cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Comparing Written Programs and Self-Reported Respiratory Protection Practices in Acute Care Hospitals
Creators: name: Sietsema, Margaret
name: Conroy, Lorraine M.
name: Brosseau, Lisa M.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 111714 Mental Health
subject: Science Policy
subject: Cancer
subject: Sociology
subject: FOS: Sociology
subject: Medicine

description: Airborne biological hazards in hospitals require the use of respiratory protection. A well-implemented respiratory protection program can protect health care workers from these exposures. This study examines the relationship between written respiratory programs and reported practices in health care settings. Twenty-eight hospitals in Illinois and Minnesota were recruited to a study of respiratory protection programs and practices in acute care settings. Interviews were conducted with hospital managers, unit managers, and health care workers from departments where respirators are commonly required. Each hospital's written respiratory protection program was scored for the 11 elements required by the Occupational Safety and Health Administration (OSHA), using a standardized tool, for a maximum possible score of 22 (2 pts. per element). Twenty interview questions associated with program practices were also scored by percent correct responses. Written program scores ranged from 2–17 with an average of 9.2. Hospital and unit managers scored on average 82% and 81%, respectively, when compared to the OSHA standard; health care workers scored significantly lower, 71% (p < 0.001). Minnesota written program scores were not significantly higher than Illinois hospitals (p = 0.16), while all Illinois survey respondents scored higher than those in Minnesota (p < 0.001). There was no trend between written programs and interview responses. Written respiratory protection programs in the study sites did not provide the level of detail required OSHA. Interview responses representing hospital practices surrounding respiratory protection indicated that hospitals were aware of and following regulatory guidelines.
Do indicators for the proportion of pharmaceutical spending alleviate the burden of medical expenditure? Evidence from provincial panel-data in China, 2010-2019
Creators: name: Yang, Tianan
name: Deng, Wenhao
name: Zhao, Weigang
name: Liu, Jiahao
name: Deng, Jianwei
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Biotechnology
Science Policy

description: The current study aims to empirically evaluate the direct relationship between the proportion of pharmaceutical spending and total medical expenditure in China in a recent decade period. A two-way fixed-effect model was established to estimate the relationship between the proportion of pharmaceutical spending and total medical expenditure using the balanced panel data for thirty provincial-level administrative regions in mainland China from 2010 to 2019. The proportion of pharmaceutical spending was significantly positively related to inpatient and outpatient expenditure, with coefficients of 0.30 (p = 0.014) and 0.58 (p = 0.002), respectively. This positive correlation was not significant in the eastern regions, likely due to the unexpected supply-side coping behaviors brought about by the compulsory control of the proportion of pharmaceutical spending. We investigated the improvement of service efficiency could significantly alleviate the burden of medical expenses. Our research provided empirical evidence for the necessity of using the proportion of pharmaceutical spending as a cost control indicator and showed the factors that may affect the amount of medical expenditure, emphasizing the significance of improving the efficiency of resource utilization to compensate for the unintended behaviors and effects caused by single index assessment.
Concise Synthesis of 1,3-Diacetoxy-2-[2′-(2′′,4′′-difluorophenyl)prop-2′-en-1′-yl]propane: An Intermediate for Posaconazole
Creators: name: Yunxiang Chen
name: Yangwei Huang
name: Xueqing Zhao
name: Zhongming Li
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Cell Biology
subject: Medicine
subject: Biochemistry
subject: Biophysics

description: A concise process of 1,3-diacetoxy-2-[2′-(2″,4″-difluorophenyl)prop-2′-en-1′-yl]propane has been developed. Diethyl malonate was C-alkylated with 2,3-dichloropropene and then the ester groups were reduced by LiAlH4, followed by acylation to provide 2-(2′-chloroprop-2′-en-1′-yl)-1,3-diacetoxypropane. The chloropropene was finally coupled with 2,4-difluorophenylmagnesium bromide and catalyzed by Fe(acac)3 to afford the title compound in good total yield.
Cambios en calidad de vida en Colombia durante 1997-2003 : otra aproximación
Creators: name: Forero Ramírez, Nohora Yulieth
name: Casas, Andres Fernando
name: Guerra Forero, José Alberto
name: Gamboa Niño, Luis Fernando
Publisher: name: Universidad del Rosario
Year: 2005

description: Este trabajo analiza, estática y dinámicamente, los cambios en las condiciones de vida de los hogares en Colombia entre los años 1997 y 2003. Se propone un indicador alternativo y se contrasta a nivel nacional, regional y de centro poblacional con el Índice de Calidad de Vida (ICV) convencional. El indicador alterno reconoce la importancia que tienen aspectos de salud y el tiempo gastado en desplazamiento. Estas variables adicionales reducen el impacto de los aspectos concernientes al capital físico y distancian aún más las condiciones de las zonas rurales frente a las urbanas. La importancia de profundizar en las políticas de salud en las zonas rurales y en políticas que permitan disminuir el tiempo gastado en desplazamiento para ambas zonas se torna evidente.
Affect theory and performance intention
Creators: name: Tait, Peta
Publisher: name: La Trobe
Year: 2022

description: This book ruminates on aspects of drama and theatrical
performance that attract attention, sustain interest and, on occasion, elicit
an emotionally felt response and even wonder.

