cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Impact of down-regulation of starch branching enzyme IIb in rice by artificial microRNA- and hairpin RNA-mediated RNA silencing
Creators: name: Butardo, Vito
name: Fitzgerald, Melissa A.
name: Bird, Anthony R.
name: Gidley, Michael J.
name: Flanagan, Bernadine M.
name: Larroque, Oscar
name: Resurreccion, Adoracion P.
name: Hunter, K. C.
name: Laidlaw, Stephen A.
name: Jobling, Matthew K.
name: Rahman, Sadequr
Publisher: name: Swinburne
Year: 2024

description: The inactivation of starch branching IIb (SBEIIb) in rice is traditionally associated with elevated apparent amylose content, increased peak gelatinization temperature, and a decreased proportion of short amylopectin branches. To elucidate further the structural and functional role of this enzyme, the phenotypic effects of down-regulating SBEIIb expression in rice endosperm were characterized by artificial microRNA (amiRNA) and hairpin RNA (hp-RNA) gene silencing. The results showed that RNA silencing of SBEIIb expression in rice grains did not affect the expression of other major isoforms of starch branching enzymes or starch synthases. Structural analyses of debranched starch
showed that the doubling of apparent amylose content was not due to an increase in the relative proportion of amylose chains but instead was due to significantly elevated levels of long amylopectin and intermediate chains. Rices altered by the amiRNA technique produced a more extreme starch phenotype than those modified using the hp-RNA technique, with a greater increase in the proportion of long amylopectin and intermediate chains. The more pronounced starch structural modifications produced in the amiRNA lines led to more severe alterations in starch granule morphology and crystallinity as well as digestibility of freshly cooked grains. The potential role of
attenuating SBEIIb expression in generating starch with elevated levels of resistant starch and lower glycaemic index is discussed.
Evaluating the Feasibility of Building Refugee Shelters with 3D Printing Technology in the Middle East, Through BIM Design & Simulation Platform
Creators: name: Akeila, Mohanad
Publisher: name: Swinburne
Year: 2024

description: The research is investigated the response of emergency sheltering providers by integrating high innovative technology (3D printing) for constructing refugee's shelters in the Middle East through design performance model that is built up on standards, and codes developed to meet both middle east refugee design requirement as well as emergency shelter provider design requirements. The technology found to be efficient in term of construction time, and construction cost. The printed shelters found to be more stable than standard refugee tents. The printed shelter provided high level of thermal insulation, reduced construction waste, and achieved high level of energy conservations.
The role of the cancer stem cell marker CD271 in DNA damage response and drug resistance of melanoma cells
Creators: name: Redmer, T.
name: Walz, I.
name: Klinger, B.
name: Khouja, S.
name: Welte, Y.
name: Schaefer, R.
name: Regenbrecht, C.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Several lines of evidence have suggested that stemness and acquired resistance to targeted inhibitors or chemotherapeutics are mechanistically linked. Here we observed high cell surface and total levels of nerve growth factor receptor/CD271, a marker of melanoma-initiating cells, in sub-populations of chemoresistant cell lines. CD271 expression was increased in drug-sensitive cells but not resistant cells in response to DNA-damaging chemotherapeutics etoposide, fotemustine and cisplatin. Comparative analysis of melanoma cells engineered to stably express CD271 or a targeting short hairpin RNA by expression profiling provided numerous genes regulated in a CD271-dependent manner. In-depth analysis of CD271-responsive genes uncovered the association of CD271 with regulation of DNA repair components. In addition, gene set enrichment analysis revealed enrichment of CD271-responsive genes in drug- resistant cells, among them DNA repair components. Moreover, our comparative screen identified the fibroblast growth factor 13 (FGF13) as a target of CD271, highly expressed in chemoresistant cells. Further we show that levels of CD271 determine drug response. Knock-down of CD271 in fotemustine-resistant cells decreased expression of FGF13 and at least partly restored sensitivity to fotemustine. Together, we demonstrate that expression of CD271 is responsible for genes associated with DNA repair and drug response. Further, we identified 110 CD271-responsive genes predominantly expressed in melanoma metastases, among them were NEK2, TOP2A and RAD51AP1 as potential drivers of melanoma metastasis. In addition, we provide mechanistic insight in the regulation of CD271 in response to drugs. We found that CD271 is potentially regulated by p53 and in turn is needed for a proper p53-dependent response to DNA-damaging drugs. In summary, we provide for the first time insight in a CD271-associated signaling network connecting CD271 with DNA repair, drug response and metastasis.
Supplementary document for Exceptional coupling in photonic anisotropic metamaterials for extremely low waveguide crosstalk - 4676467.pdf
Creators: name: Mia, Md Borhan
name: Ahmed, Syed Ziauddin
name: Ahmed, Ishtiaque
name: Lee, Yun Jo
name: Qi, Minghao
name: Kim, Sangsik
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Supplemental document
title: Caracterización de las masas de partes blandas en base a su intensidad de señal en RM
Creators: name: Garcia Carballo, Marta
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: MR
subject: Musculoskeletal system

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Describir de forma sistemática la evaluación de las masas de tejidos blandos,
basados en su intensidad de señal en resonancia magnética...
Zločin iz mržnje prema LGBTIQ osobama – Priručnik za žrtve
Creators: name: Jurčić, Marko
name: Dabić, Tea
Publisher: name: Kuća ljudskih prava Zagreb
Year: 2021
Subjects: zločin iz mržnje
LGBTIQ

description: Priručnik daje odgovor na pitanja što je zločin iz mržnje, kome i kako ga prijaviti, koja prava pripadaju žrtvama zločina iz mržnje te koje vrste zaštite stoje na raspolaganju žrtvama zločina iz mržnje u odnosu na njihov specifičan položaj.

