cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Stellar Binary Companions to Supernova Progenitors
Creators: name: Kochanek, C. S.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: For typical models of binary statistics, 50-70% of core-collapse supernova (ccSN) progenitors are members of a stellar binary at the time of the explosion. Independent of any consequences of mass transfer, this has observational consequences that can be used to study the binary properties of massive stars. In particular, the secondary companion to the progenitor of a Type Ib/c SN is frequently (~50%) the more optically luminous star since the high effective temperatures of the stripped progenitors make it relatively easy for a lower luminosity, cooler secondary to emit more optical light. Secondaries to the lower mass progenitors of Type II SN will frequently produce excess blue emission relative to the spectral energy distribution of the red primary. Available data constrain the models weakly. Any detected secondaries also provide an independent lower bound on the progenitor mass and, for historical SN, show that it was not a Type Ia event. Bright ccSN secondaries have an unambiguous, post-explosion observational signature - strong, blue-shifted, relatively broad absorption lines created by the developing supernova remnant. These can be used to locate historical SN with bright secondaries, confirm that a source is a secondary, and, potentially, measure abundances of ccSN ejecta. Luminous, hot secondaries will reionize the SNR on time scales of 100-1000 yrs that are faster than reionization by the reverse shock, creating peculiar HII regions due to the high metallicity and velocities of the ejecta.
description: 21 pages, 2 figures, submitted to ApJ
Chondroprotective effects of low-frequency lowenergy pulsed electromagnetic fields on human cartilage explants
Creators: name: Ongaro, Alessia
name: Pellati, Agnese
name: Masieri, Federica
name: Caruso, Angelo
name: Setti, Stefania
name: Cadossi, Ruggero
name: Caruso, Gaetano
name: Nardo, Daniela
name: De Mattei, Monica
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2010
Subjects: Human cartilage; pulsed electromagnetic fields; proteoglycan metabolism; osteoarthritis

description: Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (Supplement) 2010
Stemness ability of human dental pulp stem cells related to the in vivo and in vitro aging
Creators: name: Abatangelo, Giovanni
name: Ferroni, Letizia
name: Bressan, Eriberto
name: Gardin, Chiara
name: Pinton, Paolo
name: Cortivo, Roberta
name: Sivolella, Stefani
name: Zavan, Barbara
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011
Subjects: cellule staminali adulte; invecchiamento; medicina rigenerativa; ingegneria dei tessuti

description: “Mirror, mirror on the wall, who’s the fairest of them all?“ This is certainly the most cited expression of the 21 century. We do not want to get old, and in this context a lot of hopeful are set on stem cell therapy for tissue regeneration: regeneration of skin, dermis, cartilage, bone, nervous sistem and so on. Most of all on our smile that it is our business card. Rapid and good regeneration of alveolar bone to support new dental implant is up to now ensured by the use adult mesenchymal stem cells. But are they able to conserve their stemness ability for all the age of the donors?  In light of such consideration aim of the present work has been the study of the biological properties such as proliferation and stemness ability of human adult dental pulp stem cells (DPSC) in relation to the age of the donors and to the in vitro aging.  Human dental pulps derived from  adult subjects aged 16–over 66 years have been isolated and cultured in presence of differentiative medium. Results obtained confirmed a correlation between age and conservation of stemness during in vitro aging.
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011
Additional file 1 of Patient characteristics associated with different types of prison TB: an epidemiological analysis of 921 TB cases diagnosed at an Ethiopian prison
Creators: name: Amirkhani, Asmah
name: Humayun, Maheen
name: Ye, Wen
name: Worku, Yoseph
name: Yang, Zhenhua
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Figure S1: National trends for Ethiopia based on WHO notification data and Table S1: Demographic/clinical characteristics associated with missing HIV test result as determined by multivariable log binomial regression analysis of 871 TB cases diagnosed at Kality Federal Prison, Ethiopia during 2009–2017.
Quasar photometric redshifts from incomplete data using Deep Learning
Creators: name: Curran, S. J.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Forthcoming astronomical surveys are expected to detect new sources in such large numbers that measuring their spectroscopic redshift measurements will be not be practical. Thus, there is much interest in using machine learning to yield the redshift from the photometry of each object. We are particularly interested in radio sources (quasars) detected with the Square Kilometre Array and have found Deep Learning, trained upon a large optically-selected sample of quasi-stellar objects, to be effective in the prediction of the redshifts in three external samples of radio-selected sources. However, the requirement of nine different magnitudes, from the near-infrared, optical and ultra-violet bands, has the effect of significantly reducing the number of sources for which redshifts can be predicted. Here we explore the possibility of using machine learning to impute the missing features. We find that for the training sample, simple imputation is sufficient, particularly replacing the missing magnitude with the maximum for that band, thus presuming that the non-detection is at the sensitivity limit. For the test samples, however, this does not perform as well as multivariate imputation, which suggests that many of the missing magnitudes are not limits, but have indeed not been observed. From extensive testing of the models, we suggest that the imputation is best restricted to two missing values per source. Where the sources overlap on the sky, in the worst case, this increases the fraction of sources for which redshifts can be estimated from 46% to 80%, with >90% being reached for the other samples.
description: MNRAS, pending minor revision
Sitting at the same table : participant and family member involvement at the Canadian Mental Health Association Vancouver Fraser
Creators: name: James, Ryanne
Publisher: name: The University of British Columbia
Year: 2016

description: This report is the result of a participatory community planning project designed to ensure that participants and family members of the Canadian Mental Health Association Vancouver Fraser (CMHA-VF) become actively engaged in the decision making, planning, program development, and evaluation for the Agency. The project included the formation of the Participant and Family Voice Committee (PFVC), the development of the Participant and Family Voice Committee Guiding Principles (PFVC-GP), fifteen committee meetings, two Participant and Family Voice World Café (PFV-WC) sessions, a World Café Feedback session, a workshop at the 2015 Psychosocial Rehabilitation National Conference, a presentation at the CMHA-VF Annual General Meeting, and several small group focus sessions. The report reviews the literature regarding the importance of participant and family involvement, a brief look at the previous initiative and workbook designed to promote participant involvement, and explores why these interventions were not successful. The report presents the findings of the PFV-WC indicating that self-stigma, stigma within the Agency, and social stigma are the greatest barriers to involvement in the Agency and advises that a focus on the key themes of education, connection, diversity of roles, skills and assets, and family, will enable the Agency to address stigma to create a community where participants feel empowered to become involved. The findings of the PFV-WC also indicate that the mental health language and terminology is problematic and that work must be done to ensure that participants, family members, staff, and Board members are using the same definitions. The findings of the PFVC indicate funding must be established to support an on-going project to support involvement, significant time should be allocated, people experiencing mental illness must have supported space for contributions, and that materials should be accessible and presented in multiple formats. The report also highlights instances of successful participant and family involvement. In conclusion, short and long-term recommendations specific to the CMHA-VF are presented to promote and sustain participant and family member involvement.
title: Ð­ÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÑÑÐ²Ð° Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ ÑÐµÑÐ¾Ðº Ð°ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: ÐÑÐ·ÑÐ¼Ð¸Ð½, ÐÐ²Ð°Ð½
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: Ð¡ÑÑÐ¾Ð¸ÑÐµÐ»ÑÑÑÐ²Ð¾
ÐÑÐ¼Ð°ÑÑÑÐ°
Ð¡ÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½ÑÐµ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ñ
Ð°ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
Ð°ÑÐ¼Ð°ÑÑÑÐ½Ð°Ñ ÑÐµÑÐºÐ°

