cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Adolescents, parents and physicians: a comparison of perspectives on type 1 diabetes self-care.
Creators: name: Palladino, Dianne K.
name: Helgeson, Vicki
Publisher: name: Carnegie Mellon University
Year: 2013
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: OBJECTIVE: No research to date has compared the beliefs of adolescents, parents and physicians with respect to type 1 diabetes mellitus self-care perceptions and barriers. This study examined how adolescents with type 1 diabetes, their parents and physicians perceive 4 key diabetes self-care behaviours (testing blood glucose, taking insulin, exercise and diet) and what influences those behaviours. METHOD: Forty-eight adolescent/parent dyads and 21 pediatric endocrinologists rated importance, difficulty and proficiency for 4 self-care behaviours, and provided up to 5 perceived influences on these behaviours. We compared adolescents to parents and families to physicians. RESULTS: Groups rated all self-care behaviours as important, with taking insulin as most important. Families rated behaviours as relatively easy compared to physicians. All groups agreed that diet was both the most difficult self-care behaviour and the behaviour at which adolescents were least proficient. Although families rated teens as proficient overall, physicians disagreed. Adolescent and parent perception of diet difficulty was related to poorer glycemic control, and blood glucose testing and insulin administration proficiency were linked to better glycemic control. Compared to other groups, teens were especially likely to mention internal and hindering influences, and more likely to mention other people as negative influences. CONCLUSIONS: Although all groups agreed that all self-care behaviours are important, there are key areas of discrepancy in perceptions, particularly between families and physicians. Further research should connect the beliefs examined in this study to actual self-care behaviours.
Weisfeiler-Lehman goes dynamic: An analysis of the expressive power of Graph Neural Networks for attributed and dynamic graphs
Creators: name: Beddar-Wiesing, Silvia
name: D’Inverno, Giuseppe Alessio
name: Graziani, Caterina
name: Lachi, Veronica
name: Moallemy-Oureh, Alice
name: Scarselli, Franco
name: Thomas, Josephine Maria
Publisher: name: Universität Kassel
Year: 2024
Subjects: subject: Graph Neural Network
subject: Dynamic graphs
subject: GNN expressivity
subject: Unfolding trees
subject: Weisfeiler-Lehman test
subject: 004
subject: 600
subject: Graph
subject: Algorithmus
subject: Neuronales Netz

description: Gefördert im Rahmen des Projekts DEAL
title: ADCO, Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Cart. 172 (11 H 69), 115 folios, f. 0112
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Archives départementales de la Côte-d'Or, Cart. 172 (11 H 69), 115 folios, f. 0112, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Archives départementales de la Côte-d'Or, Cart. 172 (11 H 69), 115 folios, f. 0112, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Adaptive self-regulation of unattainable goals: goal disengagement, goal reengagement, and subjective well-being.
Creators: name: Wrosch, Carsten
name: Scheier, Michael
name: Miller, Gregory
name: Schulz, Richard
name: Carver, Charles S.
Publisher: name: Carnegie Mellon University
Year: 2003
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Three studies examined associations between goal disengagement, goal reengagement, and subjective well-being. In Study 1, 115 undergraduates reported on the extent to which they were able to abandon unattainable goals and reengage their efforts in alternative goals. Study 2 examined the importance of goal disengagement and goal reengagement in groups of young adults and older adults (N = 120). In Study 3, a sample of parents of children with cancer and parents of medically healthy children was examined (N = 45). The findings confirmed that goal disengagement and goal reengagement can be associated with ratings of high subjective well-being. In addition, the results showed that goal disengagement and goal reengagement can have interactive effects on subjective well-being. The importance of the findings for effective self-regulation and successful development are discussed.
title: Statek Tezeusza – AR / XR a Ochrona Zabytków Architektury
title: The Ship of Theseus – AR / XR and the Protection of Architectural Heritage
titleType: AlternativeTitle
Creators: name: Gladden-Obidzinska, Bogna J.
Publisher: name: Zenodo
Year: 2025

description: The presentation "Statek Tezeusza – AR / XR a Ochrona Zabytków Architektury" explores the challenges and paradigms of architectural heritage conservation. It discusses various international legal frameworks and conventions that form the basis of heritage protection.

The central theme revolves around the "Ship of Theseus" paradox, questioning the identity of heritage objects when conservation involves either strict preservation or material replacement. Three paradigms are examined: (1) traditional conservation and restoration, (2) revitalization and re-creation, and (3) community-based memory preservation.

