cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer
Creators: name: Wang, Yingxue
name: Zeitouni, Daniel
name: Stalnecker, Clint A.
name: Ying, Haoqiang
name: Knudsen, Erik S.
name: Zhang, Guo-Fang
name: Singh, Pankaj K.
name: Witkiewicz, Agnieszka K.
name: Gunda, Venugopal
name: Tikunov, Andrey P.
name: Cox, Adrienne D.
name: Tomar, Garima
name: Peng, Sen
name: Klomp, Jennifer E.
name: Waters, Andrew M.
name: Pierobon, Mariaelena
name: Diehl, J. Nathaniel
name: Hayes, Tikvah K.
name: Yan, Liang
name: Hobbs, G. Aaron
name: Petricoin, Emanuel F.
name: Der, Channing J.
name: Macdonald, Jeffrey M.
name: Lyssiotis, Costas A.
name: Kimmelman, Alec C.
name: Goode, Gennifer D.
name: George, Samuel D.
name: Tran, Nhan L.
name: Bryant, Kirsten L.
name: Papke, Björn
name: Chaika, Nina V.
Publisher: name: Springer Nature
Year: 2019

description: Pancreatic ductal adenocarcinoma (PDAC) is characterized by KRAS- and autophagy-dependent tumorigenic growth, but the role of KRAS in supporting autophagy has not been established. We show that, to our surprise, suppression of KRAS increased autophagic flux, as did pharmacological inhibition of its effector ERK MAPK. Furthermore, we demonstrate that either KRAS suppression or ERK inhibition decreased both glycolytic and mitochondrial functions. We speculated that ERK inhibition might thus enhance PDAC dependence on autophagy, in part by impairing other KRAS- or ERK-driven metabolic processes. Accordingly, we found that the autophagy inhibitor chloroquine and genetic or pharmacologic inhibition of specific autophagy regulators synergistically enhanced the ability of ERK inhibitors to mediate antitumor activity in KRAS-driven PDAC. We conclude that combinations of pharmacologic inhibitors that concurrently block both ERK MAPK and autophagic processes that are upregulated in response to ERK inhibition may be effective treatments for PDAC.
Native English Speaking Teachers' Use of Corrective Feedback in a Thai Speaking Oriented ESL Context
Creators: name: Charles, Tyler
name: Wachira Tangkawanit
name: Siriporn Ketnarongrattana
name: Kittitouch Soontornwipast
Publisher: name: RANGSIT  UNIVERSITY  Thailand.
Year: 2016
Subjects: corrective feedback, native English-speaking teachers, Thai speaking oriented ESL context

description: Rangsit  Journal of  Educational Studies, 3, 1
Supplementary document for Nonlocality-mediated spatiotemporal optical vortex generation in nanorod-based epsilon-near-zero metamaterials - 6327528.pdf
Creators: name: Novikov, Vladimir
name: Murzina, Tatyana
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Free space propagation of high-order STOV; singularity point breakup at air gap thinning in cascaded HMM; laser pulse transmission through cascaded HMM for different air gap thicknesses.
Comparing EMG-Based Human-Machine Interfaces for Estimating Continuous, Coordinated Movements
Creators: name: Pan, Lizhi
name: Crouch, Dustin L.
name: Huang, He
Publisher: name: Institute of Electrical and Electronics Engineers (IEEE)
Year: 2019

description: Electromyography (EMG)-based interfaces are trending toward continuous, simultaneous control with multiple degrees of freedom. Emerging methods range from data-driven approaches to biomechanical model-based methods. However, there has been no direct comparison between these two types of continuous EMG-based interfaces. The aim of this study was to compare a musculoskeletal model (MM) with two data-driven approaches, linear regression (LR) and artificial neural network (ANN), for predicting continuous wrist and hand motions for EMG-based interfaces. Six able-bodied subjects and one transradial amputee subject performed (missing) metacarpophalangeal (MCP) and wrist flexion/extension, simultaneously or independently, while four EMG signals were recorded from forearm muscles. To add variation to the EMG signals, the subjects repeated the MCP and wrist motions at various upper extremity postures. For each subject, the EMG signals collected from the neutral posture were used to build the EMG interfaces; the EMG signals collected from all postures were used to evaluate the interfaces. The performance of the interface was quantified by Pearson's correlation coefficient (r) and the normalized root mean square error (NRMSE) between measured and estimated joint angles. The results demonstrated that the MM predicted movements more accurately, with higher r values and lower NRMSE, than either LR or ANN. Similar results were observed in the transradial amputee. Additionally, the variation in r across postures, an indicator of reliability against posture changes, was significantly lower (better) for the MM than for either LR or ANN. Our findings suggest that incorporating musculoskeletal knowledge into EMG-based human-machine interfaces could improve the estimation of continuous, coordinated motion.
AstroSamantha protagonista d’un podcast Spaziale
Creators: Valentina Guglielmo
Publisher: name: Media Inaf
Year: 2022

S’intitola “Spaziale”, è un podcast prodotto da Chora Media e condotto da Silvia Bencivelli che racconta, attraverso il viaggio verso la Iss di Samantha Cristoforetti, come è cambiato lo spazio negli anni e come si vive e si prepara, oggi, un lancio spaziale. Le prime tre puntate sono già online
Electrocardiogram of a Silver Nanowire Based Dry Electrode: Quantitative Comparison With the Standard Ag/AgCl Gel Electrode
Creators: name: Qin, Qin
name: Huang, He
name: Li, Jianqing
name: Liu, Chengyu
name: Yao, Shanshan
name: Zhu, Yong
Publisher: name: Institute of Electrical and Electronics Engineers (IEEE)
Year: 2019

description: Novel dry electrodes have promoted the development of wearable electrocardiogram (ECG) that is collected in daily life to monitor the ambulatory activity of heart status. To evaluate the performance of a dry electrode, it is necessary to compare it with the commercial disposable silver/silver chloride (Ag/AgCl) gel electrode. In this paper, a silver nanowire (AgNW)-based dry electrode was fabricated for noninvasive and wearable ECG sensing. Signals from the AgNW electrode and the Ag/AgCl electrode were simultaneously collected in two conditions: sitting and walking. Signal quality was evaluated in terms of ECG morphology, R-peak to R-peak interval, and heart rate variability analysis. Quantitative comparisons showed that the AgNW electrode could collect acceptable ECG waveforms as the Ag/AgCl electrode in both the sitting and walking conditions. However, the baseline drift and waveform distortions existed in the AgNW electrode, likely due to electrode motion. If the skin-electrode contact is improved, the dry electrode can be a promising substitute for the Ag/AgCl electrode.
Così esplodono le micronove, piccole ma potenti
Creators: Redazione Media Inaf
Publisher: name: Media Inaf
Year: 2022

