cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Toxicology study of a tissue anchoring paclitaxel prodrug
Creators: name: Oh, Annie
name: Neumann-Rivera, Isabel B.
name: Pierce, Joshua G.
name: Haynes, Hannah R.
name: Meritet, Danielle M.
name: Brudno, Yevgeny
name: Nie, Minhua
name: Henderson, Nichol M.
name: Stephens, Jazz Q.
name: Chinthapatla, Rukesh
Publisher: name: Springer Nature
Year: 2024

description:
Background Local drug presentation made possible by drug-eluting depots provides benefits for a vast array of diseases, including cancer, microbial infection, and wound healing. Drug-eluting depots provide sustained drug release of therapeutics directly at disease sites with tunable kinetics, remove the need for drugs to access disease sites from circulation, and reduce the side effects associated with systemic therapy. Recently, we introduced an entirely novel approach to local drug presentation named Tissue-Reactive Anchoring Pharmaceuticals (TRAPs). TRAPs enables local drug presentation without any material carriers, capitalizing on innate tissue structures to anchor drugs at the site of administration. Methods In this report, we comprehensively evaluate the local and systemic toxicological profile of a paclitaxel version of TRAPs in mice by clinical observations, body weight monitoring, histopathological evaluations of injection sites and major organs, as well as blood and urine analyses. Results We find that intradermal administration of TRAP-paclitaxel does not induce substantial toxic effects. Localized inflammatory responses were observed at the injection sites and secondary minimal, non-specific inflammation was observed in the liver. All other organs displayed unremarkable histological findings. Conclusions These findings support the potential of TRAP-paclitaxel as a promising candidate for localized cancer treatment, offering high-concentration drug delivery while mitigating scarring and adverse side effects.
MOESM1 of Isolation and characterization of glycolipid biosurfactant produced by a Pseudomonas otitidis strain isolated from Chirimiri coal mines, India
Creators: name: Singh, Pallavi
name: Bhupendra Tiwary
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 1. Figure S1. Screening for BS production (A) Drop collapse method (B) Modified drop collapse method (C) Emulsification assay.
Ophiothamnidae O'Hara, Stohr, Hugall, Thuy & Martynov 2018
Creators: name: Stöhr, Sabine
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Ophiuroidea
Amphilepidida
Ophiothamnidae

description: Ophiothamnidae
- oral GP unknown
- adGP bar-like with bulbous end, condylar process
- abGP thin, flat, blade-like
- RS with low condyle, no groove or ledge
description: Published as part of Stöhr, Sabine, 2024, Taxonomic analysis of the genital plates and associated structures in Ophiuroidea (Echinodermata), pp. 1-98 in European Journal of Taxonomy 933 on page 75, DOI: 10.5852/ejt.2024.933.2525, http://zenodo.org/record/11198874
Additional file 1: of Characteristics of well-propagated teaching innovations in undergraduate STEM
Creators: name: Khatri, Raina
name: Henderson, Charles
name: Cole, Renee
name: Froyd, Jeffrey
name: Friedrichsen, Debra
name: Stanford, Courtney
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Full set of Well-Propagated Strategies and Materials. (DOCX 34 kb)
Relapse Free Survival Progressive Shortens in a Subset of Black patients with Immune TTP Treated in the Rituximab Era
Creators: name: Gangaraju, Radhika
name: Masias, Camila
name: Evans, Michael D.
name: Chaturvedi, Shruti
name: Woods, Ryan
name: Park, Yara A
name: Liles, Darla K
name: Johnson, Andrew
name: Kreuziger, Lisa Baumann
name: de Ridder, Gustaaf
name: Akwaa, Frank
name: Sadler, J. Evan
name: McCrae, Keith R
name: Kocher, Nicole K.
name: Brown, Jenna
name: Go, Ronald S.
name: Raval, Jay S
name: Mazepa, Marshall
name: Antun, Ana G.
name: Gibson, Briana
name: Clover, Todd
name: Metjian, Ara
name: Lim, Ming Y.
name: Fatola, Ayotola
name: Zheng, X. Long
name: Farland, Andrew M.
name: Cataland, Spero R.
name: Kasthuri, Raj S.
name: USTMA Consortium
name: Davis, Elizabeth
name: Sridharan, Meera
name: Eubanks, Susan
name: Upreti, Harsh Vardhan
Publisher: name: American Society of Hematology
Year: 2024

description:
Immune thrombotic thrombocytopenic purpura (iTTP) is a chronically relapsing disorder caused by autoantibody mediated deficiency of ADAMTS13. Rituximab is frequently administered to prevent relapses, but whether the durability of rituximab is maintained with subsequent treatment courses has not been studied. Using the United States Thrombotic Microangiopathy Consortium (USTMA) retrospective iTTP registry, we evaluated clinical relapse free survival (RFS) with subsequent courses of rituximab treatment in multiply relapsing patients. Separately, we evaluated overall RFS (composite of time to clinical relapse, ADAMTS13 relapse, or preemptive rituximab) in a prospective iTTP cohort from the Johns Hopkins University and the University of Minnesota. In the USTMA registry, median clinical RFS was shorter after the 2nd or subsequent rituximab-treated episode compared to the first (2.1 vs 6.0 years, P = 0.04). White patients' clinical relapse risk after the second and subsequent rituximab courses was not significantly different compared to the first [HR=1.86 (95% CI 0.22-15.80), P=0.57], while for Black patients, clinical relapse risk was significantly higher after the second or subsequent courses [HR=2.82 (95% CI 1.52-5.24), P=0.001]. In the prospective cohort, overall RFS progressively shortened after each episode of rituximab treatment with the first episode having the longest RFS (2.8 years IQR 2.0-6.0) and this loss of response durability was most pronounced in Black patients. The durability of rituximab's effect declines with subsequent treatments, which is more pronounced in Black patients who may benefit from closer monitoring and alternative immunomodulatory approaches such as maintenance rituximab and consideration of other agents.
title: ความอดทนสู่ความสามัคคี: วิถีมุสลิมในเอกภาพบนความหลากหลาย กับการเผชิญกับการแพร่ระบาด COVID-19
Creators: name: ซารีฮาน ขวัญคาวิน
Publisher: name: สถาบันเอเชียศึกษา
publisherIdentifierScheme: ROR
Year: 2024
Subjects: โควิต 19
ภาวะเปราะบาง
วิถีมุสลิม