The presentation also highlights the role of AR/VR technologies in heritage protection, questioning whether they serve as preservation tools or merely as documentation methods. It raises concerns about democratization, accessibility, and commercialization of digital heritage.
Optical recombination of biexcitons in semiconductors
Creators: name: Bauer, M.
name: Keeling, J.
name: Parish, M. M.
name: Rios, P. Lopez
name: Littlewood, P. B.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We calculate the photoluminescence spectrum and lifetime of a biexciton in a semiconductor using Fermi's golden rule. Our biexciton wavefunction is obtained using a Quantum Monte Carlo calculation. We consider a recombination process where one of the excitons within the biexciton annihilates. For hole masses greater than or equal to the electron mass, we find that the surviving exciton is most likely to populate the ground state. We also investigate how the confinement of excitons in a quantum dot would modify the lifetime in the limit of a large quantum dot where confinement principally affects the centre of mass wavefunction. The lifetimes we obtain are in reasonable agreement with experimental values. Our calculation can be used as a benchmark for comparison with approximate methods.
description: 6 pages, 2 figures
Students' acceptance of case-based blended learning in mandatory interdisciplinary lectures for clinical medicine and veterinary public health
Creators: name: Duckwitz, Veronica
name: Vogt, Lena
name: Hautzinger, Claudia
name: Bartel, Alexander
name: Haase, Sebastian
name: Wiegard, Mechthild
name: Doherr, Marcus G.
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: blended learning
subject: case-based learning
subject: interdisciplinary lectures
subject: veterinary curriculum
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: Background In German veterinary education interdisciplinary lectures (ILs) are an important and mandatory part of the curriculum as their merging character builds a useful preparation for the future profession as a veterinarian. These lectures should enable students to work on practically-relevant and interdisciplinary cases, which should ideally be defined jointly by lecturers from different disciplines. Methods In order to give students the opportunity to work on these cases and at the same time have contact with their lecturers and fellow students, the Faculty of Veterinary Medicine, Freie Universität Berlin, has converted its former in-class ILs (face-to-face delivery format) into a blended learning format. The mandatory lectures comprise 196 curricular hours and are delivered over the course of three semesters within the veterinary curriculum. The new concept was developed over a period of three academic years and extensively evaluated (old-new-comparison) with regard to its acceptance and compliance with national requirements for interdisciplinary teaching. Results A total of 306 students were asked to evaluate different aspects of the newly implemented format. Overall, more than 79% of the students attending the newly implemented blended learning format responded positively, and the evaluation showed a significant improvement of learning motivation and acceptance when compared to the traditional teaching format. Conclusion The results indicated that blended learning is a suitable option for teaching mandatory ILs in clinical medicine and veterinary public health.
Localized Oscillatory Dissipation in Magnetopause Reconnection
Creators: name: Burch, J. L.
name: Ergun, R. E.
name: Cassak, P. A.
name: Webster, J. M.
name: Torbert, R. B.
name: Giles, B. L.
name: Dorelli, J. C.
name: Rager, A. C.
name: Hwang, K. -J.
name: Phan, T. D.
name: Genestreti, K. J.
name: Allen, R. C.
name: Chen, L. -J.
name: Wang, S.
name: Gershman, D.
name: Contel, O. Le
name: Russell, C. T.
name: Strangeway, R. J.
name: Wilder, F. D.
name: Graham, D. B.
name: Hesse, M.
name: Drake, J. F.
name: Swisdak, M.
name: Price, L. M.
name: Shay, M. A.
name: Lindqvist, P. -A.
name: Pollock, C. J.
name: Denton, R. E.
name: Newman, D. L.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Space Physics (physics.space-ph)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Data from the NASA Magnetospheric Multiscale (MMS) mission are used to investigate asymmetric magnetic reconnection at the dayside boundary between the Earth's magnetosphere and the solar wind (the magnetopause). High-resolution measurements of plasmas, electric and magnetic fields, and waves are used to identify highly localized (~15 electron Debye lengths) standing wave structures with large electric-field amplitudes (up to 100 mV/m). These wave structures are associated with spatially oscillatory dissipation, which appears as alternatingly positive and negative values of J dot E (dissipation). For small guide magnetic fields the wave structures occur in the electron stagnation region at the magnetosphere edge of the EDR. For larger guide fields the structures also occur near the reconnection x-line. This difference is explained in terms of channels for the out-of-plane current (agyrotropic electrons at the stagnation point and guide-field-aligned electrons at the x-line).
Additional file 9 of Identification and validation of a hypoxia-related prognostic and immune microenvironment signature in bladder cancer
Creators: name: Sun, Xianchao
name: Zhou, Zhen
name: Zhang, Ying
name: Wang, Jinyou
name: Zhao, Xiaofeng
name: Jin, Liang
name: Zhai, Tingshuai
name: Liu, Xiang
name: Zhang, Jiaxin
name: Mei, Wangli
name: Zhang, Bihui
name: Luo, Ming
name: Yao, Xudong
name: Ye, Lin
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer

description: Additional file 9: Table S3. Clinical characteristics of 45 bladder cancer patients.
title: Επιμύδιο, τζινσενγκ, τζίντζερ, γκίνγκο μπιλόμπα: χημική σύσταση και βιολογική δράση
title: Epimedium, ginseng, ginger, gingko biloba: chemical composition and biological activity
titleType: AlternativeTitle
Creators: name: Χατζή, Αθηνά
name: Θεοχάρης, Θεόδωρος
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2021
Subjects: Επιμύδιο
Τζινσενγκ
Τζίντζερ
Γκίνγκο μπιλόμπα
Χημική σύσταση
Βιολογική δράση

description: Η παρούσα εργασία αναφέρεται στη χημική σύσταση και βιολογική δράση των βοτάνων: επιμύδιο, τζινσενγκ, τζίντζερ και γκίνγκο μπιλόμπα
Data-driven wavelet-Fisz methodology for nonparametric function estimation
Creators: name: Fryzlewicz, Piotr
Publisher: name: arXiv
Year: 2007
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics
subject: 62G08 (Primary) 62G05, 62G20 (Secondary)

description: We propose a wavelet-based technique for the nonparametric estimation of functions contaminated with noise whose mean and variance are linked via a possibly unknown variance function. Our method, termed the data-driven wavelet-Fisz technique, consists of estimating the variance function via a Nadaraya-Watson estimator, and then performing a wavelet thresholding procedure which uses the estimated variance function and local means of the data to set the thresholds at a suitable level. We demonstrate the mean-square near-optimality of our wavelet estimator over the usual range of Besov classes. To achieve this, we establish an exponential inequality for the Nadaraya-Watson variance function estimator. We discuss various implementation issues concerning our wavelet estimator, and demonstrate its good practical performance. We also show how it leads to a new wavelet-domain data-driven variance-stabilising transform. Our estimator can be applied to a variety of problems, including the estimation of volatilities, spectral densities and Poisson intensities, as well as to a range of problems in which the distribution of the noise is unknown.
description: Published in at http://dx.doi.org/10.1214/07-EJS139 the Electronic Journal of Statistics (http://www.i-journals.org/ejs/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Additional file 7 of Identification and validation of a hypoxia-related prognostic and immune microenvironment signature in bladder cancer
Creators: name: Sun, Xianchao
name: Zhou, Zhen
name: Zhang, Ying
name: Wang, Jinyou
name: Zhao, Xiaofeng
name: Jin, Liang
name: Zhai, Tingshuai
name: Liu, Xiang
name: Zhang, Jiaxin
name: Mei, Wangli
name: Zhang, Bihui
name: Luo, Ming
name: Yao, Xudong
name: Ye, Lin
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer

description: Additional file 7: Table S1. Clinical characteristics of bladder cancer patients from TCGA cohort.
A Novel Protocol for Network-Controlled Metasurfaces
Creators: name: Tsioliaridou, Angeliki
name: Liaskos, Christos
name: Pitsillides, Andreas
name: Ioannidis, Sotiris
Publisher: name: arXiv
Year: 2018
Subjects: subject: Emerging Technologies (cs.ET)
subject: FOS: Computer and information sciences