Un gruppo di astronomi, con l’aiuto del Very Large Telescope (Vlt) dell’Eso, ha osservato un nuovo tipo di esplosione stellare: una micronova. Queste esplosioni si verificano sulla superficie di alcune stelle e ciascuna può bruciare in poche ore materiale stellare pari a circa 3,5 miliardi di Grandi Piramidi di Giza. Con il commento di Domitilla De Martino dell’Inaf di Napoli
Pier Luigi Lopalco: kui kõik läheb hästi, on leetrite kõrvaldamine mõne aasta küsimus
Creators: name: Lohk, Marina
Publisher: name: OÜ Celsius Healthcare
Year: 2016

description: Eesti Arst 2016; 95(2):76–78
description: Eesti Arst, Veebruar 2016
Il primo pianeta di Sphere? Non era un pianeta
Creators: Marco Malaspina
Publisher: name: Media Inaf
Year: 2022

Ritenuto inizialmente un esopianeta, l’oggetto HD 131399Ab, individuato nel 2016 con lo strumento Sphere al Vtl dell’Eso, si è rivelato essere un falso positivo: in realtà era una stella sullo sfondo. La vicenda si è ora conclusa con la ritrattazione dell’articolo su Science da parte del team che aveva firmato la scoperta. Con un commento di Silvano Desidera dell’Inaf di Padova
Associations between exposure to air pollution and health : a longitudinal study of middle-aged and older adults in China
Creators: name: Hu, Kai
Publisher: name: The University of St Andrews
Year: 2022
Subjects: Air pollution
Elderly health
Frailty
Multimorbidity
Cognitive decline
Longitudinal analysis
China

description: The Chinese population is ageing rapidly, and older Chinese adults (aged 45 and over) have spent a large proportion of their lives exposed to historically high levels of air pollution (AP). Previous studies suggest that there is a strong association between AP and individual health outcomes, but most of them have relied on cross-sectional measures of AP exposure and health, or both. These limit our understanding of how short-term, long-term, and cumulative exposures lead to changes in health outcomes. This PhD thesis addresses these gaps by investigating the longitudinal relationship between long-term and short-term exposure to AP and the health of older adults in China. The thesis uses two kinds of survey data and two kinds of AP data. The Chinese Longitudinal Healthy Longevity Survey (CLHLS) 2011 and 2014 is linked with monitoring station AP data (used in chapter 4), and the China Health and Retirement Longitudinal Survey (CHARLS) 2011, 2013 and 2015, is linked with PM₂.₅ data that are retrieved from satellite data via remote sensing technology (used in chapters 5 and 6). The main finding of the first empirical chapter using the CLHLS is that increased frailty incidence is associated with higher long-term exposure to AP rather than short-term fluctuations. The second empirical chapter using the CHARLS shows that exposure to PM₂.₅ over 15 years is associated with higher multimorbidity accumulation, and higher levels of PM₂.₅ are associated with a higher likelihood of membership to both respiratory and cardio-metabolic disease classes. The results of the third empirical chapter indicate that long-term exposure to PM₂.₅ is associated with poorer cognitive function, but different measures of long-term AP exposure are associated with different levels of cognitive decline. Overall, the three chapters indicate that long-term AP exposure has a negative association with elderly health, but that there may be some individual and contextual differences which are being conflated with these associations, and which deserve further exploration. This thesis, therefore, makes several substantive and methodological contributions. First, I create a unique longitudinal dataset by linking historical AP data to representative longitudinal ageing surveys at the city level. Second, I investigate the associations of short-term and long-term exposure with health outcomes. Third, health outcomes of older adults are measured longitudinally using three comprehensive indicators that can reflect the complex relationship between AP and elderly health. The findings highlight the need to further consider cumulative and life-course AP exposure on elderly health at a smaller geographical scale.
title: Covalent modification of a ten-residue cationic antimicrobial peptide with levofloxacin
Creators: name: Rodriguez, Carlos A.
name: Papanastasiou, Emilios A.
name: Juba, Melanie
name: Bishop, Barney
Publisher: name: Frontiers Media
Year: 2014
Subjects: subject: Cationic antimicrobial peptide
subject: Peptide conjugate
subject: Antibiotics
subject: Peptide modification
subject: Levofloxacin

description: The rampant spread of antibiotic resistant bacteria has spurred interest in alternative strategies for developing next-generation antibacterial therapies. As such, there has been growing interest in cationic antimicrobial peptides (CAMPs) and their therapeutic applications. Modification of CAMPs via conjugation to auxiliary compounds, including small molecule drugs, is a new approach to developing effective, broad-spectrum antibacterial agents with novel physicochemical properties and versatile antibacterial mechanisms. Here, we've explored design parameters for engineering CAMPs conjugated to small molecules with favorable physicochemical and antibacterial properties by covalently affixing a fluoroquinolone antibiotic, levofloxacin, to the ten-residue CAMP Pep-4. Relative to the unmodified Pep-4, the conjugate was found to demonstrate substantially increased antibacterial potency under high salt concentrations. Historically, it has been observed that most CAMPs lose antibacterial effectiveness in such high ionic strength environments, a fact that has presented a challenge to their development as therapeutics. Physicochemical studies revealed that P4LC was more hydrophobic than Pep-4, while mechanistic findings indicated that the conjugate was more effective at disrupting bacterial membrane integrity. Although the inherent antibacterial effect of the incorporated levofloxacin molecules did not appear to be substantially realized in this conjugate, these findings nevertheless suggest that covalent attachment of small molecule antibiotics with favorable physicochemical properties to CAMPs could be a promising strategy for enhancing peptide performance and overall therapeutic potential. These results have broader applicability to the development of future CAMP-antibiotic conjugates for potential therapeutic applications.
Nel ghiaccio di Europa, come in Groenlandia
Creators: Maura Sandri
Publisher: name: Media Inaf
Year: 2022

