cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
New and emerging drugs for the treatment of acne vulgaris in adolescents
Creators: name: Sousa, Isabel Cristina Valente Duarte De
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Introduction: Acne vulgaris is the most common skin disease worldwide, yet current treatment options, although effective, are associated with unwanted side effects, chronicity, relapses and recurrences. The adequate control of the four pathogenic mechanisms involved in the appearance of acne lesions is key to treatment success. This paper aims to discuss the novel treatment modalities that have surfaced in consequence of new knowledge obtained in acne pathogenesis. Areas covered: Pathogenic pathways are evaluated and discussed throughout the paper in relation to the mechanisms of action of novel molecules being investigated for the treatment of acne vulgaris. A comprehensive search was made in PubMed and Clinicaltrial.gov using a different combination of keywords, which included acne vulgaris, treatment, therapy, and therapeutic. Expert opinion: In the near future, more effective treatments with less side effects are expected. The use of topical anti-androgens, coenzyme-A carboxylase inhibitors, and insulin growth factor-1inhibitors to control sebum production seem promising. Selective RAR-agonists have the potential of becoming an alternative to the currently available retinoid therapy in the management of infundibular dyskeratosis with a better safety profile. Antibiotic use will probably decline as more effective options for controlling Cutinebacterium acnes colonization and the inflammation cascade emerge.
On the origin of TSAR: morphology, diversity, and phylogeny of Telonemia
Creators: name: Tikhonenkov, Denis
name: Jamy, Mahwash
name: Borodina, Anastasia
name: Belyaev, Artem
name: Zagumyonnyi, Dmitry
name: Prokina, Kristina
name: P. Mylnikov, Alexander
name: Burki, Fabien
name: Karpov, Sergei
Publisher: name: figshare
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60302 Biogeography and Phylogeography
subject: Cell Biology
subject: Microbiology

description: VIDEO S1, MP4 file, 1954,425231 MB. Cell division of Arpakorses versatilis. The video is 10 times accelerated. Phase contrast, objective lens 63x, water immersion. VIDEO S2, MP4 file, 111,211972 MB. Feeding of Arpakorses versatilis on bodonids Procryptobia sorokini. Phase contrast, objective lens 20x.
 VIDEO S3, MP4 file, 1095,767477 MB. Feeding of Arpakorses versatilis on bodonid Procryptobia sorokini. DIC, objective lens 63x, water immersion.
 VIDEO S4, MP4 file, 516,157417 MB. Cell division of Telonema papanine. Phase contrast, objective lens 63x, water immersion.
 VIDEO S5, MP4 file, 1478,772827 MB. Feeding on bacteria of Telonema papanine. Phase contrast, objective lens 63x, water immersion. The video is 3 times accelerated.
 VIDEO S6, MP4 file, 268,518002 MB. Moving of Telonema papanine. Cell swims posterior end forward and rotates around the longitudinal axis, the flagella are directed backward. DIC, objective lens 63x, water immersion.
VIDEO S7, MP4 file, 280,004552 MB. Attack by Telonema tenere on individual of its own species. DIC, objective lens x63, water immersion.
Closed-loop cleaning treatment system — resource recovery of coal gangue
Creators: name: Xu, Fanghong
name: Xiao, Jin
name: Ye, Shengchao
name: Liu, Wei
name: Yang, Minge
name: Yao, Zhen
name: Zhong, Qifan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Coal gangue (CG) is one of the main solid wastes emitted by coal mining. It causes severe damage to the environment. CG contains high levels of valuable elements (Al, Si) and has the potential for utilization and clean disposal. Here, an environment-friendly process for separating valuable components from CG was proposed: the closed-loop system of activation-leach-separation. The results show that the decarbonization rate was close to 100% under the optimum conditions of CG particle size of 0.075 mm to 0.15 mm and activated at 800°C for 120 min. Subsequently, it was transformed into a mixed-acid system with a hydrochloric acid (HCl) concentration of 4.5 mol/L, hydrofluoric acid (HF) volume fraction of 15%, and the liquid-solid ratio of 10:1, which achieved excellent separation efficiency. The residual rate of Al in the solution was only 0.7%, and the extraction rate of Si can reach 71.6%. Further, industrial-grade AlF3 products were also recovered. By adding saturated KCl solution and reacting at 33°C for 15 min, Si was further recovered in K2SiF6, and the yield was 85.83%. Particularly, the leaching solution maintained good extraction efficiency in the subsequent three cycles, the yield of K2SiF6 was 88.29%, confirming the feasibility of the closed-loop system. This treatment embodied the environmental-friendly properties of low acid consumption and low effluent discharge, providing a feasible method for clean treatment and resource utilization of CG.
Anisotropic thermodynamics of d-wave superconductors in the vortex state
Creators: name: Vekhter, I.
name: Hirschfeld, P. J.
name: Carbotte, J. P.
name: Nicol, E. J.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We show that the density of states and the thermodynamic properties of a 2D d-wave superconductor in the vortex state with applied magnetic field $\bf H$ in the plane depend on the angle between $\bf H$ and the order parameter nodes. Within a semiclassical treatment of the extended quasiparticle states, we obtain fourfold oscillations of the specific heat, measurement of which provides a simple probe of gap symmetry. The frequency dependence of the density of states and the temperature dependence of thermodynamic properties obey different power laws for field in the nodal and anti-nodal direction. The fourfold pattern is changed to twofold when orthorhombicity is considered.
