cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Infrared attenuated total reflection spectroscopic surface analysis of bovine‐tail intervertebral discs after UV‐light‐activated riboflavin‐induced collagen cross‐linking
Creators: name: Vasilikos, Ioannis
name: Haas, Julian
name: Teixeira, Graciosa Q.
name: Nothelfer, Julia
name: Neidlinger‐Wilke, Cornelia
name: Wilke, Hans‐Joachim
name: Seitz, Andreas
name: Vavvas, Demetrios G.
name: Zentner, Josef
name: Beck, Jürgen
name: Hubbe, Ulrich
name: Mizaikoff, Boris
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: attenuated total reflection
subject: collagen cross‐linking
subject: IR‐ATR
subject: IVD
subject: riboflavin‐induced cross‐linking
subject: spinal surgery
subject: UVA‐CXL
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health
subject: Infrared spectroscopy
subject: Intervertebral disk
subject: ATR-Technik
subject: Infrarotspektroskopie

description: The tensile strength of the intervertebral disc (IVD) is mainly maintained by collagen cross-links. Loss of collagen cross-linking combined with other age-related degenerative processes contributes to tissue weakening, biomechanical failure, disc herniation and pain. Exogenous collagen cross-linking has been identified as an effective therapeutic approach for restoring IVD tensile strength. The current state-of-the-art method to assess the extent of collagen cross-linking in tissues requires destructive procedures and high-performance liquid chromatography. In this study, we investigated the utility of infrared attenuated total reflection (IR-ATR) spectroscopy as a nondestructive analytical strategy to rapidly evaluate the extent of UV-light-activated riboflavin (B2)-induced collagen cross-linking in bovine IVD samples. Thirty-five fresh bovine-tail IVD samples were equally divided into five treatment groups: (a) untreated, (b) cell culture medium Dulbecco's Modified Eagle's Medium only, (c) B2 only, (d) UV-light only and (e) UV-light-B2. A total of 674 measurements have been acquired, and were analyzed via partial least squares discriminant analysis. This classification scheme unambiguously identified individual classes with a sensitivity >91% and specificity >92%. The obtained results demonstrate that IR-ATR spectroscopy reliably differentiates between different treatment categories, and promises an excellent tool for potential in vivo, nondestructive and real-time assessment of exogenous IVD cross-linking.
sj-docx-1-sgo-10.1177_21582440231218229 – Supplemental material for The Relationship Between Administrative Empowerment and Organizational Commitment: The Mediating Role of Job Satisfaction Amongst Academic Staff in Higher Education
Creators: name: Harb, Husameddin Khalil
name: Eyupoglu, Serife Zihni
name: Tashtoush, Laith
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Communication and Media Studies not elsewhere classified
subject: Criminology not elsewhere classified
subject: Education
subject: Psychology not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-sgo-10.1177_21582440231218229 for The Relationship Between Administrative Empowerment and Organizational Commitment: The Mediating Role of Job Satisfaction Amongst Academic Staff in Higher Education by Husameddin Khalil Harb, Serife Zihni Eyupoglu and Laith Tashtoush in SAGE Open
Safety of vedolizumab in the treatment of pregnant women with inflammatory bowel disease: a targeted literature review
Creators: name: Terjung, Birgit
name: Schmelz, Renate
name: Ehehalt, Robert
name: Klaus, Jochen
name: Knop, Jana
name: Schwind, Sabine
name: Wilke, Thomas
name: Stallmach, Andreas
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Vedolizumab
subject: Anti-TNF
subject: DDC 610 / Medicine & health
subject: Inflammatory bowel diseases
subject: Pregnancy
subject: Crohn disease
subject: Colitis, Ulcerative
subject: Drug therapy
subject: Treatment outcome
subject: Chronische Darmentzündung
subject: Colitis ulcerosa
subject: Crohn-Krankheit
subject: Schwangerschaft
subject: Pharmakotherapie
subject: Therapieerfolg

description: Crohn’s disease (CD) and ulcerative colitis (UC) commonly affect women in their childbearing years. Vedolizumab (VDZ) is approved for treatment of moderate-to-severe CD and UC, but there is a knowledge gap regarding its use during pregnancy. This targeted literature review describes available evidence on safety of VDZ in pregnant patients in order to offer physicians a detailed and balanced view on persistent data during their decision-making process for an individualized treatment concept.
sj-docx-1-tar-10.1177_17534666231214040 – Supplemental material for Impact of the COVID-19 pandemic on adherence to positive airway pressure treatment in patients with obstructive sleep apnea: systematic review and meta-analysis
Creators: name: Jo, Soomin
name: Cho, Jaeyoung
Publisher: name: SAGE Journals
Year: 2023
Subjects: Aged Health Care
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Respiratory Diseases

description: Supplemental material, sj-docx-1-tar-10.1177_17534666231214040 for Impact of the COVID-19 pandemic on adherence to positive airway pressure treatment in patients with obstructive sleep apnea: systematic review and meta-analysis by Soomin Jo and Jaeyoung Cho in Therapeutic Advances in Respiratory Disease
title: Faithful representations of minimal degree for Lie algebras with an abelian radical
Creators: name: Moens, Wolfgang Alexander
Year: 2009

