cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cuprous oxide-based nanocrystals with combined chemo/chemodynamic therapy to increase tumor drug sensitivity by reducing mitochondria-derived adenosine-triphosphate
Creators: name: He, Haoran
name: Wu, Jiaming
name: Liang, Min
name: Xiao, Yao
name: Wei, Xuejian
name: Cao, Yuqin
name: Chen, Zhiheng
name: Lin, Tian
name: Ye, Miaosheng
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Gastrointestinal (GI) tumor is a serious disease with high mortality rates and morbidity rates worldwide. Chemotherapy is a key treatment for GI, however, systematic side effects and inevitable drug resistance complicate the situation. In the process of therapy, P-glycoprotein (P-gp) could remove chemotherapy drugs from cells, thus causing multi-drug resistance. Chemodynamic therapy (CDT) utilizing Fenton chemistry has been used for cancer therapy, along with various combination therapies. The reactive oxygen species produced by CDT could inhibit P-gp’s efflux pump function, which reduce chemoagents excretion and reverse drug resistance. In the present study, we developed novel nanocrystals (Cu2O@Pt NCs) to overcome drug resistance by reducing mitochondria-derived ATP through chemo/CDT in GI cancer. Furthermore, in vivo results in tumor-bearing mice demonstrated that treatment with Cu2O@Pt NCs with CDT and chemotherapy could achieve the most effective antitumor therapeutic effect with the least amounts of adverse effects. As a result, Cu2O@Pt NCs could provide a promising strategy for chemo/CDT-synergistic therapy.
Original code of the project--"Host-genotype-Dependent Heritable Cecal Microbes are Linked to Metabolites in Chicken Breast Muscle"
Creators: name: Feng, Yuqing
name: Liu, Dan
name: Liu, Yan
name: Yang, Xinyue
name: Zhang, Meihong
name: Wei, Fuxiao
name: Li, Depeng
name: Hu, Yongfei
name: Guo, Yuming
Publisher: name: figshare
Year: 2022
Subjects: subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 70707 Veterinary Microbiology (excl. Virology)
subject: FOS: Veterinary sciences

description: These are the original codes of the project.
Additional files 1: of Knowledge, attitudes and practices on Schistosomiasis in sub-Saharan Africa: a systematic review
Creators: name: Hlengiwe Sacolo
name: Chimbari, Moses
name: Kalinda, Chester
Publisher: name: figshare
Year: 2018
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Quality Assessment of individaul studies. This is a tool that was used for critical appraisal of the studies included in the review. This tool was modified from the initially developed by Downes and Brennan [27] (DOCX 23 kb)
Additional file 1 of d-Borneol enhances cisplatin sensitivity via p21/p27-mediated S-phase arrest and cell apoptosis in non-small cell lung cancer cells and a murine xenograft model
Creators: name: Li, Jinxiu
name: Yuan, Jianmei
name: Li, Yong
name: Wang, Jian
name: Gong, Daoyin
name: Xie, Qian
name: Ma, Rong
name: Wang, Jiajun
name: Ren, Mihong
name: Lu, Danni
name: Xu, Zhuo
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: The STR profiling of A549 cell.
Enhancement of the anticancer effect of atorvastatin-loaded nanoemulsions by improving oral absorption via multivalent intestinal transporter-targeting lipids
Creators: name: Subedi, Laxman
name: Pandey, Prashant
name: Khadka, Bikram
name: Shim, Jung-Hyun
name: Cho, Seung-Sik
name: Kweon, Seho
name: Byun, Youngro
name: Kim, Ki-Taek
name: Park, Jin Woo
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Atorvastatin (ATV) has attracted considerable attention as a potential therapeutic agent for cancer because it inhibits cancer cell proliferation by suppressing the mevalonate pathway. However, because of its low oral absorption, high doses of ATV are required for chemotherapeutic applications. In this study, we constructed ATV-loaded nanoemulsions (ATV-NEs) containing multivalent intestinal transporter-targeting lipids to improve the oral bioavailability of ATV. ATV-NEs were prepared via oil-in-water emulsification for transporter-targeted delivery, and contained the following anchors: an ionic complex of deoxycholic acid (DOCA) with the cationic lipid 1,2-dioleyl-3-trimethylammonium propane (DOTAP) (DOCA-DOTAP), a biotin-conjugated lipid (Biotinyl PE), and d-alpha-tocopherol polyethylene glycol succinate (TPGS) to allow bile acid- and multivitamin transporter-mediated permeation of ATV without P-glycoprotein (P-gp)-mediated efflux. The optimized formulation (ATV-NE#6) had 1,091% higher oral bioavailability than free ATV. Finally, treatment of 4T1 cell-bearing mice with oral ATV-NE#6 (equivalent to 40 mg/kg ATV) significantly suppressed tumor growth; the maximum tumor growth reduction was 2.44-fold that of the control group. The results thus suggest that ATV-NEs allow for effective oral chemotherapy by enhancing the oral bioavailability of ATV.
