cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Pricing methods in outcome-based contracting: δ4: Safety-based pricing
Creators: name: Nimer S. Alkhatib
name: Sandipan Bhattacharjee
name: McBride, Ali
name: Ramos, Kenneth
name: Slack, Marion
name: Erstad, Brian
name: Abraham, Ivo
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences

description: Aims: Six Delta is a six-dimensional independent platform for outcome-based pricing/contracting. The fourth dimension (δ4) estimates prices on the basis of assessments of the safety of the drug using an ex ante analysis based on clinical trial data. We describe this dimension’s methodology and present a proof-of-concept application to the treatment of non-small cell lung cancer (NSCLC) with EGFR mutation with osimertinib. Materials and methods: The safety-based pricing dimension utilizes a four-step method: 1) pooling adverse events (AE), standardizing, estimating 95%CIs, and adjusting for time; 2) estimating correction factors and corrected probabilities of AEs; 3) estimating the probability of at least one adverse event (AE) occurring and leading to treatment discontinuation; and 4) estimating ranges for payback percentages and performing Monte Carlo Simulation to estimate a DSPSafety. A proof-of-concept exercise with osimertinib in NSCLC was performed for two hypothetical outcome-based contracts: 1-year (2019-2020) and 2-year (2019-2021). We estimated the DSPSafety based on the grade 3/4 AEs observed for osimertinib and standard of care. The 2018 wholesale acquisition cost (WAC) of osimertinib at $14,616 for a 30-day prescription was used. Results: AEs3/4 were retrieved from the FLAURA trial. In the 1-year contract, the DSPSafety of osimertinib was estimated at $14,627 (or +0.08% the 2018 WAC) for a 30-day prescription. In the 2-year contract, the DSPSafety of osimertinib was estimated at $14,516 (or −0.68% the 2018 WAC) for a 30-day prescription. Conclusions: We demonstrated that ex ante pricing methods-based paybacks for safety issues leading to treatment discontinuation can be integrated into our proposed Six Delta platform for outcome-based pricing/contracting.
Clinical performance of a specific granulocyte colony stimulating factor ELISA to determine its concentration in follicular fluid as a predictor of implantation success during in vitro fertilization
Creators: name: H. Tournaye
name: T. D’Hooghe
name: G. Verheyen
name: K. F. Devreker
name: S. Perrier D’Hauterive
name: M. Nisolle
name: J.-M. Foidart
name: C. Munaut
name: L. Noel
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: This study aimed to demonstrate the clinical performance of an ultra-sensitive follicular fluid (FF) granulocyte colony stimulating factor (G-CSF) immunoassay to confirm previous work, indicating a correlation between FF G-CSF concentration and live birth potential of the corresponding embryo after in vitro fertilization. This study was a noninterventional, prospective, diagnostic clinical multicentric study conducted between August 2012 and January 2014 with 396 single embryo transfers (SETs) from 278 subjects. During oocyte retrieval, FF was individually collected. Embryo morphology and implantation success were evaluated. The implantation success rate in the high G-CSF group (32.3%) was higher than the overall rate (27.5%). Similarly, for embryos with optimal morphology, implantation success rates were highest among those in the high G-CSF concentration category (34.5%) compared with low (19.6%) and intermediate (29.8%) G-CSF concentration categories. Significant differences in mean G-CSF concentrations were observed between the study sites. To minimize bias, analyses were repeated using data from the center with the largest number of SETs. In alignment with the overall analysis, this center demonstrated a 43% greater probability of implantation for optimal embryos with high G-CSF compared to the general implantation rate among optimal embryos and a 327% increase compared with the implantation rate of optimal embryos with low G-CSF. Trial registration:ClinicalTrials.gov identifier: NCT02593513. Trial registration:ClinicalTrials.gov identifier: NCT02593461. Trial registration:ClinicalTrials.gov identifier: NCT02586272.
Scaling analysis of electron transport through metal-semiconducting carbon nanotube interfaces: Evolution from the molecular limit to the bulk limit
Creators: name: Xue, Yongqiang
name: Ratner, Mark A.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We present a scaling analysis of electronic and transport properties of metal-semiconducting carbon nanotube interfaces as a function of the nanotube length within the coherent transport regime, which takes fully into account atomic-scale electronic structure and three-dimensional electrostatics of the metal-nanotube interface using a real-space Green's function based self-consistent tight-binding theory. As the first example, we examine devices formed by attaching finite-size single-wall carbon nanotubes (SWNT) to both high- and low- work function metallic electrodes through the dangling bonds at the end. We analyze the nature of Schottky barrier formation at the metal-nanotube interface by examining the electrostatics, the band lineup and the conductance of the metal-SWNT molecule-metal junction as a function of the SWNT molecule length and metal-SWNT coupling strength. We show that the confined cylindrical geometry and the atomistic nature of electronic processes across the metal-SWNT interface leads to a different physical picture of band alignment from that of the planar metal-semiconductor interface. We analyze the temperature and length dependence of the conductance of the SWNT junctions, which shows a transition from tunneling- to thermal activation-dominated transport with increasing nanotube length. The temperature dependence of the conductance is much weaker than that of the planar metal-semiconductor interface due to the finite number of conduction channels within the SWNT junctions. We find that the current-voltage characteristics of the metal-SWNT molecule-metal junctions are sensitive to models of the potential response to the applied source/drain bias voltages.