description: เอเชียปริทัศน์, 45, 1, 32-69
MOESM12 of Leveraging 3D chemical similarity, target and phenotypic data in the identification of drug-protein and drug-adverse effect associations
Creators: name: Vilar, Santiago
name: Hripcsak, George
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 12: Figure S6. RMSDs between co-crystallized drugs and theoretical conformations determined through MCMM.
Información es poder (information is power): menopause knowledge, attitudes, and experiences in midlife Hispanic women and Latinas
Creators: name: Cazales, Andrea
name: Cortés, Yamnia I.
name: Trocel, Lorena
name: Duran, Mayra
name: Mărginean, Valentina
Publisher: name: Springer Nature
Year: 2024

description:
Background Latinas constitute nearly 20% of midlife women in the United States (U.S.), but remain underrepresented in menopause research. Many midlife Latinas are disadvantaged by limited English proficiency, less formal education, living below the federal poverty level, lack of health insurance, and social isolation and discrimination — factors that negatively affect menopause-related symptoms and health outcomes. This study aimed to understand knowledge, attitudes, and experiences of the menopause transition among midlife Latinas. Methods We conducted a qualitative descriptive study using five focus groups with 29 Hispanic/Latina midlife women. An emergent content analysis was performed by four bilingual coders. Data on socio-demographics, menopausal symptoms, menopause knowledge, and attitudes toward menopause and hormone therapy were collected over the phone. Descriptive statistics were performed to characterize study participants. Results Participants were aged 50.3 ± 6.3 years, 45% postmenopausal, 79% viewed menopause positively, and 55% reported having “little knowledge” about menopause. Seven themes emerged: 1) menopause is a stage of life (una etapa de vida); 2) not wanting to become an old lady (no quererme hacer viejita); 3) in our culture, we do not ask [about menopause]; 4) family dynamics; 5) each body is different (todo cuerpo es diferente); 6) menopause self-management and treatment options; 7) information is power (información es poder). Conclusions Although Latinas reported having a positive view of menopause, we found a need for culturally-tailored comprehensive menopause education. The importance of involving family members in menopause education was also revealed. Our next steps are to determine the best menopause messaging strategies and educational formats for midlife Latinas.
Ophiopsilina Matsumoto 1915
Creators: name: Stöhr, Sabine
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Ophiuroidea
Amphilepidida

description: Ophiopsilina
- distal opening in inner madreporite
description: Published as part of Stöhr, Sabine, 2024, Taxonomic analysis of the genital plates and associated structures in Ophiuroidea (Echinodermata), pp. 1-98 in European Journal of Taxonomy 933 on page 75, DOI: 10.5852/ejt.2024.933.2525, http://zenodo.org/record/11198874
Targeting Nav1.7 and Nav1.8 with a PIKfyve inhibitor to Reverse inflammatory and neuropathic pain
Creators: name: Khanna, Rajesh
name: Min, Sophia M.
name: Rodríguez-Palma, Erick J.
name: Axtman, Alison D.
name: Gomez, Kimberly
name: Calderon-Rivera, Aida
name: Loya-Lopez, Santiago
Publisher: name: Elsevier
Year: 2024

