cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Risk and safety profile in checkpoint inhibitors on non-small-cel lung cancer: A systematic review
Creators: name: Majernikova, Sara Maria
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Cancer

description: Treating non-small-cell lung cancer (NSCLC) has gained increased importance in recent years due to the high mortality rate and dismal five-year survival rate. Immune checkpoint inhibitors (ICI) are a promising approach with exceptional outcomes in NSCLC thanks to the antigenic nature of cells. Conversely, immune system over-stimulation with ICI is a double-edged sword that can lead to various negative effects ranging from mild to life-threatening. This review explores current breakthroughs in nanoparticle-based ICI and their limitations. The PubMed, Scopus and Web of Science were examined for relevant publications. Thirty-eight trials (N = 16,781) were included in the analyses. The mixed effects analyses on quantifying the treatment effect contributed significantly to the subgroups within studies for ICI treatment effect. Models confirmed ICI’s higher impact on treatment effectivity and the decrease in respondents’ mortality compared to conventional treatment regiments. ICI might be used as first-line therapy due to their proven effectiveness and safety profile.
Principio pattizio e garanzia dell’eguaglianza tra le confessioni religiose: il punto di vista della Consulta nella sentenza n. 52 del 2016
Creators: name: Parisi, Marco
Publisher: name: Università degli Studi di Milano
Year: 2017
Subjects: Concordati, intese e altri accordi

description: Il contributo, sottoposto a valutazione, è destinato alla pubblicazione nel volume a cura di M. Parisi, Bilateralità pattizia e diritto comune dei culti. A proposito della sentenza n. 52/2016, Editoriale Scientifica, Napoli, 2017.
SOMMARIO: 1. Introduzione - 2. L’attuazione del principio pattizio tra esigenze politiche del Governo e tutela giurisdizionale dei diritti - 3. Diniego di avvio delle trattative, qualificazione religiosa dei soggetti istanti e uguale libertà: i nodi problematici e le soluzioni.
ABSTRACT: The judgment no. 52/16 of the Constitutional Court has related to a conflict of powers between branches of State, in particular between the Council of Ministers and the Supreme Court, canceling the judgment of the Supreme Court (judgment no. 16305, June 28, 2013) with which it was established the syndicatability to the courts of the government resolution which had been denied to the Union of Atheists and Rationalist Agnostics the opening of negotiations for the signing of the agreement, in accordance with Article 8, third paragraph, of the Constitution. In reaching that conclusion, the Constitutional Court considered necessary some considerations relating to the nature and the meaning that, in our constitutional system, assume the agreement for the regulation of relations between the state and the non-Catholic religious denominations. At the same time, the Judge of the Laws has also been called upon to interpret the first paragraph of Article 8, which, in stating that all religions are equally free before the law, exclude that the State can foster the expansion of a religious group compared to the others.
description: Stato, Chiese e pluralismo confessionale, 2017: 10 aprile
sj-docx-1-rop-10.1177_0734371X21994631 – Supplemental material for It’s Not All the Same: Implemented and Perceived HR Practices in the Volunteer Context
Creators: name: Walk, Marlene
name: Scott, Charity
name: Littlepage, Laura
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160607 International Relations
subject: FOS: Political science
subject: 160509 Public Administration

description: Supplemental material, sj-docx-1-rop-10.1177_0734371X21994631 for It’s Not All the Same: Implemented and Perceived HR Practices in the Volunteer Context by Marlene Walk, Charity Scott and Laura Littlepage in Review of Public Personnel Administration
Seroprevalence of IgG antibodies against pertussis toxin in the Chinese population: A systematic review and meta-analysis
Creators: name: Zhu, Yao
name: Zhang, Wanting
name: Hu, Jie
name: Luo, Shuying
name: Zhou, Yang
name: Tang, Xuewen
name: Yan, Rui
name: Deng, Xuan
name: He, Hanqing
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Pertussis is a vaccine-preventable infectious disease; however, data on pertussis antibody levels in a nationwide population are still limited in China. We aimed to pool the seropositivity rates of IgG antibodies against pertussis toxin (PT-IgG) across the country. We systematically searched PubMed, Web of Science, Embase, and the China National Knowledge Infrastructure Database for studies published between January 1, 2010, and June 30, 2023. Studies reporting the seroprevalence of PT-IgG among a healthy Chinese population were included. Pooled estimates were obtained using random-effects meta-analyzes. The meta-analysis included 39 studies (47,778 participants) reporting anti-PT IgG seropositivity rates. The pooled rate for all ages was 7.06% (95% CI, 5.50%-9.07%). Subgroup analyzes showed rates ranging from 6.36% to 12.50% across different age groups. This meta-analysis indicated a low anti-PT IgG seropositivity rate in the Chinese population, particularly among school-aged children and young adults. This finding underscores the urgent need to refine immunization strategies.
Supplemental Material, sj-pdf-1-ehp-10.1177_0163278721992831 - Development of the Teaching Interpersonal Skills for Telehealth Checklist
Creators: name: Henry, Beverly W.
name: Billingsly, Danica
name: Block, Derryl E.
name: Ehrmann, Joseph
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111099 Nursing not elsewhere classified
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental Material, sj-pdf-1-ehp-10.1177_0163278721992831 for Development of the Teaching Interpersonal Skills for Telehealth Checklist by Beverly W. Henry, Danica Billingsly, Derryl E. Block and Joseph Ehrmann in Evaluation & the Health Professions
Special Folding of Quivers and Cluster Algebras
Creators: name: Kaufman, Dani
Publisher: name: arXiv
Year: 2023
Subjects: subject: Combinatorics (math.CO)
subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: 13F60 (Primary), 05E40 (Secondary)