description: Minor revision to appear in Phys. Rev. B. Color figures available in the online PRB version or upon request to: yxue@uamail.albany.edu
Supersymmetric Intersecting D6-branes and Fluxes in Massive Type IIA String Theory
Creators: name: Behrndt, Klaus
name: Cvetic, Mirjam
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study N=1 supersymmetric four-dimensional solutions of massive Type IIA supergravity with intersecting D6-branes in the presence NS-NS three-form fluxes. We derive N=1 supersymmetry conditions for the D6-brane and flux configurations in an internal manifold $X_6$ and derive the intrinsic torsion (or SU(3)-structure) related to the fluxes. In the absence of fluxes, N=1 supersymmetry implies that D6-branes wrap supersymmetric three-cycles of $X_6$ that intersect at angles of SU(3) rotations and the geometry is deformed by SU(3)-structures. The presence of fluxes breaks the SU(3) structures to SU(2) and the D6-branes intersect at angles of SU(2) rotations; non-zero mass parameter corresponds to D8-branes which are orthogonal to the common cycle of all D6-branes. The anomaly inflow indicates that the gauge theory on intersecting (massive) D6-branes is not chiral.
description: 31 pages, Latex, small changes, add refs
Additional file 1 of Sulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary intervention with whole foods and amino acid supplements
Creators: name: Stolt, Emma
name: Olsen, Thomas
name: Amany Elshorbagy
name: Kožich, Viktor
name: Van Greevenbroek, Marleen
name: Øvrebø, Bente
name: Thoresen, Magne
name: Refsum, Helga
name: Retterstøl, Kjetil
name: Vinknes, Kathrine J.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. SPIRIT checklist 2013: Recommended items to address in clinical trial protocol and related documents*.
Cost utility analysis of tisagenlecleucel vs salvage chemotherapy in the treatment of relapsed/refractory diffuse large B-cell lymphoma from Singapore’s healthcare system perspective
Creators: name: Boon Piang Cher
name: Kar Yee Gan
name: Aziz, Mohamed Ismail Abdul
name: Lin, Liang
name: Hwang, William Ying Khee
name: Poon, Li Mei
name: Kwong Ng
Publisher: name: Taylor & Francis
Year: 2020
Subjects: Medicine
Pharmacology
Biotechnology
Cancer
Science Policy

description: Background: Patients with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL) have limited treatment options and poor prognoses. Tisagenlecleucel, a chimeric antigen receptor (CAR) T-cell therapy has shown early promise in improving survival outcomes, but at a high upfront cost. This study evaluated the cost-effectiveness of tisagenlecleucel versus salvage chemotherapy for treating patients with r/r DLBCL who have failed at least 2 lines of systemic therapies. Methods: A hybrid decision tree and three-state partitioned survival model (progression-free (PF), progressive disease and death) was developed from the Singapore healthcare payer perspective. Survival curves from JULIET trial and CORAL-1 extension study were extrapolated beyond trial period over a 15-year time horizon to estimate the underlying progression-free survival and overall survival parametric distributions for both arms. Health state utilities were retrieved from the literature, and direct costs were sourced from public healthcare institutions in Singapore. One-way probabilistic sensitivity analyses and scenario analyses were conducted to explore the impact of uncertainties and assumptions on cost-effectiveness results. Results: Compared with salvage chemotherapy, tisagenlecleucel was associated with a base-case incremental cost-effectiveness ratio (ICER) US$508,530 (S$686,516) per quality adjusted life year (QALY) gained and US$320,200 (S$432,269) per life year (LY) gained. One-way sensitivity analysis showed the ICER was most sensitive to time horizon, PF utility and cost of tisagenlecleucel. Scenario analyses confirmed that the ICERs remained high under favorable assumptions and substantial price reduction was required to reduce the ICER. Conclusions: Our analysis showed tisagenlecleucel use in r/r DLBCL patients who failed at least 2 prior lines of systemic therapies was associated with exceedingly high ICER, which is unlikely to represent good use of healthcare resources. Comparative clinical evidence from the ongoing trials might provide more insight into future evaluations.
Are digital natives spreadsheet natives?
