cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Data-driven quantification of model-form uncertainty in Reynolds-averaged simulations of wind farms
Creators: name: Eidi, Ali
name: Zehtabiyan-Rezaie, Navid
name: Ghiassi, Reza
name: Yang, Xiang
name: Abkar, Mahdi
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Computational fluid dynamics using the Reynolds-averaged Navier-Stokes (RANS) remains the most cost-effective approach to study wake flows and power losses in wind farms. The underlying assumptions associated with turbulence closures are one of the biggest sources of errors and uncertainties in the model predictions. This work aims to quantify model-form uncertainties in RANS simulations of wind farms at high Reynolds numbers under neutrally stratified conditions by perturbing the Reynolds stress tensor through a data-driven machine-learning technique. To this end, a two-step feature-selection method is applied to determine key features of the model. Then, the extreme gradient boosting algorithm is validated and employed to predict the perturbation amount and direction of the modeled Reynolds stress toward the limiting states of turbulence on the barycentric map. This procedure leads to a more accurate representation of the Reynolds stress anisotropy. The data-driven model is trained on high-fidelity data obtained from large-eddy simulation of a specific wind farm, and it is tested on two other (unseen) wind farms with distinct layouts to analyze its performance in cases with different turbine spacing and partial wake. The results indicate that, unlike the data-free approach in which a uniform and constant perturbation amount is applied to the entire computational domain, the proposed framework yields an optimal estimation of the uncertainty bounds for the RANS-predicted quantities of interest, including the wake velocity, turbulence intensity, and power losses in wind farms.
A Transgenic Zebrafish Model of Signaling Through Toll-Like Receptors
Creators: name: Elsberry, Danielle
Publisher: name: University of Utah
Year: 2014

description: Toll-like receptors (TLRs), members of the innate immune system, recognize distinctive components of pathogens to initiate cellular signaling pathways. These pathways lead to the production of inflammatory proteins such as tumor necrosis factor alpha (TNFα), a cytokine that activates immune cells to fight the infection. When infections disseminate into the bloodstream, TLR-signaling is activated systemically and the excessive release of cytokines, chemokines, and other inflammatory mediators produces a life-threatening condition known as septic shock. The majority of drugs recently developed to treat septic shock were beneficial in animal and in vitro models, but were ineffective in human clinical trials. One possible solution to resolve this disparity is to use the new animal model Danio rerio (zebrafish) whose unique characteristics allow for high-throughput, large-scale screening of chemicals and for exclusive study of the innate immune system. We undertook three different approaches to establish a functioning transgenic zebrafish model that facilitates visualization of TNFα expression as an indicator of TLR signaling and pathologic immune response. The first expression clone contains the human TNFα (hTNFα) enhancer and the enhanced green fluorescent (EGFP) reporter gene under control of the basal carp β-actin promoter. The second expression clone contains all elements of the first clone with the addition of a red fluorescent reporter gene, DsRed, under control of a lens-specific promoter, the Xenopus laevis γ-crystallin iv promoter (Cry), to facilitate preselection of putative transgenic founders. The third expression clone is a modified BAC clone containing the red fluorescent reporter gene tandem-dimer Tomato (tdTomato) fused to the zebrafish TNFα (zTNFα) gene in its genomic context. We successfully introduced the modified BAC clone into the germline of two male zebrafish. To date, one female offspring from an F0 founder has been identified as carrying the BAC transgene. In the future, the F2 embryos from this F1 female will be analyzed for expression of the fluorescent fusion protein under conditions which induce TNFα production. Additionally, future establishment of a homozygous transgenic generation will allow functional studies of TLR signaling during infections and assessment of chemical and genetic modifiers of TNFα induction.
TUBERCULOUS OTITIS MEDIA IN A 32 YEAR OLD ETHIOPIAN WOMAN
Creators: name: Gebreselassie, Feseha
name: Isa, Suleman
name: Asres, Getahun
Publisher: name: Ethiopian Journal of Health and Biomedical Sciences
Year: 2014

description: Otitis media is one of the commonest upper respiratory tract infections particularly in children. The presence of repeated upper respiratory tract infections could indicate the presence of immunecompromization in adults. Even though the etiologies are mostly bacterial species like S.pneumoniae, H.influenzae and M.catarrhalis for acute ones and many more for the chronic presentations, otitis media can be caused by a number of other etiologic agents. Otitis media as a result of M.tuberculosis is a very rare incident in adults. This is a case report of a 32 year old HIV infected woman from northwest Ethiopia who presented with chronic ear discharge. She was treated repeatedly with different antibiotics which did not bring any improvement until the case was incidentally discovered to have been caused by M.tuberculosis.
description: Ethiopian Journal of Health and Biomedical Sciences, Vol. 6 No. 1 (2014): ETHIOPIAN JOURNAL OF HEALTH AND BIOMEDICAL SCIENCES
IC MAGE UMIP - universal model interface for PLAXIS
Creators: name: Taborda, David M G
name: Kontoe, Stavroula
name: Tsiampousi, Aikaterini
Publisher: name: Zenodo
Year: 2022
Subjects: Geotechnical Analysis
Finite Element Analysis
Constitutive Modelling
Geotechnical Engineering