Forms of Emotion explores emotion and its
diversity in drama, theatre and contemporary performance and the unifying and
separating tendencies of the emotions, emotional feeling, mood and affect.
Economic evaluation of reproductive carrier screening for recessive genetic conditions: a systematic review
Creators: name: Wang, Tianjiao
name: Bahrampour, Mina
name: Byrnes, Joshua
name: Scuffham, Paul
name: Kirk, Edwin
name: Downes, Martin
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Autosomal recessive (AR) and x-linked (XL) conditions are rare but collectively common which impact millions of people globally on morbidity, mortality and costs. Advanced medical technologies allow prospective parents to make informed reproductive decisions to avoid having affected children. Economic evaluations targeting on reproductive carrier screening (RCS) for AR and/or XL conditions have been conducted, but there has not been a systematic review in this area. A systematic search of economic evaluations for RCS was undertaken using the following databases – EMBASE, MEDLINE and SCOPUS. The search strategy was designed to capture full economic evaluations related to RCS since 1990. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) strategy. The included 23 studies adopted various types of methodologies to conduct economic evaluations. The majority of studies examined a single condition. The various clinical strategies and screened conditions caused the different cost-effectiveness conclusions in the published studies. Establishing a validated and practical clinical strategy of RCS and investigating the cost-effectiveness of multiple conditions in one economic evaluation are critical for implementing RCS in the future. Further economic evaluations are essential to provide evidence-based practice for decision-makers.
Bogotá a escala latinoamericana
Creators: name: Corredor Gómez, Eduardo
Publisher: name: Universidad del Rosario
Year: 2005

description: El presente documento aborda la situación de la ciudad de Bogotá en medio del proceso de globalización económica. Es un análisis comparado que tiene como objetivo mostrar el lugar que ocupa la capital colombiana en el nuevo escenario urbano dado por la globalización. Se pondrán a prueba las tesis propuestas por Saskia Sassen en su libro La ciudad global que se refieren a la concentración de la actividad económica contemporánea y al lugar clave para las finanzas.
Report on the Recent Prediction of a M 6.0 - 6.8 Earthquake in South Iran Made by Guangmeng Guo on 9 January, 2015: Prepared as an Advisory Document for Iranian officials
Creators: name: Helman, Daniel
Publisher: name: figshare
Year: 2015
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: This is a response to an earthquake prediction by Guangmeng Guo, who uses satellite data of cloud forms for his work. It includes an assessment of the prediction, and recommendations.
Las finanzas en la frontera del conocimiento
Creators: name: Olaya Pardo, Ana María
Publisher: name: Universidad del Rosario
Year: 2002

description: En los últimos treinta años las finanzas se convirtieron en una disciplina que ha sido objeto de estudio y transformaciones continuas. Su evolución y desarrollo ha sido sorprendente acercándose cada vez más a la frontera del conocimiento. A pesar de que sus primeros estudios fueron solamente prácticos y conceptuales, a partir de las década de los cincuenta surgió la teoría en las finanzas debido al reconocimiento de la incertidumbre y el riesgo tanto en los negocios como en la economía. En la búsqueda de una fundamentación teórica que permitiera predecir los comportamientos en el futuro de los asuntos financieros, se acudió a los conceptos desarrollados por la teoría económica. La complejidad y el surgimiento de nuevos cuestionamientos hicieron que la teoría financiera se sirviera tanto de la economía como de otras disciplinas como las matemáticas, estadística y econometría. En la actualidad es indispensable tener una completa formación en estas disciplinas para incursionar en el estudio de las finanzas.
Prosodies of affect and emotional climates
Creators: name: Tait, Peta
Publisher: name: La Trobe
Year: 2022

description: This book ruminates on aspects of drama and theatrical
performance that attract attention, sustain interest and, on occasion, elicit
an emotionally felt response and even wonder.

