Additional file 1 of Age-dependent favorable visual recovery despite significant retinal atrophy in pediatric MOGAD: how much retina do you really need to see well?
Creators: name: Havla, Joachim
name: Pakeerathan, Thivya
name: Schwake, Carolin
name: Bennett, Jeffrey L.
name: Kleiter, Ingo
name: Felipe-Rucián, Ana
name: Joachim, Stephanie C.
name: Lotz-Havla, Amelie S.
name: Kümpfel, Tania
name: Krumbholz, Markus
name: Wendel, Eva M.
name: Reindl, Markus
name: Thiels, Charlotte
name: Lücke, Thomas
name: Hellwig, Kerstin
name: Gold, Ralf
name: Rostasy, Kevin
name: Ayzenberg, Ilya
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Additional file 1: Supplementary Figure 3: Flow chart of patients included in the study. During the study period 64 MOGAD patients were identified in participating centers. Five patients were excluded due to incomplete examination data (n=2) or an acute ON at the time of examination (n=3). Depending on the age of manifestation patients were divided into 2 groups: group (1) 20 MOG-IgG-positive patients with initial manifestation &lt; 18 years (MOGADped) and group (2) 39 MOG-IgG-positive patients with initial manifestation ≥ 18 years (MOGADadult). Supplementary Figure 4: Beeswarm plots showing the distribution of pRNFL G thickness (A), GCIPL volume (B), HCVA (C) and 2,5% LCVA (D) in MOGADped-ON and MOGADadult-ON. Despite profound neuroaxonal retinal atrophy in both groups, MOGADadult-ON eyes showed significantly worse visual outcome (HCVA and 2,5% LCVA) in comparison to MOGADped-ON. Supplementary Figure 5: Scatterplots of VEP P100 latency (A) and number of previous ON (B) against visual outcome (HCVA and 2,5% LCVA). Neither the number of previous ON nor P100-latency correlated with HCVA (rho=0.030 CI95% -0.288 -0.152, p=0.840 [number of previous ON] and rho=-0.028 CI95% -0.354 -0.290, p=0.851 [VEP P100 latency]) or LCVA (rho=-0.237 CI95% -0.422 -0.106, p=0.104 [number of previous ON] and rho=-0.263 CI95% -0.503 -0.078, p=0.071 [VEP P100 latency]). Supplementary Table 3: Demographic and main clinical characteristics of pediatric and adult cohorts with ON history (MOGAD-ON). Abbreviations: MOGAD myelin oligodendrocyte glycoprotein-antibody-associated disease, ON optic neuritis, SD standard deviation. Supplementary Table 4. Comparison of all OCT and VEP measures as well as visual acuity between in ON- and non-ON-eyes in pediatric and adult MOGAD patients. Abbreviations: MOGAD-ON eyes with a history of ON, MOGAD-NON eyes without history of ON, pRNFL peripapillary retinal nerve fibre layer (G global, S superior, l inferior, T temporal, N nasal, PMB papillomacular bundle, N/T nasal/temporal ratio), TMV total macular volume, mRNFL macular RNFL, mGCIPL macular ganglion cell and inner plexiform layer, mINL macular inner nuclear layer, mOPONL macular outer plexiform and outer nuclear layer, HCVA high-contrast, LCVA low-contrast visusal acuity. pRNFL thickness in μm and macular volumes in mm3, VEP P100 latency in ms, VEP amplitude in uV, VA in number of correctly stated letters. GEE analysis: B regression coefficient, p-value: significant results p &lt; 0.05 are indicated in bold letters.