cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Development of B-1 cells: segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression
Creators: name: Arnold, Larry W.
name: Mc Cray, Suzanne K.
name: Pennell, Christopher A.
name: Clarke, Stephen H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1994

description: Adult mice have two easily recognizable subsets of B cells: the predominant resting population of the spleen, called B-2, and those called B-1, which predominate in coelomic cavities and can express CD5. Some antibody specificities appear to be unique to the B-1 population. Cells expressing antibody specific for phosphatidyl choline (PtC) are the most frequent, comprising 2-10% of peritoneal B cells in normal mice. To understand the basis for the segregation of the anti-PtC specificity to this population, we have produced transgenic (Tg) mice expressing the rearranged VH12 and V kappa 4 genes of a PtC-specific B- 1 cell lymphoma. We find that VH12-Tg and VH12/V kappa 4 double-Tg mice develop very high numbers of PtC-specific peritoneal and splenic B cells. These cells have the characteristics of B-1 cells; most are CD5+, and are all IgMhi, B220lo, and CD23-. In the peritoneum these cells are also CD11b+. In addition, adult mice have many splenic B cells (up to one third of Tg+ cells) that express the VH12 Tg but do not bind PtC, presumably because they express a V kappa gene other than V kappa 4. These cells appear to be B-2 cells; they are CD23+, CD11b-, IgMlo, B220hi, and CD5-. Thus, mice given either the VH12 Tg alone or together with the V kappa 4 Tg develop a large population of PtC- specific B cells which belong exclusively to the B-1 population. Since B-2 cells can express the VH12 and V kappa 4 gene separately, we interpret these data to indicate that the events leading to the segregation of PtC-specific B cells to the B-1 population in normal mice are initiated after Ig gene rearrangement and expression. These data are discussed with regard to hypotheses of the origin of B-1 cells. We also find that VH12-Tg mice have a marked decrease in the generation of Tg-expressing B cells in adult bone marrow, but not newborn liver. We speculate that this may be related to positive selection of VH12-expressing B cells during differentiation.
Induction of lupus-associated autoantibodies in BALB/c mice by intraperitoneal injection of pristane
Creators: name: Satoh, Minoru
name: Reeves, Westley H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1994

description: Intraperitoneal injection of pristane (2,6,10,14 tetramethylpentadecane) is a standard technique for obtaining monoclonal antibody-enriched ascitic fluid. However, pristane also induces plasmacytomas and an erosive arthritis resembling rheumatoid arthritis in BALB/c mice, probably as a consequence of enhanced interleukin 6 production. We report here that the production of autoantibodies characteristic of systemic lupus erythematosus (SLE) is a further consequence of injecting pristane in BALB/c mice. Anti-Su antibodies appeared as early as 1-2 mo after a single injection of 0.5 ml pristane, followed by anti-U1RNP and anti-Sm antibodies after 2-4 mo. Within 6 mo of pristane injection, 9 of 11 BALB/c mice had developed anti-Su, anti-U1RNP, anti-U2RNP, anti-Sm, and possibly anti- U5RNP antibodies. Autoantibodies were not produced by 20 BALB/c mice of the same age and sex that were not injected with pristane. Thus, autoantibodies characteristic of lupus were induced in mice that are not usually considered to be genetically susceptible to the disease. The induction of autoantibodies associated with SLE by pristane may be relevant to understanding the role of abnormal cytokine production in autoantibody production and the pathogenesis of autoimmune disease. Furthermore, the induction of high titer autoantibodies by pristane dictates caution in the use of ascitic fluid as a source of monoclonal antibodies, since the polyclonal antibodies induced by pristane may copurify with the monoclonal antibody secreted by an injected hybridoma.
(3758) Ann McLaren
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Initiation of autoimmunity to the p53 tumor suppressor protein by complexes of p53 and SV40 large T antigen
Creators: name: Satoh, Minoru
name: Deng, Xingwen
name: Hamilton, Kimberly J.
name: Reeves, Westley H.
name: Wang, Jingsong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1994