description: In dieser Dissertation untersuchen wir die sogenannte $\mu$-Invariante von Lie Algebren. F\"ur eine endlich-dimensionale Lie Algebra $\mathfrak{g}$ ist sie die minimale Dimension eines treuen $\mathfrak{g}$-Moduls. Es ist bereits nicht-trivial zu zeigen, da\ss\ diese Invariante Werte in den nat\"urlichen Zahlen annimmt, d.h., da\ss\ jede endlich-dimensionale Lie Algebra eine endlich-dimensionale treue Darstellung besitzt. Das wurde urspr\"unglich von Ado und Iwasawa bewiesen, und ist ein fundamentales Resultat. Es hat eine lange Geschichte. In dieser Arbeit geht es um eine Verfeinerung des Ado-Iwasawa-Theorems, und zwar in folgender Hinsicht:\\[1cm] {\it Sei $\mathfrak{g}$ eine endlich-dimensionale Lie algebra. Berechne $\mu(\Lg)$ und finde einen treuen Modul dieser Dimension. Beschreibe die Eigenschaften treuer Moduln minimaler Dimension. Berechne obere und untere Schranken f\"ur $\mu(\mathfrak{g})$ als Funktion anderer Invarianten. }\\[1cm] Im allgemeinen kann man keine explizite Formel f\"ur $\mu(\mathfrak{g})$ erwarten, insbesondere nicht f\"ur nilpotente Lie Algebren. Die Frage ist daher, ob man f\"ur reduktive bzw. halbeinfache Lie Algebren $\mu(\mathfrak{g})$ bestimmen kann. Tats\"achlich gelingt dies f\"ur den Fall da\ss\ $\mathfrak{g}$ abelsch, einfach, halbeinfach oder reduktiv ist. Der Beweis dazu ist im wesentlichen kombinatorischer Natur und verwendet klassiche Resultate der Darstellungstheorie f\"ur reduktive Lie-Algebren. Allgemeiner untersuchen wir die $\mu$-Invariante auch f\"ur Lie Algebren deren aufl\"osbares Radikal abelsch ist. Wir betrachten weitere Invarianten, die mit der $\mu$-Invariante zusammenh\"angen. Abschliessend werden dazu einige spezielle Familien von solchen Lie Algebren im Detail betrachtet.
Reactions of deoxyribonucleotide bases with sulfooxymethyl or halomethyl polycyclic aromatic hydrocarbons induce unwinding of DNA supercoils
Creators: name: Lehner, Andreas F.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Torsional stress in double-stranded DNA enables and regulates facets of chromosomal metabolism, replication, and transcription and requires regulatory enzymatic systems including topoisomerases and histone methyltransferases. As such, this machinery may be subject to deleterious effects from reactive mutagens, including ones from carcinogenic polycyclic aromatic hydrocarbon (PAH) adduct formation with DNA. Supercoiled plasmid DNA was investigated for its torsional responses to adducts formed in vitro from PAH benzylic carbocation reactive intermediates created spontaneously by release of leaving groups. PAH sulfate esters were found to (1) unwind DNA in a concentration dependent manner, and (2) provide maximum unwinding in a pattern consistent with known carcinogenicities of the parent PAHs, that is, 6-methylbenzo[a]pyrene > 7,12-methylbenz[a]anthracene > 3-methylcholanthrene > 9-methylanthracene > 7-methylbenz[a]anthracene > 1-methylpyrene. Supercoil unwinding was demonstrated to be dependent on the presence of sulfate or chloride leaving groups such that reactive carbocations were generated in situ by hydrolysis. In silico modeling of intercalative complex topology showed PAH benzylic carbocation reactive functional groups in alignment with target nucleophiles on guanine bases in a 5’-dCdG-3’ pocket in agreement with known formation of nucleotide adducts. Inhibitory or modulatory effects on PAH-induced supercoil unwinding were seen with ascorbic acid and an experimental antineoplastic agent Antineoplaston A10 in agreement with their known anticarcinogenic properties. In summary, the reactive PAH intermediates studied here undoubtedly participate in well-known mutational mechanisms such as frameshifts and apurinic site generation. However, they are also capable of random disruption of chromosomal supercoiling in a manner consistent with the known carcinogenicities of the parent compounds, and this mechanism may represent an additional detrimental motif worthy of further study for a more complete understanding of chemical carcinogenicity.
Preservation of adrenoceptor and endothelin receptor mediated vasoconstriction after cold storage of explanted blood vessels for ex-vivo analyses
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Endothelin receptor
subject: Adrenoceptor
subject: Organ bath
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health
subject: Saphenous vein
subject: Endothelins; Receptors
subject: Adrenoceptors
subject: Cold storage
subject: Receptors, Endothelin
subject: Receptors, Adrenergic
subject: Saphenous Vein
subject: Adrenergic receptors
subject: Endothelin
subject: Rezeptor
subject: Kühllagerung
subject: Beinvene

