cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Optical detection of strain and doping inhomogenieties in single layer MoS2
Creators: name: Michail, Antonios
name: Delikoukos, Nick
name: Parthenios, John
name: Galiotis, Costas
name: Papagelis, Konstantinos
Publisher: name: arXiv
Year: 2018
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Van der Waals single-layer materials are characterized by an inherent extremely low bending rigidity and therefore are prone to nanoscale structural modifications due to substrate interactions. Such interactions can induce excess charge concentration, conformational ripples and residual mechanical strain. In this work, we employed spatially resolved Raman and Photoluminescence images to investigate strain and doping inhomogeneities in a single layer exfoliated Molybdenum disulphide crystal. We have found that correlations between the spectral parameters of the most prominent Raman bands A1' and E' enable us to decouple and quantify strain and charge doping effects. In comparison with AFM topography, we show that the spatial distribution of the linewidth of the A-exciton peak is strain sensitive and can capture features smaller than the laser spot size. The presented optical analysis may have implications in the development of high-quality devices based on two-dimensional materials since structural and electronic modifications affect considerably their carrier mobility and conductivity.
description: 12 pages, 3 figures
title: ADCO, Cartulaire de Cîteaux pour la grange et seigneurie d'Ouges (XVe siècle), Cart. 173 (11 H 939), 226 folios, f. 0265
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Cartulaire de Cîteaux pour la grange et seigneurie d'Ouges (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 173 (11 H 939), 226 folios, f. 0265, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour la grange et seigneurie d'Ouges (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 173 (11 H 939), 226 folios, f. 0265, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Coupled IEEE 802.11ac and TCP Goodput improvement using Aggregation and Reverse Direction
Creators: name: Sharon, Oran
name: Alpert, Yaron
Publisher: name: arXiv
Year: 2018
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: This paper suggests a new model for the transmission of TCP traffic over IEEE 802.11 using the new features of IEEE 802.11ac . The paper examines a first step in this direction and as such we first consider a single TCP connection, which is typical in a home environment. We show that when the IEEE 802.11ac MAC is aware of QoS TCP traffic, using Reverse Direction improves the TCP Goodput in tens of percentages compared to the traditional contention based channel access. In an error-free channel this improvement is 20% while in an error-prone channel the improvement reaches 60%, also using blind retransmission of frames. In our operation modes we also assume the use in Two-Level aggregation scheme, the ARQ protocol of the IEEE 802.11ac MAC layer and also assume the data rates and the four Access Categories defined in this standard.
description: 41 pages, 15 figures
Additional file 1: of Impact of alcohol disorder and the use of illicit drugs on tuberculosis treatment outcomes: a retrospective cohort study
Creators: name: Pelissari, Daniele
name: Diaz-Quijano, Fredi
Publisher: name: figshare
Year: 2018
Subjects: Medicine
Pharmacology
Biotechnology
Science Policy

description: Table S1. Profile study population with and without tuberculosis treatment outcome registration, São Paulo-state, Brazil, 2011–2015 (n = 79,075). (DOCX 23 kb)
Announcement of the Summer Session Supplement to Calendar 1950-51 Thirty-second Session: July 3rd to August 17th, 1951
Creators: name: University Of British Columbia
Publisher: name: Vancouver : University of British Columbia
Year: 2017

description: Announcement of courses for the 32nd summer session at the University of British Columbia, taking place from July 3rd to August 17th, 1951. Contains course schedule, course descriptions and details, fees, and other information about the session.
Theoretical implications of the galactic radial acceleration relation of McGaugh, Lelli, and Schombert
Creators: name: Nesbet, R. K.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Velocities in stable circular orbits about galaxies, a measure of centripetal gravitation, exceed the expected Kepler/Newton velocity as orbital radius increases. Standard LCDM attributes this anomaly to galactic dark matter. McGaugh et al have recently shown for 153 disc galaxies that observed radial acceleration is an apparently universal function of classical acceleration computed for observed galactic baryonic mass density. This is consistent with the empirical MOND model, not requiring dark matter. It is shown here that suitably constrained LCDM and conformal gravity (CG) also produce such a universal correlation function. LCDM requires a very specific dark matter distribution, while the implied CG nonclassical acceleration must be independent of galactic mass. All three constrained radial acceleration functions agree with the empirical baryonic $v^4$ Tully-Fisher relation. Accurate rotation data in the nominally flat velocity range could distinguish between MOND, LCDM, and conformal gravity.
