cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dynamical systems with fast switching and slow diffusion: Hyperbolic equilibria and stable limit cycles
Creators: name: Du, Nguyen H.
name: Hening, Alexandru
name: Nguyen, Dang H.
name: Yin, George
Publisher: name: arXiv
Year: 2019
Subjects: subject: Probability (math.PR)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 34C05, 60H10, 92D25

description: We study the long-term qualitative behavior of randomly perturbed dynamical systems. More specifically, we look at limit cycles of stochastic differential equations (SDE) with Markovian switching, in which the process switches at random times among different systems of SDEs, when the switching is fast and the diffusion (white noise) term is small. The system is modeled by $$ dX^{ε,δ}(t)=f(X^{ε,δ}(t), α^ε(t))dt+\sqrtδσ(X^{ε,δ}(t), α^ε(t))dW(t) , \ X^ε(0)=x, $$ where $α^ε(t)$ is a finite state space Markov chain with irreducible generator $Q=(q_{ij})$. The relative changing rates of the switching and the diffusion are highlighted by the two small parameters $ε$ and $δ$. We associate to the system the averaged ODE \[ d\bar X(t)=\bar f(\bar X(t))dt, \ X(0)=x, \] where $\bar f(\cdot)=\sum_{i=1}^{m_0}f(\cdot, i)ν_i$ and $(ν_1,\dots,ν_{m_0})$ is the unique invariant probability measure of the Markov chain with generator $Q$. Suppose that for each pair $(ε,δ)$ of parameters, the process has an invariant probability measure $μ^{ε,δ}$, and that the averaged ODE has a limit cycle in which there is an averaged occupation measure $μ^0$ for the averaged equation. We are able to prove that if $\bar f$ has finitely many unstable or hyperbolic fixed points, then $μ^{ε,δ}$ converges weakly to $μ^0$ as $ε\to 0$ and $δ\to 0$. Our results generalize to the setting of state-dependent switching \[ \mathbb{P}\{α^ε(t+Δ)=j~|~α^ε=i, X^{ε,δ}(s),α^ε(s), s\leq t\}=q_{ij}(X^{ε,δ}(t))Δ+o(Δ),~~ i\neq j \] as long as the generator $Q(\cdot)=(q_{ij}(\cdot))$ is bounded, Lipschitz, and irreducible for all $x\in\mathbb{R}^d$. We conclude our analysis by studying a predator-prey model.
description: 41 pages, 5 figures
title: Cochlea Implantation im Kindesalter und Bilingualität
Creators: name: Arweiler-Harbeck, Diana
name: Dockter, Sonja
name: Hasskamp, Pia
name: Bagus, Heike
name: Bebout, Johanna
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Bedingt durch eine zunehmende Zahl von Familien mit Migrationshintergrund unterschiedlicher Kulturen und Nationalitäten steigt auch die Zahl von Kindern mit einer an Taubheit grenzenden Innenohrschwerhörigkeit, die mit Cochlea Implantaten versorgt werden und in einem bilingualen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
นอร์มของเมทริกซ์อาร์-เซอร์คูแลนท์สมมาตร และเมทริกซ์เซอร์คูแลนท์เชิงเรขาคณิตสมมาตรกับจำนวนไฮเพอร์ฮาร์มอนิกฟีโบนักชี
Creators: name: อัจฉรา ปาจีนบูรวรรณ์
Publisher: name: กองบริหารการวิจัย
Year: 2565
Subjects: เมทริกซ์อาร์-เซอร์คูแลนท์สมมาตร
เมทริกซ์เซอร์คูแลนท์เชิงเรขาคณิตสมมาตร
จำนวนไฮเพอร์ฮาร์มอนิกฟีโบนักชี
เมทริกซ์นอร์ม

description: วารสารวิทยาศาสตร์และเทคโนโลยี, 30, 2, 110-125
Preparation and characterisation of laterally monofluorinated mesogenic benzimidazole-based compounds
Creators: name: Duan, Longyan
name: Shi, Dingqian
name: Chen, Pei
name: Zhang, Lina
name: Ren, Liyuan
name: Chen, Xinbing
name: An, Zhongwei
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Series of laterally monofluorinated compounds, 2-(4ʹ-alkoxy-3-fluorobiphenyl-4-yl)-1H-benzimidazole derivatives (nPPF(3)Mx) bearing different substituents (H, CH3, NO2, coded as nPPF(3)MH, nPPF(3)MM and nPPF(3)MN, respectively) at 5-position, were prepared and their structures were characterised. According to the results from differential scanning calorimetry and polarising optical microscopy, the present compounds nPPF(3)Mx exhibit enantiotropic smectic mesophases, for which the mesophase ranges are 13–67 and 47–111°C on heating and cooling for nPPF(3)MH, 84–112 and 126–154°C for nPPF(3)MM, and 23–102 and 49–117°C for nPPF(3)MN, respectively. Compared to non-fluorinated analogues, monofluorinated nPPF(3)Mx have low melting/clearing points and display enhanced mesophase range both in heating and cooling, which are attributed to the disruption of the side-to-side intermolecular packing caused by the ortho lateral fluoro substituents and the increased dipole–dipole interaction between the polar fluoro-substituted molecules, respectively. It is noted that nPPF(3)MM and nPPF(3)MN show a much wider mesophase range than nPPF(3)MH, which suggest that the substituent at benzimidazole moiety can improve the mesophase stability.
Interdisciplinarities of Origin: Modernism, Psychoanalysis and Imperialism
Creators: name: Valentine, Kylie
Publisher: name: Monash University
Year: 2017
Subjects: subject: 200503 British and Irish Literature
subject: FOS: Languages and literature
subject: 209999 Language, Communication and Culture not elsewhere classified