Priručnik stavlja naglasak na specifične potrebe pripadnika LGBTIQ zajednice, a namijenjen je osobama koje su same bile metom zločina iz mržnje ili su svjedočile zločinu iz mržnje, kao i stručnim djelatnicima, organizacijama civilnog društva i svim drugim dionicima koji rade ili se u okviru svog djelovanja susreću sa žrtvama zločina iz mržnje.

Uz hrvatski, priručnik je dostupan na engleskom i njemačkom jeziku.
Mesial temporal lobe epilepsy and hippocampal sclerosis associated with BRAFV600E mutant neurons in the Cornu Ammonis: an uncertain pathogenesis and a diagnostic challenge
Creators: name: Alsalek, Samir
name: Himstead, Alexander
name: Self, Scott
name: Fote, Gianna
name: Vadera, Sumeet
name: Monuki, Edwin
name: Perez-Rosendahl, Mari
name: Yong, William
Publisher: name: Free Neuropathology
Year: 2024
Subjects: Hippocampal sclerosis
Epilepsy
BRAF
FANCL
CD34
MTLE
Brain tumor

description: Mesial temporal lobe epilepsy (MTLE) is a common cause of seizures, and hippocampal sclerosis (HS) is the predominant subtype. BRAFV600E mutations in MTLE-HS have only been reported infrequently. Herein, we illustrate the neurologic, radiological, and histopathological details of a patient with MTLE-HS and BRAFV600E mutant neurons. A 31-year-old male with medically refractory epilepsy presented with magnetic resonance imaging (MRI) and electroencephalography (EEG) findings typical of mesial temporal sclerosis without a mass lesion. The surgical specimens showed ILAE Type 1 HS with neurons immunopositive for BRAFV600E mutant protein distributed along the Cornu Ammonis (CA) curvature. Instead of the normal mostly perpendicular orientation of pyramidal neurons relative to the hippocampal surface, the BRAF mutant neurons were often oriented in a parallel manner. On CD34 immunostaining, sparse clusters or nodules of CD34+ stellate cells and single immunopositive stellate cells were identified. BRAFV600E or CD34 immunopositive cells were less than 1 % of total cells. The patient responded well to surgery with no further seizures after 2 years and occasional auras. Hippocampal BRAF mutant non-expansive lesion (HBNL) has been used to describe such lesions with preserved cytoarchitecture and without overt tumor mass. Others may argue for the dual pathology of HS with early ganglioglioma. Whether pre-neoplastic lesions or early tumors, these cases are important for understanding early glioneuronal tumorigenesis and suggest that BRAFV600E studies should be routinely performed on MTLE-HS cases in the setting of clinical trials. With next-generation sequencing, a FANCL deletion was detected in almost half of the alleles in our case, suggesting that many of the histologically normal-appearing cells of the hippocampus contain this alteration. FANCL mutations can result in cytogenetic anomalies and defective DNA repair and therefore may underlie the development of a low frequency BRAF alteration.
description: Free Neuropathology, Bd. 5 (2024)
title: La ecografía en el paciente trasplantado de riñón que no evoluciona bien…¿qué tengo que buscar?
Creators: name: García Roch, Carmen
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Kidney
subject: Ultrasound
subject: Ultrasound-Colour Doppler
subject: Complications
subject: Contrast agent-intravenous
subject: Transplantation

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Revisión de las complicaciones agudas y crónicas sobre el injerto en el paciente con trasplante renal mediante ecografía,
ecografía Doppler y ecografía con contraste...
Role of Cystathionine Gamma-Lyase in Immediate Renal Impairment and Inflammatory Response in Acute Ischemic Kidney Injury
Creators: name: Marko, Lajos
name: Szijarto, Istvan A.
name: Filipovic, Milos R.
name: Kassmann, Mario
name: Balogh, Andras
name: Park, Joon-Keun
name: Przybyl, Lukasz
name: N'diaye, Gabriele
name: Kramer, Stephanie
name: Anders, Juliane
name: Ishii, Isao
name: Mueller, Dominik N.
name: Gollasch, Maik
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Hydrogen sulfide (H2S) is known to act protectively during renal ischemia/reperfusion injury (IRI). However, the role of the endogenous H2S in acute kidney injury (AKI) is largely unclear. Here, we analyzed the role of cystathionine gamma-lyase (CTH) in acute renal IRI using CTH-deficient (Cth−/−) mice whose renal H2S levels were approximately 50% of control (wild- type) mice. Although levels of serum creatinine and renal expression of AKI marker proteins were equivalent between Cth−/− and control mice, histological analysis revealed that IRI caused less renal tubular damage in Cth−/− mice. Flow cytometric analysis revealed that renal population of infiltrated granulocytes/macrophages was equivalent in these mice. However, renal expression levels of certain inflammatory cytokines/adhesion molecules believed to play a role in IRI were found to be lower after IRI only in Cth−/− mice. Our results indicate that the systemic CTH loss does not deteriorate but rather ameliorates the immediate AKI outcome probably due to reduced inflammatory responses in the kidney. The renal expression of CTH and other H2S-producing enzymes was markedly suppressed after IRI, which could be an integrated adaptive response for renal cell protection.
The Effects of TOGETHER: A Contextually Responsive and Collaborative Parent–Educator Program for Teaching Social and Emotional Skills in Young Children
Creators: name: Phillips, Joanna Grace
Publisher: name: Swinburne
Year: 2024