description: Documentation for IC MAGE's Universal Model Interface for PLAXIS. The Universal Model Interface for PLAXIS (UMIP) is a platform designed to facilitate the implementation of constitutive models into PLAXIS. Currently, the only integration scheme available for the constitutive relationship is a Modified Euler substepping scheme with automatic error control.
description: {"references": ["Azeiteiro, R.J.N. (2021) Numerical simulation of liquefaction-related phenomena. PhD Thesis, University of Coimbra, Portugal.", "Dowell, M. and Jarratt, P. (1972). The 'Pegasus' method for computing the root of an equation. BIT Numerical Mathematics, 12 (4), 503\u2013508.", "Hong, P.Y., Pereira, J.M., Cui, Y.J. and Tang, A.M. (2012). Explicit integration of a thermo-mechanical model for clays. Computers and Geotechnics, 46, 13\u201325.", "Potts, D.M. and Gens, A. (1985). A critical assessment of methods of correcting for drift from the yield surface in elasto-plastic finite element analysis. International Journal for Numerical and Analytical Methods in Geomechanics, 9 (2), 149\u2013159.", "Potts, D.M. and Zdravkovic, L. (1999). Finite element analysis in geotechnical engineering. Theory. London, U.K., Thomas Telford Publishing.", "Sloan, S.W. (1987). Substepping schemes for numerical integration of elasto-plastic stress-strain relations. International Journal for Numerical Methods in Engineering, 24 (5), 893\u2013911.", "Sloan, S.W., Abbo, A.J. and Sheng, D. (2001). Refined explicit integration of elastoplastic models with automatic error control. Engineering Computations, 18 (1), 121\u2013194.", "Taborda, D.M.G., Potts, D.M. and Zdravkovi\u0107, L. (2016). On the assessment of energy dissipated through hysteresis in finite element analysis. Computers and Geotechnics, 71, 180\u2013194.", "Taborda, D.M.G and Zdravkovi\u0107, L. (2012). Application of a Hill-Climbing technique to the formulation of a new cyclic nonlinear elastic constitutive model. Computers and Geotechnics, 43, 80-91."]}
Sonnenfleckenzeichnung Nr. 21212.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.10.1962, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1962

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Incidence of postoperative pulmonary complications in a group of smoking patients compared to a group of nonsmoking patients
Creators: name: Mansen, Thomas John
Publisher: name: University of Utah
Year: 2012
Subjects: Postoperative Care
Tobacco
Physiological Effect

description: Forty subjects who had had abdominal surgery under general anesthesia were studied in the postoperative period for incidence of postoperative pulmonary complications.  The group was divided into smokers and non-smokers.  Incidence of postoperative pulmonary complications were determined and compared between the two groups.  The null hypothesis was used in this study and stated:  "There will be no significant difference in the incidence of postoperative pulmonary complications in a group of smokers as compared to a group on non-smoker."  Statistical analysis was done by the Mantel-Haenszel and Fisher-Exact tests at the p > 0.05 significant level.  Subject in each study group were evaluated on the first three consecutive postoperative days at 24 hour intervals.  Evaluation was done in four categories:  temperature, lung sounds, cough, and respiratory rate.  Criteria for evaluation of the subject had been established in each area for each 24 hour interval.  The incidence of postoperative pulmonary complications was based on the number of subjects who did not meet the criteria in each category for each day.  The results of this study allowed for null hypothesis to be accepted for the first day and rejected for the second and third day. Significant differences between the two study group were found in the categories of lung sounds and cough on the second day, and cough on the third day.   Temperature and respiratory rate did not exhibit any significant differences on any of the study days.  Further investigation should be done in this area by identifying preoperative and/or postoperative nursing interventions for smokers designed to decrease the incidence of postoperative pulmonary complications in this group.
Sonnenfleckenzeichnung Nr. 21244.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.12.1962, erstellt von Werner Scheidegger.
Zusätzlich ist vermerkt: Kern-Refraktor
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1962

