cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Identification of Novel Human WW Domain-containing Proteins by Cloning of Ligand Targets
Creators: name: Fowlkes, Dana M.
name: Sparks, Andrew B.
name: McConnell, Stephen J.
name: Kay, Brian K.
name: Pirozzi, Gregorio
name: Carter, J. Mark
name: Uveges, Albert J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: A recently described protein module consisting of 35-40 semiconserved residues, termed the WW domain, has been identified in a number of diverse proteins including dystrophin and Yes-associated protein (YAP). Two putative ligands of YAP, termed WBP-1 and WBP-2, have been found previously to contain several short peptide regions consisting of PPPPY residues (PY motif) that mediate binding to the WW domain of YAP. Although the function(s) of the WW domain remain to be elucidated, these observations strongly support a role for the WW domain in protein-protein interactions. Here we report the isolation of three novel human cDNAs encoding a total of nine WW domains, using a newly developed approach termed COLT (cloning of ligand targets), in which the rapid cloning of modular protein domains is accomplished by screening cDNA expression libraries with specific peptide ligands. Two of the new genes identified appear to be members of a family of proteins, including Rsp5 and Nedd-4, which have ubiquitin-protein ligase activity. In addition, we demonstrate that peptides corresponding to PY and PY-like motifs present in several known signaling or regulatory proteins, including RasGAP, AP-2, p53BP-2 (p53-binding protein-2), interleukin-6 receptor-alpha, chloride channel CLCN5, and epithelial sodium channel ENaC, can selectively bind to certain of these novel WW domains.
Loss of Binding and Entry of Liposome-DNA Complexes Decreases Transfection Efficiency in Differentiated Airway Epithelial Cells
Creators: name: Johnson, Larry G.
name: Randell, Scott H.
name: Boucher, Richard C.
name: Matsui, Hirotoshi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: The target cells for gene therapy of cystic fibrosis lung disease are the well differentiated cells that line airway lumens. Employing cultures of airway epithelial cells that grow like "islands" and exhibit a continuum of cellular differentiation, we studied the mechanisms that render well differentiated cells more difficult to transfect with cationic liposomes than poorly differentiated cells. The poorly differentiated cells at the edge of the islands were transfectable with liposome-DNA complexes (pCMVbeta:LipofectACE = 1:5 (w/w)), whereas the more differentiated cells in the center of the islands were not. Evaluation of the steps leading to lipid-mediated transfection revealed that edge cells bound more liposome-DNA complexes, in part due to a more negative surface charge (as measured by cationized ferritin binding), and that edge cells internalized more liposome-DNA complexes than central cells. Edge cells exhibited receptor-mediated endocytosis of LDL, pinocytosis of 10-nm microspheres, and phagocytosis of 2-microm microspheres, whereas central cells were only capable of receptor-mediated endocytosis. Cytochalasin B, which inhibited pinocytosis by 65% and phagocytosis by 93%, decreased edge cell liposome-DNA complex entry by 50%. Potassium depletion, which decreased phagocytosis by >90% but had no effect on pinocytosis, inhibited edge cell liposome-DNA complex entry by 71%. These results indicate that liposome-DNA complexes enter edge cells via phagocytosis and that this pathway is not detectable in central cells. In conclusion, both reduced negative surface charge and absence of phagocytosis internalization pathways in relatively differentiated cells may explain differentiation-dependent decrements in cationic liposome-mediated gene transfer in airway epithelia.
Dark Freeze-out Cogenesis
Creators: name: Chu, Xiaoyong
name: Cui, Yanou
name: Pradler, Josef
name: Shamma, Michael
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We propose a new mechanism where a multi-component dark sector generates the observed dark matter abundance and baryon asymmetry and thus addresses the coincidence between the two. The thermal freeze-out of dark matter annihilating into meta-stable dark partners sets the dark matter relic abundance while providing the out-of-equilibrium condition for baryogenesis. The meta-stable state triggers baryon asymmetry production by its decay well after the freeze-out and potentially induces a period of early matter domination before its decay. The dark matter and baryon abundances are related through number conservation within the dark sector (cogenesis). The "coincidence" is a natural outcome with GeV- to TeV-scale symmetric dark matter and the dark sector's interactions with the Standard Model quarks. We present a UV-complete model and explore its phenomenological predictions, including dark matter direct detection signals, LHC signatures of new massive particles with color charges and long-lived particles with displaced vertices, dark matter-induced nucleon conversions, (exotic) dark matter indirect detection signals, and effects on the cosmological matter power spectrum. As a side result, we provide a novel analytical treatment for dark sector freeze-out, which may prove useful in the study of related scenarios.