Forms of Emotion explores emotion and its
diversity in drama, theatre and contemporary performance and the unifying and
separating tendencies of the emotions, emotional feeling, mood and affect.
Assessment of the properties of the EQ-5D-5L in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
Creators: name: Afshari, Somayeh
name: Ameri, Hosein
name: Baharinya, Sajad
name: Arab-Zozani, Morteza
name: Mojahedian, Mohammad M
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Medicine
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: This study systematically reviews the validity, reliability, and responsiveness of the EQ-5D-5 L in studies of T2DM. Relevant articles were retrieved by searching four databases, namely, the Web of Science, Scopus, PubMed, and Cochrane Library up to November 2020 with English language. All stages of the review conducted by two authors and disagreements were solved by consultation with a third reviewer. Of the 1614 identified studies, 46 were remained for review. The EQ-5D-5 L mean scores ranged from 0.314 (0.4) (n = 141) for diabetic patients undergoing hemodialysis to 0.971 (0.082) (n = 56) for diabetic patient without retinopathy. Mean EQ-5D-5 L scores in men (0.847) were higher those in women (0.747). Construct validity and reliability was confirmed in the studies that reported the properties of the EQ-5D-5 L, and responsiveness reported in a study that was good. There were ceiling effects in seven studies. The overall utility value was higher in Japan (0.86, 95% CI: 0.80–0.92, p = 0.0001) thanCanada (0.79, 95% CI: 0.78–0.80, p = 0.81), and the United Kingdom (0.72, 95% CI: 0.64–0.79, p = 0.0001). Findings demonstrated validity, reliability of the EQ-5D-5 L in T2DM and the existence of ceiling effects. However, the assessment of responsiveness and sensitivity needs further observations.
Mapping spatial variation of population aging in China's mega cities
Creators: name: Xie, Bo
name: Zhou, Jie
name: Luo, Xiao
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Based on the statistics of the fifth and sixth censuses in China, this paper, which focuses on the spatial distribution characteristics of aging population in China's mega cities, examines the distribution of aging in Beijing, Shanghai, Guangzhou, and Wuhan. In this paper, an Aging Degree Index and an Aging Population Mean Center have been used to analyze the spatial distribution characteristics and spatial variation trends of aging population in mega cities. According to the research, the spatial distribution of aging population shows a faster development tendency of suburbanization from two different perspectives: one tendency is centrifugal spread associated with seniors who are moving from the city center to outer suburb areas, and the other is center concentration where the seniors who lived in the outer suburb areas are moving towards the city center.
Exploring different classification-dependent QSAR modelling strategies for HDAC3 inhibitors in search of meaningful structural contributors
Creators: name: Jha, T.
name: Jana, R.
name: Banerjee, S.
name: Baidya, S.K.
name: Amin, S.A.
name: Gayen, S.
name: Ghosh, B.
name: Adhikari, N.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Histone deacetylase 3 (HDAC3), a Zn2+-dependent class I HDACs, contributes to numerous disorders such as neurodegenerative disorders, diabetes, cardiovascular disease, kidney disease and several types of cancers. Therefore, the development of novel and selective HDAC3 inhibitors might be promising to combat such diseases. Here, different classification-based molecular modelling studies such as Bayesian classification, recursive partitioning (RP), SARpy and linear discriminant analysis (LDA) were conducted on a set of HDAC3 inhibitors to pinpoint essential structural requirements contributing to HDAC3 inhibition followed by molecular docking study and molecular dynamics (MD) simulation analyses. The current study revealed the importance of hydroxamate function for Zn2+ chelation as well as hydrogen bonding interaction with Tyr298 residue. The importance of hydroxamate function for higher HDAC3 inhibition was noticed in the case of Bayesian classification, recursive partitioning and SARpy models. Also, the importance of substituted thiazole ring was revealed, whereas the presence of linear alkyl groups with carboxylic acid function, any type of ester function, benzodiazepine moiety and methoxy group in the molecular structure can be detrimental to HDAC3 inhibition. Therefore, this study can aid in the design and discovery of effective novel HDAC3 inhibitors in the future.
"WHAT IS THE PLACE OF GRAMMAR IN ENGLISH LANGUAGE TEACHING?"
Creators: name: Kayumova, Baxtigul
Publisher: name: Zenodo
Year: 2024

description: This article discusses the process of teaching any foreign language, especially, English that requires all integrated skills. So each of them is equally in great demand for teaching English. Grammar is essential and beneficial for not only writers, journalists, and poets, but also for teacher of foreign languages, who are engaged in literary field. It includes annotation, keywords, introduction, main part, conclusion and references.
Responsibility, Language Movement, and Social Transformation: the Shifting Value of te reo for non-Māori in Aotearoa New Zealand
Creators: name: O'Toole, Michelle
Publisher: name: La Trobe
Year: 2022

