cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Impedance Spectroscopy: Recent Developments as a Process Analytical Technology for Pharmaceutical Freeze-Drying. Lyophilization Summit 13-14th February, Prague.
Creators: name: Smith, Geoff
name: Yowwares Jeeraruangrattana (Dmu Email)
Publisher: name: De Montfort University
Year: 2020
Subjects: subject: 111504 Pharmaceutical Sciences
subject: FOS: Clinical medicine

description: cite as:Smith, G. (2019). Impedance Spectroscopy: Recent Developments as a Process Analytical Technology for Pharmaceutical Freeze-Drying. Podium presentation at Qepler Lyophilization Summit 13-14 Feb, Prague

Podium presentation describing the application of through vial impedance spectroscopy in the determination of nucleation temperatures and solidification end points. TVIS dielectric loss parameters Fpeak and Cpeak and the dielectric storage at low frequency (e.g. 10 or 100 Hz) appear to offer the opportunity for the registration of the nucleation point for the onset of ice growth. In addition the dielectric storage at high frequency (e.g. 200 kHz) shows little temperature sensitivity and so is an ideal measurement frequency for assessing the end point of ice solidification. Post solidification, the parameter log Fpeak can then be redeployed to determine the point at which all excess latent heat has left the sample and the product temperature then equilibrates with the shelf. This work paves the way for the determination of a new critical process parameter based on the time interval between ice growth onset and ice solidification end point (alongside the ice nucleation temperature).
Content of the presentation:1. Introduction
2. Dielectric loss mechanisms
3. TVIS Theory
4. What frequency for what process?
5. Observations on ice (Ice nucleation and growth; ice solidification end point)
Electromagnetic Spectrum from QGP Fluid
Creators: name: Hirano, T.
name: Muroya, S.
name: Namiki, M.
Publisher: name: arXiv
Year: 1997
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We calculate thermal photon and electron pair distribution from hot QCD matter produced in high energy heavy-ion collisions, based on a hydrodynamical model which is so tuned as to reproduce the recent experimental data at CERN SPS, and compare these electromagnetic spectra with experimental data given by CERN WA80 and CERES. We investigate mainly the effects of the off-shell properties of the source particles on the electromagnetic spectra.
description: 5 pages, latex, 4 Postscript figures. A talk given at the International School on the Physics of Quark Gluon Plasma, June 3-6, 1997, Hiroshima, Japan. To be appeared in Prog. Theor. Phys. Supplement
title: Osteoporose bei systemischer Mastozytose: Ergebnisse von 1.374 Beckenkammbiopsien
Creators: name: Gehlen, Martin
name: Schmidt, Niels
name: Hinz, Christian
name: Pfeifer, Michael
name: Lazarescu, Ana Doina
name: Schwarz-Eywill, Michael
name: Siggelkow, Heide
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Unter einer Mastozytose versteht man eine Gruppe seltener Erkrankungen mit einer klonalen Vermehrung von Mastzellen in einem oder mehreren Organen. Die systemische Mastozytose kann Ursache einer sekundären Osteoporose sein. Im Rahmen dieser Studie sollten die Zahlen zur Diagnose in [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
The Circular Velocity Curve of the Milky Way from $5$ to $25$ kpc
Creators: name: Eilers, Anna-Christina
name: Hogg, David W.
name: Rix, Hans-Walter
name: Ness, Melissa
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We measure the circular velocity curve $v_{\rm c}(R)$ of the Milky Way with the highest precision to date across Galactocentric distances of $5\leq R \leq 25$ kpc. Our analysis draws on the $6$-dimensional phase-space coordinates of $\gtrsim 23,000$ luminous red-giant stars, for which we previously determined precise parallaxes using a data-driven model that combines spectral data from APOGEE with photometric information from WISE, 2MASS, and Gaia. We derive the circular velocity curve with the Jeans equation assuming an axisymmetric gravitational potential. At the location of the Sun we determine the circular velocity with its formal uncertainty to be $v_{\rm c}(R_{\odot}) = (229.0\pm0.2)\rm\,km\,s^{-1}$ with systematic uncertainties at the $\sim 2-5\%$ level. We find that the velocity curve is gently but significantly declining at $(-1.7\pm0.1)\rm\,km\,s^{-1}\,kpc^{-1}$, with a systematic uncertainty of $0.46\rm\,km\,s^{-1}\,kpc^{-1}$, beyond the inner $5$ kpc. We exclude the inner $5$ kpc from our analysis due to the presence of the Galactic bar, which strongly influences the kinematic structure and requires modeling in a non-axisymmetric potential. Combining our results with external measurements of the mass distribution for the baryonic components of the Milky Way from other studies, we estimate the Galaxy's dark halo mass within the virial radius to be $M_{\rm vir} = (7.25\pm0.26)\cdot 10^{11}M_{\odot}$ and a local dark matter density of $ρ_{\rm dm}(R_{\odot}) = 0.30\pm0.03\,\rm GeV\,cm^{-3}$.
description: Accepted for publication in ApJ. All data can be downloaded here: https://doi.org/10.5281/zenodo.1468053
Estimating the potential impact of Australia's reformulation programme on households' sodium purchases
Creators: name: Popkin B
name: Ni Mhurchu C
name: Wu J
name: Coyle D
name: Santos M
name: Neal B
name: Shahid M
name: Marklund M
name: Trieu K
name: McKee S
name: Dunford E
Publisher: name: BMJ Publishing Group
Year: 2021

