cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Isolation of amylase regulators from the leaves of Ixeridium dentatum
Creators: name: Park, SeonJu
name: Nhiem, Nguyen Xuan
name: Park, Jun Hyung
name: Bhattarai, Kashi Raj
name: Chae, Han-Jung
name: Kim, Hyung-Ryong
name: Kim, Seung Hyun
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Virology

description: Two new compounds, one sesquiterpene lactone (1) and one phenylethanoid tautomer (2), together with eleven known compounds (3–13) were isolated from the leaves of Ixeridium dentatum. Their structures were determined by extensive spectroscopic methods, including 1D-, 2D-NMR, and mass spectrometry. All compounds were evaluated for their amylase secretion activity in human salivary gland cells after treatment in 40 mM of high glucose. All compounds showed increased amylase secretion activity. Moreover, previously undescribed compounds (1–2), luteolin 7-O-β-D-glucopyranoside (10), quercimeritrin (11), and quercetin 3-O-β-D-xylopyranoside (13) exhibited significant amylase activity, which is comparable to the positive control.
Recursion for the smallest eigenvalue density of $β$-Wishart-Laguerre ensemble
Creators: name: Kumar, Santosh
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mathematical Physics (math-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Applications (stat.AP)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: 15B52, 15A18, 65Q30, 81Q50, 33C70, 60F10, 81V65

description: The statistics of the smallest eigenvalue of Wishart-Laguerre ensemble is important from several perspectives. The smallest eigenvalue density is typically expressible in terms of determinants or Pfaffians. These results are of utmost significance in understanding the spectral behavior of Wishart-Laguerre ensembles and, among other things, unveil the underlying universality aspects in the asymptotic limits. However, obtaining exact and explicit expressions by expanding determinants or Pfaffians becomes impractical if large dimension matrices are involved. For the real matrices ($β=1$) Edelman has provided an efficient recurrence scheme to work out exact and explicit results for the smallest eigenvalue density which does not involve determinants or matrices. Very recently, an analogous recurrence scheme has been obtained for the complex matrices ($β=2$). In the present work we extend this to $β$-Wishart-Laguerre ensembles for the case when exponent $α$ in the associated Laguerre weight function, $λ^αe^{-βλ/2}$, is a non-negative integer, while $β$ is positive real. This also gives access to the smallest eigenvalue density of fixed trace $β$-Wishart-Laguerre ensemble, as well as moments for both cases. Moreover, comparison with earlier results for the smallest eigenvalue density in terms of certain hypergeometric function of matrix argument results in an effective way of evaluating these explicitly. Exact evaluations for large values of $n$ (the matrix dimension) and $α$ also enable us to compare with Tracy-Widom density and large deviation results of Katzav and Castillo. We also use our result to obtain the density of the largest of the proper delay times which are eigenvalues of the Wigner-Smith matrix and are relevant to the problem of quantum chaotic scattering.
description: Published version
Evaluation of antidiabetic activity of Morus nigra L. and Bauhinia variegata L. leaves as Egyptian remedies used for the treatment of diabetes
Creators: name: Hago, Salma
name: Mahrous, Engy A.
name: Moawad, Mohamed
name: Abdel-Wahab, Samia
name: Abdel-Sattar, Essam
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Virology

description: Morus nigra and Bauhinia variegata are used in the Egyptian folk medicine for their hypoglycemic effects. The standardized ethanolic extracts of both plants caused a significant decrease in fasting blood glucose level at two different doses (250 and 500 mg/kg) in streptozotocin-induced diabetic rats' model. Further, in vitro antioxidant activity and α-glucosidase inhibition assays were conducted as well as the measurement of insulin levels and the biomarkers for both liver and kidney functions in the treated animals. Beneficiary effects of BMLE and BVLE in the treatment of diabetes were found not to be limited to hypoglycemic effect but included preventing liver and kidney tissue damage that are associated with diabetes. A strong inhibition of the α-glucosidase enzyme by both extracts may be a contributing mechanism in the overall anti-diabetic effect that was observed. Further detailed study is needed in the future to explore the mechanism of action of both plants.
The smallest singular value of a shifted $d$-regular random square matrix
Creators: name: Litvak, Alexander
name: Lytova, Anna
name: Tikhomirov, Konstantin
name: Tomczak-Jaegermann, Nicole
name: Youssef, Pierre
Publisher: name: arXiv
Year: 2017
Subjects: subject: Probability (math.PR)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 60B20, 15B52, 46B06, 05C80

description: We derive a lower bound on the smallest singular value of a random $d$-regular matrix, that is, the adjacency matrix of a random $d$-regular directed graph. More precisely, let $C_1
MOESM2 of Cooperation of hydrolysis modes among xylanases reveals the mechanism of hemicellulose hydrolysis by Penicillium chrysogenum P33
Creators: name: Yang, Yi
name: Yang, Jinshui
name: Wang, Ruonan
name: Liu, Jiawen
name: Zhang, Yu
name: Liu, Liang
name: Wang, Fengqin
name: Yuan, Hongli
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Computational Biology

