cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1: Figure S1. of In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation
Creators: name: Li, Jing
name: Wang, Bin
name: Kodali, Mahesh
name: Chen, Chao
name: Kim, Eunhee
name: Patters, Benjamin
name: Lan, Lubin
name: Kumar, Santosh
name: Wang, Xinjun
name: Yue, Junming
name: Liao, Francesca-Fang
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Increased cell number of microglia and astrocytes after intraperitoneally injected LPS. a and b Number of Iba1+ (a) and GFAP+ (b) cells in the hippocampal area between different treatments. c Number of the Iba1+ cells in the neocortical area between treatments. n = 5-8 per group. Data represent mean ± SEM; ns, no statistical significance, *P < 0.05, **P < 0.01, and ***P < 0.001. (PDF 18 kb)
Etude expérimentale à l’échelle locale de la coalescence de ponts capillaires dans les sols granulaires
Creators: name: El Korchi, F.Z.
name: Jamin, F.
name: El Youssoufi, M.S.
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: L'imbibition d’eau dans les matériaux granulaires induit des changements dans la morphologie des ponts capillaires qui passent d'une forme isolée (entre deux grains), à une forme fusionnée (entre plusieurs grains). Ces changements de morphologie de la phase liquide influencent le comportement mécanique et la résistance de ces matériaux. Dans cette communication, on propose une étude expérimentale de caractérisation du comportement mécanique et de la résistance d’un matériau granulaire dans le régime pendulaire et funiculaire à l'échelle locale. On s’intéresse en particulier à l’effet de l’imbibition et de la coalescence sur la force capillaire entre les grains solides. Les résultats obtenus à l’échelle locale semblent en accord avec le comportement connu des matériaux granulaires humides dans les régimes pendulaire et funiculaire, à l’échelle macroscopique.
description: Academic Journal of Civil Engineering, Vol 35 No 1 (2017): Special Issue - RUGC 2017 Nantes
Additional file 1: Figure S1. of A-to-I RNA editing in the rat brain is age-dependent, region-specific and sensitive to environmental stress across generations
Creators: name: Zaidan, Hiba
name: Ramaswami, Gokul
name: Golumbic, Yaela
name: Sher, Noa
name: Malik, Assaf
name: Barak, Michal
name: Galiani, Dalia
name: Dekel, Nava
name: Li, Jin
name: Gaisler-Salomon, Inna
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: A Flow chart of sample preparation using the Illumina-based Htr2c-direcetd NGS. (PDF 92 kb)
Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.
Creators: name: Kumpel, Belinda M
name: Saldova, Radka
name: Koeleman, Carolien A M
name: Abrahams, Jodie L
name: Ederveen, Agnes Hipgrave
name: Armour, Kathryn L
name: Olovnikova, Natalia I
name: Vidarsson, Gestur
name: Kapur, Rick
name: Rudd, Pauline M
name: Wuhrer, Manfred
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: Anti-D immunoglobulin (Anti-D Ig) prophylaxis prevents haemolytic disease of the fetus and newborn. Monoclonal IgG anti-Ds (mAb-Ds) would enable unlimited supplies but have differed in efficacy in FcγRIIIa-mediated ADCC assays and clinical trials. Structural variations of the oligosaccharide chains of mAb-Ds are hypothesised to be responsible. Quantitative data on 12 Fc-glycosylation features of 23 mAb-Ds (12 clones, 5 produced from multiple cell lines) and one blood donor-derived anti-D Ig were obtained by HPLC and mass spectrometry using 3 methods. Glycosylation of mAb-Ds from human B-lymphoblastoid cell lines (B) was similar to anti-D Ig although fucosylation varied, affecting ADCC activity. In vivo, two B mAb-Ds with 77-81% fucosylation cleared red cells and prevented D-immunisation but less effectively than anti-D Ig. High fucosylation (>89%) of mouse-human heterohybridoma (HH) and Chinese hamster ovary (CHO) mAb-Ds blocked ADCC and clearance. Rat YB2/0 mAb-Ds with <50% fucosylation mediated more efficient ADCC and clearance than anti-D Ig. Galactosylation of B mAb-Ds was 57-83% but 15-58% for rodent mAb-Ds. HH mAb-Ds had non-human sugars. These data reveal high galactosylation like anti-D Ig (>60%) together with lower fucosylation (<60%) as safe features of mAb-Ds for mediating rapid red cell clearance at low doses, to enable effective, inexpensive prophylaxis.
The role of photon recycling in perovskite light-emitting diodes.
