cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: "Richtig helfen"
Creators: name: Bluma, Simon
Year: 2009

description: Die vorliegende Diplomarbeit beschäftigt sich mit dem Thema der Psychischen Ersten Hilfe im Rettungsdienst. In Zeiten der steigenden Einsatzzahlen und der Personaleinsparungen in jedem Bereich des Dienstleistungssektors führt der Zeitdruck zu immer rascheren Einsatzabwicklungen. PatientInnen im Rettungsdienst befinden sich in einer Ausnahmesituation, in der sie oft aufgebracht sind und sich unsicher fühlen. Die Aufgabe des Rettungsdienstpersonals soll es sein, die PatientInnen neben dem medizinischen Bereich auch psychologisch zu betreuen. Die Komponenten der psychologischen Betreuung bzw. der Psychischen Ersten Hilfe werden immer wieder vergessen. Nach einer kurzen Darstellung der momentanen Ist- Situation beschäftigt sich der erste Teil der Diplomarbeit mit der Theorie um psychologische Betreuung im Rettungsdienst und beinhaltet Grundregeln von Psychischer Erster Hilfe (PEH). Im zweiten Teil der Arbeit sind Interviews mit SanitäterInnen und Sanitätern aufgeführt, die die momentane Ist-Situation schildern, über Probleme in der Anwendung bzw. der Umsetzung sprechen und auf Mankos in der Ausbildung bzw. in der Schulung hinweisen. Im Anschluss daran findet sich ein Kapitel, in dem zwei SchulungsleiterInnen von österreichischen Rettungsorganisationen über die Ausbildung sprechen, über gesetzliche Vorgaben und über Probleme in der Umsetzung. Abschließend nimmt der Notfallpsychologe Dr. Clemens Hausmann zu der momentanen Situation Stellung, erklärt warum die Schulung im Bereich der PEH so bedeutend ist und wie ein Optimum an Ausbildung aussehen würde.
description: This thesis deals with the psychological first aid in emergency medical services. Through downsizing and the simultaneous increase of medical responses, time pressure is resulting in an ever quicker carrying out of work. In an emergency, patients are often stressed and insecure. A paramedic should, aside from medical first aid, also administer psychological assistance. This is often times neglected. After briefly portraying the problems of the current situation, the first part of the thesis deals with the theory of psychological assistance and contains the basic rules of psychological first aid. The second part of the thesis consists of interviews with paramedics who describe the current situation, speak about implementation and execution problems and point out shortcomings in training. In the following chapter two trainers of austrian emergency medical services explain the legal guidelines, talk about the training and implementation problems. The thesis concludes with emergency psychologist Clemens Hausmann MD commenting on the current situation and explaining why special schooling in the area of psychological first aid is of the utmost importance and how an ideal training could look like.
sj-pdf-1-jig-10.1177_1069031X231222417 - Supplemental material for The Customer Success Community: An Exploration of Nonfirm Epistemic Communities and Their Influence on a New Sales Practice
Creators: name: Madruga, Roberto
name: Hilton, Bryson
name: Jung, Hyeyoon
name: Hochstein, Bryan
name: Silva, Edison Renato
Publisher: name: SAGE Journals
Year: 2024
Subjects: Hospitality Management

description: Supplemental material, sj-pdf-1-jig-10.1177_1069031X231222417 for The Customer Success Community: An Exploration of Nonfirm Epistemic Communities and Their Influence on a New Sales Practice by Roberto Madruga, Bryson Hilton, Hyeyoon Jung, Bryan Hochstein and Edison Renato Silva in Journal of International Marketing
sj-docx-1-gph-10.1177_2333794X231223266 – Supplemental material for Childhood Hodgkin Lymphoma in Sub-Saharan Africa: A Systematic Review on the Effectiveness of the Use of Chemotherapy Alone
Creators: name: Kabahweza, Hellen Mugarra
name: Spencer, Angela
Publisher: name: SAGE Journals
Year: 2024
Subjects: subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Nursing not elsewhere classified
subject: Paediatrics

description: Supplemental material, sj-docx-1-gph-10.1177_2333794X231223266 for Childhood Hodgkin Lymphoma in Sub-Saharan Africa: A Systematic Review on the Effectiveness of the Use of Chemotherapy Alone by Hellen Mugarra Kabahweza and Angela Spencer in Global Pediatric Health
Additional file 1 of Humanistic burden of pediatric type 1 diabetes on children and informal caregivers: systematic literature reviews
Creators: name: Allen, Veleka
name: Mahieu, Aymeric
name: Kasireddy, Ellen
name: Shouman, Walid
name: Pourrahmat, Mir-Masoud
name: Collet, Jean-Paul
name: Cherkas, Andriy
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Science Policy

description: Additional File 1: PICO eligibility criteria (Overview of PICO eligibility criteria that were used for study selection in the systematic literature reviews)
Free and total amino acids in human milk in relation to maternal and infant characteristics and infant health outcomes: The Ulm SPATZ health study
Creators: name: Van Sadelhoff, Joris H. J.
name: Siziba, Linda P.
name: Buchenauer, Lisa
name: Mank, Marko
name: Wiertsema, Selma P.
name: Hogenkamp, Astrid
name: Stahl, Bernd
name: Garssen, Johan
name: Rothenbacher, Dietrich
name: Genuneit, Jon
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: human milk
subject: free amino acids
subject: DDC 570 / Life sciences
subject: Breast milk
subject: Breastfeeding
subject: Lactation
subject: Growth
subject: Allergy
subject: FOS: Clinical medicine
subject: Stillen
subject: Laktation
subject: Wachstum
subject: Allergie