description: 31 pages, 13 figures, 1 appendix. References and minor comments added, conclusions unchanged, matches published version
An ageist perspective on age and older adults in information behaviour research
Creators: name: Hillebrand, Vera
Publisher: name: Humboldt-Universität zu Berlin
Year: 2022
Subjects: subject: information seeking behaviour
subject: older adults
subject: aging
subject: ageism
subject: 020 Bibliotheks- und Informationswissenschaften

description: This study aims to answer the question what kind of research exists on aging and older adults in information behaviour and information seeking. A systematic literature review was conducted in two databases, LISA and Scopus. The results were refined and tagged thematically and clustered into main research topics. (Online) health information behaviour is the largest research topic in relation to aging and older adults. Underrepresented topics are information needs and behaviour outside of the health care sector. An ageist perspective is strongly present in information behaviour studies. Existing research on (online) health information behaviour primarily addresses a negative aspect of old age, frailty and illness, which may amplify the stereotypical image of older people and aging. This paper suggests that the research field should turn to topics that are more diverse and use the demographic variable of age more carefully in order to mitigate ageism.
La Biblioteca Warburg e il suo fine (1923)
Creators: name: Fritz Saxl, Michela Maguolo
Publisher: name: La Rivista di Engramma
Year: 2023
Subjects: Fritz Saxl
Aby Warburg
Warburg Library
Venus and Eve
Court Love

description: Die Bibliothek Warburg und ihr Ziel is a conference held by Fritz Saxl at the Warburg Institute of Cultural Sciences during the academic year 1921-1922, and published in 1923 in “Vorträge der Bibliothek Warburg 1921 – 1922”, edited by Saxl himself (Bd. 1, Leipzig/Berlin 1923, 1–10). In presenting the Library, Saxl exemplifies the particular approach to the history of the survival of Antiquity, on which the Library and the Institute of Cultural Sciences are based, through the figures of Venus and Eve and their representation in different ages. In presenting the Library, Saxl exemplifies the particular approach to the history of the survival of Antiquity, on which the Library and the Institute of Cultural Sciences is based, through the figures of Venus and Eve and their representation in different ages. The text has been translated into Italian by Michela Maguolo.
O Novo Hospital Pediátrico de Coimbra
Creators: name: Dias, Jorge Amil
Publisher: name: Portuguese Journal of Pediatrics
Year: 2014

description: A comunicação social anunciou recentemente a presença do Primeiro-Ministro para a assinatura do contrato de construção do novo Hospital Pediátrico de Coimbra (HPC). Não é a primeira vez que um membro do Governo se desloca a Coimbra a pretexto do novo hospital, e a ocasião pré-eleitoral contribuiria ainda mais para desvalorizar essa visita, não fora o facto de se registar agora uma importante evolução do processo. Enquanto noutras ocasiões assistimos a promessas e até palavras emocionadas, desta vez tratou-se de passar das intenções para o contrato de execução. Ninguém pode estar absolutamente seguro que tenham terminado as preocupações da comunidade de saúde pediátrica e da população, pois há sempre oportunidades para emperrar o processo, mas agora existe um contrato de construção que define regras e prazos, Há pois um grande avanço que justifica palavras de apreço e felicitações a todos os obreiros deste longo e penoso caminho; essa saudação inclui naturalmente os profissionais de saúde e dirigentes do Hospital Pediátrico, mas também a população que acreditou e várias vezes se manifestou publicamente em defesa do seu hospital pediátrico.
description: Portuguese Journal of Pediatrics, vol. 36 n.º 1 (2005)
Proton-${}^3$H scattering calculation: Elastic and charge-exchange reactions up to 30 MeV
Creators: name: Deltuva, A.
name: Fonseca, A. C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Proton-${}^3$H elastic scattering and charge-exchange reaction ${}^3$H$(p,n){}^3$He in the energy regime above four-nucleon breakup threshold are described in the momentum-space transition operator framework. Fully converged results are obtained using realistic two-nucleon potentials and two-proton Coulomb force as dynamic input. Differential cross section, proton analyzing power, outgoing neutron polarization, and proton-to-neutron polarization transfer coefficients are calculated between 6 and 30 MeV proton beam energy. Good agreement with the experimental data is found for the differential cross section both in elastic and charge-exchange reactions; the latter shows a complicated energy and angular dependence. The most sizable discrepancies between predictions and data are found for the proton analyzing power and outgoing neutron polarization in the charge-exchange reaction, while the respective proton-to-neutron polarization transfer coefficients are well described by the calculations.