description: Purpose: Cold storage of blood vessels is a concern in bypass surgery and in ex vivo pharmacological experiments. We compared adrenoceptor and endothelin receptor-mediated vasoconstriction as well as endothelium-dependent vasodilation before and after 20 h storage in commercial and custom-made vessel storage solutions. Methods: Saphenous veins harvested during coronary artery bypass surgery were analyzed by isometric force measurements in organ baths before and after cold storage for 20 h in HEPES-supplemented Dulbecco's modified Eagle's medium (HDMEM), HEPES-supplemented Krebs-Henseleit solution (HKH), or TiProtec solution. Contractile responses to potassium chloride (KCl), norepinephrine (NE), and endothelin-1 (ET-1) as well as vasodilator responses to acetylcholine (ACh) were evaluated. Results: Storage in HDMEM diminished KCl induced contractile forces to 71% (p=0.002) and NE induced contractions to 80% (p=0.037) with no significant changes with the other solutions. NE induced contractions normalized to KCl were not affected by storage. NE EC50 values were slightly lower (7.1E-8 vs. 7.5E-8, p=0.019) after storage in HKH with no changes after storage in the other solutions. Endothelium-dependent responses to ACh were not affected by storage. ET-1 induced contractions were attenuated after storage in HDMEM (77%, p=0.002), HKH (75%, p=0.020), and TiProtec (73%, p=0.010) with no changes in the KCl-normalized constrictions. ET-1 EC50 values were not affected by storage. Conclusion: Changes in contractility after storage likely reflect malnutrition during cold storage with no specific attenuation of adrenoceptor or endothelin-receptor mediated signal transduction. HKH or TiProtec are equally suitable cold storage solutions for preserving blood vessel function for ex-vivo measurements.
IVM QUANTUM REBIRTH THEORY
Creators: name: McGrane, Ian
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 490203
subject: Mathematical aspects of classical mechanics, quantum mechanics and quantum information theory

description: The IVM Quantum Rebirth Theory proposes a fundamental restructuring of the universe’s origins, dimensional architecture, and the role of consciousness in reality. It introduces a cyclical Big Bang model, integrates white holes and black holes as a cosmic equilibrium, and suggests that 4D consciousness exists beyond the constraints of time. The theory also explores the mathematical geometry of ancient structures (such as the Pyramids) as potential reflections of hidden universal truths. The theory aims to redefine how we perceive existence, proposing that the universe is in a constant state of quantum rebirth—a cycle of expansion, collapse, and renewal, governed by deep, fundamental equations that bridge physics and consciousness.
Correspondence: Daylighting: Why infra-red should be explored
Creators: name: Veto, Peter
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: non-visual effects
subject: DDC 620 / Engineering & allied operations
subject: Daylighting
subject: Infrared technology
subject: Infrared radiation
subject: Daylight
subject: Tageslichtsystem
subject: Infrarottechnik
subject: Infrarot
subject: Tageslicht

description: (Due to the brevity and nature of the paper, no abstract is provided.)
Patterns in Language and Law
Creators: name: Solan, Lawrence M.
Publisher: name: International Language and Law Association (ILLA)
Year: 2017
Subjects: subject: corpus, ordinary meaning, rule, pattern, standard, legal linguistics, courts, US judiciary
subject: Social and Behavioral Sciences: Linguistics: Applied Linguistics; Law: Jurisprudence; Law: Legal Writing and Research

description: Our language faculty is rule-like in some ways, pattern-like in others, as Steven Pinker (1999) has shown. Much of syntax is describable a set of rules, whereas the range of meanings attributed to a word is best described in terms of patterns. Laws are typically written as rules, but they are written in words, many of which display pattern-like arrays of usage. Legal systems default to an expression’s “ordinary meaning,” requiring estimates of patterns of usage. Recently, advances in corpus linguistics have been adduced by judges and legal scholars in this regard. Furthermore, open-textured legal terms, including the word “pattern” itself, are by their nature more describable in terms of patterns of their application than in terms of hard-and-fast rules. Apart from linguistic issues in legal interpretation, legal systems value coherence, requiring that like things be treated alike, often focusing on patterns of how laws are applied. At times, however, these patterns uncover biases in a law’s application. This article attempts to describe how this duality in both linguistic description law interact with each other.

Cite as: Solan, JLL 6 (2017), 46–66, DOI: 10.14762/jll.2017.046
description: International Journal of Language & Law (JLL), Vol 6: The Fabric of Language and Law
Additional file 3 of Vascular covered stent and video-assisted thoracoscopic surgery for Aortoesophageal fistula caused by esophageal fishbone: a case report
Creators: name: Chen, Jianfeng
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Cancer

description: Supplementary Material 3
SHARE: a transparent mechanism for reliable broadcast delivery in CAN
Creators: name: Livani, Mohammad Ali
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: DDC 004 / Data processing & computer science
subject: Controller area network
subject: CAN-Bus

description: The paper presents a mechanism called Shadow Retransmitter (SHARE) which ensures the reliable transmission of broadcast messages in a CAN bus. Due to its full transparency, SHARE can be added to existing application systems to provide high reliability. Keywords: Reliable Broadcast, Real-time communication, fault-tolerance, CAN.
title: Tod- und Jenseitsvorstellungen in wichtigen hinduistischen Traditionen
Creators: name: Eberhardt, Helmut
Year: 2009