description: 5 pages accepted by MNRAS 02/27/2018
The physical hamiltonian in nonperturbative quantum gravity
Creators: name: Rovelli, Carlo
name: Smolin, Lee
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A quantum hamiltonian which evolves the gravitational field according to time as measured by constant surfaces of a scalar field is defined through a regularization procedure based on the loop representation, and is shown to be finite and diffeomorphism invariant. The problem of constructing this hamiltonian is reduced to a combinatorial and algebraic problem which involves the rearrangements of lines through the vertices of arbitrary graphs. This procedure also provides a construction of the hamiltonian constraint as a finite operator on the space of diffeomorphism invariant states as well as a construction of the operator corresponding to the spatial volume of the universe.
description: Latex, 11 pages, no figures, CGPG/93/2
Announcement of the Summer Session Supplement to Calendar 1951-1952 Thirty-third Session: July 2nd to August 19th, 1952
Creators: name: University Of British Columbia
Publisher: name: Vancouver : University of British Columbia
Year: 2017

description: Announcement of courses for the 33rd summer session at the University of British Columbia, taking place from July 2nd to August 19th, 1952. Contains course schedule, course descriptions and details, fees, and other information about the session.
Additional file 5: of Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control
Creators: name: MartĂ­Nez-Lumbreras, Santiago
name: Krysztofinska, Ewelina
name: Thapaliya, Arjun
name: Spilotros, Alessandro
name: Matak-Vinkovic, Dijana
name: Salvadori, Enrico
name: Roboti, Peristera
name: Nyathi, Yvonne
name: Muench, Janina
name: Roessler, Maxie
name: Svergun, Dmitri
name: High, Stephen
name: Isaacson, Rivka
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology

description: Figure S5. Complete analysis of the chemical shift difference between SGTA constructs for the same backbone amide signal in 1H-15N HSQC spectra. N-terminal, TPR, C-terminal, and other comparisons appear in consecutive pages. (PDF 3505 kb)
Announcement of the Summer Session Supplement to Calendar 1952-1953 Thirty-fourth Session: July 6th to August 21st, 1953
Creators: name: University Of British Columbia
Publisher: name: Vancouver : University of British Columbia
Year: 2017

description: Announcement of courses for the 34th summer session at the University of British Columbia, taking place from July 6th to August 21st, 1953. Contains course schedule, course descriptions and details, fees, and other information about the session.
Orbits of real forms in complex flag manifolds
Creators: name: Altomani, Andrea
name: Medori, Costantino
name: Nacinovich, Mauro
Publisher: name: arXiv
Year: 2007
Subjects: subject: Complex Variables (math.CV)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53C30 (Primary), 14M15, 17B20, 32V05, 32V35, 32V40, 57T20 (Secondary)

description: We investigate the $CR$ geometry of the orbits $M$ of a real form $G_0$ of a complex simple group $G$ in a complex flag manifold $X=G/Q$. We are mainly concerned with finite type, Levi non-degeneracy conditions, canonical $G_0$-equivariant and Mostow fibrations, and topological properties of the orbits.
description: 36 pages To appear on Annali della Scuola Normale Superiore di Pisa v2: major revision v3: version accepted for publication
Extrinsic and intrinsic regulation of breast cancer progression - promoting an aggressive phenotype via alterations in cellular populations and subcellular compartments
Creators: name: Donatello, Simona
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Breast cancer is one of the most common worldwide cancers. Most breast cancer deaths are caused when tumour cells disseminate from the primary tumour to form metastases in other organs. Many intrinsic and extrinsic mechanisms are involved in progression to a metastatic phenotype. Thus, the aim of this thesis was to study from complementary perspectives key mechanisms involved in altering cellular homeostasis that could promote tumour progression. The first aim was to establish primary culture models from human breast tumour and non-tumour tissues, and to validate functional differences between the models that could underpin tumour progression. Tumour cultures were found to senesce significantly less than nontumour cultures. More importantly, calculation of a novel proliferation : senescence ratio revealed that a stepwise increase in this ratio correlated with a tumour progression paradigm, from non-tumour through low grade tumours and finally high grade tumours. Since there were signs that primary cultures were enriched in progenitor/stem cells, the second aim was to determine whether an imbalance in progenitor populations could associate with clinicopathological parameters of cancer progression. Putative progenitor populations were identified by flow cytometry as either double negative (DN) or double positive (DP) for the epithelial marker EPCAM and the myoepithelial marker CALLA. An increased DN : DP ratio was observed to positively correlate with poor prognosis tumours, namely those of high grade, ER-negativity or HER2 positivity. Therefore these results suggest for the first time that not only the presence of single progenitor populations but also maintenance of a correct balance between them could affect tissue homeostasis and contribute to tumour progression. However, altered self-renewal ability is not the only driver for tumour progression, but also altered migratory properties of tumour cells via proteins such as the lipid raft-affiliated protein CD44. Thus the third aim of this thesis was to dissect the role of lipid rafts in regulating CD44-mediated cell migration. In the metastatic cell line MDA-MB-231, CD44 was found to interact with its migratory binding partner ezrin only outside lipid rafts; that forced retention of CD44 in rafts abolished these interactions and concomitantly reduced cell migration. These results suggest a novel role for lipid rafts in sequestering CD44 to regulate its participation in breast cancer cell migration. Taken together, results presented in this thesis suggest that many complementary cellular events promote breast tumour progression. Some of the novel mechanisms uncovered may represent future targets for developing more powerful treatments against breast cancer.
