cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Definition and clinical validation of Pain Patient States from high-dimensional mobile data: application to a chronic pain cohort
Creators: name: Reinen, Jenna M.
name: Agurto, Carla
name: Cecchi, Guillermo
name: Rogers, Jeffrey L.
name: NAVITAS
name: Group, ENVISION Studies Physician Author
name: Consortium, Boston Scientific Research Scientists
Publisher: name: arXiv
Year: 2023
Subjects: subject: Applications (stat.AP)
subject: Quantitative Methods (q-bio.QM)
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences

description: The technical capacity to monitor patients with a mobile device has drastically expanded, but data produced from this approach are often difficult to interpret. We present a solution to produce a meaningful representation of patient status from large, complex data streams, leveraging both a data-driven approach, and use clinical knowledge to validate results. Data were collected from a clinical trial enrolling chronic pain patients, and included questionnaires, voice recordings, actigraphy, and standard health assessments. The data were reduced using a clustering analysis. In an initial exploratory analysis with only questionnaire data, we found up to 3 stable cluster solutions that grouped symptoms on a positive to negative spectrum. Objective features (actigraphy, speech) expanded the cluster solution granularity. Using a 5 state solution with questionnaire and actigraphy data, we found significant correlations between cluster properties and assessments of disability and quality-of-life. The correlation coefficient values showed an ordinal distinction, confirming the cluster ranking on a negative to positive spectrum. This suggests we captured novel, distinct Pain Patient States with this approach, even when multiple clusters were equated on pain magnitude. Relative to using complex time courses of many variables, Pain Patient States holds promise as an interpretable, useful, and actionable metric for a clinician or caregiver to simplify and provide timely delivery of care.
Additional file 20 of Non-canonical two-step biosynthesis of anti-oomycete indole alkaloids in Kickxellales
Creators: name: Rassbach, Johannes
name: Hilsberg, Nathalie
name: Haensch, Veit G.
name: Dörner, Sebastian
name: Gressler, Julia
name: Sonnabend, Robin
name: Semm, Caroline
name: Voigt, Kerstin
name: Hertweck, Christian
name: Gressler, Markus
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Organic Chemistry
subject: FOS: Chemical sciences

description: Additional file 20: Figure S18. ESI-MS/MS spectrum of 5.
University teachers' digital empowerment for blended teaching: an experience of Teachers’ training in european higher education
Creators: name: Romero, Marc
name: Guitert, Montse
name: Romeu, Teresa
name: Baztán, Pablo
Publisher: name: ECOLHE
Year: 2023

description: Due to the global pandemic, online training became a response for educational institutions to develop their training activities. HE teachers adopted remote solutions based on replicating face-to-face dynamics and activities online, while any online education activity needs a proper design to be developed and to assure students’ meaningful learning. The results were not coherent with online teaching principles, causing a negative vision on online teaching and learning. To promote HE teachers’ Digital Competence, an online course was designed, implemented and evaluated in six European universities. The process of design and implementation will be critically discussed to highlight the limit and opportunities of this training as a model to help teachers to transform their practices to blended teaching.
description: ECOLHE, ECOLHE International Conference Proceedings
Apoptosis and tissue thinning contribute to symmetric cell division in the developing mouse epidermis in a nonautonomous way
Creators: name: Soffer, Arad
name: Williams, Scott E.
name: Adir, Orit
name: Luxenburg, Chen
name: Mahly, Adnan
name: Padmanabhan, Krishnanand
name: Loushi, Eidan
name: Fuchs, Yaron
name: Cohen, Jonathan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Mitotic spindle orientation (SO) is a conserved mechanism that governs cell fate and tissue morphogenesis. In the developing epidermis, a balance between self-renewing symmetric divisions and differentiative asymmetric divisions is necessary for normal development. While the cellular machinery that executes SO is well characterized, the extrinsic cues that guide it are poorly understood. Here, we identified the basal cell adhesion molecule (BCAM), a β1 integrin coreceptor, as a novel regulator of epidermal morphogenesis. In utero RNAi-mediated depletion of Bcam in the mouse embryo did not hinder β1 integrin distribution or cell adhesion and polarity. However, Bcam depletion promoted apoptosis, thinning of the epidermis, and symmetric cell division, and the defects were reversed by concomitant overexpression of the apoptosis inhibitor Xiap. Moreover, in mosaic epidermis, depletion of Bcam or Xiap induced symmetric divisions in neighboring wild-type cells. These results identify apoptosis and epidermal architecture as extrinsic cues that guide SO in the developing epidermis.
Stability analysis of supermassive primordial stars: a new mass range for general relativistic instability supernovae
Creators: name: Nagele, Chris
name: Umeda, Hideyuki
name: Takahashi, Koh
name: Yoshida, Takashi
name: Sumiyoshi, Kohsuke
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Observed supermassive black holes in the early universe have several proposed formation channels, in part because most of these channels are difficult to probe. One of the more promising channels, the direct collapse of a supermassive star, has several possible probes including the explosion of a helium-core supermassive star triggered by a general relativistic instability. We develop a straightforward method for evaluating the general relativistic radial instability without simplifying assumptions and apply it to population III supermassive stars taken from a post Newtonian stellar evolution code. This method is more accurate than previous determinations and it finds that the instability occurs earlier in the evolutionary life of the star. Using the results of the stability analysis, we perform 1D general relativistic hydrodynamical simulations and we find two general relativistic instability supernovae fueled by alpha capture reactions as well as several lower mass pulsations, analogous to the puslational pair instability process. The mass range for the events (2.6-3.0 $\times 10^4$ ${\rm M}_\odot$) is lower than had been suggested by previous works (5.5 $\times 10^4$ ${\rm M}_\odot$) because the instability occurs earlier in the star's evolution. The explosion may be visible to, among others, JWST, while the discovery of the pulsations opens up additional possibilities for observation.
Πιστοποίηση προϊόντων δομικού χάλυβα
Creators: name: Vogiatzis, Tzanetis
Publisher: name: Zenodo
Year: 2012
Subjects: ΜΕΤΑΛΛΙΚΕΣ ΚΑΤΑΣΚΕΥΕΣ
ΣΙΔΗΡΕΣ ΚΑΤΑΣΚΕΥΕΣ
ΚΑΤΑΣΚΕΥΕΣ ΑΠΟ ΔΟΜΙΚΟ ΧΑΛΥΒΑ
ΕΥΡΩΚΩΔΙΚΑΣ 3
ΔΟΜΙΚΑ ΣΤΟΙΧΕΙΑ ΧΑΛΥΒΑ

