cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Risk of Colorectal Cancer for Carriers of Mutations in MUTYH, With and Without a Family History of Cancer
Creators: name: Boussioutas, Alex
name: Cleary, Sean P.
name: Jenkins, Mark A.
name: Haile, Robert W.
name: Buchanan, Daniel D.
name: Cotterchio, Michelle
name: Gallinger, Steven
name: Parry, Susan
name: Clendenning, Mark
name: Burnett, Terrilea
name: Hopper, John L.
name: Baron, John A.
name: Dowty, James G.
name: Giles, Graham G.
name: Tucker, Katherine M.
name: Rosty, Christophe
name: Le Marchand, Loïc
name: Win, Aung Ko
name: Macinnis, Robert J.
name: Goldblatt, Jack
name: Lindor, Noralane M.
name: Young, Joanne P.
name: Kim, Hyeja
name: Macrae, Finlay A.
name: Winship, Ingrid M.
name: Newcomb, Polly A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks, through 70 y of age, of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%–8.8%), irrespective of family history. For monoallelic MUTYH mutation carriers with a first-degree relative with CRC, diagnosed by 50 y of age who does not have the MUTYH mutation, risks of CRC were 12.5% for men and (95% CI, 8.6%–17.7%) and 10% for women (95% CI, 6.7%–14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population.
Dilaton black holes coupled to nonlinear electrodynamic field
Creators: name: Sheykhi, A.
name: Hajkhalili, S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The theory of nonlinear electrodynamics has got a lot of attentions in recent years. It was shown that Born-Infeld nonlinear electrodynamics is not the only modification of the linear Maxwell's field which keeps the electric field of a charged point particle finite at the origin, and other type of nonlinear Lagrangian such as exponential and logarithmic nonlinear electrodynamics can play the same role. In this paper, we generalize the study on the exponential nonlinear electrodynamics by adding a scalar dilaton field to the action. By suitably choosing the coupling of the matter field to the dilaton field, we vary the action and obtain the corresponding field equations. Then, by making a proper ansatz, we construct a new class of charged dilaton black hole solutions coupled to the exponential nonlinear electrodynamics field in the presence of two Liouville-type potentials for the dilaton field. Due to the presence of the dilaton field, the asymptotic behavior of these solutions are neither flat nor (A)dS. In the limiting case where the nonlinear parameter $β^2$ goes to infinity, our solution reduces to the Einstein-Maxwell dilaton black holes. We obtain the mass, temperature, entropy and electric potential of these solutions. We also study the behaviour of the electric field as well as the electric potential of these black holes near the origin. We find that the electric field has a finite value \textit{near} the origin, which is the same as the electric field of Born-Infeld nonlinear electrodynamics, but it can diverge exactly at $r=0$ depending on the model parameters. We also investigate the effects of the dilaton field on the behaviour of the electric field and electric potential. Finally, we check the validity of the first law of black hole thermodynamics on the black hole horizon.
description: 22 pages
Risk score to predict gastrointestinal bleeding after acute ischemic stroke
Creators: name: Wang, Yongjun
name: Pan, Yuesong
name: Li, Hao
name: Wang, Penglian
name: Wang, Yilong
name: Singhal, Aneesh B.
name: Liu, Gaifen
name: Ji, Ruijun
name: Shen, Haipeng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundGastrointestinal bleeding (GIB) is a common and often serious complication after stroke. Although several risk factors for post-stroke GIB have been identified, no reliable or validated scoring system is currently available to predict GIB after acute stroke in routine clinical practice or clinical trials. In the present study, we aimed to develop and validate a risk model (acute ischemic stroke associated gastrointestinal bleeding score, the AIS-GIB score) to predict in-hospital GIB after acute ischemic stroke.MethodsThe AIS-GIB score was developed from data in the China National Stroke Registry (CNSR). Eligible patients in the CNSR were randomly divided into derivation (60%) and internal validation (40%) cohorts. External validation was performed using data from the prospective Chinese Intracranial Atherosclerosis Study (CICAS). Independent predictors of in-hospital GIB were obtained using multivariable logistic regression in the derivation cohort, and β-coefficients were used to generate point scoring system for the AIS-GIB. The area under the receiver operating characteristic curve (AUROC) and the Hosmer-Lemeshow goodness-of-fit test were used to assess model discrimination and calibration, respectively.ResultsA total of 8,820, 5,882, and 2,938 patients were enrolled in the derivation, internal validation and external validation cohorts. The overall in-hospital GIB after AIS was 2.6%, 2.3%, and 1.5% in the derivation, internal, and external validation cohort, respectively. An 18-point AIS-GIB score was developed from the set of independent predictors of GIB including age, gender, history of hypertension, hepatic cirrhosis, peptic ulcer or previous GIB, pre-stroke dependence, admission National Institutes of Health stroke scale score, Glasgow Coma Scale score and stroke subtype (Oxfordshire). The AIS-GIB score showed good discrimination in the derivation (0.79; 95% CI, 0.764-0.825), internal (0.78; 95% CI, 0.74-0.82) and external (0.76; 95% CI, 0.71-0.82) validation cohorts. The AIS-GIB score was well calibrated in the derivation (P = 0.42), internal (P = 0.45) and external (P = 0.86) validation cohorts.ConclusionThe AIS-GIB score is a valid clinical grading scale to predict in-hospital GIB after AIS. Further studies on the effect of the AIS-GIB score on reducing GIB and improving outcome after AIS are warranted.