Additional file 3 of Association of dyslipidemia with the severity and mortality of coronavirus disease 2019 (COVID-19): a meta-analysis
Creators: name: Liu, Yanli
name: Pan, Yilong
name: Yin, Yuyao
name: Chen, Wenhao
name: Li, Xiaodong
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 3: Figure S1: Sensitivity analysis demonstrating the association of dyslipidemia with COVID-19 mortality.
Additional file 1: of Whole-transcriptome changes in gene expression accompany aging of sensory neurons in Aplysia californica
Creators: name: Greer, Justin
name: Schmale, Michael
name: Fieber, Lynne
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified

description: Table S1. Primer sequences and amplicon lengths for qPCR. Table S2. Read depth and mapping statistics using fastxtoolkit and STAR. Table S3. List of canonical pathways identified in IPA. Figure S1. Representative quality score boxplot for reads after quality filtering. Figure S2. Visualization of regulatory network involving ion channel genes from IPA. (DOCX 5196 kb)
Dayside magnetospheric and ionospheric responses to a foreshock transient on June 25, 2008: 2. 2-D evolution based on dayside auroral imaging
Creators: name: Wang, Boyi
name: Nishimura, Yukitoshi
name: Hietala, Heli
name: Shen, Xiao-Chen
name: Shi, Quanqi
name: Zhang, Hui
name: Lyons, Larry
name: Zou, Ying
name: Angelopoulos, Vassilis
name: Ebihara, Yusuke
name: Weatherwax, Allan
Publisher: name: arXiv
Year: 2018
Subjects: subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: The foreshock region involves localized and transient structures such as foreshock cavities and hot flow anomalies due to solar wind-bow shock interactions, and foreshock transients have been shown to lead to magnetospheric and ionospheric responses. In this paper, the interaction between a foreshock transient and the magnetosphere-ionosphere system is investigated using dayside aurora imagers revealing structures and propagation in greater detail than previously possible. A foreshock transient was detected by THEMIS-B and C during 1535-1545 UT on June 25, 2008. THEMIS-A, D and E observed magnetopause compression, cold plasma enhancement and ULF waves in the dayside magnetosphere. The all-sky imager (ASI) at South Pole observed that both diffuse and discrete aurora brightened locally soon after the appearance of this foreshock transient. The diffuse aurora brightening, which corresponded to a region a few Re size in GSM-Y in the equatorial plane, propagated duskward with an average speed of ~100 km/s. Soon after the diffuse aurora brightened, discrete aurora also brightened and extended duskward, which was consistent with the motion of the foreshock transient as it swept through the magnetosheath while impacting the magnetopause. Equivalent horizontal currents measured by magnetometers revealed a pair of field-aligned currents (FACs) moving duskward consistent with motion of the discrete aurora patterns. We conclude that the high-resolution and two-dimensional observation of auroral responses by ground-based ASI can help to estimate the evolution and propagation of upstream foreshock transients and their substantial impacts on the magnetosphere-ionosphere coupling system, including magnetospheric compression and currents in the ionosphere.
Using Chemistry to Unveil the Kinematics of Starless Cores: Complex Radial Motions in Barnard 68
Creators: name: Maret, Sébastien
name: Bergin, Edwin A.
name: Lada, Charles J.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present observations of 13CO, C18O, HCO+, H13CO+, DCO+ and N2H+ line emission towards the Barnard 68 starless core. The line profiles are interpreted using a chemical network coupled with a radiative transfer code in order to reconstruct the radial velocity profile of the core. Our observations and modeling indicate the presence of complex radial motions, with the inward motions in the outer layers of the core but outward motions in the inner part, suggesting radial oscillations. The presence of such oscillation would imply that B68 is relatively old, typically one order of magnitude older than the age inferred from its chemical evolution and statistical core lifetimes. Our study demonstrates that chemistry can be used as a tool to constrain the radial velocity profiles of starless cores.
description: 12 pages, 3 figures, to appear in the Astrophysical Journal Letters
Announcement of the Summer Session Supplement to Calendar 1953-1954 Thirty-fifth Session: July 5th to August 20th, 1954
Creators: name: University Of British Columbia
Publisher: name: Vancouver : University of British Columbia
Year: 2017

description: Announcement of courses for the 35th summer session at the University of British Columbia, taking place from July 5th to August 20th, 1954. Contains course schedule, course descriptions and details, fees, and other information about the session.