Osservazioni effettuate da IceBridge della Nasa della calotta glaciale in Groenlandia hanno rivelato sacche d’acqua sotto a formazioni superficiali molto simili a quelle che solcano Europa, la luna di Giove. Se anche sulla luna ghiacciata fossero presenti queste sacche d’acqua poco profonde, all’interno del guscio ghiacciato potrebbero esserci le condizioni di abitabilità necessarie alla vita extraterrestre
Eesti Arstide Päevad 5. ja 6. mail 2016 Pärnus hotellis Strand
Creators: name: Liit, Eesti Arstide
Publisher: name: OÜ Celsius Healthcare
Year: 2016

description: Eesti Arst 2016; 95(2):79–80
description: Eesti Arst, Veebruar 2016
Common DNA sequence variation influences 3-dimensional conformation of the human genome
Creators: name: Schmitt, Anthony D.
name: Liu, Tristin
name: Ren, Bing
name: Chiou, Joshua
name: Li, Yun
name: Hu, Ming
name: Qiu, Yunjiang
name: Sebat, Jonathan
name: Gorkin, David U.
name: Hansen, Kasper D.
name: Noor, Amina
name: Gaulton, Kyle J.
name: Fletez-Brant, Kipper
Publisher: name: Springer Nature
Year: 2019

description: Background The 3-dimensional (3D) conformation of chromatin inside the nucleus is integral to a variety of nuclear processes including transcriptional regulation, DNA replication, and DNA damage repair. Aberrations in 3D chromatin conformation have been implicated in developmental abnormalities and cancer. Despite the importance of 3D chromatin conformation to cellular function and human health, little is known about how 3D chromatin conformation varies in the human population, or whether DNA sequence variation between individuals influences 3D chromatin conformation. Results To address these questions, we perform Hi-C on lymphoblastoid cell lines from 20 individuals. We identify thousands of regions across the genome where 3D chromatin conformation varies between individuals and find that this variation is often accompanied by variation in gene expression, histone modifications, and transcription factor binding. Moreover, we find that DNA sequence variation influences several features of 3D chromatin conformation including loop strength, contact insulation, contact directionality, and density of local cis contacts. We map hundreds of quantitative trait loci associated with 3D chromatin features and find evidence that some of these same variants are associated at modest levels with other molecular phenotypes as well as complex disease risk. Conclusion Our results demonstrate that common DNA sequence variants can influence 3D chromatin conformation, pointing to a more pervasive role for 3D chromatin conformation in human phenotypic variation than previously recognized.
Euclid, assemblati “occhi” e “cervello”
Creators: Rossella Spiga
Publisher: name: Media Inaf
Year: 2022

Il mese scorso sono state integrate con successo a Torino, presso l’azienda Thales Alenia Space, le due parti principali della navicella spaziale Euclid: il modulo di payload (o di carico) per il trasporto degli strumenti scientifici e il modulo di servizio di supporto. Nelle prossime settimane verranno montati i pannelli solari e lo schermo parasole, poi Euclid sarà testato nella sua configurazione completa
title: A Summary of Lessons Learned: Studies and Evaluations
Creators: name: United Nations
Publisher: name: United Nations Department of Political and Peacebuilding Affairs
Year: 2020
Subjects: subject: Mediation
subject: Local peacebuilding
subject: Gender
subject: Equatorial Guinea
subject: Gabon
subject: Maldives
subject: Colombia
subject: Peacekeeping

description: The United Nations Department of Political and Peacebuilding Affairs, in order to strengthen its accountability and organizational learning, commissions several evaluative exercises—lessons learned studies and evaluations—every year. This report provides key findings, lessons learned, and recommendations of evaluative exercises commissioned by the Department in 2020. These include an evaluation around the drawdown, reconfiguration and withdrawal of a number of peacekeeping operations and Special Political Missions (SPMs) and how they affected the presence and work of the wider UN. The report also focused on the UN mediation of the Equatorial Guinea-Gabon boundary dispute between 2008 and 2016, which relates to their overlapping claims of sovereignty over three islands, and the delimitation of their maritime and land boundaries. In addition there were evaluations of the increased support by the Mediation Support Unit (MSU) for local mediation initiatives and an analysis of UN engagement with the Maldives in support of its nascent democratic gains to build confidence between political actors and to foster the conditions for meaningful political dialogue and the discussion of delicate religious and societal issues. Finally, the report reviews UN efforts to advance the Women, Peace and Security (WPS) agenda during the peace negotiations (2012- 2016) and then through the establishment of two consecutive special political missions (SPMs) in Colombia to verify specific provisions of the Agreement. In its efforts to implement the WPS agenda in Colombia, the UN worked in close cooperation with the authorities and former guerrillas, the Revolutionary Armed Forces of Colombia (FARC-EP), as well as with civil society and international stakeholders.
Non si sta così male, nella periferia della Via Lattea
Creators: Ufficio stampa Inaf
Publisher: name: Media Inaf
Year: 2022