Creators: name: Cho, Changsoon
name: Zhao, Baodan
name: Tainter, Gregory D
name: Lee, Jung-Yong
name: Friend, Richard H
name: Di, Dawei
name: Deschler, Felix
name: Greenham, Neil C
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: Perovskite light-emitting diodes have recently broken the 20% barrier for external quantum efficiency. These values cannot be explained with classical models for optical outcoupling. Here, we analyse the role of photon recycling (PR) in assisting light extraction from perovskite light-emitting diodes. Spatially-resolved photoluminescence and electroluminescence measurements combined with optical modelling show that repetitive re-absorption and re-emission of photons trapped in substrate and waveguide modes significantly enhance light extraction when the radiation efficiency is sufficiently high. In this manner, PR can contribute more than 70% to the overall emission, in agreement with recently-reported high efficiencies. While an outcoupling efficiency of 100% is theoretically possible with PR, parasitic absorption losses due to absorption from the electrodes are shown to limit practical efficiencies in current device architectures. To overcome the present limits, we propose a future configuration with a reduced injection electrode area to drive the efficiency toward 100%.
Emergent identity: a story of undoing and re-making professional identity in spaces of not knowing
Creators: name: Vella, Karen Frances
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The aim of this study is to explore the role of an emergent arts practice in the transformation of professional subjectivity for the organisational change manager. Beginning with the conventional literature of organisational change management, the researcher then turned to arts-based methods and feminist body theory in order to understand her own experience of confronting a crisis of confidence in mainstream management theory and practice. Through an auto-ethnographic investigation using fabric work and journal writing, the research focused on attending to the change manager’s body in art practice and organisational life. It documents the experience of not knowing entered through the process of fabric assemblage making and the struggle to articulate words in the liminal space of personal transformation and movement towards the production of new subjectivities and new knowledge. The study found that using creative processes of fabric object making enabled the conflicted body of the professional practitioner in crisis to emerge initially into abstract representation and ultimately to bridge the difficult transition into words. This transition represented an onto-epistemological transformation in which new knowledge came into being simultaneously with new forms of subjectivity. The research draws attention to the lived experience of change managers in organisations in confronting the deeper impacts of their work, and the need for an awareness of approaches to change work that take the body of the change manager into account. Through an exploration of the transformative power of sustained immersion in the language of the body, the study contributes to questions of enabling new subjectivities for the professional practitioner more generally.
Retrait empêché d’un matériau à base de terre crue.
Creators: name: Eid, Joanna
name: Kanema, Jean-Marc
name: Bulatovas, Gediminas
name: Bouchemella, Salima
name: Taibi, Said
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: Les éco-géomatériaux de construction à base de terre crue constituent une bonne alternative aux matériaux de construction classiques qui sont très énergivores en termes d’énergie grise. L’un des problèmes posé par ces matériaux à base de terre crue est leur aptitude accrue à la fissuration lors de la dessiccation. L’article présente une étude expérimentale permettant de quantifier les contraintes internes générées par le retrait de dessiccation, et qui sont à l’origine de l’apparition de la fissuration. Les résultats obtenus sur un béton de terre sont comparés à ceux d’un mortier de ciment classique, et mettent en évidence le comportement ductile, caractéristique des matériaux à base de terre crue.
description: Academic Journal of Civil Engineering, Vol 35 No 1 (2017): Special Issue - RUGC 2017 Nantes
Additional file 2: Figure S2. of In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation
Creators: name: Li, Jing
name: Wang, Bin
name: Kodali, Mahesh
name: Chen, Chao
name: Kim, Eunhee
name: Patters, Benjamin
name: Lan, Lubin
name: Kumar, Santosh
name: Wang, Xinjun
name: Yue, Junming
name: Liao, Francesca-Fang
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: The donor mice received either saline or 5 mg/kg of LPS injection and were kept alive for 24 h before blood collection. The recipient mice were iv. injected with the purified exosomes and kept alive for 24 h before being sacrificed. a Quantification of the relative immunofluorescent intensity of Iba1, GFAP, and S100 in the cortical area in Saline-Exo- and 5LPS24h-Exo-treated mouse brains. n = 3 per group. b Representative photomicrographs of the immunofluorescent staining in the brain sections from Saline-Exo- and 5LPS24h-Exo-treated mice. Anti-Iba1 antibody for microglia and anti-S100 antibodies for astrocytes (red), and DAPI for nuclei (blue). Scale bar: 50 μm. The white dotted boxes are zoom-in views of the corresponding photomicrographs, scale bar 5 μm. Data represent mean ± SEM; *P < 0.05. (PDF 87 kb)
OS EFEITOS ADVERSOS DOS INCENTIVOS FISCAIS
Creators: name: Gabriel Ulbrik Guerrera
name: José Marcos de Lira Oliveira Filho
Publisher: name: Zenodo
Year: 2023

description: RESUMO

O presente estudo, fundamentado em uma abordagem metodológica de pesquisa bibliográfica de natureza qualitativa e caráter descritivo, visa examinar os efeitos adversos resultantes da concessão de incentivos fiscais. Inicialmente, parte-se da análise da postura do Estado diante dos fenômenos econômicos, situando os incentivos fiscais como instrumentos de intervenção por indução, uma atuação que se efetiva por meio da aplicação da função extrafiscal da tributação. Em seguida, a pesquisa se dedica à investigação dos efeitos prejudiciais decorrentes das desonerações, incorporando o conceito de gasto tributário (tax expenditure) para evidenciar o impacto financeiro oriundo dessas renúncias fiscais. Ao final da análise, conclui-se que, embora os incentivos fiscais representem ferramentas importantes, sua concessão acarreta efeitos negativos que, com frequência, são negligenciados no momento da sua implementação. Esses efeitos devem ser cuidadosamente ponderados em relação aos benefícios reais advindos da política fiscal adotada.