A new magnetic phase in the nickelate perovskite TlNiO$_3$
Creators: name: Korosec, L.
name: Pikulski, M.
name: Shiroka, T.
name: Medarde, M.
name: Luetkens, H.
name: Alonso, J. A.
name: Ott, H. R.
name: Mesot, J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The RNiO$_3$ perovskites are known to order antiferromagnetically below a material-dependent Néel temperature $T_\text{N}$. We report experimental evidence indicating the existence of a second magnetically-ordered phase in TlNiO$_3$ above $T_\text{N} = 104$ K, obtained using nuclear magnetic resonance and muon spin rotation spectroscopy. The new phase, which persists up to a temperature $T_\text{N}^* = 202$ K, is suppressed by the application of an external magnetic field of approximately 1 T. It is not yet known if such a phase also exists in other perovskite nickelates.
description: 5 pages, 7 figures
Additional file 2: of A systematic review on the use of healthcare services by undocumented migrants in Europe
Creators: name: Winters, Marjolein
name: Rechel, Bernd
name: Jong, Lea De
name: Pavlova, Milena
Publisher: name: figshare
Year: 2018
Subjects: subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: PRISMA checklist. (DOC 58 kb)
"Dandelion" Filament Eruption and Coronal Waves Associated with a Solar Flare on 2011 February 16
Creators: name: Cabezas, Denis P.
name: Martínez, Lurdes M.
name: Buleje, Yovanny J.
name: Ishitsuka, Mutsumi
name: Ishitsuka, José K.
name: Morita, Satoshi
name: Asai, Ayumi
name: UeNo, Satoru
name: Ishii, Takako T.
name: Kitai, Reizaburo
name: Takasao, Shinsuke
name: Yoshinaga, Yusuke
name: Otsuji, Kenichi
name: Shibata, Kazunari
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Coronal disturbances associated with solar flares, such as H$α$ Moreton waves, X-ray waves, and extreme ultraviolet (EUV) coronal waves are discussed herein in relation to magnetohydrodynamics fast-mode waves or shocks in the corona. To understand the mechanism of coronal disturbances, full-disk solar observations with high spatial and temporal resolution over multiple wavelengths are of crucial importance. We observed a filament eruption, whose shape is like a "dandelion", associated with the M1.6 flare that occurred on 2011 February 16 in the H$α$ images taken by the Flare Monitoring Telescope at Ica University, Peru. We derive the three-dimensional velocity field of the erupting filament. We also identify winking filaments that are located far from the flare site in the H$α$ images, whereas no Moreton wave is observed. By comparing the temporal evolution of the winking filaments with those of the coronal wave seen in the extreme ultraviolet images data taken by the Atmospheric Imaging Assembly on board the {\it Solar Dynamics Observatory} and by the Extreme Ultraviolet Imager on board the {\it Solar Terrestrial Relations Observatory-Ahead}, we confirm that the winking filaments were activated by the EUV coronal wave.
description: 21 pages, 9 figures, accepted by The Astrophysical Journal, December 31, 2016
title: ADCO, Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402) (11 H 1160), f. 00481
Creators: name: de la Côte-d'Or, Archives départementales
name: CBMA/CG21/F.PETOT/2017
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160), f. 00481, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Additional file 2 of d-Borneol enhances cisplatin sensitivity via p21/p27-mediated S-phase arrest and cell apoptosis in non-small cell lung cancer cells and a murine xenograft model
Creators: name: Li, Jinxiu
name: Yuan, Jianmei
name: Li, Yong
name: Wang, Jian
name: Gong, Daoyin
name: Xie, Qian
name: Ma, Rong
name: Wang, Jiajun
name: Ren, Mihong
name: Lu, Danni
name: Xu, Zhuo
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: The STR profiling of H460 cell.
Likelihood-free stochastic approximation EM for inference in complex models
Creators: name: Picchini, Umberto
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: A maximum likelihood methodology for the parameters of models with an intractable likelihood is introduced. We produce a likelihood-free version of the stochastic approximation expectation-maximization (SAEM) algorithm to maximize the likelihood function of model parameters. While SAEM is best suited for models having a tractable “complete likelihood” function, its application to moderately complex models is a difficult or even impossible task. We show how to construct a likelihood-free version of SAEM by using the “synthetic likelihood” paradigm. Our method is completely plug-and-play, requires almost no tuning and can be applied to both static and dynamic models.