description: "Imperialism has been identified as a central and significant element within the field of British modernism. A number of writers foreground imperialism as a prerequisite of modernist production. Edward Said, for example, writes that all metropolitan politics and art movements were constituted, during the modernist movement, by their location in the imperialist economy: 'Eurocentrism penetrated to the core of the workers’ movement, the women’s movement, the avant-garde arts movement, leaving no one of significance untouched.' (1) Fredric Jameson’s analysis of E. M. Forster and Virginia Woolf is animated by an argument that 'the structure of imperialism also makes its mark on the inner forms and structures of that new mutation in literary and artistic language to which the term modernism is loosely applied.' (2) Other arguments engage with the ways modernism can be understood as a response to the conditions of imperialism. Kathy Phillips’s Virginia Woolf Against Empire argues, as the title suggests, that Woolf both specifically castigated imperialism and made complaints against '"Empire" as an inclusive term, encompassing economics, gender relations, and war making, as these forces operate at home and abroad.' (3) Bernard Smith’s analysis of modernism in the visual arts argues that imperialism had a direct effect on the rejection of naturalism, 'manifest in the desire to create a universal art with a European look, a formal art that might be globally negotiable among all the heterogeneous cultures of the world.' (4) Gayatri Spivak has famously argued that: 'It should not be possible to read nineteenth-century British literature without remembering that imperialism, understood as Britain’s social mission, was a crucial part of the cultural representation of England to the English.' (5) While this understanding of imperialism was certainly challenged at the hands of modernism, it is also true that imperialism remained the overarching condition of modernist possibility."
title: Cochlea Implantat-Revisionen – häufige Ursachen
Creators: name: Hussain, Timon
name: Hans, Stefan
name: Holtmann, Laura
name: Höing, Benedikt
name: Lang, Stephan
name: Arweiler-Harbeck, Diana
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: In den vergangenen 10 Jahren wurden in Deutschland über 30.000 Patienten mit einem Cochlea Implantat (CI) versorgt – mit steigender Tendenz. Trotz geringer intra- und post-operativer Komplikationsraten und seltener Gerätdefekte erfolgen regelmäßig CI-Explantationen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
title: Computerbasierte Kognitionstestung im Alter
Creators: name: Völter, Christiane
name: Götze, Lisa
name: Falkenstein, Michael
name: Dazert, Stefan
name: Thomas, Jan Peter
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Im Hinblick auf die Wechselwirkung zwischen Hören und Kognition und angesichts der demographischen Entwicklung gewinnt die Frage nach den neurokognitiven Fähigkeiten der älteren Schwerhörigen an Bedeutung. Bislang werden diese meist mit Paper and Pencil basierten Testverfahren[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
title: Structural Architecture and Permeability Patterns of Crystalline Reservoir Rocks in the Northern Upper Rhine Graben: Insights from Surface Analogues of the Odenwald
Creators: name: Bossennec, Claire
name: Seib, Lukas
name: Frey, Matthis
name: Vaart, Jeroen van der
name: Sass, Ingo
Publisher: name: MDPI
Year: 2022