In un prossimo futuro la definizione di zona abitabile galattica potrebbe essere modificata per ampliarsi anche a regioni più esterne della nostra galassia. Questo perché sarà necessario considerare non solo la metallicità, ovvero l’abbondanza di elementi più pesanti dell’elio, ma anche la capacità del gas e della polvere interstellari di formare molecole organiche. Lo dicono i risultati di uno studio guidato da ricercatori e ricercatrici dell’Istituto nazionale di astrofisica
Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects
Creators: name: Skoskiewicz, Amanda
name: Kuhns, Douglas B
name: Makhija, Melanie
name: Hsu, Amy P
name: Escobedo, Omar
name: Steinberg, Harry N
name: Bergerson, Jenna
name: Church, Joseph A
name: Palmer, Cindy
name: Arrington, Megan E
name: Davis, Joie
name: Bhandoola, Avinash
name: Bonagura, Vincent
name: Szabolcs, Paul
name: Fink, Danielle
name: Fuleihan, Ramsay L
name: Swamydas, Muthulekha
name: Foruraghi, Ladan
name: Lionakis, Michail S
name: Das, Arundhoti
name: Campbell, Sharon
name: Leto, Thomas L
name: Holland, Steven M
name: Donkó, Agnes
Publisher: name: American Society of Hematology
Year: 2019

description: Ras-related C3 botulinum toxin substrate 2 (RAC2), through interactions with reduced NAD phosphate oxidase component p67 phox , activates neutrophil superoxide production, whereas interactions with p21-activated kinase are necessary for fMLF-induced actin remodeling. We identified 3 patients with de novo RAC2[E62K] mutations resulting in severe T- and B-cell lymphopenia, myeloid dysfunction, and recurrent respiratory infections. Neutrophils from RAC2[E62K] patients exhibited excessive superoxide production, impaired fMLF-directed chemotaxis, and abnormal macropinocytosis. Cell lines transfected with RAC2[E62K] displayed characteristics of active guanosine triphosphate (GTP)-bound RAC2 including enhanced superoxide production and increased membrane ruffling. Biochemical studies demonstrated that RAC2[E62K] retains intrinsic GTP hydrolysis; however, GTPase-activating protein failed to accelerate hydrolysis resulting in prolonged active GTP-bound RAC2. Rac2+/E62K mice phenocopy the T- and B-cell lymphopenia, increased neutrophil F-actin, and excessive superoxide production seen in patients. This gain-of-function mutation highlights a specific, nonredundant role for RAC2 in hematopoietic cells that discriminates RAC2 from the related, ubiquitous RAC1.
Inteligência Artificial na Academia: Da Teoria às Aplicações
Creators: name: De Sá Ferreira, Arthur
Publisher: name: OSF
Year: 2024

description: Aula ministrada no Programa de Pós-Graduação em Fisioterapia da UFTM (Universidade Federal do Triângulo Mineiro) e da UFU (Universidade Federal de Uberlândia)
Alkoholi tarvitamine ja sellega seotud tegurid perearsti poole pöördunud patsientide hulgas
Creators: name: Põlluste, Kaja
name: Dudanova, Veera
name: Kaldoja, Anne
name: Kansi, Helve
name: Kask, Liina
name: Oja, Ivika
name: Tammist, Piret
name: Lember, Margus
Publisher: name: OÜ Celsius Healthcare
Year: 2016

description: Taust ja eesmärk. Alkoholi liigtarvitamine on paljude terviseprobleemide otsene või kaudne põhjus. Uuringu eesmärk oli selgitada alkoholi liigtarvitamise seost perearstikeskustesse pöörduvate patsientide elukvaliteedi, terviseseisundi ja patsienti iseloomustavate taustateguritega.

Metoodika. Uuringusse kaasati 840 patsienti kuuest perearstikeskusest. Alkoholi liigtarvitamise hindamiseks kasutati AUDITi (Alcohol Use Disorders Identification Test) küsimustikku, tervisega seotud elukvaliteeti hinnati SF-36 (Short Form-36) küsimustiku abil. Uuritavate pikkust, kaalu, vöö- ja puusaümbermõõtu mõõdeti visiidi ajal, andmed riskitegurite ja terviseseisundi kohta saadi patsientide tervisekaartidelt. Lisaks koguti patsiendi taustaandmeid ning andmeid suitsetamise kohta. Alkoholi liigtarvitamisega seostuvate tegurite selgitamiseks kasutati logistilist regressioonanalüüsi.

Tulemused. 15,8%-l uuritavatest leiti tervist ohustav või kahjustav alkoholitarvitamine (AUDITi skoor ≥ 8). Tervist ohustava või kahjustava alkoholitarvitamise šanss oli oluliselt suurem 18–44aastaste, meessoost ning madalama haridustasemega patsientide hulgas. Tervist ohustava alkoholitarvitamise šanssi suurendasid ka suitsetamine ja väiksem kehamassiindeks. Patsiendi enda hinnatud tervisega seotud elukvaliteedi ja AUDITi skoori vahel seost ei ilmnenud.

Järeldused. Alkoholi liigtarvitamisega seotud tervisekahjude ennetamiseks võiks lisaks praegusel ajal soovitatud riskirühmadele AUDITi küsimustiku abil hinnata ka kõigi perearstikeskusesse pöörduvate kuni 44 aasta vanuste meessoost ning suitsetavate patsientide alkoholitarvitamist.

Eesti Arst 2016; 95(2):82–88
description: Eesti Arst, Veebruar 2016
Characterizing Sex Differences in Genetically Distinct Populations of Neurons in the Extended Amygdala
Creators: name: Boniberger, John
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: Understanding these brain circuits is crucial because dysregulated arousal responses can lead to mental health disorders such as depression or social anxiety. By identifying the neural pathways involved, we can better understand the underlying causes of these disorders and work towards developing more effective treatments to improve people's well-being and social interactions. With that, my investigation explored if PnocBNST neurons neurons and contribute to a larger goal of identifying neural correlates that drive the sex differences seen within anxiety disorders?
Identikit in 48 ore d’un asteroide near-Earth
Creators: Elena Mazzotta Epifani
Publisher: name: Media Inaf
Year: 2022

Nome in codice “scopri-e-caratterizza”, è la sequenza di procedure necessarie per arrivare alla caratterizzazione di un asteroide near-Earth appena scoperto. Un test condotto dal consorzio Neorocks a inizio aprile al Telescopio nazionale Galileo è riuscito a caratterizzare l'asteroide 2022 GC1 in meno di 48 ore dalla sua scoperta. Lo racconta oggi su Media Inaf una delle ricercatrici del progetto, Elena Mazzotta Epifani dell’Inaf di Roma
2024 Jones Jade Summer Undergraduate Research Fellowship Slidedeck
Creators: name: Jones, Jade
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: This presentation summarizes the research I conducted as a recipient of the UNC Summer Undergraduate Research Fellowship, focusing on the relationship between mindset and persistence among neuroscience students. Building on Carol Dweck's foundational theory of growth and fixed mindsets, this study examines how students' beliefs about their abilities influence their resilience and success in the challenging field of neuroscience and beyond.