description: In der vedischen Epoche existierten in Indien noch keine Reinkar-nationsvorstellungen. Man hatte ein lineares Zeitverständnis und man glaubte an ein irdisches Leben bis zum Tod und danach an ein ewiges glückliches Leben in der Welt der seligen Väter. Ethische Überlegungen spielten in den damaligen Jenseitsvorstellungen höchstens ansatzweise eine Rolle, weshalb man auch an kein jenseitiges Gericht zum Zweck einer Tatvergeltung glaubte. In der spätvedischen Zeit kam es aber zu einer entscheidenden Veränderung. In den jüngeren Upanishaden (ab etwa 900 v. Chr.) begann sich ein zyklisches Denken herauszubilden und der Glaube an einen jenseitigen Wiedertod entstand. Gleichzeitig fand ethisches Denken Eingang in die hinduistischen Nachtodvorstellungen. Aus den beiden Elementen entwickelte sich die Karma-Samsara-Lehre, die auch heute noch zentraler Glaubensinhalt aller wichtigen hinduistischen Traditionen ist. Diese Lehre besagt, dass Getanes abgegolten werden muss und sich nicht folgenlos verlieren darf, wenn ein Mensch stirbt. Daher muss es eine Wiedergeburt geben, weil nur in einer neuen Existenz den Postulaten der Gerechtigkeit, Kontinuität und Kausalität entsprochen werden kann. Für seine Taten wird ein Verstorbener zunächst in einer Himmelswelt belohnt oder in einer Höllenwelt bestraft, bevor er eine Wiedergeburt erfährt, die ebenfalls durch seine Taten in früheren Existenzen bestimmt wird. Diese Abläufe bedürfen keiner göttlichen Intervention sondern werden durch das universelle Karma-Gesetz bestimmt. Dem ewigen Kreislauf der Wieder-geburten, der als leidvoll empfunden wird, kann man aber durch die Erlö-sung entfliehen. In allen hinduistischen Traditionen werden Wege aufgezeigt, die zur Erlösung führen.
Agomelatine ameliorates doxorubicin-induced cortical and hippocampal brain injury via inhibition of TNF-alpha/NF-kB pathway
Creators: name: Savran, Mehtap
name: Asci, Sanem
name: Gulle, Kanat
name: Aslankoc, Rahime
name: Asci, Halil
name: Karakuyu, Nasif Fatih
name: Erzurumlu, Yalçın
name: Kaynak, Mine
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Side effects of doxorubicin (DOX) are mainly due to oxidative stress, with the involvement of inflammatory and apoptotic mechanisms. Agomelatine (AGO) is a melatonin receptor agonist with antioxidant, anti-inflammatory, and anti-apoptotic features. This study aimed to evaluate the effects of AGO with different doses on DOX-induced neurotoxicity. Rats were divided into four groups as control, DOX (40 mg/kg, intraperitoneal single dose), DOX + AGO20 (20 mg/kg AGO oral gavage for 14 days), and DOX + AGO40 (40 mg/kg AGO oral gavage for 14 days). On day 14, brain tissues were collected for biochemical, histopathological, and genetic examinations. DOX significantly increased malondialdehyde and decreased superoxide dismutase and catalase (CAT) levels. CAT levels were significantly increased only in the DOX + AGO40 group compared to the DOX group (p = 0.040) while other changes in oxidant and antioxidant indicators were insignificant. DOX-induced significant increases in TNF-alpha and NF-κB were reversed following both low and high-dose AGO administration in a dose-dependent manner (p < 0.001 for both doses). Cellular shrinkage, pycnotic change, and vacuolization in apoptotic bodies were apparent in the cortical and hippocampal areas of DOX-treated samples. Both doses of AGO alleviated these histopathological changes (p = 0.01 for AGO20 and p = 0.05 for AGO40). Significantly increased apoptosis shown with caspase-3 immunostaining in the DOX group was alleviated following AGO administration, with additional improvement after high-dose treatment (p < 0.01 for DOX compared to both AGO groups and p < 0.05 for AGO40 compared to AGO20). AGO can be protective against DOX-induced neurotoxicity by antioxidant, anti-inflammatory, and anti-apoptotic mechanisms in a dose-dependent manner.
Left ventricular strain analysis during submaximal semisupine bicycle exercise stress echocardiography in childhood cancer survivors
Creators: name: Scheidt, Fabian Von
name: Pleyer, Christine
name: Kiesler, Verena
name: Bride, Peter Michael
name: Bartholomä, Stephan Linus
name: Krämer, Johannes
name: Kaestner, Michael
name: Apitz, Christian
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Childhood cancer survivor
subject: 2D‐speckle‐tracking strain echocardiography
subject: Cardio‐oncology
subject: DDC 610 / Medicine & health
subject: Cancer survivors
subject: Neoplasms
subject: Cardiology
subject: Echocardiography, Stress
subject: Onkologie
subject: Kardiologie
subject: Krebs
subject: Überlebender
subject: Stressechokardiographie