description: Fracture network is a crucial element to address in any model of the thermo-hydro-mechanical behaviour of a reservoir rock. This study aims to provide quantified datasets and a further understanding of the critical parameters of the fracture network pattern in crystalline rocks. In the Northern Upper Rhine Graben, such rock units are targeted for multiple energy applications, from deep geothermal heat extraction to heat storage. Eleven outcrops were investigated with a combined LiDAR and 2D profiles analysis to extract faults and fracture network geometrical parameters, including length distribution, orientation, connectivity, and topology. These properties are used to decipher the structural architecture and estimate the flow properties of crystalline units. Fracture networks show a multi-scale power-law behaviour for length distribution. Fracture topology and orientation are mainly driven by both fault networks and lithology. Fracture apertures and permeability tensors were then calculated for two application case studies, including the stress field effect on aperture. Obtained permeabilities are in the range of those observed in the sub-surface in currently exploited reservoirs. The dataset provided in this study is thus suitable to be implemented in the modelling during the exploration stage of industrial applications involving fractured crystalline reservoirs.
title: 03_0033
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
title: Computerbasiertes Hörtraining im Rahmen der CI-Rehabilitation
Creators: name: Völter, Christiane
name: Schirmer, Christiane
name: Stöckmann, Carolin
name: Bilda, Kerstin
name: Dazert, Stefan
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Bedingt durch die demographische Entwicklung nimmt die Zahl der Cochleaimplantationen vor allem im Erwachsenenalter zu. Die aufwändige postoperativ erforderliche Hör- und Sprachtherapie erfolgt bislang meist Face-to-Face in spezialisierten Zentren. Mit Blick auf die personellen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Accuracy of the dose-shift approximation in estimating the delivered dose in SBRT of lung tumors considering setup errors and breathing motions
Creators: name: Karlsson, Kristin
name: Lax, Ingmar
name: Lindbäck, Elias
name: Poludniowski, Gavin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Computational Biology

description: Introduction: Geometrical uncertainties can result in a delivered dose to the tumor different from that estimated in the static treatment plan. The purpose of this project was to investigate the accuracy of the dose calculated to the clinical target volume (CTV) with the dose-shift approximation, in stereotactic body radiation therapy (SBRT) of lung tumors considering setup errors and breathing motion. The dose-shift method was compared with a beam-shift method with dose recalculation. Material and methods: Included were 10 patients (10 tumors) selected to represent a variety of SBRT-treated lung tumors in terms of tumor location, CTV volume, and tumor density. An in-house developed toolkit within a treatment planning system allowed the shift of either the dose matrix or a shift of the beam isocenter with dose recalculation, to simulate setup errors and breathing motion. Setup shifts of different magnitudes (up to 10 mm) and directions as well as breathing with different peak-to-peak amplitudes (up to 10:5:5 mm) were modeled. The resulting dose–volume histograms (DVHs) were recorded and dose statistics were extracted. Results: Generally, both the dose-shift and beam-shift methods resulted in calculated doses lower than the static planned dose, although the minimum (D98%) dose exceeded the prescribed dose in all cases, for setup shifts up to 5 mm. The dose-shift method also generally underestimated the dose compared with the beam-shift method. For clinically realistic systematic displacements of less than 5 mm, the results demonstrated that in the minimum dose region within the CTV, the dose-shift method was accurate to 2% (root-mean-square error). Breathing motion only marginally degraded the dose distributions. Conclusions: Averaged over the patients and shift directions, the dose-shift approximation was determined to be accurate to approximately 2% (RMS) within the CTV, for clinically relevant geometrical uncertainties for SBRT of lung tumors.
title: Das Mukoepidermoid-Karzinom der Glandula parotis im Kindesalter
Creators: name: Kouki, Phillip
name: Luckhaupt, Horst
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Lediglich 10% aller kindlichen Malignome sind Kopf-Hals-Tumoren und 50% aller malignen Kopf-Hals-Tumoren bei Kindern sind Mukoepidermoid-Karzinome. Das Inzidenz-Maximum liegt in der 2. und 8. Lebensdekade. Frauen sind doppelt so häufig betroffen wie Männer. Hauptmanifestationsorte[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
title: Der „therapieresistente“ benigne paroxysmale Lagerungsschwindel – strategisches Vorgehen und Lösungsansätze
Creators: name: Ilgner, Justus
name: Duong Dinh, Thien An
name: Westhofen, Martin
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Der benigne paroxysmale Lagerungsschwindel (BPLS) ist dank anamnestischer und klinischer Charakteristika ein in der Regel klar zu diagnostizierendes Krankheitsbild, zu dem eine Reihe spezifischer bewährter Lagerungsmanöver als kurative Therapiemöglichkeiten zur Verfügung[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Earth Science Information Partners, Vision for the Future of Cyberinfrastructure
Creators: name: Law, Emily
name: White, Christine
name: Stace Beaulieu
name: Bishop, Wade
name: Bowring, James
name: Bristol, Sky
name: Jones, Dave
name: Hsu, Leslie
name: Scott, Soren
name: Duerr, Ruth
name: Robinson, Erin
name: Caron, Bruce
Publisher: name: ESIP
Year: 2017
Subjects: subject: 40699 Physical Geography and Environmental Geoscience not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 49999 Earth Sciences not elsewhere classified