description: Ð Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ¾Ð¹ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ð¸ ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÐµÑÑÑ Ð²Ð¾Ð¿ÑÐ¾Ñ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÑÑÐ²Ð° Ð¿ÑÐ¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ð¸ ÑÐµÑÐ¾Ðº Ð°ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð·Ð°Ð²Ð¾Ð´ÑÐºÐ¾Ð³Ð¾ Ð¸Ð·Ð³Ð¾ÑÐ¾Ð²Ð»ÐµÐ½Ð¸Ñ Ð¿ÑÐ¸ Ð°ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ð¸ Ð¿ÐµÑÐµÐºÑÑÑÐ¸Ð¹ Ð·Ð´Ð°Ð½Ð¸Ð¹. Ð Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ð¸ Ð¿ÑÐ¾Ð´ÐµÐ¼Ð¾Ð½ÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½ ÑÐ°ÑÑÐµÑ Ð¸ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ ÑÐ¿Ð¾ÑÐ¾Ð±Ð¾Ð² Ð°ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÐµÑÐµÐºÑÑÑÐ¸Ñ Ð¾Ð´Ð½Ð¾Ð³Ð¾ Ð·Ð´Ð°Ð½Ð¸Ñ. Ð ÑÐ¾Ð´Ðµ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ»Ð¸ ÑÐ°ÑÑÑÐ¸ÑÐ°Ð½Ñ Ð¸ ÑÐ¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ñ Ð¿ÐµÑÐµÐºÑÑÑÐ¸Ñ Ð´Ð»Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ Ð·Ð´Ð°Ð½Ð¸Ð¹ Ð¸Ð¼ÐµÑÑÐ¸Ðµ ÑÐ°Ð·Ð½ÑÐµ Ð¿Ð»Ð¾ÑÐ°Ð´Ð¸ Ð¿ÐµÑÐµÐºÑÑÑÐ¸Ð¹, ÑÑÐ°Ð¶Ð½Ð¾ÑÑÑ Ð¸ Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ð¸Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ ÑÐ°Ð±Ð¾ÑÑ Ð²ÑÑÐ²Ð»ÐµÐ½Ð° ÑÐµÐ»ÐµÑÐ¾Ð¾Ð±ÑÐ°Ð·Ð½Ð¾ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐµÑÐ¾Ðº Ð°ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð·Ð°Ð²Ð¾Ð´ÑÐºÐ¾Ð³Ð¾ Ð¸Ð·Ð³Ð¾ÑÐ¾Ð²Ð»ÐµÐ½Ð¸Ñ Ð² ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÑÑÐ²Ðµ.
description: The master's thesis reviewed the issue of increasing the efficiency of construction by using prefabricated reinforcement meshes for reinforcing floor slabs of buildings. The thesis demonstrated the calculation and comparison of ways of reinforcing the overlap of one building. The slabs of different buildings with different areas, the number of storeys and purpose of usewere designed and calculated. As a result of the work theexpediency of reinforcement with prefabrication meshes in construction was educed.
Additional file 1 of Loss of glucosylceramide synthase impairs the growth and virulence of Fusarium oxysporum f. sp. cubense
Creators: name: Wang, Jian
name: Zhang, Kun
name: Huang, Li-Qun
name: Bao, He-Nan
name: Hai, Na
name: Yang, Yu-Bing
name: Liu, Si-Wen
name: Li, Chun-Yu
name: Yao, Nan
Publisher: name: figshare
Year: 2022
Subjects: subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Sequence identity of FocGCS with GCS from other organisms. Table S2. PCR primers used in this study. Table S4. Mass spectrometer parameters used for MRM scanning of sphingolipid species.
Under the Influence: How Viewing Extreme Partying and Drinking on Social Media Shapes Group Perceptions
Creators: name: Giguère, Benjamin
name: Davis, Joshua
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: social media
subject: prototypes
subject: social norms
subject: alcohol consumption

description: Social media use is omnipresent among college and university students. The platforms allow students to view a range of content, including risk-taking forms of alcohol use. The current study investigated how exposure to social media shapes the perceptions of the prototypical member of a student’s social group and of how normal alcohol consumption is among their social group. A 2020, pre-registered three time -point experiment was conducted that measured 208 (M age = 18.85, SD =1.94; 160 female) participant ’s partying/drinking prototypes along with their perceived normative support of alcohol consumption. At Time 2, participants were randomly assigned to one of four conditions, three video conditions and one non-video condition, with one video condition displaying extreme risk -taking drinking behavior. A 4 (Condition) X 3 (Time) Mixed ANOVA revealed that within the risk -taking drinking condition, participants used more pro -alcohol consumption words to describe the typical ingroup member and perceived an increase in normative support of alcohol consumption. Exploratory analyses are also presented . Implications of this study suggest that extreme risk taking content from social media may pose barriers to developing social norms interventions to address problematic university and college student drinking.
Evolution of Magnetic Fields in High Mass Star Formation: SMA dust polarization image of the UCHII region G5.89-0.39
Creators: name: Tang, Ya-Wen
name: Ho, Paul T. P.
name: Girart, Josep Miquel
name: Rao, Ramprasad
name: Koch, Patrick
name: Lai, Shih-Ping
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We report high angular resolution (3") Submillimeter Array (SMA) observations of the molecular cloud associated with the Ultra-Compact HII region G5.89-0.39. Imaged dust continuum emission at 870 micron reveals significant linear polarization. The position angles (PAs) of the polarization vary enormously but smoothly in a region of 2x10^4 AU. Based on the distribution of the PAs and the associated structures, the polarized emission can be separated roughly into two components. The component "x" is associated with a well defined dust ridge at 870 micron, and is likely tracing a compressed B field. The component "o" is located at the periphery of the dust ridge and is probably from the original B field associated with a pre-existing extended structure. The global B field morphology in G5.89, as inferred from the PAs, is clearly disturbed by the expansion of the HII region and the molecular outflows. Using the Chandrasekhar-Fermi method, we estimate from the smoothness of the field structures that the B field strength in the plane of sky can be no more than 2-3 mG. We then compare the energy densities in the radiation, the B field, and the mechanical motions as deduced from the C^17O 3-2 line emission. We conclude that the B field structures are already overwhelmed and dominated by the radiation, outflows, and turbulence from the newly formed massive stars.
description: 35 pages, 8 figures. Accepted by ApJ
Immediate early genes regulation in rat cerebellar cortex during long-term synaptic plasticity induction
Creators: name: Polimeni, Mariarosa
name: Gandolfi, Daniela
name: Cerri, Silvia
name: Mapelli, Jonathan
name: Tritto, Simona
name: Alloni, Maurizio
name: Armentero, Marie-Therese
name: Blandini, Fabio
name: D’Angelo, Egidio
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011
Subjects: immediate early genes; long-term synaptic plasticity; cerebellar cortex; VSD imaging; in situ hybridization; immunohystochemistry