description: This research examines the effects of an early intervention program named TOEGTHER: Growing Children's social and emotional skills. Many early-intervention programs have limited opportunities to develop parent -educator partnerships or cater for the diverse contexts of families. Therefore, the program is designed to help teachers, educators, and parents to grow children's social and emotional skills in a collaborative and contextually responsive way. This research has established a new intervention which develops collaborative partnerships based on understanding the family's individual context. The program's approach helps to ensure that early-intervention programs for teaching social and emotional skills to young children are inclusive and successful for all.
DICER1 hotspot mutations in ovarian gynandroblastoma
Creators: name: Wang, Yemin
name: Karnezis, Anthony N.
name: Magrill, Jamie
name: Tessier-Cloutier, Basile
name: Lum, Amy
name: Senz, Janine
name: Gilks, C. Blake
name: Glenn, McCluggage
name: Huntsman, David G.
name: Kommoss, Friedrich
Publisher: name: The University of British Columbia
Year: 2019

description: AIMS: Gynandroblastoma is a rare ovarian sex cord-stromal tumor characterized by the presence of both male (Sertoli and/or Leydig cells) and female (granulosa cells) components. We investigated the mutational status of DICER1, FOXL2 and AKT1 genes at hotspot regions that are known to be the key driving events in the development of Sertoli-Leydig cell tumor (SLCT), adult granulosa cell tumor (aGCT) and juvenile granulosa cell tumor (jGCT), respectively, to gain insights into the molecular pathogenesis of gynandroblastoma. METHODS AND RESULTS: Sixteen cases of gynandroblastoma were studied. All contained SLCT or Sertoli cell tumor components. aGCT and jGCT components were identified in seven and ten cases, respectively, with one presenting both components. Heterozygous hotspot mutations in the RNase IIIb domain of DICER1 were discovered in three cases including one case with heterologous mucinous elements, all of which were composed of moderately or poorly differentiated SLCT and jGCT components, and harbored the mutations in both histologic components. None of the sixteen cases displayed mutations at the p.C134W (c.402CàG) of FOXL2 or within the pleckstrin-homology domain of AKT1. All cases showed FOXL2 immunostaining in both male and female components. CONCLUSION: DICER1 hotspot mutation is the key-driving event in a subset of gynandroblastomas containing components of SLCT and jGCT. Gynandroblastomas composed of SLCT and jGCT may represent the morphological variants of SLCT. The molecular basis of gynandroblastoma containing a component of aGCT is different from pure aGCT.
Biophysical and biochemical properties of the mammalian male germ cell specific sulfogalactosylglycerolipid (SGG): Contribution to the structure and zona pellucida affinity of pig sperm raft membranes
Creators: name: Bou Khalil, Maroun
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Biology, Cell.
subject: Chemistry, Biochemistry.