Association Between Molecular Subtypes of Colorectal Cancer and Patient Survival
Creators: name: Burnett-Hartman, Andrea N.
name: Newcomb, Polly A.
name: Weisenberger, Daniel J.
name: Phipps, Amanda I.
name: Buchanan, Daniel D.
name: Baron, John A.
name: Rosty, Christophe
name: Limburg, Paul J.
name: Potter, John D.
name: Sinicrope, Frank A.
name: Laird, Peter W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Colorectal cancer (CRC) is a heterogeneous disease that can develop via several pathways. Different CRC subtypes, identified based on tumor markers, have been proposed to reflect these pathways. We evaluated the significance of these previously proposed classifications to survival.
Preis- und Qualitätswettbewerb im Schweizer Gesundheitswesen - Rahmenbedingungen und Anreize
Creators: name: Willisegger, Jonas (Autor/in)
name: Blatter, Johannes (Autor/in)
Publisher: name: Zenodo
Year: 2016
Subjects: Gesundheitswesen
Schweiz
Tarife
Verhandlungen
Qualität

description: Keine Beschreibung.
description: + ID der Publikation: hslu_46661 + Art des Beitrages: Reihe + Reihe: Concordia Research, Nr. 1 + Sprache: Deutsch + Letzte Aktualisierung: 2017-04-12 09:58:13
Non-thermal Gravitino Production in Tribrid Inflation
Creators: name: Antusch, Stefan
name: Dutta, Koushik
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate non-thermal gravitino production after tribrid inflation in supergravity, which is a variant of supersymmetric hybrid inflation where three fields are involved in the inflationary model and where the inflaton field resides in the matter sector of the theory. In contrast to conventional supersymmetric hybrid inflation, where non-thermal gravitino production imposes severe constraints on the inflationary model, we find that the "non-thermal gravitino problem" is generically absent in models of tribrid inflation, mainly due to two effects: (i) With the inflaton in tribrid inflation (after inflation) being lighter than the waterfall field, the latter has a second decay channel with a much larger rate than for the decay into gravitinos. This reduces the branching ratio for the decay of the waterfall field into gravitinos. (ii) The inflaton generically decays later than the waterfall field, and does not produce gravitinos when it decays. This leads to a dilution of the gravitino population from the decays of the waterfall field. The combination of both effects generically leads to a strongly reduced gravitino production in tribrid inflation.
A study of instructional techniques used in the teaching of primary school students by means of interactive television: feedback, dialogue and interaction in a visual educational medium
Creators: name: Parr, Alan
Publisher: name: CQUniversity
Year: 2022
Subjects: subject: 130399 Specialist Studies in Education not elsewhere classified
subject: FOS: Educational sciences

description: The expansion of the teaching of Languages Other Than English to smaller primary schools in country areas of Queensland has been hampered by the lack of suitably qualified teachers. Efforts to teach these languages using distance education technologies such as the teleconference phone have resulted in limited success. The use of live interactive television has been mooted as one possible solution to this problem. This study investigates the nature and quality of teaching using one-way interactive television with two-way audio to two classes of Japanese in a small primary school in Central Queensland. It pays specific attention to the visual and interactive properties of the media used. The formative research methodology used is based on case study, ethnographic techniques relying on the collection of data through observation, videotape and interview. The analysis provides identification and detailed descriptions of instructional techniques within a theoretical framework encompassing learning theory, instructional design and distance teaching of Languages Other Than English. This study concludes with recommendations for action designed to build on the effective pedagogy identified here.
Burden of Gastrointestinal, Liver, and Pancreatic Diseases in the United States
Creators: name: Dellon, Evan S.
name: Gangarosa, Lisa M.
name: Pasricha, Sarina
name: Schmidt, Monica
name: Shaheen, Nicholas J.
name: Jensen, Elizabeth T.
name: Runge, Thomas
name: Lund, Jennifer L.
name: Eluri, Swathi
name: Sandler, Robert S.
name: Crockett, Seth D.
name: Peery, Anne F.
name: Barritt, Alfred S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Gastrointestinal (GI), liver, and pancreatic diseases are a source of substantial morbidity, mortality, and cost in the United States (US). Quantification and statistical analyses of the burden of these diseases are important for researchers, clinicians, policy makers, and public health professionals. We gathered data from national databases to estimate the burden and cost of GI and liver disease in the US.