Creators: name: Csernoch, Maria
name: Biró, Piroska
Publisher: name: arXiv
Year: 2019
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: The present paper reports the results of testing first year students of Informatics on their algorithmic skills and knowledge transfer abilities in spreadsheet environments. The selection of students plays a crucial role in the project. On the one hand, they have officially finished their spreadsheet training - they know everything - while on the other hand, they do not need any training, since they are digital natives, to whom digital skills are assigned by birth. However, we found that the students had serious difficulties in solving the spreadsheet problems presented: so low were their results that it allowed us to form broad tendencies. Considering computational thinking, algorithmic skills, and knowledge transfer abilities, it is clear that those students performed better who used algorithm-based, multilevel array formulas instead of problem specific, unconnected built-in functions. Furthermore, we can conclude that students, regardless of their birth date and digital generation assigned to them, are in great need of official, high-mathability, algorithm-based training with expert teachers.
description: 13 Pages, 6 Colour Figures, 9 Tables. First Presented at the EuSpRIG 2018 conference, Imperial College, London
Additional file 4 of High-dose opioid utilization and mortality among individuals initiating hemodialysis
Creators: name: Daubresse, Matthew
name: G. Caleb Alexander
name: Crews, Deidra C.
name: Dorry L. Segev
name: Lentine, Krista
name: McAdams-DeMarco, Mara A.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 60506 Virology
subject: Computational Biology

description: Additional file 4: Supplemental Table 4. Risk of mortality associated with opioid utilization among adults initiating hemodialysis before and after 365 days, 2007–2014*.
Pricing methods in outcome-based contracting: δ6: adherence-based pricing
Creators: name: Nimer S. Alkhatib
name: Slack, Marion
name: Sandipan Bhattacharjee
name: Erstad, Brian
name: Ramos, Kenneth
name: McBride, Ali
name: Abraham, Ivo
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: Six Delta is a six-dimensional independent platform for outcome-based pricing/contracting. The sixth dimension (δ6) estimates prices on the basis of adherence to the prescribed regimen, whereby manufacturers provide payers with adherence-enhancing programs and whereby payers implement these programs and provide adherence data to the manufacturer. We describe this dimension’s methodology and present a proof-of-concept application to the treatment of non-small cell lung cancer (NSCLC) with EGFR mutation with osimertinib. We propose two paybacks based on adherence: in-advance (based on clinical trial data) and in-arrear (based on real-world data). The risk of efficacy failure pricing dimension utilizes a 7-step method: 1) defining efficacy endpoints; 2) extracting data; 3) predicting models; 4) estimating in-advance and in-arrear paybacks; 5) suggesting ranges for in-advance and in-arrear paybacks; 6) adjusting for medical inflation; and 7) performing Monte Carlo Simulation (MCS) to estimate the DSPAdherence. A proof-of-concept exercise with osimertinib in NSCLC was performed for two hypothetical outcome-based contracts: 1-year (2019–2020) and 2-year (2019–2021). The 2018 wholesale acquisition cost (WAC) for a 30-day prescription was used and inflated as needed. Herein, the DSPAdherence is estimated exclusively in terms of in-advance payback because real-world data about osimertinib are not yet available and thus the in-arrear payback cannot yet be estimated. For the 1-year contract, the average price for osimertinib was $13,798 (SD=$1,265) and the DSPAdherence was $13,785 (or −5.69% of the 2018 WAC) for a 30-day prescription. For the 2-year contract, the average price was $12,555 (SD=$2,847) and the DSPAdherence was $12,582 (or −13.92% of the 2018 WAC). We demonstrated that adherence-based pricing methods can be integrated into our proposed Six Delta platform for outcome-based pricing/contracting. The proof-of-concept exercise needs to be expanded with the in-arrear pricing method based on real world data to be secured.
Additional file 5 of High-dose opioid utilization and mortality among individuals initiating hemodialysis
Creators: name: Daubresse, Matthew
name: G. Caleb Alexander
name: Crews, Deidra C.
name: Dorry L. Segev
name: Lentine, Krista
name: McAdams-DeMarco, Mara A.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 60506 Virology
subject: Computational Biology

description: Additional file 5: Supplemental Table 5. Risk of mortality associated with opioid dose among adults with ≥1 claims for comorbid conditions of interest one year prior to hemodialysis initiation, 2007–2014* (N = 245,107).