description: Additional file 2: Table S2. The degree of synergism between different xylanases.
Promalabaricone B from Myristica fatua Houtt. seeds demonstrate antidiabetic potential by modulating glucose uptake via the upregulation of AMPK in L6 myotubes
Creators: name: Prabha, B.
name: Sini, S.
name: Sherin, D. R.
name: Neethu, S.
name: Rameshkumar, K. B.
name: Manojkumar, T. K.
name: Jayamurthy, P.
name: Radhakrishnan, K. V.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Promalabaricone B (PMB), an acylphenol was isolated from dichloromethane-soluble extract of the seeds of Myrisitica fatua Houtt. PMB exhibited significant inhibitory activity on α-glucosidase enzyme. The molecular docking and dynamics studies of PMB with human maltase-glucoamylase were performed. PMB exhibited an enhanced glucose uptake in L6 myotubes with 46.3% in 2.5 µM. Encouraged with these results; we investigated the molecular mechanism of PMB through the upregulation of AMPK. The results revealed that PMB promoted the glucose uptake in myocytes by stimulating the translocation and expression of GLUT4. From this, it is clear that PMB can acts as a potential therapeutic option for diabetes treatment, and its hypoglycaemic effect may be mediated by AMPK upregulation and induction of GLUT4 translocation.
First report of spiro-compounds from marine macroalga Gracilaria salicornia: prospective natural anti-inflammatory agents attenuate 5-lipoxygenase and cyclooxygenase-2
Creators: name: Chakraborty, Kajal
name: Antony, Tima
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer

description: The inflammation pathology is an orchestrated biological process and the dual inhibition of pro-inflammatory enzymes 5-lipoxygenase and cyclooxygenase-2 has been found to be an effective approach against inflammation. This study involves the characterisation of two previously undescribed spiro[5.5]undecanes, 3-(hydroxymethyl)-7-(methoxymethyl)-3,11-dimethyl-9-oxospiro[5.5]undec-4-en-10-methylbutanoate (1) and 4-ethoxy-11,11-dimethyl-7-methylene-8-(propionyloxy)spiro[5.5]undec-2-en-104,106-dihydroxytetrahydro-2H-pyran-10-carboxylate (2) with potential anti-inflammatory properties, from seaweed Gracilaria salicornia by extensive-spectroscopic-experiments. These metabolites recorded prospective bioactivities against 5-lipoxygenase (IC50 < 2.80 mM), whereas their selectivity indices were significantly greater (∼1) than ibuprofen (0.89) (p < 0.05), which attributed selective anti-inflammatory potencies of the studied spiro[5.5]undecane derivatives against inducible cyclooxygenase-2 than constitutive cyclooxygenase-1. Radical scavenging potential of spiro[5.5]undec-2-en-104,106-dihydroxytetrahydro-2H-pyran-10-carboxylate analogue (2) against oxidants, 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis-3 ethylbenzothiozoline-6-sulfonic acid were found to be greater (IC50 < 1.25 mM) than commercial standard, α-tocopherol (IC50 1.42–1.79 mM). The greater hydrogen-bonding interactions and binding affinity of 2 (−10.13 kcal/mol) with 5-LOX appropriately corroborated its prospective anti-inflammatory activity.
Additional file 1 of Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS
Creators: name: Morales-Quinteros, Luis
name: Neto, Ary Serpa
name: Artigas, Antonio
name: Blanch, Lluis
name: Botta, Michela
name: Kaufman, David A.
name: Schultz, Marcus J.
name: Tsonas, Anissa M.
name: Paulus, Frederique
name: Bos, Lieuwe D.
Publisher: name: figshare
Year: 2021
Subjects: Medicine
Cell Biology
Biotechnology
Biological Sciences not elsewhere classified
Science Policy
Computational Biology

description: Additional file 1. Impaired ventilation is not associated with 28-day mortality in COVID-19 ARDS
The Other Fermion Compositeness
Creators: name: Bellazzini, Brando
name: Riva, Francesco
name: Serra, Javi
name: Sgarlata, Francesco
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss the only two viable realizations of fermion compositeness described by a calculable relativistic effective field theory consistent with unitarity, crossing symmetry and analyticity: chiral-compositeness vs goldstino-compositeness. We construct the effective theory of $\mathcal{N}$ Goldstini and show how the Standard Model can emerge from this dynamics. We present new bounds on either type of compositeness, for quarks and leptons, using dilepton searches at LEP, dijets at the LHC, as well as low-energy observables and precision measurements. Remarkably, a scale of compositeness for Goldstino-like electrons in the 2 TeV range is compatible with present data, and so are Goldstino-like first generation quarks with a compositeness scale in the 10 TeV range. Moreover, assuming maximal $R$-symmetry, goldstino-compositeness of both right- and left-handed quarks predicts exotic spin-1/2 colored sextet particles that are potentially within the reach of the LHC.
description: 32 pages on how Thomson might have discovered supersymmetry; v2: few typos fixed and comments added
New derivatives of 11-keto-β-boswellic acid (KBA) induce apoptosis in breast and prostate cancers cells
Creators: name: Araba, Asma Bani
name: Rehman, Najeeb Ur
name: Al-Araimi, Amna
name: Al-Hashmi, Sulaiman
name: Al-Shidhani, Sulaiman
name: Csuk, Rene
name: Hussain, Hidayat
name: Al-Harrasi, Ahmed
name: Zadjali, Fahad
Publisher: name: Taylor & Francis
Year: 2019
Subjects: Biochemistry
Space Science
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology

description: A series of new 11-keto-β-boswellic acid were partially-synthesized by modifying the hydroxyl and carboxylic acid functional groups of ring A. The structures of the new analogs were confirmed by detailed spectral data analysis. Compounds 4, 5 and 9 exhibited potent anti-cancer results against two human tumor cancer cell lines having IC50 value of MCF-7 (breast) and LNCaP (prostate): 123.6, 9.6 and 88.94 μM and 9.6, 44.12 and 12.03 μM, respectively. Additionally, a maximum nuclear fragmentation was observed for 4 (78.44%) in AKBA treated cells after 24 hr followed by 5 and 9 with (74.25 and 66.9% respectively). This study suggests that the presence of hydrazone functionality (4 and 9) has effectively improved the potency of AKBA. Interestingly, compound 5 with a lost carboxylic acid group of ring A showed comparable potent activity. Highly selective AKBA requires further modification to improve its bioavailability and solubility inside the cancer cells.
Slowing down of charged particles in dusty plasmas with pawer-law kappa-distributions
Creators: name: Du, Jiulin
name: Guo, Ran
name: Liu, Zhipeng
name: Du, Songtao
Publisher: name: arXiv
Year: 2017
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: We study the slowing down of particle beams passing through the dusty plasma with power-law kappa-distributions. Three plasma components, electrons, ions and dust particles, can have different kappa-parameter. We derive the deceleration factor (the velocity moment equation) and the slowing down time of a test particle, and numerically study the slowing down properties of an electron beam, a proton beam and a dust particle beam, respectively, in the kappa-distributed dusty plasma. We show that the slowing down properties of particle beams depend strongly on the kappa-parameters of the plasma components, and the dust component plays a dominant role in the slowing down. And the slowing down also depends on mass and charge of the dust particles in the dusty plasma. More detailed results are shown in 17 numerical graphs.
description: 15 pages,7 figures, 1 table
title: ADCO, Cartulaire de Fontenay, second fragment (XIIIe siècle), Cart. 201 (15 H 9), folios 47-142, f. 015r
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2009
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cartulaire de Fontenay, second fragment (XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 201 (15 H 9), folios 47-142. Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Fontenay, second fragment (XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 201 (15 H 9), folios 47-142, f. 015r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Fontenay
description: Provenance: http://www.wikidata.org/entity/Q464918
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb119679755
description: Provenance: https://www.geonames.org/7874015
description: Provenance: http://www.idref.fr/027691802/id
Assessment of chemically characterized Salvia sclarea L. essential oil and its combination with linalyl acetate as novel plant based antifungal, antiaflatoxigenic and antioxidant agent against herbal drugs contamination and probable mode of action
Creators: name: Kumar Singh, Vipin
name: Das, Somenath
name: Dwivedy, Abhishek Kumar
name: Chaudhari, Anand Kumar
name: Upadhyay, Neha
name: Dubey, Nawal Kishore
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: The present investigation reports antifungal and antiaflatoxigenic efficacy of Salvia sclarea essential oil (SSEO) and its combination with Linalyl acetate (LA) (1:1) against herbal drug deteriorating molds and aflatoxin B1 contamination. GC-MS analysis of SSEO showed Linalyl Acetate (LA) (61.33%) and Linalool (LL) (17.59%) as major components. The SSEO and LA combination displayed better antifungal and antiaflatoxigenic activity as compared to SSEO and LA used individually. SSEO and LA combination was effective in reduction of ergosterol and enhanced leakage of vital ions and UV-absorbing materials in a dose dependent manner. The combination caused significant reduction in cellular methylglyoxal content, an aflatoxin inducer suggesting its future application for development of aflatoxin resistant herbal drug varieties through green transgenics. The combination also showed pronounced antioxidant activity as compared to SSEO and LA used separately. Interestingly, the combination showed significant in situ protection of Picrorhiza kurroa rhizomes against mould infestation.
Tetrachaetum elegans Ingold, Trans.
Creators: name: Tibell, Sanja
name: Tibell, Leif
name: Pang, Ka-Lai
name: Jones, E. B. Gareth
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Fungi
Ascomycota
Leotiomycetes
Helotiales
Discinellaceae
Tetrachaetum
Tetrachaetum elegans

