cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
OpenAIRE guidelines streamlined, modernized and more global
Creators: name: Príncipe, Pedro
name: Vieira, André
name: Pispiringas, Leonidas
Publisher: name: Zenodo
Year: 2024
Subjects: Interoperability guidelines
OpenAIRE
International alignment
metadata standards; harvesting
OR2024

description: The theme of this year's Open Repositories conference, focused on how we can benefit from repositories to empower global progress, drives us to present and discuss the future and new directions of the development of the OpenAIRE Interoperability Guidelines. This presentation aims to present and discuss the recent changes in the guidelines towards its simplification and harmonization, the open issues reported by the community that need to be addressed by the working group and the main components that require a global synchronisation between regional and national repository networks and initiatives.

The OpenAIRE Guidelines play a vital role in OpenAIRE's strategic approach to address the sustainability, openness, and modernization challenges faced by Scholarly Infrastructures, while ensuring enhanced interoperability.

OpenAIRE Guidelines streamlined and modernizedThe OpenAIRE Guidelines are a suite of application profiles designed to allow research performing organisations to make their scholarly outputs visible through the OpenAIRE infrastructure. The profiles are based on established standards and designed to help repository managers expose publications, datasets and CRIS metadata via the OAI-PMH protocol. The OpenAIRE Guidelines have been released for publication repositories, data archives, CRIS systems, software repositories and repositories of other research products.
Materials - The Analysis of Competing Hypotheses in Criminal Investigations
Creators: name: Volbert, Renate
name: Otzipka, Jana
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: The study entitled "The Analysis of Competing Hypotheses in Criminal Investigations" assessed possible benefits of the Analysis of Competing Hypotheses (ACH; Heuer, 1999) as a debiasing technique while counteracting confirmation bias in legal proceedings. In addition, the method's temporal stability was evaluated. This registration contains the materials (i.e. the case vignette including the applied model solution as well as the coding manual used for coding the data; both in German) necessary for the study's replication.
Sinzowia intermedia
Creators: name: Harzhauser, Mathias
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Archaeogastropoda
Trochidae
Sinzowia
Sinzowia intermedia

description: * Sinzowia intermedia (Sinzow, 1877) †
Middle-late Miocene (Bessarabian): Eastern Paratethys (Moldova, Bulgaria, Ukraine, Russia).
(Sladkovskaya 2017)
description: Published as part of Harzhauser, Mathias, 2021, The Cainozoic to present-day record of Circum-Mediterranean, NE Atlantic and North Sea Cantharidinae and Trochinae (Trochoidea, Gastropoda) - a synopsis, pp. 1-81 in Zootaxa 4902 (1) on page 56, DOI: 10.11646/zootaxa.4902.1.1, http://zenodo.org/record/4419088
Sinzowia striatotuberculata
Creators: name: Harzhauser, Mathias
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Archaeogastropoda
Trochidae
Sinzowia
Sinzowia striatotuberculata

description: Sinzowia striatotuberculata (Sinzow, 1875) †
= Phasianella neumayri Sinzow, 1877
Middle-late Miocene (Bessarabian): Eastern Paratethys (Moldova, Bulgaria, Ukraine, Russia).
(Sladkovskaya 2017)
description: Published as part of Harzhauser, Mathias, 2021, The Cainozoic to present-day record of Circum-Mediterranean, NE Atlantic and North Sea Cantharidinae and Trochinae (Trochoidea, Gastropoda) - a synopsis, pp. 1-81 in Zootaxa 4902 (1) on page 56, DOI: 10.11646/zootaxa.4902.1.1, http://zenodo.org/record/4419088
Differences in risk factors for molecular subtypes of clear cell renal cell carcinoma
Creators: name: Chanock, S.J
name: Mates, D
name: Gao, X
name: Troester, M
name: Brennan, P
name: Kirk, E
name: Zaridze, D
name: Sun, X
name: Hakimi, A.A
name: Bencko, V
name: Janout, V
name: Moore, L
name: Furberg, H
name: Linehan, W.M
name: Purdue, M.P
name: Petruzella, S
name: Rhee, J
name: Rothman, N
Publisher: name: John Wiley and Sons Inc
Year: 2021

description: The ccA and ccB molecular subtypes of clear cell renal cell carcinoma (ccRCC) have well-characterized prognostic relevance. However, it is not known whether they possess distinct etiologies. We investigated the relationships between these subtypes and RCC risk factors within a case-control study conducted in Eastern Europe. We analyzed risk factor data for ccA (n = 144) and ccB (n = 106) cases and 1476 controls through case-only and case-control comparisons to assess risk factor differences across subtypes using logistic and polytomous regression models. We also performed a meta-analysis summarizing case-only results from our study and three patient cohorts. Patients with ccB tumors had poorer survival than those with ccA tumors and were more likely to be male (case-only odds ratio [OR] 2.68, 95% confidence interval [CI] 1.43-5.03). In case-control analyses, body mass index was significantly associated with ccA tumors (OR 2.45, 95% CI 1.18-5.10 for ≥35 vs <25 kg/m2) but not with ccB tumors (1.52, 0.56-4.12), while trichloroethylene was associated with ccB but not ccA (OR 3.09, 95% CI 1.11-8.65 and 1.25, 0.36-4.39 respectively for ≥1.58 ppm-years vs unexposed). A polygenic risk score of genetic variants identified from genome-wide association studies was associated with both ccA and, in particular, ccB (OR 1.82, 1.11-2.99 and 2.87, 95% CI 1.64-5.01 respectively for 90th vs 10th percentile). In a meta-analysis of case-only results including three patient cohorts, we still observed the ccB excess for male sex and the ccA excess for obesity. In conclusion, our findings suggest the existence of etiologic heterogeneity across ccRCC molecular subtypes for several risk factors.
Float Shape Optimization of an Oscillating-Body Wave Energy Converter using Heuristic Algorithms
Creators: name: Cen, Y
name: Tan, M
name: Zhang, D
name: Liang, D
Publisher: name: Apollo - University of Cambridge Repository
Year: 2023