description: Background On average, Australian adults consume 3500 mg sodium per day, almost twice the recommended maximum level of intake. The Australian government through the Healthy Food Partnership initiative has developed a voluntary reformulation programme with sodium targets for 27 food categories. We estimated the potential impact of this programme on household sodium purchases (mg/day per capita) and examined potential differences by income level. We also modelled and compared the effects of applying the existing UK reformulation programme targets in Australia. Methods This study used 1 year of grocery purchase data (2018) from a nationally representative consumer panel of Australian households (Nielsen Homescan) that was linked with a packaged food and beverage database (FoodSwitch) that contains product-specific sodium information. Potential reductions in per capita sodium purchases were calculated and differences across income level were assessed by analysis of variance. All analyses were modelled to the Australian population in 2018. Results A total of 7188 households were included in the analyses. The Healthy Food Partnership targets covered 4307/26 728 (16.1%) unique products, which represented 22.3% of all packaged foods purchased by Australian households in 2018. Under the scenario that food manufacturers complied completely with the targets, sodium purchases will be reduced by 50 mg/day per capita, equivalent to 3.5% of sodium currently purchased from packaged foods. Reductions will be greater in low-income households compared with high-income households (mean difference-7 mg/day, 95% CI-4 to-11 mg/day, p<0.001). If Australia had adopted the UK sodium targets, this would have covered 9927 unique products, resulting in a reduction in per capita sodium purchases by 110 mg/day. Conclusion The Healthy Food Partnership reformulation programme is estimated to result in a very small reduction to sodium purchases. There are opportunities to improve the programme considerably through greater coverage and more stringent targets.
title: Potentials of 3D Map Printing for Individuals with Alzheimer’s Disease
Creators: name: Reese, Daniel G
Publisher: name: George Mason University
Year: 2017
Subjects: subject: 3D map printing
subject: Alzheimers Disease
subject: Rapid prototyping
subject: Cartographic media

description: This document has been embargoed for 1 year and will not be available until June 2017.
description: An estimated 5.2 million people in the United States have been diagnosed with Alzheimer’s disease (AD), a figure that is forecasted to increase as cures for other diseases are discovered that improve life expectancy. A major effect of AD is a decrease in spatial cognitive abilities, capabilities that allow individuals to interpret and navigate their immediate surroundings. Past research attempted to indicate how and why AD affects spatial cognition, however none have investigated the introduction of cartographic media to assist with these limitations. Technological advancements have the potential to bridge the divide between spatial cognition loss and cartographic media. Rapid prototyping shows promise for developing three-dimensional (3D) printed cartographic media for various applications. This thesis aims to identify AD stages that would mostly benefit from cartographic media, whether 3D printed media has the potential to improve spatial cognition, and which cartographic design criteria might be appropriate for assisting AD population groups. The outcome of this thesis will be the production of 3D printed maps, demonstrating initial cartographic opportunities in AD patient independence.
Evaluating the actual and perceived effectiveness of E-cigarette prevention advertisements among adolescents
Creators: name: Prentice-Dunn H
name: Brewer N.T
name: Noar S.M
name: Kresovich A
name: Hall M.G
name: Rohde J.A
Publisher: name: Elsevier Ltd
Year: 2020

description: Background: The efficacy of e-cigarette prevention ads among adolescents has seldom been studied. We examined the impact of ads from the The Real Cost vaping prevention media campaign on what adolescents think and believe about vaping. We also sought to test whether perceived message effectiveness (PME) served as a proxy for ad impact. Methods: Participants were 543 U.S. adolescents ages 13–17. In an online experiment, we randomized participants to either: 1) persuasive e-cigarette prevention video ads from the Food and Drug Administration's The Real Cost campaign that was targeted to adolescents or 2) information-only e-cigarette harms control videos (control condition). Participants in each condition viewed 2 videos in a random order. After ad exposure, the survey assessed PME (message and effects perceptions), risk beliefs about vaping, attitudes toward vaping, and intentions to vape. Results: The FDA's The Real Cost ads led to higher beliefs about the harms of vaping (p < .001), more negative attitudes toward vaping (p < .001), and lower intentions to vape (p < .05) compared to the control videos. The Real Cost ads also scored higher on both message perceptions (p < .001) and effects perceptions (p < .001) compared to control videos. Effects perceptions were associated with all three outcomes (all ps < 0.001, adjusting for both types of PME and covariates), but message perceptions did not offer additional predictive value. Conclusions: Exposure to The Real Cost vaping prevention ads gave adolescents a more negative view of vaping and lowered their intentions to vape compared to control videos. Effects perceptions may be superior to message perceptions as a proxy for e-cigarette prevention ad impact.
title: Exploring self-compassion, positive and negative emotion regulation, sport performance, and resilience among college athletes
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2021