description: ESIP is a community of data and information technology practitioners who collaborate across Earth science organizations. Our response comes from the perspective of maximizing technical and organizational cooperation among diverse entities. First, the challenge of overcoming technical, institutional, and cultural barriers for pursuing transformative, interdisciplinary Earth and Space science. Another challenge is building semantic understanding across different research communities seamlessly. Fully taking advantage of the analytical resources available through big earth science data is another challenge, and the last is better support for research code and information provenance to improve and expedite research reproducibility. Regarding specific cyberinfrastructure needs, the first is support for data driven knowledge development via collaborative analytics and visualization. Another recommendation is that NSF leverages existing infrastructures and opportunities for partnering instead of duplicating or creating competing resources. The last need is for project support and sustainability, to transition projects into a next funding phase as appropriate. Our response concludes with an additional consideration regarding education. All stakeholders benefit from education emphasizing aspects of data curation, management, and data and software stewardship. ESIP recommends a multidisciplinary approach to cyberinfrastructure training to support current, as well as future researchers.
title: Der dreidimensionale Rotationsstuhl zur Behandlung des benignen paroxysmalen Lagerungsschwindels
Creators: name: Renson, Ariane
name: Ilgner, Justus
name: Duong Dinh, Thien An
name: Westhofen, Martin
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Zur Behandlung des primären benignen paroxysmalen Lagerungsschwindels sind die bekannten Lagerungsmanöver nach Epley, Semont, Asprella, Gufoni usw. allgemein wegen ihrer standardisierten Durchführung und reproduzierbar guter Ergebnisse bewährt. In der Praxis treten Limitationen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Experimental observation of information flow in the anti-$\mathcal{PT}$-symmetric system
Creators: name: Wen, Jingwei
name: Qin, Guoqing
name: Zheng, Chao
name: Wei, Shijie
name: Kong, Xiangyu
name: Xin, Tao
name: Long, Guilu
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The recently theoretical and experimental researches related to $\mathcal{PT}$-symmetric system have attracted unprecedented attention because of various novel features and potentials in extending canonical quantum mechanics. However, as the counterpart of $\mathcal{PT}$-symmetry, there are only a few researches on anti-$\mathcal{PT}$-symmetry. Here, we propose an algorithm for simulating the universal anti-$\mathcal{PT}$-symmetric system with quantum circuit. Utilizing the protocols, an oscillation of information flow is observed for the first time in our Nuclear Magnetic Resonance quantum simulator. We will show that information will recover from the environment completely when the anti-$\mathcal{PT}$-symmetry is broken, whereas no information can be retrieved in the symmetry-unbroken phase. Our work opens the gate for practical quantum simulation and experimental investigation of universal anti-$\mathcal{PT}$-symmetric system in quantum computer.
Aish Slope Table
Creators: name: Monish Raza
name: C.S.Malvi
Publisher: name: figshare
Year: 2017
Subjects: subject: 30207 Transition Metal Chemistry
subject: FOS: Chemical sciences
subject: 30202 f-Block Chemistry
subject: 30799 Theoretical and Computational Chemistry not elsewhere classified

description: Aish Slope Table: Periodic Table Recreation Incorporating Electron Filling Pattern In An Orbital
 Advanced version of periodic table covering all the demerits of periodic table. This includes periodic table, electronic configuration information, orbitals information, electron filling pattern information and more of the characteristics including Aufbau principle in a single table.
This is the natural solution for the term The Periodic Table. Any objections are welcome to be negotiated.
title: Digitale Medien zur Förderung einer effizienten und interaktiven Lehre in der HNO
Creators: name: Spiekermann, Christoph
name: Stenner, Markus
name: Rudack, Claudia
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Der Nationale kompetenzbasierte Lernzielkatalog für Medizin (NKLM) sowie der Masterplan 2020 vom (Institut für Medizinische und Pharmazeutische Prüfungsfragen) IMPP fordern eine Fokussierung der Lehre auf psychomotorische Lernziele sowie das Erreichen höherer Kompetenzniveaus.[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Integrating proteomics and genomic data to illuminatethe effects of Lapatinibin HER2+ cells
Creators: name: Laderas, Ted
name: Sonmez, Kemal
Publisher: name: figshare
Year: 2017
Subjects: subject: 111201 Cancer Cell Biology
subject: FOS: Clinical medicine
subject: 60114 Systems Biology
subject: FOS: Biological sciences

description: Poster given for NLM Training conference on understanding lapatinib sensitivity in HER2+ cells
Supplementary_material.pdf from Design of rigid-foldable doubly curved origami tessellations based on trapezoidal crease patterns
Creators: name: Song, Keyao
name: Zhou, Xiang
name: Zang, Shixi
name: Wang, Hai
name: You, Zhong
Publisher: name: The Royal Society
Year: 2017