description: Michelle O'Toole https://orcid.org/0000-0001-5141-3268 Responsibility,
Language Movement, and Social Transformation: the Shifting Value of te reo for
non-Māori in Aotearoa New Zealand Introduction 'I just feel that, as, as a citizen of
this ...
Cost and Health Impact Analysis of Herpes Zoster Vaccination in Norway
Creators: name: Flem, Elmira
name: Graham, Jonathan
name: Yi, Zinan
name: Wisløff, Torbjørn
name: Johnson, Kelly D.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: A decision analytic model was developed to estimate the cost-effectiveness of a national vaccination program against herpes zoster in Norway. The model analyzed six vaccination scenarios that included the live-attenuated zoster vaccine under different target ages of vaccination (60, 65, and 70 years) compared with no vaccination. A catch-up program implemented in the first year of the vaccination was included in three of the scenarios. The model followed the population of Norway over a 40-year time horizon to estimate costs and outcomes associated with vaccination. Immunization costs, costs related to herpes zoster (both healthcare sector and non-healthcare sector), the quality of life gains due to avoided cases of herpes zoster, and quality-of-life losses due to vaccine-related adverse events were estimated. A national vaccination program would result in reduction of the number of herpes zoster cases and decreased burden of illness. Vaccinating adults at 65 years of age with catch-up up to 70 years in the first year of the program was the most cost-effective strategy with the incremental cost per quality-adjusted life-year gained at NOK (Norwegian Krone) 245,459 from the societal perspective and NOK 248,637 from the health care system perspective.
Efectos del Control Constitucional en la Macroeconomía. Estudio de Caso : Sistema pensional Colombiano
Creators: name: Bocanument Arbeláez, Mauricio
Publisher: name: Universidad del Rosario
Year: 2005

description: Se critica a la Corte Constitucional porque su control constitucional sobre los derechossociales, ha afectado el presupuesto nacional, la asignación de recursos, la equidad y el interés general. La Corte se defiende aclarando que los derechos fundamentales pueden afectarse por el no reconocimiento de derechos sociales, en consecuencia se ha desarrollado una radicalización equívoca del problema, pues el problema no es si deben o no protegerse tales derechos, sino el medio para hacerlo. Sin embargo, la opinión de la Corte frente al sistema pensional, demuestra que no tiene una posición seria sobre el tema, hasta el punto de variar su jurisprudencia sobre la progresividad de los DHESC y de los derechos adquiridos.
Mapping spatial variation of population aging in China's mega cities
Creators: name: Xie, Bo
name: Zhou, Jie
name: Luo, Xiao
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Biotechnology

description: Based on the statistics of the fifth and sixth censuses in China, this paper, which focuses on the spatial distribution characteristics of aging population in China's mega cities, examines the distribution of aging in Beijing, Shanghai, Guangzhou, and Wuhan. In this paper, an Aging Degree Index and an Aging Population Mean Center have been used to analyze the spatial distribution characteristics and spatial variation trends of aging population in mega cities. According to the research, the spatial distribution of aging population shows a faster development tendency of suburbanization from two different perspectives: one tendency is centrifugal spread associated with seniors who are moving from the city center to outer suburb areas, and the other is center concentration where the seniors who lived in the outer suburb areas are moving towards the city center.
Calidad de vida a nivel regional : ¿debemos reconocer las diferencias?
Creators: name: Casas, Andres Fernando
name: Gamboa Niño, Luis Fernando
Publisher: name: Universidad del Rosario
Year: 2002

description: Los indicadores multivariados de Calidad de vida tienen la ventaja de ponderar cada una de las variables de acuerdo a la varianza de la población. En este documento se muestra la importancia de evaluar la calidad desde el punto de vista nacional y desde el punto de vista regional, por separado para evitar sesgos y juicios de valor erróneos en el momento de diseñar programas de política pública.
La importancia de la información en el mercado de trabajo
Creators: name: Riaga, Carlos
name: Casas, Andres Fernando
Publisher: name: Universidad del Rosario
Year: 2000

description: Este documento se enmarca dentro de la economía institucional y la teoría de loscontratos. Para dichas corrientes la incertidumbre constituye un elemento esencialdentro de los costos de transacción. Para minimizar la incidencia de dichos costos,los agentes prefieren enmarcar sus relaciones futuras en un contrato. La teoría económica ha especificado ciertos modelos que explican la forma en que individuos, con diferentes conjuntos de información y con diferentes actitudes ante el riesgo, pueden llegar a establecer mecanismos eficientes para hacer cumplir los contratos sin necesidad de acudir a terceros. Dichos modelos han sido utilizados para evidenciar el fenómeno de los salarios rígidos, como una propuesta inicial de cara a formalizar algunos desequilibrios que pueden presentarse en el mercado de trabajo, y que van más allá de la premisa de analizar el desempleo como el tipo de desequilibrio más frecuente. Este documento presenta una revisión de los fundamentos y características de dichos modelos.
Renewable Energy Today and Tomorrow
Creators: name: Polak, Yuri
Publisher: name: Zenodo
Year: 2024

description: The review paper discusses issues related to transition to renewable energy in order to reduce greenhouse gas emissions. Attention is paid to the conferences of specialists that have recently taken place under the auspices of the UN and in Moscow. Based on conversations with their participants, the problems that arise about this are described. As an illustration of the problems of the "green agenda" is the situation with the automotive industry, which currently produces up to 40% of environmental pollution.
Calificando el desempeño institucional : índices internacionales y su descripción de Colombia
Creators: name: Anzola Gil, Marcela
name: Villaveces-Niño, Marta-Juanita
Publisher: name: Universidad del Rosario
Year: 2022