description: 6 figures, to be published in Phys. Rev. C
Model for XPC-independent Transcription-coupled Repair of Pyrimidine Dimers in Humans
Creators: name: Sancar, Aziz
name: Mu, David
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: In humans, DNA lesions such as pyrimidine dimers in the template strand of genes transcribed by RNA polymerase II are repaired faster than those in the coding strand and nontranscribed regions of the genome. This phenomenon, referred to as transcription-coupled repair (i) requires active transcription, (ii) does not require the XPC gene product which is essential for general/basal repair reactions, and (iii) requires the CSA and CSB proteins. We have developed an in vitro model system that consists of purified human excision repair factors and a DNA substrate analogous to a transcription bubble terminating at a cyclobutane thymine dimer. In this system the thymine dimer was excised independent of XPC. Furthermore, the thymine dimer in the bubble-containing substrate was removed approximately 3-fold faster by the excision repair nuclease reconstituted with or without XPC, compared with the removal of thymine dimer from a base paired duplex by the entire set of excision nuclease factors. These results provide important insight into the mechanism of transcription-coupled repair in humans.
title: Procedural justice theory and the black box of causality.
Creators: name: Pósch, Krisztián
Publisher: name: London School of Economics and Political Science (LSE)
Year: 2018
Subjects: subject: HM Sociology

description: This thesis makes a theoretical and a methodological contribution. Theoretically, it tests certain predictions of procedural justice policing, which posits that neutral, fair, and respectful treatment by the police is the cornerstone of fruitful police-public relations, in that procedural justice leads to increased police legitimacy, and that legitimacy engenders societally desirable outcomes, such as citizens’ willingness to cooperate with the police and compliance with the law. Methodologically, it identifies and assesses causal mechanisms using a family of methods developed mostly in the field of epidemiology: causal mediation analysis. The theoretical and methodological aspects of this thesis converge in the investigation of (1) the extent to which procedural justice mediates the impact of contact with the police on police legitimacy and psychological processes (Paper 1), (2) the mediating role of police legitimacy on willingness to cooperate with the police and compliance with the law (Paper 3, Paper 4), and (3) the psychological drivers that channel the impact of procedural justice on police and legal legitimacy (Paper 2). This thesis makes use of a randomised controlled trial (Scottish Community Engagement Trial), four randomised experiments, and one experiment with parallel (encouragement) design on crowdsourced samples from the US and the UK (recruited through Amazon Turk and Prolific Academic). The causal evidence attests to the centrality of procedural justice, which mediates the impact of an encounter with the police on police legitimacy, and influences psychological processes and police legitimacy. Personal sense of power, not social identity, is the causal mediator of the effect of procedural justice on police and legal legitimacy. Finally, different aspects of legitimacy transmit the influence of procedural justice on distinct outcomes, with duty to obey affecting legal compliance and normative alignment affecting willingness to cooperate. In sum, most of the causal evidence is congruent with the theory of procedural justice.
(1972) Herbert Edward Boddy
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary Figure 1 from The contributions of ankle, knee and hip joint work to individual leg work change during uphill and downhill walking over a range of speeds.
Creators: name: Montgomery, Jana R.
name: Grabowski, Alena M.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Ensemble averages of 10 strides for 20 subjects' ankle joint A) angles, B) moments, and C) powers versus % of a stride starting at heel-strike for each walking speed on each slope. Ankle angles are presented for the entire stride and ankle joint moments and powers are presented for the stance phase only (0–70% of a stride). Each column represents a different slope from −9° (left-most column) to +9° (right-most column).
The Coronal Global Evolutionary Model: Using HMI Vector Magnetogram and Doppler Data to Model the Buildup of Free Magnetic Energy in the Solar Corona
Creators: name: Fisher, George H.
name: Abbett, William. P.
name: Bercik, David J.
name: Kazachenko, Maria D.
name: Lynch, Benjamin J.
name: Welsch, Brian T.
name: Hoeksema, J. Todd
name: Hayashi, Keiji
name: Liu, Yang
name: Norton, Aimee A.
name: Dalda, Alberto Sainz
name: Sun, Xudong
name: DeRosa, Marc L.
name: Cheung, Mark C. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The most violent space weather events (eruptive solar flares and coronal mass ejections) are driven by the release of free magnetic energy stored in the solar corona. Energy can build up on timescales of hours to days, and then may be suddenly released in the form of a magnetic eruption, which then propagates through interplanetary space, possibly impacting the Earth's space environment. Can we use the observed evolution of the magnetic and velocity fields in the solar photosphere to model the evolution of the overlying solar coronal field, including the storage and release of magnetic energy in such eruptions? The objective of CGEM, the Coronal Global Evolutionary Model, funded by the NASA/NSF Space Weather Modeling program, is to develop and evaluate such a model for the evolution of the coronal magnetic field. The evolving coronal magnetic field can then be used as a starting point for magnetohydrodynamic (MHD) models of the corona, which can then be used to drive models of heliospheric evolution and predictions of magnetic field and plasma density conditions at 1AU.
