cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Humanizing yeast sterol biosynthesis to understand evolution and disease
Creators: name: Curie, Sophie
Publisher: name: The University of Texas at Austin
Year: 2019
Subjects: yeast
CRISPR-Cas9
humanization

description: Baker’s yeast (​S. cerevisiae​) and humans (​H. sapiens​) have a relatively high level of genetic conservation in essential pathways including the proteasome, cytoskeleton, and sterol synthesis due to sharing a common ancestor approximately 1.1 billion years ago. This thesis focuses on the sterol biosynthesis pathway, which produces the related membrane lipids of ergosterol in yeast and cholesterol in humans, both of which are critical in maintaining cell membrane structure and fluidity. Yeast sterol biosynthesis genes are essential for yeast viability in standard lab growth conditions, however, previous studies in our laboratory have shown that yeast strains lacking genes for ergosterol biosynthesis can live if cholesterol is supplemented in the growth medium, suggesting these lipids may be interchangeable in yeast. To understand the extent to which yeast sterol biosynthesis can be humanized we systematically aimed to engineer this human pathway into yeast in place of its own genes. We took advantage of the CRISPR-Cas9 genetic engineering technique to systematically substitute yeast genes in the sterol pathway with their human equivalents. To date, we have humanized 80% of the yeast sterol biosynthesis pathway. Besides informing us about the evolution of core metabolic pathways across vast periods of divergence, a humanized yeast strain that contains the entire cholesterol biosynthesis pathway should serve as a remarkable new reagent for downstream medical research to help us better understand human lipid metabolic disease (including heart disease) and to perform high-throughput allelic variant and drug screens in this pathway.
NuSTAR Reveals Relativistic Reflection But No Ultra-Fast Outflow In The Quasar PG 1211+143
Creators: name: Zoghbi, A.
name: Miller, J. M.
name: Walton, D. J.
name: Harrison, F. A.
name: Fabian, A. C.
name: Reynolds, C. S.
name: Boggs, S. E.
name: Christensen, F. E.
name: Craig, W.
name: Hailey, C. J.
name: Stern, D.
name: Zhang, W. W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We report on four epochs of observations of the quasar PG 1211+143 using NuSTAR. The net exposure time is 300 ks. Prior work on this source found suggestive evidence of an 'ultra-fast outflow' (or, UFO) in the Fe K band, with a velocity of approximately 0.1c. The putative flow would carry away a high mass flux and kinetic power, with broad implications for feedback and black hole-galaxy co-evolution. NuSTAR detects PG 1211+143 out to 30 keV, meaning that the continuum is well-defined both through and above the Fe K band. A characteristic relativistic disk reflection spectrum is clearly revealed, via a broad Fe K emission line and Compton back-scattering curvature. The data offer only weak constraints on the spin of the black hole. A careful search for UFO's show no significant absorption feature above 90% confidence. The limits are particularly tight when relativistic reflection is included. We discuss the statistics and the implications of these results in terms of connections between accretion onto quasars, Seyferts, and stellar-mass black holes, and feedback into their host environments.
description: Accepted in ApJL
Alcoholism Treatment Issues Affecting African-American Youth
Creators: name: Loan, Ceola
Publisher: name: No Publisher Supplied
Year: 1989

description: A pamphlet from the Center of Alcohol Studies Pamphlet Series published 1986-1992 to provide "clear, concise information on a wide variety of topics important to the alcohol field. They are easily readable introductions by authors considered authorities in their area" [From original series description] .
When BLE Meets Light: Multi-modal Fusion for Enhanced Indoor Localization
Creators: name: Singh, Jagdeep
name: Farnham, Tim
name: Wang, Qing
Publisher: name: Zenodo
Year: 2023

description: Designing a reliable and highly accurate indoor localization system is challenging due to the non-uniformity of indoor spaces, multipath fading, and satellite signal blockage. To address these issues, we propose a Deep Neural Network-based localization system that combines passive Visible Light Positioning (p-VLP) and Bluetooth Low Energy (BLE) technologies to achieve stable, energy-efficient, and accurate indoor localization. Our solution leverages incremental learning to fuse data from visible light and BLE, overcoming their individual limitations and achieving centimeter-level localization accuracy. We build a prototype using low-cost S9706 hue sensors for p-VLP and low-power nrf52830 BLE boards to collect data simultaneously from both technologies in a 25m2 testbed. Our approach demonstrates a significant localization accuracy improvement of approximately 47% and 64% compared to individual p-VLP and BLE technologies, respectively, achieving a mean localization error of 20 cm
Employee Assistance Policies and Programs
Creators: name: Milgram, Gail G.
Publisher: name: No Publisher Supplied
Year: 1986

description: A pamphlet from the Center of Alcohol Studies Pamphlet Series published 1986-1992 to provide "clear, concise information on a wide variety of topics important to the alcohol field. They are easily readable introductions by authors considered authorities in their area" [From original series description] .
For the Tempus-fugitives: Christopher Norris on the Philosophy (and Poetry) of Colour
Creators: name: Barale, Alice
Publisher: name: Itinera
Year: 2020

