cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The structural and functional roles of mitochondrial fission adaptors in yeast and humans
Creators: name: Koirala, Sajjan
Publisher: name: University of Utah
Year: 2015
Subjects: Coiled-coil
Dynamics
Fission
Fusion
Membrane
Mitochondria

description: The mitochondrion is an essential organelle in eukaryotic cells. The major functions of mitochondria are ATP production, calcium homeostasis, heme and lipid biosynthesis and apoptosis. Mitochondria form a dynamic tubular spaghetti-like network that fuses, divides and moves within the cell. The molecular events that regulate mitochondrial dynamics are important for various cellular and developmental processes and are linked to cellular dysfunction and disease. This dissertation focuses on the molecular machineries that carry out mitochondrial fission in yeast and human. Mitochondrial fission requires both dynamin-related GTPases (called Dnm1/Drp1 in yeast/human) and membrane adaptors. In yeast, a tail-anchored protein called Fis1 and an adaptor protein called Mdv1 recruit Dnm1 to the membrane. Mdv1 interacts with Dnm1 and stimulates Dnm1 self-assembly. Although Fis1 is conserved in humans, an Mdv1 ortholog is absent. Instead, humans have at least three other membrane anchored proteins (Mff, MiD49, MiD51/MIEF1) whose roles in fission are poorly defined. Studies presented in this thesis address two key issues related to mitochondrial fission. First, experiments in Chapter 2 address how the structure of the yeast mitochondrial adaptor (Mdv1) affects Dnm1 function. A structural study of the Mdv1 central domain shows that this region forms an unusually long antiparallel coiled coil which positions the P-propeller domains of Mdv1 to interact with Dnm1 as it transitions from the cytoplasm to mitochondria. In vivo studies with altered coiled coil domains demonstrates the importance of this domain in Mdv1-Fis1 binding, Dnml mitochondrial recruitment and Dnm1-mediated mitochondrial fission. Second, experiments in Chapter 3 determine whether multiple human adaptors are capable of working independently to elicit Drp1-mediated membrane fission. In vivo studies using the yeast and human adaptors in a minimal yeast system show that Fis1 is dispensable for mitochondrial membrane scission. These studies also demonstrate that Mdv1, Mff, or MiDs can work in parallel with their corresponding DRPs to catalyze membrane fission. Importantly, coassembly of MiD49 protein with Drp1 dramatically decreases the diameter of assembled Drp1 structures. Together, these studies advance our understanding of how adaptors and fission dynamins work together to achieve membrane constriction and fission, and raise important questions for future studies.
Sonnenfleckenzeichnung Nr. 23679.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.06.1971, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1971

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
IoP Project Juno: A reflection of over a decade of equality and diversity work within the UK
Creators: name: Berry, Tracey
Publisher: name: Zenodo
Year: 2022

description: The UK Institute of Physics established Project Juno in 2007 to address the under representation of women in physics. UK universities and now also national research institutes are invited to join the scheme and work towards achieving the three levels of award: supporter, practitioner and champion. The speaker has experience of implementing good practice at a University (over 10 years) and in assessing other Universities (6 years). The talk will reflect on the progress made in the past decade and look towards what Universities and individuals can do now to support and improve equality, diversity and inclusion.
Book Review: יקיר אנגלנדר. הגוף הגברי החרדי-ליטאי בספרות המוסר ובסיפורי הצדיקים
Creators: name: Neriya-Ben Shahar, R.
Publisher: name: Zenodo
Year: 2018

description: Book Review: יקיר אנגלנדר. הגוף הגברי החרדי-ליטאי בספרות המוסר ובסיפורי הצדיקים
Upgrade of the CSC Muon System for the CMS Detector at the HL-LHC
Creators: name: Bonilla, Johan Sebastian
Publisher: name: Zenodo
Year: 2022

