cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
BindingDB Entry 50020635: Strategies of Targeting CK2 in Drug Discovery: Challenges, Opportunities, and Emerging Prospects.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Casein kinase II subunit alpha, Casein kinase II subunit alpha 3, Casein kinase II subunit alpha', Casein kinase II subunit beta, Dual specificity protein kinase CLK2, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity tyrosine-phosphorylation-regulated kinase 1B, Platelet-derived growth factor receptor alpha/beta, SRSF protein kinase 1, Serine/threonine-protein kinase pim-1, Serine/threonine-protein kinase pim-2, Serine/threonine-protein kinase pim-3, and TRAF2 and NCK-interacting protein kinase, Sichuan University, Affinity

description: Small molecule binding data for protein Casein kinase II subunit alpha, Casein kinase II subunit alpha 3, Casein kinase II subunit alpha', Casein kinase II subunit beta, Dual specificity protein kinase CLK2, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity tyrosine-phosphorylation-regulated kinase 1B, Platelet-derived growth factor receptor alpha/beta, SRSF protein kinase 1, Serine/threonine-protein kinase pim-1, Serine/threonine-protein kinase pim-2, Serine/threonine-protein kinase pim-3, and TRAF2 and NCK-interacting protein kinase, Uniprot P05622, P11309, P19784, P26618, P49760, P67870, P68400, Q13627, Q86V86, Q8NEV1, Q96SB4, Q9P1W9, Q9UKE5, and Q9Y463
BindingDB Entry 50020634: Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Protein cereblon, Signal transducer and activator of transcription 5A, Signal transducer and activator of transcription 5B, and Signal transducer and activator of transcription 6, University of Michigan, Affinity

description: Small molecule binding data for protein Protein cereblon, Signal transducer and activator of transcription 5A, Signal transducer and activator of transcription 5B, and Signal transducer and activator of transcription 6, Uniprot P42226, P42229, P51692, and Q96SW2
BindingDB Entry 50020633: Structure-Activity Relationship of Novel Pyrimidine Derivatives with Potent Inhibitory Activities against
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Serine/threonine-protein kinase PknB, Sichuan University, Affinity

description: Small molecule binding data for protein Serine/threonine-protein kinase PknB, Uniprot P9WI81
Bubalus bubalis Water
Creators: name: Kazim, Abdul-Rahman
name: Houssaini, Jamal
name: Tappe, Dennis
name: Heo, Chong-Chin
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Artiodactyla
Bovidae
Bubalus
Bubalus bubalis

description: Bubalus bubalis (Linnaeus, 1758) Water buffalo—Kerbau sawah
Haematopinus tuberculatus (Burmeister, 1838)
description: Published as part of Kazim, Abdul-Rahman, Houssaini, Jamal, Tappe, Dennis & Heo, Chong-Chin, 2022, An annotated checklist of sucking lice (Phthiraptera: Anoplura) from domestic and wild mammals in Malaysia, with lists of hosts and pathogens, pp. 301-336 in Zootaxa 5214 (3) on page 325, DOI: 10.11646/zootaxa.5214.3.1, http://zenodo.org/record/7389119
BindingDB Entry 50020629: Discovery of CZS-241: A Potent, Selective, and Orally Available Polo-Like Kinase 4 Inhibitor for the Treatment of Chronic Myeloid Leukemia.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: High affinity nerve growth factor receptor and Serine/threonine-protein kinase PLK4, Shenyang Pharmaceutical University, Affinity

description: Small molecule binding data for protein High affinity nerve growth factor receptor and Serine/threonine-protein kinase PLK4, Uniprot O00444 and P04629
Capra hircus Linnaeus 1758
Creators: name: Kazim, Abdul-Rahman
name: Houssaini, Jamal
name: Tappe, Dennis
name: Heo, Chong-Chin
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Artiodactyla
Bovidae
Capra
Capra hircus

description: Capra hircus Linnaeus, 1758 Domestic goat—Kambing
Linognathus africanus Kellogg & Paine, 1911
description: Published as part of Kazim, Abdul-Rahman, Houssaini, Jamal, Tappe, Dennis & Heo, Chong-Chin, 2022, An annotated checklist of sucking lice (Phthiraptera: Anoplura) from domestic and wild mammals in Malaysia, with lists of hosts and pathogens, pp. 301-336 in Zootaxa 5214 (3) on page 325, DOI: 10.11646/zootaxa.5214.3.1, http://zenodo.org/record/7389119
BindingDB Entry 50020622: Identification of M4205─A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Macrophage colony-stimulating factor 1 receptor, Mast/stem cell growth factor receptor Kit, Platelet-derived growth factor receptor alpha, Platelet-derived growth factor receptor beta, Receptor-type tyrosine-protein kinase FLT3, and Tyrosine-protein kinase Lck, Merck Healthcare, Affinity

description: Small molecule binding data for protein Macrophage colony-stimulating factor 1 receptor, Mast/stem cell growth factor receptor Kit, Platelet-derived growth factor receptor alpha, Platelet-derived growth factor receptor beta, Receptor-type tyrosine-protein kinase FLT3, and Tyrosine-protein kinase Lck, Uniprot P06239, P07333, P09619, P10721, P16234, and P36888
BindingDB Entry 50020621: Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: 17-beta-hydroxysteroid dehydrogenase 13 and Estradiol 17-beta-dehydrogenase 11, Boehringer Ingelheim Pharma, Affinity

description: Small molecule binding data for protein 17-beta-hydroxysteroid dehydrogenase 13 and Estradiol 17-beta-dehydrogenase 11, Uniprot Q7Z5P4, Q8NBQ5, and Q8VCR2
Sus barbatus Bornean
Creators: name: Kazim, Abdul-Rahman
name: Houssaini, Jamal
name: Tappe, Dennis
name: Heo, Chong-Chin
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Artiodactyla
Suidae
Sus
Sus barbatus