The Jacobi-metric for timelike geodesics in static spacetimes
Creators: name: Gibbons, G. W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: It is shown that the free motion of massive particles moving in static spacetimes are given by the geodesics of an energy-dependent Riemannian metric on the spatial sections analogous to Jacobi's metric in classical dynamics. In the massless limit Jacobi's metric coincides with the energy independent Fermat or optical metric. For stationary metrics, it is known that the motion of massless particles is given by the geodesics of an energy independent Finslerian metric of Randers type. The motion of massive particles is governed by neither a Riemannian nor a Finslerian metric. The properies of the Jacobi metric for massive particles moving outside the horizon of a Schwarschild black hole are described. By constrast with the massless case, the Gaussian curvature of the equatorial sections is not always negative.
description: one reference added
Numerical evidence for universality in the excited instability spectrum of magnetically charged Reissner-Nordström black holes
Creators: name: Hod, Shahar
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: It is well-known that the SU(2) Reissner-Nordström black-hole solutions of the Einstein-Yang-Mills theory are characterized by an infinite set of unstable (imaginary) eigenvalues $\{ω_n(T_{\text{BH}})\}_{n=0}^{n=\infty}$ (here $T_{\text{BH}}$ is the black-hole temperature). In this paper we analyze the excited instability spectrum of these magnetically charged black holes. The numerical results suggest the existence of a universal behavior for these black-hole excited eigenvalues. In particular, we show that unstable eigenvalues in the regime $ω_n\ll T_{\text{BH}}$ are characterized, to a very good degree of accuracy, by the simple universal relation $ω_n(r_+-r_-)={\text{constant}}$, where $r_{\pm}$ are the horizon radii of the black hole.
description: 4 pages
Merging Solid-Phase Peptide Synthesis and Automated Glycan Assembly to Prepare Lipid-Peptide-Glycan Chimeras
Creators: name: Ricardo, Manuel G.
name: Seeberger, Peter H.
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: biomaterials
subject: glycan lipidation
subject: peptide amphiphiles
subject: peptide-glycan chimera
subject: self-assembling
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: Biomaterials with improved biological features can be obtained by conjugating glycans to nanostructured peptides. Creating peptide-glycan chimeras requires superb chemoselectivity. We expedite access to such chimeras by merging peptide and glycan solid-phase syntheses employing a bifunctional monosaccharide. The concept was explored in the context of the on-resin generation of a model α(1→6)tetramannoside linked to peptides, lipids, steroids, and adamantane. Chimeras containing a β(1→6)tetraglucoside and self-assembling peptides such as FF, FFKLVFF, and the amphiphile palmitoyl-VVVAAAKKK were prepared in a fully automated manner. The robust synthetic protocol requires a single purification step to obtain overall yields of about 20 %. The β(1→6)tetraglucoside FFKLVFF chimera produces micelles rather than nanofibers formed by the peptide alone as judged by microscopy and circular dichroism. The peptide amphiphile-glycan chimera forms a disperse fiber network, creating opportunities for new glycan-based nanomaterials.
Characterization of Genetic Loci That Affect Susceptibility to Inflammatory Bowel Diseases in African Americans
Creators: name: Patel, Ashish
name: Dhere, Tanvi A.
name: Kugathasan, Subra
name: Wang, Ming Hsi
name: Hanson, John S.
name: Duerr, Richard H.
name: Kirschner, Barbara S.
name: Kuemmerle, John F.
name: Katz, Jeffrey
name: Cutler, David J.
name: Liu, Zhenqiu
name: Kwon, John H.
name: Silverman, Ann
name: Scherl, Ellen J.
name: Alexander, Jonathan S.
name: Mannon, Peter
name: Chopra, Pankaj
name: Taylor, Kent D.
name: Dassopoulos, Themistocles
name: Simpson, Claire L.
name: Kappelman, Michael D.
name: Rich, Stephen S.
name: McGovern, Dermot P.B.
name: Hou, Jason K.
name: Okou, David T.
name: Di Rienzo, Anna
name: Baldassano, Robert N.
name: Haritunians, Talin
name: Rioux, John D.
name: Rotter, Jerome I.
name: Saeed, Shehzad
name: Silverberg, Mark S.
name: Datta, Lisa W.
name: Kao, Linda W.H.
name: Osuntokun, Bankole O.
name: Bridges, S. Louis
name: Cho, Judy H.
name: Kader, Howard
name: Zwick, Michael E.
name: Lazarev, Mark
name: Valentine, John F.
name: Kachelries, Kelly E.
name: Cross, Raymond K.
name: Ellis, Shannon
name: Moulton, Dedrick E.
name: Huang, Chengrui
name: Kimberly, Robert P.
name: Isaacs, Kim L.
name: Targan, Stephan R.
name: Hussain, Sunny Z.
name: Kumar, Archana
name: Kellermayer, Richard
name: Maranville, Joseph C.
name: Brant, Steven R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Inflammatory bowel disease (IBD) has familial aggregation in African Americans (AAs), but little is known about the molecular genetic susceptibility. Mapping studies using the Immunochip genotyping array expand the number of susceptibility loci for IBD in Caucasians to 163, but the contribution of the 163 loci and European admixture to IBD risk in AAs is unclear. We performed a genetic mapping study using the Immunochip to determine whether IBD susceptibility loci in Caucasians also affect risk in AAs and identify new associated loci.