description: We give a precise definition of folded quivers and folded cluster algebras. We give many examples of including some with finite mutation structure that do not have analogues in the unfolded cases. We relate these examples to the finite mutation type quivers $X_6$ and $X_7$. We also construct a folded cluster algebra associated to triangulations of punctured surface which allow for triangulations self-folded triangles. We give a simple construction of a folded cluster algebra for which the cluster complex is a generalized permutohedron.
description: 18 pages, 25 figures
sj-pdf-1-opp-10.1177_1078155221992841 - Supplemental material for Robotic chemotherapy compounding: A multicenter productivity approach
Creators: name: Riestra, Ana C
name: López-Cabezas, Carmen
name: Jobard, Marion
name: Mertxe Campo
name: Tamés, María J
name: Marín, Ana M
name: Brandely-Piat, Marie L
name: Carcelero-Viladomat, Esther
name: Batista, Rui
name: Cajaraville, Gerardo
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, sj-pdf-1-opp-10.1177_1078155221992841 for Robotic chemotherapy compounding: A multicenter productivity approach by Ana C Riestra, Carmen López-Cabezas, Marion Jobard, Mertxe Campo, María J Tamés, Ana M Marín, Marie L Brandely-Piat, Esther Carcelero-Viladomat, Rui Batista and Gerardo Cajaraville in Journal of Oncology Pharmacy Practice
Additional file 3 of N4-acetylcytidine modification of ITGB5 mRNA mediated by NAT10 promotes perineural invasion in pancreatic ductal adenocarcinoma
Creators: name: Huang, Leyi
name: Lu, Yanan
name: He, Rihua
name: Guo, Xiaofeng
name: Zhou, Jiajia
name: Fu, Zhiqiang
name: Li, Jingwen
name: Liu, Jianping
name: Chen, Rufu
name: Zhou, Yu
name: Zhou, Quanbo
Publisher: name: figshare
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Supplementary Material 3
E05637: Venantius Fortunatus writes a poem to commemorate the construction of a church in Toulouse (south-west Gaul) of *Saturninus (bishop and martyr of Toulouse, S00289) by duke Launebod of Toulouse, with his wife Beretrude, in 565/576. Poem 2.8, written in Latin in Gaul, 565/576.
Creators: name: Kwojtalik
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: Venantius Fortunatus, Poems 2.8 (De Launebode qui aedificavit templum Sancti Saturnini, 'On Launebodis, who built the church of Saint Saturninus'), 19-22

The poem opens with praise of Saturninus and a reference to his martyrdom by being tied to a bull and dragged through the city.

Sed locus ille quidem, quo sanctus vincula sumpsit,
 nullius templi fultus honore fuit. 20
Launebodis enim post saecula longa, ducatum
 dum gerit, instruxit culmina sancta loci.
Quod nullus veniens Romana gente fabrivit,
 hoc vir barbarica prole peregit opus,
coniuge cum propria Berethrude, clara decore 25
 pectore quae blando clarior ipsa nitet.

'But yet the place where the holy man [Saturninus] took on his bonds was not distinguished by the honor of a church. So after long ages Launebod, in the office of duke, constructed a sacred building on the spot. The work which no one descended from the Roman race performed, a man of barbarian ancestry brought to completion with his wife Beretrude, distinguished by her beauty, but still more brilliant by her sweetness of heart.'

The poem ends with praise for Beretrude's piety and charity, and for Launebod's merits and nobility.

Text: Leo 1881, 37. Translation: Roberts 2017, 89.
Almost optimal manipulation of a pair of alternatives
Creators: name: Szybowski, Jacek
name: Kułakowski, Konrad
name: Ernst, Sebastian
Publisher: name: arXiv
Year: 2023
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: The role of an expert in the decision-making process is crucial, as the final recommendation depends on his disposition, clarity of mind, experience, and knowledge of the problem. However, the recommendation also depends on their honesty. But what if the expert is dishonest? Then, the answer on how difficult it is to manipulate in a given case becomes essential. In the presented work, we consider manipulation of a ranking obtained by comparing alternatives in pairs. More specifically, we propose an algorithm for finding an almost optimal way to swap the positions of two selected alternatives. Thanks to this, it is possible to determine how difficult such manipulation is in a given case. Theoretical considerations are illustrated by a practical example.
description: 18 pages
Additional file 1 of Targeting focal adhesion kinase boosts immune response in KRAS/LKB1 co-mutated lung adenocarcinoma via remodeling the tumor microenvironment
Creators: name: Qiao, Meng
name: Zhou, Fei
name: Liu, Xinyu
name: Jiang, Tao
name: Wang, Haowei
name: Li, Xuefei
name: Zhao, Chao
name: Cheng, Lei
name: Chen, Xiaoxia
name: Ren, Shengxiang
name: Wang, Zaiqi
name: Zhou, Caicun
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Table S1. Antibodies used in flow cytometry.
E05638: Venantius Fortunatus, in a poem On the basilica of *George (soldier and martyr, S00259) in Mainz (north-east Gaul), praises Sidonius, bishop of Mainz, as its founder, in 530/550. Poem 2.12, written in Latin in Gaul, 565/576.
Creators: name: Kwojtalik
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: Venantius Fortunatus, Poems 2.12 (De basilica Sancti Georgi, 'On the church of Saint George')