description: Supplementary material, sections A, B and C
Physical Activity of Patients with COPD from Regions with Different Climatic Variations
Creators: name: Furlanetto, Karina Couto
name: Demeyer, Heleen
name: Thais Sant'anna
name: Hernandes, Nidia Aparecida
name: Camillo, Carlos Augusto
name: Pons, Ignasi Serra
name: Gosselink, Rik
name: Troosters, Thierry
name: Pitta, Fabio
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Seasonal changes in physical activity in daily life (PADL) of patients with Chronic Obstructive Pulmonary Disease (COPD) living in regions of the world with contrasting (i.e., mild or marked) weather variations have not been yet investigated. We aimed to quantify PADL and compare its variability caused by seasonality in patients with COPD who live in world regions with different summer-winter climatic variations (i.e. Londrina, Brazil and Leuven, Belgium). In a longitudinal, prospective and observational study, patients with COPD from Brazil and Belgium wore the SenseWear Armband for 7 days in summer and 7 days in winter. Active time (≥2METs) was the primary outcome. PADL data were matched day-by-day with weather information. Regarding the two assessment moments, median (min;max) temperatures were 11 (−5.5;27.2)°C in Leuven and 21 (7;27)°C in Londrina. Patients in Brazil (n = 19, 69 ± 7 years, FEV1 47 ± 15%pred) and Belgium (n = 18, 69 ± 6 years, FEV1 50 ± 15%pred) decreased their active time in winter compared to summer (p < 0.05), and this reduction was more pronounced in Brazil (p = 0.01, between group). Mean, minimum and maximum temperature, daylight duration and relative humidity were significantly related to active time. Patients with COPD decrease their PADL in winter even in a region with milder climatic variation.
Quantifying the Changeable Self: The Role of Self-Tracking in Coming to Terms With and Managing Bipolar Disorder
Creators: name: Matthews, Mark
name: Murnane, Elizabeth
name: Snyder, Jaime
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: There has been a recent increase in the development of digital self-tracking tools for managing mental illness. Most of these tools originate from clinical practice and are, as a result, largely clinician oriented. As a consequence, little is known about the self-tracking practices and needs of individuals living with mental illness. This understanding is important to guide the design of future tools to enable people to play a greater role in managing their health. In this article, we present a qualitative study focusing on the self-tracking practices of 10 people with bipolar disorder. We seek to understand the role self-tracking has played as they have come to grips with their diagnosis and attempted to self-manage their health. A central motivation for these participants is to identify risky patterns that may be harbingers of mood episodes, as well as positive trends that support recovery. What emerges is a fragmented picture of self-tracking, with no clear delineation between clinician-initiated and self-initiated practices, as well as considerable challenges participants face in making observations of themselves when their sense of self and emotional state is in flux, uncertain, and unreliable. Informed by these observations, we discuss the merits of a new form of self-tracking that combines manual and automated methods, addresses both clinician and individual needs, helps engage people with bipolar disorder in treatment, and seeks to overcome the significant challenges they face in self-monitoring.
Intrafamilial variability in syndromic microphthalmia type 5 caused by a novel variation in OTX2
Creators: name: Puneeth H. Somashekar
name: Shukla, Anju
name: Katta M. Girisha
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 60506 Virology

description: Background: Anophthalmia/microphthalmia/coloboma (MAC) spectrum encompasses the most severe malformations of the eye. Together, they have an incidence of 2 in 10,000 births and can be unilateral or bilateral. These disorders are genetically heterogeneous.Materials and methods: We ascertained a large three-generation family with multiple members showing variable phenotypes of syndromic microphthalmia. Exome sequencing was performed for the proband and his affected maternal aunt. Targeted sequencing of OTX2 gene was performed for other family members.Result: Variable clinical presentation in the form of unilateral microphthalmia and bilateral microphthalmia as well as nonpenetrance were noted. Exome sequencing revealed a novel heterozygous variant c.278G>T (p.W93L) in OTX2 in the proband. All affected members as well as the unaffected mother of the proband carried the same variant.Conclusion: Syndromic microphthalmia due to mutations in OTX2 can present with significant intrafamilial phenotypic variability.
title: Dimensionen des laryngo-trachealen Überganges im MRT gemäß einer epidemiologischen Kohorte
Creators: name: Schmidt, Catherine
name: Ivanovska, Tanja
name: Völzke, Henry
name: Langner, Sönke
name: Hosemann, Werner
name: Beule, Achim
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Erkrankungen des laryngo-trachealen Überganges (LTÜG) sind seltene, ernste Erkrankungen, die oftmals eine chirurgische Herausforderung bedeuten. Dabei ist aufgrund der Häufigkeit einer Intubation der Prävention eine besondere Bedeutung zuzuordnen. Daten zur chirurgisch[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
A new anthraquinone and a new naphthoquinone from the whole plant of Spermacoce latifolia
Creators: name: Luo, Ying
name: Shen, Hai-Yan
name: Shen, Qing-Xiang
name: Cao, Zhao-Hui
name: Zhang, Min
name: Long, Shi-Yin
name: Wang, Zong-Bao
name: Tan, Jian-Wen
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Virology