Mechanistic mapping of (CS2/CO2)/epoxide copolymerization catalysis leads to terpolymers with improved degradability
Creators: name: Stephan, Jenny
name: Stühler, Merlin R.
name: Rupf, Susanne M.
name: Neale, Sam
name: Plajer, Alex J.
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: polymerization catalysis
subject: waste utilization
subject: degradable polymers
subject: heterobimetallic catalysis
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: The placement of main-group functionalities within polymers represents a strategy to access a wide catalog of materials but is limited by poor understanding of the catalyst selection criteria and polymerization mechanism when moving down the periodic table. Here, we study a series of new heterobimetallic carbon dioxide and carbon disulfide/epoxide copolymerization catalysts that allow for a comparative mechanistic understanding of two ring-opening copolymerization processes. We reveal that the distinct roles each metal plays are preserved from carbon dioxide to carbon disulfide, maintaining activity and selectivity across copolymerizations. Experimental and computational studies show that carbon disulfide/epoxide copolymerization can be understood as a series of structurally related insertion events that are interlinked by a central oxygen/sulfur scrambling reaction at the propagating chain end. This facilitates the synthesis of new carbon dioxide-/carbon disulfide-/epoxide-derived terpolymers with improved degradability over the parent carbon dioxide/epoxide copolymers at low levels of sulfur incorporation.
Automatic Facial Expression Recognition Using Features of Salient Facial Patches
Creators: name: Happy, S L
name: Routray, Aurobinda
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Extraction of discriminative features from salient facial patches plays a vital role in effective facial expression recognition. The accurate detection of facial landmarks improves the localization of the salient patches on face images. This paper proposes a novel framework for expression recognition by using appearance features of selected facial patches. A few prominent facial patches, depending on the position of facial landmarks, are extracted which are active during emotion elicitation. These active patches are further processed to obtain the salient patches which contain discriminative features for classification of each pair of expressions, thereby selecting different facial patches as salient for different pair of expression classes. One-against-one classification method is adopted using these features. In addition, an automated learning-free facial landmark detection technique has been proposed, which achieves similar performances as that of other state-of-art landmark detection methods, yet requires significantly less execution time. The proposed method is found to perform well consistently in different resolutions, hence, providing a solution for expression recognition in low resolution images. Experiments on CK+ and JAFFE facial expression databases show the effectiveness of the proposed system.
Chronic constipation in the elderly: a primer for the gastroenterologist
Creators: name: Chiarioni, Giuseppe
name: Ruggeri, Eugenio
name: Eusebi, Leonardo H.
name: Bazzoli, Franco
name: De Giorgio, Roberto
name: Stanghellini, Vincenzo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Constipation is a frequently reported bowel symptom in the elderly with considerable impact on quality of life and health expenses. Disease-related morbidity and even mortality have been reported in the affected frail elderly. Although constipation is not a physiologic consequence of normal aging, decreased mobility, medications, underlying diseases, and rectal sensory-motor dysfunction may all contribute to its increased prevalence in older adults. In the elderly there is usually more than one etiologic mechanism, requiring a multifactorial treatment approach. The majority of patients would respond to diet and lifestyle modifications reinforced by bowel training measures. In those not responding to conservative treatment, the approach needs to be tailored addressing all comorbid conditions. In the adult population, the management of constipation continues to evolve as well as the understanding of its complex etiology. However, the constipated elderly have been left behind while gastroenterology consultations for this common conditions are at a rise for the worldwide age increment. Aim of this review is to provide an update on epidemiology, quality of life burden, etiology, diagnosis, current approaches and limitations in the management of constipation in the older ones to ease the gastroenterologists’ clinic workload.
Decreasing Mortality Among Patients Hospitalized With Cirrhosis in the United States From 2002 Through 2010
Creators: name: Schmidt, Monica L.
name: Barritt, A. Sidney
name: Hayashi, Paul H.
name: Orman, Eric S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: It is not clear whether evidence-based recommendations for inpatient care of patients with cirrhosis are implemented widely or are effective in the community. We investigated changes in inpatient outcomes and associated features over time.
Diagnosis, Management, and Investigational Therapies for Food Allergies
Creators: name: Jones, Stacie M.
name: Burks, A. Wesley
name: Kulis, Mike
name: Wright, Benjamin L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Food allergies have increased in prevalence over the past 20 years, now becoming an important public health concern. Although there are no therapies currently available for routine clinical care, recent reports have indicated that immunotherapies targeting the mucosal immune system may be effective. Oral immunotherapy is conducted by administering small, increasing amounts of food allergen; it has shown promise for desensitizing individuals with peanut, egg, or milk allergies. Sublingual immunotherapy also desensitizes allergic patients to foods—2 major studies have examined the effects of sublingual immunotherapy in subjects with peanut allergies. We review the complex nature of IgE-mediated food allergies and the therapies being evaluated in clinical trials. We focus on the diagnosis and management of food allergies and investigational therapies.
