year: 2022
Subjects: выборы
депутаты
Жогорку Кенеш Кыргызской Республики
избирательное законодательство
избирательная система
Конституция
Парламент референдум.

description: C момента обретения независимости в Кыргызстане выборы проводились в неполноценной конкурентной среде и не всегда в соответствии с демократическими стандартами. В статье рассматриваются вопросы исторического развития избирательной системы в контексте изменений законодательства о выборах в Кыргызской Республике. Автором анализируются результаты современного этапа реформирования избирательной системы в свете дальнейшего ее совершенствования в условиях формирования демократического государства и гражданского общества в Кыргызской Республике. На сегодняшний день процесс трансформации избирательной системы Кыргызской Республики продолжается, она еще далека от совершенства. Актуальность приобретают вопросы определения эффективности современного избирательного процесса в Кыргызском государстве и необходимость их научного осмысления для выработки конкретных путей дальнейшего политической модернизации общества в сторону закрепления реально функционирующего избирательного законодательства.
Quantum arithmetic with the Quantum Fourier Transform
Creators: name: Ruiz-Perez, Lidia
name: Garcia-Escartin, Juan Carlos
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The Quantum Fourier Transform offers an interesting way to perform arithmetic operations on a quantum computer. We review existing Quantum Fourier Transform adders and multipliers and propose some modifications that extend their capabilities. Among the new circuits, we propose a quantum method to compute the weighted average of a series of inputs in the transform domain.
description: 14 pages, 5 figures. Revised version with corrected and expanded results. Comments are welcome
SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission
Creators: name: Donaldson, Eric
name: Bolles, Meagan
name: Baric, Ralph
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Most new emerging viruses are derived from strains circulating in zoonotic reservoirs. Coronaviruses, which had an established potential for cross-species transmission within domesticated animals, suddenly became relevant with the unexpected emergence of the highly pathogenic human SARS-CoV strain from zoonotic reservoirs in 2002. SARS-CoV infected approximately 8000 people worldwide before public health measures halted the epidemic. Supported by robust time-ordered sequence variation, structural biology, well-characterized patient pools, and biological data, the emergence of SARS-CoV represents one of the best studied natural models of viral disease emergence from zoonotic sources. This review article summarizes previous and more recent advances into the molecular and structural characteristics, with particular emphasis on host-receptor interactions, that drove this remarkable virus disease outbreak in human populations.
Novel mechanisms of EBV-induced oncogenesis
Creators: name: Raab-Traub, Nancy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Epstein-Barr virus is an etiologic factor in multiple types of cancer that primarily develop in lymphocytes and epithelial cells. The tumors are latently infected yet express distinct subsets of viral proteins that are essential for transformation. The viral oncogenes may be expressed in a subset of cells and are transferred through exosomes to many cells to induce growth and alter the tumor environment. In some of the viral cancers, viral proteins are not expressed, however, the viral miRNAs can alter growth by decreasing expression of negative regulators of cell growth such as tumor suppressors and cellular proteins that induce apoptosis.
ОПРЕДЕЛЕНИЕ КРУГА СУБЪЕКТОВ АДМИНИСТРАТИВНОЙ ЮРИСДИКЦИИ В РАМКАХ АДМИНИСТРАТИВНО-ДЕЛИКТНОГО ЗАКОНОДАТЕЛЬСТВА РОССИЙСКОЙ ФЕДЕРАЦИИ
Creators: name: Еремеев В.Ю.
name: Ларинбаева И.И.
name: Шагапов И.Р.
name: Ягудин Д.Р.
Publisher: name: Образование и право
Year: 2022
Subjects: административная юрисдикция
административно-деликтное право
субъекты административной юрисдикции
административное право
административное судопроизводство
органы государственного управления.

