cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Greenhouse gas emissions from a Cu-contaminated soil remediated by in situ stabilization and phytomanaged by a mixed stand of poplar, willows, and false indigo-bush
Creators: name: M. Šimek
name: D. Elhottová
name: M. Mench
name: L. Giagnoni
name: P. Nannipieri
name: G. Renella
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Plant Biology
subject: Computational Biology

description: Phytomanagement of trace element-contaminated soils can reduce soil toxicity and restore soil ecological functions, including the soil gas exchange with the atmosphere. We studied the emission rate of the greenhouse gases (GHGs) CO2, CH4, and N2O; the potential CH4 oxidation; denitrification enzyme activity (DEA), and glucose mineralization of a Cu-contaminated soil amended with dolomitic limestone and compost, alone or in combination, after a 2-year phytomanagement with a mixed stand of Populus nigra, Salix viminalis, S. caprea, and Amorpha fruticosa. Soil microbial biomass and microbial community composition after analysis of the phospholipid fatty acids (PLFA) profile were determined. Phytomanagement significantly reduced Cu availability and soil toxicity, increased soil microbial biomass and glucose mineralization capacity, changed the composition of soil microbial communities, and increased the CO2 and N2O emission rates and DEA. Despite such increases, microbial communities were evolving toward less GHG emission per unit of microbial biomass than in untreated soils. Overall, the aided phytostabilization option would allow methanotrophic populations to establish in the remediated soils due to decreased soil toxicity and increased nutrient availability.
Genome-wide DNA Methylation Associations with Spontaneous Preterm Birth in US Blacks: Findings in Maternal and Cord Blood Samples
Creators: name: Xiumei Hong
name: Sherwood, Ben
name: Ladd-Acosta, Christine
name: Shouneng Peng
name: Hongkai Ji
name: Hao, Ke
name: Burd, Irina
name: Bartell, Tami R
name: Guoying Wang
name: Tsai, Hui-Ju
name: Liu, Xin
name: Yuelong Ji
name: Anastacia Wahl
name: Caruso, Deanna
name: Lee-Parritz, Aviva
name: Zuckerman, Barry
name: Xiaobin Wang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Preterm birth (PTB) affects one in six U.S. Black babies. Epigenetics is believed to play a role in PTB; however, only a limited number of epigenetic studies of PTB have been reported, most of which have focused on cord blood DNA methylation (DNAm) and/or were conducted in white populations. Here we conducted, by far, the largest epigenome-wide DNAm analysis in 300 Black women who delivered early spontaneous preterm (sPTB, n = 150) or full-term babies (n = 150) and replicated the findings in an independent set of Black mother-newborn pairs from the Boston Birth Cohort. DNAm in maternal blood and/or cord blood was measured using the Illumina HumanMethylation 450K BeadChip. We identified 45 DNAm loci in maternal blood associated with early sPTB, with a false discovery rate (FDR) <5%. Replication analyses confirmed sPTB associations for cg03915055 and cg06804705, located in the promoter regions of the CYTIP and LINC00114 genes, respectively. Both loci had comparable associations with early sPTB and early mPTB, but attenuated associations with late sPTB. These associations could not be explained by cell composition, gestational complications, and/or nearby maternal genetic variants. Analyses in the newborns of the 110 Black women showed that cord blood methylation levels at both loci had no associations with PTB. The findings from this study underscore the role of maternal DNAm in PTB risk, and provide a set of maternal loci that may serve as biomarkers for PTB. Longitudinal studies are needed to clarify temporal relationships between maternal DNAm and PTB risk.
Carnet nº 2, commencé à Vienne (p. 93)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: created: 15-10-1928
Genome-wide DNA methylation associations with spontaneous preterm birth in US blacks: findings in maternal and cord blood samples
Creators: name: Xiumei Hong
name: Sherwood, Ben
name: Ladd-Acosta, Christine
name: Shouneng Peng
name: Hongkai Ji
name: Hao, Ke
name: Burd, Irina
name: Bartell, Tami R
name: Guoying Wang
name: Tsai, Hui-Ju
name: Liu, Xin
name: Yuelong Ji
name: Anastacia Wahl
name: Caruso, Deanna
name: Lee-Parritz, Aviva
name: Zuckerman, Barry
name: Xiaobin Wang
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Preterm birth (PTB) affects one in six Black babies in the United States. Epigenetics is believed to play a role in PTB; however, only a limited number of epigenetic studies of PTB have been reported, most of which have focused on cord blood DNA methylation (DNAm) and/or were conducted in white populations. Here we conducted, by far, the largest epigenome-wide DNAm analysis in 300 Black women who delivered early spontaneous preterm (sPTB, n = 150) or full-term babies (n = 150) and replicated the findings in an independent set of Black mother-newborn pairs from the Boston Birth Cohort. DNAm in maternal blood and/or cord blood was measured using the Illumina HumanMethylation450 BeadChip. We identified 45 DNAm loci in maternal blood associated with early sPTB, with a false discovery rate (FDR) <5%. Replication analyses confirmed sPTB associations for cg03915055 and cg06804705, located in the promoter regions of the CYTIP and LINC00114 genes, respectively. Both loci had comparable associations with early sPTB and early medically-indicated PTB, but attenuated associations with late sPTB. These associations could not be explained by cell composition, gestational complications, and/or nearby maternal genetic variants. Analyses in the newborns of the 110 Black women showed that cord blood methylation levels at both loci had no associations with PTB. The findings from this study underscore the role of maternal DNAm in PTB risk, and provide a set of maternal loci that may serve as biomarkers for PTB. Longitudinal studies are needed to clarify temporal relationships between maternal DNAm and PTB risk.
On the guiding principles for understanding of geometrical structures of the CaMn4O5 cluster in oxygen-evolving complex of photosystem II. Proposal of estimation formula of structural deformations via the Jahn–Teller effects
Creators: name: K. Yamaguchi
name: M. Shoji
name: H. Isobe
name: S. Yamanaka
name: Y. Umena
name: K. Kawakami
name: N. Kamiya
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Inorganic Chemistry
subject: Computational Biology