description:
PIKfyve (1-phosphatidylinositol 3-phosphate 5-kinase), a lipid kinase, plays an important role in generating phosphatidylinositol (3,5)-bisphosphate (PI(3,5)P2). SGC-PIKFYVE-1, a potent and selective inhibitor of PIKfyve, has been used as a chemical probe to explore pathways dependent on PIKfyve activity. Based on reported changes in membrane dynamics and ion transport in response to PIKfyve inhibition, we hypothesized that pharmacological inhibition of PIKfyve could modulate pain. Acute treatment with SGC-PIKFYVE-1 (10 µM) inhibited voltage-gated sodium currents through the inhibition of Nav1.7 and Nav1.8 channels, without affecting voltage-gated calcium or potassium currents in sensory neurons. Additionally, systemic administration of SGC-PIKFYVE-1 (30 mg/kg) alleviated mechanical and cold sensitivity induced by neuropathic or inflammatory pain in both male and female mice, without causing motor impairments. Although other functions of PIKfyve are well characterized, its role in inhibiting chronic pain has not been fully elucidated. Our study provides proof-of-concept for this alternative approach to pain management. Collectively, these results highlight the inhibitory effects of PIKfyve as a promising avenue for further exploration in chronic pain treatment.
MOESM12 of Leveraging 3D chemical similarity, target and phenotypic data in the identification of drug-protein and drug-adverse effect associations
Creators: name: Vilar, Santiago
name: Hripcsak, George
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 12: Figure S6. RMSDs between co-crystallized drugs and theoretical conformations determined through MCMM.
An innovation bootcamp model for developing youth-led HIV self-testing delivery strategies in Nigeria: post-designathon capacity building
Creators: name: Oladele, David
name: Obiezu-Umeh, Chisom
name: Musa, Adesola Z.
name: Idigbe, Ifeoma
name: BeLue, Rhonda
name: Tahlil, Kadija M.
name: Xian, Hong
name: Ezechi, Oliver
name: Olusanya, Olufunto
name: Gbaja-Biamila, Titilola
name: Tucker, Joseph D.
name: Nwaozuru, Ucheoma
name: Airhihenbuwa, Collins
name: Ojo, Temitope
name: Iwelunmor, Juliet
name: Conserve, Donaldson
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description:
Many designathons, hackathons, and similar participatory events suffer from minimal training and support after the events. Responding to this need, we organized a health innovation bootcamp: an intensive, team-based apprenticeship training with research and entrepreneurial rigor among young people in Nigeria to develop HIV self-testing (HIVST) delivery strategies for Nigerian youth. The purpose of this paper was to describe an innovation bootcamp that aimed to develop HIVST delivery strategies for Nigerian youth. The four-week, in-person innovation bootcamp, informed by youth participatory action research and comprised a series of workshops, took place in Lagos, Nigeria. The goal was to build research and entrepreneurial capacities among young people to develop and implement HIVST strategies. A qualitative content analysis informed by an adapted World Health Organization’s HIVST delivery framework explored key elements of the proposed HIVST service delivery strategies developed at the bootcamp. Twenty participants, aged 18–24 years, from five teams completed the innovation bootcamp. The five teams developed HIV service delivery strategies that included an element of repacking HIVST kits to make them more appealing to young people. Other strategies that emerged included leveraging community engagement platforms (e.g., vocational skills training and youth community events) to promote HIVST, and the use of reward-referral system to encourage HIVST uptake among young people. All strategies included ways to ensure privacy protection for recipients of the HIVST delivery package. This study demonstrated the feasibility and acceptability of the health innovation bootcamp model to create HIVST designed for and led by young people. This suggests a way to build capacity after participatory events to sustain youth-led research, which could have implications for post-designathon training.
Toritrombicula kirhocephalus Goff 1982
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Trombiculidae
Toritrombicula
Toritrombicula kirhocephalus

description: Toritrombicula kirhocephalus Goff, 1982f:
AUS
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 182, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510
Differences in hepatitis C virus (HCV) testing and treatment by opioid, stimulant, and polysubstance use among people who use drugs in rural U.S. communities
Creators: name: Brook, Daniel
name: Pho, Mai T.
name: Tsui, Judith I.
name: Mixson, L. Sarah
name: Young, April M.
name: Korthuis, P. Todd
name: Westergaard, Ryan P.
name: Jenkins, Wiley
name: Friedmann, Peter D.
name: Feinberg, Judith
name: Smith, Gordon
name: Lowe, Kelsa
name: Kline, David
name: Lancaster, Kathryn E.
name: Miller, William C.
name: Go, Vivian F.
name: Rice, Dylan R.
name: Estadt, Angela T.
name: Hurt, Christopher B.
name: Cooper, Hannah
Publisher: name: Springer Nature
Year: 2024

description:
Background People who use drugs (PWUD) in rural communities increasingly use stimulants, such as methamphetamine and cocaine, with opioids. We examined differences in hepatitis C virus (HCV) testing and treatment history among rural PWUD with opioids, stimulants, and other substance use combinations. Methods PWUD were enrolled from ten rural U.S. communities from 2018 to 2020. Participants self-reporting a positive HCV result were asked about their HCV treatment history and drug use history. Drug use was categorized as opioids alone, stimulants alone, both, or other drug(s) within the past 30 days. Prevalence ratios (PR) were yielded using adjusted multivariable log-binomial regression with generalized linear mixed models. Results Of the 2,705 PWUD, most reported both opioid and stimulant use (74%); while stimulant-only (12%), opioid-only (11%), and other drug use (2%) were less common. Most (76%) reported receiving HCV testing. Compared to other drug use, those who reported opioid use alone had a lower prevalence of HCV testing (aPR = 0.80; 95% CI: 0.63, 1.02). Among participants (n = 944) who self-reported an HCV diagnosis in their lifetime, 111 (12%) ever took anti-HCV medication; those who used both opioids and stimulants were less likely to have taken anti-HCV medication compared with other drug(s) (aPR = 0.41; 95% CI: 0.19, 0.91). Conclusions In this pre-COVID study of U.S. rural PWUD, those who reported opioid use alone had a lower prevalence of reported HCV testing. Those diagnosed with HCV and reported both opioid and stimulant use were less likely to report ever taking anti-HCV medication.
Ophiopsilidae Matsumoto 1915
Creators: name: Stöhr, Sabine
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Ophiuroidea
Amphilepidida
Ophiopsilidae