description: 7 pages, 2 figures. Feature article in Space Weather 13
Supplementary Figure 3 from The contributions of ankle, knee and hip joint work to individual leg work change during uphill and downhill walking over a range of speeds
Creators: name: Montgomery, Jana R.
name: Grabowski, Alena M.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Ensemble averages of 10 strides for 20 subjects' hip joint A) angles, B) moments, and C) powers versus % of a stride starting at heel-strike for each walking speed on each slope. Hip angles are presented for the entire stride and hip joint moments and powers are presented for the stance phase only (0–70% of a stride). Each column represents a different slope from −9° (left-most column) to +9° (right-most column).
(1973) William Mathers
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary Figure 2 from The contributions of ankle, knee and hip joint work to individual leg work change during uphill and downhill walking over a range of speeds
Creators: name: Montgomery, Jana R.
name: Grabowski, Alena M.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Ensemble averages of 10 strides for 20 subjects' knee joint A) angles, B) moments, and C) powers versus % of a stride starting at heel-strike for each walking speed on each slope. Knee angles are presented for the entire stride and knee joint moments and powers are presented for the stance phase only (0–70% of a stride). Each column represents a different slope from −9° (left-most column) to +9° (right-most column).
Planar immersion lens with metasurfaces
Creators: name: Ho, John S.
name: Qiu, Brynan
name: Tanabe, Yuji
name: Yeh, Alexander J.
name: Fan, Shanhui
name: Poon, Ada S. Y.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The solid immersion lens is a powerful optical tool that allows light entering material from air or vacuum to focus to a spot much smaller than the free-space wavelength. Conventionally, however, they rely on semispherical topographies and are non-planar and bulky, which limits their integration in many applications. Recently, there has been considerable interest in using planar structures, referred to as metasurfaces, to construct flat optical components for manipulating light in unusual ways. Here, we propose and demonstrate the concept of a planar immersion lens based on metasurfaces. The resulting planar device, when placed near an interface between air and dielectric material, can focus electromagnetic radiation incident from air to a spot in material smaller than the free-space wavelength. As an experimental demonstration, we fabricate an ultrathin and flexible microwave lens and further show that it achieves wireless energy transfer in material mimicking biological tissue.
Mutation of a Highly Conserved Arginine in Motif IV of Escherichia coli DNA Helicase II Results in an ATP-binding Defect
Creators: name: Matson, Steven W.
name: Hall, Mark C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: A site-directed mutation in motif IV of Escherichia coli DNA helicase II (UvrD) was generated to examine the functional significance of this region. The highly conserved arginine at position 284 was replaced with alanine to construct UvrD-R284A. The ability of the mutant allele to function in methyl-directed mismatch repair and UvrABC-mediated nucleotide excision repair was examined by genetic complementation assays. The R284A substitution abolished function in both DNA repair pathways. To identify the biochemical defects responsible for the loss of biological function, UvrD-R284A was purified to apparent homogeneity, and its biochemical properties were compared with wild-type UvrD. UvrD-R284A failed to unwind a 92-base pair duplex region and was severely compromised in unwinding a 20-base pair duplex region. The Km of UvrD-R284A for ATP was significantly greater than 3 mM compared with 80 microM for UvrD. A large decrease in ATP binding was confirmed using a nitrocellulose filter binding assay. These data suggested that the R284A mutation severely reduced the affinity of helicase II for ATP. The reduced unwinding activity and loss of biological function of UvrD-R284A was probably the result of decreased affinity for ATP. These results implicate motif IV of superfamily I helicases in nucleotide binding and represent the first characterization of a helicase mutation outside motifs I and II that severely impacted the Km for ATP.
Current orderings of interacting electrons in bilayer graphene
Creators: name: Yan, Xin-Zhong
name: Ting, C. S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: By taking into account the possibility of all the intralayer as well as the interlayer current orderings, we derive an eight-band model for interacting electrons in bilayer graphene. With the numerical solution to the model, we show that only the current orderings between the same sublattice sites can exist within the range of the physical interacting strength. This result confirms our previous model of spin-polarized-current phase for the ground-state of interacting electrons in bilayer graphene that resolves a number of experimental puzzles.