description: Free amino acids (FAAs) are important regulators of key pathways necessary for growth, development, and immunity. Data on FAAs in human milk (HM) and their roles in infant development are limited. We investigated the levels of FAAs and total amino acids (TAA, i.e., the sum of conjugated amino acids and FAAs) in HM in relation to infant and maternal characteristics and immunological conditions. FAA and TAA levels in HM sampled at 6 weeks (n = 671) and 6 months (n = 441) of lactation were determined using high-performance liquid chromatography. Child growth was ascertained at 4–5 weeks and at 6–7 months of age. Child allergy and lower respiratory tract infections were assessed in the first years of life. Associations of amino acid (AA) levels in HM with child growth and health outcomes were determined by Spearman correlation and modified Poisson regression, respectively. Free glutamine, glutamate, and serine in 6-week HM positively correlated with infant weight gain in the first 4–5 weeks of age. Maternal pre-pregnancy weight and body mass index (BMI) were negatively correlated with free glutamine and asparagine in 6-week and 6-month HM and positively correlated with the sum of TAAs in 6-month HM, but significance was lost following confounder adjustment. Free glutamine was lower in 6-month HM of mothers with an allergy (either active or non-active). No consistent associations were found between FAAs in HM and child health outcomes. However, potential negative associations were observed between specific FAAs and the risk of food allergy. These results suggest that specific FAAs play a role in infant growth. Moreover, these findings warrant further investigations into the relation of FAAs in HM with infant health outcomes and maternal allergy.
sj-docx-10-gph-10.1177_2333794X231223266 – Supplemental material for Childhood Hodgkin Lymphoma in Sub-Saharan Africa: A Systematic Review on the Effectiveness of the Use of Chemotherapy Alone
Creators: name: Kabahweza, Hellen Mugarra
name: Spencer, Angela
Publisher: name: SAGE Journals
Year: 2024
Subjects: subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Nursing not elsewhere classified
subject: Paediatrics

description: Supplemental material, sj-docx-10-gph-10.1177_2333794X231223266 for Childhood Hodgkin Lymphoma in Sub-Saharan Africa: A Systematic Review on the Effectiveness of the Use of Chemotherapy Alone by Hellen Mugarra Kabahweza and Angela Spencer in Global Pediatric Health
sj-docx-5-gph-10.1177_2333794X231223266 – Supplemental material for Childhood Hodgkin Lymphoma in Sub-Saharan Africa: A Systematic Review on the Effectiveness of the Use of Chemotherapy Alone
Creators: name: Kabahweza, Hellen Mugarra
name: Spencer, Angela
Publisher: name: SAGE Journals
Year: 2024
Subjects: subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Nursing not elsewhere classified
subject: Paediatrics

description: Supplemental material, sj-docx-5-gph-10.1177_2333794X231223266 for Childhood Hodgkin Lymphoma in Sub-Saharan Africa: A Systematic Review on the Effectiveness of the Use of Chemotherapy Alone by Hellen Mugarra Kabahweza and Angela Spencer in Global Pediatric Health
sj-docx-1-tar-10.1177_17534666231221750 – Supplemental material for Referral rates and barriers to lung transplantation based on pulmonary function criteria in interstitial lung diseases: a retrospective cohort study
Creators: name: Deri, Ofir
name: Ovadia, David
name: Huszti, Ella
name: Peled, Michael
name: Saute, Milton
name: Hod, Tammy
name: Onn, Amir
name: Seluk, Lior
name: Furie, Nadav
name: Shafran, Inbal
name: Mass, Ronen
name: Chatterji, Sumit
name: Levy, Liran
Publisher: name: SAGE Journals
Year: 2024
Subjects: Aged Health Care
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Respiratory Diseases

description: Supplemental material, sj-docx-1-tar-10.1177_17534666231221750 for Referral rates and barriers to lung transplantation based on pulmonary function criteria in interstitial lung diseases: a retrospective cohort study by Ofir Deri, David Ovadia, Ella Huszti, Michael Peled, Milton Saute, Tammy Hod, Amir Onn, Lior Seluk, Nadav Furie, Inbal Shafran, Ronen Mass, Sumit Chatterji and Liran Levy in Therapeutic Advances in Respiratory Disease
Additional file 2 of Humanistic burden of pediatric type 1 diabetes on children and informal caregivers: systematic literature reviews
Creators: name: Allen, Veleka
name: Mahieu, Aymeric
name: Kasireddy, Ellen
name: Shouman, Walid
name: Pourrahmat, Mir-Masoud
name: Collet, Jean-Paul
name: Cherkas, Andriy
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Science Policy

description: Additional File 2: Search strategies (Search strategies for database and gray literature searches that were conducted for the systematic literature reviews)
A dynamic power reduction technique for incremental delta sigma modulators
Creators: name: Vogelmann, Patrick
name: Wagner, Johannes
name: Haas, Michael
name: Ortmanns, Maurits
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: Analog-to-digital converter (ADC)
subject: biomedical
subject: delta–sigma
subject: discrete time
subject: dynamic power reduction
subject: slicing
subject: DDC 620 / Engineering & allied operations
subject: Analog-to-digital converters
subject: Discrete-time systems
subject: Biomedizinische Technik

description: This paper presents a dynamic power reduction technique for incremental ΔΣ (I-ΔΣ) modulators. The technique makes use of the unequal weighting of the digital reconstruction filter. The underlying idea is that the input signal samples are not equally weighted in the higher order reconstruction filter. Thus, it is possible to increase the non-idealities of the I-ΔΣ modulator during the runtime of a single Nyquist conversion, thereby saving power. This principal idea is verified by an example design, where the input-referred noise of the first integrator is dynamically increased, which allows for improved efficiency. The proposed technique is readily applicable to every state-of-the-art I-ΔΣ modulator. Furthermore, it is shown that this property can also be used to switch a single-bit digital-to-analog converter (DAC) into a multibit DAC during runtime, thereby greatly improving the achievable signal-to-quantization-noise ratio (SQNR) without suffering from the DAC non-linearity. The prototype I-ΔΣ modulator is manufactured in a 180-nm CMOS technology and achieves a dynamic range/SNDR = 91.5/86.6 dB for a sampling rate of 200 kS/s while consuming l.l mW from a 3-V supply, while the dynamic power reduction method accounts for 30% power savings.
Microwave-assisted synthesis and antitumor evaluation of a new series of thiazolylcoumarin derivatives
Creators: name: Gabr, Moustafa T.
name: El-Gohary, Nadia S.
name: El-Bendary, Eman R.
name: El-Kerdawy, Mohamed M.
name: Ni, Nanting
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2017
Subjects: thiazolylcoumarins
synthesis
antitumor activity
cytotoxic activity
3D pharmacophore elucidation
in silico studies