description: 5 pages, figures included, minor changes, published version
Empagliflozin protects the kidney by reducing toxic ALB (albumin) exposure and preventing autophagic stagnation in proximal tubules
Creators: name: Matsui, Sho
name: Yamamoto, Takeshi
name: Takabatake, Yoshitsugu
name: Takahashi, Atsushi
name: Namba-Hamano, Tomoko
name: Matsuda, Jun
name: Minami, Satoshi
name: Sakai, Shinsuke
name: Yonishi, Hiroaki
name: Nakamura, Jun
name: Maeda, Shihomi
name: Matsumoto, Ayumi
name: Matsui, Isao
name: Yanagita, Motoko
name: Isaka, Yoshitaka
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: The renoprotective effects of SLC5A2/SGLT2 (solute carrier 5 (sodium/glucose cotransporter), member 2) inhibitors have recently been demonstrated in non-diabetic chronic kidney disease (CKD), even without overt albuminuria. However, the mechanism underlying this renoprotection is largely unclear. We investigated the renoprotective mechanisms of the SLC5A2 inhibitor empagliflozin with a focus on ALB (albumin) reabsorption and macroautophagy/autophagy in proximal tubules using wild-type or drug-inducible lrp2/Megalin or atg5 knockout mice with high-fat diet (HFD)-induced obesity or 5/6 nephrectomy that elevated intraglomerular pressure without overt albuminuria. Empagliflozin treatment of HFD-fed mice reduced several hallmarks of lipotoxicity in the proximal tubules, such as phospholipid accumulation in the lysosome, inflammation and fibrosis. Empagliflozin, which decreases intraglomerular pressure, not only reduced the HFD-induced increase in ALB reabsorption via LRP2 in the proximal tubules (i.e. total nephron ALB filtration), as assessed by urinary ALB excretion caused by genetic ablation of Lrp2, but also ameliorated the HFD-induced imbalance in circulating ALB-bound fatty acids. Empagliflozin alleviated the HFD-induced increase in autophagic demand and successfully prevented autophagic stagnation in the proximal tubules. Similarly, empagliflozin decreased ALB exposure and autophagic demand in 5/6 nephrectomized mice. Finally, empagliflozin reduced HFD-induced vulnerability to ischemia–reperfusion injury, whereas LRP2 blockade and atg5 ablation separately diminished this effect. Our findings indicate that empagliflozin reduces ALB exposure and prevents autophagic stagnation in the proximal tubules even without overt albuminuria. Autophagy improvement may be critical for the renoprotection mediated by SLC5A2 inhibition.
Testing Landau gauge OPE on the Lattice with a $$ Condensate
Creators: name: Boucaud, Ph.
name: Yaouanc, A. Le
name: Leroy, J. P.
name: Micheli, J.
name: Pène, O.
name: Rodríguez-Quintero, J.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Using the operator product expansion we show that the $O(1/p^2)$ correction to the perturbative expressions for the gluon propagator and the strong coupling constant resulting from lattice simulations in the Landau gauge are due to a non-vanishing vacuum expectation value of the operator $A^μA_μ$. This is done using the recently published Wilson coefficients of the identity operator computed to third order, and the subdominant Wilson coefficient computed in this paper to the leading logarithm. As a test of the applicability of OPE we compare the $$ estimated from the gluon propagator and the one from the coupling constant in the flavourless case. Both agree within the statistical uncertainty: $\sqrt{< A^μA_μ>} \simeq 1.64(15)$ GeV. Simultaneously we fit $\Lams = $ 233(28) MeV in perfect agreement with previous lattice estimates. When the leading coefficients are only expanded to two loops, the two estimates of the condensate differ drastically. As a consequence we insist that OPE can be applied in predicting physical quantities only if the Wilson coefficients are computed to a high enough perturbative order.
description: 15 pages, LaTex file with 5 figures
Shape staggering of mid-shell mercury isotopes from in-source laser spectroscopy compared with Density Functional Theory and Monte Carlo Shell Model calculations
Creators: name: Sels, S.
name: Goodacre, T. Day
name: Marsh, B. A.
name: Pastore, A.
name: Ryssens, W.
name: Tsunoda, Y.
name: Althubiti, N.
name: Andel, B.
name: Andreyev, A. N.
name: Atanasov, D.
name: Barzakh, A. E.
name: Bender, M.
name: Billowes, J.
name: Blaum, K.
name: Cocolios, T. E.
name: Cubiss, J. G.
name: Dobaczewski, J.
name: Farooq-Smith, G. J.
name: Fedorov, D. V.
name: Fedosseev, V. N.
name: Flanagan, K. T.
name: Gaffney, L. P.
name: Ghys, L.
name: Heenen, P-H.
name: Huyse, M.
name: Kreim, S.
name: Lunney, D.
name: Lynch, K. M.
name: Manea, V.
name: Palenzuela, Y. Martinez
name: Medonca, T. M.
name: Molkanov, P. L.
name: Otsuka, T.
name: Ramos, J. P.
name: Rossel, R. E.
name: Rothe, S.
name: Schweikhard, L.
name: Seliverstov, M. D.
name: Spagnoletti, P.
name: Van Beveren, C.
name: Van Duppen, P.
name: Veinhard, M.
name: Verstraelen, E.
name: Welker, A.
name: Wendt, K.
name: Wienholtz, F.
name: Wolf, R. N.
name: Zadvornaya, A.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Neutron-deficient $^{177-185}$Hg isotopes were studied using in-source laser resonance-ionization spectroscopy at the CERN-ISOLDE radioactive ion-beam facility, in an experiment combining different detection methods tailored to the studied isotopes. These include either alpha-decay tagging or Multi-reflection Time-of-Flight gating to identify the isotopes of interest. The endpoint of the odd-even nuclear shape staggering in mercury was observed directly by measuring for the first time the isotope shifts and hyperfine structures of $^{177-180}$Hg. Changes in the mean-square charge radii for all mentioned isotopes, magnetic dipole and electric quadrupole moments of the odd-A isotopes and arguments in favor of $I = 7/2$ spin assignment for $^{177,179}$Hg were deduced. Experimental results are compared with Density Functional Theory (DFT) and Monte-Carlo Shell Model (MCSM) calculations. DFT calculations with several Skyrme parameterizations predict a large jump in the charge radius around the neutron $N = 104$ mid shell, with an odd-even staggering pattern related to the coexistence of nearly-degenerate oblate and prolate minima. This near-degeneracy is highly sensitive to many aspects of the effective interaction, a fact that renders perfect agreement with experiment out of reach for current functionals. Despite this inherent diffculty, the SLy5s1 and a modified UNEDF1^{SO} parameterization predict a qualitatively correct staggering that is off by two neutron numbers. MCSM calculations of states with the experimental spins and parities show good agreement for both electromagnetic moments and the observed charge radii. A clear mechanism for the origin of shape staggering within this context is identified: a substantial change in occupancy of the proton $πh_{9/2}$ and neutron $νi_{13/2}$ orbitals.