description: Antinuclear antibodies (ANAs) reactive with a limited spectrum of nuclear antigens are characteristic of systemic lupus erythematosus (SLE) and other collagen vascular diseases, and are also associated with certain viral infections. The factors that initiate ANA production and determine ANA specificity are not well understood. In this study, high titer ANAs specific for the p53 tumor suppressor protein were induced in mice immunized with purified complexes of murine p53 and the Simian virus 40 large T antigen (SVT), but not in mice immunized with either protein separately. The autoantibodies to p53 in these mice were primarily of the IgG1 isotype, were not cross-reactive with SVT, and were produced at titers up to 1:25,000, without the appearance of other autoantibodies. The high levels of autoantibodies to p53 in mice immunized with p53/SVT complexes were transient, but low levels of the autoantibodies persisted. The latter may have been maintained by self antigen, since the anti-p53, but not the SVT, response in these mice could be boosted by immunizing with murine p53. Thus, once autoimmunity to p53 was established by immunizing with p53/SVT complexes, it could be maintained without a requirement for SVT. These data may be explained in at least two ways. First, altered antigen processing resulting from the formation of p53/SVT complexes might activate autoreactive T helper cells specific for cryptic epitopes of murine p53, driving anti-p53 autoantibody production. Alternatively, SVT- responsive T cells may provide intermolecular-intrastructural help to B cells specific for murine p53. In a second stage, these activated B cells might themselves process self p53, generating p53-responsive autoreactive T cells. The induction of autoantibodies during the course of an immune response directed against this naturally occurring complex of self and nonself antigens may be relevant to the generation of specific autoantibodies in viral infections, and may also have implications for understanding the pathogenesis of ANAs in SLE. In particular, our results imply that autoimmunity can be initiated by a "hit and run" mechanism in which the binding of a viral antigen to a self protein triggers an immune response that subsequently can be perpetuated by self antigen.
Ganzheitliche Reflexion auf dem Weg zu Selbstorganisiertem Lernen
Creators: name: Jenert, Tobias
Publisher: name: bildungsforschung
Year: 2010

description: Selbstlernfähigkeit gilt als ein wichtiges Bildungsziel der Hochschule. Reflexives Lernen kann Studierenden helfen, ihre Lernaktivitäten selbst zu organisieren und ihre Selbstlernkompetenz auszubauen. Der Beitrag zeigt auf, welche lernrelevanten Aspekte Gegenstand von reflexivem Lernen sein können. Ausgehend von einem Beispiel aus der Hochschullehre werden dazu drei Reflexionsebenen beschrieben, die auf dem Weg zu selbstorganisiertem Lernen ganzheitlich angesprochen werden sollten.
description: bildungsforschung, Bd. 2 (2008): Reflexives Lernen
Multi-agent Reinforcement Learning with Sparse Interactions by Negotiation and Knowledge Transfer
Creators: name: Zhou, Luowei
name: Yang, Pei
name: Chen, Chunlin
name: Gao, Yang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Multiagent Systems (cs.MA)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Reinforcement learning has significant applications for multi-agent systems, especially in unknown dynamic environments. However, most multi-agent reinforcement learning (MARL) algorithms suffer from such problems as exponential computation complexity in the joint state-action space, which makes it difficult to scale up to realistic multi-agent problems. In this paper, a novel algorithm named negotiation-based MARL with sparse interactions (NegoSI) is presented. In contrast to traditional sparse-interaction based MARL algorithms, NegoSI adopts the equilibrium concept and makes it possible for agents to select the non-strict Equilibrium Dominating Strategy Profile (non-strict EDSP) or Meta equilibrium for their joint actions. The presented NegoSI algorithm consists of four parts: the equilibrium-based framework for sparse interactions, the negotiation for the equilibrium set, the minimum variance method for selecting one joint action and the knowledge transfer of local Q-values. In this integrated algorithm, three techniques, i.e., unshared value functions, equilibrium solutions and sparse interactions are adopted to achieve privacy protection, better coordination and lower computational complexity, respectively. To evaluate the performance of the presented NegoSI algorithm, two groups of experiments are carried out regarding three criteria: steps of each episode (SEE), rewards of each episode (REE) and average runtime (AR). The first group of experiments is conducted using six grid world games and shows fast convergence and high scalability of the presented algorithm. Then in the second group of experiments NegoSI is applied to an intelligent warehouse problem and simulated results demonstrate the effectiveness of the presented NegoSI algorithm compared with other state-of-the-art MARL algorithms.
description: 13 pages, 15 figures
Three new species of Syllis (Syllidae: Polychaeta) from Iberian coasts
Creators: name: SAN MARTÍN, Guillermo
name: LÓPEZ, Eduardo
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2000

description: During the project "Fauna Ibérica", established to develop a complete study of the Iberian fauna, several new
 polychaete species belonging to the family Syllidae were found and we describe here three new species included in the genus
 Syllis. Syllis parapari sp. nov. is characterized by the presence of both pseudospiniger and falciger compound chaetae, short
 and spindle-shaped dorsal cirri on midbody parapodia and posterior aciculae with an oblique tip and a subdistal knob.
S. pontxioi sp. nov. is characterized by very short antennae, tentacular and dorsal cirri; by the shape of midbody and posterior
 chaetal blades, very short and with an enlarged distal tooth; by stout posterior aciculae, with a slightly curved tip. S. jorgei
 sp. nov. is characterized by very long spines on the cutting edge of falciger blades, the distal ones longer than the terminal
 tooth, by the shape of aciculae with subdistal knobs and acute tips. These three species have been previously reported for the
 Iberian fauna as Syllis cornuta, S. gerlachi, and S. lutea. However, after comparison with a recent re-description of these
 species, the authors conclude that the species studied here are three new species.
Theoretische Zugänge und Methoden zur Reflexion des Lernens. Ein Diskussionsbeitrag
Creators: name: Hilzensauer, Wolf
Publisher: name: bildungsforschung
Year: 2010