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Mechanism of HIV entry:  surface stiffnes and steric defense.
Creators: name: Shi, Yu
Publisher: name: University of Utah
Year: 2012
Subjects: HIV (Viruses)
Etiology

description: HIV undergoes a maturation process required for infectivity after leaving the cell.  Significant internal morphological rearrangements occur during the maturation process, converting the immature HIV particle with a thick protein shell into a mature particle with a thin protein shell and a prominent conical core.  In this study, we explored the linkage between virion morphology and mechanical properties during maturation.  Our results showed that the stiffness of HIV drops dramatically during maturation, and that there is a correlation between virion stiffness and entry ability.  We also showed that virion stiffness is mainly regulated by the ENV CT domain.  During HIV entry, HIV Env (gp120/gp41 complex undergoes a series of conformational changes that induce viral and target cell membrane fusion.  Membrane fusion is driven by the formation of gp41 six-helix bundle composed of the N-trimer region surrounded by three helices from the C-peptide region (C-peptides).  Prevention of six-helix bundle formation inhibits membrane fusion and viral entry.  This critical role in entry and its highly conserved sequences make the gp41 N-trimer a key drug target.  Gp41 C-peptides bind the N-trimer and potently inhibit HIV entry by preventing binding of the endogenous C-peptide region.  Extensive efforts have been made to find potent broadly neutralizing Abs against the N-trimer, but without success.  Our lab previously demonstrated that there is a steric block on the viral side of the N-trimer region, which may explain why such Abs are difficult to discover.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 18.12.1962, erstellt von Emilia Tifrea, Observatorium Bukarest
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1962

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Astronomischen Observatorium Bukarest, Solarsektor, Rumänien. Instrument: Zeiss-Refraktor (Öffnung 130mm, f = 1950mm, projiziertes Sonnenbild D = 25cm)
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.11.1962, erstellt von M. Cirsmaru, Observatorium Bukarest
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1962

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Astronomischen Observatorium Bukarest, Solarsektor, Rumänien. Instrument: Zeiss-Refraktor (Öffnung 130mm, f = 1950mm, projiziertes Sonnenbild D = 25cm)
Sonnenfleckenzeichnung Nr. 21185.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.09.1962, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1962

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Ladder of Eckhaus instabilities and parametric conversion in chi(2) microresonators
Creators: name: Puzyrev, D. N.
name: Skryabin, D. V.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Low loss microresonators have revolutionised nonlinear and quantum optics over the past decade. In particular, microresonators with the second order, chi(2), nonlinearity have the advantages of broad spectral tunability and low power frequency conversion. Recent observations have highlighted that the parametric frequency conversion in chi(2) microresonators is accompanied by stepwise changes in the signal and idler frequencies. Therefore, a better understanding of the mechanisms and development of the theory underpinning this behaviour is timely. Here, we report that the stepwise frequency conversion originates from the discrete sequence of the so-called Eckhaus instabilities. After discovering these instabilities in fluid dynamics in the 1960s, they have become a broadly spread interdisciplinary concept. Now, we demonstrate that the Eckhaus mechanism also underpins the ladder-like structure of the frequency tuning curves in chi(2) microresonators.
description: 10 pages, 5 figures
BARDET-BIEDL SYNDROME IN AN ETHIOPIAN: A CASE REPORT
Creators: name: Tsegaw, Asamere
name: Teshome, Tiliksew
Publisher: name: Ethiopian Journal of Health and Biomedical Sciences
Year: 2014

description: Bardet-Biedl syndrome (BBS) is a rare familial and multi-system disorder with an autosomal recessive pattern of inheritance and wide range of clinical variability. Its main manifestations are progressiveretinaldystrophy, renal dysfunction, post-axial polydactyly, central obesity, mental retardation, and hypogonadism. Renal failure is known to be the main cause of death in patients with BBS. Retinal dystrophy and other eye diseases seen in patients with BBS can cause severe visual impairment and blindness at an early age. We report the clinical and laboratory data of the first published case from Ethiopia of an 18 year old boy with multi-system manifestations of the Bardet-Biedl Syndrome. We discuss the main clinical manifestations of the syndrome including its potentially blinding and fatal features. We emphasize the need for diagnosis of this syndrome at as an early age as possible so that proper and multidisciplinary medical care can be given for such patients to prevent unnecessary morbidity and early mortality.
description: Ethiopian Journal of Health and Biomedical Sciences, Vol. 6 No. 1 (2014): ETHIOPIAN JOURNAL OF HEALTH AND BIOMEDICAL SCIENCES
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 12.01.1966, erstellt von Salih Karaali an der Universitätssternwarte Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1966