description: Согласно Конституции Российской Федерации административное, административно-процессуальное законодательство находится в совместном ведении Российской Федерации и субъектов Российской Федерации (п. «к» ч. 1 ст. 72). Отечественное административно-деликтное законодательство Российской Федерации постоянно реформируется, в частности подготовлены проекты нового Кодекса Российской Федерации об административных правонарушениях, Процессуального кодекса Российской Федерации об административных правонарушениях, федерального закона «О введении в действие Кодекса Российской Федерации об административных правонарушениях и Процессуального кодекса Российской Федерации об административных правонарушениях». Совершенствование механизма органов административной юрисдикции является ключевым направлением развития административно-деликтного законодательства Российской Федерации в связи с чем подвергается постоянному изменению. Вопрос об определении круга субъектов административной юрисдикции вызывает ряд дискуссий между отечественными авторами с советских времен и до настоящего времени. В связи с этим Это исследование направлено на определение круга субъектов административной юрисдикции в рамках административно-деликтного законодательства российской федерации.
О ПРОБЛЕМАХ ПРЕДУПРЕЖДЕНИЯ ЭКОНОМИЧЕСКОЙ ПРЕСТУПНОСТИ ПРАВООХРАНИТЕЛЬНЫМИ ОРГАНАМИ
Creators: name: Потоцкий Н.К.
name: Неволин С.А.
Publisher: name: Образование и право
Year: 2022
Subjects: экономическая преступность
органы внутренних дел
причины преступности
меры предупреждения экономической преступности.

description: В статье рассматриваются проблемы предупреждения экономической преступности соответствующими подразделениями органов внутренних дел. Предлагается ряд мер по предупреждению экономической преступности.
Kaposi sarcoma associated herpesvirus pathogenesis (KSHV)—an update
Creators: name: Dittmer, Dirk P
name: Damania, Blossom
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Kaposi sarcoma-associated herpesvirus (KSHV) is the etiological agent of several human malignancies. The virus is able to modulate pro-proliferative pathways to its advantage, while simultaneously inhibiting pro-apoptotic signaling pathways. These functions are carried out by multiple viral proteins acting in concert. The overall outcome is the survival and proliferation of the infected cell. Additionally, the virus also modulates innate immune pathways to allow for prolonged survival of the infected cell following primary infection, and during viral latency. Here we review the latest advances in our knowledge of KSHV pathogenesis.
Roseomics: a blank slate
Creators: name: Moorman, Nathaniel J
name: Murphy, Eain A
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Recent technological advances have led to an explosion in the system-wide profiling of biological processes in the study of herpesvirus biology, herein referred to as “-omics”. In many cases these approaches have revealed novel virus-induced changes to host cell biology that can be targeted with new antiviral therapeutics. Despite these successes, -omics approaches are not widely applied in the study of roseoloviruses. Here we describe examples of how -omics studies have shaped our understanding of herpesvirus biology, and discuss how these approaches might be used to identify host and viral factors that mediate roseolovirus pathogenesis.
Remark on Continued Fractions, Moebius Transformations and Cycles
Creators: name: Kisil, Vladimir V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 30B70, 51M05

description: In a recent paper A.Beardon and I.Short proposed to use chains of tangent horocycles as an extended tool describing continued fractions. We review the origin of such construction from the Moebius transformations point of view. Related descriptions with chains of orthogonal horocycles emerged as a result. The approach is extended to several dimensions in a way which is compatible to the early proposition of A.Beardon based on Clifford algebras.
description: AMS-LaTeX, 8 pages, 6 EPS files in one figure; v2: new figure, new references, extended introduction; v3: minor revision, connection of continued fractions with cycles explicitly claimed
title: Cultural values and human rights: a matter of interpretation
Creators: name: McGrogan, David
Publisher: name: University of Liverpool Repository
Year: 2013