description: The Large Hadron Collider (LHC) will be upgraded in several phases to significantly expand its physics program. After the current long shutdown from 2018-2021 (LS2) the accelerator luminosity will be increased to 2 − 3 * 10^34cm−2s−1 exceeding the design value of 1 * 10^34cm−2s−1 allowing the CMS experiment to collect approximately 100 fb−1/year. A subsequent upgrade will increase the luminosity up to 5 * 10^34cm−2s−1. The CMS muon system must be able to sustain a physics program after the LS2 shutdown that maintains sensitivity to electroweak scale physics and for TeV scale searches similar to what was achieved up to now For the Cathode Strip Chamber (CSC) muon detectors. The on chamber front-end readout electronics portion of the CSC electronics upgrade has now been completed. The design of the upgraded CSC electronics will be discussed as well as the status of the commissioning of the upgraded CSC system. In view of the operating conditions at HL-LHC, it is vital to asses the detector performance for high luminosity. Accelerated aging tests are being performed to study the behavior of the CSC detectors under conditions which are nearly an order of magnitude beyond the original design values. The status of this irradiation campaign and results will be presented.
Additional file 3 of Coding transcriptome analyses reveal altered functions underlying immunotolerance of PEG-fused rat sciatic nerve allografts
Creators: name: Smith, Tyler A.
name: Ghergherehchi, Cameron L.
name: Tucker, Haley O.
name: Bittner, George D.
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Fig. S2. (FigS2_Count_Analyses.pdf). Distribution and correlation of normalized read counts among samples. (A) Violin plots showing the distribution of all log2 normalized read counts for each gene transcript in each sample. The median is indicated by a solid horizontal line, and the upper quartile is indicated by a dashed horizontal line. The plots show that the majority of genes in each sample share similar expression profiles and are not differentially expressed. (B) Principle component analysis (PCA) allowing clustering of samples based on variation in expression profiles of all protein coding genes. Samples with similar expression profiles cluster together more closely. (C) Sample-to-sample correlation matrix comparing the gene expression profiles of all coding genes between all individual samples, using normalized read counts. White indicates a Pearson correlation coefficient of <0.6 (lower correlation); black indicates a coefficient of 1 (high correlation).
ATF4 links ER stress with reticulophagy in glioblastoma cells
Creators: name: Zielke, Svenja
name: Kardo, Simon
name: Zein, Laura
name: Mari, Muriel
name: Covarrubias-Pinto, Adriana
name: Kinzler, Maximilian N.
name: Meyer, Nina
name: Stolz, Alexandra
name: Fulda, Simone
name: Reggiori, Fulvio
name: Kögel, Donat
name: van Wijk, Sjoerd
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: Selective degradation of the endoplasmic reticulum (ER; reticulophagy) is a type of autophagy involved in the removal of ER fragments. So far, amino acid starvation as well as ER stress have been described as inducers of reticulophagy, which in turn restores cellular energy levels and ER homeostasis. Here, we explored the autophagy-inducing mechanisms that underlie the autophagic cell death (ACD)-triggering compound loperamide (LOP) in glioblastoma cells. Interestingly, LOP triggers upregulation of the transcription factor ATF4, which is accompanied by the induction of additional ER stress markers. Notably, knockout of ATF4 significantly attenuated LOP-induced autophagy and ACD. Functionally, LOP also specifically induces the engulfment of large ER fragments within autophagosomes and lysosomes as determined by electron and fluorescence microscopy. LOP-induced reticulophagy and cell death are predominantly mediated through the reticulophagy receptor RETREG1/FAM134B and, to a lesser extent, TEX264, confirming that reticulophagy receptors can promote ACD. Strikingly, apart from triggering LOP-induced autophagy and ACD, ATF4 is also required for LOP-induced reticulophagy. These observations highlight a key role for ATF4, RETREG1 and TEX264 in response to LOP-induced ER stress, reticulophagy and ACD, and establish a novel mechanistic link between ER stress and reticulophagy, with possible implications for additional models of drug-induced ER stress. Abbreviations: ACD: autophagic cell death; ATF6: activating transcription factor 6; ATL3: atlastin 3; BafA1: bafilomycin A1; CCPG1: cell cycle progression gene 1; co-IP: co-immunoprecipitation; DDIT3/CHOP: DNA damage inducible transcript 3; ER: endoplasmic reticulum; EIF2A/eIF2α: eukaryotic translation initiation factor 2A; EIF2AK3/PERK: eukaryotic translation initiation factor 2 alpha kinase 3; ERN1/IRE1α: endoplasmic reticulum to nucleus signaling 1; GABARAP: GABA type A receptor-associated protein; GBM: glioblastoma multiforme; HSPA5/BiP: heat shock protein family (Hsp70) member 5; LOP: loperamide; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; RETREG1/FAM134B: reticulophagy regulator 1; RTN3L: reticulon 3 long; SEC62: SEC62 homolog, protein translocation factor; TEX264: testis-expressed 264, reticulophagy receptor; UPR: unfolded protein response.
Sonnenfleckenzeichnung Nr. 24469.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.06.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Amblyoproctus rugosus
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Amblyoproctus
Amblyoproctus rugosus