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Universitesi Observatuari, Beyazit (Istanbul). Instrument: Zeiss Refraktor Teleskop (Öffnung 130 mm, f = 2000 mm, projiziertes Sonnenbild D = 25 cm)
Interior estimates for Monge-Ampère type fourth order equations
Creators: name: Wang, Ling
name: Zhou, Bin
Publisher: name: arXiv
Year: 2022
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: In this paper, we give several new approaches to study interior estimates for a class of fourth order equations of Monge-Ampère type. First, we prove interior estimates for the homogeneous equation in dimension two by using the partial Legendre transform. As an application, we obtain a new proof of the Bernstein theorem without using Caffarelli-Gutiérrez's estimate, including the Chern conjecture on affine maximal surfaces. For the inhomogeneous equation, we also obtain a new proof in dimension two by an integral method relying on the Monge-Ampère Sobolev inequality. This proof works even when the right hand side is singular. In higher dimensions, we obtain the interior regularity in terms of integral bounds on the second derivatives and the inverse of the determinant.
description: Online first in Revista Matematica Iberoamericana. 29 pages. Minor revision of last version
Framing Han-Uyghur relations on Youtube
Creators: name: Farr, Michael Paul
Publisher: name: University of Utah
Year: 2012
Subjects: China
Ethnic
Han
Uighur
Uyghur
YouTube

description: This study addresses the most salient issues surrounding the tensions between the Ethnic Han and Uyghur in the People's Republic of China from the perspective of the  nonestablishment. Using YouTube.com as a source, this study analyzes the videos uploaded to that website as well as the commentary associated with the videos, both  posted by everyday netizens. This study concludes that many of the issues traditional sources have found to be relevant are also prevalent on YouTube.com. Additionally, this study suggests that there is dissatisfaction among the Han on the way the Chinese  government handles its ethnic policy, especially as it relates to the Uyghur.   This study also addresses some of the methodological problems associated with using the Internet as a source and YouTube in particular. This study suggests that while  attribution can be difficult, if not impossible to ascertain, this peculiarity of the Internet also allows for more open and honest discussion of difficult ethnic issues denied  traditional sources. It was also concluded that YouTube has the potential to help refine and guide the utilization of traditional sources. This study hopes to have established that meaningful original research can be conducted on the Internet and on YouTube.com.
Translational control of the lambda late operon
Creators: name: Sampson, Laura L.
Publisher: name: University of Utah
Year: 2012
Subjects: Morphogenetic
Escherichia coli

description: Translation initiation in E. coli has been studied extensively using genetic, biochemical and sequence analysis methods.  These studies have given us a basic knowledge concerning the characteristics of the translation initiation signal, but have not enable us to predict with certainty which sequences will function as translation initiation signals and which will not.  There are also few data indicating which translation initiation signals are "strong" and which are "weak."  It seems clear that adherence to the observed concensus sequence does not guarantee that a sequence can efficiently bind ribosomes to initiate translation.  A model system which may help to answer the question of what is a "good"  translation initiation signal is the late operon of bacteriophage lambda.  This operon contains the morphogenetic genes of the phage, and is equally transcribed from the single late promoter.  Although the rates of expression of the various genes of this operon have been shown to vary by nearly 1000-fold, their functional mRNA half-lives vary by less than 2-fold.  Clearly the rate of expression of the genes of this operon are under translational control.  This control, however, could be exercised at the level of initiation of elongation, or both.  To determine the level at which the translational control of  the lambda late operon occurs, we have cloned the sequences surrounding the initiator codons of several of these genes and fused them in frame to a cloned lac z gene from Escherichia coli which lacks its own translation initiation signals.  The rates of expression of these hybrid proteins correlate well with the rates of expression of the phage genes from which their translation initiation signals were cloned.  They do not, however, correlate with the number of "rare" codons contributed by the phage DNA.  It thus seems clear that translation initiation controls the relative  rates of synthesis of the lambda late gene.
ASSESMENT ON THE STATUS OF SALMONELLA AND SCHISTOSOMA COINFECTIONS IN THE MIDDLE AWASH VALLEY AND ZIWAY, ETHIOPIA”
Creators: name: Aemero, Mulugeta
name: Erko, Berhanu
name: Ashenafi, Mogessie
name: Erku, Woldaregay
Publisher: name: Ethiopian Journal of Health and Biomedical Sciences
Year: 2014