description: Η Ευρωπαϊκή Επιτροπή για θέματα Επιχειρήσεων και Βιομηχανίας εισάγει με την οδηγία 89/106/EEC κατευθυντήριες
 οδηγίες των προδιαγραφούν που θα πρέπει να πληρούν τα δομικά προϊόντα. Σκοπός αυτής της οδηγίας είναι να εξασφαλίσει την ελεύθερη διακίνηση των δομικών προϊόντων μέσα στην Ευρωπαϊκή Ένωση εναρμονίζοντας τις σχετικές νομοθεσίες της κάθε χώρας ως προς τις θεμελιώδης απαιτήσεις Υγείας και Ασφάλειας των προϊόντων. Στην Ελλάδα ψηφίστηκε στις 15/06/2012 το ΦΕΚ 1914/Β/2012 θέτοντας έτσι ένα νόμο πάνω στα προϊόντα Δομικών Κατασκευών ο οποίος συμπεριλαμβάνει χαρακτηριστικά, τεχνικές προδιαγραφές, διαδικασίες αξιολόγησης συμμόρφωσης και σήμανση συμμόρφωσης CE.
Online teaching in higher education after the pandemic experience: guidelines and recomendations. Conclusions from the pandemic era experience
Creators: name: Stylianakis, Vassilios
name: Perivolaris, Panagiotis
Publisher: name: ECOLHE
Year: 2023

description: In the years during the pandemic, there was a dramatic conversion in the traditional operation of universities. Until then, distant teaching was used rarely, or not at all. To fulfill their role and continue their operation in quarantine times, traditional Higher Education Institutes (HEIs) transformed their teaching services from in situ into fully distant, keeping it this way for at least two years. A critical question is whether they should return to their usual teaching methods or transform their operation, based on their experience from distant teaching. The present work uses the collective work of ECOLHE Project to outline the effect of new teaching methods in Higher Education (HE) during and after the pandemic. During a three-year research, ECOLHE project investigates the way that Universities have forwarded the enhancing of ICT resources in HE, through the realization of six case studies in partner countries HEIs. Furthermore, the Project developed a pilot implementation of an online environment as an online teaching tool to increase HE teachers’ ability in the usage of digital technologies. Next step was the creation of a Serious Game aiming to study users’ development of new skills and new ways of solving problems. Also, a self-assessment tool was implemented aiming to define and evaluate the level of innovation in HE institutes. Summarizing the extensive work of the previous steps conclusions were drawn that lead to the formation of Recommendations and Guidelines regarding the Academic Bodies, with the target of addressing the challenges for modern educational systems.
description: ECOLHE, ECOLHE International Conference Proceedings
Microbiology Laboratory Benchspace Literacy: Gigapan Imaging Enhancing Linguistic Landscape Research
Creators: name: Hanauer, David L.
Publisher: name: Figshare
Year: 2018
Subjects: subject: 80106 Image Processing
subject: FOS: Computer and information sciences