description: In der Literatur sind nur wenige theoretischen und detaillierte Hinweise auf die Reflexionsprozesse über das Lernen selbst zu finden. Im vorliegenden Artikel werden theoretische und methodische Herangehensweisen zur Reflexion auf ihre Übertragbarkeit für reflexives Lernen überprüft. Darüber hinaus wird ein Modell skizziert, das Reflexion auf drei unterschiedlichen Ebenen beschreibt. Schließlich wird versucht, Elemente der Dialogischen Didaktik für eine Beschreibung unterschiedlicher Entwicklungsstufen in der Reflexionskompetenz zu übertragen.
description: bildungsforschung, Bd. 2 (2008): Reflexives Lernen
A new species of Isobactrus from the Black Sea (Acari, Halacaridae, Rhombognathinae)
Creators: name: BARTSCH, Ilse
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2000

description: A new species, Isobactrus ponticus, is described. The species is an inhabitant of barnacles near the high water
 edge; it is characterized by a dorsal shield. This is the second report on the genus Isobactrus from the Black Sea.
(3760) [?] [White]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 1 of Acid sphingomyelinase modulates anxiety-like behavior likely through toll-like receptor signaling pathway
Creators: name: Yuan, Huiqi
name: Xu, Yanan
name: Jiang, Hailun
name: Jiang, Meizhu
name: Zhang, Luofei
name: Wei, Shifeng
name: Li, Cao
name: Zhao, Zhigang
Publisher: name: figshare
Year: 2025
Subjects: subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Supplementary Material 1: Fig. S1 Depression-like behaviors in Asm KO and WT mice. Fig. S2 Anxiety-like behaviors in female and male Asm KO and WT mice. Fig. S3 Depression-like behaviors in female and male Asm KO and WT mice. Fig. S4 Cerebral blood flow in female and male Asm KO and WT mice
Recent ALICE results on hadronic resonance production
Creators: name: Badalà, Angela
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Hadronic resonances are a valuable tool to study the properties of the medium formed in heavy-ion collisions. In particular, they can provide information on particle-formation mechanisms and on the properties of the medium at chemical freeze-out. Furthermore they contribute to the systematic study of parton energy loss and quark recombination. Measurements of resonances in pp and in p-Pb collisions provide a necessary baseline for heavy-ion data and help to disentangle initial-state effects from medium-induced effects. In this paper the latest ALICE results on mid-rapidity K*(892)^0 and ϕ(1020) production in pp, p-Pb and Pb-Pb collisions at LHC energies are presented
description: Talk at International Conference on Dark Matter, Hadron Physics and Fusion Physics, 24-26 Septemeber 2014, Messina(Italy)
Überlegungen zur Vermittlung metakognitiver Kompetenz in der Sportlehrerausbildung durch Forschendes Lernen
Creators: name: Blotzheim, Dirk
name: Kamper, Svenja
name: Schneider, Ralf
Publisher: name: bildungsforschung
Year: 2010

description: In diesem Beitrag wird vor dem skizzierten Hintergrund des Problems von Wissen und Handeln in der Sportlehrerausbildung aufgezeigt, welchen Beitrag das hochschuldidaktische Konzept des Forschenden Lernens zur Vermittlung metakognitiver Kompetenz als zentralem Bestandteil reflexiven Lernens leisten kann.
description: bildungsforschung, Bd. 2 (2008): Reflexives Lernen
Multiple gonococcal opacity proteins are expressed during experimental urethral infection in the male
Creators: name: Whicker, Leesa G.
name: Drown, Penny M.
name: Cannon, Janne G.
name: Isbey, Susan F.
name: Cohen, Myron S.
name: Jerse, Ann E.
name: Seifert, H. Steven
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1994