description: BACKGROUND: Salmonellosis and schistosomiasis are prevalent diseases in Ethiopia. Although both are prevalent, the presence and magnitude of Salmonella and schistosome co-infections has not been assessed. The aim of this cross-sectional study was, therefore, to assess co-infection with Salmonella and Schistosoma in the Middle Awash Valley and Ziway, Ethiopia. METHODS: A total of 423 stool samples from Bochesa village around Ziway and 211 urine samples from Asoba village in the Middle Awash Valley, were diagnosed for Schistosoma mansoni (using Kato-Katz method) and Schistosoma haematobium (using dipstick) in 2004, respectively. Out of these, 158 stool and 127 urine specimens from both schistosomiasis positive and negative subjects were cultured for Salmonella infection. RESULTS: The prevalence of Schistosoma mansoni among students and residents in Bochesa was 71.5% and 54.1%, respectively, while the prevalence of Schistosoma haematobium among residents in Asoba Village was 48.8%. Non-lactose fermenting bacteria were found in 19 S. mansoni positive and 6 S. mansoni negative stool specimens. In the urine specimens positive for S. haematobium infection, 45 lactose fermentors and 52 non-lactose fermentors were found. On the other hand, out of S. haematobium negative urine specimens, 3 lactose fermentor and 27 non-lactose fermentor bacteria were encountered. However, Salmonella was not identified among all non-lactose fermentor colonies. CONCLUSION: The results indicated the absence of association between salmonellosis and schistosomiasis in this particular study. Nevertheless, further study in other schistosome endemic areas of Ethiopia is recommended prior to concluding the absence of association between salmonellosis and schistosomiasis in Ethiopia.
description: Ethiopian Journal of Health and Biomedical Sciences, Vol. 6 No. 1 (2014): ETHIOPIAN JOURNAL OF HEALTH AND BIOMEDICAL SCIENCES
Sonnenfleckenzeichnung Nr. 21126.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.07.1962, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1962

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung Nr. 21137.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 31.07.1962, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1962

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Glycosaminoglycans and their binding proteins:  biochemical studies and development of potential wound healing biomaterials
Creators: name: Cai, Shenshen
Publisher: name: University of Utah
Year: 2012

description: Glycosaminoglycans (GAGS), including hyaluronic acid (HA), heparin, heparan sulfate (HS), chondroitin sulfate (CS), dermatan sulfate (DS), and keratan sulfate (KS) are natural polysaccharides widely distributed in the extracellular matrix (ECM), cell surface, and the basement membrane. GAGs bind numerous proteins, which integrate them into many essential biological pathways. Therefore, studying GAGs and their binding proteins is important for the application of GAGs in biotechnology, pharmaceutical, and medical fields. This dissertation mainly discusses HA and heparin, with some biochemical studies with their binding proteins and potential applications to develop wound-healing biomaterials. An HA binding protein, RHAMM (receptor of HA-mediated motility), was engineered to generate a recombinant protein (HB3) with excellent heparin affinity and specificity. Therapeutically relevant heparin (both unfractionated and low molecular weight) can be measured using HB3 protein in a competition assay modified from an enzyme-linked immunosorbent assay (ELISA). This heparin assay has advantages in high consistency and low cost over current methods of activated partial thromboplastin time (APTT) and anti-Xa assays. Another important HA binding protein, SPACRCAN (sialoproteoglycan associated with cones and rods) in retinal areas, was found to bind with heparin and CS. The binding domain was identified to be RHAMM-like BX7
Sonnenfleckenzeichnung Nr. 21198.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 05.10.1962, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1962

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Unter Umständen sind Angaben zu Protuberanzen vermerkt
IC MAGE UMIP - universal model interface for PLAXIS
Creators: name: Taborda, David M G
name: Kontoe, Stavroula
name: Tsiampousi, Aikaterini
Publisher: name: Zenodo
Year: 2023
Subjects: Geotechnical Analysis
Finite Element Analysis
Constitutive Modelling
Geotechnical Engineering