description: 19 pages, 18 figures
title: Εφαρμογές μηχανικής μάθησης στην γονιδιωματική
title: Applications of machine learning in genomics
titleType: AlternativeTitle
Creators: name: Ουλάνη, Αικατερίνη
name: Oulani, Aikaterini
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2024
Subjects: subject: Machine learning
subject: Genomics
subject: Γονιδιωματική
subject: Μηχανική μάθηση
subject: Endometrial cancer

description: Στο συνεχώς εξελισσόμενο τομέα της γονιδιωματικής, ο ρυθμός με τον οποίο αυξάνονται τα δεδομένα έχει φτάσει σε πρωτοφανείς ταχύτητες, εγκαινιάζοντας μία νέα εποχή για την υπολογιστική βιολογία. Αυτή η εκρηκτική αύξηση των γονιδιωματικών δεδομένων, η οποία τροφοδοτείται από την πρόοδο των τεχνολογιών αλληλούχισης DNA, προσφέρει τεράστιες δυνατότητες για την κατανόηση της πολυπλοκότητας της ζωής, από την ανακάλυψη των γενετικών αιτιών διαφόρων νόσων μέχρι την εφαρμογή εξατομικευμένων θεραπειών. Ωστόσο, η τεράστια εισροή αυτών των δεδομένων φέρνει στο φως μεγάλες προκλήσεις όσον αφορά την αποθήκευση, την ανάλυση και την ερμηνεία τους, γεγονός που απαιτεί καινοτόμες λύσεις που αξιοποιούν τις τελευταίες εξελίξεις στη μηχανική μάθηση και την επιστήμη των δεδομένων. Η παρούσα διπλωματική διερευνά τον κρίσιμο ρόλο της εφαρμογής τεχνικών μηχανικής μάθησης στον τομέα της γονιδιωματικής, αντιμετωπίζοντας τις πολυπλοκότητες και τον όγκο των δεδομένων που η παραδοσιακή ανάλυση δεν μπορεί να επεξεργαστεί αποτελεσματικά. Μέσα από μία ολοκληρωμένη μελέτη διάφορων στοιχείων και εννοιών που συνδέονται με τη γονιδιωματική και τη μηχανική μάθηση, καθώς και μέσω της μελέτης εφαρμογών που συναντώνται στη βιβλιογραφία αλλά και της δημιουργίας μίας προσαρμοσμένης εφαρμογής σε πραγματικά γονιδιωματικά δεδομένα, αυτή η διπλωματική εργασία επιδιώκει να συμβάλλει στη διαμόρφωση μίας ολοκληρωμένης εικόνας για τη σημασία της μηχανικής μάθησης στην εξερεύνηση και την εκμετάλλευση των γονιδιωματικών δεδομένων, ανοίγοντας τον δρόμο για περαιτέρω επιστημονικές ανακαλύψεις.
Applications for e-Government : global terrorism analysis
Creators: name: Kapsis, Dimitrios
name: Καψής, Δημήτριος
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2024
Subjects: subject: Big data
subject: Data science
subject: Data analysis
subject: Machine learning
subject: Neural network
subject: Deep neural networks
subject: Terrorism
subject: Terrorist attacks
subject: Terrorist groups
subject: e-Government

description: Η τρομοκρατία έχει μεγάλη επίπτωση στην κοινωνία τόσο στις ζωές των ανθρώπων όσο και στην οικονομία. Πολλές καταστροφικές τρομοκρατικές επιθέσεις έχουν συμβεί παγκοσμίως ανά τα χρόνια, προκαλώντας εκτεταμένες υλικές ζημιές αλλά και την απώλεια ανθρώπινων ζωών. Η Τεχνητή Νοημοσύνη έχει αποδειχθεί ένα πολύ πρακτικό εργαλείο για την αντιμετώπιση αυτού του κινδύνου. Σε αυτήν τη διατριβή μελετώνται δύο βάσεις δεδομένων, το “Global Terrorism Dataset” (GTD), και ένα δεύτερο σύνολο δεδομένων QFactors_Dataset, βασισμένο στο GTD, που περιλαμβάνει και ορισμένα επιπλέον χαρακτηριστικά διαφορετικής φύσης, όπως ο αριθμός των προσφύγων και μεταναστών, η μέση διάρκεια ζωής, το επίπεδο εκπαίδευσης κ.ά. Πάνω σε αυτά, δημιουργούνται και συγκρίνονται διάφορα μοντέλα Βαθιών Νευρωνικών Δικτύων (DNN) για να κατηγοριοποιήσουν τις τρομοκρατικές επιθέσεις, βάση της πολιτικής ταυτότητας που έχουν οι τρομοκρατικές ομάδες. Με αυτόν τον τρόπο εξετάζονται διάφορα χαρακτηριστικά που μπορεί να επηρεάζουν την πρόβλεψη του μοντέλου. Αρχικά, πραγματοποιείται καθαρισμός δεδομένων, και ακολουθεί η προ επεξεργασία τους για να γίνουν κατάλληλα για την εκπαίδευση των μοντέλων. Συγκεκριμένα, ήταν απαραίτητο να μετατραπούν τα λεκτικά δεδομένα (περιοχές, χώρες, τρομοκρατικές ομάδες κλπ.) σε αριθμητικά, καθώς και η κανονικοποίησή τους για να μπορέσουμε έπειτα να χρησιμοποιηθούν στα μοντέλα. Η συλλογή δεδομένων αποτελείται από εγγραφές τόσο για επιτυχημένες όσο και για αποτυχημένες επιθέσεις με χρήση διαφόρων όπλων, μεθόδων επίθεσης και στόχων. Τα μοντέλα λαμβάνουν υπόψιν διάφορους παράγοντες, συμπεριλαμβανομένων, της ημερομηνία της επίθεσης, τη χώρα, την τρομοκρατική ομάδα, τον αριθμό των θανάτων, τον τύπο της επίθεσης μαζί με τα όπλα που χρησιμοποιήθηκαν. Όλοι αυτοί οι παράγοντες αναλύονται στις επόμενες ενότητες.
