cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
ParrBomb Basics Manual V1
Creators: name: Fox, Austin
Publisher: name: figshare
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: Geochemistry
subject: FOS: Earth and related environmental sciences
subject: Mineralogy

description: This procedure descibes the Basics of using a Parr Bomb. It has yet to be used in our lab...
Electronic Supplementary Material Appendices from A cluster of N-bubbles driven along a channel at high imposed driving pressure: film orientations and bubble pressures
Creators: name: Grassia, P.
name: Torres-Ulloa, C.
name: Hernández-Montelongo, J.
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 401299
subject: Fluid mechanics and thermal engineering not elsewhere classified
classificationCode: 490199
subject: Applied mathematics not elsewhere classified
classificationCode: 499999
subject: Other mathematical sciences not elsewhere classified

description: These supplementary sections provide appendices and also tabulated raw data
Bruker D8 Discover Alignment Procedure Manual
Creators: name: Fox, Austin
Publisher: name: figshare
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Crystallography
subject: Geochemistry
subject: FOS: Earth and related environmental sciences
subject: Mineralogy
subject: Mechanical Engineering
subject: FOS: Mechanical engineering

description: This file discribes the alignment of the Bruker D8 Discover at Oregon State University. XRD Alignment Proceedure XRD Alignment Manual
Draft Supplementary on Bubble Areas from A cluster of N-bubbles driven along a channel at high imposed driving pressure: Film orientations and bubble pressures
Creators: name: Grassia, Paul
name: Torres-Ulloa, Carlos
name: Hernandez-Montelongo, Jacobo
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 490199
subject: Applied mathematics not elsewhere classified

description: Reviewer and board member asked to see a future draft supplementary material on bubble areas
Bruker D8 Discover Basic Measurement Manual
Creators: name: Fox, Austin
Publisher: name: figshare
Year: 2015
Subjects: subject: Crystallography
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Geochemistry
subject: FOS: Earth and related environmental sciences
subject: Mineralogy
subject: Mechanical Engineering
subject: FOS: Mechanical engineering

description: Bruker D8 Discover Basic Measurement Manual XRD Manual XRD Procedure
Electronic Supplementary Material Appendices from A cluster of N-bubbles driven along a channel at high imposed driving pressure: Film orientations and bubble pressures
Creators: name: Grassia, Paul
name: Torres-Ulloa, Carlos
name: Hernandez-Montelongo, Jacobo
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 490199
subject: Applied mathematics not elsewhere classified

description: These supplementary sections provide appendices and also tabulated raw data
Draft Manuscript on Bubble Areas from A cluster of N-bubbles driven along a channel at high imposed driving pressure: film orientations and bubble pressures
Creators: name: Grassia, P.
name: Torres-Ulloa, C.
name: Hernández-Montelongo, J.
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 401299
subject: Fluid mechanics and thermal engineering not elsewhere classified
classificationCode: 490199
subject: Applied mathematics not elsewhere classified
classificationCode: 499999
subject: Other mathematical sciences not elsewhere classified

description: Reviewer and board member asked to see a future draft manuscript on bubble areas
ВОЯГА ЕТМАГАНЛАР ТОМОНИДАН СОДИР ЭТИЛГАН ЖИНОЯТЛАРГА НИСБАТАН БЕЛГИЛАНАДИГАН ЖАВОБГАРЛИКНИНГ ЎЗИГА ХОС ЖИҲАТЛАРИ
Creators: name: Мирсалихова, Гузал
Publisher: name: Zenodo
Year: 2024

description: Мақолада, вояга етмаганлар жиноятчилигининг турлари ва унинг ўзига хос жиҳатлари, шунингдек ушбу жиноятларга қарши курашиш бўйича қонунчилик нормаларини такомиллаштириш ҳамда самарадорлигини ошириш юзасидан таклиф ва тавсиялар берилган.
Bruker Eva Bascis
Creators: name: Fox, Austin
Publisher: name: figshare
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Crystallography
subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: Geochemistry
subject: FOS: Earth and related environmental sciences
subject: Mineralogy

description: This manual discribes how to use Eva for basic data analysis. It includes up to peak searching and matching.
Draft Manuscript on Bubble Areas from A cluster of N-bubbles driven along a channel at high imposed driving pressure: Film orientations and bubble pressures
Creators: name: Grassia, Paul
name: Torres-Ulloa, Carlos
name: Hernandez-Montelongo, Jacobo
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 490199
subject: Applied mathematics not elsewhere classified

description: Reviewer and board member asked to see a future draft manuscript on bubble areas
ParrBomb Basics V1
Creators: name: Fox, Austin
Publisher: name: figshare
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: Geochemistry
subject: FOS: Earth and related environmental sciences
subject: Mineralogy