 

Descritores: incentivos fiscais, efeitos adversos, gasto tributário, transparência, controle.
Regulation of building behaviour relating to nest space and transport in leaf-cutting ants
Creators: name: Bruce, Andrew Iain
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Ants build structures that facilitate the life of the colony. The structures are created in a highly variable environment by workers that lack centralised communication or a fixed plan. Instead, they use a system of self-organisation where each worker responds to local cues in such a way that a coherent structure emerges. How this process occurs can be both complex and specific to a species and therefore presents significant opportunity for study. One group of ants that creates particularly large, complicated, and sophisticated nests are the leaf-cutting ants. Leaf-cutting ants cut and carry leaf fragments, sometimes over great distances, and use them to grow a fungus garden that serves as a source of protein and nutrients for the colony's brood and adults. In this thesis I examine the regulation of nest construction in leaf-cutting ants: specifically construction of nest space and transport infrastructure, with a focus on nest tunnels and overhead clearance on foraging trails. A literature review places the nest construction behaviour of leaf-cutting ants into the context of the larger group to which they belong, fungus growing ants. It examines what is known and unknown about the construction mechanisms underlying the creation of tunnels, chambers and trails. Subsequently, I asked whether ants could regulate their digging rate in response to the tunnel space they initially encounter. Upon finding that they display higher excavation rates when presented with shorter tunnels than longer tunnels, I tested a prominent hypothesis that a 'digging pheromone' was a key component of the regulatory mechanism. The evidence suggested that it was not and that therefore a new understanding of digging regulation was required. In order to contribute to this new understanding I used the automated tracking system idTracker to follow the movement of ants as they extracted soil from a tunnel. This revealed the importance of interaction rate and arousal to the regulation of tunnel length and I integrated these factors into a conceptual model that could explain digging regulation. As a next step, I examined trail construction in leaf-cutting ants. The overhead method that leaf-cutting ants adopt in transporting leaves causes them to have an elevated clearance. If trails have overhanging obstacles, then the collision of the laden ants with these obstacles can slow their progress, requiring the removal of the obstructions for the sake of efficiency. I showed that the presence of laden ants on the trail is necessary for unladen ants to recognize the need to clear trails to a height suitable for laden ants. Furthermore, I showed that this mechanism is not triggered by the visual cue of an obstruction. These results show the importance of the dynamics of self-organised behaviour in creating large, sophisticated structures and point the way to understandings that could apply to industries as diverse as communication and micro-robotics.
On the carbon dynamics of Australian subalpine grasslands
Creators: name: McHugh, Ian David
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Grasslands in the alpine and subalpine tracts of the Australian southeast occupy a small area but store substantial quantities of soil carbon, which is likely to be affected as climate change shifts the balance between processes of ecosystem carbon import and export. In order to investigate the effects of differences in climate on carbon balance in subalpine grassland ecosystems, eddy covariance instrumentation was established at two climatologically contrasting sites during 2007/08: a cooler, wetter site that sustains winter snow cover (Dargo), and a warmer, drier site that does not (Nimmo). Both were substantial carbon sinks in 2007 and 2008; 93.0 and 111.4gC m ⁻² a ⁻¹ for Dargo, respectively, and 203.8 and 322.0gC m ⁻² a ⁻¹ for Nimmo. Differences in annual carbon uptake were mainly contributed by photosynthetic rather than respiratory fluxes, largely in association with temperature differences, which had two main effects. First, the retention of snow (and associated cessation of photosynthesis) reduced winter gross primary production (GPP) at Dargo. Second, since both sites showed effectively the same temperature-normalised bulk canopy photosynthetic response, GPP was generally lower at the cooler Dargo. Both sites were also subject to drought (severe regional drought conditions during 2006 continued into early 2007), resulting in the observed lower carbon uptake in 2007. The cross-year NEE difference was reduced at Dargo because increased GPP during the wetter summer of 2008 (also observed at Nimmo) was offset by decreased GPP during the cooler winter – and associated longer, later-lying snow season - of 2008. Since the co-occurrence of warm, dry or cool, wet conditions are characteristic of the dominant mode of regional climate variability, ENSO, this suggests that snow cover may moderate the interannual amplitude of NEE variability in these ecosystems. Superimposed on this, however, are expected longer-term changes in carbon storage. Consistent with globally observed soil carbon / climate relationships, soil carbon storage was almost 50% higher at Dargo (19.4kgC m ⁻² ) relative to Nimmo (13.4kgC m ⁻² ). On the basis of such relationships, warming and drying would be expected to result in reductions in soil carbon, particularly at Dargo, where the cool, moist conditions presently limit decomposition and thus maximise storage of labile soil carbon. While losses of soil carbon may be partially offset by the effects of warming on plant growth, both structural limitations on carbon sequestration in grassland vegetation and the slow expected rate of succession towards woody functional plant groups suggest that net carbon losses are likely in coming decades.