description: The cerebellum is one of the brain areas involved in learning and memory formation. Long-term synaptic plasticity is thought to play a pivotal role in supporting these functions. Moreover Immediate Early Genes (IEGs) expression and de novo protein synthesis and/or modification have been strictly associated with maintenance of Long-Term Potentiation (LTP) as well as memory consolidation and storage. Two highly conserved signalling cascades, PKA and MAPK, seem to be involved in early- to late-LTP conversion; both pathway can activate CREB transcription factor through phosphorylation and P-CREB has been suggested to initiate the protein synthesis leading to late-LTP induction. The transcription factor c-fos is known to be rapidly and transiently induced in the Nervous System by a variety of stimuli and is thought to be directly involved in processes of neuronal plasticity including LTP. We used rat parasagittal cerebellar slices as a model system in which specific patterns of stimulation delivered to the mossy fibers can induce both Long-Term Potentiation and Long-Term Depression (LTD), depending on local inhibition and other regulating factors. Using Voltage Sensitive Dye (VSD) imaging we obtained high-resolution maps of the spatial distribution of LTP/LTD induced from a Teta Burst Stimulus (TBS) application. Control and stimulated slices were fixed at different times from the TBS application and processed for in situ hybridization or immunohystochemistry in order to detect IEGs mRNA expression patterns and protein expression/modifications. The expression pattern of c-fos and CREB mRNAs and their protein distribution and/or phosphorylation were then correlated with LTP/LTD maps generated by VSD imaging. Preliminary data indicate a significant increase of P-CREB in the granular layer suggesting that CREB phosphorylation is induced as early as 15 minutes post TBS application. In situ hybridization experiments indicate a good correlation between c-fos and CREB mRNAs up-regulation and LTP distribution at 120 minutes post TBS. At the protein level, the comparison of immunofluorescence signals and VSD immaging data indicate a clear correlation between c-Fos and P-CREB distribution and synaptic plasticity patterns. We are planning further experiments to confirm these data and to test our experimental system in the presence of drugs that could interfere with the transcription, translation or post-translational protein regulation.
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011
title: ÐÑÐºÑÑÑÐ¸Ðµ Ð¸Ð½ÑÐµÑÐ½ÐµÑ-Ð¼Ð°Ð³Ð°Ð·Ð¸Ð½Ð°: Ð¿ÑÐ°Ð²Ð¾Ð²ÑÐµ Ð²Ð¾Ð¿ÑÐ¾ÑÑ, Ð±ÑÑ Ð³Ð°Ð»ÑÐµÑÑÐºÐ¸Ð¹ Ð¸ Ð½Ð°Ð»Ð¾Ð³Ð¾Ð²ÑÐ¹ ÑÑÐµÑ (Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ ÐÐÐ Â«ÐÐ²ÑÐ¾Ð¿Ð°Â»)
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ°ÑÐºÐ¾Ð²Ð° , ÐÐºÐ°ÑÐµÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: Ð¸Ð½ÑÐµÑÐ½ÐµÑ-Ð¼Ð°Ð³Ð°Ð·Ð¸Ð½
Ð¸Ð½ÑÐµÑÐ½ÐµÑ ÐºÐ¾Ð¼Ð¼ÐµÑÑÐ¸Ñ
ÑÐ¿Ð¾ÑÐ¾Ð±Ñ Ð¾Ð¿Ð»Ð°ÑÑ
online store
Internet commerce
payment methods