description: Amblyoproctus rugosus (Erichson, 1847)
Phileurus rugosus Erichson 1847: 96 (Peru - LECTOTYPE)
Distribution. Suriname: MHCN - NEW COUNTRY RECORD (Suriname, Sipaliwini.). French Guiana: Brûlé et al. 2011a: 191; Ponchel 2011: 61; Dupuis 2016b: 110. Other: Erichson 1847: 96 (Peru - as Phileurus rugosus); Arrow 1937b: 91 (Peru); Blackwelder 1944: 259 (Peru); Endrödi 1977c: 41 (Peru - designation LECTOTYPE Phileurus rugosus), 1985a: 707 (Peru); Lachaume 1992: 52 (Peru).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 216, DOI: 10.5281/zenodo.3678492
Interlanguage pragmatics in Russian: the speech act of request in email
Creators: name: Krulatz, Anna M.
Publisher: name: University of Utah
Year: 2012
Subjects: Email
Interlanguage
Nonnative
Politeness
Pragmatics
Request

description: As face-threatening speech acts, requests are of particular interest to second language acquisition scholars. They affect the interlocutors' public self-images, and thus require a careful consideration of the social distance between the interlocutors, their status, and the level of the imposition, factors that are weighed differently in different cultures. Studies have revealed that while use of direct and conventionally indirect strategies to perform requests seems to be a universal property of language, languages differ with respect to the choice of linguistic means employed in these two types of strategies. Even though nonnative speakers' perceptions of politeness in requests correlate with those of native, differences in performance exist. Findings from former studies suggest that second language learners' sociolinguistic competence is not native like. To date, however, most studies on performance of requests have focused on English as a second or foreign language. The present study broadens current research by examining requests written by native and nonnative speakers of Russian. The second focus of this study is electronic communication. As a relatively new means of communication, the sociolinguistic dynamics of email is not adequately understood. However, its use for daily communication is increasing in all domains of life, including communication between university students and professors. Former research suggests that inappropriately formulated emails can affect how professors perceive students. As with requests in general, however, most studies to date on email have been iv conducted on English data. Using the Discourse Completion Task (DCT) as the elicitation method, the present study examined electronic messages written by native and nonnative speakers of Russian. The messages were rated by three native speakers on three scales: clarity, social appropriateness, and politeness. One-way ANOVA revealed significant differences between the groups on all three scales. In addition, head acts, alerters, supportive moves, and internal modifications were analyzed using the Cross- Cultural Speech Act Realization Project (CCSARP) coding manual. The strategy analysis revealed interesting similarities and differences between the groups. The study concluded that while Russian learners have approximated native sociolinguistic competence on some levels, significant gaps between native and nonnative formulation of electronic requests remain.
Additional file 7 of Coding transcriptome analyses reveal altered functions underlying immunotolerance of PEG-fused rat sciatic nerve allografts
Creators: name: Smith, Tyler A.
name: Ghergherehchi, Cameron L.
name: Tucker, Haley O.
name: Bittner, George D.
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 7: Fig. S3. (FigS3_BiNGO_Diagram_Clusters.pdf). Enlarged versions of the BiNGO cluster diagrams displayed in Figs. 3A-D, in which each cluster can be zoomed-in on with clarity to view all associated GO annotations and their interrelations. (Page 1) Cluster 1 (enriched in PEG); (Page 2) Cluster 2 (enriched in PEG and Unop); (Page 3) Cluster 3 (enriched in Unop); (Page 4) Cluster 4 (enriched in NC).
"Some Outlooks Are Not Our Own, But If I Happen To See One I'Ll Look At It From Time To Time": Self-Definition Of Haredi (Ultra-Orthodox) Women According To Patterns Of Exposure To The Haredi Press
Creators: name: Neriya-Ben Shahar, R.
Publisher: name: Zenodo
Year: 2018

description: מאמר זה עוסק בדפוסי הצריכה של עיתונות חרדית בקרב נשים חרדיות. הטענה המרכזית המובאת במאמר היא שעיתונים חרדיים ממלאים לא רק את הפונקציות התקשורתיות של סיקור, תיאום, המשכיות, בידור וגיוס,2 אלא יש להם תפקיד חשוב ומשמעותי של הגדרת זהות. בחירת העיתון, קנייתו, קריאתו, העברתו לקוראים נוספים והשיח עליו משמשים עבור נשים חרדיות כלי להגדרה עצמית־קבוצתית מורכבת, הכוללת את החברה החרדית, את הבית החרדי, את המשפחה החרדית ואת