Entanglement and Designs
Creators: name: Graydon, Matthew A.
name: Appleby, D. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We describe a connection between entanglement and designs. It involves the conical 2-designs introduced in a previous paper. These are a generalization of projective 2-designs which includes full sets of arbitrary rank mutually unbiased measurements (MUMs) and arbitrary rank symmetric informationally complete measurements (SIMs), as well as the more familiar MUBs and SICs. We show that a POVM is a conical 2-design if and only if there exists what we call a regular entanglement monotone whose restriction to the pure states is a function of the norm of the probability vector. In that case the concurrence is such a monotone. We also generalize and develop previous work on designs and entanglement detection.
description: 5 pages. v2: references updated
Effects of the Learning Curve on Efficacy of Radiofrequency Ablation for Barrett’s Esophagus
Creators: name: Ertan, Atilla
name: Muthusamy, V. Raman
name: Wolfsen, Herbert C.
name: Pruitt, Ron E.
name: Hathorn, Kelly E.
name: Shaheen, Nicholas J.
name: Chmielewski, Gary W.
name: Bulsiewicz, William J.
name: Pasricha, Sarina
name: Komanduri, Srinadh
name: Wolf, W. Asher
name: Li, Nan
name: Cotton, Cary
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Complete eradication of Barrett’s esophagus (BE) often requires multiple sessions of radiofrequency ablation (RFA). Little is known about the effects of case volume on the safety and efficacy of RFA, or the presence or contour of learning curves for this procedure.
Epidemiology, Diagnosis, and Management of Esophageal Adenocarcinoma
Creators: name: Rubenstein, Joel H.
name: Shaheen, Nicholas J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Esophageal adenocarcinoma (EAC) is rapidly increasing in incidence in Western cultures. Barrett’s esophagus (BE) is the presumed precursor lesion for this cancer. Several other risk factors for this cancer have been described, including chronic heartburn, tobacco use, Caucasian race, and obesity. Despite these known associations, most patients with EAC present with symptoms of dysphagia from late-stage tumors—only a small minority of patients are identified in screening and surveillance programs. Diagnostic analysis of EAC usually commences with upper endoscopy, followed by cross-sectional imaging. Endoscopic ultrasound is useful to assess local extent of disease as well as the involvement regional lymph nodes. T1a EAC may be treated endoscopically; some patients with T1b disease might also benefit from endoscopic therapy. Locally advanced disease is generally managed with esophagectomy, often accompanied by neoadjuvant chemoradiotherapy or chemotherapy. The prognosis is based on tumor stage: patients with T1a tumors have an excellent prognoses, whereas few patients with advanced disease have longterm survival.
Tau-REx II: Retrieval of emission spectra
Creators: name: Waldmann, Ingo P.
name: Rocchetto, Marco
name: Tinetti, Giovanna
name: Barton, Emma J.
name: Yurchenko, Sergey N.
name: Tennyson, Jonathan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Tau-REx (Tau Retrieval of Exoplanets) is a novel, fully Bayesian atmospheric retrieval code custom built for extrasolar atmospheres. In Waldmann et al. (2015) the transmission spectroscopic case was introduced, here we present the emission spectroscopy spectral retrieval for the Tau-REx framework. Compared to transmission spectroscopy, the emission case is often significantly more degenerate due to the need to retrieve the full atmospheric temperature-pressure (TP) profile. This is particularly true in the case of current measurements of exoplanetary atmospheres, which are either of low signal-to-noise, low spectral resolution or both. Here we present a new way of combining two existing approaches to the modelling of the said TP profile: 1) the parametric profile, where the atmospheric TP structure is analytically approximated by a few model parameters, 2) the Layer-by-Layer approach, where individual atmospheric layers are modelled. Both these approaches have distinct advantages and disadvantages in terms of convergence properties and potential model biases. The Tau-REx hybrid model presented here is a new two-stage TP profile retrieval, which combines the robustness of the analytic solution with the accuracy of the Layer-by-Layer approach. The retrieval process is demonstrated using simulations of the hot-Jupiter WASP-76b and the hot SuperEarth 55 Cnc e, as well as on the secondary eclipse measurements of HD189733b.
description: ApJ accepted
Discovery of kpc-scale line emission in barred galaxies, not linked to AGN or star formation
Creators: name: James, Phil A.
name: Percival, Susan M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present an analysis of the optical line emission from nearby barred galaxies, and in particular look at the radial range occupied by the bar. In many cases this region is marked by what we term a 'star formation desert', with a marked deficit of HII regions in optical narrow-band H-alpha imaging. Here we present long-slit spectroscopy revealing that such regions do have line emission, but that it is low-level, spatially smooth and almost ubiquitous. The relative strengths of the H-alpha and the spectrally adjacent [NII] lines in the regions are completely discrepant from those associated with star formation regions, and more closely match expectations for 'LINER' regions. We quantify the total line emission from these extended, kpc-scale regions, and determine the spurious contribution it would make to the determined star formation rate of these galaxies if interpreted as normal H-alpha emission. We concur with previous studies that link this LINER emission to old stellar populations, e.g. post-asymptotic giant branch stars, and propose these strongly-barred early-type spirals as a prime location for further tests of such emission.