description: This procedure descibes the Basics of using a Parr Bomb. It has yet to be used in our lab...
St. Anthony Falls Laboratory Assessment of Data Practices and Needs
Creators: name: Hsu, Leslie
name: Nguyen, Charles
Publisher: name: figshare
Year: 2015
Subjects: subject: Geophysics
subject: FOS: Earth and related environmental sciences
subject: Geology
subject: Hydrology

description: A report on the data practices and needs of selected Earth science and engineering investigators at the St. Anthony Falls Laboratory, University of Minnesota. Conducted in September 2012.
Non-Abelian quasi-particles in electronic systems
Creators: name: Borcherding, Daniel
Publisher: name: Hannover : Institutionelles Repositorium der Leibniz Universität Hannover
Year: 2018
Subjects: subject: anyons
subject: WZNW models
subject: anyon condensation
subject: Bethe-Ansatz
subject: Anyonen
subject: WZNW-Modelle
subject: Anyonen-Kondensation
subject: Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik

description: Ever since the proposal of Kitaev for decoherence-free quantum computing based on non-Abelian anyons physical realizations of these exotic particles have been investigated extensively. Starting from one-dimensional models of interacting fermions with different symmetries the emergence and condensation of $\mathfrak{su}(2)_{N_f}$, $\mathfrak{su}(3)_{N_f}$ and $\mathfrak{so}(5)_{N_f}$ anyons is studied in the framework of integrable perturbed WZNW models. For sufficiently small temperatures and fields non-Abelian anyons residing on massive solitonic excitations are identified by their quantum dimension. By tuning the external fields the density of anyons can be increased continuously to study the effect of interactions between them. For each model the conformal field theories describing the various collective states of the interacting anyons are determined and a phase diagram for the anyonic modes is proposed.
description: Seit dem Vorschlag von Kitaev zu dekohärenzfreien Quantencomputern basierend auf nicht-abelschen Anyonen wurden physikalische Realisierungen dieser exotischen Teilchen ausgiebig erforscht. Ausgehend von eindimensionalen Modellen für wechselwirkende Fermionen mit unterschiedlichen Symmetrien wird die Entstehung und Kondensation von $\mathfrak{su}(2)_{N_f}$, $\mathfrak{su}(3)_{N_f}$ und $\mathfrak{so}(5)_{N_f}$-Anyonen im Rahmen von integrablen gestörten WZNW-Modellen untersucht. Für hinreichend kleine Temperaturen und Felder werden nicht-abelsche Anyonen, die an massive solitonische Anregungen gebunden sind, über ihre Quantendimension identifiziert. Durch Einstellen der externen Felder kann die Dichte der Anyonen erhöht werden, um den Effekt von Wechselwirkungen zwischen ihnen zu untersuchen. Für jedes Modell werden die konformen Feldtheorien, welche die verschiedenen kollektiven Zustände der wechselwirkenden Anyonen beschreiben, bestimmt und ein Phasendiagramm für die anyonischen Moden vorgeschlagen.
Global Ready To Drink Cocktails Market Study
Creators: name: Pankaj24
Publisher: name: Zenodo
Year: 2022
Subjects: Ready To Drink Cocktails Market

description: Global Ready To Drink Cocktails Market segmented by Alcohol base (Beer based - (Ale, Lager, Hybrid), Malt based, Wine based - (Sparkling, Fortified, Others), Distilled Spirits- (Rum, Whiskey, Vodka, Others)) & by Region - Forecast and Analysis 2020-2027 Market Insights The global ready to drink cocktails market was valued at USD 4,510.51 Million in 2020, and it is expected to reach a value of USD 14,580.3 Million by 2027, at a CAGR of 16.20% over the forecast period (2020 - 2027). Ready to drink cocktails is a flavored carbonated alcoholic beverage that contains low calories and carbohydrates in comparison to other alcoholic beverages. Rising demand for low alcohol content, low calories, and gluten-free beverages is driving the growth of the market. Additionally, increased disposable income and overall spending on alcoholic beverages are also contributing to market growth in the given forecast period. Ready to drink cocktails has gained enormous popularity due to effective social media marketing that has sold Ready to drink cocktailss as a “healthier” alcohol choice. Ready to drink cocktails's growth is also due to numerous manufacturers entering the market and offering a large variety of products and multiple product launches. For instance, in May 2020 Kopparberg, a Swedish manufacturer launched a range of Ready to drink cocktails drinks in the U.K.
description: NA
Die Sedimente am Rand des Oberen Theodul-Gletschers bei Zermatt. (Zur Deutung quartärer Sedimente und Formen IX)
Creators: name: German, Rüdiger
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1972

description: Jahreshefte der Gesellschaft für Naturkunde in Württemberg
description: Bd. 127, 1972
Art, maths, electronics and micros: The late work of Stan Ostoja-Kotkowski
Creators: name: Swalwell, Melanie
name: Garda, Maria
Publisher: name: Swinburne
Year: 2024