האישה שקוראת את העיתון.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 01.01.1974, erstellt am Kandilli Observatorium Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Kandilli Rasathanesi, Çengelköy (Istanbul). Später wurden ergänzende Angaben aufgrund weiterer Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Instrument: Refraktor Teleskop (Öffnung 200 mm, f = 3070 mm, projiziertes Sonnenbild D = 25 cm).
Instrumentennachweis gemäss Kandilli Observatory Istanbul, Report from Solar Institute, in: Solar Physics, 1968, Vol. 3, Issue 3, pp.491-492, DOI: https://doi.org/10.1007/BF00171622
Sonnenfleckenzeichnung Nr. 24462.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.06.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
"Please Lengthen Your Skirts For The Sake Of The Sanctity Of Our People And The Sanctity Of Our Daughters": The Modesty Discourse In The Women'S Sections Of The Ultra-Orthodox Press, 1960-1989.
Creators: name: Neriya-Ben Shahar, R.
Publisher: name: Zenodo
Year: 2018

description: מאמר זה עוסק בטקסטים בענייני צניעות שנכתבו במדורי הנשים בעיתונות החרדית המפלגתית מתחילת שנות השישים ועד סוף שנות השמונים, ומטרתו להבין כיצד התקשורת היא כלי לסוציאליזציה בנושא השליטה על הגוף הנשי בחברה מסורתית. השאלה הנגזרת ממטרה זו והניצבת בבסיסו של המחקר היא כיצד סוגיית הצניעות משתקפת במדורים המיועדים לנשים שהתפרסמו בעיתונות החרדית המפלגתית בשנים 1960‐1989. כדי לענות על השאלה נבחן קורפוס רחב שכלל את כ ל הטקסטים שהתפרסמו בשנים אלו במדורי הנשים בעיתונים המודיע ויתד נאמן, ומהם נבחרו אלו

שעסקו בנושא הצניעות.
An experimental investigation of thermoacoustic lasers operating in audible frequency range
Creators: name: Kolhe, Sanket Anil
Publisher: name: University of Utah
Year: 2013

description: Thermoacoustic lasers convert heat from a high-temperature heat source into acoustic power while rejecting waste heat to a low temperature sink. The working fluids involved can be air or noble gases which are nontoxic and environmentally benign. Simple in construction due to absence of moving parts, thermoacoustic lasers can be employed to achieve generation of electricity at individual homes, water-heating for domestic purposes, and to facilitate space heating and cooling. The possibility of utilizing waste heat or solar energy to run thermoacoustic devices makes them technically promising and economically viable to generate large quantities of acoustic energy. The research presented in this thesis deals with the effects of geometric parameters (stack position, stack length, tube length) associated with a thermoacoustic laser on the output sound wave. The effects of varying input power on acoustic output were also studied. Based on the experiments, optimum operating conditions were identified and qualitative and/or quantitative explanations were provided to justify our observations. It was observed that the maximum sound pressure level was generated for the laser with the stack positioned at a distance of quarter lengths of a resonator from the closed end. Higher sound pressure levels were recorded for the laser with longer stack lengths and longer resonator lengths. Efforts were also made to develop high-frequency thermoacoustic lasers.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.02.1974, erstellt am Sonnenobservatorium Kanzelhöhe, Kärnten
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage im Sonnenobservatorium Kanzelhöhe in Sattendorf, Österreich. Instrument: Heliostat mit Refraktor Eigenbau (Öffnung 110mm, f = 1650mm, projiziertes Sonnenbild D = 25cm)
Simulation studies for the ATLAS track counting luminosity measurement
Creators: name: Ripellino, Giulia
Publisher: name: Zenodo
Year: 2022

description: A precise measurement of the luminosity is a key component of the ATLAS physics programme. ATLAS uses several detectors and algorithms to determine the luminosity. The absolute calibration of these algorithms is carried out in LHC runs with special beam conditions at low luminosity. The track counting luminosity measurement is used to determine the calibration transfer from the low-luminosity regime to the high-luminosity conditions typical of standard physics data taking, and to monitor the long term stability of the default luminosity method. The track counting method works by counting the number of reconstructed tracks from charged particles inside the Inner Detector. The average number of charged particles in randomly-triggered bunch crossings is proportional to the average number of inelastic collisions per bunch crossing and can therefore be used to compute the luminosity. This poster presents simulation studies for the ATLAS track counting luminosity measurement. A toy simulation model is used to study the underlying distribution of the number of tracks and to illustrate the linearity between the average number of tracks and the luminosity. Full ATLAS MC simulation is used to asses effects related to the reconstruction of the tracks and their effect on the linearity.
Additional file 3 of Viral ecogenomics across the Porifera
Creators: name: Pascelli, Cecília
name: Laffy, Patrick W.
name: Botté, Emmanuelle
name: Kupresanin, Marija
name: Rattei, Thomas
name: Lurgi, Miguel
name: Ravasi, Timothy
name: Webster, Nicole S.
Publisher: name: figshare
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Zoology