description: A new series of thiazolylcoumarin derivatives was synthesized. The designed strategy embraced a molecular hybridization approach which involves the combination of the thiazole and coumarin pharmacophores together. The new hybrid compounds were tested for in vitro antitumor efficacy over cervical (Hela) and kidney fibroblast (COS-7) cancer cells. Compounds 5f, 5h, 5m and 5r displayed promising efficacy toward Hela cell line. In addition, 5h and 5r were found to be the most active candidates toward COS-7 cell line. The four active analogs, 5f, 5h, 5m and 5r were screened for in vivo antitumor activity over EAC cells in mice, as well as in vitro cytotoxicity toward W138 normal cells. Results illustrated that 5r has the highest in vivo activity, and that the four analogs are less cytotoxic than 5-FU toward W138 normal cells. In this study, 3D pharmacophore analysis was performed to investigate the matching pharmacophoric features of the synthesized compounds with trichostatin A. In silico studies showed that the investigated compounds meet the optimal needs for good oral absorption with no expected toxicity hazards.
description: EXCLI Journal; 16:Doc1114; ISSN 1611-2156
Additional file 3 of Humanistic burden of pediatric type 1 diabetes on children and informal caregivers: systematic literature reviews
Creators: name: Allen, Veleka
name: Mahieu, Aymeric
name: Kasireddy, Ellen
name: Shouman, Walid
name: Pourrahmat, Mir-Masoud
name: Collet, Jean-Paul
name: Cherkas, Andriy
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Science Policy

description: Additional File 3: Study selection (PRISMA flow diagrams and lists of included studies from the systematic literature reviews)
Complement C5a induces pro-inflammatory microvesicle shedding in severely injured patients
Creators: name: Karasu, Ebru
name: Demmelmaier, Julia
name: Kellermann, Stephanie
name: Holzmann, Karlheinz
name: Köhl, Jörg
name: Schmidt, Christoph Q.
name: Kalbitz, Miriam
name: Gebhard, Florian
name: Huber-Lang, Markus
name: Halbgebauer, Rebecca
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Microvesicle shedding
subject: anaphylatoxin C5a
subject: C5aR1
subject: neutrophils
subject: Polymorphonuclear neutrophils (PMNs)
subject: DDC 610 / Medicine & health
subject: Multiple trauma
subject: Neutrophils
subject: Trauma
subject: Neutrophiler Granulozyt

description: Initially underestimated as platelet dust, extracellular vesicles are continuously gaining interest in the field of inflammation. Various studies addressing inflammatory diseases have shown that microvesicles (MVs) originating from different cell types are systemic transport vehicles carrying distinct cargoes to modulate immune responses. In this study, we focused on the clinical setting of multiple trauma, which is characterized by activation and dysfunction of both, the fluid-phase and the cellular component of innate immunity. Given the sensitivity of neutrophils for the complement anaphylatoxin C5a, we hypothesized that increased C5a production induces alterations in MV shedding of neutrophils resulting in neutrophil dysfunction that fuels posttraumatic inflammation. In a mono-centered prospective clinical study with polytraumatized patients, we found significantly increased granulocyte-derived MVs containing the C5a receptor (C5aR1, CD88) on their surface. This finding was accompanied by a concomitant loss of C5aR1 on granulocytes indicative of an impaired cellular chemotactic and pro-inflammatory neutrophil functions. Furthermore, in vitro exposure of human neutrophils (from healthy volunteers) to C5a significantly increased MV shedding and C5aR1 loss on neutrophils, which could be blocked using the C5aR1 antagonist PMX53. Mechanistic analyses revealed that the interaction between C5aR1 signaling and the small GTPase Arf6 acts as a molecular switch for MV shedding. When neutrophil derived, C5a-induced MV were exposed to a complex ex vivo whole blood model significant pro-inflammatory properties (NADPH activity, ROS and MPO generation) of the MVs became evident. C5a-induced MVs activated resting neutrophils and significantly induced IL-6 secretion. These data suggest a novel role of the C5a-C5aR1 axis: C5a-induced MV shedding from neutrophils results in decreased C5aR1 surface expression on the one hand, on the other hand it leads to profound inflammatory signals which likely are both key drivers of the neutrophil dysfunction which is regularly observed in patients suffering frommultiple traumatic injuries.
Additional file 4 of Humanistic burden of pediatric type 1 diabetes on children and informal caregivers: systematic literature reviews
Creators: name: Allen, Veleka
name: Mahieu, Aymeric
name: Kasireddy, Ellen
name: Shouman, Walid
name: Pourrahmat, Mir-Masoud
name: Collet, Jean-Paul
name: Cherkas, Andriy
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Science Policy

description: Additional File 4: Quality assessment (Summary of quality assessment of included studies from the systematic literature reviews)
Johansen Co-integration Test and VECM: Spatial Analysis of Black Pepper Export Price Among Major Producers
Creators: name: Allan, R.
name: Daud, A.
name: Rosli, A.
Publisher: name: Unknown
Year: 2024
Subjects: subject: Agribusiness
subject: Production Economics
subject: Black Pepper
subject: Johansen Cointegration
subject: VECM