description: The opacity (Opa) proteins of Neisseria gonorrhoeae are a family of outer membrane proteins demonstrating phase and antigenic variation. N. gonorrhoeae strain FA0190 has 11 opa loci that encode at least 8 antigenically distinct Opa proteins. To determine if expression of one Opa protein or a subset of them is favored during gonococcal infection, we inoculated Opa-negative variants of strain FA1090 intraurethrally into male volunteers. The Opa phenotype of gonococci isolated from urine and urethral swab cultures from nine infected subjects was determined. Opa proteins were expressed in a large proportion of the reisolates from the infected subjects. Gonococci cultured from urine or urethral swab samples from six of the subjects were uniformly Opa positive, with the predominant Opa variants differing among subjects. Three different Opa proteins were represented as the predominant type in at least one subject each. In three subjects, there was more heterogeneity in Opa phenotype of the reisolates, including the presence of Opa-negative variants. An increase in the proportion of isolates expressing multiple Opa proteins occurred over time in most subjects. Passage of the inoculum in vitro did not result in similar changes in Opa expression. There was no detectable difference in infectivity of an Opa-negative variant and one expressing an Opa protein (OpaF) that was highly represented in reisolates from the original nine subjects. Reisolates from three infected volunteers inoculated with the OpaF variant showed continued expression of OpaF alone or in conjunction with other Opa proteins. These results demonstrate that there is strong selection for expression of one or more Opa proteins by strain FA1090 in vivo, but that no single protein is preferentially expressed during early infection in the male urethra.
Field Equations in the Complex Quaternion Spaces
Creators: name: Weng, Zi-Hua
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: The paper aims to adopt the complex quaternion and octonion to formulate the field equations for electromagnetic and gravitational fields. Applying the octonionic representation enables one single definition to combine some physics contents of two fields, which were considered to be independent of each other in the past. J. C. Maxwell applied simultaneously the vector terminology and the quaternion analysis to depict the electromagnetic theory. This method edified the paper to introduce the quaternion and octonion spaces into the field theory, in order to describe the physical feature of electromagnetic and gravitational fields, while their coordinates are able to be the complex number. The octonion space can be separated into two subspaces, the quaternion space and the S-quaternion space. In the quaternion space, it is able to infer the field potential, field strength, field source, field equations, and so forth, in the gravitational field. In the S-quaternion space, it is able to deduce the field potential, field strength, field source, and so forth, in the electromagnetic field. The results reveal that the quaternion space is appropriate to describe the gravitational features; meanwhile the S-quaternion space is proper to depict the electromagnetic features.
description: arXiv admin note: substantial text overlap with arXiv:1503.06098
Die Entwicklung pädagogisch professioneller Kommunikation unter Supervision [Einzelbeitrag]
Creators: name: Erbring, Saskia
Publisher: name: bildungsforschung
Year: 2010

description: Für die Gestaltung der Arbeitsbeziehungen mit Schüler/innen und Kolleg/inn/en benötigen Lehrer/innen professionalisierte kommunikative Fähigkeiten. Ein entwickeltes Theoriekonstrukt pädagogisch professioneller Kommunikation wurde mit der Untersuchung des Kommunikationsverhaltens von 12 Lehrern und Lehrerinnen während 15 Supervisionssitzungen empirisch überprüft. Die Ergebnisse der Studie belegen die signifikante Zunahme von Kategorien professioneller Kommunikation im Untersuchungszeitraum (ein Jahr). Supervision kann demnach ein effektives Fortbildungsformat sein, um die kommunikative Professionalität von Lehrpersonen zu fördern.
description: bildungsforschung, Bd. 2 (2008): Reflexives Lernen
The littoral sea cucumbers (Echinodermata: Holothuroidea) of Guam re-assessed  a diversity curve that still does not asymptote
Creators: name: MICHONNEAU, François
name: BORRERO-PEREZ, Giomar Helena
name: HONEY, Magali
name: KAMARUDIN, Kamarul Rahim
name: KERR, Alexander M.
name: KIM, Sun
name: MEÑEZ, Marie Antonette
name: MILLER, Allison
name: OCHOA, Julio Adrián
name: OLAVIDES, Ronald D.
name: PAULAY, Gustav
name: SAMYN, Yves
name: SETYASTUTI, Ana
name: SOLIS-MARIN, Francisco
name: STARMER, John
name: VANDENSPIEGEL, Didier
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: The Micronesian island of Guam has been an important site for the study of littoral tropical holothurian taxonomy for almost 200 years. Despite substantial attention by both expeditions and resident taxonomists, new records are still regularly added to the fauna, demonstrating the challenge of documenting even such large and well-known animals in a small hyper-diverse area. Guam is the type locality of species described by Quoy & Gaimard (1833) and Brandt (1835). A survey of the sea cucumber fauna by Rowe & Doty (1977) led to one of the most used guides for the identification of tropical Pacific sea cucumbers because of the color illustrations of living animals it presented. Focus on echinoderms including holothurians continued with numerous new records added in the following decades. Paulay (2003a) summarized the fauna last, recording 46-47 species. At this stage the fauna was thought to be well documented. A week-long workshop on holothurian systematics sponsored by the National Science Foundation PEET (Partnerships for Enhancing Expertise in Taxonomy) project in 2010 included a substantial field work component, sampling both during the day and night, with snorkeling and SCUBA, across a variety of habitats. This survey yielded 40 species, including numerous new records and even species. Further sampling by Kerr's lab since the workshop has added additional records. The littoral holothuroid fauna of Guam now comprises 65 species in 17 genera and 7 families. Half of the 19 newly recorded species are the result of unravelling cryptic species in complexes, the other half are based on new collections. Eleven species are known from single specimens, suggesting that much still remains to be learned about the fauna.
Ammar's Theory: A Scientific Framework for Multi-Dimensional Energy and Superluminal Travel with references
Creators: name: Ammar, Yasir
name: Valamontes Center For Scientific Publication
Publisher: name: Zenodo
Year: 2025