H-Atmospheres of Icy Super-Earths Formed in situ in the Outer Solar System: An Application to a Possible Planet Nine
Creators: name: Levi, Amit
name: Kenyon, Scott J.
name: Podolak, Morris
name: Prialnik, Dina
Publisher: name: arXiv
Year: 2017
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We examine the possibility that icy super-Earth mass planets, formed over long time scales (0.1--1~Gyr) at large distances ($\sim$ 200--1000~AU) from their host stars, will develop massive H-rich atmospheres. Within the interior of these planets, high pressure converts CH$_4$ into ethane, butane, or diamond and releases H$_2$. Using simplified models which capture the basic physics of the internal structure, we show that the physical properties of the atmosphere depend on the outflux of H$_2$ from the mantle. When this outflux is $\lesssim 10^{10}$ [molec cm$^{-2}$ s$^{-1}$], the outgassed atmosphere has base pressure $\lesssim$ 1 bar. Larger outflows result in a substantial atmosphere where the base pressure may approach $10^3 - 10^4$ bar. For any pressure, the mean density of these planets, 2.4--3 [g cm$^{-3}$], is much larger than the mean density of Uranus and Neptune, 1.3--1.6 [g cm$^{-3}$]. Thus, observations can distinguish between a Planet Nine with a primordial H/He-rich atmosphere accreted from the protosolar nebula and one with an atmosphere outgassed from the core.
description: 32 pages, 11 figures, accepted to ApJ
How to write a science policy memo
Creators: name: Bankston, Adriana
Publisher: name: F1000 Research Limited
Year: 2022

description: This presentation was given at the Technical Professional Conference during the 2022 NSBE Annual Convention in Anaheim. The session took place on March 25, 2022 and featured published authors from the "Intersectional Science Policy" Special Topics Issue of the Journal of Science Policy & Governance (JSPG). Published issue: https://www.sciencepolicyjournal.org/jspgvol18iss04.html
Probing the infrared counterparts of diffuse far-ultraviolet sources in the Galaxy
Creators: name: Saikia, Gautam
name: Shalima, P.
name: Gogoi, Rupjyoti
name: Pathak, Amit
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Recent availability of high quality infrared (IR) data for diffuse regions in the Galaxy and external galaxies have added to our understanding of interstellar dust. A comparison of ultraviolet (UV) and IR observations may be used to estimate absorption, scattering and thermal emission from interstellar dust. In this paper, we report IR and UV observations for selective diffuse sources in the Galaxy. Using archival mid-infrared (MIR) and far-infrared (FIR) observations from Spitzer Space Telescope, we look for counterparts of diffuse far-ultraviolet (FUV) sources observed by the Voyager, Far Ultraviolet Spectroscopic Explorer (FUSE) and Galaxy Evolution Explorer (GALEX) telescopes in the Galaxy. IR emission features at 8micron are generally attributed to Polycyclic Aromatic Hydrocarbon (PAH) molecules, while emission at 24micron are attributed to Very Small Grains (VSGs). The data presented here is unique and our study tries to establish a relation between various dust populations. By studying the FUV-IR correlations separately at low and high latitude locations, we have identified the grain component responsible for the diffuse FUV emission.