description: The aim of this brief paper is to report on research that utilized Gigapan imaging technology to explore the usage of literacy in the benchspace of a microbiology laboratory. The paper addressed the following questions: 1)What genres are used in the bench space of a microbiology laboratory? 2)What are the functions of these genres within the microbiology laboratory? Results revealed a range of genres within the laboratory benchspace environment that fulfilled four functions: 1) Presentation of Visual Data; 2) Presentation of Procedural Information; 3) Constructing and Announcing Personal and Social Identity; & 4) Personalizing Science. These functions fulfilled the aims of conducting laboratory research and constructing personal, social and professional connections.
What Happens at Surfaces and Grain Boundaries of Halide Perovskites: Insights from Reactive Molecular Dynamics Simulations of CsPbI$_{3}$
Creators: name: Pols, Mike
name: Hilpert, Tobias
name: Filot, Ivo
name: van Duin, Adri C. T.
name: Calero, Sofía
name: Tao, Shuxia
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The commercialization of perovskite solar cells is hindered by the poor long-term stability of the metal halide perovskite (MHP) light absorbing layer. Solution processing, the common fabrication method for MHPs, produces polycrystalline films with a wide variety of defects, such as point defects, surfaces, and grain boundaries. Although the optoelectronic effects of such defects have been widely studied, the evaluation of their impact on the long-term stability remains challenging. In particular, an understanding of the dynamics of degradation reactions at the atomistic scale is lacking. In this work, using reactive force field (ReaxFF) molecular dynamics simulations, we investigate the effects of defects, in the forms of surfaces, surface defects and grain boundaries, on the stability of the inorganic halide perovskite CsPbI$_{3}$. Our simulations establish a stability trend for a variety of surfaces, which correlates well with the occurrence of these surfaces in experiments. We find that a perovskite surface degrades by progressively changing the local geometry of PbI$_{\mathrm{x}}$ octahedra from corner- to edge- to face-sharing. Importantly, we find that Pb dangling bonds and the lack of steric hindrance of I species are two crucial factors that induce degradation reactions. Finally, we show that the stability of these surfaces can be modulated by adjusting their atomistic details, either by creating additional point defects or merging them to form grain boundaries. While in general additional defects, particularly when clustered, have a negative impact on the material stability, some grain boundaries have a stabilizing effect, primarily because of the additional steric hindrance.
description: 29 pages, 7 figures
Point sets with many non-crossing matchings
Creators: name: Asinowski, Andrei
name: Rote, Günter
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computational Geometry (cs.CG)
subject: Discrete Mathematics (cs.DM)
subject: Combinatorics (math.CO)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: The maximum number of non-crossing straight-line perfect matchings that a set of $n$ points in the plane can have is known to be $O(10.0438^n)$ and $Ω^*(3^n)$. The lower bound, due to García, Noy, and Tejel (2000) is attained by the double chain, which has $Θ(3^n n^{O(1)})$ such matchings. We reprove this bound in a simplified way that uses the novel notion of down-free matching, and apply this approach on several other constructions. As a result, we improve the lower bound. First we show that double zigzag chain with $n$ points has $Θ^*(λ^n)$ such matchings with $λ\approx 3.0532$. Next we analyze further generalizations of double zigzag chains - double $r$-chains. The best choice of parameters leads to a construction with $Θ^*(ν^n)$ matchings, with $ν\approx 3.0930$. The derivation of this bound requires an analysis of a coupled dynamic-programming recursion between two infinite vectors.
description: 33 pages, 19 figures, 2 tables
Quantum Hairy Black Hole Formation and Horizon Quantum Mechanics
Creators: name: Cavalcanti, R. T.
name: da Silva, J. M. Hoff
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: After introducing the gravitational decoupling method and the hairy black hole recently derived from it, we investigate the formation of quantum hairy black holes by applying the horizon quantum mechanics formalism. It enables us to determine how external fields, characterized by hairy parameters, affect the probability of spherically symmetric black hole formation and the generalized uncertainty principle.
description: 10 pages, 5 figures
Phase Characters of Optical Dark Solitons with the Third-order Dispersion and Delayed Nonlinear Response
Creators: name: Qin, Yan-Hong
name: Zhang, Xiaoman
name: Ling, Liming
name: Zhao, Li-Chen
Publisher: name: arXiv
Year: 2022
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: Dark soliton is usually seen as one of the simplest topological solitons, due to the phase jump across its density dip. We investigate the phase jump properties of dark solitons in a single mode optical fiber with the third-order dispersion and delayed nonlinear response, based on exact analytical solutions of Hirota equation. Our analysis indicates that a single-valley dark soliton (SVDS) can admit two distinct phase jumps at the same velocity, in sharp contrast to the dark soliton with only the second-order dispersion and self-phase modulation, which admits a one-to-one match between the velocity and phase jump. We further uncover the different topological vector potentials underlying the distinct phase jumps. The relations between phase jump and velocity of the SVDS can explain the generation of the previously reported double-valley dark soliton (DVDS). The detailed analysis on the two phase jumps characters of the DVDS with one identical velocity enables us to obtain U-shaped type or double-step type phase distribution. We further explore collision properties of the DVDSs by analyzing their topological phase, which can be considered as the generalization of topological phase (Phys. Rev. E 103, L040204). Strikingly, the inelastic collision can lead to the conversion between the two types of phase distributions for DVDS. The results reveal that inelastic or elastic collision can be judged by analyzing the magnetic monopole fields.
description: 15 pages, 7 figures
Development and design of the first structured clinic-based program in lower resource settings to transition emerging adults with type 1 diabetes from pediatric to adult care
Creators: name: Praveen, Pradeep A.
name: Peerzada, Ariba
name: Tandon, Nikhil
name: Goyal, Alpesh
name: Sarteau, Angelica Cristello
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Introduction Type 1 diabetes (T1D) is increasing in young people worldwide and more children in resource limited settings are living into adulthood. There is a need for rigorous testing and reporting of evidence-based and stakeholder-informed strategies that transition individuals with T1D from pediatric to adult care. We present the development of and design of the first structured transition program in Delhi, India, to inform similar efforts in India and resource limited settings. Methods The intervention development team included clinicians and researchers with expertise in T1D and the implementation context. To select intervention outcomes, establish intervention targets, and design session modules, we drew upon formative research conducted at prospective intervention implementation sites, consensus guidelines, and previous care transition and behavior change research conducted in developed settings. We used the Template for Intervention Description and Replication and GUIDance for the rEporting of intervention Development checklists to report the intervention and development process. Results The 15-month program (“PATHWAY”) includes five quarterly ~30 minute sessions delivered predominantly by diabetes educators at pediatric and adult clinics, which coincide with routine care visits. Primary program components include educational and behavioral sessions that address psychosocial drivers of clinic attendance and self-management, diabetes educators as transition coordinators and counselors, and a one-year “overlap period” of alternating visits between pediatric and adult providers. Conclusions We followed a systematic and transparent process to develop PATHWAY, which facilitated rich description of intervention context, guiding principles, targets, and components. Dependence on previously published program examples to design PATHWAY may have introduced challenges for program feasibility and effectiveness, underscoring the importance of input gathering from prospective intervention actors at multiple points in the development process. This detailed report in combination with future evaluations of PATHWAY support efforts to increase rigorous development and testing of strategies to improve outcomes among emerging adults with T1D.
Dynamical essence of the eccentric von Zeipel-Lidov-Kozai effect in restricted hierarchical planetary systems
Creators: name: Lei, Hanlun
name: Gong, Yan-Xiang
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Aim. The eccentric von Zeipel-Lidov-Kozai (ZLK) effect is widely used to explain dynamical phenomena in varieties of astrophysical systems. The purpose of this work is to make clear the dynamical essence of the eccentric ZLK effect by constructing an inherent connection between such an effect and dynamics of secular resonance in restricted hierarchical planetary systems. Methods. Dynamical structures of apsidal resonance are analytically studied by means of perturbative treatments. The resonant model is formulated by averaging the Hamiltonian (up to octupole order) over rotating ZLK cycles, producing an additional motion integral. The phase portraits under the resonant model can be used to analyse dynamical structures, including resonant centres, dynamical separatrices and islands of libration. Results. By analysing phase portraits, five branches of libration centres and eight libration zones are found in the eccentricity--inclination space. There is an excellent agreement between analytical results of libration zone and numerical distributions of resonant orbit, indicating that the resonant model for apsidal resonances is valid and applicable. Additionally, it is found that, in the test-particle limit, distributions of flipping orbits are dominated by those apsidal resonances centred at the inclination of i = 90 deg. Conclusions. The eccentric ZLK effect is dynamically equivalent to the effect of apsidal resonance in restricted hierarchical planetary systems. The dynamical response of the eccentric ZLK effect (or effect of apsidal resonance) is to significantly excite eccentricities and/or inclinations of test particles in the very long-term evolution.
description: 11 pages, 10 figures. Accepted for publication in A&A
Adopting gamification as a strategy to support students’ motivation in Higher Education: the teachers’ role
Creators: name: Marinensi, Giada
name: Di Lallo, Matilde
name: Botte, Brunella
Publisher: name: ECOLHE
Year: 2023