Additional file 1 of Assessing and improving public mental health literacy concerning rTMS
Creators: name: Morrison, Amanda S.
name: Uusberg, Andero
name: Ryan, Julia
name: Goldenberg, Amit
name: Etkin, Amit
name: Gross, James J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
Performances des bétons de chanvre : des propriétés microscopiques aux propriétés fonctionnelles
Creators: name: Delannoy, Guillaume
name: Marceau, Sandrine
name: Glé, Philippe
name: Gourlay, Etienne
name: Guéguen-Minerbe, Marielle1
name: Diafi, Dinarzed
name: Nour, Issam
name: Amziane, Sofiane
name: Farcas, Fabienne
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: Le béton de chanvre est un matériau biosourcé performant pour l’isolation des bâtiments. Il améliore aussi le confort au sein de l’habitat grâce à ses propriétés hygrothermiques et acoustiques. Le matériau est constitué de granulats végétaux très poreux (chènevotte) qui sont agglomérés à l’aide d’un liant minéral à base de chaux ou de ciment. Les performances d'isolation thermique et acoustique du béton de chanvre sont liées à sa porosité élevée. Dans cette étude, les relations entre les propriétés mesurées à différentes échelles sont présentées ainsi que l’impact du choix du type de liant. Pour cela, deux formulations « Mur » sont utilisées, avec une chènevotte et deux liants commerciaux : un liant formulé à base de chaux, et un ciment naturel. Le comportement thermique, hygroscopique et acoustique des deux bétons de chanvre est similaire, quelque soit le liant utilisé. Ces résultats sont expliqués par une porosité équivalente pour les deux formulations. Les résistances à la compression des deux formulations sont faibles, potentiellement dues à une inhibition des réactions d’hydratation des liants par les molécules extractibles dans l’eau de la chènevotte.
description: Academic Journal of Civil Engineering, Vol 35 No 1 (2017): Special Issue - RUGC 2017 Nantes
Additional file 3: Figure S3. of In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation
Creators: name: Li, Jing
name: Wang, Bin
name: Kodali, Mahesh
name: Chen, Chao
name: Kim, Eunhee
name: Patters, Benjamin
name: Lan, Lubin
name: Kumar, Santosh
name: Wang, Xinjun
name: Yue, Junming
name: Liao, Francesca-Fang
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Serum-derived exosomes isolated from HFD-fed mice increase microglial activation. a Photomicrographs of the hippocampal (Hp) and neocortical (Cx) areas from mice fed with either a chow diet or a HFD for 16 weeks. Brain sections were stained with anti-Iba1 antibody for microglia (red) and with DAPI for nuclei (blue). Scale bar: 50 μm. The white dotted boxes are zoom-in views of the corresponding photomicrographs, scale bar 10 μm. b and c Comparison of the relative immunofluorescent intensity of Iba1 in the hippocampal (b) and neocortical (c) area between two groups. n = 4-6 per group. d Average body weight of Chow-fed and HFD-fed mice before and after 16 weeks of feeding. n = 10 per group. e Photomicrographs of the hippocampal and neocortical areas from the recipient mice. Exosomes (1 mg in 200 μl PBS) isolated from the sera of Chow-fed or HFD-fed mice were injected intravenously to C57BL/6J mice. The recipient mice were euthanized 24 h after the injection. Brain sections were stained with anti-Iba1 antibody for microglia (red) and with DAPI for nuclei (blue). Scale bar: 20 μm. f and g Comparison of the relative immunofluorescent intensity of Iba1 in the hippocampal (f) and neocortical (g) area between two groups. n = 5 per group. Data represent mean ± SEM; *P < 0.05, ***P < 0.001. (PDF 178 kb)
99 problems: an exploration of writerly ontologies in transmedial life-writing
Creators: name: Maher, Laura-Jane
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Recent years have seen a proliferation of studies directed at storyworlds that are constructed across multiple media platforms. These are alternately described as transmedia, cross-media, and immersive or distributed phenomena. To date most research in this field has focussed on its implications for entertainment and imaginative storyworld creation, and has generally considered those storyworlds that blossom from cinematic or computer and consul gaming experiences. Rather than investigate the effect this constellation of artistic forms might have on the storyworld as a product, this thesis concentrates on the effect of using transmedial creative practices to explore autobiographical storyworlds, in particular how such storyworlds enable a renegotiation of the subject and other. The outcome of this research raises questions regarding how such storyworlds are positioned and regulated in an economic and legal context. To do this, this thesis draws on the semiotic theory of “writerlyness” and then embeds it within a feminist framework indebted to intersectionality to illuminate the matrix of ontologies that manifest in an autobiographical storyworld. Since the phenomenon involves both diegetic and mimetic modes, a new reading practice described as the “lacuna” is introduced to account for the variety of reading practices that arise in response to these storyworlds. This thesis considers how transmedial narratives are regulated and how that regulation is subverted in order to determine how readers and creators can use transmedial life-writing to challenge regulatory discourses that purport to police creative endeavour and subjective expression.