description: 10+ pages, 8 figures
Heldur Nestori välipäevik nr 3
Creators: name: Nestor, Heldur
Publisher: name: Tallinna Tehnikaülikooli Geoloogia Instituut
Year: 1965
Subjects: Silurian
Estonia
Latvia
drill cores
geological descriptions

description: Field notebook with description Silurian in drill cores Estonia and Latvia (years 1965, 1969)
Native Recombinant Cyclophilins A, B, and C Degrade DNA Independently of Peptidylprolyl cis-trans -Isomerase Activity: POTENTIAL ROLES OF CYCLOPHILINS IN APOPTOSIS
Creators: name: Hughes Jr., Francis M.
name: Montague, Jennifer W.
name: Cidlowski, John A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Previous work in our laboratory (Montague, J., Gaido, M., Frye, C., and Cidlowski, J. (1994) J. Biol. Chem. 269, 18877-18880) has shown that human recombinant cyclophilins A, B, and C have sequence homology with the apoptotic nuclease NUC18 and that denatured cyclophilins can degrade DNA. We have now evaluated the nucleolytic activity of recombinant cyclophilins under native conditions. We show that nuclease activity inherent to cyclophilins is distinct from cis-trans-peptidylprolyl isomerase activity and is similar to that described for apoptotic nucleases. Cyclophilin nucleolytic activity is stimulated by Ca2+ and/or Mg2+, with a combination of the two being optimal for cyclophilins A and B. Mg2+ alone is sufficient for cyclophilin C nuclease activity. pH optimums are in the range of pH 7.5-9.5. Cyclophilins can degrade both single-stranded and double-stranded DNA. Additionally, cyclophilins produce 3'-OH termini in linear double-stranded substrates, suggesting the cuts produced are similar to those of apoptotic cells. Cyclophilins also display endonucleolytic activity, demonstrated by their ability to degrade supercoiled DNA. In the absence of ions, cyclophilins bind linearized DNA. When added to nuclei from nonapoptotic cells, cyclophilin C induces 50-kilobase pair DNA fragmentation but not internucleosomal fragmentation. Together, these data suggest that cyclophilins are involved in degradation of the genome during apoptosis.
Supplementary Figure 1 from The contributions of ankle, knee and hip joint work to individual leg work change during uphill and downhill walking over a range of speeds
Creators: name: Montgomery, Jana R.
name: Grabowski, Alena M.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Ensemble averages of 10 strides for 20 subjects' ankle joint A) angles, B) moments, and C) powers versus % of a stride starting at heel-strike for each walking speed on each slope. Ankle angles are presented for the entire stride and ankle joint moments and powers are presented for the stance phase only (0–70% of a stride). Each column represents a different slope from −9° (left-most column) to +9° (right-most column).
Understanding interagency relationships in the sharing of government data: a meta-analysis
Creators: name: Zhou, Lihong
name: Hu, Jiangfeng
name: Xu, Jie
Publisher: name: Humboldt-Universität zu Berlin
Year: 2022
Subjects: subject: Data sharing
subject: Inter-organisation relations
subject: Government agencies
subject: Government data
subject: Public sector
subject: 020 Bibliotheks- und Informationswissenschaften

description: This paper reports on a research study that aimed to understand and qualify the influences of interagency relationships on interagency government data sharing (IDS). Using a meta-analysis approach, 76 interviews previously collected from three city governments in China were analysed under the theoretical lens of a unified social network theory of inter-organisational relations (IOR).Results. The meta-analysis shows that interagency data sharing is influenced by the constitution and determinants of interagency relationships. A conceptualisation of the findings indicated that tensions between government agencies are the core cause of the lack of interagency data sharing. Therefore, effective management of interagency tensions should become a central strategy for enhancing interagency data sharing. This paper provides a novel perspective on the conceptualisation of interagency data sharing problems and a new approach to strengthen interagency data sharing in practice.
(1971) John Henry Boddy
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
NCAM140 Interacts with the Focal Adhesion Kinase p125 fak and the SRC-related Tyrosine Kinase p59 fyn
Creators: name: Baragona, Steven C.
name: Beggs, Hilary E.
name: Maness, Patricia F.
name: Hemperly, John J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Axonal growth cones respond to adhesion molecules and extracellular matrix components by rapid morphological changes and growth rate modification. Neurite outgrowth mediated by the neural cell adhesion molecule (NCAM) requires the src family tyrosine kinase p59(fyn) in nerve growth cones, but the molecular basis for this interaction has not been defined. The NCAM140 isoform, which is found in migrating growth cones, selectively co-immunoprecipitated with p59(fyn) from nonionic detergent (Brij 96) extracts of early postnatal mouse cerebellum and transfected rat B35 neuroblastoma and COS-7 cells. p59(fyn) did not associate significantly with the NCAM180 isoform, which is found at sites of stable neural cell contacts, or with the glycophosphatidylinositol-linked NCAM120 isoform. pp60(c-)src, a tyrosine kinase that promotes neurite growth on the neuronal cell adhesion molecule L1, did not interact with any NCAM isoform. Whereas p59(fyn) was constitutively associated with NCAM140, the focal adhesion kinase p125(fak), a nonreceptor tyrosine kinase known to mediate integrin-dependent signaling, became recruited to the NCAM140-p59(fyn) complex when cells were reacted with antibodies against the extracellular region of NCAM. Treatment of cells with a soluble NCAM fusion protein or with NCAM antibodies caused a rapid and transient increase in tyrosine phosphorylation of p125(fak) and p59(fyn). These results suggest that NCAM140 binding interactions at the cell surface induce the assembly of a molecular complex of NCAM140, p125(fak), and p59(fyn) and activate the catalytic function of these tyrosine kinases, initiating a signaling cascade that may modulate growth cone migration.