Noise Correlation in Cosmic Microwave Background Experiments
Creators: name: Dodelson, Scott
name: Kosowsky, Arthur
name: Myers, Steven T.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Many analyses of microwave background experiments neglect the correlation of noise in different frequency or polarization channels. We show that these correlations, should they be present, can lead to severe misinterpretation of an experiment. In particular, correlated noise arising from either electronics or atmosphere may mimic a cosmic signal. We quantify how the likelihood function for a given experiment varies with noise correlation, using both simple analytic models and actual data. For a typical microwave background anisotropy experiment, noise correlations at the level of 1\% of the overall noise can seriously {\it reduce} the significance of a given detection.
description: Analysis generalized; conclusions unaltered
Angular Diameters as a Probe of a Cosmological Constant and $Ω$
Creators: name: Krauss, Lawrence M.
name: Schramm, David
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The lensing effect of curved space, which can cause the angular diameter of a fixed reference length seen on the sky to reach a minimum and then increase with redshift, depends sensitively on the value of the cosmological constant, $Λ$, in a flat universe. The redshift of an observed minimum and the asymptotic slope can in principle provide strong constraints on $Λ$. The sensitivity to a non-zero cosmological constant in a flat universe is compared to the sensitivity to $q_0$ in an open universe without a cosmological constant, and to inherent ambiguities due to uncertainties in distance measures and the possible effects of evolution. If evolutionary uncertainties can be overcome, the reported observations of the angular diameter of compact radio jets as a function of redshift, which appear to exhibit such a minimum, could provide the strongest available limit on the cosmological constant in a flat universe, and on $Ω$ in an open universe.
description: 10 pages plus 4 figures (not included)
A new method to compute limb-darkening coefficients for stellar atmosphere models with spherical symmetry: the space missions TESS, Kepler, Corot, and MOST
Creators: name: Claret, Antonio
Publisher: name: arXiv
Year: 2018
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: One of the biggest problems we can encounter while dealing with the limb-darkening coefficients for stellar atmospheric models with spherical symmetry is the difficulty of adjusting both the limb and the central parts simultaneously. In particular, the regions near the drop-offs are not well reproduced for most models, depending on Teff, log g, or wavelength. Even if the law with four terms is used, these disagreements still persist. Here we introduce a new method that considerably improves the description of both the limb and the central parts and that will allow users to test models of stellar atmospheres with spherical symmetry more accurately in environments such as exoplanetary transits, eclipsing binaries, etc. The method introduced here is simple. Instead of considering all the $μ$ points in the adjustment, as is traditional, we consider only the points until the drop-off ($μ_{cri}$) of each model. From this point, we impose a condition ${I(μ)}/{I (1)} = 0$. All calculations were performed by adopting the least-squares method. The resulting coefficients using this new method reproduce the intensity distribution of the PHOENIX spherical models (COND and DRIFT) quite well for the photometric systems of the space missions {\sc TESS}, {\sc KEPLER}, {\sc COROT}, and {\sc MOST}. The calculations cover the following ranges of local gravity and effective temperatures: 2.5 $\leq$ log g $\leq$ 6.0 and 1500 K $\leq$ T$_{\rm eff}$ $\leq$ 12000 K. The new spherical coefficients can easily be adapted to the most commonly used light curve synthesis codes.
Announcement of the Summer Session Supplement to Calendar 1954-1955 Thirty-sixth Session: July 4th to August 19th, 1955
Creators: name: University Of British Columbia
Publisher: name: Vancouver : University of British Columbia
Year: 2017

description: Announcement of courses for the 36th summer session at the University of British Columbia, taking place from July 4th to August 19th, 1955. Contains course schedule, course descriptions and details, fees, and other information about the session.