Additional file 4: Figure S4. of In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation
Creators: name: Li, Jing
name: Wang, Bin
name: Kodali, Mahesh
name: Chen, Chao
name: Kim, Eunhee
name: Patters, Benjamin
name: Lan, Lubin
name: Kumar, Santosh
name: Wang, Xinjun
name: Yue, Junming
name: Liao, Francesca-Fang
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: GFAP and S100 antibodies recognize the same cells in the hippocampus. Brain sections were stained with anti-GFAP antibody (green), with anti-S100 antibody (red), and with DAPI for nuclei (blue). Scale bar: 25Â Îźm. (PDF 88 kb)
Additional file 1 of Association between platelet, white blood cell count, platelet to white blood cell ratio and sarcopenia in community-dwelling older adults: focus on Bushehr Elderly Health (BEH) program
Creators: name: Gholizade, Mohamad
name: Farhadi, Akram
name: Marzban, Maryam
name: Mahmudpour, Mehdi
name: Nabipour, Iraj
name: Kalantarhormozi, Mohammadreza
name: Shafiee, Gita
name: Ostovar, Afshin
name: Larijani, Bagher
name: Darabi, Amir Hossein
name: Safavi, Eisa
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 1: Supplementary 1. Characteristics of previous studies worked on sarcopenia and inflammatory marker.
Effects of mitochondrial genomic variation on life history trait expression in Drosophila melanogaster
Creators: name: Camus, Maria Florencia
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The mitochondria are essential for life in eukaryotes, taking centre-stage in the process of cellular respiration. This process is regulated via a series of finely coordinated interactions encoded by two obligate genomes – nuclear and mitochondrial. Both genomes are required for the production of cellular energy, and thus their harmonious interaction is vital for the maintenance of mitochondrial integrity and the viability of eukaryote life. Recently many studies have shown an abundance of phenotype-changing genetic variation segregating within the mtDNA genome – and these results run counter to the traditional paradigm in which mitochondrial genetic variation was expected to be evolving neutrally. It remains unclear how this variation is accumulating – either adaptively under selection, or non-adaptively under mutation-selection balance. Furthermore, maternal inheritance of the mitochondrial genome predisposes this genome to accumulation of mutations that have male biased effect, and the existence of these male-harming mutations has recently been empirically substantiated. The aim of my thesis is to explore and elucidate the nature of the evolutionary processes that shape the molecular composition of the mitochondrial genome. My goal was to understand how much of the genetic variance accumulating within the genome is sex-specific, and in particular male-biased. This would support the idea that mitochondrial variation consisted largely of deleterious mutation loads that accumulate under maternal transmission. Secondly I was interested in understanding how much genetic variation is adaptive – occurring in both sexes, and exhibiting phenotypic responses to thermal stresses that concord with expected predictions based on where the mtDNA haplotypes have evolved. Finally, I aimed to elucidate the molecular mechanisms that bridge the link between mitochondrial genotype and phenotype.
Can Users Detect Biases or Factual Errors in Generated Responses in Conversational Information-Seeking?