description: This paper introduces Ammar’s Theory, a new scientific framework to explore the concept of multi-dimensional energy, superluminal travel, and the hierarchical structure of energy sources beyond con-ventional physics. The theory challenges the notion of light as the ultimate speed limit by proposinghigher-order energy forms capable of surpassing known light-speed constraints. This work extends Ein-stein’s relativity, integrates quantum gravitational effects, and introduces novel variables and equationsto mathematically model travel beyond known light-speed barriers.
Tuning the Chern number and Berry curvature with spin-orbit coupling and magnetic textures
Creators: name: McCormick, Timothy M.
name: Trivedi, Nandini
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We obtain the band structure of a particle moving in a magnetic spin texture, classified by its chirality and structure factor, in the presence of spin-orbit coupling. This rich interplay leads to a variety of novel topological phases characterized by the Berry curvature and their associated Chern numbers. We suggest methods of experimentally exploring these topological phases by Hall drift measurements of the Chern number and Berry phase interferometry to map the Berry curvature.
description: 8 pages, 5 figures
(3754) George Monteath
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A rigorous geometric derivation of the chiral anomaly in curved backgrounds
Creators: name: Baer, Christian
name: Strohmaier, Alexander
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Differential Geometry (math.DG)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 81T50, 81T20

description: We discuss the chiral anomaly for a Weyl field in a curved background and show that a novel index theorem for the Lorentzian Dirac operator can be applied to describe the gravitational chiral anomaly. A formula for the total charge generated by the gravitational and gauge field background is derived in a mathematically rigorous manner. It contains a term identical to the integrand in the Atiyah-Singer index theorem and another term involving the $η$-invariant of the Cauchy hypersurfaces.
description: references added, introduction rewritten, examples added, published version
Analysis of Kolmogorov Flow and Rayleigh-Bénard Convection using Persistent Homology
Creators: name: Kramar, Miroslav
name: Levanger, Rachel
name: Tithof, Jeffrey
name: Suri, Balachandra
name: Xu, Mu
name: Paul, Mark
name: Schatz, Michael F.
name: Mischaikow, Konstantin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Topology (math.AT)
subject: Dynamical Systems (math.DS)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We use persistent homology to build a quantitative understanding of large complex systems that are driven far-from-equilibrium; in particular, we analyze image time series of flow field patterns from numerical simulations of two important problems in fluid dynamics: Kolmogorov flow and Rayleigh-Bénard convection. For each image we compute a persistence diagram to yield a reduced description of the flow field; by applying different metrics to the space of persistence diagrams, we relate characteristic features in persistence diagrams to the geometry of the corresponding flow patterns. We also examine the dynamics of the flow patterns by a second application of persistent homology to the time series of persistence diagrams. We demonstrate that persistent homology provides an effective method both for quotienting out symmetries in families of solutions and for identifying multiscale recurrent dynamics. Our approach is quite general and it is anticipated to be applicable to a broad range of open problems exhibiting complex spatio-temporal behavior.
The Echinoderm Files: a database-facilitated access to a hidden treasure trove
Creators: name: KROH, Andreas
name: JANGOUX, Michel
name: MIRANTSEV, Georgy V.
name: ZIEGLER, Alexander
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: During the fifty years that have passed since the first echinoderm meeting was held in 1963, numerous scientific articles on the phylum Echinodermata have been published in conference proceedings volumes or as special symposium journal issues. In order to provide the research community with a more rapid access to the information contained within these publications, we have compiled a database that lists all abstracts and articles published following the main gatherings of the echinoderm scientific community over the past half century. This database, The Echinoderm Files, is available online and contains bibliographical data on abstracts and articles from proceedings of International Echinoderm Conferences, European Conferences on Echinoderms, and all major international echinoderm symposia. Analyses performed based on the content of the database illustrate trends related to the echinoderm scientific community, its conferences, and related proceedings. Among other aspects, these studies reveal a steady increase in conference attendance, an uneven distribution of taxonomic research foci, and a relatively low visibility of research published in conference proceedings. In addition, the article lists the additional past echinoderm conferences, provides data on future echinoderm meetings, and discusses the accessibility of echinoderm-related publications.
YB-1 DNA-binding protein represses interferon gamma activation of class II major histocompatibility complex genes
Creators: name: Painter, Audrey
name: Moore, Terry M.
name: Brown, Adrienne
name: Zeleznik-Le, Nancy J.
name: Schwartz, Benjamin D.
name: Ting, Jenny Pan Yun
name: MacDonald, Gene
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1994