Bound and continuum-embedded states of cyanopolyyne anions
Creators: name: Skomorowski, Wojciech
name: Gulania, Sahil
name: Krylov, Anna I.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Cyanopolyyne anions were among the first anions discovered in the interstellar medium. The discovery have raised questions about routes of formation of these anions in space. Some of the proposed mechanisms assumed that anionic excited electronic states, either metastable or weakly bound, play a key role in the formation process. Verification of this hypothesis requires detailed knowledge of the electronic states of the anions. Here we investigate bound and continuum states of four cyanopolyyne anions, CN$^-$, C$_3$N$^-$, C$_5$N$^-$, and C$_7$N$^-$, by means of ab initio calculations. We employ the equation-of-motion coupled-cluster method augmented with complex absorbing potential. We predict that already in CN$^-$, the smallest anion in the family, there are several low-lying metastable states of both singlet and triplet spin symmetry. These states, identified as shape resonances, are located between 6.3-8.5 eV above the ground state of the anion (or 2.3-4.5 eV above the ground state of the parent radical) and have widths of a few tenths of eV up to 1 eV. We analyze the identified resonances in terms of leading molecular orbital contributions and Dyson orbitals. As the carbon chain length increases in the C$_{2n+1}$N$^-$ series, these resonances gradually become stabilized and eventually turn into stable valence bound states. The trends in energies of the transitions leading to both resonance and bound excited states can be rationalized by means of the Hückel model. Apart from valence excited states, some of the cyanopolyynes can also support dipole bound states and dipole stabilized resonances, owing to a large dipole moment of the parent radicals in the lowest $^2Σ^+$ state. We discuss the consequences of open-shell character of the neutral radicals on the dipole-stabilized states of the respective anions.
Additional file 1: of Team interventions in acute hospital contexts: a systematic search of the literature using realist synthesis
Creators: name: U. Cunningham
name: M. Ward
name: A. De BrĂşn
name: E. McAuliffe
Publisher: name: figshare
Year: 2018
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Hyperlink 1. Data extrapolation template for studies included in synthesis. Hyperlink 2. Teamwork mechanisms identified. (DOCX 70 kb)
Recollapse of the closed Tolman spacetimes
Creators: name: Burnett, Gregory A.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The closed-universe recollapse conjecture is studied for the spherically symmetric spacetimes. It is proven that there exists an upper bound to the lengths of timelike curves in any Tolman spacetime that possesses $S^3$ Cauchy surfaces and whose energy density is positive. Furthermore, an explicit bound is constructed from the initial data for such a spacetime.
description: 25 pages, REVTeX, NCSU-MP-9301
Serum messenger RNA, protein biomarkers and metabolomic profiling in diabetes mellitus
Creators: name: Tisdall, Ana Rakovac
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: While there is consensus on what biological parameters are consistent with diagnosis of diabetes, there is a scarcity of biomarkers which might identify different biochemical phenotypes of disease, underlying β cell mass or propensity to complications in diabetes. The studies presented in this thesis were undertaken based on observations from our research group’s previous study, which identifed differentially expressed mRNAs in extracellular medium of glucose-responsive vs. glucose-non-responsive cell lines. As level of expression of mRNAs was dependent on glucose responsiveness and cell mass, we aimed to investigate whether similar mRNA expression pattern changes would be observed in human serum in patients with known diabetes. We collected samples from patients with impaired fasting glucose, impaired glucose tolerance, newly diagnosed type 2 diabetes, newly diagnosed type 1 diabetes, poorly controlled type 2 diabetes and long-standing type 1 diabetes as well as healthy controls. In this work, I present findings from studies on patients newly diagnosed with type 2 diabetes, newly diagnosed type 1 diabetes and long-standing diabetes, compared to their healthy controls. We have not found differential expression of mRNA identified in the cell lines study in our newly diagnosed type 2 diabetes patients and the research group’s decision was not to extend mRNA studies to other groups of subjects, which may be attempted with resolution of current financial constraints. We also examined sera of patients with type 1 diabetes with proteomic and novel metabolomic methods. Proteomic analysis identified down-regulation of anticoagulant protein S in patients with newly diagnosed type 1 diabetes, but no reported thrombotic events. While proteomics also identified reduced levels of vitronectin in patients with established type 1 diabetes, this is of unknown signficance. In metabolomic analysis, the most consistently altered metabolic pathway was the caffeine metabolism, with five caffeine metabolites being significantly down-regulated in patients with newly diagnosed type 1 diabetes, possibly indicating increased caffeine consumption by controls. Other pathways significantly altered were those of carbohydrate and lipid metabolism. 1,5-anhydroglucitol, a known marker of glycemic control, was unsurprisingly significantly down-regulated in patients with newly diagnosed type 1 diabetes, in conjunction with significantly raised glucose levels in these patients. Lipid metabolites were were lower in patients with type 1 diabetes than in controls; this was coupled with higher total and LDL cholesterol in controls than in patients with type 1 diabetes. Therefore it is unknown if changes in lipid metabolites are reflective of type 1 diabetes, or due to the high cholesterol in control samples.