description: Atmospheric oxygenation and evolution of aerobic life on our earth are a result of water oxidation by oxygenic photosynthesis in photosystem II (PSII) of plants, algae and cyanobacteria. The water oxidation in the oxygen-evolving complex (OEC) in PSII is expected to proceed through five oxidation states, known as the Si (i = 0, 1, 2, 3 and 4) states in the Kok cycle, with the S1 being the most stable state in the dark. The OEC in PSII involves the active catalytic site made of four Mn ions and one Ca ion, namely the CaMn4O5 cluster. Past decades, molecular structures of the CaMn4O5 cluster in OEC in PSII have been investigated by the extended X-ray absorption fine structure (EXAFS). The magneto-structural correlations were extensively investigated by electron paramagnetic resonance (EPR) spectroscopy. Recently, Kamiya and Shen groups made great breakthrough for determination of the S1 structure of OEC of PSII by the X-ray diffraction (XRD) and X-ray free-electron laser (XFEL) experiments, providing structural foundations that are crucial for theoretical investigations of the CaMn4O5 cluster. Large-scale quantum mechanics/molecular mechanics calculations starting from the XRD structures elucidated geometrical, electronic and spin structures of the CaMn4O5 cluster, indicating an important role of the Jahn–Teller (JT) effect of Mn(III) ions. This paper presents theoretical formulas for estimation of the JT deformations of the CaMn4O5 cluster in OEC of PSII. Scope and applicability of the formulas are examined in relation to several different structures of the CaMn4O5 cluster proposed by XRD, XFEL, EXAFS and other experiments. Implications of the computational results are discussed for further refinements of geometrical parameters of the CaMn4O5 cluster.
Greenhouse gas emissions from a Cu-contaminated soil remediated by in situ stabilization and phytomanaged by a mixed stand of poplar, willows and false indigo-bush
Creators: name: M. Šimek
name: D. Elhottová
name: M. Mench
name: L. Giagnoni
name: P. Nannipieri
name: G. Renella
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Computational Biology

