Critical evaluation of dyslipidemias' clinical practice guidelines' evidence and recommendations, and their usability.
Creators: name: Deffert, Flávia
name: Tonin, Fernanda
name: Pontarolo, Roberto
name: Fernandez-Llimos, Fernando
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Pharmacy Administration, Policy and Regulation
subject: Other Pharmacy and Pharmaceutical Sciences
subject: Pharmacy and Pharmaceutical Sciences
subject: Medicine and Health Sciences
subject: Analytical, Diagnostic and Therapeutic Techniques and Equipment
subject: Other Analytical, Diagnostic and Therapeutic Techniques and Equipment

description: Clinical practice guidelines are commonly defined as 'systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances. These documents must provide high-quality and updated scientific evidence to support assertive decision-making processes and advise cinical recommendations. These documents are developed through a rigorous process that initiates by selecting a relevant health problem and performing systematic reviews to provide trustworthy evidence to support the clinical recommendations by reducing the risk of bias. Other steps of this process include the evaluation of the costs involved in the proposed treatments, analyses of the values and preferences of the stakeholders (e.g. patients, health care professionals), and verifying the practical implementation of the guideline. To fulfill their purpose, some characteristics for the clinical practice guidelines are mandatory, such as having a transparent development process, being developed by the evidence-based-medicine principles, avoiding biases, considering the cost-effectiveness of the treatments, and classifying and correlating the evidence to the strength of the proposed recommendations. To assure these features and to provide the rationing of health care, appraisal tools have been developed, such as ones that were developed by AGREE consortium – the most used nowadays worldwide. Despite the methodological rigor to develop new clinical guidelines, and the available tools to endorse them, they usually do not reach all the stakeholders they are meant to, and their clinical recommendations are not useful to physicians are not well accepted by patients or their caretakers. Other problems related by other researchers are the multiplicity of clinical practice guidelines to a single country or region that may lead to misguidance, and low resources to develop a high-quality guideline or adapt a high-quality guideline to a certain scenario. So, this project aims to perform critical appraisals of clinical practice guidelines to identify common flaws, as to provide to guideline developers new evidence to lead to better recommendations for the management of diseases and to optimize patients’ care. To evaluate the methodological and recommendation quality of clinical practice guidelines, adults' dyslipidemias clinical practice guidelines were chosen. This clinical condition can act as a cause or an aggravating factor to other chronic diseases such as heart diseases, high pressure, diabetes, and stroke. These non-communicable diseases are responsible for most global deaths – the rate increased from 60.8% in 2000 to 73.6% in 2019. So, a systematic review using Boolean connectors and keywords related to dyslipidemia will be performed in PubMed and Scopus. Further, two independent revisers will read and appraise the guidelines using AGREE-II and AGREE-REX tools, as described in their user manuals. A further statistical test will be performed to identify the differences and provide data for comparison and discussion.