Our analysis of comprehensive survey data reveals that students with a growth mindset—those who believe their abilities can be developed through dedication and hard work—exhibit higher levels of persistence and are more likely to overcome academic challenges than their peers with a fixed mindset. In contrast, a fixed mindset, where students view their abilities as static, tends to hinder both academic and professional growth. These findings and their implications are explored in greater detail throughout the presentation.
Allergia põhjuse kindlakstegemine molekulaarsete meetoditega
Creators: name: Julge, Kaja
Publisher: name: OÜ Celsius Healthcare
Year: 2016

description: Molekulaarse diagnostika kasutuselevõtt on muutnud allergia põhjuse kindlakstegemise varasema ajaga võrreldes oluliselt täpsemaks ja seega parandanud allergiliste haiguste käsitlust. Allergeeni ekstraktide asemel kasutatakse puhastatud naturaalseid või tööstuslikult saadud rekombinantseid allergeenseid molekule.
Molekulaarne diagnostika võimaldab hinnata süsteemse või lokaalse allergilise reaktsiooni tekke riski; teha kindlaks, kas patsiendil on ülitundlikkus primaarse allergeenikomponendi suhtes või esineb ristreaktiivsus; abistab arsti patsiendi nõustamisel allergeenidest hoidumise suhtes, et vältida põhjendamatuid dieedipiiranguid; võimaldab täpsemalt rakendada spetsiifilist immuunravi (SIR), sest aitab diagnoosida ülitundlikkust juhul, kui allergeeni ekstrakti suhtes on saadud nõrk või negatiivne tulemus.
Ülevaateartikli ülesanne on tutvustada kasutusel olevaid molekulaarse diagnostika võimalusi ja anda ühtlasi praktilisi nõuandeid, millest võiks igapäevases töös lähtuda.

Eesti Arst 2016; 95(2):89–96
description: Eesti Arst, Veebruar 2016
title: How Teachers Create Talent Development Contexts for Students from Historically Underrepresented Populations in Gifted Programs: A Multiple-Case Study
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2020

description: The issue of equitable representation of students from culturally, linguistically, and economically diverse backgrounds in gifted programs has challenged scholars and practitioners alike for decades (e.g., Feiring et al., 1997; Ricciardi et al., 2020; VanTassel-Baska et al., 2007). One effort to address this issue that has yielded promising results is the introduction of talent development programs as either replacements for, or gateway experiences to, traditional gifted programs (e.g., see Coleman, 2016; Horn, 2015). The purpose of this qualitative, exploratory multiple-case study was to examine how teachers create classroom contexts for talent development of students from populations historically underrepresented in gifted programs. Interviews and observations of two exemplar second grade teachers implementing a talent development model were conducted to explore the variety of ways in which teachers promoted the development of talent. Each teacher was considered a single case and data from their interviews and observations were analyzed individually through two single case analyses, as well as across cases through a cross-case synthesis. Findings from the cross-case synthesis yielded four factors key to developing classroom contexts for talent development of students from historically underrepresented populations in gifted programs: (a) collaborative relations of power, (b) impact of students’ culture, language, and experiences on instruction, (c) identity negotiation and construction, and (d) attending to the whole child. Elaborating on Barab and Plucker’s (2002) theory of talent development, a new framework for creating classroom contexts for talent development of students from historically underrepresented populations in gifted programs is presented. Implications for teacher preparation programs, schools and school districts, teachers, and future research are discussed.
Supplementary document for Olver plasmon: An accelerating surface wave with various orders - 6327750.pdf
Creators: name: Chen, Yanru
name: Tu, Zhifeng
name: hu, hongcheng
name: Zhang, Junxi
name: Feng, Zien
name: Wang, Ziyu
name: Hong, Weiyi
name: Deng, Dongmei
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Olver plasmon: An accelerating surface wave with various orders-Supplemental docunment
СЕМЕНОВОДСТВО БРЮССЕЛЬСКОЙ КАПУСТЫ: ТЕХНОЛОГИИ, ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ
Creators: name: Арипова, Шахноза
Publisher: name: Zenodo
Year: 2024

description: В статье рассматриваются современные технологии семеноводства брюссельской капусты, анализируются биологические особенности культуры, агротехнические приёмы и инновации, направленные на повышение урожайности и устойчивости растений. Выявляются основные проблемы, такие как болезни, вредители и влияние климатических изменений, а также сложности хранения семян. Особое внимание уделено перспективам дальнейших исследований, включая генетическое улучшение сортов, использование биопрепаратов и интеграцию цифровых технологий в процессы выращивания. Статья основана на данных из научной литературы и представляет собой всесторонний обзор текущих достижений и вызовов в семеноводстве брюссельской капусты.
Rasedus pärast elundisiirdamist
Creators: name: Anderson, Kristi
name: Vaas, Pille
Publisher: name: OÜ Celsius Healthcare
Year: 2016

description: 1956. aastast, mil rasestus esimene siiratud elundiga naine, on peatselt möödas 60 aastat. Elundisiirdamine suurendab viljatute naiste rasestumise tõenäosust ning täiustunud meditsiinilised teadmised võimaldavad ka siirikutega naistel raseduse edukat kulgu. Kõige rohkem on kirjeldatud rasedusi neerusiirikuga naistel, kuid see on võimalik ka pärast maksa, südame, kopsude, peensoole või isegi mitme elundi samaaegset siirdamist. Eestis on elundisiirdamisjärgseid rasedusi olnud väga vähe, kuid siirdamiste hulga suurenemine on muutnud teema aktuaalseks ka siinse arstkonna jaoks.
Artikli eesmärk on selgitada, milline on seos elundisiirdamise ja viljakuse vahel, kas ja kuidas mõjutavad rasedusaegsed immunoloogilised muutused siiratud elundit, millised on sagedasemad tüsistused siirikutega rasedatel ning mida on teada immunosupressiivse ravi mõjust loote arengule.