Avoiding negative information as a strategy for emotion regulation
Creators: name: Heinstrom, Jannica
name: Nikou, Shahrokh
name: Sormunen, Eero
Publisher: name: Humboldt-Universität zu Berlin
Year: 2022
Subjects: subject: information avoidance
subject: personality
subject: negative emotionality
subject: sense of coherence
subject: blunting
subject: 020 Bibliotheks- und Informationswissenschaften

description: The aim of the paper is to investigate whether the personality trait negative emotionality and sense of coherence influence emotionally motivated information avoidance, i.e., avoidance of negative information that potentially evoke anxiety or worry. Data from 412 respondents was collected in a survey which measured negative emotionality, sense of coherence and information avoidance. A conceptual model is proposed, and structural equation modelling (SEM) was applied to analyse the data.Results. Negative emotionality was found to influence information avoidance not only directly, but also indirectly through the manageability dimension of sense of coherence. In other words, manageability mediates the relationship between negative emotionality and information avoidance. The study contributes by showing that personal inclinations impact emotionally motivated information avoidance across contexts.
A Nemzeti Közszolgálati Egyetem Hadtudományi és Honvédtisztképző Kar tudományos és nemzetközi tevékenysége: 2017–2019 1. rész
Creators: name: Pohl, Árpád
name: Jobbágy, Zoltán
Publisher: name: Magyar Hadtudományi Társaság
Year: 2020
Subjects: subject: military science
subject: education
subject: international relations
subject: research and development
subject: hadtudomány
subject: oktatás
subject: nemzetközi kapcsolatok
subject: kutatás-fejlesztés

description: Hadtudomány, vol. 30. Electronic issue., ISSN 1215-4121, eISSN 1588-0605
description: The designation of the Faculty of Military Science and Officer Training is to provide, in line with the dynamically changing security and defence policy challenges, an adequate background for the military science, military technical science, social and natural sciences supporting various tasks related to national defence, and the technical research and development linked to various scientific fields. The Faculty is also to integrate the various conclusions and suggestions coming from general scientific progress and results of scientific research, and it is to produce knowledge that is, at any level of Hungarian officer training, able to meet the demands of the 21st century.
description: A Nemzeti Közszolgálati Egyetem Hadtudományi és Honvédtisztképző Kar alapvető rendeltetése, hogy a dinamikusan változó biztonság- és védelempolitikai kihívásokkal összhangban megfelelő hátteret biztosítson a hadtudomány, a katonai műszaki tudomány, a honvédelmi feladatok ellátását szolgáló társadalom- és természettudományok, a haditechnikai kutatás-fejlesztés más tudományterületekhez való kapcsolódásához, valamint célirányosan integrálja a tudományok általános fejlődéséből és a tudományos kutatások eredményeiből származó következtetéseket, javaslatokat. Mindezzel olyan tudást állítson elő, ami a magyar honvédtisztképzés minden szintjén képes megfelelni a 21. század kihívásainak.
Table S1 from On the relationship between maxillary molar root shape and jaw kinematics in Australopithecus africanus and Paranthropus robustus.
Creators: name: Kupczik, Kornelius
name: Toro-Ibacache, Viviana
name: Macho, Gabriele A.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Fossil sample
Table S2 from On the relationship between maxillary molar root shape and jaw kinematics in Australopithecus africanus and Paranthropus robustus.