description: Background Childhood cancer survivors (CCSs) show relevant cardiac morbidity and mortality throughout life. Early detection is key for optimal support of patients at risk. The aim of this study was to evaluate 2‐dimensional speckle‐tracking echocardiography strain analysis during semisupine exercise stress in CCSs for detection of subclinical left ventricular dysfunction after cancer treatment. Methods and Results Seventy‐seven CCSs ≥1‐year postchemotherapy were prospectively examined at rest, low, and submaximal stress level and compared with a cohort of healthy adolescents and young adults (n=50). Global longitudinal strain (GLS), short axis circumferential strain, and corresponding strain rates were analyzed using vendor‐independent software. CCSs at median 7.8 years postchemotherapy showed comparable left ventricular GLS, circumferential strain, and strain rate values at all stress stages to healthy controls. Yet, prevalence of abnormal GLS (defined as <2 SD of controls reference) in CCSs was 1.3% at rest, 2.7% at low, and 8.6% at submaximal stress. In CCSs, relative change of circumferential strain from rest to submaximal stress was lower than in healthy controls, median 16.9 (interquartile range [IQR], 3.4; 28.8) % versus 23.3 (IQR, 11.3; 33.3) %, P=0.03, most apparent in the subgroups of CCSs after high‐dose anthracycline treatment and cancer diagnosis before the age of 5 years. Conclusions In this prospective 2‐dimensional speckle tracking echocardiography strain study, prevalence of abnormal left ventricular GLS increased with stress level reflecting impaired cardiac adaptation to exercise stress in some CCSs. However, relatively early after last chemotherapy, this did not result in significant differences of mean GLS‐, circumferential strain‐, and strain rate values between CCSs and controls at any stress level.
Additional file 1 of Reproducible isolation of bovine mammary macrophages for analysis of host pathogen interactions
Creators: name: Tomes, Abbie
name: Archer, Nathan
name: Leigh, James
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 1
Automated analysis of cerebrospinal fluid cells using commercially available blood cell analysis devices—a critical appraisal
Creators: name: Wick, Manfred
name: Gross, Catharina
name: Tumani, Hayrettin
name: Wildemann, Brigitte
name: Stangel, Martin
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: cell differentiation
subject: automation
subject: CSF diagnostics
subject: DDC 610 / Medicine & health
subject: Cerebrospinal fluid
subject: Cell differentiation
subject: Liquor cerebrospinalis
subject: Zelldifferenzierung

description: The analysis of cells in the cerebrospinal fluid (CSF) is a routine procedure that is usually performed manually using the Fuchs–Rosenthal chamber and cell microscopy for cell counting and differentiation. In order to reduce the requirement for manual assessment, automated analyses by devices mainly used for blood cell analysis have been also used for CSF samples. Here, we summarize the current state of investigations using these automated devices and critically review their limitations. Despite technical improvements, the lower limit for reliable leukocyte counts in the CSF is still at approximately 20 cells/µL, to be validated depending on the device. Since the critical range for clinical decisions is in the range of 5–30 cells/µL this implies that cell numbers < 30/µL require a manual confirmation. Moreover, the lower limit of reliable erythrocyte detection by automated devices is at approximately 1000/µL. However, even low erythrocyte numbers may be of clinical importance. In contrast, heavily hemorrhagic samples from neurosurgery may be counted automatically at an acceptable precision more quickly. Finally, cell differentiation by automated devices provides only a rough orientation for lymphocytes, granulocytes and monocytes. Other diagnostically important cell types such as tumor cells, siderophages, blasts and others are not reliably detected. Thus, although the automation may give a gross estimate sufficient for the emergency room situation, each CSF requires a manual microscopy for cytological evaluation for the final report. In conclusion, although automated analysis of CSF cells may provide a first orientation of the cell profile in an individual sample, an additional manual cell count and a microscopic cytology are still required and represent the gold standard.
Identification and tissue-specific characterization of novel SHOX-regulated genes in zebrafish highlights SOX family members among other genes
Creators: name: Hoffmann, Sandra
name: Roeth, Ralph
name: Diebold, Sabrina
name: Gogel, Jasmin
name: Hassel, David
name: Just, Steffen
name: Rappold, Gudrun A.
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: short stature
subject: skeletal dysplasia
subject: pectoral fins
subject: SHOX deficiency
subject: skeletal disease associations
subject: DDC 610 / Medicine & health
subject: Osteochondrodysplasias; Genetics
subject: Zebrafish
subject: Dysplasie
subject: Skelett
subject: Zebrabärbling
subject: Genetik

description: SHOX deficiency causes a spectrum of clinical phenotypes related to skeletal dysplasia and short stature, including Léri-Weill dyschondrosteosis, Langer mesomelic dysplasia, Turner syndrome, and idiopathic short stature. SHOX controls chondrocyte proliferation and differentiation, bone maturation, and cellular growth arrest and apoptosis via transcriptional regulation of its direct target genes NPPB, FGFR3, and CTGF. However, our understanding of SHOX-related pathways is still incomplete. To elucidate the underlying molecular mechanisms and to better understand the broad phenotypic spectrum of SHOX deficiency, we aimed to identify novel SHOX targets. We analyzed differentially expressed genes in SHOX-overexpressing human fibroblasts (NHDF), and confirmed the known SHOX target genes NPPB and FGFR among the most strongly regulated genes, together with 143 novel candidates. Altogether, 23 genes were selected for further validation, first by whole-body characterization in developing shox-deficient zebrafish embryos, followed by tissue-specific expression analysis in three shox-expressing zebrafish tissues: head (including brain, pharyngeal arches, eye, and olfactory epithelium), heart, and pectoral fins. Most genes were physiologically relevant in the pectoral fins, while only few genes were also significantly regulated in head and heart tissue. Interestingly, multiple sox family members (sox5, sox6, sox8, and sox18) were significantly dysregulated in shox-deficient pectoral fins together with other genes (nppa, nppc, cdkn1a, cdkn1ca, cyp26b1, and cy26c1), highlighting an important role for these genes in shox-related growth disorders. Network-based analysis integrating data from the Ingenuity pathways revealed that most of these genes act in a common network. Our results provide novel insights into the genetic pathways and molecular events leading to the clinical manifestation of SHOX deficiency.
Adjacent Habitat Influence on Stink Bug (Hemiptera: Pentatomidae) Densities and the Associated Damage at Field Corn and Soybean Edges
Creators: name: Venugopal, P. Dilip
name: Coffey, Peter L.
name: Dively, Galen P.
name: Lamp, William O.
Publisher: name: Digital Repository at the University of Maryland
Year: 2014