Within-talus temperatures are not limiting for pikas in the northern Sierra Nevada, California, USA
Creators: name: Wright, David H.
name: Stewart, Joseph
Publisher: name: figshare
Year: 2020
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 50101 Ecological Impacts of Climate Change
subject: FOS: Earth and related environmental sciences

description: The American pika (Ochotona princeps) is a temperature-sensitive lagomorph reported to be in decline in warmer sites in California, Nevada and portions of Utah. Talus is used for denning and retreat habitat by the species. Climate envelope modeling and climate projections suggest the species’ distribution will retract in coming decades—but other studies suggest pikas may be resilient in the face of warming by taking advantage of talus as a thermal refuge from warming air temperatures. We investigated the thermal environment of mid to low elevation talus habitats in the northern Sierra Nevada between 2010 and 2012 using automated temperature loggers placed generally 0.5 to 1 m below the talus surface. We found temperatures within talus are rarely challenging to pikas—even in taluses well below the inhabited elevational range of pikas. Occurrence of temperature extremes within talus was only weakly correlated with elevation, and exhibited substantial variation between talus patches. Temperatures deeper in talus than we were able to probe but that pikas can likely reach are certain to be even more stable and less physiologically challenging. Despite buffered temperatures in the subsurface talus environment, we observed multiple instances of pika-accessible, previously inhabited talus patches that did not support pikas in our surveys. Summer daily maximum air temperatures at these taluses averaged more than 2°C warmer than occupied taluses, and taluses that pikas occupied in some years but not in others were intermediate in temperature. Sites with no evidence of past pika occupancy averaged warmest of all. We suggest above ground air and surface temperatures, rather than temperatures within talus, pose a greater challenge to pika persistence, through effects on foraging and dispersal. Our results indicate that the thermal refuge provided by talus is likely to be necessary and beneficial to American pikas, but sufficient only to partially offset the ongoing impacts of warming ambient temperatures on waning pika distribution.
Amaurochrous ovalis Barber & Sailer 1953
Creators: name: Rider, David A.
name: Swanson, Daniel R.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Pentatomidae
Amaurochrous
Amaurochrous ovalis

description: Amaurochrous ovalis Barber & Sailer, 1953
 Distribution: Canada: ON (Paiero et al. 2003). United States: NC, NJ (Slater & Baranowski 1970), SC.
description: Published as part of Rider, David A. & Swanson, Daniel R., 2021, A distributional synopsis of the Pentatomidae (Heteroptera) north of Mexico, including new state and provincial records, pp. 1-69 in Zootaxa 5015 (1) on page 47, DOI: 10.11646/zootaxa.5015.1.1, http://zenodo.org/record/5159085
In situ measurements of the variable slow solar wind near sector boundaries
Creators: name: Sanchez-Diaz, E.
name: Rouillard, A.
name: Lavraud, B.
name: Kilpua, E.
name: Davies, J.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: The release of density structures at the tip of the coronal helmet streamers, likely as a consequence of magnetic reconnection, contributes to the mass flux of the slow solar wind. In situ measurements in the vicinity of the heliospheric plasma sheet of the magnetic field, protons and suprathermal electrons reveal details of the processes at play during the formation of density structures near the Sun. In a previous article, we exploited remote-sensing observations to derive a 3-D picture of the dynamic evolution of a streamer. We found evidence of the recurrent and continual release of dense blobs from the tip of the streamers. In the present paper, we interpret in situ measurements of the slow solar wind during solar maximum. Through both case and statistical analysis, we show that in situ signatures (magnetic field magnitude, smoothness and rotation, proton density and suprathermal electrons, in the first place) are consistent with the helmet streamers producing, in alternation, high-density regions (mostly disconnected) separated by magnetic flux ropes (mostly connected to the Sun). This sequence of emission of dense blobs and flux ropes also seems repeated at smaller scales inside each of the high-density regions. These properties are further confirmed with in situ measurements much closer to the Sun using Helios observations. We conclude on a model for the formation of dense blobs and flux ropes that explains both the in situ measurements and the remote-sensing observations presented in our previous studies.
TableS1.xlsx
Creators: name: Zhenguo Zhang
Publisher: name: figshare
Year: 2020
Subjects: subject: Geophysics
subject: FOS: Earth and related environmental sciences

description: Table S1. The catalog of earthquakes generated by dynamic rupture simulations. For each earthquake, we list its dimensionless parameters. To make it better understood, we give the seismic moment M0 and magnitude Mw of each earthquake in the case of implementing the breakdown stress drop Tu= 18.24 MPa, the effective radius of the nucleation patch Ra = 1692.6 m, which are from the TPV3 model released by SCEC (refer to the interpretation in the main text).