description: Ophiopsilidae
- oral GP elongated, narrow, thin
- adGP with single condyle and shallow groove
- abGP sabre-like, simple articular surface
description: Published as part of Stöhr, Sabine, 2024, Taxonomic analysis of the genital plates and associated structures in Ophiuroidea (Echinodermata), pp. 1-98 in European Journal of Taxonomy 933 on page 75, DOI: 10.5852/ejt.2024.933.2525, http://zenodo.org/record/11198874
Additional file 1: of Medical 3D printing for vascular interventions and surgical oncology: a primer for the 2016 radiological society of North America (RSNA) hands-on course in 3D printing
Creators: name: Chepelev, Leonid
name: Hodgdon, Taryn
name: Gupta, Ashish
name: Wang, Aili
name: Torres, Carlos
name: Satheesh Krishna
name: Akyuz, Ekin
name: Mitsouras, Dimitrios
name: Sheikh, Adnan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Marine Biology
subject: Cancer
subject: Mental Health

description: Printing a 3D Model with Polyjet Studio. (DOCX 1049 kb)
Toritrombicula nissani
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Trombiculidae
Toritrombicula
Toritrombicula nissani

description: Toritrombicula nissani (Dumbleton, 1947):
AUS
Trombicula nissani Dumbleton, 1947
Trombicula (Trombicula) nissani, Wharton & Fuller 1952
Trombicula (Vorcana) nissani, Audy 1956c
Toritrombicula (Toritrombicula) nissani, Vercammen-Grandjean 1965d
Toritrombicula nissani, Nadchatram 1967b
Syn.: Trombicula (Leptotrombidium) myzantha Womersley, 1952
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 182, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510
Development of a remote implementation support strategy to enhance integration of depression treatment into primary care settings in rural India
Creators: name: Vorapanya, Vorapat
name: Bondre, Ameya
name: Tugnawat, Deepak
name: Naslund, John A.
name: Bhan, Anant
name: Patel, Vikram
name: Ramaswamy, Rohit
name: Haney, Juliana Restivo
name: Pedersen, Gloria A.
name: Choubey, Shivangi
name: Singh, Abhishek
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description:
Contextually responsive implementation support strategies are needed to enhance the integration of mental health services into primary health care. Technical assistance is widely used as a core “capacity building” strategy, primarily for increasing the motivation and capacity of individuals (e.g., frontline workers) to adopt evidence-based interventions in healthcare settings. This article documents the systematic design of a technical assistance strategy for supporting primary care staff (e.g., nurses) in integrating depression care, from screening to treatment, aligned with a non-communicable disease program across seven health facilities in the Sehore District of Madhya Pradesh, India. We conducted a mapping exercise of local health facilities with dedicated staff and a literature review to inform the development of the technical assistance strategy. Reporting guidelines guided the structure of the strategy protocol. The evidence-supported strategy, called Remote Coaching Support, is tailored to the local setting. It uses quality improvement methods like the Plan-Do-Act-Study cycle and training materials to help coaches deliver support remotely via video/phone-based calls and WhatsApp messaging with the overall goal of increasing uptake and fidelity of depression screening and referral among primary care staff in alignment with an existing non-communicable diseases program. The development of Remote Coaching Support involved iterative improvements through team meetings and practice-training feedback, though limitations exist due to a lack of systematic implementation standards, especially in this setting. This strategy will be tested in increasing scales to refine its application, with effectiveness and acceptability results to be evaluated in a randomized control trial.
Aonides Claparede 1864
Creators: name: Delgado-Blas, Victor Hugo
name: Salazar-Silva, Patricia
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Polychaeta
Spionida
Spionidae
Aonides

description: Genus Aonides Claparède, 1864
Aonides Claparède, 1864: 505.— Foster, 1971a: 66.
Type species: Nerine oxycephala Sars, 1862, designated by Foster, 1971a.
description: Published as part of Delgado-Blas, Victor Hugo & Salazar-Silva, Patricia, 2011, Taxonomic catalogue of the Spionidae (Annelida: Polychaeta) of the Grand Caribbean, pp. 39-66 in Zootaxa 2782 on page 41, DOI: 10.5281/zenodo.206833
Additional file 1: of MiR-182 promotes cancer invasion by linking RET oncogene activated NF-ÎşB to loss of the HES1/Notch1 regulatory circuit
Creators: name: Spitschak, Alf
name: Meier, Claudia
name: Kowtharapu, Bhavani
name: Engelmann, David
name: PĂźtzer, Brigitte
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Table S1. Primers used for amplification and Quantitative Real-Time PCR (qRT-PCR). (DOCX 18 kb)
Leveraging group model building to operationalize implementation strategies across implementation phases: an exemplar related to child maltreatment intervention selection
Creators: name: Lich, Kristen Hassmiller
name: Brown, C. Hendricks
name: Saldana, Lisa
name: Cruden, Gracelyn
name: Lanier, Paul
name: Frerichs, Leah
name: Powell, Byron J.
Publisher: name: Springer Nature
Year: 2024