description: 18 pages, 6 figures, 2 tables, Poster presented at the International Conference on Interstellar Dust, Molecules and Chemistry (IDMC-2014) held at Tezpur University, Assam, India
title: Niveaux d’imprégnation et déterminants de l’exposition humaine aux métaux en Nouvelle-Calédonie. Rapport scientifique final
Creators: name: Cordier, Sylvaine
name: Barguil, Yann
name: Dominique, Yannick
name: St-Jean, Audray
name: Mengant, Stéphane
name: Le Bot, Barbara
name: Ayotte, Pierre
Publisher: name: CNRT Nickel et son environnement
Year: 2018
Subjects: subject: FOS: Health sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Programme Métexpo [Métaux, vol. 3]. (Tome Nickel et Santé)
Synthesis of dual-stimuli responsive metal organic framework-coated iridium oxide nanocomposite functionalized with tumor targeting albumin-folate for synergistic photodynamic/photothermal cancer therapy
Creators: name: Deng, Xiangtian
name: Zhao, Renliang
name: Song, Qingcheng
name: Zhang, Yiran
name: Zhao, Haiyue
name: Hu, Hongzhi
name: Zhang, Zhen
name: Liu, Weijian
name: Lin, Wei
name: Wang, Guanglin
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Space Science
Medicine
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: The synergistic effects of photothermal therapy (PTT) and photodynamic therapy (PDT) has attracted considerable attention in the field of cancer therapy because of its excellent anti-tumor effect. This work provides a novel pH/NIR responsive therapeutic nanoplatform, IrO2@ZIF-8/BSA-FA (Ce6), producing a synergistic effect of PTT-PDT in the treatment of osteosarcoma. Iridium dioxide nanoparticles (IrO2 NPs) with exceptional catalase-like activity and PTT effects were synthesized by a hydrolysis method and decorated with zeolitic imidazolate framework-8 (ZIF-8) shell layer to promote the physical absorption of Chlorin e6 (Ce6), and further functionalized with bovine serum albumin-folate acid (BSA-FA) for targeting tumor cells. The IrO2@ZIF-8/BSA-FA nanocomposite indicated an outstanding photothermal heating conversion efficiency of 62.1% upon laser irradiation. In addition, the Ce6 loading endows nanoplatform with the capability to induce cell apoptosis under 660 nm near-infrared (NIR) laser irradiation through a reactive oxygen species (ROS)-mediated mechanism. It was further testified that IrO2@ZIF-8/BSA-FA can function as a catalase and convert the endogenous hydrogen peroxide (H2O2) into oxygen (O2) to improve the local oxygen pressure under the acidic tumor microenvironment (TME), which could subsequently amplified PDT-mediated ROS cell-killing performance via relieving hypoxia microenvironment of tumor. Both in vitro and in vivo experimental results indicated that the nanomaterials were good biocompatibility, and could remarkably achieve tumor-specific and enhanced combination therapy outcomes as compared with the corresponding PTT or PDT monotherapy. Taken together, this work holds great potential to design an intelligent multifunctional therapeutic nanoplatform for cancer therapy.
Additional file 9: Figure S6. of microRNAs associated with early neural crest development in Xenopus laevis
Creators: name: Ward, Nicole
name: Green, Darrell
name: Higgins, Janet
name: Dalmay, Tamas
name: Münsterberg, Andrea
name: Moxon, Simon
name: Wheeler, Grant
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: qPCR validation of small RNA sequencing. NC miRNAs identified by sRNA sequencing were validated using qPCR. The same RNA was used to make both the sRNA libraries and for qPCR. (A) Abundance plots of miRNAs; miR-219, miR-196a, miR-302 and nov-12a-1 following sRNA sequencing on blastula and ectoderm animal cap tissue and animal caps induced to form NC and neural tissue (B) qPCR validation of the miRNAs identified from the sRNA sequencing in the same order as A. One way ANOVA with Tukey post-test statistical analyses were performed on the results of each qPCR. For significance, we considered P > 0.01*; P > 0.001**; P > 0.0001*** and P > 0.0001****. (DOCX 186 kb)
Interaction and charge transfer between dielectric spheres: exact and approximate analytical solutions
Creators: name: Lindén, Fredrik
name: Cederquist, Henrik
name: Zettergren, Henning
Publisher: name: arXiv
Year: 2016
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: We present exact analytical solutions for charge transfer reactions between two arbitrarily charged hard dielectric spheres. These solutions, and the corresponding exact ones for sphere-sphere interaction energies, include sums that describe polarization effects to infinite orders in the inverse of the distance between the sphere centers. In addition, we show that these exact solutions may be approximated by much simpler analytical expressions that are useful for many practical applications. This is exemplified through calculations of Langevin type cross sections for forming a compound system of two colliding spheres and through calculations of electron transfer cross sections. We find that it is important to account for dielectric properties and finite sphere sizes in such calculations, which for example may be useful for describing the evolution, growth, and dynamics of nanometer sized dielectric objects such as molecular clusters or dust grains in different environments including astrophysical ones.