description: Accepted for publication in MNRAS. 12 pages, 12 figures. Images reduced in resolution for arXiv version
Estimating the Trace of the Matrix Inverse by Interpolating from the Diagonal of an Approximate Inverse
Creators: name: Wu, Lingfei
name: Laeuchli, Jesse
name: Kalantzis, Vassilis
name: Stathopoulos, Andreas
name: Gallopoulos, Efstratios
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: Quantum Physics (quant-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: F.2.1

description: A number of applications require the computation of the trace of a matrix that is implicitly available through a function. A common example of a function is the inverse of a large, sparse matrix, which is the focus of this paper. When the evaluation of the function is expensive, the task is computationally challenging because the standard approach is based on a Monte Carlo method which converges slowly. We present a different approach that exploits the pattern correlation, if present, between the diagonal of the inverse of the matrix and the diagonal of some approximate inverse that can be computed inexpensively. We leverage various sampling and fitting techniques to fit the diagonal of the approximation to the diagonal of the inverse. Depending on the quality of the approximate inverse, our method may serve as a standalone kernel for providing a fast trace estimate with a small number of samples. Furthermore, the method can be used as a variance reduction method for Monte Carlo in some cases. This is decided dynamically by our algorithm. An extensive set of experiments with various technique combinations on several matrices from some real applications demonstrate the potential of our method.
description: 22 pages, 15 figures
No Ink on Ductal Carcinoma in Situ: A Single Centre Experience
Creators: name: FREGATTI, PIERO
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: Abstract Introduction: The incidence of ductal carcinoma in situ (DCIS) of the breast has greatly increased thanks to the widespread use of screening mammography. The primary aim of surgery is to prevent local recurrence by achieving a clear margin of resection although its extent still represents a controversial issue. Hence, a retrospective analysis of patients undergoing surgery for DCIS was performed in order to assess the association of margin widths of < 1 mm, 1 to 2 mm, and > 2 mm with ipsilateral breast tumor recurrence (IBTR) considering also the potential role of host-, tumor- and treatment-related factors. Methods: From 2000 to 2016, 388 patients diagnosed with pure DICS undergoing BCS with or without post-operative RT at the Breast Unit of ?Ospedale Policlinico San Martino? in Genoa were selected. The pathologic analysis was always performed according to a standardized protocol including the measure of the microscopic distance to the nearest radial margin: positive margins were those with DCIS present at the inked margin; close margins were considered to have tumor between 0.1 to 0.9 mm, or 1 to 1.9 mm, and negative margins were > 2 mm. Results: At a median follow-up of 90 months there were 26 IBTR (10 invasive and 16 DCIS). In univariate analysis there was a significant difference in IBTR by comparing positive versus close/negative margins of excision (P = 0.05) and the number of re-operations (P = 0.000). On multivariate analysis, both the margin status (P = 0.002) and the number of re-operations (P < 0.001) were still significantly associated with IBTR. The actuarial IBTR rates were significantly different in patients with a positive margin of excision at the primary operation as compared to patients with close/negative margins (log-rank test, P = 0,042) while the stratification by the margin width (0.1-0.9 mm; 1.0-1.9 mm; > 2 mm) was not significant (log-rank test, P = 0,243). Conclusions: The policy of ?no ink on the tumor? that is well accepted for invasive breast cancer can be translated to DCIS, because the actuarial IBTR rates were significantly different only in patients with a positive margin of excision as compared to patients with close/negative margins.
Valutazione dell?impatto sanitario ed economico dell?herpes zoster nei pazienti adulti ospedalizzati in Liguria: importanza della prevenzione vaccinale quale strumento per ridurre le complicanze, le patologie croniche e i costi della malattia
Creators: name: PIAZZA, MARIA FRANCESCA
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: The effect of severe Herpes Zoster (HZ) on chronic diseases is a component of the real burden of this vaccine-preventable disease that is not commonly considered. A retrospective cohort study was conducted to assess the health burden of severe HZ in adults ?50 years residing in Liguria Region from 2015 to 2017. Subjects hospitalized with and without HZ were matched (1:6 ratio). 437 subjects in the HZ cohort and 2622 subjects in the non-HZ cohort were enrolled. Previous immunodeficiency, autoimmune, and rare diseases are identified as main chronic conditions related to HZ hospitalization. Higher incidences of autoimmune (1.4% vs. 0.22%, p = 0.002) and gastrointestinal (7.04% vs. 3.62%, p = 0.015) diseases after hospitalization were observed in the HZ cohort compared to the non-HZ cohort. Significantly higher incidences were found after hospitalization versus the previous period for cardiovascular diseases (11.17% vs. 2.09%, p < 0.001), cerebral vasculopathy (6.13% vs. 0.60%, p < 0.001), non-arrhythmic myocardiopathy (4.31% vs. 0.59%, p = 0.002), and neuropathy (2.62% vs. 0.56%, p = 0.033). The HZ cohort showed a relative risk 10-fold higher for cerebral vasculopathy, 5-fold higher for cardiovascular diseases, and 7-fold higher for non-arrhythmic myocardiopathy. HZ causes a substantial impact on the chronic conditions. These data could suggest an implementation of HZ vaccination programs in the elderly and in high-risk groups.
Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study
Creators: name: Ragavan, Kowsalya
name: Chang, Charissa
name: Chalasani, Naga
name: Morlan, Wendy
name: Odin, Joseph
name: Dieterich, Douglas
name: Torrance, Rebecca J.
name: McClanahan-Crowder, Michelle
name: Dipaola, Frank
name: Marks, Kenari
name: Gu, Jiezhun
name: Chau, Tuan
name: Zacks, Steven
name: Schiano, Thomas
name: Reddy, K. Rajendar
name: Puglisi-Scharenbroich, Carmel
name: Kaplowitz, Neil
name: Darling, Jama
name: Bach, Nancy
name: Hammett, Alex
name: Lee, William
name: Navarro, Victor
name: Talwalkar, Jayant
name: McFadden, Regina
name: Milstein, Susan
name: Hayashi, Paul H.
name: Liangpunsakul, Suthat
name: Rostami, Hoss
name: Walker, Patricia
name: Mao, Sophana
name: Calvo, Francisco O.
name: Hooker, Judy
name: Fontana, Robert
name: Ghabril, Marwan S.
name: Galan, Katherine
name: Goldstein, David
name: Watkins, Paul B.
name: Corne, Audrey
name: Barnhart, Huiman X.
name: Russo, Mark
name: Van Raaphorst, Rebekah
name: Vuppalanchi, Raj
name: Stolz, Andrew
name: Fontana, Robert J.
name: Gopalreddy, Vani
name: Barnhart, Huiman
name: Serrano, Jose
name: Bonkovsky, Herbert L.
name: Beavers, Kimberly
name: De Boer, Ynto
name: Lichtman, Steven
name: Groseclose, Gale
name: Durazo, Francisco A.
name: Balasco, Amanda
name: Hoofnagle, Jay
name: Yalamanchili, Rachana
name: Verma, Manisha
name: Bansal, Meena
name: Kesar, Varun
name: Russell, Tracy
name: Conner, Gregory
name: Cummings, Sherrie
name: Peacock, Val
name: Ahmad, Jawad
name: Vega, Maricruz
name: Sherker, Averell H.
name: Everhart, James E.
name: Rossi, Simona
name: Chesney, Kristin
name: Rosado, Nidia
name: Mikhail, Sherif
name: Liu, Lawrence
name: Melgoza, Yolanda
name: Conjeevaram, Hari
name: Grewal, Priya
name: Navarro, Victor J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The drug-induced liver injury network (DILIN) is conducting a prospective study of patients with DILI in the United States. We present characteristics and subgroup analyses from the first 1257 patients enrolled in the study.
The gendered perceptions of physical education among tertiary students: An inquiry into student selection of physical education and outdoor recreation electives utilising a framework based upon an interpretation of Michel Foucault's History of Sexuality
Creators: name: Rose, Colin G.
Publisher: name: CQUniversity
Year: 2022
Subjects: subject: 130399 Specialist Studies in Education not elsewhere classified
subject: FOS: Educational sciences

description: One of the prevailing traditions in recent physical education theory has been the presentation of science based paradigms to inform physical education practice. Many other worldviews can be constructed, however, that can also contextualise what physical education is about. This study has focused upon the relationship of outdoor recreation and physical education in an attempt to demystify some of the implied assumptions of the debate. The notion that only knowledge of a scientific nature is worthy of a centralised position in physical education is a focus that this study specifically challenges. Through a review of literature it will be argued that outdoor recreation can offer much to empower physical education practice. The debate in literature is recounted in Chapter 3. The worldview that has informed this study, has been constructed around an investigaton of Michel Foucaults 'History of Sexuality'. This theoretical framework is supported in chapter 4 by the development of a methodological structure grounded in case study theory The development of this framework has been particularly useful in furthering an understanding of the influencing perceptions of both physical education and outdoor recreation university students. It has allowed the research project to peel back the layers that shroud perceptions of physical education and outdoor recreation. Student responses form the empirical study reported in chapter 5. The final chapter uses Foucauldian strategies to analyse the finding of this empirical study Suggestions for further research are also made in this concluding chapter.