description: The local dispersal of polyphagous, mobile insects within agricultural systems impacts pest management. In the mid-
Atlantic region of the United States, stink bugs, especially the invasive Halyomorpha halys (Stal 1855), contribute to economic losses across a range of cropping systems. Here, we characterized the density of stink bugs along the field edges of field corn and soybean at different study sites. Specifically, we examined the influence of adjacent managed and natural habitats on the density of stink bugs in corn and soybean fields at different distances along transects from the field edge. We also quantified damage to corn grain, and to soybean pods and seeds, and measured yield in relation to the observed stink bug densities at different distances from field edge. Highest density of stink bugs was limited to the edge of both corn and soybean fields. Fields adjacent to wooded, crop and building habitats harbored higher densities of stink bugs than those adjacent to open habitats. Damage to corn kernels and to soybean pods and seeds increased with stink bug density in plots and was highest at the field edges. Stink bug density was also negatively associated with yield per plant in soybean. The spatial pattern of stink bugs in both corn and soybeans, with significant edge effects, suggests the use of pest management strategies for crop placement in the landscape, as well as spatially targeted pest suppression within fields.
title: Familiäre Strukturen in Fernsehserien als Spannungsfeld zwischen privatem und öffentlichem Raum
Creators: name: Pulverer, Sonja
Year: 2009

description: Die vorliegende Arbeit mit dem Thema "„Familiäre Strukturen in Fernsehserien als Spannungsfeld zwischen privatem und öffentlichem Raum – Darstellung, Wertevermittlung und potentiellem Nutzen am Beispiel von Desperate Housewives und Gilmore Girls“ setzt sich mit der Darstellung des im privaten angesiedelten Bereichs der Familie im öffentlichen Forum des Mediums und im Speziellen in der Familienserie auseinander. Hierbei werden sowohl spezifische familiäre Konstruktionsmuster der gewählten Unterhaltungsprodukte sichtbar gemacht als auch in einen gewissen Vergleich zu Gegebenheiten einer realen Gesellschaft gesetzt. Es werden in diesem Zuge auch spezielle Rollenzuschreibungen getätigt, die nicht nur Stereotypisierungen und Vorurteile sichtbar machen bzw. umgekehrt, sondern vor allem auch auf Innovationen in den Verteilungen der einzelnen Aufgaben und Beziehungen untereinander hinweisen. Es wird auf der Basis einer Filmanalyse gearbeitet. Darüber hinaus werden wichtige Werte und Umgangsformen beschrieben, die diesen familiären Kontext skizzieren, und im Zuge einer Rezeption vermittelt werden. Sie komplimentieren das komplexe Umfeld des sozialen Gefüges Familie und geben Aufschluss über Tendenzen, die hierbei zu finden sind. Es kann dadurch auch ein Bild davon gewonnen werden, wie einzelne Altersgruppen innerhalb eines familiären Bundes medial wahrgenommen werden bzw. welche Missstände im Sinne solcher Darstellungen angesprochen werden. Letztendlich werden in prägnanter Form potentielle Nutzungsmotive von Familienserien präsentiert, die sich aus den Ergebnissen der empirischen Studie ergeben haben. Da die Verbindung der Medien und des Alltags in einer hohen positiven Korrelation zueinander steht, zeigt sich eine Beschäftigung mit diesem Themenbereich als relevant, da Dokumente über die Situationen in einer Gesellschaft geschaffen werden können.
The determinants of B cell receptor signaling as prototype molecular biomarkers of leukemia
Creators: name: Nicolò, Antonella
name: Linder, Alexandra Theresa
name: Jumaa, Hassan
name: Maity, Palash Chandra
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: BCR signaling
subject: CLL
subject: transformation
subject: immunoglobulin genes
subject: DDC 610 / Medicine & health
subject: Leukemia, Lymphocytic, Chronic, B-Cell
subject: Biomarkers
subject: Receptors, Antigen, B-cell
subject: Signal transduction
subject: Chronisch-lymphatische Leukämie
subject: B-Zell-Lymphom
subject: Biomarker

description: Advanced genome-wide association studies (GWAS) identified several transforming mutations in susceptible loci which are recognized as valuable prognostic markers in chronic lymphocytic leukemia (CLL) and B cell lymphoma (BCL). Alongside, robust genetic manipulations facilitated the generation of preclinical mouse models to validate mutations associated with poor prognosis and refractory B cell malignancies. Taken together, these studies identified new prognostic markers that could achieve characteristics of precision biomarkers for molecular diagnosis. On the contrary, the idea of augmented B cell antigen receptor (BCR) signaling as a transforming cue has somewhat receded despite the efficacy of Btk and Syk inhibitors. Recent studies from several research groups pointed out that acquired mutations in BCR components serve as faithful biomarkers, which become important for precision diagnostics and therapy, due to their relevant role in augmented BCR signaling and CLL pathogenesis. For example, we showed that expression of a single point mutated immunoglobulin light chain (LC) recombined through the variable gene segment IGLV3-21, named IGLV3-21R110, marks severe CLL cases. In this perspective, we summarize the molecular mechanisms fine-tuning B cell transformation, focusing on immunoglobulin point mutations and recurrent mutations in tumor suppressors. We present a stochastic model for gain-of-autonomous BCR signaling and subsequent neoplastic transformation. Of note, additional mutational analyses on immunoglobulin heavy chain (HC) derived from non-subset #2 CLL IGLV3-21R110 cases endorses our perspective. Altogether, we propose a model of malignant transformation in which the augmented BCR signaling creates a conducive platform for the appearance of transforming mutations.
Kin recognition in Drosophila: Rearing environment and relatedness can modulate gut microbiota and cuticular hydrocarbon odour profiles
Creators: name: García-Roa, Roberto
name: Domínguez-Santos, Rebeca
name: Pérez-Brocal, Vicente
name: Moya, Andrés
name: Latorre, Amparo
name: Carazo, Pau
Publisher: name: Zenodo
Year: 2022
Subjects: kin recognition
gut microbiota
Drosophila
Sexual conflict
chemical communication