description: Additional file 3. This file includes: Figure S1. Non-metric multidimensional scaling plot based on Bray-Curtis similarity of Swiss-Prot functional keyword for predicted genes. Figure S2. Heatmap of viral functions that were significantly different between HMA and LMA sponges. Figure S3. Heatmap of viral functions that were significantly different between sponges with and without photosymbionts. Table S1. Pairwise PERMANOVA results of predicted viral genes associated with fifteen sponge species from the Great Barrier Reef and the Red Sea based on viral RefSeq taxonomic assignments (genus level). Table S2. Average similarity (%) between and within sponge species from the Great Barrier Reef based on viral RefSeq gene taxonomic assignments (genus level). Table S3. Average similarity (%) between and within sponge species from the Red Sea based on Swiss-Prot keyword abundance data. Table S4. Pairwise PERMANOVA results of predicted viral genes associated with fifteen sponge species from the Great Barrier Reef and the Red Sea. Table S5. Average similarity (%) between and within sponge species from the Great Barrier Reef based Swiss-Prot keyword abundance data. Table S6. Average similarity (%) between and within sponge species from the Red Sea based on Swiss-Prot keyword abundance data.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.02.1974, erstellt als weitere, zusätzlich ausgeführte Tagesaufnahme von Fritz Riesen bzw. vermutlich dank auswärtiger Beobachtungen eröffnet
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung vermutlich unter Einbezug der Auswertung auswärtiger Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen direkt auf dem Vordruck, unter Umständen teilweise mit dem Zeiss Coudé-Refraktor (150/2250 mm) der Eidgenössischen Sternwarte Zürich
Sonnenfleckenzeichnung Nr. 24446.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 25.05.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
An inverted CAV1 (caveolin 1) topology defines novel autophagy-dependent exosome secretion from prostate cancer cells
Creators: name: Ariotti, Nicholas
name: Wu, Yeping
name: Okano, Satomi
name: Gambin, Yann
name: Follett, Jordan
name: Rae, James
name: Ferguson, Charles
name: Teasdale, Rohan D.
name: Alexandrov, Kirill
name: Meunier, Frederic A.
name: Hill, Michelle M.
name: Parton, Robert G.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: CAV1 (caveolin 1) expression and secretion is associated with prostate cancer (PCa) disease progression, but the mechanisms underpinning CAV1 release remain poorly understood. Numerous studies have shown CAV1 can be secreted within exosome-like vesicles, but antibody-mediated neutralization can mitigate PCa progression; this is suggestive of an inverted (non-exosomal) CAV1 topology. Here we show that CAV1 can be secreted from specific PCa types in an inverted vesicle-associated form consistent with the features of bioactive CAV1 secretion. Characterization of the isolated vesicles by electron microscopy, single-molecule fluorescence microscopy and proteomics reveals they represent a novel class of exosomes ~40 nm in diameter containing ~50-60 copies of CAV1 and, strikingly, are released via a non-canonical secretory macroautophagy/autophagy pathway. This study provides novel insights into a mechanism whereby CAV1 translocates from a normal plasma membrane distribution to an inverted secreted form implicated in PCa disease progression. Abbreviations: 3-MA: 3-methyladenine; APEX: a modified soybean ascorbate peroxidase; ATG5: autophagy related 5; ATG9A: autophagy related 9A; ATG12: autophagy related 12; BHK: baby hamster kidney; C-exosomes: caveolin-exosomes; CAMKK2/CAMKKβ: calckum/calmodulin dependent protein kinase kinase 2; CAV1: caveolin 1; DAB: 3,3′-diaminobenzidine; DAPK: death associated protein kinase; EEA1: early endosome antigen 1; EM: electron microscopy; FCS: fluorescence correlation spectroscopy; GBP: GFP/YFP-binding peptide; GFP: green fluorescent protein; GOLGA2: golgin A2; ILVs: intralumenal vesicles; LC3: microtubule-associated protein 1 light chain 3; MBP: maltose binding protein; MTORC1: mechanistic target of rapamycin kinase complex 1; MVBs: multivesicular bodies; PBS: phosphate-buffered saline; PCa: prostate cancer; PI3K: phosphoinositide 3-kinase; PM: plasma membrane; SFM: serum-free medium; TSG101: tumor susceptibility 101; WCL: whole cell lysates; WT: wild type; YFP: yellow fluorescent protein; βoG: β-octylglucoside
Amblyoproctus squamosus Dechambre 2008
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Amblyoproctus
Amblyoproctus squamosus