description: It is the most resilient athletes – those who bounce back from adversity – who achieve the most success and fulfillment while maintaining well-being throughout their college careers. To better understand the psychological profiles of resilient athletes, researchers often focus on emotion regulation strategies in response to negative events. While fruitful, athletes’ regulatory responses to positive events (e.g., savoring) may be equally important during the highs, lows, and rigorous demands of a collegiate season. Researchers are also becoming increasingly interested in self-compassion (SC) as an emotion protective factor among athletes. SC may be crucial in helping athletes overcome shortcomings and defeats in sports. However, it remains unclear whether SC influences the regulation of positive and negative emotions and daily sport performance, particularly on days following poor performances (as SC theory would suggest). Lastly, while research is beginning to examine the role of SC in athletes, it is unclear whether benefits are unique or shared by related traits, such as grit, hope, and self-confidence. In Study 1, I compare the effects of frequently studied negative emotion regulation strategies (cognitive reappraisal and acceptance) to a positive emotion regulation strategy (savoring) on daily emotional resilience in response to negative events. In Study 2, I explore whether individual differences in SC influence chosen emotion regulation strategies, enhance their effectiveness, and facilitate resilient responses to poor sport performances the following day (in terms of performance and emotional rebound) while comparing the effects of SC with grit, hope, and self-confidence.
Unsupervised 3D End-to-End Medical Image Registration with Volume Tweening Network
Creators: name: Zhao, Shengyu
name: Lau, Tingfung
name: Luo, Ji
name: Chang, Eric I-Chao
name: Xu, Yan
Publisher: name: arXiv
Year: 2019
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: 3D medical image registration is of great clinical importance. However, supervised learning methods require a large amount of accurately annotated corresponding control points (or morphing), which are very difficult to obtain. Unsupervised learning methods ease the burden of manual annotation by exploiting unlabeled data without supervision. In this paper, we propose a new unsupervised learning method using convolutional neural networks under an end-to-end framework, Volume Tweening Network (VTN), for 3D medical image registration. We propose three innovative technical components: (1) An end-to-end cascading scheme that resolves large displacement; (2) An efficient integration of affine registration network; and (3) An additional invertibility loss that encourages backward consistency. Experiments demonstrate that our algorithm is 880x faster (or 3.3x faster without GPU acceleration) than traditional optimization-based methods and achieves state-of-theart performance in medical image registration.
description: Journal of Biomedical and Health Informatics
Evaluating the efficacy of a priming dose of cyclophosphamide prior to pembrolizumab to treat metastatic triple negative breast cancer
Creators: name: Calhoun, B.C
name: Gudena, V
name: Moore, D.T
name: Anders, C.K
name: Bortone, D
name: Jankowitz, R
name: Van Swearingen, A.E.D
name: Cowens, K
name: Reeder-Hayes, K
name: Woodcock, M.G
name: McKinnon, K
name: Kaltman, R
name: Garrett, A.L
name: Serody, J.S
name: Perou, C
name: Cuaboy, L.A
name: Kolupaev, O
name: Muss, H
name: Vincent, B.G.
name: Carey, L.
name: Olajide, O
name: Laurie, S
name: Robeson, A
name: Wilkinson, A.D.
name: Sambade, M.J
name: Dees, E.C.
name: Jolly, T
Publisher: name: BMJ Publishing Group
Year: 2022

description: PurposeTriple negative breast cancer (TNBC) is characterized by the presence of immune cells in the tumor microenvironment, however, the response to single-agent immune checkpoint inhibitor (ICI) therapy is modest. Preclinical models have demonstrated that intratumoral regulatory T cells (Tregs) dampen the antitumor response to ICI. We performed a single-arm phase II trial to evaluate the efficacy of a single low dose of cyclophosphamide (Cy) to deplete Tregs administered before initiating pembrolizumab.Patients and methods40 patients with pretreated metastatic TNBC were enrolled. The primary endpoints were progression-free survival (PFS) and change in peripheral blood Tregs after Cy. Secondary endpoints included overall response rate (ORR), duration of response, overall survival, treatment-related adverse events (AEs), and correlative evaluations.ResultsMedian PFS was 1.8 months, and the ORR was 21%. Tregs were not significantly decreased after Cy prior to ICI (−3.3%, p=0.19), and increased significantly after the first cycle of therapy (+21% between cycles 1 and 2, p=0.005). Immune-related AEs were similar to historical pembrolizumab monotherapy, and were associated with response to therapy (p=0.02). Patients with pretreatment tumors harboring increased expression of B cell metagene signatures and increased circulating B cell receptor repertoire diversity were associated with clinical response and immune-related toxicity (IRT).ConclusionsAmong patients with heavily pretreated TNBC, Cy prior to pembrolizumab did not significantly deplete Tregs, and in those with decreased numbers there was rapid recovery following therapy. Increased B cell gene expression in baseline samples was associated with clinical response and IRT.
Predictions for energy correlators probing substructure of groomed heavy quark jets
Creators: name: Lee, Christopher
name: Shrivastava, Prashant
name: Vaidya, Varun
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We develop an effective field theory (EFT) framework to perform an analytic calculation for energy correlator observables computed on groomed heavy-quark jets. A soft-drop grooming algorithm is applied to a jet initiated by a massive quark to minimize soft contamination effects such as pile-up and multi-parton interactions. We specifically consider the two-particle energy correlator as an initial application of this EFT framework to compute heavy quark jet substructure. We find that there are different regimes for the event shapes, depending on the size of the measured correlator observable, that require the use of different EFT formulations, in which the quark mass and grooming parameters may be relevant or not. We use the EFT to resum large logarithms in the energy correlator observable in terms of the momentum of a reconstructed heavy hadron to NLL$'$ accuracy and subsequently match it to a full QCD $\mathcal{O}(α_s)$ cross section, which we also compute. We compare our predictions to simulations in PYTHIA for $e^+e^-$ collisions. We find a good agreement with partonic simulations, as well as hadronic ones with an appropriate shape function used to describe nonperturbative effects and the heavy quark hadron decay turned off. We also predict the scaling behavior for the leading nonperturbative power correction due to hadronization. Consequently, we can give a prediction for the energy correlator distribution at the level of the reconstructed heavy hadron. This work provides a general framework for the analysis of heavy quark jet substructure observables.
description: 50 pages, 16 figures. v2: improved discussions of phase space boundaries and transition points in EFT vs. fixed-order computations, numerous other minor clarifications and corrections. v3: minor clarifications and corrections, version published in JHEP
Ocnerodrilidae
Creators: name: Bartz, Marie L. C.
name: Barreto, Julia
name: Santos, Alessandra
name: Dudas, Rafaela T.
name: Ferreira, Talita
name: Maia, Lilianne Dos Santos
name: Demetrio, Wilian C.
name: Smokanit, Manoela
name: Tavares, Alan A.
name: Schuster, Phillip A.
name: Hernani, Luis C.
name: Brown, George G.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Ocnerodrilidae