description: Phytomanagement of trace element-contaminated soils can reduce the soil toxicity and restore the soil ecological functions, including the soil gas exchange with the atmosphere. We studied the emission rate of the greenhouse gases (GHG) CO2, CH4 and N2O, and the potential CH4 oxidation, denitrification activity (DEA) and glucose mineralization of a Cu-contaminated soil amended with dolomitic limestone and compost, alone or in combination, after a 2 year-phytomanagement with a mixed stand of Populus nigra, Salix viminalis, S. caprea and Amorpha fruticosa. Soil microbial biomass and microbial community composition after analysis of the phospholipid fatty acids profile (PLFA) were determined. Phytomanagement significantly reduced Cu availability and soil toxicity, increased soil microbial biomass and glucose mineralization capacity, changed the composition of soil microbial communities, and increased the CO2 and N2O emission rates and DEA. Despite such increases, microbial communities were evolving towards less GHG emission per unit of microbial biomass than in untreated soils. In overall, the aided phytostabilization option would allow methanotrophic populations to establish in the remediated soils due to decreased soil toxicity and increased nutrient availability.
Genome-wide DNA methylation associations with spontaneous preterm birth in US blacks: findings in maternal and cord blood samples
Creators: name: Xiumei Hong
name: Sherwood, Ben
name: Ladd-Acosta, Christine
name: Shouneng Peng
name: Hongkai Ji
name: Hao, Ke
name: Burd, Irina
name: Bartell, Tami R
name: Guoying Wang
name: Tsai, Hui-Ju
name: Liu, Xin
name: Yuelong Ji
name: Anastacia Wahl
name: Caruso, Deanna
name: Lee-Parritz, Aviva
name: Zuckerman, Barry
name: Xiaobin Wang
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Preterm birth (PTB) affects one in six Black babies in the United States. Epigenetics is believed to play a role in PTB; however, only a limited number of epigenetic studies of PTB have been reported, most of which have focused on cord blood DNA methylation (DNAm) and/or were conducted in white populations. Here we conducted, by far, the largest epigenome-wide DNAm analysis in 300 Black women who delivered early spontaneous preterm (sPTB, n = 150) or full-term babies (n = 150) and replicated the findings in an independent set of Black mother-newborn pairs from the Boston Birth Cohort. DNAm in maternal blood and/or cord blood was measured using the Illumina HumanMethylation450 BeadChip. We identified 45 DNAm loci in maternal blood associated with early sPTB, with a false discovery rate (FDR) <5%. Replication analyses confirmed sPTB associations for cg03915055 and cg06804705, located in the promoter regions of the CYTIP and LINC00114 genes, respectively. Both loci had comparable associations with early sPTB and early medically-indicated PTB, but attenuated associations with late sPTB. These associations could not be explained by cell composition, gestational complications, and/or nearby maternal genetic variants. Analyses in the newborns of the 110 Black women showed that cord blood methylation levels at both loci had no associations with PTB. The findings from this study underscore the role of maternal DNAm in PTB risk, and provide a set of maternal loci that may serve as biomarkers for PTB. Longitudinal studies are needed to clarify temporal relationships between maternal DNAm and PTB risk.
THE LIMITATION OF PENAL LAW IN THE EXERCISE OF BUSINESS CITIZENSHIP
Creators: name: RICARDO ALVES BENTO
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: The Criminal Law needs to be a real implement to achieve the preservation of the criminal goods in the Democratic State ol Law, acting as the necessary tool for the society. This way, society should constantly judge the criminal preservation benefit which are intolerable, to reach the perfect understanding between the citizens. The criminal laes due legislative process should be observed for the appropriated answer to the society´s wishes, always with the observation of the criminalization delegation emitted by the Federal Constituion of 1988, that completed 18(eighteen) years of its promulgation, where are related the criminal references that the State as a legitimed detainer of the right to punish should act.This point of view, Criminal Law has the duty to be accommodated to other ways to reach its ethics behavior. The Criminal Law´s Ethics will be reached, for example, by offering to the enterpriser criminal opportunity to help the society, keeping the social skin even business relations. Questions may appear in this application: Criminal Law´s Ethics will only be acchieved when the its legislator observes the real incumbence of the law group, which is criminal goods preservation and occasional punishment application in front of positive case. Will we continue using the Criminal Law as one implement of prima ratio to deal with the behaviors or we will using Criminal Law only as ultima ration application. This article has the purpose of examination of Criminal Law´s ethics and its properties, to reach corporative citizenship.
Open Science in the 21st Century: Increasing scientists’ visibility and improving research efficiency
Creators: name: Bik, Holly
Publisher: name: figshare
Year: 2017
Subjects: subject: Computational Biology
subject: 60408 Genomics
subject: FOS: Biological sciences

description: A white paper submitted for consideration and discussion at the workshop "Imagining Tomorrow's University" (March 8-9, 2017 at the Big10 conference center in Rosemont, IL).
http://www.ncsa.illinois.edu/Conferences/ImagineU/
Expansion potential of invasive tree plants in ecoregions under climate change scenarios: an assessment of 54 species at a global scale
Creators: name: Wang, Chun-Jing
name: Wan, Ji-Zhong
name: Zhang, Zhi-Xiang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences

description: Climate change may increase expansion risk of invasive tree plants (ITPs) worldwide. Ecoregions are the power conservation tool for the management of ITPs. However, few studies have investigated the relationship between ITP expansion and ecoregions at the global scale under climate change scenarios. Here, we provided a method to evaluate the expansion potential of 54 representative ITPs in ecoregions specifically under influences of the changing climate at the global scale. We found that climate change due to increasing greenhouse gas (GHG) concentration plays a positive role on the expansion of ITPs. We determined two of the most important ecoregion hotspots of ITP expansion potential, such as New Zealand and South Africa. In addition, ITPs were likely to have a large potential to expand in ecoregions of five different biomes, like temperate broadleaf and mixed forests. The potential expansion of ITPs would increase obviously in ecoregions of Boreal Forests/Taiga and Tundra. More importantly, the ecoregions of high elevation belonging to Tropical and Subtropical Coniferous Forests were expected to experience the higher expansion risk in the low GHG concentration scenario. Given our estimates of ITP expansion for ecoregions, management for the prevention and control for ITPs is urgent at the global scale.
Effects of different compatilizers on mechanical, crystallization and thermal properties of polypropylene/magensium oxysulfate whisker composites
Creators: name: Dang, Li
name: Xueying Nai
name: Donghai Zhu
name: Naicai Xu
name: Yaping Dong
name: Li, Wu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Two kinds of compatilizers, maleic anhydride grafted polyolefin elastomer (POE-g-MAH) and maleic anhydride grafted polypropylene (PP-g-MAH), were incorporated into a polypropylene/magnesium oxysulfate whisker (PP/MOSw) composite. Scanning electron microscopy pictures presented a clear interface between MOSw and the PP matrix in the PP/MOSw composite, while vague interfaces appeared in the PP/iPOE-g-MAH/5MOSw and PP/iPP-g-MAH/5MOSw composites. Dynamic mechanical thermal analysis results indicated that PP-g-MAH was highly compatible with the PP matrix while POE-g-MAH was not. Impact strength results showed that POE-g-MAH had a superior toughening effect on PP/MOSw composites, since the proper interfacial interaction and appearance of β-crystal PP. However, incorporating PP-g-MAH seemed to be conducive to increasing strength and modulus (both for tensile and flexural tests), as evidenced by the greatly raised interfacial adhesion between the PP matrix and MOSw. Quantitative characterization carried out by Turcsányi equation for ternary composites also confirmed that PP-g-MAH efficiently enhanced interfacial interaction, by the proof of higher B values. Therefore, the thermal stability of PP-g-MAH treated composites was far superior to that of PP/iPOE-g-MAH/5MOSw composites. Differential scanning calorimetery and polarized light microscopy results showed that POE-g-MAH promoted PP nucleation, with effects further enhanced with the presence of PP-g-MAH.
Synthesis, characterization and in vitro cytotoxicity of platinum(II) complexes of selenones [Pt(selenone)2Cl2]
Creators: name: Altoum, Ali Osman S.
name: Alhoshani, Ali
name: Alhosaini, Khalid
name: Altaf, Muhammad
name: Ahmad, Saeed
name: Saheed A. Popoola
name: Abdulaziz A. Al-Saadi
name: Sulaiman, Adam A.
name: Anvarhusein A. Isab
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Platinum(II) complexes with various selenones (L) having the general formula [PtL2Cl2] were prepared and characterized by elemental analysis and, IR and NMR (1H, 13C, and 77Se) spectroscopies. A decrease in the IR frequency of the >C=Se mode and an upfield shift in 13C NMR for the >C=Se resonance of selenones are consistent with their selenium coordination to platinum(II). The NMR data show that the complexes are stable in solution and do not undergo equilibration at 297 K. The geometrical structures of the complexes were predicted theoretically (with DFT method) using Gaussian09 program. DFT calculations predicted that the trans configurations were up to 1.7 kcal/mol more stable than the cis forms in gas phase, while in solution form the cis isomers were predicted to be more stable. The UV–vis spectra of the two complexes, 6 and 7 were also recorded at room temperature for 24 h and it was observed that the complexes were stable and did not undergo decomposition. The in vitro antitumor properties of the complexes as well as of cisplatin were evaluated on two human cancer cell lines, HeLa (cervical cancer cells) and MCF7 (breast cancer cells) using MTT assay. The results indicated that the prepared complexes exerted significant inhibition on the selected cancer cells.
Barcoding gap, but no support for cryptic speciation in the earthworm Aporrectodea longa (Clitellata: Lumbricidae)
Creators: name: Martinsson, Svante
name: Rhodén, Caroline
name: Erséus, Christer
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: DNA-barcoding, using the mitochondrial marker COI, has been found successful for the identification of specimens in many animal groups, but may not be suited for species discovery and delimitation if used alone. In this study, we investigate whether two observed COI haplogroups in the earthworm Aporrectodea longa correspond to two cryptic species or if the variation is intraspecific. This is done by complementing COI with two nuclear markers, ITS2 and Histone 3. The variation is studied using distance methods, parsimony networks and Bayesian coalescent trees, and the statistical distinctness of the groups is tested on gene trees using the genealogical sorting index, Rosenberg’s PAB and Rodrigo et al.’s P(RD). We also applied multilocus species delimitation based on the multispecies coalescence model. The two haplogroups were found in COI, and all tests except P(RD) found them to be significantly distinct. However, in ITS2, the same groups were not recovered in any analyses or tests. H3 was invariable in A. longa, and was, therefore, included only in the multilocus analysis, which preferred a model treating A. longa as one species over a model splitting it into two. We also compared two measurements of size, body length, and no. of segments between the groups. No difference in body length was found, and although a significant difference in no. of segments was noted the haplogroup with the lower mean showed both the highest and the lowest value. When combined, these results led us to the conclusion that there is no support for the separation of A. longa into two cryptic species. This study again highlights the importance of complementing mitochondrial barcodes with more data when establishing species boundaries.
Additional file 1: of The proto-oncogene Mer tyrosine kinase is a novel therapeutic target in mantle cell lymphoma
Creators: name: Shi, Cunzhen
name: Li, Xiangqun
name: Wang, Xiaogan
name: Ding, Ning
name: Ping, Lingyan
name: Shi, Yunfei
name: Mi, Lan
name: Lai, Yumei
name: Song, Yuqin
name: Zhu, Jun
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Table S1. Baseline characteristics of MCL patients receiving R-CHOP like regimens and their correlations with MerTK. Table S2. Information of antibodies applied in immunohistochemistry and western blot assays. Table S3. Combination index values of UNC2250 and Vincristine or Doxorubicin in Z-138 and Mino cells. (DOCX 28Â kb)
Clinical use of PI3K inhibitors in B-cell lymphoid malignancies: today and tomorrow
Creators: name: I. B. Greenwell
name: C. R. Flowers
name: K. A. Blum
name: J. B. Cohen
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Introduction: PI3K inhibitors are an important new therapeutic option for the treatment of relapsed and refractory B-cell lymphoid malignancies. Idelalisib is a PI3Kδ inhibitor that has been approved for the treatment of lymphoma and chronic lymphocytic leukemia in the relapsed/refractory setting, and several other PI3K inhibitors are being developed targeting other isoforms of the PI3K enzyme, which results in distinct toxicities and variable efficacy in the clinical setting. Areas covered: We provide a general overview of PI3K inhibitors, recommended applications, and the mechanism and management of toxicities. We further review trials, ongoing and completed, leading to the approval of idelalisib as well other PI3K inhibitors currently in development. Articles were obtained from PubMed, and abstracts were searched for the past 5 years from the websites for ASCO, ASH, EHA, and ICML/Lugano. Expert commentary: PI3K inhibitors provide an important and powerful pharmacologic tool in the armamentarium against hematologic malignancies, especially for relapsed/refractory B-cell lymphoid malignancies. Unique toxicities are associated with inhibition of different isoforms of the PI3K enzyme, as demonstrated with the infectious and autoimmune toxicities associated with the PI3Kδ inhibitor, idelalisib. Due to these unique toxicities, PI3K inhibitors should only be used in formally approved combinations and settings.
Desafíos de la comunicación científica y académica-2.docx
Creators: name: Cañedo-Andalia, Rubén
Publisher: name: figshare
Year: 2017
Subjects: subject: 80706 Librarianship
subject: FOS: Media and communications
subject: 80610 Information Systems Organisation
subject: FOS: Computer and information sciences