description: Sus barbatus (Müller, 1838) Bornean bearded pig—Babi bodoh
Haematopinus ludwigi Weisser, 1974
description: Published as part of Kazim, Abdul-Rahman, Houssaini, Jamal, Tappe, Dennis & Heo, Chong-Chin, 2022, An annotated checklist of sucking lice (Phthiraptera: Anoplura) from domestic and wild mammals in Malaysia, with lists of hosts and pathogens, pp. 301-336 in Zootaxa 5214 (3) on page 325, DOI: 10.11646/zootaxa.5214.3.1, http://zenodo.org/record/7389119
BindingDB Entry 50020620: Optimized M24B Aminopeptidase Inhibitors for CARD8 Inflammasome Activation.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Xaa-Pro aminopeptidase 1 and Xaa-Pro dipeptidase, Memorial Sloan Kettering Cancer Center, Affinity

description: Small molecule binding data for protein Xaa-Pro aminopeptidase 1 and Xaa-Pro dipeptidase, Uniprot P12955 and Q9NQW7
BindingDB Entry 50020618: Selective Covalent Targeting of Pyruvate Kinase M2 Using Arsenous Warheads.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Pyruvate kinase PKM, Chinese Academy of Sciences, Affinity

description: Small molecule binding data for protein Pyruvate kinase PKM, Uniprot P14618
BindingDB Entry 50020617: Application of Novel Degraders Employing Autophagy for Expediting Medicinal Research.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Nicotinamide phosphoribosyltransferase, Chengdu University of Traditional Chinese Medicine, Affinity

description: Small molecule binding data for protein Nicotinamide phosphoribosyltransferase, Uniprot P43490
Sus scrofa Linnaeus 1758
Creators: name: Kazim, Abdul-Rahman
name: Houssaini, Jamal
name: Tappe, Dennis
name: Heo, Chong-Chin
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Artiodactyla
Suidae
Sus
Sus scrofa

description: Sus scrofa Linnaeus, 1758 Wild boar—Babi hutan
Haematopinus suis (Linnaeus, 1758)
description: Published as part of Kazim, Abdul-Rahman, Houssaini, Jamal, Tappe, Dennis & Heo, Chong-Chin, 2022, An annotated checklist of sucking lice (Phthiraptera: Anoplura) from domestic and wild mammals in Malaysia, with lists of hosts and pathogens, pp. 301-336 in Zootaxa 5214 (3) on page 325, DOI: 10.11646/zootaxa.5214.3.1, http://zenodo.org/record/7389119
BindingDB Entry 50020616: Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Cyclin-dependent kinase 2, University of Minnesota, Affinity

description: Small molecule binding data for protein Cyclin-dependent kinase 2, Uniprot P24941
Felis catus Linnaeus 1758
Creators: name: Kazim, Abdul-Rahman
name: Houssaini, Jamal
name: Tappe, Dennis
name: Heo, Chong-Chin
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Carnivora
Felidae
Felis
Felis catus

description: Felis catus Linnaeus, 1758 Domestic cat—Kucing
* Linognathus setosus (von Olfers, 1816)
description: Published as part of Kazim, Abdul-Rahman, Houssaini, Jamal, Tappe, Dennis & Heo, Chong-Chin, 2022, An annotated checklist of sucking lice (Phthiraptera: Anoplura) from domestic and wild mammals in Malaysia, with lists of hosts and pathogens, pp. 301-336 in Zootaxa 5214 (3) on page 325, DOI: 10.11646/zootaxa.5214.3.1, http://zenodo.org/record/7389119
BindingDB Entry 50020612: Recent Advances on Small-Molecule Bromodomain-Containing Histone Acetyltransferase Inhibitors.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Bromodomain and PHD finger-containing protein 3, Bromodomain-containing protein 2, Bromodomain-containing protein 4, Bromodomain-containing protein 7, Bromodomain-containing protein 9, CREB-binding protein, Histone acetyltransferase KAT2B, Histone acetyltransferase p300, Peregrin, Platelet-derived growth factor receptor alpha/beta, Serine/threonine-protein kinase ATR, and Transcription initiation factor TFIID subunit 1, Sichuan University, Affinity

description: Small molecule binding data for protein Bromodomain and PHD finger-containing protein 3, Bromodomain-containing protein 2, Bromodomain-containing protein 4, Bromodomain-containing protein 7, Bromodomain-containing protein 9, CREB-binding protein, Histone acetyltransferase KAT2B, Histone acetyltransferase p300, Peregrin, Platelet-derived growth factor receptor alpha/beta, Serine/threonine-protein kinase ATR, and Transcription initiation factor TFIID subunit 1, Uniprot O60885, P05622, P21675, P25440, P26618, P55201, Q09472, Q13535, Q92793, Q92831, Q9H8M2, Q9NPI1, and Q9ULD4
Obama nungara Carbayo, Alvarez-Presas, Jones & Riutort 2016
Creators: name: Suárez, Daniel
name: Pedrianes, Juan Ramón
name: Andújar, Carmelo
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Platyhelminthes
Tricladida
Geoplanidae
Obama
Obama nungara