description: Documentation for IC MAGE's Universal Model Interface for PLAXIS. The Universal Model Interface for PLAXIS (UMIP) is a platform designed to facilitate the implementation of constitutive models into PLAXIS. Currently, the only integration scheme available for the constitutive relationship is a Modified Euler substepping scheme with automatic error control.
description: {"references": ["Azeiteiro, R.J.N. (2021) Numerical simulation of liquefaction-related phenomena. PhD Thesis, University of Coimbra, Portugal.", "Dowell, M. and Jarratt, P. (1972). The 'Pegasus' method for computing the root of an equation. BIT Numerical Mathematics, 12 (4), 503\u2013508.", "Hong, P.Y., Pereira, J.M., Cui, Y.J. and Tang, A.M. (2012). Explicit integration of a thermo-mechanical model for clays. Computers and Geotechnics, 46, 13\u201325.", "Potts, D.M. and Gens, A. (1985). A critical assessment of methods of correcting for drift from the yield surface in elasto-plastic finite element analysis. International Journal for Numerical and Analytical Methods in Geomechanics, 9 (2), 149\u2013159.", "Potts, D.M. and Zdravkovic, L. (1999). Finite element analysis in geotechnical engineering. Theory. London, U.K., Thomas Telford Publishing.", "Sloan, S.W. (1987). Substepping schemes for numerical integration of elasto-plastic stress-strain relations. International Journal for Numerical Methods in Engineering, 24 (5), 893\u2013911.", "Sloan, S.W., Abbo, A.J. and Sheng, D. (2001). Refined explicit integration of elastoplastic models with automatic error control. Engineering Computations, 18 (1), 121\u2013194.", "Taborda, D.M.G., Potts, D.M. and Zdravkovi\u0107, L. (2016). On the assessment of energy dissipated through hysteresis in finite element analysis. Computers and Geotechnics, 71, 180\u2013194.", "Taborda, D.M.G and Zdravkovi\u0107, L. (2012). Application of a Hill-Climbing technique to the formulation of a new cyclic nonlinear elastic constitutive model. Computers and Geotechnics, 43, 80-91."]}
A SIQRB delayed model for cholera and optimal control treatment
Creators: name: Lemos-Paiao, Ana P.
name: Maurer, Helmut
name: Silva, Cristiana J.
name: Torres, Delfim F. M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optimization and Control (math.OC)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Mathematics
subject: FOS: Biological sciences
subject: 34C60, 49K15, 92D30

description: We improve a recent mathematical model for cholera by adding a time delay that represents the time between the instant at which an individual becomes infected and the instant at which he begins to have symptoms of cholera disease. We prove that the delayed cholera model is biologically meaningful and analyze the local asymptotic stability of the equilibrium points for positive time delays. An optimal control problem is proposed and analyzed, where the goal is to obtain optimal treatment strategies, through quarantine, that minimize the number of infective individuals and the bacterial concentration, as well as treatment costs. Necessary optimality conditions are applied to the delayed optimal control problem, with a $L^1$ type cost functional. We show that the delayed cholera model fits better the cholera outbreak that occurred in the Department of Artibonite -- Haiti, from 1 November 2010 to 1 May 2011, than the non-delayed model. Considering the data of the cholera outbreak in Haiti, we solve numerically the delayed optimal control problem and propose solutions for the outbreak control and eradication.
description: This is a preprint of a paper whose final and definite form is published Open Access in 'Math. Model. Nat. Phenom.' at [https://www.mmnp-journal.org]. Submitted to MMNP: Sept 23, 2021; Revised: March 15, 2022; Accepted: June 25, 2022
Sonnenfleckenzeichnung Nr. 21233.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.11.1962, erstellt von Helmut Müller und Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1962

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung Nr. 21133.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 26.07.1962, erstellt von Helmut Müller
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1962

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Perceptual Conversational Head Generation with Regularized Driver and Enhanced Renderer
Creators: name: Huang, Ailin
name: Huang, Zhewei
name: Zhou, Shuchang
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: This paper reports our solution for ACM Multimedia ViCo 2022 Conversational Head Generation Challenge, which aims to generate vivid face-to-face conversation videos based on audio and reference images. Our solution focuses on training a generalized audio-to-head driver using regularization and assembling a high-visual quality renderer. We carefully tweak the audio-to-behavior model and post-process the generated video using our foreground-background fusion module. We get first place in the listening head generation track and second place in the talking head generation track on the official leaderboard. Our code is available at https://github.com/megvii-research/MM2022-ViCoPerceptualHeadGeneration.
description: Ailin and Zhewei contributed equally to this work. ACM MM22 workshop paper
Very Large Array Multi-band Radio Imaging of the Triple AGN Candidate SDSS J0849+1114
Creators: name: Peng, Sijia
name: Li, Zhiyuan
name: Liu, Xin
name: Nyland, Kristina
name: Wrobel, Joan M.
name: Hou, Meicun
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Kpc-scale triple active galactic nuclei (AGNs), potential precursors of gravitationally-bound triple massive black holes (MBHs), are rarely seen objects and believed to play an important role in the evolution of MBHs and their host galaxies. In this work we present a multi-band (3.0, 6.0 10.0, and 15.0 GHz), high-resolution radio imaging of the triple AGN candidate, SDSS J0849+1114, using the Very Large Array. Two of the three nuclei (A and C) are detected at 3.0, 6.0, and 15 GHz for the first time, both exhibiting a steep spectrum over 3--15 GHz (with a spectral index $-0.90 \pm 0.05$ and $-1.03 \pm 0.04$) consistent with a synchrotron origin. Nucleus A, the strongest nucleus among the three, shows a double-sided jet, with the jet orientation changing by $\sim20^{\circ}$ between its inner 1" and the outer 5.5" (8.1 kpc) components, which may be explained as the MBH's angular momentum having been altered by merger-enhanced accretion. Nucleus C also shows a two-sided jet, with the western jet inflating into a radio lobe with an extent of 1.5" (2.2 kpc). The internal energy of the radio lobe is estimated to be $\rm 5.0 \times 10^{55}$ erg, for an equipartition magnetic field strength of $\rm \sim 160\ μG$. No significant radio emission is detected at all four frequencies for nucleus B, yielding an upper limit of 15, 15, 15, and 18 $\rm μJy\ beam^{-1}$ at 3.0, 6.0, 10.0, and 15.0 GHz, based on which we constrain the star formation rate in nucleus B to be $\lesssim 0.4~\rm M_{\odot}~yr^{-1}$.
description: 11 pages, 3 figures, accepted for publication in ApJ. Comments welcome
Block of neuromuscular transmission by conotoxins GI and GII.
Creators: name: McManus, Owen Bernard
Publisher: name: University of Utah
Year: 2012
Subjects: Physiological Effect
Conus Geographus