description: Comment
Doctoral thesis recital (percussion)
Creators: name: Walsh, Jordan
Publisher: name: The University of Texas at Austin
Year: 2020
Subjects: Percussion ensembles
Piano with percussion ensemble

description: Fixtures in the fold : (2017) / Douglas Hertz -- Taxidermy : (2012) / Caroline Shaw -- Intact : (2015) / Zach Albrecht -- An absolute insufficiency of electricity : (2017) / Jacob Rogers -- Mallett quartet : (2009) / Steve Reich.
Additional file 2: of The proto-oncogene Mer tyrosine kinase is a novel therapeutic target in mantle cell lymphoma
Creators: name: Shi, Cunzhen
name: Li, Xiangqun
name: Wang, Xiaogan
name: Ding, Ning
name: Ping, Lingyan
name: Shi, Yunfei
name: Mi, Lan
name: Lai, Yumei
name: Song, Yuqin
name: Zhu, Jun
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Supplementary Methods: Confocal immunofluorescence assays; RNA extraction, reverse transcription and Real-Time PCR. (DOCX 2252Â kb)
Additional file 3: of The proto-oncogene Mer tyrosine kinase is a novel therapeutic target in mantle cell lymphoma
Creators: name: Shi, Cunzhen
name: Li, Xiangqun
name: Wang, Xiaogan
name: Ding, Ning
name: Ping, Lingyan
name: Shi, Yunfei
name: Mi, Lan
name: Lai, Yumei
name: Song, Yuqin
name: Zhu, Jun
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Virology