description: Interferon gamma (IFN-gamma) is the most potent inducer of class II major histocompatibility complex (MHC) genes. This induction is uniquely mediated by three DNA elements in the promoter region of class II MHC genes. One of these DNA elements, Y, contains an inverted CCAAT box. Previously, we have screened a lambda gt11 library for Y-binding proteins and identified the YB-1 gene. Here we provide evidence that YB- 1 can repress the IFN-gamma induction of class II MHC promoter as well as the Invariant chain (Ii) gene which also contains a Y element in its promoter. This was demonstrated by cotransfecting a YB-1 expression vector with promoter-reporter gene constructs. As an alternate approach, an efficient transient transfection system was developed which resulted in a > 70% transfection efficiency. Transfection of YB-1 by this procedure resulted in the near abrogation of IFN-gamma induced HLA-DR antigen and mRNA expression. These findings show the functional suppression of class II MHC gene induction by the YB-1 protein.
Кибернаучный коммунизм, или чем дышит «Новая Ленинка»
Creators: name: Семячкин Дмитрий Александрович
Publisher: name: Университетская книга
Year: 2013

description: В ответ на инициативы Правительства РФ и Минобр­науки России и в полном соответствии с мировыми трендами в нашей стране начали появляться проекты открытого доступа к источникам научной информации. Одним из первых ресурсов подобного рода, с самого начала серьёзно заявившим о себе, стала электронная библиотека «КиберЛенинка». О проекте рассказывает Дмитрий Семячкин, автор и руководитель ресурса.
STUDIES ON BRYOZOA (POLYZOA) OF THE BAY OF FUNDY REGION. I. BRYOZOA FROM THE INTERTIDAL ZONE OF MINAS BASIN AND BAY OF FUNDY
Creators: name: POWELL, N.A.
name: CROWELL, G.D.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1967

description: Twenty-four species and one variety of Bryozoa are here recorded from the intertidal zone of the Bay of Fundy. Between tides bryozoans are mainly confined to rock pools; one exception, however, is Flustra foliácea (Linnaeus) which thrives on the extensive areas of tidal mud flats in the Minas Basin. Definite substrate preferences are exhibited by the majority of species collected, some occur exclusively on algae, others on stones; only a small number encrust both. The assemblage in toto has an amphi-Atlantic distribution. Three euryhaline species, Electra monostachys (Busk) (two forms, see p. 339), E. crustulenta (Pallas) and Conopeum reticulum (Linnaeus), were found to occur in the Avon River system in the Minas Basin; E. crustulenta being very prevalent. Some previous records ofElectra monostachys from the east coast of North America have been found to apply to E. crustulenta, and Cribrilina cryptooecium Norman is documented from this area for the first time.
NÉMATODES LIBRES MARINS DE ROSCOFF. I. - DESCRIPTION DE CINQ ESPÈCES NOUVELLES
Creators: name: VITIELLO, Pierre
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1967

description: Description of Conuexolaimus teissieri n.sp., Mononcholaimus b re vident atus n.sp., Enoploides longispiculosus n.sp., Theristus (Theristus) roscoffiensis n.sp.,Theristus (Mesotheristus) hirsutus n.sp. Key of species of Theristus {Theristus) with asymmetrical spicula. A new name, Theristus {Theristus) asymetricus, is proposed for Th.{Th.)problematicus Wieser 1956.
Man lernt nie aus? MigrantInnen in der Weiterbildung am Beispiel Ã–sterreichs
Creators: name: Sprung, Annette
Publisher: name: bildungsforschung
Year: 2010