description: This thesis addresses a neglect of legal analysis in the scholarship on cultural relativism, international human rights law, and Asian values. While a wealth of scholarship exists on cultural relativism as a philosophical or political question, and while the cultural rights of members of minority groups are often addressed from a legal perspective in the context of the European Court of Human Rights, the interaction between broader cultural values – those operant at the societal level – and human rights standards has not been adequately analysed as a question of law. Chapter I provides an overview of the debates on cultural relativism to detail how questions of law have been neglected, and how they would complement the existing scholarship if fully addressed. It concludes there is a need to examine how far international human rights law permits cultural values to affect the manner and extent of implementation as an empirical issue. Chapter II makes it clear that the core question is one of interpretation – i.e., in seeking to establish whether cultural values are permitted to affect implementation of human rights norms in any fashion, this hinges on how the terms of international human rights treaties are interpreted so as to permit it, or not. Chapter III then takes this principle and sets out what the accepted rules of treaty interpretation are, and how international human rights treaty terms in particular are to be interpreted in light of their unique character. This leads us to what is sometimes argued to be the legal basis for the programmatic interpretation of human rights treaties: Article 31(3)(b) of the Vienna Convention on the Law of Treaties, or subsequent practice establishing the agreement of the parties on a given interpretation. We postulate that the interpretations given by the United Nations human rights treaty bodies are potentially constitutive of subsequent practice under the Vienna Convention, and, if so, we argue that this would be the most appropriate focal point for answering our core question. The rules guiding the use and formation of subsequent practice, however, are not clear. Chapter IV examines what guidelines have been developed in other contexts; in particular, this involves surveying the jurisprudence of the International Court of Justice and the World Trade Organization’s Dispute Settlement Procedure, and drawing some inferences from that jurisprudence to arrive at a method for assessing the development of subsequent practice in international human rights law. Using this pattern of analysis, Chapter V then illustrates how it can be applied by using a case study – the interpretive practice of the Committee for the Elimination of Discrimination Against Women regarding Singapore, Malaysia, and Indonesia – and draws preliminary conclusions to demonstrate how this mode of analysis addresses the gap in the scholarship.
ОРГАНИЗАЦИЯ УЧЁТА ЗАТРАТ И ВЫХОДА ПРОДУКЦИИ СКОТОВОДСТВА В СЕЛЬСКОМ ХОЗЯЙСТВЕ
Creators: name: Шарапова В.М.
name: Шарапов Ю.В.
Publisher: name: Образование и право
Year: 2022
Subjects: затраты
учет
выход продукции скотоводства
анализ
себестоимость
сельское хозяйство
эффективность.