description: Pepper, the world's most used spice has been widely used ever since ancient times. This spice has a high value in terms of monetary due to its medicinal properties. This berry-like spice has never lost its popularity as the world's most traded and used spice. In response to its market value, a study was conducted to analyse the market price movement of black pepper among four world major producers – India, Indonesia, Vietnam, and Malaysia. This study addresses the co-movement among these four major pepper-producing markets by setting the world’s top producer Vietnam, as the dependent variable whilst India, Indonesia, and Malaysia are set as the independent variables. Due to the high price fluctuation of this storable commodity and significant price diversity in different markets, market integration among major producers is essential to study. The unison among the global pepper market is important, not only regarding producers and consumers but also in terms of profit maximization and economic risk management. The study uses the Johansen cointegration approach and the vector error correction model to analyse and evaluate the presence and strength of co-movement of price amongst the market, from the perspective of export freight on board price. The study has found that there are co-movements in the market Vietnam, India, Indonesia, Malaysia, and Sri Lanka, despite obvious price differences and frequent fluctuations. The markets are found to be operating as a single organism. The convergence of pepper prices is found to be significant, and the model is stable for the export of black pepper.
title: Österreich am Ball
Creators: name: Stocker, Thomas
Year: 2009

description: Die vorliegende Diplomarbeit beschäftigt sich mit nationalen Stereotypen und sprachlichen Abgrenzungstendenzen in der Sportberichterstattung der Fußballeuropameisterschaft 2008, vor allem in ihrer Verwendung hinsichtlich der Fußballbe¬gegnung Österreich gegen Deutschland. Den theoretischen Rahmen dieser Arbeit umfasst zum einen der kommunikationswissenschaftliche Zugang, der nach den unterschiedlichen Interpretations- und Selektionskriterien von Journalisten und den Funktionen der Massen¬medien fragt. Zum anderen wird das Wesen der Sportberichterstattung näher beleuchtet und deren wesentliche sprachliche Elemente dargestellt. Der abschließende theoretische Teil umfasst eine kurze historische Vertiefung über die Eckpfeiler der Entstehung eines nationalen Österreichbewusstseins, den Beitrag des Sports zur österreichischen Identitäts¬findung und den sportlichen Auseinandersetzungen mit Deutschland, die in einer gewissen Weise auch immer der Artikulation eines österreichischen nationalen Bewusstseins dienten. Im empirischen Teil dieser Arbeit wird das Forschungsinteresse anhand der Forschungs-fragen eingeschränkt. Ziel der Arbeit ist es zu untersuchen, ob in den Untersuchungsgegenständen der Sportberichterstattung der Europameisterschaft gewisse Sprachmuster verwendet werden, die das eigene Nationale thematisieren und gegenüber dem Anderen, insbesondere gegenüber Deutschland, in ihrer Artikulation Abgrenzung evozieren. Mit den erstellten Hypothesen wird der Untersuchungsgegenstand, der sich aus einer Boulevardzeitung (Österreich) und einer Qualitätszeitung („Stan¬dard“) zusammensetzt, im weiteren Verlauf quantitativ analysiert. Zur Überprüfung der Hypothesen wurde ein Kategoriensystem erstellt, das im Codebuch der vorliegenden Arbeit dargestellt wird. Mit den Ergebnissen der Analyse kann belegt werden, dass für den Zeitraum der Untersu¬chung der Europa-Meisterschaftsberichterstattung, speziell für das Spiel Österreich gegen Deutschland, nationale Elemente thematisiert werden, Emotionen geweckt werden und sprachliche Abgrenzungstendenzen verwendet werden. Auch wenn die Ergebnisse zwischen der Boulevard- und der Qualitätszeitung hinsichtlich der untersuchten Merkmale differieren, so kann der Sportberichterstattung eine gewisse Tendenz zur Verwendung dieser sprachlichen Stilmittel attestiert werden, die das „Eigene“ ansprechen und gegenüber dem „Anderen“ abgrenzen. Dies kann vor allem für die Berichterstattung über die sportliche Rivalität zwischen Österreich und Deutschland während der Europameisterschaft belegt werden.
Jahresbericht der Universität Ulm 2017
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: Research; Ulm
subject: Universities; Germany; Ulm
subject: DDC 370 / Education
subject: Universities and colleges; Germany
subject: Universität Ulm
subject: Forschungsbericht

description: Jahresbericht der Universität Ulm 2017
What controls native plant regeneration in urban forest restoration?
Creators: name: Kiri Joy Wallace
name: Laughlin, Daniel C.
name: Clarkson, Bruce D.
Publisher: name: F1000Research
Year: 2017

description: Background/Question/Methods:
Restoring forest structure, composition and function is an important component of urban land management, but we lack a clear understanding of the mechanisms driving native tree regeneration beneath a planted forest canopy. We hypothesized that light availability, competition with exotic weeds, and microclimate mediate the establishment of the next generation of native trees in restored forests. We investigated relationships between environmental conditions and the plant community in 27 restored urban forests spanning 3 to 70 years in age and in both unrestored and remnant urban forests and used structural equation modelling to determine the direct and indirect drivers of native tree regeneration in the restored forests.

Results/Conclusions:
Compared to remnant forest, unrestored forest had significantly more light reaching the forest floor annually, exotic weed cover was greater, and there was marginally less native tree regeneration. In restored forests, light transmission through the canopy was reduced to levels found in remnant forests within 20 years of planting, and shortly thereafter herbaceous exotic weeds in the understorey declined and soil temperatures stabilised. Contrary to expectations, light availability was not a direct driver of tree regeneration, but canopy openness did regulate weed cover and soil temperature variation, which were the key drivers of native tree seedling regeneration. These results imply that ecosystem properties change predictably after initial restoration plantings, and that reaching critical thresholds in some ecosystem properties makes conditions suitable for the regeneration of late successional species, which is vital for restoration success and long-term ecosystem sustainability. Abiotic and biotic conditions that promote tree regeneration will likely be present in forests with a basal area ≥ 27 m2/ha. We recommend that urban forest restoration plantings be designed to promote rapid canopy closure to reduce light availability, suppress herbaceous weeds, and stabilize the microclimate.
Database resources and their functionalities: ConsensusPathDB and ToxDB
Creators: name: Barel, Gal
name: Hardt, Christopher
name: Kamburov, Atanas
name: Herwig, Ralf
Publisher: name: F1000Research
Year: 2017