description: Students' academic performance and learning outcomes are significantly influenced by their level of engagement in learning activities and their motivation to learn. Several studies referred to gamification as a possible strategy to foster students’ engagement and motivation at the Higher Education (HE) level. However, a crucial factor affecting the adoption and the success of this new pedagogical practice is the fact that teachers possess the needed skills’ set to implement it. To equip teachers with the competences needed to effectively design, implement, and evaluate a gamified learning activity, an online course was prepared and piloted in the framework of the European project ECOLHE. This work will offer an analysis of the course design process and a synthesis of the course implementation results.
description: ECOLHE, ECOLHE International Conference Proceedings
Internet of Things: Digital Footprints Carry A Device Identity
Creators: name: Chowdhury, Rajarshi Roy
name: Idris, Azam Che
name: Abas, Pg Emeroylariffion
Publisher: name: arXiv
Year: 2023
Subjects: subject: Machine Learning (cs.LG)
subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: The usage of technologically advanced devices has seen a boom in many domains, including education, automation, and healthcare; with most of the services requiring Internet connectivity. To secure a network, device identification plays key role. In this paper, a device fingerprinting (DFP) model, which is able to distinguish between Internet of Things (IoT) and non-IoT devices, as well as uniquely identify individual devices, has been proposed. Four statistical features have been extracted from the consecutive five device-originated packets, to generate individual device fingerprints. The method has been evaluated using the Random Forest (RF) classifier and different datasets. Experimental results have shown that the proposed method achieves up to 99.8% accuracy in distinguishing between IoT and non-IoT devices and over 97.6% in classifying individual devices. These signify that the proposed method is useful in assisting operators in making their networks more secure and robust to security breaches and unauthorized access.
description: 8th Brunei International Conference on Engineering and Technology (BICET 2021), Universiti Teknologi Brunei
An Exploration of Knowledge and Skills Transfer from a Formal Software Engineering Curriculum to a Capstone Practicum Project
Creators: name: Bareiss, Ray
name: Katz, Ed
Publisher: name: Figshare
Year: 2018
Subjects: subject: Computer Engineering
subject: 80309 Software Engineering
subject: FOS: Computer and information sciences