description: Obama nungara Carbayo, Álvarez-Presas, Jones & Riutort, 2016
Material examined: PORTUGAL: Madeira: Ribeiro Bonito, 32.810373°N, - 16.937081°W, 795 m, 7.IX.2019, 1 ex. (GenBank accession number OM 019327), C. Andújar leg., found in a laurel forest soil sample. SPAIN: Canary Islands, Gran Canaria: Tenteniguada, 27.975184°N, - 15.529326°W, 1010 m, 14.IV.2019, 5 exx. (GenBank accession number OM 019325 & OM 019326), D. Suárez leg., found under a plastic mulch of a strawberry (Fragaria sp.) plantation.
This species is native to South America (Argentina and Brazil), and has been introduced in several countries of Europe (England, Spain, France, Belgium, Italy, Ireland, and Portugal, including Madeira, and Azores) (Carbayo et al. 2016; Justine et al. 2020; Lago-Barcia et al. 2020; Mori et al. 2022). Here it is reported for the first time for the Canary Islands. The presence of this species in Madeira was published in Justine et al. (2020) as a personal communication without data regarding locality or collection date. Thus, this record confirms the presence of the species in Madeira. Sequences from Madeira and the Canary Islands match to the ‘network 3’ of Lago-Barcia et al. (2019), which includes sequences from Spain, Portugal, and Argentina, as well as sequences from Italy (Mori et al. 2022), France and Belgium (Justine et al. 2020) (Figure 1A).
description: Published as part of Suárez, Daniel, Pedrianes, Juan Ramón & Andújar, Carmelo, 2022, DNA barcoding reveals new records of invasive terrestrial flatworms (Platyhelminthes, Tricladida, Geoplanidae) in the Macaronesian region, pp. 447-450 in Zootaxa 5129 (3) on page 448, DOI: 10.11646/zootaxa.5129.3.9, http://zenodo.org/record/6501321
Suncus murinus
Creators: name: Kazim, Abdul-Rahman
name: Houssaini, Jamal
name: Tappe, Dennis
name: Heo, Chong-Chin
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Soricomorpha
Soricidae
Suncus
Suncus murinus

description: Suncus murinus (Linnaeus, 1766) Asian house shrew—Cencurut rumah
Polyplax reclinata (Nitzsch, 1864)
description: Published as part of Kazim, Abdul-Rahman, Houssaini, Jamal, Tappe, Dennis & Heo, Chong-Chin, 2022, An annotated checklist of sucking lice (Phthiraptera: Anoplura) from domestic and wild mammals in Malaysia, with lists of hosts and pathogens, pp. 301-336 in Zootaxa 5214 (3) on page 325, DOI: 10.11646/zootaxa.5214.3.1, http://zenodo.org/record/7389119
BindingDB Entry 50020611: Structure-Directed Discovery of Potent Soluble Epoxide Hydrolase Inhibitors for the Treatment of Inflammatory Diseases.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Bifunctional epoxide hydrolase 2, Shenyang Pharmaceutical University, Affinity

description: Small molecule binding data for protein Bifunctional epoxide hydrolase 2, Uniprot P34913 and P34914
BindingDB Entry 50020610: Dopamine D
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 2C, D(1A) dopamine receptor, D(2) dopamine receptor, D(3) dopamine receptor, and D(4) dopamine receptor, National Institute On Drug Abuse?Intramural Research Program, Affinity

description: Small molecule binding data for protein 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 2C, D(1A) dopamine receptor, D(2) dopamine receptor, D(3) dopamine receptor, and D(4) dopamine receptor, Uniprot A0A024R3C5, P08908, P14416, P21728, P21917, P28223, P28335, P35462, and P41595
Caenoplana coerulea Moseley 1877
Creators: name: Suárez, Daniel
name: Pedrianes, Juan Ramón
name: Andújar, Carmelo
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Platyhelminthes
Tricladida
Geoplanidae
Caenoplana
Caenoplana coerulea

description: Caenoplana coerulea Moseley, 1877
Material examined: PORTUGAL: Madeira: Faial, 32.793609°N, - 16.848819°W, 20 m, 7.IX.2019, 1 ex. (GenBank accession number OM 019322), C. Andújar leg., found in a soil sample near a beach.
This species is native to Australia but has been introduced to New Zealand, the United States, Argentina, the United Kingdom, France, and Spain, including the Balearic and Canary archipelagos (Álvarez-Presas et al. 2014; Breugelmans et al. 2012; Luis-Negrete et al. 2011; Suárez et al. 2018). Here we provide the first record from Madeira. Álvarez-Presas et al. (2014) found that C. coerulea was subdivided in three main clades. Our specimen from Madeira matches to a clade including sequences from Australia, Catalonia and the Canary Islands (Spain) (Figure 1B).
description: Published as part of Suárez, Daniel, Pedrianes, Juan Ramón & Andújar, Carmelo, 2022, DNA barcoding reveals new records of invasive terrestrial flatworms (Platyhelminthes, Tricladida, Geoplanidae) in the Macaronesian region, pp. 447-450 in Zootaxa 5129 (3) on page 448, DOI: 10.11646/zootaxa.5129.3.9, http://zenodo.org/record/6501321
Endeavouria septemlineata
Creators: name: Suárez, Daniel
name: Pedrianes, Juan Ramón
name: Andújar, Carmelo
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Platyhelminthes
Tricladida
Geoplanidae
Endeavouria
Endeavouria septemlineata