Anagallis fruticosa Vent., Choix Pl.
Creators: name: Callmander, Martin W.
name: Durbin, Olivier D.
name: Lack, Hans-Walter
name: Bungener, Patrick
name: Martin, Pascal
name: Gautier, Laurent
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Ericales
Primulaceae
Anagallis
Anagallis fruticosa

description: 3. Anagallis fruticosa Vent., Choix Pl.: tab. 14. 1803.
 Lectotypus (designated here): M OROCCO: Mogador [Essaouira], Broussonet s.n. (G [G00341554]!; isolecto-: B-W [B-W 03542-01 0]!, G-DC [G00138354]!).
 = Anagallis monelli L.
 Notes. – Three collections of a single gathering have been located. It represents the specimen collected by Broussonet in Mogador [now Essaouira], Morocco. We know that Delessert and Candolle exchanged herbarium specimens. The Broussonet collection in Ventenat’s herbarium is therefore designated here as the lectotype.
description: Published as part of Callmander, Martin W., Durbin, Olivier D., Lack, Hans-Walter, Bungener, Patrick, Martin, Pascal & Gautier, Laurent, 2017, Etienne-Pierre Ventenat (1757 - 1808) and the gardens of Cels and Empress Joséphine, pp. 87-132 in Candollea 72 (1) on page 97, DOI: 10.15553/c2017v721a8, http://zenodo.org/record/5721919
Nonperturbative Explanation of the Enhancement Factors in QCD Sum Rule for the rho Meson
Creators: name: Nie, Shu-Quan
name: Kuang, Yu-Ping
name: Wang, Qing
name: Yi, Yu-Ping
Publisher: name: arXiv
Year: 1997
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Taking the sum rule for the rho meson as an example, we study the possibility of explaining the phenomenological enhamcement factors for certain terms in the vacuum expectation value of the operator product expansion in the QCD sum rule. We take a QCD motivated extended Nambu-Jona-Lasinio (ENJL) model as the low energy effective Lagrangian for QCD with which we calculate the nonperturbative contributions to the vacuum condensate expansion to obtain the enhancement factors. Our result shows that such nonperturbative contributions can cause large enough enhancement factors which can be consistent with the phenomenological values.
description: 17 pages in RevTex with 5 figures
Additional file 6 of Microbial community structure and composition is associated with host species and sex in Sigmodon cotton rats
Creators: name: Strickland, Britton A.
name: Patel, Mira C.
name: Shilts, Meghan H.
name: Boone, Helen H.
name: Kamali, Arash
name: Zhang, Wei
name: Stylos, Daniel
name: Boukhvalova, Marina S.
name: Rosas-Salazar, Christian
name: Yooseph, Shibu
name: Rajagopala, Seesandra V.
name: Blanco, Jorge C. G.
name: Das, Suman R.
Publisher: name: figshare
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 6: Figure S6. Statistically significant differentially abundant bacteria genera between S. hispidus and S. fulviventer determined by GeneSelector.
Driven interfaces in disordered media: determination of universality classes from experimental data
Creators: name: Albert, Reka
name: Barabasi, Albert-Laszlo
name: Carle, Nathan
name: Dougherty, Andrew
Publisher: name: arXiv
Year: 1998
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: While there have been important theoretical advances in understanding the universality classes of interfaces moving in porous media, the developed tools cannot be directly applied to experiments. Here we introduce a method that can identify the universality class from snapshots of the interface profile. We test the method on discrete models whose universality class is well known, and use it to identify the universality class of interfaces obtained in experiments on fluid flow in porous media.
description: 4 pages, 5 figures
bio_140_12_121006.pdf
Creators: name: Meza, Daphne
name: Rubenstein, David A.
name: Yin, Wei
Publisher: name: Health Research Alliance
Year: 2024
Subjects: classificationCode: 320199
subject: Cardiovascular medicine and haematology not elsewhere classified

description:  A fluid–structure interaction (FSI) model of a left anterior descending (LAD) coronary artery was developed, incorporating transient blood flow, cyclic bending motion of the artery, and myocardial contraction. The three-dimensional (3D) geometry was constructed based on a patient's computed tomography angiography (CTA) data. To simulate disease conditions, a plaque was placed within the LAD to create a 70% stenosis. The bending motion of the blood vessel was prescribed based on the LAD spatial information. The pressure induced by myocardial contraction was applied to the outside of the blood vessel wall. The fluid domain was solved using the Navier–Stokes equations. The arterial wall was defined as a nonlinear elastic, anisotropic, and incompressible material, and the mechanical behavior was described using the modified hyper-elastic Mooney–Rivlin model. The fluid (blood) and solid (vascular wall) domains were fully coupled. The simulation results demonstrated that besides vessel bending/stretching motion, myocardial contraction had a significant effect on local hemodynamics and vascular wall stress/strain distribution. It not only transiently increased blood flow velocity and fluid wall shear stress, but also changed shear stress patterns. The presence of the plaque significantly reduced vascular wall tensile strain. Compared to the coronary artery models developed previously, the current model had improved physiological relevance.