description: The focus of improving the economic performance of the oscillating-body wave energy converters (WECs) is the optimization of the float shape. A combination of heuristic algorithms, panel-based hydrodynamic simulations and geometric parameterization forms a potential method to address this challenge. However, previous studies have shown that the optimal float shape depends on the choice of the optimization algorithm and the objective function. To give further insights into the method's effect on the optimal results and enhance its efficiency, the optimization of an oscillating-body WEC with three degrees of freedom (surge, pitch and heave) is considered herewith. The optimization parameters are selected using B-spline surfaces to describe the float geometry in the form of a matrix of control points. Multiple strategies with different heuristic algorithms and objective functions are employed to iteratively optimize the float shape subject to irregular waves. The time-domain boundary element method is used to simulate the interaction between waves and WECs. The numerical and experimental results show that this optimization method can significantly improve the power capture efficiency of the oscillating-body WEC, and both the algorithm setting and the objective function have a great impact on the optimization results.
Race, ethnicity and risk of second primary contralateral breast cancer in the United States
Creators: name: Lynch, C.F
name: Troester, M.A
name: Bandera, E.V
name: Knight, J.A
name: Bernstein, J.L
name: Malone, K.E
name: Palmer, J.R
name: John, E.M
name: Watt, G.P
Publisher: name: John Wiley and Sons Inc
Year: 2021

description: Breast cancer survivors have a high risk of a second primary contralateral breast cancer (CBC), but there are few studies of CBC risk in racial/ethnic minority populations. We examined whether the incidence and risk factors for CBC differed by race/ethnicity in the United States. Women with a first invasive Stage I-IIB breast cancer diagnosis at ages 20-74 years between 2000 and 2015 in the Surveillance, Epidemiology, and End Results Program (SEER) 18 registries were followed through 2016 for a diagnosis of invasive CBC ≥1 year after the first breast cancer diagnosis. We used cause-specific Cox proportional hazards models to test the association between race/ethnicity and CBC, adjusting for age, hormone receptor status, radiation therapy, chemotherapy and stage at first diagnosis, and evaluated the impact of contralateral prophylactic mastectomy, socioeconomic status, and insurance status on the association. After a median follow-up of 5.9 years, 9247 women (2.0%) were diagnosed with CBC. Relative to non-Hispanic (NH) White women, CBC risk was increased in NH Black women (hazard ratio = 1.44, 95% CI 1.35-1.54) and Hispanic women (1.11, 95% CI 1.02-1.20), with the largest differences among women diagnosed at younger ages. Adjustment for contralateral prophylactic mastectomy, socioeconomic status and health insurance did not explain the associations. Therefore, non-Hispanic Black and Hispanic women have an increased risk of CBC that is not explained by clinical or socioeconomic factors collected in SEER. Large studies of diverse breast cancer survivors with detailed data on treatment delivery and adherence are needed to inform interventions to reduce this disparity.
Steromphala adansonii
Creators: name: Harzhauser, Mathias
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Trochida
Trochidae
Steromphala
Steromphala adansonii

description: Steromphala adansonii (Payraudeau, 1826)
Pliocene (Zanclean): Mediterranean Sea (Italy).
Pleistocene: Mediterranean Sea (Italy).
Present-day: Mediterranean Sea, Black Sea.
(Chirli 2004)
description: Published as part of Harzhauser, Mathias, 2021, The Cainozoic to present-day record of Circum-Mediterranean, NE Atlantic and North Sea Cantharidinae and Trochinae (Trochoidea, Gastropoda) - a synopsis, pp. 1-81 in Zootaxa 4902 (1) on page 58, DOI: 10.11646/zootaxa.4902.1.1, http://zenodo.org/record/4419088
Steromphala albida
Creators: name: Harzhauser, Mathias
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Trochida
Trochidae
Steromphala
Steromphala albida

description: Steromphala albida (Gmelin, 1791)
Pliocene (Piacenzian): Mediterranean Sea (Italy).
Pleistocene: Mediterranean Sea (Kos).
Present-day: Mediterranean Sea, Black Sea, Sea of Azov.
(Sacco 1896; Glibert 1962)
description: Published as part of Harzhauser, Mathias, 2021, The Cainozoic to present-day record of Circum-Mediterranean, NE Atlantic and North Sea Cantharidinae and Trochinae (Trochoidea, Gastropoda) - a synopsis, pp. 1-81 in Zootaxa 4902 (1) on page 58, DOI: 10.11646/zootaxa.4902.1.1, http://zenodo.org/record/4419088
Steromphala adriatica
Creators: name: Harzhauser, Mathias
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Trochida
Trochidae
Steromphala
Steromphala adriatica