description: A phytochemical study on the whole plant of Spermacoce latifolia led to the isolation of a new anthraquinone, 1,2,6-trihydroxy-5-methoxy-9,10-anthraquinone (1), and a new naphthoquinone, (2R)-6-hydroxy-7-methoxy-dehydroiso-α-lapachone (2), together with three known anthraquinones (3–5). Their structures were established on the basis of detailed spectroscopic analysis, including one- and two-dimensional NMR, ESI–MS, and HR–ESI–MS techniques. All the compounds were isolated from S. latifolia for the first time. Compounds 1, 2, 4, and 5 showed significant antibacterial activity toward Bacillus subtilis with MIC values ranging from 0.9 to 31.2 μg/ml, and compound 4 aslo exhibited antibacterial activity against Bacillus cereus with a MIC value 62.5 μg/ml. Compound 1 was further revealed to show significant in vitro α-glucosidase inhibitory activity with IC50 value of 0.653 mM.
Design of perylene-diimides-based small-molecules semiconductors for organic solar cells
Creators: name: Jin, Ruifa
name: Wang, Fengxin
name: Guan, Ruijie
name: Zheng, Xiaomin
name: Zhang, Tao
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: A series of perylene-diimide-based small molecules have been designed to explore their optical, electronic and charge transport properties as organic solar cell materials. The frontier molecular orbitals analysis has turned out that the vertical electronic transitions of absorption are characterised as intramolecular charge transfer between perylene diimide moieties and substituent aromatic groups. Our results suggest that the optical and electronic properties and reorganisation energies are affected by the introduction of different aromatic groups to these molecules. The calculation results showed that the designed molecules own the large longest wavelength of absorption spectrum, the oscillator strength and absorption region values. On the basis of the investigated results, the designed molecules could be used as solar cell material with intense broad absorption spectra. Furthermore, they are expected to be the promising candidates for hole and/or electron transport materials.
title: Dimensionen Trachea im MRT gemäß einer epidemiologischen Kohorte
Creators: name: Beule, Achim
name: Schmidt, Catherine
name: Völzke, Henry
name: Langner, Sönke
name: Hosemann, Werner
name: Ivanovska, Tanja
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Erkrankungen der Trachea sind ernste Erkrankungen, die oftmals eine chirurgische Herausforderung bedeuten. Sie entstehen als Folge von Schilddrüsenerkrankungen oder auch nach Tracheotomie oder Intubation. Ziel der hier vorgelegten Untersuchung war es, ein reliables Messprotokoll und[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Long-term trends in airborne SO2 in an air quality monitoring station in Seoul, Korea, from 1987 to 2013
Creators: name: Azmatullah Khan
name: Kim, Ki-Hyun
name: Szulejko, Jan E.
name: Brown, Richard J. C.
name: Eui-Chan Jeon
name: Oh, Jong-Min
name: Shin, Yong Soon
name: Adedeji A. Adelodun
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Science Policy

description: Atmospheric concentration of sulfur dioxide (SO2) was intermittently measured at an air quality monitoring (AQM) station in the Yong-san district of Seoul, Korea, between 1987 and 2013. The SO2 level was compared with other important pollutants concurrently measured, including methane (CH4), carbon monoxide (CO), nitric oxide (NO), nitrogen dioxide (NO2), ozone (O3), and particulate matter (PM10). If split into three different periods (period 1, 1987–1988, period 2, 1999–2000, and period 3, 2004–2013), the respective mean [SO2] values (6.57 ± 4.29, 6.30 ± 2.44, and 5.29 ± 0.63 ppb) showed a slight reduction across the entire study period. The concentrations of SO2 are found to be strongly correlated with other pollutants such as CO (r = 0.614, p = 0.02), which tracked reductions in reported emissions due to tighter emissions standards enacted by the South Korean government. There was also a clear seasonal trend in the SO2 level, especially in periods 2 and 3, reflecting the combined effects of domestic heating by coal briquettes and meteorological conditions. Although only a 16% concentration reduction was achieved during the 27-year study duration, this is significant if one considers rapid urbanization, an 83.2% increase in population, and rapid industrialization that took place during that period. Implications: Since 1970, a network of air quality monitoring (AQM) stations has been operated by the Korean Ministry of Environment (KMOE) for routine nationwide monitoring of air pollutant concentrations in urban/suburban areas. To date, the information obtained from these stations has provided a platform for analyzing long-term trends of major pollutant species. In this study, we examined the long-term trends of SO2 levels and relevant environmental parameters monitored continuously in the Yong-san district of Seoul between 1987 and 2013. The data were analyzed over various time scales (i.e., monthly, seasonal, and annual intervals). The results obtained from this study will allow us to assess the effectiveness of abatement strategy and to predict future concentrations trends in association with future abatement strategies and technologies.
title: DVT-Röntgen in der Routine einer HNO-Klinik
Creators: name: Kempf, Hans-Georg
name: Dikta, Kai
name: Lehnerdt, Götz
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die digitale Volumentomografie (DVT) ist ein modernes, 3-dimensionales Röntgenschnittbildverfahren mit geringerer Strahlenexposition gegenüber der Computertomografie. Im Rahmen einer prospektiv geführten Analyse wurden über 7 Monate das Patientengut bzgl. Indikation und[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Deficiency in DNA damage response, a new characteristic of cells infected with latent HIV-1
Creators: name: Piekna-Przybylska, Dorota
name: Gaurav Sharma
name: Maggirwar, Sanjay B.
name: Bambara, Robert A.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: FOS: Biological sciences

