cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Enhancing the retrieval, understanding, and use of clinical evidence at the point of care
Creators: name: Agoritsas, Thomas
Publisher: name: Université de Genève
Year: 2017
Subjects: info:eu-repo/classification/ddc/618.97
Evidence-Based Medicine
Guidelines
Critical Appraisal
Decision Aids
Decision Support Systems
Clinical Epidemiology.

description: Since its birth about 20 years ago, Evidence-Based Medicine (EBM) has changed the way we teach and practice medicine. Yet, despite its large uptake and numerous developments, important gaps remain in the transfer of knowledge to the point-of-care. Clinicians still face major challenges, particularly in: (1) retrieving current best evidence, (2) understanding it, and then (3) using it in their daily practice in clinical encounters with patients. In this Privat-Docent thesis we outline some of the progress that EBM has made in these fields, as well as current limitations. We then present a compilation of 3 of our published manuscripts, each addressing specific aspects of these challenges. In the first article (evidence retrieval), we designed 15 search strategies in PubMed, and tested them on 30 clinical questions, for which a Cochrane Systematic Review defined the gold standard for the set of relevant articles to find. We identified search strategies that can help clinicians retrieve manageable-sized and relevant outputs and thus more easily spot sound evidence to answer their clinical questions. The second article (understanding the evidence) addressed one specific issue related to how clinicians understand diagnostic tests accuracy, and manage the task of updating their pre-test probability of the disease into post-test probability. Using a hypothetical scenario in which we randomized pre-test probability, we found that only about 10% of them seem able to correctly perform this task. Finally, the third paper (evidence use) reports on our attempt to translate evidence summaries using the GRADE methodology into consultation decision aids to support shared decision making between patients and clinicians. We implemented our framework and tools on our online authoring and publication platform (the MAGICapp – www.magicapp.org) and provided a proof-of-concept of how the production of tools for shared decision making can be streamlined and better linked with the evidence.
Additional file 1: of Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)
Creators: name: Zhong, Li
name: Wang, Zongqi
name: Wang, Daxin
name: Wang, Zhe
name: Martens, Yuka
name: Wu, Linbei
name: Xu, Ying
name: Wang, Kai
name: Li, Jianguo
name: Huang, Ruizhi
name: Can, Dan
name: Xu, Huaxi
name: Bu, Guojun
name: Chen, Xiao-Fen
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Figure S1. Oligomeric Aβ1–42 specifically binds to TREM2. Figure S2. Oligomeric Aβ1–42 specifically activates TREM2 reporter cells. Figure S3. The number of microglia clustered around Aβ is decreased in Trem2-KO mice. (PDF 1369 kb)
Evolution of urogenital and breast imaging: from morphology to functional imaging
Creators: name: Botsikas, Diomidis
Publisher: name: Université de Genève
Year: 2017
Subjects: info:eu-repo/classification/ddc/616.0757

description: Urogenital and breast imaging plays a significant role in patient care in oncological and patients with other pathologic conditions. Despite the fact that the spectrum of pathologies is huge, in most domains, evolution of imaging allowed a transition from pure morphological studies towards more sophisticated techniques that allow tissue characterisation and incorporate functional information. In the following pages some of these evolutions will be described. The role of new CT techniques will be particularly discussed. Dual-energy CT (DECT) and its application in oncological and non-oncological urinary tract pathologies as well as in adrenal lesions characterisation will be presented. New CT techniques for exploration of urogenital fistulas, using functional information will be detailed. In another chapter, the evolution towards functional breast imaging will be discussed, with special mention of the role of multiparametric MR (MP-MR) and PET/MR in staging of breasts cancer patients.
Beyond the canonical model of amyloid cascade – a complex network of the regulatory mechanisms implicated in brain aging and Alzheimer's disease
Creators: name: Lazarczyk, Maciej
Publisher: name: Université de Genève
Year: 2017
Subjects: info:eu-repo/classification/ddc/616.89