description: To date, most work on computers in art has focused on the Algorists (1960s–) and on later cyber arts (1990s–). The use of microcomputers is an underexplored area, with the 1980s constituting a particular gap in the knowledge. This article considers the case of Polish-Australian artist, Stan Ostoja-Kotkowski (b. 1922, d. 1994), who after early exposure to computers at the Bell Labs (1967), returned to microcomputers late in his life. He was not a programmer yet used micros in his practice from the early 1980s, first a BBC in his BP Christmas Star commission, and later a 32-bit Archimedes. This he used from 1989 until his death to produce still images with a fractal generator and the ‘paintbox’ program, “Photodesk”. Drawing on archival research and interviews, we focus on three examples of how Ostoja deployed his micro, highlighting the convergence of art, maths, electronics, and a ‘hands-on’ tinkering ethic in his practice. We argue that when considering the history of creative microcomputing, it is imperative to go beyond the field of art itself. In this case, electronics and the hobbyist computing scenes provide crucial contexts
Profile aus dem Oberen Muschelkalk im Gebiet Lauffen a. N. - Besigheim (Baden-Württemberg)
Creators: name: Gwinner, Manfred P.
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1972

description: Jahreshefte der Gesellschaft für Naturkunde in Württemberg
description: Bd. 127, 1972
Zur Geologie der Waldenburger Berge zwischen Brettach und Bibers
Creators: name: Gwinner, Manfred P.
name: Neamat-Allah, Fathy
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1972

description: Jahreshefte der Gesellschaft für Naturkunde in Württemberg
description: Bd. 127, 1972
ICT4D for smart governance of rural development
Creators: name: Kimm, Geoff
name: Doloi, Hemanta
Publisher: name: Swinburne
Year: 2024

description: Aligned with smart villages, smart governance can identify and address gaps between services provided to communities, the needs of communities, and support for self-reliant interaction within communities. This paper presents ongoing work on a survey-based information communication technology for development (ICT4D) model for smart governance and an associated proof-of-concept software tool, with an emphasis on an Assamese context.
The 2017-18 small business tax concessions in a digital world: small wine makers and grape growers
Creators: name: Kenny, Paul
name: Devos, Ken
name: Villios, Sylvia
Publisher: name: Swinburne
Year: 2024

description: Whilst the Commonwealth government acknowledges the challenges to small business with the digital economy in its Small Business Digital Taskforce (2018) and the Board of Taxation (2018) review of small business tax concessions, these reviews remain a work in progress and they do not have a particular focus on the wine makers and grape growers. This paper contributes to the literature by examining the Commonwealth income tax, goods and services tax (GST), fringe benefits tax (FBT) and wine equalisation tax (WET) concessions provided to small wine makers and grape growers that help them succeed in the digital economy. Despite the high compliance taxation. costs for small business generally and the extra burden on the wine industry with the WET compliance, the paper finds very little help by way of tax concessions for small wine and grape businesses. This provides a stark contrast to the generous tax breaks of billions of dollars provided to large businesses, particularly largely foreign owned companies.
Die Wanzenfauna des mittleren Neckartales und der angrenzenden Albhochfläche (Landkreise Nürtingen, Reutlingen, Tübingen)
Creators: name: Rieger, Christian
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1972