description: A recently proposed class of materials, called software-defined metamaterials, can change their electromagnetic behavior on demand, utilizing a nanonetwork embedded in their structure. The present work focuses on 2D metamaterials, known as metasurfaces, and their electromagnetically programmable counterparts, the HyperSurfaces. The particular focus of the study is to propose a nanonetworking protocol that can support the intended macroscopic functionality of a HyperSurface, such as sensing and reacting to impinging waves in a customizable manner. The novel protocol is derived analytically, using the Lyapunov drift minimization approach, taking into account nano-node energy, communication latency and complexity concerns. The proposed scheme is evaluated via simulations, covering both the macroscopic HyperSurface functionality and the microscopic, nanonetwork behavior.
Borophene hydride: a stiff 2D material with high thermal conductivity and attractive optical and electronic properties
Creators: name: Mortazavi, Bohayra
name: Makaremi, Meysam
name: Shahrokhi, Masoud
name: Raeisi, Mostafa
name: Singh, Chandra Veer
name: Rabczuk, Timon
name: Pereira, Luiz Felipe C
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Two-dimensional (2D) structures of boron atoms so called borophene, have recently attracted remarkable attention. In a latest exciting experimental study, a hydrogenated borophene structure was realized. Motivated by this success, we conducted extensive first-principles calculations to explore the mechanical, thermal conduction, electronic and optical responses of borophene hydride. The mechanical response of borophene hydride was found to be anisotropic in which it can yield an elastic modulus of 131 N/m and a high tensile strength of 19.9 N/m along the armchair direction. Notably, it was shown that by applying mechanical loading the metallic electronic character of borophene hydride can be altered to direct band-gap semiconducting, very appealing for the application in nanoelectronics. The absorption edge of the imaginary part of the dielectric function was found to occur in the visible range of light for parallel polarization. Finally, it was estimated that this novel 2D structure at the room temperature can exhibit high thermal conductivities of 335 W/mK and 293 W/mK along zigzag and armchair directions, respectively. Our study confirms that borophene hydride benefits an outstanding combination of interesting mechanical, electronic, optical and thermal conduction properties, promising for the design of novel nanodevices.
Active control of locomotion facilitates nonvisual navigation
Creators: name: Philbeck, John W.
name: Klatzky, Roberta
name: Behrmann, Marlene
name: Loomis, Jack M.
name: Goodridge, Jeremy
Publisher: name: Carnegie Mellon University
Year: 2001
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: In some navigation tasks, participants are more accurate if they view the environment beforehand. To characterize the benefits associated with visual previews, 32 blindfolded participants were guided along simple paths and asked to walk unassisted to a specified destination (e.g., the origin). Paths were completed without vision, with or without a visual preview of the environment. Previews did not necessarily improve nonvisual navigation. When previewed landmarks stood near the origin or at off-path locations, they provided little benefit; by contrast, when they specified intermediate destinations (thereby increasing the degree of active control), performance was greatly enhanced. The results suggest that the benefit of a visual preview stems from the information it supplies for actively controlled locomotion. Accuracy in reaching the final destination, however, is strongly contingent upon the destination's location during the preview.
Arquitetura do Computador Quântico
Creators: name: de Azevedo Camargo, Gabriel
name: Vinícius Matos da Silva, Hugo
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Quântico
subject: Quantum computers
subject: Computer and information sciences
subject: FOS: Computer and information sciences

description: A arquitetura presente em computadores quânticos, inovadora e ao mesmo tempo muito promissora, computadores que podem realizar cálculos de dificuldades muito altas, que antes não poderiam ser executadas em computadores normais, além de que permite o estudo mais aprofundade sobre propriedades da física quântica. O intuíto desse artigo é exemplificar como essa arquitetura é composta, como utilizar e exemplificar algoritmos que possam ser usados.
Targeted use of transcranial direct current stimulation for cognitive modulation after traumatic brain injury: A neurophysiological and behavioural investigation
Creators: name: Li, Lucia Mengxi
Publisher: name: Imperial College London
Year: 2018