description: We present two database resources, ConsensusPathDB and ToxDB, display their functionalities and demonstrate how they can be used to carry out a system-wide approach for the HeCaToS project. ConsensusPathDB consists of a comprehensive collection of molecular interaction data integrated from 32 different public repositories and a web interface featuring a set of computational methods and visualization tools to explore these data. ToxDB was developed for the analysis of the functional consequences of drug treatment at the pathway level, and thus consists of 2,282 pathway concepts as well as numerical response scores for 437 drugs and 7,467 different experimental conditions. For the HeCaToS project we have used both resources and established an integrative approach for the identification and prediction of human liver and heart drug induced toxicity.
The antihypertensive drug Telmisartan protects Oligodendrocytes from Cholesterol accumulation and promotes differentiation by a PPAR-γ-mediated mechanism
Creators: name: Bernardo, Antonietta
name: Malara, Mariagiovanna
name: Bertuccini, Lucia
name: De Nuccio, Chiara
name: Visentin, Sergio
name: Minghetti, Luisa
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: cholesterol accumulation
subject: Niemann Pick type C disease
subject: myelination
subject: PPAR-γ
subject: oligodendrocyte progenitors
subject: drug repositioning
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health
subject: Oligodendrocyte precursor cells
subject: Cholesterol; Metabolism
subject: Glycogen storage disease type I
subject: PPAR gamma
subject: Niemann-Pick-Krankheit
subject: Peroxisomen-Proliferator-aktivierter Rezeptor
subject: Myelogenese
subject: Cholesterin

description: Our previous studies have demonstrated that specific peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists play a fundamental role in oligodendrocyte progenitor (OP) differentiation, protecting them against oxidative and inflammatory damage. The antihypertensive drug Telmisartan (TLM) was shown to act as a PPAR-γ modulator. This study investigates the TLM effect on OP differentiation and validates its capability to restore damage in a pharmacological model of Niemann-Pick type C (NPC) disease through a PPAR-γ-mediated mechanism. For the first time in purified OPs, we demonstrate that TLM-induced PPAR-γ activation downregulates the type 1 angiotensin II receptor (AT1), the level of which naturally decreases during differentiation. Like other PPAR-γ agonists, we show that TLM promotes peroxisomal proliferation and promotes OP differentiation. Furthermore, TLM can offset the OP maturation arrest induced by a lysosomal cholesterol transport inhibitor (U18666A), which reproduces an NPC1-like phenotype. In the NPC1 model, TLM also reduces cholesterol accumulation within peroxisomal and lysosomal compartments and the contacts between lysosomes and peroxisomes, revealing that TLM can regulate intracellular cholesterol transport, crucial for myelin formation. Altogether, these data indicate a new potential use of TLM in hypomyelination pathologies such as NPC1, underlining the possible repositioning of the drug already used in other pathologies.
НИЗОЛИ ОИЛАЛАРДА ОИЛАВИЙ НИЗОЛАРНИНГ ОЛДИНИ ОЛИШ БОРАСИДА АЙРИМ МУЛОҲАЗАЛАР
Creators: name: Бахтиёрова, Эьзозахон
Publisher: name: Zenodo
Year: 2024

description: Замонавий жамиятларда низо жамият ҳаётининг узвий кўринишидир. Масалан, Германияда фаолият олиб борувчи йирик компанияларда низо предмети билан ишлайдиган махсус бўлимлар ташкил этилган. Унинг вазифаси маъмурий, ижтимоий-меҳнат низоларини ўз вақтида, бошланғич фазасида бартараф этишдан иборат (collaborative law, procedure collaborative).
sj-docx-1-imj-10.1177_10815589231220573 – Supplemental material for Epidemiology and outcomes of previously healthy critically ill patients with COVID-19: A population-based cohort
Creators: name: Oud, Lavi
name: Garza, John
Publisher: name: SAGE Journals
Year: 2024
Subjects: Medicine

description: Supplemental material, sj-docx-1-imj-10.1177_10815589231220573 for Epidemiology and outcomes of previously healthy critically ill patients with COVID-19: A population-based cohort by Lavi Oud and John Garza in Journal of Investigative Medicine
Gut microbiota individuality is contingent on temporal scale and age in wild meerkats
Creators: name: Risely, Alice
name: Schmid, Dominik W. W.
name: Müller-Klein, Nadine
name: Wilhelm, Kerstin
name: Clutton-Brock, Tim H.
name: Manser, Marta B.
name: Sommer, Simone
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: temporal dynamics
subject: host–microbiota interactions
subject: gut microbiome
subject: meerkats
subject: repeatability
subject: intraclass correlation coefficient
subject: DDC 570 / Life sciences
subject: Survival
subject: Dynamics
subject: Überleben