description: Jahreshefte der Gesellschaft für Naturkunde in Württemberg
description: Bd. 127, 1972
GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation
Creators: name: Penas, Clara
name: Jitendra K Mishra
name: Wood, Spencer D
name: Schürer, Stephan C
name: Roush, William R
name: Ayad, Nagi G
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Ubiquitin mediated proteolysis is required for transition from one cell cycle phase to another. For instance, the mitosis inhibitor Wee1 is targeted for degradation during S phase and G2 to allow mitotic entry. Wee1 is an essential tyrosine kinase required for the G2/M transition and S-phase progression. Although several studies have concentrated on Wee1 regulation during mitosis, few have elucidated its degradation during interphase. Our prior studies have demonstrated that Wee1 is degraded via CK1δ dependent phosphorylation during the S and G2/M phases of the cell cycle. Here we demonstrate that GSK3β may work in concert with CK1δ to induce Wee1 destruction during interphase. We generated small molecules that specifically stabilized Wee1. We profiled these compounds against 296 kinases and found that they inhibit GSK3α and GSK3β, suggesting that Wee1 may be targeted for proteolysis by GSK3. Consistent with this notion, known GSK3 inhibitors stabilized Wee1 and GSK3β depletion reduced Wee1 turnover. Given Wee1's central role in cell cycle progression, we predicted that GSK3 inhibitors should limit cell proliferation. Indeed, we demonstrate that GSK3 inhibitors potently inhibited proliferation of the most abundant cell in the mammalian brain, the cerebellar granule cell progenitor (GCP). These studies identify a previously unappreciated role for GSK3β mediated regulation of Wee1 during the cell cycle and in neurogenesis. Furthermore, they suggest that pharmacological inhibition of Wee1 may be therapeutically attractive in some cancers where GSK-3β or Wee1 are dysregulated.
The evolution of tenascins and fibronectin
Creators: name: Adams, Josephine C
name: Chiquet-Ehrismann, Ruth
name: Tucker, Richard P
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: Tenascins are extracellular matrix glycoproteins that act both as integrin ligands and as modifiers of fibronectin-integrin interactions to regulate cell adhesion, migration, proliferation and differentiation. In tetrapods, both tenascins and fibronectin bind to integrins via RGD and LDV-type tripeptide motifs found in exposed loops in their fibronectin-type III domains. We previously showed that tenascins appeared early in the chordate lineage and are represented by single genes in extant cephalochordates and tunicates. Here we have examined the genomes of the coelacanth Latimeria chalumnae, the elephant shark Callorhinchus milii as well as the lampreys Petromyzon marinus and Lethenteron japonicum to learn more about the evolution of the tenascin gene family as well as the timing of the appearance of fibronectin during chordate evolution. The coelacanth has 4 tenascins that are more similar to tetrapod tenascins than are tenascins from ray-finned fishes. In contrast, only 2 tenascins were identified in the elephant shark and the Japanese lamprey L. japonicum. An RGD motif exposed to integrin binding is observed in tenascins from many, but not all, classes of chordates. Tetrapods that lack this RGD motif in tenascin-C have a similar motif in the paralog tenascin-W, suggesting the potential for some overlapping function. A predicted fibronectin with the same domain organization as the fibronectin from tetrapods is found in the sea lamprey P. marinus but not in tunicates, leading us to infer that fibronectin first appeared in vertebrates. The motifs that recognize LDV-type integrin receptors are conserved in fibronectins from a broad spectrum of vertebrates, but the RGD integrin-binding motif may have evolved in gnathostomes.
Pocket analysis of the full-length cholix toxin. An assessment of the structure–dynamics of the apo catalytic domain
Creators: name: Lugo, Miguel R.
name: A. Rod Merrill
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Molecular Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry
subject: Biophysics

description: Cholix toxin from Vibrio cholerae is the third member of the diphtheria toxin (DT) group of mono-ADP-ribosyltransferase (mART) bacterial toxins. It shares structural and functional properties with Pseudomonas aeruginosa exotoxin A and Corynebacterium diphtheriae DT. Cholix toxin is an important model for the development of antivirulence approaches and therapeutics against these toxins from pathogenic bacteria. Herein, we have used the high-resolution X-ray structure of full-length cholix complexed with NAD+ to describe the properties of the NAD+-binding pocket at the residue level, including the role of crystallographic water molecules in the NAD+ substrate interaction. The full-length apo cholix structure is used to describe the putative NAD+-binding site(s) and to correlate biochemical with crystallographic data to study the stoichiometry and orientation of bound NAD+ molecules. We quantitatively describe the NAD+ substrate interactions on a residue basis for the main 22 pocket residues in cholixf, a glycerol and 5 contact water molecules as part of the recognition surface by the substrate according to the conditions of crystallization. In addition, the dynamic properties of an in silico version of the catalytic domain were investigated in order to understand the lack of electronic density for one of the main flexible loops (R-loop) in the pocket of X-ray complexes. Implications for a rational drug design approach for mART toxins are derived.
MySciBlog Survey Instrument
Creators: name: Jarreau, Paige B
Publisher: name: figshare
Year: 2015
Subjects: subject: 200104 Media Studies
subject: FOS: Media and communications
subject: Applied Psychology
subject: Sociology
subject: FOS: Sociology

description: #MySciBlog Survey instrument and select topline frequency report. Survey of 610 science bloggers in 2014. All data collected by Paige Brown Jarreau, for dissertation work at Louisiana State University.
GSK3 Inhibitors Stabilize Wee1 and Reduce Cerebellar Granule Cell Progenitor Proliferation
Creators: name: Penas, Clara
name: Jitendra K Mishra
name: Wood, Spencer D
name: Schürer, Stephan C
name: Roush, William R
name: Ayad, Nagi G
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Pharmacology
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Molecular Biology
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Ubiquitin mediated proteolysis is required for transition from one cell cycle phase to another. For instance, the mitosis inhibitor Wee1 is targeted for degradation during S phase and G2 to allow mitotic entry. Wee1 is an essential tyrosine kinase required for the G2/M transition and S-phase progression. Although several studies have concentrated on Wee1 regulation during mitosis, few have elucidated its degradation during interphase. Our prior studies have demonstrated that Wee1 is degraded via CK1δ dependent phosphorylation during the S and G2/M phases of the cell cycle. Here we demonstrate that GSK3β may work in concert with CK1δ to induce Wee1 destruction during interphase. We generated small molecules that specifically stabilized Wee1. We profiled these compounds against 296 kinases and found that they inhibit GSK3α and GSK3β, suggesting that Wee1 may be targeted for proteolysis by GSK3. Consistent with this notion, known GSK3 inhibitors stabilized Wee1 and GSK3β depletion reduced Wee1 turnover. Given Wee1's central role in cell cycle progression, we predicted that GSK3 inhibitors should limit cell proliferation. Indeed, we demonstrate that GSK3 inhibitors potently inhibited proliferation of the most abundant cell in the mammalian brain, the cerebellar granule cell progenitor (GCP). These studies identify a previously unappreciated role for GSK3β mediated regulation of Wee1 during the cell cycle and in neurogenesis. Furthermore, they suggest that pharmacological inhibition of Wee1 may be therapeutically attractive in some cancers where GSK-3β or Wee1 are dysregulated.
Fifteenth Thing: Research impact at the University of Melbourne
Creators: name: LEWIS, JENNIFER
Publisher: name: The University of Melbourne
Year: 2024
Subjects: classificationCode: 460909
subject: Information systems philosophy, research methods and theory