description: El presente documento busca hacer un recuento del surgimiento y utilización de los índices internacionales como un mecanismo para evaluar la eficiencia institucional de los países. Durante la década de los noventa, organismos internacionales, centros académicos y organizaciones no gubernamentales coincidieron en el interés de elaborar índices de desempeño con el fin de caracterizar los países y establecer escalas internacionales comparativas de desempeño. En esta perspectiva, surgen algunos temas de interés como la gobernabilidad, la competitividad, la corrupción y el estado de las libertades civiles y políticas. En este sentido, el documento da una explicación de las razones académicas y coyunturales para el surgimiento de los índices y los temas de interés en calificar. Luego, hace una descripción de los índices de competitividad, gobernabilidad, corrupción y libertades económicas y políticas; se explica su metodología y establece las convergencias y divergencias entre índices del mismo tema. También presenta una revisión de la literatura nacional e internacional sobre los índices. Por último, se presenta el desempeño del país de acuerdo con las escalas internacionales. Al final concluimos que los índices internacionales han permitido una revisión comparada del desempeño institucional. Sin embargo, por problemas de acceso a la información y existencia de estadísticas, estos índices aún son prematuros para permitir una comparación real y objetiva entre los distintos países.
Development of best practices for scientific research vessel operations in a changing Arctic: A case study for R/V Sikuliaq.
Creators: name: Konar, B.
name: Frisch, L.
name: Moran, S.B.
Publisher: name: UNESCO/IOC
Year: 2017
Subjects: subject: Environmental impact
subject: Compliance
subject: Subsistence
subject: R/V Sikuliaq
subject: Indigenous communities
subject: Parameter Discipline::Environment::Human activity

description: Reduced sea ice has made the Arctic Ocean more accessible for vessel traffic. In turn, the heightened interest to better understand rapidly changing sea ice dynamics, ecosystems, and related ocean processes in the Arctic Ocean has led to closer interactions with and the need to avoid potential conflicts between scientific researchers and Indigenous coastal communities. In particular, researchers need to minimize spatial and temporal overlap of science activities with subsistence hunts as the Arctic is essential to Indigenous communities for their food security and cultural heritage. In this regard, a Community and Environmental Compliance Standard Operating Procedure (CECSOP) was recently developed for the R/V Sikuliaq, which is owned by the National Science Foundation and operated by the University of Alaska Fairbanks College of Fisheries and Ocean Sciences and is part of the University-National Oceanographic Laboratory System. The CECSOP was developed with input and guidance from Alaska Indigenous community groups, state and federal agencies, and sea-going scientists. Here the document's basic principles and procedures are described, as well as its utility in helping guide constructive discussions and interactions between scientific users of R/V Sikuliaq and subsistence hunting communities when research and subsistence hunt activities have spatial and temporal overlap. The CECSOP is a “living” document and subject to future modifications and improvements. It may serve as a model for other scientific, commercial and industrial vessel operators to ensure best practices between subsistence hunting communities and vessel operators in the Arctic.
Cost-effectiveness of daratumumab in combination with lenalidomide and dexamethasone for relapsed and/or refractory multiple myeloma
Creators: name: Wong, Xin Yi
name: Chng, Wee Joo
name: Aziz, Mohamed Ismail Abdul
name: Ng, Kwong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: This study evaluates the cost-effectiveness of daratumumab (D) in combination with lenalidomide and dexamethasone (Rd) for treatment of relapsed and/or refractory multiple myeloma in patients who have received at least one prior therapy in Singapore. A 3-state partitioned survival model was developed to evaluate the cost-effectiveness of lenalidomide and dexamethasone with or without daratumumab from a healthcare system perspective over 10 years. Clinical inputs were obtained from the POLLUX trial. Health state utilities were derived from the literature and direct medical costs obtained from public healthcare institutions. Sensitivity and scenario analyses were conducted to explore uncertainties. DRd was associated with a high base-case incremental cost-effectiveness ratio (ICER) of US$576,247 per quality-adjusted life year (QALY) gained, compared with Rd. According to one-way sensitivity analysis, ICER was most heavily influenced by time horizon, discount rate for outcomes, progression-free utility and cost of daratumumab. Regardless of the variation, DRd remained not cost-effective. Even when the cost of both daratumumab and lenalidomide dropped by 20% and 80%, the ICERs remained high at US$470,400 and US$152,860 per QALY gained. At current prices, the addition of daratumumab to lenalidomide and dexamethasone does not represent cost-effective use of healthcare resources in Singapore.
Potential antioxidant, α-glucosidase, butyrylcholinesterase and acetylcholinesterase inhibitory activities of major constituents isolated from Alpinia officinarum hance rhizomes: computational studies and in vitro validation
Creators: name: Al Garni, H.A.
name: El-Halawany, A.M.
name: Koshak, A.E.
name: Malebari, A.M.
name: Alzain, A.A.
name: Mohamed, G.A.
name: Ibrahim, S.R.M.
name: El-Sayed, N.S.
name: Abdallah, H.M.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Science Policy