Creators: name: Kupczik, Kornelius
name: Toro-Ibacache, Viviana
name: Macho, Gabriele A.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Raw landmark (x,y,z) coordinates for each specimen. 8 landmarks in total
Testing a dissipative kinetic k-essence model
Creators: name: Cardenas, V. H.
name: Cruz, N.
name: Villanueva, J. R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In this work, we present a study of a purely kinetic k-essence model, characterized basically by a parameter $α$ in presence of a bulk dissipative term, whose relationship between viscous pressure $Π$ and energy density $ρ$ of the background follows a polytropic type law $Π\propto ρ^{λ+1/2}$, where $λ$, in principle, is a parameter without restrictions. Analytical solutions for the energy density of the k-essence field are found in two specific cases: $λ=1/2$ and $λ=(1-α)/2α$, and then we show that these solutions posses the same functional form than the non-viscous counterpart. Finally, both approach are contrasted with observational data from type Ia supernova, and the most recent Hubble parameter measurements, and therefore, the best values for the parameters of the theory are founds.
description: 9 pages, 5 figures, accepted in EPJC
Vormoderne Globalgeschichten.
Creators: name: Drews, Wolfram
name: Oesterle, Jenny Rahel
Publisher: name: Leipziger Universitätsverlag
Year: 2008

description: Comparativ, Vol 18 No 3-4 (2008): Transkulturelle Komparatistik. Beiträge zu einer Globalgeschichte der Vormoderne
Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation
Creators: name: Der, Channing J.
name: Baldwin Jr., Albert S.
name: Norris, Jacqueline L.
name: Beg, Amer A.
name: Westwick, John K.
name: Finco, Timothy S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Ras proteins function in stimulating cell proliferation and differentiation through the activation of Raf-dependent and Raf-independent signal transduction pathways and the subsequent activation of specific transcription factors. The transcription factor NF-kappaB has been widely studied as a regulator of genes involved in immune and inflammatory responses. A variety of stimuli activate NF-kappaB through the induced phosphorylation and degradation of the inhibitor IkappaB followed by nuclear translocation of NF-kappaB. We show here that oncogenic forms of Ha-Ras activate NF-kappaB, not through induced nuclear translocation, but rather through the activation of the transcriptional function of the NF-kappaB RelA/p65 subunit. Importantly, RelA/p65 -/- cells are inefficient in the activation of kappaB-dependent gene expression in response to oncogenic Ras expression. Furthermore, IkappaBalpha expression blocks focus formation in NIH3T3 cells induced by oncogenic Ras. These results demonstrate that NF-kappaB is a critical downstream mediator of Ha-Ras signaling and oncogenic potential.
Universality of corner entanglement in conformal field theories
Creators: name: Bueno, Pablo
name: Myers, Robert C.
name: Witczak-Krempa, William
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the contribution to the entanglement entropy of (2+1)-dimensional conformal field theories coming from a sharp corner in the entangling surface. This contribution is encoded in a function $a(θ)$ of the corner opening angle, and was recently proposed as a measure of the degrees of freedom in the underlying CFT. We show that the ratio $a(θ)/C_T$, where $C_T$ is the central charge in the stress tensor correlator, is an almost universal quantity for a broad class of theories including various higher-curvature holographic models, free scalars and fermions, and Wilson-Fisher fixed points of the $O(N)$ models with $N=1,2,3$. Strikingly, the agreement between these different theories becomes exact in the limit $θ\rightarrow π$, where the entangling surface approaches a smooth curve. We thus conjecture that the corresponding ratio is universal for general CFTs in three dimensions.
description: 4+7 pages, 2+0 figures, 1+0 tables; v2: minor modifications to match published version, references added
Table S3 from On the relationship between maxillary molar root shape and jaw kinematics in Australopithecus africanus and Paranthropus robustus.
Creators: name: Kupczik, Kornelius
name: Toro-Ibacache, Viviana
name: Macho, Gabriele A.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Centroid size (in mm) and scores of the first three PCs of fossil hominin and great ape M1 root shape
(1967) Harriet Etches
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
p120 GAP Modulates Ras Activation of Jun Kinases and Transformation
Creators: name: Westwick, John K.
name: Clark, Geoffrey J.
name: Der, Channing J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Although recent evidence demonstrates that Ras causes transformation by activation of multiple downstream pathways, the specific role of non-Raf effector pathways is presently unknown. Although Ras causes activation of the Jun NH2-terminal kinases (JNKs) via a Raf-independent pathway, the contribution of JNK activation to Ras transformation and the effector that mediates JNK activation have not been established. We observed that a dominant negative mutant of SEK1/JNKK, an activator of JNKs, selectively inhibited oncogenic Ras activation of JNK and Ras transformation, but not Ras activation of the p42 mitogen-activated protein kinase. In contrast, overexpression of wild type SEK1 enhanced Ras activation of JNK and transforming activity. Thus, JNK activation promotes Ras transformation. Furthermore, a dominant negative mutant of p120 GAP (designated N-GAP), a candidate Ras effector, blocked Ras, but not Raf, transformation and blocked Ras, but not Rac, activation of JNK. Since N-GAP overexpression reduced the association of p190 Rac/Rho GAP with endogenous p120 GAP, N-GAP may form nonproductive complexes with components critical for p120 GAP function. In summary, p120 GAP may function as an effector for Ras activation of JNK and Ras transformation.