description: Inter-individual differences in gut microbiota composition are hypothesized to generate variation in host fitness – a premise for the evolution of host-gut microbe symbioses. However, recent evidence suggests that gut microbial communities are highly dynamic, challenging the notion that individuals harbour unique gut microbial phenotypes. Leveraging a long-term dataset of wild meerkats, we reconcile these concepts by demonstrating that the relative importance of identity for shaping gut microbiota phenotypes depends on the temporal scale. Across meerkat lifespan, year-to-year variation overshadowed the effects of identity and social group in predicting gut microbiota composition, with identity explaining on average less than 2% of variation. However, identity was the strongest predictor of microbial phenotypes over short sampling intervals (< 2 months), predicting on average 20% of variation. The effect of identity was also dependent on meerkat age, with the gut microbiota becoming more individualized and stable as meerkats aged. Nevertheless, whilst the predictive power of identity was negligible after two months, gut microbiota composition remained weakly individualised compared to that of other meerkats for up to one year. These findings illuminate the degree to which individualised gut microbial signatures can be expected, with important implications for the time frames over which gut microbial phenotypes may mediate host physiology, behaviour and fitness in natural populations.
Guideline adherence and registry recruitment of congenital primary hypothyroidism: data from the german registry for congenital hypothyroidism (HypoDok)
Creators: name: Thomann,
name: Tittel,
name: Voss,
name: Oeverink,
name: Palm,
name: Fricke-Otto,
name: Kapelari,
name: Holl,
name: Woelfle,
name: Bettendorf,
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: standardized documentation
subject: quality assurance
subject: longitudinal comparison
subject: multicenter database
subject: DDC 150 / Psychology
subject: DDC 610 / Medicine & health
subject: Quality assurance
subject: Qualitätssicherung

description: Neonatal screening for congenital primary hypothyroidism (CH) is mandatory in Germany but medical care thereafter remains inconsistent. Therefore, the registry HypoDok of the German Society of Pediatric Endocrinology and Diabetology (DGKED) was analyzed to evaluate the implementation of evidence-based guidelines and to assess the number of included patients. Inclusion criteria were (i) date of birth between 10/2001 and 05/2020 and (ii) increased thyroid-stimulating hormone (TSH) at screening and/or confirmation. The cohort was divided into before (A) and after (B) guideline publication in 02/2011, to assess the guideline’s influence on medical care. A total of 659 patients were analyzed as group A (n = 327) and group B (n = 332) representing 17.5% and 10.3% of CH patients identified in the German and Austrian neonatal screening program during the respective time period. Treatment start and thyroxine doses were similar in both groups and consistent with recommendations. Regular follow-ups were documented. In the first three years of life, less than half of the patients underwent audiometry; developmental assessment was performed in 49.3% (A) and 24.8% (B) (p < 0.01). Documentation of CH patient care by pediatric endocrinologists seemed to be established, however, it reflected only a minority of the affected patients. Therefore, comprehensive documentation as an important instrument of quality assurance and evidence-based medicine should be legally enforced and officially funded in order to record, comprehend, and optimize care and outcome in patients with rare diseases such as CH.
sj-docx-1-tct-10.1177_15330338231223080 - Supplemental material for The Potential Transcriptomic and Metabolomic Mechanisms of ATO and ATRA in Treatment of FLT3-ITD Acute Myeloid Leukemia
Creators: name: Peng, Chun-Jin
name: Fan, Zhong
name: Luo, Jie-Si
name: Wang, Li-Na
name: Li, Yu
name: Liang, Cong
name: Zhang, Xiao-Li
name: Luo, Xue-Qun
name: Huang, Li-Bin
name: Tang, Yan-Lai
Publisher: name: SAGE Journals
Year: 2024
Subjects: Oncology and Carcinogenesis not elsewhere classified
Radiology and Organ Imaging
Biochemistry

description: Supplemental material, sj-docx-1-tct-10.1177_15330338231223080 for The Potential Transcriptomic and Metabolomic Mechanisms of ATO and ATRA in Treatment of FLT3-ITD Acute Myeloid Leukemia by Chun-Jin Peng, MD, Zhong Fan, MD, Jie-Si Luo, MD, Li-Na Wang, MD, Yu Li, MD, Cong Liang, MD, Xiao-Li Zhang, MD, Xue-Qun Luo, MD, Li-Bin Huang, MD, and Yan-Lai Tang, MD in Technology in Cancer Research & Treatment
In-situ monitoring of additives during CO2 gas hydrate formation
Creators: name: Schwenk, Matthias
name: Katzir, Abraham
name: Mizaikoff, Boris
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: CO2 gas hydrate formation
subject: Carbon capture and storage (CCS)
subject: Mid-infrared fiberoptic evanescent field sensing
subject: DDC 540 / Chemistry & allied sciences
subject: Hydrocarbon
subject: Carbon sequestration
subject: Fiber optics
subject: Carbon dioxide capture and storage
subject: Gasspeicherung
subject: Faseroptik

description: Research activities on the reduction of carbon dioxide emissions via effective carbon capture and storage (CCS) techniques are steadily increasing with the concept of storing CO2 as hydrates among the most prominently discussed strategies. The present study utilizes mid- infrared (MIR) fiberoptic evanescent field sensing techniques as a promising in-situ monitoring tool for investigating molecular changes occurring during CO2 hydrate formation. The identification and evaluation of characteristic IR absorption features associated with additive molecules (here, THF and SDS) and their changes during hydrate formation were pronounced via studies in D2O next to H2O as the hydrate forming matrix. By correlating IR-spectroscopic data with continuously recorded pressure and temperature traces, hypotheses on the involvement and promoting effect of such additives during carbon dioxide gas hydrate formation were experimentally consolidated.
sj-docx-1-aut-10.1177_13623613231218314 – Supplemental material for Exploring social touch in autistic and non-autistic adults via a self-report body-painting task: The role of sex, social context and body area
Creators: name: Mello, Manuel
name: Fusaro, Martina
name: Aglioti, Salvatore Maria
name: Minio-Paluello, Ilaria
Publisher: name: SAGE Journals
Year: 2024
Subjects: Psychology not elsewhere classified
Psychiatry (incl. Psychotherapy)
Public Health and Health Services not elsewhere classified
Education
Special Education and Disability

description: Supplemental material, sj-docx-1-aut-10.1177_13623613231218314 for Exploring social touch in autistic and non-autistic adults via a self-report body-painting task: The role of sex, social context and body area by Manuel Mello, Martina Fusaro, Salvatore Maria Aglioti and Ilaria Minio-Paluello in Autism
User-adaptive statistical dialogue management using OpenDial
Creators: name: Wagner, Nicolas
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: Spoken Dialogue System
subject: Adaptive Dialogue Management
subject: DDC 000 / Computer science, information & general works
subject: Automatic speech recognition
subject: Machine learning
subject: Maschinelles Lernen
subject: Automatische Spracherkennung