description: This thesis describes the complex network of regulatory mechanisms implicated in brain aging and Alzheimer's disease (AD). Specifically, it focuses on those regulatory mechanisms that, whilst not being traditionally attributed to amyloid cascade, may still be critical for the determination of individual cognitive trajectories upon aging. The thesis consists of four articles which are preceded by a short introduction and succeeded by a section of concluding remarks. The first article presents the conceptual framework of AD. It describes the evolution of the AD model over time and discusses the role of different compensatory mechanisms in the pathogenesis of AD. Notably, the strengths and limitations of Jack's dynamic AD model are discussed in detail. Articles 2 to 4 offer some examples of regulatory mechanisms that, acting beyond amyloid cascade, affect brain aging and which therefore may be relevant to AD. Namely, they reveal the role of inflammatory regulators (article 2) and genetic background (articles 3 and 4) in the progression of neurodegeneration process. Specifically, article 2 concerns the role of major histocompatibility complex I (MHCI) in the maintenance of synaptic integrity upon aging while articles 3 and 4 refer to so called ‘tau-negative' or ‘plaquepredominant' AD and discuss the possible implication of chorein and GNA14 genes in the pathogenesis of this rare form of dementia.
Contribution of electro-cortical imaging to neuroscience of aging and cognitive decline
Creators: name: Deiber Ibanez, Marie-Pierre
Publisher: name: Université de Genève
Year: 2017
Subjects: info:eu-repo/classification/ddc/616.89
Aging
Cognitive decline
Mild Cognitive Impairment
Alzheimer's Disease
Visual attention
Working memory
Electroencephalography
Event-Related Potentials
Oscillatory activity

description: The present thesis explores the electroencephalographic (EEG) patterns associated with attention and working memory functions in normal aging and in patients with moderate cognitive decline possibly precursor of Alzheimer's disease. Across five studies published between 2009 and 2015, we examine the surface EEG fluctuations generated by visual perception and cognitive processing in the form of 1) event-related potentials (ERPs), reflecting postsynaptic potentials of cortical neural populations, and 2) patterns of brain oscillations between 4 and 30 Hz, including theta (4-7.5 Hz), alpha (8-13 Hz) and beta (14-30 Hz) frequency bands, corresponding to rhythmic synchronizations of neuronal discharges in specific cell assemblies. Overall, these studies evidence various specific functional perturbations associated with cognitive activation in older adults and patients with cognitive deficits, demonstrating the capacity of electrophysiological indices to provide sensitive measures of brain function in normal aging and cognitive decline.
Additional file 7 of A new immune signature for survival prediction and immune checkpoint molecules in lung adenocarcinoma
Creators: name: Guo, Dina
name: Wang, Mian
name: Zhihong Shen
name: Jiaona Zhu
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 7: Table S5. Multivariate Cox analyses of our immune signature in early-stage lung adenocarcinoma (LUAD).
The lost comedian (a novel) & beyond the latticed view: translating self, memory and place in a second language (exegesis)
Creators: name: Evangelista, Elin-Maria Christina
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The thesis consists of two parts, a creative component and an accompanying exegesis. My novel, The Lost Comedian, explores a young girl’s struggle to find her own moral compass through a religious crisis, her relationships with her peers and with adults in positions of power. It is mainly set in Sweden in the 1960s and 70s, but also moves back to the 1930s. By the time of her father’s death, the protagonist, Christina, is living a modest life in bay-side Melbourne. She returns to Sweden from Australia for her father’s funeral, and is confronted with her past and memories of growing up in the religious community of Svenstorp. The novel entwines two themes: 1) Christina’s development from a child with a strong sense of belonging and identity as a “Believer” to a teenage rebel, and the consequences of her rebellion; 2) Christina’s recovery from a secret, deeply personal loss that she has encountered in Melbourne, and the ever-present temptations of surrendering to a sense of guilt, punishment and self-destruction as a consequence of the “pagan” way of life to which she surrendered as a teenager in Sweden. The exegesis, “Beyond the Latticed View: Translating Self, Memory and Place in a Second Language,” focuses on the linguistic and cultural translation processes when writing in a second language. Investigating gains and losses of this translation process, the exegesis explores the prospect of a “new” sense of self emerging in the “new” language. Specific Swedish social, literary and cultural influences that inform the novel are discussed in the context of its setting. The exegesis also examines the cultural translation processes that these influences instigate, and how writing from both a spatial and temporal distance when “translating” the past influences the novel. As well, practical translation issues when writing from an “other” culture and language are explored. While reflecting on the many challenges when writing in translation, the exegesis argues that translating “self, memory and place,” ultimately creates a richly rewarding narrative.
Additional file 2: of Integrative analysis reveals ncRNA-mediated molecular regulatory network driving secondary hair follicle regression in cashmere goats
Creators: name: Zhou, Guangxian
name: Kang, Danju
name: Ma, Sen
name: Wang, Xingtao
name: Gao, Ye
name: Yang, Yuxin
name: Wang, Xiaolong
name: Chen, Yulin
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Virology