description: Raft membranes are implicated in cell adhesion. Here, we demonstrated that rafts isolated from hypermotile capacitated pig sperm as low-density Triton X-100 insoluble membranes had the ability to bind specifically to homologous zonae pellucidae (ZP). This binding was dependent on pig ZP3alpha sulfoglycoprotein, a major player in intact sperm binding. The male germ cell specific sulfogalactosylglycerolipid (SGG) was a sperm raft component and participated in sperm raft-ZP binding, since rafts pretreated with anti-SGG IgG/Fab had decreased ability to bind to the ZP dose dependently. SGG may also partake in raft formation. Fourier transform infrared (FTIR) spectroscopic studies of mixed SGG-cholesterol liposomes revealed that the sulfoglycolipid interacted with cholesterol (a significant raft component) via intermolecular hydrogen bonding. Moreover, mixtures of SGG and cholesterol were insoluble in 1--2% Triton X-100. Since cholesterol is significant for raft formation and since sperm capacitation is associated with cholesterol efflux, we determined whether raft levels in capacitated sperm were the same as those in control sperm. Interestingly, our results revealed an increase in raft levels in the capacitated sperm, as well as an enhanced ZP affinity of these membrane domains, compared to those of control sperm. These results corroborated the implication of rafts in cell adhesion and strongly suggested that the enhanced ZP-binding ability of capacitated sperm may be attributed to increased levels of sperm rafts, with a greater affinity for the ZP.
Quantitative detection of DNMT3A R882H mutation in acute myeloid leukemia
Creators: name: Berenstein, Rimma
name: Blau, Igor Wolfgang
name: Suckert, Nikola
name: Baldus, Claudia
name: Pezzutto, Antonio
name: Dörken, Bernd
name: Blau, Olga
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: AML
subject: DNMT3A mutations
subject: Quantitative PCR
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Background DNMT3A mutations represent one of the most frequent gene alterations detectable in acute myeloid leukemia (AML) with normal karyotype. Although various recurrent somatic mutations of DNMT3A have been described, the most common mutation is located at R882 in the methyltransferase domain of the gene. Because of their prognostic significance and high stability during disease evolution, DNMT3A mutations might represent highly informative biomarkers for prognosis and outcome of disease. Methods We describe an allele-specific PCR with a Blocking reagent for the quantitative detection of DNMT3A R882H mutation providing the possibility to analyze the quantitative amount of mutation during the course of disease. Next, we analyzed 62 follow- up samples from 6 AML patients after therapy and allogeneic stem cell transplantation (alloSCT). Results We developed an ASB-PCR assay for quantitative analysis of R882H DNMT3A mutation. After optimization of blocker concentration, a R882H-positive plasmid was constructed to enhance the accuracy of the sensitivity of quantitative detection. The assay displayed a high efficiency and sensitivity up to 10−3. The reproducibility of assay analyzed using follow-up samples showed the standard deviation less than 3.1 %. This assay displayed a complete concordance with sequencing and endonuclease restriction analysis. We have found persistence of DNMT3A R882H mutations in complete remission (CR) after standard cytoreduction therapy that could be indicating presence of DNMT3A mutation in early pre-leukemic stem cells that resist chemotherapy. The loss of correlation between NPM1 and DNMT3A in CR could be associated with evolution of pre-leukemic and leukemic clones. In patients with CR with complete donor chimerism after alloSCT, we have found no DNMT3A R882H. In relapsed patients, all samples showed an increasing of both NPM1 and DNMT3A mutated alleles. This suggests at least in part the presence of NPM1 and DNMT3A mutations in the same cell clone. Conclusion We developed a rapid and reliable method for quantitative detection of DNMT3A R882H mutations in AML patients. Quantitative detection of DNMT3A R882H mutations at different time points of AML disease enables screening of follow-up samples. This could provide additional information about the role of DNMT3A mutations in development and progression of AML.
Use of nanomaterials and nanoscale products for wastewater treatment
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: subject: Nanomaterialien
subject: Nanotechnik
subject: Abwasserbehandlung
subject: Nanopartikel
subject: nanomaterials
subject: nanotechnology
subject: nanotechniques
subject: waste water treatment
subject: water treatment
subject: nanoparticle
subject: Water

description: The treatment of contaminated water prior to its introduction into surface water is one of the most pressing global challenges of the future. Existing processes for treating water and wastewater can be optimized by suitable nanotechnology applications, which can result in a more targeted removal of contaminants, better energy efficiency and lower costs. Experts predict that the water sector could also benefit most from innovative nanotechnology applications in the medium to long term. In addition to the benefits of using nanomaterials for water treatment, it should also be borne in mind that nanomaterials can have unintended impacts on the environment and human health. When using nanomaterials it is important to note that the novel properties of nanomaterials may possibly also have harmful effects on the environment and humans.
Investigating the impact of self-as-a-model interventions on children's self-regulation of learning, swimming performance, and thought processes.
Creators: name: Clark Larkin, Shannon.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Education, Physical.

description: This study compared the impact of a self-modeling intervention (viewing oneself perform an adaptive behavior) and practice, a self-observation intervention (viewing oneself perform at current skill level) and practice or practice alone on children's self-regulation of learning, anxiety, swimming performance and thought processes. A mixed methodology approach was employed as both qualitative and quantitative data were obtained. The quantitative component operated within Zimmerman's (1989, 2000) theory of self-regulated learning, and as such four self-regulatory processes (self-efficacy, motivation, self-satisfaction, and goal setting), as well as anxiety and physical performance were examined. For the qualitative component, the current study employed a think-aloud protocol (Ericsson & Simon, 1996) with the goal of understanding the thought processes that unfolded when children viewed self-modeling and self-observation videos. Thirty-three children, between the ages of six and ten (mean age = 8.3 years), were randomly assigned to a self-modeling group, a self-observation group or a control group. The children participated in an eight-day swimming intervention program. The analyses with the quantitative data showed consistently that the self-modeling group obtained superior scores on the measures examining the self-regulatory processes and physical performance as compared to both the self-observation group and the control group, with these two groups performing similarly. These results provide support for the implementation of self-modeling interventions with children learning motor skills. The analysis of the verbal protocols clearly showed that the majority of the children's verbalizations were self-evaluative in both a positive (Descriptive Positive), and negative (Descriptive Negative) direction, as well as, being related to future skill improvement (Prescriptive). These finding are discussed in terms of how they relate to Bandura's social cognitive theory of modeling (1977, 1986, 1997). A comparison revealed very few differences between the self-modeling and the self-observation interventions, suggesting that children appear to be gaining information about their skill performance and what to do to improve their next performance attempts regardless of the type of intervention.
Intrinsic immune mechanisms restricting human cytomegalovirus replication
Creators: name: Schilling, Eva-Maria
name: Scherer, Myriam
name: Stamminger, Thomas
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: restriction factor
subject: intrinsic immunity
subject: DDC 610 / Medicine & health
subject: Cytomegalovirus; Immunology
subject: Antiviral restriction factors
subject: Cytomegalie-Virus