description: In Spoken Dialogue Systems, two techniques are currently used to create an optimal dialogue policy: hand-crafted rules and statistical procedures basing on machine learning. However, both types are not sufficient in complex areas where only limited training data is available. This thesis thus examines a hybrid approach to dialogue management that intents to combine the benefits of both rule-based and statistical methods. For this purpose, probabilistic rules are employed which depend on unknown parameters. Afterwards, these parameters are trained with supervised learning. Furthermore, the dialogue manager is designed to be adaptive to the user's cultural background and emotional condition as this is supposed to have a crucial influence on the conversational behaviour. The configuration is then investigated in the context of the KRISTINA domain. The conducted experiments reveal that it is possible to include emotional and cultural features in the dialogue management.
sj-docx-5-sjp-10.1177_14034948231185938 – Supplemental material for The relation between economic stressors and higher education students’ mental health during the initial outbreak of the COVID-19 pandemic
Creators: name: Buffel, Veerle
name: Wouters, Edwin
name: Cullati, Stephane
name: Tancredi, Stefano
name: Van Eeckert, Nina
name: Van de Velde, Sarah
Publisher: name: SAGE Journals
Year: 2024
Subjects: Public Health and Health Services not elsewhere classified

description: Supplemental material, sj-docx-5-sjp-10.1177_14034948231185938 for The relation between economic stressors and higher education students’ mental health during the initial outbreak of the COVID-19 pandemic by Veerle Buffel, Edwin Wouters, Stephane Cullati, Stefano Tancredi, Nina Van Eeckert and Sarah Van de Velde in Scandinavian Journal of Public Health
title: Geoscience Education for the Young Generation: mileko - The Mineralogical Science Kit
Creators: name: Mrosko ,  Maria
name: Fischer ,  Lennart A.
name: Hecht ,  Lutz
name: Joachim-Mrosko ,  Bastian
name: Junge ,  Malte
name: Simon ,  Gilla
name: Stalder ,  Roland
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: Geosciences only play a minor role in today’s German and Austrian school curricula, although being strongly related to important topics such as climate change and sustainability of resources. The Mineralogical Science Kit (Mineralogischer Lehrkoffer ‘mileko’) aims at bringing back geoscientific and mineralogical contents into STEAM-fields (science, technology, engineering, art, mathematics) by linking mineralogy to regular teaching subjects. In 5 different modules pupils can not only discover the world of rocks and minerals but also get an understanding of important principles and processes such as redox reactions when extracting copper from ore (chemistry), the density of rocks which can be linked to the structure of the Earth’s interior (physics, geography), or how the inner structure of materials affects their outer appearance by exploring natural crystalline bodies and their geometry (chemistry, mathematics). Since 2014, about 650 boxes were produced and sent to schools and museums all over Germany. 2020 marked the starting point for the implementation of a rent-a-scientist-program as well as a network of lending stations, where boxes can be borrowed by schools or be used to host workshops for teachers and pupils in-house. In 2021, the development of a video format is planned that will improve and expand the applicability of the Mineralogical Science Kit by presenting relevant geoscientific topics to a wider public. This new digital format combined with presence activities like workshops and school visits will enhance discussions between children, teachers and scientific experts resulting in knowledge transfer from the scientific community to the public.
sj-docx-1-sjp-10.1177_14034948231219833 – Supplemental material for A taste of ambrosia: Do Olympic medalists live longer than Olympic losers?
Creators: name: Kovbasiuk, Anna
name: Ciechanowski, Leon
name: Jemielniak, Dariusz
Publisher: name: SAGE Journals
Year: 2024
Subjects: Public Health and Health Services not elsewhere classified

description: Supplemental material, sj-docx-1-sjp-10.1177_14034948231219833 for A taste of ambrosia: Do Olympic medalists live longer than Olympic losers? by Anna Kovbasiuk, Leon Ciechanowski and Dariusz Jemielniak in Scandinavian Journal of Public Health
Additional file 9 of Changes in the innate immune response to SARS-CoV-2 with advancing age in humans
Creators: name: Agrawal, Sudhanshu
name: Tran, Michelle Thu
name: Jennings, Tara Sinta Kartika
name: Soliman, Marlaine Maged Hosny
name: Heo, Sally
name: Sasson, Bobby
name: Rahmatpanah, Farah
name: Agrawal, Anshu
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 9
Neuerkennungen in der Schule von Athen
Creators: name: Keim, Frank
Publisher: name: Universität Ulm
Year: 2017
Subjects: subject: Hypatia
subject: Philolaus
subject: Lukrez
subject: Diogenes Laertius
subject: Raffael: Schule von Athen
subject: Renaissance
subject: Sokrates
subject: Damo
subject: Vater Jesu
subject: Telauges
subject: Raffaelo
subject: DDC 100 / Philosophy
subject: Raphael, 1483-1520; School of Athens