description: Система документального оборота системы учёта затрат производства закладывается в основу работы сельскохозяйственного предприятия и должна соответствовать нормативно-правовой базе, принятой со стороны государства. В данной статье авторами рассмотрены вопросы учёта затрат предприятия молока и приплода. В рамках предприятий сферы животноводства при выходе продукции удаётся получить несколько видов взаимосвязанной продукции. В статье рассмотрены особенности учета затрат и выхода продукции скотоводства в сельском хозяйстве, объектом исчисления выступает приплод и надой молока. Как правило, объекты учёта расходов затрат и объекты их исчисления не совпадают и, как следствие, требуется их сбалансированное распределение в рамках взаимосвязанных видов продукции. Система учёта затрат сельскохозяйственного предприятия даёт возможность сотрудникам бухгалтерии и руководителю предприятия осуществлять эффективный контроль за рациональным использованием материально-финансовых и трудовых ресурсов предприятия, возможность разрабатывать эффективные управленческие решения, обеспечивающие конкурентоспособность и эффективность сельскохозяйственного предприятия. Актуальность: Гарантией достижения продовольственной безопасности государства является стабильность и эффективность работы сельскохозтоваропроизводителей, по нашему мнению, наличие четкой, налаженной системы учета затрат и выхода продукции скотоводства в сельском хозяйстве способствует конкурентоспособности сельскохозяйственных предприятий и обеспечению продовольственной безопасности. Предмет и объект: Объектом настоящего исследования выбрано сельское хозяйство, предмет исследования – организация учета затрат и выхода продукции скотоводства в сельском хозяйстве.
Systems approaches to coronavirus pathogenesis
Creators: name: Ferris, Martin T
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Coronaviruses comprise a large group of emergent human and animal pathogens, including the highly pathogenic SARS-CoV and MERS-CoV strains that cause significant morbidity and mortality in infected individuals, especially the elderly. As emergent viruses may cause episodic outbreaks of disease over time, human samples are limited. Systems biology and genetic technologies maximize opportunities for identifying critical host and viral genetic factors that regulate susceptibility and virus-induced disease severity. These approaches provide discovery platforms that highlight and allow targeted confirmation of critical targets for prophylactics and therapeutics, especially critical in an outbreak setting. Although poorly understood, it has long been recognized that host regulation of virus-associated disease severity is multigenic. The advent of systems genetic and biology resources provide new opportunities for deconvoluting the complex genetic interactions and expression networks that regulate pathogenic or protective host response patterns following virus infection. Using SARS-CoV as a model, dynamic transcriptional network changes and disease-associated phenotypes have been identified in different genetic backgrounds, leading to the promise of population-wide discovery of the underpinnings of Coronavirus pathogenesis.
Ripple Down Rules for Question Answering
Creators: name: Nguyen, Dat Quoc
name: Nguyen, Dai Quoc
name: Pham, Son Bao
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computation and Language (cs.CL)
subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: Recent years have witnessed a new trend of building ontology-based question answering systems. These systems use semantic web information to produce more precise answers to users' queries. However, these systems are mostly designed for English. In this paper, we introduce an ontology-based question answering system named KbQAS which, to the best of our knowledge, is the first one made for Vietnamese. KbQAS employs our question analysis approach that systematically constructs a knowledge base of grammar rules to convert each input question into an intermediate representation element. KbQAS then takes the intermediate representation element with respect to a target ontology and applies concept-matching techniques to return an answer. On a wide range of Vietnamese questions, experimental results show that the performance of KbQAS is promising with accuracies of 84.1% and 82.4% for analyzing input questions and retrieving output answers, respectively. Furthermore, our question analysis approach can easily be applied to new domains and new languages, thus saving time and human effort.
description: V1: 21 pages, 7 figures, 10 tables. V2: 8 figures, 10 tables; shorten section 2; change sections 4.3 and 5.1.2. V3: Accepted for publication in the Semantic Web journal. V4 (Author's manuscript): camera ready version, available from the Semantic Web journal at http://www.semantic-web-journal.net
Animal models of tumorigenic herpesviruses—an update
Creators: name: Sin, Sang-Hoon
name: Dittmer, Dirk P
name: Damania, Blossom
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Any one model system, be it culture or animal, only recapitulates one aspect of the viral life cycle in the human host. By providing recent examples of animal models for Epstein Barr Virus and Kaposi Sarcoma-associated Herpesvirus, we would argue that multiple animal models are needed to gain a comprehensive understanding of the pathogenesis associated with human oncogenic herpesviruses. Transgenic mice, homologous animal herpesviruses, and tumorgraft and humanized mouse models all complement each other in the study of viral pathogenesis. The use of animal model systems facilitates the exploration of novel antiviral and anti-cancer treatment modalities for diseases associated with oncogenic herpesviruses.
How do persistent infections with hepatitis C virus cause liver cancer?
Creators: name: Mitchell, Jonathan K
name: Lemon, Stanley M
name: McGivern, David R
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Persistent infection with hepatitis C virus (HCV) is associated with an increased risk of hepatocellular carcinoma (HCC). Cancer typically develops in a setting of chronic hepatic inflammation and advanced fibrosis or cirrhosis, and such tissue represents a pre-neoplastic “cancer field”. However, not all persistent infections progress to HCC and a combination of viral and host immune factors likely to contribute to carcinogenesis. HCV may disrupt cellular pathways involved in detecting and responding to DNA damage, potentially adding to the risk of cancer. Efforts to unravel how HCV promotes HCC are hindered by lack of a robust small animal model, but a better understanding of molecular mechanisms could identify novel biomarkers for early detection and allow for development of improved therapies.
ОСОБЕННОСТИ ПРИМЕНЕНИЯ ПОЛОЖЕНИЙ ГРАЖДАНСКОГО ПРОЦЕССУАЛЬНОГО КОДЕКСА РОССИЙСКОЙ ФЕДЕРАЦИИ, КАСАЮЩИХСЯ НАПРАВЛЕНИЯ ЛИЦАМ, УЧАСТВУЮЩИМ В ДЕЛЕ КОПИЙ ИСКОВОГО ЗАЯВЛЕНИЯ, А ТАКЖЕ ПОРЯДКА ИСЧИСЛЕНИЯ СРОКОВ ВСТУПЛЕНИЯ СУДЕБНЫХ АКТОВ В ЗАКОННУЮ СИЛУ
Creators: name: Павлюк Ю.Б.
Publisher: name: Образование и право
Year: 2022
Subjects: исковое заявление
уведомление о вручении копии искового заявления
решение суда первой инстанции
дополнительное решение
срок вступления в законную силу
процессуальные сроки
обжалование решение суда
обжалование дополнительного решения.