description: Ð Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¿ÑÐ¸Ð²ÐµÐ´ÐµÐ½Ñ Ð¾Ð±ÑÐ¸Ðµ ÑÐ²ÐµÐ´ÐµÐ½Ð¸Ñ Ð¾Ð± ÐÐÐ Â«ÐÐ²ÑÐ¾Ð¿Ð°Â». ÐÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ð° Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²ÐµÐ½Ð½Ð°Ñ ÑÑÑÑÐºÑÑÑÐ° Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¿ÑÐ¸Ð²ÐµÐ´ÐµÐ½Ñ Ð¸ Ð¿ÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ñ ÑÐµÑÐ½Ð¸ÐºÐ¾-ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ðµ, ÑÐ¸Ð½Ð°Ð½ÑÐ¾Ð²ÑÐµ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»Ð¸ Ð·Ð° 2013-2015 Ð³Ð³. Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸, Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· Ð²ÐµÐ´ÐµÐ½Ð¸Ñ Ð±ÑÑÐ³Ð°Ð»ÑÐµÑÑÐºÐ¾Ð³Ð¾ Ð¸ Ð½Ð°Ð»Ð¾Ð³Ð¾Ð²Ð¾Ð³Ð¾ ÑÑÐµÑÐ° Ð¿ÑÐ¸ Ð¾ÑÐºÑÑÑÐ¸Ð¸ Ð¸Ð½ÑÐµÑÐ½ÐµÑ-Ð¼Ð°Ð³Ð°Ð·Ð¸Ð½Ð° ÐÐÐ Â«ÐÐ²ÑÐ¾Ð¿Ð°Â». ÐÑÐ¸Ð²ÐµÐ´ÐµÐ½Ð¾ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¾Ðµ Ð¾Ð±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð½ÑÑ Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ð¹.
description: The bachelor paper presents an overview of the company âEuropeâ. Presented production structure of the enterprise, as well as listed and analyzed the technical, economic, financial indicators for 2013-2015 the organization, the analysis of accounting and tax accounting at the opening of an online store Ltd. âEuropeâ. Powered feasibility study of the proposed activities.
Additional file 11 of Stage-specific expression of an odorant receptor underlies olfactory behavioral plasticity in Spodoptera littoralis larvae
Creators: name: Revadi, Santosh V.
name: Giannuzzi, Vito Antonio
name: Rossi, Valeria
name: Hunger, Gert Martin
name: Conchou, Lucie
name: Rondoni, Gabriele
name: Conti, Eric
name: Anderson, Peter
name: Walker, William B.
name: Jacquin-Joly, Emmanuelle
name: Koutroumpa, Fotini
name: Becher, Paul G.
Publisher: name: figshare
Year: 2021
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Additional file 11: Table S5. List of chemical compounds used in the electrophysiological recordings.
Additional file 1 of Chronic exposure to perfluorohexane sulfonate leads to a reproduction deficit by suppressing hypothalamic kisspeptin expression in mice
Creators: name: Yin, Xiaorui
name: Di, Tingting
name: Cao, Xinyuan
name: Liu, Zhengnan
name: Xie, Jingyan
name: Zhang, Suyun
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Additional file 1: S-Fig. 1. Effect of PFHxS exposure on reference genes (GAPDH) for the RT-qPCR. Bar graphs show levels of cycle threshold (Ct) values. (n = 6/group, one-way ANOVA). S-Fig. 2. Levels of T4 in the control and PFHxS mice. Bar graphs show levels of T4. (n = 6/group, Student’s t-test).
title: ÐÐ¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ Ð¿Ð¾ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ñ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½ÑÑ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð²
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: ÐÑÑÐ¾ÑÐµÐ½ÐºÐ¾, ÐÐ»ÐµÐºÑÐ°Ð½Ð´Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: ÑÑÑÐ¾Ð¹Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ñ
ÑÐ¸ÑÑÐµÐ¼Ð½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð·
Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
Ð³ÑÐ°Ñ
ÑÐ¸ÑÑÐµÐ¼Ñ Ð¼Ð°ÑÑÐ¾Ð²Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ»ÑÐ¶Ð¸Ð²Ð°Ð½Ð¸Ñ

description: Ð¦ÐµÐ»Ñ ÑÐ°Ð±Ð¾ÑÑ: Ð¾Ð¿ÑÐ¸Ð¼Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°ÑÑ Ð¿ÑÐ¾ÑÐµÑÑ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð° ÑÑÑÐ¾Ð¹Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð² Ñ Ð¿ÑÐ¸Ð²Ð»ÐµÑÐµÐ½Ð¸ÐµÐ¼ Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹ ÑÐµÐ¾ÑÐ¸Ð¸ Ð¡ÐÐ.
ÐÐ±ÑÐµÐºÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ: Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð¾ ÑÐ¸Ð»Ð¸ÐºÐ°ÑÐ½Ð¾Ð³Ð¾ ÐºÐ¸ÑÐ¿Ð¸ÑÐ°.
ÐÑÐµÐ´Ð¼ÐµÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ: Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹ ÑÐµÐ¾ÑÐ¸Ð¸ Ð¡ÐÐ Ð´Ð»Ñ Ð¾Ð¿Ð¸ÑÐ°Ð½Ð¸Ñ Ð¸ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²ÐµÐ½Ð½ÑÑ Ð¿ÑÐ¾ÑÐµÑÑÐ¾Ð².
Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ ÑÐ°Ð±Ð¾ÑÑ: ÐÐ¾ÑÑÑÐ¾ÐµÐ½Ñ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²ÐµÐ½Ð½Ð¾Ð¹ ÑÑÑÑÐºÑÑÑÑ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ, Ð²ÑÐ¿ÑÑÐºÐ°ÑÑÐµÐ³Ð¾ ÑÐ¸Ð»Ð¸ÐºÐ°ÑÐ½ÑÐ¹ ÐºÐ¸ÑÐ¿Ð¸Ñ, Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÑÑÐ¸Ðµ Ð¾Ð¿ÑÐ¸Ð¼Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°ÑÑ Ð¿ÑÐ¾ÑÐµÑÑ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð° Ð¸ ÑÐ²ÐµÐ»Ð¸ÑÐ¸ÑÑ Ð¾Ð±ÑÑÐ¼ Ð²ÑÐ¿ÑÑÐºÐ°ÐµÐ¼Ð¾Ð¹ Ð¿ÑÐ¾Ð´ÑÐºÑÐ¸Ð¸.
title: Ð¢ÐµÑ Ð½Ð¸ÐºÐ° ÑÐ±Ð¾ÑÐºÐ¸ Ð¸ ÑÐ²Ð°ÑÐºÐ¸ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¸ ÐÐ½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ ÑÐ¸ÑÐ°
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: Ð£Ð³Ð»Ð¾Ð², Ð¡ÐµÑÐ³ÐµÐ¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ñ ÑÐ²Ð°ÑÐºÐ¸
Ð¼ÐµÑ Ð°Ð½Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð°Ñ ÑÐ²Ð°ÑÐºÐ°
ÑÐµÐ¶Ð¸Ð¼ ÑÐ²Ð°ÑÐºÐ¸
ÐºÐ¾Ð½ÑÑÐ¾Ð»Ñ ÐºÐ°ÑÐµÑÑÐ²Ð°

description: Ð Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ð° ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ñ ÑÐ±Ð¾ÑÐºÐ¸ Ð¸ ÑÐ²Ð°ÑÐºÐ¸ ÐºÐ¾Ð½-ÑÑÑÑÐºÑÐ¸Ð¸ Â«ÐÐ½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½ÑÐ¹ ÑÐ¸ÑÂ». Ð Ð°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð²Ð¾Ð¿ÑÐ¾ÑÑ Ð²ÑÐ±Ð¾ÑÐ° ÑÐ¿Ð¾ÑÐ¾Ð±Ð° ÑÐ²Ð°ÑÐºÐ¸, Ð²ÑÐ±ÑÐ°Ð½Ñ ÑÐ²Ð°ÑÐ¾ÑÐ½ÑÐµ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ñ Ð¸ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ. ÐÐ°Ð½Ñ ÑÑÐµÐ±Ð¾Ð²Ð°Ð½Ð¸Ñ Ðº ÐºÐ¾Ð½ÑÑÐ¾Ð»Ñ ÐºÐ°ÑÐµÑÑÐ²Ð° ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¸.
Nitric oxide and human sperm motility: an immunohistochemical study
Creators: name: Salvolini, Eleonora
name: Lucarini, Guendalina
name: Buldreghini, Eddi
name: Pugnaloni, Armanda
name: Ferretti, Concetta
name: Balercia, Giancarlo
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011
Subjects: spermatozoa; asthenozoospermia; nitric oxide synthase; citrulline; nitrotyrosine; immunohistochemistry