description: Erstmals werden Damo und Telauges, die Tochter und der Sohn des Pythagoras, sowie Philolaos von Kroton im Fresko erkannt. Weitere Neubestimmungen gelten der Mathematikerin Hypatia aus Alexandria, dem Philosophen Lukrez und Diogenes Laertius, dem Verfasser der Philosophenviten. Statt Diogenes von Sinope wird der sterbende Sokrates angenommen. Außerdem wird die Vermutung geäußert, Raffael habe den Vater Jesu abgebildet. Der Artikel mündet in einen Schlussbericht zur Schule von Athen, in dem alle Neuidentifikationen des Autors seit 2005 aufgenommen sind.
sj-doc-1-npx-10.1177_1934578X231220119 - Supplemental material for Optimizing Ultrasonic Extraction and Purification of Nuciferine With Response Surface Method
Creators: name: Ren, Xinshui
name: Wu, Mengdie
name: Liu, Simin
name: Pan, Hongzhi
Publisher: name: SAGE Journals
Year: 2024
Subjects: Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, sj-doc-1-npx-10.1177_1934578X231220119 for Optimizing Ultrasonic Extraction and Purification of Nuciferine With Response Surface Method by Xinshui Ren, Mengdie Wu, Simin Liu and Hongzhi Pan in Natural Product Communications
Modelling heterogeneously bleached single-grain equivalent dose distributions: Implications for the reliability of burial dose determination
Creators: name: Peng, J
name: Li, Bo
name: Jacobs, Zenobia
Publisher: name: University of Wollongong
Year: 2025
Subjects: classificationCode: 3703
subject: Geochemistry
subject: FOS: Earth and related environmental sciences
classificationCode: 3705
subject: Geology
classificationCode: 4301
subject: Archaeology
classificationCode: 37
subject: Earth sciences
classificationCode: 3709
subject: Physical geography and environmental geoscience

description: In optical dating, incomplete and heterogeneous resetting (“bleaching”) of the luminescence signal measured from mineral grains since the last episode of transport and deposition is commonly observed for sedimentary samples. As a result, different grains could have different equivalent dose (De) values at the time of deposition. For such samples, statistical treatment of the De distribution is required to estimate the burial dose. This study aims to assess the reliability of burial dose determination for heterogeneously bleached samples using the minimum age model (MAM). We modeled heterogeneous bleaching processes under various bleaching scenarios and simulated the resulting single-grain De distributions using a Monte Carlo method. Various factors that could potentially affect the reliability of burial dose estimates are investigated, including the distribution of residual dose, proportion of fully bleached grains, baseline dose, sample size, and unaccounted between-grain standard deviation. The simulation results reveal that the performance of the model depends primarily on the residual dose distribution. The proportion of fully bleached grains has the most influence on the reliability of MAM burial dose estimates.
Jahresbericht der Deutschen Gesellschaft für Epidemiologie 2016 – 2017
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: Jahresbericht DGEpi
subject: DDC 610 / Medicine & health
subject: Epidemiology
subject: Epidemiologie

description: Die "Deutsche Gesellschaft für Epidemiologie (DGEpi) e.V." ist eine unabhängige wissenschaftliche Fachgesellschaft, die im Jahr 2005 gegründet wurde. Sie vertritt das Fach Epidemiologie in Forschung und Lehre und ist aus der Deutschen Arbeitsgemeinschaft für Epidemiologie (DAE) hervorgegangen. Im Zwei-Jahresbericht wird über die Aktivitäten der DGEpi in den Jahren 2016 und 2017 berichtet.
การรับรู้ประสิทธิผลการบริหารลูกค้าสัมพันธ์ ความไว้วางใจคุณภาพบริการ ที่ส่งผลต่อความภักดีของลูกค้าที่ใช้บริการสถานตรวจสภาพรถเอกชนในจังหวัดพระนครศรีอยุธยา
Creators: name: สายสวาท  แสงเมา
name: เสนีย์  พวงยาณี
Publisher: name: มหาวิทยาลัยเทคโนโลยีราชมงคลสุวรรณภูมิ
Year: 2018
Subjects: การรับรู้ประสิทธิผลการบริหารลูกค้าสัมพันธ์
ความไว้วางใจคุณภาพบริการ
ความภักดี

description: วารสารวิชาการและวิจัย มทร.พระนคร สาขามนุษยศาสตร์และสังคมศาสตร์, 3, 1, 23-33
sj-docx-1-cpx-10.1177_21677026231217312 – Supplemental material for Criminalizing Psychopathology in Black Americans: Racial and Gender Differences in the Relationship Between Psychopathology and Arrests
Creators: name: Brownlow, Briana N.
name: Harmon, Kassidie S.
name: Pek, Jolynn
name: Cheavens, Jennifer S.
name: Moore, James L.
name: Coccaro, Emil F.
Publisher: name: SAGE Journals
Year: 2024
Subjects: Psychology not elsewhere classified

description: Supplemental material, sj-docx-1-cpx-10.1177_21677026231217312 for Criminalizing Psychopathology in Black Americans: Racial and Gender Differences in the Relationship Between Psychopathology and Arrests by Briana N. Brownlow, Kassidie S. Harmon, Jolynn Pek, Jennifer S. Cheavens, James L. Moore and Emil F. Coccaro in Clinical Psychological Science
วิธีการจัดการความขัดแย้งของผู้บริหารสถานศึกษา โรงเรียนสังกัดกลุ่มกรุงเทพใต้
Creators: name: กุศล  ชุมมุง
name: วิไล  ตั้งจิตสมคิด
name: สุรศักดิ์  หลาบมาลา
Publisher: name: มหาวิทยาลัยราชภัฎธนบุรี
Year: 2018
Subjects: การบริหารความขัดแย้ง
ผู้บริหารสถานศึกษา
โรงเรียนกลุ่มกรุงเทพใต้

description: วารสารวิชาการและวิจัย มทร.พระนคร สาขามนุษยศาสตร์และสังคมศาสตร์, 3, 1, 34-45
ปัจจัยการตัดสินใจของผู้ปกครองในการส่งบุตรหลานเข้าโรงเรียนอนุบาลเอกชนในพื้นที่สำนักงานเขตยานนาวา
Creators: name: ทิพย์สุดา  เนินทราย
name: วิไล  ตั้งจิตสมคิด
name: สุรศักดิ์  หลาบมาลา
Publisher: name: มหาวิทยาลัยราชภัฎธนบุรี
Year: 2018
Subjects: ปัจจัยการตัดสินใจ
อนุบาลเอกชน

description: วารสารวิชาการและวิจัย มทร.พระนคร สาขามนุษยศาสตร์และสังคมศาสตร์, 3, 1, 46-62