description: ‘Research impact’ is used all over the University of Melbourne in conversations – as well as in other universities in Australia and around the world. But what does it mean? How can we plan for it? What does the University do to support it? Find out more in this Thing, written by Professor Jenny Lewis.In the last two decades, there has been a growing emphasis on universities being able to demonstrate their world-changing capabilities. While there is a policy ‘push’ towards demonstrating that universities are relevant, and a good investment of public funds, there is also a ‘pull’ as students and academics are keen to ‘make a difference in the world’.The Advancing Melbourne strategy states that “[f]undamental investigator-driven research is the engine of discovery” (p12). The University aims to be at the leading edge of discovery, understanding, and impact, through research. It wants to increase its research impact capability by improving its impact culture, support, and visibility.
Roadmap on CeOS in the Balkans - Summary (Danish)
Creators: name: Dakić, Nataša
name: Trtovac, Aleksandra
Publisher: name: Zenodo
Year: 2023
Subjects: open science
citizen science
Balkans
university libraries
collaboration

description: This document is the summary of the Roadmap on CeOS in the Balkans (10.5281/zenodo.8383149), translated in Danish.
GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation
Creators: name: Penas, Clara
name: Jitendra K Mishra
name: Wood, Spencer D
name: Schürer, Stephan C
name: Roush, William R
name: Ayad, Nagi G
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Pharmacology
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Molecular Biology
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Ubiquitin mediated proteolysis is required for transition from one cell cycle phase to another. For instance, the mitosis inhibitor Wee1 is targeted for degradation during S phase and G2 to allow mitotic entry. Wee1 is an essential tyrosine kinase required for the G2/M transition and S-phase progression. Although several studies have concentrated on Wee1 regulation during mitosis, few have elucidated its degradation during interphase. Our prior studies have demonstrated that Wee1 is degraded via CK1δ dependent phosphorylation during the S and G2/M phases of the cell cycle. Here we demonstrate that GSK3β may work in concert with CK1δ to induce Wee1 destruction during interphase. We generated small molecules that specifically stabilized Wee1. We profiled these compounds against 296 kinases and found that they inhibit GSK3α and GSK3β, suggesting that Wee1 may be targeted for proteolysis by GSK3. Consistent with this notion, known GSK3 inhibitors stabilized Wee1 and GSK3β depletion reduced Wee1 turnover. Given Wee1's central role in cell cycle progression, we predicted that GSK3 inhibitors should limit cell proliferation. Indeed, we demonstrate that GSK3 inhibitors potently inhibited proliferation of the most abundant cell in the mammalian brain, the cerebellar granule cell progenitor (GCP). These studies identify a previously unappreciated role for GSK3β mediated regulation of Wee1 during the cell cycle and in neurogenesis. Furthermore, they suggest that pharmacological inhibition of Wee1 may be therapeutically attractive in some cancers where GSK-3β or Wee1 are dysregulated.
title: Novel Architecture of Costal Cartilage and Implications in Chest Wall Deformities
Creators: name: Asmar, Anthony J.
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2013