Martyris egregii pollens micat aula Georgi,
 cuius in hunc mundum spargitur altus honor:
carcere caede fame vinclis site frigore flammis
 confessus Christum duxit ad astra caput;
qui virtute potens orientis in axe sepultus 5
 ecce sub occiduo cardine praebet opem.
Ergo memento preces et reddere vota, viator:
 obtinet hic meritis quod petit alma fides.
Condidit antistes Sidonius ista decenter,
 proficiant animae quae nova templa suae. 10

'The mighty church of the noble martyr George is aglow, a saint whose high honor spreads as far as this realm. Through prison, beatings, hunger, chains, thirst, cold, and flames, making confession of Christ, he raised his head up to the stars. (5) Strong in his powers, though buried in eastern climes, behold, here under western skies he proffers his aid. Therefore be mindful, traveler, to give him your prayers and your vows; here true faith secures by his merits the petitions it makes. Bishop Sidonius founded this building with fitting display; may this new church win due profit for his soul.'

Text: Leo 1881, 41. Translation: Roberts 2017, 101.
sj-pdf-1-ctj-10.1177_1740774520976561 – Supplemental material for Dynamic methods for ongoing assessment of site-level risk in risk-based monitoring of clinical trials: A scoping review
Creators: name: Cragg, William J
name: Hurley, Caroline
name: Yorke-Edwards, Victoria
name: Stenning, Sally P
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-ctj-10.1177_1740774520976561 for Dynamic methods for ongoing assessment of site-level risk in risk-based monitoring of clinical trials: A scoping review by William J Cragg, Caroline Hurley, Victoria Yorke-Edwards and Sally P Stenning in Clinical Trials
E05639: Venantius Fortunatus, in a poem on an oratory built by a certain 'Trasaricus', mentions its relics of *Peter (the Apostle, S00036), *Paul (the Apostle, S00008), *Martin (ascetic and bishop of Tours, ob. 397, S00050) and *Remigius (bishop of Reims, ob. c. 533, S00456); perhaps in Toul (eastern Gaul), in the mid-6th c. Poem 2.13, written in Latin in Gaul, 565/576.
Creators: name: Kwojtalik
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: Venantius Fortunatus, Poems 2.13 (De oratorio Trasarici, 'On the oratory of Trasaricus')

Lucida perspicui nituerunt limina templi,
 quo capit haud dubiam spem veneranda fides.
Haec est aula Petri, caelos qui clave catenat,
 substitit et pelagus quo gradiente lapis.
Sedibus his Paulus habitat, tuba gentibus una, 5
 et qui praedo prius, hic modo praeco manet.
Martini domus est, Christum qui vestit egentem,
 regem tiro tegens et homo iure deum.
Ecce sacerdotis sacri micat aula Remedi
 qui tenebras mundi liquit et astra tenet. 10
Cultor opime dei templum, Trasarice, locasti:
 has cui persolvis reddet amator opes.

'The threshold of the radiant church has won a brilliant luster, where pious faith receives hopes that brook no doubt. This is the hall of Peter, who confines the sky with his keys, and at whose step sea became solid stone. (5) Paul occupies this abode too, sole clarion to the nations; a man who once was a persecutor, but now is a preacher. It is the house of Martin, who clothed Christ as a poor man, a raw recruit cloaking a king and a man rightly covering God. (9) See, too, the hall of the holy bishop Remedius is aglow, who has left the darkness of the world to occupy the stars. Trasaricus, noble devotee of God, you have set up a church; this wealth you expend, its recipient will pay back to you in love.'