description: Amblyoproctus squamosus Dechambre, 2008
Amblyoproctus squamosus Dechambre 2008a: 4 (French Guiana)
Distribution. French Guiana: Dechambre 2008a: 4; Ponchel 2011: 61; Dupuis 2016b: 110.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 216, DOI: 10.5281/zenodo.3678492
CMS Drift Tube (DT) upgrade at High-Luminosity LHC
Creators: name: Kiani, Muhammad Bilal
Publisher: name: Zenodo
Year: 2022

description: The High-Luminosity Large Hadron Collider (HL-LHC) project aims to boost the performance of the LHC in order to increase the potential for discoveries for LHC Run-4 and onwards. The upgrade aims at increasing the instantaneous luminosity of the machine. In order to cope with the expected increase of both radiation and rates, the electronics that host the first level of readout and trigger electronics of the Drift Chambers in CMS must be replaced with the new On-Board electronics for DT (OBDT). The time digitization (TDC) data will be streamed directly to the new backend electronics hosted in the service cavern, where event building and trigger primitive (TP) generation will be performed using the latest commercial FPGAs exploiting the ultimate DT cell resolution. In order to develop and test Phase-2 architecture, a parallel readout of Phase-2 and legacy electronics was set up through front-end splitting on a full DT sector in one external wheel. A series of tests aiming to optimize installation in LS3 were performed. In this report, the motivation for such an upgrade will be highlighted, and the status of the DT slice-test operation, as well as its performance assessed with cosmic-ray events, will be presented.
Changes in Mining induced seismicity before and after the Crandall Canyon Mine collapse
Creators: name: Kubacki, Tex Mitchel
Publisher: name: University of Utah
Year: 2014
Subjects: Collapse
Crandall Canyon
Detection
Earthquake
Seismology

description: On August 6, 2007, the Crandall Canyon Mine in central Utah experienced a major collapse that was recorded as an Mw 4.1 seismic event. Application of waveform cross-correlation detection techniques to data recorded at permanent seismic stations located within ~30 km of the mine has resulted in the discovery of 1,494 previously unknown microseismic events related to the collapse. These events occurred between July 26, 2007, and August 19, 2007, and were detected with a magnitude threshold of completeness of 0.0, about 1.6 magnitude units smaller than the threshold associated with conventional techniques. Relative locations for the events were determined using a double-difference approach that incorporated absolute and differential arrival times. Absolute locations were determined using ground-truth reported in mine logbooks. Lineations apparent in the newly detected events have strikes similar to those of known vertical joints in the mine region, which may have played a role in the collapse. Prior to the collapse, seismicity occurred mostly in close proximity to active mining, though several distinct seismogenic hotspots within the mine were also apparent. In the 48 hours before the collapse, changes in b-value and event locations were observed. The collapse appears to have occurred when the migrating seismicity associated with direct mining activity intersected one of the areas identified as a seismic hotspot. Following the collapse, b-values decreased and seismicity clustered farther to the east.
Sonnenfleckenzeichnung Nr. 24380.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.02.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.02.1974, erstellt am Kandilli Observatorium Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Kandilli Rasathanesi, Çengelköy (Istanbul). Später wurden ergänzende Angaben aufgrund weiterer Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Instrument: Refraktor Teleskop (Öffnung 200 mm, f = 3070 mm, projiziertes Sonnenbild D = 25 cm).
Instrumentennachweis gemäss Kandilli Observatory Istanbul, Report from Solar Institute, in: Solar Physics, 1968, Vol. 3, Issue 3, pp.491-492, DOI: https://doi.org/10.1007/BF00171622
To Browse, Or Not To Browse? Third Person Effect Among Ultra-Orthodox Jewish Women, In Regards To The Perceived Danger Of The Internet
Creators: name: Neriya-Ben Shahar, R. & Lev-On A.
Publisher: name: Zenodo
Year: 2018

description: The study looks at Jewish ultra-Orthodox women who use modern technologies, for purposes that are illegitimate in their community. Subjects’ perceived impacts of the Internet on self and others are analyzed, demonstrating a "third-person effect" in regards to the perceived dangers originating from the Internet. The correlations and possible implications of the "third-person effect" are discussed.
Amblyoproctus torulosus Kolbe 1910
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Amblyoproctus
Amblyoproctus torulosus