Mitigative properties of aqueous Syzygium cumini seed extract against heavy metal-induced genotoxicity in vegetables
Creators: name: Patil, Sauvit
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 410501
subject: Environmental biogeochemistry
classificationCode: 310599
subject: Genetics not elsewhere classified

description:  This research proposal investigates the genotoxic implications of a vegetable extract containing heavy metals, along with the potential remedial effects of jamun seed extract on DNA damage. Using the Allium cepa root model and Comet Assay method, the study examines the extent of DNA damage in onion roots exposed to the vegetable extract. The project comprises four stages: sample acquisition and treatment, meticulous comet assay execution, lysis, electrophoresis, and staining procedures, culminating in data analysis. By comparing onion roots exposed to the vegetable extract alone and those co-exposed to the vegetable and jamun seed extracts, the study aims to understand genotoxicity and promote environmental awareness. This research contributes to our understanding of environmental pollutants' impact on DNA integrity, emphasizing the need for eco-conscious practices.
Mid-infrared optics using dielectrics with refractive indices below unity
Creators: name: Shahsafi, Alireza
name: Xiao, Yuzhe
name: Salman, Jad
name: Gundlach, Bradley S.
name: Wan, Chenghao
name: Roney, Patrick J.
name: Kats, Mikhail A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Conventional transparent materials at optical frequencies have refractive index values (n) greater than unity -- most commonly between about 1 and 4. This paper explores optical phenomena made possible by using materials with refractive indices less than unity. We focus primarily on fused silica (SiO2), a polar dielectric with strong phonon resonances in the mid infrared that result in a spectral region in which n < 1 with modest optical loss. Using this ubiquitous easy-to-deposit material, we demonstrate infrared-frequency external reflection, frustrated external reflection, and direct coupling to surface plasmon polaritons from free space. Our work suggests that materials with refractive indices below unity can bring significant new functionality to optical devices.
description: Main text and supplementary information
Density Fluctuations in a Polar Coronal Hole
Creators: name: Hahn, Michael
name: D'Huys, Elke
name: Savin, Daniel Wolf
Publisher: name: arXiv
Year: 2018
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We have measured the root-mean-square (RMS) amplitude of intensity fluctuations, $ΔI$, in plume and interplume regions of a polar coronal hole. These intensity fluctuations correspond to density fluctuations. Using data from the \rev{Sun Watcher using Active Pixel System detector and Image Processing} (SWAP) on \textit{Project for Onboard Autonomy (Proba2)}, our results extend up to a height of about 1.35~$R_{\sun}$. One advantage of the RMS analysis is that it does not rely on a detailed evaluation of the power spectrum, which is limited by noise levels to low heights in the corona. The RMS approach can be performed up to larger heights where the noise level is greater, provided that the noise itself can be quantified. At low heights, both the absolute $ΔI$, and the amplitude relative to the mean intensity, $ΔI/I$, decrease with height. However, starting at about 1.2~$R_{\sun}$ $ΔI/I$ increases, reaching 20--40\% by 1.35~$R_{\sun}$. This corresponds to density fluctuations of $Δn_{\mathrm{e}}/n_{\mathrm{e}} \approx$~10--20\%. The increasing relative amplitude implies that the density fluctuations are generated in the corona itself. One possibility is that the density fluctuations are generated by an instability of Alfvén waves. This generation mechanism is consistent with some theoretical models and with observations of Alfvén wave amplitudes in coronal holes. Although we find that the energy of the observed density fluctuations is small, these fluctuations are likely to play an important indirect role in coronal heating by promoting the reflection of Alfvén waves and driving turbulence.
description: Accepted for Astrophysical Journal
Announcement of the Summer Session Supplement to Calendar 1955-1956 Thirty-seventh Session: July 3rd to August 17th, 1956
Creators: name: University Of British Columbia
Publisher: name: Vancouver : University of British Columbia
Year: 2017

description: Announcement of courses for the 37th summer session at the University of British Columbia, taking place from July 3rd to August 17th, 1956. Contains course schedule, course descriptions and details, fees, and other information about the session.
Life Beyond PTF
Creators: name: Bellm, Eric C.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: In March 2017, the Intermediate Palomar Transient Factory (iPTF) ceased operations. I take this occasion to review the scientific returns from iPTF and its predecessor survey, the Palomar Transient Factory (PTF), and to summarize the lessons learned. Succeeding iPTF on the Palomar Observatory 48-inch Schmidt telescope is the Zwicky Transient Facility (ZTF), a new survey with an order of magnitude faster survey speed that is now being commissioned. I describe the design and scientific rationale for ZTF. ZTF is prototyping new alert stream technologies being explored by the Large Synoptic Survey Telescope (LSST) to distribute millions of transient alerts per night to downstream science users. I describe the design of the alert system and discuss it in the context of the wider LSST and community broker ecosystem.