Pricing methods in outcome-based contracting: δ1: cost effectiveness analysis and cost-utility analysis-based pricing
Creators: name: Nimer S. Alkhatib
name: Ramos, Kenneth
name: Erstad, Brian
name: Slack, Marion
name: McBride, Ali
name: Sandipan Bhattacharjee
name: Abraham, Ivo
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences

description: Six Delta is a six-dimensional independent platform for outcome-based pricing/contracting. The first dimension (δ1) estimates prices on the basis of cost-effectiveness (CEA) and cost-utility analysis (CUA). We describe this dimension’s methodology and present a proof-of-concept application to the treatment of non-small cell lung cancer (NSCLC) with EGFR mutation with osimertinib. CEA and CUA were performed using established methods. Probabilistic sensitivity analyses (PSA) were performed to generate cost-effectiveness acceptability curves (CEAC), specifically the PSA incremental cost-effectiveness (PSA ICER) and incremental cost-utility ratio generated CEACs (PSA ICUR). Price of treatment was estimated at three certainty levels (0%, turning point%, 100%). The marketed drug price at turning point was used to estimate prices at 0% and 100% certainty levels, as per PSA ICER and PSA ICUR-generated CEACs. The resulting prices were pooled, inflated, and simulated by Monte Carlo Simulation (MCS) methods to estimate the dimension-specific price based on CEA and CUA (DSPCEA/CUA). A proof-of-concept exercise with osimertinib in NSCLC was performed for two hypothetical outcome-based contracts: 1-year (2019–2020) and 2-years (2019–2021). Turning points were estimated at the 50% certainty level in both PSA ICER and ICUR-generated CEACS. At these points, the wholesale acquisition cost for osimertinib was $14,616 (30-day prescription); inflated by 0.44% for 1-year and by 0.72% for 2-year contracts. Additional prices at 0% and 100% certainty levels were quantified based on the PSA ICER and ICUR-generated CEACs. The MCS yielded a DSPCEA/CUA of $16,391 for the 1-year contract and a DSPCEA/CUA at $16,677 for the 2-year contract for a 30-day prescription. We demonstrated that conventional CEA and CUA methods generate price estimates at varying levels of certainty that can be integrated into our proposed Six Delta platform for outcome-based pricing/contracting.
Full counting statistics of incoherent Andreev transport
Creators: name: Belzig, W.
name: Samuelsson, P.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the full counting statistics of heterostructures consisting of normal metal parts connected to a superconducting terminal. Assuming that coherent superconducting correlations are suppressed in the normal metals we show, using Keldysh-Nambu Green's functions, that the system can be mapped onto a purely normal system with twice the number of elements. For a superconducting beam splitter with several normal terminals we obtain general results for the counting statistics.
description: 7 pages, submitted to Europhys. Lett
Additional file 1 of Quantitative comparison of SARS-CoV-2 nucleic acid amplification test and antigen testing algorithms: a decision analysis simulation model
Creators: name: Salvatore, Phillip P.
name: Shah, Melisa M.
name: Ford, Laura
name: Delaney, Augustina
name: Hsu, Christopher H.
name: Tate, Jacqueline E.
name: Kirking, Hannah L.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Additional file 1.
Effects of Kudoa septempunctata infections in a human intestinal epithelial model (Caco-2): a DNA microarray study
Creators: name: Yamamoto, So
name: Kawano, Fumi
name: Yokoyama, Hiroshi
name: Kobayashi, Shoko
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: , a myxosporean parasite infecting the trunk muscles of olive flounder (Paralichthys olivaceus), is reported to cause food poisoning in humans. The molecular mechanisms underlying the toxicity of K. septempunctata spores remain largely unknown. In the present study, we examine the molecular basis of such toxicity using DNA microarray analysis of K. septempunctata-inoculated human colon adenocarcinoma cells (Caco-2). We observed that the transepithelial resistance of the K. septempunctata-inoculated Caco-2 cell monolayers decreased markedly. DNA microarray analysis revealed that the mRNA expression profiles of control and inoculated cells clearly differed. Inflammatory and bacteria-related pathways, such as interleukin-8 (IL-8) production and MAPK/NF-kappa B pathway, were enriched. The concentrations of IL-8 and serotonin (5-HT) were higher in inoculated cells than in controls. K. septempunctata invasion damages the human intestinal epithelium, causing increased production of IL-8 and 5-HT, which likely results in the vomiting associated with K. septempunctata invasion. AP-1: activator protein 1; DAVID: Database for Annotation, Visualization and Integrated Discovery; ENS: enteric nervous system; FARMS: Factor Analysis for Robust Microarray Summarization; FDR: false discovery rate; GO: Gene Ontology; 5-HT: 5-hydroxytryptamine; IL-8: Interleukin-8; KEGG: Kyoto Encyclopedia of Genes and Genomes; K. septempunctata: Kudoa septempunctata; NF-kappa B: nuclear factor-kappa B; TJ: tight junction; TER: transepithelial electrical resistance invasion damages the human intestinal epithelium, causing increased production of IL-8 and 5-HT.