description: Students at Carnegie Mellon Silicon Valley complete a team-based practicum project for an
industrial sponsor as the capstone of their master’s education in software engineering. Over
time, the faculty member who typically serves as advisor for such projects has been disturbed
by the failure of several student teams to transfer some relevant knowledge and skills from the
formal curriculum to the relatively unstructured practicum project environment. We conducted
a survey of all 2010 software engineering students to ascertain the most significant selfreported
shortcomings. This paper presents the survey data and then discusses the results in
terms of a theory of transfer; as part of this discussion recent and possible future changes to
instruction are identified.
Molybdenum-Rhenium alloy based high-$Q$ superconducting microwave resonators
Creators: name: Singh, Vibhor
name: Schneider, Ben H.
name: Bosman, Sal J.
name: Merkx, Evert P. J.
name: Steele, Gary A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Superconducting microwave resonators (SMR) with high quality factors have become an important technology in a wide range of applications. Molybdenum-Rhenium (MoRe) is a disordered superconducting alloy with a noble surface chemistry and a relatively high transition temperature. These properties make it attractive for SMR applications, but characterization of MoRe SMR has not yet been reported. Here, we present the fabrication and characterization of SMR fabricated with a MoRe 60-40 alloy. At low drive powers, we observe internal quality-factors as high as 700,000. Temperature and power dependence of the internal quality-factors suggest the presence of the two level systems from the dielectric substrate dominating the internal loss at low temperatures. We further test the compatibility of these resonators with high temperature processes such as for carbon nanotube CVD growth, and their performance in the magnetic field, an important characterization for hybrid systems.
description: 12 pages, 4 figures and Supplementary Material
Why Capitalism?
Creators: name: Meltzer, Allan
Publisher: name: Figshare
Year: 2018
Subjects: subject: 150399 Business and Management not elsewhere classified
subject: FOS: Economics and business

description: Newspaper headlines during the peak of the housing-credit crisis called it “the end of capitalism” or the end of American capitalism. As often, they greatly over stated and misstated by projecting a serious, temporary decline as a permanent loss of wealth. Capitalist systems have weathered many more serious problems.
Capitalism as a guiding system for economic activity has spread over the centuries to now encompass most of the world’s economies. This spread occurred despite almost continuous hostility from many intellectuals and, in recent decades, military threat from avowedly Communist countries.
A student-centric working-life competence development a journey from classroom teaching towards ‘onlife’ learning: pedagogical best Practices
Creators: name: Rathod, Paresh
name: Kämppi, Pasi
Publisher: name: ECOLHE
Year: 2023