description: 6 pages, 1 figure; Invited review to appear in Proceedings of IAU Symposium 339, "Southern Horizons in Time Domain Astronomy"
Fluid turbulence and eddy viscosity in relativistic heavy-ion collisions
Creators: name: Romatschke, Paul
Publisher: name: arXiv
Year: 2007
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The eddy viscosity for a turbulent compressible fluid with a relativistic equation of state is derived. Compressibility allows for sound modes, but the eddy viscosity in the shear mode is found to be the same as for incompressible fluids. For two space dimensions (which is the relevant case for the dynamics of relativistic heavy-ion collisions) the eddy viscosity in the shear mode is negative, reducing the effective viscosity below its microscopic value. This could explain the tiny viscosity found at RHIC. Implications for the experimentally accessible elliptic flow coefficient at the LHC are speculated on.
description: 4 pages, 1 figure, uses revtex4
Quantitative Proteomic Analysis and Gene Expression Profiling Microarray Re-analysis of Uveal Melanoma
Creators: name: Pathma Ramasamy
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Uveal melanoma (UM) is the most common primary intraocular malignancy in adults and 40% develop fatal metastatic disease. Compared to tumours with chromosome 3 disomy, monosomy 3 tumours will nearly exclusively develop metastasis. To identify differentially expressed proteins, quantitative label-free LC-MS proteomic profiling of 8 primary UM tissues from patients with metastasis (M) and 8 from patients without metastasis (NM) was performed. Fifty proteins with ≥ 3 peptides matched and p < 0.05 between the two patient groups were differentially expressed. Thioredoxin-dependant peroxidase reductase (PRDX3) was upregulated and cytosolic non-specific dipeptidase (CNDP2) was downregulated in M compared to NM. To identify differentially expressed genes, bioinformatic reanalysis of publically available gene expression microarray datasets of 63 primary UM tumours was performed. Samples with confounding factors (chromosome 3 disomy with metastasis and chromosome 3 monosomy without metastasis) and outlying samples in principal component analysis were excluded. Eleven monosomy 3 tumours with metastasis (M3M) versus 9 disomy 3 tumours without metastasis (D3NM) were compared. A total of 449 differentially expressed genes with fold change of ≥ 1.3 and p < 0.05 were found between the two patient groups. Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2) was upregulated and contactin 3 (CNTN3) was downregulated in M3M compared to D3NM. Pilot immunohistochemical (IHC) study of PRDX3, CNDP2, SIPA1L2 and CNTN3 expression in 13 full-face formalin-fixed paraffin-embedded tissues of patients that did (mUM) and 13 that did not develop metastasis (nmUM) showed a trend toward higher expression of PRDX3 in mUM compared to nmUM (p: 0.061). Expression of CNDP2, SIPA1L2 and CNTN3 were not significant (p: 0.752, p: 0.094 and p: 0.099 respectively). IHC of PRDX3 in tissue microarray samples of 55 mUM and 37 nmUM tumours showed statistically significant difference in expression between mUM and nmUM (p: 0.001). Significant difference in survival was found based on high and low expression of PRDX3 (67.61 vs. 130.64 months respectively, p: 0.013). In conclusion, differential proteomic analysis of primary UM tissues from patients with and without metastasis has identified PRDX3 to be associated with metastasis and poor survival.
Mitigative properties of aqueous Syzygium cumini seed extract against heavy metal-induced genotoxicity in vegetables
Creators: name: Patil, Sauvit
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 410501
subject: Environmental biogeochemistry
classificationCode: 310599
subject: Genetics not elsewhere classified

description:  This research proposal investigates the genotoxic implications of a vegetable extract containing heavy metals, along with the potential remedial effects of jamun seed extract on DNA damage. Using the Allium cepa root model and Comet Assay method, the study examines the extent of DNA damage in onion roots exposed to the vegetable extract. The project comprises four stages: sample acquisition and treatment, meticulous comet assay execution, lysis, electrophoresis, and staining procedures, culminating in data analysis. By comparing onion roots exposed to the vegetable extract alone and those co-exposed to the vegetable and jamun seed extracts, the study aims to understand genotoxicity and promote environmental awareness. This research contributes to our understanding of environmental pollutants' impact on DNA integrity, emphasizing the need for eco-conscious practices.
Additional file 1: of Acceptability and accessibility of child nutrition interventions: fathersâ perspectives from survey and interview studies
Creators: name: Jansen, Elena
name: Harris, Holly
name: Daniels, Lynne
name: Thorpe, Karen
name: Rossi, Tony
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Overview of constructs assessed in Study 1, including their respective items, response scales and internal reliability. (DOCX 19Â kb)
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Cart. 185 (11 H 70), f. 0165v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Archives départementales de la Côte-d'Or, Cart. 185 (11 H 70), f. 0165v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Archives départementales de la Côte-d'Or, Cart. 185 (11 H 70), f. 0165v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
The impact of innate ability and objective scoring methods on proficiency based training in minimally invasive surgery.