description: Born in 1947, Christopher Norris is Emeritus Professor of Philosophy at Cardiff University. He worked first on literary criticism, then on the question of realism and antirealism in philosophy (as a strong adversary of antirealism), on Derrida and deconstructionism and, more recently, on the philosophy of science. In the past few years he has also authored several philosophical poems. In this issue we present two poems he wrote that are dedicated to color. Color is a recurrent theme in Norris’ poetry. Why? And why does Norris choose, for nearly ten years past, to mainly use poems for his philosophical investigations? Is there a link between his interest on color and this choice he has made? Moreover: Norris was always a strong adversary of antirealism and the extreme consequences of the “linguistic turn”. Isn’t there a contradiction between this philosophical position and the importance he gives to poetry? Perhaps color can give us a key.
description: Itinera, No 19 (2020): Colour for Philosophers
Lesbian Gay Bisexual Transgender Questioning/Queer Two-Spirit Adolescents and Suicidality
Creators: name: Tobin, Valerie
name: Sheth, Neeral K
name: Thompson, Hale M
name: Karnik, Niranjan S
Publisher: name: University of Illinois at Chicago
Year: 2023
Subjects: Uncategorized

description: Background: At a time when suicides are increasing throughout the United States, lesbian, gay, bisexual, transgender, and two spirit (LGBTQ2S) adolescents are at especially high risk for suicidal ideation, attempts, and completed suicide. Objectives: To 1) provide an overview and clinical perspective on LGBTQ2S suicidal ideation, attempts, and completed suicide; 2) discuss how the literature maps on to theories of suicide, and also points the way to clinical recommendations; and 3) give recommendations for clinical care based on this evidence. Method: This article uses a narrative review style to discuss the current concerns around LGBTQ2S adolescent suicide. The Social Ecological Model, the Interpersonal Psychological Theory of Suicide, and Minority Stress Theory are used describe the manner in which risks are acquired. Results: Emerging research demonstrates risks and protective factors in the lives of LGBTQ2S adolescents. The social context of LGBTQ2S adolescents puts them at risk for internalizing the experiences of discrimination evident in our society, In addition, there are other risk factors frequently associated with their LGBTQ2S status, such as substance misuse, homelessness, and lack of social support . Adolescents of color are especially vulnerable as they experience multiple marginalizations, often living in under resourced communities with poor access to health care. Support to families can be provided in the form of psychoeducation based on research findings. Social support is crucial and can be effectively provided in schools. Access to mental health care needs to be increased and barriers reduced. Conclusion: There is a need for more research, especially prospective study designs and research that centers adolescents of color and homeless adolescents. While there may be barriers to addressing the current rate of suicidality in this population, clinicians who work with adolescents can use a range of therapies to support their LGBTQ2S adolescent patients and their families, decreasing risk of suicidality.
Public-private perspectives on supply chains of essential goods in crisis management
Creators: name: Zienau, Alexander
Publisher: name: Karlsruher Institut für Technologie (KIT)
Year: 2023

description: Public authorities are responsible to maintain the population’s supply with essential goods like food or drugs at any time. Such goods are produced, transported and sold by companies in supply chains. Past supply crises all over the world have showcased numerous examples of spontaneous collaboration between public authorities and companies in supply chains. However, insights on formal collaboration which is agreed upon in the preparedness phase is rare in both practice and literature. Therefore, this dissertation’s first research objective is to identify under which circumstances companies are most willing to collaborate with public authorities. In this context, public authorities' and companies' characteristics, resources and roles in a collaboration are identified from literature research as well as real-life cases in Study A. Study B empirically determines companies' preferred preconditions for collaboration: Companies value the continuity of their business processes and expect to be compensated monetarily or by lifted restrictions. The second research objective is to develop collaborative supply chain concepts and evaluate them from public and private perspectives. Study C develops a collaboration concept in a real-time setting in which commercial trucks are jointly re-routed into crisis regions. In Study D, public authorities coordinate tactical use of commercial last-mile delivery vehicles for the home supply with food and drugs. In Study E, strategic collaboration in using dual-use warehouses is investigated with a focus on logistics networks. Study F determines the impact of demand shortfalls and payment term extensions on financial and physical flows in food supply chains. In Studies C-F, the main drivers for effectiveness and efficiency are investigated. By examining collaboration between companies and public authorities in supply crises, this dissertation contributes to the research streams of supply chain risk management and so-called extreme supply chain management. The results provide public decision-makers with insights into companies' motivation to engage in public crisis management. The developed collaborative supply chain concepts serve public authorities as a basis for collaboration design and companies as starting points for integrating public-private collaboration into their endeavors to make supply chains more resilient.
Two Poems on Colour
Creators: name: Norris, Christopher
Publisher: name: Itinera
Year: 2020