description: MigrantInnen sind in der Weiterbildung unterrepräsentiert, ihre schlechte Position auf dem Arbeitsmarkt lässt jedoch unter anderem einen erhöhten Bildungsbedarf erkennen. Der Beitrag analysiert die Bildungs- und Arbeitsmarktsituation erwachsener MigrantInnen in Österreich und diskutiert Ursachen einer geringen Bildungsbeteiligung. Des Weiteren werden die pädagogisch-wissenschaftliche Auseinandersetzung mit der Thematik reflektiert sowie Fragen zu Migration und Weiterbildung in den Kontext des Lebenslangen Lernens gestellt.
description: bildungsforschung, Bd. 1 (2008): Interkulturelle Bildung
STFT Phase Retrieval: Uniqueness Guarantees and Recovery Algorithms
Creators: name: Jaganathan, Kishore
name: Eldar, Yonina C.
name: Hassibi, Babak
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: Optimization and Control (math.OC)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: The problem of recovering a signal from its Fourier magnitude is of paramount importance in various fields of engineering and applied physics. Due to the absence of Fourier phase information, some form of additional information is required in order to be able to uniquely, efficiently and robustly identify the underlying signal. Inspired by practical methods in optical imaging, we consider the problem of signal reconstruction from the Short-Time Fourier Transform (STFT) magnitude. We first develop conditions under which the STFT magnitude is an almost surely unique signal representation. We then consider a semidefinite relaxation-based algorithm (STliFT) and provide recovery guarantees. Numerical simulations complement our theoretical analysis and provide directions for future work.
description: IEEE Journal of Selected Topics in Signal Processing 2016
(3756) Andrew Chesser
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis
Creators: name: Satoh, Minoru
name: Reeves, Westley H.
name: Reap, Elizabeth
name: Ajmani, Ajay K.
name: Cohen, Philip L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: The Ku autoantigen is a heterodimer of 70- and 80-kD proteins recognized by autoantibodies from patients with systemic lupus erythematosus and related diseases that is the DNA-binding component of a DNA-dependent protein kinase. The catalytic activity of DNA-dependent protein kinase is carried by a 350-kD subunit (p350). In light of the recently described role of Ku in repairing double-strand DNA breaks, we investigated the regulation of Ku and p350 levels in neutrophils, a terminally differentiated cell type destined to undergo apoptosis. Since the appearance of double-strand DNA breaks is characteristic of apoptosis, we were interested in the possibility that Ku might oppose programmed cell death. Analysis of peripheral blood cells by flow cytometry using anti-Ku and anti-p350 monoclonal antibodies revealed that neutrophils were unstained, whereas resting (G0) lymphocytes were positive. The absence of Ku in mature neutrophils was confirmed by Western blotting and enzyme-linked immunosorbent assay for Ku antigen. In contrast, the human promyelocytic leukemia line, HL-60, which undergoes differentiation toward neutrophils after dimethylsulfoxide treatment, was positive for Ku and p350. In view of the short lifespan of neutrophils and the prolonged half-life of Ku and p350 (> 5 d), these data suggested that Ku was actively degraded during myeloid differentiation. Analysis of HL-60 cells by flow cytometry revealed that Ku staining was bimodal. Cells in G1/G0, S, or G2/M were all stained positively, whereas cells with a subdiploid DNA content characteristic of apoptosis were Ku negative. Similar results were obtained with phytohemagglutin-stimulated human lymphocytes. These data suggest that the Ku antigen is actively degraded in both myeloid cells destined to undergo apoptosis and apoptotic lymphocytes, raising the possibility that degradation of Ku may help to prevent the inappropriate repair of fragmented nuclear DNA during apoptosis.
Schiff Base Metal Complexes as Antimicrobial and Anticancer Agents
Creators: name: Jain, Shruti
name: Rana, Manish
name: Sultana, Razia
name: Mehandi, Rabiya
name: Rahisuddin
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: The Schiff bases known as privileged ligands in organic chemistry are formed by the condensation of a primary amine with a carbonyl group of aldehyde/ketone. Due to their chelating properties and ability to coordinate with a wide range of transition metal ions of various oxidation states, they are considered a significant family of organic compounds. Because of their wide uses in inorganic, bioinorganic, analytical, material science, and pharmaceutical chemistry, Schiff bases and their metal complexes have sparked a lot of interest. The review starts with an overview of Schiff bases and their metal complexes. It highlights the biological activities given by Schiff base ligands and metal complexes (antimicrobial activities and anticancer activities). The use of metallodrugs has proven to be a successful method in anticancer and antimicrobial treatment, and it has the potential to be utilized to treat multidrug-resistant illnesses. Because anticancer and antimicrobial targets are different, Schiff bases can be structurally changed to generate the desired molecule, targeting a specific disease.
Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter
Creators: name: Trowsdale, John
name: Ting, Jenny P.Y.
name: Kelly, Adrian
name: White, Leigh C.
name: Wright, Kenneth L.
name: Beck, Stephan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Recently, four genes (TAP1, TAP2, LMP2, LMP7) involved or potentially involved in the processing and transport of major histocompatibility complex class I-associated antigen to the endoplasmic reticulum have been identified. We now report the initial characterization of the bidirectional promoter for the human transporter associated with antigen processing 1 (TAP1) and low molecular mass polypeptide 2 (LMP2) genes. These genes are divergently transcribed from a central promoter region of only 593 bp. Functional analysis using a bidirectional reporter system demonstrates the minimal 593-bp promoter is sufficient for concurrent expression in both directions. There is no TATA box homology at either end but there is a prevalence of GC boxes. Transcription is initiated at multiple sites for each gene without any of the TAP1 transcripts overlapping with the LMP2 transcripts. The region proximal to the TAP1 gene is required for maximal basal level expression of not only TAP1 but also LMP2. Furthermore, this region is necessary for tumor necrosis factor alpha (TNF-alpha) induction of both genes. Site-specific mutations of an NF-kappa B element in the TAP1 proximal region blocked induction by TNF-alpha in both the TAP1 and LMP2 directions. An adjacent GC box was required for basal expression of both genes as well as augmenting the TNF-alpha induction of the distal LMP2 gene. In vivo genomic foot-printing of this region revealed strong protein/DNA interactions at the NF-kappa B and GC box consensus sequences. In vitro binding studies confirmed the capacity of the NF- kappa B site to bind p50/p65 and p52/p65 heterodimers and of the GC box to bind Sp1. Thus, the promoter elements proximal to the TAP1 gene play a significant role in regulating basal and induced expression of both TAP1 and LMP2. The findings presented in this report clearly link LMP2 expression with TAP1 expression and provide additional suggestive evidence linking LMP2 to class I antigen presentation.
Qualitätskultur für bessere Bildung. Hochschulen auf dem Weg von einer Kontroll- zu einer Qualitätskultur [Einzelbeitrag]
Creators: name: Ehlers, Ulf-Daniel
Publisher: name: bildungsforschung
Year: 2010