description:
Background Implementation strategies can help support the adoption and implementation of health interventions that are appropriate for a local context and acceptable to decision makers and community members. Implementation strategies should be designed to handle the complexity of the multi-level, dynamic contexts in which interventions are implemented. Systems science theories and methods explicitly attend to complexity and can be valuable for specifying implementation strategies. Group Model Building (GMB) combines research partner engagement strategies with systems science to support researchers’ and partners’ learning about complex problems and to identify solutions through consensus. This paper specifies how GMB can operationalize implementation strategies — methods for supporting evidence implementation in real-world practice — and describes how GMB can aid in selecting and tailoring both health interventions and implementation strategies. A case study in child maltreatment prevention planning is provided to illustrate how GMB was used to specify the “actions” — strategy activities — for three implementation strategies (conduct local consensus discussions; build a coalition; model and simulate change) during the earliest implementation phases, with the goal of supporting intervention selection decisions. Examples are provided of generalizable research products that can be produced concurrently through GMB, in addition to contextually-driven implementation support. Methods Participants (n = 8) were engaged over four sessions using tailored GMB activities. Participants generated a qualitative system dynamics model that described their theory of change for how to prevent child maltreatment in their communities. This theory of change reflected a dynamic understanding of the interconnected determinants of child maltreatment. Results GMB was acceptable to participants and resulted in products that could be used for implementation planning (e.g., to model and simulate change) and future research. GMB fostered trust and idea sharing between participants. Conclusion GMB can facilitate learning about which outcomes are (or are not) impacted by interventions, which resources and approaches are required for quality implementation (e.g., implementation strategies), and tradeoffs in outcomes and resources between interventions. GMB also provides a structured, effective process to generate a shared implementation vision amongst participants. Lessons learned include methods for developing trust with and between participants, and the need for researchers to tailor GMB actions for participant and project needs.
Apoprionospio Foster 1969
Creators: name: Delgado-Blas, Victor Hugo
name: Salazar-Silva, Patricia
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Polychaeta
Spionida
Spionidae
Apoprionospio

description: Genus Apoprionospio Foster, 1969
Apoprionospio Foster, 1969: 383.— Foster, 1971a: 93.— Maciolek, 1985: 368 –369. Type species: Apoprionospio dayi Foster, 1969, by original designation.
description: Published as part of Delgado-Blas, Victor Hugo & Salazar-Silva, Patricia, 2011, Taxonomic catalogue of the Spionidae (Annelida: Polychaeta) of the Grand Caribbean, pp. 39-66 in Zootaxa 2782 on page 41, DOI: 10.5281/zenodo.206833
Additional file 1: of MiR-182 promotes cancer invasion by linking RET oncogene activated NF-ÎşB to loss of the HES1/Notch1 regulatory circuit
Creators: name: Spitschak, Alf
name: Meier, Claudia
name: Kowtharapu, Bhavani
name: Engelmann, David
name: PĂźtzer, Brigitte
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Table S1. Primers used for amplification and Quantitative Real-Time PCR (qRT-PCR). (DOCX 18 kb)
Efficacy and Safety of Anthocyanin-Rich Extract in Patients with Ulcerative Colitis: A Randomized Controlled Trial
Creators: name: Burk, Sabine
name: Rogler, Gerhard
name: Schreiner, Philipp
name: Leventhal, Gabriel E.
name: Nielsen, Ole Haagen
name: Juillerat, Pascal
name: Hruz, Petr
name: Seibold, Frank
name: Doulberis, Michael
name: Schoepfer, Alain
name: Herfarth, Hans
name: Krieger-Grübel, Claudia
name: Brand, Stephan
name: Misselwitz, Benjamin
name: Biedermann, Luc
name: Leu, Kristin
name: The, Frans Olivier
name: Scharl, Sylvie
Publisher: name: MDPI
Year: 2024

description:
Background: Bilberries are effective in inducing clinical, endoscopic, and biochemical improvement in ulcerative colitis (UC) patients. The aim of this study was to investigate the efficacy of anthocyanin-rich extract (ACRE), the bioactive ingredient of bilberries, in a controlled clinical trial in moderate-to-severe UC. Methods: A multi-center, randomized, placebo-controlled, double-blind study with a parallel group was conducted. Initially, the study was planned for 100 patients; nevertheless, it prematurely ended due to COVID-19. Patients had moderate-to-severe active UC at screening (a Mayo score of 6–12, an endoscopic sub-score ≥ 2) and were randomized at baseline. The primary endpoint was a clinical response (week 8, a total Mayo score reduction ≥ 3 points). Fecal calprotectin (FC) and a centrally read endoscopic response were among the secondary endpoints. Results: Out of 48 patients (6 Swiss centers), 34 were randomized. Eighteen ACRE and eight placebo patients could be analyzed (per protocol set). Half (9/18) of ACRE patients and 3/8 of placebo patients responded clinically (p = 0.278). An improvement in the Mayo score was observed in the ACRE arm (77.8% vs. 62.5% placebo). FC dropped from 1049 ± 1139 to 557 ± 756 μg/g for ACRE but not for the placebo group (947 ± 1039 to 1040 ± 1179; p = 0.035). Serious adverse events were rare. Conclusions: ACRE treatment did not yield significant superiority to the placebo. Furthermore, the placebo response was unusually high. Moreover, there was a significant calprotectin decrease at the end of treatment, indicative of ACRE efficacy in UC.
Additional file 2: of Medical 3D printing for vascular interventions and surgical oncology: a primer for the 2016 radiological society of North America (RSNA) hands-on course in 3D printing
Creators: name: Chepelev, Leonid
name: Hodgdon, Taryn
name: Gupta, Ashish
name: Wang, Aili
name: Torres, Carlos
name: Satheesh Krishna
name: Akyuz, Ekin
name: Mitsouras, Dimitrios
name: Sheikh, Adnan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Mental Health