description: Endeavouria septemlineata (Hyman, 1939)
Material examined: PORTUGAL: Madeira: Funduras, 32.748989°N, - 16.806857°W, 740 m, 7.IX.2019, 1 ex. (GenBank accession number OM 019324), C. Andújar leg., found in a laurel forest soil sample. SPAIN: Canary Islands, Tenerife: El Bailadero, 28.551440°N, - 16.194065°W, 405 m, 10.I.2022, 10 ex., D. Suárez leg., found in a pitfall trap laid on the laurel forest; Carretera El Bailadero, 28.543226ºN, - 16.219725ºW, 740 m, 10.I.2022, 8 exx., C. Andújar leg., found in pitfall traps laid on a laurel forest. La Palma: Camino El Brezal, 28.649035ºN, - 17.778564ºW, 305 m, 26.VIII.2009, 1 ex., J. Pedrianes obs.; 6.V.2012, 1 ex., J. Pedrianes obs.; Camino La Justa, 28.689071ºN, - 17.943783ºW, 650 m, 4.VII.2019, 6 exx. (GenBank accession number OM 019323), J. Matos leg., found in roots of beetroot (Beta vulgaris); Barranco de Juan Mayor, 28.688932ºN, - 17.776292ºW, 180 m, 1 ex., C. Lozano obs., found in a strawberry (Fragaria sp.) plantation.
Originally known from Hawaii, E. septemlineata is also present in the Cook Islands, Brazil, Tahiti, and Italy (Justine et al. 2018a; Mori et al. 2022). This constitutes the first report for both Madeira and the Canary Islands. Sequences matched identically to all available sequences on GenBank (Figure 1C).
It is noteworthy that some specimens of O. nungara and E. septemlineata were found in well-preserved humid laurel forest. Recently, Lago-Barcia et al. (2020) found O. nungara in Azores in a natural area comprised of low scrubland and prairies. Caenoplana coerulea in Madeira was found in a scrubland near a beach. Although in the Canary Islands this species is predominantly found in anthropic areas, it has also been found in a subterranean ecosystem (Suárez et al. 2018). Overall, this suggests that contrary to continental settings where land planarians are typically found in anthropic ecosystems, such as gardens or greenhouses (Álvarez-Presas et al. 2014), in oceanic island systems invasive flatworms have the potential to extend their ranges into natural areas, thus posing a threat to endemic invertebrate fauna.
description: Published as part of Suárez, Daniel, Pedrianes, Juan Ramón & Andújar, Carmelo, 2022, DNA barcoding reveals new records of invasive terrestrial flatworms (Platyhelminthes, Tricladida, Geoplanidae) in the Macaronesian region, pp. 447-450 in Zootaxa 5129 (3) on page 449, DOI: 10.11646/zootaxa.5129.3.9, http://zenodo.org/record/6501321
Leptotrombidium (Leptotrombidium) laoense Stekolnikov 2013
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Trombiculidae
Leptotrombidium
Leptotrombidium laoense

description: Leptotrombidium (Leptotrombidium) laoense Stekolnikov, 2013:
ORI
Leptotrombidium laoense Stekolnikov, 2013, 2021
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 133, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510
BindingDB Entry 50020609: Visible-Light-Controlled Histone Deacetylase Inhibitors for Targeted Cancer Therapy.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Histone deacetylase 1, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Affinity

description: Small molecule binding data for protein Histone deacetylase 1, Uniprot Q13547
BindingDB Entry 50020608: Fragment-to-Lead Medicinal Chemistry Publications in 2021.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Adenosine receptor A1, Histone-lysine N-methyltransferase ASH1L, Oxidized purine nucleoside triphosphate hydrolase, Proto-oncogene tyrosine-protein kinase receptor Ret, and YEATS domain-containing protein 4, Astex Pharmaceuticals, Affinity

description: Small molecule binding data for protein Adenosine receptor A1, Histone-lysine N-methyltransferase ASH1L, Oxidized purine nucleoside triphosphate hydrolase, Proto-oncogene tyrosine-protein kinase receptor Ret, and YEATS domain-containing protein 4, Uniprot O95619, P07949, P30542, P36639, and Q9NR48
Playbook: a planning, scheduling and execution tool for flagship missions and small projects alike
Creators: name: Marquez, Jessica
name: Deliz, Ivy
Publisher: name: Zenodo
Year: 2024

description: Playbook, a software tool designed and developed at NASA Ames Research Center, enables mission operations planning, scheduling, and execution for NASA’s human and robotic missions. This web-accessible, user-friendly, and collaborative tool enables users to focus on mission planning and execution by scheduling and viewing activity parameters, tracking execution status, modeling constraints and resources, and enabling communications latency for missions simulating conditions beyond low Earth orbit. 

Playbook has supported a variety of analog missions, technology demonstrations, and field tests funded by different directorates. For the Science Mission Directorate, two spaceflight programs have leveraged Playbook. Mars2020 Mission utilizes COCPIT, a customized version of Playbook, to enable specific workflows and integration within their Ground Data System. The Commercial Lunar Payload Services (CLPS) program employs Playbook to plan activities for NASA payloads on their missions. 

The team iterated upon the software for over a decade, evolving it into a flagship-level planning and execution platform. However, it is challenging to secure consistent funding to further advance Playbook’s capabilities and provide it as a service to projects with limited budgets. The team provides the development, deployment, and maintenance of the tool, removing the technical barriers and enabling users to focus on achieving their scientific objectives.
Cynocephalus variegatus Sunda
Creators: name: Kazim, Abdul-Rahman
name: Houssaini, Jamal
name: Tappe, Dennis
name: Heo, Chong-Chin
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Dermoptera
Cynocephalidae
Cynocephalus
Cynocephalus variegatus

description: Cynocephalus variegatus (Audebert, 1799) Sunda flying lemur—Kubong
Hamophthirius galeopitheci Mjöberg, 1925
description: Published as part of Kazim, Abdul-Rahman, Houssaini, Jamal, Tappe, Dennis & Heo, Chong-Chin, 2022, An annotated checklist of sucking lice (Phthiraptera: Anoplura) from domestic and wild mammals in Malaysia, with lists of hosts and pathogens, pp. 301-336 in Zootaxa 5214 (3) on page 326, DOI: 10.11646/zootaxa.5214.3.1, http://zenodo.org/record/7389119
BindingDB Entry 50020605: Discovery of dual-action phenolic 4-arylidene-isoquinolinones with antioxidant and α-glucosidase inhibition activities.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Platelet-derived growth factor receptor alpha/beta, National Autonomous University of Mexico, Affinity