description: Cognitive control requires the coordinated function of large-scale brain networks. The interactions between the Salience Network (SN) and Default Mode Network (DMN) are thought to be particularly important. Traumatic Brain Injury (TBI) commonly leads to cognitive dysfunction, and is also associated with abnormal SN and DMN function and connectivity. Transcranial direct current stimulation (TDCS) has been extensively studied as a tool for cognitive enhancement. However, there is high variability in the reported behavioural benefits of TDCS, and little understanding of how it affects the brain networks mediating cognitive control. The overarching aim of this thesis is to investigate the potential of TDCS for improving cognitive dysfunction after TBI. Chapter 3 investigates whether TDCS has the potential to modulate cognitive function in healthy controls, using bi-parietal TDCS in cognitive tasks with strong hemispheric lateralisation. In Chapters 4 and 5, I acquire functional MRI (fMRI) concurrently to applying TDCS to the SN, in order to assess the effects of TDCS on both brain networks and cognitive control (assessed using a response inhibition task, the Stop Signal Task). I also investigate whether structural connectivity of cognitive networks influences the response to TDCS. In Chapters 7-9, I apply this TDCS strategy to a cohort of chronic TBI patients. Chapter 7 assesses whether single-session SN TDCS improves response inhibition, whether white matter damage influences any response to stimulation and whether TDCS can improve abnormal network function. Chapter 8 presents a targeted analysis of the effects of multi-day anodal TDCS treatment on response inhibition and brain network function. Chapter 9 presents the effect of multi-day anodal TDCS treatment on a wider range of cognitive measures. In summary, this thesis investigates the proof-of-principle that TDCS can be used for cognitive rehabilitation after TBI. Through a progressive set of experiments in healthy and TBI participants, I assess the effects on cognitive function as well as on key cognitive control networks, and explore factors which may explain variability in responses to TDCS. The work presented within this thesis supports a multimodal approach to conducting TDCS studies in the cognitive field, with an emphasis on concurrent behavioural and neurobiological assessment, as well as highlighting the importance of directly addressing patient heterogeneity in TBI interventional studies.
Approach to accurately measuring the speed of optical precursors
Creators: name: Li, Chuan-Feng
name: Zhou, Zong-Quan
name: Jeong, Heejeong
name: Guo, Guang-Can
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Precursors can serve as a bound on the speed of information with dispersive medium. We propose a method to identify the speed of optical precursors using polarization-based interference in a solid-state device, which can bound the accuracy of the precursors' speed to less than $10^{-4}$ with conventional experimental conditions. Our proposal may have important implications for optical communications and fast information processing.
description: 4 pages, 4 figures
High-Reflection Coatings for Gravitational-Wave Detectors: State of The Art and Future Developments
Creators: name: Amato, Alex
name: Cagnoli, Gianpietro
name: Canepa, Maurizio
name: Coillet, Elodie
name: Degallaix, Jerome
name: Dolique, Vincent
name: Forest, Daniele
name: Granata, Massimo
name: Martinez, Valérie
name: Michel, Christophe
name: Pinard, Laurent
name: Sassolas, Benoit
name: Teillon, Julien
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: We report on the optical, mechanical and structural characterization of the sputtered coating materials of Advanced LIGO, Advanced Virgo and KAGRA gravitational-waves detectors. We present the latest results of our research program aiming at decreasing coating thermal noise through doping, optimization of deposition parameters and post-deposition annealing. Finally, we propose sputtered Si3N4 as a candidate material for the mirrors of future detectors.
title: ADCO, Grènetier de Cîteaux : comptes (1497-1504) (11 H 1172), f. 00187
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172), f. 00187, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
Synchronization of phase oscillators with heterogeneous coupling: A solvable case
Creators: name: Paissan, Gabriel H.
name: Zanette, Damian H.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: We consider an extension of Kuramoto's model of coupled phase oscillators where oscillator pairs interact with different strengths. When the coupling coefficient of each pair can be separated into two different factors, each one associated to an oscillator, Kuramoto's theory for the transition to synchronization can be explicitly generalized, and the effects of coupling heterogeneity on synchronized states can be analytically studied. The two factors are respectively interpreted as the weight of the contribution of each oscillator to the mean field, and the coupling of each oscillator to that field. We explicitly analyze the effects of correlations between those weights and couplings, and show that synchronization can be completely inhibited when they are strongly anti-correlated. Numerical results validate the theory, but suggest that finite-size effect are relevant to the collective dynamics close to the synchronization transition, where oscillators become entrained in synchronized frequency clusters.
description: To appear in Physica D
title: Les tumeurs osseuses malignes du rachis pediatrique
Creators: name: M. Rizkallah
name: A-J. Bizdikian
name: I. Ghanem
Publisher: name: Société Française d’Orthopédie Pédiatrique (SOFOP)
Year: 2024
Subjects: subject: Tumeurs
subject: Osseuses
subject: Rachis

description: Dans les pays développés, le cancer est la deuxième cause de décès dans la population pédiatrique [1,2]. Dans cette population, la majorité des cancers surviennent au dépends du système lympho-reticulaire et du système nerveux central[1,2]. Les tumeurs malignes affectant le système musculosquelettique, et particulièrement le squelette axial, sont peu fréquentes chez les enfants et représentent 1% de la totalité des tumeurs malignes[3]. Néanmoins, le diagnostic des tumeurs osseuses malignes spinales de l’enfant soulève un défi important au praticien qui doit reconnaitre cette pathologie en se basant sur des symptômes subtiles et atypiques. La prise en charge de ces tumeurs malignes a connu un progrès significatif au cours de ces dernières décennies avec un impact favorable sur le pronostic, faisant du diagnostic précoce et de la référence aux centres spécialisés un atout pour améliorer la survie des patients [3,4].
Genomics and metabonomics in severe alcoholic hepatitis
Creators: name: Atkinson, Stephen
Publisher: name: Imperial College London
Year: 2018

description: Severe alcoholic hepatitis is a florid presentation of alcohol-related liver disease and is associated with very high short-term mortality, in excess of 20% within 28 days. Severe alcoholic hepatitis occurs in a minority of patients who develop alcohol-related liver disease. A combination of genetic and environmental factors is likely to predispose to severe alcoholic hepatitis. To date the clinical phenotype has not been extensively examined in candidate gene studies and has been the subject of a single, small genome-wide association study. A genome-wide association study of severe alcoholic hepatitis identified two loci potentially associated with the risk of developing severe alcoholic hepatitis: i) A strong association with PNPLA3, a well-recognised risk locus for alcohol-related liver disease, and ii) a novel but weaker association with SLC38A4, an amino acid transporter. The primary genetic variant at each locus was evaluated to determine whether there was an influence on disease phenotype or outcome. The primary variant in PNPLA3, rs738409, is a missense variant. Analyses indicated a deleterious effect of homozygosity on medium-term survival in addition to more severe disease on baseline histology and a slower recovery in liver function over the short-term period; consistent with established literature in alcohol-related cirrhosis. In contrast the primary variant in SLC38A4, rs11183620, is intronic with no clear evidence for an effect on gene expression or function. Analyses did not indicate an influence on histology, clinical phenotypes or outcomes. In light of the locus’ novelty further work was undertaken to determine any potential contribution to disease pathogenesis. SLC38A4 was down-regulated in whole liver tissue in severe alcoholic hepatitis. Experiments with cell lines in culture suggested the pro-inflammatory cytokine IL-1 as a potential driver. SLC38A4 knockdown resulted in upregulation of some cellular responses associated with nutrient deprivation. There was no influence of the variant on serum amino acid profiles. The functional significance of SLC38A4 down-regulation remains the subject of ongoing work.
The development of a platform to manipulate cardiomyocyte structure and function
Creators: name: Kit-Anan, Worrapong
Publisher: name: Imperial College London
Year: 2019