description: Creating Holes and Labeling. (DOCX 193 kb)
De‐Mystifying the Clone‐Censor‐Weight Method for Causal Research Using Observational Data: A Primer for Cancer Researchers
Creators: name: Ribeiro, Tatiane B.
name: Gaber, Charles E.
name: Du, Wei
name: Salas, Maribel
name: Maringe, Camille
name: Lund, Jennifer L.
name: Strassle, Paula D.
name: Garcia‐Albeniz, Xabier
name: Ghazarian, Armen A.
name: Wyss, Richard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description:
Regulators and oncology healthcare providers are increasingly interested in using observational studies of real‐world data (RWD) to complement clinical evidence from randomized controlled trials for informed decision‐making. To generate valid evidence, RWD studies must be carefully designed to avoid systematic biases. The clone‐censor‐weight (CCW) method has been proposed to address immortal time and other time‐related biases. The objective of this manuscript is to de‐mystify the CCW method for cancer researchers by describing and presenting its core components in an accessible and digestible format, using visualizations and examples from cancer‐relevant studies. The CCW method has been applied in diverse settings, including investigations of the effects of surgery within a certain time after cancer diagnosis, the continuation of annual screening mammography, and chemotherapy duration on survival. The method handles complex data wherein the treatment group to which an individual belongs is unknown at the start of follow‐up. The three steps of the CCW method involve cloning or duplicating the patient population and assigning one clone to each treatment strategy, artificially censoring the clones when their observed data are inconsistent with the assigned strategy and weighting the cloned and censored population to address selection bias created by the artificial censoring. The CCW method is a powerful tool for designing RWD studies in cancer that are free from time‐related biases and successfully, to the extent possible, emulate features of a randomized clinical trial. The clone‐censor‐weight (CCW) method has been proposed to address time‐related biases in causal research using observational data. The goal of this paper is to de‐mystify the CCW method through: (1) a narrative review of current applications in the cancer literature, (2) visual presentation and description of the CCW design and analytic components, (3) application of these visuals to several cancer case studies, and (4) discussion of important considerations and future directions.
title: My Hanuman Chalisa
Creators: name: ซิมมี่ อุปรา
Publisher: name: สถาบันเอเชียศึกษา
publisherIdentifierScheme: ROR
Year: 2024
Subjects: บทสวดสรรเสริญหนุมาน
บทวิจารณ์

description: เอเชียปริทัศน์, 45, 1, 70-83
A Randomized Trial Comparing Inhaled Insulin Plus Basal Insulin Versus Usual Care in Adults With Type 1 Diabetes.
Creators: name: Levy, Carol J
name: Codorniz, Kevin
name: Pickering, David
name: Castorino, Kristin
name: Nguyen, Quang T
name: Bhargava, Anuj
name: Blevins, Thomas
name: Manessis, Anastasios
name: Calhoun, Peter
name: Kurek, Corey
name: Donahue, Cassandra
name: Beck, Roy W
name: Kipnes, Mark
name: Rizvi, Shafaq
name: Frey, Sarah
name: Ruedy, Katrina J
name: Raskin, Philip
name: Jacobson, Christopher
name: Marak, Martin C
name: O'Malley, Grenye
name: Klein, Klara Rachel
name: Church, Mei Mei
name: Weinstock, Ruth S
name: Borgman, Sarah
name: Atakov Castillo, Astrid
name: Haider, Zehra
name: Steenkamp, Devin W
name: Lee, Scott
name: Akturk, Halis K
name: Buse, John B
name: Baran, Jesica D
name: Aleppo, Grazia
name: Hamdy, Osama
name: Bode, Bruce W
name: Tamarez, Denisa
name: Mottalib, Adham
name: Kudva, Yogish
name: Diner, Jamie
name: Desjardins, Donna
name: Hirsch, Irl B
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description:
OBJECTIVE: To evaluate a regimen of inhaled Technosphere insulin (TI) plus insulin degludec in adults with type 1 diabetes, who prestudy were predominately using either an automated insulin delivery (AID) system or multiple daily insulin injections (MDI) with continuous glucose monitoring. RESEARCH DESIGN AND METHODS: At 19 sites, adults with type 1 diabetes were randomly assigned to TI plus insulin degludec (N = 62) or usual care (UC) with continuation of prestudy insulin delivery method (N = 61) for 17 weeks. RESULTS: Prestudy, AID was used by 48% and MDI by 45%. Mean ± SD HbA1c was 7.57% ± 0.97% at baseline and 7.62% ± 1.06% at 17 weeks in the TI group and 7.59% ± 0.80% and 7.54% ± 0.77%, respectively, in the UC group (adjusted difference 0.11%, 95% CI -0.10 to 0.33, P value for noninferiority = 0.01). HbA1c improved from baseline to 17 weeks by >0.5% (5.5 mmol/mol) in 12 (21%) in the TI group and in 3 (5%) in the UC group and worsened by >0.5% (5.5 mmol/mol) in 15 (26%) in the TI group and in 2 (3%) in the UC group. The most common TI side effect was a brief cough; eight participants discontinued TI due to side effects. CONCLUSIONS: In adults with type 1 diabetes, HbA1c after 17 weeks with a regimen of TI and degludec was noninferior to UC, which consisted predominately of either AID or MDI. TI should be considered an option for people with type 1 diabetes, particularly those who are motivated to further reduce postprandial hyperglycemia.
Additional file 2: of MiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to loss of the HES1/Notch1 regulatory circuit
Creators: name: Spitschak, Alf
name: Meier, Claudia
name: Kowtharapu, Bhavani
name: Engelmann, David
name: Pützer, Brigitte
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Hematology
subject: 60506 Virology