Open Ising Model Perturbed by Classical Colored Noises
Creators: name: Yu, Deshui
name: Dumke, Rainer
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We investigate the non-Markovian dynamics of an open Ising model simulated by a superconducting circuit. The quantum many-body system is weakly coupled to a white, pink- or blue-colored environment. The relaxation of the system in the strong inter-qubit interaction regime shows a metastable behaviour. In comparison with the dissipative system in the Markovian limit, the negative memory of the blue-colored noise weakens the system's relaxation. However, for the pink-colored noise the relaxation rate of the system is enhanced due to the positive memory effect. The understanding of quantum many-body systems responding to different colored noise fields is necessary for designing the environment of superconducting qubits in a large scale quantum processor.
Additional file 2 of Sulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary intervention with whole foods and amino acid supplements
Creators: name: Stolt, Emma
name: Olsen, Thomas
name: Amany Elshorbagy
name: Kožich, Viktor
name: Van Greevenbroek, Marleen
name: Øvrebø, Bente
name: Thoresen, Magne
name: Refsum, Helga
name: Retterstøl, Kjetil
name: Vinknes, Kathrine J.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2. The informed consent letter (in Norwegian).
Amaurochrous vanduzeei Barber & Sailer 1953
Creators: name: Rider, David A.
name: Swanson, Daniel R.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Pentatomidae
Amaurochrous
Amaurochrous vanduzeei

description: Amaurochrous vanduzeei Barber & Sailer, 1953
 Distribution: United States: CA, WA (Zack et al. 2014).
description: Published as part of Rider, David A. & Swanson, Daniel R., 2021, A distributional synopsis of the Pentatomidae (Heteroptera) north of Mexico, including new state and provincial records, pp. 1-69 in Zootaxa 5015 (1) on page 47, DOI: 10.11646/zootaxa.5015.1.1, http://zenodo.org/record/5159085
Upper bounds on the signed edge domination number of a graph
Creators: name: Dong, Fengming
name: Ge, Jun
name: Yang, Yan
Publisher: name: arXiv
Year: 2020
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C69

description: A signed edge domination function (or SEDF) of a simple graph $G=(V,E)$ is a function $f: E\rightarrow \{1,-1\}$ such that $\sum_{e'\in N[e]}f(e')\ge 1$ holds for each edge $e\in E$, where $N[e]$ is the set of edges in $G$ that share at least one endpoint with $e$. Let $γ_s'(G)$ denote the minimum value of $f(G)$ among all SEDFs $f$, where $f(G)=\sum_{e\in E}f(e)$.In 2005, Xu conjectured that $γ_s'(G)\le n-1$, where $n$ is the order of $G$. This conjecture has been proved for the two cases $v_{odd}(G)=0$ and $v_{even}(G)=0$, where $v_{odd}(G)$ (resp. $v_{even}(G)$) is the number of odd (resp. even) vertices in $G$. This article proves Xu's conjecture for $v_{even}(G)\in \{1, 2\}$. We also show that for any simple graph $G$ of order $n$, $γ_s'(G)\le n+v_{odd}(G)/2$ and $γ_s'(G)\le n-2+v_{even}(G)$ when $v_{even}(G)>0$, and thus $γ_s'(G)\le (4n-2)/3$. Our result improves the best current upper bound of $γ_s'(G)\le \lceil 3n/2\rceil$.
Theory of an Entanglement Laser
Creators: name: Simon, Christoph
name: Bouwmeester, Dik
Publisher: name: arXiv
Year: 2003
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We consider the creation of polarization entangled light from parametric down- conversion driven by an intense pulsed pump inside a cavity. The multi-photon states produced are close approximations to singlet states of two very large spins. A criterion is derived to quantify the entanglement of such states. We study the dynamics of the system in the presence of losses and other imperfections, concluding that the creation of strongly entangled states with photon numbers up to a million seems achievable.
description: 5 pages, 2 figures
Gravity as the affine Goldstone phenomenon and beyond
Creators: name: Pirogov, Yu. F.
Publisher: name: arXiv
Year: 2004
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The two-phase structure is imposed on the world continuum, with the graviton emerging as the tensor Goldstone boson during the spontaneous transition from the affinely connected phase to the metric one. The physics principle of metarelativity, extending the respective principle of special relativity, is postulated. The theory of metagravitation as the general nonlinear model GL(4,R)/SO(1,3) in the arbitrary background continuum is built. The concept of Metauniverse as the ensemble of the regions of the metric phase inside the affinely connected phase is introduced, and the possible bearing of the emerging multiple universes to the fine tuning of our Universe is conjectured.
description: 20 pages, style corrected
Additional file 1 of Sulfate-dependant microbially induced corrosion of mild steel in the deep sea: a 10-year microbiome study
Creators: name: Rajala, Pauliina
name: Cheng, Dong-Qiang
name: Rice, Scott A.
name: Lauro, Federico M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: Additional file 1.