description: Cardiac tissue engineering to replace damaged areas of the postmitotic heart is still presented with significant challenges, due to the complex and dynamic interplay of electrical, mechanical and biochemical signals involved in the myocardium. The advancement of regenerative approaches is focussed on understanding the underlying regulatory mechanisms involved throughout cardiac development. However, current knowledge of how biophysical cues in the stem cell niche can modulate cell behaviour is limited. Firstly, polyacrylamide-co-acrylic acid was used as an in vitro stiffness-tuneable platform to test the effect of substrate mechanics on human induced pluripotent stem cell (hiPSC) differentiation into cardiomyocytes (CM). The results showed that the optimum differentiation efficiency level peaked at the embryonic-like stiffness of 560 Pa, with increased upregulation of cardiac genes. Functionally, hiPSC-CMs showed a biphasic relationship with a faster calcium transient and higher force generation at cardiac physiological stiffness. Next, shape was incorporated into the experimental design via CardioArray, a custom-built platform which mimics both the stiffness and shape of an adult human CM. This system can accommodate individual hiPSC-CMs to adopt the 3D geometry of an adult CM, while at the same time providing the relevant stiffness cues from the underlying substrate. The results highlighted the specific contribution of stiffness and 3D shape to α-sarcomeric structure, cell membrane stiffness, single cell gene expression and intracellular calcium cycling. Finally, the electrical microenvironment was investigated as a third infleuncing factor on hiPSC-CM development. A hybrid conductive polyaniline-Scl2 scaffold was fabricated, showing long term electronic stability and no cell toxicity when interfaced with electrosensitive hiPSC-CMs. This could provide electromechanical stability in model studies. Improvement of conduction velocity was observed in an in vitro myocardial slice model. As a whole, this thesis demonstrates the differential effects of substrate mechanics on hiPSC cardiac differentiation, providing a novel crucial understanding of how biophysical cues modulate the stem cell niche during differentiation and in vitro culture.
Massless D-strings and moduli stabilization in type I cosmology
Creators: name: Estes, John
name: Liu, Lihui
name: Partouche, Herve
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider the cosmological evolution induced by the free energy F of a gas of maximally supersymmetric heterotic strings at finite temperature and weak coupling in dimension D>=4. We show that F, which plays the role of an effective potential, has minima associated to enhanced gauge symmetries, where all internal moduli can be attracted and dynamically stabilized. Using the fact that the heterotic/type I S-duality remains valid at finite temperature and can be applied at each instant of a quasi-static evolution, we find in the dual type I cosmology that all internal NS-NS and RR moduli in the closed string sector and the Wilson lines in the open string sector can be stabilized. For the special case of D=6, the internal volume modulus remains a flat direction, while the dilaton is stabilized. An essential role is played by light D-string modes wrapping the internal manifold and whose contribution to the free energy cannot be omitted, even when the type I string is at weak coupling. As a result, the order of magnitude of the internal radii expectation values on the type I side is (lambda_I alpha')^{1/2}, where lambda_I is the ten-dimensional string coupling. The non-perturbative corrections to the type I free energy can alternatively be described as effects of "thermal E1-instantons", whose worldsheets wrap the compact Euclidean time cycle.
description: 39 pages, 1 figure
title: Tumeurs osseuses bénignes du rachis
Creators: name: D. Fron
Publisher: name: Société Française d’Orthopédie Pédiatrique (SOFOP)
Year: 2024
Subjects: subject: Tumeurs
subject: Osseuses
subject: Rachis