description: 23 pages, 8 figures
Additional file 1: of A systematic review on the use of healthcare services by undocumented migrants in Europe
Creators: name: Winters, Marjolein
name: Rechel, Bernd
name: Jong, Lea De
name: Pavlova, Milena
Publisher: name: figshare
Year: 2018
Subjects: subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Science Policy

description: Search strategy for Embase, Medline, Global Health and Cinahl Plus. (PDF 219 kb)
title: ADCO, Comptes du Petit-Cîteaux (1477-1491) (11 H 1179), f. 00300
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Archives Départementales De La Côte D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: comptes
subject: LaMOP

description: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179), f. 00300, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
title: Synthèse bibliographique des études de biosurveillance des populations vivant en zones minières ou à proximité d’industries émettrices de métaux
Creators: name: Cordier, Sylvaine
name: Ayotte, Pierre
name: Barguil, Yann
name: Dominique, Yannick
name: Ngueta, Gérard
Publisher: name: CNRT Nickel et son environnement
Year: 2016
Subjects: subject: FOS: Health sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Programme Métexpo. (Tome Nickel et Santé)
Monolith/Hydrogel composites as triamcinolone acetonide carriers for curing corneal neovascularization in mice by inhibiting the fibrinolytic system
Creators: name: Huang, Cixin
name: Qi, Xia
name: Chen, Huilin
name: Wei, Chao
name: Qi, Xiaolin
name: Wang, Hongwei
name: Gao, Hua
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Corneal neovascularization is a serious corneal pathological change caused by various factors. The drug delivery system is of great significance for the effective treatment of corneal neovascularization. Herein, we developed and characterized a monolith/hydrogel composite as the triamcinolone acetonide (TA) carrier for curing corneal neovascularization. The composite was prepared by photo-initiated free radical polymerization of multi-methacrylate substituted dodecamine organic molecular cage and post-modified by the sequential photo-initiated free radical polymerization of acrylated gelatin. The globular morphology and structural property of as-prepared composites were evaluated by scanning electron microscopy, Fourier-transform infrared spectroscopy and solid-state cross polarization magic angle spinning carbon-13 nuclear magnetic resonance. Then swelling ratio and the TA loading capacity were investigated then. Compared with gelatin hydrogel, the composites exhibited a decreased swelling ratio and an improved loading capacity. With good biocompatibility, the composite can sustainedly release TA for up to 28 days, and effectively inhibit corneal neovascularization with an alkali burn-induced corneal neovascularization model. Additionally, tandem mass tags-labeled quantitative proteomics were performed to identify differentially expressed proteins between vascularized and devascularized corneas. The Kyoto Encyclopedia of Genes and Genomes enrichment analysis revealed that the inhibition process could be primarily linked to the fibrinolytic system. These results demonstrated the potential of monolith/hydrogel composites as delivery systems in the therapy for biomedical diseases.
DETERMINANTES SOCIAIS DE SAÚDE E COMPLICAÇÕES DE PACIENTES COM PÉ DIABÉTICO: UMA REVISÃO DE ESCOPO
Creators: name: De Sousa, Caroline Ribeiro
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Medicine and Health Sciences

description: Diante do exposto, baseando-se nas pesquisas realizadas, o presente estudo visa analisar, por meio da literatura, quais determinantes sociais de saúde estão presentes na vida dos pacientes portadores de pé diabético, de modo que, identificando esses DSS e quais deles mais influenciam nas complicações do pé diabético, poderão fornecer informações cruciais para o estabelecimento de medidas eficazes, reduzindo as disparidades e promovendo um melhor bem estar entre os pacientes diabéticos.
Quantum-disordered state of magnetic and electric dipoles in a hydrogen-bonded Mott system
Creators: name: Shimozawa, M.
name: Hashimoto, K.
name: Ueda, A.
name: Suzuki, Y.
name: Sugii, K.
name: Yamada, S.
name: Imai, Y.
name: Kobayashi, R.
name: Itoh, K.
name: Iguchi, S.
name: Naka, M.
name: Ishihara, S.
name: Mori, H.
name: Sasaki, T.
name: Yamashita, M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Strongly enhanced quantum fluctuations often lead to a rich variety of quantum-disordered states. A representative case is liquid helium, in which zero-point vibrations of the helium atoms prevent its solidification at low temperatures. A similar behaviour is found for the internal degrees of freedom in electrons. Among the most prominent is a quantum spin liquid (QSL), in which localized spins are highly correlated but fluctuate even at absolute zero. Recently, a coupling of spins with other degrees of freedom has been proposed as an innovative approach to generate even more fascinating QSLs such as orbital--spin liquids. However, such ideas are limited to the internal degrees of freedom in electrons. Here, we demonstrate that a coupling of localized spins with the zero-point motion of hydrogen atoms (proton fluctuations) in a hydrogen-bonded organic Mott insulator provides a new class of QSLs. We find that a divergent dielectric behaviour towards a hydrogen-bond order is suppressed by the quantum proton fluctuations, resulting in a quantum paraelectric (QPE) state. Furthermore, our thermal-transport measurements reveal that a QSL state with gapless spin excitations rapidly emerges upon entering the QPE state. These findings indicate that the quantum proton fluctuations give rise to a novel QSL --- a quantum-disordered state of magnetic and electric dipoles --- through the coupling between the electron and proton degrees of freedom.