description: Two similar peptide neurotoxins from the venom of the marine snail Conus geographus were found to block neuromuscular transmission in the frog and in the mouse. Initial experiments were done with an equimolar mixture of Conotoxins GI and GII. The GI-GII mixture was found to block nerve-evoked muscle contractions, but have no effect on contractions of directly stimulated muscle. Conotoxins GI-GII blocked endplate potentials and miniature endplate potentials apparently at a postsynaptic site because the toxins reduced endplate potential amplitude while having no significant effect on the quantal content of endplate potentials. In addition, Conotoxins GI-GII inhibited the binding of (alpha)-Bungarotoxin to acetylcholine receptors at the neuromuscular junction suggesting that Conotoxins GI-GII block neuromuscular transmission at a postsynaptic site by blocking acetylcholine receptors.  Further experiments examined the effects of a synthetic form of Conotoxin GI on the postsynaptic membrane at the neuromuscular junction. Conotoxin GI reduced the sensitivity of muscle to ionophoretically applied acetylcholine further suggesting a postsynaptic site of action. This reduction in the sensitivity of the muscle to acetylcholine caused by Conotoxin GI was not due to changes in muscle fibre resting membrane potential or input resistance. Conontoxin GI reduced the amplitude of extracellularly recorded endplate currents and miniature endplate currents, but had no apparent effect on the rate of decay of endplate or miniature endplate currents, suggesting that the toxin has no effect on the lifetime of ion channels opened by acetylcholine. When acetylcholinesterase is blocked, miniature endplate currents decay five to six times more slowly than normal, and this rate of decay reflects the rate of diffusion of acetylcholine from the synaptic cleft. This rate of diffusion is prolonged compared to free diffusion due to repeated binding of acetylcholine to receptors as it diffuses from the cleft. Conotoxin GI significantly reduced the amplitude and increased the rate of decay of extracellularly recorded miniature endplate currents with acetylcholinesterase blocked, suggesting that Conotoxin GI reduces the binding of acetylcholine to receptors at the neuromuscular junction. In summary, Conotoxin GI blocks vertebrate neuromuscular transmission apparently by binding to acetylcholine receptors and thereby reducing the binding of acetylcholine to its receptor.
Sonnenfleckenzeichnung Nr. 21135.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.07.1962, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1962

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Unter Umständen sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.11.1962, erstellt von Dendis am Skalnate Pleso Observatorium
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1962

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Skalnate Pleso Observatorium. Es sind zudem statistische Angaben für die Bestimmung der Fleckenrelativzahl notiert. Instrument: unbekannt, Sonnenbild D = 25 cm
IC MAGE UMIP - universal model interface for PLAXIS
Creators: name: Taborda, David M G
name: Kontoe, Stavroula
name: Tsiampousi, Aikaterini
Publisher: name: Zenodo
Year: 2023
Subjects: Geotechnical Analysis
Finite Element Analysis
Constitutive Modelling
Geotechnical Engineering