Eesti Arst 2016; 95(2):98–104
description: Eesti Arst, Veebruar 2016
[Letter from Hu Shiyu to Hu Shiding]
[胡世裕致胡世定的信］
Creators: name: Hu, Shiyu
Publisher: name: The University of British Columbia
Year: 2011

description: In the letter, Hu Shiyu tells Hu Shiding about the cannery's production situation. He also entrusts Hu Shiding to purchase some items for him.
Giganti “snelle”, un nuovo tipo di stelle
Creators: Maura Sandri
Publisher: name: Media Inaf
Year: 2022

Scoperto un nuovo tipo di giganti rosse, meno massicce del previsto. Analizzando i dati di archivio della missione Kepler della Nasa ne sono state trovate 40. Sono stelle che devono aver subito una considerevole perdita di peso a causa della presenza di una vorace vicina. La scoperta rappresenta un importante passo avanti verso la comprensione della vita delle stelle nella Via Lattea
ОТБОР КОРОТКОПЛЕТИСТЫХ СОРТООБРАЗЦОВ КАБАЧКА, ПЕРСПЕКТИВНЫХ ПО РАЗЛИЧНЫМ НАПРАВЛЕНИЯМ СЕЛЕКЦИИ
Creators: name: Арипова, Шахноза
name: Дусмуратова, Саодат
Publisher: name: Zenodo
Year: 2024

description: На опытном участке Научно-исследовательского института овоще-бахчевых культур Ташкентского района, Ташкентской области проведен подбор сортов короткоплетистых форм кабачка. В экспериментах изучены сорта местного происхождения: Унумдор – сорт-стандарт и Гайрат, и 18 сортов кабачка – из Российской Федерации.
Magic cattura l’esplosione d’una stella vampira
Creators: Ufficio stampa Inaf
Publisher: name: Media Inaf
Year: 2022

L’evento, il primo del suo genere a essere stato rivelato a simili energie, fa luce su una classe di fenomeni astrofisici considerati responsabili delle periodiche esplosioni che hanno luogo sulla superficie delle novae e dell’emissione di una parte dei fotoni che costituiscono il fondo di radiazione gamma che permea la nostra intera galassia. Il risultato in un articolo pubblicato oggi su Nature Astronomy
title: Paris After Dark
Creators: name: Buchwald, Art
Publisher: name: George Mason University
Year: 1995
Subjects: subject: ANTA
subject: American National Ballet Theatre
subject: Buchwald, Art
subject: Kitt, Eartha
subject: Dorsey, Frank
subject: Youskevitch, Igor
subject: Moylan, Mary Ellen
subject: Kriza, John
subject: Ratoff, Gregory

description: Clipping.
Simulata in laboratorio la formazione stellare
Creators: Maura Sandri
Publisher: name: Media Inaf
Year: 2022

Una collaborazione internazionale di scienziati ha modellato l'interazione tra i resti di supernova e le nubi molecolari utilizzando un laser ad alta potenza e una palla di schiuma. L’esperimento – condotto presso il Luli Laboratory all’Ecole Polytechnique, in Francia – ha permesso di simulare la compressione del denso gas e polvere dovuta alla propagazione di un’onda d’orto. Tutti i dettagli su Matter and Radiation at Extremes
La cometa più grande del Sistema solare
Creators: Valentina Guglielmo
Publisher: name: Media Inaf
Year: 2022

Un nuovo record firmato Hubble: il telescopio spaziale è riuscito a misurare il nucleo della cometa più grande mai vista finora. Ben 130 chilometri, e una massa di 500mila miliardi di tonnellate. Arriverà, fra poco meno di dieci anni, a 1.6 miliardi di chilometri dal Sole – una distanza simile a quella che separa la Terra da Saturno
Il mio nome è GNz7q. E sarò un quasar
Creators: Ufficio stampa Inaf
Publisher: name: Media Inaf
Year: 2022

Scoperto un oggetto distante circa 13 miliardi di anni luce dalla Terra, estremamente compatto e arrossato dalla polvere stellare. La rilevazione, effettuata grazie all’utilizzo del telescopio spaziale Hubble, farà luce sul mistero della crescita dei buchi neri supermassicci nell'universo primordiale. I risultati del lavoro, firmato fra gli altri da astrofisiche della Sapienza e dell’Inaf, sono stati pubblicati su Nature
title: Rhoda Barnes to Milton Barnes, January 26, 1865.
Creators: name: Barnes, Rhoda
Publisher: name: George Mason University
Year: 2011
Subjects: subject: Budgets, Personal
subject: Cambridge (Ohio)

description: Public domain. There are no known use restrictions.
description: Letter to Milton Barnes from his wife Rhoda Barnes. Rhoda describes the snowy and cold weather they are experiencing at home. She expresses hope that he is in some type of "winter quarters" and protected from the elements. She has heard that the war is winding down and is anticipating the time when he will come home. She relates information about people from home and their daughter.
Revitalizing of Cyclone affected Coconut Plantations
Creators: name: Selva Rani. A, K. Kavitha, S. Nazreen Hassan, R. Latha, J. Selvi, M. Jaya Bharathi and S. Suresh
Publisher: name: trends in Agriculture Science
Year: 2024

description: Cyclones are powerful natural disasters that can have devastating effects on agricultural landscapes, particularly in regions where coconut cultivation is a primary livelihood. Coconut palms, though resilient, are vulnerable to the high winds, heavy rainfall, and storm surges associated with cyclones. These extreme weather events can cause significant damage, from uprooting trees and defoliating canopies to disrupting the delicate balance of soil nutrition. The aftermath of a cyclone in a coconut garden often leaves farmers facing not only immediate losses but also long-term challenges in restoring their plantations to full productivity. Addressing these challenges requires a comprehensive approach to rejuvenation, incorporating both traditional practices and modern agricultural techniques to ensure the recovery and future resilience of coconut gardens.
title: Press Release: Gulf Oil Corporation, September 1, 1967
Creators: name: Gulf Oil Corporation
Publisher: name: George Mason University
Year: 2007
Subjects: subject: Reston (Va.)
subject: Gulf Reston, Inc.