description: Costal cartilage is a type of hyaline cartilage that forms rod-like structures that connect the ribs to the sternum. Deformation of costal cartilage is observed in the chest wall deformities, pectus excavatum and pectus carinatum. Pectus excavatum involves a sternal displacement causing a depression of the chest while pectus carinatum causes a protrusion of the chest. As costal cartilage is not a widely studied tissue, this leaves little knowledge into possible factors involved in the pathogenesis of pectus deformities. Costal cartilage in these deformities has been described as being weakened and may implicate proteoglycans which play an important role in the structure and maintenance of the extracellular matrix. This study focused on the major proteoglycans aggrecan, biglycan, and decorin. Immunohistochemistry and western blot analysis of these proteoglycans was performed on costal cartilage from patients with pectus deformities along with an age-matched control. Western blotting was also performed on normal costal cartilage from fetal, adolescent, and adult tissue to observe any changes in relation to age. We demonstrated that aggrecan forms distinct patterns of localization. Western blot analysis of biglycan and decorin indicated that these proteoglycans exist in a proform and mature form of different sizes likely based on varied N-glycanation. Both forms of biglycan and prodecorin were present in fetal. adolescent, and adult tissue while mature decorin was present in adolescent and adult tissue suggesting biglycan has a greater role in early costal cartilage development. Immunohistochemistry of biglycan and decorin showed both proteoglycans localized in the territorial matrix but not the interterritorial matrix and may be indicative of an alternative method of collagen organization or hindered visualization caused by the formation of large collagen "nanostraws." Further studies will be performed to establish the functional differences of the different glycanated forms of biglycan and decorin as well as their inclusion in collagen fibrils.
Conditional Distance Correlation
Creators: name: Xueqin Wang
name: Wenliang Pan
name: Wenhao Hu
name: Tian, Yuan
name: Heping Zhang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Statistical inference on conditional dependence is essential in many fields including genetic association studies and graphical models. The classic measures focus on linear conditional correlations and are incapable of characterizing nonlinear conditional relationship including nonmonotonic relationship. To overcome this limitation, we introduce a nonparametric measure of conditional dependence for multivariate random variables with arbitrary dimensions. Our measure possesses the necessary and intuitive properties as a correlation index. Briefly, it is zero almost surely if and only if two multivariate random variables are conditionally independent given a third random variable. More importantly, the sample version of this measure can be expressed elegantly as the root of a V or U-process with random kernels and has desirable theoretical properties. Based on the sample version, we propose a test for conditional independence, which is proven to be more powerful than some recently developed tests through our numerical simulations. The advantage of our test is even greater when the relationship between the multivariate random variables given the third random variable cannot be expressed in a linear or monotonic function of one random variable versus the other. We also show that the sample measure is consistent and weakly convergent, and the test statistic is asymptotically normal. By applying our test in a real data analysis, we are able to identify two conditionally associated gene expressions, which otherwise cannot be revealed. Thus, our measure of conditional dependence is not only an ideal concept, but also has important practical utility. Supplementary materials for this article are available online.
Conditional distance correlation
Creators: name: Xueqin Wang
name: Wenliang Pan
name: Wenhao Hu
name: Tian, Yuan
name: Heping Zhang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Genetics
subject: Medicine

description: Statistical inference on conditional dependence is essential in many fields including genetic association studies and graphical models. The classic measures focus on linear conditional correlations, and are incapable of characterizing non-linear conditional relationship including non-monotonic relationship. To overcome this limitation, we introduces a nonparametric measure of conditional dependence for multivariate random variables with arbitrary dimensions. Our measure possesses the necessary and intuitive properties as a correlation index. Briefly, it is zero almost surely if and only if two multivariate random variables are conditionally independent given a third random variable. More importantly, the sample version of this measure can be expressed elegantly as the root of a V or U-process with random kernels and has desirable theoretical properties. Based on the sample version, we propose a test for conditional independence, which is proven to be more powerful than some recently developed tests through our numerical simulations. The advantage of our test is even greater when the relationship between the multivariate random variables given the third random variable cannot be expressed in a linear or monotonic function of one random variable versus the other. We also show that the sample measure is consistent and weakly convergent, and the test statistic is asymptotically normal. By applying our test in a real data analysis, we are able to identify two conditionally associated gene expressions, which otherwise cannot be revealed. Thus, our measure of conditional dependence is not only an ideal concept, but also has important practical utility.
Efficient Green Approach for the Synthesis of Spiro[indoline-3,4′-pyrazolo[3,4-b]quinoline]diones Using [NMP]H2PO4 and Solvatochromic and pH Studies
Creators: name: Kumari, Sudesh
name: Jayant Sindhu
name: J. M. Khurana
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Physiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: A mild and efficient protocol for the synthesis of spiro[indoline-3,4′-pyrazolo[3,4-b]quinoline]diones via a one-pot, three-component condensation of isatins, 1,3-dicarbonyls, and 5-amino-1-phenyl-3-methylpyrazole using [NMP]H2PO4 as a catalyst in EtOH/H2O is described. The catalyst could be recycled and reused four times without significant loss of activity. Spiro[indoline-3,4′-pyrazolo[3,4-b]quinoline]diones with stabilized zwitter ionic resonance structures showed feasible application as new fluorescent probes and pH indicators. These chemosensors have a good wavelength shift and showed excellent sensitivity in the range of pH from 11 to 13.
Sixteenth Thing: Research Management as a Profession
Creators: name: COCO, ANNE
Publisher: name: The University of Melbourne
Year: 2024
Subjects: classificationCode: 460909
subject: Information systems philosophy, research methods and theory