description: Alpinia officinarum is a commonly used spice with proven folk uses in various traditional medicines. In the current study, six compounds were isolated from its rhizomes, compounds 1–3 were identified as diarylheptanoids, while 4–6 were identified as flavonoids and phenolic acids. The isolated compounds were subjected to virtual screening against α-glucosidase, butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) enzymes to evaluate their potential antidiabetic and anti-Alzheimer’s activities. Molecular docking and dynamics studies revealed that 3 exhibited a strong binding affinity to human a α- glucosidase crystal structure compared to acarbose. Furthermore, 2 and 5 demonstrated high potency against AChE. The virtual screening results were further supported by in vitro assays, which assessed the compounds’ effects on α-glucosidase, cholinesterases, and their antioxidant activities. 5-Hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenylheptan-3-one (2) showed potent antioxidant effect in both ABTs and ORAC assays, while p-hydroxy cinnamic acid (6) was the most potent in the ORAC assay. In contrary, kaempferide (4) and galangin (5) showed the most potent effect in metal chelation assay. 5-Hydroxy-1,7-diphenylhepta-4,6-dien-3-one (3) and 6 revealed the most potent effect as α-glucosidase inhibitors where compound 3 showed more potent effect compared to acarbose. Galangin (5) revealed a higher selectivity to BChE, while 2 showed the most potent activity to (AChE).
Physical activity and quality of life in severely obese adults during a two-year lifestyle intervention programme
Creators: name: Jepsen, Randi
name: Aadland, Eivind
name: Robertson, Lesley
name: Kolotkin, Ronette L.
name: Andersen, John Roger
name: Natvig, Gerd Karin
Publisher: name: figshare
Year: 2015
Subjects: Diseases
Health Care

description: It is unknown how changes in physical activity may affect changes in quality of life (QoL) outcomes during lifestyle interventions for severely obese adults. The purpose of this study was to examine associations in the patterns of change between objectively assessed physical activity as the independent variable and physical, mental, and obesity-specific QoL and life satisfaction as the dependent variables during a two-year lifestyle intervention. Forty-nine severely obese adults (37 women; years; body mass index kg/m2) participated in the study. Assessments were conducted four times using Medical Outcomes Study Short-Form 36 Health Survey (SF-36), Obesity-Related Problems (OP) scale, a single item on life satisfaction, and accelerometers. The physical component summary (PCS) score and the mental component summary (MCS) score were used as SF-36 outcomes. Associations were determined using linear regression analyses and reported as standardized coefficients (stand. coeff.). Change in physical activity was independently associated with change in PCS (stand. coeff. = 0.35, ), MCS (stand. coeff. = 0.51, ), OP (stand. coeff. = −0.31, ), and life satisfaction (stand. coeff. = 0.39, ) after adjustment for gender, age, and change in body mass index.
Additional file 1 of Effectiveness of a multi-level intervention to reduce men’s perpetration of intimate partner violence: a cluster randomised controlled trial
Creators: name: Christofides, Nicola J.
name: Hatcher, Abigail M.
name: Dumisani Rebombo
name: Ruari-Santiago McBride
name: Shehnaz Munshi
name: Pino, Angelica
name: Abdelatif, Nada
name: Peacock, Dean
name: Levin, Jonathan
name: Jewkes, Rachel K.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1.Supplementary Table 1. Meansures of fit for models one through three latent classes.
Evaluating model misspecification in independent component analysis
Creators: name: Seonjoo Lee
name: Caffo, Brian S.
name: Balaji Lakshmanan
name: Dzung L. Pham
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Earth and Environmental Sciences

description: Independent component analysis (ICA) is a popular blind source separation technique used in many scientific disciplines. Current ICA approaches have focused on developing efficient algorithms under specific ICA models, such as instantaneous or convolutive mixing conditions, intrinsically assuming temporal independence or autocorrelation of the sources. In practice, the true model is not known and different ICA algorithms can produce very different results. Although it is critical to choose an ICA model, there has not been enough research done on evaluating mixing models and assumptions, and how the associated algorithms may perform under different scenarios. In this paper, we investigate the performance of multiple ICA algorithms under various mixing conditions. We also propose a convolutive ICA algorithm for echoic mixing cases. Our simulation studies show that the performance of ICA algorithms is highly dependent on mixing conditions and temporal independence of the sources. Most instantaneous ICA algorithms fail to separate autocorrelated sources, while convolutive ICA algorithms depend highly on the model specification and approximation accuracy of unmixing filters.
Forms of participatory democracy : an analytical framework based on the experiences of Bolivia, brazil and Colombia
Creators: name: Forero Pineda, Clemente
name: Sepulveda, Carlos E.
Publisher: name: Universidad del Rosario
Year: 2004