description: Textual: press release, original; 11” x 8.5” (27.9 cm x 21.6 cm)
description: Press Release from Gulf Oil Corporation dated September 1, 1967. This press release announces the creation of Gulf Reston, Inc, which was a subsidiary of Gulf Oil Corporation. The purpose of this company was to facilitate the development of Reston, Virginia. Robert Ryan was announced to be president of this new company. A brief history of the Reston development is given in this release. Planned Community Archives Collection, rm03.12
Specchio delle mie brame, il più liquido del reame
Creators: Marco Malaspina
Publisher: name: Media Inaf
Year: 2022

La Nasa sta sperimentando un metodo per realizzare direttamente nello spazio specchi e lenti decine – o anche centinaia – di volte più grandi di quelli attuali. Il progetto si chiama Flute, il metodo – basato sulla tensione superficiale dei fluidi – è stato ideato al Technion (l’Istituto israeliano per la tecnologia) e i test in microgravità sono in corso in questi giorni sulla Stazione spaziale
Maailma Terviseorganisatsiooni raport seab uued väljakutsed tervishoiusüsteemidele kogu maailmas
Creators: name: Sinisalu, Väino
Publisher: name: OÜ Celsius Healthcare
Year: 2016

description: Eesti Arst 2016; 95(2):75
description: Eesti Arst, Veebruar 2016
title: The law of nature and the Letter to the Romans : rethinking Paul's descriptions of the Gentiles in Romans 2:14-15
Creators: name: Lewellen, Eric
Publisher: name: University of St Andrews
publisherIdentifier: https://ror.org/02wn5qz54
publisherIdentifierScheme: ROR
Year: 2018

description: In contemporary scholarship on Rom 2:14-15, there is a divide between those who find language associated with natural law and those who understand the Gentiles to be believers in Christ. This study aims to help bridge this interpretative gap. Through an examination of key expressions of natural law in the years prior to and contemporaneous with Paul and an exegesis of Rom 1:18-2:16, we shall contend that Paul applies language and tropes associated with natural law to Christ-believing Gentiles in Rom 2:14-15. In doing so, he is not endorsing a strain of natural law reasoning circulating in his day; rather, he applies the concept to a group of Christ-believing Gentiles to emphasize their moral quality and eschatological security for his Roman audience.
Spirituaalne mõõde tervise kontseptsiooni osana
Creators: name: Linnuste, Indrek
Publisher: name: OÜ Celsius Healthcare
Year: 2016

description: Artiklis on antud ülevaade spirituaalsest mõõtmest tervishoiuteenuste kontekstis, eelkõige psühhiaatrias. Teemakäsitluse rahvusvaheline aktuaalsus ja fookusesse tõusmine peegeldub teadusartiklite mahu kiires kasvus viimase 20 aasta jooksul. Spirituaalse toe pakkumine tervishoiu- ja rehabilitatsiooniteenuste ühe osana oleks samm edasi, et arvestada patsiendi ehk inimese mitmemõõtmelise olemusega.

Eesti Arst 2016; 95(2):105–108
description: Eesti Arst, Veebruar 2016
title: The Political Legitimization of Extreme Far-Right Parties in European Union Member States: A Case Study on Greece’s Golden Dawn
Creators: name: Mancuso, Andrea
Publisher: name: George Mason University
Year: 2015
Subjects: subject: Ultranationalism
subject: Political legitimacy
subject: Golden Dawn
subject: European Union
subject: Extremism
subject: Greece

description: This dissertation describes the political trend by which extreme far-right parties in European Union Member States have found political legitimacy over the past five years. Theoretical requirements for a party to be considered ‘politically legitimate,’ ‘extreme,’ and ‘far-right’ are discussed in order to accurately assess and compare many extreme-right parties that have found unprecedented success—gaining both political and social legitimacy—in their respective country. By closely examining the Golden Dawn party in Greece, this dissertation examines not only one of the most significant current threats to European democracy, but a party that has successfully utilized the Racist Platform Transformation Strategy and has yielded the benefits of it; namely, power. This research is meant to inspire political analysts to follow and evaluate the progress of these parties in an effort to prevent gross abuses of minority rights, as well as further damage to European multicultural democracies during this rise in ultranationalist sentiment.
Supplementary document for Self-assembled photonic heterostructure for visible and infrared dual-band anti-counterfeiting - 6327760.pdf
Creators: name: Li, Wenxin
name: Wang, Maoren
name: Wang, Jiong
name: Zhang, Li
name: Zhang, Linbo
name: Deng, Longjiang
name: Zhou, Peiheng
name: Xie, Jianliang
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: supplemental figures
Così si congelano le molecole negli embrioni stellari
Creators: Claudia Mignone
Publisher: name: Media Inaf
Year: 2022

Praticamente tutte le molecole, nei nuclei pre-stellari da cui nascono le stelle, si congelano sui granelli di polvere nelle primissime fasi di formazione stellare, preservando componenti importanti per lo sviluppo di futuri pianeti ed eventuali forme di vita su di essi. Lo dimostra uno studio guidato dal Max Planck, basato su osservazioni del radiotelescopio Alma. Con un commento di Daniele Galli dell'Inaf
Hubble spia una spirale serpentina
Creators: Maura Sandri
Publisher: name: Media Inaf
Year: 2022