description: Figure S1. MerTK knockdown mediated by shMerTK 4 suppressed downstream signaling pathways and proliferation in MCL cells. Figure S2. MerTK inhibition by either shRNA or treatment with UNC2250 suppressed migration of MCL cells. Figure S3. The effects of UNC2250 on proliferation and apoptosis of MCL cells. Figure S4. Representative flow cytometry profiles for apoptosis assays in Z-138, Mino and JVM-2 cells. Figure S5. Representative flow cytometry profiles for cell cycle analysis in Z-138, Mino and JVM-2 cells. Figure S6. Proliferation of Z-138 and Mino cells was inhibited with increasing concentrations of vincristine or doxorubicin. Figure S7. Expression of microRNA-126, microRNA-335 and Gas6 in MCL cells. (DOCX 15Â kb)
Inducing pollution prevention adoption: effectiveness of the 33/50 voluntary environmental program
Creators: name: Bi, Xiang
name: Khanna, Madhu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Pharmacology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: The Environmental Protection Agency has encouraged voluntary efforts at pollution prevention by facilities through participation in voluntary environmental programs (VEPs) such as the 33/50 program to reduce toxic releases. This paper examines the effectiveness of the 33/50 program in the adoption of pollution prevention practices and disentangles the effect of adoption from that of program participation on releases of 33/50 chemicals. Using facility-specific panel data and controlling for the endogeneity of program participation and pollution prevention adoption, we find that program participants were 38% more likely to adopt pollution prevention practices than non-participants. Program participants who adopted pollution prevention practices reduced their 33/50 releases by 52% compared to facilities that neither participated nor adopted pollution prevention. This indicates that VEPs that emphasize pollution prevention can play a complementary role in reducing toxic releases.
Unique Identifiers: Current Landscape and Future Trends
Creators: name: Leggott, Mark
name: Shearer, Kathleen
name: Ridsdale, Chantel
name: Barsky, Eugene
name: Baker, David
Publisher: name: Zenodo
Year: 2016
Subjects: subject: Digital Object Identifiers
subject: Persistent Identifiers
subject: ORCID Identifiers
subject: Institutional Identifiers
subject: Equipment Identifiers
subject: http://dictionary.casrai.org/Persistent_identifier
subject: http://dictionary.casrai.org/Digital_Object_Identifier
subject: http://dictionary.casrai.org/Research_data_management

description: This paper is the first in a series of best practice documents produced by Research Data Canada that will be combined with other outputs from RDC and other organizations to provide a foundation and roadmap leading towards a comprehensive national framework for research data management in Canada. It is intended to provide an overview of the current landscape of research PIDs, and will provide insights into their role in developing a more cohesive virtual research environment, supporting the preservation, discoverability, and reuse of research information. The aims of this paper are to: provide all readers, regardless of expertise, with a better understanding of the role of unique identifiers; identify best practices in the international research data management community that facilitate the development of robust and sustainable systems for identifying and linking research outputs; describe the current state of adoption of PIDs in Canada and internationally; offer recommendations to the Canadian research community about the adoption of PIDs in various contexts.
description: This document was produced by the Best Practices: PIDs Working Group of the Standards and Interoperability Committee of Research Data Canada.
Spatial loess distribution in the eastern Carpathian Basin: a novel approach based on geoscientific maps and data
Creators: name: Lindner, Heiko
name: Lehmkuhl, Frank
name: Zeeden, Christian
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: Geo- and palaeoecological studies in the Carpathian Basin require a detailed knowledge of the distribution of aeolian sediments. Existing maps are not detailed enough and erroneous as a result of the basic input data and scale used. Here we present a map showing the detailed distribution of loess sediments in the Carpathian Basin at the border of Hungary and Romania using a Geographic Information System and the vectorized, statistically analysed geological map of Hungary (scale 1:300,000) and the Romanian pedological map (scale 1:500,000). Both, the Hungarian and the Romanian data sets were combined and transferred into a common loess sediment classification system resulting in a seamless cross-border map showing the loess distribution in the Carpathian Basin at a scale of about 1:500,000.
title: Mail transféré à Olivier Charmeil et Catherine Lassale - Pièce jointe 2
Creators: name: Leibowitch, Jacques
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Pièces jointes : Jacques Leibowitch, et al., "Short cycles of antiretroviral drugs provide intermittent yet effective therapy: a pilot study in 48 patients with chronic HIV infection", extrait de The Faseb Journal, 26 janvier 2010 et Béatrice Vuaille, "Les résultats encourageants d'une équipe française : VIH, le concept de traitement intermittent", extrait de Informations médicales.
description: Source: http://www.calames.abes.fr/pub/ms/Calames-20193111134069917
description: created: start=2011-02-10;end=2011-06-14
title: : Censo de frutos y manufacturas de España dir. Marcos Marin por el oficial D. Juan Polo y Catalina
Creators: name: Polo y Catalina, Juan
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Auteur pas à la B.N.