description: Based on the experiences of Colombia, Brazil and Bolivia, the paper proposes a general analytical framework for participatory mechanisms. The analysis is oriented to detect the incentives in each system and theethics and behavior sustaining them. It investigates about the sustainability of participatory democracy, in the face of tensions with representative democracy. The article presents a theoretical framework built from theseexperiences of institutional design and political practice, and confronts it against the theoretical conceptualizationsof participatory democracy in Bobbio, Sartori, Elster and Nino, among others. In this context, different waysin which those schemes can be inserted in the political systems become apparent, along with the variables thatresult from combining elements of direct, representative and participatory democracy”
Anti-inflammatory action of new hybrid N-acyl-[1,2]dithiolo-[3,4-c]quinoline-1-thione
Creators: name: Medvedeva, S.M.
name: Petrou, A.
name: Fesatidou, M.
name: Gavalas, A.
name: Geronikaki, A.A.
name: Savosina, P.I.
name: Druzhilovskiy, D.S.
name: Poroikov, V.V.
name: Shikhaliev, K.S.
name: Kartsev, V.G.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Most of pharmaceutical agents display a number of biological activities. It is obvious that testing even one compound for thousands of biological activities is not practically possible. A computer-aided prediction is therefore the method of choice in this case to select the most promising bioassays for particular compounds. Using the PASS Online software, we determined the probable anti-inflammatory action of the 12 new hybrid dithioloquinolinethiones derivatives. Chemical similarity search in the World-Wide Approved Drugs (WWAD) and DrugBank databases did not reveal close structural analogues with the anti-inflammatory action. Experimental testing of anti-inflammatory activity of the synthesized compounds in the carrageenan-induced inflammation mouse model confirmed the computational predictions. The anti-inflammatory activity of the studied compounds (2a, 3a-3k except for 3j) varied between 52.97% and 68.74%, being higher than the reference drug indomethacin (47%). The most active compounds appeared to be 3h (68.74%), 3k (66.91%) and 3b (63.74%) followed by 3e (61.50%). Thus, based on the in silico predictions a novel class of anti-inflammatory agents was discovered.
Aversión al riesgo y eficiencia de escala en los bancos : Incluyendo variables de riesgo y regulación
Creators: name: Ramírez Gómez, Manuel
name: Olaya Pardo, Ana María
Publisher: name: Universidad del Rosario
Year: 2022

description: Este artículo aplica las teorías del enfoque moderno en la medición de la actividad bancaria. Con el fin de determinar la eficiencia de escala y el nivel de aversión al riesgo en los directivos de los bancos en Colombia, utiliza una función de costos translogarítmica multiproducto, que incorpora variables de riesgo y de regulaciónque caracterizaron y afectaron la actividad bancaria durante el período de crisis financiera. Encuentra que los directivos son adversos al riesgo y por lo tanto, la utilidad está en función de otras variables adicionales al beneficio. Demuestra que las medidas de regulación además de incrementar los costos generan un mayor nivelde aversión al riesgo de los directivos de los bancos, aumentando la demanda de capital financiero hasta niveles que no les permiten minimizar costos. Por último, encuentra que no existen economías de escala al incluir en su medición variables de riesgo y de regulación durante el período de desarrollo de la crisis financiera
Anotaciones sobre cultura en Colombia
Creators: name: Anzola Gil, Marcela
name: Villaveces-Niño, Marta-Juanita
Publisher: name: Universidad del Rosario
Year: 2005

description: El presente documento hace una revisión de conceptos como raza, etnia, clases sociales, vida familiar y tendencias poblacionales en Colombia y busca hacer un recuento de la forma en la que han sido utilizados para explicar algunas realidades colombianas y cómo pueden seguir vigentes en el análisis del país. Adicionalmente, se hace una revisión de la legislación para cada concepto, mostrando los cambios más significativos en loreferente a raza y etnias, familia y población.
Evolution of the Gelasian (Pleistocene) slope turbidite systems of southern Marche (Peri-Adriatic basin, central Italy)
Creators: name: Celma, Claudio Di
name: Teloni, Riccardo
name: Rustichelli, Andrea
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Examples of slope channels and canyons being diverted by structurally related sea-floor topography are commonly found both on the modern seabed and in the subsurface, in deep-water fold and thrust belts but their depositional histories have rarely been documented using examples from outcrop. The synthesis of outcrop (original geological field mapping at 1:10,000 scale) and subsurface data sets from the early Pleistocene stratigraphic succession of the Peri-Adriatic basin provides a window into the overall evolutionary pattern of large intraslope turbidite systems that, during the Gelasian (2.58–1.80 Ma), shed Apennine-derived clastic sediments into the adjacent deep-water basin. Trends from mapping and paleocurrent indicators converge to indicate that the sea-floor bathymetric expression of a thrust-related anticline, the north-trending Jesi-Nereto-Zaccheo structure, likely influenced the downslope transport direction of gravity flows and sediment dispersal pattern. During early and middle Gelasian time, coarse-grained turbidite deposition occurred on the western flank of the intraslope anticline by westerly sourced, northward-flowing turbidity currents, indicating that the opposing sea-floor topography was sufficient to cause the diversion of turbidite systems, forcing them to travel near parallel to the east-facing regional paleoslope for significant distances. By very late Gelasian time, the intraslope accommodation space on the western flank of the anticline had filled and turbidites were dispersed through dip-oriented conduits incising across the crest of the underlying structure.
¿Podemos sostener la deuda pública?
Creators: name: Arango, Luis Eduardo
name: Posada, Carlos Esteban
Publisher: name: Universidad del Rosario
Year: 2022