description: Steromphala adriatica (Philippi, 1844)
Pliocene (Piacenzian): Mediterranean Sea (Italy).
Present-day: Mediterranean Sea, Sea of Azov.
(Glibert 1962)
description: Published as part of Harzhauser, Mathias, 2021, The Cainozoic to present-day record of Circum-Mediterranean, NE Atlantic and North Sea Cantharidinae and Trochinae (Trochoidea, Gastropoda) - a synopsis, pp. 1-81 in Zootaxa 4902 (1) on page 58, DOI: 10.11646/zootaxa.4902.1.1, http://zenodo.org/record/4419088
Proper understanding of recurrent stress urinary incontinence treatment in women (PURSUIT): a randomised controlled trial of endoscopic and surgical treatment.
Creators: name: Clark, L
name: Fitzgerald, B
name: Noble, S
name: MacNeill, S
name: Paramasivan, S
name: Cotterill, N
name: Hashim, H
name: Jha, S
name: Toozs-Hobson, P
name: Greenwell, T
name: Thiruchelvam, N
name: Agur, W
name: White, A
name: Garner, V
name: Cobos-Arrivabene, M
name: Clement, C
name: Cochrane, M
name: Liu, Y
name: Lewis, AL
name: Taylor, J
name: Lane, JA
name: Drake, MJ
name: Pope, C
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Study Protocol
PURSUIT
Recurrent stress urinary incontinence
Endoscopic bulking injections
Surgery
Colposuspension
Autologous fascial sling
Artificial urinary sphincter
Randomised controlled trial
International Consultation on Incontinence Questionnaire – Urinary Incontinence – Short Form (ICIQ-UI-SF)
Qualitative

description: BACKGROUND: Women with stress urinary incontinence (SUI) experience urine leakage with physical activity. Currently, the interventional treatments for SUI are surgical, or endoscopic bulking injection(s). However, these procedures are not always successful, and symptoms can persist or come back after treatment, categorised as recurrent SUI. There are longstanding symptoms and distress associated with a failed primary treatment, and currently, there is no consensus on how best to treat women with recurrent, or persistent, SUI. METHODS: A two-arm trial, set in at least 20 National Health Service (NHS) urology and urogynaecology referral units in the UK, randomising 250 adult women with recurrent or persistent SUI 1:1 to receive either an endoscopic intervention (endoscopic bulking injections) or a standard NHS surgical intervention, currently colposuspension, autologous fascial sling or artificial urinary sphincter. The aim of the trial is to determine whether surgical treatment is superior to endoscopic bulking injections in terms of symptom severity at 1 year after randomisation. This primary outcome will be measured using the patient-reported International Consultation on Incontinence Questionnaire - Urinary Incontinence - Short Form (ICIQ-UI-SF). Secondary outcomes include assessment of longer-term clinical impact, improvement of symptoms, safety, operative assessments, sexual function, cost-effectiveness and an evaluation of patients' and clinicians' views and experiences of the interventions. DISCUSSION: There is a lack of high-quality, randomised, scientific evidence for which treatment is best for women presenting with recurrent SUI. The PURSUIT study will benefit healthcare professionals and patients and provide robust evidence to guide further treatment and improve symptoms and quality of life for women with this condition. TRIAL REGISTRATION: International Standard Randomised Controlled Trials Number (ISRCTN) registry ISRCTN12201059. Registered on 09 January 2020.
Development of a student-driven undergraduate program in regenerative medicine.
Creators: name: W Sandoval, Aaron Gabriel
name: Traktuev, Dmitry O
name: March, Keith L
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Special Report
education
healthcare
next generation
pipeline
regenerative medicine
training
translation
undergraduate

description: As it begins to enter the clinic, regenerative medicine has the potential to revolutionize healthcare. Although there exists a growing need for individuals well-versed in the practice of regenerative medicine, few undergraduate institutions offer opportunities to learn about the topic. This article highlights the conception of two novel undergraduate courses in regenerative medicine developed through collaboration between students and faculty at our University to fill this void in the undergraduate curriculum. Lectures from scientists, healthcare professionals, regulatory experts and biotechnology leaders introduced students to regenerative medicine research and the translational process, and a certificate program incorporating relevant coursework and research experience is in development. This pipeline will guide promising undergraduate students to the field of regenerative medicine.
Steromphala brevispira
Creators: name: Harzhauser, Mathias
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Trochida
Trochidae
Steromphala
Steromphala brevispira

description: Steromphala brevispira (Harmer, 1923) †
Pliocene (Zanclean): North Sea (British Isles).
(Harmer 1923)
description: Published as part of Harzhauser, Mathias, 2021, The Cainozoic to present-day record of Circum-Mediterranean, NE Atlantic and North Sea Cantharidinae and Trochinae (Trochoidea, Gastropoda) - a synopsis, pp. 1-81 in Zootaxa 4902 (1) on page 58, DOI: 10.11646/zootaxa.4902.1.1, http://zenodo.org/record/4419088
A Validated Risk Prediction Model for Breast Cancer in US Black Women
Creators: name: Bernstein, L
name: Ambrosone, C.B
name: Rosenberg, L
name: Troester, M.A
name: Pfeiffer, R.M
name: Bandera, E.V
name: Palmer, J.R
name: Trinquart, L
name: Bertrand, K.A
name: Zirpoli, G
name: Battaglia, T
Publisher: name: Lippincott Williams and Wilkins
Year: 2021