description: 69. Tetrachaetum elegans Ingold, Trans. Br. mycol. Soc. 25(4): 381 (1942) [1941]
  Substrate and distribution: Furcellaria lumbricalis.  Västergötland.
 Notes: Reported by Erneholm (1972). Originally described from decaying leaves in freshwater.
description: Published as part of Tibell, Sanja, Tibell, Leif, Pang, Ka-Lai & Jones, E. B. Gareth, 2020, A conspectus of the filamentous marine fungi of Sweden, pp. 141-153 in Botanica Marina (Warsaw, Poland) (Warsaw, Poland) 63 (2) on page 150, DOI: 10.1515/bot-2018-0114, http://zenodo.org/record/11360145
Trichoderma citrinoviride Bissett, Can. J. Bot.
Creators: name: Tibell, Sanja
name: Tibell, Leif
name: Pang, Ka-Lai
name: Jones, E. B. Gareth
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Fungi
Ascomycota
Sordariomycetes
Hypocreales
Hypocreaceae
Trichoderma
Trichoderma citrinoviride

description: 73.  Trichoderma citrinoviride Bissett , Can. J. Bot. 62(5): 926 (1984)
 Substrate and distribution: Marine wood. Bohuslän. New to Sweden.
 Notes: An ITS sequence from culturing (Isol. ST16): GenBank MN058992. was identified by sequence comparison; Length = 534, Score (Bits) 964, E Value 0.0, INSD sequence: GenBank: Z82907, with Identities = 534/534 (100%) and UNITE taxon name: Trichocladium citrinoviride. This is a cosmopolitan species known from a wide range of terrestrial habitats and also as an algal endosymbiont (Liang et al. 2016). It is a cellulose decomposer.
description: Published as part of Tibell, Sanja, Tibell, Leif, Pang, Ka-Lai & Jones, E. B. Gareth, 2020, A conspectus of the filamentous marine fungi of Sweden, pp. 141-153 in Botanica Marina (Warsaw, Poland) (Warsaw, Poland) 63 (2) on page 151, DOI: 10.1515/bot-2018-0114, http://zenodo.org/record/11360145
Phytochemical analysis of aerial part of Ikonnikovia kaufmanniana and their protection of DNA damage
Creators: name: Baiseitova, Aizhamal
name: Jenis, Janar
name: Kim, Jeong Yoon
name: Li, Zuo Peng
name: Park, Ki Hun
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Virology

description: Ikonnikovia kaufmanniana is an endemic plant of Kazakhstan of which phytochemical analysis has not been reported. The present study found out that this species enriched with antioxidant chemicals. Isolation and structural identification processes reveal twelve phenolic compounds (1–12) having dihydroflavanonol, flavonol, isoflavone and flavanol skeletons. The annotation of individual components in the extract was carried out by LC-ESI-MS/MS to represent a chemotaxonomic marker of the target plant. The antioxidant activities of all compounds were screened using three different radical sources (DPPH, ORAC, and hydroxyl radicals). Most compounds (1–11) had significant antioxidant activity against three radical sources, and their efficacies were found to differ by their functionality and skeleton. The potential of the isolated compounds in preventing oxidative damage of DNA was evaluated with pBR322 plasmid DNA. Compounds (1, 5, 7, and 8) had protective effects on DNA damaged with 80% efficacy at 60 μM concentration.
Dynamics and asymptotic profiles of endemic equilibrium for two frequency-dependent SIS epidemic models with cross-diffusion
Creators: name: Li, Huicong
name: Peng, Rui
name: Xiang, Tian
Publisher: name: arXiv
Year: 2017
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35K57, 35A01, 35B40, 35Q92, 92D25