Text: Leo 1881, 41-42. Translation: Roberts 2017, 103.
The impact of the COVID-19 pandemic and the free vaccination policy on seasonal influenza vaccination uptake among older adults in Ningbo, Eastern China
Creators: name: Ye, Lixia
name: Chen, Jieping
name: Mei, Qiuhong
name: Sun, Yexiang
name: Yang, Tianchi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: In 2020–21, during the COVID-19 pandemic, a free influenza vaccination program was initiated among the elderly residents in Ningbo, China. The impact of the COVID-19 pandemic and free vaccination policy on influenza vaccine uptake needs to be evaluated. The influenza vaccine uptake among individuals born before 31 December, 1962 from 2017–18 to 2022–23 season in Ningbo was analyzed. Multivariate logistic regressions were used to estimate the impact of the COVID-19 pandemic and free vaccination policy. Our analysis included an average of 1,856,565 individuals each year. Influenza vaccination coverage increased from 1.14% in 2017–18 to 33.41% in 2022–23. The vaccination coverage among the free policy target population was 50.03% in 2022–23. Multivariate analysis showed that free vaccination policy increased influenza vaccine uptake most (OR = 11.99, 95%CI: 11.87–12.11). The initial phase of the pandemic was associated with a positive effect on influenza vaccination (OR = 2.09, 95%CI: 2.07–2.12), but followed by a negative effect in the subsequent two seasons(2021–22: OR = 0.75, 95%CI: 0.73–0.76; 2022–23: OR = 0.40, 95%CI: 0.39–0.40). COVID-19 vaccination in the current season was a positive predictor of influenza vaccine uptake while not completing booster COVID-19 vaccination before was negative predictor in 2022–23. Having influenza vaccine history and having ILI medical history during the last season were also positive predictors of influenza vaccine uptake. Free vaccination policies have enhanced influenza vaccination coverage among elderly population. The COVID-19 pandemic plays different roles in different seasons. Our study highlights the need for how to implement free vaccination policies targeting vulnerable groups with low vaccination coverage.
Speck: A Smart event-based Vision Sensor with a low latency 327K Neuron Convolutional Neuronal Network Processing Pipeline
Creators: name: Richter, Ole
name: Xing, Yannan
name: De Marchi, Michele
name: Nielsen, Carsten
name: Katsimpris, Merkourios
name: Cattaneo, Roberto
name: Ren, Yudi
name: Hu, Yalun
name: Liu, Qian
name: Sheik, Sadique
name: Demirci, Tugba
name: Qiao, Ning
Publisher: name: arXiv
Year: 2023
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: Machine Learning (cs.LG)
subject: Image and Video Processing (eess.IV)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Edge computing solutions that enable the extraction of high-level information from a variety of sensors is in increasingly high demand. This is due to the increasing number of smart devices that require sensory processing for their application on the edge. To tackle this problem, we present a smart vision sensor System on Chip (SoC), featuring an event-based camera and a low-power asynchronous spiking Convolutional Neural Network (sCNN) computing architecture embedded on a single chip. By combining both sensor and processing on a single die, we can lower unit production costs significantly. Moreover, the simple end-to-end nature of the SoC facilitates small stand-alone applications as well as functioning as an edge node in larger systems. The event-driven nature of the vision sensor delivers high-speed signals in a sparse data stream. This is reflected in the processing pipeline, which focuses on optimising highly sparse computation and minimising latency for 9 sCNN layers to 3.36μs for an incoming event. Overall, this results in an extremely low-latency visual processing pipeline deployed on a small form factor with a low energy budget and sensor cost. We present the asynchronous architecture, the individual blocks, and the sCNN processing principle and benchmark against other sCNN capable processors.
description: accepted and presented at 28th IEEE International Symposium On Asynchronous Circuits and Systems (ASYNC) 2023
Additional file 4 of N4-acetylcytidine modification of ITGB5 mRNA mediated by NAT10 promotes perineural invasion in pancreatic ductal adenocarcinoma
Creators: name: Huang, Leyi
name: Lu, Yanan
name: He, Rihua
name: Guo, Xiaofeng
name: Zhou, Jiajia
name: Fu, Zhiqiang
name: Li, Jingwen
name: Liu, Jianping
name: Chen, Rufu
name: Zhou, Yu
name: Zhou, Quanbo
Publisher: name: figshare
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Supplementary Material 4
Supplemental Material, sj-pdf-1-cat-10.1177_1076029620976913 - The Evaluation of APTT Reagents in Reference Plasma, Recombinant FVIII Products; Kovaltry® and Jivi® Using CWA, Including sTF/7FIX Assay
Creators: name: Wada, Hideo
name: Shiraki, Katsuya
name: Matsumoto, Takeshi
name: Kohshi Ohishi
name: Shimpo, Hideto
name: Sakano, Yumi
name: Nishii, Hiroko
name: Motomu Shimaoka
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Cardiology
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental Material, sj-pdf-1-cat-10.1177_1076029620976913 for The Evaluation of APTT Reagents in Reference Plasma, Recombinant FVIII Products; Kovaltry® and Jivi® Using CWA, Including sTF/7FIX Assay by Hideo Wada, Katsuya Shiraki, Takeshi Matsumoto, Kohshi Ohishi, Hideto Shimpo, Yumi Sakano, Hiroko Nishii and Motomu Shimaoka in Clinical and Applied Thrombosis/Hemostasis
Ibodies: Modular Synthetic Polymer Antibodies
Creators: name: Knedl?K, Tomas
Publisher: name: Zenodo
Year: 2016
Subjects: antibody mimetics
HPMA copolymer
iBodies
protein targeting