description: PURPOSE Breast cancer risk prediction models are used to identify high-risk women for early detection, targeted interventions, and enrollment into prevention trials. We sought to develop and evaluate a risk prediction model for breast cancer in US Black women, suitable for use in primary care settings. METHODS Breast cancer relative risks and attributable risks were estimated using data from Black women in three US population-based case-control studies (3,468 breast cancer cases; 3,578 controls age 30-69 years) and combined with SEER age- and race-specific incidence rates, with incorporation of competing mortality, to develop an absolute risk model. The model was validated in prospective data among 51,798 participants of the Black Women’s Health Study, including 1,515 who developed invasive breast cancer. A second risk prediction model was developed on the basis of estrogen receptor (ER)–specific relative risks and attributable risks. Model performance was assessed by calibration (expected/observed cases) and discriminatory accuracy (C-statistic). RESULTS The expected/observed ratio was 1.01 (95% CI, 0.95 to 1.07). Age-adjusted C-statistics were 0.58 (95% CI, 0.56 to 0.59) overall and 0.63 (95% CI, 0.58 to 0.68) among women younger than 40 years. These measures were almost identical in the model based on estrogen receptor–specific relative risks and attributable risks. CONCLUSION Discriminatory accuracy of the new model was similar to that of the most frequently used questionnaire-based breast cancer risk prediction models in White women, suggesting that effective risk stratification for Black women is now possible. This model may be especially valuable for risk stratification of young Black women, who are below the ages at which breast cancer screening is typically begun.
A crown-group cnidarian from the Ediacaran of Charnwood Forest, UK.
Creators: name: Dunn, FS
name: Kenchington, CG
name: Parry, LA
name: Clark, JW
name: Kendall, RS
name: Wilby, PR
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/181/414
/631/181/757
article

description: Cnidarians are a disparate and ancient phylum, encompassing corals and jellyfish, and occupy both the pelagic and benthic realms. They have a rich fossil record from the Phanerozoic eon lending insight into the early history of the group but, although cnidarians diverged from other animals in the Precambrian period, their record from the Ediacaran period (635-542 million years ago) is controversial. Here, we describe a new fossil cnidarian-Auroralumina attenboroughii gen. et sp. nov.-from the Ediacaran of Charnwood Forest (557-562 million years ago) that shows two bifurcating polyps enclosed in a rigid, polyhedral, organic skeleton with evidence of simple, densely packed tentacles. Auroralumina displays a suite of characters allying it to early medusozoans but shows others more typical of Anthozoa. Phylogenetic analyses recover Auroralumina as a stem-group medusozoan and, therefore, the oldest crown-group cnidarian. Auroralumina demonstrates both the establishment of the crown group of an animal phylum and the fixation of its body plan tens of millions of years before the Cambrian diversification of animal life.
Long-term and serious harms of medical cannabis and cannabinoids for chronic pain: a systematic review of non-randomised studies.
Creators: name: Zeraatkar, Dena
name: Cooper, Matthew Adam
name: Agarwal, Arnav
name: Vernooij, Robin WM
name: Leung, Gareth
name: Loniewski, Kevin
name: Dookie, Jared E
name: Ahmed, Muhammad Muneeb
name: Hong, Brian Y
name: Hong, Chris
name: Hong, Patrick
name: Couban, Rachel
name: Agoritsas, Thomas
name: Busse, Jason W
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Medical management
1506
1710
Pain management
PAIN MANAGEMENT
PRIMARY CARE

description: OBJECTIVE: To establish the prevalence of long-term and serious harms of medical cannabis for chronic pain. DESIGN: Systematic review and meta-analysis. DATA SOURCES: MEDLINE, EMBASE, PsycINFO and CENTRAL from inception to 1 April 2020. STUDY SELECTION: Non-randomised studies reporting on harms of medical cannabis or cannabinoids in adults or children living with chronic pain with ≥4 weeks of follow-up. DATA EXTRACTION AND SYNTHESIS: A parallel guideline panel provided input on the design and interpretation of the systematic review, including selection of adverse events for consideration. Two reviewers, working independently and in duplicate, screened the search results, extracted data and assessed risk of bias. We used random-effects models for all meta-analyses and the Grades of Recommendations, Assessment, Development and Evaluation approach to evaluate the certainty of evidence. RESULTS: We identified 39 eligible studies that enrolled 12 143 adult patients with chronic pain. Very low certainty evidence suggests that adverse events are common (prevalence: 26.0%; 95% CI 13.2% to 41.2%) among users of medical cannabis for chronic pain, particularly any psychiatric adverse events (prevalence: 13.5%; 95% CI 2.6% to 30.6%). Very low certainty evidence, however, indicates serious adverse events, adverse events leading to discontinuation, cognitive adverse events, accidents and injuries, and dependence and withdrawal syndrome are less common and each typically occur in fewer than 1 in 20 patients. We compared studies with <24 weeks and ≥24 weeks of cannabis use and found more adverse events reported among studies with longer follow-up (test for interaction p<0.01). Palmitoylethanolamide was usually associated with few to no adverse events. We found insufficient evidence addressing the harms of medical cannabis compared with other pain management options, such as opioids. CONCLUSIONS: There is very low certainty evidence that adverse events are common among people living with chronic pain who use medical cannabis or cannabinoids, but that few patients experience serious adverse events.
Steromphala brocchii
Creators: name: Harzhauser, Mathias
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Trochida
Trochidae
Steromphala
Steromphala brocchii