description: Ocnerodrilidae sp.1   BRPR09567, 71 adults, surface soil under no-tillage in Rolândia — PR (23°19’9.22”S; 51°27’1.02”W), December 2016. M.L.C. Bartz, W.C. Demetrio, H.S. Nadolny, T. Ferreira, L.S. Maia, M. Smokanit, R. T. Dudas, A.A. T. Tavares, P.A. Shcuster colls. BRPR0968, 213 adults, surface soil under no-tillage in Rolândia — PR (23°19’18.51”S; 51°27’02.55”W), December 2016. M.L.C. Bartz, W.C. Demetrio, H.S. Nadolny, T. Ferreira, L.S. Maia, M. Smokanit, R. T. Dudas, A.A. T. Tavares, P.A. Shcuster colls. BRPR0969, 6 adults, surface soil under no-tillage in Rolândia — PR (23°19’24.87”S; 51°27’06.23”W), December 2016. M.L.C. Bartz, W.C. Demetrio, H.S. Nadolny, T. Ferreira, L.S. Maia, M. Smokanit, R. T. Dudas, A.A. T. Tavares, P.A. Shcuster colls. BRPR0970, 166 adults, surface soil under no-tillage in Rolândia — PR (23°19’31.20”S; 51°27’9.82”W), December 2016. M.L.C. Bartz, W.C. Demetrio, H.S. Nadolny, T. Ferreira, L.S. Maia, M. Smokanit, R. T. Dudas, A.A. T. Tavares, P.A. Shcuster colls. BRPR0971, 6 adults, surface soil under no-tillage in Rolândia — PR (23°19’22.04”S; 51°27’27.45”W), December 2016. M.L.C. Bartz, W.C. Demetrio, H.S. Nadolny, T. Ferreira, L.S. Maia, M. Smokanit, R. T. Dudas, A.A. T. Tavares, P.A. Shcuster colls. BRPR0972, 96 adults, surface soil under no-tillage in Rolândia — PR (23°19’8.32”S; 51°27’37.62”W), December 2016. M.L.C. Bartz, W.C. Demetrio, H.S. Nadolny, T. Ferreira, L.S. Maia, M. Smokanit, R. T. Dudas, A.A. T. Tavares, P.A. Shcuster colls. BRPR0973, 43 adults, surface soil under no-tillage in Toledo — PR (24°48’50.56”S; 53°33’11.90”W), December 2016. M.L.C. Bartz, W.C. Demetrio, H.S. Nadolny, T. Ferreira, L.S. Maia, M. Smokanit, R. T. Dudas, A.A. T. Tavares, P.A. Shcuster colls.
description: Published as part of Bartz, Marie L. C., Barreto, Julia, Santos, Alessandra, Dudas, Rafaela T., Ferreira, Talita, Maia, Lilianne Dos Santos, Demetrio, Wilian C., Smokanit, Manoela, Tavares, Alan A., Schuster, Phillip A., Hernani, Luis C. & Brown, George G., 2023, Earthworm richness in no-tillage farming systems and riparian forests in Southern and Southeastern Brazil, pp. 362-376 in Zootaxa 5255 (1) on page 368, DOI: 10.11646/zootaxa.5255.1.29, http://zenodo.org/record/7745023
Supplementary Tables
Creators: name: Mansour, Omar
name: Golden, Sherita Hill
name: Hsin-Chieh Yeh
Publisher: name: figshare
Year: 2019
Subjects: subject: 111706 Epidemiology
subject: FOS: Health sciences
subject: 110306 Endocrinology
subject: FOS: Clinical medicine