description: From inbreeding avoidance to kin-selected cooperation, social behaviours are frequently reliant on kin recognition. However, kin recognition mechanisms are costly to evolve and currently not very well understood. Recent evidence suggests that, by altering their host's odour, gut and other host-associated microorganisms may provide a promising avenue for understanding kin recognition. In Drosophila melanogaster, kin recognition can mediate mate choice, sexual conflict and larval competition/cooperation, underscoring its important functional role. As is commonly the case, kin recognition in this species depends on both familiarity (i.e. shared rearing environment) and relatedness, and seems to rely mainly on body odours determined by cuticular hydrocarbons. Here, we investigated the degree to which larval rearing environment and relatedness (full-sibs vs. unrelated) determine co-variation between gut microbiota and cuticular hydrocarbons in D. melanogaster. We found that rearing environment strongly determined both microbiota and cuticular hydrocarbon composition, but that these effects were independent from each other. In contrast, relatedness did not influence microbiota composition, but had a strong influence on microbiota diversity, which in turn covaried significantly with cuticular hydrocarbon composition. Our results show that, in D. melanogaster, odours may convey information about both familiarity and relatedness via an interaction between: a) direct effects of the rearing environment on cuticular hydrocarbons and b) indirect effects of relatedness on cuticular hydrocarbons via gut microbiota diversity.
sj-pdf-1-smr-10.1177_00491241221122528 - Supplemental material for When Corporations Are People: Agent Talk and the Development of Organizational Actorhood, 1890–1934 *
Creators: name: Knight, Carly
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: Sociology

description: Supplemental material, sj-pdf-1-smr-10.1177_00491241221122528 for When Corporations Are People: Agent Talk and the Development of Organizational Actorhood, 1890–1934 * by Carly Knight in Sociological Methods & Research
Data from: Investigating human repeatability of a computer vision based task to identify meristems on a potato plant (Solanum tuberosum)
Creators: name: Harris, Edwin W.
name: Wager, Georgina A.
name: Butler, Matt
name: Mhango, Joseph M.
name: Monaghan, James M.
name: Green, Richard
Publisher: name: Zenodo
Year: 2022

description: Labelled training data in artificial intelligence (AI) is used to teach so-called 'supervised learning models'. However, such data may contain error or bias, which can impact model prediction accuracy. Thus, obtaining accurate training data is of high importance. In applications of AI, such as in classification and detection problems, raw training data is not always made available in published research. Likewise, the process of obtaining labelled data is not always documented well enough to enable reproducibility. This training data set captures a repeatability exercise in AI training data collection for a task that is difficult for humans to perform, delineating a bounding box in a two-dimensional image of a growing apical meristem in potato plants.
description: Contents •"SURNAME-stem-repeatability.zip" file contains folder with 30 images (10 unique) and bounding box data capture program "desktop_image_labeller.py" •"Tuber-stem-repeatability-instructions.docx"- instructions for observers taking part in the computer experiment •"further-information-distance-between-centres.docx" - details on the distance between centers measurement •"boxes.xlsx" - dataset explaining the information for each individual bounding box •"c_dist.xlsx" - dataset for the distance between the centers •"stems.xlsx" - dataset providing information on the number of stems identified per image • "repeatability-images-cheat-sheet.xlsx" – dataset providing a key to the unique images that have been replicated three times •"DRYAD-README.docx" - Use notes for repeatability data capture and associated documents Funding provided by: UK Research and Innovation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100014013
Award Number: 48752
description: Labelled image acquisition for repeatability was carried out by multiple observers, each identifying bounding boxes of the apical meristems on potato plants from images. Additionally, repeatability of bounding box identification was assessed by two separate methods, 'live labelling' (an expert was present indicating the centre of each meristem) and 'computer labelling' (the observer identified the bounding boxes without an expert supervising). Labelling was performed on n=10 unique images, a total of three times each (thus obtaining n = 30 bounding box sets per observer). In this experiment, ten observers completed the computer labelling task, and 3 observers also completed the live labelling task. Bounding box coordinates were captured via a graphical user interface program, adapted from the popular program Yolo_mark (https://github.com/weharris/yolo_mark_utility).
Datensatz Notaufnahme Version 2010
Creators: name: Kulla, Martin
name: Brammen, Dominik
name: Röhrig, Rainer
name: Lefering, Rolf
name: Helm, Matthias
name: Klinger, Sebastian
name: Gries, André
name: Bernhard, Michael
name: Baacke, Markus
name: Schöpfe, Timo
name: Ahlbrandt, Janko
name: Lampl, Lorenz
name: Ballaschk, Anna
name: Walcher, Felix
name: Marzi, Ingo
name: Gräff, Ingo
name: Petersen, Peter
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Bundeswehrkrankenhaus Ulm
subject: DDC 610 / Medicine & health
subject: Emergency department
subject: Ambulances
subject: Medical records
subject: Medical records system, computerized; Standards
subject: Ambulanz
subject: Notfallmedizin
subject: Medizin
subject: Dokumentation
subject: Datenbank
subject: Datensatz
subject: Register