description: Cellular restriction factors (RFs) act as important constitutive innate immune barriers against viruses. In 2006, the promyelocytic leukemia protein was described as the first RF against human cytomegalovirus (HCMV) infection which is antagonized by the viral immediate early protein IE1. Since then, at least 15 additional RFs against HCMV have been identified, including the chromatin regulatory protein SPOC1, the cytidine deaminase APOBEC3A and the dNTP triphosphohydrolase SAMHD1. These RFs affect distinct steps of the viral replication cycle such as viral entry, gene expression, the synthesis of progeny DNA or egress. This review summarizes our current knowledge on intrinsic immune mechanisms restricting HCMV replication as well as on the viral strategies to counteract the inhibitory effects of RFs. Detailed knowledge on the interplay between host RFs and antagonizing viral factors will be fundamental to develop new approaches to combat HCMV infection.
Cognitive service virtualisation: An automatic and adaptive method to virtualise software services
Creators: name: Farahmandpour, Zeinab
Publisher: name: Swinburne
Year: 2024

description: Software services communicate with different requisite services over the computer network to accomplish their tasks. The requisite services may not be readily available to test a specific service. Thus, service virtualisation has been proposed as an industry solution to ensure availability of the interactive behaviour of the requisite services. However, the existing techniques of virtualisation cannot satisfy the required accuracy or time constraints to keep up with the competitive business world. These constraints sacrifices quality and testing coverage, thereby delaying the delivery of software. We proposed a novel technique to improve the accuracy of the existing service virtualisation solutions without sacrificing time. This method generates the service response and predicts fields in virtualised responses, extending existing research with lower complexity and higher accuracy. The experimental evaluation illustrates that the proposed approach can generate responses with the required fields and accurate values for both categorical and numerical fields over four data sets with stateful nature.
Supplementary document for Magneto-refractive Second Harmonic Generation from Plasmonic Antennas in the Mid-infrared - 4678615.pdf
Creators: name: Razdolski, Ilya
name: Armelles, Gaspar
name: Cebollada, Alfonso
name: Kirilyuk, Andrei
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Detailed schematic of the experimental setup.
Supplementary document for Magneto-refractive Second Harmonic Generation from Plasmonic Antennas in the Mid-infrared - 4678615.pdf
Creators: name: Razdolski, Ilya
name: Armelles, Gaspar
name: Cebollada, Alfonso
name: Kirilyuk, Andrei
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Detailed schematic of the experimental setup.
Modeling Lean and Agile Approaches: A Western Canadian Forest Company Case Study
Creators: name: Vergara, Francisco P.
name: Palma, Cristian D.
name: Nelson, John
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: In the forest supply chain of the coast of British Columbia, the material flows are directed toward the push production of commodity products. This industry has not adopted lean and agile principles due to unclear economic impacts on the supply chain in changing market conditions. We tested the ability of lean and agile principles to improve performance in the coastal integrated forest industry. Mixed integer programming formulations were subject to over–under production capacity, and over–under demand fulfillment penalties to emulate agile, lean, and hybrid manufacturing environments, when solving the planning problem. Assuming that the coastal integrated forest industry performs as a hybrid environment, the profit results of each manufacturing environment were judged. The results show that, opportunities for profit improvement were 11% for adopting an agile environment when demand was stable with low variation and large batches of production. However, profit improvement was non-existent when the same demand attributes apply but with high variation. The opportunities for profit improvement were 12% when an agile environment or lean environment was adopted when demand was stable with low variation and small batches of production. However, opportunities for profit improvements of 15% existed for adopting an agile environment when demand was unstable with high variation and small batches of production.
Functional analysis of amylase gene promoters in Drosophila melanogaster.
Creators: name: Loverre-Chyurlia, Ada.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Biology, Molecular.

description: We were able to demonstrate that amylase genes carrying short promoter sequences are still fully functional and show their characteristic pattern of glucose repression in transformed larvae. Amy (amylase) promoter sequences linked to the coding sequences of unrelated genes, the luciferase gene of the firefly, or the Adh (alcohol dehydrogenase) gene of D. melanogaster, mediate a pattern of tissue-specificity and glucose repression typical of amylase. A reciprocal gene construct, in which Amy coding sequences are controlled by upstream sequences of the Adh gene (Adh-Amy hybrid construct) confirmed that Amy coding sequences do not contribute to glucose repression or tissue-specificity. Amylase promoter sequences were further analyzed in order to localize promoter elements mediating expression and glucose repression. A deletion analysis and site-directed mutagenesis of the Amy-1 proximal gene showed that 109 bp of upstream sequences are sufficient for full expression, and that a sequence element essential for gene expression is present between $-$109 and $-$82; no single region was found to be responsible for glucose repression in these tests indicating the possibility that multiple elements mediate the glucose response. The study of the distal amylase gene indicated that a short promoter sequence is also sufficient to control expression of this gene. A deletion analysis combined with DNA sequence comparisons revealed similarities between the proximal and distal promoters, although with some variation in the position of sequence elements important for gene expression. The DNA sequence comparison of the coding regions of proximal and distal amylase genes from the same chromosome allowed us to uncover unexpectedly high levels of nucleotide similarity, suggesting the occurrence of concerted evolution. (Abstract shortened by UMI.)
Supplementary document for Injection-seeded single-longitudinal-mode Ti:Sapphire Laser with no active stabilization - 4679238.pdf
Creators: name: Marienko, Igor
name: Sokolov, Alexei
name: zhi, miaochan
name: Khizhnyak, Anatoliy
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Lasers and Quantum Electronics