description: Se presentan argumentos que indican que es necesario, ahora, diseñar una estrategia convincente de generación de superávit fiscales primarios futuros (permanentes) cuyo rango está entre 0.9% y 1.5% del PIB, de manera que el actual nivel de endeudamiento pueda ser juzgado sostenible. En tal caso, su resultado inmediato sería la reducción del “spread” de la deuda.
Jovenes y el sistema pensional colombiano : inequidad intergeneracional
Creators: name: Guerra Forero, José Alberto
name: Pombo de Buenaventura, Cristina
name: Acosta Navarro, Olga Lucía
Publisher: name: Universidad del Rosario
Year: 2005

description: El Sistema Pensional Colombiano se encuentra en una de las etapas más críticas de los últimos años, representando el mayor problema fiscal que enfrentarán las finanzas públicas hoy y en los próximos veinte años. Las modificaciones a la legislación hechas desde 1993 beneficiaron a contados sectores de la sociedad y desencadenaron en onerosos beneficios para unos pocos. Más que hacia un enfoque fiscal, este trabajo busca traducir el problema pensional como un problema de inequidad intergeneracional en el cual, las generaciones actuales y venideras tendrán, además de ahorrar para generar su pensión, cotizar para lograr mantener los beneficios del esquema pensional tal como se contemplan actualmente. Se encuentra que la tendencia de afiliación a los regímenes tiende a ser bastante diferente entre grupos etáreos, mientras que los mayores se concentran en el Régimen de Prima Media, los jóvenes lo hacen en el Régimen de Ahorro Individual. Las condiciones del mercado laboral se presentan como uno de los determinantes del perfil sostenible del sistema pensional pero una mayor tasa de informalidad y un mayor desempleo lo han caracterizado en los últimos cinco años. Se encuentra además que las principales variables que definen el sistema pensional permanecieron constantes a pesar de cambios estructurales de gran envergadura.
Economic integration. An overview of basic economic theory and other related issues
Creators: name: Arguello, Ricardo
Publisher: name: Universidad del Rosario
Year: 2022

description: Este documento presenta una visión amplia de la Teoría de Integración Económica desde el punto de vista de la teoría de unión aduanera. Se argumenta que dicha teoría carece de integración y que los recientes desarrollos en el tema no parecen resolver esta falla. A pesar de esto, se sugiere que los desarrollos teóricos surgidos a partir del trabajo seminal de Viner y posteriormente desarrollados por otros teóricos, son aún útiles como herramienta de investigación empírica en el tema.
Estimación de la discriminación salarial por género para los trabajadores asalariados urbanos de Colombia (1984-1999)
Creators: name: Baquero-Melo, Jairo
Publisher: name: Universidad del Rosario
Year: 2001

description: En este documento se realiza una nueva estimación de la discriminación salarial porgénero utilizando la metodología de descomposición de ecuaciones mincerianas sugerida por Oaxaca (1973) utilizando datos de la Encuesta Nacional de Hogares 1984 – 1999. Se detecta un patrón estable que mantiene un diferencial salarial no explicado por variables de productividad, a favor de los hombres. Al parecer el incremento o reducción de esta brecha puede estar relacionado con el ciclo económico.
Desarrollo, bienestar y comparaciones interpersonales
Creators: name: Gamboa Niño, Luis Fernando
name: Casas, Andres Fernando
name: Cortes, Darwin
Publisher: name: Universidad del Rosario
Year: 2022

description: El presente documento intenta esquematizar los conceptos que han sido estudiados en la teoría económica y que son necesarios para evaluar las condiciones de vida de las personas. Se estudian las distintas posturas que se enmarcan tanto dentro de la vieja como de la nueva economía del bienestar y se concluye que la teoría económica ha llegado a un concepto de bienestar y justicia ampliamente definido que permite evaluar de una manera distinta a los agentes y que también, permite considerar posturas alternativas cuando se habla de condiciones de vida.