Influence of viscosity contrast on buoyantly unstable miscible fluids in porous media
Creators: name: Pramanik, Satyajit
name: Hota, Tapan Kumar
name: Mishra, Manoranjan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences
subject: 76E15, 76E17, 76S99

description: The influence of viscosity contrast on buoyantly unstable miscible fluids in a porous medium is investigated through a linear stability analysis (LSA) as well as direct numerical simulations (DNS). The linear stability method implemented in this paper is based on an initial value approach, which helps to capture the onset of instability more accurately than the quasi-steady state analysis. In the absence of displacement, we show that viscosity contrast delays the onset of instability in buoyantly unstable miscible fluids. Further, it is observed that suitably choosing the viscosity contrast and injection velocity a gravitationally unstable miscible interface can be stabilized completely. Through LSA we draw a phase diagram, which shows three distinct stability regions in a parameter space spanned by the displacement velocity and the viscosity contrast. DNS are performed corresponding to parameters from each regime and the results obtained are in accordance with the linear stability results. Moreover, the conversion from a dimensionless formulation to the other and its essence to compare between two different type of flow problems associated with each dimensionless formulation are discussed.
description: 21 pages, 9 figures
Hepatitis C Virus Infection Induces Autocrine Interferon Signaling by Human Liver Endothelial Cells and Release of Exosomes, Which Inhibits Viral Replication
Creators: name: Stoddard, Mark
name: Mitchell, Angela
name: Shaw, George M.
name: Kriss, Michael
name: Gale, Michael
name: Edwards, Michael G.
name: Golden-Mason, Lucy
name: Shah, Vijay H.
name: Li, Hui
name: Stone, Amy E.L.
name: Rosen, Hugo R.
name: Giugliano, Silvia
name: Dobrinskikh, Evgenia
name: Yamane, Daisuke
name: Soto-Gutierrez, Alejandro
name: Khetani, Salman R.
name: Lemon, Stanley M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Liver sinusoidal endothelial cells (LSECs) make up a large proportion of the non-parenchymal cells in the liver. LSECs are involved in induction of immune tolerance, but little is known about their functions during hepatitis C virus (HCV) infection.
Electronic Supplementary Material from Collective navigation can facilitate passage through human-made barriers by homeward migrating Pacific salmon
Creators: name: Okasaki, Connie
name: Keefer, Matthew L.
name: Westley, Peter A. H.
name: Berdahl, Andrew M.
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Technical details of our statistical analysis
ACTION OBSERVATION COMBINED WITH CONVENTIONAL TRAINING IMPROVES THE RUGBY LINEOUT THROWING PERFORMANCE
Creators: name: FERRANDO, VITTORIA
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: Combining action observation (AO) and physical practice contributes to motor skill learning, and a number of studies pointed out the beneficial role of AO training in improving the motor performance and the athletes' movement kinematics. The aim of this study was to investigate if AO combined with immediate conventional training was able to improve motor performance and kinematic parameters of a complex motor skill such as the lineout throw, a gesture that represents a key aspect of rugby, that is unique to this sport. Twenty elite rugby players were divided into two groups. The AO group watched a 5-min video-clip of an expert model performing the lineout throw toward a target at 7 m distance and, immediately after the AO, this group executed the conventional training, consisting of six repetitions x five blocks of throws. The CONTROL group performed only the conventional lineout training. Intervention period lasted 4 weeks, 3 sessions/week. The AO group showed significant improvements in throwing accuracy (i.e., number of throws hitting the target), whilst no significant changes were observed in the CONTROL group. As concerns kinematic parameters, hooker's arm mean velocity significantly increased in both groups, but the increase was higher in AO group compared to CONTROL group. Ball velocity significantly increased only in the AO group, whereas ball angle release and ball spinning significantly decreased in both groups, with no differences between groups. Finally, no significant changes in knee and elbow angles were observed. Our results showed that the combination of AO and conventional training was more effective than a conventional training alone in improving the performance of elite rugby players, in executing a complex motor skill, such as the lineout. This combined training led to significant improvements in throwing accuracy and in hooker's and ball's kinematic parameters. Since AO can be easily implemented in combination with conventional training, the results of this study can encourage coaches in designing specific lineout training programs, which include AO cognitive training.
Incidence of Esophageal Adenocarcinoma and Causes of Mortality After Radiofrequency Ablation of Barrett’s Esophagus
Creators: name: Chmielewski, Gary W.
name: Infantolino, Anthony
name: Shaheen, Nicholas J.
name: Pruitt, Ron E.
name: Muthusamy, V. Raman
name: Chang, Kenneth J.
name: Lightdale, Charles J.
name: Camara, Daniel S.
name: Pasricha, Sarina
name: Wolfsen, Herbert
name: Komanduri, Srinadh
name: Li, Nan
name: Rothstein, Richard I.
name: Wolf, W. Asher
name: Ertan, Atilla
name: Cotton, Cary
name: Overholt, Bergein F.
name: Corbett, F. Scott
name: Triadafilopoulos, George
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Radiofrequency ablation (RFA) is commonly used to treat Barrett's esophagus (BE). We assessed the incidence of esophageal adenocarcinoma (EAC) after RFA, predictors of EAC, and EAC-specific and all-cause mortality rates.
Simulation and Design of Microwave Heating Oven for Interaction Study of Microwave and Oil Palm Fruits
Creators: name: Mudtorlep Nisoa
Publisher: name: Research Administration Division
Year: 2022
Subjects: Microwave
Free fatty acid
DOBI
COMSOL Multiphysics
Crude palm oil (CPO)

description: Thai Science and Technology Journal, 30, 4, 15-31