description: Christopher Norris is Emeritus Professor of Philosophy at Cardiff University. He worked on literary criticism, on the question of realism and antirealism in philosophy, on Derrida and deconstructionism and on the philosophy of science. In the past few years he has also authored several philosophical poems. In this issue we present two poems he wrote that are dedicated to color.
description: Itinera, No 19 (2020): Colour for Philosophers
What Shall We Teach The Young About Drinking?
Creators: name: Russell, Robert
Publisher: name: No Publisher Supplied
Year: 1986

description: A pamphlet from the Center of Alcohol Studies Pamphlet Series published 1986-1992 to provide "clear, concise information on a wide variety of topics important to the alcohol field. They are easily readable introductions by authors considered authorities in their area" [From original series description] .
Synesthesia: Where does Color Exist?
Creators: name: Cytowic, Richard
Publisher: name: Itinera
Year: 2020

description: Where does color exist? As a property of light in "red wavelengths," as a neural calculation by retinal photoreceptors, or as a calculation in the brain? The perceptual couplings of synesthesia, along with color constancy and colored shadows, suggest that color is not a property of objects: In order to be biologically useful within our environment of ever–changing illumination, the brain must assign stable colors to surfaces. Color exists only within the silent darkness of an individual skull. Richard E. Cytowic, MD MFA is Clinical Professor of Neurology at George Washington University, and the author most recently of “Synesthesia” and “Wednesday is Indigo Blue” (MIT Press).
description: Itinera, No 19 (2020): Colour for Philosophers
Line, Colour, Drawing in Kant and Hegel
Creators: name: Benjamin, Andrew
Publisher: name: Itinera
Year: 2020

description: Kant and Hegel have diametrically opposed views concerning the relationship between colour and drawing. For Hegel colour is all; while for Kant drawing is central. Through an analysis of both these positions the conclusion that is drawn is that colour and drawing have a necessary interrelation. One cannot be thought other than in relation to reach other. Taken together they are integral to the development of a philosophy of art.
description: Itinera, No 19 (2020): Colour for Philosophers
What Behavioral Scientists Know-and What They Can Do-about Alcoholism
Creators: name: Nathan, Peter
Publisher: name: No Publisher Supplied
Year: 1988

description: A pamphlet from the Center of Alcohol Studies Pamphlet Series published 1986-1992 to provide "clear, concise information on a wide variety of topics important to the alcohol field. They are easily readable introductions by authors considered authorities in their area" [From original series description] .
The steady pace of philosophy of colour
Creators: name: Brown, Derek
Publisher: name: Itinera
Year: 2020

description: I outline five issues in philosophy of colour that deserve greater attention and provide skeletal frameworks for how future work on these topics could be carried out. The issues are: colour and metaphilosophy (§1), colour and artistic practice (§2), colour and virtual/augmented reality (§3), colour and imagination (§4), and colour and the predictive mind (§5). Some of these issues have been a focus of important recent works. Thus, colour conjoined with each of metaphilosophy, artistic practice and imagination have all been examined in at least a few recent publications – see below for references. It is clear, however, that these recent works are signals that there is much still to be done. By contrast, while at present there is a great deal of interest in the predictive mind, the intersection of colour and the predictive mind is vastly underexplored. This is despite the fact that the philosophy and science of colour are rather developed disciplines. Finally, while there have been some very important recent works on virtual and augmented reality, the significance of colour for these studies has yet to be examined. It is my hope that after reading this article readers are convinced not only that the philosophy of colour has a rich, recent history, but also a very bright future.
description: Itinera, No 19 (2020): Colour for Philosophers
The Future of Engineering: Challenges and opportunities
Creators: name: Xochicale, Miguel
Publisher: name: Zenodo
Year: 2020

description: En esta plática se hablarán de los retos y oportunidades del futuro de la ingeniería. Se abordará la tendencia de la multidisciplinariedad de las ingenierías que están haciendo frente a diferentes retos actuales de la humanidad, como viajar a otros planetas, desenvolver los misterios del cerebro, comunicarse con más rapidez o la creación de equipo médico. Respecto a la multidisciplinariedad de las ingenierías, se partirá con el ejemplo de ingeniería robótica, que une varios frentes de la ingeniería: electrónica, mecánica, ciencias computacionales, mecatrónica, física o aún química. Además, se presentará como ejemplo de desarrollo los ventiladores de fuente abierta donde se unen ingenieros de varias disciplinas que llevan su trabajo colaborativo desde el diseño, prueba, y pasando por regulaciones médicas hasta llegar a su fabricación para uso en hospitales. Actualmente en ingeniería se presentan retos tanto individuales como grupales. Donde de esa idea de ser un genio solitario como Albert Einstein, Leonardo Da Vinci o Rick Sánchez es algo del pasado. Compartiré mi experiencia de trabajo en conjunto con un grupo de físicos, computólogos, ingenieros y clínicos que se unen con el fin de empujar las fronteras de la ingeniería biomedicina conjuntando inteligencia artificial, robótica y fotoacústica. Para finalizar la plática se expondrán algunos ejemplos de áreas emergentes de ingeniería como robótica médica, inteligencia artificial cuántica, biomateriales, etc., compartiendo algunas referencias y dejando el mensaje de la importancia de la colaboración y la constante fusión de áreas para seguir empujando los misterios de la naturaleza al beneficio de la humanidad.
Additional file 1 of Dynamic changes in quality of life in older patients with chronic obstructive pulmonary disease: a 7-year follow up
Creators: name: Yu, Chun-Hsiang
name: Tsai, Sheng-Han
name: Hung, Jo-Ying
name: Su, Pei-Fang
name: Hsu, Chih-Hui
name: Liao, Xin-Min
name: Hsiue, Tzuen-Ren
name: Chen, Chiung-Zuei
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1
Colour for Philosophers: Introduction
Creators: name: Barale, Alice
Publisher: name: Itinera
Year: 2020