description: Defective sperm function is a common cause of human male infertility. Human spermatozoa are very susceptible to oxidative stress, probably because they contain high levels of polyunsaturated fatty acids and are exposed to ROS produced by contaminating neutrophils or by the spermatozoa themselves. In addition, due to the cytoplasm scarcity, they lack an adequate reserve of antioxidant enzymes. It has been previously shown that human spermatozoa produce nitric oxide (NO) as well as superoxide anion and consequently peroxynitrite, which can rapidly react with proteins, lipids, and nucleic acids. NO is a short-lived free radical produced by three isoforms of NO synthase (NOS): endothelial (eNOS), neuronal (nNOS), and inducible (iNOS), which are responsible for the conversion of L-arginine to L-citrulline and NO. NO plays an important role in sperm physiology, although at high concentrations it could lead to cytotoxicity accompanied by decreased sperm motility. In recent studies it has been evidenced the presence of a significant negative linear correlation between NO concentration and sperm motility, as well as between peroxynitrite production and the kinetic features of spermatozoa. It has been previously demonstrated that the spermatozoa of fertile men express both eNOS and nNOS, which appear to be involved in sperm motility, metabolism, capacitation and acrosome reaction. However, the specific role of NOS isoforms in gametes is not well understood, even if iNOS seems to negatively affect the sperm function through the production of large amounts of NO, and consequently the nitration of protein tyrosine by peroxynitrite. The aim of the present study was to assess the presence and localization of NOS isoforms in human spermatozoa isolated from controls and asthenozoospermic infertile patients, by means of immunohistochemical techniques, in order to characterize the pattern of NOS expression and to evaluate the correlation with sperm function. In addition we studied the immunoexpression of citrulline, to achieve the microscopic visualization of NOS catalytic activity, and nitrotyrosine, since the protein tyrosine nitration represents a shift from the physiological role of NO toward pathogenetic pathways. The main results of our study are that the immunohistochemical expression of constitutive NOS isoforms is lower in the asthenozoospermic group, while the immunoexpression of iNOS and nitrotyrosine is higher in comparison with normozoospermic fertile subjects, thus suggesting a possible pathogenetic role of NO in the reduction of sperm motility.
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011
Designing for a Changing Climate : Adapting Vancouver`s Northeast False Creek to Higher Seas and Stronger Storms
Creators: name: Keating, Jeremy
Publisher: name: The University of British Columbia
Year: 2016

description: In an effort to address the coming threat of climate change, the goal of this project is to use best practices from around the world to inform the design of the Northeast False Creek area of Vancouver, B.C. (herein referred to as “NEFC”). The timing of this project, corresponding with the City of Vancouver’s initial planning stages for the area, provides a rare opportunity to positively impact how the city is designed and built, with an emphasis on looking forward towards a world impacted by climate change. By addressing the future threats of sea level rise and increased stormwater management issues, the designs presented in this project aim to aid the City of Vancouver in moving into the future sustainably, by considering more than just traditional hard infrastructure when addressing water.
The effect of spatial transverse coherence property of a thermal source on Ghost imaging and Ghost imaging via compressive sampling
Creators: name: Gong, Wenlin
name: Han, Shensheng
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Both ghost imaging (GI) and ghost imaging via compressive sampling (GICS) can nonlocally image an object. We report the influence of spatial transverse coherence property of a thermal source on GI and GICS and show that, using the same acquisition numbers, the signal-to-noise ratio (SNR) of images recovered by GI will be reduced while the quality of reconstructed images will be enhanced for GICS as the spatial transverse coherence lengths located on the object plane are decreased. Differences between GI and GICS, methods to further improve the quality and image extraction efficiency of GICS, and its potential applications are also discussed.
description: 7 pages, 5 figures
New route for Tizanidine administration: a pharmacokinetics and light microscope autoradiography study
Creators: name: Tayebati, Seyed Khosrow
name: Nwankwo, Innocent Ejike
name: Borsa, Massimiliano
name: Traini, Enea
name: Amenta, Francesco
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011

description: Spasticity could represent a complication of several central nervous system (CNS) disorders. Multiple sclerosis and painful paroxysmal syndromes (e.g. trigeminal neuralgia) are pathologies in which anti-spastic drugs are used to a greater extent . Baclofen, tizanidine (TIZ), benzodiazepines, dantrolene, and, more recently, gabapentin are the pharmacological agents more widely used. Baclofen, TIZ, benzodiazepines, gabapentin, clonidine but not dantrolene are active on CNS. The  alpha2 adrenoceptor agonist TIZ is one of the most effective and largely used  anti-spastic drugs. Oral treatment is the only route of anti-spastics administration, although it may cause problems of bioavailability and/or compliance in spastic patients with impaired deglutition. This study was designed to assess the possibility of develop a new  route of administration of TIZ and to identify its targets in the spinal cord. New Zealand rabbits were treated with oral (OR , n=6), intramuscular (IM, n=6) or  intranasal (IN, n=6) TIZ (3.2 mg/kg/day). Plasma concentration was measured by HPLC on samples collected at 0, 30, 60, 90, 120 and 480 min after treatment. Curves of average concentrations of TIZ vs. time were constructed. In plasma, TIZ reached a peak between 45-65 min after administration. Cmax was in the range of 268.33–1213.64 ng/ml for IM treatment, of 73.95–135.92 ng/ml for IN treatment and of 16.86–857.25 ng/ml for OR treatment. After pharmacokinetic studies, different spinal cord tracts were removed and used for radioligand binding assay and autoradiography. Using [3H]-RX821002 ([3H]-RX) (0.1-14nM), the Kd and Bmax for every spinal cord segment were calculated. The non-specific binding was obtained with 100µM of (-)-epinephrine. [3H]-RX sites were accumulated in the superficial laminae of dorsal horn. Dense [3H]-RX binding in control was seen over the superficial dorsal horn (laminae I-II) and centrally located lamina X. The ventral horn showed moderate levels of binding. [3H]-RX was displaced after TIZ treatment using different administration routes. The heaviest accumulation of silver grains (lowest displacement of TIZ) occurred after OR administration of the compound, the lowest after IM administration. These results suggest that both IM and IN administration of TIZ may represent routes of administration of the drug alternative to the OR one.
Considering predictable adverse effects of IM treatment, the IN administration could represent the elective route to administrate this kind of drugs.
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011
Additional file 1 of Stage-specific expression of an odorant receptor underlies olfactory behavioral plasticity in Spodoptera littoralis larvae
Creators: name: Revadi, Santosh V.
name: Giannuzzi, Vito Antonio
name: Rossi, Valeria
name: Hunger, Gert Martin
name: Conchou, Lucie
name: Rondoni, Gabriele
name: Conti, Eric
name: Anderson, Peter
name: Walker, William B.
name: Jacquin-Joly, Emmanuelle
name: Koutroumpa, Fotini
name: Becher, Paul G.
Publisher: name: figshare
Year: 2021
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Additional file 1: Table S1. BUSCO scores for transcriptomes assembly completeness: Assessment of Spodoptera littoralis larval transcriptomes assembly completeness using the Benchmarking BUSCO tool performed against insecta_obd9 database consisting of 1,658 BUSCOs.
title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ Ð½Ð°Ð¿ÑÑÐ¶ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ñ Ð½Ð° Ð±Ð¸Ð¾Ð¼ÐµÑ Ð°Ð½Ð¸ÐºÑ Ð¿ÑÐ¾Ð´Ð¾Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ° Ð°ÐºÑÐ¾Ð½Ð°
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: Ð¥Ð°ÑÐ±Ð°, ÐÐ°Ð»ÐµÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÐÐ¸Ð¾Ð¼ÐµÑ Ð°Ð½Ð¸ÐºÐ°
ÐÐµÐ¹ÑÐ¾Ð½Ñ
Ð½ÐµÑÐ²Ð½Ð°Ñ ÑÐ¸ÑÑÐµÐ¼Ð°