description: 10 pages, 8 figures
Additional file 8: Figure S5. of microRNAs associated with early neural crest development in Xenopus laevis
Creators: name: Ward, Nicole
name: Green, Darrell
name: Higgins, Janet
name: Dalmay, Tamas
name: MĂźnsterberg, Andrea
name: Moxon, Simon
name: Wheeler, Grant
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Hairpin structures of all novel miRNAs. (PDF 248Â kb)
Additional file 1 of In vitro antibacterial and cytotoxic effects of Euphorbia grandicornis Blanc chemical constituents
Creators: name: Kemboi, Douglas
name: Langat, Moses K.
name: Siwe-Noundou, Xavier
name: Krause, Rui W. M.
name: Isaacs, Michelle Louise
name: Tembu, Vuyelwa Jacqueline
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry

description: Additional file 1: Supplementary Materials. The following are available online alongside Appendix 1–12, Appendix LC-MS1-LCMS6, Table S1. 13C (δc) (100.6 MHZ) NMR data for compounds 1-11 in CDCl3, Table S2. 1H (δH, m, (J, Hz) NMR (400 MHZ) data for compounds 1–4 in CDCl3.
HC3N Observations of Nearby Galaxies
Creators: name: Jiang, Xue-Jian
name: Wang, Jun-Zhi
name: Gao, Yu
name: Gu, Qiu-Sheng
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Aims. We aim to systematically study the properties of the different transitions of the dense molecular gas tracer HC3N in galaxies. Methods. We have conducted single-dish observations of HC3N emission lines towards a sample of nearby gas-rich galaxies. HC3N(J=2-1) was observed in 20 galaxies with Effelsberg 100-m telescope. HC3N(J=24-23) was observed in nine galaxies with the 10-m Submillimeter Telescope (SMT). Results. HC3 N 2-1 is detected in three galaxies: IC 342, M 66 and NGC 660 (> 3 σ). HC3 N 24-23 is detected in three galaxies: IC 342, NGC 1068 and IC 694. This is the first measurements of HC3N 2-1 in a relatively large sample of external galaxies, although the detection rate is low. For the HC3 N 2-1 non-detections, upper limits (2 σ) are derived for each galaxy, and stacking the non-detections is attempted to recover the weak signal of HC3N. But the stacked spectrum does not show any significant signs of HC3N 2-1 emission. The results are also compared with other transitions of HC3N observed in galaxies. Conclusions. The low detection rate of both transitions suggests low abundance of HC3N in galaxies, which is consistent with other observational studies. The comparison between HC3N and HCN or HCO+shows a large diversity in the ratios between HC3N and HCN or HCO+. More observations are needed to interpret the behavior of HC3N in different types of galaxies.
description: A&A (Research Note) accepted
Additional file 7: Table S3. of microRNAs associated with early neural crest development in Xenopus laevis
Creators: name: Ward, Nicole
name: Green, Darrell
name: Higgins, Janet
name: Dalmay, Tamas
name: MĂźnsterberg, Andrea
name: Moxon, Simon
name: Wheeler, Grant
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: List of sequenced miRNAs that were not previously annotated in Xenopus laevis. (DOCX 48Â kb)
Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model
Creators: name: Liu, Yang
name: Zhu, Xiaoruo
name: Ji, Shiliang
name: Huang, Zhen
name: Zang, Yuhui
name: Ding, Ying
name: Zhang, Junfeng
name: Ding, Zhi
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Virology

description: Colchicine (Col) is used to prevent and treat acute gout flare; however, its therapeutic use is strictly limited owing to severe gastrointestinal side effects after oral administration. Therefore, we developed a dissolvable Col-loaded microneedle (MN) with hyaluronic acid to deliver Col via the transdermal route. We studied the preparation, mechanical properties, skin insertion, skin irritation, drug content, and transdermal release of the Col-loaded MN. The pharmacokinetics of Col after Col-loaded MN application were compared with those of Col solution gavage over 24 h. Knee joint edema evaluation and the hindfoot mechanical threshold test were conducted to determine the pharmacodynamic profile. The dissolvable Col-loaded MN possessed sufficient mechanical strength to penetrate the skin and release the loaded drug. No skin irritation was observed for 3 days after application. We found that 3.36-fold more Col contained in MNs was delivered through the skin compared with that in gel in vitro, and moderate relative bioavailability in vivo. The Col-loaded MN significantly relieved swollen knee joints and mechanical hypernociception in an acute gout model in rats. The dissolvable Col-loaded MN array reduced inflammation and pain via topical administration when acute gout occurred. Reducing the gastrointestinal side effects of Col-loaded MNs is expected to optimize the therapeutic effects of Col and improve patient compliance.