description: Figure S1. Inhibition of ubiquitin-dependent degradation of intracellular active Notch1. a-b Effect of inhibitor MG-132 on cleaved Notch1 and HES1 expression inNThy.miR-182 (a), NThy-ori 3.1 and NThy.scr transfected with shHES1 or control (b). Cells were treated with 40 μM MG-132 or equal amount of DMSO for 5 h and at 24 h post transfection. Expression of cleaved Notch1 and HES1 were analyzed by WB. Actin was used as loading control. (PDF 3001 kb)
The Featherweight Giant: Unraveling the Atmosphere of a 17 Myr Planet with JWST
Creators: name: Tofflemire, Benjamin M.
name: Sandoval, Angeli
name: Barber, Madyson G.
name: Duvvuri, Girish M.
name: Bean, Jacob L.
name: Brown, Alexander
name: Kempton, Eliza M.-R.
name: Rizzuto, Aaron
name: Welbanks, Luis
name: Newton, Elisabeth R.
name: Thorngren, Daniel
name: Froning, Cynthia S.
name: Batalha, Natasha E.
name: Mann, Andrew W.
name: Gao, Peter
name: Schneider, P. Christian
name: Pineda, J. Sebastian
name: Murray, Catriona Anne
name: Thao, Pa Chia
name: Evans-Soma, Thomas M.
name: Feinstein, Adina D.
name: Wilson, David J.
name: Kraus, Adam L.
name: Longo, Isabella
name: Rotman, Yoav
name: Vanderburg, Andrew
name: Miguel, Yamila
name: Berta-Thompson, Zachory K.
name: Youngblood, Allison
name: Tsai, Shang-Min
name: France, Kevin
name: Wood, Mackenna L.
Publisher: name: American Astronomical Society
Year: 2024

description:
The characterization of young planets (<300 Myr) is pivotal for understanding planet formation and evolution. We present the 3–5 μm transmission spectrum of the 17 Myr, Jupiter-size (R ∼10R ⊕) planet, HIP 67522b, observed with JWST NIRSpec/G395H. To check for spot contamination, we obtain a simultaneous g-band transit with the Southern Astrophysical Research Telescope. The spectrum exhibits absorption features 30%–50% deeper than the overall depth, far larger than expected from an equivalent mature planet, and suggests that HIP 67522b’s mass is <20 M ⊕ irrespective of cloud cover and stellar contamination. A Bayesian retrieval analysis returns a mass constraint of 13.8 ± 1.0 M ⊕. This challenges the previous classification of HIP 67522b as a hot Jupiter and instead, positions it as a precursor to the more common sub-Neptunes. With a density of <0.10 g cm−3, HIP 67522 b is one of the lowest-density planets known. We find strong absorption from H2O and CO2 (≥7σ), a modest detection of CO (3.5σ), and weak detections of H2S and SO2 (≃2σ). Comparisons with radiative-convective equilibrium models suggest supersolar atmospheric metallicities and solar-to-subsolar C/O ratios, with photochemistry further constraining the inferred atmospheric metallicity to 3 × 10 solar due to the amplitude of the SO2 feature. These results point to the formation of HIP 67522b beyond the water snowline, where its envelope was polluted by icy pebbles and planetesimals. The planet is likely experiencing substantial mass loss (0.01–0.03 M ⊕ Myr−1), sufficient for envelope destruction within a gigayear. This highlights the dramatic evolution occurring within the first 100 Myr of its existence.
Additional file 2: of MiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to loss of the HES1/Notch1 regulatory circuit
Creators: name: Spitschak, Alf
name: Meier, Claudia
name: Kowtharapu, Bhavani
name: Engelmann, David
name: Pützer, Brigitte
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Hematology
subject: Virology

description: Figure S1. Inhibition of ubiquitin-dependent degradation of intracellular active Notch1. a-b Effect of inhibitor MG-132 on cleaved Notch1 and HES1 expression inNThy.miR-182 (a), NThy-ori 3.1 and NThy.scr transfected with shHES1 or control (b). Cells were treated with 40 μM MG-132 or equal amount of DMSO for 5 h and at 24 h post transfection. Expression of cleaved Notch1 and HES1 were analyzed by WB. Actin was used as loading control. (PDF 3001 kb)
MOESM3 of Leveraging 3D chemical similarity, target and phenotypic data in the identification of drug-protein and drug-adverse effect associations
Creators: name: Vilar, Santiago
name: Hripcsak, George
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 3: Figure S2. ROC curves for the drug-target predictors developed with 3D molecular similarity and 2D molecular similarity.
ETILENDAN VINILASETATNING KATALITIK SINTEZI VA TEXNOLOGIYASI
Creators: name: Omanov, Behruzjon
name: Allanazarova, Oydin
Publisher: name: Zenodo
Year: 2024