description: Fig. S1.
Fish Protection and Downstream Fish Migration in Dialog - The "Forum Fish Protection and Downstream Fish Migration"
Creators: name: Naumann, Stephan
name: Heimerl, Stephan
Publisher: name: My University
Year: 2013

description: The item of fish protection and downstream fish migration has been the subject discussions about environmental politics, environmental law and professional items for quite some time, and its intensity has increased in recent years. This was the reason to establish the "Forum fish protection and downstream fish migration". The fundamental objective within the period 2012 to 2014 to have an open exchange on the various aspects of the topic and to promote a common, nationwide uniform understanding about the demands and solutions in the current state of knowledge and technology have to be taken into account for fish protection and downstream fish migration and for conservation and establishment of fish populations. In this paper, the current status of this process is described.Quelle: Scopus.com
Correlating intrusion alerts with unsupervised learning
Creators: name: Smith, Reuben
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Computer Science.

description: Alert correlation systems attempt to discover the relationships between intrusion detection system (IDS) alerts to determine the motivation of attackers. IDSs are deployed to detect computer attacks against a network, but the output of IDSs is considered low level since a single attack can be represented by several alerts. An alert correlation system enables the intrusion analyst to find important alerts and filter false positives more efficiently. We present an alert correlation system based on unsupervised machine learning algorithms that is accurate and low maintenance. The system is implemented in two stages of correlation. At the first stage of correlation alerts are grouped together such that each group forms one step of an attack. At the second stage the groups created at the first stage are combined such that each combination of groups contains the alerts of precisely one full attack. (Abstract shortened by UMI.)
Umweltverträgliche Standortsteuerung von Solar-Freiflächenanlagen
Creators: name: Günnewig, Dieter
name: Johannwerner, Esther
name: Metzger, Jochen
Publisher: name: Umweltbundesamt
Year: 2022
Subjects: subject: Solarenergie
subject: Photovoltaik
subject: Flächenkulisse
subject: Kriterien Erneuerbare-Energien-Gesetz (EEG)
subject: Klima | Energie

description: Die Szenarien der Energiewende lassen erwarten, dass bis 2030 knapp 100.000 ha Fläche mit Solar-Freiflächenanlagen bebaut sein werden. Die Handlungsempfehlungen zur umweltverträglichen Steuerung von Solar-Freiflächenanlagen richten sich an Planer*innen und Entscheidungsträger*innen, die für die räumlichen Erfordernisse einer erfolgreichen Energiewende Verantwortung tragen. Sie bieten Ansätze und Kriterien für die Regionalisierung der Ausbauziele, die Schaffung und Sicherung der Akzeptanz vor Ort und die aktive, umweltverträgliche Standortsteuerung von Solar-Freiflächenanlagen. So sollen die Instrumente der regionalen Raumordnung und der Bauleitplanung flankiert von Landschaftsplänen und Umweltprüfungen, mit fachlichem und methodischem Knowhow dafür Sorge tragen, dass die Energiewende umwelt- und landschaftsverträglich erfolgen kann. Quelle: www.umweltbundesamt.de
description: Die Szenarien der Energiewende lassen erwarten, dass bis 2030 knapp 100.000 ha Fläche mit Solar-Freiflächenanlagen bebaut sein werden. Die Handlungsempfehlungen zur umweltverträglichen Steuerung von Solar-Freiflächenanlagen richten sich an Planer*innen und Entscheidungsträger*innen, die für die räumlichen Erfordernisse einer erfolgreichen Energiewende Verantwortung tragen. Sie bieten Ansätze und Kriterien für die Regionalisierung der Ausbauziele, die Schaffung und Sicherung der Akzeptanz vor Ort und die aktive, umweltverträgliche Standortsteuerung von Solar-Freiflächenanlagen. So sollen die Instrumente der regionalen ⁠Raumordnung⁠ und der ⁠Bauleitplanung⁠, flankiert von Landschaftsplänen und Umweltprüfungen, mit fachlichem und methodischem Knowhow dafür Sorge tragen, dass die Energiewende umwelt- und landschaftsverträglich erfolgen kann.
Salvator Mundi: die Entdeckung der JUPITERMONDE durch Leonardo, Dürer und Giorgione
Creators: name: Keim, Frank
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: Kristallkugel
subject: Geschichte 1501
subject: Rosenkranzfest
subject: Johannes de Sacrobosco
subject: Nürnberg
subject: Castelfranco
subject: Florenz
subject: Astronomie 16. Jh.
subject: Sphaera Mundi
subject: Casa Marta-Pellizzari (Castelfranco Veneto)
subject: Christie's International P.L.C.
subject: Luini, Bernardino
subject: Giampietrino
subject: Sesto, Cesare da
subject: Carpaccio, Vittore
subject: Jupiter
subject: Saturn
subject: Mars
subject: Hochrenaissance
subject: DDC 500 / Natural sciences & mathematics
subject: Astronomy in art
subject: Art, Renaissance
subject: Jupiter (Planet); Satellites
subject: Astronomy; 16th century
subject: Dürer, Albrecht 1471-1528
subject: Leonardo, da Vinci 1452-1519
subject: Giorgione 1477-1511
subject: Salvator mundi
subject: Astronomie
subject: Jupitermond
subject: Renaissance
subject: Kunst
subject: Wissenschaft