Indicative findings from a study of information behaviour in digital business ideation: insights from the developing world
Creators: name: Ibrahim, Suraj
name: Marcella, Rita
name: McLennan, Alan
Publisher: name: Humboldt-Universität zu Berlin
Year: 2022
Subjects: subject: Ideation
subject: Information
subject: Digital Entrepreneurship
subject: Information Behavior
subject: 020 Bibliotheks- und Informationswissenschaften

description: Though a wealth of information behaviour research has been undertaken in various contexts over the years, less has been done on entrepreneurship. In particular, there is a lack of literature around the ideation component in the early stages of business formation. This study seeks to address the theoretical and empirical gap within this research stream, bringing together information, innovation, and creativity theory, as lenses through which to explore the phenomenon. Twelve semi-structured interviews were conducted with business founders. Participants operated in a variety of segments of the digital technology spectrum. Critical Realism and Grounded Theory were used as theoretical and practical data techniques, using abduction in the theoretical redescription of concepts (codes) identified in the empirical data, and retroduction to identify the necessary contextual conditions for a particular causal mechanism to take effect and result in the observed empirical trends. Indicative results show several societal and personal factors play a role in shaping the information behaviour of digital entrepreneurs. These factors include but are not limited to poverty, parenting, and unequal power between mentors and mentees. While this research project is ongoing, early findings emerge in previously unexplored aspects of information behaviour such as the importance of reading passion and early exposure to digital devices amongst digital entrepreneurs.
Paxillin Is Tyrosine-phosphorylated by and Preferentially Associates with the Calcium-dependent Tyrosine Kinase in Rat Liver Epithelial Cells
Creators: name: Li, Xiong
name: Earp, H. Shelton
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: We and others have recently cloned a non-receptor, calcium-dependent tyrosine kinase (CADTK; also known as PYK2, CAKbeta, and RAFTK) that shares both overall domain structure and 45% amino acid identity with p125(FAK). We have studied the signaling, activation, and potential function of these related enzymes in GN4 rat liver epithelial cells that express CADTK and p125(FAK) at roughly similar levels. p125(FAK) is nearly fully tyrosine-phosphorylated in resting GN4 cells. In contrast, while CADTK is not tyrosine-autophosphorylated in untreated cells, angiotensin II increases CADTK Tyr(P) by 5-10-fold. With regard to signaling, CADTK activation is correlated with stimulation of c-Jun N-terminal kinase and p70(S6K) pathways but not with the stimulation of mitogen-activated protein kinase or p90(RSK). In this report we assessed the contribution of CADTK and p125(FAK) to tyrosine phosphorylation of focal contact proteins. In adherent GN4 cells, the constitutive activity of p125(FAK) was correlated with basal paxillin, tensin, and p130(CAS) tyrosine phosphorylation. A rapid increase in the tyrosine phosphorylation of each protein was detected after treatment with angiotensin II or other agonists that stimulate CADTK; the prolonged 3-4-fold increase in paxillin tyrosine phosphorylation was the most substantial change. In the WB cell line that expresses 3-fold less CADTK than GN4 cell line agonist-dependent paxillin tyrosine phosphorylation is similarly reduced. Immunoprecipitation of CADTK from GN4 cells revealed CADTK. paxillin complexes that persisted in 500 mM NaCl but not in 0.1% SDS cell lysis buffer. The complexes were largely independent of the tyrosine phosphorylation state of either protein. Surprisingly, we did not detect p125(FAK).paxillin complexes in immunoprecipitates using either of two p125(FAK) antibodies. When CADTK and p125(FAK) were transiently overexpressed in 293(T) cells, both enzymes associated with paxillin, but the avidity of CADTK appeared to be greater. In addition, in transfected 293(T) cells, complexes between CADTK and another potential substrate, p130(CAS), were detected. In summary, in GN4 rat liver epithelial cells stimulation of CADTK was highly correlated with paxillin tyrosine phosphorylation; in addition, CADTK but not p125(FAK) was complexed to paxillin at detectable levels. This suggests that agonist-dependent cytoskeletal changes in epithelial cells might proceed, in part, by CADTK-dependent mechanisms.
(1968) Joseph Boddy
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A classification of spherical conjugacy classes
Creators: name: Costantini, Mauro
Publisher: name: arXiv
Year: 2015
Subjects: subject: Group Theory (math.GR)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: Let G be a simple algebraic group over an algebraically closed field k. We classify the spherical conjugacy classes of G.
description: 36 pages