description: Small molecule binding data for protein Platelet-derived growth factor receptor alpha/beta, Uniprot P05622 and P26618
Additional file 15: of Community characteristics of the gut microbiomes of competitive cyclists
Creators: name: Petersen, Lauren
name: Bautista, Eddy
name: Nguyen, Hoan
name: Hanson, Blake
name: Chen, Lei
name: Lek, Sai
name: Sodergren, Erica
name: Weinstock, George
Publisher: name: Figshare
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Materials and methods used for additional files. (DOCX 122Â kb)
Berylmys bowersi
Creators: name: Kazim, Abdul-Rahman
name: Houssaini, Jamal
name: Tappe, Dennis
name: Heo, Chong-Chin
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Muridae
Berylmys
Berylmys bowersi

description: Berylmys bowersi (Anderson, 1879) Bowser’s white-toothed rat—Tikus bulu kasar
Hoplopleura diaphora Johnson, 1964
Hoplopleura kitti Kim, 1968
description: Published as part of Kazim, Abdul-Rahman, Houssaini, Jamal, Tappe, Dennis & Heo, Chong-Chin, 2022, An annotated checklist of sucking lice (Phthiraptera: Anoplura) from domestic and wild mammals in Malaysia, with lists of hosts and pathogens, pp. 301-336 in Zootaxa 5214 (3) on page 326, DOI: 10.11646/zootaxa.5214.3.1, http://zenodo.org/record/7389119
BindingDB Entry 50020604: Discovery of 5-trifluoromethyl-2-aminopyrimidine derivatives as potent dual inhibitors of FLT3 and CHK1.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Aurora kinase A, Cyclin-dependent kinase 2, Epidermal growth factor receptor, Interleukin-1 receptor-associated kinase 4, Mast/stem cell growth factor receptor Kit, Platelet-derived growth factor receptor alpha/beta, Receptor-type tyrosine-protein kinase FLT3, Serine/threonine-protein kinase 17B, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase pim-1, Tyrosine-protein kinase BTK, and Tyrosine-protein kinase JAK3, Zhejiang University, Affinity

description: Small molecule binding data for protein Aurora kinase A, Cyclin-dependent kinase 2, Epidermal growth factor receptor, Interleukin-1 receptor-associated kinase 4, Mast/stem cell growth factor receptor Kit, Platelet-derived growth factor receptor alpha/beta, Receptor-type tyrosine-protein kinase FLT3, Serine/threonine-protein kinase 17B, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase pim-1, Tyrosine-protein kinase BTK, and Tyrosine-protein kinase JAK3, Uniprot O14757, O14965, O94768, P00533, P05622, P10721, P11309, P24941, P26618, P36888, P52333, Q06187, Q69FE3, and Q9NWZ3
Frankfurter Journal 1848,213(3.Aug.)[3.Beil.]; 1848
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2019

description: Verantw. Red.: G. Strehlke, L. Metzger, anfangs: J.L. Heller
BindingDB Entry 50020603: Small molecule WDR5 inhibitors down-regulate lncRNA expression.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: WD repeat-containing protein 5, Max Planck Institute of Molecular Physiology, Affinity

description: Small molecule binding data for protein WD repeat-containing protein 5, Uniprot P61964
Leopoldamys edwardsi
Creators: name: Kazim, Abdul-Rahman
name: Houssaini, Jamal
name: Tappe, Dennis
name: Heo, Chong-Chin
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Muridae
Leopoldamys
Leopoldamys edwardsi

description: Leopoldamys edwardsi (Thomas, 1882) Edward’s long-tailed giant rat—Tikus bukit besar
Polyplax spinulosa (Burmeister, 1838)
description: Published as part of Kazim, Abdul-Rahman, Houssaini, Jamal, Tappe, Dennis & Heo, Chong-Chin, 2022, An annotated checklist of sucking lice (Phthiraptera: Anoplura) from domestic and wild mammals in Malaysia, with lists of hosts and pathogens, pp. 301-336 in Zootaxa 5214 (3) on page 326, DOI: 10.11646/zootaxa.5214.3.1, http://zenodo.org/record/7389119
Lesteva
Creators: name: Shavrin, Alexey V.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Lesteva

description: Key to the Lesteva species of Taiwan
1 Larger, 3.90–4.60 mm. Forebody reddish brown to dark brown; elytra without maculae or spots, unicolorous. Parameres distinctly shorter than apex of aedeagus (Watanabe 2005: Figs. 2–4) ................ L. chujoi Watanabe, 2005
- Smaller species. Elytra with maculae or round spots. Parameres longer .................................................................... 2
2 Pronotum strongly transverse. Body reddish brown; each elytron with yellow brown macula, extending from shoulders towards suture. Punctation of head and pronotum very dense, small. Habitus as in Fig. 1. Body length: 3.35– 3.70 mm. Aedeagus small, moderately wide (Figs. 3–4)................................................................... L. smetanai sp. n.
- Pronotum moderately narrow. Body dark brown to black; each elytron with yellow roundish spot in middle. Punctation of head and pronotum sparser and larger. Habitus as in Fig. 2. Body length: 3.70–3.80 mm. Aedeagus very long, narrow (Figs. 5–6)................................................................................................ L. rufopunctata taiwanica subsp. n.
description: Published as part of Shavrin, Alexey V., 2015, New species and subspecies of the genus Lesteva Latreille, 1797 (Coleoptera: Staphylinidae: Omaliinae) from Taiwan, pp. 333-338 in Zootaxa 4032 (3) on page 337, DOI: 10.11646/zootaxa.4032.3.10, http://zenodo.org/record/245587
BindingDB Entry 50020601: Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Phosphatidylinositol 4-kinase alpha and Phosphatidylinositol 4-kinase beta, Korea Research Institute of Chemical Technology, Affinity