description: Summary data output for each sample (DOCX 17Â kb)
Additional file 3: of Integrative analysis reveals ncRNA-mediated molecular regulatory network driving secondary hair follicle regression in cashmere goats
Creators: name: Zhou, Guangxian
name: Kang, Danju
name: Ma, Sen
name: Wang, Xingtao
name: Gao, Ye
name: Yang, Yuxin
name: Wang, Xiaolong
name: Chen, Yulin
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Figure S1. Raw reads classification for each sample (lncRNAs); Figure S2. Mapped region for each sample (lncRNAs);Figure S3. Novel lncRNAs filter. (a) Merged all sample transcripts and remove the chain direction uncertain transcript. Step1, the number of transcripts possessing no less than 2 exons; step 2, the number of transcripts possessing more than 200 bp length; step 3, the left number of transcripts getting rid of known lncRNAs; step 4, the left transcripts which FPKM ≥0.5; step 5, three coding potential screening tools (Coding-Non-Coding-Index, CNCI; Coding Potential Calculator, CPC and Pfam Scan, PFAM) applied to predict novel lncRNAs. (b) A venn diagram for step 5.;Figure S4. LncRNAs targeted genes GO analysis. (a–c) The significant molecular function, biological process and cellular component were enriched by lncRNAs targeted mRNAs in goat skins, and the DAG is the graphical display of GO enrichment results with candidate genes. (d) The number of genes in GO term were showed in histograph. Figure S5. GO analysis of lncRNA-miRNA target mRNAs. (a–c) The significant molecular function, biological process and cellular component were enriched by lncRNA-miRNA-mRNAs in goat skins, and the DAG is the graphical display of GO enrichment results with candidate targeted genes. (d) The number of genes in GO terms were showed in histograph. Figure S6. GO analysis of DE genes. (a–c) The significant molecular function, biological process and cellular component were enriched by DE mRNAs in goat skins, and the DAG is the graphical display of GO enrichment results with candidate targeted genes. (d) The number of genes in GO terms were showed in histograph. Figure S7. The top 20 KEGG pathways of hair cycle in skin. When the rich factor is greater, the Q-value is closer to zero, and the number of genes is greater, then the enrichment is more significant. (PDF 2925 kb)
Additional file 1 of Population structure of five native sheep breeds of Sweden estimated with high density SNP genotypes
Creators: name: Rochus, Christina
name: Jonas, Elisabeth
name: Johansson, Anna
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 1: Figure S1. Map of the origin of Swedish local breeds.
Additional file 1: of A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97
Creators: name: Ramalho-Carvalho, João
name: Gonçalves, Céline
name: Graça, Inês
name: Bidarra, David
name: Pereira-Silva, Eva
name: Salta, Sofia
name: Godinho, Maria
name: Gomez, Antonio
name: Esteller, Manel
name: Costa, Bruno
name: Henrique, Rui
name: Jerónimo, Carmen
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary information. Table S1 Primers and TaqMan assays used in this study; Table S2 microRNAs selected for evaluation in TCGA dataset; Table S3 Putative miR-152 target genes determined by multiple in silico prediction tools; Figure S1 Flow chart depicting the different steps followed to ascertain downregulated miRNAs in PCa; Figure S2 Representative examples of downregulated microRNAs at the TCGA cohort from the initial microRNA profiling by Exiqon; Figure S3 Representative examples of microRNAs downregulated at the TCGA cohort derived from the DNA methylation mapping by 450 K Illumina’s array; Figure S4 Efficiency of miR-152 mimic’s transfection in PCa cell lines; Figure S5 TIDE analysis of deletions/insertions caused by each sgRNA targeting TMEM97. (PDF 4188 kb)
Additional file 5 of Population structure of five native sheep breeds of Sweden estimated with high density SNP genotypes
Creators: name: Rochus, Christina
name: Jonas, Elisabeth
name: Johansson, Anna
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology
subject: Computational Biology

description: Additional file 5: Table S1. Purebred Swedish sheep registered in Elitlamm (2018).
¿Y la neuromodulación para cuándo...? Revisión de los algoritmos diagnósticos del paciente con TOC resistente; a propósito de un caso
Creators: name: Benítez Sánchez, Elena Inmaculada
name: Montesinos Almarcha, Lorena
name: Vega Lucio, Nerea
Publisher: name: Psicosomàtica y Psiquiatría
Year: 2024