description: Viruses can interact with host cell molecules responsible for the recognition and repair of DNA lesions, resulting in dysfunctional DNA damage response (DDR). Cells with inefficient DDR are more vulnerable to therapeutic approaches that target DDR, thereby raising DNA damage to a threshold that triggers apoptosis. Here, we demonstrate that 2 Jurkat-derived cell lines with incorporated silent HIV-1 provirus show increases in DDR signaling that responds to formation of double strand DNA breaks (DSBs). We found that phosphorylation of histone H2AX on Ser139 (gamma-H2AX), a biomarker of DSBs, and phosphorylation of ATM at Ser1981, Chk2 at Thr68, and p53 at Ser15, part of signaling pathways associated with DSBs, are elevated in these cells. These results indicate a DDR defect even though the virus is latent. DDR-inducing agents, specifically high doses of nucleoside RT inhibitors (NRTIs), caused greater increases in gamma-H2AX levels in latently infected cells. Additionally, latently infected cells are more susceptible to long-term exposure to G-quadruplex stabilizing agents, and this effect is enhanced when the agent is combined with an inhibitor targeting DNA-PK, which is crucial for DSB repair and telomere maintenance. Moreover, exposing these cells to the cancer drug etoposide resulted in formation of DSBs at a higher rate than in un-infected cells. Similar effects of etoposide were also observed in population of primary memory T cells infected with latent HIV-1. Sensitivity to these agents highlights a unique vulnerability of latently infected cells, a new feature that could potentially be used in developing therapies to eliminate HIV-1 reservoirs.
Synthesis and biological activity of novel sulfone derivatives containing a [1,2,4]triazolo[4,3-a]pyridine moiety
Creators: name: Xu, Fang-Zhou
name: Wang, Yan-Yan
name: Zhu, Yun-Ying
name: Shao, Jia-Hui
name: Yu, Gang
name: Xue, Wei
name: Wu, Jian
name: Wu, Hui-Bing
name: Shi, Jun
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences

description: A series of novel sulfone derivatives containing a [1,2,4]triazolo[4,3-a]pyridine moiety was synthesized and characterized via 1H NMR, 13C NMR, IR, and elemental analyses. Bioassay results indicated some of the derivatives displayed good antifungal activities and insecticidal activity. The inhibition rates of 8-chloro-3-((2,6-difluorobenzyl)sulfonyl)-[1,2,4]triazolo[4,3-a]pyridine against Rhizotonia erealis and Helminthosporium maydis were 78.6% and 76.4% activities at 50 μg mL−1, respectively. And compound 8-chloro-3-(((6-chloropyridin-3-yl)methyl)sulfonyl)-[1,2,4]triazolo[4,3-a]pyridine showed >95% mortality at 500 μg mL−1 and >65% mortality at 200 μg mL−1 against Plutella xylostella, respectively. As well as 8-chloro-3-(((6-chloropyridin-3-yl)methyl)sulfonyl)-[1,2,4]triazolo[4,3-a]pyridine displayed >90% mortality at 500 μg mL−1 against Helicoverpa armigera. A preliminary structure activity relationship (SAR) is discussed.
A study of the beam-specific interplay effect in proton pencil beam scanning delivery in lung cancer
Creators: name: Kang, Minglei
name: Huang, Sheng
name: D. Solberg, Timothy
name: Mayer, Rulon
name: Thomas, Andy
name: Teo, Boon-Keng Kevin
name: McDonough, James E.
name: Simone, Charles B.
name: Lin, Liyong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Background: For lung tumors with large motion amplitudes, the use of proton pencil beam scanning (PBS) can produce large dose errors. In this study, we assess under what circumstances PBS can be used to treat lung cancer patients who exhibit large tumor motion, based on the quantification of tumor motion and the dose interplay. Material and methods: PBS plans were optimized on average 4DCT datasets using a beam-specific PTV method for 10 consecutive patients with locally advanced non-small-cell-lung-cancer (NSCLC) treated with proton therapy to 6660/180 cGy. End inhalation (CT0) and end exhalation (CT50) were selected as the two extreme scenarios to acquire the relative stopping power ratio difference (Δrsp) for a respiration cycle. The water equivalent difference (ΔWET) per radiological path was calculated from the surface of patient to the iCTV by integrating the Δrsp of each voxel. The magnitude of motion of voxels within the target follows a quasi-Gaussian distribution. A motion index (MI (>5mm WET)), defined as the percentage of target voxels with an absolute integral ΔWET larger than 5 mm, was adopted as a metric to characterize interplay. To simulate the treatment process, 4D dose was calculated by accumulating the spot dose on the corresponding respiration phase to the reference phase CT50 by deformable image registration based on spot timing and patient breathing phase. Results: The study indicated that the magnitude of target underdose in a single fraction plan is proportional to the MI (p < .001), with larger motion equating to greater dose degradation and standard deviations. The target homogeneity, minimum, maximum and mean dose in the 4D dose accumulations of 37 fractions varied as a function of MI. Conclusions: This study demonstrated that MI can predict the level of dose degradation, which potentially serves as a clinical decision tool to assess whether lung cancer patients are potentially suitable to receive PBS treatment.
title: Ein klinischer Algorithmus für Patienten im höheren Lebensalter mit Tumorerkrankungen im Kopf-Hals-Bereich
Creators: name: Höing, Benedikt
name: Lang, Stephan
name: Stuschke, Martin
name: Hussain, Timon
name: Kanaan, Oliver
name: Hansen, Stefan
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Die Therapie von Kopf-Hals-Tumoren ist durch chirurgische und radiochemotherapeutische Verfahren geprägt, die teilweise eine hohe Morbidität nach sich ziehen. Bei älteren Patienten sieht sich der HNO-Arzt häufig mit der Frage der Sinnhaftigkeit einer invasiven Therapie[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Testing of fractional Brownian motion in a noisy environment
Creators: name: Balcerek, Michal
name: Burnecki, Krzysztof
Publisher: name: arXiv
Year: 2019
Subjects: subject: Statistics Theory (math.ST)
subject: Methodology (stat.ME)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: Fractional Brownian motion (FBM) is the only Gaussian self-similar process with stationary increments. Its increment process, called fractional Gaussian noise, is ergodic and exhibits a property of power-like decaying autocorrelation function (ACF) which leads to the notion of long memory. These properties have made FBM important in modelling real-world data recorded in different experiments ranging from biology to telecommunication. These experiments are often disturbed by a noise which source can be just the instrument error. In this paper we propose a rigorous statistical test based on the ACF for FBM with added white Gaussian noise. To this end we derive a distribution of the test statistic which is given explicitly by the generalized chi-squared distribution. This allows us to find critical regions for the test with a given significance level. We check the quality of the introduced test by studying its power and comparing with other tests existing in the literature. We also note that the introduced test procedure can be applied to an arbitrary Gaussian process.
description: 25 pages, 6 figures
title: Ein Schuss in den Hals und seine Konsequenzen
Creators: name: Fratric, Darko
name: Folz, Benedikt Josef
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Der Artikel bewertet das Attentat des Erzherzogs Franz Ferdinand von Habsburg und seiner Frau, der Herzogin Sophie in Sarajevo als das auslösende Ereignis des Ersten Weltkriegs. Bis heute sind die Ursachen des Ersten Weltkriegs ein Thema von immmensem historischem Interesse und Bedeutung. In diesem[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
An optimization model for water quantity and quality integrated management of an urban lake in a water deficient city
Creators: name: Zheng, Jian-Feng
name: Jiao, Ji-Dong
name: Zhang, Shuo
name: Sun, Li-Ping
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plasma Physics

description: This paper presents an optimization model for water quantity and quality integrated management of an urban lake in a water deficient city. A representative water quantity and quality safeguard system served urban lake, including multi-source water supply facilities, recirculating water purification facilities and surplus water discharge facilities, is widely used in Chinese water deficient cities. Because it is complicated, any mismanagement will result in water quality deterioration, water waste and high operation cost. The presented model attempts to achieve the objectives of controlling water pollution, reducing economic cost and improving water utilization efficiency through an optimized operating water safeguard system. The model is applied to Qingjing Lake in Tianjin, China. Results show that the model plays a more positive role for water quantity and quality integrated management.