description: Small molecule binding data for protein Phosphatidylinositol 4-kinase alpha and Phosphatidylinositol 4-kinase beta, Uniprot P42356 and Q9UBF8
BindingDB Entry 50020600: Kinase inhibitor macrocycles: a perspective on limiting conformational flexibility when targeting the kinome with small molecules.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: ALK tyrosine kinase receptor, Cyclin-dependent kinase 2, High affinity nerve growth factor receptor, NT-3 growth factor receptor, Non-receptor tyrosine-protein kinase TYK2, Receptor-type tyrosine-protein kinase FLT3, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, and Tyrosine-protein kinase JAK3, University of Arkansas, Affinity

description: Small molecule binding data for protein ALK tyrosine kinase receptor, Cyclin-dependent kinase 2, High affinity nerve growth factor receptor, NT-3 growth factor receptor, Non-receptor tyrosine-protein kinase TYK2, Receptor-type tyrosine-protein kinase FLT3, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, and Tyrosine-protein kinase JAK3, Uniprot O60674, P04629, P23458, P24941, P29597, P36888, P52333, Q16288, and Q9UM73
BindingDB Entry 50020599: Role of heterocycles in inhibition of VEGFR-2 - a recent update (2019-2022).
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Hepatocyte growth factor receptor, Platelet-derived growth factor receptor beta, and Vascular endothelial growth factor receptor 2, Srmpp, Affinity

description: Small molecule binding data for protein Hepatocyte growth factor receptor, Platelet-derived growth factor receptor beta, and Vascular endothelial growth factor receptor 2, Uniprot A0A024R759, P08581, P09619, and P35968
BindingDB Entry 50020598: Design, synthesis and biological evaluation of novel morpholinopyrimidine-5-carbonitrile derivatives as dual PI3K/mTOR inhibitors.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, and Serine/threonine-protein kinase mTOR, Health Affairs Directorate - Giza, Affinity

description: Small molecule binding data for protein Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, and Serine/threonine-protein kinase mTOR, Uniprot O00329, P42336, P42338, and P42345
Leopoldamys sabanus
Creators: name: Kazim, Abdul-Rahman
name: Houssaini, Jamal
name: Tappe, Dennis
name: Heo, Chong-Chin
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Muridae
Leopoldamys
Leopoldamys sabanus

description: Leopoldamys sabanus (Thomas, 1887) Long-tailed giant rat—Tikus mondok ekor panjang
Hoplopleura malaysiana Ferris, 1921
Polyplax insulsa Ferris, 1923
Polyplax spinulosa (Burmeister, 1838)
description: Published as part of Kazim, Abdul-Rahman, Houssaini, Jamal, Tappe, Dennis & Heo, Chong-Chin, 2022, An annotated checklist of sucking lice (Phthiraptera: Anoplura) from domestic and wild mammals in Malaysia, with lists of hosts and pathogens, pp. 301-336 in Zootaxa 5214 (3) on page 326, DOI: 10.11646/zootaxa.5214.3.1, http://zenodo.org/record/7389119
BindingDB Entry 50020597: Consensus screening for a challenging target: the quest for P-glycoprotein inhibitors.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: ATP-dependent translocase ABCB1, The Scripps Research Institute, Affinity

description: Small molecule binding data for protein ATP-dependent translocase ABCB1, Uniprot P08183
BindingDB Entry 50020596: Discovery of Anti-Hypercholesterolemia Agents Targeting LXRα from Marine Microorganism-Derived Natural Products.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Oxysterols receptor LXR-alpha, Guangxi University of Chinese Medicine, Affinity

description: Small molecule binding data for protein Oxysterols receptor LXR-alpha, Uniprot Q13133
Maxomys alticola Mountain
Creators: name: Kazim, Abdul-Rahman
name: Houssaini, Jamal
name: Tappe, Dennis
name: Heo, Chong-Chin
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Muridae
Maxomys
Maxomys alticola

description: Maxomys alticola (Thomas, 1888) Mountain spiny rat—Tikus duri bukit
Hoplopleura pectinata (Cummings, 1913)
description: Published as part of Kazim, Abdul-Rahman, Houssaini, Jamal, Tappe, Dennis & Heo, Chong-Chin, 2022, An annotated checklist of sucking lice (Phthiraptera: Anoplura) from domestic and wild mammals in Malaysia, with lists of hosts and pathogens, pp. 301-336 in Zootaxa 5214 (3) on page 326, DOI: 10.11646/zootaxa.5214.3.1, http://zenodo.org/record/7389119
Additional file 13: of Community characteristics of the gut microbiomes of competitive cyclists
Creators: name: Petersen, Lauren
name: Bautista, Eddy
name: Nguyen, Hoan
name: Hanson, Blake
name: Chen, Lei
name: Lek, Sai
name: Sodergren, Erica
name: Weinstock, George
Publisher: name: Figshare
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Table showing abundance of M. smithii based on mWGS sequencing, RNA-Seq, and qPCR. (DOCX 99Â kb)
KREDIT VA BOSHQA QARZLAR BILAN BOGʼLIQ OPERATSIYALARLAR AUDITINI REJALASHTIRISH
Creators: name: Yunusov, Abduvoxid
Publisher: name: Zenodo
Year: 2024