description: In the world of research, the pursuit of knowledge and breakthrough discoveries requires not only the brilliance of researchers but also the guidance and support of research management professionals. Research management professionals play a vital role in facilitating and enhancing the research process, as discussed in this Thing by Anne Coco.Overview of Research Management: Enabling and Supporting ResearchResearch management encompasses a wide range of activities aimed at enabling and supporting research projects. It involves the coordination and administration of research initiatives, ensuring compliance with regulations and ethical standards, and securing funding to sustain research activities. Research management professionals act as catalysts for innovation and collaboration and aim to create an environment where researchers can thrive and produce impactful outcomes.
In silico characterization of binding mode of CCR8 inhibitor: homology modeling, docking and membrane based MD simulation study
Creators: name: Changdev G. Gadhe
name: Balupuri, Anand
name: Cho, Seung Joo
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Pharmacology
Biochemistry
Biophysics

description: Human CC-chemokine receptor 8 (CCR8) is a crucial drug target in asthma that belongs to G-protein-coupled receptor superfamily, which is characterized by seven transmembrane helices. To date, there is no X-ray crystal structure available for CCR8; this hampers active research on the target. Molecular basis of interaction mechanism of antagonist with CCR8 remains unclear. In order to provide binding site information and stable binding mode, we performed modeling, docking and molecular dynamics (MD) simulation of CCR8. Docking study of biaryl-ether-piperidine derivative (13C) was performed inside predefined CCR8 binding site to get the representative conformation of 13C. Further, MD simulations of receptor and complex (13C-CCR8) inside dipalmitoylphosphatidylcholine lipid bilayers were performed to explore the effect of lipids. Results analyses showed that the Gln91, Tyr94, Cys106, Val109, Tyr113, Cys183, Tyr184, Ser185, Lys195, Thr198, Asn199, Met202, Phe254, and Glu286 were conserved in both docking and MD simulations. This indicated possible role of these residues in CCR8 antagonism. However, experimental mutational studies on these identified residues could be effective to confirm their importance in CCR8 antagonism. Furthermore, calculated Coulombic interactions represented the crucial roles of Glu286, Lys195, and Tyr113 in CCR8 antagonism. Important residues identified in this study overlap with the previous non-peptide agonist (LMD-009) binding site. Though, the non-peptide agonist and currently studied inhibitor (13C) share common substructure, but they differ in their effects on CCR8. So, to get more insight into their agonist and antagonist effects, further side-by-side experimental studies on both agonist (LMD-009) and antagonist (13C) are suggested.
Data Management Plan
Creators: name: Gul, Sheraz
name: Bartunek, Petr
name: Škuta, Ctibor
name: Voršilák, Milan
Publisher: name: Zenodo
Year: 2024
Subjects: Research Infrastructure
Data Management

description: [Draft deliverable; under review by the EC] The EU-OPENSCREEN Research Infrastructure, a leading European Research Infrastructure Consortium (ERIC) for chemical biology and early drug discovery (https://www.eu-openscreen.eu/), offers services in high-throughput compound screening and medicinal chemistry to both academic and industrial users. As such, EU-OPENSCREEN is pivotal in advancing early-stage drug discovery in Europe. To meet the growing complexity of modern drug discovery research, EU-OPENSCREEN has recently expanded its services to include fragment-based drug discovery and chemoproteomics. The IMPULSE project will further enhance EU-OPENSCREEN by developing and integrating new services in AI/ML, novel chemical modalities and cutting-edge cell models combined with CRISPRCas9/RNAi-based genetic screening. Additionally, IMPULSE will implement standardised operational and data practices to improve reproducibility and data quality, while tailored outreach and training programmes will increase both awareness of the EU-OPENSCREEN’s activities and the operational excellence of the ERIC. These efforts, along with new partnerships with industry and  charities, will ensure the long-term sustainability and accessibility of EU-OPENSCREEN’s comprehensive service portfolio. 

This Data Management Plan specifies the datasets that will be collected, used, and re-used during the IMPULSE project, detailing how data will be handled both during and after the project. It outlines the methodologies and standards to be applied, as well as the measures for preserving data beyond the IMPULSE completion. A list of IMPULSE work-packages is available as appendix.
An Efficient Green Approach for the Synthesis of spiro[indoline-3,4′-pyrazolo[3,4-b]quinoline]diones Using [NMP]H2PO4, Their Solvatochromic and pH Studies
Creators: name: Kumari, Sudesh
name: Jayant Sindhu
name: J. M. Khurana
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Physiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: A mild and efficient protocol for the synthesis of spiro[indoline-3,4′-pyrazolo[3,4-b]quinoline]diones via a one pot three component condensation of isatins, 1,3-dicarbonyls and 5-amino-1-phenyl-3-methylpyrazole using [NMP]H2PO4 as a catalyst in EtOH: H2O is described. The catalyst could be recycled and reused four times without significant loss of activity. Spiro[indoline-3,4′-pyrazolo[3,4-b]quinoline]diones with stabilized zwitter ionic resonance structures showed feasible application as new fluorescent probes and pH indicators. These chemosensors have a good wavelength shift and showed excellent sensitivity in the range of pH from 11 to 13.
Kinetic Modeling of Magnetic Field Dynamics and Thermal Energy Transport in Inertial Fusion Energy Plasmas
Creators: name: Joglekar, Archis
Publisher: name: Zenodo
Year: 2016