description: Steromphala brocchii (Mayer in Cocconi, 1873) †
Pliocene (Zanclean): Mediterranean Sea (Italy).
Pleistocene: Mediterranean Sea (Italy).
(Chirli 2004)
description: Published as part of Harzhauser, Mathias, 2021, The Cainozoic to present-day record of Circum-Mediterranean, NE Atlantic and North Sea Cantharidinae and Trochinae (Trochoidea, Gastropoda) - a synopsis, pp. 1-81 in Zootaxa 4902 (1) on page 58, DOI: 10.11646/zootaxa.4902.1.1, http://zenodo.org/record/4419088
RE: Advanced Breast Cancer Definitions by Staging System Examined in the Breast Cancer Surveillance Consortium
Creators: name: Schnall, M.D
name: Pisano, E.D
name: Troester, M.A
name: Gatsonis, C
name: Sparano, J
name: Yaffe, M
name: Cole, E
Publisher: name: Oxford University Press
Year: 2021

description: As investigators for ECOG-ACRIN’s Tomosynthesis Mammographic Imaging Screening Trial (TMIST) trial, we are writing to draw attention to conceptual issues in the outcome definitions and study population in Kerlikowske et al. (1), which limit inferences with respect to the TMIST trial.
Robotic oncologic colorectal surgery with a new robotic platform (CMR Versius): hope or hype? A preliminary experience from a full-robotic case-series.
Creators: name: Huscher, Cristiano
name: Marchegiani, Francesco
name: Cobellis, Francesco
name: Tejedor, Patricia
name: Pastor, Carlos
name: Lazzarin, Gianni
name: Wheeler, James
name: Di Saverio, Salomone
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Multimedia Article
Colorectal cancer
Robotic surgery
Minimally invasive surgery
Robotics

description: BACKGROUND: The present case-series describes the first full-robotic colorectal resections performed with the new CMR Versius platform (Cambridge Medical Robotics Surgical, 1 Evolution Business Park, Cambridge, United Kingdom) by an experienced robotic surgeon. METHODS: In a period between July 2020 and December 2020, patients aged 18 years or older, who were diagnosed with colorectal cancer and were fit for minimally invasive surgery, underwent robotic colorectal resection with CMR Versius robotic platform at "Casa di Cura Cobellis" in Vallo della Lucania,Salerno, Italy. Three right colectomies, 2 sigmoid colectomies and 1 anterior rectal resection were performed. All the procedures were planned as fully robotic. Surgical data were retrospectively reviewed from a prospectively collected database. RESULTS: Four patients were male and 2 patients were female with a median (range) age of 66 (47-72) years. One covering ileostomy was created. Full robotic splenic flexure mobilization was performed. No additional laparoscopic gestures or procedures were performed in this series except for clipping and stapling which were performed by the assistant surgeon due to the absence of robotic dedicated instruments. Two ileocolic anastomoses, planned as robotic-sewn, were performed extracorporeally. One Clavien-Dindo II complication occurred due to a postoperative blood transfusion. Median total operative time was 160 (145-294) min for right colectomies, 246 (191-300) min for sigmoid colectomies and 250 min for the anterior rectal resection. CONCLUSIONS: The present series confirms the feasibility of full-robotic colorectal resections while highlighting the strengths and the limitations of the CMR Versius platform in colorectal surgery. New devices will need more clinical development to be comparable to the current standard.
Prediction of critical micelle concentration for per- and polyfluoroalkyl substances
Creators: name: Creton, B.
name: Barraud, E.
name: Nieto-Draghi, C.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer

description: In this study, we focus on the development of Quantitative Structure-Property Relationship (QSPR) models to predict the critical micelle concentration (CMC) for per- and polyfluoroalkyl substances (PFASs). Experimental CMC values for both fluorinated and non-fluorinated compounds were meticulously compiled from existing literature sources. Our approach involved constructing two distinct types of models based on Support Vector Machine (SVM) algorithms applied to the dataset. Type (I) models were trained exclusively on CMC values for fluorinated compounds, while Type (II) models were developed utilizing the entire dataset, incorporating both fluorinated and non-fluorinated compounds. Comparative analyses were conducted against reference data, as well as between the two model types. Encouragingly, both types of models exhibited robust predictive capabilities and demonstrated high reliability. Subsequently, the model having the broadest applicability domain was selected to complement the existing experimental data, thereby enhancing our understanding of PFAS behaviour.
ИСПОЛЬЗОВАНИЕ ХЛОРЕЛЛЫ В ПЕРЕПЕЛЕВОДСТВЕ
Creators: name: Хужаева Н. Ходжаева Н.
Publisher: name: Zenodo
Year: 2024

description: Изучено влияние суспезии хлореллы на рост и развитиеперепелов. Предложено включить в рацион питания перепелов в качествебиодобавки к основному корму суспензию хлореллы, что позволит улучшитьзоотехнические и экономические показатели, оказывает положительноевлияние на увеличении живого веса, яйценосность и их жизнеспособностьперепелов
DeCompress: Tissue compartment deconvolution of targeted mRNA expression panels using compressed sensing
Creators: name: Troester, M.A
name: Love, M.I
name: Hamilton, A.M
name: Bhattacharya, A
Publisher: name: Oxford University Press
Year: 2021