description: Psicosomàtica y Psiquiatría, Núm. 28 (2024): enero-febrero-marzo
MOESM1 of pH-responsive theranostic nanocomposites as synergistically enhancing positive and negative magnetic resonance imaging contrast agents
Creators: name: Huang, Xi
name: Yuan, Yaping
name: Ruan, Weiwei
name: Liu, Lianhua
name: Liu, Maili
name: Chen, Shizhen
name: Zhou, Xin
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 1. Additional figures, experimental details and parameters. Part S1: Preparation of Fe3O4@SiO2@PAA-cRGD; part S2, including the Fig. S1â S11: 1H NMR, 13C NMR, MS, UV spectra and structure for compounds; part S3: Cell culture; part S4: Specific parameters of MR contrast properties test; part S5, including Table S1 and Fig. S12â 16: Hydrodynamic diameters of the nanoparticles tested by DLS; part S6: Drug loading and in vitro release; part S7, including Fig. S17: Biodistributions tested by ICP-MS.
Prehospital pain: epidemiology and management in Victoria, Australia
Creators: name: Jennings, Paul Andrew
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Pain is a commonly encountered condition in the prehospital and emergency medicine settings, and is associated with significant burden of disease. This thesis explores the epidemiology of pain in the Victorian prehospital setting, and factors associated with the likelihood of clinically important pain severity reduction were identified from the interrogation of a large patient record database. Seven factors were found to be associated with the likelihood of clinically important pain reduction following multivariate analyses. These included: age, time criticality of the patient, pain aetiology, initial pain severity, analgesic agent or combination administered to the patient, scene time, and transport time. In 2007, ketamine was trialled in the prehospital setting as an analgesic agent. In this prospective, randomised controlled trial, the administration of morphine followed by ketamine was found to be superior to morphine alone in the reduction of pain intensity in adult patients with moderate to severe pain following trauma in the prehospital setting. Intravenous ketamine provided safe and effective analgesia to adult patients following injury. After accounting for differences between trial cluster sites, patients in the ketamine group had a mean verbal numerical rating scale (VNRS) pain reduction of 5.6 points compared with the M-group of 3.2 points (p<0.0001). This study followed participants up to 12 months following enrolment into the ketamine study, identified those who continued to suffer from persistent pain, and assessed their health-related quality of life using the SF-36 questionnaire. Statistically and clinically, there was no difference in the long term follow up between study groups with respect to the summary measures, subscale measures or global pain score. In light of the superiority of intravenous ketamine over morphine to reduce pain intensity in patients with moderate to severe traumatic injury, this agent warrants consideration by all emergency medical services (EMS) who have appropriate training and clinical governance. Furthermore, ketamine was administered in a safe manner in this non-physician EMS setting. It is likely that this work will result in Ambulance Victoria introducing ketamine as an alternative analgesic agent for the prehospital management of moderate to severe pain in trauma patients, and has the potential to influence change in EMS and emergency medicine practice nationally and internationally. In time, hopefully, these studies will make a major contribution to the early management of injured patients. Improved early management of pain and interventions aimed at other related factors could lead to more efficient rehabilitation, demonstrable decreases in morbidity, and improved quality of life.
Additional file 1: of Nutrition assessment of vitamin A and vitamin D in northeast Chinese population based-on SPE/UPLC/PDA
Creators: name: Wang, Maoqing
name: Chen, Hongyu
name: Du, Shanshan
name: Guo, Xinxin
name: Zhao, Jiali
name: Sun, Changhao
name: Li, Ying
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences

description: Table S1. TQ MS condition of detecting of serum retinol and 25OHD3. Figure S1. Calibration graphs for retinol and 25OHD3. Figure S2. Plots of the percentage difference in 25OHD3 and retinol concentrations measured in ULPC/PDA by UPLC/MS-MS. (DOCX 125Â kb)
Additional file 10: of Identification of cold stress responsive microRNAs in two winter turnip rape (Brassica rapa L.) by high throughput sequencing
Creators: name: Zeng, Xiucun
name: Xu, Yaozhao
name: Jiang, Jinjin
name: Zhang, Fenqin
name: Ma, Li
name: Wu, Dewei
name: Wang, Youping
name: Sun, Wancang
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Plant Biology
subject: Virology