description: This paper is concerned with two frequency-dependent SIS epidemic reaction-diffusion models in heterogeneous environment, with a cross-diffusion term modeling the effect that susceptible individuals tend to move away from higher concentration of infected individuals. It is first shown that the corresponding Neumann initial-boundary value problem in an $n$-dimensional bounded smooth domain possesses a unique global classical solution which is uniformly-in-time bounded regardless of the strength of the cross-diffusion and the spatial dimension $n$. It is further shown that, even in the presence of cross-diffusion, the models still admit threshold-type dynamics in terms of the basic reproduction number $\mathcal R_0$; that is, the unique disease free equilibrium is globally stable if $\mathcal R_0<1$, while if $\mathcal R_0>1$, the disease is uniformly persistent and there is an endemic equilibrium, which is globally stable in some special cases with weak chemotactic sensitivity. Our results on the asymptotic profiles of endemic equilibrium illustrate that restricting the motility of susceptible population may eliminate the infectious disease entirely for the first model with constant total population but fails for the second model with varying total population. In particular, this implies that such cross-diffusion does not contribute to the elimination of the infectious disease modelled by the second one.
description: 28 pages, to appear in European Journal of Applied Mathematics
Geodesic Motion of Neutral Particles around a Kerr-Newman Black Hole
Creators: name: Liu, Chen-Yu
name: Lee, Da-Shin
name: Lin, Chi-Yong
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We examine the dynamics of a neutral particle around a Kerr-Newman black hole, and in particular focus on the effects of the charge of the spinning black hole on the motion of the particle. We first consider the innermost stable circular orbits (ISCO) on the equatorial plane. It is found that the presence of the charge of the black hole leads to the effective potential of the particle with stronger repulsive effects as compared with the Kerr black hole. As a result, the radius of ISCO decreases as charge $Q$ of the black hole increases for a fixed value of black hole's angular momentum $a$. We then consider a kick on the particle from its initial orbit out of the equatorial motion. The perturbed motion of the particle will eventually be bounded, or unbounded so that it escapes to spatial infinity. Even more, the particle will likely be captured by the black hole. Thus we analytically and numerically determine the parameter regions of the corresponding motions, in terms of the initial radius of the orbital motion and the strength of the kick. The comparison will be made with the motion of a neutral particle in the Kerr black hole.
description: Published version; 18 pages, 7 figures
FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation
Creators: name: Yang, Xinyi
name: Zhao, Xiaying
name: Zhu, Yuqi
name: Xun, Jingna
name: Wen, Qin
name: Pan, Hanyu
name: Yang, Jinlong
name: Wang, Jing
name: Liang, Zhimin
name: Shen, Xiaoting
name: Liang, Yue
name: Lin, Qinru
name: Liang, Huitong
name: Li, Min
name: Chen, Jun
name: Jiang, Shibo
name: Xu, Jianqing
name: Lu, Hongzhou
name: Zhu, Huanzhang
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Statistics
subject: FOS: Mathematics
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Acquired immunodeficiency syndrome (AIDS) cannot be completely cured, mainly due to the existence of a latent HIV-1 reservoir. However, our current understanding of the molecular mechanisms underlying the establishment and maintenance of HIV-1 latent reservoir is not comprehensive. Here, using a genome-wide CRISPR-Cas9 activation library screening, we identified E3 ubiquitin ligase F-box protein 34 (FBXO34) and the substrate of FBXO34, heterogeneous nuclear ribonucleoprotein U (hnRNP U) was identified by affinity purification mass spectrometry, as new host factors related to HIV-1 latent maintenance. Overexpression of FBXO34 or knockout of hnRNP U can activate latent HIV-1 in multiple latent cell lines. FBXO34 mainly promotes hnRNP U ubiquitination, which leads to hnRNP U degradation and abolishment of the interaction between hnRNP U and HIV-1 mRNA. In a latently infected cell line, hnRNP U interacts with the ReV region of HIV-1 mRNA through amino acids 1-339 to hinder HIV-1 translation, thereby, promoting HIV-1 latency. Importantly, we confirmed the role of the FBXO34/hnRNP U axis in the primary CD4+ T lymphocyte model, and detected differences in hnRNP U expression levels in samples from patients treated with antiretroviral therapy (ART) and healthy people, which further suggests that the FBXO34/hnRNP U axis is a new pathway involved in HIV-1 latency. These results provide mechanistic insights into the critical role of ubiquitination and hnRNP U in HIV-1 latency. This novel FBXO34/hnRNP U axis in HIV transcription may be directly targeted to control HIV reservoirs in patients in the future.
A cancellation mechanism for dark matter-nucleon interaction
Creators: name: Gross, Christian
name: Lebedev, Oleg
name: Toma, Takashi
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We consider a simple Higgs portal dark matter model, where the Standard Model is supplemented with a complex scalar whose imaginary part plays the role of WIMP dark matter (DM). We show that the direct DM detection cross section vanishes at tree level and zero momentum transfer due to a cancellation by virtue of a softly broken symmetry. This cancellation is operative for any mediator masses. As a result, our electroweak scale dark matter satisfies all of the phenomenological constraints quite naturally.
description: v2: 9pages, minor corrections and modifications
Profiling of acetylcholinesterase inhibitory alkaloids from some Crinum, Habranthus and Zephyranthes species by GC–MS combined with multivariate analyses and in silico studies
Creators: name: Shawky, Eman
name: Sohafy, Samah M. El
name: de Andrade, Jean Paulo
name: Borges, Warley de Souza
Publisher: name: Taylor & Francis
Year: 2019
Subjects: Biochemistry