description: The introduction of monoclonal antibodies, specifically targeting  biologically important proteins, revolutionized life sciences and  subsequently clinical diagnostics as well as therapeutics. Nowadays,  antibodies represent indispensable tools for researchers. Despite this  extraordinary success, the use of antibodies involves also several  disadvantages, such as difficult chemical modification, high production  costs, and limited stability. To tackle these limitations, we set out to  develop an alternative recognition tool capable of binding proteins of  interest - polymer-based antibody mimetics (iBodies).
 iBodies consist of a N-(2-hydroxypropyl)methacrylamide  (HPMA) copolymer decorated with different small ligands that function  as targeting ligands, affinity anchors and imaging probes. As targeting  ligands, specific enzyme inhibitors represent the perfect choice. As an  affinity tag and imaging probe, we chose biotin and the fluorophore  ATTO488, respectively (Fig. 1). We prepared specific iBodies targeting  several biologically relevant proteins with known inhibitors, namely  glutamate carboxypeptidase II (GCPII), HIV?1 protease, carbonic  anhydrase IX, aspartic proteases, and His?tagged proteins. We  successfully used iBodies for enzyme inhibition and subsequently also  for protein isolation, quantification and immobilization as well as live  cell imaging.
 Since His-tag is the most widespread affinity tag  used for protein purification, anti-His-tag iBodies is eminently  suitable for a wide scientific community, as anti-His-tag antibodies are  known to work quite poorly. iBodies developed against particular  proteins of interest might become an alternative to antibodies used  either in scientific research, or diagnostics and therapy.
 The  system is highly flexible and modular since in theory, virtually any  compound can be added to satisfy user's needs and requirements.  Importantly, to create new specific iBodies binding a particular  protein, a simple replacement of the inhibitor is sufficient. Moreover,  iBodies are all?rounders; one type of iBodies can be used in a number of  biochemical applications. Finally, iBodies enable to target related  group of proteins, such as paralogs, orthologs or families of enzymes,  according to the specificity of the used targeting ligand.
 To  conclude, the iBodies platform can be used to produce inexpensive,  stable and non?animal-based antibody substitutes directed virtually  toward any protein of interest with a known ligand.
Additional file 2 of Targeting focal adhesion kinase boosts immune response in KRAS/LKB1 co-mutated lung adenocarcinoma via remodeling the tumor microenvironment
Creators: name: Qiao, Meng
name: Zhou, Fei
name: Liu, Xinyu
name: Jiang, Tao
name: Wang, Haowei
name: Li, Xuefei
name: Zhao, Chao
name: Cheng, Lei
name: Chen, Xiaoxia
name: Ren, Shengxiang
name: Wang, Zaiqi
name: Zhou, Caicun
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2: Table S2. Names of collagen formation-related genes and top 20 collagen-related genes.
Antiproliferative And Antimetastatic Effects Of Miconazole On Human Non-Small Lung And Colon Cancer Cells
Creators: name: Eng?R, Selin
name: Tilki, Elif Kaya
name: Mustafa G??L? ?Zarda
name: Miri? Dikmen
name: Cant?Rk, Zerrin
Publisher: name: Zenodo
Year: 2016
Subjects: Miconazole
A549
Caco2

description: Backgrounds: The rapid development of medicine and pharmacology allows to create effective anticancer drugs. Apparently, there is a need for new therapeutic strategies focusing on inhibition of cancer cell proliferation. The discovery of the antifungal activity of azole compounds represented an important therapeutic advance. Miconazole used as a common treatment for superficial fungal infection. Besides the antifungal activity of miconazole several studies were identified some additional therapeutic effects such as anticancer activity.
Purpose: In this study, was to determine the antiproliferative, anti-migration and anti-invasion effects of miconazole on A549 human non-small lung cancer and Caco2 colon cancer cells.
Methods: To evaluate anticancer potential of the miconazole, the methods measuring various antiproliferative endpoints were employed including MTT assay, real time monitoring of cell proliferation, anti-invasion and anti-migration with Real time cell analyzer system. The cytotoxic effects of different concentrations were investigated on both cells and then IC50 values were calculated.
Results: Cell proliferation assay was performed with miconazole IC50 concentrations (28.5 ?g/mL for Caco2 and 31.5 ?g/mL for A549 cells). Subsequently, antimetastatic efect were conducted on cancer cell lines with the IC50 concentrations. Miconazole was effected on cell death and antimetastatic activities of both cancer cells. Furthermore miconazole was significantly inhibited invasion and migration activities of A549 compared to Caco2 cells.
Conclusions: This study should be supported by molecular cell mechanisms of antitumor effects of miconazole for lung and colon cancer therapies.
sj-pdf-1-sjp-10.1177_1403494820987468 – Supplemental material for Paternal prescription medication before conception: A retrospective cohort study of all births in Denmark 1997–2017
Creators: name: M.J. Wensink
name: S. Rizzi
name: T.K. Jensen
name: N.E. Skakkebaek
name: Y. Lu
name: R. Lindahl-Jacobsen
name: M.L. Eisenberg
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-sjp-10.1177_1403494820987468 for Paternal prescription medication before conception: A retrospective cohort study of all births in Denmark 1997–2017 by M.J. Wensink, S. Rizzi, T.K. Jensen, N.E. Skakkebaek, Y. Lu, R. Lindahl-Jacobsen and M.L. Eisenberg in Scandinavian Journal of Public Health
Transmissions in gapped graphene exposed to tilting and oscillating barriers
Creators: name: Mekkaoui, Miloud
name: Jellal, Ahmed
name: Mouhafid, Abderrahim El
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We investigate the transmissions of fermions through gapped graphene structures by employing a combination of double barrier tilting and a time-oscillating potential. The latter introduces additional sidebands into the transmission probability, which manifest at energy levels determined by the frequency and incident energy. These sidebands arise from the absorption or emission of photons generated by the oscillating potential. We demonstrate that the tilting and positioning of the scattering events within the barriers play a crucial role in determining the peak of tunneling resistance. In particular, the presence of a mid-barrier-embedded scatter leads to a transition from a peak to a cusp when the incident energy reaches the Dirac point within a barrier. Additionally, we illustrate that introducing a time-varying potential results in transmissions dispersing across both the central band and the sidebands.
description: 10 pages, 7 figures. Clarification added
sj-pdf-1-dvr-10.1177_1479164121989281 – for Age-associated decline of monocyte insulin sensitivity in diabetic and healthy individuals
Creators: name: Nakamura, Suguru
name: Mori, Kentaro
name: Okuma, Hideyuki
name: Sekine, Tetsuo
name: Miyazaki, Asako
name: Kyoichiro Tsuchiya
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Cardiology
subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: FOS: Health sciences
subject: 110323 Surgery