description: «The ox becomes furious if a red cloth is shown to him, but the philosopher, who speaks of colour only in a general way, begins to rave». This is still true now: the philosophical discussion on colour is very lively. There is a debate within Anglo-American philosophy that has been going on for the past fifty years, and is still going on today, as is demonstrated by the imminent publication of the Routledge Handbook of Philosophy of Colour, which we are happy to announce in this issue. Colour is something very familiar but, nevertheless, it is also a subject on which philosophers never cease to raise questions. Why?
description: Itinera, No 19 (2020): Colour for Philosophers
«To call fools into a circle»: Benjamin’s interpretation of As you like it and The Tempest
Creators: name: Barale, Alice
Publisher: name: Itinera
Year: 2019

description: Calderon and Shakespeare are the two main authors that lie behind Benjamin’s examination of the German baroque drama. This paper addresses the importance of Shakespeare in his difference from the other big European cousin, Calderon. This does not mean that, according to Benjamin, Shakespeare is more important than Calderon (his beautiful essay on Calderon of 1923 contradicts this point), but rather that the English author brings to light an element that in Calderon is in some way missing. This is what Benjamin in some critical texts from the period of the Trauerpielbuch calls the «dramatic». Why does Benjamin say here that the dramatic precedes the tragic? And what does this have to do with the two Shakespearian characters he refers to in a letter of the same year, Caliban and Ariel? Moreover, is the interpretation of The Tempest that this passage implies the same as the one that he suggested in his previous essay on As you like it (1918)? These questions will lead to a few passages of the Trauerspielbuch that were particularly difficult to translate (not only in the two Italian previous translations, but also in the first English version, by John Osborne) and that can shed light on some important aspects of the book itself. In this context, another Shakespearian character will come to the aid, the Jacques of As you like it, with his Greek invocation «to call fools into a circle».
description: Itinera, No 18 (2019)
Induction of antioxidant and detoxifying systems of Chilo suppressalis Walker after exposure to entomopathogenic fungi
Creators: name: Shahriari, M
name: Zibaee, A
name: Dinan, MF
name: Armand, A
name: Tabari, M
name: Hoda, H
Publisher: name: Invertebrate Survival Journal
Year: 2023

description: The current study aimed to determine antioxidant and detoxifying responses of Chilo suppressalis Walker (Lepidoptera: Crambidae) to Beauveria bassiana (Strains BBRR1, BBAL1, BBLN1, BBLN2), Metarhizium anisopliae and Hirsutella subulata. The interactions of insect humoral immune responses with the entered conidia of entomopathogenic fungi in addition to nodule formation and melanization caused the production of several reactive oxygenate species (ROS), such as hydrogen peroxidase (H2O2), hydroperoxides (ROOH), superoxide radicals (O2−), and hydroxyl radical (OH−). The highest activity of catalase was recorded by BBRR1 and BBAL1, treatment after 48 to 96 h while the larvae treated by BBRR1 showed the highest peroxidase activity. Both ascorbate peroxidase and glucose-6-phosphate dehydrogenase showed the highest activity in the larvae treated by BBRR1 after 48-96 h. The highest concentration of Malondialdehyde reported in the larvae treated by BBRR1, BBAL1 and BBLN1, after 48 hours. The highest activity of general esterases was recorded in the larvae treated by BBRR1 after 48-96 hours. Similar results were recorded in the activity of glutathione-S-transferase but the enzyme had also the highest activity in the larvae treated by BBAL1 and BBLN2 after 48 hours. The larvae treated by BBRR1 and BBLN1 showed the highest activity of acid phosphatase after 72 and 96 hours while the highest activity of alkaline phosphatase was obtained in the larvae only treated by BBRR1 after 48-96 hours. The results clearly revealed that BBRR1 significantly and severely induced antioxidant and detoxifying systems of C. suppressalis larvae implying on virulence and immune induction of BBRR1 against the larvae.
description: Invertebrate Survival Journal, Vol 20 No 1 (2023)
Guidelines and best practices for game-based learning
Creators: name: Camilleri, Vanessa
Publisher: name: Zenodo
Year: 2023