description: Kredit va boshqa qarzlar bilan bogʼliq operatsiyalar auditini takomillashtirish bo’yicha ilmiy maqolada auditorlik tekshiruvini jarayonida rejalashtirishni samaradorligini oshirish uchun qo’shimcha auditorlik amallarini rejaga kiritish (kredit va boshqa qarzlar bo’yicha tuzilgan shartnomalarni hamda boshqa hujjatlarni o’rganish); kreditor tashkilotlari tomonidan beriladigan pul mablag’larni ularning ruxsatisiz pul o’tkazmalarini amalga oshirimaslik; kredit va qarzlarni maqsadli ishlatilishini kuzatib borish va natijalarini rasmiylashtirish; ichki nazorat tizimi bo’yicha yo’riqnomalarini takomillashtirish orqali kredit va qarzlar bo’yicha risklarni kamaytirish (ichki auditor tekshiriruvdan o’tkazish) keltirilgan.
BindingDB Entry 50020593: Recent advances of phenotypic screening strategies in the application of anti-influenza virus drug discovery.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Epidermal growth factor receptor, Neuraminidase, and Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta, Shandong University, Affinity

description: Small molecule binding data for protein Epidermal growth factor receptor, Neuraminidase, and Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta, Uniprot B4URF0, O00750, P00533, and Q2LFS1
Maxomys ochraceiventer
Creators: name: Kazim, Abdul-Rahman
name: Houssaini, Jamal
name: Tappe, Dennis
name: Heo, Chong-Chin
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Muridae
Maxomys
Maxomys ochraceiventer

description: Maxomys ochraceiventer (Thomas, 1894) Chestnut-bellied spiny rat—Tikus duri dada perang
Ancistroplax nasuta Johnson, 1964
description: Published as part of Kazim, Abdul-Rahman, Houssaini, Jamal, Tappe, Dennis & Heo, Chong-Chin, 2022, An annotated checklist of sucking lice (Phthiraptera: Anoplura) from domestic and wild mammals in Malaysia, with lists of hosts and pathogens, pp. 301-336 in Zootaxa 5214 (3) on page 326, DOI: 10.11646/zootaxa.5214.3.1, http://zenodo.org/record/7389119
Leptotrombidium (Leptotrombidium) laojunshanense Yu, Yang and Gong 1986
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Trombiculidae
Leptotrombidium
Leptotrombidium laojunshanense

description: Leptotrombidium (Leptotrombidium) laojunshanense Yu, Yang and Gong, 1986:
PAL
Leptotrombidium laojunshanense, Stekolnikov 2013 [pentagonum group]
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 133, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510
BindingDB Entry 50020592: Discovery of Novel PD-L1 Inhibitors That Induce the Dimerization, Internalization, and Degradation of PD-L1 Based on the Fragment Coupling Strategy.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Platelet-derived growth factor receptor alpha/beta and Programmed cell death 1 ligand 1, China Pharmaceutical University, Affinity

description: Small molecule binding data for protein Platelet-derived growth factor receptor alpha/beta and Programmed cell death 1 ligand 1, Uniprot P05622, P26618, Q9EP73, and Q9NZQ7
BindingDB Entry 50020591: Discovery of a Hidden Pocket beneath the NES Groove by Novel Noncovalent CRM1 Inhibitors.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Exportin-1, Sichuan University, Affinity

description: Small molecule binding data for protein Exportin-1, Uniprot O14980
Maxomys rajah Rajah
Creators: name: Kazim, Abdul-Rahman
name: Houssaini, Jamal
name: Tappe, Dennis
name: Heo, Chong-Chin
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Muridae
Maxomys
Maxomys rajah

description: Maxomys rajah (Thomas, 1894) Rajah spiny rat—Tikus duri hitam pudar
Hoplopleura pectinata (Cummings, 1913)
description: Published as part of Kazim, Abdul-Rahman, Houssaini, Jamal, Tappe, Dennis & Heo, Chong-Chin, 2022, An annotated checklist of sucking lice (Phthiraptera: Anoplura) from domestic and wild mammals in Malaysia, with lists of hosts and pathogens, pp. 301-336 in Zootaxa 5214 (3) on page 326, DOI: 10.11646/zootaxa.5214.3.1, http://zenodo.org/record/7389119
BindingDB Entry 50020590: Synthesis, Optimization, and Structure-Activity Relationships of Nicotinamide Phosphoribosyltransferase (NAMPT) Positive Allosteric Modulators (N-PAMs).
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Nicotinamide phosphoribosyltransferase, University of Arizona, Affinity

description: Small molecule binding data for protein Nicotinamide phosphoribosyltransferase, Uniprot P43490
Getting Started Guides: An Introduction
Creators: name: Project, Embedding
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 350702
subject: Corporate social responsibility
classificationCode: 410103
subject: Human impacts of climate change and human adaptation

description: Whether you are developing your first strategy for sustainability or refining an existing one, our Getting Started Guides can help provide clarity on the work ahead. Getting Started Guides: An Introduction shares our overall approach and clarifies the value of setting a clear strategy anchored in your company’s most material issues. It also explains key concepts that underpin the work outlined within each guide, including building an understanding of system thresholds and process-based interim targets.
BindingDB Entry 50020589: One-Pot Synthesis of Cereblon Proteolysis Targeting Chimeras via Photoinduced C(sp
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Protein cereblon, Boehringer Ingelheim Rcv, Affinity

description: Small molecule binding data for protein Protein cereblon, Uniprot Q96SW2
POSTER-Interacciones Climáticas: El ENOS en la Orinoquía y el Pacífico colombiano
Creators: name: Alvarez Moreno, Laura Valeria
name: Sarmiento Bastidas, Laura Camila
name: Torres Ramirez, Sara Valentina
name: Lizcano Sandoval, Victor Augusto
Publisher: name: Zenodo
Year: 2024

description: La variabilidad climática, particularmente en lo que respecta a las precipitaciones, juega un papel fundamental en la configuración de los ecosistemas y las actividades humanas en las regiones de Colombia. El fenómeno El Niño-Oscilación del Sur (ENOS) es uno de los principales moduladores de esta variabilidad, afectando de manera significativa las dinámicas climáticas en las regiones Pacífica y Orinoquía. Comprender cómo estas fluctuaciones impactan el clima local es esencial para generar diagnósticos más precisos y desarrollar herramientas que faciliten la toma de decisiones, con el fin de optimizar la gestión de recursos y mitigar los riesgos asociados al cambio climático.