Il telescopio spaziale Hubble ha immortalato Ngc 5921, una galassia a spirale barrata che si trova a 80 milioni di anni luce dalla Terra, nella costellazione del Serpente. Lo studio scientifico dietro questa immagine presenta sia le osservazioni di Hubble, sia quelle condotte con l’Osservatorio Gemini. Insieme, Hubble e Gemini hanno fornito agli astronomi un censimento dei vicini buchi neri supermassicci in una grande varietà di galassie
Un universo primordiale pieno di galassie starburst
Creators: Maura Sandri
Publisher: name: Media Inaf
Year: 2022

Dall’analisi di oltre 20mila galassie condotta da un gruppo guidato da Pierluigi Rinaldi dell’Università di Groningen (Paesi Bassi), è emerso che nei primi miliardi di anni dopo il Big Bang l’universo conteneva molte più galassie starburst del previsto. Dal 60 al 90 per cento delle stelle presenti nell’universo primordiale sembra essere stato prodotto da queste galassie. Tutti i dettagli su The Astrophysical Journal
Summary of “Best Practices for Bring Your Own Devices Implementation” by Michelle Njeri
Creators: name: Njeri, Michelle
name: waweru, chris
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 460499
subject: Cybersecurity and privacy not elsewhere classified

description: In her comprehensive study, Michelle Njeri explores the implementation of Bring Your Own Device (BYOD) policies in workplaces. The paper delves into the benefits and challenges associated with BYOD, emphasizing the importance of balancing productivity gains with security risks.
A caccia del fondo gravitazionale con Fermi
Creators: Marco Malaspina
Publisher: name: Media Inaf
Year: 2022

La fusione di buchi neri supermassicci riempie l‘universo di onde gravitazionali a bassa frequenza. Gli astronomi cercano di intercettarle sfruttando le onde radio emesse dalle pulsar della Via Lattea. Ora un team internazionale di scienziati ha dimostrato, attraverso i dati raccolti dal telescopio spaziale Fermi della Nasa, che oltre alle onde radio si possono usare i raggi gamma. «Potremmo raggiungere (e magari superare) la sensibilità dei radiotelescopi al brusio gravitazionale. Sarebbe un risultato bellissimo e assolutamente insperato», dice a Media Inaf Patrizia Caraveo
DETERMINING THE OPTIMAL PLANTING DATES FOR CUCUMBER HYBRIDS IN AN UNHEATED GREENHOUSE
Creators: name: Aminov, Shermuhammad
name: Khakimov, Rafiqjon
Publisher: name: Zenodo
Year: 2024

description: This article provides information on the results obtained in the study of acceptable cucumber hybrids planting periods in an unheated greenhouse. The optimal planting period for 30-day seedlings of cucumber hybrids in a greenhouse with an unheated plinth was March 10. In this, it was found in studies that the yield was 161,2 tons per hectare during the planting period of March 10 and was 115,5% or 21,7 tons more than the control.  Orzu Sardor
Piovono rocce sul bollente Wasp-178b
Creators: Laura Leonardi
Publisher: name: Media Inaf
Year: 2022

Utilizzando i dati di Hubble, un gruppo di ricercatori sta studiando le atmosfere di alcuni esopianeti gassosi di tipo gioviano estremamente caldi in orbita molto vicini alla loro stella, come quella di Wasp-178b e le sue piogge di roccia. I risultati sono stati pubblicati su Nature
Progress towards an improved measurement of the electric dipole moment of the electron
Creators: name: Ang, Daniel
Publisher: name: Zenodo
Year: 2023

description: PhD dissertation submitted to Harvard University. This work was originally submitted to Harvard University and is available in DASH at https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37375481. This Zenodo deposit is a supplementary copy to facilitate broader dissemination and DOI assignment.
Seleenimürgistus. Lahangujuhtude kirjeldus
Creators: name: Tuusov, Jana
name: Tõnisson, Mailis
name: Vassiljev, Vitali
Publisher: name: OÜ Celsius Healthcare
Year: 2016

description: 65aastane naine leiti kodust surnuna, eelmisel päeval oli leitud samast tema abikaasa – 62aastane mees. Mõlema surnukeha kohtuarstlikul lahangul jäi kahtlus raskmetallimürgistuse suhtes. Vere analüüsides leiti mõlema lahkunu vereproovis toksilistes väärtustes seleenisisaldus, mis oli otsene surmapõhjus. Lahanguleid oli mehel ja naisel sarnane: suu limaskestal oranžikaspunane õlijas aine, sarnane aine maos ja kaksteistsõrmikus, siseelundite oranžikas värvus ning dehüdreerunud välimus. Kohtuarstlikul lahangul sedastati lisaks veel mehel maksatsirroos ja hepatiit, alkoholi kontsentratsioon veres oli 1,56 mg/g (‰). Päev hiljem surnud naisel esines rasvmaks ja steatohepatiit, alkoholi kontsentratsioon veres oli 0,34 mg/g (‰).
Kirjanduse andmetel esineb inimestel ägedat seleenimürgistust äärmiselt harva ja teadaolevalt pole seda varem Eestis diagnoositud. Ägeda seleenimürgistuse korral võivad esineda tugev kõhuvalu, profuusne diarröa ja oksendamine ning küüslaugu lõhn suust.

Eesti Arst 2016; 95(2):109–111
description: Eesti Arst, Veebruar 2016
THE PSYCHOLOGY OF SUICIDAL BEHAVIOR AND ITS ESSENCE
Creators: name: Turumbetovа, Zаmirа
Publisher: name: Zenodo
Year: 2025

description: This аrticle deals with psychological foundations and essence of suicidal behavior. It delves into the emotional, cognitive, and behavioral aspects that contribute to suicidal ideation and attempts. By analyzing key theories, risk factors such as mental illness, trauma, and social isolation are discussed. The article also highlights warning signs, psychological patterns, and the role of protective factors in prevention. Special attention is given to therapeutic strategies and the importance of early intervention. Through a comprehensive review of psychological literature, the article aims to deepen the understanding of suicidal behavior and promote effective measures for reducing suicide rates.