description: The UPSKILLS project aims to enhance the development of transferable skills and knowledge in the language domain for modern linguists and language technology students. This document focuses on the use of games as a resource to support the acquisition of these skills and provides recommendations and guidelines for the successful implementation of game-based learning in higher education.
Alcohol Education Programming for Colleges and Universities
Creators: name: Spitzhoff Hill, Donna
Publisher: name: No Publisher Supplied
Year: 1991

description: A pamphlet from the Center of Alcohol Studies Pamphlet Series published 1986-1992 to provide "clear, concise information on a wide variety of topics important to the alcohol field. They are easily readable introductions by authors considered authorities in their area" [From original series description] .
All-optical coherent population trapping with defect spin ensembles in silicon carbide
Creators: name: Zwier, Olger V.
name: O'Shea, Danny
name: Onur, Alexander R.
name: van der Wal, Caspar H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Divacancy defects in silicon carbide have long-lived electronic spin states and sharp optical transitions, with properties that are similar to the nitrogen-vacancy defect in diamond. We report experiments on 4H-SiC that investigate all-optical addressing of spin states with the zero-phonon-line transitions. Our magneto-spectroscopy results identify the spin $S=1$ structure of the ground and excited state, and a role for decay via intersystem crossing. We use these results for demonstrating coherent population trapping of spin states with divacancy ensembles that have particular orientations in the SiC crystal.
description: 28 page document: Pages 1-14 main text (with 3 figures); pages 15-28 supplementary information (with 5 figues). v2 has minor corrections
A Novel Intelligent Management System Architecture for Hybrid VLC/RF Systems in Smart Retail Environment
Creators: name: Trung Ngo, Kien
name: Mangione, Stefano
name: Tinnirello, Ilenia
Publisher: name: Zenodo
Year: 2023

description: Novel IMS designed for smart retail environments. The proposed architecture integrates an intelligent handover controller, energy harvesting module, adaptive resource management, and edge tracking and localization. This architecture significantly improves smart retail operations by providing uninterrupted connectivity, targeted marketing, optimized store layouts, and enhanced user experiences.
Frequency-dependent polarizability of helium including relativistic effects with nuclear recoil terms
Creators: name: Piszczatowski, Konrad
name: Puchalski, Mariusz
name: Komasa, Jacek
name: Jeziorski, Bogumil
name: Szalewicz, Krzysztof
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Future metrology standards will be partly based on physical quantities computed from first principles rather than measured. In particular, a new pressure standard can be established if the dynamic polarizability of helium can be determined from theory with an uncertainty smaller than 0.2 ppm. We present calculations of the frequency-dependent part of this quantity including relativistic effects with full account of leading nuclear recoil terms and using highly optimized explicitly correlated basis sets. A particular emphasis is put on uncertainty estimates. At the He-Ne laser wavelength of 632.9908 nm, the computed polarizability value of 1.391 811 41 a.u. has uncertainty of 0.1 ppm that is two orders of magnitude smaller than those of the most accurate polarizability measurements. We also obtained an accurate expansion of the helium refractive index in powers of density.
description: Submitted to Phys. Rev. Lett
Temporal Intermittency of Energy Dissipation in Magnetohydrodynamic Turbulence
Creators: name: Zhdankin, Vladimir
name: Uzdensky, Dmitri A.
name: Boldyrev, Stanislav
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Plasma Physics (physics.plasm-ph)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Energy dissipation in magnetohydrodynamic (MHD) turbulence is known to be highly intermittent in space, being concentrated in sheet-like coherent structures. Much less is known about intermittency in time, another fundamental aspect of turbulence which has great importance for observations of solar flares and other space/astrophysical phenomena. In this Letter, we investigate the temporal intermittency of energy dissipation in numerical simulations of MHD turbulence. We consider four-dimensional spatiotemporal structures, "flare events", responsible for a large fraction of the energy dissipation. We find that although the flare events are often highly complex, they exhibit robust power-law distributions and scaling relations. We find that the probability distribution of dissipated energy has a power law index close to -1.75, similar to observations of solar flares, indicating that intense dissipative events dominate the heating of the system. We also discuss the temporal asymmetry of flare events as a signature of the turbulent cascade.
description: To appear in Physical Review Letters. 6 pages, 4 figures
Photometry and Blends: The Rubin Photo-z Challenges
Creators: name: Liang, Shuang
Publisher: name: Zenodo
Year: 2022
Subjects: Weak gravitational lensing