Reliure espagnole 1799
description: Source: Bibliothèque patrimoniale Villon (Rouen), Fonds Leber, Mt T 453 Rés
Introdução
Creators: name: De Sá Basílio Lins, Silvia Maria
name: Santana, Rosimere Ferreira
name: De Lima Bezerra, Polyana Caroline
name: Prado, Patricia Rezende Do
name: Cardoso, Rosane Barreto
name: Valérya Maria De Almeida França De Souza
Publisher: name: OSF Registries
Year: 2022

description: Averiguar sobre os estudos existentes a respeito do Diagnóstico de Enfermagem Síndrome do Idoso Frágil
When the end matters: influence of gender cues during agreement computation in bilinguals
Creators: name: Sendy Caffarra
name: Barber, Horacio
name: Molinaro, Nicola
name: Carreiras, Manuel
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The present event-related potential (ERP) study was aimed at testing whether form-function mappings can differently affect sentence comprehension in early bilinguals with a range of linguistic profiles. Basque–Spanish and Spanish–Basque early bilinguals were presented with Spanish sentences with article-noun gender agreement violations. The gender of the target noun could be retrieved based on the word-form (i.e. transparent nouns) or only on a lexical representation (i.e. opaque nouns). While Basque-dominant bilinguals showed an impact of gender-to-ending consistency on agreement computation, Spanish-dominant bilinguals’ agreement processing was not affected by form-function mappings. A multiple regression analysis on early ERP responses from all participants showed that the more Spanish was produced on a daily basis, the easier the detection of gender violation for opaque nouns. The present results suggest that the strength of the lexical representation of gender is not fixed and can change depending on the linguistic habits of early bilinguals.
Surface forms trump underlying representations in functional generalisations in speech perception: the case of German devoiced stops
Creators: name: Mitterer, Holger
name: Reinisch, Eva
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Listeners can adapt their perceptual categories for speech sounds in response to speakers’ unusual pronunciations. The present study tested whether this generalisation is sensitive to surface or underlying properties of speech by exploiting the devoicing of voiced stops in German. This allows us to assess whether learning on phonetically voiceless stops that are underlyingly voiced generalises to stops that share the same surface form (i.e. voiceless) or the same underlying representation (i.e. voiced). Our results showed only minimal generalisation: learning for (surface) voiceless stops in offset position that are underlyingly voiced generalises to surface and underlying voiceless stops in the same position but neither to voiced nor voiceless stops in intervocalic position. This suggests that listeners extract segments of sufficient acoustic similarity from the input and use them for generalisation of learning in speech perception. The units of perception thereby appear context sensitive rather than abstract phonemes or phonological/articulatory features.
A Coupled Hydrologic-Machine Learning Modelling Framework to Support Hydrologic Modelling in River Basins under Interbasin Water Transfer Regimes
Creators: name: Hrast Essenfelder, Arthur
Publisher: name: Zenodo
Year: 2020

description: Data for the working paper A Coupled Hydrologic-Machine Learning Modelling Framework to Support Hydrologic Modelling in River Basins under Interbasin Water Transfer Regimes
Geomorphology of Mount Ararat/Ağri Daği (Ağri Daği Milli Parki, Eastern Anatolia, Turkey)
Creators: name: Azzoni, Roberto Sergio
name: Zerboni, Andrea
name: Pelfini, Manuela
name: Garzonio, Carlo Alberto
name: Cioni, Raffaello
name: Meraldi, Eraldo
name: Smiraglia, Claudio
name: Diolaiuti, Guglielmina Adele
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: This paper presents a geomorphological map of Mount Ararat/Ağri Daği in Eastern Anatolia (Turkey). Mount Ararat/Ağri Daği is a volcanic complex covered by a unique ice cap in the Near East. The massif is the result of multiple volcanic phases, and present day landforms are the result of subsequent and overlapping glacial, periglacial, and slope processes. The geomorphological mapping of Mount Ararat/Ağri Daği was firstly performed on the basis of desktop studies, by applying remote-sensing investigations using high-resolution satellite imagery (PLEIADES and SPOT images). A preliminary draft of the map was crosschecked and validated in the field as part of an interdisciplinary campaign carried out in the 2014 summer season. All the collected data suggest that the Mount Ararat/Ağri Daği glaciation played a crucial role in the evolution of the landscape and that even today glaciers are significant features in this area. Currently, ice bodies cover 7.28 km2 and include peculiar glacier types. Among these are three well-developed debris-covered glaciers, flowing down along the flanks of the volcano.
title: KLIMONAS-Ch06-A02 –- Secteur F, bâtiments 906 et 907
title: KLIMONAS-Ch06-A02 – Sector F, buildings 906 and 907
Creators: name: BEAUVAIS, Pierre-Antoine
name: FRANEL, Yodrik
name: VIGNE, Jean-Denis
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: Annexe de : Vigne J.-D., Briois F., Guilaine J. (dir.), « Klimonas, un village néolithique pré-céramique ancien à Chypre », Gallia Préhistoire & Paléorient, Supplément international 1,CNRS Éditions, Paris, 2023.
description: Appendix of: Vigne J.-D., Briois F., Guilaine J. (eds.), « Klimonas, an Early Pre-Pottery Neolithic village in Cyprus », Gallia Préhistoire & Paléorient, International Supplement 1, CNRS Éditions, Paris, 2023.
MOESM1 of Effect of grazing on methane uptake from Eurasian steppe of China
Creators: name: Tang, Shiming
name: Zhang, Yujuan
name: Zhai, Xiajie
name: Wilkes, Andreas
name: Wang, Chengjie
name: Wang, Kun
Publisher: name: figshare
Year: 2018
Subjects: subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Additional file 1: Note S1. List of studies used in the meta-analysis.
Additional file 1 of Post-intensive care syndrome screening: a French multicentre survey
Creators: name: Agbakou, Maïté
name: Combet, Margot
name: Martin, Maëlle
name: Blonz, Gauthier
name: Desmedt, Luc
name: Seguin, Amélie
name: Lemarié, Jérémie
name: Zambon, Olivier
name: Reignier, Jean
name: Lascarrou, Jean-Baptiste
name: Ehrmann, Stephan
name: Canet, Emmanuel
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mental Health
subject: Virology