1-s2.0-S2212877817305239-main.pdfddbriar@gmail.com>
Creators: name: Lingling Dai
name: Prerna Bhargava
name: Stanya, Kristopher
name: Alexander, Ryan
name: Yae-Huei Liou
name: Jacobi, David
name: Knudsen, Nelson
name: Hyde, Alexander
name: Gangl, Matthew
name: Sihao Liu
name: Chih-Hao Lee
Publisher: name: Health Research Alliance
Year: 2019
Subjects: subject: 60104 Cell Metabolism
subject: FOS: Biological sciences

description: the study described the role for alternatively activated macrophages regulated by the IL-4/PPAR axis in the protection against lipotoxicity-induced cell dysfunction and metabolic inflammation
Anamenia coriacea Vent., Jard. Malmaison 1803
Creators: name: Callmander, Martin W.
name: Durbin, Olivier D.
name: Lack, Hans-Walter
name: Bungener, Patrick
name: Martin, Pascal
name: Gautier, Laurent
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Mollusca
Solenogastres
Ranunculales
Ranunculaceae
Anamenia
Anamenia coriacea

description: 4. Anamenia coriacea Vent., Jard. Malmaison 1: tab. 22. 1803.
 Lectotypus (designated by Rasmussen, 1979: 27): [SOUTH AFRICA]: Hort. Malmaison, Ventenat s.n. (P-JU n° 10574 [P00667188]!; isolecto-: G [G00406216]!, G-DC [G00144870]!).
 = Anemone vesicatoria (L. f.) Prantl
 Notes. – Rasmussen (1979: 27) designated a lectotype at P-JU for Anemone coriacea now accepted under the name A. vesicatoria. The collection held at P-JU is clearly a duplicate of the one at G, both representing the same gathering from the plant cultivated at Malmaison with Ventenat’s handwriting. Rasmussen (1979) ’s lectotypification on a specimen at P-JU is unfortunate, but has priority. The G specimens (in G and G-DC) are considered here as isolectotypes.
description: Published as part of Callmander, Martin W., Durbin, Olivier D., Lack, Hans-Walter, Bungener, Patrick, Martin, Pascal & Gautier, Laurent, 2017, Etienne-Pierre Ventenat (1757 - 1808) and the gardens of Cels and Empress Joséphine, pp. 87-132 in Candollea 72 (1) on page 97, DOI: 10.15553/c2017v721a8, http://zenodo.org/record/5721919
Open Research Data at Gdańsk University of Technology – from project's assumptions to the integral part of scientific infrastructure
Creators: name: Szuflita-Żurawska, Magdalena
name: Wałek, Anna
name: Szczodruch, Robert
Publisher: name: Zenodo
Year: 2021
Subjects: Research Data Management
research data repository
copyright
Data Management Plan
scientific infrastructure

description: One of the significant challenges for the academic environment-oriented to developing Open Science is Research Data Management (RDM) practices and infrastructures and their popularization among different stakeholders. On the 1st of October 2018, the Bridge of Data project was launched to support data curation and sharing for scientists, especially from Northern Poland. The Bridge of Data project is unique in this part of Central Europe and is the continuum and built upon the previous project called the Bridge of Knowledge that was foremost concentrated on Open Access. The Bridge of Data project includes not only the research data repository (Open Research Data Catalogue) but also a Polish Publishers Copyright Polices database, a Virtual Microscope to present medical images, and a reliable system for publishing journals (based on OJS) and conferences (based on Indico). The project development emphasizes research data and provides technological innovations such as hosting the private, self-hosted computing cloud and storing the data on the Cepch Object Storage. Searching the data is available through open text search due to implementing the NoSQL database – ElasticSearch. Moreover, the project allows researchers to perform Big Data Analysis by Jupiter platform and Apache Spark Engine on the supercomputer Tryton (40.000 cores, 1,5 PFLOPS). Additionally, the Open Science Competency Center was established at Gdansk University of Technology (GUT) Library and provides support and training among researchers from all scientific disciplines on RDM activities such as Data Management Plans or legal issues of sharing research data. This poster will demonstrate the capabilities of the project's components relevant for repository managers, IT staff and developers, librarians, and researchers. It will cover technical as well as substantive aspects of the project. Our poster will include graphical and textual information that will provide the main key points necessary to understand The Bridge of Data project's background and assumptions.
description: The Bridge of Data is co-financed by the European Regional Development Fund within the framework of an Operational Programme Digital Poland for 2014-2020.
