Answer by taking a quote from the following article:

Francisco Pizarro was born in Trujillo, Caceres, Spain (then in the Crown of Castile) in modern-day Extremadura, Spain. He was the illegitimate son of infantry colonel Gonzalo Pizarro (1446-1522) and Francisca Gonzalez, a woman of poor means. His date of birth is uncertain, but it is believed to be sometime in the 1470s, probably 1474. Little attention was paid to his education and he grew up illiterate.

On 10 November 1509, Pizarro sailed from Spain to the New World with Alonso de Ojeda on an expedition to Uraba. He sailed to Cartagena and joined the fleet of Martin Fernandez de Enciso and, in 1513, accompanied Balboa to the Pacific. In 1514, he found a supporter in Pedro Arias Davila, the Governor of Castilla de Oro and was rewarded for his role in the arrest of Balboa with the positions of mayor and magistrate in Panama City, serving from 1519 to 1523. Reports of Peru's riches and Cortes's success in Mexico tantalized Pizarro. He undertook two expeditions to conquer the Incan Empire in 1524 and in 1526. Both failed as a result of native hostilities, bad weather and lack of provisions. Pedro de los Rios, the Governor of Panama, made an effort to recall Pizarro, but the conquistador resisted and remained in the south. In April 1528, he reached northern Peru and found the natives rich with precious metals. This discovery gave Pizarro the motivation to plan a third expedition to conquer the area. He returned to Panama to make arrangements, but the Governor refused to grant permission for the project. Pizarro returned to Spain to appeal directly to King Charles I. His plea was successful and he received not only a license for the proposed expedition, but also authority over any lands conquered during the venture. He was joined by family and friends and the expedition left Panama in 1530. When hostile natives along the coast threatened the expedition, Pizarro moved inland and founded the first Spanish settlement in Peru, San Miguel de Piura. Atahualpa refused to tolerate a Spanish presence in his lands, but was captured by Pizarro during the Battle of Cajamarca on 16 November 1532. A ransom for the emperor's release was demanded and Atahualpa filled a room with gold, but Pizarro charged him with various crimes and executed him on 26 July 1533, overriding his associates who thought he was overstepping his authority. The same year, Pizarro entered the Inca capital of Cuzco and completed his conquest of Peru. In January 1535, Pizarro founded the city of Lima, a project he considered his greatest achievement. Quarrels between Pizarro and his longtime comrade-in-arms Diego Almagro culminated in the Battle of Las Salinas. Almagro was captured and executed and, on 26 June 1541, his embittered son, Diego de Almagro "el mozo", assassinated Pizarro in Lima. The conquistador of Peru was laid to rest in the Lima Cathedral. Two years later Pizarro, Almagro and Luque started the arrangements for a second expedition with permission from Pedrarias Davila. The governor, who himself was preparing an expedition north to Nicaragua, was reluctant to permit another expedition, having lost confidence in Pizarro. The three associates eventually won his trust and he acquiesced. By this time, a new governor was to arrive and succeed Davila. Pedro de los Rios took charge in July 1526 and initially approved Pizarro's expeditions (he would join him several years later in Peru). On 10 March 1526 Pizarro left Panama with two ships with 160 men and several horses, reaching as far as the Colombian San Juan River. Soon after arriving the party separated, with Pizarro staying to explore the new and often perilous territory off the swampy Colombian coasts, while the expedition's co-commander, Almagro, returned to Panama for reinforcements. Pizarro's Piloto Mayor (main pilot), Bartolome Ruiz, continued sailing south and, after crossing the equator, found and captured a balsa (raft) under sail, with natives from Tumbes. To everyone's surprise, these carried textiles, ceramic objects and some pieces of gold, silver and emeralds, making Ruiz's findings the central focus of this second expedition. Some natives were taken aboard Ruiz's ship to serve as interpreters. He then set sail north for the San Juan River, arriving to find Pizarro and his men exhausted from the difficulties they had faced exploring the new territory. Soon Almagro sailed into the port laden with supplies and a reinforcement of at least eighty recruits who had arrived at Panama from Spain with an expeditionary spirit. The findings and excellent news from Ruiz along with Almagro's new reinforcements cheered Pizarro and his tired followers. They decided to sail back to the territory already explored by Ruiz and, after a difficult voyage due to strong winds and currents, reached Atacames on the Ecuadorian coast. Here, they found a large native population recently brought under Inca rule. Unfortunately for the conquistadores, the warlike spirit of the people they encountered seemed so defiant and dangerous in numbers that the Spanish decided not to enter the land. When the new governor of Panama, Pedro de los Rios, refused to allow for a third expedition to the south, the associates resolved for Pizarro to leave for Spain and appeal to the sovereign in person. Pizarro sailed from Panama for Spain in the spring of 1528, accompanied by Pedro de Candia, some natives and llamas, plus samples of fabric, gold and silver. Pizzaro reached Seville in early summer. King Charles I, who was at Toledo, had an interview with Pizarro and heard of his expeditions in South America. The conquistador described the territory as rich in gold and silver that he and his followers had bravely explored "to extend the empire of Castile". The king, who was soon to leave for Italy, was impressed at his accounts and promised his support for the conquest of Peru. Queen Isabel, though, in the absence of the king, signed the Capitulacion de Toledo on 6 July 1529, a license document that authorized Pizarro to proceed with the conquest of Peru. Pizarro was officially named the Governor, Captain general, Adelantado and Alguacil Mayor, of New Castile for the distance of 200 leagues along the newly discovered coast and invested with all authority and prerogatives, leaving his associates in secondary positions (a fact that later incensed Almagro and would lead to eventual discord). One of the grant conditions was that within six months, Pizarro should raise a sufficiently equipped force of 250 men, of whom 100 might be drawn from the colonies. This gave Pizarro time to leave for his native Trujillo and convince his brother Hernando Pizarro and other close friends to join him on his third expedition. Francisco de Orellana joined the group and would later discover and explore the length of the Amazon River. Two more of his brothers from his father, Juan Pizarro and Gonzalo Pizarro, and a brother from his mother, Francisco Martin de Alcantara, later decided to join him, as well as his cousin Pedro Pizarro, who served as his page. When the expedition left the following year, it numbered three ships, 180 men and 27 horses. Pizarro could not raise the number of men the Capitulacion required and sailed clandestinely from the port of Sanlucar de Barrameda for the Canary Island of La Gomera in January 1530. He was there joined by his brother Hernando and the remaining men in two vessels that would sail back to Panama. Pizarro's third and final expedition left Panama for Peru on 27 December 1530. CANNOTANSWER

Did anyone try to overthrow him?

the warlike spirit of the people they encountered seemed so defiant and dangerous in numbers that the Spanish decided not to enter