description: В статье рассматриваются отдельные аспекты применения положений Гражданского процессуального кодекса Российской Федерации, касающиеся порядка подачи искового заявления, в том числе направления копий искового заявления лицам, участвующим в деле. Анализируются противоречия, имеющиеся в нормах процессуального права, которые формируют различные подходы в судебной практике по этому вопросу. Исследуется вопрос, касающийся срока вступления в законную силу решения суда первой инстанции в случае принятия судом дополнительного решения.
Reassessing immune control of hepatitis A virus
Creators: name: Walker, Christopher M
name: Lemon, Stanley M
name: Feng, Zongdi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: There is renewed interest in hepatitis A virus (HAV) pathogenesis and immunity after 2–3 decades of limited progress. From a public health perspective, the average age at infection has increased in developing countries, resulting in more severe hepatitis that is poorly understood mechanistically. More fundamentally, there is interest in comparing immunity to HAV and hepatitis C virus (HCV): small, positive-strand RNA viruses with very different infection outcomes. Here, we review evidence that circulating HAV virions are cloaked in membranes, with consequences for induction of innate immunity and antibody-mediated neutralization. We also consider the contribution of CD4+ helper versus CD8+ cytotoxic T cells to antiviral immunity and liver injury, and present a model of non-cytotoxic immune control of HAV infection.
title: Studies of the sprad and diversity of the insect Symbiont Arsenophonus Nasoniae
Creators: name: Parratt, Steven
Publisher: name: University of Liverpool Repository
Year: 2014

description: Heritable bacterial endosymbionts are a diverse group of microbes, widespread across insect taxa. They have evolved numerous phenotypes that promote their own persistence through host generations, ranging from beneficial mutualisms to manipulations of their host’s reproduction. These phenotypes are often highly diverse within closely related groups of symbionts and can have profound effects upon their host’s biology. However, the impact of their phenotype on host populations is dependent upon their prevalence, a trait that is highly variable between symbiont strains and the causative factors of which remain enigmatic. In this thesis I address the factors affecting spread and persistence of the male-killing endosymbiont Arsenophonus nasoniae in populations of its host Nasonia vitripennis. I present a model of A. nasoniae dynamics in which I incorporate the capacity to infectiously transmit as well as direct costs of infection – factors often ignored in treaties on symbiont dynamics. I show that infectious transmission may play a vital role in the epidemiology of otherwise heritable microbes and allows costly symbionts to invade host populations. I then support these conclusions empirically by showing that: a) A. nasoniae exerts a tangible cost to female N. vitripennis it infects, b) it only invades, spreads and persists in populations that allow for both infectious and heritable transmission. I also show that, when allowed to reach high prevalence, male-killers can have terminal effects upon their host population. Secondly, I examine the phenotypic and genetic differences of a novel strain of Arsenophonus that has recently diverged from the male-killer following a host-shift event. I show that interspecific transmission can lead to rapid changes in symbiont biology, shifting away from reproductive parasitism and reliance upon mixed transmission towards mutualism, pure heritability and host-specialisation. I also show that these transitions are underpinned by specific genomic diversification. These findings have important implications for the way in which we view symbiont dynamics in nature and predict their outcome in terms of virulence and phenotype evolution. Further, it highlights the rapid directed selection pressures that symbionts are regularly exposed to following a host-shift and how this may be responsible for the diversity seen in nature.
Efficient storage of Pareto points in biobjective mixed integer programming
Creators: name: Adelgren, Nathan
name: Belotti, Pietro
name: Gupte, Akshay
Publisher: name: arXiv
Year: 2014
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: Optimization and Control (math.OC)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: E.1.7
subject: 90C29, 68P05, 90C11,