A novel ER stress regulator ARL6IP5 induces reticulophagy to ameliorate the prion burden
Creators: name: Kamble, Kajal
name: Kumar, Ujjwal
name: Aahra, Harsh
name: Yadav, Mohit
name: Bhola, Sumnil
name: Gupta, Sarika
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine

description: Prion disease is a fatal and infectious neurodegenerative disorder caused by the trans-conformation conversion of PRNP/PrPC to PRNP/PrPSc. Accumulated PRNP/PrPSc-induced ER stress causes chronic unfolded protein response (UPR) activation, which is one of the fundamental steps in prion disease progression. However, the role of various ER-resident proteins in prion-induced ER stress is elusive. This study demonstrated that ARL6IP5 is compensatory upregulated in response to chronically activated UPR in the cellular prion disease model (RML-ScN2a). Furthermore, overexpression of ARL6IP5 overcomes ER stress by lowering the expression of chronically activated UPR pathway proteins. We discovered that ARL6IP5 induces reticulophagy to reduce the PRNP/PrPSc burden by releasing ER stress. Conversely, the knockdown of ARL6IP5 leads to inefficient macroautophagic/autophagic flux and elevated PRNP/PrPSc burden. Our study also uncovered that ARL6IP5-induced reticulophagy depends on Ca2+-mediated AMPK activation and can induce 3 MA-inhibited autophagic flux. The detailed mechanistic study revealed that ARL6IP5-induced reticulophagy involves interaction with soluble reticulophagy receptor CALCOCO1 and lysosomal marker LAMP1, leading to degradation in lysosomes. Here, we delineate the role of ARL6IP5 as a novel ER stress regulator and reticulophagy inducer that can effectively reduce the misfolded PRNP/PrPSc burden. Our research opens up a new avenue of selective autophagy in prion disease and represents a potential therapeutic target. Abbreviations: ARL6IP5: ADP ribosylation factor-like GTPase 6 interacting protein 5; AMPK: adenosine 5’-monophosphate (AMP)-activated protein kinase; CALCOCO1: calcium binding and coiled-coil domain 1; CQ: chloroquine; DAPI: 4’6-diamino-2-phenylindole; ER: endoplasmic reticulum; ERPHS: reticulophagy/ER-phagy sites; KD: knockdown; KD-CON: knockdown control; LAMP1: lysosomal-associated membrane protein 1; MAP1LC3/LC3, microtubule-associated protein 1 light chain 3; MTOR: mechanistic target of rapamycin kinase; MβCD: methyl beta cyclodextrin; 3 MA: 3-methyladenine; OE: overexpression; OE-CON: empty vector control; PrDs: prion diseases; PRNP/PrPC: cellular prion protein (Kanno blood group); PRNP/PrPSc: infectious scrapie misfolded PRNP; Tm: tunicamycin; UPR: unfolded protein response; UPS: ubiquitin-proteasome system.
Use of Lambda_b Polarimetry in Top Quark Spin-Correlation Functions
Creators: name: Nelson, Charles A.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Due to the absence of hadronization effects and the large top mass, top quark decay will be uniquely sensitive to fundamental electroweak physics at the Tevatron, at the LHC, and at a future linear collider. A complete measurement of the four helicity amplitudes in top decay is possible by the combined use of Lambda_b and W polarimetry in stage-two spin-correlation functions (S2SC). In this paper, the most general Lorentz-invariant decay density matrix is obtained for the decay sequence (t --> W b) where (b --> l nu c) and (W --> l nu), and likewise for the CP-conjugate mode. These density matrices are expressed in terms of b-polarimetry helicity parameters which enable a unique determination of the relative phases among the helicity amplitudes. Thereby, S2SC distributions and single-sided b-W-interference distributions are expressed in terms of these parameters. The four b-polarimetry helicity parameters involving the A(-1,-1/2) amplitude are considered in detail. Lambda_b polarimetry signatures will not be suppressed in top quark analyses when the final neutrino's angles-and-energy variables are used for (b --> l nu c).
description: 34 pages, 1 table, 12 figures, no macros
Zeitvorsorge: Handlungsfelder für die Soziokulturelle Animation
Creators: name: Lindegger, Simon
Publisher: name: Zenodo
Year: 2019

description: Der demografische Wandel und die damit einhergehende Alterung der Gesellschaft wird in der Schweiz auf politischer und medialer Ebene breit diskutiert. Im Fokus steht dabei vorwiegend die finanzielle Alterssicherung in Form der ersten zwei Vorsorgesäulen der AHV und des BVG. Durch eine sich individualisierende und differenzierende Gesellschaft verändern sich Werte und Normen, welche sich auf die Lebensformen der Menschen auswirken. Dieser soziale Wandel bringt auf verschiedenen Ebenen Veränderungen mit sich. Die vorliegende Bachelorarbeit nimmt sich der Thematik des sozialen Wandels in Zusammenhang mit der Lebensgestaltung und Lebensführung im Alter an. Der Umstand von länger aktiven älteren Menschen und von sich wandelnden Werten und Normen bergen grosse Potentiale und neue Herausforderungen. Diesbezüglich wurden auf lokaler Ebene in der Schweiz erste Lösungsansätze lanciert, wie z.B. ein alternatives Vorsorgesystem, welches durch zivilgesellschaftliches Engagement auf soziale und finanzielle Herausforderungen unterstützend wirken soll. Die Idee der Zeitvorsorge besteht darin, dass aktive Menschen im Rentenalter hilfsbedürftige ältere Menschen unterstützen und dafür eine Zeitgutschrift erhalten. Diese könn(t)en bei späterem Bedarf wieder eingelöst werden. Auf welchen Ebenen dieses System der Zeitvorsorge wirkt, welches Potential dieses birgt und was für Herausforderungen sich stellen wird in dieser Arbeit untersucht. Darüber hinaus befasst sich die vorliegende Arbeit damit, inwiefern die Soziokulturelle Animation diese Thematik und das System der Zeitvorsorge mitgestalten soll und kann.
description: + Code Diss LU: hslusa bask 2019 + Fussnote: Bachelorarbeit, Hochschule Luzern - Soziale Arbeit, Ausbildungsgang Soziokultur, 2019 + NL-Code: NLLUHSA201909
Additional file 1 of YAP1 protects against septic liver injury via ferroptosis resistance
Creators: name: Wang, Jin
name: Zhu, Qian
name: Li, Rui
name: Zhang, Jing
name: Ye, Xujun
name: Li, Xinyi
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Supplementary figures.