description: Supplementary Material 1
Microarray analysis of circulating microRNAs in familial Mediterranean fever
Creators: name: Wada, Taizo
name: Toma, Tomoko
name: Matsuda, Yusuke
name: Yachie, Akihiro
name: Itami, Saori
name: Y-H Taguchi
name: Murakami, Yoshiki
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Objectives: Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in MEFV. Mutations in exon 10 are associated with typical FMF phenotypes, whereas the pathogenic role of variants in exons 2 and 3 remains uncertain. Recent evidence suggests that circulating microRNAs (miRNAs) are potentially useful biomarkers in several diseases. Therefore, their expression was assessed in FMF. Methods: The subjects were 24 patients with FMF who were between attacks: eight with exon 10 mutations (group A), eight with exon 3 mutations (group B), and eight without exon 3 or 10 mutations (group C). We also investigated eight cases of PFAPA as disease controls. Exosome-rich fractionated RNA was subjected to miRNA profiling by microarray. Results: Using the expression patterns of 26 miRNAs, we classified FMF (groups A, B, and C) and PFAPA with 78.1% accuracy. In FMF patients, groups A and B, A and C, and B and C were distinguished with 93.8, 87.5, and 100% accuracy using 24, 30, and 25 miRNA expression patterns, respectively. Conclusions: These findings suggest that expression patterns of circulating miRNAs differ among FMF subgroups based on MEFV mutations between FMF episodes. These patterns may serve as a useful biomarker for detecting subgroups of FMF.
ANALYZING THE ROLE OF ETHICAL BUSINESS PRACTICES IN BUILDING CONSUMER TRUST AND LONG-TERM BRAND LOYALTY: LEVERAGING CORPORATE ETHICS AS A COMPETITIVE ADVANTAGE
Creators: name: Mbonigaba Celestin*, S. Sujatha** & A. Dinesh Kumar***
Publisher: name: Zenodo
Year: 2024

description: The study, titled The Role of Business Ethics in Building Brand Loyalty, explores the significance of ethical business practices in fostering consumer trust and long-term brand loyalty. The objective was to examine how corporate ethics can serve as a competitive advantage. Using a mixed-methods approach, 500 consumers were surveyed, and interviews with corporate executives from ethical companies were conducted. The results revealed that 68% of consumers prioritize ethical practices when making purchasing decisions, and brands like Patagonia saw a 35% increase in loyalty due to their ethical stance. The study concludes that ethical behavior not only boosts consumer trust but also enhances brand loyalty, positioning businesses for long-term success.
Additional file 1: of Systematic analysis of the lysine malonylome in common wheat
Creators: name: Liu, Jiabin
name: Wang, Guangyuan
name: Lin, Qi
name: Liang, Wenxing
name: Gao, Zhiqiang
name: Mu, Ping
name: Li, Guiquan
name: Song, Limin
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology

description: Figure S1. Systematic analysis of lysine malonylation sites in common wheat. Figure S2. Three representative MS/MS spectra of the malonylated peptides. Figure S3. Validation of lysine malonylation of DHAR by Western blot analysis. Figure S4. Number of malonylation sites per protein in common wheat. Figure S5. GO-based enrichment analysis in terms of cellular component (red bars), molecular function (blue bars) and biological process (green bars). Figure S6. Domain-based enrichment analysis of malonylated proteins. Figure S7. Interaction network of malonylated proteins associated with ribosome. (DOCX 2050 kb)