description: In recent years the digital transformation and pandemic emergency demanded the digitalisation of contemporary higher education (HEIs) in Europe. The situation needs transformational vision, legislative and operational support from the HEI stakeholders, government, and relevant bodies. However, the most critical element is a working-life, and the industry demands a new set of skills and competencies from HEIs graduates. The ECOLHE European innovation project presented the Onlife Manifesto for being human in the hyperconnected world. More broadly, it helps start a reflection on how a hyperconnected world calls for rethinking the many existing practices in HEIs. On the one hand, the hyperconnected world demands a new way of future competencies. And on the other hand, many research studies confirm that a clear gap between HEIs competence development and market demands resulted in a significant shortfall of the workforce and working-life-ready graduates. The most interesting thing in these studies shows the lack of suitable working-life candidates causing this shortfall rather than the organisation’s willingness to hire. In Finland, the education ministry has manifested future-proofing of the education system to meet the demand of modern businesses and a hyperconnected world under the Vision 2030 development. In Vision 2030, one of the key development areas identified was a modern curriculum design and development that meets the rapidly changing demands of working life and society. Laurea University of Applied Sciences has positioned its education offering to fill the gap demand gap and towards Vision 2030. Laurea adopted online education and an innovative pedagogical model that strengthens students’ futureproof competence development and workforce capacity building. A student-centric working-life competence development, a journey from classroom teaching towards 'Onlife' learning presents the pedagogical best practices. The paper focuses on the adaptation of continued curricula development, adopting modern online pedagogical and education approaches, and increasing industry cooperation and work-life practices. The paper addresses two-fold challenges, including meeting the demands of working-life professionals and futureproofing education offerings.
description: ECOLHE, ECOLHE International Conference Proceedings
Small Solutions of Quadratic Congruences, and Character Sums with Binary Quadratic Forms
Creators: name: Heath-Brown, D. R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: Let $Q(x,y,z)$ be an integral quadratic form with determinant coprime to some modulus $q$. We show that $q\mid Q$ for some non-zero integer vector $(x,y,z)$ of length $O(q^{5/8+\varepsilon})$, for any fixed $\varepsilon>0$. Without the coprimality condition on the determinant one could not achieve an exponent below $2/3$. The proof uses a bound for short character sums involving binary quadratic forms, which extends a result of Chang.
Determination of Multi-mode Motional Quantum States in a Trapped Ion System
Creators: name: Jia, Zhubing
name: Wang, Ye
name: Zhang, Bichen
name: Whitlow, Jacob
name: Fang, Chao
name: Kim, Jungsang
name: Brown, Kenneth R.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Trapped atomic ions are a versatile platform for studying interactions between spins and bosons by coupling the internal states of the ions to their motion. Measurement of complex motional states with multiple modes is challenging, because all motional state populations can only be measured indirectly through the spin state of ions. Here we present a general method to determine the Fock state distributions and to reconstruct the density matrix of an arbitrary multi-mode motional state. We experimentally verify the method using different entangled states of multiple radial modes in a 5-ion chain. This method can be extended to any system with Jaynes-Cummings type interactions.
description: 11 pages, 8 figures
Differential microRNA profiles of intramuscular and secreted extracellular vesicles in human tissue-engineered muscle
Creators: name: Bursac, Nenad
name: Truskey, George A.
name: Vann, Christopher G
name: Khodabukus, Alastair
name: Corcoran, David L.
name: Chen, Yu-Hsiu
name: Kraus, Virginia B.
name: Orenduff, Melissa C.
name: Zhang, Xin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Exercise affects the expression of microRNAs (miR/s) and muscle-derived extracellular vesicles (EVs). To evaluate sarcoplasmic and secreted miR expression in human skeletal muscle in response to exercise-mimetic contractile activity, we utilized a three-dimensional tissue-engineered model of human skeletal muscle (“myobundles”). Myobundles were subjected to three culture conditions: no electrical stimulation (CTL), chronic low frequency stimulation (CLFS), or intermittent high frequency stimulation (IHFS) for 7 days. RNA was isolated from myobundles and from extracellular vesicles (EVs) secreted by myobundles into culture media; miR abundance was analyzed by miRNA-sequencing. We used edgeR and a within-sample design to evaluate differential miR expression and Pearson correlation to evaluate correlations between myobundle and EV populations within treatments with statistical significance set at p < 0.05. Numerous miRs were differentially expressed between myobundles and EVs; 116 miRs were differentially expressed within CTL, 3 within CLFS, and 2 within IHFS. Additionally, 25 miRs were significantly correlated (18 in CTL, 5 in CLFS, 2 in IHFS) between myobundles and EVs. Electrical stimulation resulted in differential expression of 8 miRs in myobundles and only 1 miR in EVs. Several KEGG pathways, known to play a role in regulation of skeletal muscle, were enriched, with differentially overrepresented miRs between myobundle and EV populations identified using miEAA. Together, these results demonstrate that in vitro exercise-mimetic contractile activity of human engineered muscle affects both their expression of miRs and number of secreted EVs. These results also identify novel miRs of interest for future studies of the role of exercise in organ-organ interactions in vivo.
The European students’ perspective of digital teaching and learning in Higher Education
Creators: name: Capogna, Stefania
name: De Angelis, Maria Chiara
name: Greco, Francesca
name: Musella, Flaminia
Publisher: name: ECOLHE
Year: 2023

description: The increase in the use of online training connected to the pandemic emergency has highlighted, as never before, that Higher Education Institutions have to deal with the digital revolution, promoted by the European Community since 1998 from the so-called Bologna Process. This work illustrates the results of the students’ survey of the “Empower Competences for Onlife Learning in Higher Education” (ECOLHE) project. the project aimed to investigate the transformation processes and of developing practices of higher education’s digital teaching and learning in several European countries. The research project was based on the hypothesis that the availability of technological infrastructures does not grant an efficient and effective use of ICTs by professors, students, and researchers.
description: ECOLHE, ECOLHE International Conference Proceedings
The Symbiotic Learning Paradigm (SLP): A Learner-Centred Curriculum Design Approach
Creators: name: McCarthy, Finola
name: Ó Tuama, Séamus
Publisher: name: ECOLHE
Year: 2023