Cool WENO schemes
Creators: name: Cravero, Isabella
name: Puppo, Gabriella
name: Semplice, Matteo
name: Visconti, Giuseppe
Publisher: name: arXiv
Year: 2017
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: This work is dedicated to the development and comparison of WENO-type reconstructions for hyperbolic systems of balance laws. We are particularly interested in high order shock capturing non-oscillatory schemes with uniform accuracy within each cell and low spurious effects. We need therefore to develop a tool to measure the artifacts introduced by a numerical scheme. To this end, we study the deformation of a single Fourier mode and introduce the notion of distorsive errors, which measure the amplitude of the spurious modes created by a discrete derivative operator. Further we refine this notion with the idea of temperature, in which the amplitude of the spurious modes is weighted with its distance in frequency space from the exact mode. Following this approach linear schemes have zero temperature, but to prevent oscillations it is necessary to introduce nonlinearities in the scheme, thus increasing their temperature. However it is important to heat the linear scheme just enough to prevent spurious oscillations. With several tests we show that the newly introduced CWENOZ schemes are cooler than other existing WENO-type operators, while maintaining good non-oscillatory properties.
MOESM5 of A synergic effect between CYP2C19*2, CYP2C19*3 loss-of-function and CYP2C19*17 gain-of-function alleles is associated with Clopidogrel resistance among Moroccan Acute Coronary Syndromes patients
Creators: name: Idrissi, Hind Hassani
name: Wiam Hmimech
name: Khorb, Nada
name: Akoudad, Hafid
name: Habbal, Rachida
name: Sellama Nadifi
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Additional file 6. Details of the patientsâ recruitment, study design and statistical analysis.
Additional file 1 of Cyst stem cell lineage eIF5 non-autonomously prevents testicular germ cell tumor formation via eIF1A/eIF2γ-mediated pre-initiation complex
Creators: name: Li, Zhiran
name: Wu, Yunhao
name: Fu, Yangbo
name: Chen, Xia
name: Zhao, Xi
name: Wu, Xiaolong
name: Lu, Yajuan
name: He, Hui
name: Shen, Cong
name: Zheng, Bo
name: Yu, Jun
name: Sun, Fei
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Supplementary materials.
Additional file 1 of A multi-country survey on the impact of COVID-19 on dental practice and dentists’ feelings in Latin America
Creators: name: Moraes, Rafael R.
name: Cuevas-Suárez, Carlos E.
name: Escalante-Otárola, Wilfredo G.
name: Fernández, María R.
name: Dávila-Sánchez, Andrés
name: Grau-Grullon, Patricia
name: Fernández, Eduardo
name: López, Tania M.
name: Grazioli, Guillermo
name: Arana, Luis A.
name: Rondón, Luis F.
name: Torrez, Willy B.
name: Lima, Giana S.
name: Schuch, Helena S.
name: Correa, Marcos B.
name: Demarco, Flavio F.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
On self-affine sets
Creators: name: Käenmäki, Antti
Publisher: name: arXiv
Year: 2017
Subjects: subject: History and Overview (math.HO)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: We survey the dimension theory of self-affine sets for general mathematical audience. The article is in Finnish.
description: in Finnish
Design and applications of liposome-in-gel as carriers for cancer therapy
Creators: name: Mou, Yixuan
name: Zhang, Pu
name: Lai, Wing-Fu
name: Zhang, Dahong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Cancer has long been a hot research topic, and recent years have witnessed the incidence of cancer trending toward younger individuals with great socioeconomic burden. Even with surgery, therapeutic agents serve as the mainstay to combat cancer in the clinic. Intensive research on nanomaterials can overcome the shortcomings of conventional drug delivery approaches, such as the lack of selectivity for targeted regions, poor stability against degradation, and uncontrolled drug release behavior. Over the years, different types of drug carriers have been developed for cancer therapy. One of these is liposome-in-gel (LP–Gel), which has combined the merits of both liposomes and hydrogels, and has emerged as a versatile carrier for cancer therapy. LP–Gel hybrids have addressed the lack of stability of conventional liposomes against pH and ionic strength while displaying higher efficiency of delivery hydrophilic drugs as compared to conventional gels. They can be classified into three types according to their assembled structure, are characterized by their nontoxicity, biodegradability, and flexibility for clinical use, and can be mainly categorized based on their controlled release, transmucosal delivery, and transdermal delivery properties for anticancer therapy. This review covers the recent progress on the applications of LP–Gel hybrids for anticancer therapy.