description: Ð Ð½Ð°ÑÑÐ¾ÑÑÐµÐ¹ ÑÐ°Ð±Ð¾ÑÐµ ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÐµÑÑÑ Ð±Ð¸Ð¾Ð¼ÐµÑÐ°Ð½Ð¸ÐºÐ° Ð¿ÑÐ¾Ð´Ð¾Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ° Ð°ÐºÑÐ¾Ð½Ð°. ÐÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ð° ÑÐµÑÐ¼Ð¾Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¸ Ð¾Ð±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð½Ð°Ñ Ð¾Ð´Ð½Ð¾Ð¼ÐµÑÐ½Ð°Ñ Ð¼Ð¾Ð´ÐµÐ»Ñ ÑÐ¾ÑÑÐ° Ð² ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¿Ð¾Ð´Ð²Ð¾Ð´Ð° Ð²ÐµÑÐµÑÑÐ²Ð° Ðº ÐºÐ¾Ð½ÑÑ Ð°ÐºÑÐ¾Ð½Ð°. ÐÑÐ¸Ð²Ð¾Ð´Ð¸ÑÑÑ Ð²ÑÐ²Ð¾Ð´ Ð²ÑÑÐ°Ð¶ÐµÐ½Ð¸Ñ ÐºÐ¾Ð½ÑÐ¸Ð³ÑÑÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ¸Ð»Ñ ÑÐ¿ÑÐ°Ð²Ð»ÑÑÑÐµÐ¹ ÑÐ¾ÑÑÐ¾Ð¼ Ð¸ ÑÐ¾ÑÐ¼ÑÐ»Ð¸ÑÑÐµÑÑÑ ÐºÐ¸Ð½ÐµÑÐ¸ÑÐµÑÐºÐ¾Ðµ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ Ð² Ð²Ð¸Ð´Ðµ ÑÐ²ÑÐ·Ð¸ ÑÐºÐ¾ÑÐ¾ÑÑÐ¸ ÑÐ¾ÑÑÐ° Ð°ÐºÑÐ¾Ð½Ð° Ñ ÐºÐ¾Ð½ÑÐ¸Ð³ÑÑÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ¸Ð»Ð¾Ð¹, Ð¿Ð¾Ð·Ð²Ð¾Ð»Ð¸Ð²ÑÐµÐµ Ð¾Ð¿Ð¸ÑÐ°ÑÑ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð½Ð°Ð¿ÑÑÐ¶ÐµÐ½Ð¸Ð¹ ÑÐµÑÐµÐ· ÐºÐ¾Ð½ÑÐ¸Ð³ÑÑÐ°ÑÐ¸Ð¾Ð½Ð½ÑÑ ÑÐ¸Ð»Ñ. ÐÑÐ¸Ð²ÐµÐ´ÐµÐ½Ð¾ ÑÐµÑÐµÐ½Ð¸Ðµ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ Ð´Ð¸ÑÑÑÐ·Ð¸Ð¾Ð½Ð½Ð¾-ÑÑÐ°Ð½ÑÐ¿Ð¾ÑÑÐ½Ð¾Ð¹ Ð¿Ð¾Ð´Ð°ÑÐ¸ Ð²ÐµÑÐµÑÑÐ²Ð° Ð¿ÑÐ¸ ÑÐ¾ÑÑÐµ Ð°ÐºÑÐ¾Ð½Ð° Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð²ÐµÐ»Ð¸ÑÐ¸Ð½Ñ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ° ÑÑÐ°Ð½ÑÐ¿Ð¾ÑÑÐ° Ð½Ð° ÐºÐ¸Ð½ÐµÑÐ¸ÐºÑ ÑÐ¾ÑÑÐ°. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¾ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ Ð¿Ð¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ Ð°ÐºÑÐ¾Ð½Ð° Ð² ÑÐ¿ÑÑÐ³Ð¾Ð¹ Ð¸ Ð²ÑÐ·ÐºÐ¾-ÑÐ¿ÑÑÐ³Ð¾Ð¹ ÑÐµÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¼Ð¾Ð´ÐµÐ»ÑÑ. ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð²ÐµÐ»Ð¸ÑÐ¸Ð½Ñ ÐºÐ¾ÑÑÑÐ¸ÑÐ¸ÐµÐ½ÑÐ° Ð²ÑÐ·ÐºÐ¾ÑÑÐ¸ Ð½Ð° ÑÐ´Ð»Ð¸Ð½ÐµÐ½Ð¸Ðµ Ð°ÐºÑÐ¾Ð½Ð°. ÐÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð¼ÐµÑÐ°Ð½Ð¸ÑÐµÑÐºÐ¸Ñ Ð½Ð°Ð¿ÑÑÐ¶ÐµÐ½Ð¸Ð¹ Ð½Ð° ÐºÐ¸Ð½ÐµÑÐ¸ÐºÑ ÑÐ¾ÑÑÐ° Ð°ÐºÑÐ¾Ð½Ð°.
Characterization and gene expression of cancer stem cells grown as sarcospheres from human primary sarcomas
Creators: name: Tirino, Virginia
name: Paino, Francesca
name: Desiderio, Vincenzo
name: Altucci, Lucia
name: Papaccio, Gianpaolo
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011
Subjects: cancer stem cells; CD133; sarcospheres; gene expression