description: Mazkur tadqiqot etilendan asetat olish jarayonlarining kinetika va texnologik jihatlarni oʻrganishga bagʻishlangan. Ushbu ishda etilendan vinilasetatning katalitik sintezi va ushbu jarayon optimallashtirish texnologiyasi yoritilgan. Vinilasetat kimyo sanoatida polimerlar, qoplama materiallari, elimlar va boshqa mahsulotlarni ishlab chiqarishda asosiy xomashyo hisoblanadi. Uning etilendan sintezi hozirgi zamonaviy texnologiyalar va samarali katalizatorlarni qoʻllash bilan yuqori hosildorlikka erishishga imkon beradi. Katalizatorning samaradorligini saqlash uchun regenetorlarda qayta tiklash amalga oshiriladi. Bu ekologik xavfsizlikni taʼminlash va ishlab chiqarish tannarxi kamaytiradi. Etilendan vinilasetatning katalitik sintezi va texnologiyasi yuqori samaradorligi va ekologik tozaligi bilan zamonaviy kimyo sanoati uchun strategik ahamiyatga ega.
Additional file 1: Table S1. of Good syndrome and other causes of cytomegalovirus retinitis in HIV-negative patientsâ  case report and comprehensive review of the literature
Creators: name: Downes, Kenneth
name: Tarasewicz, Dariusz
name: Weisberg, Laurie
name: Cunningham, Emmett
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Summary of reported cases of cytomegalovirus (CMV) retinitis in immunocompetent HIV-negative patients. (DOC 497 kb)
Aonidella Maciolek
Creators: name: Delgado-Blas, Victor Hugo
name: Salazar-Silva, Patricia
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Polychaeta
Spionida
Spionidae
Aonidella

description: Genus Aonidella Maciolek in López-Jamar, 1989
Aonidella Maciolek in López-Jamar, 1989: 107 –110.
Type species: Prionospio cirrobranchiata Day, 1961, designated by Maciolek, 1983.
Aonidella cirrobranchiata (Day, 1961)
Prionospio cirrobranchiata Day, 1961: 488, fig. 4a–d. — Ibarzabal, 1986: 13. Minuspio cirrobranchiata. — Foster, 1971a: 108.
Prionospio (Minuspio) cf. cirrobranchiata.— Johnson, 1984: 6.58–6.59, figs 6.47–6.48. Aonidella cirrobranchiata. — Maciolek, 2000: 530 –531, fig. 1.
Type locality. Cape Coast, South Africa (34°11´S, 18°13´E), 144 m, sandy mud; paratypes, South-West Africa (34º17´S, 17º53´E), 320 m, black and green sand and mud.
Type material. Holotype not located, paratypes (BMNH ZK 1961.9.480/1).
Records. USA: off Florida and Texas, 15–90 m, coarse to fine sand (Johnson, 1984). Cuba: Batabano (Ibarzabal 1986).
Remarks. The presence of Aonidella cirrobranchiata (Day, 1961) in the Grand Caribbean is questionable. Specimens of Johnson (1984) and Ibarzabal (1986) require examination, because these specimens differ from A. cirrobranchiata (Day, 1961), in having a slight medial indentation on the prostomium, four eyes instead of none, and hooded hooks with 2–4 apical teeth instead of one.
description: Published as part of Delgado-Blas, Victor Hugo & Salazar-Silva, Patricia, 2011, Taxonomic catalogue of the Spionidae (Annelida: Polychaeta) of the Grand Caribbean, pp. 39-66 in Zootaxa 2782 on pages 40-41, DOI: 10.5281/zenodo.206833
Cyclorhipidion Hagedorn 1912
Creators: name: Hoebeke, E. Richard
name: Rabaglia, Robert J.
name: Knížek, Miloš
name: Weaver, John S.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Cyclorhipidion

description: Key to female Cyclorhipidion occurring in North America
1 Body length short, 1.82–2.16 mm; elytra pale yellowish brown (Figs. 1, 2); elytral declivity dull, almost flat, not impressed between interstriae 1 and 3; pronotum longer than wide (pronotal length/width ratio = 1.17–1.25); declivital strial punctures large, shallow, distinct, with interior surfaces reticulate, separated by less than their diameter, and denticles on declivital interstriae 1 and 3 small and more or less uniform in size (Fig.5)..................................... bodoanum (Reitter)
- Body length large, more than 2.4 mm; elytra chestnut brown to blackish brown; elytral declivity shining, impressed between interstriae 1 and 3; pronotum only slightly longer than wide or nearly quadrate (pronotal length/width ratio ± 1.17); declivital strial punctures smaller and reticulate, generally separated at least by their diameter or slightly more; denticles on declivital interstriae 1 and 3 larger than others...................................................................... 2
2 Body length 2.45–2.76 mm; declivital interstriae 2 slightly impressed (Fig. 6); elytra chestnut-brown; strial punctures and interstrial punctures on elytral declivity of equal size, confused (Fig. 6); pronotal length/width ratio = 1.07–1.17.................................................................................................. fukiense (Eggers)
- Body length 3.07–3.36 mm; declivital interstriae 2 noticeably impressed (Fig. 7); elytra blackish-brown; strial punctures on elytral declivity clearly distinct and larger than interstrial punctures, distinctly seriate (Fig. 7); pronotal length/width ratio = 1.06–1.16.......................................................................... pelliculosum (Eichhoff)
description: Published as part of Hoebeke, E. Richard, Rabaglia, Robert J., Knížek, Miloš & Weaver, John S., 2018, First records of Cyclorhipidion fukiense (Eggers) (Coleoptera: Curculionidae: Scolytinae: Xyleborini), an ambrosia beetle native to Asia, in North America, pp. 243-250 in Zootaxa 4394 (2) on page 248, DOI: 10.11646/zootaxa.4394.2.7, http://zenodo.org/record/1197696