description: In diesem Artikel wird argumentiert, dass Qualitätsentwicklung im Bildungsbereich weiter greifen muss, als lediglich Prozesse, Regeln und Abläufe zu Zwecken des Qualitätsmanagements zu definieren. Qualitätsentwicklung muss viel eher das Fördern einer Qualitätskultur als Ziel in den Blick nehmen, welche es den einzelnen Akteuren ermöglicht, ihre Kompetenzen im Rahmen einer (lernenden) Organisation kontinuierlich weiter zu entwickeln. Während dieses Verständnis, Qualität als Teil der Organisationskultur zu verstehen, in der Qualitätsdebatte an Bedeutung gewinnt, mangelt es bislang an grundlegender Forschung und konzeptuellem Verständnis des Phänomens „Qualitätskultur“ in Bildungsorganisationen. Dieser Artikel zielt darauf ab, die Grundlage für ein umfassendes Verständnis von „Qualitätskultur“ im Bildungsbereich zu diskutieren. Der aktuelle Stand der wissenschaftlichen Forschung wird aufgearbeitet und ein Modell von Qualitätskultur entwickelt.
description: bildungsforschung, Bd. 1 (2008): Interkulturelle Bildung
Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I
Creators: name: Eisenberg, Robert A.
name: Maldonado, Michael A.
name: Cohen, Philip L.
name: Roper, Ellen
name: Kotzinr, Brian L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Mice homozygous for the lpr gene have a defect in fas (CD95), a cell surface receptor that belongs to the tumor necrosis factor receptor family and that mediates apoptosis. This genetic abnormality results in lymphoproliferation characterized by the accumulation of CD4-CD8- (double negative [DN]) T cells, autoantibody production, and background strain-dependent, end-organ disease. Our previous results suggested that major histocompatibility complex (MHC) class I may be involved in the development of DN cells. To test this hypothesis, we derived C57BL/6-lpr/lpr (B6/lpr) mice that were deficient for the beta 2- microglobulin gene (beta 2m lpr) and had no detectable class I expression. At 6 mo of age, compared with B6/lpr littermates with normal class I genes, these mice showed greatly reduced lymphadenopathy, mostly due to a dramatic decrease in the number of DN cells. Significant changes in the percentage of other T cell subsets were noted, but only gamma/delta+ T cells showed a marked increase in both percentage and absolute numbers. Analysis of T cell receptor V beta expression of the remaining DN T cells in beta 2m -lpr mice showed a shift to a CD4-like repertoire from a CD8-like repertoire in control B6/lpr mice, indicating that a small MHC class II selected DN population was unmasked in lpr mice lacking class I. We also found that the production of immunoglobulin G (IgG) autoantibodies (antichromatin and anti-single stranded DNA), total IgG and IgG2a, but not total IgM or IgM rheumatoid factor, was significantly reduced in the beta 2m -lpr mice. This work suggests that >90% of DN T cells in lpr mice are derived from the CD8 lineage and are selected on class I. However, a T cell subset selected on class II and T cells expressing gamma/delta are also affected by the lpr defect and become minor components of the aberrant DN population.
Renal Organic Solute Transporters: Relation to Serum
Creators: name: Anzai, Naohiko
Publisher: name: Faculty of Pharmaceutical Sciences KKU MSU UBU
Year: 2010
Subjects: Urate, Transporter, Hypouricemia, Hyperuricemia, Gout, PDZ

description: Isan Journal ofPharmaceutical Sciences, 6, 1, 1-14