Additional file 1 of Development and validation of AI-derived segmentation of four-chamber cine cardiac magnetic resonance
Creators: name: Assadi, Hosamadin
name: Alabed, Samer
name: Li, Rui
name: Matthews, Gareth
name: Karunasaagarar, Kavita
name: Kasmai, Bahman
name: Nair, Sunil
name: Mehmood, Zia
name: Grafton-Clarke, Ciaran
name: Swoboda, Peter P.
name: Swift, Andrew J.
name: Greenwood, John P.
name: Vassiliou, Vassilios S.
name: Plein, Sven
name: van der Geest, Rob J.
name: Garg, Pankaj
Publisher: name: figshare
Year: 2024
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Supplementary Material 1: Table S1. Normal distribution test for CMR variables with the reference manual segmentation. Shapiro–Wilk test (a significant p-value demonstrates not normally distributed data). Table S2. AI repeatability results of fully automated four-chamber CMR analysis. Table S3. CMR characteristics, correlation and Bland-Altman results of AI-generated four-chamber and short-axis segmentations. Table S4. CMR characteristics, correlation and Bland-Altman results of AI-generated four-chamber and short-axis segmentations after applying the correction factor (LV = 14.5623 mL; RV = 50.7676 mL). Table S5. Quality control assessment of the external validation cohort (n = 101). Table S6. Left and right heart CMR functional assessment by manual analysis. Table S7. Left and right heart CMR functional assessment by automated analysis. Table S8. Univariable and stepwise multivariable Cox regression analysis of all four chambers by manual examination. Table S9. Univariable and stepwise multivariable Cox regression analysis of all four chambers by automated analysis. Fig. S1. Bland-Altman plots demonstrating the degree of agreement between manual segmentation and AI four-chamber analysis of the left atrium and left ventricle. (a) LA EDV left atrial enddiastolic volume. (b) LA ESV left atrial end-systolic volume. (c) LA SV left atrial systolic volume. (d) LA EF left atrial ejection fraction. (e) LV EDV left ventricular end-diastolic volume. (f) LV ESV left ventricular end-systolic volume. (g) LV SV left ventricular systolic volume. (h) LV EF left ventricular ejection fraction. Fig. S2. Bland-Altman plots demonstrating the degree of agreement between manual segmentation and AI four-chamber analysis of the right atrium (a, b, c, d) and right ventricle (e, f, g, h). (a) RA EDV right atrial end-diastolic volume. (b) RA ESV right atrial end-systolic volume. (c) RA SV right atrial systolic volume. (d) RA EF right atrial ejection fraction. (e) RV EDV right ventricular end-diastolic volume. (f) RV ESV right ventricular end-systolic volume. (g) RV SV right ventricular systolic volume. (h) RV EF right ventricular ejection fraction. Fig. S3. Bland-Altman plots demonstrating the degree of agreement between AI-generated fourchamber and short-axis segmentations. (a) LV EDV left ventricular end-diastolic volume. (b) LV ESV left ventricular end-systolic volume. (c) LV SV left ventricular systolic volume. (d) LV EF left ventricular ejection fraction. (e) RV EDV right ventricular end-diastolic volume. (f) RV ESV right ventricular endsystolic volume. (g) RV SV right ventricular stroke volume. (h) RV EF right ventricular ejection fraction. Fig. S4. Bland-Altman plots demonstrating the degree of agreement between AI-generated fourchamber and short-axis segmentations after applying the correction factor (LV = 14.5623 mL; RV = 50.7676 mL). (a) LV EDV left ventricular end-diastolic volume. (b) LV ESV left ventricular end-systolic volume. (c) RV EDV right ventricular end-diastolic volume. (d) RV ESV right ventricular end-systolic volume