Creators: name: Łajewska, Weronika
name: Balog, Krisztian
name: Spina, Damiano
name: Trippas, Johanne
Publisher: name: arXiv
Year: 2024
Subjects: subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: Information-seeking dialogues span a wide range of questions, from simple factoid to complex queries that require exploring multiple facets and viewpoints. When performing exploratory searches in unfamiliar domains, users may lack background knowledge and struggle to verify the system-provided information, making them vulnerable to misinformation. We investigate the limitations of response generation in conversational information-seeking systems, highlighting potential inaccuracies, pitfalls, and biases in the responses. The study addresses the problem of query answerability and the challenge of response incompleteness. Our user studies explore how these issues impact user experience, focusing on users' ability to identify biased, incorrect, or incomplete responses. We design two crowdsourcing tasks to assess user experience with different system response variants, highlighting critical issues to be addressed in future conversational information-seeking research. Our analysis reveals that it is easier for users to detect response incompleteness than query answerability and user satisfaction is mostly associated with response diversity, not factual correctness.
description: Extended version of the paper that appeared in the Proceedings of the 2024 Annual International ACM SIGIR Conference on Research and Development in Information Retrieval in the Asia Pacific Region (SIGIR-AP '24)
Additional file 1 of Interprofessional care of patients with type 2 diabetes mellitus in primary care: family physicians’ perspectives
Creators: name: Torti, Jacqueline M. I.
name: Szafran, Olga
name: Kennett, Sandra L.
name: Bell, Neil R.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file1:
Histone mediated transduction for gene therapy and novel reverse transfection cell microarrays based on aminomalononitrile self-polymerisation chemistry
Creators: name: Nastasie, Michael
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Our understanding of the link between gene function and disease is constantly strengthening however gene therapy is currently limited by a lack of safe, efficient and specific vectors for DNA delivery. Histone mediated transduction (HMT) is a promising, efficient non-viral DNA delivery technique utilising histone proteins as non-toxic DNA vectors. The tumour cell enhanced nuclear targeting signal (tNTS) of the Apoptin protein has been fused to histones in Chapter 2 to create novel recombinant histone proteins that specifically accumulate in the nucleus of cancer cells. Nuclear accumulation was characterised in a breast tumour progression model, demonstrating that the tNTS has increased specificity for the latter stages of tumour progression. This study also identified an affinity of histone proteins for cancer cells, leading to recombinant proteins with a >13-fold specificity for cancer cell nuclei, with important implications for future cancer specific gene therapy approaches. Reverse Transfection Cell Microarray (RTCM) technology is designed for the simultaneous high throughput analysis of numerous genes in a live cell format and promises to revolutionise data collection from tissue culture cell lines. RTCM technology however is limited by inefficient transfection and the lack of a simple, efficient and inexpensive 2D cell surface patterning system. These surfaces only allow cells to attach to spots containing arrayed genetic material, facilitating automated analysis and reducing cross-contamination, thereby enhancing the efficiency of the array. Chapter 3 addresses the synthesis and optimisation of a novel, inexpensive and simple 2D cell surface patterning system based on aminomalononitrile (AMN) chemistry. An activated AMN solution was spotted onto a non-fouling (bio-resistant) poly(hydroxyethyl methacrylate) (pHEMA) background, limiting cell attachment to areas where AMN polymer is present. Chapter 4 investigates the addition of positively charged copolymers to the activated AMN and further optimises the transfection solution while chapter 5 investigates histone octamer and tetramer based reverse transfection on RTCMs for the first time. The result is a pHEMA-AMN-5% poly(allylamine) 2D patterned surface that is simpler to produce than any previously described, offering significant advantages over current RTCM technology. HMT was found to provide a benefit to RTCMs utilising Lipofectamine 2000 transfection, with implications for RTCMs utilising that reagent. Due to the simplicity and customisability of the AMN chemistry demonstrated, the 2D surface patterning system generated in this thesis is poised to make a significant contribution to the high-throughput screening of genetic material, drugs and other biomolecules in live cells, facilitating the progress of numerous scientific fields.
ELIXIR - Cellular and Molecular Research - Strategy
Creators: name: Aloy, Patrick
name: Psomopoulos, Fotis
name: Tosatto, Silvio
name: Anton, Mihail
name: Liberante, Fabio
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Molecular biology
subject: Cell biology
subject: Computational Biology
subject: Multiomics
subject: Artificial intelligence
subject: Machine learning
subject: Data Management
subject: Europe
subject: Intersectoral Collaboration
subject: Capacity Building
subject: FAIR Data Principles
subject: Data Integration
subject: Research Infrastructure
subject: Open Science
subject: Interoperability
subject: Life Sciences
subject: Science Collaboration

description: This document describes ELIXIR’s Strategy for developing the Cellular and Molecular Research (CMR) Priority Area within the Science Tier of the ELIXIR Scientific Programme 2024-2028. It has been developed by the CMR Priority Area leads, with support from the ELIXIR Hub, and with contributions and feedback from ELIXIR members across Nodes, Communities, Focus Groups, and Platforms.