description: In biobjective mixed integer linear programs (BOMILPs), two linear objectives are minimized over a polyhedron while restricting some of the variables to be integer. Since many of the techniques for finding or approximating the Pareto set of a BOMILP use and update a subset of nondominated solutions, it is highly desirable to efficiently store this subset. We present a new data structure, a variant of a binary tree that takes as input points and line segments in $\R^2$ and stores the nondominated subset of this input. When used within an exact solution procedure, such as branch-and-bound (BB), at termination this structure contains the set of Pareto optimal solutions. We compare the efficiency of our structure in storing solutions to that of a dynamic list which updates via pairwise comparison. Then we use our data structure in two biobjective BB techniques available in the literature and solve three classes of instances of BOMILP, one of which is generated by us. The first experiment shows that our data structure handles up to $10^7$ points or segments much more efficiently than a dynamic list. The second experiment shows that our data structure handles points and segments much more efficiently than a list when used in a BB.
title: Fast folding dynamics of proteins and peptides
Creators: name: Whynes, Renee
Publisher: name: University of Liverpool Repository
Year: 2011

description: The dynamics of protein folding has become a major area of research interest today, particularly in biophysical chemistry. The first steps of protein folding have been reported to occur on the 100-ns time scale, made possible by with the development of several experimental techniques. For this research, laser induced temperature jumps coupled to infrared spectroscopy were used for observing the fast folding dynamics of a small protein and a peptide on the nanosecond time scale by probing changes in the amide I band, which is sensitive to secondary structure. This research project also describes the development and demonstration of a new photochemical triggering technique for protein folding. Peptide and poly-ethylene glycol-capped gold nanoparticles were tested and used as heat transducers for inducing temperature jumps in protein and peptide samples. The results demonstrate that, for the typical concentration used in our temperature jump measurements, the nanoparticles do not affect the helix-coil transition of proteins and peptides. We also describe a new method for subtracting the pressure relief artifact observed after a ns-temperature jump. Application of this method allows us to identify a hidden phase on the nanosecond time scale in the temperature jump induced dynamics of a small protein. The effect of pD and temperature on the fast folding dynamics of a small protein (BBL) was studied. The results show, for the first time, that the protein exhibits three distinct phases; two nanosecond phases and a microsecond phase. However, we found that the nanosecond components are not easily distinguished due to similarities in the time constants. Finally, this research project also describes the development of a new photo-triggering method which is based on a photocleavage reaction that generates the desired functional group from an inactive caged one upon photolysis, namely the photocleavage reaction of a peptide that is covalently bonded to 4,5-dimethoxy-2-nitrobenzyl. Our experimental results show, that cleavage of the backbone peptide is very fast, so that the photo-triggering technique is valid for observing the fast dynamics of peptides and proteins on the nanosecond/microsecond timescale.
The (logarithmic) Sobolev inequalities along geometric flow and applications
Creators: name: Fang, Shouwen
name: Zheng, Tao
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53C21, 53C44

description: For some class of geometric flows, we obtain the (logarithmic) Sobolev inequalities and their equivalence up to different factors directly and also obtain the long time non-collapsing and non-inflated properties, which generalize the results in the case of Ricci flow or List-Ricci flow or harmonic-Ricci flow. As applications, for mean curvature flow in Lorentzian space with nonnegative sectional curvature and twisted Kähler-Ricci flow on Fano manifolds, we get the results above.
description: 35pages,correct some typos