description: Amblyoproctus torulosus Kolbe, 1910
Amblyoproctus torulosus Kolbe 1910: 348 (Colombia - LECTOTYPE)
Distribution. Suriname: MHCN - NEW COUNTRY RECORD (Suriname, Sipaliwini.). French Guiana: Duranton 2011: 24; Ponchel 2011: 61; Dupuis 2016b: 110. Brazil (NA): Ratcliffe 1988: 45 (NA); Lachaume 1992: 51. Venezuela: Endrödi 1977c: 39, 1985a: 706; Ratcliffe 1988: 45; Lachaume 1992: 51. Other: Kolbe 1910: 348 (Colombia); Arrow 1937b: 91 (Colombia); Blackwelder 1944: 259 (Colombia); Endrödi 1977c: 39 (Colombia - designation LECTOTYPE Amblyoproctus torulosus, Mexico), 1985a: 706 (Colombia); Ratcliffe 1988: 45 (Colombia); Lachaume 1992: 51 (Colombia).
Note. Endrödi (1977c: 39) records Amblyoproctus torulosus for Mexico, but this record is not repeated in Endrödi (1985a). Ratcliffe et al. (2013) do not mention the genus Amblyoproctus for Belize, Guatemala or Mexico. The inclusion of Mexico in the distribution of this species in Endrödi (1977c) is likely caused by a mislabeled specimen or some other error.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 216, DOI: 10.5281/zenodo.3678492
ATF4 links ER stress with reticulophagy in glioblastoma cells
Creators: name: Zielke, Svenja
name: Kardo, Simon
name: Zein, Laura
name: Mari, Muriel
name: Covarrubias-Pinto, Adriana
name: Kinzler, Maximilian N.
name: Meyer, Nina
name: Stolz, Alexandra
name: Fulda, Simone
name: Reggiori, Fulvio
name: Kögel, Donat
name: van Wijk, Sjoerd J. L.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: Selective degradation of the endoplasmic reticulum (ER; reticulophagy) is a type of autophagy involved in the removal of ER fragments. So far, amino acid starvation as well as ER stress have been described as inducers of reticulophagy, which in turn restores cellular energy levels and ER homeostasis. Here, we explored the autophagy-inducing mechanisms that underlie the autophagic cell death (ACD)-triggering compound loperamide (LOP) in glioblastoma cells. Interestingly, LOP triggers upregulation of the transcription factor ATF4, which is accompanied by the induction of additional ER stress markers. Notably, knockout of ATF4 significantly attenuated LOP-induced autophagy and ACD. Functionally, LOP also specifically induces the engulfment of large ER fragments within autophagosomes and lysosomes as determined by electron and fluorescence microscopy. LOP-induced reticulophagy and cell death are predominantly mediated through the reticulophagy receptor RETREG1/FAM134B and, to a lesser extent, TEX264, confirming that reticulophagy receptors can promote ACD. Strikingly, apart from triggering LOP-induced autophagy and ACD, ATF4 is also required for LOP-induced reticulophagy. These observations highlight a key role for ATF4, RETREG1 and TEX264 in response to LOP-induced ER stress, reticulophagy and ACD, and establish a novel mechanistic link between ER stress and reticulophagy, with possible implications for additional models of drug-induced ER stress. Abbreviations: ACD: autophagic cell death; ATF6: activating transcription factor 6; ATL3: atlastin 3; BafA1: bafilomycin A1; CCPG1: cell cycle progression gene 1; co-IP: co-immunoprecipitation; DDIT3/CHOP: DNA damage inducible transcript 3; ER: endoplasmic reticulum; EIF2A/eIF2α: eukaryotic translation initiation factor 2A; EIF2AK3/PERK: eukaryotic translation initiation factor 2 alpha kinase 3; ERN1/IRE1α: endoplasmic reticulum to nucleus signaling 1; GABARAP: GABA type A receptor-associated protein; GBM: glioblastoma multiforme; HSPA5/BiP: heat shock protein family (Hsp70) member 5; LOP: loperamide; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; RETREG1/FAM134B: reticulophagy regulator 1; RTN3L: reticulon 3 long; SEC62: SEC62 homolog, protein translocation factor; TEX264: testis-expressed 264, reticulophagy receptor; UPR: unfolded protein response.
Architecture that creates community: multi-family housing
Creators: name: Kowalczyk, Alina J
Publisher: name: University of Utah
Year: 2012
Subjects: Urban neighborhoods

