title: ÐÐ¾ÑÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ ÐºÐ¾ÑÑ Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð° Ð² ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸ÑÐµÑÐºÐ¾Ð¼ Ð¾ÑÐ°Ð³Ðµ Ð¿ÑÐ¸ ÑÐ°ÑÐ¼Ð°ÐºÐ¾ÑÐµÐ·Ð¸ÑÑÐµÐ½ÑÐ½Ð¾Ð¹ ÑÐ¾ÑÐ¼Ðµ Ð²Ð¸ÑÐ¾ÑÐ½Ð¾Ð¹ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸ Ñ Ð´ÐµÑÐµÐ¹
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Morphological features of the cerebral cortex in the epileptic focus in pharmacoresistant form of temporal lobe epilepsy in children
Creators: name: ÐÑÐº, ÐÐ¸ÐºÑÐ¾ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð²Ð¸ÑÐ¾ÑÐ½Ð°Ñ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ñ
ÑÐ°ÑÐ¼Ð°ÐºÐ¾ÑÐµÐ·Ð¸ÑÑÐµÐ½ÑÐ½Ð¾ÑÑÑ
ÑÐ¾ÐºÐ°Ð»ÑÐ½Ð°Ñ ÐºÐ¾ÑÑÐ¸ÐºÐ°Ð»ÑÐ½Ð°Ñ Ð´Ð¸ÑÐ¿Ð»Ð°Ð·Ð¸Ñ
ÐºÐ¾ÑÐ° Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð°
Ð³Ð»Ð¸Ð°Ð»ÑÐ½ÑÐµ ÐºÐ»ÐµÑÐºÐ¸
temporal lobe epilepsy
pharmacoresistance
focal cortical dysplasia
cerebral cortex
glial cells

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description: Temporal epilepsy is a disease of the central nervous system, often debuting in childhood and affecting the morphofunctional maturation of the brain. Up to 30% of epilepsy cases are pharmacoresistant. The study of morphologic changes of the epileptic focus area is necessary to understand the mechanisms of disease pathogenesis, therefore, the study of morphologic changes of the epileptic focus area in children operated for focal temporal lobe epilepsy is relevant to date. For this purpose, postoperative tissue material of the temporal lobe of children obtained during surgical treatment was studied. Hematoxylin-eosin and thionin staining using the Nissl method were performed to detect neuronal pathologies, and immunohistochemical analysis was performed to study the state of glia and to calculate the neuron-glial index. In the zone of epileptic activity various cellular abnormalities combined with impaired cortical lamination, astrogliosis in the subpial zone and white matter, and an increased number of reactive microglial cells were detected. This complex of changes reflects the complex pathogenetic interactions that develop during the formation of an epileptic focus, the study of which will help to understand the pathogenesis of epilepsy.