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: Acetylcholinesterase (AChE) inhibitors remain the class of drugs used for the treatment of Alzheimer disease (AD). For the aim of discovering new sources of potent AChE inhibitors, a combined AChE-inhibitory activity together with alkaloid profiles by GC-MS, combined with multivariate statistical analysis for biomarkers determination and in silico studies were attempted. Strategy was applied on leaves, roots and bulbs of six aquatic and terrestrial Amaryllidaceae species. Thirty alkaloids were identified and the AChE inhibitory activities of the extracts were tested by in-vitro Ellman method. Principal bioactive markers were discovered by correlating AChE inhibitory activity with chemical fingerprints via PLS and OPLS modeling which revealed that galanthamine, lycoramine, caranine, tazettine and N-demethylgalanthamine were the most bio-significant markers. Furthermore, the molecular docking was performed to illustrate binding orientations of the top scoring alkaloids in the active site of human acetylcholinesterase. Suggested strategy revealed that, beside galanthamine, caranine, N-demethylgalanthamine, and lycoramine are promising AChE inhibitors.
Primordial-black-hole mergers in dark-matter spikes
Creators: name: Nishikawa, Hiroya
name: Kovetz, Ely D.
name: Kamionkowski, Marc
name: Silk, Joseph
Publisher: name: arXiv
Year: 2017
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: It has been suggested that primordial black holes (PBHs) of roughly 30 solar masses could make up the dark matter and if so, might account for the recent detections by LIGO involving binary black holes in this mass range. It has also been argued that the super-massive black holes (SMBHs) that reside at galactic centers may be surrounded by extremely-dense dark-matter (DM) spikes. Here we show that the rate for PBH mergers in these spikes may well exceed the merger rate considered before in galactic dark-matter halos, depending on the magnitudes of two competing effects on the DM spikes: depletion of PBHs due to relaxation and replenishment due to PBHs in loss cone. This may provide a plausible explanation for the current rate of detection of mergers of 30-solar-mass black holes, even if PBHs make up a subdominant contribution to the dark matter. The gravitational-wave signals from such events will always originate in galactic centers, as opposed to those from halos, which are expected to have little correlation with luminous-galaxy positions.
description: 9 pages, 5 figures; matches publication in PRD
Eucalyptus globulus possesses antihypertensive activity in L-NAME-induced hypertensive rats and relaxes isolated rat thoracic aorta through nitric oxide pathway
Creators: name: Ajebli, Mohammed
name: Eddouks, Mohamed
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: In the current study we determined the effect of the aqueous extract of leaves of Eucalyptus globulus (AEEG) in anesthetized normal and L-NAME-induced hypertensive rats and on rings of isolated thoracic aorta from Wistar rats at a dose of 160 mg/kg. Our results show that AEEG extract reduced systolic, mean and diastolic blood pressure after repeated (7 days) oral administration of this extract in hypertensive rats. In addition, it was revealed from the present study that AEEG relaxed aortic rings in a dose-dependent (25–200 µg/ml) manner via the activation of nitric oxide production. Pre-treatment of aortic rings with indomethacin, glibenclamide, nifedipine or propranolol did not attenuate the AEEG-induced vasorelaxation. Our data elucidate the health-orientated virtues of using AEEG which may play an important role as an antihypertensive agent to reduce the burden of cardiovascular complications.
MOESM3 of Cooperation of hydrolysis modes among xylanases reveals the mechanism of hemicellulose hydrolysis by Penicillium chrysogenum P33
Creators: name: Yang, Yi
name: Yang, Jinshui
name: Wang, Ruonan
name: Liu, Jiawen
name: Zhang, Yu
name: Liu, Liang
name: Wang, Fengqin
name: Yuan, Hongli
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 3: Figure S1. Conversion of glucan and xylan of delignified corn stover by commercial cellulase and the mixture of commercial cellulase and the recombinant xylanases. C: commercial cellulase. The experiments were performed in triplicate, and the data are presented as the means ± standard deviations. Statistical significance is indicated by different letters in columns as assessed by ANOVA (Duncan test, p < 0.05).
Performance Characterization of Multi-threaded Graph Processing Applications on Intel Many-Integrated-Core Architecture
Creators: name: Jiang, Lei
name: Chen, Langshi
name: Qiu, Judy
Publisher: name: arXiv
Year: 2017
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: Intel Xeon Phi many-integrated-core (MIC) architectures usher in a new era of terascale integration. Among emerging killer applications, parallel graph processing has been a critical technique to analyze connected data. In this paper, we empirically evaluate various computing platforms including an Intel Xeon E5 CPU, a Nvidia Geforce GTX1070 GPU and an Xeon Phi 7210 processor codenamed Knights Landing (KNL) in the domain of parallel graph processing. We show that the KNL gains encouraging performance when processing graphs, so that it can become a promising solution to accelerating multi-threaded graph applications. We further characterize the impact of KNL architectural enhancements on the performance of a state-of-the art graph framework.We have four key observations: 1 Different graph applications require distinctive numbers of threads to reach the peak performance. For the same application, various datasets need even different numbers of threads to achieve the best performance. 2 Only a few graph applications benefit from the high bandwidth MCDRAM, while others favor the low latency DDR4 DRAM. 3 Vector processing units executing AVX512 SIMD instructions on KNLs are underutilized when running the state-of-the-art graph framework. 4 The sub-NUMA cache clustering mode offering the lowest local memory access latency hurts the performance of graph benchmarks that are lack of NUMA awareness. At last, We suggest future works including system auto-tuning tools and graph framework optimizations to fully exploit the potential of KNL for parallel graph processing.
description: published as L. Jiang, L. Chen and J. Qiu, "Performance Characterization of Multi-threaded Graph Processing Applications on Many-Integrated-Core Architecture," 2018 IEEE International Symposium on Performance Analysis of Systems and Software (ISPASS), Belfast, United Kingdom, 2018, pp. 199-208
Secundiflorol G isolated from Aeschynomene fascicularis, a Mayan medicinal plant, induces apoptosis in cervical cancer cells
Creators: name: Castillo-Bautista, Cristina M.
name: Torres-Tapia, Luis W.
name: Lagunas-Martínez, Alfredo
name: Contreras-Ochoa, Carla O.
name: Peraza-Sanchez, Sergio R.
name: Moo-Puc, Rosa
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences

description: Secundiflorol G (SG) is an isoflavan isolated from the root bark of Aeschynomene fascicularis, a Mayan medicinal plant used to treat cancer-like symptoms. SG has been shown to have cytotoxic effects on cervical cancer cells (HeLa). Assays were done to identify the mechanisms of SG’s cytotoxic effect. HeLa cells treated with SG exhibited early and late apoptosis, and caspase-9, -8 and -3 activities. It also induces generation of reactive oxygen species and disrupted mitochondrial membrane potential. SG isolated from A. fascicularis induces apoptosis through extrinsic and intrinsic pathways on HeLa cells. SG could be a candidate for in vivo studies and a promising natural compound in cervical cancer treatment.
Non-classification of free Araki-Woods factors and $τ$-invariants
Creators: name: Sasyk, Román
name: Törnquist, Asger
name: Vaes, Stefaan
Publisher: name: arXiv
Year: 2017
Subjects: subject: Operator Algebras (math.OA)
subject: Logic (math.LO)
subject: FOS: Mathematics
subject: 46L36, 46L40, 03E15

description: We define the standard Borel space of free Araki-Woods factors and prove that their isomorphism relation is not classifiable by countable structures. We also prove that equality of $τ$-topologies, arising as invariants of type III factors, as well as coycle and outer conjugacy of actions of abelian groups on free product factors are not classifiable by countable structures.
description: v3: minor changes, final version, to appear in Groups, Geometry, and Dynamics
Diagonal quantum discord
Creators: name: Liu, Zi-Wen
name: Takagi, Ryuji
name: Lloyd, Seth
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum discord measures quantum correlation by comparing the quantum mutual information with the maximal amount of mutual information accessible to a quantum measurement. This paper analyzes the properties of diagonal discord, a simplified version of discord that compares quantum mutual information with the mutual information revealed by a measurement that correspond to the eigenstates of the local density matrices. In contrast to the optimized discord, diagonal discord is easily computable; it also finds connections to thermodynamics and resource theory. Here we further show that, for the generic case of non-degenerate local density matrices, diagonal discord exhibits desirable properties as a preferable discord measure. We employ the theory of resource destroying maps [Liu/Hu/Lloyd, PRL 118, 060502 (2017)] to prove that diagonal discord is monotonically nonincreasing under the operation of local discord nongenerating qudit channels, $d>2$, and provide numerical evidence that such monotonicity holds for qubit channels as well. We also show that it is continuous, and derive a Fannes-like continuity bound. Our results hold for a variety of simple discord measures generalized from diagonal discord.
description: 15 pages, 3 figures; published version
Isomorphism and classification for countable structures
Creators: name: Miller, Russell
Publisher: name: arXiv
Year: 2017
Subjects: subject: Logic (math.LO)
subject: FOS: Mathematics
subject: 03D45 (primary), 03D78 (secondary)

description: We introduce a topology on the space of all isomorphism types represented in a given class of countable models, and use this topology as an aid in classifying the isomorphism types. This mixes ideas from effective descriptive set theory and computable structure theory, extending concepts from the latter beyond computable structures to examine the isomorphism problem on arbitrary countable structures. We give examples using specific classes of fields and of trees, illustrating how the new concepts can yield classifications that reveal differences between seemingly similar classes. Finally, we use a computable homeomorphism to define a measure on the space of isomorphism types of algebraic fields, and examine the prevalence of relative computable categoricity under this measure.
СРАВНИТЕЛЬНАЯ ОЦЕНКА ИНВАЗИВНЫХ И НЕИНВАЗИВНЫХ МЕТОДОВ ЛЕЧЕНИЯ ИШЕМИЧЕСКОЙ БОЛЕЗНИ СЕРДЦА
Creators: name: Олимов, Э.А.
Publisher: name: Zenodo
Year: 2025