The Strategy outlines key challenges facing cellular and molecular research including overcoming data silos, promoting FAIR data principles and leveraging AI and machine learning to enhance data analysis and interpretation. The overarching aims of the CMR Priority Area are articulated through a clear vision and mission, focusing on integrating diverse datasets, advancing computational tools, and supporting multi-omics and multimodal research communities. Finally, the Strategy summarises the practical steps of its implementation and growth as a cohesive ecosystem for cellular and molecular research, driving innovation.
title: OFROM: interview avec unine15z04m
Creators: name: Delafontaine, François
name: , Brun
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.8d139d36.v2#c733aacae6052e030bf43b19a3b06b4165254fe2
MOESM1 of Microbial community response reveals underlying mechanism of industrial-scale manganese sand biofilters used for the simultaneous removal of iron, manganese and ammonia from groundwater
Creators: name: Zhang, Yu
name: Sun, Rui
name: Zhou, Aijuan
name: Zhang, Jiaguang
name: Luan, Yunbo
name: Jia, Jianna
name: Yue, Xiuping
name: Zhang, Jie
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: Additional file 1. Additional figures and tables.
L’effet du laitier de haut fourneau sur la porosité du mortier
Creators: name: DEBOUCHA, W.
name: LEKLOU, N.
name: KHELIDJ, A.
name: PERTUE, A.
name: OUDJIT, M.N.
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: La réduction de la pollution de l’environnement est devenue aujourd’hui un aspect important qui doit être pris en considération lors de la fabrication de béton. Par conséquent, l’utilisation des ajouts minéraux permettra d’obtenir l’aspect économique et écologique souhaité.L’objectif de cette étude est d’analyser l’évolution de la porosité totale et capillaire d’un mortier en substituant 20%, 30%, et 40% de ciment par du laitier de haut fourneau. Les résultats obtenus ont montré que la porosité totale avec ajout de laitierest plus ou moins similaire à celle du mortier sans ajout, alors que l’absorption capillaireestlimitée dans le cas du mortieravec ajout de laitier.
description: Academic Journal of Civil Engineering, Vol 35 No 1 (2017): Special Issue - RUGC 2017 Nantes
Developing approaches to jazz composition and improvisation informed by the dissonant counterpoint methods of Charles Seeger and Ruth Crawford
Creators: name: O'Connor, Joseph
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: This project investigates how Ruth Crawford’s applications of concepts from Charles Seeger’s Manual of Dissonant Counterpoint can inform non-tonal jazz improvisation and composition. Crawford and Seeger’s collaboration between 1929 and 1931 culminated in a distinctive compositional approach called dissonant counterpoint that was founded on a dialectic between the traditions of Western concert music, and experimentation with various types of dissonance. This commentary argues that innovation in jazz emerges from a similar dialectic between convention and experimentation, which is enriched by practices extrinsic to the jazz tradition. I have developed a collection of recordings for solo piano and piano trio that embody various syntheses of dissonant counterpoint and jazz. Following a critique of mainstream jazz practices, I refer to Crawford and Seeger’s discourse to advances two primary aims: Firstly, to develop distinctive approaches to non- tonal pitch organisation suitable for both composition and improvisation; and secondly, to develop templates for improvisation (called referents) that encourage sophisticated, contrapuntal musical textures. Each type of referent discussed in this commentary requires the performer to engage with the construction of reference materials while they improvise. Rather than relating to chord progressions that are unchanged during multiple repetitions (solo choruses), improvisers are provided with multilayered reference information that can be configured in a variety of ways. Some compositions provide independent, contrasting harmonic streams that are synthesised and juxtaposed by the performer as they improvise. Some referents supply metrical and rhythmic information that co-ordinates multilayered improvisations. Other compositions supply sets of modules that are sequenced, combined and varied by the improviser. Each referent engenders textural sophistication by embedding a concept of counterpoint within the information that performers relate as they improvise. I conclude by considering ways that my assimilation of modernist techniques reveals a metamodern sensibility, an emergent trend identified by cultural theorists Velmeulen and Van Den Akker. Additional material(s) submitted with thesis.
Analysing one- and two-bit data to reduce memory requirements for F-statistic-based gravitational wave searches
Creators: name: Clearwater, Patrick
name: Melatos, Andrew
name: Nepal, Surya
name: Bailes, Matthew
Publisher: name: arXiv
Year: 2024
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Searches for continuous-wave gravitational radiation in data collected by modern long-baseline interferometers, such as the Laser Interferometer Gravitational-wave Observatory (LIGO), the Virgo interferometer and the Kamioka Gravitational Wave Detector (KAGRA), can be memory intensive. A digitisation scheme is described that reduces the 64-bit interferometer output to a one- or two-bit data stream while minimising distortion and achieving considerable reduction in storage and input/output cost. For the representative example of the coherent, maximum-likelihood matched filter known as the F-statistic, it is found using Monte-Carlo simulations that the injected signal only needs to be ~24 per cent stronger (for one-bit data) and ~6.4 per cent stronger (for two bit data with optimal thresholds) than a 64-bit signal in order to be detected with 90 per cent probability in Gaussian noise. The foregoing percentages do not change significantly when the signal frequency decreases secularly, or when the noise statistics are not Gaussian, as verified with LIGO Science Run 6 data.