description: Targeted mRNA expression panels, measuring up to 800 genes, are used in academic and clinical settings due to low cost and high sensitivity for archived samples. Most samples assayed on targeted panels originate from bulk tissue comprised of many cell types, and cell-type heterogeneity confounds biological signals. Reference-free methods are used when cell-type-specific expression references are unavailable, but limited feature spaces render implementation challenging in targeted panels. Here, we present DeCompress, a semi-reference-free deconvolution method for targeted panels. DeCompress leverages a reference RNA-seq or microarray dataset from similar tissue to expand the feature space of targeted panels using compressed sensing. Ensemble reference-free deconvolution is performed on this artificially expanded dataset to estimate cell-type proportions and gene signatures. In simulated mixtures, four public cell line mixtures, and a targeted panel (1199 samples; 406 genes) from the Carolina Breast Cancer Study, DeCompress recapitulates cell-type proportions with less error than reference-free methods and finds biologically relevant compartments. We integrate compartment estimates into cis-eQTL mapping in breast cancer, identifying a tumor-specific cis-eQTL for CCR3 (C-C Motif Chemokine Receptor 3) at a risk locus. DeCompress improves upon reference-free methods without requiring expression profiles from pure cell populations, with applications in genomic analyses and clinical settings.
The Great Ant Scooter Group
Creators: name: Moy, Kelly
Publisher: name: Zenodo
Year: 2022
Subjects: Antichrist insects ants "the end of the world" equations "Georgia Tech" "fun race"

description: Ben and Winston discover ants that can talk and they know a lot about human civilization. Ben's mom is an entomologist and becomes instantly famous after making videos of the ans and publishing in ENTOMOLOGY TODAY. The Prophet Ant said there is going to be an AirChipShip race to celebrate interspecies communication. The AirChipShip race is set on the campus of Georgia Tech. There is a look into various labs on the campus. Three papers authored by John Jennings are featured and cited at the end. There is a chase scene and the fate of the Antichrist comes on the radio. Included are four telling illustrations and there is a religious element as all look forward to the end.
In silico insights into design of novel VEGFR-2 inhibitors: SMILES-based QSAR modelling, and docking studies on substituted benzo-fused heteronuclear derivatives
Creators: name: Gupta, S.
name: Kashyap, M.
name: Bansal, Y.
name: Bansal, G.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: Virology

description: Eight QSAR models (M1–M8) were developed from a dataset of 118 benzo-fused heteronuclear derivatives targeting VEGFR-2 by Monte Carlo optimization method of CORALSEA 2023 software. Models were generated with hybrid optimal descriptors using both SMILES and Graphs with zero- and first-order Morgan extended connectivity index from a training set of 103 derivatives. All statistical parameters for model validation were within the prescribed limits, establishing the models to be robust and of excellent quality. Among all models, split-2 of M5 was the best-fit as reflected by  rvalidation2,  Qvalidation2 and MAE. Mechanistic interpretation of this model assisted the identification of structural descriptors as promoters and hinderers for VEGFR-2 inhibition. These descriptors were utilized to design novel VEGFR-2 inhibitors (YS01-YS07) by bringing modifications in compound MS90 in the dataset. Docking of all designed compounds, MS90 and sorafenib with VEGFR-2 binding site revealed favourable binding interactions. Docking score of YS07 was higher than that of MS90 and sorafenib. Molecular dynamics simulation study revealed sustained interactions of YS07 with key amino acids of VEGFR-2 at a run time of 100 ns. This study concludes the development of a best fit QSAR model which can assist the design of new anticancer agents targeting VEGFR-2.
Adherence to Endocrine Therapy and Racial Outcome Disparities in Breast Cancer
Creators: name: Wheeler, S.B
name: Reeder-Hayes, K.E
name: Troester, M.A
Publisher: name: John Wiley and Sons Inc
Year: 2021

description: The disparity in outcomes of breast cancer for Black compared with White women in the U.S. is well known and persistent over time, with the largest disparities appearing among women with hormone receptor-positive (HR+) cancers. The racial gap in breast cancer survival first emerged in the 1980s, a time of significantmen treatment advances in early-stage breast cancer, including the introduction of adjuvant endocrine therapy. Since that time, the gap has continued to widen despite steady advances in treatment and survival of breast cancer overall. Although advanced stage at presentation and unfavorable biology undoubtedly contribute to racial differences in survival of HR+ breast, treatment disparities are increasingly acknowledged to play a key role as well. The recent recognition of racial differences in endocrine therapy use may be a key explanatory factor in the persistent racial gap in mortality of HR+ disease, and may be a key focus of intervention to improve breast cancer outcomes for Black women. Implications for Practice: Black women with hormone receptor–positive breast cancer experience the greatest racial disparity in survival among all breast cancer subtypes. This survival gap appears consistently across studies and is not entirely explained by differences in presenting stage, tumor biology as assessed by genomic risk scores, or receipt of chemotherapy. Recent research highlights lower adherence to endocrine therapy (ET) for Black women. Health systems and individual providers should focus on improving communication about the importance of ET use, sharing decisions around ET, providing appropriate support for side effects and other ET-related concerns, and equitably delivering survivorship care, including ET adherence assessment.
Steromphala cineraria
Creators: name: Harzhauser, Mathias
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Trochida
Trochidae
Steromphala
Steromphala cineraria

description: * Steromphala cineraria (Linnaeus, 1758)
Figs 7V 1 –V 2
Pleistocene (late Pleistocene): North Sea (The Netherlands).
Present-day: North Sea, NE Atlantic Ocean (Azores, Canary Islands, Morocco).
(Pouwer & Wesselingh 2012)
description: Published as part of Harzhauser, Mathias, 2021, The Cainozoic to present-day record of Circum-Mediterranean, NE Atlantic and North Sea Cantharidinae and Trochinae (Trochoidea, Gastropoda) - a synopsis, pp. 1-81 in Zootaxa 4902 (1) on page 58, DOI: 10.11646/zootaxa.4902.1.1, http://zenodo.org/record/4419088
Radon and cancer mortality among underground uranium miners in the Příbram region of the Czech Republic
Creators: name: Shore, D
name: Sandler, D.P
name: Richardson, D.B
name: Kelly-Reif, K
name: Nylander-French, L
name: Troester, M.A
name: Schubauer-Berigan, M.K
Publisher: name: Wiley-Liss Inc.
Year: 2020