El estudio analizó la variabilidad espacial y temporal de las precipitaciones asociadas al fenómeno ENOS en las regiones Pacífica y Orinoquía de Colombia. Utilizando datos de precipitación mensual de 1993-2023 y el Índice Oceánico de El Niño (ONI), se empleó correlación cruzada para evaluar la relación entre ambos factores. En la región Pacífica, los eventos de El Niño disminuyen las lluvias, siendo más notorio en Chocó, mientras que La Niña genera aumentos previos. En Orinoquía, los efectos son moderados, con patrones diferenciados en Meta, donde las lluvias aumentan antes de La Niña y disminuyen tras El Niño. Aunque ENOS altera los patrones, no elimina la estacionalidad climática, destacando la importancia de entender los ciclos anuales para anticipar excesos o déficits de lluvia según promedios históricos.

Palabras Clave: Índice Oceánico de El Niño (ONI), Correlación Cruzada, Precipitaciones ENOS
Updates in microsurgical technique for cleft palate reconstruction
Creators: name: Daniela Fernanda Carpio Escobar M.D.
name: Rodrigo Rueda De León Serna M.D.
name: Irving Arturo Castillo Pérez M.D.
name: Alexis Andrei Granados Flores  M.D.
name: Daniel Fernando Narvaez Hernandez M.D.
name: Jose Roberto Gonzalez Soto M.D.
name: Daniela Medina Correa M.D.
name: María Idalia Padilla Salazar M.D.
name: José Fernando Montiel Castañeda M.D.
name: Karla Patricia Montoya Moreno M.D.
Publisher: name: Zenodo
Year: 2024

description: Background:

The soft palate is a crucial structure that plays a vital role in maintaining the airway open, facilitating swallowing, and enabling speech. Excisional surgery that disrupts the functional architecture of the soft palate leads to considerable morbidity, and neither prosthetic nor flap reconstructions can adequately restore the intrinsic velar musculature. The primary objectives in treating oral malignancies that impact the soft palate are to attain oncological control and minimize the occurrence of complications and undesired consequences.

In the present age of microsurgical practice, teams are striving to not only accomplish oncological excision and successful flap procedures but also to enhance functional results. In this case, a suprafascial ALT flap was surgically created to provide extra volume and optimize the functional benefit of the remaining velar muscles. The treatment method depends on the dimensions of the defect and the anatomical components removed. For full-thickness injuries, direct repair is recommended, while for full-thickness, "near-total to total," greater than 70%, a nonanatomic reconstruction is carried out, and a fascial sling is included to constrict the velopharynx.

Tips for addressing velopharyngeal constriction include using a two-layer closure technique, using a fascial sling, positioning the skin vessel/perforator, incorporating the vastus lateralis muscle, maintaining a minimum distance between the point of entrance into the muscle and the point where the perforator branches off, and verifying the vitality of the muscle prior to completing the closure.

In conclusion, employing an anterolateral thigh (ALT) free flap technique for palate reconstruction achieves favorable functional results with minimal complications at the donor site.

 

Keywords: Microsurgery, cleft palate, free flap
Maxomys whiteheadi
Creators: name: Kazim, Abdul-Rahman
name: Houssaini, Jamal
name: Tappe, Dennis
name: Heo, Chong-Chin
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Muridae
Maxomys
Maxomys whiteheadi

description: Maxomys whiteheadi (Thomas, 1894) Whitehead’s spiny rat—Tikus bangkung
Hoplopleura pectinata (Cummings, 1913)
Polyplax spinulosa (Burmeister, 1838)
description: Published as part of Kazim, Abdul-Rahman, Houssaini, Jamal, Tappe, Dennis & Heo, Chong-Chin, 2022, An annotated checklist of sucking lice (Phthiraptera: Anoplura) from domestic and wild mammals in Malaysia, with lists of hosts and pathogens, pp. 301-336 in Zootaxa 5214 (3) on page 326, DOI: 10.11646/zootaxa.5214.3.1, http://zenodo.org/record/7389119
Additional file 8: of Complete plastome sequencing of both living species of Circaeasteraceae (Ranunculales) reveals unusual rearrangements and the loss of the ndh gene family
Creators: name: Yanxia Sun
name: Moore, Michael
name: Lin, Nan
name: Adelalu, Kole
name: Aiping Meng
name: Shuguang Jian
name: Linsen Yang
name: Jianqiang Li
name: Hengchang Wang
Publisher: name: Figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 60506 Virology

description: List of taxa included in phylogenetic analyses. (DOC 67 kb)
BindingDB Entry 50020587: Small Molecule Inhibitors Targeting the "Undruggable" Survivin: The Past, Present, and Future from a Medicinal Chemist's Perspective.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Baculoviral IAP repeat-containing protein 5, Probable ATP-dependent RNA helicase DDX5, Receptor-interacting serine/threonine-protein kinase 2, and Transcription factor Sp1, University of Toledo College of Medicine and Life Sciences, Affinity

description: Small molecule binding data for protein Baculoviral IAP repeat-containing protein 5, Probable ATP-dependent RNA helicase DDX5, Receptor-interacting serine/threonine-protein kinase 2, and Transcription factor Sp1, Uniprot O15392, O43353, P08047, and P17844