description: 17 pages, 6 figures; accepted for publication in Astrophysical Journal
Non-parametric reconstruction of the fine structure constant with galaxy clusters
Creators: name: Ferreira, Marcelo
name: Holanda, Rodrigo F. L.
name: Gonzalez, Javier E.
name: Colaço, L. R.
name: Nunes, Rafael C.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Testing possible variations in fundamental constants of nature is a crucial endeavor in observational cosmology. This paper investigates potential cosmological variations in the fine structure constant ($α$) through a non-parametric approach, using galaxy cluster observations as the primary cosmological probe. We employ two methodologies based on galaxy cluster gas mass fraction measurements derived from X-ray and Sunyaev-Zeldovich observations, along with luminosity distances from type Ia supernovae. We also explore how different values of the Hubble constant ($H_0$) impact the variation of $α$ across cosmic history. When using the Planck satellite's $H_0$ observations, a constant $α$ is ruled out at approximately the 3$σ$ confidence level for $z \lesssim 0.5$. Conversely, employing local estimates of $H_0$ restores agreement with a constant $α$.
description: 10 pages, 3 figures, I table. Accepted by the The European Physical Journal C
Water Management in Jordan and its Impact on Water Scarcity
Creators: name: Al Omari, Hanan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: Jordan
Water Scarcity
Water Management
Challanges

description: Jordan is among the poorest countries in the world with respect to water resources. Water scarcity in Jordan is an alarming problem that can jeopardize the economy and the stability of the country. It is a multidimensional problem caused by many factors such as the fluctuation of annual precipitation rates, the rapid change in population caused by the refugee influx from neighbouring countries, and the economic situation of the country. The water scarcity problem is aggravated by limitations in water management. This research investigated the shortcomings of water management that contribute to water scarcity. It involves a literature review, a survey questionnaire and interviews. These methods aim to assess the current challenges that prompt water scarcity, understand the water management shortcomings and their causes, identify the existing government solutions for water scarcity, and propose a sustainable solution for this problem. The research finds that water management in Jordan has several shortcomings such as the lack of monitoring and controlling water resources and preventing illegal drilling, the incapability of the government to reduce the non-revenue water as a result of aged water network and water theft, and illegal practices of the agricultural and industrial sectors. This research proposed a solution that aim to mitigate water scarcity in Jordan by enhancing several management practices. Moreover, the proposed solution calls for efficient managerial practices to be adopted by decision makers and the public. I argue that the proposed solutions are sustainable and cheaper than the existing government solutions that rely on searching for new water resources rather than improving water management.
Effectiveness of exercise intervention on physical and health outcomes in patients admitted to an acute medical ward: A systematic review and meta-analysis
Creators: name: McCaig, Jane
name: Gordon, Brett
name: Taylor, Carolyn
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 4203
subject: Health services and systems
classificationCode: 420501
subject: Acute care
classificationCode: 4207
subject: Sports science and exercise
classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 4206
subject: Public health
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 3202
subject: Clinical sciences

description: Objective: To evaluate the effectiveness of inpatient medical ward exercise on physical and health outcomes in adults compared with usual care. Data sources: Medline, CINAHL and EMBASE were searched from inception to 20 April 2023. Review methods: Randomised-controlled trials in English that reported physical and health outcomes of adults who received an exercise intervention on an acute medical ward were included. Two reviewers independently extracted data. Methodological quality was assessed using the PEDro and TESTEX scales. The GRADE rating assessed the quality of evidence to evaluate the certainty of effect. Meta-analyses were performed where possible. Results: Thirteen studies were included, with 1273 unique participants (mean [SD] age, 75.5 [11] years), which compared exercise intervention with usual care. Low quality evidence demonstrated a significant improvement in aerobic capacity ([MD], 1.39 m [95% CI, 0.23, 2.55], p = 0.02) and maximum isometric strength ([MD], 2.3 kg [95% CI, 2.2, 2.4], p < 0.001) for the exercise intervention compared with usual care. Low quality evidence demonstrated no difference for in-hospital falls count ([OR], 1.93 [95% CI, 0.61, 6.12] p = 0.27) or mortality ([OR], 0.77 [95% CI, 0.48, 1.23], p = 0.27). Moderate quality evidence demonstrated no difference for length of stay ([MD], −0.10 days [95% CI, −0.31, 0.11] p = 0.36). Conclusion: Exercise prescribed during an acute medical ward stay improves aerobic capacity and maximum isometric strength but may not reduce length of stay, in-hospital falls or mortality.