description: Supplementary appendix: Sex and racial disparities in mortality among adults with and without diabetes in the modern era
Additional file 1 of Association of elastic power in mechanical ventilation with the severity of acute respiratory distress syndrome: a retrospective study
Creators: name: Xie, Yongpeng
name: Shi, Jiaxin
name: Liu, Suxia
name: Chen, Xiaobing
name: Wang, Yanli
name: Li, Xiaomin
name: Yan, Yao
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional fle 1: Table S1. Percentage of missing data in the variables of interest at baseline; Table S2. Respiratory mechanics parameters of the study population according to elastic power quartiles in the first 24 h; Table S3. Association between elastic power and moderate-severe ARDS in complete cases; Table S4. Association between elastic power and moderate-severe ARDS in the first 24 h; Table S5. Capability of related parameters in predicting moderate-severe ARDS occurrence in ARDS patients; Table S6. Factors associated with moderate-severe ARDS by of binary logistic regression analysis; Figure S1. The relationship between elastic power and moderate-severe ARDS according to basic features; Figure S2. Comparision of Receiver operating characteristic curves for [4ΔP + RR] and EP.
title: An Analysis of Constraints Faced by Military Veterans When Recreating at Outdoor Parks
Creators: name: Steinel, Jeremy
Publisher: name: George Mason University
Year: 2020
Subjects: subject: Veteran constraints
subject: Veterans and recreation
subject: Recreation constraints
subject: Outdoor recreation

description: This thesis presents a qualitative analysis of the constraints that veterans face when participating in recreation at outdoors. Often there are interpersonal, intrapersonal, and structural constraints that prevent people from participating. The kinds of constraints differ for distinctive groups based on individual needs, experiences, and challenges. Veterans, due to the unique lifestyle they experienced during their enlistment, have specific constraints that are relevant to them. There is a focus on utilizing the Theory of Planned Behavior to explain this phenomenon. The purpose of this research is to explore which unique constraints exist with veterans before and after their transition to civilian life, and analyze how that may impact their intention to participate in outdoor recreation.
Evaluating the Impact of Nonrandom Mating: Psychiatric Outcomes Among the Offspring of Pairs Diagnosed With Schizophrenia and Bipolar Disorder
Creators: name: Mataix-Cols D
name: Brander G
name: Sullivan P.F
name: Wray N.R
name: Larsson H
name: Nordsletten A.E
name: Lichtenstein P
name: Crowley J.J
Publisher: name: Elsevier USA
Year: 2020

description: Background: Nonrandom mating has been shown for psychiatric diagnoses, with hypothesized—but not quantified—implications for offspring liability. This national cohort study enumerated the incidence of major psychiatric disorders among the offspring of parent pairs affected with schizophrenia (SCZ) and/or bipolar disorder (BIP) (i.e., dual-affected pairs). Methods: Participants were all Swedish residents alive or born between 1968 and 2013 (n = 4,255,196 unique pairs and 8,343,951 offspring). Offspring with dual-affected, single-affected, and unaffected parents were followed (1973–2013) for incidence of broad psychiatric disorders. Primary outcomes included hazard ratio (HR) and cumulative incidence for SCZ and BIP in the offspring. Additional outcomes included any neuropsychiatric, anxiety, depressive, personality, or substance use disorders. Cumulative incidences of SCZ and BIP were used to inform heritability models for these disorders. Results: Hazards were highest within disorder (e.g., offspring of dual-SCZ pairs had sharply raised hazards for SCZ [HR = 55.3]); however, they were significantly raised for all diagnoses (HR range = 2.89–11.84). Incidences were significantly higher for the majority of outcomes, with 43.4% to 48.5% diagnosed with “any” disorder over follow-up. Risks were retained, with modest attenuations, for the offspring of heterotypic pairs. The estimated heritability of liability for SCZ (h2 = 0.62, 95% confidence interval = 0.55–0.70) and BIP (h2 = 0.52, 95% confidence interval = 0.46–0.58) did not differ significantly from estimates derived from single-affected parents. Conclusions: Risks for a broad spectrum of psychiatric diagnoses are significantly raised in the offspring of dual-affected parents, in line with expectations from a polygenic model of liability to disease risk. How these risks may contribute to population maintenance of these disorders is considered.
title: 5 Jahresergebnisse eines neuen biodegradierbaren Implantates für die Behandlung des Hallux rigidus bei Rheumatoider Arthritis und Osteoarthrose – eine prospektive randomisierte Studie
Creators: name: Hassel, Kathryn
name: Mai, Sabine
name: Mai, Burkhard
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die rheumatoide Arthritis sowie die fortgeschrittene Arthrose können zu schweren Deformierungen an den Füßen führen mit Schmerz, Bewegungseinschränkungen sowie Funktionsverlust der Großzehe. Die Langzeitergebnisse der Endoprothetik sind nach wie vor nicht zufrieden[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Additional file 1 of Network meta-analysis of invasive treatment for early-stage osteonecrosis of the femoral head
Creators: name: Li, Yingchun
name: Ma, Xiuying
name: Dong, Bo
name: Li, Yue
name: Liang, Zhuang
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Additional file 1: Figure S1. Forest map with results of HHS heterogeneity testing and node splitting method for inconsistency testing. Figure S2. Forest map with results of FR heterogeneity testing and node splitting method for inconsistency testing.
title: Tofacitinib promotes fundamental processes of bone healing
Creators: name: Gaber, Timo
name: Brinkman, Antonia
name: Pienczykowski, Justyna
name: Damerau, Alexandra
name: Pfeiffenberger, Moritz
name: Ehlers, Lisa
name: Buttgereit, Frank
name: Hoff, Paula
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Inflammatory diseases like rheumatoid arthritis (RA) and anti-inflammatory treatment of RA with glucocorticoids (GC) or NSAIDS negatively influence bone metabolism and fracture healing. Janus kinase (Jak) inhibition with tofacitinib has been demonstrated as a potent anti-inflammatory therapeutic[for full text, please go to the a.m. URL]
description: 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Fragmentation of Colliding Discs
Creators: name: Kun, F.
name: Herrmann, H. J.
Publisher: name: arXiv
Year: 1996
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: We study the phenomena associated with the low-velocity impact of two solid discs of equal size using a cell model of brittle solids. The fragment ejection exhibits a jet-like structure the direction of which depends on the impact parameter. We obtain the velocity and the mass distribution of the debris. Varying the radius and the initial velocity of the colliding particles, the velocity components of the fragments show anomalous scaling. The mass distribution follows a power law in the region of intermediate masses.
description: 23 pages, Latex, 13 Postscript figures included, Submitted to Int. J. of Mod. Phys. C
Osmotic Properties of Charged Cylinders: Critical Evaluation of Counterion Condensation Theory
Creators: name: Hansen, Per Lyngs
name: Podgornik, Rudi
name: Parsegian, V. Adrian
Publisher: name: arXiv
Year: 2000
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The osmotic coefficient of B-DNA in water may, in moderately dilute solutions, deviate as much as 100 % from predictions based on a simple 'counterion condensation' theory. We determine the results for osmotic properties via a cell model description of the ionic atmosphere near a cylindrical polyelectrolyte. The cell model predictions for the osmotic properties disagree with predictions based on simple condensation theory, but are in surprisingly good harmony with experimental findings. We argue that the neglect of finite-radius effects makes simple condensation theory inapplicable at all but impractically low polyelectrolyte concentrations and, unable to reproduce osmotic properties of polyelectrolytes such as DNA.
description: 9 pages, 2 figures
Evaluation of Between-County Disparities in Premature Mortality Due to Stroke in the US
Creators: name: Labresh, K.A
name: Ma, G
name: Song, S
name: Zheng, Z.-J
name: Smith, Jr., S.C
name: Jin, Y
name: Trisolini, M.G
Publisher: name: American Medical Association
Year: 2021