Creators: name: Buckley, Christina
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Background: The attainment of technical competence and accurate performanceassessment of surgical trainees for surgical procedures are the fundamentalcomponents of a proficiency-based surgical training programme. We hypothesised thataptitude may directly affect one’s ability to successfully complete the learning curve forminimally invasive procedures. Aim: The principle aim of this thesis was evaluate the impact of innate ability upon therate at which a surgical novice can achieve proficiency in index and advancedlaparoscopic procedures. Our secondary aim was to develop new objective methods oftechnical skills assessment for a proficiency-based programme. Materials & Methods: We tested medical students (surgical novices) with disparateaptitude consecutively until they achieved proficiency in laparoscopic appendicectomyand laparoscopic suturing using objective and subjective scoring methods. Wedeveloped objective scoring methods by designing a new zone metric to assesslaparoscopic suturing and also a mathematical formula to provide meaningful metrics scores on the laparoscopic simulator ProMIS. Results: The results demonstrated that surgical novices with low aptitude took twice as long to reach proficiency targets. Aptitude predicted superior baseline performance in medical students. There is a group of surgical candidates who are unable to achieve proficiency despite repeated practice. It was shown that a new zone metric could be used to assess laparoscopic suturing. Finally we successfully developed a scoring method, which provides meaningful user scores on the ProMIS simulator. Conclusion: High aptitude is directly related to a rapid attainment of proficiency. It is likely that surgical trainees self select in surgery based on innate ability. The new zone metric and formulated scoring systems are valid tools for assessing laparoscopic tasks and provide meaningful scores. These findings have implications for developing a proficiency based training system according to a trainees natural ability.
Superconducting proximity effect in a topological insulator using Fe(Te,Se)
Creators: name: Zhao, He
name: Rachmilowitz, Bryan
name: Ren, Zheng
name: Han, Ruobin
name: Schneeloch, J.
name: Zhong, Ruidan
name: Gu, Genda
name: Wang, Ziqiang
name: Zeljkovic, Ilija
Publisher: name: arXiv
Year: 2018
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Interest in the superconducting proximity effect has recently been reignited by theoretical predictions that it could be used to achieve topological superconductivity. Low-T$_{c}$ superconductors have predominantly been used in this effort, but small energy scales of ~1 meV have hindered the characterization of the emergent electronic phase, limiting it to extremely low temperatures. In this work, we use molecular beam epitaxy to grow topological insulator Bi$_{2}$Te$_{3}$ in a range of thicknesses on top of a high-T$_{c}$ superconductor Fe(Te,Se). Using scanning tunneling microscopy and spectroscopy, we detect Δ$_{ind}$ as high as ~3.5 meV, which is the largest reported gap induced by proximity to an s-wave superconductor to-date. We find that Δ$_{ind}$ decays with Bi$_{2}$Te$_{3}$ thickness, but remains finite even after the topological surface states had been formed. Finally, by imaging the scattering and interference of surface state electrons, we provide a microscopic visualization of the fully gaped Bi$_{2}$Te$_{3}$ surface state due to Cooper pairing. Our results establish Fe-based high-T$_{c}$ superconductors as a promising new platform for realizing high-T$_{c}$ topological superconductivity.
Announcement of the Summer Session Supplement to Calendar 1956-1957 Thirty-eighth Session: July 2nd to August 16th, 1957
Creators: name: University Of British Columbia
Publisher: name: Vancouver : University of British Columbia
Year: 2017

description: Announcement of courses for the 38th summer session at the University of British Columbia, taking place from July 2nd to August 16th, 1957. Contains course schedule, course descriptions and details, fees, and other information about the session.
Evidence for Hco+ Infall toward T Tauri?
Creators: name: van Langevelde, Huib Jan
name: van Dishoeck, Ewine F.
name: Blake, Geoffrey A.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: High spectral and spatial resolution observations of the HCO+ molecule toward the T Tau binary system obtained with the Owens Valley Millimeter Array reveal a broad emission line profile (V_LSR = 7.2 km/s, width = 2.0 km/s) upon which a narrow, redshifted absorption feature (V_LSR = 8.5 km/s, width +/- 0.5 km/s) is superposed. One possible interpretation of the absorption is that it arises from infall of molecular cloud envelope material onto the immediate circumbinary region, which would imply that large scale dynamic accretion processes are still active well into the optically visible stages of star formation. Provided the mass is deposited at radii sufficiently close to the young stars, estimates of the accretion rates indicate that infall may add enough material to the system to account for the FU~Orionis type flares recently observed in T~Tau in =< 100 yr.
description: 9 pages, uuencoded PostScript file, including figures