MOESM4 of A synergic effect between CYP2C19*2, CYP2C19*3 loss-of-function and CYP2C19*17 gain-of-function alleles is associated with Clopidogrel resistance among Moroccan Acute Coronary Syndromes patients
Creators: name: Idrissi, Hind Hassani
name: Wiam Hmimech
name: Khorb, Nada
name: Akoudad, Hafid
name: Habbal, Rachida
name: Sellama Nadifi
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 60506 Virology
subject: Computational Biology

description: Additional file 5: Table S5. Genotypic and allelic distribution among the studies sample of patients.
Parametrices and exact paralinearisation of semi-linear boundary problems
Creators: name: Johnsen, Jon
Publisher: name: arXiv
Year: 2016
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35A17 (primary), 35B65 (secondary)

description: The subject is parametrices for semi-linear problems, based on parametrices for linear boundary problems and on non-linearities that decompose into solution-dependent linear operators acting on the solutions. Non-linearities of product type are shown to admit this via exact paralinearisation. The parametrices give regularity properties under weak conditions; improvements in subdomains result from pseudo-locality of type $1,1$-operators. The framework encompasses a broad class of boundary problems in Hölder and $L_p$-Sobolev spaces (and also Besov and Lizorkin--Triebel spaces). The Besov analyses of homogeneous distributions, tensor products and halfspace extensions have been revised. Examples include the von Karman equation.
description: 57 pages, 3 figures. Accepted version. Appeared online in Communications of partial differential equations on 4 December 2008; available at Taylor and Francis: http://www.tandfonline.com/doi/full/10.1080/03605300802289188
Additional file 1 of Matching-adjusted indirect treatment comparison of chimeric antigen receptor T-cell therapies for third-line or later treatment of relapsed or refractory large B-cell lymphoma: lisocabtagene maraleucel versus tisagenlecleucel
Creators: name: Cartron, Guillaume
name: Fox, Christopher P.
name: Liu, Fei Fei
name: Kostic, Ana
name: Hasskarl, Jens
name: Li, Daniel
name: Bonner, Ashley
name: Zhang, Yixie
name: Maloney, David G.
name: Kuruvilla, John
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. Clinical factors included for primary and sensitivity analyses comparing liso-cel with tisagenlecleucel. Table S2. Comparison of clinical factors before and after MAIC for primary and sensitivity analyses of PFS in TRANSCEND and JULIET. Table S3. Comparison of clinical factors before and after MAIC for primary and sensitivity analyses of CR in TRANSCEND and JULIET. Table S4. Comparison of clinical factors before and after MAIC for primary and sensitivity analyses of ORR in TRANSCEND and JULIET. Table S5. Comparison of clinical factors before and after MAIC for safety analysis in TRANSCEND and JULIET.
Middleware Technologies for Cloud of Things - a survey
Creators: name: Farahzadia, Amirhossein
name: Shams, Pooyan
name: Rezazadeh, Javad
name: Farahbakhsh, Reza
Publisher: name: arXiv
Year: 2017
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: The next wave of communication and applications rely on the new services provided by Internet of Things which is becoming an important aspect in human and machines future. The IoT services are a key solution for providing smart environments in homes, buildings and cities. In the era of a massive number of connected things and objects with a high grow rate, several challenges have been raised such as management, aggregation and storage for big produced data. In order to tackle some of these issues, cloud computing emerged to IoT as Cloud of Things (CoT) which provides virtually unlimited cloud services to enhance the large scale IoT platforms. There are several factors to be considered in design and implementation of a CoT platform. One of the most important and challenging problems is the heterogeneity of different objects. This problem can be addressed by deploying suitable "Middleware". Middleware sits between things and applications that make a reliable platform for communication among things with different interfaces, operating systems, and architectures. The main aim of this paper is to study the middleware technologies for CoT. Toward this end, we first present the main features and characteristics of middlewares. Next we study different architecture styles and service domains. Then we presents several middlewares that are suitable for CoT based platforms and lastly a list of current challenges and issues in design of CoT based middlewares is discussed.
description: http://www.sciencedirect.com/science/article/pii/S2352864817301268, Digital Communications and Networks, Elsevier (2017)