description: Environmental urbanism calls for a shift in attitude and our manner of moving. This strategy is a factor in both the quality of life and the economic vitality of urban areas. Inner-city life is to the reduction of travel distance between home, workplace and services, and to encouraging a balance between motor vehicles, bicycles and pedestrians.
Precision Timing with the CMS MIP Timing Detector for HL-LHC
Creators: name: Cardwell, Bryan
Publisher: name: Zenodo
Year: 2022

description: The Compact Muon Solenoid (CMS) detector at the CERN Large Hadron Collider (LHC) is undergoing an extensive Phase II upgrade program to prepare for the challenging conditions of the High-Luminosity LHC (HL-LHC). A new timing detector in CMS will measure minimum ionizing particles (MIPs) with a time resolution of 30-40 ps for MIP signals at a rate of 2.5 Mhit/s per channel at the beginning of HL-LHC operation. The precision time information from this MIP Timing Detector (MTD) will reduce the effects of the high levels of pileup expected at the HL-LHC, bringing new capabilities to the CMS detector. The MTD will be composed of an Endcap Timing Layer (ETL), instrumented with Low-Gain Avalanche Detectors, as well as a Barrel Timing Layer (BTL) based on LYSO:Ce crystals coupled to SiPMs. In this talk we will present overview of the MTD, focusing on recent prototyping results and R&D studies targeting enhanced timing performance and radiation tolerance.
Sonnenfleckenzeichnung Nr. 24414.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.04.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.05.1974, als Blatt eröffnet dank auswärtiger Beobachtungen, ausgewertet in Zürich
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung bzw. Auswertung aufgrund auswärtiger Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen direkt auf dem Vordruck, erstellt durch Mitarbeitende der Eidgenössischen Sternwarte Zürich
Sonnenfleckenzeichnung Nr. 24465.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 17.06.1974, erstellt von Johann Dürst
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Additional file 1 of Crystalline and Electrical Property Improvement of Filtrated, Exfoliated Graphite Sheets by an In-Plane Current and Heating Treatment
Creators: name: Matsumoto, Naoyuki
name: Oshima, Azusa
name: Yumura, Motoo
name: Hata, Kenji
name: Futaba, Don N.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Additional file 1:. Supplemental Fig. 1 Characterizations of exfoliated graphite dispersion and sheet. (a) AFM image, and (b) thickness and size histogram of exfoliated graphite dispersion, and (c) XPS spectra, and (d) SEM image of exfoliated graphite sheet. Supplemental Fig.2 Equipment diagram of Heat and current process for filtrated, exfoliated graphite sheets. Supplemental Fig. 3 Relationship between the electrical conductivity of exfoliated graphite sheet and (b) treatment time and (c) treatment temperature.
Long-term vegetation, climate, and fire history in the Eastern Uinta Mountains, Utah, U.S.A.
Creators: name: Koll, Rebecca Ann
Publisher: name: University of Utah
Year: 2012

description: A 2.13 meter-long sediment core from Reader Fen Basin (3205m asl) in the eastern Uinta Mountains provides a 10,250-year-long cal yr BP record of vegetation change and fire history. Few studies have explored the long-term vegetation and disturbance history from the Uinta Mountains. As a result, significant gaps remain in understanding historical processes affecting ecosystem dynamics from this region. The vegetation history at Reader Fen Basin suggests subalpine forest species (e.g., Picea engelmannii and Pinus contorta) expanded in the Uinta Mountains soon after glaciers retreated by 9000 cal yr BP. The charcoal-based fire history reconstruction from Reader Fen Basin suggests fires occurred on average every 470 years during the last 10,000 years. Three major shifts in vegetation composition occurred during the Holocene: 1) the displacement of grass and alpine herbaceous communities as arboreal species colonized the watershed, between 10,250 and 9000 cal yr BP, 2) the replacement of Picea engelmannii by the expansion of Pinus contorta forests into the watershed during the middle Holocene, beginning at 9000 cal yr BP when fire became more prominent in the ecosystem, and 3) a reduction of Cyperaceae as grasses began to dominate the fen during the last 3200 cal yr BP. These three major shifts in vegetation composition are largely the result of changing climate and fire frequency. Understanding the frequency and magnitude of past disturbances is necessary for understanding the catalyst of vegetation change for making informed management decisions on present and future ecological change in the Uinta Mountains.
Sonnenfleckenzeichnung Nr. 24435.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.05.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen