cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Les articulations de l'axe industriel littoral
title: Les articulations de l'axe industriel littoral
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Littoral

description: Cartographie
description: BESM-carto_1957-76-p487_76-02
description: 487
description: 76
description: Bulletin économique et social du Maroc
description: Source: Maison méditerranéenne des sciences de l'homme, Cité numérique de la Méditerranée (Cinumed), Bibliothèque nationale du Royaume du Maroc (BNRM)
description: Source: Bulletin économique et social du Maroc
description: Source: Bulletin économique et social du Maroc (BESM) > BESM (Cartographie)
description: Relation: https://cinumed.mmsh.univ-aix.fr/idurl/1/81869
description: Coverage: Maroc
description: Coverage: XXe siècle
description: Temporal: XXe siècle
description: Bibliographic citation: « Les articulations de l'axe industriel littoral », In Bulletin économique et social du Maroc (BESM), n° 76, 1957
description: Provenance: Maison méditerranéenne des sciences de l'homme, Cité numérique de la Méditerranée (Cinumed), Bibliothèque nationale du Royaume du Maroc (BNRM)
description: Provenance: https://cinumed.mmsh.univ-aix.fr/
Assessing the robustness and scalability of the accelerated pseudo-transient method towards exascale computing
Creators: name: Räss, Ludovic
name: Utkin, Ivan
name: Duretz, Thibault
name: Omlin, Samuel
name: Podladchikov, Yuri Y.
Publisher: name: ETH Zurich
Year: 2022

description: The development of highly efficient, robust and scalable numerical algorithms lags behind the rapid increase in massive parallelism of modern hardware. We address this challenge with the accelerated pseudo-transient iterative method and present here a physically motivated derivation. We analytically determine optimal iteration parameters for a variety of basic physical processes and confirm the validity of theoretical predictions with numerical experiments. We provide an efficient numerical implementation of pseudo-transient solvers on graphical processing units (GPUs) using the Julia language. We achieve a parallel efficiency over 96 % on 2197 GPUs in distributed memory parallelisation weak scaling benchmarks. 2197 GPUs allow for unprecedented terascale solutions of 3D variable viscosity Stokes flow on 49953 grid cells involving over 1.2 trillion degrees of freedom. We verify the robustness of the method by handling contrasts up to 9 orders of magnitude in material parameters such as viscosity, and arbitrary distribution of viscous inclusions for different flow configurations. Moreover, we show that this method is well suited to tackle strongly nonlinear problems such as shear-banding in a visco-elasto-plastic medium. A GPU-based implementation can outperform CPU-based direct-iterative solvers in terms of wall-time even at relatively low resolution. We additionally motivate the accessibility of the method by its conciseness, flexibility, physically motivated derivation and ease of implementation. This solution strategy has thus a great potential for future high-performance computing applications, and for paving the road to exascale in the geosciences and beyond.
description: Geoscientific Model Development Discussions
description: ISSN:1991-962X
description: ISSN:1991-9611
A missense variant effect prediction and annotation resource for SARS-CoV-2
Creators: name: Dunham, Alistair
name: Jang, Gwendolyn M.
name: Muralidharan, Monita
name: Swaney, Danielle
name: Beltrao, Pedro
Publisher: name: ETH Zurich
Year: 2021

description: The COVID19 pandemic is a global crisis severely impacting many people across the world. An important part of the response is monitoring viral variants and determining the impact they have on viral properties, such as infectivity, disease severity and interactions with drugs and vaccines. In this work we generate and make available computational variant effect predictions for all possible single amino-acid substitutions to SARS-CoV-2 in order to complement and facilitate experiments and expert analysis. The resulting dataset contains predictions from evolutionary conservation and protein and complex structural models, combined with viral phosphosites, experimental results and variant frequencies. We demonstrate predictions’ effectiveness by comparing them with expectations from variant frequency and prior experiments. We then identify higher frequency variants with significant predicted effects as well as finding variants measured to impact antibody binding that are least likely to impact other viral functions. A web portal is available at sars.mutfunc.com, where the dataset can be searched and downloaded.
description: bioRxiv
Book Review: Danielle Celermajer ‘Summertime: Reflections on a Vanishing Future’
Creators: name: Eriksen, Christine
Publisher: name: ETH Zurich
Year: 2022
Subjects: climate change
climate crisis

description: CSS' Christine Eriksen reviews Danielle Celermajer's book "Summertime: Reflections on a vanishing future", a thoughtful exploration of the climate crisis, for the Australian Journal of Emergency Management.
description: CSS Forscherin Christine Eriksen rezensiert Danielle Celermajers Buch "Summertime: Reflections on a vanishing future" für das Australian Journal of Emergency Management und bezeichnet es als eine nachdenkliche Auseinandersetzung mit der Klimakrise.
description: Australian Journal of Emergency Management, 37 (1)
Chance-constrained OPF: A Distributed Method with Confidentiality Preservation
Creators: name: Jia, Mengshuo
name: Hug, Gabriela
name: Su, Yifan
name: Shen, Chen
Publisher: name: ETH Zurich
Year: 2022
Subjects: wind power
Chance constraints
OPF
Distributed computing
Confidentiality preservation

description: Given the increased percentage of wind power in power systems, chance-constrained optimal power flow (CC-OPF) calculation, as a means to take wind power uncertainty into account with a guaranteed security level, is being promoted. Compared to the local CC-OPF within a regional grid, the global CC-OPF of a multi-regional interconnected grid is able to coordinate across different regions and therefore improve the economic efficiency when integrating high percentage of wind power generation. In this global problem, however, multiple regional independent system operators (ISOs) participate in the decision-making process, raising the need for distributed but coordinated approaches. Most notably, due to regulation restrictions, commercial interest, and data security, regional ISOs may refuse to share confidential information with others, including generation cost, load data, system topologies, and line parameters. But this information is needed to build and solve the global CC-OPF spanning multiple areas. To tackle these issues, this paper proposes a distributed CC-OPF method with confidentiality preservation, which enables regional ISOs to determine the optimal dispatchable generations within their regions without disclosing confidential data. This method does not require parameter tunings and will not suffer from convergence challenges. Results from IEEE test cases show that this method is highly accurate.
Control-aware Probabilistic Load Flow for Transmission Systems: An Analytical Method
Creators: name: Jia, Mengshuo
name: Cao, Qianni
name: Shen, Chen
name: Hug, Gabriela
Publisher: name: ETH Zurich
Year: 2022
Subjects: Probabilistic load flow
Control
Frequency regulation
Analytical methods
transmission systems

description: Probabilistic load flow (PLF) calculation, as a fundamental tool to analyze transmission system behavior, has been studied for decades. Despite a variety of available methods, existing PLF approaches rarely take system control into account. However, system control, as an automatic buffer between the fluctuations in random variables and the variations in system states, has a significant impact on the final PLF result. To consider control actions' influence, this paper proposes the first analytical PLF method for the transmission grid that takes into account primary and secondary frequency controls. This method is based on a high-precision linear power flow model, whose precision is even further improved in this paper by an original correction approach. This paper also proves that if the joint probability distribution (JPD) of random variables is expressed by a Gaussian mixture model (GMM), then the JPD of system states (e.g., nodal voltages) is an infinite GMM. By leveraging this proposition, the proposed method can generate the joint PLF of the whole system, is applicable to random variables obeying any distributions, and is capable of capturing their correlation. The high accuracy and satisfactory efficiency of this method are verified on test cases scaling from 14 to 1354 buses.
Stannate-based Ceramic Oxide as Anode Materials for Oxide-ion Conducting Low-Temperature Solid Oxide Fuel Cells
Creators: name: Jabbar, Mohammed Hussain Abdul
Publisher: name: figshare
Year: 2016
Subjects: subject: 91305 Energy Generation, Conversion and Storage Engineering
subject: FOS: Mechanical engineering

description: Lanthanum-doped barium stannate, Ba0.98La0.02SnO3 (LBS) ceramic oxide was developed as an alternative redox stable anode material for oxide-ion conducting, low-temperature solid oxide fuel cells (350-650°C). LBS with ZnO as a sintering aid exhibited a high electronic conductivity of 216 S/cm at 650°C under reducing gas conditions. A flexural strength of ~66 MPa at 550°C was obtained for ZnO-doped LBS; further investigation revealed that it can withstand 10 reduction-oxidation and thermal cycles. The performance of ZnO-doped LBS as an anode was determined with a GDC based electrolyte-supported SOFC. The catalytic activity for hydrogen oxidation and oxide conductivity was introduced by infiltration of Ni-GDC precursor. The maximum power densities of 0.28 W/cm2 (at 0.6 A/cm2) and 0.17 W/cm2 (at 0.36 A/cm2) was achieved at 650 and 600°C, respectively, in humidified hydrogen as fuel for 2 wt. % ZnO-doped LBS.
Pan-Cancer landscape of protein activities identifies drivers of signalling dysregulation and patient survival
Creators: name: Sousa, Abel
name: Dugourd, Aurelien
name: Memon, Danish
name: Petursson, Borgthor
name: Petsalaki, Evangelia
name: Saez-Rodriguez, Julio
name: Beltrao, Pedro
Publisher: name: ETH Zurich
Year: 2021

description: Genetic alterations in cancer cells trigger oncogenic transformation, a process largely mediated by the dysregulation of kinase and transcription factor (TF) activities. While the mutational profiles of thousands of tumours has been extensively characterized, the measurements of protein activities has been technically limited until recently. We compiled public data of matched genomics and (phospho)proteomics measurements for 1,110 tumours and 77 cell lines that we used to estimate activity changes in 218 kinases and 292 TFs. Kinase activities are, on average, not strongly determined by protein abundance but rather by their phosphorylation state while the reverse is more common for TFs. Co-regulation of kinase and TF activities reflects previously known regulatory relationships and allows us to dissect genetic drivers of signalling changes in cancer. Loss-of-function mutation is not often associated with dysregulation of downstream targets, suggesting frequent compensatory mechanisms. Finally, we identified the activities most differentially regulated in cancer subtypes and showed how these can be linked to differences in patient survival. Our results provide broad insights into dysregulation of protein activities in cancer and their contribution to disease severity.
description: bioRxiv
Deep Learning Model with GA based Feature Selection and Context Integration
Creators: name: Mandal, Ranju
name: Azam, Basim
name: Verma, Brijesh
name: Zhang, Mengjie
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Deep learning models have been very successful in computer vision and image processing applications. Since its inception, Many top-performing methods for image segmentation are based on deep CNN models. However, deep CNN models fail to integrate global and local context alongside visual features despite having complex multi-layer architectures. We propose a novel three-layered deep learning model that assiminlate or learns independently global and local contextual information alongside visual features. The novelty of the proposed model is that One-vs-All binary class-based learners are introduced to learn Genetic Algorithm (GA) optimized features in the visual layer, followed by the contextual layer that learns global and local contexts of an image, and finally the third layer integrates all the information optimally to obtain the final class label. Stanford Background and CamVid benchmark image parsing datasets were used for our model evaluation, and our model shows promising results. The empirical analysis reveals that optimized visual features with global and local contextual information play a significant role to improve accuracy and produce stable predictions comparable to state-of-the-art deep CNN models.
Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer
Creators: name: Memon, Danish
name: Rizvi, Hira
name: Fromm, George
name: Lihm, Jayon
name: Schoenfeld, Adam J.
name: Sauter, Jennifer L.
name: Luo, Jia
name: Chow, Andrew
name: Bhanot, Umesh K.
name: McCarthy, Caroline
name: Ye, Darwin
name: Vanderbilt, Chad M.
name: Liu, Cailian
name: Abu-Akeel, Mohsen
name: Plodkowski, Andrew J.
name: McGranahan, Nicholas
name: Luksza, Marta
name: Greenbaum, Benjamin D.
name: Merghoub, Taha
name: Minn, Andy J.
name: Beltrao, Pedro
name: Schreiber, Taylor H.
name: Miller, Martin L.
name: Hellmann, Matthew D.
Publisher: name: ETH Zurich
Year: 2021

description: Although cancer immunotherapy with PD-(L)1 blockade is now routine treatment for patients with lung cancer, remarkably little is known about acquired resistance. We examined 1,201 patients with NSCLC treated with PD-(L)1 blockade to clinically characterize acquired resistance, finding it to be common (occurring in more than 60% of initial responders), with persistent but diminishing risk over time, and with distinct metastatic and survival patterns compared to primary resistance. To examine the molecular phenotype and potential mechanisms of acquired resistance, we performed whole transcriptome and exome tumor profiling in a subset of NSCLC patients (n=29) with acquired resistance. Systematic immunogenomic analysis revealed that tumors with acquired resistance generally had enriched signals of inflammation (including IFNγ signaling and inferred CD8+ T cells) and could be separated into IFNγ upregulated and stable subsets. IFNγ upregulated tumors had putative routes of resistance with signatures of dysfunctional interferon signaling and mutations in antigen presentation genes. Transcriptomic profiling of cancer cells from a murine model of acquired resistance to PD-(L)1 blockade also showed evidence of dysfunctional interferon signaling and acquired insensitivity to in vitro interferon gamma treatment. In summary, we characterized clinical and molecular features of acquired resistance to PD-(L)1 blockade in NSCLC and found evidence of ongoing but dysfunctional IFN response. The persistently inflamed, rather than excluded or deserted, tumor microenvironment of acquired resistance informs therapeutic strategies to effectively reprogram and reverse acquired resistance.
description: bioRxiv
Towards a structurally resolved human protein interaction network
Creators: name: Burke, David F.
name: Bryant, Patrick
name: Barrio-Hernandez, Inigo
name: Memon, Danish
name: Pozzati, Gabriele
name: Shenoy, Aditi
name: Zhu, Wensi
name: Dunham, Alistair S.
name: Albanese, Pascal
name: Keller, Andrew
name: Scheltema, Richard A.
name: Bruce, James E.
name: Leitner, Alexander
name: Kundrotas, Petras
name: Beltrao, Pedro
name: Elofsson, Arne
Publisher: name: ETH Zurich
Year: 2021

description: All cellular functions are governed by complex molecular machines that assemble through protein-protein interactions. Their atomic details are critical to the study of their molecular mechanisms but fewer than 5% of hundreds of thousands of human interactions have been structurally characterized. Here, we test the potential and limitations of recent progress in deep-learning methods using AlphaFold2 to predict structures for 65,484 human interactions. We show that higher confidence models are enriched in interactions supported by affinity or structure based methods and can be orthogonally confirmed by spatial constraints defined by cross-link data. We identify 3,137 high confidence models, of which 1,371 have no homology to a known structure, from which we identify interface residues harbouring disease mutations, suggesting potential mechanisms for pathogenic variants. We find groups of interface phosphorylation sites that show patterns of co-regulation across conditions, suggestive of coordinated tuning of multiple interactions as signalling responses. Finally, we provide examples of how the predicted binary complexes can be used to build larger assemblies. Accurate prediction of protein complexes promises to greatly expand our understanding of the atomic details of human cell biology in health and disease.
description: bioRxiv
Person und Wissen: Bilanz und Perspektiven
Creators: name: Gubler, Kaspar
name: Hesse, Christian
name: Schwinges, Rainer C.
Publisher: name: ETH Zurich
Year: 2022
Subjects: Geisteswissenschaften
Sozialwissenschaften

description: Repertorium Academicum Germanicum (RAG) - Forschungen, 4
description: ISBN:978-3-7281-4114-9
Theoretical study on keto–enol tautomerisation of glutarimide for exploration of the isomerisation reaction pathway of glutamic acid in proteins using density functional theory
Creators: name: Fukuyoshi, Shuichi
name: Nakayoshi, Tomoki
name: Ohgi Takahashi
name: Oda, Akifumi
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: In order to elucidate the reason why glutamic acid residues have lesser racemisation reactivity than asparaginic acid, we investigated the racemisation energy barrier of piperidinedione, which is the presumed intermediate of the isomerisation reaction of L-Glu to D-Glu, by density functional theory calculations. In two-water-molecule-assisted racemisation, the activation barrier for keto–enol isomerisation was 28.1 kcal/mol. The result showed that the activation barrier for the racemisation of glutamic acid residues was not different from that for the racemisation of aspartic acid residues. Thus, glutamic acid residues can possibly cause the racemisation reaction if the cyclic intermediate stably exists.
A structural biology community assessment of AlphaFold 2 applications
Creators: name: Akdel, Mehmet
name: Pires, Douglas EV.
name: Porta Prado, Eduard
name: Jänes, Jürgen
name: Zalevsky, Arthur O.
name: Mészáros, Bálint
name: Bryant, Patrick
name: Good, Lydia L.
name: Laskowski, Roman A.
name: Pozzati, Gabriele
name: Shenoy, Aditi
name: Zhu, Wensi
name: Kundrotas, Petras
name: Ruiz Serra, Victoria
name: Rodrigues, Carlos H. M.
name: Dunham, Alistair S.
name: Burke, David
name: Borkakoti, Neera
name: Velankar, Sameer
name: Frost, Adam
name: Lindorff-Larsen, Kresten
name: Valencia, Alfonso
name: Ovchinnikov, Sergey
name: Durairaj, Janani
name: Ascher, David B.
name: Thornton, Janet M.
name: Davey, Norman E.
name: Stein, Amelie
name: Elofsson, Arne
name: Croll, Tristan I.
name: Beltrao, Pedro
Publisher: name: ETH Zurich
Year: 2021

description: bioRxiv
Effect of neuronal innervation on the properties of hPSC-derived cardiomyocytes
Creators: name: Mohammadi, Neda
Publisher: name: Imperial College London
Year: 2023

description: The sympathetic division of the autonomic nervous system is known as the sympathetic nervous system (SNS) and is especially important for the involuntary control of heart rhythm. Specifically, ionotropic (force), chronotropic (rate) and dromotropic (conduction velocity) response in the heart is affected through autonomic innervation. The heart-brain axis has been studied extensively in vivo. Given this knowledge, conventionally immature human pluripotent stem cell-derived cardiomyocytes (hPSC-CM) were used in coculture with sympathetic neurons (SN) isolated from neonatal rat pups, to model the neuro-cardiac junction (NCJ), and better understand this cell-cell interaction in vitro. IMR90 stem cells were differentiated in-house into hPSC-CM. The structural relationship was first investigated through confocal imaging and microscopy (SICM). The functional relationship was investigated using FRET microscopy, which measures changes in the important secondary messenger molecule (cAMP) of the CM. Contraction and calcium handling were investigated in cells paced at 1 Hz in a novel attempt, using the CytoCypher. Immunostaining showed that SN express a prominent marker of neuroexocytosis. They also fire action potentials in response to nicotine, indicating functional intercellular communication in coculture. Neurite sprouting increased over time but with no significant difference in the morphology of the NCJ. HPSC-CM in coculture became elongated, as shown by reduced cell circularity index. Functional investigation into this relationship found that cAMP levels in response to nicotine are significantly higher in cocultured CM compared to monocultures. Moreover, contraction and calcium transient amplitude was significantly larger in coculture and at baseline, prior to stimulation of SN with nicotine. Interestingly, the action potential dynamics of the IMR90 hPSC-CM was matured in coculture, with larger amplitude and greater sodium channel activity. This thesis highlights a critical role for the structural and functional development of hPSC-CM towards a more physiological condition when cocultured with SN in vitro.
Публікації щодо кваліфікацій та компетентностей (анотований покажчик праць за 2020-2024 роки)
Creators: name: Semigina, Tetyana
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 390299
subject: Education policy, sociology and philosophy not elsewhere classified

description: У брошурі проанатовано наукові праці, опубліковані у 2020-2024 роках, з тематики системи кваліфікацій та формування компетентностей.Видання може бути використано як довідково-пошуковий матеріал тими, хто цікавиться розвитком системи професійних кваліфікацій.
Tailored recommendations for older adults with comorbid dementia in chronic disease guidelines: protocol for a scoping review
Creators: name: Ouellet, Gregory M.
name: Mecca, Marcia C.
name: Funaro, Melissa C.
name: Hu, Tiffany Y.
name: Fried, Terri R.
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Medicine and Health Sciences

description: Protocol for a scoping review of tailored recommendations for management of chronic conditions in older persons, persons with limited life expectancy, and dementia.
Analysis of the type II robotic mixed-model assembly line balancing problem
Creators: name: Çil, Zeynel Abidin
name: Mete, Süleyman
name: Kürşad Ağpak
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: In recent years, there has been an increasing trend towards using robots in production systems. Robots are used in different areas such as packaging, transportation, loading/unloading and especially assembly lines. One important step in taking advantage of robots on the assembly line is considering them while balancing the line. On the other hand, market conditions have increased the importance of mixed-model assembly lines. Therefore, in this article, the robotic mixed-model assembly line balancing problem is studied. The aim of this study is to develop a new efficient heuristic algorithm based on beam search in order to minimize the sum of cycle times over all models. In addition, mathematical models of the problem are presented for comparison. The proposed heuristic is tested on benchmark problems and compared with the optimal solutions. The results show that the algorithm is very competitive and is a promising tool for further research.
Geology and geochemistry of Late Quaternary volcanism in northern Harrat Rahat, Kingdom of Saudi Arabia: implications for eruption dynamics, regional stratigraphy and magma evolution
Creators: name: H. Murcia
name: J. M. Lindsay
name: K. Nemeth
name: I. E. M. Smith
name: S. J. Cronin
name: M. R. H. Moufti
name: N. N. El-Masry
name: S. Niedermann
Publisher: name: Geological Society of London
Year: 2016
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Mineral chemistry results
Sapinet: A sparse event-based spatiotemporal oscillator for learning in the wild
Creators: name: Borthakur, Ayon
Publisher: name: arXiv
Year: 2022
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: We introduce Sapinet -- a spike timing (event)-based multilayer neural network for \textit{learning in the wild} -- that is: one-shot online learning of multiple inputs without catastrophic forgetting, and without the need for data-specific hyperparameter retuning. Key features of Sapinet include data regularization, model scaling, data classification, and denoising. The model also supports stimulus similarity mapping. We propose a systematic method to tune the network for performance. We studied the model performance on different levels of odor similarity, gaussian and impulse noise. Sapinet achieved high classification accuracies on standard machine olfaction datasets without the requirement of fine tuning for a specific dataset.
description: PhD thesis
Annual variability of the long-lived anthropogenic radionuclides 129I and 236U in the Fram Strait and their use as water mass composition tracers
Creators: name: Wefing, Anne-Marie
name: Casacuberta, Núria
name: Christl, Marcus
name: Karcher, Michael
name: Dodd, Paul A.
Publisher: name: ETH Zurich
Year: 2021

description: Anthropogenic chemical tracers are powerful tools to study pathways, water mass provenance and mixing processes in the ocean. Releases of the long-lived anthropogenic radionuclides 129I and 236U from European nuclear reprocessing plants label Atlantic Water entering the Arctic Ocean with a distinct signal that can be used to track pathways and timescales of Atlantic Water circulation in the Arctic Ocean and Fram Strait. Apart from their application as transient tracers, the difference in anthropogenic radionuclide concentrations between Atlantic- and Pacific-origin water provides an instrument to distinguish the interface between both water masses. In contrast to classically used water mass tracers such as nitrate-phosphate (N:P) ratios, the two radionuclides are considered to behave conservatively in seawater and are not affected by biogeochemical processes occurring in particular in the broad shelf regions of the Arctic Ocean.

Here we present a time-series of 129I and 236U data across the Fram Strait, collected in 2016 (as part of the GEOTRACES program) and in 2018 and 2019 (by the Norwegian Polar Institute). While the overall spatial distribution of both radionuclides was similar among the three sampling years, significant differences were observed in the upper water column of the EGC, especially between 2016 and 2018. This study is the first attempt to investigate the potential of 129I and 236U as water mass composition tracers in the East Greenland Current (EGC). We discuss how the 129I - 236U tracer pair can be applied to estimate fractions of Atlantic and Pacific Water, especially considering their time-dependent input into the Arctic Ocean.
description: EGUsphere
Geology and geochemistry of Late Quaternary volcanism in northern Harrat Rahat, Kingdom of Saudi Arabia: implications for eruption dynamics, regional stratigraphy and magma evolution
Creators: name: H. Murcia
name: J. M. Lindsay
name: K. Nemeth
name: I. E. M. Smith
name: S. J. Cronin
name: M. R. H. Moufti
name: N. N. El-Masry
name: S. Niedermann
Publisher: name: Geological Society of London
Year: 2016
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Fractional crystallization modeling data
Geology and geochemistry of Late Quaternary volcanism in northern Harrat Rahat, Kingdom of Saudi Arabia: implications for eruption dynamics, regional stratigraphy and magma evolution
Creators: name: H. Murcia
name: J. M. Lindsay
name: K. Nemeth
name: I. E. M. Smith
name: S. J. Cronin
name: M. R. H. Moufti
name: N. N. El-Masry
name: S. Niedermann
Publisher: name: Geological Society of London
Year: 2016
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Whole-rock chemistry results
The growing exposure of Pacific coral reefs to compound extremes caused by marine heatwaves coalescing with low saturation state extremes
Creators: name: Gregor, Luke
name: Gruber, Nicolas
Publisher: name: ETH Zurich
Year: 2021

description: The ocean has played a key role in mitigating the impact of climate change by taking up excess anthropogenic heat and CO2 leading to warming and increased ocean acidity, which goes in hand with a reduction of the saturation state of seawater with regard to the mineral carbonate aragonite, i.e., ΩAR. While the threats posed by these long-term changes to marine organisms and ecosystems are well recognized, only more recently has the community realized that these threats might be much more imminent owing to extreme events. This is the result of these extremes exposing vulnerable ecosystems already today to conditions that lie in the far future when considering only the changes in the mean conditions. Of particular concern are so-called compound events, i.e., conditions when both temperatures are extremely hot and the saturation states extremely low, as this compounding might be particularly threatening for marine ecosystems, especially for warm water coral reefs.

Here we use satellite records of sea surface temperature (SST) and satellite ΩAR to map globally the occurrence of marine heat waves (MHW) and low saturation state extreme events and their compounding for the period 1985 and 2018. We use SSTs from the OSTIA product, while we take ΩAR from the newly developed OceanSODA-ETHZ (monthly 1°x1°) observation-based product that extrapolates ship observations with satellite data. Our study focuses on the Pacific Ocean between 25°S and 25°N, a region with more than 1000 identified coral reefs. We define extremes using the approach of Hobday et al. (2018) with a fixed baseline determined from the entire record (1985-2018) and where extremes are below/above the 10th/90th percentiles for Ω/SST respectively.

The majority of the compound extreme events (too hot and too low saturation state) occur in the western tropical Pacific, with 757 of the 1206 reefs in the Pacific experiencing at least three months of compound extreme events over the entire period. The average duration of these compound extremes was 3.6 months, and the average area was 247 600 km2 (roughly the size of the United Kingdom). The compound events had an average intensity of –0.13 for ΩAR and 0.71°C, where the intensity is the anomaly from the climatology. The largest and longest lasting extreme event started in 2016 and lasted nearly three years, coinciding with the El Niño event over the same period, covering an area equivalent to Australia. These findings suggest that more than 60% of coral reefs in the Pacific Ocean are located in regions where heating events may have been compounded by decreased potential for calcification. Given the continuing increase in atmospheric CO2, the severity of this type of compound events is bound to increase in the future.
description: EGUsphere
Acoustic Metal Particle Focusing in a Round Glass Capillary
Creators: name: Gerlt, Michael
name: Paeckel, Adrià
name: Pavlic, Alen
name: Rohner, Patrik
name: Poulikakos, Dimosthenis
name: Dual, Jürg
Publisher: name: ETH Zurich
Year: 2021

description: Two-dimensional metal particle focusing is an essential task for various fabrication processes. While acoustofluidic devices can manipulate particles in two dimensions, the production of these devices often demands a cleanroom environment. Therefore, acoustically excited glass capillaries present a cheap alternative to labour-intensive cleanroom production. Here, we present 2D metal micro-particle focusing in a round glass capillary using bulk acoustic waves. Excitation of the piezoelectric transducer at specific frequencies leads to mode shapes in the round capillary, concentrating particles towards the capillary centre. We experimentally investigate the particle linewidth for different particle materials and concentrations. We demonstrate the focus of copper particles with 1 μm in diameter down to a line of width 60.8 ± 7.0 μm and height 45.2 ± 9.3 μm, corresponding to a local concentration of 4.5 % v/v, which is 90 times higher than the concentration of the initial solution. Through numerical analysis, we could obtain further insights into the particle manipulation mechanism inside the capillary and predict the particle trajectories. We found that a transition of the acoustic streaming pattern enables us to manipulate particles close to the critical particle radius. Finally, we used our method to eject copper particles through a tapered round capillary with an opening of 25 μm in diameter, which would not be possible without particle focusing. Our novel setup can be utilized for various applications, that otherwise might suffer from abrasion, clogging and limited resolution.
description: arXiv
Open-source personal pipetting robots with live-cell incubation and microscopy compatibility
Creators: name: Dettinger, Philip
name: Kull, Tobias
name: Arekatla, Geethika
name: Ahmed, Nouraiz
name: Zhang, Yang
name: Schneiter, Florin
name: Wehling, Arne
name: Schirmacher, Daniel
name: Kawamura, Shunsuke
name: Loeffler, Dirk
name: Schroeder, Timm
Publisher: name: ETH Zurich
Year: 2021

description: Liquid handling robots have the potential to automate many procedures in life sciences. However, they are not in widespread use in academic settings, where funding, space and maintenance specialists are usually limiting. In addition, current robots require lengthy programming by specialists and are incompatible with most academic laboratories with constantly changing small-scale projects. Here, we present the Pipetting Helper Imaging Lid (PHIL), an inexpensive, small, open-source personal liquid handling robot. It is designed for inexperienced users, with self-production from cheap commercial and 3D-printable components and custom control software. PHIL successfully automated pipetting for e.g. tissue immunostainings and stimulations of live stem and progenitor cells during time-lapse microscopy. PHIL is cheap enough for any laboratory member to have their own personal pipetting robot(s), and enables users without programming skills to easily automate a large range of experiments.
description: bioRxiv
title: Anthocercis ilicifolia subsp. caldariola
title: Version 1
titleType: Subtitle
Creators: name: L.Haegi, R.W.Purdie
Publisher: name: Flora of Australia
Year: 2020
Subjects: Anthocercis ilicifolia subsp. caldariola

description: Taxonomic treatment for Anthocercis ilicifolia subsp. caldariola
Fock space coupled cluster study of the 11Πg state of the Li2 molecule
Creators: name: Musiał, Monika
name: Łukasz Lupa
name: Stanisław A. Kucharski
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology

description: Recently reported (M. Musiał, J. Chem. Phys., 136, 134111 (2012)) multireference coupled cluster method formulated in the (2,0) sector of the Fock space proved to be an efficient scheme in the treatment of potential energy curves (PECs) for alkali metal diatomics Me2. The (2,0) sector provides description of states obtained by an attachment of two electrons to the reference which for the Me2 is a doubly ionised Me+ 2 2 system. The latter has a very concrete advantage in the calculations of the PECs since it dissociates into closed shell fragments (Me+ 2 2 → Me++Me+); hence, the restricted Hartree–Fock reference can be used in the whole range of interatomic distances. In this work, an accurate PEC and vibrational energy levels are obtained for the state of the lithium dimer. The average deviation of the vibrational term values from experiment is 0.79 wavenumber and is significantly lower than that provided by other theoretical works.
The non-ideal finite Larmor radius effect in the solar atmosphere
Creators: name: Pandey, B. P.
name: Wardle, Mark
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The dynamics of the partially ionized solar atmosphere is controlled by the frequent collision and charge exchange between the predominant neutral Hydrogen atoms and charged ions. At signal frequencies below or of the order of either of the collision or charge exchange frequencies the magnetic stress is {\it felt} by both the charged and neutral particles simultaneously. The resulting neutral-mass loading of the ions leads to the rescaling of the effective ion-cyclotron frequency-it becomes the Hall frequency, and the resultant effective Larmor radius becomes of the order of few kms. Thus the finite Larmor radius (FLR) effect which manifests as the ion and neutral pressure stress tensors operates over macroscopic scales. Whereas parallel and perpendicular (with respect to the magnetic field) viscous momentum transport competes with the Ohm and Hall diffusion of the magnetic field in the photosphere-chromosphre, the gyroviscous effect becomes important only in the transition region between the chromosphere and corona, where it competes with the ambipolar diffusion. The wave propagation in the gyroviscous effect dominated medium depends on the plasma $β$ (a ratio of the thermal and magnetic energies). The abundance of free energy makes gyro waves unstable with the onset condition exactly opposite of the Hall instability. However, the maximum growth rate is identical to the Hall instability. For a flow gradient $\sim 0.1 \,\mbox{s}^{-1}$ the instability growth time is one minute. Thus, the transition region may become subject to this fast growing, gyroviscous instability.
description: 17 pages, 12 figures, MNRAS (in press)
Age and Masculinities During the Neo-Assyrian Period
Creators: name: Bennett, Ellie
Publisher: name: Humanities Commons
Year: 2024
Subjects: subject: Assyrians
subject: History, Ancient
subject: Mesopotamia
subject: Masculinity
subject: Aging
subject: Sex role

description: The age of an individual changes how other elements of identity, like masculinity, are expressed. For example, the modern expectations of "old men" and "young men" are very different. Here, I explore the differences between “young” and “old” men as expressed in the Neo-Assyrian textual corpus on the Open Richly Annotated Cuneiform Corpus (Oracc). This corpus offers a unique opportunity to incorporate recently developed word co-occurrence methods alongside a traditional close reading approach in order to explore the differences between old and young men in Neo-Assyrian texts. 􀀬 demonstrate that young men were conceptually different from old men, and both were key to the construction of Neo-Assyrian hegemonic masculinities.
Anti-polar state in BiFeO3/NdFeO3 superlattices
Creators: name: Khaled, Mohamed Ali
name: Arnold, Donna C
name: Dkhil, Brahim
name: Jouiad, Mustapha
name: Hoummada, Khalid
name: Marssi, Mimoun El
name: Bouyanfif, Houssny
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Antiferroelectrics are promising materials for high energy density capacitors and the search for environmentally-friendly and efficient systems is actively pursued. An elegant strategy to create and design new (anti)ferroic system relies on the use of nanoscale superlattices. We report here the use of such strategy and the fabrication of nanoscale BiFeO3/NdFeO3 superlattices and in depth characterization using high resolution X-ray diffraction and Transmission Electron Microscopy. The structural analysis at atomic scale demonstrates that such superlattices host anti-polar ordering most likely described by an antiferroelectric-like Pbnm symmetry. Temperature dependence of anti-polar state and structural transition further hint that the stability of the anti-polar state is controlled by the BiFeO3 layer thickness within the stacking and, in a more moderate way, by interlayer strain. Discovery of such polar arrangement in superlattices and the possible generalization to the whole rare-earth family pave the way to new platforms for energy storage application as well as nano-electronic devices.
Status of GGOS JWG3 on Improved understanding of space weather events and their monitoring
Creators: name: Garcia-Rigo, Alberto
name: Soja, Benedikt
name: GGOS's JWG3 Team
Publisher: name: ETH Zurich
Year: 2021

description: The JWG3 aims at investigating different approaches to monitor space weather events using the data from different space geodetic techniques and, in particular, combinations thereof. Simulations will also be considered since these could be beneficial to identify the contribution of different techniques and prepare for the analysis of real data. Different strategies for the combination of data are also to be investigated, in particular the weighting of estimates from different techniques in order to increase the performance and reliability of the combined estimates.