description: Les tumeurs osseuses du rachis sont rares chez l’enfant et il faut savoir y penser devant des douleurs parfois banales ou en cas de signes neurologiques.
Leur diagnostic et leur traitement posent des problèmes souvent difficiles.
Action, Emotion, and Personality: Emerging Conceptual Integration
Creators: name: Carver, Charles S.
name: Sutton, Steven K.
name: Scheier, Michael
Publisher: name: Carnegie Mellon University
Year: 2000
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Several literatures converge on the idea that approach and positive affect related to goal pursuit are managed by one self-regulatory system and that avoidance (or withdrawal) and negative affect related to threats are managed by a second self-regulatory system. After briefly reviewing these literatures, the authors consider the relation of these themes to the broader domain of personality. In particular, they map individual differences in the responsivity of the approach system onto the personality dimension of extraversion and map individual differences in the responsivity of the withdrawal system onto the dimension of neuroticism. This mapping requires a slight refocusing of current conceptions of extraversion and neuroticism. However, such a refocusing brings a gain as well as a cost: In particular, it would embed these dimensions more explicitly in a process-oriented conceptualization of action control.
Development of a CHO cell-free protein synthesis platform for accelerated antibody screening
Creators: name: Heide, Chiara Josephine
Publisher: name: Imperial College London
Year: 2020

description: Over 80% of therapeutic monoclonal antibody (mAb) products are expressed in Chinese Hamster Ovary (CHO) cells. While cell-based expression platforms are traditionally used for the exploration of novel mAb therapeutics in the discovery phase, cell-based technologies remain particularly time- and resource intensive for mAb screening. To circumvent these shortcomings, cell-free protein synthesis (CFPS) platforms have emerged as versatile alternative allowing for rapid and flexible production of therapeutic proteins. In contrast to in vivo systems, CFPS platforms do not require intact host cells, which make them completely independent of host cell metabolism in determining product yield and quality. Although the open-production system bears several advantages over the traditional cell-based platforms, CFPS platforms still face limitations such as low product yields, challenges with post-translational modifications (PTMs), and poor cost efficiency of CFPS. It is therefore of great interest, to develop a simple, more cost-efficient and active CHO CFPS platform for accelerated screening of therapeutic mAbs. This work addresses the current limitations by developing a cell-free protein synthesis platform using CHO extracts for the rapid production and evaluation of industrially relevant mAbs. This study is divided into three main parts: 1) Development of a CHO CFPS system, 2) Yield optimization of CHO CFPS, 3) Production and screening of therapeutic mAbs. Our platform was able to express and characterise four functional mAbs in the supernatant fraction of 25 μl coupled batch reactions including two low in vivo expressers and the blockbuster drug Trastuzumab. Total synthesis yields were increased up to 50-fold by supplementing the system with two accessory proteins, GADD34 and K3L. Using our optimized platform, mAb yields of up to 31.06 μg/ml could be achieved. The trend in cell-free expressed functional mAbs replicated previously reported results from cell-based expression. Based on the success of our platform, we suggest its use for rapid, low-scale antibody expression screening to accelerate molecule selection and development for the biopharmaceutical industry.
Slowly Rotating Charged Gauss-Bonnet Black holes in AdS Spaces
Creators: name: Kim, Hyeong-Chan
name: Cai, Rong-Gen
Publisher: name: arXiv
Year: 2007
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Rotating charged Gauss-Bonnet black hole solutions in higher dimensional ($d >4$), asymptotically anti-de Sitter spacetime are obtained in the small angular momentum limit. The angular momentum, magnetic dipole moment, and the gyromagnetic ratio of the black holes are calculated and it turns out that the Gauss-Bonnet term does not affect to the gyromagnetic ratio.
description: 10 pages, 3 figures
LA VIEJA Y LA NUEVA ÉTICA MÉDICA
Creators: name: Genival Veloso de França
Publisher: name: Zenodo
Year: 2005

description:  Sumario: El autor relaciona la ética médica de antes con la actual y apunta las diversas causas que llevaron a los cambios verificadas, así como sus consecuencias. Apunta también algunas situaciones que advendrán en el futuro alrededor del ejercicio de una medicina predictiva.
Action, Affect, Multitasking, and Layers of Control
Creators: name: Carver, Charles S.
name: Scheier, Michael
Publisher: name: Carnegie Mellon University
Year: 2009
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: This chapter describes aspects of the view we hold on the self-regulation of action and affect. It begins with the idea that two layers of feedback processes manage two different aspects of behavior, operating together, allowing people to juggle multiple tasks and conserve resources. In this way, multiple, simultaneous motivations are transformed into a stream of actions shifting repeatedly from one goal to another.
Risk, ambiguity and quantum decision theory
Creators: name: Franco, Riccardo
Publisher: name: arXiv
Year: 2007
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: In the present article we use the quantum formalism to describe the effects of risk and ambiguity in decision theory. The main idea is that the probabilities in the classic theory of expected utility are estimated probabilities, and thus do not follow the classic laws of probability theory. In particular, we show that it is possible to use consistently the classic expected utility formula, where the probability associated to the events are computed with the equation of quantum interference. Thus we show that the correct utility of a lottery can be simply computed by adding to the classic expected utility a new corrective term, the uncertainty utility, directly connected with the quantum interference term.
description: 1 figure
Microfluidic methods for single cell analysis in clinically relevant samples
Creators: name: Katsanovskaja, Ksenia
Publisher: name: Imperial College London
Year: 2020

description: Single cell protein analysis has the potential to comprehensively profile cellular heterogeneity advancing the understanding of cell function, disease progression and drug development. Although it is a possible contributor to the discovery of novel therapy, the protein mapping on the individual cell basis is complex and poses challenges. For example, cancer is a heterogeneous disease which analysis using conventional bulk methods can potentially conceal a dangerous population like Circulating Tumour Cells (CTCs). Analysis of CTCs can only be reliably attained using single cell technologies. The Microfluidic Affinity Capture (MAC) chip is a tool that was developed in our group to study cellular heterogeneity by measuring protein abundance in single cells. Another problem in analysing cancer cells is the difficulty in obtaining samples in a non-invasive manner. This thesis reports on attempts to obtain, concentrate and analyse CTCs from blood using a composite MAC-based device. The ability to analyse single cells has advantages beyond the potential for analysing heterogeneity. Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous illness that is characterised by a chronic inflammation. Although the immune response in COPD requires investigation, it is complicated by a lack of biomarkers and methods to non-invasively collect samples. The ability to obtain and effectively analyse precious and scarce biomaterial from lungs, is greatly advantageous for both diagnosis and tracking of COPD. Here, we report on a workflow to achieve this using sputum from negative control volunteers and COPD+ patients. Also, we describe the establishment of a novel MAC chip assay targeting FOXO3 protein which is involved in regulation of processes like tumour suppression, inflammation and senescence. Therefore, it has a biomarker potential to monitor and study diseases like cancer and COPD. We developed the protocol to analyse Forkhead box 3 (FOXO3) protein expression in nasal cells from healthy donor samples that were retrieved with a non-invasive tool (NASAM, nasal synthetic absorptive matrix). Nasal cavity is a front line of exposure to inhaled pernicious substances and, it is speculated to reflect anomalous bioprocesses in lungs preceding respiratory disease development and progression. This study provides the first-time quantification of FOXO3 protein in single cells from nasal samples. This work shows the analytical capacity of the MAC chip to study cellular heterogeneity and quantify important biomarkers in single cells of clinically relevant material.
Additional file 2 of Verification of EZH2 as a druggable target in metastatic uveal melanoma
Creators: name: Jin, Bei
name: Zhang, Ping
name: Zou, Hailin
name: Ye, Huijing
name: Wang, Yun
name: Zhang, Jing
name: Yang, Huasheng
name: Pan, Jingxuan
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2 Supplementary Figure S1. The prognostic factors of EZH2, BAP1, and Class 1 vs 2 GEP in the correlation of UM overall survival and metastasis-free survival in published database. Supplementary Figure S2. Verification of EZH2 overexpression and knockdown in UM cells. Supplementary Figure S3. Pharmacologic inhibition of EZH2 induces G2/M phase arrest and activation of p53. Supplementary Figure S4. GSK126 induces apoptosis in UM via triggering intrinsic pathway. Supplementary Figure S5. EZH2 confers maintenance of cancer stem cells (CSCs) in uveal melanoma involing Wnt/β-catenin signaling. Supplementary Figure S6. EZH2 confers maintenance of cancer stem cells via suppressing miR-29b2/c gene transcription in uveal melanoma. Supplementary Figure S7. EZH2 mediates motility of UM cells via RhoGDIγ-Rac1 axis. Supplemetary Figure S8. EZH2 facilities liver metastasis of UM in NOG mice. Supplementary Figure S9. The expression of BAP1 and EZH2 is parallel in UM cells.
Acquisition of Long-Term Visual Representations: Psychological and Neural Mechanisms
Creators: name: Behrmann, Marlene
name: Geng, Joy J
name: Baker, Chris
Publisher: name: Carnegie Mellon University
Year: 2005
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: How do we so rapidly achieve an organized, coherent visual percept of our superficially chaotic world? One way of reducing the complexity of the input is to take advantage of the statistical regularities and regular co-occurrences between aspects of objects and between objects and their spatial locations. In this chapter, converging data obtained from normal and brain-damaged individuals, as well as from single unit recording studies in monkeys, are presented, all of which address the psychological and neural mechanisms associated with statistical learning. The first section deals with learning regularities associated with particular spatial locations, presumably a function of the dorsal ‘where’ stream and data from normal individuals and from patients with hemispatial neglect are presented. The second section reports the findings from human and monkey studies, which show how statistical contingencies of the visual environment are reflected in behavior and how neurons in monkey inferotemporal cortex, the ventral “what” stream, appear to mediate these statistical effects. Taken together, using data from a variety of methodologies, this work attests to the flexibility and robustness of the visual system and sheds light on the way in which perceptual organization operates to convert raw input into long-term visual representations.