description: In indirect-drive inertial-fusion experiments, a hohlraum converts laser energy into X-rays that heat an ablator material on a fuel capsule. The expansion of the ablator leads to implosion of the fuel capsule and fusion conditions in a hot spot, where alpha particles are produced and propagate a burn wave through the fuel. Accurate determination of the bal- ance of energy fluxes in the hohlraum not only requires consideration of X-ray transport, but also needs careful treatment of electron transport, because laser energy is coupled primarily to the electrons in the plasma. The steep electron-thermal-energy gradients in this environment can lead to breakdown of diffusive heat-transport and introduce non-local effects. Additionally, the plasmas produced in such laser-plasma experiments are subject to the influence of self-generated magnetic fields. A kinetic formulation enables detailed calculations of thermal-energy transport and magnetic-field dynamics in these plasmas due to self-consistent inclusion of effects in electron transport that depend not only on details of the particle energy distribution but also on the electromagnetic fields in the plasma. The dis- sertation describes novel comparisons between Braginskii transport and kinetic modeling that quantify the importance of kinetic effects. In addition to the theoretical contributions and modeling results, the author was also responsible for the development of a ray-tracing module to model laser propagation. Through kinetic modeling, the heat flow near the laser heating region retains non-local effects. In the case of an externally applied magnetic field, non-local contributions to the Nernst effect increase the rate of field transport by the Nernst mechanism. The Nernst effect leads to significantly faster transport of the magnetic field to the hohlraum axis in comparison to field transport through plasma hydrodynamic motion only. The self-generated magnetic fields are oppositely aligned with respect to each other and and are subject to reconnection. The magnetic reconnection mechanism is, in this case, governed by heat flow that transports the magnetic field. This mechanism is prevalent in plasmas where the thermal energy density is higher than the magnetic energy density. Such an environment is present in hohlraums near the critical surface, where reconnection results in redistribution of the thermal energy.
Geology of Mar Piccolo, Taranto (southern Italy): the physical basis for remediation of a polluted marine area
Creators: name: Lisco, Stefania
name: Corselli, Cesare
name: Giosa, Francesco De
name: Mastronuzzi, Giuseppe
name: Moretti, Massimo
name: Siniscalchi, Agata
name: Marchese, Fabio
name: Bracchi, Valentina
name: Tessarolo, Chiara
name: Tursi, Angelo
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences

description: Four 1:15,000 maps for the coastal area of Mar Piccolo (Taranto, southern Italy) are presented. The study area is a small, sheltered shallow marine basin of about 20 km2, located north of Taranto town. It contains some submarine, karstic freshwater springs (citri) that have determined the development of intensive aquaculture in the past. Now, the Mar Piccolo is a highly polluted area due to the presence of both military and industrial navy docks and various heavy industries located in proximal areas: (i) the ILVA steel plant in Taranto, the largest in Europe; (ii) the ENI oil refinery and (iii) the CEMENTIR, the largest cement and concrete plant in southern Italy. Many studies show that water and sediments are contaminated (heavy metals, isopropyl alcohol, polychlorinated biphenyl [PCB], etc.), and various remediation projects are now in preparation. In this study, we analyze the physical characteristics of the Mar Piccolo environment by producing several maps: a geological map; a geomorphological map; a bathy-morphological map and a map of the thickness of surficial sediment. All these maps are original products focused on the realization of a reliable geological picture for the Mar Piccolo area. They represent the first steps toward the detailed knowledge of the Mar Piccolo physical environment, which we consider to be a fundamental requirement for developing the most appropriate remediation techniques.
Alternative Markets for Cattle Hide Trim
Creators: name: Poats, Frederick J.
name: Thompson, John W.
name: Poats, Frederick J.
name: Thompson, John W.
Publisher: name: Unknown
Year: 1965
Subjects: subject: Livestock Production/Industries
subject: Marketing
subject: FOS: Economics and business
subject: Research and Development/Tech Change/Emerging Technologies

description: Excerpts from the report: This report has been prepared to help the hide and leather industry improve the competitive position of leather and increase returns to packers for hides. Returns to packers for cattle hides can be greater when shanks, bellies, and heads are removed prior to curing. New markets for portions trimmed from hides can increase returns. Currently, the tannery market price for cured bellies and heads is about 2 cents a pound. At this price, no share is left to pay the processing and marketing costs of the packer. An evaluation of alternative markets indicates that fresh hide trimmings have a value of about 2 cents a pound if they are converted into edible collagen, or rendered into feed and oil by a new process.