description: Background: This study aims to estimate the association between radon and site-specific cancer mortality among a large contemporary cohort of male uranium miners. Methods: Annual occupational radon exposure was estimated based on a worker's duration of underground mining in a year and estimates of potential alpha energy of radon progeny in their location of work. Cancer mortality over the period 1977-1992 was ascertained for a cohort of 16 434 male underground uranium miners employed in the Czech Republic between 1946 and 1992. Poisson regression was used to estimate relationships between cumulative radiation exposure (in working level months [WLM]) and site-specific cancer mortality. Results: Radon is positively associated with lung cancer mortality (excess relative rate [ERR] per 100 WLM = 0.2; 95% confidence interval [CI]: 0.10, 0.37). The best fit of the dose-response relationship between radon and lung cancer mortality was linear and estimates of radon-lung cancer associations varied by windows of time-since-exposure. Positive associations between radon and several types of cancer other than lung cancer were identified, notably chronic lymphocytic leukemia (CLL) (ERR/100 WLM = 0.24; 95% CI: [not determined [ND], 5.10]) and extrathoracic cancer (ERR/100 WLM = 0.12; 95% CI: [ND, 0.69]). We observed no associations between radon and stomach cancer, nor between radon and several hematopoietic cancer subtypes. Conclusions: This study confirms the established radon-lung cancer association and suggests that radon may also be associated with other types of cancer mortality. Further investigations of extrathoracic and CLL cancer, with the aim of obtaining more precise estimates, are warranted to understand associations between radon and cancers other than lung.
Risk factors for estrogen receptor positive ductal carcinoma in situ of the breast in African American women
Creators: name: Bandera, E.V
name: Troester, M.A
name: Bethea, T.N
name: Palmer, J.R
name: Rosenberg, L
name: Khoury, T
name: Bertrand, K.A
name: Ambrosone, C.B
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Background: Compared to U.S. white women, African American women are more likely to die from ductal carcinoma in situ (DCIS). Elucidation of risk factors for DCIS in African American women may provide opportunities for risk reduction. Methods: We used data from three epidemiologic studies in the African American Breast Cancer Epidemiology and Risk Consortium to study risk factors for estrogen receptor (ER) positive DCIS (488 cases; 13,830 controls). Results were compared to associations observed for ER+ invasive breast cancer (n = 2,099). Results: First degree family history of breast cancer was associated with increased risk of ER+ DCIS [odds ratio (OR): 1.69, 95% confidence interval (CI): 1.31, 2.17]. Oral contraceptive use within the past 10 years (vs. never) was also associated with increased risk (OR: 1.43, 95%CI: 1.03, 1.97), as was late age at first birth (≥25 years vs. <20 years) (OR: 1.26, 95%CI: 0.96, 1.67). Risk was reduced in women with older age at menarche (≥15 years vs. <11 years) (OR: 0.62, 95%CI: 0.42, 0.93) and higher body mass index (BMI) in early adulthood (≥25 vs. <20 kg/m2 at age 18 or 21) (OR: 0.75, 95%CI: 0.55, 1.01). There was a positive association of recent BMI with risk in postmenopausal women only. In general, associations of risk factors for ER+ DCIS were similar in magnitude and direction to those for invasive ER+ breast cancer. Conclusions: Our findings suggest that most risk factors for invasive ER+ breast cancer are also associated with increased risk of ER+ DCIS among African American women.
Steromphala cineroides
Creators: name: Harzhauser, Mathias
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Trochida
Trochidae
Steromphala
Steromphala cineroides

description: Steromphala cineroides (Wood, 1842) †
Pliocene (Zanclean to Piacenzian): North Sea (Belgium, British Isles).
(Marquet & Landau 2006)
description: Published as part of Harzhauser, Mathias, 2021, The Cainozoic to present-day record of Circum-Mediterranean, NE Atlantic and North Sea Cantharidinae and Trochinae (Trochoidea, Gastropoda) - a synopsis, pp. 1-81 in Zootaxa 4902 (1) on page 58, DOI: 10.11646/zootaxa.4902.1.1, http://zenodo.org/record/4419088
Additional file 1 of Implementing a new physiotherapist-led primary care model for low back pain: a qualitative study of patient and primary care team perspectives
Creators: name: Vader, Kyle
name: Donnelly, Catherine
name: French, Simon D.
name: Grady, Colleen
name: Hill, Jonathan C.
name: Tripp, Dean A.
name: Williams, Ashley
name: Miller, Jordan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. Additional supporting quotations
Steromphala dertosulcata
Creators: name: Harzhauser, Mathias
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Trochida
Trochidae
Steromphala
Steromphala dertosulcata

