cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dissemination and genome analysis of high-level ceftriaxone-resistant penA 60.001 Neisseria gonorrhoeae strains from the Guangdong Gonococcal antibiotics susceptibility Programme (GD-GASP), 2016–2019
Creators: name: Lin, Xiaomian
name: Chen, Wentao
name: Xie, Qinghui
name: Yu, Yuqi
name: Liao, Yiwen
name: Feng, Zhanjin
name: Qin, Xiaolin
name: Wu, Xingzhong
name: Tang, Sanmei
name: Zheng, Heping
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Background: After Neisseria gonorrhoeae FC428 was first found in Japan, ceftriaxone-resistant strains disseminated globally, and the gonococcal resistance rate increased remarkably. Epidemiological investigations are greatly significant for the analysis of antimicrobial resistance (AMR) trends, molecular features and evolution. Objectives: To clarify the AMR trend from 2016–2019 and reveal the molecular characteristics and evolution of ceftriaxone-resistant penA 60.001 isolates. Methods: The minimum inhibitory concentrations (MICs) of antibiotics against 4113 isolates were detected by the agar dilution method. N. gonorrhoeae multiantigen sequence typing (NG-MAST), multilocus sequence typing (MLST) and N.gonorrhoeae sequence typing for antimicrobial resistance (NG-STAR) were used to identify the sequence types. Genome analysis was conducted to analyze resistance genes, virulence factors, and evolutionary sources. Results: Isolates with decreased ceftriaxone susceptibility have increased from 2.05% (2016) to 16.18% (2019). Six ceftriaxone-resistant isolates possessing penA 60.001 appeared in Guangdong Province, and were resistant to ceftriaxone, penicillin, tetracycline, ciprofloxacin and cefixime, but susceptible to azithromycin and spectinomycin. Single-nucleotide polymorphisms (SNPs) in the porB gene were the major cause of different NG-MAST types. ST1903 was the main NG-STAR genotype and only strain-ZH545 was ST7365, with molecular features consistent with the MICs. Furthermore, different MLSTs suggested diverse evolutionary sources. Genome analysis revealed a set of virulence factors along with the resistance genes “penA” and “blaTEM-1B”. Half of penA 60.001 strains were fully mixed with global FC428-related strains. Conclusions: Global FC428-related clones have disseminated across Guangdong, possibly causing decreased ceftriaxone susceptibility. Enhanced gonococcal surveillance will help elucidate the trajectory of transmission and curb further dissemination.
SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION, X-RAY ANALYSIS OF  DMSO SOLVATED 5'-CHLORO-1H,1"H-[3,3':3',3"-TERINDOL]-2'(1'H)-ONE
Creators: name: Sharma, Sakshi
name: Brahmachari, Goutam
name: Banerjee, Bubun
name: Kant, Rajni
name: Gupta, Vivek K.
Publisher: name: European Chemical Bulletin
Year: 2015

description: The title compound 5'-Chloro-1H,1"H-[3,3':3',3"-terindol]-2'(1'H)-one is synthesized via one-pot multicomponent reaction (MCR) at room temperature using commercially available sulfamic acid as inexpensive and environmentally benign organo-catalyst. It crystallizes in the monoclinic space group P21/n with the unit-cell parameters: a = 15.3117(15), b = 10.9302(8), c = 16.591(2) Å, a = 90.00o β = 98.224(10)° , γ = 90.00° and Z = 4. The crystal structure was solved by direct methods using single-crystal X-ray diffraction data collected at room temperature and refined by full-matrix least-squares procedures to a final R-value of 0.0735 for 2539 observed reflections. Both the DMSO solvent molecules take part in the inter- and intramolecular interactions that are responsible for the formation of hydrogen bonded network. Two C-H∙∙∙π inter-molecular hydrogen bonds are also present in the crystal structure.
description: European Chemical Bulletin, Vol 4, No 7-9 (2015): European Chemical Bulletin
ATMO-ACCESS WP7 MS32 Completion of 3rd programme revision with WP4-6 recommendation
Creators: name: McFiggans, Gordon
name: Wenger, John
Publisher: name: Zenodo
Year: 2024

description: This document represents the 'Completion of 3rd Programme Revision with WP4-6 Recommendation', a milestone (M32) of the ATMO-ACCESS project (Solutions for Sustainable Access to Atmospheric Research Facilities). It reflects the collaborative efforts of distributed atmospheric research facilities to develop a pilot for a new model of Integrating Activities. The goal of ATMO-ACCESS is to establish a programme that provides access to multiple atmospheric research infrastructures, either individually or in combination.WP7 is responsible for integrating the various access modalities and pilot programmes suggested by the other WPs into a comprehensive programme that offers physical, remote, and virtual access. This programme is subject to continuous updates to include novel Transnational Access (TNA) calls, as the aim is to strategically develop access modalities.WP7 members designed the programme after consulting with WP4-6 leaders and the Coordination, and it was ratified by the Strategic TNA/VA Access Board (STVB).