Extreme Low-Frequency Ultrathin Acoustic Absorbing Metasurface
Creators: name: Donda, Krupali
name: Zhu, Yifan
name: Fan, Shi-Wang
name: Cao, Liyun
name: Li, Yong
name: Assouar, Badreddine
Publisher: name: arXiv
Year: 2019
Subjects: subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: We introduce a multi-coiled acoustic metasurface providing a quasi-perfect absorption (reaching 99.99% in experiments) at extremely low-frequency of 50 Hz, and simultaneously featuring an ultrathin thickness down to λ/527 (1.3 cm). In contrast to the state of the art, this original conceived multi-coiled metasurface offers additional degrees of freedom capable to tune the acoustic impedance effectively without increasing the total thickness. We provide analytical derivation, numerical simulation and experimental demonstrations for this unique absorber concept, and discuss its physical mechanism which breaks the quarter-wavelength resonator theory. Furthermore, based on the same conceptual approach, we propose a broadband lowfrequency metasurface absorber by coupling unit cells exhibiting different properties.
How do atomic code uncertainties affect abundance measurements in the intracluster medium?
Creators: name: Mernier, F.
name: Werner, N.
name: Lakhchaura, K.
name: de Plaa, J.
name: Gu, L.
name: Kaastra, J. S.
name: Mao, J.
name: Simionescu, A.
name: Urdampilleta, I.
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Accurate chemical abundance measurements of X-ray emitting atmospheres pervading massive galaxies, galaxy groups, and clusters provide essential information on the star formation and chemical enrichment histories of these large scale structures. Although the collisionally ionised nature of the intracluster medium (ICM) makes these abundance measurements relatively easy to derive, underlying spectral models can rely on different atomic codes, which brings additional uncertainties on the inferred abundances. Here, we provide a simple, yet comprehensive comparison between the codes SPEXACT v3.0.5 (cie model) and AtomDB v3.0.9 (vapec model) in the case of moderate, CCD-like resolution spectroscopy. We show that, in cool plasmas ($kT \lesssim 2$ keV), systematic differences up to $\sim$20% for the Fe abundance and $\sim$45% for the O/Fe, Mg/Fe, Si/Fe, and S/Fe ratios may still occur. Importantly, these discrepancies are also found to be instrument-dependent, at least for the absolute Fe abundance. Future improvements in these two codes will be necessary to better address questions on the ICM enrichment.
description: 6 pages, 2 figures, accepted for publication in Astron. Nachr. Additional material can be found here: https://github.com/mernier/SPEX_XSPEC
Association between pediatric asthma care quality and morbidity and English language proficiency in Ohio
Creators: name: Montgomery, Martha P.
name: Allen, Elizabeth D.
name: Thomas, Olivia
name: Robinson, Byron F.
name: Clark, Donnie
name: Connelly, Ann
name: Mott, Joshua A.
name: Conrey, Elizabeth
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: Limited English proficiency can be a barrier to asthma care and is associated with poor outcomes. This study examines whether pediatric patients in Ohio with limited English proficiency experience lower asthma care quality or higher morbidity. Methods: We used electronic health records for asthma patients aged 2–17 years from a regional, urban, children's hospital in Ohio during 2011–2015. Community-level demographics were included from U.S. Census data. By using chi-square and t-tests, patients with limited English proficiency and bilingual English-speaking patients were compared with English-only patients. Five asthma outcomes—two quality and three morbidity measures—were modeled using generalized estimating equations. Results: The study included 15 352 (84%) English-only patients, 1744 (10%) patients with limited English proficiency, and 1147 (6%) bilingual patients. Pulmonary function testing (quality measure) and multiple exacerbation visits (morbidity measure) did not differ by language group. Compared with English-only patients, bilingual patients had higher odds of ever having an exacerbation visit (morbidity measure) (adjusted odds ratio [aOR], 1.4; 95% confidence interval [CI], 1.2–1.6) but lower odds of admission to intensive care (morbidity measure) (aOR, 0.3; 95% CI, 0.2–0.7), while patients with limited English proficiency did not differ on either factor. Recommended follow-up after exacerbation (quality measure) was higher for limited English proficiency (aOR, 1.8; 95% CI, 1.4–2.3) and bilingual (aOR, 1.6; 95% CI, 1.3–2.1), compared with English-only patients. Conclusions: In this urban, pediatric population with reliable interpreter services, limited English proficiency was not associated with worse asthma care quality or morbidity.