description: Steromphala dertosulcata (Sacco, 1896) †
Late Miocene (Tortonian): Mediterranean Sea (Italy, Po Valley).
(Ferrero-Mortara et al. 1984)
description: Published as part of Harzhauser, Mathias, 2021, The Cainozoic to present-day record of Circum-Mediterranean, NE Atlantic and North Sea Cantharidinae and Trochinae (Trochoidea, Gastropoda) - a synopsis, pp. 1-81 in Zootaxa 4902 (1) on page 58, DOI: 10.11646/zootaxa.4902.1.1, http://zenodo.org/record/4419088
Additional file 1 of Adverse childhood experiences are associated with a higher risk for increased depressive symptoms during Covid-19 pandemic – a cross-sectional study in Germany
Creators: name: Clemens, Vera
name: Köhler-Dauner, Franziska
name: Keller, Ferdinand
name: Ziegenhain, Ute
name: Fegert, Jörg M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1.
Steromphala distefanoi
Creators: name: Harzhauser, Mathias
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Trochida
Trochidae
Steromphala
Steromphala distefanoi

description: Steromphala distefanoi (Crema, 1903) †
Pliocene (Zanclean): Mediterranean Sea (Italy).
Pleistocene: Mediterranean Sea (Italy).
(Spadini 1987b; Chirli 2004)
description: Published as part of Harzhauser, Mathias, 2021, The Cainozoic to present-day record of Circum-Mediterranean, NE Atlantic and North Sea Cantharidinae and Trochinae (Trochoidea, Gastropoda) - a synopsis, pp. 1-81 in Zootaxa 4902 (1) on page 58, DOI: 10.11646/zootaxa.4902.1.1, http://zenodo.org/record/4419088
Inter-Individual Variation in Response to Estrogen in Human Breast Explants
Creators: name: Bigelow, C
name: Sharma, A
name: Black, A.L
name: Makari-Judson, G
name: Troester, M.A
name: Ser-Dolansky, J
name: Browne, E.P
name: Arcaro, K.F
name: Roberts, A.L
name: Li, Z
name: Dunphy, K.A
name: Crisi, G.M
name: Schneider, S.S
name: Suresh, S
name: Jerry, D.J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Exposure to estrogen is strongly associated with increased breast cancer risk. While all women are exposed to estrogen, only 12% are expected to develop breast cancer during their lifetime. These women may be more sensitive to estrogen, as rodent models have demonstrated variability in estrogen sensitivity. Our objective was to determine individual variation in expression of estrogen receptor (ER) and estrogen-induced responses in the normal human breast. Human breast tissue from female donors undergoing reduction mammoplasty surgery were collected for microarray analysis of ER expression. To examine estrogen-induced responses, breast tissue from 23 female donors were cultured ex- vivo in basal or 10 nM 17β-estradiol (E2) media for 4 days. Expression of ER genes (ESR1 and ESR2) increased significantly with age. E2 induced consistent increases in global gene transcription, but expression of target genes AREG, PGR, and TGFβ2 increased significantly only in explants from nulliparous women. E2-treatment did not induce consistent changes in proliferation or radiation induced apoptosis. Responses to estrogen are highly variable among women and not associated with levels of ER expression, suggesting differences in intracellular signaling among individuals. The differences in sensitivity to E2-stimulated responses may contribute to variation in risk of breast cancer.
Additional file 1 of Clonal evolution in primary breast cancers under sequential epirubicin and docetaxel monotherapy
Creators: name: Venizelos, Andreas
name: Engebrethsen, Christina
name: Deng, Wei
name: Geisler, Jürgen
name: Geisler, Stephanie
name: Iversen, Gjertrud T.
name: Aas, Turid
name: Aase, Hildegunn S.
name: Seyedzadeh, Manouchehr
name: Steinskog, Eli Sihn
name: Myklebost, Ola
name: Nakken, Sigve
name: Vodak, Daniel
name: Hovig, Eivind
name: Meza-Zepeda, Leonardo A.
name: Lønning, Per E.
name: Knappskog, Stian
name: Eikesdal, Hans P.
Publisher: name: figshare
Year: 2022
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 1. The Dose Dense Trial (Methods and Results) and Sequencing approaches.
Steromphala divaricata
Creators: name: Harzhauser, Mathias
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Trochida
Trochidae
Steromphala
Steromphala divaricata

description: Steromphala divaricata (Linnaeus, 1758)
Pleistocene (late Pleistocene): Mediterranean Sea.
Present-day: Mediterranean Sea, Black Sea, Sea of Azov.
(Anistratenko 2005; Affenzeller et al. 2017)
description: Published as part of Harzhauser, Mathias, 2021, The Cainozoic to present-day record of Circum-Mediterranean, NE Atlantic and North Sea Cantharidinae and Trochinae (Trochoidea, Gastropoda) - a synopsis, pp. 1-81 in Zootaxa 4902 (1) on page 58, DOI: 10.11646/zootaxa.4902.1.1, http://zenodo.org/record/4419088
Additional file 2 of Clonal evolution in primary breast cancers under sequential epirubicin and docetaxel monotherapy
Creators: name: Venizelos, Andreas
name: Engebrethsen, Christina
name: Deng, Wei
name: Geisler, Jürgen
name: Geisler, Stephanie
name: Iversen, Gjertrud T.
name: Aas, Turid
name: Aase, Hildegunn S.
name: Seyedzadeh, Manouchehr
name: Steinskog, Eli Sihn
name: Myklebost, Ola
name: Nakken, Sigve
name: Vodak, Daniel
name: Hovig, Eivind
name: Meza-Zepeda, Leonardo A.
name: Lønning, Per E.
name: Knappskog, Stian
name: Eikesdal, Hans P.
Publisher: name: figshare
Year: 2022
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 2. Study Protocol.