description: Table S7. Differentially expressed miRNAs between two varieties (DOC 41Â kb)
Cultural memory and literature: re-imagining Australia’s past
Creators: name: Molloy, Diane Leah
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: This thesis sets out to demonstrate that literature that uses dialogic and syncretic methods to describe a collectively shared experience contributes to cultural memory by recalling the absent and the forgotten and by proposing alternative ways to access and represent the past. I further argue that the intertextual nature and memory work of the texts I evaluate as memorial novels build a complementary and reciprocal relationship with each other and with other texts that respond to Australia’s past to allow for the growth and dispersal of meaning. Understanding how literature contributes to cultural memory has significance for contemporary understandings of Australian culture. As literature is involved in a continuous looping back to establish and reinforce cultural memory I argue that it takes a particular type of literature to challenge the common opinion and to insert into cultural memory alternative voices and stories, rather than reinforce official culture that insists on fixed or hierarchical forms and adheres to strict boundaries between genres. Following shifts in historical consciousness and theoretical debates about memory in the nineteen-eighties and nineties, there was a corresponding shift in Australian novels that respond to our past, particularly our violent past. The result was a number of what I call memorial novels, novels that articulate the interplay of history, trauma and memory in an effort to move beyond the familiar and the universal, to step outside official history, language and modes of storytelling, and through a process of reimagining the past recognise and expose narrative and linguistic frames of remembrance, and sometimes propose new ways of remembering. I use Renate Lachmann’s theory of cultural memory and intertextuality to trace the way the mechanisms of forgetting and remembering in literature construct cultural memory and how literature as a memory medium recalls previously silenced knowledge, restores outdated knowledge and reintegrates knowledge that was once considered unofficial, such as oral history and family memories as well as those aspects of the past that had been silenced, forgotten or misunderstood. The narratives are pluralist, ambivalent, heterogeneous and unresolved as narrators and characters re-imagine the past to transgress the traditional boundaries of form and content. Memorial novels rely less on the common polarities of good and evil, left and right, and black and white and recognise that Australian culture has “layers of identity” that can exist in a “pluralist and united world” (Pearson, “White Guilt” 245). History, trauma and memory come together in narratives that use hybrid storytelling modes to re-imagine the past, celebrate survival and offer hope for the future. To support my thesis I present a new evaluation of some well known Australian texts and evaluate some more recent texts against my definition of the memorial novel.
Exploring the synergies between electronic material measurements and modeling
Creators: name: M.Celuch, M.Olszewska-Placha
Publisher: name: Zenodo
Year: 2020
Subjects: MMAMA, EU project, H2020

description: Despite bilateral links, the two worlds of material measurements and computer modelling are mostly advanced by separate groups of researchers. In this talk, we report our works within the European H2020 MMAMA project, aiming to bring the two worlds closer together. We focus on the resonant methods of dielectric measurements and present new models (e.g. industrial CAD formats translated into conformal FDTD meshes) and simulation procedures (e.g. near-field-imaging) that support their understanding (of e.g. SPDR and SiPDR techniques) and developments (e.g. downscaling of surface scans). We discuss grid-search workflows that help illustrate sensitivities to material data.
Understanding job dissatisfaction and burnout amongst student affairs professionals and its relation to student success
Creators: Laurel Wilkie
Publisher: name: University of Alberta Library
Year: 2022

Student affairs professionals are crucial in supporting student success in post-secondary

education. There are a multitude of factors that can impact a student affairs professional’s ability

to provide excellent and consistent support to students. This written work seeks to assess how

burnout and job dissatisfaction impacts student affairs professionals’ ability to support student

success and some potential mediating factors or strategies to move forward. Through reviewing

literature around burnout, job dissatisfaction, and student success this piece hopes to highlight

ways for individuals, workplaces, as well as institutional policies to combat issues of burnout and

job dissatisfaction amongst student affairs professionals. Providing support to their support staff

can allow post-secondary institutions to continue to support students and staff to thrive and

succeed.
Additional file 1: of Identification of cold stress responsive microRNAs in two winter turnip rape (Brassica rapa L.) by high throughput sequencing
Creators: name: Zeng, Xiucun
name: Xu, Yaozhao
name: Jiang, Jinjin
name: Zhang, Fenqin
name: Ma, Li
name: Wu, Dewei
name: Wang, Youping
name: Sun, Wancang
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Virology

description: Table S1. Primers for qRT-PCR analysis of differentially expressed miRNAs (DOCX 14Â kb)
Additional file 1: of Circulating osteopontin and its association with liver fat content in non-obese women with polycystic ovary syndrome: a case control study
Creators: name: Wang, Yuying
name: Zhou, Wei
name: Wu, Chunhua
name: Zhang, Yi
name: Lin, Tzuchun
name: Sun, Yun
name: Liu, Wei
name: Tao, Tao
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Virology

description: Supplementary Tables. (DOCX 21 kb)
Stage I Registered Report
Creators: name: Zaharieva, Martina
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Developmental Psychology
subject: Experimental Analysis of Behavior
subject: Child Psychology
subject: Cognitive Psychology
subject: Cognition and Perception
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: In-principle accepted Stage 1 Registered Report Study describing the background, hypotheses, and analysis plan for the systematic review and meta-analysis.
Additional file 1: of Assessing the outcomes of everolimus on renal angiomyolipoma associated with tuberous sclerosis complex in China: a two years trial
Creators: name: Cai, Yi
name: Guo, Hao
name: Wang, Wenda
name: Li, Hanzhong
name: Sun, Hao
name: Shi, Bing
name: Zhang, Yushi
Publisher: name: figshare
Year: 2018
Subjects: Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Marine Biology
Science Policy