Additional file 1 of Time to early initiation of postnatal care service utilization and its predictors among women who gave births in the last 2 years in Ethiopia: a shared frailty model
Creators: name: Debie, Ayal
name: Getayeneh Antehunegn Tesema
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 1. Proportional hazard assumption for the incidence of early initiation of PNC utilization and its predictors among women who gave births in the last 2 years in Ethiopia, 2016
Neapodops floridanus Slater & Baranowski 1970
Creators: name: Rider, David A.
name: Swanson, Daniel R.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Pentatomidae
Neapodops
Neapodops floridanus

description: Neapodops floridanus Slater & Baranowski, 1970
 Distribution: United States: FL.
description: Published as part of Rider, David A. & Swanson, Daniel R., 2021, A distributional synopsis of the Pentatomidae (Heteroptera) north of Mexico, including new state and provincial records, pp. 1-69 in Zootaxa 5015 (1) on page 48, DOI: 10.11646/zootaxa.5015.1.1, http://zenodo.org/record/5159085
Spin Resolution of the Electron-Gas Correlation Energy: Positive same-spin contribution
Creators: name: Gori-Giorgi, Paola
name: Perdew, John P.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: The negative correlation energy per particle of a uniform electron gas of density parameter $r_s$ and spin polarization $ζ$ is well known, but its spin resolution into up-down, up-up, and down-down contributions is not. Widely-used estimates are incorrect, and hamper the development of reliable density functionals and pair distribution functions. For the spin resolution, we present interpolations between high- and low-density limits that agree with available Quantum Monte Carlo data. In the low-density limit for $ζ= 0$, we find that the same-spin correlation energy is unexpectedly positive, and we explain why. We also estimate the up and down contributions to the kinetic energy of correlation.
description: new version, to appear in PRB Rapid Communication
Additional file 1 of Are there non-linear relationships between alcohol consumption and long-term health?: a systematic review of observational studies employing approaches to improve causal inference
Creators: name: Visontay, Rachel
name: Sunderland, Matthew
name: Slade, Tim
name: Wilson, Jack
name: Mewton, Louise
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1.
Notopodops omani Barber & Sailer 1953
Creators: name: Rider, David A.
name: Swanson, Daniel R.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Pentatomidae
Notopodops
Notopodops omani

description: Notopodops omani Barber & Sailer, 1953
 Distribution: United States: TX.
description: Published as part of Rider, David A. & Swanson, Daniel R., 2021, A distributional synopsis of the Pentatomidae (Heteroptera) north of Mexico, including new state and provincial records, pp. 1-69 in Zootaxa 5015 (1) on page 48, DOI: 10.11646/zootaxa.5015.1.1, http://zenodo.org/record/5159085
Real-world cost-effectiveness of insulin degludec in type 1 and type 2 diabetes mellitus from a Swedish 1-year and long-term perspective
Creators: name: Jendle, Johan
name: Ericsson, Åsa
name: Ekman, Bertil
name: Sjöberg, Stefan
name: Gundgaard, Jens
name: Da Rocha Fernandes, João
name: Ann-Charlotte Mårdby
name: Hunt, Barnaby
name: Malkin, Samuel JP
name: Thunander, Maria
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy

description: Background and Aims: The ReFLeCT study demonstrated that switching to insulin degludec from other basal insulins was associated with reductions in glycated hemoglobin and hypoglycemic events in type 1 (T1D) and type 2 diabetes (T2D), and reductions in insulin doses in T1D. The aim of the present analysis was to assess the short- and long-term cost-effectiveness of switching to insulin degludec in Sweden. Methods: Short-term outcomes were evaluated over 1 year in a Microsoft Excel model, while long-term outcomes were projected over patient lifetimes using the IQVIA CORE Diabetes Model. Cohort characteristics and treatment effects were sourced from the ReFLeCT study. Costs (in 2018 Swedish krona [SEK]) encompassed direct medical expenditure and indirect costs from loss of workplace productivity. In the long-term analyses, patients were assumed to receive insulin degludec or continue prior insulin therapy (primarily insulin glargine U100) for 5 years, before all patients intensified to once-daily degludec and mealtime aspart. Results: Switching to insulin degludec was associated with improved quality-adjusted life expectancy of 0.04 and 0.02 quality-adjusted life years (QALYs) over 1 year, and 0.16 and 0.08 QALYs over patient lifetimes, in T1D and T2D. Combined costs in T1D and T2D were estimated to be SEK 1 249 lower and SEK 1 181 higher over the short term, and SEK 157 258 and SEK 2 114 lower over the long term. Benefits were due to lower insulin doses in T1D, reduced rates of hypoglycemia and lower incidences of diabetes-related complications. Insulin degludec was associated with an incremental cost-effectiveness ratio of SEK 64 298 per QALY gained for T2D over 1 year and considered dominant for T1D and T2D in all other comparisons. Conclusions: Insulin degludec was projected to be cost-effective or dominant versus other basal insulins for the treatment of T1D and T2D in Sweden.
Additional file 2 of Time to early initiation of postnatal care service utilization and its predictors among women who gave births in the last 2 years in Ethiopia: a shared frailty model
Creators: name: Debie, Ayal
name: Getayeneh Antehunegn Tesema
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 2. Log rank test for the predictors of PNC services utilizations among mothers who gave birth in the last 2 years, 2016