Additional file 1: of Long non-coding RNA HOXB-AS3 promotes myeloid cell proliferation and its higher expression is an adverse prognostic marker in patients with acute myeloid leukemia and myelodysplastic syndrome
Creators: name: Huai-Hsuan Huang
name: Fei-Yun Chen
name: Wen-Chien Chou
name: Hsin-An Hou
name: Bor-Sheng Ko
name: Chien-Ting Lin
name: Jih-Luh Tang
name: Chi-Cheng Li
name: Yao, Ming
name: Woei Tsay
name: Szu-Chun Hsu
name: Shang-Ju Wu
name: Chien-Yuan Chen
name: Shang-Yi Huang
name: Mei-Hsuan Tseng
name: Hwei-Fang Tien
name: Ruey-Hwa Chen
Publisher: name: figshare
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: FOS: Health sciences
subject: 60506 Virology

description: Table S1. Correlation of HOXB-AS3 expression with clinical characteristics and frequent somatic gene mutations in de novo AML patients. Table S2. Correlation of HOXB-AS3 expression with clinical characteristics in MDS patients. Table S3. Correlation of HOXB-AS3 expression with frequent gene mutations in MDS patients. Figure S1. Overview of Hoxb5os in mouse HOXB cluster. Figure S2. Alignment of mouse Hoxb5os and human HOXB-AS3. Figure S3. HOXB-AS3 promotes S phase entering in the cell cycle regulation. Figure S4. GSEA pathway analysis of the differentially expressed genes in HOXB-AS3 knockdown cells compared to the control cells. Figure S5. Cell cycle pathway from Wikipathway analysis of downstream pathways affected by downregulation of HOXB-AS3 in the myeloid cell lines. Figure S6. DNA replication pathway from Wikipathway analysis of downstream pathways affected by downregulation of HOXB-AS3 in the myeloid cell lines. Figure S7. RB pathway from Wikipathway analysis of downstream pathways affected by downregulation of HOXB-AS3 in the myeloid cell lines. Figure S8. G1-S pathway from Wikipathway analysis of downstream pathways affected by downregulation of HOXB-AS3 in the myeloid cell lines. Figure S9. Quantitative PCR analysis of the expressions of indicated genes in TF-1 cells infected with lentivirus carrying pAS5.1w-Pbsd (control), or pAS5.1w-Pbsd-HOXB-AS3 (HOXB-AS3 overexpression). Figure S10. HOXB-AS3 expressions of AML patients and health donors. Figure S11. Survival analysis of AML patients stratified by the expressions of HOXB-AS3. Figure S12. HOXB-AS3 expression of non-APL AML patients and health donors. Figure S13. Survival analysis of non-APL AML patients stratified by the expressions of HOXB-AS3 in the NTUH AML cohort. Figure S14. HOXB-AS3 expressions of MDS patients and health donors. Figure S15. Overall survival of MDS patients stratified by the expressions of HOXB-AS3. Figure S16. Quantitative PCR analysis of the expressions of different variants in TF-1 and OCI/AML3 cell lines. (PDF 2900 kb)