description: This study aimed to identify, isolate and characterize cancer stem cells from human primary sarcomas. We performed cytometric analyses for stemness and differentiation antigens including CD29, CD34, CD44, CD90, CD117 and CD133 on 21 human primary sarcomas on the day of surgery. From sarcoma biopsies, we obtained two chondrosarcoma stabilized cell lines and two osteosarcoma stabilized cell lines on which spheres formation, side population profile, stemness gene expression and in vivo and in vitro assays were performed. On a chondrosarcoma cell line, the whole genoma microarray analyses were performed (sarcospheres versus adherent cells). All samples expressed the CD133, CD44 and CD29 markers. We selected a CD133+ subpopulation from stabilized cell lines that displayed the capacity to grow as sarcospheres able to initiate and sustain tumour growth in NOD/SCID mice, to express stemness genes including OCT3/4, Nanog, Sox2 and Nestin and to differentiate into mesenchymal lineages. Microarray analyses pointed out a huge gene expression difference between sarcospheres and adherent cells. About 2000 genes, including ones related to cell cycle, stemness and epigenetic regulation, resulted to be very differentially expressed in the two population considered. With signed ratio of 2,806 genes were over-expressed and 1,029 under-expressed on sarcospheres when compared with adherent cells. The most highly overexpressed gene were thioredoxin interacting protein (fold +25) that modulates the cellular redox state, growth differentiation factor 15 (fold +10), member of the TGF–β superfamily , histone cluster 1, H2ad (fold +9) and solute carrier family 2 member 14 that facilitate glucose transport (fold +8,9). Our findings evidence the existence of cancer stem cells in human primary bone sarcomas and highlight CD133 as pivotal marker for identification of these cells. This may be of primary importance in the development of new therapeutic strategies and new prognostic procedures against these highly aggressive and metastatic tumours.
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011
title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼Ð° Ð¸ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð³Ð¾ ÑÑÐµÐ´ÑÑÐ²Ð° Ð²ÑÑÐ¾ÐºÐ¾Ð½Ð°Ð´ÐµÐ¶Ð½Ð¾Ð¹ ÐºÐ»Ð°ÑÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ Ð¾Ð±ÑÐµÐºÑÐ¾Ð² Ð¿Ð¾ Ð¸Ð·Ð¾Ð±ÑÐ°Ð¶ÐµÐ½Ð¸ÑÐ¼ Ñ Ð½ÐµÑÐºÐ¾Ð»ÑÐºÐ¸Ñ ÑÐ¾ÑÐµÐº.
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ°Ð½ÑÐµÐ½ÐºÐ¾, ÐÐ»ÐµÐ½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: ÐºÐ»Ð°ÑÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ñ
Ð¼Ð°ÑÐ¸Ð½Ð½Ð¾Ðµ Ð¾Ð±ÑÑÐµÐ½Ð¸Ðµ
Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð°Ñ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ñ

description: ÐÐ±ÑÐµÐºÑÐ¾Ð¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ²Ð»ÑÑÑÑÑ Ð¼ÐµÑÐ¾Ð´Ñ Ð¸ Ð·Ð°Ð´Ð°ÑÐ¸ ÑÐ°ÑÐ¿Ð¾Ð·Ð½Ð°Ð²Ð°Ð½Ð¸Ñ Ð¾Ð±ÑÐ°Ð·Ð¾Ð² Ð¿ÑÐ¸Ð¼ÐµÐ½Ð¸ÑÐµÐ»ÑÐ½Ð¾ Ðº ÑÐ°ÑÐ¿Ð¾Ð·Ð½Ð°Ð²Ð°Ð½Ð¸Ñ Ð¼ÑÑÐ¾ÑÐ°. Ð¦ÐµÐ»Ñ ÑÐ°Ð±Ð¾ÑÑ - ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ðµ Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼Ð° Ð¸ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð³Ð¾ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ° Ð´Ð»Ñ ÐºÐ»Ð°ÑÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÐ¸Ð¿Ð° Ð¾Ð±ÑÐµÐºÑÐ¾Ð² Ð¸ ÑÐ°ÑÐ¿Ð¾Ð·Ð½Ð°Ð²Ð°Ð½Ð¸Ñ Ð´Ð°Ð½Ð½ÑÑ Ð¾Ð±ÑÐµÐºÑÐ¾Ð² Ð¿Ð¾ Ð¸Ð·Ð¾Ð±ÑÐ°Ð¶ÐµÐ½Ð¸ÑÐ¼ Ñ Ð½ÐµÑÐºÐ¾Ð»ÑÐºÐ¸Ñ ÑÐ¾ÑÐµÐº. Ð Ð¿ÑÐ¾ÑÐµÑÑÐµ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ»Ð¸ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ñ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÐµ Ð¿Ð¾Ð´ÑÐ¾Ð´Ñ Ðº ÑÐ°ÑÐ¿Ð¾Ð·Ð½Ð°Ð²Ð°Ð½Ð¸Ñ Ð¾Ð±ÑÐ°Ð·Ð¾Ð². Ð Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð¼ ÑÑÐµÐ´ÑÑÐ²Ðµ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·ÑÑÑÑÑ ÑÐµÐ³Ð¼ÐµÐ½ÑÐ°ÑÐ¸Ñ, Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð½Ð°Ñ Ð½Ð° ÑÐ°Ð·ÑÐµÐ·Ðµ Ð³ÑÐ°ÑÐ°, Ð´ÐµÑÐºÑÐ¸Ð¿ÑÐ¾ÑÑ Ð³ÑÐ°Ð½Ð¸Ñ Ð¸ Ð¼Ð°ÑÐ¸Ð½Ð½Ð¾Ðµ Ð¾Ð±ÑÑÐµÐ½Ð¸Ðµ. ÐÑÐ»Ð¾ ÑÐ¾Ð·Ð´Ð°Ð½Ð¾ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ðµ ÑÑÐµÐ´ÑÑÐ²Ð¾, Ð²ÐºÐ»ÑÑÐ°ÑÑÐµÐµ Ð¼Ð¾Ð´ÑÐ»Ð¸ ÐºÐ»Ð°ÑÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸, Ð¾Ð±ÑÑÐµÐ½Ð¸Ñ ÐºÐ»Ð°ÑÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¾ÑÐ° Ð¸ Ð²ÑÐ¿Ð¾Ð¼Ð¾Ð³Ð°ÑÐµÐ»ÑÐ½ÑÐµ Ð¼Ð¾Ð´ÑÐ»Ð¸. ÐÑÐµÐ½ÐºÐ° ÐºÐ°ÑÐµÑÑÐ²Ð° Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼Ð¾Ð² Ð¿ÑÐ¸ Ð¾ÑÐ½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾ Ð½ÐµÐ±Ð¾Ð»ÑÑÐ¾Ð¹ Ð²ÑÐ±Ð¾ÑÐºÐµ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð»Ð° Ð½Ð°Ð´ÐµÐ¶Ð½Ð¾ÑÑÑ 67,6%.
Cadmium and myalgic encephalomyelitis/chronic fatigue syndrome; application of transcranial sonography to the study of cadmium-induced neuronal damage
Creators: name: Morucci, Gabriele
name: Gulisano, Massimo
name: Pacini, Stefania
name: Branca, Jacopo J.V.
name: Ruggiero, Marco
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2013
Subjects: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; cadmium; transcranial sonography