description: Importance: Identifying the factors associated with premature stroke mortality and measuring between-county disparities may provide insight into how to reduce variations and achieve more equitable health outcomes. Objective: To examine the between-county disparities in premature stroke mortality in the US, investigate county-level factors associated with mortality, and describe differences in mortality disparities by place of death and stroke subtype. Design, Setting, and Participants: This retrospective cross-sectional study linked the mortality and demographic data of US counties from the Centers for Disease Control and Prevention WONDER database to county-level characteristics from multiple databases. The outcome measure was county-level age-adjusted stroke mortality among adults aged 25 to 64 years in 2637 US counties from 1999 to 2018. This study was conducted from April 1, 2019, to October 31, 2020. Generalized linear Poisson regressions were fitted to investigate 4 sets of factors associated with county-level mortality: demographic composition, socioeconomic status, health care and environmental features, and population health. The Theil index score was calculated to assess the mortality disparities. Main Outcomes and Measures: Stroke mortality was measured as the number of deaths attributed to stroke in the data set. Out-of-stroke-unit death was defined as any death occurring in outpatient or emergency departments or at the pretransport location. Five stroke subtypes were included in the analysis. Results: Although mortality did not change substantially from 1999 to 2018 (from 12.62 to 11.81 per 100000 population), the proportion of deaths occurring out of the stroke unit increased from 23.56% (4328 of 18 369) to 34.57% (6978 of 20 188). A large percentage of stroke of an uncertain cause was reported, with most deaths (55.20%) occurring out of the stroke unit. In the county with the highest premature stroke mortality, the incidence was 20.78 times as high as that in the county with the lowest mortality (65.04 vs 3.13 deaths per 100000 population). The highest between-county disparities were found for stroke of uncertain cause. For out-of-stroke-unit death, county-level mortality was largely associated with demographic composition (31.6%) and health care and environmental features (25.8%). For in-hospital death, 29.8% of county-level mortality was associated with population health and 28.7% was associated with demographic composition. Conclusions and Relevance: These findings suggest that strategies addressing specific factors that underlie the mortality disparities among US counties, especially for out-of-stroke-unit death and stroke of uncertain cause, may be useful when tailored to the county-level context before implementing interventions for the neediest counties.
Smith (2018) Podium presentation at "Freeze Drying of Pharmaceutical and Biologicals", Sept 18 - 21, Garmisch-Partenkirchen, Germany
Creators: name: Smith, Geoff
name: Yowwares Jeeraruangrattana (Dmu Email)
Publisher: name: De Montfort University
Year: 2019
Subjects: subject: 111504 Pharmaceutical Sciences
subject: FOS: Clinical medicine