description: Weak Gravitational Lensing is a powerful probe for cosmology, and is one of the main goals for the Vera C. Rubin Observatory’s Legacy Survey of Space and Time (LSST). LSST will observe ∼ 1010 galaxies and measure their redshifts with broad-band photometry (photometric redshift; photo-z). This dissertation consists of three projects dedicated to improve LSST systematic uncertainties including photo-z measurements: 1. improve photometric calibration of u-band imaging; 2. identify overlapping galaxies (blends) with machine learning; 3. quantify the impact of blends in galaxy clusters on photo-z. Motivated by the photo-z challenges of Rubin-LSST, this work also has applications beyond photo-z or Rubin (e.g. cluster cosmology, galaxy shape measurements, Milky Way structure, or any optical observation with deep u-band imaging).
Double ramification cycles and quantum integrable systems
Creators: name: Buryak, A.
name: Rossi, P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Algebraic Geometry (math.AG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: In this paper we define a quantization of the Double Ramification Hierarchies of [Bur15b] and [BR14], using intersection numbers of the double ramification cycle, the full Chern class of the Hodge bundle and psi-classes with a given cohomological field theory. We provide effective recursion formulae which determine the full quantum hierarchy starting from just one Hamiltonian, the one associated with the first descendant of the unit of the cohomological field theory only. We study various examples which provide, in very explicit form, new $(1+1)$-dimensional integrable quantum field theories whose classical limits are well-known integrable hierarchies such as KdV, Intermediate Long Wave, Extended Toda, etc. Finally we prove polynomiality in the ramification multiplicities of the integral of any tautological class over the double ramification cycle.
description: Revised version, to be published in Letters in Mathematical Physics, 21 pages
Eye-tracking as a measure of social cognition for individuals with an intellectual disability
Creators: name: Jenner, Lauren
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: Developmental Psychology
subject: Cognitive Psychology
subject: Psychology
subject: FOS: Psychology
subject: eye-tracking
subject: genetic syndromes
subject: intellectual disability
subject: autism
subject: social cognition

description: This systematic review is pre-registered according to the NIRO guidelines (https://osf.io/f3brw/). The specific aims of the review are to: 1) characterise the ID groups (non-syndromic and syndromic) being tested across eye-tracking studies of social cognition, 2) describe the eye- tracking paradigms used, 3) report the main analyses and results and 4) identify whether differences in observable social behaviour are measured and analysed in relation to the eye- movement data. A detailed evaluation of the sample characteristics, eye-tracking methods and results will help advance knowledge on social-cognitive ability across non-syndromic and syndromic ID groups. Identifying possible relationships between eye-movements and observable social behaviour across these groups allows exploration of the profiles of social cognition underlying syndrome specific behavioural presentation. It may also provide a valuable method of evaluating whether observed social difficulties represent underlying social-cognitive deficits greater associated with co-occurring ASD than ID alone. Eye- tracking paradigms will be evaluated in terms of sample characteristics (i.e., degree of ID severity, non-verbal/verbal ability), to determine the accessibility of the measures used. Collating this information will support recommendations to improve inclusivity and better represent individuals with ID in social-cognitive research in the future.
RFI Environment at the OVRO LWA: Quantitative Measurements
Creators: name: D'Addario, L.
name: Hodges, Mark
Publisher: name: California Institute of Technology
Year: 2019

description: Measurements of the power spectral density of signals received by a few selected OVRO LWA antennas were collected for at least 24 hours over the frequency range 0 to 165 MHz. The objective was to quantify the RFI environment, concentrating primarily on the signals outside the target observing band of 25 to 85 MHz. Those out-of-band signals are subject to suppression by filtering. Significant filtering is practical only after the signals are delivered to the processing shelter, so these results can be used to set the dynamic range requirements for the RF-over-fiber links from outer antennas and for the pre-filtering analog signal processing at the shelter, as well as the amount of filtering needed to keep the signals within the dynamic range of the digitizers. It is found that the total power below 20 MHz (HF communication) is highly variable with peaks about 16 dB above the total power in the observing band, and that the total power above 88 MHz (primarily FM radio) is very stable at about 29 dB above the minimum power in the observing band. Sporadic in-band RFI is also seen.
description: LWA-OVRO Memo 2
Identification of large-scale cellular structures on the Sun based on the SDO and PSPT data
Creators: name: Efremov, V. I.
name: Parfinenko, L. D.
name: Solovev, A. A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Three independent sets of data: i). series of filtergrams obtained in line CaII K (393.416 nm) with the ground-based telescope Precision Solar Photometric Telescope (PSPT) of Mauna Loa Solar Observatory; ii). series of filtergrams of Atmospheric Imaging Assembly (AIA) of the Solar Dynamics Observatory (SDO) in λ160 nm and iii). series of magnetograms of Helioseismic and Magnetic Imager (HMI) of SDO have been processed to reveal reliably the existence of spatial cellular structures on the solar photosphere at scale about of 300 arcsec. This scale is intermediate between supergranules and giant cells (~30,000 and ~300,000 kilometers across, respectively). To identify the different spatial structures the tens of two-dimensional power spectra (2DFFT) have been averaged. For one-dimensional photometric cross sections of frames, the Fourier power spectra (FFT) and wavelet transforms (Morlet 5-th order) have been calculated.
description: 10 pages, 6 figures. Accepted in Astrophys Space Sci
Incidences between points and lines on a two-dimensional variety
Creators: name: Sharir, Micha
name: Solomon, Noam
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: We present a direct and fairly simple proof of the following incidence bound: Let $P$ be a set of $m$ points and $L$ a set of $n$ lines in ${\mathbb R}^d$, for $d\ge 3$, which lie in a common algebraic two-dimensional surface of degree $D$ that does not contain any 2-flat, so that no 2-flat contains more than $s \le D$ lines of $L$. Then the number of incidences between $P$ and $L$ is $$ I(P,L)=O\left(m^{1/2}n^{1/2}D^{1/2} + m^{2/3}\min\{n,D^{2}\}^{1/3}s^{1/3} + m + n\right). $$ When $d=3$, this improves the bound of Guth and Katz~\cite{GK2} for this special case, when $D$ is not too large. A supplementary feature of this work is a review, with detailed proofs, of several basic (and folklore) properties of ruled surfaces in three dimensions.
Human Activity and Soil Hostility
Creators: name: Choi, Jonathan
name: Dudek, Daniel
Publisher: name: QUBES Educational Resources
Year: 2023