description: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (CFS) is a neurological disease characterized by widespread inflammation and neuropathology. Aetiology and pathogenesis are unknown and it has been hypothesized that exposure to heavy metals is among the triggers of CFS. We recently hypothesized that cadmium, an occupational and environmental heavy metal pollutant, might be associated with some of the neurological findings typical of CFS. It is worth noticing that cadmium induces neuronal death in cortical neurons; cadmium-induced neuronal cell death and cadmium- induced low angiogenesis may be responsible for decrease in attention level and memory in exposed humans as well as to a diminished ability for training and learning in rats (symptoms patognomonic for CFS). In order to assess cadmiuminduced neuronal damage in vivo, we developed a modified procedure for transcranial sonography. This procedure allowed detailed visualization of the cortex of the temporal lobe, the meninges, the subarachnoidal space, and the meningeal and cortical vascularisation. The consequences of our observation could affect prevention, early diagnosis, and treatment of CFS with important repercussions in the definition of clinical cases and in forensic and insurance-related matters. CFS could then be considered as consequence of occupational or accidental exposure to cadmium. Implications in prevention and early diagnosis could entail the evaluation of symptoms typical of CFS in cadmium-exposed subjects as well as the search for signs of exposure to cadmium in subjects diagnosed with CFS. Also the management of the syndrome could be affected; nutritional supplementation of magnesium and zinc have been proposed in the prophylaxis and therapy of cadmium exposure.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012
The Structure of Cold Dark Matter Halos: Recent Insights from High Resolution Simulations
Creators: name: Zemp, Marcel
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We review results from recent high resolution cosmological structure formation simulations, namely the Via Lactea I & II and GHALO projects. These simulations study the formation of Milky Way sized objects within a cosmological framework. We discuss the general properties of cold dark matter halos at redshift z = 0 and focus on new insights into the structure of halos we got due to the unprecedented high resolution in these simulations.
description: 16 pages, 5 figures, invited brief review for MPLA
Additional file 1 of Trial Forge Guidance 3: randomised trials and how to recruit and retain individuals from ethnic minority groups—practical guidance to support better practice
Creators: name: Dawson, Shoba
name: Banister, Katie
name: Biggs, Katie
name: Cotton, Seonaidh
name: Devane, Declane
name: Gardner, Heidi
name: Gillies, Katie
name: Gopalakrishnan, Gosala
name: Isaacs, Talia
name: Khunti, Kamlesh
name: Nichol, Alistair
name: Parker, Adwoa
name: Russell, Amy M.
name: Shepherd, Victoria
name: Shiely, Frances
name: Shorter, Gillian
name: Starling, Bella
name: Williams, Hywel
name: Willis, Andrew
name: Witham, Miles D.
name: Treweek, Shaun
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Additional file 1.
Serous cutaneous glands substructural organization in anurans as a model of peptide/protein aggregation
Creators: name: Nosi, Daniele
name: Delfino, Giovanni
name: Quercioli, Franco
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2013
Subjects: Transmission electron microscopy; fourier transformation; secretory granules

description: A combined Transmission Electron Microscope (TEM) and Fourier Transformation (FT) analysis has been performed on the secretory granules storing active peptides/ proteins in cutaneous glands of n. 12 anuran species. Previous TEM investigation showed that the granules are provided with remarkable repeating substructures based on discrete subunits, arranged into a consistent framework. Furthermore, TEM analysis revealed that this recurrent arrangement is acquired during a prolonged post-Golgian (or maturational) processing that affects the secretory product. Maturation leads to a variety of patterns that depends on the degree of subunit clustering. Since the ultrastructural features of these biological samples were found to be suitable for FT analysis, this variety of recurrent patterns has been plotted into a range of FT frequency spectra. Through this quantitative approach we found that the variable granule substructure can be reduced to a main mechanism of peptides/proteins aggregation.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012
Hybrid Rules with Well-Founded Semantics
Creators: name: Drabent, W.
name: Maluszynski, J.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Logic in Computer Science (cs.LO)
subject: Artificial Intelligence (cs.AI)
subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences

description: A general framework is proposed for integration of rules and external first order theories. It is based on the well-founded semantics of normal logic programs and inspired by ideas of Constraint Logic Programming (CLP) and constructive negation for logic programs. Hybrid rules are normal clauses extended with constraints in the bodies; constraints are certain formulae in the language of the external theory. A hybrid program is a pair of a set of hybrid rules and an external theory. Instances of the framework are obtained by specifying the class of external theories, and the class of constraints. An example instance is integration of (non-disjunctive) Datalog with ontologies formalized as description logics. The paper defines a declarative semantics of hybrid programs and a goal-driven formal operational semantics. The latter can be seen as a generalization of SLS-resolution. It provides a basis for hybrid implementations combining Prolog with constraint solvers. Soundness of the operational semantics is proven. Sufficient conditions for decidability of the declarative semantics, and for completeness of the operational semantics are given.
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title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
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Year: 2018
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