description: The Symbiotic Learning Paradigm (SLP) has developed from practice in the Centre for Adult Continuing Education at University College Cork (UCC). Central to this practice are the core concepts of ‘Learner at the Centre’ and ‘Lifelong and Life-wide Learning.’ SLP offers a curriculum design approach that is dynamic and adaptive for the rapidly changing and perpetually challenging world of twenty-first teaching and learning in higher education. It offers a new curriculum design lens that places the learner at the centre and focuses on the importance of collaborative co-designing relationships within and beyond the university as a means to achieve this. Life-wide learning recognises that people occupy different learning spaces (personal, professional, public, community) and the lifelong learning journey provides the learner with a variety of learning experiences (Jackson, 2012). SLP offers a flexible and reflexive approach to co-designing these varied learning experiences. As part of the Erasmus+ ECOLHE Project: Empowering Competencies in ‘Onlife’ Learning, SLP was piloted in six higher education contexts across Europe. Through this process SLP has been developed and refined as a model of best practice and as evidence-based critical reflection on practice to improve practice in higher education. Its process of inquiry into teaching and curriculum design as a ‘practically oriented activity, conducted collegially’ through the ECOLHE project has grounded it in the scholarship of teaching and learning (Prosser, 2008). Through the piloting process of the ECOLHE project we came to understand that the central tenet of the SLP approach to curriculum design is ‘Learner at the Centre’ and so this is the concept that we will discuss here in the ECOLHE final conference paper.
description: ECOLHE, ECOLHE International Conference Proceedings
Cross-sector decision landscape in response to COVID-19: A qualitative network mapping analysis of North Carolina decision-makers
Creators: name: Hecht, Hillary K.
name: Smith, Raymond L.
name: Swann, Julie L.
name: Biddell, Caitlin B.
name: Hassmiller Lich, Kristen
name: Mayorga, Maria E.
name: Johnson, Karl T.
name: Patel, Mehul D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Introduction The COVID-19 pandemic response has demonstrated the interconnectedness of individuals, organizations, and other entities jointly contributing to the production of community health. This response has involved stakeholders from numerous sectors who have been faced with new decisions, objectives, and constraints. We examined the cross-sector organizational decision landscape that formed in response to the COVID-19 pandemic in North Carolina. Methods We conducted virtual semi-structured interviews with 44 organizational decision-makers representing nine sectors in North Carolina between October 2020 and January 2021 to understand the decision-making landscape within the first year of the COVID-19 pandemic. In line with a complexity/systems thinking lens, we defined the decision landscape as including decision-maker roles, key decisions, and interrelationships involved in producing community health. We used network mapping and conventional content analysis to analyze transcribed interviews, identifying relationships between stakeholders and synthesizing key themes. Results Decision-maker roles were characterized by underlying tensions between balancing organizational mission with employee/community health and navigating organizational vs. individual responsibility for reducing transmission. Decision-makers' roles informed their perspectives and goals, which influenced decision outcomes. Key decisions fell into several broad categories, including how to translate public health guidance into practice; when to institute, and subsequently loosen, public health restrictions; and how to address downstream social and economic impacts of public health restrictions. Lastly, given limited and changing information, as well as limited resources and expertise, the COVID-19 response required cross-sector collaboration, which was commonly coordinated by local health departments who had the most connections of all organization types in the resulting network map. Conclusions By documenting the local, cross-sector decision landscape that formed in response to COVID-19, we illuminate the impacts different organizations may have on information/misinformation, prevention behaviors, and, ultimately, health. Public health researchers and practitioners must understand, and work within, this complex decision landscape when responding to COVID-19 and future community health challenges.
Additional file 21 of Non-canonical two-step biosynthesis of anti-oomycete indole alkaloids in Kickxellales
Creators: name: Rassbach, Johannes
name: Hilsberg, Nathalie
name: Haensch, Veit G.
name: Dörner, Sebastian
name: Gressler, Julia
name: Sonnabend, Robin
name: Semm, Caroline
name: Voigt, Kerstin
name: Hertweck, Christian
name: Gressler, Markus
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Organic Chemistry
subject: FOS: Chemical sciences

description: Additional file 21: Table S3. NMR data of 5 in DMSO-d6.
The know-do gap in quality of health for chronic non-communicable diseases in rural China
Creators: name: Ye, Ruixue
name: Meng, Sha
name: Dill, Sarah-Eve
name: Akhtar, Muizz
name: Rozelle, Scott
name: Zhou, Huan
name: Li, Linhua
name: Sylvia, Sean
name: Xue, Hao
name: Wu, Yuju
name: Wang, Qingzhi
name: Pappas, Lucy
name: Chen, Yunwei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Proper management of non-communicable diseases (NCDs) is a severe challenge to China's rural health system. This study investigates what influences the poor medical treatment of NCDs (diabetes and angina) by evaluating the “know-do gap” between provider knowledge and practice. To determine whether low levels of provider knowledge low quality of patient care is the primary constraint on the quality of NCDs diagnosis and treatment in rural China. Providers from Village Clinics (VC) and Township Health Centers (THC), and Standardized Patients (SP) were selected by a multi-stage random sampling method. Clinical vignettes were administered to 306 providers from 103 VCs and 50 THCs in rural Sichuan Province. SPs presented diabetes symptoms completed 97 interactions with providers in 46 VCs and 51 THCs; SPs presented angina symptoms completed 100 interactions with providers in 50 VCs and 50 THCs. Process quality, diagnosis quality, and treatment quality were assessed against national standards for diabetes and angina. Two-tailed T-tests and tests of proportions for continuous outcomes and tests of proportions for binary dependent variables were used to compare vignette and SP results. Differences between vignette and SP data calculated the know-do gap. Regression analyses were used to examine the providers/facility characteristics and knowledge/practice associations. THC providers demonstrated significantly more knowledge in vignettes and better practices in SP visits than VC providers. However, levels of knowledge were low overall: 48.2% of THC providers and 28.2% of VC providers properly diagnosed type 2 diabetes, while 23.8% of THC providers and 14.7% of VC providers properly diagnosed angina. With SPs, 2.1% of THC providers and 6.8% of VC providers correctly diagnosed type 2 diabetes; 25.5% of THC providers and 12.8% of VC providers correctly diagnosed angina. There were significant know-do gaps in diagnosis process quality, diagnosis quality, and treatment quality for diabetes (p < 0.01), and in diagnosis process quality (p < 0.05) and treatment quality for angina (p < 0.01). Providers in rural China display low levels of knowledge when treating diabetes and angina. Despite low knowledge, evidence of the know-do gap indicates that low-quality healthcare is the primary constraint on the quality of NCD diagnosis and treatment in rural China. Our research findings provide a new perspective for the evaluation of the medical quality and a technical basis for the development of new standardized cases in the future.
Type IIB at eight derivatives: insights from Superstrings, Superfields and Superparticles
Creators: name: Liu, James T.
name: Minasian, Ruben
name: Savelli, Raffaele
name: Schachner, Andreas
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the non-linear structure of Type IIB eight-derivative couplings involving the metric and the complexified three-form $G_3$. We show that, at the level of five-point string amplitudes, the kinematics in the maximally R-symmetry-violating sector is fully matched by standard superspace integrals and by superparticle amplitudes in M-theory on a two-torus. The latter approach is used to determine the complete effective action in this sector and to verify its invariance under SL$(2,\mathbb{Z})$ duality. We further comment on the general structure of the higher-point kinematics. Compactifications to lower dimensions provide both tests for our results and the arena for their applications. We verify that K3 reductions are fully consistent with the constraints of six-dimensional supersymmetry, and derive the four-dimensional flux scalar potential and axion kinetic terms at order $(α^{\prime})^{3}$ in Calabi-Yau threefold reductions.
description: 34 pages plus appendices
Age-Layered Expectation Maximization for Parameter Learning in Bayesian Networks
Creators: name: Mengshoel, Ole J
name: Avneesh  Saluja
name: Sundararajan, Priya
Publisher: name: Figshare
Year: 2018
Subjects: subject: Computer Engineering
subject: 80309 Software Engineering
subject: FOS: Computer and information sciences

description: The expectation maximization (EM) algorithm is a popular algorithm for parameter estimation in models with hidden variables. However, the algorithm has several non-trivial limitations, a significant one being variation in eventual solutions found, due to convergence to local optima. Several techniques have been proposed to allay this
problem, for example initializing EM from multiple random starting points and selecting the highest likelihood out of all runs. In this work, we a) show that this method can be very expensive computationally for difficult Bayesian networks, and b) in response we propose an age-layered EM approach (ALEM) that efficiently discards less promising runs well before convergence. Our experiments show a significant  reduction in the number of iterations, typically two- to four-fold, with minimal or no reduction in solution quality, indicating the potential for ALEM to streamline parameter estimation in Bayesian networks.
Assume-Guarantee Abstraction Refinement for Probalistic Systems
Creators: name: Pasareanu, Corina
name: Anvesh  Komuravelli
name: Clark, Edmund M.
Publisher: name: Figshare
Year: 2018
Subjects: subject: Computer Engineering
subject: 80309 Software Engineering
subject: FOS: Computer and information sciences

description: We describe an automated technique for assume-guarantee style checking of strong simulation between a system and a specification, both expressed as non-deterministic Labeled Probabilistic Transition Systems (LPTSes). We first characterize counterexamples to strong simulation as stochastic trees and show that simpler structures are insufficient. Then, we use these trees in an abstraction refinement algorithm that computes the assumptions for assume-guarantee reasoning as conservative LPTS abstractions of some of the system components. The abstractions are automatically refined based on tree counterexamples obtained from failed simulation checks with the remaining components. We have implemented the algorithms for counterexample generation and assume-guarantee abstraction refinement and report encouraging results.
Additional file 22 of Non-canonical two-step biosynthesis of anti-oomycete indole alkaloids in Kickxellales
Creators: name: Rassbach, Johannes
name: Hilsberg, Nathalie
name: Haensch, Veit G.
name: Dörner, Sebastian
name: Gressler, Julia
name: Sonnabend, Robin
name: Semm, Caroline
name: Voigt, Kerstin
name: Hertweck, Christian
name: Gressler, Markus
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Organic Chemistry
subject: FOS: Chemical sciences

description: Additional file 22: Figure S19. GC-MS/MS spectrum of ILA (1).