description: Podium presentation by Geoff Smith at the conference "Freeze-Drying of Pharmaceuticals and Biologics" in Garmisch-Partenkirchen, Germany, Sept 18-21 2018. The presentation describes the use of a dual-electrode, through vial impedance spectroscopy (TVIS) method for the determination of drying rates and the prediction of ice interface and ice base temperatures from which the single vial heat transfer coefficient was calculated.
title: Signaling pathways involved in visfatin-mediated induction of proinflammatory cytokines and MMPs during adipogenic MSC differentiation
Creators: name: Tsiklauri, Lali
name: Frommer, Klaus
name: Rehart, Stefan
name: Müller-Ladner, Ulf
name: Neumann, Elena
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Osteoporosis (OP) is the most common age-related disorder characterized by bone loss and correlates with increased bone marrow adiposity due to an imbalance between osteogenic and adipogenic differentiation potential of bone marrow mesenchymal stem cells (MSC). Adipocyte-derived factors [for full text, please go to the a.m. URL]
description: 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
title: AN, Registre des écrous du Châtelet, Y5266, f. p1000783
Creators: name: Claustre, Julie
name: Nationales, Archives
name: Archives Nationales
name: Claustre, Julie
name: ArchivesNationales/J.CLAUSTRE/H.REGAZZI/2020
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: registre
subject: Châtelet

description: Registre des écrous du Châtelet, Archives Nationales, Y5266. Numérisation en mode image.
description: Bibliographic citation: Archives Nationales, Registre des écrous du Châtelet, Y5266, f. p1000783
Perfection in motivic homotopy theory
Creators: name: Elmanto, Elden
name: Khan, Adeel A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Algebraic Geometry (math.AG)
subject: K-Theory and Homology (math.KT)
subject: FOS: Mathematics

description: We prove a topological invariance statement for the Morel-Voevodsky motivic homotopy category, up to inverting exponential characteristics of residue fields. This implies in particular that SH[1/p] of characteristic p>0 schemes is invariant under passing to perfections. Among other applications we prove Grothendieck-Verdier duality in this context.
description: 10 pages. v3: minor revisions; to appear in Proceedings of the LMS
Constraints on Finite Soft Supersymmetry Breaking Terms
Creators: name: Kobayashi, T.
name: Kubo, J.
name: Mondragon, M.
name: Zoupanos, G.
Publisher: name: arXiv
Year: 1998
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A new solution to the requirement of two-loop finiteness of the soft supersymmetry breaking terms (SSB) parameters is found in Finite-Gauge-Yukawa unified theories. The new solution has the form of a sum rule for the relevant scalar masses, relaxing the universality required by the previously known solution, which leads to models with unpleasant phenomenological consequences. Using the sum rule we investigate two Finite-Gauge-Yukawa unified models and we determine their spectrum in terms of few parameters. Some characteristic features of the models are that a) the old agreement of the top quark mass prediction with the measured value remains unchanged, b) the lightest Higgs mass is predicted around 120 GeV, c) the s-spectrum starts above 200 GeV.
description: Presented by G. Zoupanos at the ICHEP97, Jerusalem, Israel. 7 pages, 1 figure
The Matching Augmentation Problem: A $\frac74$-Approximation Algorithm
Creators: name: Cheriyan, Joe
name: Dippel, Jack
name: Grandoni, Fabrizio
name: Khan, Arindam
name: Narayan, Vishnu V.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences
subject: 68W25, 90C59, 90C27, 68R10, 05C85

description: We present a $\frac74$ approximation algorithm for the matching augmentation problem (MAP): given a multi-graph with edges of cost either zero or one such that the edges of cost zero form a matching, find a 2-edge connected spanning subgraph (2-ECSS) of minimum cost. We first present a reduction of any given MAP instance to a collection of well-structured MAP instances such that the approximation guarantee is preserved. Then we present a $\frac74$ approximation algorithm for a well-structured MAP instance. The algorithm starts with a min-cost 2-edge cover and then applies ear-augmentation steps. We analyze the cost of the ear-augmentations using an approach similar to the one proposed by Vempala and Vetta for the (unweighted) min-size 2-ECSS problem (`Factor 4/3 approximations for minimum 2-connected subgraphs,' APPROX 2000, LNCS 1913, pp.262-273).
description: [v2]: based on a thorough journal review, the submission has been revised to improve the exposition, though the results and proofs are the same (modulo expository improvements); there are several changes, mostly in sections 4, 5, 6; more informal discussion (of the credit scheme) has been added in sections 5.2 and 5.3; nevertheless, sections 4.4 and 5.3 need patience and effort
Ocnerodrilidae
Creators: name: Bartz, Marie L. C.
name: Barreto, Julia
name: Santos, Alessandra
name: Dudas, Rafaela T.
name: Ferreira, Talita
name: Maia, Lilianne Dos Santos
name: Demetrio, Wilian C.
name: Smokanit, Manoela
name: Tavares, Alan A.
name: Schuster, Phillip A.
name: Hernani, Luis C.
name: Brown, George G.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Ocnerodrilidae