description: Die vorliegenden Dokumente beschreiben die Version 2010 des Datensatz Notaufnahme. Die genannten Autoren stehen stellvertretend für die Mitglieder der Sektion Notaufnahmeprotokoll der DIVI. Weiterführende Informationen zu dem Datensatz erhalten Sie über den korrespondierenden Autor: Martin Kulla 2. Sprecher der Sektion Notaufnahmeprotokoll der DIVI Bundeswehrkrankenhaus Ulm Klinik für Anästhesiologie und Intensivmedizin Oberer Eselsberg 40 89081 Ulm E-Mail: martin.kulla@uni-ulm.de Der Datensatz Notaufnahme wird in: Kulla M, Röhrig R, Helm M, Bernhard M, Gries A, Lefering R, Walcher F, Sektion Notaufnahmeprotokoll der DIVI: [National data set “emergency department”. Development, structure and approval by the Deutsche Interdisziplinäre Vereinigung für Intensivmedizin und Notfallmedizin]. Anaesthesist 63: 243-255 (2014) und Kulla M, Baacke M, Schöpke T, Walcher F, Ballaschk A, Röhrig R, Ahlbrandt J, Helm M, Lampl L, Bernhard M, Brammen D: [Core Dataset “Emergency Department” of the German Interdisciplinary Association of Critical Care and Emergency Medicin (DIVI). Basis for healthcare research and quality control in emergency departments]. Notfall Rettungsmed 17: 671-681 (2014) näher beschrieben
Improved tensile ductility by severe plastic deformation for nano-structured metallic glass
Creators: name: Dong, Yue
name: Liu, Suya
name: Biskupek, Johannes
name: Cao, Qingping
name: Wang, Xiaodong
name: Jiang, Jian-Zhong
name: Wunderlich, Rainer
name: Fecht, Hans-Jörg
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: metallic glass
subject: nano-heterogeneous structure
subject: high-pressure torsion
subject: tensile plasticity
subject: DDC 620 / Engineering & allied operations
subject: Metallic glasses
subject: Röntgen-Kleinwinkelstreuung

description: The effect of severe plastic deformation by high-pressure torsion (HPT) on the structure and plastic tensile properties of two Zr-based bulk metallic glasses, Zr55.7Ni10Al7Cu19Co8.3 and Zr64Ni10Al7Cu19, was investigated. The compositions were chosen because, in TEM investigation, Zr55.7Ni10Al7Cu19Co8.3 exhibited nanoscale inhomogeneity, while Zr64Ni10Al7Cu19 appeared homogeneous on that length scale. The nanoscale inhomogeneity was expected to result in an increased plastic strain limit, as compared to the homogeneous material, which may be further increased by severe mechanical work. The as-cast materials exhibited 0.1% tensile plasticity for Zr64Ni10Al7Cu19 and Zr55.7Ni10Al7Cu19Co8.3. Following two rotations of HPT treatment, the tensile plastic strain was increased to 0.5% and 0.9%, respectively. Further testing was performed by X-ray diffraction and by differential scanning calorimetry. Following two rotations of HPT treatment, the initially fully amorphous Zr55.7Ni10Al7Cu19Co8.3 exhibited significantly increased free volume and a small volume fraction of nanocrystallites. A further increase in HPT rotation number did not result in an increase in plastic ductility of both alloys. Possible reasons for the different mechanical behavior of nanoscale heterogeneous Zr55.7Ni10Al7Cu19Co8.3 and homogeneous Zr64Ni10Al7Cu19 are presented.
Structure and decay of a proto-Y region in Tilapia, Oreochromis niloticus
Creators: name: Gammerdinger, William J.
name: Conte, Matthew A.
name: Acquah, Enoch A.
name: Roberts, Reade B.
name: Kocher, Thomas D.
Publisher: name: Digital Repository at the University of Maryland
Year: 2014

description: Sex-determination genes drive the evolution of adjacent chromosomal regions. Sexually antagonistic selection favors the accumulation of inversions that reduce recombination in regions adjacent to the sex-determination gene. Once established, the clonal inheritance of sex-linked inversions leads to the accumulation of deleterious alleles, repetitive elements and a gradual decay of sex-linked genes. This in turn creates selective pressures for the evolution of mechanisms that compensate for the unequal dosage of gene expression. Here we use whole genome sequencing to characterize the structure of a young sex chromosome and quantify sex-specific gene expression in the developing gonad. We found an 8.8 Mb block of strong differentiation between males and females that corresponds to the location of a previously mapped sex-determiner on linkage group 1 of Oreochromis niloticus. Putatively disruptive mutations are found in many of the genes within this region. We also found a significant female-bias in the expression of genes within the block of differentiation compared to those outside the block of differentiation. Eight candidate sex-determination genes were identified within this region. This study demonstrates a block of differentiation on linkage group 1, suggestive of an 8.8 Mb inversion encompassing the sex-determining locus. The enrichment of female-biased gene expression inside the proposed inversion suggests incomplete dosage compensation. This study helps establish a model for studying the early-to-intermediate stages of sex chromosome evolution.