Furthermore, existing algorithms for the detection and prediction of space weather events shall be explored and improved to the extent possible. Additionally, the geodetic measurement of the ionospheric electron density will be complemented by direct observations from the Sun gathered from existing spacecraft, such as SOHO, ACE, SDO, Parker Solar Probe, among others. The combination and joint evaluation of multiple datasets from different space geodetic observation techniques (e.g., geodetic VLBI) is still a great challenge. In addition, other indications for solar activity - such as the F10.7 index on solar radio flux, SOLERA as EUV proxy or rate of Global Electron Content (dGEC), provide additional opportunities for comparisons and validation.

As per JWG3 objectives, these include the identification of the key parameters useful to improve real time/prediction of ionospheric/plasmaspheric VTEC, Ne estimates, as well as ionospheric perturbations, in case of extreme solar weather conditions. In general, we are on the way to gain a better understanding of space weather events and their effect on Earth’s atmosphere and near-Earth environment.

"GGOS's JWG3 - Improved understanding of space weather events and their monitoring" team:
Alberto Garcia-Rigo, Benedikt Soja et al.
description: EGUsphere
Supplementary Material for: Hospitalisations with Hidradenitis Suppurativa: An Increasing Problem That Deserves Closer Attention
Creators: name: Santos, J.V.
name: Lisboa, C.
name: Lanna, C.
name: Costa-Pereira, A.
name: Freitas, A.
Publisher: name: Karger Publishers
Year: 2016
Subjects: Medicine

description: Background/Aims: Hidradenitis suppurativa (HS), a chronic inflammatory skin disease of the hair follicle, can lead to scarring and disability. With an estimated European prevalence of 1%, few epidemiological studies of HS have been performed, and none focused on hospitalisations. We aimed to study the time trends of HS hospitalisations and to evaluate the demographic characteristics, hospital incidence rate, readmissions, length of stay, comorbidities and risk factors of hospitalised HS patients. Methods: We performed a retrospective observational study using a national administrative database in Portugal, with discharges between 2000 and 2014. All the inpatients aged 5 years or more with a diagnosis of HS were included. Variables analysed were age, sex, admission and discharge date, discharge outcome and diagnoses. Results: A total of 1,177 patients were hospitalised in this time period (48 were aged 18 years or younger) with a male-to-female ratio of 1:1.17. There was a hospital incidence rate of 0.83 patients with HS per 100,000 person-years (95% CI = 0.78-0.88). The age group with the highest incidence rate was 20-29 years among women and 40-49 years among men. We recorded an increasing trend in the number of new hospitalised patients and in the hospital incidence rate of HS. Tobacco was the most common comorbidity/risk factor. Eighty-three percent of our population underwent HS surgery. Conclusion: This hospital-based incidence study showed that admission for HS is increasing and that the majority of the HS inpatients were surgical cases. In the future, prospective studies will be important to assess risk factors for hospitalisations and complications.
Network expansion of genetic associations defines a pleiotropy map of human cell biology
Creators: name: Barrio-Hernandez, Inigo
name: Schwartzentruber, Jeremy
name: Shrivastava, Anjali
name: del Toro, Noemi
name: Zhang, Qian
name: Bradley, Glyn
name: Hermjakob, Henning
name: Orchard, Sandra
name: Dunham, Ian
name: Anderson, Carl A.
name: Porras, Pablo
name: Beltrao, Pedro
Publisher: name: ETH Zurich
Year: 2021

description: Proteins that interact within molecular networks tend to have similar functions and when perturbed influence the same organismal traits. Interaction networks can be used to expand the list of likely trait associated genes from genome-wide association studies (GWAS). Here, we used improvements in SNP-to-gene mapping to perform network based expansion of trait associated genes for 1,002 human traits showing that this recovers known disease genes or drug targets. The similarity of network expansion scores identifies groups of traits likely to share a common genetic basis as well as the biological processes underlying this. We identified 73 pleiotropic gene modules linked to multiple traits that are enriched in genes involved in processes such as protein ubiquitination and RNA processing. We show examples of modules linked to human diseases enriched in genes with pathogenic variants found in patients or relevant mouse knock-out phenotypes and can be used to map targets of approved drugs for repurposing opportunities. Finally, we illustrate the use of the network expansion scores to study genes at inflammatory bowel disease (IBD) GWAS loci, and implicate IBD-relevant genes with strong functional and genetic support.
description: bioRxiv