description: Visit Schedule and Assessments. (DOCX 73 kb)
Additional file 2: of Identification of cold stress responsive microRNAs in two winter turnip rape (Brassica rapa L.) by high throughput sequencing
Creators: name: Zeng, Xiucun
name: Xu, Yaozhao
name: Jiang, Jinjin
name: Zhang, Fenqin
name: Ma, Li
name: Wu, Dewei
name: Wang, Youping
name: Sun, Wancang
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mental Health
subject: Plant Biology
subject: Virology

description: Table S2. Primers for qRT-PCR analysis of target genes of differentially expressed miRNAs (DOC 32Â kb)
A study on foraging behavior of swarm robots using reinforcement learning techniques
Creators: name: Mohan, Yogeswaran
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Swarm robotics is the study of how large number of relatively simple physically embodied agents can be designed such that a desired collective behavior emerges from the local interactions among agents and between the agents and the environment. It is a novel approach to the coordination of large numbers of robots. It is inspired from the observation of social insects such as ants, termites, wasps and bees which stand as fascinating examples of how a large number of simple individuals can interact to create collectively intelligent systems. Social insects are known to coordinate their actions to accomplish tasks that are beyond the capabilities of a single individual: termites build large and complex mounds, army ants organize impressive foraging raids and ants can collectively carry large preys. Such coordination capabilities are still beyond the reach of current multirobot systems. In this research, most recent developments of swarm robot systems are addressed by classifying the primary research axes in terms of principal topic areas that have generated significant levels of research. Specific research scopes in each of primary research axes are also classified and the key open issues in this research scopes are identified. With the goal of bringing some objective grounding to the important areas of the mentioned research scopes, this dissertation presents an empirical analysis on multi-agent foraging task using reinforcement learning algorithms. Foraging task is one of the mostly used test applications in multi-agent systems. The aim of agents in foraging task is to find the pucks (prey) and bring them to the home (nest) location in a environment while satisfying the given constraints. This task is also known as prey retrieval task. Reinforcement learning is used to tackle the modeled multi-agent foraging task. Reinforcement learning has been extensively used in many applications such as industrial control, time sequence prediction, robot soccer competition and more. In this thesis, a multi-agent foraging task is modeled using Webots (1996) simulation software and the reinforcement learning algorithms and policies are tested. One of the challenges that arise in reinforcement learning is the exploration and exploitation dilemma. A novel learning policy (FIFO-list learning policy) is proposed and compared against the available learning policies reported in the literature to tackle the exploration and exploitation dilemma. An improved reinforcement learning algorithm (Cautious-Q learning algorithm) is also proposed and the performance is compared with the available learning algorithms. The proposed learning algorithm is a combined strategy of on-policy learning and off-policy learning. The improved learning algorithm and the learning policy is implemented on real environment with Khepera 2 mobile robots and results are presented.
Additional file 2: of Assessing the outcomes of everolimus on renal angiomyolipoma associated with tuberous sclerosis complex in China: a two years trial
Creators: name: Cai, Yi
name: Guo, Hao
name: Wang, Wenda
name: Li, Hanzhong
name: Sun, Hao
name: Shi, Bing
name: Zhang, Yushi
Publisher: name: figshare
Year: 2018
Subjects: Medicine
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Developmental Biology
Marine Biology
Science Policy

description: Physicianâ s Global Assessment of Clinical Condition. (DOCX 98 kb)
Sensory neuroprostheses: from physiology to clinical application
Creators: name: Perez Fornos, Angelica
Publisher: name: Université de Genève
Year: 2017
Subjects: info:eu-repo/classification/ddc/616.8
Cochlear implant
Retinal implant
Vestibular implant
Deafness
Blindness
Bilateral vestibulopathy
Bilateral vestibular loss
Psychophysics
Electrical stimulation
Sensory neuroprosthesis
Perception
Neurosensory deficits
Sensory physiology

description: Our senses are the main information channels through which we perceive and interact with the world. Consequently, patients suffering from severe sensory disabilities are limited at numerous levels of physical and social functioning. This has motivated the development of a novel therapeutic alternative: sensory neuroprostheses. In order to restore lost function, sensory neuroprostheses attempt to take advantage of the information transfer pathway common to all senses: (1) transduction of the physical stimulus by sensory receptors, (2) transmission of relevant information to the primary sensory areas in the brain by sensory afferents, and (3) analysis and integration of the information to generate perception and action. Neurosensory deficits might occur upon damage of any of the structures involved in the process. However, damage to the peripheral sensory receptor can be often the cause of neurosensory loss. Sensory neuroprostheses attempt to “replace” the malfunctioning or missing peripheral sensory organ by directly delivering basic sensory information to the brain using electrical currents. If the prosthesis is able to deliver enough consistent information, the brain will correctly interpret it and useful rehabilitation can be achieved. I have had the opportunity to contribute to this multidisciplinary field at diverse aspects of the development of retinal, cochlear, and vestibular implants. I have chosen to present the main challenges related to the implementation of these devices as a step-to-step approach in the form a collection of selected articles: (1) sensory information should be efficiently delivered to peripheral afferents (Chapter 2); (2) then the expected physiological response can be evoked and quantified (Chapter 3); (3) the restoration of basic sensory abilities can lead to useful rehabilitation in meaningful every-day activities (Chapter 4); (4) however, sensory pathophysiology can fundamentally limit our ability to transmit the appropriate message to the brain (Chapter 5). Finally, Chapter 6 presents the good clinical outcomes that can be achieved, highlighting the importance of proper technical and rehabilitation follow-up. To conclude, in Chapter 7 the present and future of sensory neuroprostheses will be discussed. This will specifically include current clinical and technical challenges, future prospects, as well as the potential of these devices of improving our fundamental knowledge of sensory physiology and neurosensory deficits.
Additional file 1: of miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis
Creators: name: Li, Xiaowei
name: Jiang, Mingzuo
name: Chen, Di
name: Xu, Bing
name: Wang, Rui
name: Chu, Yi
name: Wang, Weijie
name: Zhou, Lin
name: Lei, Zhijie
name: Nie, Yongzhan
name: Fan, Daiming
name: Shang, Yulong
name: Wu, Kaichun
name: Liang, Jie
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Virology

description: Table S6. The sequences of siRNAs and primers. (DOCX 17 kb)
Improving outcomes in community-acquired pneumonia
Creators: name: Garin, Nicolas
Publisher: name: Université de Genève
Year: 2018
Subjects: info:eu-repo/classification/ddc/618.97
Lung infection
Prognosis
Infection
Antibiotics
Corticosteroids

description: Community-acquired pneumonia (CAP) has an annual incidence of 2 to 10‰ that increases with advancing age. Depending on pathogen- and host-related factors, the course of CAP varies from a mild affection treated in the ambulatory setting, to a devastating form complicated by septic shock, respiratory failure, and death. A number of pathogens cause CAP, the most frequent being typical bacteria (Streptococcus pneumoniae, Hemophilus influenza), atypical bacteria (Mycoplasma pneumoniae, Legionella sp.), and viruses. However, the infecting agent is rarely known at the onset of the disease and is not identified at all in half to two-third of cases, so the antibiotic treatment is mostly empiric. Because of its frequency and occasional severity, CAP carries a substantial burden, both for affected individuals and for health systems. CAP is also one of the most frequent reasons for antibiotic prescriptions, and policy decisions concerning the recommended empiric treatment can have a major impact on antibiotic resistance. Unsettled issues relate to the need for covering atypical bacterial pathogens in all patients, and multidrug-resistant bacteria in patients with specific risk factors. No breakthrough therapy has emerged since the introduction of antibiotics eighty years ago, though progresses in life sustaining techniques have probably improved the prognosis of the most severely affected patients. Blunting the host inflammatory response to reduce associated damages without compromising the clearance of the infecting pathogen is one of the most researched issues. Adjunctive corticosteroid therapy is promising and hastens the resolution of symptoms, but safety concerns have not been completely ruled out. Future research efforts should lead to better understanding of the role of lung microbiome in the development and evolution of the disease; in better definition of the potential of modifying the inflammatory response to improve short- and long-term prognosis; and in the development of refined diagnosis tools and algorithms to avoid under- and overdiagnosis or under- and overtreatment.
Developing and utilizing a mini food powder production facility to produce industrially relevant particles for functionality testing
Creators: name: Rogers, Samuel Andrew
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: In this thesis is presented research relating to a monodisperse droplet dryer for production of milk powder. The development and testing of several monodisperse droplet generators and lab-scale spray dryers was carried out. Furthermore, a number of down-scaled techniques for quality measurement were devised for analysis of the powder. Sufficient amounts of highly uniform powder could be dried to low moisture contents, using a range of feed solids concentrations and drying air temperatures. A single droplet drying model was created to simulate the situation, based on established mass and heat transfer equations and material specific kinetics using the Reaction Engineering Approach. Through a series of experiments varying drying temperature and feed solids content for a number of feed materials, the model was validated and its limits of accuracy were established. It successfully predicted the true final moisture contents and insolubilities in a range of conditions. The known and uniform temperature history and the regular particle sizes were then used to conduct original research on the formation of insoluble material during powder heat damage and the formation of particle morphology and shrinkage. Work was also done on spray freeze drying, thin layer drying, powder wetting, dissolution and the addition of surfactants.
The Heart, victim of the liver: evidence by imaging
Creators: name: Hachulla-Lemaire, Anne-Lise
Publisher: name: Université de Genève
Year: 2017
Subjects: info:eu-repo/classification/ddc/616.0757
Cirrhotic cardiomyopathy
Hepatopulmonary syndrome
Portopulmonary hypertension
High-output heart failure
Liver dysfunction
Porto-systemic shunting
Vasoactive imbalance

description: The liver and the heart are closely related organs connected by large vessels. Thus, the heart may be affected by liver diseases, leading to cardiac overload, pulmonary hypertension or high-output heart failure. Severe or chronic liver diseases may result in several heart or pulmonary complications independent of any other existing cardiac or lung diseases in the patient. The major causes are cirrhosis, non-cirrhotic portal hypertension, congenital portosystemic shunts, hereditary haemorrhagic telangiectasia and congenital liver hemangioma. These liver diseases lead to various degrees of cirrhotic cardiomyopathy, vasoactive imbalance or high-flow cardiopathy. High blood flow, shunts and cardiac dilatation predominate on imaging. In the presence of a vasoactive imbalance, the hepatopulmonary syndrome and portopulmonary hypertension must be differentiated. The aim of this review was to describe the diagnostic and imaging features of heart and lung complications from liver diseases.
Additional file 3: of Assessing the outcomes of everolimus on renal angiomyolipoma associated with tuberous sclerosis complex in China: a two years trial
Creators: name: Cai, Yi
name: Guo, Hao
name: Wang, Wenda
name: Li, Hanzhong
name: Sun, Hao
name: Shi, Bing
name: Zhang, Yushi
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology

description: Mutations detected by next-generation sequencing. (DOCX 92 kb)
Stereoselective Polar Radical Crossover for the Functionalization of Strained-Ring Systems
Creators: name: Didier, Dorian
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 340503
subject: Organic chemical synthesis

description: Radical-polar crossover of organoborates is a poweful tool that enables the creation of two C-C bonds simultaneously. Small ring systems have become essential motifs in drug discovery and medicinal chemistry. However, step-economic methods for their selective functionalization remains scarce. Here we present a one-pot strategy that merges a simple preparation of strained organoboron species with the recently popularized polar radical crossover of borate derivatives to stereoselectively access tri-substituted azetidines, cyclobutanes and five-membered carbo- and heterocycles.
Additional file 2: of miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis
Creators: name: Li, Xiaowei
name: Jiang, Mingzuo
name: Chen, Di
name: Xu, Bing
name: Wang, Rui
name: Chu, Yi
name: Wang, Weijie
name: Zhou, Lin
name: Lei, Zhijie
name: Nie, Yongzhan
name: Fan, Daiming
name: Shang, Yulong
name: Wu, Kaichun
name: Liang, Jie
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Virology

description: Table S1. The expression analysis of Dock6, Dock7 and Dock8 in the Oncomine database (nâ >â 10). (DOCX 18 kb)
Discovery and optimization of Grb7 antagonists as potential antitumor therapeutics
Creators: name: Ambaye, Nigus Dessalew
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The growth factor receptor bound protein 7 (Grb7) is a non‐catalytic adaptor protein that was originally identified as a binding partner of the growth factor receptor (ErbB‐2). Amplification and overexpression of Grb7 is frequently implicated in the development of aggressive, recalcitrant and advanced tumor phenotypes making it a promising target in human cancers. Apart from several peptide‐based experimental antagonists, to date there exist no potent drug that is developed or known to act against Grb7. Thus, the overall objective of the research conducted in this thesis was to design novel, potent, selective and cell permeable Grb7 antagonists that may have potential as antitumor therapeutics. The first part of the thesis deals with optimization studies around a known lead polypeptide designed to bind to the Grb7 SH2 domain. A total of 11 polypeptides were synthesized with a yield varying from 2 to 17%. The peptide antagonists were found to have moderate binding affinity ranging from 0.6 – 60 μM as determined by isothermal titration calorimetry. Moreover, a short 7 residue cell permeablising sequence was incorporated into the inhibitor peptide construct and its ability to translocate peptides across membranes tested in in vitro and cell based assays. The second part of the thesis focused on small molecule antagonist discovery and optimization. Starting from known peptide leads and an experimental structure of the Grb7 SH2 domain, a series of ligand design techniques comprising shape based similarity searches, molecular docking and 2D‐similarity searching was effected to identify non‐peptide antagonists. In total, three structurally distinct classes of small molecular antagonists with moderate in vitro affinity and in vivo activity were identified from the study. The last part of the project reports the crystal structure determination of two Grb7 SH2 domain constructs. High‐resolution crystal structures of the apo‐ and peptide-bound forms of the Grb7 SH2 domain were determined. All together, extensive biophysical, computational and structural analyses were conducted on the Grb7 SH2 domain and ligands that will form the foundation for future Grb7 inhibitor development.