A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses
Creators: name: Wang, Pengfei
name: Casner, Ryan G.
name: Nair, Manoj S.
name: Yu, Jian
name: Guo, Yicheng
name: Wang, Maple
name: Chan, Jasper F.-W.
name: Cerutti, Gabriele
name: Iketani, Sho
name: Liu, Lihong
name: Sheng, Zizhang
name: Chen, Zhiwei
name: Yuen, Kwok-Yung
name: Kwong, Peter D.
name: Huang, Yaoxing
name: Shapiro, Lawrence
name: Ho, David D.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The repeated emergence of highly pathogenic human coronaviruses as well as their evolving variants highlight the need to develop potent and broad-spectrum antiviral therapeutics and vaccines. By screening monoclonal antibodies (mAbs) isolated from COVID-19-convalescent patients, we found one mAb, 2-36, with cross-neutralizing activity against SARS-CoV. We solved the cryo-EM structure of 2–36 in complex with SARS-CoV-2 or SARS-CoV spike, revealing a highly conserved epitope in the receptor-binding domain (RBD). Antibody 2–36 neutralized not only all current circulating SARS-CoV-2 variants and SARS-COV, but also a panel of bat and pangolin sarbecoviruses that can use human angiotensin-converting enzyme 2 (ACE2) as a receptor. We selected 2-36-escape viruses in vitro and confirmed that K378 T in SARS-CoV-2 RBD led to viral resistance. Taken together, 2–36 represents a strategic reserve drug candidate for the prevention and treatment of possible diseases caused by pre-emergent SARS-related coronaviruses. Its epitope defines a promising target for the development of a pan-sarbecovirus vaccine.
Additional file 1 of Diabetes and blood glucose monitoring knowledge and practices among pharmacy professionals in Cambodia and Viet Nam: digital survey and education
Creators: name: Haldane, Cathy
name: Neukom, Josselyn
name: Lailo, Jaca Maison
name: Hero, Kol
name: Vetter, Beatrice
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Supplementary Material 1
Impact of whole dairy matrix on musculoskeletal health and aging–current knowledge and research gaps
Creators: name: NRW Geiker
name: C Mølgaard
name: S Iuliano
name: R Rizzoli
name: Y Manios
name: LJC Van Loon
name: JM Lecerf
name: Moschonis, George
name: JY Reginster
name: I Givens
name: A Astrup
Publisher: name: La Trobe
Year: 2020
Subjects: Uncategorized

description: © 2019, International Osteoporosis Foundation and National Osteoporosis Foundation.
Dairy products are included in dietary guidelines worldwide, as milk, yoghurt, and cheese are good sources of calcium and protein, vital nutrients for bones and muscle mass maintenance. Bone growth and mineralization occur during infancy and childhood, peak bone mass being attained after early adulthood. A low peak bone mass has consequences later in life, including increased risk of osteoporosis and fractures. Currently, more than 200 million people worldwide suffer from osteoporosis, with approximately 9 million fractures yearly. This poses a tremendous economic burden on health care. Between 5% and 10% of the elderly suffer from sarcopenia, the loss of muscle mass and strength, further increasing the risk of fractures due to falls. Evidence from interventional and observational studies support that fermented dairy products in particular exert beneficial effects on bone growth and mineralization, attenuation of bone loss, and reduce fracture risk. The effect cannot be explained by single nutrients in dairy, which suggests that a combined or matrix effect may be responsible similar to the matrix effects of foods on cardiometabolic health. Recently, several plant-based beverages and products have become available and marketed as substitutes for dairy products, even though their nutrient content differs substantially from dairy. Some of these products have been fortified, in efforts to mimic the nutritional profile of milk, but it is unknown whether the additives have the same bioavailability and beneficial effect as dairy. We conclude that the dairy matrix exerts an effect on bone and muscle health that is more than the sum of its nutrients, and we suggest that whole foods, not only single nutrients, need to be assessed in future observational and intervention studies of health outcomes. Furthermore, the importance of the matrix effect on health outcomes argues in favor of making future dietary guidelines food based.
SUPPL-FiguresTablesCFA-REVISED.2020.06.29 – Supplemental material for Influences on help-seeking decisions for behavioral child sleep problems: Why parents do and do not seek help
Creators: name: Newton, Adam T
name: Corkum, Penny V
name: Blunden, Sarah
name: Reid, Graham J
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine

description: Supplemental material, SUPPL-FiguresTablesCFA-REVISED.2020.06.29 for Influences on help-seeking decisions for behavioral child sleep problems: Why parents do and do not seek help by Adam T Newton, Penny V Corkum, Sarah Blunden and Graham J Reid in Clinical Child Psychology and Psychiatry
Additional file 1 of Randomized, double-blind, placebo-controlled study to evaluate the effect of treatment with an SPMs-enriched oil on chronic pain and inflammation, functionality, and quality of life in patients with symptomatic knee osteoarthritis: GAUDI study
Creators: name: Möller, Ingrid
name: Rodas, Gil
name: Villalón, Jose María
name: Rodas, Jose A.
name: Angulo, Francisco
name: Martínez, Nina
name: Vergés, Josep
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. Blood test results (N = 51).