description: The Universal Model Interface for PLAXIS (UMIP) is a platform designed to facilitate the implementation of user-defined soil models (UDSM) into PLAXIS. It includes an interface with the information passed by PLAXIS’ kernel to the UDSM and general-purpose algorithms based on the Modified Euler sub-stepping approach with automatic error control. Additionally, it provides a repository for subroutines and functions that perform standard operations shared among different models. It is continuously expanding to deal with the wide range of models under development within the IC MAGE group.
description: {"references": ["Azeiteiro, R.J.N. (2021) Numerical simulation of liquefaction-related phenomena. PhD Thesis, University of Coimbra, Portugal.", "Dowell, M. and Jarratt, P. (1972). The 'Pegasus' method for computing the root of an equation. BIT Numerical Mathematics, 12 (4), 503\u2013508.", "Hong, P.Y., Pereira, J.M., Cui, Y.J. and Tang, A.M. (2012). Explicit integration of a thermo-mechanical model for clays. Computers and Geotechnics, 46, 13\u201325.", "Potts, D.M. and Gens, A. (1985). A critical assessment of methods of correcting for drift from the yield surface in elasto-plastic finite element analysis. International Journal for Numerical and Analytical Methods in Geomechanics, 9 (2), 149\u2013159.", "Potts, D.M. and Zdravkovic, L. (1999). Finite element analysis in geotechnical engineering. Theory. London, U.K., Thomas Telford Publishing.", "Sloan, S.W. (1987). Substepping schemes for numerical integration of elasto-plastic stress-strain relations. International Journal for Numerical Methods in Engineering, 24 (5), 893\u2013911.", "Sloan, S.W., Abbo, A.J. and Sheng, D. (2001). Refined explicit integration of elastoplastic models with automatic error control. Engineering Computations, 18 (1), 121\u2013194.", "Taborda, D.M.G., Potts, D.M. and Zdravkovi\u0107, L. (2016). On the assessment of energy dissipated through hysteresis in finite element analysis. Computers and Geotechnics, 71, 180\u2013194.", "Taborda, D.M.G and Zdravkovi\u0107, L. (2012). Application of a Hill-Climbing technique to the formulation of a new cyclic nonlinear elastic constitutive model. Computers and Geotechnics, 43, 80-91."]}
Reflecting on gratitude: promoting healthy lifestyles in adults
Creators: name: Bataller, Joaquin Fenollar
Publisher: name: University of Utah
Year: 2012
Subjects: Depression
Gratitude
Healthy lifestyle
Journal writing
Obesity
Physical activity

description: The main aim of this study was to examine the effectiveness of an innovative health prevention program, the Healthy and Fit Adults Program (HFAP). The HFAP consists of five sessions designed after an effective evidence-based family skills training intervention, the Strengthening Families Program, which uses Bandura's (1986) Social Cognitive Theory in order to increase protective factors against health risk behaviors.   The HFAP intervention included two elements (reflecting on gratitude and expressive writing as the vehicle to reflect on gratitude) as means to improve healthy behaviors. It was hypothesized that those participating in the HFAP would increase health protective factors against obesity (physical activity) and decrease health risk factors for obesity (excessive weight and depression).  This study employed a quasi-experimental design (no treatment comparison and treatment groups) in order to assess the impact of the HFAP on the health behaviors of 48 voluntary participants ages 31 to 45. Standardized measures included self-reported scales to measure physical activity (IPAQ), gratitude (GQ-6), and depression (CES-D) as well as objective measures (pedometer and BMI). Data were collected and analyzed using parametric and nonparametric tests (RM-ANOVAS, ANCOVA, Paired Samples t test, Wilcoxon Signed Ranks Tests, Spearman Correlation Coefficient).  Results showed statistically significant increases in self-reported gratitude as well as a significant decrease in depression scores within the experimental group from pretest to posttest. Self-reported physical activity measured in METs also increased significantly within the experimental group from pretest to posttest. These results were only statistically significant when baseline differences between groups were not accounted for.  When baseline differences were considered (ANCOVA), the differences in main outcomes (physical activity in METs and steps, gratitude, BMI, and depression) between  comparison and treatment groups from pretest to posttest were not statistically significant. There was, however, a statistically significant moderate negative correlation between levels of gratitude and depression among participants.  In this study, reflecting and practicing gratitude seemed to contribute to healthier psychological self-perceptions of participants (i.e., improved gratitude and decreased  depression). Findings are discussed and suggestions for future research and interventions aiming to prevent obesity among adults are provided.
IC MAGE UMIP - universal model interface for PLAXIS
Creators: name: Taborda, David M G
name: Kontoe, Stavroula
name: Tsiampousi, Aikaterini
Publisher: name: Zenodo
Year: 2024
Subjects: Geotechnical Analysis
Finite Element Analysis
Constitutive Modelling
Geotechnical Engineering

description: The Universal Model Interface for PLAXIS (UMIP) is a platform designed to facilitate the implementation of user-defined soil models (UDSM) into PLAXIS. It includes an interface with the information passed by PLAXIS’ kernel to the UDSM and general-purpose algorithms based on the Modified Euler sub-stepping approach with automatic error control. Additionally, it provides a repository for subroutines and functions that perform standard operations shared among different models. It is continuously expanding to deal with the wide range of models under development within the IC MAGE group.