description: sj-pdf-1-dvr-10.1177_1479164121989281 for Age-associated decline of monocyte insulin sensitivity in diabetic and healthy individuals by Suguru Nakamura, Kentaro Mori, Hideyuki Okuma, Tetsuo Sekine, Asako Miyazaki and Kyoichiro Tsuchiya in Diabetes & Vascular Disease Research
E05640: Venantius Fortunatus, in a poem On the saints of Agaune, writes of relics of *Maurice and the Theban Legion (martyrs of Agaunum, S00339), and invokes their support. Poem 2.14, written in Latin, probably at Saint-Maurice-d'Agaune (eastern Gaul), 565/567.
Creators: name: Kwojtalik
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: Venantius Fortunatus, Poems 2.14 (De sanctis Agaunensibus, 'On the saints of Agaune'), 19-20, 29-30

Extracts from a poem praising the martyrdom in the Alps of the Theban Legion.

Ecce, triumphantum ductor fortissime, tecum
 quattuor hic procerum pignora sancta iacent 20
...

Fortunatus enim per fulgida dona tonantis,
 ne tenebris crucier, quaeso feratis opem. 30

'See [Maurice], most valiant leader of the triumphant soldier, here lie with you the holy relics of four noble men ... I, Fortunatus, now beg by the glorious bounty of God that you grant me your aid that I may not be tormented by darkness.'

Text: Leo 1881, 42-43. Translation: Roberts 2017, 105, lightly modified.
Investigation Of Antiproliferative And Apoptotic Effects Of Tioconazole On Caco-2 Cell Line
Creators: name: Mustafa ?Zarda
name: Miri? Dikmen
name: Eng?R, Selin
name: Tilki, Elif Kaya
name: Cant?Rk, Zerrin
Publisher: name: Zenodo
Year: 2016
Subjects: Tioconazole
Caco-2
Antiproliferation

description: Tioconazole is an antifungal agent which works by weakening the cell membrane of the fungus. Treatment of tioconazole results with the death of the fungus. The development of cancer resistance to standard drug therapy and toxic effects are the main issues confronted in chemotherapy of various cancer types. The aim of our study is determining antiproliferative effect of tioconazole which is known as antifungal agent. In this study, antiproliferative and cytotoxic effects of different concentrations (400, 200, 100, 50, 25, 12.5, 6.25, 3.125, 1.56 and 0.78 ?g/mL) of tioconazole investigated on Caco2 human colon cancer cells. 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide MTT assay and flow cytometry were performed on mitochondrial activity levels to observe cytotoxic and apoptotic effects on Caco2 cells for 24 hours. As a result the required concentration to inhibit the cell growth by 50% (IC50) on Caco2 cells for tioconazole was 55.54?g/mL after incubation for 24h. Apoptotic effects of tioconazole is evaluated via flow cytometry with Annexin V and PI. Tioconazole showed significant cytotoxic and apoptotic effect on Caco-2 cell line. After further studies, in this regard, tioconazole which known as an antifungal agent may be a new candidate for colon cancer therapy.
Homogeneous isosceles-free spaces
Creators: name: Bargetz, Christian
name: Bartoš, Adam
name: Kubiś, Wiesław
name: Luggin, Franz
Publisher: name: arXiv
Year: 2023
Subjects: subject: Logic (math.LO)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 03C50, 20B25, 51F99, 54E35, 05C15, 05E18

description: We study homogeneity aspects of metric spaces in which all triples of distinct points admit pairwise different distances; such spaces are called isosceles-free. In particular, we characterize all homogeneous isosceles-free spaces up to isometry as vector spaces over the two-element field, endowed with an injective norm. Using isosceles-free decompositions, we provide bounds on the maximal number of distances in arbitrary homogeneous finite metric spaces.
description: 36 pages
E05641: Venantius Fortunatus, in a poem On saint *Medard (bishop of Noyon buried at Soissons, ob. 557/558, S00168) recounts miracles during his lifetime, and after his death at his tomb in Soissons (north-east Gaul), where King Sigibert completed the construction of his church. Poem 2.16, written in Latin in Gaul, 565/575.
Creators: name: Kwojtalik
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: Venantius Fortunatus, Poems 2.16 (De Sancto Medardo, 'On Saint Medard', BHL 5863)

Summary:

Medard performed several miracles during his lifetime, especially with the blind, whom he healed with his touch (lines 25-30). He stopped a thief who was trying to steal grapes (lines 31-48); and exposed another thief who tried to steal a cattle-bell (lines 49-64).