Immediate effects of foot orthoses on lower limb biomechanics, pain, and confidence in individuals with patellofemoral osteoarthritis
Creators: name: Tan, Jade
name: Middleton, Kane
name: Hart, Harvi
name: Menz, Hylton
name: Crossley, Kay
name: Munteanu, Shannon
name: Collins, Natalie
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 4003
subject: Biomedical engineering
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 4207
subject: Sports science and exercise

description: © 2019 Elsevier
Background: Foot orthoses are a recommended treatment for patellofemoral (PF) pain and a number of lower limb osteoarthritic (OA) conditions. However, their mechanism of effect is poorly understood. Research question: To compare the immediate effects of foot orthoses and flat inserts on lower limb biomechanics, knee pain and confidence in individuals with PFOA. Methods: Twenty-one participants (14 females; mean ± SD age 58 ± 8 years) with PFOA underwent three-dimensional motion analysis during level-walking, stair ascent, and stair descent under three footwear conditions: (i) their own shoes; (ii) prefabricated foot orthoses; and (iii) flat shoe inserts. Participants reported their average levels of knee pain and confidence after each task. Data were analysed with repeated-measures analysis of variance (ANOVA), effect sizes (partial eta squared), and Bonferroni post-hoc tests. Results: During level-walking, there was a significant main effect of foot orthoses on peak ankle dorsiflexion angle (F2 = 0.773, p < 0.001, ƞ2 = 0.773) and peak ankle external dorsiflexion moment (F2 = 0.356, p = 0.046, ƞ2 = 0.356). Foot orthoses decreased the peak ankle dorsiflexion angle compared to the flat insert and shoe conditions, and decreased the peak ankle external dorsiflexion moment relative to flat inserts. During stair descent, there was a significant main effect of foot orthoses on peak ankle external dorsiflexion moment (F2 = 0.823, p = 0.006, ƞ2 = 0.738), with a trend towards lower peak dorsiflexion moment for foot orthoses compared to the flat insert and shoe conditions. No significant main effects were observed during stair ascent. No other lower limb biomechanical changes were observed across all three conditions. Knee pain and confidence scores were not significantly different across the three conditions. Significance: Prefabricated foot orthoses altered sagittal plane biomechanics of the ankle during level-walking and stair descent in individuals with PFOA. Further research is required to determine whether these changes are clinically beneficial.
Global Names Architecture tools for verification, normalization, and detection of scientific names.
Creators: name: Mozzherin, Dmitry
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Global Names Architecture tools for verification, normalization, and detection of scientific names. by Dmitry Mozzherin of University Of Illinois at Champaign/Urbana Champaign United States for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Production training and contextual similarity hurt the comprehension of new vocabulary
Creators: name: Waller, Megan
name: Yurovsky, Daniel
name: Nozari, Nazbanou
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Molecular Biology
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: In two experiments (N = 179), we studied the effects of contextual similarity and training mode on the comprehension of new vocabulary. Participants were trained on new vocabulary in blocks of semantically similar, phonologically similar, or unrelated items. Each participant was trained through passive exposure, active comprehension, or active production. Same number of items were trained in clusters of 9 in Experiment 1 and clusters of 3 in Experiment 2, manipulating difficulty during training. Results showed a detrimental and persistent effect of semantic similarity, and a less robust effect of phonological similarity, both of which grew larger over time. We also found a negative and largely independent influence of production mode on learning, which, contrary to the similarity effect, shrank with time. Neither effect was modulated by difficulty at training time. These findings shed further light on the factors influencing new vocabulary learning and open new avenues for larger-scale and classroom-level studies.
A CRISPR/Cas12a-based DNAzyme visualization system for rapid, non-electrically dependent detection of Bacillus anthracis
Creators: name: Wang, Dongshu
name: Chen, Gang
name: Lyu, Yufei
name: Feng, Erling
name: Zhu, Li
name: Pan, Chao
name: Zhang, Weicai
name: Liu, Xiankai
name: Wang, Hengliang
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: As next-generation pathogen detection methods, CRISPR-Cas-based detection methods can perform single-nucleotide polymorphism (SNP) level detection with high sensitivity and good specificity. They do not require any particular equipment, which opens up new possibilities for the accurate detection and identification of Bacillus anthracis. In this study, we developed a complete detection system for B. anthracis based on Cas12a. We used two chromosomally located SNP targets and two plasmid targets to identify B. anthracis with high accuracy. The CR5 target is completely new. The entire detection process can be completed within 90 min without electrical power and with single-copy level sensitivity. We also developed an unaided-eye visualization system based on G4-DNAzyme for use with our CRISPR-Cas12a detection system. This visualization system has good prospects for deployment in field-based point-of-care detection. We used the antisense nucleic acid CatG4R as the detection probe, which showed stronger resistance to interference from components of the solution. CatG4R can also be designed as an RNA molecule for adaptation to Cas13a detection, thereby broadening the scope of the detection system.
Immediate effects of foot orthoses on lower limb biomechanics, pain, and confidence in individuals with patellofemoral osteoarthritis
Creators: name: Tan, Jade
name: Middleton, Kane
name: Harvi Hart
name: Menz, Hylton
name: Crossley, Kay
name: Munteanu, Shannon
name: Collins, Natalie J
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2019 Elsevier
Background: Foot orthoses are a recommended treatment for patellofemoral (PF) pain and a number of lower limb osteoarthritic (OA) conditions. However, their mechanism of effect is poorly understood. Research question: To compare the immediate effects of foot orthoses and flat inserts on lower limb biomechanics, knee pain and confidence in individuals with PFOA. Methods: Twenty-one participants (14 females; mean ± SD age 58 ± 8 years) with PFOA underwent three-dimensional motion analysis during level-walking, stair ascent, and stair descent under three footwear conditions: (i) their own shoes; (ii) prefabricated foot orthoses; and (iii) flat shoe inserts. Participants reported their average levels of knee pain and confidence after each task. Data were analysed with repeated-measures analysis of variance (ANOVA), effect sizes (partial eta squared), and Bonferroni post-hoc tests. Results: During level-walking, there was a significant main effect of foot orthoses on peak ankle dorsiflexion angle (F2 = 0.773, p < 0.001, ƞ2 = 0.773) and peak ankle external dorsiflexion moment (F2 = 0.356, p = 0.046, ƞ2 = 0.356). Foot orthoses decreased the peak ankle dorsiflexion angle compared to the flat insert and shoe conditions, and decreased the peak ankle external dorsiflexion moment relative to flat inserts. During stair descent, there was a significant main effect of foot orthoses on peak ankle external dorsiflexion moment (F2 = 0.823, p = 0.006, ƞ2 = 0.738), with a trend towards lower peak dorsiflexion moment for foot orthoses compared to the flat insert and shoe conditions. No significant main effects were observed during stair ascent. No other lower limb biomechanical changes were observed across all three conditions. Knee pain and confidence scores were not significantly different across the three conditions. Significance: Prefabricated foot orthoses altered sagittal plane biomechanics of the ankle during level-walking and stair descent in individuals with PFOA. Further research is required to determine whether these changes are clinically beneficial.
Additional file 1 of A multimodal deep learning model to infer cell-type-specific functional gene networks
Creators: name: Afshar, Shiva
name: Braun, Patricia R.
name: Han, Shizhong
name: Lin, Ying
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Supplementary Tables and Figures.
Online_Supplemental_Appendix_ – Supplemental material for Predicting Community Adoption of Collective Impact in the United States: A National Scan
Creators: name: Boyer, Anne-Marie
name: Cooper, Katherine R.
name: Dougherty, Shaun M.
name: Wang, Rong
name: Shumate, Michelle
Publisher: name: SAGE Journals
Year: 2020
Subjects: Organisation and Management Theory
Public Administration

description: Supplemental material, Online_Supplemental_Appendix_ for Predicting Community Adoption of Collective Impact in the United States: A National Scan by Anne-Marie Boyer, Katherine R. Cooper, Shaun M. Dougherty, Rong Wang and Michelle Shumate in Nonprofit and Voluntary Sector Quarterly
Comparative case study of Estonia & Indonesia: the role of digital identity to deliver integrated public services
Creators: name: Akbarinaldi, Rhino
Publisher: name: unknown
Year: 2022
Subjects: subject: Estonia
subject: Integrated services digital networks--Government policy
subject: Comparative government
subject: Policy sciences
subject: Public administration
subject: Indonesia

description: e-KTP, or Kartu Tanda Penduduk Elektronik, is the government-issued identity document for Indonesia citizen. It received legal foundation through the parliament approval of Act No. 23/2006 regarding Population Administration. Although Indonesian government engaged nation-wide identity card replacement, citizens didn't receive different experience when accessing the public services. Aside from Indonesia, other countries are also pursuing digital identity implementation. One of the examples is Estonia. The purpose of this paper is to do comparative case study of Estonia and Indonesia to understand the role of digital identity to deliver integrated public services. The approach of the paper is qualitative methodology to identify the gaps in the digital framework and its supporting policies. Several suggestions will be included in the conclusion to spark further discussion about moving e-KTP beyond the corruption scandal and leverage it as the strategic tool to deliver better integrated public services for the citizen.
Comparative case study of Estonia & Indonesia: the role of digital identity to deliver integrated public services
Creators: name: Akbarinaldi, Rhino
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Integrated services digital networks--Government policy
subject: Policy sciences
subject: Estonia
subject: Indonesia
subject: Public administration
subject: Comparative government

description: e-KTP, or Kartu Tanda Penduduk Elektronik, is the government-issued identity document for Indonesia citizen. It received legal foundation through the parliament approval of Act No. 23/2006 regarding Population Administration. Although Indonesian government engaged nation-wide identity card replacement, citizens didn’t receive different experience when accessing the public services. Aside from Indonesia, other countries are also pursuing digital identity implementation. One of the examples is Estonia. The purpose of this paper is to do comparative case study of Estonia and Indonesia to understand the role of digital identity to deliver integrated public services. The approach of the paper is qualitative methodology to identify the gaps in the digital framework and its supporting policies. Several suggestions will be included in the conclusion to spark further discussion about moving e-KTP beyond the corruption scandal and leverage it as the strategic tool to deliver better integrated public services for the citizen.
A nurse should not be careless: processing presupposed meanings triggered by connectives
Creators: name: Wang, Tianyue
name: Liu, Lijie
name: Xu, Xiaodong
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology

description: Connectives are crucial in constructing coherent discourse by signalling relationships across sentences and triggering presuppositions. This event-related potential study investigated how the type and presence of connectives influence sentence processing. Participants read sentences with because, although, or no connective, where critical words were either congruent or incongruent with the clausal relation specified by connectives. Incongruent words elicited a larger N400 than congruent words, regardless of the connective type or its presence. In later processing stages, incongruency induced an extended N400 effect in concessive contexts but a P600 effect in causal and no-connective contexts. Additionally, a larger P600 was observed in concessive-congruent versus causal-congruent conditions, indicating a greater effort to reconcile the concessive-triggered presupposition with the proposition. These findings suggest that connective-triggered presuppositions constrain both the initial evaluation of language input against broad contextual knowledge and the subsequent integration into discourse representation, supporting an Evaluation and Integration model of presupposition processing.
Sequential infections with rhinovirus and influenza modulate the replicative capacity of SARS-CoV-2 in the upper respiratory tract
Creators: name: Essaidi-Laziosi, Manel
name: MSc, Catia Alvarez
name: Puhach, Olha
name: Sattonnet-Roche, Pascale
name: Torriani, Giulia
name: Tapparel, Caroline
name: Kaiser, Laurent
name: Eckerle, Isabella
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Although frequently reported since the beginning of the pandemic, questions remain regarding the impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) interaction with circulating respiratory viruses in coinfected patients. We here investigated dual infections involving early-pandemic SARS-CoV-2 and the Alpha variant and three of the most prevalent respiratory viruses, rhinovirus (RV) and Influenza A and B viruses (IAV and IBV), in reconstituted respiratory airway epithelial cells cultured at air-liquid interface. We found that SARS-CoV-2 replication was impaired by primary, but not secondary, rhino- and influenza virus infection. In contrast, SARS-CoV-2 had no effect on the replication of these seasonal respiratory viruses. Inhibition of SARS-CoV-2 correlated better with immune response triggered by RV, IAV and IBV than the virus entry. Using neutralizing antibody against type I and III interferons, SARS-CoV-2 blockade in dual infections could be partly prevented. Altogether, these data suggested that SARS-CoV-2 interaction with seasonal respiratory viruses would be modulated by interferon induction and could impact SARS-CoV-2 epidemiology when circulation of other respiratory viruses is restored.
Socially-mediated linguistic convergence and perceptions of social proximity
Creators: name: Kim, Christina S.
name: Chamorro, Gloria
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Structural priming – the tendency to re-use syntactic forms after exposure to those forms – fits into a broader pattern of convergence between interlocutors at various linguistic levels. While sentence-level convergence is often explained in terms of cognitive mechanisms like implicit learning, recent work suggests that it can function to manage social distance with an interlocutor, as has been demonstrated for phonetic accommodation. Two experiments are presented that show that structural convergence is mediated by a speaker’s perception of their social proximity to their interlocutor, and that these perceptions themselves can shift over the course of a conversation.
SRM_Background_Materials – Supplemental material for Assessing solar geoengineering research funders: Insights from two US public deliberations
Creators: name: Nelson, John P
name: Kaplan, Leah
name: Tomblin, David
Publisher: name: SAGE Journals
Year: 2020
Subjects: Geography

description: Supplemental material, SRM_Background_Materials for Assessing solar geoengineering research funders: Insights from two US public deliberations by John P Nelson, Leah Kaplan and David Tomblin in The Anthropocene Review
GRSciColl: How the Registry of Scientific Collection can help improve system interoperability and link data from different sources
Creators: name: Grosjean, Marie
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference poster on GRSciColl: How the Registry of Scientific Collection can help improve system interoperability and link data from different sources by Data Administrator Marie Grosjean of Data Administrator GBIF København Ø Denmark for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Obesity is related to incidence of patellofemoral osteoarthritis: the Cohort Hip and Cohort Knee (CHECK) study
Creators: name: Harvi Hart
name: Marienke Van Middelkoop
name: Stefanik, Joshua J
name: Crossley, Kay
name: Bierma-Zeinstra, Sita
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. To determine the longitudinal association of baseline body mass index and change in body mass index over 8 years to incident of patellofemoral osteoarthritis at the 8-year follow-up. A sample of 528 women and men, aged 45–65 years, with knee complaints and without radiographic evidence of patellofemoral and tibiofemoral osteoarthritis at baseline, were selected from the Cohort Hip and Cohort Knee cohort. Incidence of patellofemoral osteoarthritis was defined as presence of radiographic patellofemoral osteoarthritis (with or without tibiofemoral osteoarthritis) at the 8-year follow-up. Baseline body mass index data were categorized into normal, overweight, and obese weight-categories. Logistic regression analyses, adjusted for age and sex, were conducted to determine the association of baseline body mass index and change in body mass index to patellofemoral osteoarthritis incidence 8 years later. Obesity was associated with greater odds of radiographic patellofemoral osteoarthritis incident (odds ratio: 1.8 [95% CI 1.1, 3.1]) 8 years later. There were no significant associations observed between body mass index change over 8 years and incidence of radiographic patellofemoral osteoarthritis in overweight and obese individuals. Obesity is associated with increased odds of developing radiographic patellofemoral osteoarthritis 8 years later.
Dissemination and genome analysis of high-level ceftriaxone-resistant penA 60.001 Neisseria gonorrhoeae strains from the Guangdong Gonococcal Antibiotics Susceptibility Programme (GD-GASP), 2016-2019
Creators: name: Lin, Xiaomian
name: Chen, Wentao
name: Xie, Qinghui
name: Yu, Yuqi
name: Liao, Yiwen
name: Feng, Zhanjin
name: Qin, Xiaolin
name: Wu, Xingzhong
name: Tang, Sanmei
name: Zheng, Heping
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: After Neisseria gonorrhoeae FC428 was first found in Japan, ceftriaxone-resistant strains disseminated globally, and the gonococcal resistance rate increased remarkably. Epidemiological investigations are greatly significant for the analysis of antimicrobial resistance (AMR) trends, molecular features and evolution. To clarify the AMR trend from 2016-2019 and reveal the molecular characteristics and evolution of ceftriaxone-resistant penA 60.001 isolates. The minimum inhibitory concentrations (MICs) of antibiotics against 4113 isolates were detected by the agar dilution method. N. gonorrhoeae multiantigen sequence typing (NG-MAST), multilocus sequence typing (MLST) and N.gonorrhoeae sequence typing for antimicrobial resistance (NG-STAR) were used to identify the sequence types. Genome analysis was conducted to analyze resistance genes, virulence factors, and evolutionary sources. Isolates with decreased ceftriaxone susceptibility have increased from 2.05% (2016) to 16.18% (2019). Six ceftriaxone-resistant isolates possessing penA 60.001 appeared in Guangdong Province, and were resistant to ceftriaxone, penicillin, tetracycline, ciprofloxacin and cefixime, but susceptible to azithromycin and spectinomycin. Single-nucleotide polymorphisms (SNPs) in the porB gene were the major cause of different NG-MAST types. ST1903 was the main NG-STAR genotype and only strain-ZH545 was ST7365, with molecular features consistent with the MICs. Furthermore, different MLSTs suggested diverse evolutionary sources. Genome analysis revealed a set of virulence factors along with the resistance genes “penA” and “blaTEM-1B”. Half of penA 60.001 strains were fully mixed with global FC428-related strains. Global FC428-related clones have disseminated across Guangdong, possibly causing decreased ceftriaxone susceptibility. Enhanced gonococcal surveillance will help elucidate the trajectory of transmission and curb further dissemination.
Additional file 11 of Immune profiling of SARS-CoV-2 epitopes in asymptomatic and symptomatic pediatric and adult patients
Creators: name: Tornesello, Anna Lucia
name: Botti, Chiara
name: Micillo, Alberto
name: Labonia, Francesco
name: Arpino, Sergio
name: Isgrò, Maria Antonietta
name: Meola, Serena
name: Russo, Luigi
name: Cavalcanti, Ernesta
name: Sale, Silvia
name: Nicastro, Carmine
name: Atripaldi, Luigi
name: Starita, Noemy
name: Cerasuolo, Andrea
name: Reimer, Ulf
name: Holenya, Pavlo
name: Buonaguro, Luigi
name: Buonaguro, Franco M.
name: Tornesello, Maria Lina
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 11: Fig. S6. Antibodies reactivity against MERS and common-cold coronaviruses epitopes: adult serum samples (A) and children serum samples (B) with high reactivity against epitopes of different coronaviruses.
Supporting Aboriginal Community Controlled Health Services to deliver alcohol care: Protocol for a cluster randomised controlled trial
Creators: name: Harrison, KH
name: Lee, Kylie
name: Dobbins, T
name: Wilson, S
name: Hayman, N
name: Ivers, R
name: Haber, PS
name: Conigrave, JH
name: Johnson, D
name: Hummerston, B
name: Gray, D
name: Conigrave, K
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Introduction Indigenous peoples who have experienced colonisation or oppression can have a higher prevalence of alcohol-related harms. In Australia, Aboriginal Community Controlled Health Services (ACCHSs) offer culturally accessible care to Aboriginal and Torres Strait Islander (Indigenous) peoples. However there are many competing health, socioeconomic and cultural client needs. Methods and analysis A randomised cluster wait-control trial will test the effectiveness of a model of tailored and collaborative support for ACCHSs in increasing use of alcohol screening (with Alcohol Use Disorders Identification Test-Consumption (AUDIT-C)) and of treatment provision (brief intervention, counselling or relapse prevention medicines). Setting Twenty-two ACCHSs across Australia. Randomisation Services will be stratified by remoteness, then randomised into two groups. Half receive support soon after the trial starts (intervention or € early support'); half receive support 2 years later (wait-control or € late support'). The support Core support elements will be tailored to local needs and include: support to nominate two staff as champions for increasing alcohol care; a national training workshop and bimonthly teleconferences for service champions to share knowledge; onsite training, and bimonthly feedback on routinely collected data on screening and treatment provision. Outcomes and analysis Primary outcome is use of screening using AUDIT-C as routinely recorded on practice software. Secondary outcomes are recording of brief intervention, counselling, relapse prevention medicines; and blood pressure, gamma glutamyltransferase and HbA1c. Multi-level logistic regression will be used to test the effectiveness of support. Ethics and dissemination Ethical approval has been obtained from eight ethics committees: the Aboriginal Health and Medical Research Council of New South Wales (1217/16); Central Australian Human Research Ethics Committee (CA-17-2842); Northern Territory Department of Health and Menzies School of Health Research (2017-2737); Central Queensland Hospital and Health Service (17/QCQ/9); Far North Queensland (17/QCH/45-1143); Aboriginal Health Research Ethics Committee, South Australia (04-16-694); St Vincent's Hospital (Melbourne) Human Research Ethics Committee (LRR 036/17); and Western Australian Aboriginal Health Ethics Committee (779). Trial registration number ACTRN12618001892202; Pre-results.
Sub-word orthographic processing and semantic activation as revealed by ERPs
Creators: name: Hasenäcker, Jana
name: Nadalini, Andrea
name: Crepaldi, Davide
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Neuroscience
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: The present study investigated ERP signatures of processing sub-word orthography, that is, shorter words embedded within longer words, in a non-priming task that pushes for semantics. Participants performed a semantic categorisation task on pseudosuffixed and nonsuffixed words, like corner and peace, that contained embedded words (corn, pea) either congruent or not with the probe category (e.g. FOOD vs. ANIMAL). While the task required semantic activation of the whole-word, sub-word orthography and semantics were activated. Results indicate stronger negativity from as early as ∼230 ms after word onset when the embedded word did not fit the category, but only for pseudosuffixed words. The observed neural dynamics point to rapid extraction of sub-word orthography and prompt activation of meaning thereupon. We discuss the results with respect to literature on morphological processing, context-dependency of the mechanisms, and interpretations of the N250 and N400 components.
A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses
Creators: name: Wang, Pengfei
name: Casner, Ryan G.
name: Nair, Manoj S.
name: Yu, Jian
name: Guo, Yicheng
name: Wang, Maple
name: Chan, Jasper F.-W.
name: Cerutti, Gabriele
name: Iketani, Sho
name: Liu, Lihong
name: Sheng, Zizhang
name: Chen, Zhiwei
name: Yuen, Kwok-Yung
name: Kwong, Peter D.
name: Huang, Yaoxing
name: Shapiro, Lawrence
name: Ho, David D.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The repeated emergence of highly pathogenic human coronaviruses as well as their evolving variants highlight the need to develop potent and broad-spectrum antiviral therapeutics and vaccines. By screening monoclonal antibodies (mAbs) isolated from COVID-19-convalescent patients, we found one mAb, 2-36, with cross-neutralizing activity against SARS-CoV. We solved the cryo-EM structure of 2-36 in complex with SARS-CoV-2 or SARS-CoV spike, revealing a highly conserved epitope in the receptor-binding domain (RBD). Antibody 2-36 neutralized not only all current circulating SARS-CoV-2 variants and SARS-COV, but also a panel of bat and pangolin sarbecoviruses that can use human angiotensin-converting enzyme 2 (ACE2) as a receptor. We selected 2-36-escape viruses in vitro and confirmed that K378 T in SARS-CoV-2 RBD led to viral resistance. Taken together, 2-36 represents a strategic reserve drug candidate for the prevention and treatment of possible diseases caused by pre-emergent SARS-related coronaviruses. Its epitope defines a promising target for the development of a pan-sarbecovirus vaccine.
A CRISPR/Cas12a-based DNAzyme visualization system for rapid, non-electrically dependent detection of Bacillus anthracis
Creators: name: Wang, Dongshu
name: Chen, Gang
name: Lyu, Yufei
name: Feng, Erling
name: Zhu, Li
name: Pan, Chao
name: Zhang, Weicai
name: Liu, Xiankai
name: Wang, Hengliang
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: As next-generation pathogen detection methods, CRISPR-Cas-based detection methods can perform single-nucleotide polymorphism (SNP) level detection with high sensitivity and good specificity. They do not require any particular equipment, which opens up new possibilities for the accurate detection and identification of Bacillus anthracis. In this study, we developed a complete detection system for B. anthracis based on Cas12a. We used two chromosomally located SNP targets and two plasmid targets to identify B. anthracis with high accuracy. The CR5 target is completely new. The entire detection process can be completed within 90 min without electrical power and with single-copy level sensitivity. We also developed an unaided-eye visualization system based on G4-DNAzyme for use with our CRISPR-Cas12a detection system. This visualization system has good prospects for deployment in field-based point-of-care detection. We used the antisense nucleic acid CatG4R as the detection probe, which showed stronger resistance to interference from components of the solution. CatG4R can also be designed as an RNA molecule for adaptation to Cas13a detection, thereby broadening the scope of the detection system.
ESM1-studymap – Supplemental material for Development and psychometric validation of the interRAI ChYMH externalizing subscale
Creators: name: Lau, Chloe
name: Stewart, Shannon L
name: Saklofske, Donald H
name: Hirdes, John
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine

description: Supplemental material, ESM1-studymap for Development and psychometric validation of the interRAI ChYMH externalizing subscale by Chloe Lau, Shannon L Stewart, Donald H Saklofske and John Hirdes in Clinical Child Psychology and Psychiatry
Psychosocial Stressors and Maternal Mental Health in the U.S. During the First Wave of the COVID-19 Pandemic: A Cross-Sectional Analysis
Creators: name: Kochhar, Shivani
name: Mirzayi, Chloe
name: Nash, Denis
name: Parcesepe, Angela M.
name: Rane, Madhura S.
name: Maroko, Andrew R.
name: You, William
name: Zimba, Rebecca
name: Berry, Amanda
name: Westmoreland, Drew A.
name: Grov, Christian
name: Kulkarni, Sarah G.
Publisher: name: Springer Nature
Year: 2023

description:
Objectives The COVID pandemic has had widespread impacts on maternal mental health. This research aims to examine the relationship between psychosocial stressors and symptoms of depression and anxiety and the extent to which emotional support or resilient coping moderates the relationship between psychosocial stressors and maternal mental health during the first wave of the COVID pandemic. Methods This analysis includes data collected in October and November 2020 from a geographically and sociodemographically diverse sample of 776 mothers in the U.S. with children ≤ 18 years of age. Log binomial models were used to estimate the association between moderate or severe symptoms of anxiety and depression and psychosocial stressors. Results Symptoms of moderate or severe anxiety and depression were reported by 37.5% and 37.6% of participants, respectively. Moderate (aRR 2.76 [95% CI 1.87, 4.07]) and high (aRR 4.95 [95% CI 3.40, 7.20]) levels of perceived stress were associated with greater risk of moderate or severe anxiety symptoms. Moderate and high levels of parental burnout were also associated with greater prevalence of moderate or severe anxiety symptoms in multivariable models. Results were similar when examining the relationship among stress, parental burnout, and depressive symptoms. Neither resilient coping nor social support modified the relationship between psychosocial stressors and mental health. Conclusions for Practice Evidence-based strategies to reduce stress and parental burnout and improve the mental health of mothers are urgently needed. Strategies focused on bolstering coping and social support may be insufficient to improve maternal mental health during acute public health emergencies.
Supplemental_File1 – Supplemental material for Photoreceptor Degeneration in Homozygous Male Per2luc Mice During Aging
Creators: name: Varunika Goyal
name: DeVera, Christopher
name: Baba, Kenkichi
name: Sellers, Jana
name: Chrenek, Micah A.
name: P. Michael Iuvone
name: Tosini, Gianluca
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Neuroscience

description: Supplemental material, Supplemental_File1 for Photoreceptor Degeneration in Homozygous Male Per2luc Mice During Aging by Varunika Goyal, Christopher DeVera, Kenkichi Baba, Jana Sellers, Micah A. Chrenek, P. Michael Iuvone and Gianluca Tosini in Journal of Biological Rhythms
Gryposaurus monumentensis: the holotype fossil that brings people together
Creators: name: Jorgensen, Bailey
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Gryposaurus monumentensis: the holotype fossil that brings people together by Bailey Jorgensen of Raymond M. Alf Museum of Paleontology Claremont United States for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
QJE-STD-19-343_Supplemental_Tables – Supplemental material for Changes in the experience of time: The impact of spatial information on the perception and memory of duration
Creators: name: Fenerci, Can
name: Castanheira, Kevin Da Silva
name: LoParco, Myles
name: Signy Sheldon
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, QJE-STD-19-343_Supplemental_Tables for Changes in the experience of time: The impact of spatial information on the perception and memory of duration by Can Fenerci, Kevin da Silva Castanheira, Myles LoParco and Signy Sheldon in Quarterly Journal of Experimental Psychology