Electronic structure by X-ray absorption spectroscopy and observation offield induced unusually slowspin relaxation from magnetic properties in pyrochlore Eu$_{2-x}$Fe$_x$Ti$_2$O$_7$
Creators: name: Pal, Arkadeb
name: Ghosh, Surajit
name: Kumar, Shiv
name: Schwier, Eike F.
name: Sawada, Masahiro
name: Shimada, Kenya
name: Gupta, Mukul
name: Phase, D. M.
name: Ghosh, A. K.
name: Chatterjee, Sandip
Publisher: name: arXiv
Year: 2018
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: X-ray absorption spectroscopy (XAS) as well as x-ray magnetic circular dichroism (XMCD) and magnetization of hybrid pyrochlore Eu2-xFexTi2O7 were investigated, where the rare earth Eu (4f) was replaced with transition metal Fe (3d) to introduce competing 4f-3d interactions. It is confirmed that the valence states of Eu and Fe ions are formally trivalent while that of Ti ions are tetravalent (3d0). The analysis yielded that the tetravalent Ti ions occupy octahedral sites with distorted Oh symmetry which is triggered by the presence of vacant 8a anionic site adjacent to TiO6 octahedra. Further study with Fe doping revealed that it essentially reduces the octahedral distortion by introducing anionic disorder (migration of 48f oxygen ions to 8a site). Analysis of O K edge XAS spectra further confirmed the Fe substitution causing the systematic change in the ligand (O2-) coordination of the Ti4+ cations. On the other hand, a new field induced transition (with Fe doping) at low temperature T* (4 K
Ancistrum repens Vent., Descr. Pl. Nouv.
Creators: name: Callmander, Martin W.
name: Durbin, Olivier D.
name: Lack, Hans-Walter
name: Bungener, Patrick
name: Martin, Pascal
name: Gautier, Laurent
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Rosales
Rosaceae
Ancistrum
Ancistrum repens

description: 5. Ancistrum repens Vent., Descr. Pl. Nouv.: tab. 6. 1800.
 Lectotypus (designated here): [PERU]: “individu de pleine terre”, Hort. Cels, Ventenat s.n. (G [G00341457]!).
 = Acaena ovalifolia Ruiz & Pav.
 Notes. – Two specimens are represented in Ventenat’s herbarium that clearly represent two gatherings from Cels’s garden. One collection is from the open ground (“individu de pleine terre”) and the other from the orangery (“individu d’Orangerie”) (G [G00341456]). We designate the first specimen as the lectotype as it better represents the species in the wild, despite the fact that the second specimen from the orangery was very likely the one to have been used for the plate. The specimen in the centre of the sheet n° 14214 in P-JU [P00667169] is from Cels’s garden but no information of its exact provenance is given. It may represent an isolectotype.
description: Published as part of Callmander, Martin W., Durbin, Olivier D., Lack, Hans-Walter, Bungener, Patrick, Martin, Pascal & Gautier, Laurent, 2017, Etienne-Pierre Ventenat (1757 - 1808) and the gardens of Cels and Empress Joséphine, pp. 87-132 in Candollea 72 (1) on page 97, DOI: 10.15553/c2017v721a8, http://zenodo.org/record/5721919
ATP6V1D drives hepatocellular carcinoma stemness and progression via both lysosome acidification-dependent and -independent mechanisms
Creators: name: Xu, Zhijie
name: Liu, Ruiyang
name: Ke, Haoying
name: Xu, Fuyuan
name: Yang, Pengfei
name: Zhang, Weiyu
name: Zhan, Yi
name: Zhao, Zhiju
name: Xiao, Fei
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Metabolic reprogramming is pivotal in cancer stem cell (CSC) self-renewal. However, the intricate regulatory mechanisms governing the crosstalk between metabolic reprogramming and liver CSCs remain elusive. Here, using a metabolic CRISPR-Cas9 knockout screen, we identify ATP6V1D, a subunit of the vacuolar-type H+-translocating ATPase (V-ATPase), as a key metabolic regulator of hepatocellular carcinoma (HCC) stemness. Elevated ATP6V1D expression correlates with poor clinical outcomes in HCC patients. ATP6V1D knockdown inhibits HCC stemness and malignant progression both in vitro and in vivo. Mechanistically, ATP6V1D enhances HCC stemness and progression by maintaining macroautophagic/autophagic flux. Specifically, ATP6V1D not only promotes lysosomal acidification, but also enhances the interaction between CHMP4B and IST1 to foster ESCRT-III complex assembly, thereby facilitating autophagosome-lysosome fusion to maintain autophagic flux. Moreover, silencing CHMP4B or IST1 attenuates HCC stemness and progression. Notably, low-dose bafilomycin A1 targeting the V-ATPase complex shows promise as a potential therapeutic strategy for HCC. In conclusion, our study highlights the critical role of ATP6V1D in driving HCC stemness and progression via the autophagy-lysosomal pathway, providing novel therapeutic targets and approaches for HCC treatment. Abbreviations: 3-MA: 3-methyladenine; ANT: adjacent normal liver tissues; ATP6V1D: ATPase H+ transporting V1 subunit D; BafA1: bafilomycin A1; CHMP: charged multivesicular body protein; co-IP: co-immunoprecipitation; CSC: cancer stem cell; ESCRT: endosomal sorting complex required for transport; HCC: hepatocellular carcinoma; IF: immunofluorescence; IHC: immunohistochemical; LCSCs: liver cancer stem cells; qRT-PCR: quantitative real time PCR; V-ATPase: vacuolar-type H+- translocating ATPase; WB: western blot.
Retipenna grahami
Creators: name: Wu, Jingyu
name: Liu, Xingyue
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Neuroptera
Chrysopidae
Retipenna
Retipenna grahami

description: [48] Retipenna grahami (Banks, 1942 [1940])
(Fig. 87)
Chrysopa grahami Banks, 1942: 189. Type locality: China (Sichuan, Washan). Holotype in USNM.
Chrysopa chione Banks, 1942: 189. Type locality: China (Sichuan, Beh Luh Din [Bailuding] and Omei). Holotype in USNM. syn. nov.