After his body was laid on a bier, a blind man was cured (lines 65-76). Another man came to his church in Soissons, where he was miraculously freed from strong handcuffs and fetters (lines 77-92). A second prisoner, in wooden shackles, was similarly freed after he arrived at the church (lines 93-104). An old woman with knotted fingers was healed at Medard's tomb (lines 105-122). Medard also cured a young girl (now dedicated to virginity), and a baby girl, with similar deformities of the hand (lines 123-138). Another blind man was cured, after he had been advised in his sleep by Medard to come to his church, and had spent three days lying in front of his tomb (lines 139-156).

King Sigibert built this church, for whom Fortunatus invokes the protection of the saint (lines 161-164).

Finally, Fortunatus himself seeks Medard's aid (lines 165-166).

Text: Leo 1881, 44-48.
Summary Katarzyna Wojtalik.
Top 100 cited research on COVID-19 vaccines: A bibliometric analysis and evidence mapping
Creators: name: Yu, Liping
name: Xu, Caihua
name: Zhang, Mingyue
name: Zhou, Yongjia
name: Hu, Zhiruo
name: Li, Lin
name: Li, Yiyi
name: Tian, Jinhui
name: Xu, Mingli
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: The outbreak of the COVID-19 has seriously affected the whole society, and vaccines were the most effective means to contain the epidemic. This paper aims to determine the top 100 articles cited most frequently in COVID-19 vaccines and to analyze the research status and hot spots in this field through bibliometrics, to provide a reference for future research. We conducted a comprehensive search of the Web of Science Core Collection database on November 29, 2023, and identified the top 100 articles by ranking them from highest to lowest citation frequency. In addition, we analyzed the year of publication, citation, author, country, institution, journal, and keywords with Microsoft Excel 2019 and VOSviewer 1.6.18. Research focused on vaccine immunogenicity and safety, vaccine hesitancy, and vaccination intention.
Additional file 3 of Targeting focal adhesion kinase boosts immune response in KRAS/LKB1 co-mutated lung adenocarcinoma via remodeling the tumor microenvironment
Creators: name: Qiao, Meng
name: Zhou, Fei
name: Liu, Xinyu
name: Jiang, Tao
name: Wang, Haowei
name: Li, Xuefei
name: Zhao, Chao
name: Cheng, Lei
name: Chen, Xiaoxia
name: Ren, Shengxiang
name: Wang, Zaiqi
name: Zhou, Caicun
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 3: Figure S1. The preparation and confirmation of cell lines in the study. A The schematic illustration for preparation of KL cell lines. B The confirmation of two cell lines by western blot analysis.
Systematic Improvements in Transmon Qubit Coherence Enabled by Niobium Surface Encapsulation
Creators: name: Bal, Mustafa
name: Murthy, Akshay A.
name: Zhu, Shaojiang
name: Crisa, Francesco
name: You, Xinyuan
name: Huang, Ziwen
name: Roy, Tanay
name: Lee, Jaeyel
name: van Zanten, David
name: Pilipenko, Roman
name: Nekrashevich, Ivan
name: Lunin, Andrei
name: Bafia, Daniel
name: Krasnikova, Yulia
name: Kopas, Cameron J.
name: Lachman, Ella O.
name: Miller, Duncan
name: Mutus, Josh Y.
name: Reagor, Matthew J.
name: Cansizoglu, Hilal
name: Marshall, Jayss
name: Pappas, David P.
name: Vu, Kim
name: Yadavalli, Kameshwar
name: Oh, Jin-Su
name: Zhou, Lin
name: Kramer, Matthew J.
name: Lecocq, Florent Q.
name: Goronzy, Dominic P.
name: Torres-Castanedo, Carlos G.
name: Pritchard, Graham
name: Dravid, Vinayak P.
name: Rondinelli, James M.
name: Bedzyk, Michael J.
name: Hersam, Mark C.
name: Zasadzinski, John
name: Koch, Jens
name: Sauls, James A.
name: Romanenko, Alexander
name: Grassellino, Anna
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We present a novel transmon qubit fabrication technique that yields systematic improvements in T$_1$ relaxation times. We fabricate devices using an encapsulation strategy that involves passivating the surface of niobium and thereby preventing the formation of its lossy surface oxide. By maintaining the same superconducting metal and only varying the surface structure, this comparative investigation examining different capping materials, such as tantalum, aluminum, titanium nitride, and gold, and film substrates across different qubit foundries definitively demonstrates the detrimental impact that niobium oxides have on the coherence times of superconducting qubits, compared to native oxides of tantalum, aluminum or titanium nitride. Our surface-encapsulated niobium qubit devices exhibit T$_1$ relaxation times 2 to 5 times longer than baseline niobium qubit devices with native niobium oxides. When capping niobium with tantalum, we obtain median qubit lifetimes above 300 microseconds, with maximum values up to 600 microseconds, that represent the highest lifetimes to date for superconducting qubits prepared on both sapphire and silicon. Our comparative structural and chemical analysis suggests why amorphous niobium oxides may induce higher losses compared to other amorphous oxides. These results are in line with high-accuracy measurements of the niobium oxide loss tangent obtained with ultra-high Q superconducting radiofrequency (SRF) cavities. This new surface encapsulation strategy enables even further reduction of dielectric losses via passivation with ambient-stable materials, while preserving fabrication and scalable manufacturability thanks to the compatibility with silicon processes.
Supplemental Material, sj-pdf-1-jcr-10.1177_0022002720987285 - Private Eyes in the Sky: Emerging Technology and the Political Consequences of Eroding Government Secrecy
Creators: name: Lin-Greenberg, Erik
name: Milonopoulos, Theo
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 220104 Human Rights and Justice Issues
subject: FOS: Philosophy, ethics and religion
subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental Material, sj-pdf-1-jcr-10.1177_0022002720987285 for Private Eyes in the Sky: Emerging Technology and the Political Consequences of Eroding Government Secrecy by Erik Lin-Greenberg and Theo Milonopoulos in Journal of Conflict Resolution
Additional file 1 of A reliability analysis: human trafficking curriculum assessment tool (HT-CAT) for health care provider human trafficking trainings
Creators: name: Stoklosa, Hanni
name: Wang, Xichen
name: Meng, Boci
name: Rydberg, Jason
name: Adewusi, Adebimpe
name: Barney, Madison Murphy
name: Glassman, Kendra
name: Napolitano, Kara
name: Wald, Claudia
name: Bachrach, Lela
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health

description: Supplementary Material 1
E05642: Venantius Fortunatus, in a prose letter to Eufronius, bishop of Tours, included in Fortunatus' collection of poems, asks Eufronius to pray for him at the tomb of *Martin (ascetic and bishop of Tours, ob. 397, S00050) in Tours (north-west Gaul), in 565/573. Poem 3.2, written in Latin in Gaul, 565/573.
Creators: name: Kwojtalik
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: Venantius Fortunatus, Poems 3.2 (Ad eundem = Ad Eufronium episcopum Turonensem, 'To the same person' [Eufronius, bishop of Tours]), § 5

Extract:

Quapropter dominationi et sanctitati vestrae peculiariter me commendans rogo et obtestor (sic ille domnus meus Martinus sua intercessione obtineat, ut cum ipso iuxta merita vestra in luce perpetua vos conlocet divina misericordia), ut pro me humili filio et servo vestro ad eius beatum sepulcrum orare digneris et pro peccatorum meorum remissione pius intercessor accedas.

'Therefore I commend myself in particular to your [Eufronius'] lordship and sanctity and ask and beseech - so may my lord Martin secure by his intercession that the divine mercy establish you with him according to your merits in light everlasting - that you see fit to pray for your humble son and servant at his blessed tomb and that as merciful intercessor you approach him for the remission of my sins.'

Text: Leo 1881, 50. Translation: Roberts 2017, 127 and 129.
Additional file 1 of Impaired sleep quality mediates the relationship between internet gaming disorder and conduct problems among adolescents: a three-wave longitudinal study
Creators: name: Peng, Pu
name: Jin, Jieyin
name: Chen, Zhangming
name: Ren, Silan
name: He, Ying
name: Li, Jinguang
name: Liao, Aijun
name: Zhao, Linlin
name: Shao, Xu
name: Chen, Shanshan
name: He, Ruini
name: Liang, Yudiao
name: Tan, Youguo
name: Chen, Xiaogang
name: Tang, Jinsong
name: Liao, Yanhui
Publisher: name: figshare
Year: 2025
Subjects: Cell Biology
Neuroscience
Chemical Sciences not elsewhere classified
Science Policy
Mental Health

description: Supplementary Material 1
Particle acceleration in solar flares with imaging-spectroscopy in soft X-rays
Creators: name: Oka, Mitsuo
name: Caspi, Amir
name: Chen, Bin
name: Cheung, Mark
name: Drake, James
name: Gary, Dale
name: Glesener, Lindsay
name: Guo, Fan
name: Ji, Hantao
name: Li, Xiaocan
name: Nakamura, Takuma
name: Narukage, Noriyuki
name: Reeves, Katharine
name: Saint-Hilaire, Pascal
name: Sakao, Taro
name: Shen, Chengcai
name: Winebarger, Amy
name: Woods, Tom
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Plasma Physics (physics.plasm-ph)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Particles are accelerated to very high, non-thermal energies during explosive energy-release phenomena in space, solar, and astrophysical plasma environments. In the case of solar flares, it has been established that magnetic reconnection plays an important role for releasing the magnetic energy, but it remains unclear if or how magnetic reconnection can further explain particle acceleration during flares. Here we argue that the key issue is the lack of understanding of the precise context of particle acceleration but it can be overcome, in the near future, by performing imaging-spectroscopy in soft X-rays (SXRs). Such observations should be complemented by observations in other wavelengths such as extreme-ultraviolets (EUVs), microwaves, hard X-rays (HXRs), and gamma-rays. Also, numerical simulations will be crucial for further narrowing down the particle acceleration mechanism in the context revealed by the observations. Of all these efforts, imaging-spectroscopy in SXRs, if successfully applied to large limb flares, will be a milestone in our challenge of understanding electron acceleration in solar flares and beyond, i.e. the Plasma Universe.
description: White paper submitted to the Decadal Survey for Solar and Space Physics (Heliophysics) 2024-2033; 10 pages, 2 figures