description: В работе представлены статистические данные, включая ситуацию в Узбекистане, а также результаты анализа ретроспективных данных 250 пациентов, проходивших лечение различными методами. Целью исследования является сравнение эффективности инвазивных и неинвазивных методов лечения ишемической болезни сердца (ИБС) с позиции клинических результатов, безопасности и прогноза. Результаты показывают, что инвазивные методы демонстрируют лучшие краткосрочные исходы, тогда как неинвазивные методы сохраняют значимость у пациентов с легкой и средней формой заболевания. Наилучшие результаты достигаются при комбинированном подходе.
First identification of human infection with Erysipelothrix Piscisicarius by metagenomic next-generation sequencing
Creators: name: Huang, Weifeng
name: Han, Dan
name: Cai, Qingqing
name: Yi, Xiaoli
name: Tang, Jin
name: Fang, Yuan
name: Lu, Yihan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: First identification of human infection with Erysipelothrix Piscisicarius by metagenomic next-generation sequencing
Ultra-luminous X-ray sources as super-critical propellers
Creators: name: Erkut, M. Hakan
name: Ekşi, Kazım Yavuz
name: Alpar, M. Ali
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We study the evolution of newborn neutron stars in high-mass X-ray binaries interacting with a wind-fed super-Eddington disk. The inner disk is regularized to a radiation-dominated quasi-spherical configuration for which we calculate the inner radius of the disk, the total luminosity of the system and the torque acting on the neutron star accordingly, following the evolution of the system through the ejector and early propeller stages. We find that the systems with $B \gtrsim 10^{13}$ G pass through a short ($\sim 20\,{\rm yr}$) ejector stage appearing as supernova impostors followed by a propeller stage lasting $\sim 10^3\,{\rm yr}$. In the super-critical propeller stage the system is still bright ($L\sim 10^{40}\,{\rm erg\, s^{-1}}$) due to the spindown power and therefore appears as an ultra-luminous X-ray source (ULX). The system evolves into pulsating ULX (PULX) when the neutron star spins down to a period ($P\sim 1$ s) allowing for accretion onto its surface to commence. Systems with lower magnetic fields, $B \sim 10^{11}$ G, pass through a long ($10^5\,{\rm yr}$) super-critical propeller stage with luminosities similar to those of the ultra-luminous super-soft sources (ULS), $L \lesssim 10^{40}\,{\rm erg\, s^{-1}}$. The equilibrium periods of these systems in the accretion stage is about $10\,{\rm ms}$, which is much smaller than the typical period range of PULX observed to date. Such systems could have a larger population, but their pulsations would be elusive due to the smaller size of the magnetosphere. Our results suggest that the ULS and some nonpulsating ULX are rapidly spinning and highly magnetized young neutron stars at the super-critical propeller stage.
description: ApJ in press. 9 pages, 4 figures
Antimicrobial substances from Amazonian Aniba (Lauraceae) species
Creators: name: da Silva, Yasmin Cunha
name: Silva, Emily Marcele Soares
name: de Souza Fernandes, Nilma
name: Lopes, Nathália Lamenha
name: Orlandi, Patrícia Puccinelli
name: Nakamura, Celso Vataru
name: Costa, Emmanoel Vilaça
name: da Veiga Júnior, Valdir Florêncio
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Computational Biology

description: Extracts and six isolated substances from Aniba (Lauraceae) Amazonian species A. parviflora, A. panurensis and A. rosaeodora were analysed in vitro to their antibacterial, antiparasitic and antiplasmodial activities. NMR and MS experiments led to the identification of three styrylpyrones (5,6-dihydrokawain [I], 4-methoxy-11,12-methylenedioxy-6-trans-styryl-pyran-2-one [II] and rel-(6R,7S,8S,5′S)-4′-methoxy-8-(11,12-dimethoxyphenyl-7-[6-(4-methoxy-2-pyranyl)]-6-(E)-styryl-1′-oxabicyclo[4,2,0]oct-4′-en-2′-one [III]), a pyridine alkaloid (anibine [IV]) and two kavalactones (tetrahydroyangonin [V] and dihydromethysticin [VI]). The best antibacterial result was observed at the hexane fraction of A. panurensis (MIC 7.8 μg/mL against the three bacteria). Equal MIC were observed by the extract and dichloromethane fraction of A. panurensis against S. simulans and S. aureus; and 15.62 μg/mL against MRSA. Similarly, only A. panurensis extracts showed in vitro activities against Tripanossoma cruzi and Leishmania amazonensis parasites. In Plasmodium falciparum assay, 5,6-dihydrokawain was considered an active antimalarial (14.03 μM), and substances II (132.94 μM) and III (41.84 μM) presented moderate activities.
A compact cosmic muon veto detector and possible use with the Iron Calorimeter detector for neutrinos
Creators: name: Panchal, Neha
name: Mohanraj, S.
name: Kumar, A.
name: Dey, T.
name: Majumder, G.
name: Shinde, R.
name: Verma, P.
name: Satyanarayana, B.
name: Datar, V. M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The motivation for a cosmic muon veto (CMV) detector is to explore the possibility of locating the proposed large Iron Calorimeter (ICAL) detector at the India based Neutrino Observatory (INO) at a shallow depth. An initial effort in that direction, through the assembly and testing of a $\sim$ 1 m $\times$ 1 m $\times$ 0.3 m plastic scintillator based detector, is described. The plan for making a CMV detector for a smaller prototype mini-ICAL is also outlined.
MOESM4 of Cooperation of hydrolysis modes among xylanases reveals the mechanism of hemicellulose hydrolysis by Penicillium chrysogenum P33
Creators: name: Yang, Yi
name: Yang, Jinshui
name: Wang, Ruonan
name: Liu, Jiawen
name: Zhang, Yu
name: Liu, Liang
name: Wang, Fengqin
name: Yuan, Hongli
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Additional file 4: Table S3. The amount of products (mg/mL) released by Xyl1 and Xyl3 from xylooligosaccharides.