Retipenna grahami: Brooks & Barnard, 1990: 265.
Retipenna chione: Brooks & Barnard, 1990: 265.
Diagnosis. Body length 13 mm, forewing length 15–20 mm, hindwing length 16–18 mm. Head without spots. Antennae yellow. Frons, clypeus and gena not marked. Maxillary and labial palpi brownish yellow. Thorax not marked. Legs with dense setae. Pretarsal claws brown, with basal dilation. Forewing with dense setae, inner gradate series brown; costal area with 30 crossveins; pterostigma pale brown; 16 radial crossveins and 8–9 psm-psc crossveins present; m1 smaller than m2; im ovoid; c1 smaller than c2; dcc opened; CuP brown, with brown shadings; inner gradate series with 12 brown crossveins, outer gradate series with 10 crossveins. Hindwing narrow; 18 radial crossveins and 9 psm-psc crossveins present; inner gradate series with 10 crossveins, outer gradate series with 9 crossveins.
Distribution. China (Sichuan).
Remarks. Banks (1942) established R. grahami and R. chione, which were both collected from Sichuan, and noted that they are very similar except for a difference in body size. We do not agree that such a small body size difference can be used as an identification character and thus treat R. chione as a synonym of R. grahami. This species is similar to R. parvula in brown inner gradates and brown shading on CuP of forewing. Breitkreuz (2018) offered habitus photo of this species, but genital characteristics are unknown.
description: Published as part of Wu, Jingyu & Liu, Xingyue, 2024, Systematics of the green lacewing tribe Ankylopterygini Navás, 1910 (Neuroptera: Chrysopidae: Chrysopinae) from China, pp. 1-169 in Zootaxa 5540 (1) on page 108, DOI: 10.11646/zootaxa.5540.1.1, http://zenodo.org/record/14240496
Disassembly line design with multi-manned workstations: a novel heuristic optimisation approach
Creators: name: Cevikcan, Emre
name: Aslan, Dicle
name: Yeni, Fatma Betul
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: As the first and the most time consuming step of product recovery, disassembly is described as the systematic separation of constituent parts from end-of-life products through a series of operations. In this context, designing and balancing disassembly lines are critical in terms of the efficiency of product recovery. Recent research on disassembly line balancing (DLB) has focused on classical stations where only one worker is allocated. However, such a line results in larger space requirement and longer disassembly lead time. In this paper, disassembly line balancing problem (DLBP) with multi-manned stations is introduced to the relevant literature as a solution to overcome these disadvantages. A mixed integer linear programming (MILP) model and two novel framework heuristic algorithms are developed to minimise the number of workers and workstations. MILP model has been applied to a dishwasher disassembly system. The application results indicate the superiority of establishing multi-manned stations over classical disassembly system design with single-worker stations with shorter disassembly lead time (80.9%) and line length (60.2%). Moreover, the proposed heuristics have been compared on newly generated test problems (instances) for DLBP. The results validate that the heuristics provide acceptable solutions in a reasonable amount of time even for large-sized problems.
Two-loop QCD corrections to massless quark-gluon scattering
Creators: name: Anastasiou, C.
name: Glover, E. W. N.
name: Oleari, C.
name: Tejeda-Yeomans, M. E.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present the O(alphas^4) virtual QCD corrections to the scattering process of massless quark qqbar -> gg due to the interference of tree and two-loop amplitudes and to the self-interference of one-loop amplitudes. We work in conventional dimensional regularisation and our results are renormalised in the MSbar scheme. The structure of the infrared divergences agrees with that predicted by Catani while expressions for the finite remainder are given for the qqbar -> gg and the qg -> qg (gqbar -> gqbar) scattering processes in terms of logarithms and polylogarithms that are real in the physical region. These results, together with those previously obtained for quark-quark scattering, are important ingredients in the next-to-next-to-leading order contribution to inclusive jet production at hadron colliders.
description: 32 pages, LaTeX, JHEP class, typo in Eq.4.6 fixed, typo in Eq 3.2 fixed
MOESM1 of High CTHRC1 expression may be closely associated with angiogenesis and indicates poor prognosis in lung adenocarcinoma patients
Creators: name: Chen, Yangshan
name: Sun, Yu
name: Cui, Yongmei
name: Lei, Yiyan
name: Jiang, Neng
name: Jiang, Wenting
name: Wang, Han
name: Chen, Lili
name: Luo, Jiping
name: Chen, Yanyang
name: Tang, Kejing
name: Zhou, Chengzhi
name: Ke, Zunfu
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 1: Figure S1. Representative immunochemistry stains for CTHRC1, VEGF and CD34. Representative image of a 0, b 0–10%, c 11–50%, d 51–75% and e > 75% of cancer cells stained for CTHRC1 IHC staining and f–j for five cancer cells stained categories for VEGF IHC staining in LUAD tissue samples. k–o IHC staining of different MVDs in LUAD tissue arrays. Scale bar: 50 μm. CTHRC1, collagen triple helix repeat containing 1; VEGF, vascular endothelial growth factor; MVD, microvessel density; IHC, immunochemistry; LUAD, lung adenocarcinoma. Figure S2. Advanced clinical stage determined the worse prognosis in LUAD. Kaplan-Meier survival curves for OS and PFS according to a clinical stage, b T, c N, and d M classification. Vertical tick marks censored subjects. Bonferroni correction was used to adjust the statistical significance level (Table S1–3). CTHRC1, collagen triple helix repeat containing 1; VEGF, vascular endothelial growth factor; MVD, microvessel density; LUAD, lung adenocarcinoma; OS, overall survival; PFS, progression-free survival. Figure S3. No significant difference was observed between CTHRC1-High group and CTHRC1-Low group in a, b T 3–4, c, d N 1–3 and e, f M1 subgroups.