description: The composition of soil can be broken down to a mixture of both abiotic and biotic matter. This composition can include animal waste, minerals, water, and even air. The complex nature of soil can consequently be affected by a large number of factors. These factors may range from simple weather alterations to complex human alterations to environments that could easily impose effects on soil. To see the effects humans can have on soil, this experiment was conducted in which three counties with varying levels of human activity (measured in population) had samples of soil collected to be tested for varying levels of pH and nutrients. Correlation tests were conducted to capture any significant correlation between the different levels of human activity and the variables tested in the soil. The results of these tests suggested that there was no significant correlation between varying degrees of human activity and soil pH and nutrient levels.
Microbial epibiotic community of the deep-sea galatheid squat lobster Munidopsis alvisca
Creators: name: Brinkhoff, T.
name: Milke, F.
name: Leinberger, J.
name: Caraveo-Patiño, J.
name: Teske, A.
name: Christodoulou, M.
name: Poehlein, A.
Publisher: name: Nature Research
Year: 2022

description: Life at hydrothermal vent sites is based on chemosynthetic primary producers that supply heterotrophic microorganisms with substrates and generate biomass for higher trophic levels. Often, chemoautotrophs associate with the hydrothermal vent megafauna. To investigate attached bacterial and archaeal communities on deep-sea squat lobsters, we collected ten specimens from a hydrothermal vent in the Guaymas Basin (Gulf of California). All animals were identified as Munidopsis alvisca via morphological and molecular classification, and intraspecific divergence was determined. Amplicon sequencing of microbial DNA and cDNA revealed significant differences between microbial communities on the carapaces of M. alvisca and those in ambient sea water. Major epibiotic bacterial taxa were chemoautotrophic Gammaproteobacteria, such as Thiotrichaceae and Methylococcaceae, while archaea were almost exclusively represented by sequences affiliated with Ca. Nitrosopumilus. In sea water samples, Marine Group II and III archaea and organoheterotrophic Alphaproteobacteria, Flavobacteriia and Planctomycetacia were more dominant. Based on the identified taxa, we assume that main metabolic processes, carried out by M. alvisca epibiota, include ammonia, methane and sulphide oxidation. Considering that M. alvisca could benefit from sulphide detoxification by its epibiota, and that attached microbes are supplied with a stable habitat in proximity to substrate-rich hydrothermal fluids, a mutualistic host-microbe relationship appears likely.
A communication toolkit for ARDC co-investment projects
Creators: name: ARDC
Publisher: name: Zenodo
Year: 2023
Subjects: communication toolkit, communication and marketing, communication for projects, communication plan template, communication strategy template, target audiences toolkit