description: On November 15 2017 the painting Salvator Mundi („Savior of the World“) attributed to Leonardo at a Christie’s auction was sold for the price of $400 million, the highest price ever paid for a work of art. This paper will argue what constitutes the actual value of the masterpiece. Albrecht Duerer’s unfinished Salvator Mundi was created between 1502 and 1505. A thorough check of the painting gave insight that Duerer discovered Jupiter’s large moons in the same period of time as Leonardo and Giorgione. Together with the latter he even discovered a third moon - Europa.- In the second chapter it is shown how Leonardo’s successors took on and modified his work. The copies by Giampietrino, da Sesto and Luini will be analyzed. Leonardo exerted an influence on Carpaccio’s Salvator, which considers the possibility of a „moving“ earth. The fact that there are four satellites of Jupiter became an irrevocable certainty.
Identifying and characterizing agents in soy that have a potential role in diabetes development.
Creators: name: Rastegar, Shila.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Agriculture, Animal Culture and Nutrition.

description: To examine which component(s) of soy proteins are diabetogenic, studies were designed to look at diabetes-related soy protein fractions. In a study of diabetes-prone and control BB (BioBreeding) rats, sera from BBc (non-diabetes-prone), BBdp (diabetes-prone), BBd-U (diabetic untreated) and BBd-T (diabetic insulin-treated) rats at different risk of developing diabetes were tested against the proteins extracted from different soy protein sources. A diabetes-related protein designated S10 was identified and reactivity against two protective bands designated S6 and S13 was associated with less risk of developing diabetes. Two separate cross sectional and prospective (blood samples collected at 45 d, 70 d and 149 d or at diagnosis) studies were carried out. Western blotting results in both studies confirmed that high S10 reactivity in the pre-diabetic period was associated with diabetes. Overall Western blot analyses showed interestingly that two soy protein-fractions, S6 and S13, were related to resistance and reactivity against these two fractions may be protective and the S10 soy protein fraction appears to be highly diabetes-related and associated with diabetes. In studies using human serum, two sets of blood samples from newly diagnosed diabetic children showed the same association for the S10 soy protein fraction. Early oral dosing with soybean meal delayed the onset of diabetes and protected some of the animals from developing the disease. Pre-absorption studies showed there was an overall reduction in reactivity to soy antigens using pre-absorbed sera. This indicated some cross reactivity between food antigens and RIN cell proteins. (Abstract shortened by UMI.)
The Development of Electrospun Conductive Polymer Nanofibres for Gas Sensing Applications
Creators: name: Spiers, Maryanne Ellen
Publisher: name: Swinburne
Year: 2024

description: This thesis describes the process of electrospinning high concentration, high molecular weight polyaniline (PANi) doped with (+)-camphor-10-sulfonic acid (CSA) into nanofibrous membranes, which was facilitated by a novel dissolution method allowing the total solvation of PANI-CSA in common organic solvents. The PANi-CSA nanofibre membranes were subsequently employed as substrates in colorimetric gas sensing, which demonstrated linearity upon exposure to 10-5,650 ppm of ammonia at ambient and high (80 %RH) humidity. Furthermore, the same novel dissolution method was employed to dissolve and electrospin another intractable polymer - polydopamine (PDA) - into novel nanofibre membranes.
Supplementary document for Injection-seeded single-longitudinal-mode Ti:Sapphire Laser with no active stabilization - 4679238.pdf
Creators: name: Marienko, Igor
name: Sokolov, Alexei
name: zhi, miaochan
name: Khizhnyak, Anatoliy
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Lasers and Quantum Electronics

description: Fig. S1.
The Vision of the Fathers of the Last Centuries: Archbishop Averchie Taușev (1906-1976)
Creators: name: Lazăr, Alexandru
Publisher: name: Zenodo
Year: 2025
Subjects: deification
contemporary father
Christian spirituality
unseen battle

description: It is well known that Christian spirituality unanimously affirms that the main goal of the human being is to be deified. All human powers were originally directed towards the attainment of perfection, meaning, towards God. Following the fall into sin, this natural orientation was distorted and the direction of these powers was reoriented towards man and the world. Thus, a „conflict of interests” was created between the original human nature and the nature of the fallen man. The symbiosis of archetypal drive and will is the only way of restoration. This article aims to make the term of “striving” as understandable as possible. It must be understood as the only way to fulfillment and to the acquisition of true happiness that can be found only in God. Only with and through Him can human fulfillment (deification), be achieved. Although dedicated to the contemporary man, the work of Archbishop Averchie often contains negative statements regarding the evolution of the world. In fact, his perspective intends to awaken the modern man, but for some it may be received as a discouragement. Also as a member of ROCOR (Russian Orthodox Church Outside of Russia) and considering the period in which he lived, which was deeply impacted by the consequences of communism, his understanding of the neediness can be accepted.
Entwicklung der spezifischen Kohlendioxid-Emissionen des deutschen Strommix in den Jahren 1990 bis 2012
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2013
Subjects: subject: Strommix
subject: Strom
subject: Kohlendioxid
subject: CO2
subject: Freisetzung von Treibhausgasen
subject: CO2-Ausstoß
subject: Deutschland
subject: Klima | Energie
subject: Climate | Energy