description: Ocnerodrilidae sp.15   BRSP0230, 11 individuals, surface soil under riparian forest in Itaí—SP (23°33’50.75”S; 49°04’56.88”W), December 2017. M.L.C. Bartz, H.S. Nadolny, J. Barreto, A. Santos, G.G. Brown colls.
description: Published as part of Bartz, Marie L. C., Barreto, Julia, Santos, Alessandra, Dudas, Rafaela T., Ferreira, Talita, Maia, Lilianne Dos Santos, Demetrio, Wilian C., Smokanit, Manoela, Tavares, Alan A., Schuster, Phillip A., Hernani, Luis C. & Brown, George G., 2023, Earthworm richness in no-tillage farming systems and riparian forests in Southern and Southeastern Brazil, pp. 362-376 in Zootaxa 5255 (1) on page 369, DOI: 10.11646/zootaxa.5255.1.29, http://zenodo.org/record/7745023
Particlization with local event-by-event conservation laws
Creators: name: Oliinychenko, Dmytro
name: Koch, Volker
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We present a sampling method for the transition from relativistic hydrodynamics to particle transport, commonly referred to as particlization, which preserves the local event-by-event conservation of energy, momentum, baryon number, strangeness, and electric charge. The proposed method is essential for studying fluctuations and correlations by means of stochastic hydrodynamics. It is also useful for studying small systems. The method is based on Metropolis sampling applied to particles within distinct patches of the hypersurface, where hydrodynamics and kinetic evolutions are matched.
description: 4 pages, 1 figure
Evaluation of chronic cigarette smoke exposure in human bronchial epithelial cultures
Creators: name: Randell, S.H
name: Ghosh, A
name: Tarran, R
name: Manzo, N.D
name: Tyrrell, J
Publisher: name: John Wiley and Sons Ltd
Year: 2023

description: Cigarette smoke (CS) exposure induces both cytotoxicity and inflammation, and often causes COPD, a growing cause of morbidity and mortality. CS also inhibits the CFTR Cl- channel, leading to airway surface liquid dehydration, which is predicated to impair clearance of inhaled pathogens and toxicants. Numerous in vitro studies have been performed that utilize acute (≤24 h) CS exposures. However, CS exposure is typically chronic. We evaluated the feasibility of using British-American Tobacco (BAT)-designed CS exposure chambers for chronically exposing human bronchial epithelial cultures (HBECs) to CS. HBECs are polarized and contain mucosal and serosal sides. In vivo, inhaled CS interacts with mucosal membranes, and BAT chambers are designed to direct CS to HBEC mucosal surfaces while keeping CS away from serosal surfaces via a perfusion system. We found that serosal perfusion was absolutely required to maintain HBEC viability over time following chronic CS exposure. Indeed, with this system, we found that CS increased inflammation and mucin levels, while decreasing CFTR function. Without this serosal perfusion, CS was extremely toxic within 24 h. We therefore propose that 5- and 10-day CS exposures with serosal perfusion are suitable for measuring chronic CS exposure and can be used for monitoring new and emerging tobacco products.
Development of a Calibration Satellite for a CMB Telescope Flying in Formation about L2 Libration Point
Creators: name: BERMEJO-BALLESTEROS, Juan
name: GARCIA-GONZALEZ, Sergio
name: CUBAS, Javier
name: REINARES, Francisco Javier Casas
name: GONZALEZ, Enrique Martinez
Publisher: name: Proceedings of the 8th European Conference for Aeronautics and Space Sciences. Madrid, Spain, 1-4 july 2019
Year: 2019
Subjects: AEROSPACE SYSTEMS
FORMATION FLIGHT

description: The new generation of cosmic microwave background (CMB) telescopes have reached unprecedented levels of sensitivity. These telescopes measure several cosmological parameters with different levels of accuracy. In particular, considerable effort has been made to measure the B-mode polarization, which is related to the inflationary process of the universe. The power spectrum of this signal is about four orders of magnitude fainter than the CMB temperature power spectrum. Due to the signal weakness, the instruments must be subjected to calibration processes before and after launching. Additionally, data from the same sky area is gathered repeatedly to mitigate during data analysis the systematic errors induced by instruments. Celestial sources are often used as an external reference for calibration after launch, but these sources are not perfectly characterized. In this paper we study the concept of using a calibration satellite (CalSat) flying in formation with a CMB telescope in an orbit located at the second Lagrange point (L2). The CalSat is conceived as a micro satellite (10-100 kg) and serves as a perfectly known source of a reference signal to reduce the polarization angle measurement uncertainty. According to the scanning law followed by the telescope, the influence of the relative position between the spacecrafts in the calibration process is studied. The relative motion of the spacecrafts is considered with a simplified dynamic model. Based on the mission requirements, the different subsystems are sized and a preliminary design to evaluate the feasibility is obtained. The design has been carried out under the principle of reducing at minimum the impact on the telescope architecture. It would require to be launched along with the telescope to reach L2 at the same time and being able to communicate with the telescope. This new calibration element could have a huge impact on the performance of this kind of missions, providing a significant improvement in the measurements accuracy without requiring new and costly technological developments.
Additional file 1 of The efficacy of pregabalin for pain control after thoracic surgery: a meta-analysis
Creators: name: Zhang, Li
name: Zhang, Hong
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Cancer
subject: Science Policy

description: Supplementary Material 1
Colombian Foreign Policy Mutations
Creators: name: Sánchez, Fabio
name: Mejía, Santiago
Publisher: name: figshare
Year: 2019
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Colombian Foreign Policy has suffered varied mutations: since Panama’s lost in 1903 (the most value geostrategic point), until the loss of a Caribbean sea portion against Nicaragua under The Hague's ruling (2012). Historically the country has not created a state’s foreign policy, product of an irregular foreign service with a not strategic projection of the national interest. Domestic factors like the internal conflict and the war on drugs has complicated the international projection of the country. Despite the last, we find some positive diplomatic actions in the multilateral system like in the OAS, the Panamerican Operation and the Contadora´s Group amon others.