description: This toolkit has been created to help you develop a communication strategy throughout your project lifecycle - from establishment to building and launch phases. Your communication strategy will help keep internal and external stakeholders well informed about the project, its long-term impact, and raise awareness and recognition amongst the wider community. Every project has varied levels of access to communication and marketing professionals within the project or at partner institutions. If you have communication resources, we recommend you talk to them, and use this toolkit to help you prepare for conversations about what communication support you need for your project. If you don’t have any resources, this can help you scope what you can achieve within your project to meet your communication objectives. This toolkit is designed to be a living document that you update regularly throughout your project, and use as a source of ideas and strategies to communicate your research data asset, tool or platform. How to use this toolkit: Read this toolkit through once to get ideas for what you need to do (expected time: 30 mins). Workshop sections of the toolkit with your team (two workshops ~50 mins each). Write and edit your communication plan (expected time: 1-2 hours). Toolkit outcomes: A communication strategy and plan for your project Target audiences identified Words to use when talking or writing about your project with your target audiences Communication tactics and channels for communicating with your target audiences Prior knowledge needed: you will need a good understanding of your project purpose and what it will achieve, and your target audience groups. For more information about the ARDC, visit ardc.edu.au.
Additional file 2 of Functional outcome of the anterior vaginal wall in a pelvic surgery injury rat model after treatment with stem cell-derived progenitors of smooth muscle cells
Creators: name: Wang, Yiting
name: Wen, Yan
name: Kim, Kayla
name: Wu, Hugo
name: Zhang, Jerry
name: Dobberfuhl, Amy D.
name: Chen, Bertha
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 2. Table S1. Contraction response of the middle portion of the vagina induced by carbachol and KCl. Data include mean value, standard deviation and confidence interval.
Dark Matter Directionality Revisited with a High Pressure Xenon Gas Detector
Creators: name: Mohlabeng, Gopolang
name: Kong, Kyoungchul
name: Li, Jin
name: Para, Adam
name: Yoo, Jonghee
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: An observation of the anisotropy of dark matter interactions in a direction-sensitive detector would provide decisive evidence for the discovery of galactic dark matter. Directional information would also provide a crucial input to understanding its distribution in the local Universe. Most of the existing directional dark matter detectors utilize particle tracking methods in a low-pressure gas time projection chamber. These low pressure detectors require excessively large volumes in order to be competitive in the search for physics beyond the current limit. In order to avoid these volume limitations, we consider a novel proposal, which exploits a columnar recombination effect in a high-pressure gas time projection chamber. The ratio of scintillation to ionization signals observed in the detector carries the angular information of the particle interactions. In this paper, we investigate the sensitivity of a future directional detector focused on the proposed high-pressure Xenon gas time projection chamber. We study the prospect of detecting an anisotropy in the dark matter velocity distribution. We find that tens of events are needed to exclude an isotropic distribution of dark matter interactions at 95% confidence level in the most optimistic case with head-to-tail information. However, one needs at least 10-20 times more events without head-to-tail information for light dark matter below 50 GeV. For an intermediate mass range, we find it challenging to observe an anisotropy of the dark matter distribution. Our results also show that the directional information significantly improves precision measurements of dark matter mass and the elastic scattering cross section for a heavy dark matter.
description: 19 pages, 10 figures, references added, v3. matches the version published in JHEP
A Zinpyr-1-based Fluorimetric Microassay for Free Zinc in Human Serum
Creators: name: Alker, Wiebke
name: Schwerdtle, Tanja
name: Schomburg, Lutz
name: Haase, Hajo
Publisher: name: Technische Universität Berlin
Year: 2019
Subjects: subject: 540 Chemie und zugeordnete Wissenschaften
subject: zinc
subject: free zinc
subject: serum
subject: biomarker
subject: fluorescent probe
subject: Zinypr-1

description: Zinc is an essential trace element, making it crucial to have a reliable biomarker for evaluating an individual’s zinc status. The total serum zinc concentration, which is presently the most commonly used biomarker, is not ideal for this purpose, but a superior alternative is still missing. The free zinc concentration, which describes the fraction of zinc that is only loosely bound and easily exchangeable, has been proposed for this purpose, as it reflects the highly bioavailable part of serum zinc. This report presents a fluorescence-based method for determining the free zinc concentration in human serum samples, using the fluorescent probe Zinpyr-1. The assay has been applied on 154 commercially obtained human serum samples. Measured free zinc concentrations ranged from 0.09 to 0.42 nM with a mean of 0.22 ± 0.05 nM. It did not correlate with age or the total serum concentrations of zinc, manganese, iron or selenium. A negative correlation between the concentration of free zinc and total copper has been seen for sera from females. In addition, the free zinc concentration in sera from females (0.21 ± 0.05 nM) was significantly lower than in males (0.23 ± 0.06 nM). The assay uses a sample volume of less than 10 µL, is rapid and cost-effective and allows us to address questions regarding factors influencing the free serum zinc concentration, its connection with the body’s zinc status, and its suitability as a future biomarker for an individual’s zinc status.
Longitudinal impact of interactive science activities: Developing, implementing, and validating a graphing integration inventory
Creators: name: Boda, Phillip
name: Bathia, Shruti
name: Linn, Marcia
Publisher: name: University of Illinois at Chicago
Year: 2023
Subjects: Uncategorized

description: Integrating sophisticated graphical analysis skills as they learn science is essential for K-12 students and emphasized in current standards. In this study, we iteratively designed a Graphing Integration Inventory (GII) over a three-year period, while also supporting students to develop their capabilities to use graphs to learn science content in complex ways through interactive curriculum materials implemented on a novel technology enhanced curriculum platform. We applied the Knowledge Integration framework to design the curriculum, the assessments, and the rubrics for scoring student explanations. The framework delineates ways to promote links among graphs and science ideas. The rubrics award students higher scores on their explanations based on the level of complexity of their connections between science concepts and, in this research, graphs. The GII and the aligned curriculum were implemented by over 300 middle school students (Grades 6–8) across a 3-year period. We investigated the impact of the designed curriculum on the integration of graphing and science while also studying the psychometric properties of the GII to validate it for use in future studies. Findings suggest both that the curriculum used to support these students improved their Knowledge Integration capabilities significantly and that the GII instrument is suitable for use with populations across gender and native English language status demographics in Grades 6–8. Implications are discussed around using graphs to learn complex science ideas, as well as the affordances of technology enhanced platforms to support this type of learning and assessment.