description: Das Umweltbundesamt veröffentlicht jährlich seine Berechnungsergebnisse zur Entwicklung des Kohlendioxid-Emissionsfaktors des deutschen Strommix in der Zeitreihe ab 1990, der als ⁠Indikator⁠ für die Klimaverträglichkeit der Stromerzeugung angesehen werden kann. Die Erzeugung einer Kilowattstunde Strom verursachte 2010 in Deutschland durchschnittlich 546 Gramm ⁠CO2⁠. Mehr erneuerbare Energieträger und der Wechsel zu emissionsarmen Brennstoffen führten zu einem geringeren Wert als im Vorjahr. Für 2011 hat das ⁠UBA⁠ auf der Grundlage vorläufiger Daten jedoch einen gestiegenen „Spezifischen Emissionsfaktor“ von 564 g/kWh errechnet. Grund ist ein Anstieg der aus Kohle gewonnenen Strommenge. Schätzungen für 2012 ergeben derzeit einen Wert von  576 g/kWh.
Identification of SMYD2 interactions and substrates by immunoprecipitation coupled to mass spectrometry
Creators: name: Abu-Farha, Mohamed
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Chemistry, Biochemistry.

description: Very little is known about SMYD2 (SET and MYND containing protein 2), which is a member of the SMYD protein family. However, the interest in better understanding the roles of SMYD2 has grown due to recent reports indicating that SMYD2 methylates p53 and histone H3. I report the cytosolic and nuclear interactome of SMYD2 using a combination of IP-HTMS, ChIP-HTMS and co-immunoprecipitation methods. In particular, I report that SMYD2 interacts with HSP90alpha independently of the SET and MYND domain. The interaction of SMYD2 with HSP90alpha enhances SMYD2 histone methyltransferase activity and specificity for histone H3 at lysine 4 (H3K4) in vitro. Interestingly, histone H3K36 methyltransferase activity is independent of its interaction with HSP90alpha similar to LSD1 dependency on the androgen receptor. I also show that HSP90alpha is methylated by SMYD2 at lysine 209 and 565. Methylation of HSP90alpha is removed by LSD1. We have demonstrated that SMYD2 is being automethylated. Automethylation of SMYD2 is inhibited by the increasing concentration of recombinant SMYD2 in vitro. Even though the function of SMYD2 is still not fully understood, it is clear that it acts as an activator of gene expression as shown by microarray analysis. In this experiment, I have showed using a cDNA microarray that SMYD2 gain of function is correlated with the up-regulation of 37 and down-regulation of 4 genes. The majority of these genes are involved in the cell cycle, chromatin remodeling, and transcriptional regulation. TACC2 is one of the genes up regulated as a result of SMYD2 gain of function. Up-regulation of TACC2 by SMYD2 occurs as a result of SMYD2 binding to the TACC2 promoter where it methylates H3K4. When combined together, the interaction and the gene expression data confirm the suggested role of SMYD2 in DNA damage response.
300 Word Statement, Death, Dinner and Performance Project: A Study of the Efficacy of Performance to Enhance Conversations Around Death and Dying project
Creators: name: McCormick, Sheila
Publisher: name: University of Salford
Year: 2019
Subjects: classificationCode: 360403
subject: Drama, theatre and performance studies

description: 300 Word Statement, Death, Dinner and Performance Project: A Study of the Efficacy of Performance to Enhance Conversations Around Death and Dying project
Do Local Landscape Elements Enhance Individuals’ Place Attachment to New Environments? A Cross-Regional Comparative Study in China
Creators: name: Liu, Qunyue
name: Fu, Weicong
name: Konijnendijk, C. C. (Cecil C.)
name: Xiao, Yiheng
name: Zhu, Zhipeng
name: You, Da
name: Zhu, Nanyan
name: Huang, Qitang
name: Lan, Siren
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Globalization and urbanization have made many Chinese cities lose their distinct characteristics and have led to emotional sense of loss for individuals. Place attachment, as encompassing place dependence and place identity, is the positive emotion that describes the psychological connections between people and a certain place. Many studies have indicated that people develop place attachment toward a certain place by long-term interaction with that place. However, few studies have demonstrated that place attachment might also be evoked by a landscape that looks familiar, but with which a person has not had long-term interactions. It is important to understand the role of place attachment in urban design, as neglecting place attachment can have a negative impact on the outcomes of urban planning and urban design. In this study we explored the contributions of local landscape elements to people’s place attachment to a new physical environment by means of a cross-regional comparative study. Three groups of respondents living in three different areas of China were chosen, and a photo-based approach was used to examine the association between local landscape elements and place attachment. The results indicate, first, that local landscapes positively contribute to residents’ place attachment. Next, an individual’s place attachment to new environments can be enhanced by adding familiar local landscape elements. Findings suggest that planners and designers can build stronger place attachment by integrating landscape elements that are familiar to people. This can have implications, for example, when creating links between newcomers and the new environments to which they have moved.
Proyecto Mary Jo Deegan. Emma Goldman
Creators: name: Navarro-Fosar, María-Rocío
name: Pasero, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: subject: anarchism
subject: direct action
subject: free love
subject: libertarian pedagogy
subject: Marriage
subject: Sexuality
subject: statelessness
subject: women's emancipation

description: Emma Goldman: vida, obras y pensamiento social